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Sample records for adder vipera berus

  1. The adder (Vipera berus) in Southern Altay Mountains: population characteristics, distribution, morphology and phylogenetic position.

    PubMed

    Cui, Shaopeng; Luo, Xiao; Chen, Daiqiang; Sun, Jizhou; Chu, Hongjun; Li, Chunwang; Jiang, Zhigang

    2016-01-01

    As the most widely distributed snake in Eurasia, the adder (Vipera berus) has been extensively investigated in Europe but poorly understood in Asia. The Southern Altay Mountains represent the adder's southern distribution limit in Central Asia, whereas its population status has never been assessed. We conducted, for the first time, field surveys for the adder at two areas of Southern Altay Mountains using a combination of line transects and random searches. We also described the morphological characteristics of the collected specimens and conducted analyses of external morphology and molecular phylogeny. The results showed that the adder distributed in both survey sites and we recorded a total of 34 sightings. In Kanas river valley, the estimated encounter rate over a total of 137 km transects was 0.15 ± 0.05 sightings/km. The occurrence of melanism was only 17%. The small size was typical for the adders in Southern Altay Mountains in contrast to other geographic populations of the nominate subspecies. A phylogenetic tree obtained by Bayesian Inference based on DNA sequences of the mitochondrial cytochrome b (1,023 bp) grouped them within the Northern clade of the species but failed to separate them from the subspecies V. b. sachalinensis. Our discovery extends the distribution range of V. berus and provides a basis for further researches. We discuss the hypothesis that the adder expands its distribution border to the southwest along the mountains' elevation gradient, but the population abundance declines gradually due to a drying climate. PMID:27602300

  2. The adder (Vipera berus) in Southern Altay Mountains: population characteristics, distribution, morphology and phylogenetic position

    PubMed Central

    Cui, Shaopeng; Luo, Xiao; Chen, Daiqiang; Sun, Jizhou; Chu, Hongjun

    2016-01-01

    As the most widely distributed snake in Eurasia, the adder (Vipera berus) has been extensively investigated in Europe but poorly understood in Asia. The Southern Altay Mountains represent the adder’s southern distribution limit in Central Asia, whereas its population status has never been assessed. We conducted, for the first time, field surveys for the adder at two areas of Southern Altay Mountains using a combination of line transects and random searches. We also described the morphological characteristics of the collected specimens and conducted analyses of external morphology and molecular phylogeny. The results showed that the adder distributed in both survey sites and we recorded a total of 34 sightings. In Kanas river valley, the estimated encounter rate over a total of 137 km transects was 0.15 ± 0.05 sightings/km. The occurrence of melanism was only 17%. The small size was typical for the adders in Southern Altay Mountains in contrast to other geographic populations of the nominate subspecies. A phylogenetic tree obtained by Bayesian Inference based on DNA sequences of the mitochondrial cytochrome b (1,023 bp) grouped them within the Northern clade of the species but failed to separate them from the subspecies V. b. sachalinensis. Our discovery extends the distribution range of V. berus and provides a basis for further researches. We discuss the hypothesis that the adder expands its distribution border to the southwest along the mountains’ elevation gradient, but the population abundance declines gradually due to a drying climate. PMID:27602300

  3. Paternity determination in the adder (Vipera berus)--DNA fingerprinting or random amplified polymorphic DNA?

    PubMed

    Tegelström, H; Höggren, M

    1994-08-01

    We performed breeding experiments with adders (Vipera berus) to determine whether multiple matings may result in multiple paternity. DNA fingerprinting of mothers, their offspring, and possible fathers using a polydinucleotide probe [(TG)n] gave a low overall similarity between unrelated individuals (0.18 +/- 0.07; SD) and an average of 17 bands that were male-specific. In no cases were there fewer than seven paternal-specific bands present in the fingerprint of an offspring, enabling us unambiguously to identify the biological father among five males. Multiple paternity was detected in the investigated broods with offspring sired exclusively by the captive males. PCR amplification of random amplified polymorphic DNA (RAPD) using 16 decamer primers gave 76 bands and an average similarity of 0.95 (+/- 0.01) between the males, which were collected at different, geographically well-separated localities. Although there were on average 8.3 (+/- 1.9) bands that differ between males in pairwise comparisons, there were only 1.9 (+/- 1.1) bands per male that are specific for a particular individual. Thus, RAPDs are adequate for paternity determination only in experiments with a low number of males, whereas DNA fingerprinting offers sufficient information to discriminate between large numbers of putative fathers. PMID:7826312

  4. Clinical and biochemical changes in 53 Swedish dogs bitten by the European adder - Vipera berus

    PubMed Central

    2010-01-01

    Background Every year many dogs in Sweden are bitten by Vipera berus, the only venomous viper in Sweden. This prospective study investigated clinical signs, some biochemical parameters, treatment, and progress of disease after snakebite in 53 dogs. Effects of treatment with and without glucocorticoids were evaluated. Methods All fifty-three dogs bitten by Vipera berus were examined the same day the dog was bitten and the next day. Two more examinations during 23 days post snake bite were included. Creatinine, creatine kinase (CK), alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH), alkaline phosphatase (ALP) and bile acid results were followed through 3 to 4 samplings from 34 of the dogs. Results All dogs had variable severity of local swelling in the bite area and 73 per cent had affected mental status. Initial cardiac auscultation examination was normal in all dogs, but six dogs had cardiac abnormalities at their second examination, including cardiac arrhythmias and cardiac murmurs. All dogs received fluid therapy, 36 dogs were given analgesics, 22 dogs were treated with glucocorticoids, and ten dogs were treated with antibiotics. Evidence of transient muscle damage (increased CK) was seen one day after the snake bite in 15 (54%) of 28 sampled dogs. Moderate changes in hepatic test results occurred in 1 dog and several dogs (22 of 34) had transient, minor increases in one or more hepatic test result. No dog died during the observation period as a consequence of the snake bite. Conclusions Snake bite caused local swelling in all dogs and mental depression of short duration in most dogs. Some dogs had transient clinical signs that could be indicative of cardiac injury and some other had transient biochemical signs of liver injury. Treatment with glucocorticoids did not have any clear positive or negative effect on clinical signs and mortality. PMID:20416040

  5. Cloacal aerobic bacterial flora and absence of viruses in free-living slow worms (Anguis fragilis), grass snakes (Natrix natrix) and European Adders (Vipera berus) from Germany.

    PubMed

    Schmidt, Volker; Mock, Ronja; Burgkhardt, Eileen; Junghanns, Anja; Ortlieb, Falk; Szabo, Istvan; Marschang, Rachel; Blindow, Irmgard; Krautwald-Junghanns, Maria-Elisabeth

    2014-12-01

    Disease problems caused by viral or bacterial pathogens are common in reptiles kept in captivity. There is no information available on the incidence of viral pathogens or the physiological cloacal bacterial flora of common free-living reptiles in Germany. Therefore, 56 free-living reptiles including 23 European adders (Vipera berus), 12 grass snakes (Natrix natrix) and 21 slow worms (Anguis fragilis) were investigated on the island Hiddensee in northeastern Germany. Pharyngeal and cloacal swabs were taken immediately after capture. Bacteriological examination was performed from the cloacal swabs to study the aerobic cloacal flora. Molecular biological examination included amplification of DNA or RNA from adeno-, rana- and ferlaviruses as well as culturing on Russell's viper heart cells for virus isolation. Salmonella spp. were isolated from European adders but not from the other reptiles examined. The minimal inhibitory concentration was determined from the isolated Salmonella spp. However, some potentially human pathogenic bacteria, such as Proteus vulgaris, Aeromonas hydrophila, Klebsiella pneumoniae and Escherichia coli were isolated. Viruses were not detected in any of the examined reptiles. To the authors' best knowledge, the present study is the first survey of viral pathogens in free-living snakes and slow worms in Germany and the first survey of cloacal aerobic bacterial flora of slow worms. PMID:24866333

  6. [Envenoming by common viper (Vipera berus)--subject still exists...].

    PubMed

    Ciszowski, Krzysztof; Modła, Arkadiusz

    2004-01-01

    The only venomous reptile that naturally occurs in Poland is the adder or common viper (Vipera berus). Its bites are not of great epidemiological importance, but in some cases serious life-threatening symptoms may appear. The most common symptoms of adder envenomation are: local edema, reddening and pain of the bitten site and also the general symptoms coming from the alimentary tract (vomiting, diarrhoea, abdominal pain), the circulatory system (hypotension, shock, ECG abnormalities), the central nervous system (sleepiness, vertigo, disorientation, loss of consciousness), hematological symptoms (leukocytosis, hemolysis, coagulopathy) and allergic symptoms (fever, urticaria, angio-oedema). In the present study we described the case of a twenty-year-old patient hospitalized at the Toxicology Department of the Collegium Medicum UJ after a viper bite. Except for some above-mentioned symptoms he also developed ocular symptoms like ptosis and blurred vision. Such symptoms after the common viper bite have not been described in the literature till now. The cause of them seems to be an intense allergic reaction in the region of the orbit and eyelids all the more so because the patient had the positive allergy history. However, taking into account the latest reports from the literature, a neurotoxic action of some components of the Vipera berus venom may also play a role. Because of the developing general symptoms a specific equine antivenom was administered to the patient, apart from the supportive care, without any serious side effects that usually are observed after the use of such a kind of sera. It is thought that the sheep antivenom is better than the equine one considering a lack of allergic side effects. As a result of applied treatment the local and general symptoms including ocular symptoms subsided. PMID:15521621

  7. Immunological Cross-Reactivity and Neutralisation of European Viper Venoms with the Monospecific Vipera berus Antivenom ViperaTAb

    PubMed Central

    Casewell, Nicholas R.; Al-Abdulla, Ibrahim; Smith, David; Coxon, Ruth; Landon, John

    2014-01-01

    Medically important cases of snakebite in Europe are predominately caused by European vipers of the genus Vipera. The mainstay of snakebite therapy is polyclonal antibody therapy, referred to as antivenom. Here we investigate the capability of the monospecific V. berus antivenom, ViperaTAb®, to cross-react with, and neutralise lethality induced by, a variety of European vipers. Using ELISA and immunoblotting, we find that ViperaTAb® antibodies recognise and bind to the majority of toxic components found in the venoms of the Vipera species tested at comparably high levels to those observed with V. berus. Using in vivo pre-clinical efficacy studies, we demonstrate that ViperaTAb® effectively neutralises lethality induced by V. berus, V. aspis, V. ammodytes and V. latastei venoms and at much higher levels than those outlined by regulatory pharmacopoeial guidelines. Notably, venom neutralisation was found to be superior to (V. berus, V. aspis and V. latastei), or as equally effective as (V. ammodytes), the monospecific V. ammodytes “Zagreb antivenom”, which has long been successfully used for treating European snake envenomings. This study suggests that ViperaTAb® may be a valuable therapeutic product for treating snakebite by a variety of European vipers found throughout the continent. PMID:25153254

  8. Snake (Vipera berus) bite: The cause of severe anaphylactic shock and hepatocellular injury.

    PubMed

    Pałgan, K; Kuźmiński, A; Janik, A; Gotz-Żbikowska, M; Bartuzi, Z

    2015-03-01

    Vipera berus bites lead to a variety of clinical manifestations. Local swelling, coagulopathy, nephrotoxicity, cardiac effects and myotoxicity are known to be associated with envenoming by a viper bite. Although a variety of clinical manifestations have been reported in viper bite cases, anaphylactic reactions and liver injury events have not been described. We report a unique case of an anaphylaxis and transitional liver cell injury due to a Vipera berus bite in the case of a 58-year-old man with no past history suggestive of allergy and liver disease. These observations need to be further explored with laboratory studies to identify the venom components which could have pre-disposed the patient to the development of these complications. PMID:25816414

  9. Hemorrhagic stomatitis in a natural hybrid of Vipera ammodytes × Vipera berus due to inappropriate substrate in terrarium

    PubMed Central

    CZIRJÁK, Gábor Árpád; KÖBÖLKUTI, Lóránd Béla; TENK, Miklós; SZAKÁCS, Attila; KELEMEN, Attila; SPÎNU, Marina

    2015-01-01

    A natural hybrid of Vipera ammodytes × Vipera berus was presented having low body weight, seizures and generalized swelling of the cephalic region. Based on the history of the case and clinical examination, hemorrhagic stomatitis of traumatic origin was diagnosed. The snake was kept in a terrarium with wood chips as a substrate, and the material had induced trauma in the oral mucosa which was further complicated with Salmonella Arizonae and Morganella morganii co-infection, abscessation and osteomyelitis. To the best of the authors’ knowledge, this is the first reported case of bacterial infection in European snake hybrids and one of a few case reports in European snakes. Although wood chips are an inexpensive substrate, based on our findings, they should be avoided when keeping and breeding European vipers. PMID:25715871

  10. Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells

    PubMed Central

    Samel, Mari; Vija, Heiki; Kurvet, Imbi; Künnis-Beres, Kai; Trummal, Katrin; Subbi, Juhan; Kahru, Anne; Siigur, Jüri

    2013-01-01

    Secretory phospholipasesA2 (sPLA2s) form a large family of structurally related enzymes widespread in nature. Herein, we studied the inhibitory effects of sPLA2s from Vipera lebetina (VLPLA2), Vipera berus berus (VBBPLA2), and Naja naja oxiana (NNOPLA2) venoms on (i) human platelets, (ii) four different bacterial strains (gram-negative Escherichia coli and Vibrio fischeri; gram-positive Staphylococcus aureus and Bacillus subtilis) and (iii) five types of cancer cells (PC-3, LNCaP, MCF-7, K-562 and B16-F10) in vitro. sPLA2s inhibited collagen-induced platelet aggregation: VBBPLA2 IC50 = 0.054, VLPLA2 IC50 = 0.072, NNOPLA2 IC50 = 0.814 μM. p-Bromophenacylbromide-inhibited sPLA2 had no inhibitory action on platelets. 36.17 μM VBBPLA2 completely inhibited the growth of gram-positive Bacillus subtilis whereas no growth inhibition was observed towards gram-negative Escherichia coli. The inhibitory action of sPLA2s (~0.7 μM and ~7 μM) towards cancer cells depended on both venom and cell type. VBBPLA2 (7.2 μM) inhibited significantly the viability of K-562 cells and the cell death appeared apoptotic. The sPLA2s exhibited no inhibitory effect towards LNCaP cells and some effect (8%–20%) towards other cells. Thus, already sub-μM concentrations of sPLA2s inhibited collagen-induced platelet aggregation and from the current suite of studied svPLA2s and test cells, VBBPLA2 was the most growth inhibitory towards Bacillus subtilis and K-562 cells. PMID:23348053

  11. Lethal case of Vipera bersus bite.

    PubMed

    Tranca, Sebastian; Cocis, Mihaela; Antal, Oana

    2016-01-01

    Adder bites are rare events, but they can be fatal. Three adder types live in Romania - Vipera ammodytes, Vipera ursini and Vipera berus. Most adder bites happen during the summer with a peak incidence between July and August. Here we present the case of a 56 years old male patient who was bitten by an adder. The clinical presentation was severe from the beginning with a GCS of 3 points, respiratory and cardiovascular failure; despite of adequate treatment the patient developed multiorgan dysfunction and died 36 hours after the ICU admission. The aim of this report is to raise awareness that snake bites can have a life-threatening course and need immediate attention and medical care. PMID:27547066

  12. Lethal case of Vipera bersus bite

    PubMed Central

    TRANCA, SEBASTIAN; COCIS, MIHAELA; ANTAL, OANA

    2016-01-01

    Adder bites are rare events, but they can be fatal. Three adder types live in Romania - Vipera ammodytes, Vipera ursini and Vipera berus. Most adder bites happen during the summer with a peak incidence between July and August. Here we present the case of a 56 years old male patient who was bitten by an adder. The clinical presentation was severe from the beginning with a GCS of 3 points, respiratory and cardiovascular failure; despite of adequate treatment the patient developed multiorgan dysfunction and died 36 hours after the ICU admission. The aim of this report is to raise awareness that snake bites can have a life-threatening course and need immediate attention and medical care. PMID:27547066

  13. ADDER CIRCUIT

    DOEpatents

    Jacobsohn, D.H.; Merrill, L.C.

    1959-01-20

    An improved parallel addition unit is described which is especially adapted for use in electronic digital computers and characterized by propagation of the carry signal through each of a plurality of denominationally ordered stages within a minimum time interval. In its broadest aspects, the invention incorporates a fast multistage parallel digital adder including a plurality of adder circuits, carry-propagation circuit means in all but the most significant digit stage, means for conditioning each carry-propagation circuit during the time period in which information is placed into the adder circuits, and means coupling carry-generation portions of thc adder circuit to the carry propagating means.

  14. A Single Dose of Viperfav(TM) May Be Inadequate for Vipera ammodytes Snake Bite: A Case Report and Pharmacokinetic Evaluation.

    PubMed

    Kurtović, Tihana; Brvar, Miran; Grenc, Damjan; Lang Balija, Maja; Križaj, Igor; Halassy, Beata

    2016-01-01

    Viperfav(TM) is a commercial F(ab')₂ antivenom prepared against European vipers venom. It is safe and effective for treating envenomation caused by Vipera aspis and Vipera berus. Therapeutic efficacy for treating Vipera ammodytes ammodytes (V. a. ammodytes) envenoming has not been yet described, although protective efficacy has been demonstrated in preclinical studies. We report on a 32-year-old man bitten by V. a. ammodytes who was treated with Viperfav™. Viperfav™ promptly reduced local extension and improved systemic pathological signs, but 24 h after the incident a recurrence of thrombocytopenia occurred despite a favorable pharmacokinetic profile with systemic clearance (1.64 (mL·h(-1))·kg(-1)) and elimination half-life (97 h) among the highest ever reported. The recommended dose of Viperfav™ for V. aspis and V. berus bites may be inadequate for serious V. a. ammodytes envenomations. Following V. a. ammodytes bite, serial blood counts and coagulation profiles should be performed to help guide Viperfav™ treatment, along with supplemental administration as indicated. PMID:27548220

  15. A Single Dose of ViperfavTM May Be Inadequate for Vipera ammodytes Snake Bite: A Case Report and Pharmacokinetic Evaluation

    PubMed Central

    Kurtović, Tihana; Brvar, Miran; Grenc, Damjan; Lang Balija, Maja; Križaj, Igor; Halassy, Beata

    2016-01-01

    ViperfavTM is a commercial F(ab’)2 antivenom prepared against European vipers venom. It is safe and effective for treating envenomation caused by Vipera aspis and Vipera berus. Therapeutic efficacy for treating Vipera ammodytes ammodytes (V. a. ammodytes) envenoming has not been yet described, although protective efficacy has been demonstrated in preclinical studies. We report on a 32-year-old man bitten by V. a. ammodytes who was treated with Viperfav™. Viperfav™ promptly reduced local extension and improved systemic pathological signs, but 24 h after the incident a recurrence of thrombocytopenia occurred despite a favorable pharmacokinetic profile with systemic clearance (1.64 (mL·h−1)·kg−1) and elimination half-life (97 h) among the highest ever reported. The recommended dose of Viperfav™ for V. aspis and V. berus bites may be inadequate for serious V. a. ammodytes envenomations. Following V. a. ammodytes bite, serial blood counts and coagulation profiles should be performed to help guide Viperfav™ treatment, along with supplemental administration as indicated. PMID:27548220

  16. Vipera lebetina venom nucleases.

    PubMed

    Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Siigur, Jüri; Siigur, Ene

    2016-09-01

    Nucleases, in particular ribo- and deoxyribonucleases, are among the least-studied snake venom enzymes. In the present study we have partially purified different nucleases from Vipera lebetina venom. The DNase activity has been proved by DNA degradation both in solution as well as in-gel (zymogram-method). In DNA-containing SDS-PAGE V. lebetina venom exhibits DNA-degrading activity in bands with molecular masses of ∼120, 30-35 and 22-25 kDa. The 120 kDa band corresponds to phosphodiesterase, a 3', 5'-exonuclease. The endonucleolytic activity of the lower-molecular-mass protein has been confirmed by plasmid degradation and the visualization of the results in agarose gel (with ethidium bromide) electrophoresis. A partial DNA sequence of putative RNase H1 has been determined from the V. lebetina venom gland cDNA library. The translated sequence is similar to the assumed RNase H1 from Crotalus adamanteus (AFJ51163). The RNA/DNA hybrid is hydrolysed by V. lebetina venom and venom fractions. The masses of tryptic peptides from the SDS-PAGE 30-35 kDa band are in concordance with the theoretical peptide masses from the respective translated sequence. For the first time RNase H1-like enzyme activity has been ascertained in snake venom, and sequencing a relevant partial transcript confirmed the identification of this enzyme. PMID:27179419

  17. On fast carry select adders

    NASA Technical Reports Server (NTRS)

    Shamanna, M.; Whitaker, S.

    1992-01-01

    This paper presents an architecture for a high-speed carry select adder with very long bit lengths utilizing a conflict-free bypass scheme. The proposed scheme has almost half the number of transistors and is faster than a conventional carry select adder. A comparative study is also made between the proposed adder and a Manchester carry chain adder which shows that the proposed scheme has the same transistor count, without suffering any performance degradation, compared to the Manchester carry chain adder.

  18. Inductive Adder development

    SciTech Connect

    Miller, R.B.; Davis, B.B.; Bayless, J.

    1989-05-01

    TITAN has successfully developed an Inductive Adder for use with a Hewlett-Packard Model 43734A Marx pulser. The unit provides an 800 kV peak output pulse to a modified HP 5081-9551 1 MV x-ray tube. The tube fits into the adder unit, and can thus be remotely operated. It delivers a peak on-axis dose of 35 mR at a one meter distance. Supporting radiography analyses, a description of the inductive adder approach and construction, and detailed test data are presented.

  19. The Forbidden Quantum Adder

    NASA Astrophysics Data System (ADS)

    Alvarez-Rodriguez, U.; Sanz, M.; Lamata, L.; Solano, E.

    2015-07-01

    Quantum information provides fundamentally different computational resources than classical information. We prove that there is no unitary protocol able to add unknown quantum states belonging to different Hilbert spaces. This is an inherent restriction of quantum physics that is related to the impossibility of copying an arbitrary quantum state, i.e., the no-cloning theorem. Moreover, we demonstrate that a quantum adder, in absence of an ancillary system, is also forbidden for a known orthonormal basis. This allows us to propose an approximate quantum adder that could be implemented in the lab. Finally, we discuss the distinct character of the forbidden quantum adder for quantum states and the allowed quantum adder for density matrices.

  20. The Forbidden Quantum Adder.

    PubMed

    Alvarez-Rodriguez, U; Sanz, M; Lamata, L; Solano, E

    2015-01-01

    Quantum information provides fundamentally different computational resources than classical information. We prove that there is no unitary protocol able to add unknown quantum states belonging to different Hilbert spaces. This is an inherent restriction of quantum physics that is related to the impossibility of copying an arbitrary quantum state, i.e., the no-cloning theorem. Moreover, we demonstrate that a quantum adder, in absence of an ancillary system, is also forbidden for a known orthonormal basis. This allows us to propose an approximate quantum adder that could be implemented in the lab. Finally, we discuss the distinct character of the forbidden quantum adder for quantum states and the allowed quantum adder for density matrices. PMID:26153134

  1. A mitochondrial DNA phylogeny of the endangered vipers of the Vipera ursinii complex.

    PubMed

    Gvoždík, Václav; Jandzik, David; Cordos, Bogdan; Rehák, Ivan; Kotlík, Petr

    2012-03-01

    The last two populations of the Hungarian meadow viper Vipera ursinii rakosiensis were thought to persist in the steppe fragments of Hungary until meadow vipers were discovered in central Romania (Transylvania), suggesting a possible existence of remnant populations elsewhere. We assessed the phylogenetic position of the Transylvanian vipers using 2030 bp of mitochondrial DNA sequence. We showed that they were closely related to the Hungarian vipers, while those from northeastern Romania (Moldavia) and Danube Delta belonged to the subspecies Vipera ursinii moldavica. Montane subspecies from Europe (Vipera ursinii ursinii and Vipera ursinii macrops) formed a sister clade to the two lowland subspecies. Vipera renardi formed a sister clade to V. ursinii, with populations from the Greater Caucasus (Vipera renardi lotievi) and Tien Shan (Vipera renardi tienshanica) as the sister group to Vipera renardi renardi, and Vipera renardi eriwanensis from the Lesser Caucasus as the most basal taxon in the species. Our results illustrate that the divergence between the lowland and montane populations occurred separately in each species and several times in V. renardi. We demonstrated that the recently discovered Transylvanian population is the third surviving population of V. u. rakosiensis and the only known population outside of Hungary. PMID:22182992

  2. [Snake bite in a 53-year-old female tourist].

    PubMed

    Bertheau, S; Aghdassi, A; Otto, M; Hegenscheid, K; Runge, S; Lerch, M M; Simon, P

    2015-02-01

    Snake bites are rare events in Germany and are not life-threatening with usually only mild clinical symptoms. The most widespread venomous snake is the common European adder (Vipera berus). Here we present the case of a 53-year-old woman who was bitten by a common adder. Although the patient was initially in stable condition she developed edematous swelling of the complete lower limb, subcutaneous bleeding, and rhabdomyolysis. The aim of this report is to raise awareness that even in a central European country like Germany snake bites with a life-threatening course can occur and need immediate attention and medical care. PMID:25617003

  3. The LMF triaxial MITL voltage adder system

    SciTech Connect

    Mazarakis, M.G.; Smith, D.L.; Bennett, L.F.; Lockner, T.R.; Olson, R.E.; Poukey, J.W.

    1992-12-31

    The light-ion microfusion driver design consists of multiple accelerating modules fired in coincidence and sequentially in order to provide the desired ion energy, power pulse shape and energy deposition uniformity on an Inertial Confinement Fusion (ICF) target. The basic energy source is a number of Marx generators which, through the appropriate pulse power conditioning, provide the necessary voltage pulse wave form to the accelerating gaps or feeds of each module. The cavity gaps are inductively isolated, and the voltage addition occurs in the center conductor of the voltage adder which is the positive electrode while the electrons of the sheath flow closer to the outer cylinder which is the magnetically insulated cathode electrode. Each module powers a separate two-stage extraction diode which provides a low divergence ion beam. In order to provide the two separate voltage pulses required by the diode, a triaxial adder system is designed for each module. The voltage addition occurs in two separate MITLs. The center hollow cylinder (anode) of the second MITL also serves as the outer cathode electrode for the extension of the first voltage adder MITL. The voltage of the second stage is about twice that of the first stage. The cavities are connected in series to form the outer cylinder of each module. The accelerating modules are positioned radially in a symmetrical way around the fusion chamber. A preliminary conceptual design of the LMF modules with emphasis on the voltage adders and extension MITLs will be presented and discussed.

  4. Fast and area-efficient VLSI adders

    SciTech Connect

    Han, T.D.

    1987-01-01

    Area-time tradeoffs have been an important topic in VLSI research. This is because the cost of fabricating a circuit is an exponential function of its area. As a result, optimizing the area of a VLSI design is much more important than optimizing the speed of an algorithm. This dissertation examines area-time tradeoffs in VLSI for prefix computation using graph representations of the problem. Since the problem is intimately related to binary addition, results obtained lead to design of area-time efficient VLSI adders. This is a major goal of the work: to design very low latency-addition circuitry that is also area-efficient. To this end, a new graph representation is presented for prefix computation that leads to the design of a fast, area-efficient binary adder. The new graph is a combination of previously known graph representations for prefix computation, and its area is close to known lower bounds on the VLSI area of parallel prefix graphs. Using it, the author designed VLSI adders having area A = O(n log n) whose delay time is the lowest possible value, i.e., the fastest possible area-efficient VLSI adder. For the large number of inputs, the pipelined model of prefix circuit is presented. Also presented is a fault-tolerant model for the developed prefix circuit, based on the partitioning of the network.

  5. [A painful encounter with the weever (Echiichtis vipera)].

    PubMed

    van Otterdijk, F; de Vries, I; Meulenbelt, J

    1997-07-19

    The National Poisons Information Centre of the National Institute of Public Health and the Environment in the Netherlands in the past 2 years received dozens of requests for information about intoxication due to stings of the weever, Echiichtis vipera. The venomous apparatus of the weever consists of gill cover spines and 5 to 8 dorsal fin spines. The fish buries itself in the sandy or muddy bottom of the sea to wait for prey. The mixture of toxins that enters the skin upon contact with the spines causes a heavy local reaction, characterized mostly by pain, which untreated persists for 24 hours. An erythematous oedema may develop locally, spread over the entire extremity and persist for days. Systemic reactions are rare. Since the toxin mixture is heat labile, treatment is essentially simple: clean the wound and immerse the affected limb as soon as possible in warm water (45 degrees C) for 30 to 90 minutes. This makes the pain disappear. PMID:9542867

  6. A decimal carry-free adder

    NASA Astrophysics Data System (ADS)

    Nikmehr, Hooman; Phillips, Braden; Lim, Cheng-Chew

    2005-02-01

    Recently, decimal arithmetic has become attractive in the financial and commercial world including banking, tax calculation, currency conversion, insurance and accounting. Although computers are still carrying out decimal calculation using software libraries and binary floating-point numbers, it is likely that in the near future, all processors will be equipped with units performing decimal operations directly on decimal operands. One critical building block for some complex decimal operations is the decimal carry-free adder. This paper discusses the mathematical framework of the addition, introduces a new signed-digit format for representing decimal numbers and presents an efficient architectural implementation. Delay estimation analysis shows that the adder offers improved performance over earlier designs.

  7. An approach to the optical MSD adder

    NASA Astrophysics Data System (ADS)

    Takahashi, Hideya; Matsushita, Kenji; Shimizu, Eiji

    1990-07-01

    The intrinsic parallelism of optical elements for computation is presently taken fuller advantage of than heretofore possible through an optical implementation of the modified signed digit (MSD) number system, which yields carry-free addition and subtraction. In the present optical implementation of the MSD system, optical phase data are used to preclude negative value representation. Attention is given to an MSD adder array for addition operations on two n-digit trinary numbers; the output is composed of n + 1 trinary digits.

  8. Efficient radix-r adders for nanoelectronics

    NASA Astrophysics Data System (ADS)

    Moaiyeri, Mohammad Hossein; Chavoshisani, Reza; Jalali, Ali; Navi, Keivan; Hashemipour, Omid

    2016-02-01

    In this study, a new design method and efficient designs for radix-r adders are proposed for carbon nanotube field effect transistor (CNFET) FET nanotechnology. This application also investigates the capability of the nanoscale device for designing high-performance analogue circuits. The proposed designs benefit from the unique electrical properties of CNFET, such as near-ideal current voltage characteristics, very high transconductance, high-performance switches and very high-performance and high-gain binary inverters, at nanoscale. Moreover, adjustable threshold voltage and the same mobility of electrons and holes in a CNFET facilitate the design and modification procedures. The proposed design can be considered as an instance of a general adder, capable of adding radix-r digits with high precision. It is noteworthy that a very limited number of carbon nanotube diameters for designing the proposed adder are needed, which enhance the manufacturability. The proposed circuits are designed based on arithmetic relations and are also verified at 32 nm feature size using HSPICE and the Stanford standard SPICE model.

  9. A novel reversible carry-selected adder with low latency

    NASA Astrophysics Data System (ADS)

    Li, Ming-Cui; Zhou, Ri-Gui

    2016-07-01

    Reversible logic is getting more and more attention in quantum computing, optical computing, nanotechnology and low-power complementary metal oxide semiconductor designs since reversible circuits do not loose information during computation and have only small energy dissipation. In this paper, a novel carry-selected reversible adder is proposed primarily optimised for low latency. A 4-bit reversible full adder with two kinds of outputs, minimum delay and optimal quantum cost is presented as the building block for ?-bit reversible adder. Three new reversible gates NPG (new Peres gate), TEPG (triple extension of Peres gate) and RMUX21 (reversible 2-to-1 multiplexer) are proposed and utilised to design efficient adder units. The secondary carry propagation chain is carefully designed to reduce the time consumption. The novelty of the proposed design is the consideration of low latency. The comparative study shows that the proposed adder achieves the improvement from 61.46% to 95.29% in delay over the existing designs.

  10. Reproducible and controllable induction voltage adder for scaled beam experiments.

    PubMed

    Sakai, Yasuo; Nakajima, Mitsuo; Horioka, Kazuhiko

    2016-08-01

    A reproducible and controllable induction adder was developed using solid-state switching devices and Finemet cores for scaled beam compression experiments. A gate controlled MOSFET circuit was developed for the controllable voltage driver. The MOSFET circuit drove the induction adder at low magnetization levels of the cores which enabled us to form reproducible modulation voltages with jitter less than 0.3 ns. Preliminary beam compression experiments indicated that the induction adder can improve the reproducibility of modulation voltages and advance the beam physics experiments. PMID:27587112

  11. Low Power Adder Based Auditory Filter Architecture

    PubMed Central

    Jayanthi, V. S.

    2014-01-01

    Cochlea devices are powered up with the help of batteries and they should possess long working life to avoid replacing of devices at regular interval of years. Hence the devices with low power consumptions are required. In cochlea devices there are numerous filters, each responsible for frequency variant signals, which helps in identifying speech signals of different audible range. In this paper, multiplierless lookup table (LUT) based auditory filter is implemented. Power aware adder architectures are utilized to add the output samples of the LUT, available at every clock cycle. The design is developed and modeled using Verilog HDL, simulated using Mentor Graphics Model-Sim Simulator, and synthesized using Synopsys Design Compiler tool. The design was mapped to TSMC 65 nm technological node. The standard ASIC design methodology has been adapted to carry out the power analysis. The proposed FIR filter architecture has reduced the leakage power by 15% and increased its performance by 2.76%. PMID:25506073

  12. Half adder capabilities of a coupled quantum dot device.

    PubMed

    Pfeffer, P; Hartmann, F; Neri, I; Schade, A; Emmerling, M; Kamp, M; Gammaitoni, L; Höfling, S; Worschech, L

    2016-05-27

    In this paper we demonstrate two realizations of a half adder based on a voltage-rectifying mechanism involving two Coulomb-coupled quantum dots. First, we examine the ranges of operation of the half adder's individual elements, the AND and XOR gates, for a single rectifying device. It allows a switching between the two gates by a control voltage and thus enables a clocked half adder operation. The logic gates are shown to be reliably operative in a broad noise amplitude range with negligible error probabilities. Subsequently, we study the implementation of the half adder in a combined double-device consisting of two individually tunable rectifiers. We show that this double device allows a simultaneous operation of both relevant gates at once. The presented devices draw their power solely from electronic fluctuations and are therefore an advancement in the field of energy efficient and autonomous electronics. PMID:27079182

  13. [Envenomations].

    PubMed

    de Haro, L

    2000-02-15

    Although venomous animals are less frequent in Europe than in tropical countries, some dangerous species can be responsible of envenomations in France. Bites by two species of adders (Vipera aspis and Vipera berus) can lead to extensive swelling with multiorgan failure. Treatment is based on intravenous infusions of specific antivenom. Bites and stings by other animal species encountered in France are characterised by important pain with local signs like necrosis, bleeding or oedema: weevers, scorpion fish, centipedes, bees, wasps.... Contrary to scorpions of North Africa or India, the 5 scorpion species which live in France are completely harmless. Such is not the case with spiders: latrodectism (neurotoxicity) and loxoscelism (extensive necrosis) observed in Provence and in Corsica. PMID:10748672

  14. Inductive voltage adder (IVA) for submillimeter radius electron beam

    SciTech Connect

    Mazarakis, M.G.; Poukey, J.W.; Maenchen, J.E.

    1996-12-31

    The authors have already demonstrated the utility of inductive voltage adder accelerators for production of small-size electron beams. In this approach, the inductive voltage adder drives a magnetically immersed foilless diode to produce high-energy (10--20 MeV), high-brightness pencil electron beams. This concept was first demonstrated with the successful experiments which converted the linear induction accelerator RADLAC II into an IVA fitted with a small 1-cm radius cathode magnetically immersed foilless diode (RADLAC II/SMILE). They present here first validations of extending this idea to mm-scale electron beams using the SABRE and HERMES-III inductive voltage adders as test beds. The SABRE experiments are already completed and have produced 30-kA, 9-MeV electron beams with envelope diameter of 1.5-mm FWHM. The HERMES-III experiments are currently underway.

  15. Half adder capabilities of a coupled quantum dot device

    NASA Astrophysics Data System (ADS)

    Pfeffer, P.; Hartmann, F.; Neri, I.; Schade, A.; Emmerling, M.; Kamp, M.; Gammaitoni, L.; Höfling, S.; Worschech, L.

    2016-05-01

    In this paper we demonstrate two realizations of a half adder based on a voltage-rectifying mechanism involving two Coulomb-coupled quantum dots. First, we examine the ranges of operation of the half adder’s individual elements, the AND and XOR gates, for a single rectifying device. It allows a switching between the two gates by a control voltage and thus enables a clocked half adder operation. The logic gates are shown to be reliably operative in a broad noise amplitude range with negligible error probabilities. Subsequently, we study the implementation of the half adder in a combined double-device consisting of two individually tunable rectifiers. We show that this double device allows a simultaneous operation of both relevant gates at once. The presented devices draw their power solely from electronic fluctuations and are therefore an advancement in the field of energy efficient and autonomous electronics.

  16. Excitation of voltage oscillations in an induction voltage adder

    NASA Astrophysics Data System (ADS)

    Bruner, Nichelle; Genoni, Thomas; Madrid, Elizabeth; Welch, Dale; Hahn, Kelly; Oliver, Bryan

    2009-07-01

    The induction voltage adder is an accelerator architecture used in recent designs of pulsed-power driven x-ray radiographic systems such as Sandia National Laboratories’ Radiographic Integrated Test Stand (RITS), the Atomic Weapons Establishment’s planned Hydrus Facility, and the Naval Research Laboratory’s Mercury. Each of these designs relies on magnetic insulation to prevent electron loss across the anode-cathode gap in the vicinity of the adder as well as in the coaxial transmission line. Particle-in-cell simulations of the RITS adder and transmission line show that, as magnetic insulation is being established during a pulse, some electron loss occurs across the gap. Sufficient delay in the cavity pulse timings provides an opportunity for high-momentum electrons to deeply penetrate the cavities of the adder cells where they can excite radio-frequency resonances. These oscillations may be amplified in subsequent gaps, resulting in oscillations in the output power. The specific modes supported by the RITS-6 accelerator and details of the mechanism by which they are excited are presented in this paper.

  17. Optimized parity preserving quantum reversible full adder/subtractor

    NASA Astrophysics Data System (ADS)

    Haghparast, Majid; Bolhassani, Ali

    2016-07-01

    Reversible logic is one of the indispensable aspects of emerging technologies for reducing physical entropy gain, since reversible circuits do not lose information in the form of internal heat during computation. This paper aimed to initiate constructing parity preserving reversible circuits. A novel parity preserving reversible block, HB is presented. Then a new design of a cost-effective parity preserving reversible full adder/subtractor (PPFA/S) is proposed. Next, we suggested a new parity preserving binary to BCD converter. Finally, we proposed new realization of parity preserving reversible BCD adder. The proposed designs are cost-effective in terms of quantum cost and delay. All the scales are in the NANO-metric area.

  18. Inductive Adder Kicker Modulator for DARHT-II

    NASA Astrophysics Data System (ADS)

    Cook, Edward

    An all solid-state kicker modulator for the Dual-Axis Radiographic Hydrodynamic Test facility (DARHT-2) has been designed and tested. This kicker modulator uses multiple solid-state modules stacked in an inductive-adder configuration where the energy is switched into each section of the adder by a parallel array of MOSFETs. The modulator features very fast rise and fall times, pulse width agility and a high pulse-repetition rate in burst mode. The modulator can drive a 50* cable with voltages up to 20 kV and can be easily configured for either positive or negative polarity. The presentation will include test data collected from both the ETA II accelerator kicker and resistive dummy loads.

  19. Mitochondrial phylogeny shows multiple independent ecological transitions and northern dispersion despite of Pleistocene glaciations in meadow and steppe vipers (Vipera ursinii and Vipera renardi).

    PubMed

    Zinenko, Oleksandr; Stümpel, Nikolaus; Mazanaeva, Lyudmila; Bakiev, Andrey; Shiryaev, Konstantin; Pavlov, Aleksey; Kotenko, Tatiana; Kukushkin, Oleg; Chikin, Yury; Duisebayeva, Tatiana; Nilson, Göran; Orlov, Nikolai L; Tuniyev, Sako; Ananjeva, Natalia B; Murphy, Robert W; Joger, Ulrich

    2015-03-01

    The phylogeny and historical demography of small Eurasian vipers of the Vipera ursinii and V. renardi complexes were studied using mitochondrial DNA sequences analysed with Bayesian inference, Maximum Likelihood and Maximum Parsimony approaches, and mismatch distributions. Diversification in the group resulted from an initial dispersion in the later Pliocene - Pleistocene in two directions: north-westwards via the Balkans (V. ursinii complex) and north-eastwards from Asia Minor via the Caucasus (V. renardi complex). An independent, comparatively recent transition occurred from montane habitats to lowland grasslands in different mitochondrial lineages during the Late Pleistocene, when representatives of the both complexes had reached lowland steppes to the north. Effective population size showed clear signs of rapid growth in eastern V. renardi, triggered by colonization of vast lowland steppes, but in western V. ursinii complex grew during the Last Glaciation and experienced stabilization in Holocene. Expansion and population growth in lowland lineages of V. renardi was not strongly affected by Pleistocene climatic oscillations, when cold, dry conditions could have favoured species living in open grasslands. The high diversity of closely related haplotypes in the Caucasus and Tien-Shan could have resulted from repetitive expansion-constriction-isolation events in montane regions during Pleistocene climate fluctuations. The mitochondrial phylogeny pattern conflicts with the current taxonomy. PMID:25527984

  20. Ultrastructure of Myxidium trachinorum sp. nov. from the gallbladder of the lesser weever fish Echiichthys vipera.

    PubMed

    Canning, E U; Curry, A; Anderson, C L; Okamura, B

    1999-11-01

    Myxidium trachinorum sp. nov. is described from the gallbladder of the lesser weever fish Echiichthys vipera. Pseudoplasmodia attach themselves to the gallbladder epithelium by filose processes, which are inserted between host cells. Pseudoplasmodia undergo endogenous cell formation at the secondary and tertiary levels. In the proliferative cycle, primary and endogenous cells are packed with digestive vacuoles formed by phagocytosis. In the sporogonic cycle the pseudoplasmodium becomes a pericyte enclosing two secondary cells (lacking digestive vacuoles) in a vacuole. These give rise to five cells each two valvogenic, two capsulogenic and a binucleate sporoplasm, which mature into spores. Comparison of the disporic M. trachinorum with polysporic species of Myxidium revealed significant differences in plasmodial ultrastructure, especially their attachments to host cells, surface characteristics and mode of nutrition, and in formation of generative cells. These suggest that the genus Myxidium may require revision. PMID:10540952

  1. Purification and characterization of an organ specific haemorrhagic toxin from Vipera russelli russelli (Russell's viper) venom.

    PubMed

    Kole, L; Chakrabarty, D; Datta, K; Bhattacharyya, D

    2000-04-01

    A haemorrhagic toxin (VRR-12) from Vipera russelli russelli (Russell's viper) venom has been purified by ion-exchange chromatography on CM-Sephadex C-50 followed by size-exclusion HPLC to electrophoretically homogeneous state. It is a 12 kDa single polypeptide having 1 mole of Zn+2 ion. This toxin induces intense intestinal haemorrhage and to a lesser extent skeletal muscle haemorrhage in mice. It does not show detectable proteolytic and esterolytic activity with selected substrates under specified conditions, haemolytic and phospholipase activity. When VRR-12, preincubated with bivalent antiserum against Saw-scaled and Russell's viper venom or EDTA was injected, haemorrhagic activity was not reduced, on the other hand preincubation with phenylmethyl sulphonyl fluoride reduced the activity markedly. Biodistribution studies with 125I VRR-12 show that haemorrhagic manifestation by this toxin is not a direct function of the fraction of the totally administered toxin distributed to that tissue. PMID:10983422

  2. Venomics and antivenomics profiles of North African Cerastes cerastes and C. vipera populations reveals a potentially important therapeutic weakness.

    PubMed

    Fahmi, Laila; Makran, Bouchra; Pla, Davinia; Sanz, Libia; Oukkache, Naoual; Lkhider, Mustapha; Harrison, Robert A; Ghalim, Noreddine; Calvete, Juan J

    2012-04-18

    We report the proteomic analysis of the venom of the medically relevant snake, Cerastes cerastes, from Morocco, and the immunoreactivity profile of an experimental monospecific (CcMo_AV against Moroccan C. cerastes venom) and a commercial (Gamma-VIP against Tunisian C. cerastes and M. lebetina venoms) F(ab')(2) antivenoms towards geographic variants of C. cerastes and C. vipera venoms. The venom of C. cerastes is a low-complexity proteome composed of 25-30 toxins belonging to 6 protein families, mainly targetting the hemostatic system. This toxin arsenal explains the clinical picture observed in C. cerastes envenomings. Despite geographic compositional variation, the monospecific CcMo_AV and the Gamma-VIP divalent antivenom produced at Institut Pasteur de Tunis, showed similar immunocapturing capability towards Moroccan, Tunisian, and Egyptian C. cerastes venom proteins. Proteins partially escaping immunorecognition were all identified as PLA(2) molecules. Antivenomic analysis showed low degree of cross-reactivity of Moroccan CcMo_AV and Tunisian Gamma-VIP antivenoms towards C. vipera venom toxins. This study indicates that a more complete therapeutic cover could be achieved by including C. vipera venom in the formulation of venom immunization mixtures, thereby generating a pan-Cerastes antivenom. PMID:22387316

  3. Influence of climate on the presence of colour polymorphism in two montane reptile species.

    PubMed

    Broennimann, Olivier; Ursenbacher, Sylvain; Meyer, Andreas; Golay, Philippe; Monney, Jean-Claude; Schmocker, Hans; Guisan, Antoine; Dubey, Sylvain

    2014-11-01

    The coloration of ectotherms plays an important role in thermoregulation processes. Dark individuals should heat up faster and be able to reach a higher body temperature than light individuals and should therefore have benefits in cool areas. In central Europe, montane local populations of adder (Vipera berus) and asp viper (Vipera aspis) exhibit a varying proportion of melanistic individuals. We tested whether the presence of melanistic V. aspis and V. berus could be explained by climatic conditions. We measured the climatic niche position and breadth of monomorphic (including strictly patterned individuals) and polymorphic local populations, calculated their niche overlap and tested for niche equivalency and similarity. In accordance with expectations, niche overlap between polymorphic local populations of both species is high, and even higher than that of polymorphic versus monomorphic montane local populations of V. aspis, suggesting a predominant role of melanism in determining the niche of ectothermic vertebrates. However, unexpectedly, the niche of polymorphic local populations of both species is narrower than that of monomorphic ones, indicating that colour polymorphism does not always enable the exploitation of a greater variability of resources, at least at the intraspecific level. Overall, our results suggest that melanism might be present only when the thermoregulatory benefit is higher than the cost of predation. PMID:25392313

  4. Low power adder based digital filter for QRS detector.

    PubMed

    Murali, L; Chitra, D; Manigandan, T

    2014-01-01

    Most of the Biomedical applications use dedicated processors for the implementation of complex signal processing. Among them, sensor network is also a type, which has the constraint of low power consumption. Since the processing elements are the most copiously used operations in the signal processors, the power consumption of this has the major impact on the system level application. In this paper, we introduce low power concept of transistor stacking to reduce leakage power; and new architectures based on stacking to implement the full adder and its significance at the digital filter level for QRS detector are implemented. The proposed concept has lesser leakage power at the adder as well as filter level with trade-off in other quality metrics of the design. This enabled the design to be dealt with as the low-power corner and can be made adaptable to any level of hierarchical abstractions as per the requirement of the application. The proposed architectures are designed, modeled at RTL level using the Verilog-HDL, and synthesized in Synopsys Design Compiler by mapping the design to 65 nm technology library standard cells. PMID:24895649

  5. Quantitative transformation for implementation of adder circuits in physical systems.

    PubMed

    Jones, Jeff; Whiting, James G H; Adamatzky, Andrew

    2015-08-01

    Computing devices are composed of spatial arrangements of simple fundamental logic gates. These gates may be combined to form more complex adding circuits and, ultimately, complete computer systems. Implementing classical adding circuits using unconventional, or even living substrates such as slime mould Physarum polycephalum, is made difficult and often impractical by the challenges of branching fan-out of inputs and regions where circuit lines must cross without interference. In this report we explore whether it is possible to avoid spatial propagation, branching and crossing completely in the design of adding circuits. We analyse the input and output patterns of a single-bit full adder circuit. A simple quantitative transformation of the input patterns which considers the total number of bits in the input string allows us to map the respective input combinations to the correct outputs patterns of the full adder circuit, reducing the circuit combinations from a 2:1 mapping to a 1:1 mapping. The mapping of inputs to outputs also shows an incremental linear progression, suggesting its implementation in a range of physical systems. We demonstrate an example implementation, first in simulation, inspired by self-oscillatory dynamics of the acellular slime mould P. polycephalum. We then assess the potential implementation using plasmodium of slime mould itself. This simple transformation may enrich the potential for using unconventional computing substrates to implement digital circuits. PMID:26007225

  6. Mixed logic style adder circuit designed and fabricated using SOI substrate for irradiation-hardened experiment

    NASA Astrophysics Data System (ADS)

    Yuan, Shoucai; Liu, Yamei

    2016-08-01

    This paper proposed a rail to rail swing, mixed logic style 28-transistor 1-bit full adder circuit which is designed and fabricated using silicon-on-insulator (SOI) substrate with 90 nm gate length technology. The main goal of our design is space application where circuits may be damaged by outer space radiation; so the irradiation-hardened technique such as SOI structure should be used. The circuit's delay, power and power-delay product (PDP) of our proposed gate diffusion input (GDI)-based adder are HSPICE simulated and compared with other reported high-performance 1-bit adder. The GDI-based 1-bit adder has 21.61% improvement in delay and 18.85% improvement in PDP, over the reported 1-bit adder. However, its power dissipation is larger than that reported with 3.56% increased but is still comparable. The worst case performance of proposed 1-bit adder circuit is also seen to be less sensitive to variations in power supply voltage (VDD) and capacitance load (CL), over a wide range from 0.6 to 1.8 V and 0 to 200 fF, respectively. The proposed and reported 1-bit full adders are all layout designed and wafer fabricated with other circuits/systems together on one chip. The chip measurement and analysis has been done at VDD = 1.2 V, CL = 20 fF, and 200 MHz maximum input signal frequency with temperature of 300 K.

  7. [A Rare Case in Hand Surgery: Adder Bite in an Index Finger].

    PubMed

    Jaehn, T; Zunker, C; Mägdefrau, H; Reichert, B

    2016-08-01

    The common European adder is an endangered animal species in Europe. Despite its endangerment, snake bite injuries do occur from time to time, even in Germany. This is a poisoning emergency. Detailed numbers concerning the incidence or lethality of adder bites in Germany do not exist. Only 13% of all cases have a severe course of disease, with children and elderly people prevailing in this patient group. We report the benign course of an adder bite injury of the index finger of a 60-year-old zoologist, which healed completely under symptomatic treatment and surveillance without any operative intervention. PMID:27442002

  8. Identification of proteins interacting with ammodytoxins in Vipera ammodytes ammodytes venom by immuno-affinity chromatography.

    PubMed

    Brgles, Marija; Kurtović, Tihana; Kovačič, Lidija; Križaj, Igor; Barut, Miloš; Lang Balija, Maja; Allmaier, Günter; Marchetti-Deschmann, Martina; Halassy, Beata

    2014-01-01

    In order to perform their function, proteins frequently interact with other proteins. Various methods are used to reveal protein interacting partners, and affinity chromatography is one of them. Snake venom is composed mostly of proteins, and various protein complexes in the venom have been found to exhibit higher toxicity levels than respective components separately. Complexes can modulate envenomation activity of a venom and/or potentiate its effect. Our previous data indicate that the most toxic components of the Vipera ammodytes ammodytes (Vaa) venom isolated so far-ammodytoxins (Atxs)-are contributing to the venom's toxicity only moderately; therefore, we aimed to explore whether they have some interacting partner(s) potentiating toxicity. For screening of possible interactions, immuno-affinity chromatography combined with identification by mass spectrometry was used. Various chemistries (epoxy, carbonyldiimidazole, ethylenediamine) as well as protein G functionality were used to immobilize antibodies on monolith support, a Convective Interaction Media disk. Monoliths have been demonstrated to better suit the separation of large biomolecules. Using such approach, several proteins were indicated as potential Atx-binding proteins. Among these, the interaction of Atxs with a Kunitz-type inhibitor was confirmed by far-Western dot-blot and surface plasmon resonance measurement. It can be concluded that affinity chromatography on monolithic columns combined with mass spectrometry identification is a successful approach for screening of protein interactions and it resulted with detection of the interaction of Atx with Kunitz-type inhibitor in Vaa venom for the first time. PMID:24217948

  9. Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice

    PubMed Central

    Dyachenko, Igor A; Murashev, Arkadii N; Andreeva, Tatyana V; Tsetlin, Victor I; Utkin, Yuri N

    2013-01-01

    Phospholipases A2 are represented in snake venoms by several types and possess diverse biological activities including neurotoxicity. Previously, we isolated and characterized two neurotoxic phospholipases A2 (HDP-1 and HDP-2) from the venom of Nikolski's viper (Vipera nikolskii), which were heterodimers composed of two non-covalently bound subunits. Each heterodimer consisted of an enzymatically active basic subunit and an inactive acidic subunit. In this work, we studied the in vivo biological activity of HDP-2 in mice. The acute toxicity (LD50 = 0.38 μg/gm) and maximal tolerated dose (0.1 μg/gm) were determined. In the hot plate test, HDP-2 at the maximal tolerated dose, reliably prolonged the time of the mouse staying on the plate. However, taking into account the neurotoxicity of HDP-2, we believe that this effect may be explained by a general intoxication rather than specific decrease of pain sensitivity. In this respect HDP-2 differs from other heterodimeric phospholipases A2 like crotoxin, which possess analgesic activity. This difference can be explained by the dissimilarity in the structure of the acidic subunits, suggesting an important role of this subunit in analgesic activity. PMID:23577231

  10. Simple novel all-optical half-adder

    NASA Astrophysics Data System (ADS)

    Chen, Zhixin

    2010-04-01

    On the basis of Sagnac interferometric structure, a simple novel ultrafast scheme of all-optical half-adder is proposed. The structure comprises two of the same balanced terahertz optical asymmetric demultiplexers (TOADs). One TOAD is utilized to achieve an all-optical XOR gate, which is logic SUM. The other is utilized to obtain an all-optical AND gate, which is logic CARRY. Logical SUM and CARRY are simultaneously realized at 80 Gbit/s. Through numerical analysis, the operating characteristics of the scheme are illustrated at 80 Gbit/s. Furthermore, the carrier recovery time of the semiconductor optical amplifier is no longer a crucial parameter to restrict the operation speed of this scheme.

  11. Bit-Serial Adder Based on Quantum Dots

    NASA Technical Reports Server (NTRS)

    Fijany, Amir; Toomarian, Nikzad; Modarress, Katayoon; Spotnitz, Mathew

    2003-01-01

    A proposed integrated circuit based on quantum-dot cellular automata (QCA) would function as a bit-serial adder. This circuit would serve as a prototype building block for demonstrating the feasibility of quantum-dots computing and for the further development of increasingly complex and increasingly capable quantum-dots computing circuits. QCA-based bit-serial adders would be especially useful in that they would enable the development of highly parallel and systolic processors for implementing fast Fourier, cosine, Hartley, and wavelet transforms. The proposed circuit would complement the QCA-based circuits described in "Implementing Permutation Matrices by Use of Quantum Dots" (NPO-20801), NASA Tech Briefs, Vol. 25, No. 10 (October 2001), page 42 and "Compact Interconnection Networks Based on Quantum Dots" (NPO-20855), which appears elsewhere in this issue. Those articles described the limitations of very-large-scale-integrated (VLSI) circuitry and the major potential advantage afforded by QCA. To recapitulate: In a VLSI circuit, signal paths that are required not to interact with each other must not cross in the same plane. In contrast, for reasons too complex to describe in the limited space available for this article, suitably designed and operated QCA-based signal paths that are required not to interact with each other can nevertheless be allowed to cross each other in the same plane without adverse effect. In principle, this characteristic could be exploited to design compact, coplanar, simple (relative to VLSI) QCA-based networks to implement complex, advanced interconnection schemes. To enable a meaningful description of the proposed bit-serial adder, it is necessary to further recapitulate the description of a quantum-dot cellular automation from the first-mentioned prior article: A quantum-dot cellular automaton contains four quantum dots positioned at the corners of a square cell. The cell contains two extra mobile electrons that can tunnel (in the

  12. Design of Efficient Full Adder in Quantum-Dot Cellular Automata

    PubMed Central

    Sen, Bibhash; Sikdar, Biplab K.

    2013-01-01

    Further downscaling of CMOS technology becomes challenging as it faces limitation of feature size reduction. Quantum-dot cellular automata (QCA), a potential alternative to CMOS, promises efficient digital design at nanoscale. Investigations on the reduction of QCA primitives (majority gates and inverters) for various adders are limited, and very few designs exist for reference. As a result, design of adders under QCA framework is gaining its importance in recent research. This work targets developing multi-layered full adder architecture in QCA framework based on five-input majority gate proposed here. A minimum clock zone (2 clock) with high compaction (0.01 μm2) for a full adder around QCA is achieved. Further, the usefulness of such design is established with the synthesis of high-level logic. Experimental results illustrate the significant improvements in design level in terms of circuit area, cell count, and clock compared to that of conventional design approaches. PMID:23844385

  13. A new species of death adder (Acanthophis: Serpentes: Elapidae) from north-western Australia.

    PubMed

    Maddock, Simon T; Ellis, Ryan J; Doughty, Paul; Smith, Lawrence A; Wüster, Wolfgang

    2015-01-01

    Australian death adders (genus Acanthophis) are highly venomous snakes with conservative morphology and sit-and-wait predatory habits, with only moderate taxonomic diversity that nevertheless remains incompletely understood. Analyses of mitochondrial and nuclear gene sequences and morphological characteristics of death adders in northern Australia reveal the existence of a new species from the Kimberley region of Western Australia and the Northern Territory, which we describe as Acanthophis cryptamydros sp. nov. Although populations from the Kimberley were previously considered conspecific with Northern Territory death adders of the A. rugosus complex, our mtDNA analysis indicates that its closest relatives are desert death adders, A. pyrrhus. We found that A. cryptamydros sp. nov. is distinct in both mtDNA and nDNA analysis, and possesses multiple morphological characteristics that allow it to be distinguished from all other Acanthophis species. This study further supports the Kimberley region as an area with high endemic biodiversity. PMID:26623813

  14. Towards constructing multi-bit binary adder based on Belousov-Zhabotinsky reaction

    NASA Astrophysics Data System (ADS)

    Zhang, Guo-Mao; Wong, Ieong; Chou, Meng-Ta; Zhao, Xin

    2012-04-01

    It has been proposed that the spatial excitable media can perform a wide range of computational operations, from image processing, to path planning, to logical and arithmetic computations. The realizations in the field of chemical logical and arithmetic computations are mainly concerned with single simple logical functions in experiments. In this study, based on Belousov-Zhabotinsky reaction, we performed simulations toward the realization of a more complex operation, the binary adder. Combining with some of the existing functional structures that have been verified experimentally, we designed a planar geometrical binary adder chemical device. Through numerical simulations, we first demonstrated that the device can implement the function of a single-bit full binary adder. Then we show that the binary adder units can be further extended in plane, and coupled together to realize a two-bit, or even multi-bit binary adder. The realization of chemical adders can guide the constructions of other sophisticated arithmetic functions, ultimately leading to the implementation of chemical computer and other intelligent systems.

  15. In vitro screening and evaluation of antivenom phytochemicals from Azima tetracantha Lam. leaves against Bungarus caeruleus and Vipera russelli

    PubMed Central

    2014-01-01

    Background Snakebites are considered a neglected tropical disease that affects thousands of people worldwide. Although antivenom is the only treatment available, it is associated with several side effects. As an alternative, plants have been extensively studied in order to obtain an alternative treatment. In folk medicine, Azima tetracantha Lam. is usually used to treat snakebites. The present study aims to provide a scientific explanation for the use of this plant against snakebite. The extracts of shade dried leaves of A. tetracantha were tested for in vitro inhibitory activity on toxic venom enzymes like phosphomonoesterase, phosphodiesterase, acetylcholinesterase, hyaluronidase etc. from Bungarus caeruleus and Vipera russelli venoms. Results The ethylacetate extract rendered a significant inhibitory effect on the phosphomonoesterase, phosphodiesterase, phospholipase A2 and acetylcholinesterase enzymes. Conclusions The present study suggests that ethylacetate extract of A. tetracantha leaves possesses compounds that inhibit the activity of toxic enzymes from Bungarus caeruleus and Vipera russelli venom. Further pharmacological and in vivo studies would provide evidence that this substance may lead to a potential treatment against these venoms. PMID:24690426

  16. Design of RSFQ wave pipelined Kogge-Stone Adder and developing custom compound gates

    NASA Astrophysics Data System (ADS)

    Ozer, M.; Eren Çelik, M.; Tukel, Y.; Bozbey, A.

    2014-09-01

    Since the invention of computers, the calculation of arithmetic and logic operations using digital circuits has been one of the leading problems in processor designs. The challenge has been to compute more operations with less clock cycles by using additional specific logic circuits. One of the most fundamental processes is addition; in which the carry bit should be transferred from the least significant bit to the most significant one. A wide range of digital circuit designs have been sustained for specialized faster addition operation. One of these adder algorithms is Kogge Stone Adder which does faster calculation with fewer levels and minimum fan-out compared to today’s adders despite the only disadvantage of having an excessive amount of wiring. In this study, a custom Rapid Single Flux Quantum (RSFQ) based, wave pipelined, Kogge Stone Adder is proposed to be used later in an Arithmetic Logic Unit (ALU). Two different design methodologies have been considered. In the first approach, we used standard logic gates for the whole adder design. In the second approach, utilization to compound gate design with adjustments over component parameters is done by using Particle Swarm Optimization and Statistical Timing Analysis Tools, to increase both efficiency and bias margin.

  17. Multiple-Valued Constant-Power Adder and Its Application to Cryptographic Processor

    NASA Astrophysics Data System (ADS)

    Homma, Naofumi; Baba, Yuichi; Miyamoto, Atsushi; Aoki, Takafumi

    This paper proposes a constant-power adder based on multiple-valued logic and its application to cryptographic processors being resistant to side-channel attacks. The proposed adder is implemented in Multiple-Valued Current-Mode Logic (MV-CML). The important feature of MV-CML is that the power consumption can be constant regardless of input values, which makes it possible to prevent power-analysis attacks using dependencies between power consumption and intermediate values or operations of the executed cryptographic algorithms. In this paper, we focus on a multiple-valued Binary Carry-Save adder based on the Positive-Digit (PD) number system and its application to RSA processors. The power characteristic of the proposed design is evaluated with HSPICE simulation using 90nm process technology. The result shows that the proposed design can achieve constant power consumption with lower performance overhead in comparison with the conventional binary design.

  18. Inductive voltage adder advanced hydrodynamic radiographic technology demonstration

    SciTech Connect

    Mazarakis, M.G.; Poukey, J.W.; Maenchen; Rovang, D.C.

    1997-04-01

    This paper presents the design, results, and analysis of a high-brightness electron beam technology demonstration experiment completed at Sandia National Laboratories, performed in collaboration with Los Alamos National Laboratory. The anticipated electron beam parameters were: 12 MeV, 35-40 kA, 0.5-mm rms radius, and 40-ns full width half maximum (FWHM) pulse duration. This beam, on an optimum thickness tantalum converter, should produce a very intense x-ray source of {approximately} 1.5-mm spot size and 1 kR dose @ 1 m. The accelerator utilized was SABRE, a pulsed inductive voltage adder, and the electron source was a magnetically immersed foilless electron diode. For these experiments, SABRE was modified to high-impedance negative-polarity operation. A new 100-ohm magnetically insulated transmission line cathode electrode was designed and constructed; the cavities were rotated 180{degrees} poloidally to invert the central electrode polarity to negative; and only one of the two pulse forming lines per cavity was energized. A twenty- to thirty-Tesla solenoidal magnet insulated the diode and contained the beam at its extremely small size. These experiments were designed to demonstrate high electron currents in submillimeter radius beams resulting in a high-brightness high-intensity flash x-ray source for high-resolution thick-object hydrodynamic radiography. The SABRE facility high-impedance performance was less than what was hoped. The modifications resulted in a lower amplitude (9 MV), narrower-than-anticipated triangular voltage pulse, which limited the dose to {approximately} 20% of the expected value. In addition, halo and ion-hose instabilities increased the electron beam spot size to > 1.5 mm. Subsequent, more detailed calculations explain these reduced output parameters. An accelerator designed (versus retrofit) for this purpose would provide the desired voltage and pulse shape.

  19. Development of an Adder-Topology ILC Damping Ring Kicker Modulator

    SciTech Connect

    Tang, Tao; Burkhart, Craig; /SLAC

    2009-05-08

    The ILC damping ring injection and extraction kickers will require high availability modulators that can deliver {+-}5 kV pulses into 50 {Omega} with a 2 ns flattop ({approx}1 ns rise and fall time) at up to 6 MHz. An effort is underway at SLAC National Accelerator Laboratory to meet these requirements using a transmission line adder topology to combine the output of an array of {approx}1 kV modules. The modules employ an ultra-fast hybrid MOSFET/driver that can switch 33 A in 1.2 ns. Experimental results for a scale adder structure are presented.

  20. The symmetric MSD encoder for one-step adder of ternary optical computer

    NASA Astrophysics Data System (ADS)

    Kai, Song; LiPing, Yan

    2016-08-01

    The symmetric Modified Signed-Digit (MSD) encoding is important for achieving the one-step MSD adder of Ternary Optical Computer (TOC). The paper described the symmetric MSD encoding algorithm in detail, and developed its truth table which has nine rows and nine columns. According to the truth table, the state table was developed, and the optical-path structure and circuit-implementation scheme of the symmetric MSD encoder (SME) for one-step adder of TOC were proposed. Finally, a series of experiments were designed and performed. The observed results of the experiments showed that the scheme to implement SME was correct, feasible and efficient.

  1. Power efficient, clock gated multiplexer based full adder cell using 28 nm technology

    NASA Astrophysics Data System (ADS)

    Gupta, Ashutosh; Murgai, Shruti; Gulati, Anmol; Kumar, Pradeep

    2016-03-01

    Clock gating is a leading technique used for power saving. Full adders is one of the basic circuit that can be found in maximum VLSI circuits. In this paper clock gated multiplexer based full adder cell is implemented on 28 nm technology. We have designed a full adder cell using a multiplexer with a gated clock without degrading its performance of the cell. We have negative latch circuit for generating gated clock. This gated clock is used to control the multiplexer based full adder cell. The circuit has been synthesized on kintex FPGA through Xilinx ISE Design Suite 14.7 using 28 nm technology in Verilog HDL. The circuit has been simulated on Modelsim 10.3c. The design is verified using System Verilog on QuestaSim in UVM environment. The total power of the circuit has been reduced by 7.41% without degrading the performance of original circuit. The power has been calculated using XPower Analyzer tool of XILINX ISE DESIGN SUITE 14.3.

  2. A modified prefix operator well suited for area-efficient brick-based adder implementations

    NASA Astrophysics Data System (ADS)

    Rust, I.; Noll, T. G.

    2011-08-01

    The implementation of integrated circuits becomes more and more difficult in the Ultra-Deep-Submicron regime due to sub-wavelength lithography issues. An approach called Brick-Based Design was recently proposed to eliminate the disadvantages of staying with the classical approach to layout design. Prefix adders are a core component in a wide variety of applications due to their high speed and regular topology. In this paper, a modified prefix operator for prefix adders is proposed which is well suited for brick-style layout implementation and, in addition, offers an increase in efficiency. The proposed operator makes it possible to use a mirror gate for the generation of both generate and propagate signals, which exhibits a forbidden input signal combination. This "forbidden state" causes an increase in power dissipation due to transient short circuit currents. The effect of the forbidden state was quantified as part of a comparison against the classical prefix operator, based on 64-bit Sklansky adders implemented in a 40-nm CMOS technology. The effects of the forbidden state were found to be well acceptable. The implementation of the adder based on the proposed prefix operator reduces the area by 29% while increasing the power by 13% compared to one based on the classical operator.

  3. Morphology, Reproduction and Diet in Australian and Papuan Death Adders (Acanthophis, Elapidae)

    PubMed Central

    Shine, Richard; Spencer, Carol L.; Keogh, J. Scott

    2014-01-01

    Death adders (genus Acanthophis) differ from most other elapid snakes, and resemble many viperid snakes, in their thickset morphology and ambush foraging mode. Although these snakes are widely distributed through Australia and Papua New Guinea, their basic biology remains poorly known. We report morphological and ecological data based upon dissection of >750 museum specimens drawn from most of the range of the genus. Female death adders grow larger than conspecific males, to about the same extent in all taxa (20% in mean adult snout-vent length,  =  SVL). Most museum specimens were adult rather than juvenile animals, and adult males outnumbered females in all taxa except A. pyrrhus. Females have shorter tails (relative to SVL) than males, and longer narrower heads (relative to head length) in some but not all species. The southern A. antarcticus is wider-bodied (relative to SVL) than the other Australian species. Fecundity of these viviparous snakes was similar among taxa (mean litter sizes 8 to 14). Death adders encompass a broad range of ecological attributes, taking a wide variety of vertebrate prey, mostly lizards (55%), frogs and mammals (each 21%; based on 217 records). Dietary composition differed among species (e.g. frogs were more common in tropical than temperate-zone species), and shifted with snake body size (endotherms were taken by larger snakes) and sex (male death adders took more lizards than did females). Overall, death adders take a broader array of prey types, including active fast-moving taxa such as endotherms and large diurnal skinks, than do most other Australian elapids of similar body sizes. Ambush foraging is the key to capturing such elusive prey. PMID:24718608

  4. A rapid single flux quantum 1 bit arithmetic logic unit constructed with a half-adder cell

    NASA Astrophysics Data System (ADS)

    Jung, K. R.; Kim, J. Y.; Kang, J. H.; Kirichenko, A. F.; Park, J. H.; Hahn, T. S.

    2004-06-01

    We have designed, fabricated, and tested a rapid single flux quantum (RSFQ) 1 bit arithmetic logic unit (ALU) block. The circuit consists of three DC current driven SFQ switches and a half-adder. We successfully tested the half-adder cell at clock frequency up to 20 GHz. The switches were commutating output ports of the half-adder to produce AND, OR, XOR, or ADD functions. For a high-speed test, we attached two switches at the input ports of the half-adder to control the high-speed input data by low-frequency pattern generators. The output in this measurement was an eye-diagram. Using this set-up, the circuit was successfully tested up to 20 GHz. The chip was fabricated using a standard HYPRES 1 kA cm-2 Nb Josephson junction fabrication process.

  5. Purification and Characterization of a New Serine Protease (VLCII) Isolated from Vipera lebetina Venom: Its Role in Hemostasis.

    PubMed

    Amel, Kadi-Saci; Fatima, Laraba-Djebari

    2015-08-01

    Snake venom serine proteinases (SVSPs) affect various physiological functions including blood coagulation, fibrinolysis, and platelet aggregation. Coagulant serine proteinase (VLCII) was purified from Vipera lebetina venom using three chromatographic steps: gel filtration on SephadexG-75, DEAE-Sephadex A-50, and reversed-phase high-performance liquid chromatography (RP-HPLC) on C8 column. VLCII appeared homogenous (60 kDa) when tested on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). VLCII as a thrombin-like enzyme was able to hydrolyze Nα-CBZ L-arginine-p-nitroanilide hydrochloride and could be a serine protease because it is inhibited by phenylmethylsulfonyl fluoride. The proteolytic activity of VLCII was not affected by ethylenediaminetetraacetic acid and 1.10-phenanthroline. It showed high coagulant activity against human plasma and cleaved both Aα chain and Bβ chain of bovine fibrinogen. The isolated VLCII displayed proaggregating effect on human platelet in a concentration-dependent manner with an absence of lag time. Clopidogrel P2Y12 adenosine diphosphate (ADP) receptor inhibitor reduced markedly the aggregating effect induced by VLCII than aspirin, indicating the involvement of ADP signaling pathway. PMID:25917874

  6. Pathophysiological effects of Cerastes cerastes and Vipera lebetina venoms: Immunoneutralization using anti-native and anti-(60)Co irradiated venoms.

    PubMed

    Boumaiza, Sabrina; Oussedik-Oumehdi, Habiba; Laraba-Djebari, Fatima

    2016-01-01

    Cerastes cerastes and Vipera lebetina are the most medically important vipers in Algeria. Their bite induces several pathological effects on victims of accidental envenomation. In this study we analyzed the pathogenesis induced after an experimental envenomation. Indeed, we determined, in vitro, venom enzymatic activities and we analyzed, in vivo, pathological effects induced on liver, heart, lung and skin. In addition we investigated the neutralizing potency of four experimental antivenoms elicited against native and irradiated venoms. Results revealed that V. lebetina and Cerastes cerastes venoms presented strong hemorrhagic, oedematic and necrotic activities. Histopathological study showed that both venoms induced deep damage in tissue structures leading to organ dysfunction. They also increased cellular peroxidases activities, indicating an inflammatory process that is known to amplify tissue damage. Western-blot analysis evidenced that anti-irradiated venoms recognized most components of native venoms. Antivenoms were effective in neutralizing all tested activities, with an increased protective effect obtained with anti-irradiated venoms. Anti-irradiated venoms reduced cellular peroxidases activities indicating a reduction of the inflammatory response. These results may improve our understanding of Algerian Viperidae bite pathogenesis and would encourage further studies planning to provide more proofs on the effectiveness of anti-irradiated venoms administration in the treatment of envenomation. PMID:26678662

  7. DNA based arithmetic function: a half adder based on DNA strand displacement.

    PubMed

    Li, Wei; Zhang, Fei; Yan, Hao; Liu, Yan

    2016-02-14

    Biomolecular programming utilizes the reactions and information stored in biological molecules, such as proteins and nucleic acids, for computational purposes. DNA has proven itself an excellent candidate for building logic operating systems due to its highly predictable molecular behavior. In this work we designed and realized an XOR logic gate and an AND logic gate based on DNA strand displacement reactions. These logic gates utilize ssDNA as input and output signals. The XOR gate and the AND gate were used as building blocks for constructing a half adder logic circuit, which is a primary step in constructing a full adder, a basic arithmetic unit in computing. This work provides the field of DNA molecular programming with a potential universal arithmetic tool. PMID:26814628

  8. Modeling of an Inductive Adder Kicker Pulser For DARHT-II

    NASA Astrophysics Data System (ADS)

    Wang, Li-Fang

    An all solid-state kicker pulser for a high current induction accelerator (the Dual-Axis Radiographic Hydrodynamic Test facility DARHT-2) has been designed and fabricated. This kicker pulser uses multiple solid state modulators stacked in an inductive-adder configuration. Each modulator is comprised of multiple metal-oxide-semiconductor field-effect transistors (MOSFETs) which quickly switch the energy storage capacitors across a magnetic induction core. Metglas is used as the core material to minimize loss. Voltage from each modulator is inductively added by a voltage summing stalk and delivered to a 50 ohm output cable. A lumped element circuit model of the inductive adder has been developed to optimize the performance of the pulser. Results for several stalk geometries will be compared with experimental data.

  9. Butterfly interconnection implementation for an n-bit parallel ripple carry full adder.

    PubMed

    Sun, D G; Weng, Z H

    1991-05-10

    Free-space optical interconnections are important both in massive digital optical computing and in communication systems. The optical butterfly interconnection has many advantages over other interconnections in implementing various basic logic functions such as addition, subtraction, multiplication. This paper starts with the conventional Karnaugh maps and Boolean algebra to implement a parallel n-bit ripple carry full adder by the use of multilayer butterfly interconnection networks. Then we describe in detail the design and architecture of the full adder and provide accurate interconnection networks and the structures or patterns of key devices such as the masks to implement AND and OR operations in this calculation. Finally, we discuss development of the interconnection in implementing logic operations. PMID:20700358

  10. DNA based arithmetic function: a half adder based on DNA strand displacement

    NASA Astrophysics Data System (ADS)

    Li, Wei; Zhang, Fei; Yan, Hao; Liu, Yan

    2016-02-01

    Biomolecular programming utilizes the reactions and information stored in biological molecules, such as proteins and nucleic acids, for computational purposes. DNA has proven itself an excellent candidate for building logic operating systems due to its highly predictable molecular behavior. In this work we designed and realized an XOR logic gate and an AND logic gate based on DNA strand displacement reactions. These logic gates utilize ssDNA as input and output signals. The XOR gate and the AND gate were used as building blocks for constructing a half adder logic circuit, which is a primary step in constructing a full adder, a basic arithmetic unit in computing. This work provides the field of DNA molecular programming with a potential universal arithmetic tool.Biomolecular programming utilizes the reactions and information stored in biological molecules, such as proteins and nucleic acids, for computational purposes. DNA has proven itself an excellent candidate for building logic operating systems due to its highly predictable molecular behavior. In this work we designed and realized an XOR logic gate and an AND logic gate based on DNA strand displacement reactions. These logic gates utilize ssDNA as input and output signals. The XOR gate and the AND gate were used as building blocks for constructing a half adder logic circuit, which is a primary step in constructing a full adder, a basic arithmetic unit in computing. This work provides the field of DNA molecular programming with a potential universal arithmetic tool. Electronic supplementary information (ESI) available: Detailed descriptions of DNA logic gate design, materials and methods, and additional data analysis. See DOI: 10.1039/c5nr08497k

  11. Proposed inductive voltage adder based accelerator concepts for the second axis of DARHT

    SciTech Connect

    Smith, D.L.; Johnson, D.L.; Boyes, J.D.

    1997-06-01

    As participants in the Technology Options Study for the second axis of the Dual Axis Radiographic HydroTest (DARHT) facility located at Los Alamos National Laboratories, the authors have considered several accelerator concepts based on the Inductive Voltage Adder (IVA) technology that is being used successfully at Sandia on the SABRE and HERMES-III facilities. The challenging accelerator design requirements for the IVA approach include: {ge}12-MeV beam energy; {approximately}60-ns electrical pulse width; {le}40-kA electron beam current; {approximately}1-mm diameter e-beam; four pulses on the same axis or as close as possible to that axis; and an architecture that fits within the existing building envelope. To satisfy these requirements the IVA concepts take a modular approach. The basic idea is built upon a conservative design for eight ferromagnetically isolated 2-MV cavities that are driven by two 3 to 4-{Omega} water dielectric pulse forming lines (PFLs) synchronized with laser triggered gas switches. The 100-{Omega} vacuum magnetically insulated transmission line (MITL) would taper to a needle cathode that produces the electron beam(s). After considering many concepts the authors narrowed their study to the following options: (A) Four independent single pulse drivers powering four single pulse diodes; (B) Four series adders with interleaved cavities feeding a common MITL and diode; (C) Four stages of series PFLs, isolated from each other by triggered spark gap switches, with single-point feeds to a common adder, MITL, and diode; and (D) Isolated PFLs with multiple-feeds to a common adder using spark gap switches in combination with saturable magnetic cores to isolate the non-energized lines. The authors will discuss these options in greater detail identifying the challenges and risks associated with each.

  12. Venomous snakebites in southern Croatia.

    PubMed

    Luksić, Boris; Bradarić, Nikola; Prgomet, Sandra

    2006-03-01

    This retrospective study is based on the analysis of 542 snakebite envenomation cases in southern Croatia, which were treated in the University Hospital Split over the period of 21 years. The aim of this study was to determine the incidence of venomous snakebite in southern Croatia, epidemiological and clinical features of snakebite and treatment in the region. The mean annual snakebite incidence in southern Croatia was 5.2 per 100,000 inhabitants. The nose- horned viper (Vipera ammodytes) was responsible for most bites, only a small proportion being inflicted by the adder (Vipera berus). People of all ages were affected (1 - 82 year old), but the bites were more frequent in individuals older than 50 (46% of the cases) and in children and adolescents 19 year old and younger (27% of the cases). Most snakebite accidents happened in warm spring and summer months, the highest number occurring in May (22%). A majority of the victims were rural people engaged in agricultural activities. Bites on the upper limbs were more frequent (57%) than bites on the lower limbs (42%). With regard to envenomation severity, there were 15.1% minor, 40.5% mild, 26% moderate and 18% severe cases. Two victims died (0.4%). The antivenom produced by the Institute of Immunology in Zagreb was given to virtually all patients, and complications following its administration were rare. The antivenom was used more often than it was suggested by the symptoms present. PMID:16617597

  13. Low impedance z-pinch drivers without post-hole convolute current adders.

    SciTech Connect

    Savage, Mark Edward; Seidel, David Bruce; Mendel, Clifford Will, Jr.

    2009-09-01

    Present-day pulsed-power systems operating in the terawatt regime typically use post-hole convolute current adders to operate at sufficiently low impedance. These adders necessarily involve magnetic nulls that connect the positive and negative electrodes. The resultant loss of magnetic insulation results in electron losses in the vicinity of the nulls that can severely limit the efficiency of the delivery of the system's energy to a load. In this report, we describe an alternate transformer-based approach to obtaining low impedance. The transformer consists of coils whose windings are in parallel rather than in series, and does not suffer from the presence of magnetic nulls. By varying the pitch of the coils windings, the current multiplication ratio can be varied, leading to a more versatile driver. The coupling efficiency of the transformer, its behavior in the presence of electron flow, and its mechanical strength are issues that need to be addressed to evaluate the potential of transformer-based current multiplication as a viable alternative to conventional current adder technology.

  14. Memstor, memstance simulations via a versatile 4-port built with new adder and subtractor circuits

    NASA Astrophysics Data System (ADS)

    Minaei, Shahram; Cem Göknar, Izzet; Yıldız, Merih; Yuce, Erkan

    2015-06-01

    In this paper, novel voltage-mode (VM) n-channel metal-oxide semiconductor (NMOS) transistor-based analogue adder and subtractor circuits, which, respectively, perform V1+V2 and V1-V2 operations, are presented. The most important feature of the proposed circuits is their extremely simple structures containing only six NMOS transistors. Further, the presented adder and subtractor circuits have high input and low output impedances, resulting in easy cascadability. The post-layout simulations of the proposed circuits have been executed using TSMC 0.25 µm process parameters with ±1.25 V. The area of the suggested circuits is approximately 30 × 13 µm2. Moreover, the topology of a generalised mutator, a versatile 4-port built with an adder and a subtractor, which acts as an ordinary mutator when properly reduced to a 2-port, is offered. A table for simulating lossless inductance, memristor, meminductor, memcapacitor and other elements under suitable termination of the 4-port is given, and three of these elements' simulations with SPICE are also presented.

  15. A memory/adder model based on single C60 molecular transistors

    NASA Astrophysics Data System (ADS)

    Stadler, R.; Ami, S.; Forshaw, M.; Joachim, C.

    2001-09-01

    A recent proposal, in which 1-bit memory cells and simple logic gates such as NOT and NOR gates were based on C60 molecules in an electromechanical grid acting as transistors, is extended to larger architectures. In order to meet the requirements of standard digital circuit architectures, some modifications have to be made compared to the original model. For example, the number of transistors has to be increased from two to thirteen for a single NOR gate to guarantee balanced logical levels. In the scheme employed to achieve this in the current work, all two-input gates, namely OR, AND and XOR gates, can be easily constructed using the same concept. These gates are then used to design a 1-bit full-adder and a clocked D-latch, which are then combined with the earlier proposed 1-bit memory cell as the basic constituents of a memory/adder model. Clocked signal transmissions, corresponding to the read process of two 2-bit words from memory cells, their movement through registers and finally their addition and passing the output through another register, are simulated using the electrical circuit software SPICE. For the design of this memory/adder circuit, 464 single C60 transistors are used.

  16. Binary full adder, made of fusion gates, in a subexcitable Belousov-Zhabotinsky system

    NASA Astrophysics Data System (ADS)

    Adamatzky, Andrew

    2015-09-01

    In an excitable thin-layer Belousov-Zhabotinsky (BZ) medium a localized perturbation leads to the formation of omnidirectional target or spiral waves of excitation. A subexcitable BZ medium responds to asymmetric local perturbation by producing traveling localized excitation wave-fragments, distant relatives of dissipative solitons. The size and life span of an excitation wave-fragment depend on the illumination level of the medium. Under the right conditions the wave-fragments conserve their shape and velocity vectors for extended time periods. I interpret the wave-fragments as values of Boolean variables. When two or more wave-fragments collide they annihilate or merge into a new wave-fragment. States of the logic variables, represented by the wave-fragments, are changed in the result of the collision between the wave-fragments. Thus, a logical gate is implemented. Several theoretical designs and experimental laboratory implementations of Boolean logic gates have been proposed in the past but little has been done cascading the gates into binary arithmetical circuits. I propose a unique design of a binary one-bit full adder based on a fusion gate. A fusion gate is a two-input three-output logical device which calculates the conjunction of the input variables and the conjunction of one input variable with the negation of another input variable. The gate is made of three channels: two channels cross each other at an angle, a third channel starts at the junction. The channels contain a BZ medium. When two excitation wave-fragments, traveling towards each other along input channels, collide at the junction they merge into a single wave-front traveling along the third channel. If there is just one wave-front in the input channel, the front continues its propagation undisturbed. I make a one-bit full adder by cascading two fusion gates. I show how to cascade the adder blocks into a many-bit full adder. I evaluate the feasibility of my designs by simulating the evolution

  17. Binary full adder, made of fusion gates, in a subexcitable Belousov-Zhabotinsky system.

    PubMed

    Adamatzky, Andrew

    2015-09-01

    In an excitable thin-layer Belousov-Zhabotinsky (BZ) medium a localized perturbation leads to the formation of omnidirectional target or spiral waves of excitation. A subexcitable BZ medium responds to asymmetric local perturbation by producing traveling localized excitation wave-fragments, distant relatives of dissipative solitons. The size and life span of an excitation wave-fragment depend on the illumination level of the medium. Under the right conditions the wave-fragments conserve their shape and velocity vectors for extended time periods. I interpret the wave-fragments as values of Boolean variables. When two or more wave-fragments collide they annihilate or merge into a new wave-fragment. States of the logic variables, represented by the wave-fragments, are changed in the result of the collision between the wave-fragments. Thus, a logical gate is implemented. Several theoretical designs and experimental laboratory implementations of Boolean logic gates have been proposed in the past but little has been done cascading the gates into binary arithmetical circuits. I propose a unique design of a binary one-bit full adder based on a fusion gate. A fusion gate is a two-input three-output logical device which calculates the conjunction of the input variables and the conjunction of one input variable with the negation of another input variable. The gate is made of three channels: two channels cross each other at an angle, a third channel starts at the junction. The channels contain a BZ medium. When two excitation wave-fragments, traveling towards each other along input channels, collide at the junction they merge into a single wave-front traveling along the third channel. If there is just one wave-front in the input channel, the front continues its propagation undisturbed. I make a one-bit full adder by cascading two fusion gates. I show how to cascade the adder blocks into a many-bit full adder. I evaluate the feasibility of my designs by simulating the evolution

  18. Reproductive ecology of Vipera latastei, in the Iberian Peninsula: implications for the conservation of a Mediterranean viper.

    PubMed

    Pleguezuelos, Juan Manuel; Santos, Xavier; Brito, José Carlos; Parellada, Xavier; Llorente, Gustavo Adolfo; Fahd, Soumia

    2007-01-01

    Eurosiberian vipers have been considered model organisms, and studies on their reproductive ecology have afforded much of the current knowledge concerning viviparity in snakes. However, such studies are biased towards northern species and there is little information on Mediterranean species and/or populations. The reproductive ecology of Vipera latastei in the Iberian Peninsula was studied by analysing a large sample of specimens from collections, to better understand the conservation status of this Mediterranean viper. Males and females matured at small and similar body sizes (240 and 265 mm snout-vent length, respectively) and reproductive cycles in both sexes were seasonal. Spermatogenesis peaked in August, vitellogenesis developed in spring and the timing of the mating period was puzzling, with populations mating in autumn, spring, or in both seasons. The most striking finding was that adult females reproduced triennially on average. Lataste's viper is currently in continuous decline in the IP, and most of its populations are isolated in Mediterranean mountains. We hypothesize that prey scarcity and the brevity of the activity period in mountain habitats diminishes the ability of vipers to recover over the short term the energy expended in reproduction. The species needs 2 years for the acquisition and storage of energy ("capital breeder"), and a third year for the expenditure of this energy (in vitellogenesis and embryogenesis), a year during which females feed consistently ("income breeder"). Thus, this viper combines both strategies to supply the reproductive energy cost. Current decline in population and distribution, together with a poor capacity to renew populations, renders Lataste's viper vulnerable to environmental stochasticity. PMID:17161594

  19. Design and code validation of the Jupiter inductive voltage adder (IVA) PRS driver

    SciTech Connect

    Mazarakis, M.G.; Poukey, J.W.; Mendel, C.W.

    1995-07-01

    The proposed Jupiter accelerator is a {approximately} 10-MV, 500-TW system capable of delivering 15-MJ kinetic energy to an imploding plasma radiation source (PRS). The accelerator is based on Hermes-III technology and contains 30 identical inductive voltage adder modules connected in parallel. The modules drive a common circular convolute electrode system in the center of which is located an imploding foil. The relatively high voltage of 8--10 MV is required to compensate for the voltage differential generated across the load due primarily to the fast increase in current (L di/dt) and to lesser extent to the increasing inductance(I dL/dt) and resistive component of the imploding foil. Here we examine the power flow through the device and, in particular, through the voltage adder and long MITL. Analytical models, such as pressure balance and parapotential flow, as well as circuit and PIC codes, were utilized. A new version of the TWOQUICK PIC code, which includes an imploding, cylindrical foil as load, was utilized to compare the power flow calculations done with SCREAMER and TRIFL. The agreement is very satisfactory and adds confidence to the Jupiter design. In addition, an experimental validation of the design is under way this year (FY95) with Hermes III. Long extension MITLs are connected at the end of the voltage adder with inductive and diode loads to benchmark the above design codes. In this paper we outline the accelerator`s conceptual design with emphasis on the power flow and coupling to the inductive load and include preliminary results of Hermes-III experimental design validation.

  20. The mathematics of a quantum Hamiltonian computing half adder Boolean logic gate.

    PubMed

    Dridi, G; Julien, R; Hliwa, M; Joachim, C

    2015-08-28

    The mathematics behind the quantum Hamiltonian computing (QHC) approach of designing Boolean logic gates with a quantum system are given. Using the quantum eigenvalue repulsion effect, the QHC AND, NAND, OR, NOR, XOR, and NXOR Hamiltonian Boolean matrices are constructed. This is applied to the construction of a QHC half adder Hamiltonian matrix requiring only six quantum states to fullfil a half Boolean logical truth table. The QHC design rules open a nano-architectronic way of constructing Boolean logic gates inside a single molecule or atom by atom at the surface of a passivated semi-conductor. PMID:26234709

  1. The mathematics of a quantum Hamiltonian computing half adder Boolean logic gate

    NASA Astrophysics Data System (ADS)

    Dridi, G.; Julien, R.; Hliwa, M.; Joachim, C.

    2015-08-01

    The mathematics behind the quantum Hamiltonian computing (QHC) approach of designing Boolean logic gates with a quantum system are given. Using the quantum eigenvalue repulsion effect, the QHC AND, NAND, OR, NOR, XOR, and NXOR Hamiltonian Boolean matrices are constructed. This is applied to the construction of a QHC half adder Hamiltonian matrix requiring only six quantum states to fullfil a half Boolean logical truth table. The QHC design rules open a nano-architectronic way of constructing Boolean logic gates inside a single molecule or atom by atom at the surface of a passivated semi-conductor.

  2. The influence of body condition on 17-beta estradiol levels in relation to vitellogenesis in female Vipera aspis (Reptilia, Viperidae).

    PubMed

    Bonnet, X; Naulleau, G; Mauget, R

    1994-03-01

    Seventy-six wild Vipera aspis females were caught over 3 years and placed in outdoor enclosures; 39 reproduced and 37 did not. Almost all the reproductive females had a body condition index (BCI) greater than 0.70 when vitellogenesis began. Monthly blood samples were taken by cardiac puncture. The main plasma parameters of vitellogenesis were measured by spectrophotometry: total plasma calcium, phosphorus, phospholipids, cholesterol, triglycerides, proteins, and albumin. Plasma 17-beta estradiol levels were determined by RIA. Vitellogenesis started soon after hibernation in reproductive females with very high 17-beta estradiol concentrations (average of 4.00 ng/ml) and there was a marked mobilization of maternal reserves (fat bodies, liver, and vertebral bone) associated with very high values of plasma calcium, phosphorus, phospholipids, cholesterol, triglycerides, and proteins. The kinetics of the main plasma components were described throughout the vitellogenesis period (from March to early June), when all plasma parameters differed markedly between reproductive and nonreproductive females. After ovulation, the differences between the two groups of females disappeared except in the case of albumin, which remained at a very low level in reproductive females for 6 months. All nonreproductive females had low 17-beta estradiol plasma levels during vitellogenesis (average of 0.08 ng/ml) and there was no suggestion of mobilization of maternal reserves. After vitellogenesis plasma concentrations of estradiol were low in reproductive (an average of 0.08 ng/ml) and in nonreproductive animals (0.06 ng/ml). Five nonreproductive females kept in the laboratory were estrogenized by 17-beta estradiol silastic implants. The 17-beta estradiol concentrations were close to those measured in reproductive females during vitellogenesis. Maternal reserves were mobilized, with almost all metabolic parameters exhibiting the vitellogenic pattern. When the silastic implants were removed

  3. An ambusher's arsenal: chemical crypsis in the puff adder (Bitis arietans).

    PubMed

    Miller, Ashadee Kay; Maritz, Bryan; McKay, Shannon; Glaudas, Xavier; Alexander, Graham J

    2015-12-22

    Ambush foragers use a hunting strategy that places them at risk of predation by both visual and olfaction-oriented predators. Resulting selective pressures have driven the evolution of impressive visual crypsis in many ambushing species, and may have led to the development of chemical crypsis. However, unlike for visual crypsis, few studies have attempted to demonstrate chemical crypsis. Field observations of puff adders (Bitis arietans) going undetected by several scent-orientated predator and prey species led us to investigate chemical crypsis in this ambushing species. We trained dogs (Canis familiaris) and meerkats (Suricata suricatta) to test whether a canid and a herpestid predator could detect B. arietans using olfaction. We also tested for chemical crypsis in five species of active foraging snakes, predicted to be easily detectable. Dogs and meerkats unambiguously indicated active foraging species, but failed to correctly indicate puff adder, confirming that B. arietans employs chemical crypsis. This is the first demonstration of chemical crypsis anti-predatory behaviour, though the phenomenon may be widespread among ambushers, especially those that experience high mortality rates owing to predation. Our study provides additional evidence for the existence of an ongoing chemically mediated arms race between predator and prey species. PMID:26674950

  4. Viper bites: treat or ignore? Review of a series of 99 patients bitten by Vipera aspis in an alpine Swiss area.

    PubMed

    Petite, Jacques

    2005-10-15

    In a well defined alpine area of Switzerland (Valais, about 300000 inhabitants, tourists included) we studied retrospectively over 32 years, 99 patients bitten by vipers (Vipera aspis, the likely unique species in this area). The annual incidence was estimated at 3/100,000, as in other European countries. The mortality was 0% for the adults. The patients, 72 adults and 17 children (13 years and less), were classified in four groups: grade 0 no envenomation (8%), grade 1 minimal (42%), grade 2 moderate (40%), and grade 3 severe envenomation (10%). The 10 patients of grade 3 showed impressive clinical signs and blood abnormalities, as exemplified by our three most severe cases. Only patients of grade 3 must be treated with antivenom and other intensive treatments, but all patients, even grade 1, especially small children, must be observed for several hours. PMID:16380847

  5. MOSFET-based high voltage double square-wave pulse generator with an inductive adder configuration

    NASA Astrophysics Data System (ADS)

    Zhao, Xin; Zhang, Qiaogen; Long, Jinghua; Lei, Yunfei; Liu, Jinyuan

    2015-09-01

    This paper presents a fast MOSFET-based solid-state pulse generator for high voltage double square-wave pulses. The generator consists mainly of an inductive adder system stacked of 20 solid-state modules. Each of the modules has 18 power MOSFETs in parallel, which are triggered by individual drive circuits; these drive circuits themselves are synchronously triggered by a signal from avalanche transistors. Our experiments demonstrate that the output pulses with amplitude of 8.1 kV and peak current of about 405 A are available at a load impedance of 20 Ω. The pulse has a double square-wave form with a rise and fall time of 40 ns and 26 ns, respectively and bottom flatness better than 12%. The interval time of the double square-wave pulses can be adjustable by varying the interval time of the trigger pulses.

  6. Fast Discrete Fourier Transform Computations Using the Reduced Adder Graph Technique

    NASA Astrophysics Data System (ADS)

    Meyer-Bäse, Uwe; Natarajan, Hariharan; Dempster, Andrew G.

    2007-12-01

    It has recently been shown that thse[InlineEquation not available: see fulltext.]-dimensional reduced adder graph (RAG-[InlineEquation not available: see fulltext.]) technique is beneficial for many DSP applications such as for FIR and IIR filters, where multipliers can be grouped in multiplier blocks. This paper highlights the importance of DFT and FFT as DSP objects and also explores how the RAG-[InlineEquation not available: see fulltext.] technique can be applied to these algorithms. This RAG-[InlineEquation not available: see fulltext.] DFT will be shown to be of low complexity and possess an attractively regular VLSI data flow when implemented with the Rader DFT algorithm or the Bluestein chirp-[InlineEquation not available: see fulltext.] algorithm. ASIC synthesis data are provided and demonstrate the low complexity and high speed of the design when compared to other alternatives.

  7. Toward defect guard-banding of EUV exposures by full chip optical wafer inspection of EUV mask defect adders

    NASA Astrophysics Data System (ADS)

    Halle, Scott D.; Meli, Luciana; Delancey, Robert; Vemareddy, Kaushik; Crispo, Gary; Bonam, Ravi; Burkhardt, Martin; Corliss, Daniel

    2015-03-01

    The detection of EUV mask adder defects has been investigated with an optical wafer defect inspection system employing a methodology termed Die-to-"golden" Virtual Reference Die (D2VRD). Both opaque and clear type mask absorber programmed defects were inspected and characterized over a range of defect sizes, down to (4x mask) 40 nm. The D2VRD inspection system was capable of identifying the corresponding wafer print defects down to the limit of the defect printability threshold at approximately 30 nm (1x wafer). The efficacy of the D2VRD scheme on full chip wafer inspection to suppress random process defects and identify real mask defects is demonstrated. Using defect repeater analysis and patch image classification of both the reference die and the scanned die enables the unambiguous identification of mask adder defects.

  8. Development of an optical parallel logic device and a half-adder circuit for digital optical processing

    NASA Technical Reports Server (NTRS)

    Athale, R. A.; Lee, S. H.

    1978-01-01

    The paper describes the fabrication and operation of an optical parallel logic (OPAL) device which performs Boolean algebraic operations on binary images. Several logic operations on two input binary images were demonstrated using an 8 x 8 device with a CdS photoconductor and a twisted nematic liquid crystal. Two such OPAL devices can be interconnected to form a half-adder circuit which is one of the essential components of a CPU in a digital signal processor.

  9. Resembling a viper: implications of mimicry for conservation of the endangered smooth snake.

    PubMed

    Valkonen, Janne K; Mappes, Johanna

    2014-12-01

    The phenomenon of Batesian mimicry, where a palatable animal gains protection against predation by resembling an unpalatable model, has been a core interest of evolutionary biologists for 150 years. An extensive range of studies has focused on revealing mechanistic aspects of mimicry (shared education and generalization of predators) and the evolutionary dynamics of mimicry systems (co-operation vs. conflict) and revealed that protective mimicry is widespread and is important for individual fitness. However, according to our knowledge, there are no case studies where mimicry theories have been applied to conservation of mimetic species. Theoretically, mimicry affects, for example, frequency dependency of predator avoidance learning and human induced mortality. We examined the case of the protected, endangered, nonvenomous smooth snake (Coronella austriaca) that mimics the nonprotected venomous adder (Vipera berus), both of which occur in the Åland archipelago, Finland. To quantify the added predation risk on smooth snakes caused by the rarity of vipers, we calculated risk estimates from experimental data. Resemblance of vipers enhances survival of smooth snakes against bird predation because many predators avoid touching venomous vipers. Mimetic resemblance is however disadvantageous against human predators, who kill venomous vipers and accidentally kill endangered, protected smooth snakes. We found that the effective population size of the adders in Åland is very low relative to its smooth snake mimic (28.93 and 41.35, respectively).Because Batesian mimicry is advantageous for the mimic only if model species exist in sufficiently high numbers, it is likely that the conservation program for smooth snakes will fail if adders continue to be destroyed. Understanding the population consequences of mimetic species may be crucial to the success of endangered species conservation. We suggest that when a Batesian mimic requires protection, conservation planners should

  10. A new linear inductive voltage adder driver for the Saturn Accelerator

    SciTech Connect

    Mazarakis, M.G.; Spielman, R.B.; Struve, K.W.; Long, F.W.

    2000-08-09

    Saturn is a dual-purpose accelerator. It can be operated as a large-area flash x-ray source for simulation testing or as a Z-pinch driver especially for K-line x-ray production. In the first mode, the accelerator is fitted with three concentric-ring 2-MV electron diodes, while in the Z-pinch mode the current of all the modules is combined via a post-hole convolute arrangement and driven through a cylindrical array of very fine wires. We present here a point design for a new Saturn class driver based on a number of linear inductive voltage adders connected in parallel. A technology recently implemented at the Institute of High Current Electronics in Tomsk (Russia) is being utilized. In the present design we eliminate Marx generators and pulse-forming networks. Each inductive voltage adder cavity is directly fed by a number of fast 100-kV small-size capacitors arranged in a circular array around each accelerating gap. The number of capacitors connected in parallel to each cavity defines the total maximum current. By selecting low inductance switches, voltage pulses as short as 30-50-ns FWHM can be directly achieved. The voltage of each stage is low (100-200 kv). Many stages are required to achieve multi-megavolt accelerator output. However, since the length of each stage is very short (4-10 cm), accelerating gradients of higher than 1 MV/m can easily be obtained. The proposed new driver will be capable of delivering pulses of 15-MA, 36-TW, 1.2-MJ to the diode load, with a peak voltage of {minus}2.2 MV and FWHM of 40-ns. And although its performance will exceed the presently utilized driver, its size and cost could be much smaller ({approximately}1/3). In addition, no liquid dielectrics like oil or deionized water will be required. Even elimination of ferromagnetic material (by using air-core cavities) is a possibility.

  11. Deep evolutionary lineages in a Western Mediterranean snake (Vipera latastei/monticola group) and high genetic structuring in Southern Iberian populations.

    PubMed

    Velo-Antón, G; Godinho, R; Harris, D J; Santos, X; Martínez-Freiria, F; Fahd, S; Larbes, S; Pleguezuelos, J M; Brito, J C

    2012-12-01

    Phylogeographic studies during the last decade confirmed an internal complexity of the Iberian Peninsula and northern Maghreb as refugial areas during the Miocene to Pleistocene period. Species with low vagility that experienced the complex climatic and palaeogeographic processes occurred in the Western Mediterranean Basin are excellent candidates to study the extent of lineage diversification in this region. We applied phylogenetic analyses based on mitochondrial data to infer the evolutionary history of Vipera latastei/monticola and identify the major biogeographic events structuring the genetic diversity within this group. We obtained a well-resolved phylogeny, with four highly divergent lineages (one African and three Iberian) that originated in the Tertiary. Coalescence-based estimations suggest that the differentiation of the four major lineages in V. latastei/monticola corresponds to the Messinian salinity crisis and the reopening of the Strait of Gibraltar during the Miocene. Subsequent Pliocene and Pleistocene climatic oscillations continued to isolate both Iberian and Maghrebian populations and led to a high genetic structuring in this group, particularly in Southern Iberia, a complex palaeogeographic and topographic region with high endemism levels. This study does not support the current taxonomy of the group, thus suggesting that an integrative evaluation of Iberian and African populations is needed to resolve its systematics. PMID:22982758

  12. SplAdder: identification, quantification and testing of alternative splicing events from RNA-Seq data

    PubMed Central

    Kahles, André; Ong, Cheng Soon; Zhong, Yi; Rätsch, Gunnar

    2016-01-01

    Motivation: Understanding the occurrence and regulation of alternative splicing (AS) is a key task towards explaining the regulatory processes that shape the complex transcriptomes of higher eukaryotes. With the advent of high-throughput sequencing of RNA (RNA-Seq), the diversity of AS transcripts could be measured at an unprecedented depth. Although the catalog of known AS events has grown ever since, novel transcripts are commonly observed when working with less well annotated organisms, in the context of disease, or within large populations. Whereas an identification of complete transcripts is technically challenging and computationally expensive, focusing on single splicing events as a proxy for transcriptome characteristics is fruitful and sufficient for a wide range of analyses. Results: We present SplAdder, an alternative splicing toolbox, that takes RNA-Seq alignments and an annotation file as input to (i) augment the annotation based on RNA-Seq evidence, (ii) identify alternative splicing events present in the augmented annotation graph, (iii) quantify and confirm these events based on the RNA-Seq data and (iv) test for significant quantitative differences between samples. Thereby, our main focus lies on performance, accuracy and usability. Availability: Source code and documentation are available for download at http://github.com/ratschlab/spladder. Example data, introductory information and a small tutorial are accessible via http://bioweb.me/spladder. Contacts: andre.kahles@ratschlab.org or gunnar.ratsch@ratschlab.org Supplementary information: Supplementary data are available at Bioinformatics online. PMID:26873928

  13. All-Optical Half-Adder Using All-Optical XOR and AND Gates for Optical Generation of "Sum" and "Carry"

    NASA Astrophysics Data System (ADS)

    Menezes, J. W. M.; Fraga, W. B.; Ferreira, A. C.; Guimarães, G. F.; Filho, A. F. G. F.; Sobrinho, C. S.; Sombra, A. S. B.

    2010-07-01

    In this article, a numerical simulation study using the symmetric planar three-core non-linear directional coupler, operating with a short light pulse (2 ps), for the implementation of an all-optical half-adder is presented. The half-adder is the key building block for many digital processing functions such as shift register, binary counter, and serial parallel data converters. Optical couplers are an important component for application in optical fiber telecommunication systems and all integrated optical circuits because of very high switching speeds (as high as the femto-second range). In this numerical simulation, the symmetric planar three-core non-linear directional coupler presents a planar symmetrical structure with three cores in a parallel equidistant arrangement, three logical inputs (CP, A, and B), and two output logic functions (C and S). The CP(ΔΦ) input is a control pulse with a phase difference ΔΦ = Δθπ (0 ≤ Δθ ≤ 2) between inputs A and B (logical inputs of the half-adder) and one amplitude discriminator circuit. The half-adder uses two output logic functions of Sum(S) and Carry(C), which can be demonstrated by using XOR and AND gates, respectively. For the half-adder, the phase [ΔΦMIN, ΔΦMAX] intervals are studied, allowing the operation of the device as a half-adder. For the selected range of CP(ΔΦBETTER), the extinction ratio was studied, the compression factors for both Sum(S) and Carry(C) outputs of the symmetric planar three-core non-linear directional coupler.

  14. Towards constructing one-bit binary adder in excitable chemical medium

    NASA Astrophysics Data System (ADS)

    Lacy Costello, Ben De; Adamatzky, Andy; Jahan, Ishrat; Zhang, Liang

    2011-03-01

    The light-sensitive modification (ruthenium catalysed) of the Belousov-Zhabotinsky reaction exhibits various excitability regimes depending on the level of illumination. Within a narrow range of applied illumination levels the medium is in a sub-excitable state. When in this state an asymmetric perturbation of the medium leads to formation of a travelling localized excitation (wave-fragment) which moves along a predetermined trajectory, ideally preserving its shape and velocity over an extended time period. Collision-based computing can be implemented with these wave-fragments whereby values of Boolean variables are represented as the presence/absence of a wave-fragment at specific sites. When two wave-fragments collide they either annihilate, or form new wave-fragments. The trajectories of the wave-fragments after the collision represent the result of a computation, e.g. construction of a simple logical gate. However, wave-fragments in sub-excitable chemical media are difficult to control. Therefore, we adopted a hybrid procedure in order to construct collision-based logical gates. We used channels of low light intensity projected onto the excitable media in order to subtly tune and stabilise the propagating wave-fragments allowing them to collide at the junctions between channels. Using this methodology we were able to implement both in theoretical models (using the Oregonator) and in experiment two interaction-based logical gates and assemble the gates into a basic one-bit binary adder. We present the first ever experimental approach towards constructing arithmetic circuits in spatially-extended excitable chemical systems where light is used to impart functionality.

  15. Snake venom toxin from Vipera lebetina turanica sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins.

    PubMed

    Park, Mi Hee; Jo, Miran; Won, Dohee; Song, Ho Sueb; Song, Min Jong; Hong, Jin Tae

    2012-12-01

    We investigated whether snake venom toxin (SVT) from Vipera lebetina turanica enhances the apoptosis ability of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in cancer cells. TRAIL inhibited HCT116 cell growth in a dose-dependent manner; however, this reduction did not occur in TRAIL resistant HT-29, A549 and HepG2 cells with an even higher dose of TRAIL. SVT, but not TRAIL enhanced expression of cell death receptor (DR) in TRAIL resistant cancer cells in a dose-dependent manner. A combination of SVT with TRAIL significantly inhibited cell growth of TRAIL resistant HT-29, A549 and HepG2 cells. Consistent with cell growth inhibition, the expression of TRAIL receptors; DR4 and DR5 was significantly increased as well as apoptosis related proteins such as cleaved caspase-3, -8, -9 and Bax. However, the expression of survival proteins (e.g., cFLIP, survivin, XIAP and Bcl2) was suppressed by the combination treatment of SVT and TRAIL. Depletion of DR4 or DR5 by small interfering RNA significantly reversed the cell growth inhibitory and apoptosis blocking effects of SVT in HCT116 and HT-29 cells. Pretreatment with the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the reactive oxygen species (ROS) scavenger N-acetylcysteine reduced the SVT and TRAIL-induced upregulation of DR4 and DR5 expression, expression of the apoptosis related protein such as caspase-3 and-9, as well as cell growth inhibitory effects. The collective results suggest that SVT facilitates TRAIL-induced apoptosis in cancer cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS/JNK pathway signals. PMID:23007278

  16. A pulsed-power generator merging inductive voltage and current adders and its switch trigger application example

    NASA Astrophysics Data System (ADS)

    Li, Lee; Yafeng, Ge; Heqin, Zhong; Bin, Yu; Longjun, Xie

    2013-07-01

    A pulsed-power generator using inductive adder technology is proposed for the case of a discharge gap. The merit of this generator is to merge the pulsed-voltage and pulsed-current adders via the dual secondary windings with special circuit. For the nonlinear impedance in any discharge gap, the standalone voltage-pulse and current-pulse can be outputted successively by this generator. The proposed generator is especially useful for the common resolution of implementing pulse discharge at less cost. As an application example, a compact trigger prototype was developed to compatibly use in the gas-insulated and vacuum switches. Experiments achieved good results that the triggered switches showed stable performance and long life. If the basic circuit of this proposed generator is regarded as a pulsed-generating unit, a certain number of such units connected in parallel can be expected to form a general device with generating greater breakdown-voltage and sustained-current pulses for discharge gaps.

  17. Ion diode performance on a positive polarity inductive voltage adder with layered magnetically insulated transmission line flow

    NASA Astrophysics Data System (ADS)

    Hinshelwood, D. D.; Ottinger, P. F.; Schumer, J. W.; Allen, R. J.; Apruzese, J. P.; Commisso, R. J.; Cooperstein, G.; Jackson, S. L.; Murphy, D. P.; Phipps, D.; Swanekamp, S. B.; Weber, B. V.; Young, F. C.

    2011-05-01

    A pinch-reflex ion diode is fielded on the pulsed-power machine Mercury (R. J. Allen, et al., 15th IEEE Intl. Pulsed Power Conf., Monterey, CA, 2005, p. 339), which has an inductive voltage adder (IVA) architecture and a magnetically insulated transmission line (MITL). Mercury is operated in positive polarity resulting in layered MITL flow as emitted electrons are born at a different potential in each of the adder cavities. The usual method for estimating the voltage by measuring the bound current in the cathode and anode of the MITL is not accurate with layered flow, and the interaction of the MITL flow with a pinched-beam ion diode load has not been studied previously. Other methods for determining the diode voltage are applied, ion diode performance is experimentally characterized and evaluated, and circuit and particle-in-cell (PIC) simulations are performed. Results indicate that the ion diode couples efficiently to the machine operating at a diode voltage of about 3.5 MV and a total current of about 325 kA, with an ion current of about 70 kA of which about 60 kA is proton current. It is also found that the layered flow impedance of the MITL is about half the vacuum impedance.

  18. Ion diode performance on a positive polarity inductive voltage adder with layered magnetically insulated transmission line flow

    SciTech Connect

    Hinshelwood, D. D.; Schumer, J. W.; Allen, R. J.; Commisso, R. J.; Jackson, S. L.; Murphy, D. P.; Phipps, D.; Swanekamp, S. B.; Weber, B. V.; Ottinger, P. F.; Apruzese, J. P.; Cooperstein, G.; Young, F. C.

    2011-05-15

    A pinch-reflex ion diode is fielded on the pulsed-power machine Mercury (R. J. Allen, et al., 15th IEEE Intl. Pulsed Power Conf., Monterey, CA, 2005, p. 339), which has an inductive voltage adder (IVA) architecture and a magnetically insulated transmission line (MITL). Mercury is operated in positive polarity resulting in layered MITL flow as emitted electrons are born at a different potential in each of the adder cavities. The usual method for estimating the voltage by measuring the bound current in the cathode and anode of the MITL is not accurate with layered flow, and the interaction of the MITL flow with a pinched-beam ion diode load has not been studied previously. Other methods for determining the diode voltage are applied, ion diode performance is experimentally characterized and evaluated, and circuit and particle-in-cell (PIC) simulations are performed. Results indicate that the ion diode couples efficiently to the machine operating at a diode voltage of about 3.5 MV and a total current of about 325 kA, with an ion current of about 70 kA of which about 60 kA is proton current. It is also found that the layered flow impedance of the MITL is about half the vacuum impedance.

  19. Hemorrhagin VaH4, a covalent heterodimeric P-III metalloproteinase from Vipera ammodytes ammodytes with a potential antitumour activity.

    PubMed

    Leonardi, Adrijana; Sajevic, Tamara; Kovačič, Lidija; Pungerčar, Jože; Lang Balija, Maja; Halassy, Beata; Trampuš Bakija, Alenka; Križaj, Igor

    2014-01-01

    In the envenomation caused by a bite of Vipera ammodytes ammodytes, the most venomous snake in Europe, hemorrhage is usually the most severe consequence in man. Identifying and understanding the hemorrhagic components of its venom is therefore particularly important in optimizing medical treatment of patients. We describe a novel high molecular mass hemorrhagin, VaH4. The isolated molecule is a covalent dimer of two homologous subunits, VaH4-A and VaH4-B. Complete structural characterization of A and partial characterization of B revealed that both belong to the P-III class of snake venom metalloproteinases (SVMPs), comprising a metalloproteinase, a disintegrin-like domain and a cysteine-rich domain. However, neither VaH4-A nor VaH4-B possess the Cys174 involved in the inter-subunit disulphide bond of P-III SVMPs. A three-dimensional model of the VaH4 dimer suggests that Cys132 serves this function. This implies that dimers in the P-III class of SVMPs can be formed either between their Cys132 or Cys174 residues. The proteolytic activity and stability of VaH4 depend on Zn²⁺ and Ca²⁺ ions and the presence of glycosaminoglycans, which indicates physiological interaction of VaH4 with the latter element of the extracellular matrix (ECM). The molecular mass of VaH4, determined by MALDI/TOF mass spectrometry, is 110.2 kDa. N-deglycosylation reduced the mass of each monomer by 8.7 kDa. The two possible N-glycosylation sites in VaH4-A are located at completely different positions from those in homodimeric P-IIIc VaH3 from the same venom, however, without any evident functional implications. The hemorrhagic activity of this slightly acidic SVMP is ascribed to its hydrolysis of components of the ECM, particularly fibronectin and nidogen, and of some blood coagulation proteins, in particular the α-chain of fibrinogen. VaH4 is also significant medically as we found it cytotoxic against cancer cells and due to its substantial sequence similarity to ADAM/ADAMTS family of

  20. A tight-binding study of a 1-bit half-adder based on diode logic integrated inside a single molecule

    NASA Astrophysics Data System (ADS)

    Stadler, R.; Ami, S.; Forshaw, M.; Joachim, C.

    2003-07-01

    The design of a 1-bit half-adder diode logic circuit inside a single molecule is investigated, with the chemical groups for diodes and wires bonded together to form the molecular circuit. With a circuit working in the ballistic transport regime, interference effects between the different electron paths in the circuit make the optimization of the circuit's logic function very delicate. In the tunnelling regime, these effects are partly suppressed. But the exponential decay of the current with the wire length imposes additional constraints for circuit design. A programmable gate logic array-like architecture would be expected be more useful for the design of a 1-bit adder in the ballistic regime due to the regularity of the circuit lattice, which might reduce interferences. On the other hand, a dedicated design which minimizes the amount of wiring might be the better choice for the tunnelling regime. However, we find that the logic output of classical diode logic circuits cannot be reproduced in either regime because Kirchhoff-like circuit rules do not apply. Furthermore, the geometry dependence of electron transmission in both regimes would make it impractical to build up logical functions like the SUM of an adder from simple OR- and AND-gates, even if the output pattern of these gates could be perfectly reproduced.

  1. Quantum dot ternary-valued full-adder: Logic synthesis by a multiobjective design optimization based on a genetic algorithm

    SciTech Connect

    Klymenko, M. V.; Remacle, F.

    2014-10-28

    A methodology is proposed for designing a low-energy consuming ternary-valued full adder based on a quantum dot (QD) electrostatically coupled with a single electron transistor operating as a charge sensor. The methodology is based on design optimization: the values of the physical parameters of the system required for implementing the logic operations are optimized using a multiobjective genetic algorithm. The searching space is determined by elements of the capacitance matrix describing the electrostatic couplings in the entire device. The objective functions are defined as the maximal absolute error over actual device logic outputs relative to the ideal truth tables for the sum and the carry-out in base 3. The logic units are implemented on the same device: a single dual-gate quantum dot and a charge sensor. Their physical parameters are optimized to compute either the sum or the carry out outputs and are compatible with current experimental capabilities. The outputs are encoded in the value of the electric current passing through the charge sensor, while the logic inputs are supplied by the voltage levels on the two gate electrodes attached to the QD. The complex logic ternary operations are directly implemented on an extremely simple device, characterized by small sizes and low-energy consumption compared to devices based on switching single-electron transistors. The design methodology is general and provides a rational approach for realizing non-switching logic operations on QD devices.

  2. Fast Differential Adder

    NASA Technical Reports Server (NTRS)

    Arditti, Mort A.; Silva, Rosemary

    1993-01-01

    Differential adding circuit (or, equivalently, subtracting circuit) faster and consumes less power because it contains only one differential amplifier. Suitable for use in high-frequency-switching, high power-regulating circuit.

  3. Study of the Performance of an All-Optical Half-Adder Based on Three-Core Non-Linear Directional Fiber Coupler Under Delayed and Instantaneous Non-Linear Kerr Responses

    NASA Astrophysics Data System (ADS)

    Menezes, J. W. M.; Fraga, W. B.; Lima, F. T.; Guimarães, G. F.; Ferreira, A. C.; Lyra, M. L.; Sombra, A. S. B.

    2011-06-01

    Recently, much attention has been given to the influence of the relaxation process of the non-linear response, because the usual assumption of instantaneous non-linear response fails for ultra-short pulses, and additional contributions coming from non-linear dispersion and delayed non-linearity have to be taken into account. This article presents a numerical analysis of the symmetric planar and asymmetric planar three-core non-linear directional fiber couplers operating with a soliton pulse, where effects of both delayed and instantaneous non-linear Kerr responses are analyzed for implementation of an all-optical half-adder. To implement this all-optical half-adder, eight configurations were analyzed for the non-linear directional fiber coupler, with two symmetric and six asymmetric configurations. The half-adder is the key building block for many digital processing functions, such as shift register, binary counter, and serial parallel data converters. The optical coupler is an important component for applications in optical-fiber telecommunication systems and all integrated optical circuit because of its very high switching speeds. In this numerical simulation, the symmetric/asymmetric planar presents a structure with three cores in a parallel equidistant arrangement, three logical inputs, and two output energy. To prove the effectiveness of the theoretical model for generation of the all-optical half-adder, the best phase to be applied to the control pulse was sought, and a study was done of the extinction ratio level as a function of the Δ > parameter, the normalized time duration, and the Sum and Carry outputs of the (symmetric planar/asymmetric planar) non-linear directional fiber coupler. In this article, the interest is in transmission characteristics, extinction ratio level, normalized time duration, and pulse evolution along the non-linear directional fiber coupler. To compare the performance of the all-optical half-adders, the figure of merit of the

  4. Experiments investigating the generation and transport of 10--12 MeV, 30-kA, mm-size electron beams with linear inductive voltage adders

    SciTech Connect

    Mazarakis, M.G.; Poukey, J.W.; Maenchen, J.E.

    1997-06-01

    The authors present the design, analysis, and results of the high-brightness electron beam experiments currently under investigation at Sandia National Laboratories. The anticipated beam parameters are the following: 8--12 MeV, 35--50 kA, 30--60 ns FWHM, and 0.5-mm rms beam radius. The accelerators utilized are SABRE and HERMES III. Both are linear inductive voltage adders modified to higher impedance and fitted with magnetically immersed foil less electron diodes. In the strong 20--50 Tesla solenoidal magnetic field of the diode, mm-size electron beams are generated and propagated to a beam stop. The electron beam is field emitted from mm-diameter needle-shaped cathode electrode and is contained in a similar size envelop by the strong magnetic field. These extremely space charge dominated beams provide the opportunity to study beam dynamics and possible instabilities in a unique parameter space. The SABRE experiments are already completed and have produced 30-kA, 1.5-mm FWHM electron beams, while the HERMES-III experiments are on-going.

  5. Nowhere to Go but Up: Impacts of Climate Change on Demographics of a Short-Range Endemic (Crotalus willardi obscurus) in the Sky-Islands of Southwestern North America.

    PubMed

    Davis, Mark A; Douglas, Marlis R; Webb, Colleen T; Collyer, Michael L; Holycross, Andrew T; Painter, Charles W; Kamees, Larry K; Douglas, Michael E

    2015-01-01

    Biodiversity elements with narrow niches and restricted distributions (i.e., 'short range endemics,' SREs) are particularly vulnerable to climate change. The New Mexico Ridge-nosed Rattlesnake (Crotalus willardi obscurus, CWO), an SRE listed under the U.S. Endangered Species Act within three sky islands of southwestern North America, is constrained at low elevation by drought and at high elevation by wildfire. We combined long-term recapture and molecular data with demographic and niche modeling to gauge its climate-driven status, distribution, and projected longevity. The largest population (Animas) is numerically constricted (N = 151), with few breeding adults (Nb = 24) and an elevated inbreeding coefficient (ΔF = 0.77; 100 years). Mean home range (0.07 km2) is significantly smaller compared to other North American rattlesnakes, and movements are within, not among sky islands. Demographic values, when gauged against those displayed by other endangered/Red-Listed reptiles [e.g., Loggerhead Sea Turtle (Caretta caretta)], are either comparable or markedly lower. Survival rate differs significantly between genders (femaleAdder (Vipera berus), a conservation icon in southern Sweden. Genetic rescue, a management approach successfully employed in similar situations, is ill advised in this situation due to climate-driven habitat change in the sky islands. CWO is a rare organism in a unique environment, with a conserved niche and a predisposition towards extinction. It is a bellwether for the

  6. Nowhere to Go but Up: Impacts of Climate Change on Demographics of a Short-Range Endemic (Crotalus willardi obscurus) in the Sky-Islands of Southwestern North America

    PubMed Central

    Davis, Mark A.; Douglas, Marlis R.; Webb, Colleen T.; Collyer, Michael L.; Holycross, Andrew T.; Painter, Charles W.; Kamees, Larry K.; Douglas, Michael E.

    2015-01-01

    Biodiversity elements with narrow niches and restricted distributions (i.e., ‘short range endemics,’ SREs) are particularly vulnerable to climate change. The New Mexico Ridge-nosed Rattlesnake (Crotalus willardi obscurus, CWO), an SRE listed under the U.S. Endangered Species Act within three sky islands of southwestern North America, is constrained at low elevation by drought and at high elevation by wildfire. We combined long-term recapture and molecular data with demographic and niche modeling to gauge its climate-driven status, distribution, and projected longevity. The largest population (Animas) is numerically constricted (N = 151), with few breeding adults (Nb = 24) and an elevated inbreeding coefficient (ΔF = 0.77; 100 years). Mean home range (0.07km2) is significantly smaller compared to other North American rattlesnakes, and movements are within, not among sky islands. Demographic values, when gauged against those displayed by other endangered/Red-Listed reptiles [e.g., Loggerhead Sea Turtle (Caretta caretta)], are either comparable or markedly lower. Survival rate differs significantly between genders (femaleAdder (Vipera berus), a conservation icon in southern Sweden. Genetic rescue, a management approach successfully employed in similar situations, is ill advised in this situation due to climate-driven habitat change in the sky islands. CWO is a rare organism in a unique environment, with a conserved niche and a predisposition towards extinction. It is a bellwether for the

  7. Cysteine-rich venom proteins from the snakes of Viperinae subfamily - molecular cloning and phylogenetic relationship.

    PubMed

    Ramazanova, Anna S; Starkov, Vladislav G; Osipov, Alexey V; Ziganshin, Rustam H; Filkin, Sergey Yu; Tsetlin, Victor I; Utkin, Yuri N

    2009-01-01

    Cysteine-rich proteins found in animal venoms (CRISP-Vs) are members of a large family of cysteine-rich secretory proteins (CRISPs). CRISP-Vs acting on different ion channels were found in venoms or mRNA (cDNA) encoding CRISP-Vs were cloned from snakes of three main families (Elapidae, Colubridae and Viperidae). About thirty snake CRISP-Vs were sequenced so far, however no complete sequence for CRISP-V from Viperinae subfamily was reported. We have cloned and sequenced for the first time cDNAs encoding CRISP-Vs from Vipera nikolskii and Vipera berus vipers (Viperinae). The deduced mature CRISP-V amino acid sequences consist of 220 amino acid residues. Phylogenetic analysis showed that viper proteins are closely related to those of Crotalinae snakes. The presence of CRISP-V in the V. berus venom was revealed using a combination of gel-filtration chromatography, electrophoresis and MALDI mass spectrometry. The finding of the putative channel blocker in viper venom may indicate its action on prey nervous system. PMID:19041663

  8. [Aggravation of snake bite in France and their treatment].

    PubMed

    de Haro, Luc

    2003-07-12

    VIPERS AT THE ORIGIN OF ENVENOMING: Out of the 4 species of vipers found in France, only two can be responsible for severe envenoming: the aspic viper (Vipera aspis) and the addetr (Vipera berus). CLINICAL GRADING: Since 1992, a grading table published by the Institut Pasteur in Paris helps to assess the severity of the clinical and biological picture. A grade 2 (extensive oedema +/- accompanied by moderate general signs) or notably a grade 3 (giant oedema + severe general signs + biological signs) implies the administration of an antivenom. ANTIVENOM VIPERFAV: Available on the market since 2000, is administered in intravenous infusion, the only route effective. Tolerance to the treatment is good and clinical improvement is rapid after administration of 1 to 4 infusions of antivenom. When confronted with life-threatening envenoming, there is no strong argument to justify the non-use of an antivenom. VIPERINE ENVENOMING: Among the grass snakes, the viperine snake of Montpellier is the only species that is actually venomous. The fangs are posterior in the buccal cavity of the snake, which does not usually permit it to inject its venom in humans. In exceptional circumstances (finger placed in the throat), envenoming has been observed with, in this case, essentially neurological clinical signs: involvement of the cranial nerves, drowsiness. There is no specific treatment for these extremely rare accidents. PMID:12947747

  9. AWAIC: A WISE Astronomical Image Co-adder

    NASA Astrophysics Data System (ADS)

    Masci, Frank J.; Fowler, J. W.; Cutri, R. M.

    2009-05-01

    The Wide-field Infrared Survey Explorer (WISE) is a NASA Midex mission launching in late 2009 that will survey the entire sky at 3.3, 4.7, 12, and 23 microns with sensitivities up to three orders of magnitude beyond those achieved with IRAS. One of its products is a digital Image Atlas that will combine survey exposures within predefined tiles on the sky. To support this, we have developed a generic frame co-addition tool, AWAIC, for execution in the automated pipeline. We review AWAIC's algorithms, functions and products. The software includes preparatory steps such as frame background matching and outlier detection. Frame co-addition is based on using the detector's Point Response Function (PRF) as an interpolation kernel. This kernel reduces the impact of prior-masked pixels; enables the creation of an optimal matched filtered product for point source detection; and most important, it allows for optional resolution enhancement (HiRes) to yield a "model" of the sky that is consistent with the measurements within their uncertainties. This is accomplished through a Richardson-Lucy like procedure, extended to include non-isoplanatic PRFs, prior noise weighting, variance estimation, and ringing suppression. HiRes is not in the WISE automated processing plan. Ancillary products include images of uncertainties, depth-of-coverage, and outlier locations. AWAIC supports the FITS standard with all common projections and coordinate systems. It will be made portable in the near future.

  10. AWAIC: A WISE Astronomical Image Co-adder

    NASA Astrophysics Data System (ADS)

    Masci, Franck J.; Fowler, J.; Cutri, R.; Science Data Center, WISE

    2009-01-01

    The Wide-field Infrared Survey Explorer (WISE) is a NASA Midex mission launching in late 2009 that will survey the entire sky at 3.3, 4.7, 12, and 23 microns with sensitivities up to three orders of magnitude beyond those achieved with IRAS. One of its products is a digital Image Atlas that will combine survey exposures within predefined tiles on the sky. To support this, we have developed a generic frame co-addition tool, AWAIC, for execution in the automated pipeline. Here we describe AWAIC's algorithms, functionality, and products. The software includes preparatory steps such as frame background matching and outlier detection. Frame co-addition is based on using the detector's Point Response Function (PRF) as an interpolation kernel. This kernel reduces the impact of prior-masked pixels; enables the creation of an optimal matched filtered product for point source detection; and most important, it allows for resolution enhancement (HiRes) to yield a "model" of the sky that is consistent with the observations within their uncertainties. This is accomplished through a Richardson-Lucy like procedure, extended to include non-isoplanatic PRFs, prior noise weighting, variance estimation, and ringing-artifact suppression. HiRes is not in the WISE automated processing plan. Ancillary products include images of uncertainties, depth-of-coverage, and outlier locations. AWAIC supports the FITS standard with all common projections and coordinate systems, and will be made portable in the near future.

  11. MULTIPLE INPUT BINARY ADDER EMPLOYING MAGNETIC DRUM DIGITAL COMPUTING APPARATUS

    DOEpatents

    Cooke-Yarborough, E.H.

    1960-12-01

    A digital computing apparatus is described for adding a plurality of multi-digit binary numbers. The apparatus comprises a rotating magnetic drum, a recording head, first and second reading heads disposed adjacent to the first and second recording tracks, and a series of timing signals recorded on the first track. A series of N groups of digit-representing signals is delivered to the recording head at time intervals corresponding to the timing signals, each group consisting of digits of the same significance in the numbers, and the signal series is recorded on the second track of the drum in synchronism with the timing signals on the first track. The multistage registers are stepped cyclically through all positions, and each of the multistage registers is coupled to the control lead of a separate gate circuit to open the corresponding gate at only one selected position in each cycle. One of the gates has its input coupled to the bistable element to receive the sum digit, and the output lead of this gate is coupled to the recording device. The inputs of the other gates receive the digits to be added from the second reading head, and the outputs of these gates are coupled to the adding register. A phase-setting pulse source is connected to each of the multistage registers individually to step the multistage registers to different initial positions in the cycle, and the phase-setting pulse source is actuated each N time interval to shift a sum digit to the bistable element, where the multistage register coupled to bistable element is operated by the phase- setting pulse source to that position in its cycle N steps before opening the first gate, so that this gate opens in synchronism with each of the shifts to pass the sum digits to the recording head.

  12. Cytotoxic Effect of Iranian Vipera lebetina Snake Venom on HUVEC Cells

    PubMed Central

    Kakanj, Maryam; Ghazi-Khansari, Mahmoud; Zare Mirakabadi, Abbas; Daraei, Bahram; Vatanpour, Hossein

    2015-01-01

    Objective: Envenomation by heamotoxic snakes constituted a critical health occurrence in the world. Bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. It is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. This study was carried out to evaluate the direct toxicity effect of V. lebetina crude venom on Human Umbilical Vein Endothelial Cells (HUVECs). Methods: The effect of V. lebetina snake venom on HUVECs growth inhibition was determined by MTT assay and neutral red uptake assay. The integrity of cell membrane through LDH release was measured with the Cytotoxicity Detection Kit. Morphological changes of endothelial cells were also evaluated using a phase contrast microscope. Result: In MTT assay, crude venom showed a cytotoxic effect on endothelial cells which was confirmed by the effect observed with neutral red assay. Also, crude venom caused changes in the integrity of cell membrane by LDH release. The morphological alterations enhanced in high concentration results in total cells number reduced. Conclusion: V. lebetina venom showed potential direct cytotoxic effects on human endothelial cells in a manner of concentration- dependent inhibition. PMID:26185512

  13. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation.

    PubMed

    Lewin, Matthew; Samuel, Stephen; Merkel, Janie; Bickler, Philip

    2016-01-01

    Snakebite remains a neglected medical problem of the developing world with up to 125,000 deaths each year despite more than a century of calls to improve snakebite prevention and care. An estimated 75% of fatalities from snakebite occur outside the hospital setting. Because phospholipase A2 (PLA2) activity is an important component of venom toxicity, we sought candidate PLA2 inhibitors by directly testing drugs. Surprisingly, varespladib and its orally bioavailable prodrug, methyl-varespladib showed high-level secretory PLA2 (sPLA2) inhibition at nanomolar and picomolar concentrations against 28 medically important snake venoms from six continents. In vivo proof-of-concept studies with varespladib had striking survival benefit against lethal doses of Micrurus fulvius and Vipera berus venom, and suppressed venom-induced sPLA2 activity in rats challenged with 100% lethal doses of M. fulvius venom. Rapid development and deployment of a broad-spectrum PLA2 inhibitor alone or in combination with other small molecule inhibitors of snake toxins (e.g., metalloproteases) could fill the critical therapeutic gap spanning pre-referral and hospital setting. Lower barriers for clinical testing of safety tested, repurposed small molecule therapeutics are a potentially economical and effective path forward to fill the pre-referral gap in the setting of snakebite. PMID:27571102

  14. Propensity of crocin to offset Vipera russelli venom induced oxidative stress mediated neutrophil apoptosis: a biochemical insight.

    PubMed

    Santhosh, M Sebastin; Sundaram, M Shanmuga; Sunitha, K; Jnaneshwari, S; Devaraja, S; Kemparaju, K; Girish, K S

    2016-01-01

    Viper envenomation results in inflammation at the bitten site as well as target organs. Neutrophils and other polymorphonuclear leukocytes execute inflammation resolving mechanism and will undergo apoptosis after completing the task. However, the target specific toxins induce neutrophil apoptosis at the bitten site and in circulation prior to their function, thus reducing their number. Circulating activated neutrophils are major source of inflammatory cytokines and leakage of reactive oxygen species (ROS)/other toxic intermediates resulting in aggravation of inflammatory response at the bitten/target site. Therefore, neutralization of venom induced neutrophil apoptosis reduces inflammation besides increasing the functional neutrophil population. Therefore, the present study investigates the venom induced perturbances in isolated human neutrophils and its neutralization by crocin (Crocus sativus) a potent antioxidant carotenoid. Human neutrophils on treatment with venom resulted in altered ROS generation, intracellular Ca(2+) mobilization, mitochondrial membrane depolarization, cyt-c translocation, caspase activation, phosphatidylserine externalization and DNA damage. On the other hand significant protection against oxidative stress and apoptosis were evidenced in crocin pre-treated groups. In conclusion the viper venom induces neutrophil apoptosis and results in aggravation of inflammation and tissue damage. The present study demands the necessity of an auxiliary therapy in addition to antivenin therapy to treat secondary/overlooked complications of envenomation. PMID:25149285

  15. Pencil-like mm-size electron beams produced with linear inductive voltage adders (LIVA)

    SciTech Connect

    Mazarakis, M.G.; Poukey, J.W.; Rovang, D.C.

    1996-09-01

    This paper presents design, analysis, and first results of the high brightness electron beam experiments currently under investigation at Sandia. Anticipated beam parameters are: energy 12 MeV, current 35-40 kA, rms radius 0.5 mm, pulse duration 40 ns FWHM. The accelerator is SABRE, a pulsed LIVA modified to higher impedance, and the electron source is a magnetically immersed foilless electron diode. 20 to 30 Tesla solenoidal magnets are required to insulate the diode and contain the beam to its extremely small sized (1 mm) envelope. These experiments are designed to push the technology to produce the highest possible electron current in a submillimeter radius beam. Design, numercial simulations, and first experimental results are presented.

  16. Costs of venom production in the common death adder (Acanthophis antarcticus).

    PubMed

    Pintor, Anna F V; Krockenberger, Andrew K; Seymour, Jamie E

    2010-11-01

    The utilization of venom in predatory and defensive contexts is associated with benefits regarding minimization of energetic expenditure on hunting, maximization of success in prey acquisition and avoidance of injury from dangerous prey and aggressors. Multiple characteristics suggest that venom is quite expensive to produce, thereby creating a tradeoff between advantages and disadvantages associated with its possession. The metabolic costs of venom production have rarely been studied and no information on the detailed metabolic processes during venom replenishment exists. Where costs of venom production have been studied they are often not in context with other components of the energy budget of the study organism. Using flow-through respirometry, we examined changes in metabolic rate in the Australian elapid Acanthophis antarcticus after venom expenditure and feeding as well as during preparation for shedding to establish a comparison of the magnitude of energetic expenditure during venom replenishment and other common physiological processes. We also defined the temporal pattern of metabolic processes during venom replenishment at a higher resolution than has previously been attempted in snakes. Our results suggest that total costs of venom replenishment are relatively small when compared to costs of digestion and shedding. We conclude that, in spite of the manifold factors suggesting a high cost of venom in snakes, its production is less energetically costly than often assumed. Until further research can clarify the reasons for this more caution should therefore be applied when assuming that costs of venom production exert strong selection pressures on the ecology, behavior and evolution of venomous taxa. PMID:20659494

  17. In Vitro Toxic Effects of Puff Adder (Bitis arietans) Venom, and Their Neutralization by Antivenom

    PubMed Central

    Fernandez, Steven; Hodgson, Wayne; Chaisakul, Janeyuth; Kornhauser, Rachelle; Konstantakopoulos, Nicki; Smith, Alexander Ian; Kuruppu, Sanjaya

    2014-01-01

    This study investigated the in vitro toxic effects of Bitis arietans venom and the ability of antivenom produced by the South African Institute of Medical Research (SAIMR) to neutralize these effects. The venom (50 µg/mL) reduced nerve-mediated twitches of the chick biventer muscle to 19% ± 2% of initial magnitude (n = 4) within 2 h. This inhibitory effect of the venom was significantly attenuated by prior incubation of tissues with SAIMR antivenom (0.864 µg/µL; 67% ± 4%; P < 0.05; n = 3–5, unpaired t-test). Addition of antivenom at t50 failed to prevent further inhibition or reverse the inhibition of twitches and responses to agonists. The myotoxic action of the venom (50 µg/mL) was evidenced by a decrease in direct twitches (30% ± 6% of the initial twitch magnitude) and increase in baseline tension (by 0.7 ± 0.3 g within 3 h) of the chick biventer. Antivenom failed to block these effects. Antivenom however prevented the venom induced cytotoxic effects on L6 skeletal muscle cells. Venom induced a marginal but significant reduction in plasma clotting times at concentrations above 7.8 µg/100 µL of plasma, indicating poor procoagulant effects. In addition, the results of western immunoblotting indicate strong immunoreactivity with venom proteins, thus warranting further detailed studies on the neutralization of the effects of individual venom toxins by antivenom. PMID:24854547

  18. Multi-input and binary reproducible, high bandwidth floating point adder in a collective network

    DOEpatents

    Chen, Dong; Eisley, Noel A; Heidelberger, Philip; Steinmacher-Burow, Burkhard

    2015-03-10

    To add floating point numbers in a parallel computing system, a collective logic device receives the floating point numbers from computing nodes. The collective logic devices converts the floating point numbers to integer numbers. The collective logic device adds the integer numbers and generating a summation of the integer numbers. The collective logic device converts the summation to a floating point number. The collective logic device performs the receiving, the converting the floating point numbers, the adding, the generating and the converting the summation in one pass. One pass indicates that the computing nodes send inputs only once to the collective logic device and receive outputs only once from the collective logic device.

  19. Inhibition of Nicotinic Acetylcholine Receptors, a Novel Facet in the Pleiotropic Activities of Snake Venom Phospholipases A2

    PubMed Central

    Vulfius, Catherine A.; Kasheverov, Igor E.; Starkov, Vladislav G.; Osipov, Alexey V.; Andreeva, Tatyana V.; Filkin, Sergey Yu.; Gorbacheva, Elena V.; Astashev, Maxim E.; Tsetlin, Victor I.; Utkin, Yuri N.

    2014-01-01

    Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis arietans and possessing high phospholipolytic activity, interacts with different types of nicotinic acetylcholine receptors and with the acetylcholine-binding protein. To check if this property is characteristic to all venom phospholipases A2, we have studied the capability of these enzymes from other snakes to block the responses of Lymnaea stagnalis neurons to acetylcholine or cytisine and to inhibit α-bungarotoxin binding to nicotinic acetylcholine receptors and acetylcholine-binding proteins. Here we present the evidence that phospholipases A2 from venoms of vipers Vipera ursinii and V. nikolskii, cobra Naja kaouthia, and krait Bungarus fasciatus from different snake families suppress the acetylcholine- or cytisine-elicited currents in L. stagnalis neurons and compete with α-bungarotoxin for binding to muscle- and neuronal α7-types of nicotinic acetylcholine receptor, as well as to acetylcholine-binding proteins. As the phospholipase A2 content in venoms is quite high, under some conditions the activity found may contribute to the deleterious venom effects. The results obtained suggest that the ability to interact with nicotinic acetylcholine receptors may be a general property of snake venom phospholipases A2, which add a new target to the numerous activities of these enzymes. PMID:25522251

  20. 18 CFR 35.22 - Limits for percentage adders in rates for transmission services; revision of rate schedules...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... that performs a transmission or purchase and resale function for electric power generated by another... Organization Act, 42 U.S.C. 7101-7352; E.O. 12009, 3 CFR 142 (1978)) ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Limits for...

  1. Simultaneous all-optical half-adder, half-subtracter, comparator, and decoder based on nonlinear effects harnessing in highly nonlinear fibers

    NASA Astrophysics Data System (ADS)

    Singh, Karamdeep; Kaur, Gurmeet; Singh, Maninder Lal

    2016-07-01

    A multifunctional combinational logic module capable of performing several signal manipulation tasks all-optically, such as half-addition/subtraction, single-bit comparison, and 2-to-4 decoding simultaneously is proposed. Several logic functions (A+B¯, A.B, A¯.B, A.B¯, A⊕B, and A⊙B) between two input signals A and B are implemented by harnessing a number of nonlinear effects, such as cross-phase modulation (XPM), cross-gain modulation (XGM), and four-wave mixing (FWM) inside only two highly nonlinear fibers (HNLF) arranged in a parallel structure. The NOR gate (A+B¯) is realized by the means of XPM effect in the first HNLF, whereas, A‾.B, A.B¯, and A.B logics have relied on utilization of XGM and FWM processes, respectively, in parametric medium made up of the second HNLF of parallel arrangement. The remaining A⊕B and A⊙B logics required for successful implementation of the proposed simultaneous scheme are attained by temporally combining previously achieved (A‾.B and A.B‾) and (A.B and A+B‾) logics. Quality-factor ≥7.4 and extinction ratio ≥12.30 dB have been achieved at repetition rates of 100 Gbps for all logic functions (A+B‾, A.B, A¯.B, A.B¯, A⊕B, and A⊙B), suggesting successful simultaneous implementation.

  2. African Adders: Partial Characterization of Snake Venoms from Three Bitis Species of Medical Importance and Their Neutralization by Experimental Equine Antivenoms

    PubMed Central

    Paixão-Cavalcante, Danielle; Kuniyoshi, Alexandre K.; Portaro, Fernanda C. V.; da Silva, Wilmar Dias; Tambourgi, Denise V.

    2015-01-01

    Background An alarming number of fatal accidents involving snakes are annually reported in Africa and most of the victims suffer from permanent local tissue damage and chronic disabilities. Envenomation by snakes belonging to the genus Bitis, Viperidae family, are common in Sub-Saharan Africa. The accidents are severe and the victims often have a poor prognosis due to the lack of effective specific therapies. In this study we have biochemically characterized venoms from three different species of Bitis, i.e., Bitis arietans, Bitis gabonica rhinoceros and Bitis nasicornis, involved in the majority of the human accidents in Africa, and analyzed the in vitro neutralizing ability of two experimental antivenoms. Methodology/Principal Findings The data indicate that all venoms presented phospholipase, hyaluronidase and fibrinogenolytic activities and cleaved efficiently the FRET substrate Abz-RPPGFSPFRQ-EDDnp and angiotensin I, generating angiotensin 1–7. Gelatinolytic activity was only observed in the venoms of B. arietans and B. nasicornis. The treatment of the venoms with protease inhibitors indicated that Bitis venoms possess metallo and serinoproteases enzymes, which may be involved in the different biological activities here evaluated. Experimental antivenoms produced against B. arietans venom or Bitis g. rhinoceros plus B. nasicornis venoms cross-reacted with the venoms from the three species and blocked, in different degrees, all the enzymatic activities in which they were tested. Conclusion These results suggest that the venoms of the three Bitis species, involved in accidents with humans in the Sub-Saharan Africa, contain a mixture of various enzymes that may act in the generation and development of some of the clinical manifestations of the envenomations. We also demonstrated that horse antivenoms produced against B. arietans or B. g. rhinoceros plus B. nasicornis venoms can blocked some of the toxic activities of these venoms. PMID:25643358

  3. On the inclusion of prime factors to calculate the theoretical lower bounds in multiplierless single constant multiplications

    NASA Astrophysics Data System (ADS)

    Troncoso Romero, David E.; Meyer-Baese, Uwe; Dolecek, Gordana Jovanovic

    2014-12-01

    This paper presents an extension to the theoretical lower bounds for the number of adders and for the adder depth in multiplierless single constant multiplications (SCM). It is shown that the number of prime factors of the constants is key information to extend the current lower bounds in certain cases that have not yet been exposed. Additionally, the hidden theoretical lower bound for the number of adders required to preserve the minimum adder depth is revealed.

  4. Linear induction accelerator and pulse forming networks therefor

    DOEpatents

    Buttram, Malcolm T.; Ginn, Jerry W.

    1989-01-01

    A linear induction accelerator includes a plurality of adder cavities arranged in a series and provided in a structure which is evacuated so that a vacuum inductance is provided between each adder cavity and the structure. An energy storage system for the adder cavities includes a pulsed current source and a respective plurality of bipolar converting networks connected thereto. The bipolar high-voltage, high-repetition-rate square pulse train sets and resets the cavities.

  5. Linear induction accelerator

    DOEpatents

    Buttram, M.T.; Ginn, J.W.

    1988-06-21

    A linear induction accelerator includes a plurality of adder cavities arranged in a series and provided in a structure which is evacuated so that a vacuum inductance is provided between each adder cavity and the structure. An energy storage system for the adder cavities includes a pulsed current source and a respective plurality of bipolar converting networks connected thereto. The bipolar high-voltage, high-repetition-rate square pulse train sets and resets the cavities. 4 figs.

  6. Exploiting Symmetry for Quantum Error Suppression

    NASA Astrophysics Data System (ADS)

    Nam, Yunseong; Blümel, Reinhold

    2016-05-01

    In light of recent experimental progress in quantum computing, the time is ripe to discuss quantum computer hardware optimization. Taking the digital/analog hybrid nature of quantum computers into account, choosing a proper processor architecture for a given quantum algorithm becomes crucial in making quantum computing a practical reality. As a first step in this direction, we investigate the robustness of quantum adders with respect to naturally occurring hardware defects and errors. In particular, we compare the robustness of the ripple-carry adder to that of the quantum Fourier adder. We show that, surprisingly, when used in Shor's algorithm, the quantum Fourier adder may well be more robust than the ripple-carry adder. We present a noise suppression scheme, called symmetric noise, applicable to the quantum Fourier architecture, that, measured in terms of fidelity, results in an order-of-magnitude performance boost.

  7. MULTI-CHANNEL ELECTRIC PULSE HEIGHT ANALYZER

    DOEpatents

    Gallagher, J.D. et al.

    1960-11-22

    An apparatus is given for converting binary information into coded decimal form comprising means, in combination with a binary adder, a live memory and a source of bigit pulses, for synchronizing the bigit pulses and the adder output pulses; a source of digit pulses synchronized with every fourth bigit pulse; means for generating a conversion pulse in response to the time coincidence of the adder output pulse and a digit pulse: means having a delay equal to two bigit pulse periods coupling the adder output with the memory; means for promptly impressing said conversion pulse on the input of said memory: and means having a delay equal to one bigit pulse period for again impressing the conversion pulse on the input of the memory whereby a fourth bigit adder pulse results in the insertion into the memory of second, third and fourth bigits.

  8. Pipeline active filter utilizing a booth type multiplier

    NASA Technical Reports Server (NTRS)

    Nathan, Robert (Inventor)

    1987-01-01

    Multiplier units of the modified Booth decoder and carry-save adder/full adder combination are used to implement a pipeline active filter wherein pixel data is processed sequentially, and each pixel need only be accessed once and multiplied by a predetermined number of weights simultaneously, one multiplier unit for each weight. Each multiplier unit uses only one row of carry-save adders, and the results are shifted to less significant multiplier positions and one row of full adders to add the carry to the sum in order to provide the correct binary number for the product Wp. The full adder is also used to add this product Wp to the sum of products .SIGMA.Wp from preceding multiply units. If m.times.m multiplier units are pipelined, the system would be capable of processing a kernel array of m.times.m weighting factors.

  9. The effects of environment and physiological cyclicity on the immune system of Viperinae.

    PubMed

    Kobolkuti, Lorand; Cadar, Daniel; Czirjak, Gabor; Niculae, Mihaela; Kiss, Timea; Sandru, Carmen; Spinu, Marina

    2012-01-01

    One of the important aspects of species' survival is connected with global climate changes, which also conditions the epidemiology of infectious diseases. Poikilotherms are exposed, as other species, to climatic influence, especially due to their physiological peculiarities such as important stages of their life cycle: hibernation, shedding, and active phase. The immune system serves as an accurate indicator of the health status and stress levels in these species. This study aimed to monitor the changes of innate (leukocyte subpopulations and total immune globulins) and adaptive immunity (in vitro leukocyte blast transformation) of two viper species, V. berus berus and V. ammodytes ammodytes, endemic in Europe and spread in different regions of Romania during their three major life cycles, hibernation, shedding, and active phase. The results indicated that seasonal variance and cycle rather than species and regional distribution influence the functionality of the immune system. PMID:22547989

  10. Optical guided wave arithmetic

    NASA Astrophysics Data System (ADS)

    McAulay, Alastair D.

    1999-03-01

    Two novel full adder architectures are proposed that can be implemented with optical couplers using fiber optics or integrated optics. The first adder has the advantage over other proposed approaches by requiring only three different component devices: optical logical OR, optical logical NOT, and optical couplers. Configurations of the three components are described that are relatively simple to implement and are expected to function at greater than gigabit per second rates. The second adder requires fewer gates by using additional different gates: analog ADD and thresholding. Methods of implementing in fiber optics and with integrated optics are suggested including the synchronization of the lasers and methods for changing phase. The optical full adder can be used to provide high speed word addition by multiplexing independent addition. The pros and cons of fiber optics versus integrated optics for one architecture versus the other are discussed.

  11. A Path to Discovery

    ERIC Educational Resources Information Center

    Stegemoller, William; Stegemoller, Rebecca

    2004-01-01

    The path taken and the turns made as a turtle traces a polygon are examined to discover an important theorem in geometry. A unique tool, the Angle Adder, is implemented in the investigation. (Contains 9 figures.)

  12. Gate-leakage-tolerant circuits in deep sub-100-nm CMOS technologies

    NASA Astrophysics Data System (ADS)

    Kang, Sung-Mo; Yang, Ge; Wang, Zhongda

    2004-03-01

    The leakage power consumption in deep sub-100nm CMOS systems is projected to become a significant part of the total power dissipation. Although the dual Vt CMOS process helps reduce the subthreshold leakage current, the gate leakage problem poses a significant design challenge. We introduce gate leakage tolerant circuits. We describe two new circuit techniques to suppress gate leakage currents in dual Vt Domino circuits. In standby mode, proposed circuits generate low inputs and low outputs for all Domino stages to suppress gate leakage currents in the NMOS logic tree. Simulation results using 45nm BSIM4 SPICE models for 32-bit adders show that adders using the two proposed circuits can reduce the standby gate leakage by 66% and 90%, respectively. Proposed adders have 7% active power overhead to achieve the same speed as single Vt domino adder and the area penalty is minimal with careful layout.

  13. Antibacterial properties of KwaZulu natal snake venoms.

    PubMed

    Blaylock, R S

    2000-11-01

    The objective was to ascertain whether local snake venoms have antibacterial properties. The venoms of the common night adder (Causus rhombeatus), gaboon adder (Bitis gabonica), puff adder (Bitis arietans), black mamba (Dendroaspis polylepis), eastern green mamba (Dendroaspis augusticeps), forest cobra (Naja melanoleuca), snouted cobra (Naja annulifera) and Mozambique spitting cobra (Naja mossambica) were collected and, by gel diffusion, tested against the bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeriginosa, Bacteriodes fragilis, Bacteroides intermedius, Clostridium sordellii and Clostridium perfringens. All snake venoms showed antibacterial activity, with the adders showing most activity against the aerobes while the cobras showed lesser, but equal activity against the aerobes and anaerobes. Black mamba venom only showed activity against C. perfringens. In conclusion, local snake venoms have antibacterial properties which are dependent on the venom and bacterial type; and in the Naja spp., for anaerobic bacteria, diminish in winter. There is liable to be more than one toxin component responsible. PMID:10775753

  14. Evidence for existence of venom 5' nucleotidase in multiple forms through inhibition of concanavalin A.

    PubMed

    Dhananjaya, B L; Gowda, T V; D'Souza, Cletus J M

    2010-10-01

    Pharmacologically active 5' nucleotidase is a ubiquitously distributed enzyme in snake venoms. In this study the effect of concanavalin A (Con-A) on different snake venoms 5' nucleotidase activity is tested in order to know the protein nature which will ultimately help in purification of the enzyme with high yield. Con-A inhibited Naja naja, Naja kauthia, Naja melanoleuca, Naja naja sputatrix, Agistrodon halys blomhoffii, Bothrops asper and Oxyranus scutellas venom 5' nucleotidase activity at different concentrations. This indicates the presence of glycopart in the protein, thus glycoprotein in nature. Vipera russellii, Vipera plaestenae, Agistrodon contratrix, Bitis orientis, Echis carinatus and Trimeresures malabaricus was not inhibited by Con-A, indicating absence of glycopart in the protein. This study for the first time shows existence of 5' nucleotidase in multimeric forms. PMID:20941753

  15. Raman spectroscopic studies of the skins of the Sahara sand viper, the carpet python and the American black rat snake

    NASA Astrophysics Data System (ADS)

    Edwards, H. G. M.; Farwell, D. W.; Williams, A. C.; Barry, B. W.

    1993-07-01

    Vibrational Raman spectra of the skins of the snakes Cerastes vipera (Sahara sand viper) and Morelia argus (carpet python) have been recorded for the first time using visible and IR laser excitation. Full vibrational assignments are proposed and comparisons made with vibrational Raman spectra of the snake Elaphe obsoleta (American black rat snake); such studies may be important in correlating the permeabilities of human and snake skins to drugs and contaminants.

  16. FPGA-specific decimal sign-magnitude addition and subtraction

    NASA Astrophysics Data System (ADS)

    Vázquez, Martín; Todorovich, Elías

    2016-07-01

    The interest in sign-magnitude (SM) representation in decimal numbers lies in the IEEE 754-2008 standard, where the significand in floating-point numbers is coded as SM. However, software implementations do not meet performance constraints in some applications and more development is required in programmable logic, a key technology for hardware acceleration. Thus, in this work, two strategies for SM decimal adder/subtractors are studied and six new Field Programmable Gate Array (FPGA)-specific circuits are derived from these strategies. The first strategy is based on ten's complement (C10) adder/subtractors and the second one is based on parallel computation of an unsigned adder and an unsigned subtractor. Four of these alternative circuits are useful for at least one area-time-trade-off and specific operand size. For example, the fastest SM adder/subtractor for operand sizes of 7 and 16 decimal digits is based on the second proposed strategy with delays of 3.43 and 4.33 ns, respectively, but the fastest circuit for 34-digit operands is one of the three specific implementations based on C10 adder/subtractors with a delay of 4.65 ns.

  17. ARC length control for plasma welding

    NASA Technical Reports Server (NTRS)

    Iceland, William F. (Inventor)

    1988-01-01

    A control system to be used with a plasma arc welding apparatus is disclosed. The plasma arc welding apparatus includes a plasma arc power supply, a contactor, and an electrode assembly for moving the electrode relative to a work piece. The electrode assembly is raised or lowered by a drive motor. The present apparatus includes a plasma arc adapter connected across the power supply to measure the voltage across the plasma arc. The plasma arc adapter forms a dc output signal input to a differential amplifier. A second input is defined by an adjustable resistor connected to a dc voltage supply to permit operator control. The differential amplifier forms an output difference signal provided to an adder circuit. The adder circuit then connects with a power amplifier which forms the driving signal for the motor. In addition, the motor connects to a tachometor which forms a feedback signal delivered to the adder to provide damping, therby avoiding servo loop overshoot.

  18. Multi-Valued Logic Gates based on Ballistic Transport in Quantum Point Contacts

    PubMed Central

    Seo, M.; Hong, C.; Lee, S.-Y.; Choi, H. K.; Kim, N.; Chung, Y.; Umansky, V.; Mahalu, D.

    2014-01-01

    Multi-valued logic gates, which can handle quaternary numbers as inputs, are developed by exploiting the ballistic transport properties of quantum point contacts in series. The principle of a logic gate that finds the minimum of two quaternary number inputs is demonstrated. The device is scalable to allow multiple inputs, which makes it possible to find the minimum of multiple inputs in a single gate operation. Also, the principle of a half-adder for quaternary number inputs is demonstrated. First, an adder that adds up two quaternary numbers and outputs the sum of inputs is demonstrated. Second, a device to express the sum of the adder into two quaternary digits [Carry (first digit) and Sum (second digit)] is demonstrated. All the logic gates presented in this paper can in principle be extended to allow decimal number inputs with high quality QPCs. PMID:24448272

  19. Integrated-Circuit Active Digital Filter

    NASA Technical Reports Server (NTRS)

    Nathan, R.

    1986-01-01

    Pipeline architecture with parallel multipliers and adders speeds calculation of weighted sums. Picture-element values and partial sums flow through delay-adder modules. After each cycle or time unit of calculation, each value in filter moves one position right. Digital integrated-circuit chips with pipeline architecture rapidly move 35 X 35 two-dimensional convolutions. Need for such circuits in image enhancement, data filtering, correlation, pattern extraction, and synthetic-aperture-radar image processing: all require repeated calculations of weighted sums of values from images or two-dimensional arrays of data.

  20. RITS-3 self-break water switch maintenance.

    SciTech Connect

    Cordova, Steve Ray; Portillo, Salvador; Puetz, Elizabeth A.; Wilkins, Frank Lee; Gignac, Raymond Edward; Johnson, David Lee; Hahn, Kelly Denise; Molina, Isidro; Maenchen, John Eric

    2004-06-01

    The radiographic integrated test stand (RITS-3) is a 5-MV, 160-kA, 70-ns inductive voltage adder accelerator at Sandia National Laboratories used to develop critical understanding of x-ray sources and flash radiographic drivers. On RITS-3 three pulse forming lines (PFLs) are used to drive three inductive voltage adder cavities. Each PFL contains a fast-pulse-charged, self-breakdown annular water switch that is used for initial pulse shaping and timing. Low loss in the switches combined with good synchronization is required for efficient operation of the accelerator. Switch maintenance is closely monitored over time to determine the effects of wear on switch breakdown performance.

  1. DOIND: a technique for leakage reduction in nanoscale domino logic circuits

    NASA Astrophysics Data System (ADS)

    Prasad Shah, Ambika; Neema, Vaibhav; Daulatabad, Shreeniwas

    2016-05-01

    A novel DOIND logic approach is proposed for domino logic, which reduces the leakage current with a minimum delay penalty. Simulation is performed at 70 nm technology node with supply voltage 1V for domino logic and DOIND logic based AND, OR, XOR and Half Adder circuits using the tanner EDA tool. Simulation results show that the proposed DOIND approach decreases the average leakage current by 68.83%, 66.6%, 77.86% and 74.34% for 2 input AND, OR, XOR and Half Adder respectively. The proposed approach also has 47.76% improvement in PDAP for the buffer circuit as compared to domino logic.

  2. A Low Cost Correlator Structure in the Pseudo-Noise Code Acquisition System

    NASA Astrophysics Data System (ADS)

    Lu, Weijun; Li, Ying; Yu, Dunshan; Zhang, Xing

    The critical problem of the pseudo-noise (PN) code acquisition system is the contradiction between the acquisition performance and the calculation complexity. This paper presents a low cost correlator (LCC) structure that can search for two PN code phases in a single accumulation period by eliminating redundant computation. Compared with the part-parallel structure that is composed of two serial correlators (PARALLEL2), the proposed LCC structure has the same performance while saves about 22% chip area and 34% power consumption if uses the Carry-look-ahead (CLA) adder, 17% chip area and 25% power consumption if uses the Ripple-carry (RPL) adder.

  3. Chemical Implementation of Finite-State Machines

    NASA Astrophysics Data System (ADS)

    Hjelmfelt, Allen; Weinberger, Edward D.; Ross, John

    1992-01-01

    With methods developed in a prior article on the chemical kinetic implementation of a McCulloch-Pitts neuron, connections among neurons, logic gates, and a clocking mechanism, we construct examples of clocked finite-state machines. These machines include a binary decoder, a binary adder, and a stack memory. An example of the operation of the binary adder is given, and the chemical concentrations corresponding to the state of each chemical neuron are followed in time. Using these methods, we can, in principle, construct a universal Turing machine, and these chemical networks inherit the halting problem

  4. Sugar-based molecular computing by material implication.

    PubMed

    Elstner, Martin; Axthelm, Jörg; Schiller, Alexander

    2014-07-01

    A method to integrate an (in principle) unlimited number of molecular logic gates to construct complex circuits is presented. Logic circuits, such as half- or full-adders, can be reinterpreted by using the functional completeness of the implication function (IMP) and the trivial FALSE operation. The molecular gate IMP is represented by a fluorescent boronic acid sugar probe. An external wiring algorithm translates the fluorescent output from one gate into a chemical input for the next gate on microtiter plates. This process is demonstrated on a four-bit full adder. PMID:24924187

  5. Open source high performance floating-point modules.

    SciTech Connect

    Underwood, Keith Douglas

    2006-02-01

    Given the logic density of modern FPGAs, it is feasible to use FPGAs for floating-point applications. However, it is important that any floating-point units that are used be highly optimized. This paper introduces an open source library of highly optimized floating-point units for Xilinx FPGAs. The units are fully IEEE compliant and achieve approximately 230 MHz operation frequency for double-precision add and multiply in a Xilinx Virtex-2-Pro FPGA (-7 speed grade). This speed is achieved with a 10 stage adder pipeline and a 12 stage multiplier pipeline. The area requirement is 571 slices for the adder and 905 slices for the multiplier.

  6. Area-efficient nonvolatile carry chain based on pass-transistor/atom-switch hybrid logic

    NASA Astrophysics Data System (ADS)

    Bai, Xu; Tsuji, Yukihide; Sakamoto, Toshitsugu; Morioka, Ayuka; Miyamura, Makoto; Tada, Munehiro; Banno, Naoki; Okamoto, Koichiro; Iguchi, Noriyuki; Hada, Hiromitsu

    2016-04-01

    For the first time, an area-efficient nonvolatile carry chain combining look-up tables and a pass-transistor-logic-based adder is newly developed using complementary atom switches without additional CMOS circuits. A proposed tristate switch composed of three pairs of complementary atom switches selects one of “0”, “1”, and the “carry_in” signal as the input of a common multiplexer for both a look-up table and an adder. The developed nonvolatile carry chain achieves the reductions of 20% area, 17% delay, and 17% power consumption, respectively, in comparison with a conventional nonvolatile carry chain using dedicated CMOS gates.

  7. A recent evaluation of the lethal potencies of ammodytoxins.

    PubMed

    Prijatelj-Žnidaršič, Petra; Pungerčar, Jože

    2012-05-01

    Ammodytoxin A (AtxA) is the most toxic secreted phospholipase A(2) of the three isotoxins with presynaptic neurotoxicity, isolated from the venom of the nose-horned viper (Vipera ammodytes ammodytes), with an LD(50) of 21 μg/kg in mice. The toxic potencies of two other isoforms have been re-evaluated using highly purified recombinant proteins, with their intraperitoneal LD(50)s determined as 960 μg/kg for AtxB and 310 μg/kg for AtxC. AtxB and AtxC differ from AtxA in only three and two amino acid residues, respectively. PMID:22406514

  8. [Local complications after poisonous snake bite].

    PubMed

    Kuzbari, R; Seidler, D; Deutinger, M

    1994-01-01

    The case of a zoo keeper who was bitten on the left finger by a venomous snake (Vipera xanthina) is reported. The administration of antivenom prevented the development of systemic poisoning but had no effect on the extent of the local complications. A compartment syndrome with a concomitant severe reaction at the bite site required fasciotomy of the upper and lower arm. The extensor tendon of the involved finger ruptured spontaneously, many weeks after wound healing was completed. Therefore, delayed local complications following snake bites may occur, even if signs of systemic poisoning are missing. PMID:8150389

  9. Particle-free mask handling techniques and a dual-pod carrier

    NASA Astrophysics Data System (ADS)

    Amemiya, Mitsuaki; Ota, Kazuya; Taguchi, Takao; Kamono, Takashi; Usui, Youichi; Takikawa, Tadahiko; Suga, Osamu

    2008-03-01

    In EUV lithography, particle-free handling is one of the critical issues because a pellicle is impractical due to its high absorption. To investigate this subject, we have developed a mask protection engineering tool that allows various types of tests to be carried out during the transfer of a mask or blank in air and in vacuum. We measured the number of particle adders during the transfer of a mask blank in a dual-pod carrier and in an RSP200 carrier. We found that the number of particle adders (>=46 nm PSL) to a mask blank in a dual pod is less than 0.01 over the whole process from taking the blank out of the load port in air to putting it in the electrostatic chuck chamber in vacuum. Through various experiments, the number of particle adders during any process using a dual pod was found to be very few and very stable. In contrast, for a naked mask, many particle adders were found in large variations. Below one particle were added in over 80% of experiments on a dual pod and in about 20% of experiments on a naked mask. Based on the test results, we can conclude that the use of dual pod is an excellent particle-free transfer technique.

  10. Correctness properties for iterated hardware structures

    NASA Technical Reports Server (NTRS)

    Windley, Phillip J.

    1993-01-01

    Iterated structures occur frequently in hardware. This paper describes properties required of mathematical relations that can be implemented iteratively and demonstrates the use of these properties on a generalized class of adders. This work provides a theoretical basis for the correct synthesis of iterated arithmetic structures.

  11. A Digitally Addressable Random-Access Image Selector and Random-Access Audio System.

    ERIC Educational Resources Information Center

    Bitzer, Donald L.; And Others

    The requirements of PLATO IV, a computer based education system at the University of Illinois, have led to the development of an improved, digitally addressable, random access image selector and a digitally addressable, random access audio device. Both devices utilize pneumatically controlled mechanical binary adders to position the mecahnical…

  12. A class of orthogonal nonrecursive binomial filters.

    NASA Technical Reports Server (NTRS)

    Haddad, R. A.

    1971-01-01

    The time- and frequency-domain properties of the orthogonal binomial sequences are presented. It is shown that these sequences, or digital filters based on them, can be generated using adders and delay elements only. The frequency-domain behavior of these nonrecursive binomial filters suggests a number of applications as low-pass Gaussian filters or as inexpensive bandpass filters.

  13. Environmental externality surcharges in power system planning: A case study of New England

    SciTech Connect

    Busch, J.F. Jr; Krause, F.L. )

    1993-08-01

    In several states, public utility commissions have adopted surcharges for environmental externalities (adders) to be used in electric utility planning. The Massachusetts adder system applies major surcharges to emissions of sulfur dioxide, nitrogen oxides, and carbon dioxide. In this paper the authors explore the implications in terms of cost and emissions of using the Massachusetts adders as shadow prices in dispatching the pooled electric power system in New England. Their analysis has made use of a probabilistic production cost simulation model to estimate the impacts on the present system, and on a resource mix envisioned 15 years hence. The externality cost adders are used to influence the dispatch of a fixed configuration of power plants and not used to affect the composition of the future resource mix. Compared to conventional dispatch, emissions of SO[sub 2] and NO[sub x] drop by 10% to 15%, while carbon emissions remain virtually unaffected. The production cost penalty is 3% to 4%. In each year, reductions are accomplished mainly by shifting generation away from New England's coal steam power plants.

  14. Labor costing for HANDI 2000 business management system

    SciTech Connect

    Wilson, D.

    1998-08-24

    Costing labor in the Financial Data System has traditionally been done using standard rates based on type of employee by organization. This methodology will change with the implementation of the PeopleSoft financial system. Labor in the new environment will be cost against actual dollars and marked up with an employee adder, to cover absences and fringe benefits.

  15. Optical logic gates employing liquid crystal optical switches.

    PubMed

    Khan, A H; Nejib, U R

    1987-01-15

    This paper describes very simple optical logic gates consisting of liquid crystal optical switches. This technique was used to implement all possible 2-operand Boolean functions. The importance of these systems in making optical computers is discussed in terms of a binary half-adder and a flip-flop. A new algebra governing the function of these systems is also proposed. PMID:20454123

  16. Quantitative Proteomic Analysis of Venoms from Russian Vipers of Pelias Group: Phospholipases A2 are the Main Venom Components

    PubMed Central

    Kovalchuk, Sergey I.; Ziganshin, Rustam H.; Starkov, Vladislav G.; Tsetlin, Victor I.; Utkin, Yuri N.

    2016-01-01

    Venoms of most Russian viper species are poorly characterized. Here, by quantitative chromato-mass-spectrometry, we analyzed protein and peptide compositions of venoms from four Vipera species (V. kaznakovi, V. renardi, V. orlovi and V. nikolskii) inhabiting different regions of Russia. In all these species, the main components were phospholipases A2, their content ranging from 24% in V. orlovi to 65% in V. nikolskii. Altogether, enzyme content in venom of V. nikolskii reached ~85%. Among the non-enzymatic proteins, the most abundant were disintegrins (14%) in the V. renardi venom, C-type lectin like (12.5%) in V. kaznakovi, cysteine-rich venom proteins (12%) in V. orlovi and venom endothelial growth factors (8%) in V. nikolskii. In total, 210 proteins and 512 endogenous peptides were identified in the four viper venoms. They represented 14 snake venom protein families, most of which were found in the venoms of Vipera snakes previously. However, phospholipase B and nucleotide degrading enzymes were reported here for the first time. Compositions of V. kaznakovi and V. orlovi venoms were described for the first time and showed the greatest similarity among the four venoms studied, which probably reflected close relationship between these species within the “kaznakovi” complex. PMID:27077884

  17. The Management of Pit Viper Envenomation of the Hand

    PubMed Central

    Kulahci, Yalcin; Zor, Fatih; Kapi, Emin

    2008-01-01

    Snakebites are common among the rural population of developing countries. The severity of venomous snakebites depends on several factors, including the location of the bite, the amount of venom injected, and the effectiveness of the initial therapy. Snakebites frequently occur in the extremities with approximately two thirds of envenomations occurring in the upper extremities. In this study, we presented 12 cases of hand reconstruction after Vipera snakebites and discussed how to minimize functional loss and maximize hand rehabilitation. Twelve patients bitten by Vipera between 2001 and 2006 were included in this study. Groin flaps were performed in three cases, full-thickness grafts in two cases, thenar flaps in three cases, and cross finger flaps in three cases. With medical management, spontaneous healing occurred in one case. We prefer to use flaps on the volar site of the hand and, if the bone is not exposed, full-thickness grafts on the dorsal site of the hand. We also recommend starting rehabilitation of the hand early. PMID:18780013

  18. Amplitude Control of Solid-State Modulators for Precision Fast Kicker Applications

    SciTech Connect

    Watson, J A; Anaya, R M; Caporaso, G C; Chen, Y J; Cook, E G; Lee, B S; Hawkins, A

    2002-11-15

    A solid-state modulator with very fast rise and fall times, pulse width agility, and multi-pulse burst and intra-pulse amplitude adjustment capability for use with high speed electron beam kickers has been designed and tested at LLNL. The modulator uses multiple solid-state modules stacked in an inductive-adder configuration. Amplitude adjustment is provided by controlling individual modules in the adder, and is used to compensate for transverse e-beam motion as well as the dynamic response and beam-induced steering effects associated with the kicker structure. A control algorithm calculates a voltage based on measured e-beam displacement and adjusts the modulator to regulate beam centroid position. This paper presents design details of amplitude control along with measured performance data from kicker operation on the ETA-II accelerator at LLNL.

  19. Solid-State Kicker Pulser for DARHT-2

    SciTech Connect

    Cook, E G; Lee, B S; Hawkins, S A; Allen, F V; Hickman, B C; Sullivan, J S; Brooksby, C A

    2001-06-07

    To replace a hard tube design, a solid-state kicker pulser for the Dual-Axis Radiographic Hydrodynamic Test facility (DARHT-2) has been designed and tested. This kicker modulator uses multiple solid-state modules stacked in an inductive-adder configuration where the energy is switched into each section of the adder by a parallel array of MOSFETs. The modulator features very fast rise and fall times, pulse width agility and a high pulse-repetition rate in burst mode. The modulator can drive a 50{Omega} load with voltages up to 20 kV and can be easily configured for either positive or negative polarity. The presentation will include test and operational data.

  20. Probing and exploiting the chaotic dynamics of a hydrodynamic photochemical oscillator to implement all the basic binary logic functions.

    PubMed

    Hayashi, Kenta; Gotoda, Hiroshi; Gentili, Pier Luigi

    2016-05-01

    The convective motions within a solution of a photochromic spiro-oxazine being irradiated by UV only on the bottom part of its volume, give rise to aperiodic spectrophotometric dynamics. In this paper, we study three nonlinear properties of the aperiodic time series: permutation entropy, short-term predictability and long-term unpredictability, and degree distribution of the visibility graph networks. After ascertaining the extracted chaotic features, we show how the aperiodic time series can be exploited to implement all the fundamental two-inputs binary logic functions (AND, OR, NAND, NOR, XOR, and XNOR) and some basic arithmetic operations (half-adder, full-adder, half-subtractor). This is possible due to the wide range of states a nonlinear system accesses in the course of its evolution. Therefore, the solution of the convective photochemical oscillator results in hardware for chaos-computing alternative to conventional complementary metal-oxide semiconductor-based integrated circuits. PMID:27249942

  1. Probing and exploiting the chaotic dynamics of a hydrodynamic photochemical oscillator to implement all the basic binary logic functions

    NASA Astrophysics Data System (ADS)

    Hayashi, Kenta; Gotoda, Hiroshi; Gentili, Pier Luigi

    2016-05-01

    The convective motions within a solution of a photochromic spiro-oxazine being irradiated by UV only on the bottom part of its volume, give rise to aperiodic spectrophotometric dynamics. In this paper, we study three nonlinear properties of the aperiodic time series: permutation entropy, short-term predictability and long-term unpredictability, and degree distribution of the visibility graph networks. After ascertaining the extracted chaotic features, we show how the aperiodic time series can be exploited to implement all the fundamental two-inputs binary logic functions (AND, OR, NAND, NOR, XOR, and XNOR) and some basic arithmetic operations (half-adder, full-adder, half-subtractor). This is possible due to the wide range of states a nonlinear system accesses in the course of its evolution. Therefore, the solution of the convective photochemical oscillator results in hardware for chaos-computing alternative to conventional complementary metal-oxide semiconductor-based integrated circuits.

  2. System for adjusting frequency of electrical output pulses derived from an oscillator

    DOEpatents

    Bartholomew, David B.

    2006-11-14

    A system for setting and adjusting a frequency of electrical output pulses derived from an oscillator in a network is disclosed. The system comprises an accumulator module configured to receive pulses from an oscillator and to output an accumulated value. An adjustor module is configured to store an adjustor value used to correct local oscillator drift. A digital adder adds values from the accumulator module to values stored in the adjustor module and outputs their sums to the accumulator module, where they are stored. The digital adder also outputs an electrical pulse to a logic module. The logic module is in electrical communication with the adjustor module and the network. The logic module may change the value stored in the adjustor module to compensate for local oscillator drift or change the frequency of output pulses. The logic module may also keep time and calculate drift.

  3. Design of Pipeline Multiplier Based on Modified Booth's Algorithm and Wallace Tree

    NASA Astrophysics Data System (ADS)

    Yao, Aihong; Li, Ling; Sun, Mengzhe

    A design of 32*32 bit pipelined multiplier is presented in this paper. The proposed multiplier is based on the modified booth algorithm and Wallace tree structure. In order to improve the throughput rate of the multiplier, pipeline architecture is introduced to the Wallace tree. Carry Select Adder is deployed to reduce the propagation delay of carry signal for the final level 64-bit adder. The multiplier is fully implemented with Verilog HDL and synthesized successfully with Quartus II. The experiment result shows that the resource consumption and power consumption is reduced to 2560LE and 120mW, the operating frequency is improved from 136.21MHz to 165.07MHz.

  4. Optimization of high speed pipelining in FPGA-based FIR filter design using genetic algorithm

    NASA Astrophysics Data System (ADS)

    Meyer-Baese, Uwe; Botella, Guillermo; Romero, David E. T.; Kumm, Martin

    2012-06-01

    This paper compares FPGA-based full pipelined multiplierless FIR filter design options. Comparison of Distributed Arithmetic (DA), Common Sub-Expression (CSE) sharing and n-dimensional Reduced Adder Graph (RAG-n) multiplierless filter design methods in term of size, speed, and A*T product are provided. Since DA designs are table-based and CSE/RAG-n designs are adder-based, FPGA synthesis design data are used for a realistic comparison. Superior results of a genetic algorithm based optimization of pipeline registers and non-output fundamental coefficients are shown. FIR filters (posted as open source by Kastner et al.) for filters in the length from 6 to 151 coefficients are used.

  5. ZX Pulsed-Power Design

    SciTech Connect

    Corley, J.P.; Johnson, D.L.; McDaniel, D.H.; Spielman, R.B.; Struve, K.W.; Stygar, W.A.

    1999-08-02

    ZX is a new z-pinch accelerator planned as the next generation z-pinch driver at SNL, and as an intermediate step towards X-1. It is planned to drive either a single 50 MA z-pinch load, or two 25 to 30 MA z pinches. Three designs for the ZX accelerator are presented. All require 7 to 8 MV at the insulator stack to drive the z-pinch load to implosion in 100 to 120 ns. Two of the designs are based on the Z accelerator, and use water-line technology; a transit-time-isolated water adder, and a water transformer. The third design uses inductive-voltage adders in water. They also describe a low-inductance insulator stack design that helps minimize voltage requirements. This design is evaluated for water and vacuum break-down using JCM, THM, and magnetic-flashover-inhibition criteria.

  6. Neural network chips for trigger purposes in high energy physics

    SciTech Connect

    Gemmeke, H.; Eppler, W.; Fischer, T.

    1996-12-31

    Two novel neural chips SAND (Simple Applicable Neural Device) and SIOP (Serial Input - Operating Parallel) are described. Both are highly usable for hardware triggers in particle physics. The chips are optimized for a high input data rate at a very low cost basis. The performance of a single SAND chip is 200 MOPS due to four parallel 16 bit multipliers and 40 bit adders working in one clock cycle. The chip is able to implement feedforward neural networks, Kohonen feature maps and radial basis function networks. Four chips will be implemented on a PCI-board for simulation and on a VUE board for trigger and on- and off-line analysis. For small sized feedforward neural networks the bit-serial neuro-chip SIOP may lead to even smaller latencies because each synaptic connection is implemented by its own bit serial multiplier and adder.

  7. A tight-binding study of logic gate circuits for adding numbers inside a molecule

    NASA Astrophysics Data System (ADS)

    Stadler, R.; Ami, S.; Forshaw, M.; Joachim, C.

    2002-06-01

    The possibilities for the design of larger diode logic circuits such as a one-bit half-adder inside a molecule are investigated, based on a recent extension of the elastic scattering quantum chemistry technique. Since any diode logic circuit for an adder needs OR-gates and AND-gates as basic components and the properties of OR-gates have already been discussed in the ballistic and tunnelling electron transport regime, we focus on the more complicated AND-gates in the present work. For this case the output current, calculated from the transmission coefficients by using the Landauer-Büttiker formula, shows four different logical levels instead of two. The origin of this level variety is analysed in detail. The concept of programmable gate logic arrays is also addressed, where for intra-molecular circuits distinct deviations from earlier macroscopic or mesoscopic implementations of this scheme are found.

  8. Design and implementation of photon correlator based on C8051F

    NASA Astrophysics Data System (ADS)

    Shen, Jin; Li, Yuming; Liu, Wei; Yang, Yan; Cheng, Yanting

    2008-02-01

    Correlation techniques are widely used to extract spectral information from light scattering and other stochastic processes. Within the photon correlation system, the correlating operation must work at a high speed. In this paper, a photon correlator based on microcontroller C8051F was developed. In the photon correlator, the work of counting and scratch is completed by the two 4-bits binary adder 74F161, which is connected to form an 8-bits adder., and the correlation operation of every channel is carried out by the software of C8051F. By probably choosing high speed devices counting of 10ns in width pulses can be counted. The correlation operations including multiplying and addition operation of 56 channels with the circulation program within 3μs were made in interrupt service routine of the C8051F. The work in this paper can be applied in the ultra-fine particle sizing with photon correlation spectroscopy.

  9. A novel generalized design methodology and realization of Boolean operations using DNA.

    PubMed

    Zoraida, B S E; Arock, Michael; Ronald, B S M; Ponalagusamy, R

    2009-09-01

    The biological deoxyribonucleic acid (DNA) strand has been increasingly seen as a promising computing unit. A new algorithm is formulated in this paper to design any DNA Boolean operator with molecular beacons (MBs) as its input. Boolean operators realized using the proposed design methodology is presented. The developed operators adopt a uniform representation for logical 0 and 1 for any Boolean operator. The Boolean operators designed in this work employ only a hybridization operation at each stage. Further, this paper for the first time brings out the realization of a binary adder and subtractor using molecular beacons. Simulation results of the DNA-based binary adder and subtractor are given to validate the design. PMID:19505531

  10. Technical review of externalities issues. Final report

    SciTech Connect

    Niemeyer, V.

    1994-12-01

    Externalities has become the catchword for a major experiment in electric utility regulation. Together with increased competition as a means for economic regulation, this experiment represents a potential revolution in how electric utilities are regulated. It is very important for utilities and policy makers to understand the technical issues and arguments driving the externality experiment. This Technical Review presents four papers covering topics in economics that may play important roles in this revolution. The four papers are: Economic Issues in the Application of Externalities to Electricity Resource Selection; Climate Change, the Marginal Cost of Carbon Dioxide Emissions and the Implications for Carbon Dioxide Emissions Adders; Positive Externalities and Benefits from Electricity; and Socioeconomic Effects of Externality Adders for Electric Utility Emissions.

  11. Wavelet analysis and HHG in nanorings: their applications in logic gates and memory mass devices

    NASA Astrophysics Data System (ADS)

    Cricchio, Dario; Fiordilino, Emilio

    2016-01-01

    We study the application of one nanoring driven by a laser field in different states of polarization in logic circuits. In particular we show that assigning Boolean values to different states of the incident laser field and to the emitted signals, we can create logic gates such as OR, XOR and AND. We also show the possibility of making logic circuits such as half-adder and full-adder using one and two nanorings respectively. Using two nanorings we made the Toffoli gate. Finally we use the final angular momentum acquired by the electron to store information and hence show the possibility of using an array of nanorings as a mass memory device.

  12. Wavelet analysis and HHG in nanorings: their applications in logic gates and memory mass devices.

    PubMed

    Cricchio, Dario; Fiordilino, Emilio

    2016-01-28

    We study the application of one nanoring driven by a laser field in different states of polarization in logic circuits. In particular we show that assigning Boolean values to different states of the incident laser field and to the emitted signals, we can create logic gates such as OR, XOR and AND. We also show the possibility of making logic circuits such as half-adder and full-adder using one and two nanorings respectively. Using two nanorings we made the Toffoli gate. Finally we use the final angular momentum acquired by the electron to store information and hence show the possibility of using an array of nanorings as a mass memory device. PMID:26662194

  13. Quantum Realization of Arnold Scrambling for IFRQI

    NASA Astrophysics Data System (ADS)

    Sang, Jianzhi; Wang, Shen; Shi, Xue; Li, Qiong

    2016-08-01

    This paper is concerned with the feasibility of the Arnold scrambling based on Improved Flexible Representation of Quantum Images (IFRQI). Firstly, the flexible representation of quantum image is updated to the improved flexible representation of quantum image (IFRQI) to represent a quantum image with arbitrary size L × B. Then, by making use of Control-NOT gate and Adder-Modular operation, the concrete quantum circuit of Arnold scrambling for IFRQI is designed. Simulation results show the effectiveness of the proposed circuit.

  14. Advances in pulsed-power-driven radiography system design.

    SciTech Connect

    Portillo, Salvador; Hinshelwood, David D.; Rovang, Dean Curtis; Cordova, Steve Ray; Oliver, Bryan Velten; Weber, Bruce V.; Welch, Dale Robert; Shelton, Bradley Allen; Sceiford, Matthew E.; Cooperstein, Gerald; Gignac, Raymond Edward; Puetz, Elizabeth A.; Rose, David Vincent; Barker, Dennis L.; Van De Valde, David M.; Droemer, Darryl W.; Wilkins, Frank Lee; Molina, Isidro; Jaramillo, Deanna M.; Swanekamp, Stephen Brian; Commisso, Robert J.; Bailey, Vernon Leslie; Maenchen, John Eric; Johnson, David Lee; Griffin, Fawn A.; Hahn, Kelly Denise; Smith, Ian

    2004-07-01

    Flash x-ray radiography has undergone a transformation in recent years with the resurgence of interest in compact, high intensity pulsed-power-driven electron beam sources. The radiographic requirements and the choice of a consistent x-ray source determine the accelerator parameters, which can be met by demonstrated Induction Voltage Adder technologies. This paper reviews the state of the art and the recent advances which have improved performance by over an order of magnitude in beam brightness and radiographic utility.

  15. Advances in post AFM repair cleaning of photomask with CO2 cryogenic aerosol technology

    NASA Astrophysics Data System (ADS)

    Bowers, Charles; Varghese, Ivin; Balooch, Mehdi; Brandt, Werner

    2009-04-01

    As the mask technology matures, critical printing features and sub-resolution assist features (SRAF) shrink below 100 nm, forcing critical cleaning processes to face significant challenges. These challenges include use of new materials, oxidation, chemical contamination sensitivity, proportionally decreasing printable defect size, and a requirement for a damage-free clean. CO2 cryogenic aerosol cleaning has the potential to offer a wide process window for meeting these new challenges, if residue adder issues and damage can be eliminated. Some key differentiations of CO2 cryogenic aerosol cleaning are the non-oxidizing and non-etching properties compared to conventional chemical wet clean processes with or without megasonics. In prior work, the feasibility of CO2 cryogenic aerosol in post AFM repair photomask cleaning was demonstrated. In this paper, recent advancements of CO2 cryogenic aerosol cleaning technology are presented, focusing on the traditional problem areas of particle adders, electrostatic discharge (ESD), and mask damage mitigation. Key aspects of successful CO2 cryogenic aerosol cleaning include the spray nozzle design, CO2 liquid purity, and system design. The design of the nozzle directly controls the size, density, and velocity of the CO2 snow particles. Methodology and measurements of the solid CO2 particle size and velocity distributions will be presented, and their responses to various control parameters will be discussed. Adder control can be achieved only through use of highly purified CO2 and careful materials selection. Recent advances in CO2 purity will be discussed and data shown. The mask cleaning efficiency by CO2 cryogenic aerosol and damage control is essentially an optimization of the momentum of the solid CO2 particles and elimination of adders. The previous damage threshold of 150 nm SRAF structures has been reduced to 70nm and data will be shown indicating 60 nm is possible in the near future. Data on CO2 tribocharge mitigation

  16. Terahertz-optical-asymmetric-demultiplexer (TOAD)-based arithmetic units for ultra-fast optical information processing

    NASA Astrophysics Data System (ADS)

    Cherri, Abdallah K.

    2010-04-01

    In this paper, designs of ultra-fast all-optical based Terahertz-optical-asymmetric-demultiplexer (TOAD)-based devices are reported. Using TOAD switches, adders/subtracters units are demonstrated. The high speed is achieved due to the use of the nonlinear optical materials and the nonbinary modified signed-digit (MSD) number representation. The proposed all-optical circuits are compared in terms of numbers TOAD switches, optical amplifiers and wavelength converters.

  17. An extremum-seeking MHD generator channel flow control system

    SciTech Connect

    Vasil`ev, V.V.

    1995-01-01

    Progress in the development and study of new electric energy generation methods, based on direct conversion of heat energy, raises the problem of more effective use of their power characteristics. A self-optimizing control system for an object with a unimodal quality function has been developed. The system consists of the object, a divider, a band-pass filter, an averaging filter, a multiplier, a final control element, an adder, and a search signal generator.

  18. Quantum Realization of Arnold Scrambling for IFRQI

    NASA Astrophysics Data System (ADS)

    Sang, Jianzhi; Wang, Shen; Shi, Xue; Li, Qiong

    2016-04-01

    This paper is concerned with the feasibility of the Arnold scrambling based on Improved Flexible Representation of Quantum Images (IFRQI). Firstly, the flexible representation of quantum image is updated to the improved flexible representation of quantum image (IFRQI) to represent a quantum image with arbitrary size L × B. Then, by making use of Control-NOT gate and Adder-Modular operation, the concrete quantum circuit of Arnold scrambling for IFRQI is designed. Simulation results show the effectiveness of the proposed circuit.

  19. Adiabatic circuits: converter for static CMOS signals

    NASA Astrophysics Data System (ADS)

    Fischer, J.; Amirante, E.; Bargagli-Stoffi, A.; Schmitt-Landsiedel, D.

    2003-05-01

    Ultra low power applications can take great advantages from adiabatic circuitry. In this technique a multiphase system is used which consists ideally of trapezoidal voltage signals. The input signals to be processed will often come from a function block realized in static CMOS. The static rectangular signals must be converted for the oscillating multiphase system of the adiabatic circuitry. This work shows how to convert the input signals to the proposed pulse form which is synchronized to the appropriate supply voltage. By means of adder structures designed for a 0.13µm technology in a 4-phase system there will be demonstrated, which additional circuits are necessary for the conversion. It must be taken into account whether the data arrive in parallel or serial form. Parallel data are all in one phase and therefore it is advantageous to use an adder structure with a proper input stage, e.g. a Carry Lookahead Adder (CLA). With a serial input stage it is possible to read and to process four signals during one cycle due to the adiabatic 4-phase system. Therefore input signals with a frequency four times higher than the adiabatic clock frequency can be used. This reduces the disadvantage of the slow clock period typical for adiabatic circuits. By means of an 8 bit Ripple Carry Adder (8 bit RCA) the serial reading will be introduced. If the word width is larger than 4 bits the word can be divided in 4 bit words which are processed in parallel. This is the most efficient way to minimize the number of input lines and pads. At the same time a high throughput is achieved.

  20. DUMPING COOLED MOLDS FROM THE SHAKE OUT RAILS ONTO A ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DUMPING COOLED MOLDS FROM THE SHAKE OUT RAILS ONTO A VIBRATING CONVEYOR WHICH TRANSPORTS CASTINGS AND SAND TO A SEPARATION SCREEN WHICH SIFTS SAND ONTO BELT CONVEYORS BELOW THAT CARRY IT PAST SWITCH-ACTIVATED WATER INJECTORS TO SIMILAR SWITCH-ACTIVATED FRESH SAND ADDERS BEFORE TRANSPORTING IT TO THE SAND STORAGE BIN WHILE CASTINGS ARE EITHER MANUALLY OR SMALL CRANE LIFTED TO DEGATING AREAS. - Southern Ductile Casting Company, Centerville Foundry, 101 Airport Road, Centreville, Bibb County, AL

  1. Direct nephrotoxicity of Russell's viper venom demonstrated in the isolated perfused rat kidney.

    PubMed

    Ratcliffe, P J; Pukrittayakamee, S; Ledingham, J G; Warrell, D A

    1989-03-01

    Envenoming by Russell's Viper (Vipera russelli) is an important cause of acute renal failure. The mechanism of renal damage is unresolved. It is difficult to obtain evidence of a direct nephrotoxic action because of the coincidental disturbance to the systemic circulation. We studied the action of Russell's Viper venom on the function of the isolated perfused rat kidney. Direct nephrotoxic action was indicated by a dose dependent decrease in inulin clearance and an increase in fractional excretion of sodium seen at venom concentrations down to 50 ng/ml, a concentration likely to be achieved in the human circulation after envenoming. The isolated perfused kidney was also used to assess the efficiency of antivenom and for a comparison with snake venoms from the Thai cobra (Naja kauothia) and the Nigerian Saw-Scaled Viper (Echis ocellatus). PMID:2929855

  2. Dynamic SVL and body bias for low leakage power and high performance in CMOS digital circuits

    NASA Astrophysics Data System (ADS)

    Deshmukh, Jyoti; Khare, Kavita

    2012-12-01

    In this article, a new complementary metal oxide semiconductor design scheme called dynamic self-controllable voltage level (DSVL) is proposed. In the proposed scheme, leakage power is controlled by dynamically disconnecting supply to inactive blocks and adjusting body bias to further limit leakage and to maintain performance. Leakage power measurements at 1.8 V, 75°C demonstrate power reduction by 59.4% in case of 1 bit full adder and by 43.0% in case of a chain of four inverters using SVL circuit as a power switch. Furthermore, we achieve leakage power reduction by 94.7% in case of 1 bit full adder and by 91.8% in case of a chain of four inverters using dynamic body bias. The forward body bias of 0.45 V applied in active mode improves the maximum operating frequency by 16% in case of 1 bit full adder and 5.55% in case of a chain of inverters. Analysis shows that additional benefits of using the DSVL and body bias include high performance, low leakage power consumption in sleep mode, single threshold implementation and state retention even in standby mode.

  3. Novel designs of nanometric parity preserving reversible compressor

    NASA Astrophysics Data System (ADS)

    Shoaei, Soghra; Haghparast, Majid

    2014-08-01

    Reversible logic is a new field of study that has applications in optical information processing, low power CMOS design, DNA computing, bioinformatics, and nanotechnology. Low power consumption is a basic issue in VLSI circuits today. To prevent the distribution of errors in the quantum circuit, the reversible logic gates must be converted into fault-tolerant quantum operations. Parity preserving is used to realize fault tolerant in this circuits. This paper proposes a new parity preserving reversible gate. We named it NPPG gate. The most significant aspect of the NPPG gate is that it can be used to produce parity preserving reversible full adder circuit. The proposed parity preserving reversible full adder using NPPG gate is more efficient than the existing designs in term of quantum cost and it is optimized in terms of number of constant inputs and garbage outputs. Compressors are of importance in VLSI and digital signal processing applications. Effective VLSI compressors reduce the impact of carry propagation of arithmetic operations. They are built from the full adder blocks. We also proposed three new approaches of parity preservation reversible 4:2 compressor circuits. The third design is better than the previous two in terms of evaluation parameters. The important contributions have been made in the literature toward the design of reversible 4:2 compressor circuits; however, there are not efforts toward the design of parity preservation reversible 4:2 compressor circuits. All the scales are in the nanometric criteria.

  4. Status of magnetically-insulated power transmission theory

    SciTech Connect

    Mendel, C.W. Jr.

    1995-12-31

    The theory of magnetically-insulated power flow has improved dramatically over the last two decades since the early works of Creedon, Lovelace and Ott, Ron, Mondelli, and Rostoker, and of Bergeron. During the intervening years theoretical improvements included a complete general kinetic theory that involved distributions of electrons based on quasi-conserved canonical variables and was used to study flow stability and to analyze simulations and pulsers with voltage adders. The status of theory at this time allowed them to understand many features of these flows, but did not allow detailed analysis for design and data interpretation. Recent theoretical advances have drastically changed this situation. Two recent static models based on layered flows have allowed them to understand and to improve power coupling in voltage adders, current adders, plasma opening switches and in systems where the vacuum impedance varies along the flow. A dynamic model based upon electrons flowing in one or more thin layers has permitted detailed self-consistent time-dependent calculations which include electron flow. This model accurately predicts experimental and simulational data.

  5. Efficient hardware implementation of 3X for radix-8 encoding

    NASA Astrophysics Data System (ADS)

    Ruiz, G. A.; Granda, Mercedes

    2007-05-01

    Several commercial processors have selected the radix-8 multiplier architecture to increase their speed, thereby reducing the number of partial products. Radix-8 encoding reduces the digit number length in a signed digit representation. Its performance bottleneck is the generation of the term 3X, also referred to as hard multiple. This term is usually computed by an adding and shifting operation, 3X=2X+X, in a high-speed adder. In a 2X+X addition, close full adders share the same input signal. This property permits simplified algebraic expressions associated to a 3X operation other than in a conventional addition. This paper shows that the 3X operation can be expressed in terms of two signals, H i and K i, functionally equivalent to two carries. Hi and Ki are computed in parallel using architectures which lead to an area and speed efficient implementation. For the purposes of comparison, implementation based on standard-cells of conventional adders has been compared with the proposed circuits based on these H i and K i signals. As a result, the delay of proposed serial scheme is reduced by roughly 67% without additional cost in area, the delay and area of the carry look-ahead scheme is reduced by 20% and 17%, and that of the parallel prefix scheme is reduced by 26% and 46%, respectively.

  6. All-optical digital logic: Full addition or subtraction on a three-state system

    SciTech Connect

    Remacle, F.; Levine, R. D.

    2006-03-15

    Stimulated Raman adiabatic passage (STIRAP) is a well-studied pump-probe control scheme for manipulating the population of quantum states of atoms or molecules. By encoding the digits to be operated on as 'on' or 'off' laser input signals we show how STIRAP can be used to implement a finite-state logic machine. The physical conditions required for an effective STIRAP operation are related to the physical conditions expected for a logic machine. In particular, a condition is derived on the mean number of photons that represent an on pulse. A finite-state machine computes Boolean expressions that depend both on the input and on the present state of the machine. With two input signals we show how to implement a full adder where the carry-in digit is stored in the state of the machine. Furthermore, we show that it is possible to store the carry-out digit as the next state and thereby return the machine to a state ready for the next full addition. Such a machine operates as a cyclical full adder. We further show how this full adder can equally well be operated as a full subtractor. To the best of our knowledge this is the first example of a nanosized system that implements a full subtraction.

  7. Analytical formulas for the performance scaling of quantum processors with a large number of defective gates

    NASA Astrophysics Data System (ADS)

    Nam, Y. S.; Blümel, R.

    2015-10-01

    Removing a single logical gate from a classical information processor renders this processor useless. This is not so for a quantum information processor. A large number of quantum gates may be removed without significantly affecting the processor's performance. In this paper, focusing on the quantum Fourier transform (QFT) and quantum adder, we show even more: Even if most of its gates are eliminated and the remaining gates are selected from a randomly generated set, the QFT, one of the most useful quantum processors, and the quantum adder, one of the most basic building blocks of a universal quantum computer, still operate with satisfactory success probability, comparable to that of a quantum computer constructed with perfect gates. We support these conclusions by first laying out a general analytical framework and then deriving analytical scaling relations, which are in excellent agreement with our numerical simulations. The demonstrated robustness of the QFT and quantum adder, to the point where randomly generated quantum gates take the place of the exact gates, is an important boon for the construction of quantum computers, since it shows that stringent gate error tolerances do not have to be met to obtain satisfactory performance of the corresponding quantum processors. Our analytical techniques are powerful enough to generate asymptotic scaling laws for any gate defect model of quantum information processors and we illustrate this point by explicitly computing asymptotic analytical scaling formulas for several other defect models as well.

  8. Experimental study of particle-free mask handling

    NASA Astrophysics Data System (ADS)

    Amemiya, Mitsuaki; Ota, Kazuya; Taguchi, Takao; Suga, Osamu

    2009-03-01

    One of the critical issues for EUVL masks is clean and particle-free mask handling. We reported that the number of particle adders on the front side of a mask in the dual pod during the process from the load port to putting on the Electrostatic chuck (ESC) in vacuum could be reduce to less than 0.01 particle/cycle (>=46 nm). In addition, we found that chucking the mask on the ESC caused two serious issues. The first is that many particles stick to on the backside of the mask after chucking on the ESC, raising the question of whether the particle adders on the backside will travel to the front side. We examined the travel of these particles using the substrates after chucking and polystyrene latex (PSL) substrates that were dispersed on the backside. These experiments show that there is very little probability that particles on the backside will travel to the front side. The second issue is whether the mask blanks will charge up by chucking on the ESC and some particles will add on the front side. We measured the electric potential of the back and front sides of the mask and examined the particle adders. Our experiments revealed that to protect the mask from the particles, the mask must be grounded from the beginning to the end. For these two issues, we confirmed that a dual pod system works effectively to protect the mask from particles. This work is supported by NEDO as a part of the EUV mask program.

  9. Champions of profitable growth.

    PubMed

    Stewart, G Bennett

    2004-01-01

    Many companies have posted impressive top-line growth over the past two decades in their respective economic regions--for instance, Wal-Mart in North America, BP in Europe, Toyota in Asia, and News Corporation in the Southern Hemisphere. But which were the best at converting all of that revenue growth into shareholder value? Harvard Business Review asked C. Bennett Stewart III, the senior partner of the consulting firm Stern Stewart & Company, and his colleagues to come up with the answer. For the period 1983 to 2003, they assembled a list of the top 20 high-growth value adders (and laggards) in each of the four regions cited above. Their calculations gave equal weight to companies' revenue growth and market-value-added scores, revealing the important effect of region on the performance of companies in the same industry. For instance, while automakers are positioned high on the Asian list of high-growth value adders, U.S. carmakers GM and Ford--each of which reported revenue growth in excess of 100 billion dollars between 1983 and 2003--are among the value laggards on the North American list, as are DaimlerChrysler and Volkswagen on the European list. The Japanese win through better efficiency, higher quality, and narrower product mixes, the author says. And while there are four telecom companies represented among the European high-growth value adders, there are none on the North American list. That's probably because the European telecoms enjoyed more protective regulation, made fewer high-priced acquisitions, and didn't bet as big on the overblown dot-com economy, the author says. PMID:15241952

  10. Architecture Framework for Trapped-Ion Quantum Computer based on Performance Simulation Tool

    NASA Astrophysics Data System (ADS)

    Ahsan, Muhammad

    The challenge of building scalable quantum computer lies in striking appropriate balance between designing a reliable system architecture from large number of faulty computational resources and improving the physical quality of system components. The detailed investigation of performance variation with physics of the components and the system architecture requires adequate performance simulation tool. In this thesis we demonstrate a software tool capable of (1) mapping and scheduling the quantum circuit on a realistic quantum hardware architecture with physical resource constraints, (2) evaluating the performance metrics such as the execution time and the success probability of the algorithm execution, and (3) analyzing the constituents of these metrics and visualizing resource utilization to identify system components which crucially define the overall performance. Using this versatile tool, we explore vast design space for modular quantum computer architecture based on trapped ions. We find that while success probability is uniformly determined by the fidelity of physical quantum operation, the execution time is a function of system resources invested at various layers of design hierarchy. At physical level, the number of lasers performing quantum gates, impact the latency of the fault-tolerant circuit blocks execution. When these blocks are used to construct meaningful arithmetic circuit such as quantum adders, the number of ancilla qubits for complicated non-clifford gates and entanglement resources to establish long-distance communication channels, become major performance limiting factors. Next, in order to factorize large integers, these adders are assembled into modular exponentiation circuit comprising bulk of Shor's algorithm. At this stage, the overall scaling of resource-constraint performance with the size of problem, describes the effectiveness of chosen design. By matching the resource investment with the pace of advancement in hardware technology

  11. Serial multiplier arrays for parallel computation

    NASA Technical Reports Server (NTRS)

    Winters, Kel

    1990-01-01

    Arrays of systolic serial-parallel multiplier elements are proposed as an alternative to conventional SIMD mesh serial adder arrays for applications that are multiplication intensive and require few stored operands. The design and operation of a number of multiplier and array configurations featuring locality of connection, modularity, and regularity of structure are discussed. A design methodology combining top-down and bottom-up techniques is described to facilitate development of custom high-performance CMOS multiplier element arrays as well as rapid synthesis of simulation models and semicustom prototype CMOS components. Finally, a differential version of NORA dynamic circuits requiring a single-phase uncomplemented clock signal introduced for this application.

  12. Optical residue addition and storage units using a Hughes liquid crystal light valve

    NASA Technical Reports Server (NTRS)

    Habiby, S. F.; Collins, S. A., Jr.

    1984-01-01

    Optical addition and storage units are described in this paper. These units are implemented using the Hughes Liquid Crystal Light Valve (LCLV) as a spatial light modulator using residue arithmetic for a numerical representation. The main hardware components of the design, besides the light valve, include an array of single-mode optical fibers that provide input information, a polarizing prism in combination with quarter-wave and half-wave retarders for residue arithmetic implementation in the adder, and a holographic array for spatial stability in the storage unit.

  13. Optimizing EUV mask blank cleaning processes using the Lasertec M7360

    NASA Astrophysics Data System (ADS)

    Shimomura, Takeya; Kadaksham, Arun John; House, Matt; Ma, Andy; Goodwin, Frank

    2012-03-01

    EUV lithography is considered the most promising lithography solution for the 16 nm node and beyond. As EUV light is strongly absorbed by all known materials, reflective optics are used instead of conventional transmittance optics applied to ArF and KrF lithography. The EUV mask must also need be reflective. It typically consists of a Ta-based absorber layer, Ru capping layer, Si/Mo multilayer on a low thermal expansion material (LTEM) substrate with a backside Cr-based metal coating. Because of the strong absorbance of the EUV light, a pellicle is not practical. Therefore, EUV masks must be cleaned more frequently to maintain the necessary cleanliness. This poses numerous unique challenges in cleaning processes. For example, the EUV mask integrity, including critical dimension (CD), EUV reflectivity, and absorber thickness must be kept intact during multiple cleanings throughout the mask's lifetime. Requirements of defect size for the cleaning, furthermore, are becoming tighter as semiconductor circuit design rules get smaller. According to the International Technology Roadmap For Semiconductors (ITRS), the smallest defect size that must be removed is 23 nm for the 18 nm NAND Flash node in 2013. In addition to defects on the frontside, defects on a backside also need to be minimized since they might lead overlay error due to local distortions of EUV masks on an electrostatic chuck. This paper focuses on evaluations of cleaning performances using the Lasertec M1350 and M7360 blank inspection system, which has a 71 nm and 43 nm sensitivity. The 43nm is the current best sensitivity while keeping a >90% defect capture rate. First, the cleaning performance using the standard process has been investigated. We found a mitigation of adders was a key challenge for the EUV mask cleaning. The primary source of the adders was also identified as pits. Secondly, the megasonic cleaning process has been optimized to mitigate the adders. We could successfully reduce the adders by

  14. Techniques for Computing the DFT Using the Residue Fermat Number Systems and VLSI

    NASA Technical Reports Server (NTRS)

    Truong, T. K.; Chang, J. J.; Hsu, I. S.; Pei, D. Y.; Reed, I. S.

    1985-01-01

    The integer complex multiplier and adder over the direct sum of two copies of a finite field is specialized to the direct sum of the rings of integers modulo Fermat numbers. Such multiplications and additions can be used in the implementation of a discrete Fourier transform (DFT) of a sequence of complex numbers. The advantage of the present approach is that the number of multiplications needed for the DFT can be reduced substantially over the previous approach. The architectural designs using this approach are regular, simple, expandable and, therefore, naturally suitable for VLSI implementation.

  15. A Solid-State Modulator for High Speed Kickers

    SciTech Connect

    Watson, J A; Cook, E G; Chen, Y J; Anaya, R M; Lee, B S; Sullivan, J S; Hawkins, S A; Allen, F V; Hickman, B C; Brooksby, C A

    2001-06-11

    An all solid-state modulator with multi-pulse burst capability, very fast rise and fall times, pulse width agility, and amplitude modulation capability for use with high-speed beam kickers has been designed and tested at LLNL. The modulator uses multiple solid-state modules stacked in an inductive-adder configuration. It provides a nominal 18kV pulse with {+-} 10% amplitude modulation on the order of several MHz, rise times on the order of 10nS, and can be configured for either positive or negative polarity. The presentation will include measured performance data.

  16. Solid-State Modulators for RF And Fast Kickers

    SciTech Connect

    Cook, E.G.; Akana, G.L.; Gower, E.J.; Hawkins, S.A.; Hickman, B.C.; Brooksby, C.A.; Cassel, R.L.; de Lamare, J.E.; Nguyen, M.N.; Pappas, G.C.; /SLAC

    2006-03-14

    As the switching capabilities of solid-state devices increase, these devices are being incorporated into modulator designs for high voltage accelerator applications. Solid-state modulators based on inductive adder circuit topology have demonstrated great versatility with regard to pulse width and pulse repetition rate while maintaining fast pulse rise and fall times. Additionally, these modulators are capable of being scaled to higher output voltage and power levels. An explanation of the basic circuit operation will be presented as well as test data of several different hardware systems.

  17. Universal programmable logic gate and routing method

    NASA Technical Reports Server (NTRS)

    Fijany, Amir (Inventor); Vatan, Farrokh (Inventor); Akarvardar, Kerem (Inventor); Blalock, Benjamin (Inventor); Chen, Suheng (Inventor); Cristoloveanu, Sorin (Inventor); Kolawa, Elzbieta (Inventor); Mojarradi, Mohammad M. (Inventor); Toomarian, Nikzad (Inventor)

    2009-01-01

    An universal and programmable logic gate based on G.sup.4-FET technology is disclosed, leading to the design of more efficient logic circuits. A new full adder design based on the G.sup.4-FET is also presented. The G.sup.4-FET can also function as a unique router device offering coplanar crossing of signal paths that are isolated and perpendicular to one another. This has the potential of overcoming major limitations in VLSI design where complex interconnection schemes have become increasingly problematic.

  18. 20 GHz Operation of an Asynchronous Wave-Pipelined RSFQ Arithmetic-Logic Unit

    NASA Astrophysics Data System (ADS)

    Filippov, Timur V.; Sahu, Anubhav; Kirichenko, Alex F.; Vernik, Igor V.; Dorojevets, Mikhail; Ayala, Christopher L.; Mukhanov, Oleg A.

    We have designed and tested at high frequency an RSFQ-based Arithmetic-Logic Unit (ALU), the critical component of an 8-bit RSFQ processor datapath. The ALU design is based on a Kogge-Stone adder and employs an asynchronous wave-pipelined approach scalable for wide datapath processors. The 8-bit ALU circuit was fabricated with HYPRES' standard 4.5 kA/cm2 process and consists of 7,950 Josephson junctions, including input and output interfaces. In this paper, we present chip design and high-speed test results for the 8-bit ALU circuit.

  19. The high current, fast, 100ns, Linear Transformer Driver (LTD) developmental project at Sandia Laboratories and HCEI.

    SciTech Connect

    Ward, Kevin S.; Long, Finis W.; Sinebryukhov, Vadim A. , Tomsk, Russia); Kim, Alexandre A. , Tomsk, Russia); Wakeland, Peter Eric; McKee, G. Randall; Woodworth, Joseph Ray; McDaniel, Dillon Heirman; Fowler, William E.; Mazarakis, Michael Gerrassimos; Porter, John Larry, Jr.; Struve, Kenneth William; Savage, Mark Edward; Stygar, William A.; LeChien, Keith R.; Matzen, Maurice Keith

    2010-09-01

    Sandia National Laboratories, Albuquerque, N.M., USA, in collaboration with the High Current Electronic Institute (HCEI), Tomsk, Russia, is developing a new paradigm in pulsed power technology: the Linear Transformer Driver (LTD) technology. This technological approach can provide very compact devices that can deliver very fast high current and high voltage pulses straight out of the cavity with out any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The load may be a vacuum electron diode, a z-pinch wire array, a gas puff, a liner, an isentropic compression load (ICE) to study material behavior under very high magnetic fields, or a fusion energy (IFE) target. This is because the output pulse rise time and width can be easily tailored to the specific application needs. In this paper we briefly summarize the developmental work done in Sandia and HCEI during the last few years, and describe our new MYKONOS Sandia High Current LTD Laboratory. An extensive evaluation of the LTD technology is being performed at SNL and the High Current Electronic Institute (HCEI) in Tomsk Russia. Two types of High Current LTD cavities (LTD I-II, and 1-MA LTD) were constructed and tested individually and in a voltage adder configuration (1-MA cavity only). All cavities performed remarkably well and the experimental results are in full agreement with analytical and numerical calculation predictions. A two-cavity voltage adder is been assembled and currently undergoes evaluation. This is the first step towards the completion of the 10-cavity, 1-TW module. This MYKONOS voltage adder will be the first ever IVA built with a transmission line insulated with deionized water. The LTD II cavity renamed LTD III will serve as a test bed for evaluating a number of different types of switches, resistors, alternative capacitor configurations, cores

  20. Balanced ternary addition using a gated silicon nanowire

    NASA Astrophysics Data System (ADS)

    Mol, J. A.; van der Heijden, J.; Verduijn, J.; Klein, M.; Remacle, F.; Rogge, S.

    2011-12-01

    Ternary logic has the lowest cost of complexity, here, we demonstrate a CMOS hardware implementation of a ternary adder using a silicon metal-on-insulator single electron transistor. Gate dependent rectifying behavior of a single electron transistor (SET) results in a robust three-valued output as a function of the potential of the single electron transistor island. Mapping logical, ternary inputs to the three gates controlling the potential of the single electron transistor island allows us to perform complex, inherently ternary operations, on a single transistor.

  1. Massively parallel spatial light modulation-based optical signal processing

    NASA Astrophysics Data System (ADS)

    Li, Yao

    1993-03-01

    A new optical parallel arithmetic processing scheme using a nonholographic optoelectronic content-addressable memory (CAM) was proposed. The design of a four-bit CAM-based optical carry look-ahead adder was studied. Compared with existing optoelectronic binary addition approaches, this nonholographic CAM Scheme offers a number of practical advantages, such as faster processing speed and ease of optical implementation and alignment. For an addition of numbers longer than four bits, by incorporating the previous stage's carry, a number of four-bit CLA's can be cascaded. Experimental results were also demonstrated. One paper to the Optics Letters was published.

  2. Evaluation of floating-point sum or difference of products in carry-save domain

    NASA Technical Reports Server (NTRS)

    Wahab, A.; Erdogan, S.; Premkumar, A. B.

    1992-01-01

    An architecture to evaluate a 24-bit floating-point sum or difference of products using modified sequential carry-save multipliers with extensive pipelining is described. The basic building block of the architecture is a carry-save multiplier with built-in mantissa alignment for the summation during the multiplication cycles. A carry-save adder, capable of mantissa alignment, correctly positions products with the current carry-save sum. Carry propagation in individual multipliers is avoided and is only required once to produce the final result.

  3. VLSI Reed-Solomon Encoder With Interleaver

    NASA Technical Reports Server (NTRS)

    Hsu, In-Shek; Deutsch, L. J.; Truong, Trieu-Kie; Reed, I. S.

    1990-01-01

    Size, weight, and susceptibility to burst errors reduced. Encoding system built on single very-large-scale integrated (VLSI) circuit chip produces (255,223) Reed-Solomon (RS) code with programmable interleaving up to depth of 5. (225,223) RS encoder includes new remainder-and-interleaver unit providing programmable interleaving of code words. Remainder-and-interleaver unit contains shift registers and modulo-2 adders. Signals on "turn" and "no-turn" lines control depth of interleaving. Based on E. R. Berlekamp's bit-serial multiplication algorithm for (225,223) RS encoder over Galois Field (2 to the 8th power).

  4. Computing with liquid crystal fingers: models of geometric and logical computation.

    PubMed

    Adamatzky, Andrew; Kitson, Stephen; Costello, Ben De Lacy; Matranga, Mario Ariosto; Younger, Daniel

    2011-12-01

    When a voltage is applied across a thin layer of cholesteric liquid crystal, fingers of cholesteric alignment can form and propagate in the layer. In computer simulation, based on experimental laboratory results, we demonstrate that these cholesteric fingers can solve selected problems of computational geometry, logic, and arithmetics. We show that branching fingers approximate a planar Voronoi diagram, and nonbranching fingers produce a convex subdivision of concave polygons. We also provide a detailed blueprint and simulation of a one-bit half-adder functioning on the principles of collision-based computing, where the implementation is via collision of liquid crystal fingers with obstacles and other fingers. PMID:22304104

  5. [Attempted suicide by snake bite. Case report and literature survey].

    PubMed

    Strubel, T; Birkhofer, A; Eyer, F; Werber, K D; Förstl, H

    2008-05-01

    Unusual suicide attempts often remain undetected, and bizarre methods can be a clue to psychotic origin. We report a suicide attempt by proxy--the bite of a puff adder--and provide a brief literature survey about further archaic self-injurious behaviour. Due to the easy availability of venomous snakes and the close networking of suicidal patients via the Internet, an increase in similar cases can be anticipated. A failed suicide attempt should always be considered in patients surviving bizarre accidents. PMID:18365165

  6. Energy-Efficient Wide Datapath Integer Arithmetic Logic Units Using Superconductor Logic

    NASA Astrophysics Data System (ADS)

    Ayala, Christopher Lawrence

    Complementary Metal-Oxide-Semiconductor (CMOS) technology is currently the most widely used integrated circuit technology today. As CMOS approaches the physical limitations of scaling, it is unclear whether or not it can provide long-term support for niche areas such as high-performance computing and telecommunication infrastructure, particularly with the emergence of cloud computing. Alternatively, superconductor technologies based on Josephson junction (JJ) switching elements such as Rapid Single Flux Quantum (RSFQ) logic and especially its new variant, Energy-Efficient Rapid Single Flux Quantum (ERSFQ) logic have the capability to provide an ultra-high-speed, low power platform for digital systems. The objective of this research is to design and evaluate energy-efficient, high-speed 32-bit integer Arithmetic Logic Units (ALUs) implemented using RSFQ and ERSFQ logic as the first steps towards achieving practical Very-Large-Scale-Integration (VLSI) complexity in digital superconductor electronics. First, a tunable VHDL superconductor cell library is created to provide a mechanism to conduct design exploration and evaluation of superconductor digital circuits from the perspectives of functionality, complexity, performance, and energy-efficiency. Second, hybrid wave-pipelining techniques developed earlier for wide datapath RSFQ designs have been used for efficient arithmetic and logic circuit implementations. To develop the core foundation of the ALU, the ripple-carry adder and the Kogge-Stone parallel prefix carry look-ahead adder are studied as representative candidates on opposite ends of the design spectrum. By combining the high-performance features of the Kogge-Stone structure and the low complexity of the ripple-carry adder, a 32-bit asynchronous wave-pipelined hybrid sparse-tree ALU has been designed and evaluated using the VHDL cell library tuned to HYPRES' gate-level characteristics. The designs and techniques from this research have been implemented using

  7. Effects of snake envenomation: a guide for emergency nurses.

    PubMed

    McGhee, Stephen; Finnegan, Alan; Clochesy, John M; Visovsky, Constance

    2015-02-01

    Only one species of venomous snake, the adder, is indigenous to the UK, but many people keep venomous snakes as pets and others travel to places, such as the United States, where a wider variety of venomous snakes can be found. Emergency nurses should therefore be prepared to treat bite wounds caused by venomous and non-venomous snakes. This article offers an overview of the most common forms of envenomation in the UK and makes recommendations for the clinical care of people who have sustained snake bites. PMID:25659795

  8. Hemispheric Imaging of Galactic Neutral Hydrogen with a Phased Array Antenna System

    NASA Astrophysics Data System (ADS)

    Wijnholds, Stefan J.; De Bruyn, A. Ger; Bregman, Jaap D.; Bij De Vaate, Jan Geralt

    2004-06-01

    The thousand element array (THEA) system is a phased array system consisting of 1 m2 tiles having 64 Vivaldi elements each, arranged on a regular 8-by-8 grid, which has been developed as a demonstrator of technology and applicability for SKA. In this paper we present imaging results of Galactic neutral hydrogen with THEA. Measurements have been taken using a dense 2-by-2 array of four tiles as a four tile adder. The results are compared with results from the Leiden-Dwingeloo Survey, showing qualitative agreement, but also indicating that further studies are needed on the instrumental characteristics.

  9. Compact modeling of perpendicular nanomagnetic logic based on threshold gates

    NASA Astrophysics Data System (ADS)

    Breitkreutz, Stephan; Eichwald, Irina; Kiermaier, Josef; Csaba, Gyorgy; Schmitt-Landsiedel, Doris; Becherer, Markus

    2014-05-01

    In this work, we show that physical-based compact modeling of perpendicular Nanomagnetic Logic is crucial for the design and simulation of complex circuitry. A compact model for field-coupled nanomagnets based on an Arrhenius switching model and finite element calculations is introduced. As physical parameters have an enormous influence on the behavior of the circuit, their modeling is of great importance. Exemplarily, a 1-bit full adder based on threshold logic gates is analyzed due to its reliability. The obtained findings are used to design a pure magnetic arithmetic logic unit, which can be used for basic Boolean and logic operations.

  10. Smart molecules at work--mimicking advanced logic operations.

    PubMed

    Andréasson, Joakim; Pischel, Uwe

    2010-01-01

    Molecular logic is an interdisciplinary research field, which has captured worldwide interest. This tutorial review gives a brief introduction into molecular logic and Boolean algebra. This serves as the basis for a discussion of the state-of-the-art and future challenges in the field. Representative examples from the most recent literature including adders/subtractors, multiplexers/demultiplexers, encoders/decoders, and sequential logic devices (keypad locks) are highlighted. Other horizons, such as the utility of molecular logic in bio-related applications, are discussed as well. PMID:20023848

  11. Reconfigurable and resettable arithmetic logic units based on magnetic beads and DNA

    NASA Astrophysics Data System (ADS)

    Zhang, Siqi; Wang, Kun; Huang, Congcong; Sun, Ting

    2015-12-01

    Based on the characteristics of magnetic beads and DNA, a simple and universal platform was developed for the integration of multiple logic gates to achieve resettable half adder and half subtractor functions. The signal reporter was composed of a split G-quadruplex DNAzyme and AuNP-surface immobilized molecular beacon molecule. The novel feature of the designed system is that the inputs (split G-quadruplexes) can interact with hairpin-modified Au NPs linked to magnetic particles. Another novel feature is that the logic operations can be reset by heating the output system and by using the magnetic separation of the computing modules. Moreover, the developed half adder and half subtractor are realized on a simple DNA/magnetic bead platform in an enzyme-free system and share a constant threshold setpoint. Due to the diversity and design flexibility of DNA, these investigations may provide a new method for the development of resettable DNA-based arithmetic operations.Based on the characteristics of magnetic beads and DNA, a simple and universal platform was developed for the integration of multiple logic gates to achieve resettable half adder and half subtractor functions. The signal reporter was composed of a split G-quadruplex DNAzyme and AuNP-surface immobilized molecular beacon molecule. The novel feature of the designed system is that the inputs (split G-quadruplexes) can interact with hairpin-modified Au NPs linked to magnetic particles. Another novel feature is that the logic operations can be reset by heating the output system and by using the magnetic separation of the computing modules. Moreover, the developed half adder and half subtractor are realized on a simple DNA/magnetic bead platform in an enzyme-free system and share a constant threshold setpoint. Due to the diversity and design flexibility of DNA, these investigations may provide a new method for the development of resettable DNA-based arithmetic operations. Electronic supplementary information

  12. Initial results from the unipolar operation of the RHEPP module

    SciTech Connect

    Harjes, H.C.; Penn, K.J.; Reed, K.W.; McClenahan, C.R.; Laderach, G.E.; Wavrik, R.W.; Adcock, J.L.; Butler, M.E.; Mann, G.A.; Pena, G.E.; Weber, G.J.; VanDeValde, D.; Martinez, L.E.; Muirhead, D.; Kiekel, P.D.; Johnson, D.L.; Neau, E.L.

    1992-08-01

    Several potential applications such as medical waste treatment, chemical waste treatment, food treatment, and flue gas cleanup have been identified for high average power electron beam systems. The technology for such a system is being developed in the RHEPP (Repetitive High Energy Pulsed Power) project. The RHEPP module consists of a multistage magnetic pulse compressor driving a linear induction voltage adder with an e-beam diode load. It has been designed to operate continuously, delivering 350 kW of average power to the diode in 60-ns FWHM, 2.5-MV, 2.9-kJ pulses. The module is presently under construction with the first phase scheduled for completion in the summer of 1992. In the first phase, four of ten adder stages are being built so that testing can begin with a I-MV, 160-kW diode with the balance of the power from the compressor diverted to a resistive load. A description of the system and test results from the initial stages of the compressor will be presented.

  13. Initial results from the unipolar operation of the RHEPP module

    SciTech Connect

    Harjes, H.C.; Penn, K.J.; Reed, K.W.; McClenahan, C.R.; Laderach, G.E.; Wavrik, R.W.; Adcock, J.L.; Butler, M.E.; Mann, G.A.; Pena, G.E.; Weber, G.J.; VanDeValde, D.; Martinez, L.E.; Muirhead, D.; Kiekel, P.D.; Johnson, D.L.; Neau, E.L.

    1992-01-01

    Several potential applications such as medical waste treatment, chemical waste treatment, food treatment, and flue gas cleanup have been identified for high average power electron beam systems. The technology for such a system is being developed in the RHEPP (Repetitive High Energy Pulsed Power) project. The RHEPP module consists of a multistage magnetic pulse compressor driving a linear induction voltage adder with an e-beam diode load. It has been designed to operate continuously, delivering 350 kW of average power to the diode in 60-ns FWHM, 2.5-MV, 2.9-kJ pulses. The module is presently under construction with the first phase scheduled for completion in the summer of 1992. In the first phase, four of ten adder stages are being built so that testing can begin with a I-MV, 160-kW diode with the balance of the power from the compressor diverted to a resistive load. A description of the system and test results from the initial stages of the compressor will be presented.

  14. The Probabilistic Convolution Tree: Efficient Exact Bayesian Inference for Faster LC-MS/MS Protein Inference

    PubMed Central

    Serang, Oliver

    2014-01-01

    Exact Bayesian inference can sometimes be performed efficiently for special cases where a function has commutative and associative symmetry of its inputs (called “causal independence”). For this reason, it is desirable to exploit such symmetry on big data sets. Here we present a method to exploit a general form of this symmetry on probabilistic adder nodes by transforming those probabilistic adder nodes into a probabilistic convolution tree with which dynamic programming computes exact probabilities. A substantial speedup is demonstrated using an illustration example that can arise when identifying splice forms with bottom-up mass spectrometry-based proteomics. On this example, even state-of-the-art exact inference algorithms require a runtime more than exponential in the number of splice forms considered. By using the probabilistic convolution tree, we reduce the runtime to and the space to where is the number of variables joined by an additive or cardinal operator. This approach, which can also be used with junction tree inference, is applicable to graphs with arbitrary dependency on counting variables or cardinalities and can be used on diverse problems and fields like forward error correcting codes, elemental decomposition, and spectral demixing. The approach also trivially generalizes to multiple dimensions. PMID:24626234

  15. Dual Brushless Resolver Rate Sensor

    NASA Technical Reports Server (NTRS)

    Howard, David E. (Inventor)

    1997-01-01

    A resolver rate sensor is disclosed in which dual brushless resolvers are mechanically coupled to the same output shaft. Diverse inputs are provided to each resolver by providing the first resolver with a DC input and the second resolver with an AC sinusoidal input. A trigonometric identity in which the sum of the squares of the sin and cosine components equal one is used to advantage in providing a sensor of increased accuracy. The first resolver may have a fixed or variable DC input to permit dynamic adjustment of resolver sensitivity thus permitting a wide range of coverage. In one embodiment of the invention the outputs of the first resolver are directly inputted into two separate multipliers and the outputs of the second resolver are inputted into the two separate multipliers, after being demodulated in a pair of demodulator circuits. The multiplied signals are then added in an adder circuit to provide a directional sensitive output. In another embodiment the outputs from the first resolver is modulated in separate modulator circuits and the output from the modulator circuits are used to excite the second resolver. The outputs from the second resolver are demodulated in separate demodulator circuit and added in an adder circuit to provide a direction sensitive rate output.

  16. Automatic oscillator frequency control system

    NASA Technical Reports Server (NTRS)

    Smith, S. F. (Inventor)

    1985-01-01

    A frequency control system makes an initial correction of the frequency of its own timing circuit after comparison against a frequency of known accuracy and then sequentially checks and corrects the frequencies of several voltage controlled local oscillator circuits. The timing circuit initiates the machine cycles of a central processing unit which applies a frequency index to an input register in a modulo-sum frequency divider stage and enables a multiplexer to clock an accumulator register in the divider stage with a cyclical signal derived from the oscillator circuit being checked. Upon expiration of the interval, the processing unit compares the remainder held as the contents of the accumulator against a stored zero error constant and applies an appropriate correction word to a correction stage to shift the frequency of the oscillator being checked. A signal from the accumulator register may be used to drive a phase plane ROM and, with periodic shifts in the applied frequency index, to provide frequency shift keying of the resultant output signal. Interposition of a phase adder between the accumulator register and phase plane ROM permits phase shift keying of the output signal by periodic variation in the value of a phase index applied to one input of the phase adder.

  17. A mechanistic stochastic framework for regulating bacterial cell division

    PubMed Central

    Ghusinga, Khem Raj; Vargas-Garcia, Cesar A.; Singh, Abhyudai

    2016-01-01

    How exponentially growing cells maintain size homeostasis is an important fundamental problem. Recent single-cell studies in prokaryotes have uncovered the adder principle, where cells add a fixed size (volume) from birth to division, irrespective of their size at birth. To mechanistically explain the adder principle, we consider a timekeeper protein that begins to get stochastically expressed after cell birth at a rate proportional to the volume. Cell-division time is formulated as the first-passage time for protein copy numbers to hit a fixed threshold. Consistent with data, the model predicts that the noise in division timing increases with size at birth. Intriguingly, our results show that the distribution of the volume added between successive cell-division events is independent of the newborn cell size. This was dramatically seen in experimental studies, where histograms of the added volume corresponding to different newborn sizes collapsed on top of each other. The model provides further insights consistent with experimental observations: the distribution of the added volume when scaled by its mean becomes invariant of the growth rate. In summary, our simple yet elegant model explains key experimental findings and suggests a mechanism for regulating both the mean and fluctuations in cell-division timing for controlling size. PMID:27456660

  18. Scalability of carbon-nanotube-based thin film transistors for flexible electronic devices manufactured using an all roll-to-roll gravure printing system

    PubMed Central

    Koo, Hyunmo; Lee, Wookyu; Choi, Younchang; Sun, Junfeng; Bak, Jina; Noh, Jinsoo; Subramanian, Vivek; Azuma, Yasuo; Majima, Yutaka; Cho, Gyoujin

    2015-01-01

    To demonstrate that roll-to-roll (R2R) gravure printing is a suitable advanced manufacturing method for flexible thin film transistor (TFT)-based electronic circuits, three different nanomaterial-based inks (silver nanoparticles, BaTiO3 nanoparticles and single-walled carbon nanotubes (SWNTs)) were selected and optimized to enable the realization of fully printed SWNT-based TFTs (SWNT-TFTs) on 150-m-long rolls of 0.25-m-wide poly(ethylene terephthalate) (PET). SWNT-TFTs with 5 different channel lengths, namely, 30, 80, 130, 180, and 230 μm, were fabricated using a printing speed of 8 m/min. These SWNT-TFTs were characterized, and the obtained electrical parameters were related to major mechanical factors such as web tension, registration accuracy, impression roll pressure and printing speed to determine whether these mechanical factors were the sources of the observed device-to-device variations. By utilizing the electrical parameters from the SWNT-TFTs, a Monte Carlo simulation for a 1-bit adder circuit, as a reference, was conducted to demonstrate that functional circuits with reasonable complexity can indeed be manufactured using R2R gravure printing. The simulation results suggest that circuits with complexity, similar to the full adder circuit, can be printed with a 76% circuit yield if threshold voltage (Vth) variations of less than 30% can be maintained. PMID:26411839

  19. Scalability of carbon-nanotube-based thin film transistors for flexible electronic devices manufactured using an all roll-to-roll gravure printing system

    NASA Astrophysics Data System (ADS)

    Koo, Hyunmo; Lee, Wookyu; Choi, Younchang; Sun, Junfeng; Bak, Jina; Noh, Jinsoo; Subramanian, Vivek; Azuma, Yasuo; Majima, Yutaka; Cho, Gyoujin

    2015-09-01

    To demonstrate that roll-to-roll (R2R) gravure printing is a suitable advanced manufacturing method for flexible thin film transistor (TFT)-based electronic circuits, three different nanomaterial-based inks (silver nanoparticles, BaTiO3 nanoparticles and single-walled carbon nanotubes (SWNTs)) were selected and optimized to enable the realization of fully printed SWNT-based TFTs (SWNT-TFTs) on 150-m-long rolls of 0.25-m-wide poly(ethylene terephthalate) (PET). SWNT-TFTs with 5 different channel lengths, namely, 30, 80, 130, 180, and 230 μm, were fabricated using a printing speed of 8 m/min. These SWNT-TFTs were characterized, and the obtained electrical parameters were related to major mechanical factors such as web tension, registration accuracy, impression roll pressure and printing speed to determine whether these mechanical factors were the sources of the observed device-to-device variations. By utilizing the electrical parameters from the SWNT-TFTs, a Monte Carlo simulation for a 1-bit adder circuit, as a reference, was conducted to demonstrate that functional circuits with reasonable complexity can indeed be manufactured using R2R gravure printing. The simulation results suggest that circuits with complexity, similar to the full adder circuit, can be printed with a 76% circuit yield if threshold voltage (Vth) variations of less than 30% can be maintained.

  20. Scalability of carbon-nanotube-based thin film transistors for flexible electronic devices manufactured using an all roll-to-roll gravure printing system.

    PubMed

    Koo, Hyunmo; Lee, Wookyu; Choi, Younchang; Sun, Junfeng; Bak, Jina; Noh, Jinsoo; Subramanian, Vivek; Azuma, Yasuo; Majima, Yutaka; Cho, Gyoujin

    2015-01-01

    To demonstrate that roll-to-roll (R2R) gravure printing is a suitable advanced manufacturing method for flexible thin film transistor (TFT)-based electronic circuits, three different nanomaterial-based inks (silver nanoparticles, BaTiO3 nanoparticles and single-walled carbon nanotubes (SWNTs)) were selected and optimized to enable the realization of fully printed SWNT-based TFTs (SWNT-TFTs) on 150-m-long rolls of 0.25-m-wide poly(ethylene terephthalate) (PET). SWNT-TFTs with 5 different channel lengths, namely, 30, 80, 130, 180, and 230 μm, were fabricated using a printing speed of 8 m/min. These SWNT-TFTs were characterized, and the obtained electrical parameters were related to major mechanical factors such as web tension, registration accuracy, impression roll pressure and printing speed to determine whether these mechanical factors were the sources of the observed device-to-device variations. By utilizing the electrical parameters from the SWNT-TFTs, a Monte Carlo simulation for a 1-bit adder circuit, as a reference, was conducted to demonstrate that functional circuits with reasonable complexity can indeed be manufactured using R2R gravure printing. The simulation results suggest that circuits with complexity, similar to the full adder circuit, can be printed with a 76% circuit yield if threshold voltage (Vth) variations of less than 30% can be maintained. PMID:26411839

  1. High current, 0.5-MA, fast, 100-ns, linear transformer driver experiments

    NASA Astrophysics Data System (ADS)

    Mazarakis, Michael G.; Fowler, William E.; Kim, Alexander A.; Sinebryukhov, Vadim A.; Rogowski, Sonrisa T.; Sharpe, Robin A.; McDaniel, Dillon H.; Olson, Craig L.; Porter, John L.; Struve, Kenneth W.; Stygar, William A.; Woodworth, Joseph R.

    2009-05-01

    The linear transformer driver (LTD) is a new method for constructing high current, high-voltage pulsed accelerators. The salient feature of the approach is switching and inductively adding the pulses at low voltage straight out of the capacitors through low inductance transfer and soft iron core isolation. Sandia National Laboratories are actively pursuing the development of a new class of accelerator based on the LTD technology. Presently, the high current LTD experimental research is concentrated on two aspects: first, to study the repetition rate capabilities, reliability, reproducibility of the output pulses, switch prefires, jitter, electrical power and energy efficiency, and lifetime measurements of the cavity active components; second, to study how a multicavity linear array performs in a voltage adder configuration relative to current transmission, energy and power addition, and wall plug to output pulse electrical efficiency. Here we report the repetition rate and lifetime studies performed in the Sandia High Current LTD Laboratory. We first utilized the prototype ˜0.4-MA, LTD I cavity which could be reliably operated up to ±90-kV capacitor charging. Later we obtained an improved 0.5-MA, LTD II version that can be operated at ±100kV maximum charging voltage. The experimental results presented here were obtained with both cavities and pertain to evaluating the maximum achievable repetition rate and LTD cavity performance. The voltage adder experiments with a series of double sized cavities (1 MA, ±100kV) will be reported in future publications.

  2. High-speed transcendental elementary-function architecture in support of the Vector Wave Equation (VWE). Master's thesis

    SciTech Connect

    Bailey, M.J.

    1987-12-01

    In support of a Very High Speed Integrated Circuit (VHSIC) class processor for computation of a set of equations known as the Vector Wave Equations (VWE), certain elementary functions including sine, cosine, and division are required. These elementary functions are the bottlenecks in the VWE processor. Floating-point multipliers and adders comprise the remainder of the pipeline stages in the VWE processor. To speed up the computation of the elementary functions, pipelining within the functions is considered. To compute sine, cosine, and division, the CORDIC algorithm is presented. Another method for computation of sine and cosine is the expansion of the Chebyshev polynomials. The equations for the CORDIC processor are recursive and the resulting hardware is very simple, consisting of three adders, three shifters, and lookup table for some of the coefficients. The shifters replace the multiplies, because in binary, i right shifts is the same as multiplying by 2 to the 8th power. The expansion of the Chebyshev polynomials can be used to compute other trigonometric functions as well as the exponential and logarithmic functions. The expansion of the Chebyshev polynomials can be used as a mathematic coprocessor. From these equations, a pipelined architecture can be realized that results in very fast computation times. The transformation of these equations as a function of x instead of the Chebyshev polynomials produces an architecture that requires less hardware, resulting in even faster computation times.

  3. Power flow in long MITLs with high-inductance loads

    SciTech Connect

    Poukey, J.W.; Mazarkis, M.G.

    1994-12-31

    The authors are using the 2-D TWOQUICK simulation code to study a system consisting of a voltage adder, a long magnetically-insulated transmission line (MITL), and a large-inductance load which includes a conducting foil (short circuit). The object of this work is to produce a voltage pulse of typically 10 MV and several hundred ns which travels down a MITL of about 10 meters length and 5--10 ohms vacuum impedance, and then couples efficiently to a load of a few hundred nH inductance. They discuss modeling issues such as the use of simple transmission lines for parts of the system, and methods for representing the load. Important physics issues include voltage-pulse erosion in long MITLs, effects of reflected waves from the highly overmatched load impedance, and energy fraction delivered to the load. They calculate electron losses in all parts of the system. Parameter variations of interest include input voltage waveform, adder geometry, MITL length and impedance, and loaded configuration and inductance. Comparisons with circuit models (SCREAMER) will be shown.

  4. Structure of High-Speed Modulo Multiplier Suitable for Repeated Operations

    NASA Astrophysics Data System (ADS)

    Kudou, Tadamichi; Tsunekawa, Yoshitaka; Suzuki, Masayuki

    In this paper, we propose a new modulo multiplier suitable for repeated operations using redundant representations. First, we consider a computation rule for radix-2 modulo multiplications. In radix-2 operation, we show two methods to calculate (2i-1 mod n) from (2i mod n) and decide product digits sequentially from upper side. These methods make it possible to perform (2i-1 mod n) and multiplications simultaneously. Second, we attempt to apply these methods to radix-4 operations which enables us to reduce clock cycles by only shift and sign change. We propose some structures to perform each part efficiently for radix-4 modulo multiplications. The high-speed redundant binary adder/subtractor which we have already proposed is applied to these structures. By using this adder/subtractor, the longest delay path of this modulo multiplier becomes very short. Finally, by using PARTHENON which is a design system for VLSI, this modulo multiplier is designed and evaluated. As a result, we show the speed of this proposed modulo multiplier becomes over 2.5 times as compared with the conventional structures.

  5. Implementation and modeling of parametrizable high-speed Reed Solomon decoders on FPGAs

    NASA Astrophysics Data System (ADS)

    Flocke, A.; Blume, H.; Noll, T. G.

    2005-05-01

    One of the most important error correction codes in digital signal processing is the Reed Solomon code. A lot of VLSI implementations have been described in literature. This paper introduces a highly parametrizable RS-decoder for FPGAs. By implementing resource-sharing and by using a fully pipelined multiplier/adder-unit in GF(2m) it was possible to achieve high throughput rates up to 1.3Gbit/s on a standard FPGA, while using only an attractive small amount of logical elements (LE). The implementation, written in a hardware description language (HDL), is based on an inversionless Berlekamp Algorithm (iBA), whose structure leads to a chain of identical processing elements (PE). The critical path of one PE runs only through one adder and one multiplier. A detailed description of a resource-sharing methodology for this Berlekamp Algorithm and the achievable gain are presented in this paper. The benchmarking for the design was done for different 8bit-codes against state-of-the-art FPGA-solutions and showed a gain of up to a factor of six regarding the AT-product, compared to other implementations.

  6. Detector for flow abnormalities in gaseous diffusion plant compressors

    DOEpatents

    Smith, Stephen F.; Castleberry, Kim N.

    1998-01-01

    A detector detects a flow abnormality in a plant compressor which outputs a motor current signal. The detector includes a demodulator/lowpass filter demodulating and filtering the motor current signal producing a demodulated signal, and first, second, third and fourth bandpass filters connected to the demodulator/lowpass filter, and filtering the demodulated signal in accordance with first, second, third and fourth bandpass frequencies generating first, second, third and fourth filtered signals having first, second, third and fourth amplitudes. The detector also includes first, second, third and fourth amplitude detectors connected to the first, second, third and fourth bandpass filters respectively, and detecting the first, second, third and fourth amplitudes, and first and second adders connected to the first and fourth amplitude detectors and the second and third amplitude detectors respectively, and adding the first and fourth amplitudes and the second and third amplitudes respectively generating first and second added signals. Finally, the detector includes a comparator, connected to the first and second adders, and comparing the first and second added signals and detecting the abnormal condition in the plant compressor when the second added signal exceeds the first added signal by a predetermined value.

  7. Multichannel Decoded Local Binary Patterns for Content-Based Image Retrieval.

    PubMed

    Dubey, Shiv Ram; Singh, Satish Kumar; Singh, Rajat Kumar

    2016-09-01

    Local binary pattern (LBP) is widely adopted for efficient image feature description and simplicity. To describe the color images, it is required to combine the LBPs from each channel of the image. The traditional way of binary combination is to simply concatenate the LBPs from each channel, but it increases the dimensionality of the pattern. In order to cope with this problem, this paper proposes a novel method for image description with multichannel decoded LBPs. We introduce adder- and decoder-based two schemas for the combination of the LBPs from more than one channel. Image retrieval experiments are performed to observe the effectiveness of the proposed approaches and compared with the existing ways of multichannel techniques. The experiments are performed over 12 benchmark natural scene and color texture image databases, such as Corel-1k, MIT-VisTex, USPTex, Colored Brodatz, and so on. It is observed that the introduced multichannel adder- and decoder-based LBPs significantly improve the retrieval performance over each database and outperform the other multichannel-based approaches in terms of the average retrieval precision and average retrieval rate. PMID:27295674

  8. Complementary code and digital filtering for detection of weak VHF radar signals from the mesoscale. [SOUSY-VHF radar, Harz Mountains, Germany

    NASA Technical Reports Server (NTRS)

    Schmidt, G.; Ruster, R.; Czechowsky, P.

    1983-01-01

    The SOUSY-VHF-Radar operates at a frequency of 53.5 MHz in a valley in the Harz mountains, Germany, 90 km from Hanover. The radar controller, which is programmed by a 16-bit computer holds 1024 program steps in core and controls, via 8 channels, the whole radar system: in particular the master oscillator, the transmitter, the transmit-receive-switch, the receiver, the analog to digital converter, and the hardware adder. The high-sensitivity receiver has a dynamic range of 70 dB and a video bandwidth of 1 MHz. Phase coding schemes are applied, in particular for investigations at mesospheric heights, in order to carry out measurements with the maximum duty cycle and the maximum height resolution. The computer takes the data from the adder to store it in magnetic tape or disc. The radar controller is programmed by the computer using simple FORTRAN IV statements. After the program has been loaded and the computer has started the radar controller, it runs automatically, stopping at the program end. In case of errors or failures occurring during the radar operation, the radar controller is shut off caused either by a safety circuit or by a power failure circuit or by a parity check system.

  9. Detector for flow abnormalities in gaseous diffusion plant compressors

    DOEpatents

    Smith, S.F.; Castleberry, K.N.

    1998-06-16

    A detector detects a flow abnormality in a plant compressor which outputs a motor current signal. The detector includes a demodulator/lowpass filter demodulating and filtering the motor current signal producing a demodulated signal, and first, second, third and fourth bandpass filters connected to the demodulator/lowpass filter, and filtering the demodulated signal in accordance with first, second, third and fourth bandpass frequencies generating first, second, third and fourth filtered signals having first, second, third and fourth amplitudes. The detector also includes first, second, third and fourth amplitude detectors connected to the first, second, third and fourth bandpass filters respectively, and detecting the first, second, third and fourth amplitudes, and first and second adders connected to the first and fourth amplitude detectors and the second and third amplitude detectors respectively, and adding the first and fourth amplitudes and the second and third amplitudes respectively generating first and second added signals. Finally, the detector includes a comparator, connected to the first and second adders, and comparing the first and second added signals and detecting the abnormal condition in the plant compressor when the second added signal exceeds the first added signal by a predetermined value. 6 figs.

  10. The effect of CO2 regulations on the cost of corn ethanol production

    NASA Astrophysics Data System (ADS)

    Plevin, R. J.; Mueller, S.

    2008-04-01

    To explore the effect of CO2 price on the effective cost of ethanol production we have developed a model that integrates financial and emissions accounting for dry-mill corn ethanol plants. Three policy options are modeled: (1) a charge per unit of life cycle CO2 emissions, (2) a charge per unit of direct biorefinery emissions only, and (3) a low carbon fuel standard (LCFS). A CO2 charge on life cycle emissions increases production costs by between 0.005 and 0.008 l-1 per 10 Mg-1 CO2 price increment, across all modeled plant energy systems, with increases under direct emissions somewhat lower in all cases. In contrast, a LCFS increases the cost of production for selected plant energy systems only: a LCFS requiring reductions in average fuel global warming intensity (GWI) with a target of 10% below the 2005 baseline increases the production costs for coal-fired plants only. For all other plant types, the LCFS operates as a subsidy. The findings depend strongly on the magnitude of a land use change adder. Some land use change adders currently discussed in the literature will push the GWI of all modeled production systems above the LCFS target, flipping the CO2 price from a subsidy to a tax.

  11. Back-streaming ion beam measurements in a Self Magnetic Insulated (SMP) electron diode

    NASA Astrophysics Data System (ADS)

    Mazarakis, Michael; Johnston, Mark; Kiefer, Mark; Leckbee, Josh; Webb, Timothy; Bennett, Nichelle; Droemer, Darryl; Welch, Dale; Nielsen, Dan; Ziska, Derek; Wilkins, Frank; Advance radiography department Team

    2014-10-01

    A self-magnetic pinch diode (SMP) is presently the electron diode of choice for high energy flash x-ray radiography utilizing pulsed power drivers. The Sandia National Laboratories RITS accelerator is presently fit with an SMP diode that generates very small electron beam spots. RITS is a Self-Magnetically Insulated Transmission Line (MITL) voltage adder that adds the voltage pulse of six 1.3 MV inductively insulated cavities. The diode's anode is made of high Z metal in order to produce copious and energetic flash x-rays for radiographic imaging of high areal density objects. In any high voltage inductive voltage adder (IVA) utilizing MITLs to transmit the power to the diode load, the precise knowledge of the accelerating voltage applied on the anode-cathode (A-K) gap is problematic. This is even more difficult in an SMP diode where the A-K gap is very small (~1 cm) and the diode region very hostile. We are currently measuring the back-streaming ion currents emitted from the anode and propagating through a hollow cathode tip. We then are evaluating the A-K gap voltage by ion time of flight measurements supplemented with filtered Rogowski coils. Sandia is a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under Contract No. DE- AC04-94AL850.

  12. Epidemiology of snakebite in Eshowe, KwaZulu-Natal, South Africa.

    PubMed

    Blaylock, Roger

    2004-02-01

    Three hundred and thirty-three patients admitted to Eshowe Hospital with snakebite were analysed. Forty-one were non-envenomed, 282 exhibited painful progressive swelling (PPS), seven showed progressive weakness (PW), and there were three cases of minor envenomations that were unclassifiable. Offending dead venomous snakes included Naja mossambica (Mozambique spitting cobra), Bitis arietans (puff adder), Atractaspis bibronii (stiletto snake), Causus rhombeatus (common night adder) and Dendroaspis polylepis (black mamba). Most bites occurred on the leg in the wet summer months during the first three decades of the patients' lives. The majority of patients used a first-aid measure. The snake was most commonly sighted if the patient was bitten on an upper limb or above the ankle. Severe envenomation was associated with quicker arrival at hospital, and multiple bites occurred more frequently in sleeping patients. Non-envenomation following snakebites was more common in winter, in adult females, and if the patient was bitten proximally on a limb or on a hand. Patients with PPS developed bite site complications (42), compartment syndromes (4), femoral vessel entrapment (1), deep vein thrombosis (1), and respiratory complications (4). Severe swelling was associated with spring and early summer, proximal limb bites and children who were most at risk of necrosis. Fingers and hands were most prone to necrosis and permanent disability. Four patients with PW developed respiratory failure. Antivenom was administered to 12 patients, five of whom developed an acute adverse reaction. There was one death. PMID:15019475

  13. A mechanistic stochastic framework for regulating bacterial cell division.

    PubMed

    Ghusinga, Khem Raj; Vargas-Garcia, Cesar A; Singh, Abhyudai

    2016-01-01

    How exponentially growing cells maintain size homeostasis is an important fundamental problem. Recent single-cell studies in prokaryotes have uncovered the adder principle, where cells add a fixed size (volume) from birth to division, irrespective of their size at birth. To mechanistically explain the adder principle, we consider a timekeeper protein that begins to get stochastically expressed after cell birth at a rate proportional to the volume. Cell-division time is formulated as the first-passage time for protein copy numbers to hit a fixed threshold. Consistent with data, the model predicts that the noise in division timing increases with size at birth. Intriguingly, our results show that the distribution of the volume added between successive cell-division events is independent of the newborn cell size. This was dramatically seen in experimental studies, where histograms of the added volume corresponding to different newborn sizes collapsed on top of each other. The model provides further insights consistent with experimental observations: the distribution of the added volume when scaled by its mean becomes invariant of the growth rate. In summary, our simple yet elegant model explains key experimental findings and suggests a mechanism for regulating both the mean and fluctuations in cell-division timing for controlling size. PMID:27456660

  14. Slime mould logic gates based on frequency changes of electrical potential oscillation.

    PubMed

    Whiting, James G H; de Lacy Costello, Ben P J; Adamatzky, Andrew

    2014-10-01

    Physarum polycephalum is a large single amoeba cell, which in its plasmodial phase, forages and connects nearby food sources with protoplasmic tubes. The organism forages for food by growing these tubes towards detected foodstuff, this foraging behaviour is governed by simple rules of photoavoidance and chemotaxis. The electrical activity of the tubes oscillates, creating a peristaltic like action within the tubes, forcing cytoplasm along the lumen; the frequency of this oscillation controls the speed and direction of growth. External stimuli such as light and food cause changes in the oscillation frequency. We demonstrate that using these stimuli as logical inputs we can approximate logic gates using these tubes and derive combinational logic circuits by cascading the gates, with software analysis providing the output of each gate and determining the input of the following gate. Basic gates OR, AND and NOT were correct 90%, 77.8% and 91.7% of the time respectively. Derived logic circuits XOR, half adder and full adder were 70.8%, 65% and 58.8% accurate respectively. Accuracy of the combinational logic decreases as the number of gates is increased, however they are at least as accurate as previous logic approximations using spatial growth of P. polycephalum and up to 30 times as fast at computing the logical output. The results shown here demonstrate a significant advancement in organism-based computing, providing a solid basis for hybrid computers of the future. PMID:25102081

  15. Structural and Pharmacological Comparison of Daboiatoxin from Badoia russelli siamensis with Viperotoxing F and Vipoxin from Other Vipers

    SciTech Connect

    Gopolan,G.; Thwin, M.; Gopalakrishnakone, P.; Swaminathan, K.

    2007-01-01

    Russell's viper (Vipera russelli, also known as Daboia russelli) is one of the major causes of fatal snakebites. To date, five Daboia russelli subspecies have been recognized. Daboiatoxin (DbTx) is the main lethal phospholipase A{sub 2} (PLA{sub 2}) toxin in the venom of D. russelli siamensis (Myanmar viper) and has strong neurotoxic, myotoxic and cytotoxic activities. DbTx and its homologous neurotoxins viperotoxin F from D. russelli formosensis (Taiwan viper) and vipoxin from the Bulgarian sand viper V. ammodytes meridionalis consist of complexes between a nontoxic acidic PLA2 protein and an enzymatically active basic PLA2. DbTx and viperotoxin F are presynaptic toxins, while vipoxin is postsynaptic. The two chains of DbTx have been separated and their PLA2 enzymatic activity has been measured using the secretory PLA2 assay kit. The enzymatic activity of DbTx chain B is reduced by 30% of its original activity by chain A in a unimolar ratio, thus indicating that DbTx chain A acts as an inhibitor. The lethal activity of the two chains has also been studied in male albino mice and chain A is less lethal than chain B. The crystal structure of DbTx has also been determined and its structural details are compared with those of the two homologues. Furthermore, an attempt is made to correlate the sequence and structural determinants of these toxins with their enzymatic activities and their pharmacological effects.

  16. Alleviation of viper venom induced platelet apoptosis by crocin (Crocus sativus): implications for thrombocytopenia in viper bites.

    PubMed

    Santhosh, M Sebastin; Thushara, R M; Hemshekhar, M; Sunitha, K; Devaraja, S; Kemparaju, K; Girish, K S

    2013-11-01

    Viper envenomations are characterized by prominent local and systemic manifestations including hematological alterations. Snake venom metalloproteinases (SVMPs) and phospholipase A2 (PLA2) plays crucial role in the pathophysiology of hemorrhage by targeting/altering the platelets function which may result in thrombocytopenia. Platelets undergo the classic events of mitochondria-mediated apoptotic pathway due to augmented endogenous reactive oxygen species (ROS) levels. The observed anticoagulant effects during viper envenomations could be due to exacerbated platelet apoptosis and thrombocytopenia. Moreover, antivenin treatments are ineffective against the venom-induced oxidative stress; therefore, it necessitates an auxiliary therapy involving antioxidants which can effectively scavenge the endothelium-generated/endogenous ROS and protect the platelets. The present study explored the effects of viper venom on platelet apoptosis and its amelioration by a phytochemical crocin. The study evaluated the Vipera russelli venom-induced apoptotic events including endogenous ROS generation, intracellular Ca(2+) mobilization, mitochondrial membrane depolarization, cyt-c translocation, caspase activation and phosphatidylserine externalization which were effectively mitigated when the venom was pre-treated with crocin. The study highlights one of the less studied features of venom-induced secondary complications i.e. platelet apoptosis and sheds light on the underlying basis for venom-induced thrombocytopenia, systemic hemorrhage and in vivo anticoagulant effect. PMID:23412973

  17. Antibacterial potential of a basic phospholipase A2 (VRV-PL-V) of Daboia russellii pulchella (Russell's Viper) venom.

    PubMed

    Sudarshan, S; Dhananjaya, B L

    2014-11-01

    Microbial/bacterial resistance against antibiotics is considered as a potentially serious threat to public health. Further, as these antibiotics elicit side effects, there is interest in developing new molecules with novel modes of action from diverse organisms. Along these lines, in this study the antibacterial potential of the basic protein VRV-PL-V (Vipera russellii venom phospholipase A2 fraction V) of Daboia russellii pulchella venom was evaluated. VRV-PL-V demonstrated a potent antibacterial activity against all the human pathogenic strains tested. It inhibited more effectively Gram-positive bacteria like Staphylococcus aureus and Bacillus subtilis when compared to Gram-negative bacteria like Escherichia coli, Vibrio cholerae, Klebsiella pneumoniae, and Salmonella paratyphi. It inhibited bacterial growth with MIC values ranging from 13 to 24 µg/ml. The antibacterial potential of VRV-PL-V was comparable to the standards used like gentamycin, chloramphenicol, and streptomycin. There was a strong correlation between PLA2 activities and hemolytic and antibacterial activity. It was found that even in the presence of p-bromophenacyl bromide (an inhibitor of PLA2 enzymatic activity), there was marked antibacterial activity, suggesting dissociation or partial overlapping of the bactericidal/antimicrobial domains. Therefore, this study shows that although there is a strong correlation between enzymatic and antimicrobial activities of VRV-PL-V, it may also possess other properties that mimic bactericidal/membrane permeability-increasing protein. PMID:25540009

  18. Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms.

    PubMed

    Ghazaryan, Narine A; Ghulikyan, Lusine; Kishmiryan, Arsen; Andreeva, Tatyana V; Utkin, Yuri N; Tsetlin, Victor I; Lomonte, Bruno; Ayvazyan, Naira M

    2015-02-01

    We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae (Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs) composed of natural brain phospholipids mixture, visualized through fluorescence microscopy. The membrane fluorescent probes 8-anilino-1-naphthalenesulfonicacid (ANS), LAUDRAN and PRODAN were used to assess the state of the membrane and specifically mark the lipid packing and membrane fluidity. Our results have shown that the three PLA2s which contain either of aspartic acid, serine, or lysine residues at position 49 in the catalytic center, have different effects on the vesicles. The PLA2 with aspartic acid at this position causes the oval deformation of the vesicles, while serine and lysine-containing enzymes lead to an appreciable increase of fluorescence intensity in the vesicles membrane, wherein the shape and dimensions of GUVs have not changed, but in this case GUV aggregation occurs. LAURDAN and PRODAN detect the extent of water penetration into the bilayer surface. We calculated generalized polarization function (GP), showing that for all cases (D49 PLA2, S49 PLA2 and K49 PLA2) both LAUDRAN and PRODAN GP values decrease. A higher LAURDAN GP is indicative of low water penetration in the lipid bilayer in case of K49 PLA2 compared with D49 PLA2, whereas the PRODAN mainly gives information when lipid is in liquid crystalline phase. PMID:25450350

  19. Long term variations in small mammal composition of a snake diet do not mirror climate change trends

    NASA Astrophysics Data System (ADS)

    Rugiero, Lorenzo; Milana, Giuliano; Capula, Massimo; Amori, Giovanni; Luiselli, Luca

    2012-08-01

    The study of the dietary changes which have intervened over the years in generalist and opportunist predators may provide useful information on the temporal modifications of their prey communities, especially under a climate change scenario. In this study, we analysed the quantitative changes in the small mammal portion of the diet of a generalist and opportunist predator, the asp viper (Vipera aspis) at a forest zone in central Italy, for the period 1987-2010. In addition, small mammals were trapped in five of these years. Apodemus spp., Mus musculus, and Myodes glareolus were the main prey for vipers. Among the various taxa eaten by vipers, only two showed significantly consistent trends over the years, with M. glareolus increasing and Sorex spp. declining in the viper diet. There were no significant relationships between the number of years passed after the first year of sampling and the diversity and dominance indexes of prey composition. We also found a significantly positive relationship between small mammal abundance in the field and their relative frequency of occurrence in the viper's diet, thus demonstrating that vipers really sampled the small mammal species in relation to their local availability. Despite being temperate-zone forest-associated species, hence likely adversed by global warming, Sorex spp. and M. glareolus showed opposite trends over the years, thus suggesting that such trends may reflect more local scale perturbations (local forest overgrowth and diminution of logging).

  20. Correlations between benthic habitats and demersal fish assemblages — A case study on the Dogger Bank (North Sea)

    NASA Astrophysics Data System (ADS)

    Sell, Anne F.; Kröncke, Ingrid

    2013-07-01

    The interdependence between groundfish assemblages and habitat properties was investigated on the Dogger Bank in the North Sea. Abiotic habitat parameters considered included topography, hydrographic conditions, sediment composition, and the biotic habitat variable the prevailing benthic invertebrates. Distinct epi- and infauna communities occurred at different locations on the Dogger Bank. Fish assemblages were clearly linked to both the biotic and abiotic habitat characteristics. Overall, fish and benthic communities revealed similar spatial distribution, represented in the respective clusters of characteristic and abundant species. Distribution patterns corresponded with the prevailing abiotic conditions such as depth and sediment composition, which appear to relate to autecological preferences of individual species. The apparently most generalist species, grey gurnard (Eutrigla gurnardus) and dab (Limanda limanda) occurred at all stations and dominated in terms of biomass in most cases. The absolute numbers of grey gurnards were related to the abundance of suitable prey, invertebrate and fish species, which stomach analyses revealed as part of the diet in an independent study during the same research cruise. Haddock (Melanogrammus aeglefinus) and whiting (Merlangius merlangus) were only abundant at deep stations along the flanks of the bank. The occurrence of lemon sole (Microstomus kitt), American plaice (Hippoglossoides platessoides) and cod (Gadus morhua) was also positively correlated with depth, whereas especially lesser weever (Echiichthys vipera), sandeel species and solenette (Buglossidium luteum) occurred predominantly at the shallower sites. At the same time, individual fish species such as solenette and lesser weever were associated with high densities of selected epi- or infauna species.

  1. Are glucocorticoids good indicators of pregnancy constraints in a capital breeder?

    PubMed

    Lorioux, Sophie; Angelier, Frédéric; Lourdais, Olivier

    2016-06-01

    Pregnancy imposes a substantial energetic demand on the mother (i.e. metabolic costs of pregnancy) and is often associated with modified maternal behavior and increased physical burdens that make females more vulnerable to predation. The Hypothalamic-Pituitary-Adrenal axis plays a fundamental role in reproduction through hormonal control of energy regulation and parental care. Therefore, evaluating the changes in baseline and stress-induced glucocorticoid levels in response to pregnancy may provide a robust tool to assess not only the constraints of gestation but also the way females may adjust to these constraints. In this study, we measured baseline and stress-induced corticosterone (CORT) concentrations in pregnant and non-pregnant aspic vipers (Vipera aspis), which are capital breeders. We also measured muscle condition (tail width) and locomotion performance (traction force) because these are robust proxies of protein mobilization associated with fasting. Baseline CORT concentration increased significantly over time in pregnant females, while they were lower and stable in non-reproductive females. Pregnant females had lower muscle condition at the onset of the study and tail width was negatively correlated with CORT concentration in this group. Contrary to our prediction, the stress response was not attenuated in pregnant females, but was proportional to baseline CORT concentration. Our results suggest that baseline CORT variations are closely related to energy constraints and structural protein mobilization in this capital breeder. PMID:27090427

  2. Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression

    PubMed Central

    Son, Dong Ju; Song, Ho Sub; Kim, Jung Hyun; Ko, Seong Cheol; Song, Min Jong; Lee, Won Hyoung; Yoon, Joo Hee; Ham, Young Wan; Han, Sang Bae; Hong, Jin Tae

    2015-01-01

    Snake venom toxin (SVT) from Vipera lebetina turanica contains a mixture of different enzymes and proteins. Peroxiredoxin 6 (PRDX6) is known to be a stimulator of lung cancer cell growth. PRDX6 is a member of peroxidases, and has calcium-independent phospholipase A2 (iPLA2) activities. PRDX6 has an AP-1 binding site in its promoter region of the gene. Since AP-1 is implicated in tumor growth and PRDX6 expression, in the present study, we investigated whether SVT inhibits PRDX6, thereby preventing human lung cancer cell growth (A549 and NCI-H460) through inactivation of AP-1. A docking model study and pull down assay showed that SVT completely fits on the basic leucine zipper (bZIP) region of c-Fos of AP-1. SVT (0–10 μg/ml) inhibited lung cancer cell growth in a concentration dependent manner through induction of apoptotic cell death accompanied by induction of cleaved caspase-3, -8, -9, Bax, p21 and p53, but decreased cIAP and Bcl2 expression via inactivation of AP-1. In an xenograft in vivo model, SVT (0.5 mg/kg and 1 mg/kg) also inhibited tumor growth accompanied with the reduction of PRDX6 expression, but increased expression of proapoptotic proteins. These data indicate that SVT inhibits tumor growth via inhibition of PRDX6 activity through interaction with its transcription factor AP-1. PMID:26061816

  3. Energy and delay trade-offs in arithmetic circuits: Methodologies and optimizations

    NASA Astrophysics Data System (ADS)

    Baran, Dursun

    Technology scaling cannot provide sufficient amount of energy reduction to keep control of the energy consumption of the current VLSI systems. In order to solve the problem of the high power dissipation of current processors, a complete optimization framework is developed. The system architecture, circuit topology, gate sizes and the technology related parameters are optimized jointly. For this purpose, circuit design methodologies are developed for demanded applications. The developed circuit design techniques target two objectives namely critical path complexity reduction of the circuit and the equalization of the signal path complexities. The generated circuit topologies are candidates for the energy efficient design. The final determination of the best circuit topology is made after optimizing the gate sizes and the voltage supply of the design. For this purpose, a quick circuit sizing algorithm (Constant Stage Effort Ratio) is developed. The algorithm redistributes the effort delay through the circuit to reduce the energy consumption at the same performance. The run-time of the developed algorithm linearly depends on the number of the logic gates in the circuit. By using the developed algorithm, a considerable amount of the run-time improvement is obtained. The developed optimization framework is applied to the parallel prefix adders and parallel multipliers. Up to 4.5X energy saving is obtained by the use of the design methodologies in 64-bit parallel adders over existing designs. Energy-efficient parallel adder structures are developed for static, domino and compound domino logic families. The suitability of the developed design techniques are explored in future technology nodes as well. Similar analysis is performed to the parallel multipliers. 16x16-bit serial, single-cycle parallel and two-cycle parallel multiplier structures are optimized using the developed optimization flow. Up to 20% energy reduction is obtained in static single-cycle 16x16-bit

  4. Ka-Band Wide-Bandgap Solid-State Power Amplifier: Prototype Combiner Spurious Mode Suppression and Power Constraints

    NASA Technical Reports Server (NTRS)

    Khan, P.; Epp, L.

    2006-01-01

    Results of prototype hardware activities related to a 120-W, 32-GHz (Ka-band) solid-state power amplifier (SSPA) architecture study are presented. Spurious mode suppression and the power-handling capability of a prototype 24-way radial combiner and a prototype 2-way septum binary combiner were investigated. Experimental data indicate that a commercial absorptive filter, designed to pass the circular TE01 mode, effectively suppressed the higher-order modes generated by a narrowband, flower-petal-type mode transducer. However, the same filter was not effective in suppressing higher-order modes generated by the broadband Marie mode transducer that is used in the prototype waveguide radial combiner. Should greater filtering be required by a particular SSPA application, a broadband mode filter that can suppress specifically those higher-order modes that are generated by the Marie transducer will need to be developed. A back-to-back configuration of the prototype radial combiner was tested with drive power up to approximately 50 W. No anomalous behavior was observed. Power measurements of the septum combiner indicate that up to 10-W radio frequency (RF) can be dissipated in the integrated resistive element before a permanent performance shift is observed. Thus, a given adder (a single-stage, 2-way combiner) can safely combine two 20-W sources, and the adder will not be damaged in the event of a source failure. This result is used to calculate the maximum source power that can be safely combined as a function of the number of sources combined and the number of source failures allowed in a multi-stage combiner. The analysis shows that SSPA power >140 W can be generated by power combining 16 sources producing 10 W each. In this configuration, up to three sources could fail with the guarantee that the combiner would not be damaged. Finally, a modified prototype septum combiner design was verified. The improved design reduced the assembly time from over 2 hours to about 15

  5. Mode junction photonics with a symmetry-breaking arrangement of mode-orthogonal heterostructures.

    PubMed

    Yu, Sunkyu; Piao, Xianji; Koo, Sukmo; Shin, Jung H; Lee, Seung Hoon; Min, Bumki; Park, Namkyoo

    2011-12-01

    Junction structures provide the foundation of digital electronics and spintronics today. An equivalent, a photonic junction to achieve systematic and drastic control of photon flow is currently missing, but is mandatory for serious all-optical signal processing. Here we propose a photonic junction built upon mode-orthogonal hetero-structures, as a fundamental structural unit for photonic integrated circuits. Controlling the optical potential of mode-orthogonal junctions, the flow of photons can be dynamically manipulated, to complete the correspondence to the electronic junction structures. Of the possible applications, we provide examples of a photonic junction diode and a multi-junction half-adder, with exceptional performance metrics. Highly directional (41dB), nearly unity throughput, ultra-low threshold-power, high quality signal regeneration at 200Gb/s, and all-optic logic operations are successfully derived with the self-induced, bi-level dynamic mode-conversion process across the junction. PMID:22273943

  6. 1D linear-phase band-pass multiplierless FIR Hilbert transformers and filters

    NASA Astrophysics Data System (ADS)

    Pavlović, Vlastimir D.; Dončov, Nebojša S.; Ćirić, Dejan G.

    2016-06-01

    An original analytical method, based on modified Christoffel-Darboux formula, is used in the paper in order to synthesise a linear-phase band-pass finite impulse response (FIR) filter function that can have an effect of Hilbert transformer. New structure of the band-pass FIR filter in recursive realisation, together with the corresponding difference equation, is presented providing the efficient filter solution without multipliers. Several examples of filter types for different parity of two real free integer parameters, including a particular solution of Hilbert transformer, are considered in terms of required number of adders and values of cut-off frequencies of the pass and stop bands. A comparison of the proposed band-pass filter characteristics with those of a classical filter solution is provided in the paper.

  7. Techniques for computing the discrete Fourier transform using the quadratic residue Fermat number systems

    NASA Technical Reports Server (NTRS)

    Truong, T. K.; Chang, J. J.; Hsu, I. S.; Pei, D. Y.; Reed, I. S.

    1986-01-01

    The complex integer multiplier and adder over the direct sum of two copies of finite field developed by Cozzens and Finkelstein (1985) is specialized to the direct sum of the rings of integers modulo Fermat numbers. Such multiplication over the rings of integers modulo Fermat numbers can be performed by means of two integer multiplications, whereas the complex integer multiplication requires three integer multiplications. Such multiplications and additions can be used in the implementation of a discrete Fourier transform (DFT) of a sequence of complex numbers. The advantage of the present approach is that the number of multiplications needed to compute a systolic array of the DFT can be reduced substantially. The architectural designs using this approach are regular, simple, expandable and, therefore, naturally suitable for VLSI implementation.

  8. An Approach for Self-Timed Synchronous CMOS Circuit Design

    NASA Technical Reports Server (NTRS)

    Walker, Alvernon; Lala, Parag K.

    2001-01-01

    In this letter we present a timing and control strategy that can be used to realize synchronous systems with a level of performance that approaches that of asynchronous circuits or systems. This approach is based upon a single-phase synchronous circuit/system architecture with a variable period clock. The handshaking signals required for asynchronous self-timed circuits are not needed. Dynamic power supply current monitoring is used to generate the timing information, that is comparable to the completion signal found in self-timed circuits; this timing information is used to modi@ the circuit clock period. This letter is concluded with an example of the proposed approach applied to a static CMOS ripple-carry adder.

  9. Note: All-digital pulse-shrinking time-to-digital converter with improved dynamic range.

    PubMed

    Chen, Chun-Chi; Hwang, Chorng-Sii; Lin, Yi; Chen, Guan-Hong

    2016-04-01

    This paper proposes an all-digital pulse-shrinking time-to-digital converter (TDC) using the offset error cancellation circuitry to widen its dynamic range and to improve its accuracy. Although the TDC based on a pulse-shrinking mechanism can achieve a sub-gate resolution without circuit complexity, it possesses an undesired offset error that results in a nonzero lower bound appeared in its dynamic range and then affects its accuracy. The proposed cancellation circuitry for eliminating the offset error consists of a time adder with a delay line and a time subtractor with an identical delay line. The experimental TDC is implemented on Xilinx field programmable gate arrays and it also functions successfully in improving its dynamic range. PMID:27131720

  10. A HIGH CURRENT, HIGH VOLTAGE SOLID-STATE PULSE GENERATOR FOR THE NIF PLASMA ELECTRODE POCKELS CELL

    SciTech Connect

    Arnold, P A; Barbosa, F; Cook, E G; Hickman, B C; Akana, G L; Brooksby, C A

    2007-07-27

    A high current, high voltage, all solid-state pulse modulator has been developed for use in the Plasma Electrode Pockels Cell (PEPC) subsystem in the National Ignition Facility. The MOSFET-switched pulse generator, designed to be a more capable plug-in replacement for the thyratron-switched units currently deployed in NIF, offers unprecedented capabilities including burst-mode operation, pulse width agility and a steady-state pulse repetition frequency exceeding 1 Hz. Capable of delivering requisite fast risetime, 17 kV flattop pulses into a 6 {Omega} load, the pulser employs a modular architecture characteristic of the inductive adder technology, pioneered at LLNL for use in acceleration applications, which keeps primary voltages low (and well within the capabilities of existing FET technology), reduces fabrication costs and is amenable to rapid assembly and quick field repairs.

  11. VLSI processors for signal detection in SETI

    NASA Technical Reports Server (NTRS)

    Duluk, J. F.; Linscott, I. R.; Peterson, A. M.; Burr, J.; Ekroot, B.; Twicken, J.

    1989-01-01

    The objective of the Search for Extraterrestrial Intelligence (SETI) is to locate an artificially created signal coming from a distant star. This is done in two steps: (1) spectral analysis of an incoming radio frequency band, and (2) pattern detection for narrow-band signals. Both steps are computationally expensive and require the development of specially designed computer architectures. To reduce the size and cost of the SETI signal detection machine, two custom VLSI chips are under development. The first chip, the SETI DSP Engine, is used in the spectrum analyzer and is specially designed to compute Discrete Fourier Transforms (DFTs). It is a high-speed arithmetic processor that has two adders, one multiplier-accumulator, and three four-port memories. The second chip is a new type of Content-Addressable Memory. It is the heart of an associative processor that is used for pattern detection. Both chips incorporate many innovative circuits and architectural features.

  12. Integrated logic circuits using single-atom transistors

    PubMed Central

    Mol, J. A.; Verduijn, J.; Levine, R. D.; Remacle, F.

    2011-01-01

    Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. Single-atom transistors, SATs, cascaded in a circuit are proposed as a promising route that is compatible with existing technology. We demonstrate the use of quantum degrees of freedom to perform logic operations in a complementary-metal–oxide–semiconductor device. Each SAT performs multilevel logic by electrically addressing the electronic states of a dopant atom. A single electron transistor decodes the physical multivalued output into the conventional binary output. A robust scalable circuit of two concatenated full adders is reported, where by utilizing charge and quantum degrees of freedom, the functionality of the transistor is pushed far beyond that of a simple switch. PMID:21808050

  13. Numerically controlled oscillator for the Fermilab booster

    SciTech Connect

    Crisp, J.L.; Ducar, R.J.

    1989-04-01

    In order to improve the stability of the Fermilab Booster low level rf system, a numerically controlled oscillator system is being constructed. Although the system has not been implemented to date, the design is outlined in this paper. The heart of the new system consists of a numerically synthesized frequency generator manufactured by the Sciteq Company. The 3 Ghz/sec rate and 30 to 53 MHz range of the Booster frequency program required the design of a CAMAC based, fast-cycling (1 MHz), 65K X 32 bit, digital function generator. A 1 MHz digital adder and 12 bit analog to digital converter will be used to correct small program errors by phase locking the oscillator to the beam. 6 refs., 1 fig.

  14. Note: A pulsed laser ion source for linear induction accelerators

    SciTech Connect

    Zhang, H.; Zhang, K.; Shen, Y.; Jiang, X.; Dong, P.; Liu, Y.; Wang, Y.; Chen, D.; Pan, H.; Wang, W.; Jiang, W.; Long, J.; Xia, L.; Shi, J.; Zhang, L.; Deng, J.

    2015-01-15

    We have developed a high-current laser ion source for induction accelerators. A copper target was irradiated by a frequency-quadrupled Nd:YAG laser (266 nm) with relatively low intensities of 10{sup 8} W/cm{sup 2}. The laser-produced plasma supplied a large number of Cu{sup +} ions (∼10{sup 12} ions/pulse) during several microseconds. Emission spectra of the plasma were observed and the calculated electron temperature was about 1 eV. An induction voltage adder extracted high-current ion beams over 0.5 A/cm{sup 2} from a plasma-prefilled gap. The normalized beam emittance measured by a pepper-pot method was smaller than 1 π mm mrad.

  15. Note: A pulsed laser ion source for linear induction accelerators

    NASA Astrophysics Data System (ADS)

    Zhang, H.; Zhang, K.; Shen, Y.; Jiang, X.; Dong, P.; Liu, Y.; Wang, Y.; Chen, D.; Pan, H.; Wang, W.; Jiang, W.; Long, J.; Xia, L.; Shi, J.; Zhang, L.; Deng, J.

    2015-01-01

    We have developed a high-current laser ion source for induction accelerators. A copper target was irradiated by a frequency-quadrupled Nd:YAG laser (266 nm) with relatively low intensities of 108 W/cm2. The laser-produced plasma supplied a large number of Cu+ ions (˜1012 ions/pulse) during several microseconds. Emission spectra of the plasma were observed and the calculated electron temperature was about 1 eV. An induction voltage adder extracted high-current ion beams over 0.5 A/cm2 from a plasma-prefilled gap. The normalized beam emittance measured by a pepper-pot method was smaller than 1 π mm mrad.

  16. Recent Advances in Photonic Devices for Optical Computing and the Role of Nonlinear Optics-Part II

    NASA Technical Reports Server (NTRS)

    Abdeldayem, Hossin; Frazier, Donald O.; Witherow, William K.; Banks, Curtis E.; Paley, Mark S.

    2007-01-01

    The twentieth century has been the era of semiconductor materials and electronic technology while this millennium is expected to be the age of photonic materials and all-optical technology. Optical technology has led to countless optical devices that have become indispensable in our daily lives in storage area networks, parallel processing, optical switches, all-optical data networks, holographic storage devices, and biometric devices at airports. This chapters intends to bring some awareness to the state-of-the-art of optical technologies, which have potential for optical computing and demonstrate the role of nonlinear optics in many of these components. Our intent, in this Chapter, is to present an overview of the current status of optical computing, and a brief evaluation of the recent advances and performance of the following key components necessary to build an optical computing system: all-optical logic gates, adders, optical processors, optical storage, holographic storage, optical interconnects, spatial light modulators and optical materials.

  17. Systolic array for fast computation of moment invariants

    NASA Astrophysics Data System (ADS)

    Liu, Jianguo; Chan, Francis H. Y.; Li, H. F.; Lam, F. K.

    1998-09-01

    Moment invariants, by virtue of invariance properties under translation, scaling and rotation, have played an important role in pattern recognition and computer vision. In the present paper, extending the systolic array for computing moments, a global systolic structure for fast computation of moment invariants has been proposed. This structure fully exploits parallelism of the network architecture and reduces computational time complexity from O(n2) in the case of direct computation to O(n) (n denotes image size). The systolic structure nearly consists of adders with area complexity O(n) and are highly regular and structurally very simple, resulting in simple hardware implementation. The method is suitable for both binary images and gray level images and is also suitable for image sequence moments.

  18. Continuous Fourier transform method and apparatus. [for the analysis of simultaneous analog signal components

    NASA Technical Reports Server (NTRS)

    Munoz, R. M. (Inventor)

    1974-01-01

    An input analog signal to be frequency analyzed is separated into N number of simultaneous analog signal components each identical to the original but delayed relative to the original by a successively larger time delay. The separated and delayed analog components are combined together in a suitable number of adders and attenuators in accordance with at least one component product of the continuous Fourier transform and analog signal matrices to separate the analog input signal into at least one of its continuous analog frequency components of bandwidth 1/N times the bandwidth of the original input signal. The original analog input signal can be reconstituted by combining the separate analog frequency components in accordance with the component products of the continuous Fourier transform and analog frequency component matrices. The continuous Fourier transformation is useful for spectrum analysis, filtering, transfer function synthesis, and communications.

  19. Performances of Induction System for Nanosecond Mode Operation

    SciTech Connect

    Krasnykh, Anatoly; /SLAC

    2006-05-16

    An induction system comprises an array of single turn pulse transformers. Ferromagnetic cores of transformers are toroids that are stacked along the longitudinal core axis. Another name for this array is a fraction transformer or an adder. The primary and secondary windings of such a design have one turn. The step up mode is based on the number of primary pulse sources. The secondary windings are connected in series. Performances of such a system for the nanosecond range mode operation are different in comparison to the performances of traditional multi-turn pulse transformers, which are working on a 100+ nanosecond mode operation. In this paper, the author discusses which aspects are necessary to take into account for the high power nanosecond fractional transformer designs. The engineering method of the nanosecond induction system design is presented.

  20. Large capacity, high-speed multiparameter multichannel analysis system

    SciTech Connect

    Hendricks, R.W.; Seeger, P.A.; Scheer, J.W.; Suehiro, S.

    1980-01-01

    A data acquisition system for recording multiparameter digital data into a large memory array at over 2.5 MHz is described. The system consists of a MOSTEK MK8600 2048K x 24-bit memory system, I/O ports to various external devices including the CAMAC dataway, a memory incrementer/adder and a daisy-chain of experiment-specific modules which calculate the memory address which is to be incremented. The design of the daisy-chain permits multiple modules and provides for easy modification as experimental needs change. The system has been designed for use in multiparameter, multichannel analysis of high-speed data gathered by position-sensitive detectors at conventional and synchrotron x-ray sources as well as for fixed energy and time-of-flight diffraction at continuous and pulsed neutron sources.

  1. A bit-serial VLSI array processing chip for image processing

    NASA Technical Reports Server (NTRS)

    Heaton, Robert; Blevins, Donald; Davis, Edward

    1990-01-01

    An array processing chip integrating 128 bit-serial processing elements (PEs) on a single die is discussed. Each PE has a 16-function logic unit, a single-bit adder, a 32-b variable-length shift register, and 1 kb of local RAM. Logic in each PE provides the capability to mask PEs individually. A modified grid interconnection scheme allows each PE to communicate with each of its eight nearest neighbors. A 32-b bus is used to transfer data to and from the array in a single cycle. Instruction execution is pipelined, enabling all instructions to be executed in a single cycle. The 1-micron CMOS design contains over 1.1 x 10 to the 6th transistors on an 11.0 x 11.7-mm die.

  2. Note: All-digital pulse-shrinking time-to-digital converter with improved dynamic range

    NASA Astrophysics Data System (ADS)

    Chen, Chun-Chi; Hwang, Chorng-Sii; Lin, Yi; Chen, Guan-Hong

    2016-04-01

    This paper proposes an all-digital pulse-shrinking time-to-digital converter (TDC) using the offset error cancellation circuitry to widen its dynamic range and to improve its accuracy. Although the TDC based on a pulse-shrinking mechanism can achieve a sub-gate resolution without circuit complexity, it possesses an undesired offset error that results in a nonzero lower bound appeared in its dynamic range and then affects its accuracy. The proposed cancellation circuitry for eliminating the offset error consists of a time adder with a delay line and a time subtractor with an identical delay line. The experimental TDC is implemented on Xilinx field programmable gate arrays and it also functions successfully in improving its dynamic range.

  3. Matrix triangularization by fixed-point redundant CORDIC with constant scale factor

    NASA Astrophysics Data System (ADS)

    Lee, Jeong-A.; Lang, Tomas

    1990-11-01

    We develop a redundani CORDIC scheme where the scale factor is forced to be constant while computing angles for 2 x 1 plane rotations. Based on the scheme we present a fixed-point implementation of matrix triangularization by Luk''s parallel algorithm with the following additional features: (1) the final scaling operation is done by shifting (2) the number of iterations in CORDIC rotation unit is reduced by about 25 by expressing the direction of the rotation in radix-2 and radix-4 and (3) the conventional number representation of rotated output is obtained on-thefly not from a carry-propagate adder. The number of hardware modules and the speed are evaluated and compared with the previous CORDIC schemes.

  4. Algorithm-Based Error Detection Of A Cholesky Factor Updating Systolic Array Using Cordic Processors

    NASA Astrophysics Data System (ADS)

    Chou, S. I.; Rader, Charles M.

    1989-12-01

    Lincoln Laboratory has developed an architecture for a folded linear systolic array using fixed-point CORDIC processors, applicable to adaptive nulling for a radar sidelobe canceler. The algorithm implemented uses triangularization by Givens rotations to solve a least-squares problem in the voltage domain. In this paper, the implementation of an inexpensive algorithm-based error-detection scheme is proposed for this systolic array. Column average checksum encoding is intended to detect most errors caused by the failure of any single arithmetic unit. It retains or almost retains the 100% processor utilization of Lincoln Laboratory's novel design. For the case of 64 degrees of freedom, the increase in time complexity is only 3%. The increase in hardware is mainly two adders and two comparators per CORDIC processor. We believe that the small increase in cost will be amply offset by the improvement in system performance brought about by this error detection.

  5. Exploring hurdles to transfer : student experiences of applying knowledge across disciplines

    NASA Astrophysics Data System (ADS)

    Lappalainen, Jouni; Rosqvist, Juho

    2015-04-01

    This paper explores the ways students perceive the transfer of learned knowledge to new situations - often a surprisingly difficult prospect. The novel aspect compared to the traditional transfer studies is that the learning phase is not a part of the experiment itself. The intention was only to activate acquired knowledge relevant to the transfer target using a short primer immediately prior to the situation where the knowledge was to be applied. Eight volunteer students from either mathematics or computer science curricula were given a task of designing an adder circuit using logic gates: a new context in which to apply knowledge of binary arithmetic and Boolean algebra. The results of a phenomenographic classification of the views presented by the students in their post-experiment interviews are reported. The degree to which the students were conscious of the acquired knowledge they employed and how they applied it in a new context emerged as the differentiating factors.

  6. Off-line, built-in test techniques for VLSI circuits

    NASA Technical Reports Server (NTRS)

    Buehler, M. G.; Sievers, M. W.

    1982-01-01

    It is shown that the use of redundant on-chip circuitry improves the testability of an entire VLSI circuit. In the study described here, five techniques applied to a two-bit ripple carry adder are compared. The techniques considered are self-oscillation, self-comparison, partition, scan path, and built-in logic block observer. It is noted that both classical stuck-at faults and nonclassical faults, such as bridging faults (shorts), stuck-on x faults where x may be 0, 1, or vary between the two, and parasitic flip-flop faults occur in IC structures. To simplify the analysis of the testing techniques, however, a stuck-at fault model is assumed.

  7. All-optical arithmetic unit with the help of terahertz-optical-asymmetric-demultiplexer-based tree architecture

    NASA Astrophysics Data System (ADS)

    Gayen, Dilip Kumar; Nath Roy, Jitendra

    2008-03-01

    An all-optical arithmetic unit with the help of terahertz-optical-asymmetric-demultiplexer (TOAD)-based tree architecture is proposed. We describe the all-optical arithmetic unit by using a set of all-optical multiplexer, all-optical full-adder, and optical switch. The all-optical arithmetic unit can be used to perform a fast central processor unit using optical hardware components. We have tried to exploit the advantages of both optical tree architecture and TOAD-based switch to design an integrated all-optical circuit that can perform binary addition, addition with carry, subtract with borrow, subtract (2's complement), double, increment, decrement, and transfer operations.

  8. The COBRA accelerator pulsed-power driver for Cornell/Sandia ICF research

    SciTech Connect

    Smith, D.L.; Ingwersen, P.; Bennett, L.F.; Boyes, J.D.; Anderson, D.E.; Greenly, J.B.; Sudan, R.N.; Hammer, D.A.

    1995-07-01

    This paper introduces and describes the new Cornell Beam Research Accelerator, COBRA, the result of a three and one-half year collaboration. The flexible 4 to 5-MV, 100 to 250-kA, 46-ns pulse width accelerator is based on a four-cavity Inductive Voltage Adder (IVA) design. In addition to being a mix of new and existing components, COBRA is unique in the sense that each cavity is driven by a single pulse forming line, and the IVA output polarity may be reversed by rotating the cavities 1800 about their vertical axis. Our tests with negative high voltage on the inner MITL stalk indicate that the vacuum power flow has established reasonable azimuthal symmetry within about 2 ns (or 0.6 m) after the cavity output cap. Preliminary results with the accelerator, single cavity, and MITL are presented alone, with the design details and circuit model predictions.

  9. A Motor Speed Servo System Based on the Dual Loop PLL

    NASA Astrophysics Data System (ADS)

    Machida, Hidekazu; Kambara, Michinobu; Tanaka, Kouta; Kobayashi, Fuminori

    PLL-MSC (Phase Locked Loop Motor Speed Control) systems can completely reject speed error and steady-state phase error for constant-speed input signals. However, it is not usually applied to systems with inputs including acceleration, because they have poor tracking speed and strange pull-in behavior. In the field of radio communication, “dual-loop PLL” is very effective for such signals. It can not only enable high-speed tracking, but also cancel phase error. In the digital implementation of the PLL-MSC, it can achive easily by inserting loop filters into both feed back paths, and employed a special adder in PWM to implement loop addition for the two phase detector outputs. The scheme was implemented by programming an FPGA, and satisfiable results were obtained.

  10. Preliminary results of Linear Induction Accelerator LIA-200

    NASA Astrophysics Data System (ADS)

    Sharma, Archana; Senthil, K.; Praveen Kumar, D. D.; Mitra, S.; Sharma, V.; Patel, A.; Sharma, D. K.; Rehim, R.; Kolge, T. S.; Saroj, P. C.; Acharya, S.; Amitava, Roy; Rakhee, M.; Nagesh, K. V.; Chakravarthy, D. P.

    2010-05-01

    Repetitive Pulsed Power Technology is being developed keeping in mind the potential applications of this technology in material modifications, disinfections of water, timber, and food pasteurization etc. BARC has indigenously developed a Linear Induction Accelerator (LIA-200) rated for 200 kV, 4 kA, 100 ns, 10 Hz. The satisfactory performance of all the sub-systems including solid state power modulator, amorphous core based pulsed transformers, magnetic switches, water capacitors, water pulse- forming line, induction adder and field-emission diode have been demonstrated. This paper presents some design details and operational results of this pulsed power system. It also highlights the need for further research and development to build reliable and economic high-average power systems for industrial applications.

  11. Design and implementation in VHDL code of the two-dimensional fast Fourier transform for frequency filtering, convolution and correlation operations

    NASA Astrophysics Data System (ADS)

    Vilardy, Juan M.; Giacometto, F.; Torres, C. O.; Mattos, L.

    2011-01-01

    The two-dimensional Fast Fourier Transform (FFT 2D) is an essential tool in the two-dimensional discrete signals analysis and processing, which allows developing a large number of applications. This article shows the description and synthesis in VHDL code of the FFT 2D with fixed point binary representation using the programming tool Simulink HDL Coder of Matlab; showing a quick and easy way to handle overflow, underflow and the creation registers, adders and multipliers of complex data in VHDL and as well as the generation of test bench for verification of the codes generated in the ModelSim tool. The main objective of development of the hardware architecture of the FFT 2D focuses on the subsequent completion of the following operations applied to images: frequency filtering, convolution and correlation. The description and synthesis of the hardware architecture uses the XC3S1200E family Spartan 3E FPGA from Xilinx Manufacturer.

  12. Conceptual design for a linear-transformer driver (LTD)-based refurbishment and upgrade of the Saturn accelerator pulse-power system.

    SciTech Connect

    Mazarakis, Michael Gerrassimos; Struve, Kenneth William

    2006-09-01

    The purpose of this work was to develop a conceptual design for the Saturn accelerator using the modular Liner-Transformer Driver (LTD) technology to identify risks and to focus development and research for this new technology. We present a reference design for a Saturn class driver based on a number of linear inductive voltage adders connected in parallel. This design is very similar to a design reported five years ago [1]. However, with the design reported here we use 1-MA, 100-kV LTD cavities as building blocks. These cavities have already been built and are currently in operation at the HCEI in Tomsk, Russia [2]. Therefore, this new design integrates already-proven individual components into a full system design.

  13. VLSI processors for signal detection in SETI.

    PubMed

    Duluk, J F; Linscott, I R; Peterson, A M; Burr, J; Ekroot, B; Twicken, J

    1989-01-01

    The objective of the Search for Extraterrestrial Intelligence (SETI) is to locate an artificially created signal coming from a distant star. This is done in two steps: (1) spectral analysis of an incoming radio frequency band, and (2) pattern detection for narrow-band signals. Both steps are computationally expensive and require the development of specially designed computer architectures. To reduce the size and cost of the SETI signal detection machine, two custom VLSI chips are under development. The first chip, the SETI DSP Engine, is used in the spectrum analyzer and is specially designed to compute Discrete Fourier Transforms (DFTs). It is a high-speed arithmetic processor that has two adders, one multiplier-accumulator, and three four-port memories. The second chip is a new type of Content-Addressable Memory. It is the heart of an associative processor that is used for pattern detection. Both chips incorporate many innovative circuits and architectural features. PMID:11537749

  14. Development of venom toxin-specific antibodies by DNA immunisation: rationale and strategies to improve therapy of viper envenoming.

    PubMed

    Harrison, R A

    2004-04-16

    DNA vaccination induces potent cellular immune responses against infectious and parasitic intracellular pathogens. This paper illustrates that DNA immunisation protocols can be adapted to induce high titre antibody responses with potential to improve the treatment of systemic snake envenoming that kills 20000 people annually in Africa. Envenoming by the saw-scaled vipers and puff adders are responsible for the majority of these deaths. DNA sequences encoding haemorrhagic, pro- and anti-coagulant and other haemostasis-disruptive venom toxins from these vipers showed extensive cross-specific and cross-generic sequence and structural similarities. The predicted antigenic profiles of these toxin sequences are utilised to design DNA immunisation constructs to generate toxin-specific antibodies with potential to polyspecifically neutralise venoms from the most medically-important African vipers. PMID:15068847

  15. An MHD generator energy flow time rate extremal controlling system

    SciTech Connect

    Vasiliev, V.V.

    1993-12-31

    The progress in the development and studying of new methods of producing electric energy, based on direct conversion of heat energy, raises the problem of more effective use of their power characteristics. Disclosure is made of a self-optimizing control system for an object with a unimodal quality function. The system comprises an object, a divider, a band-pass filter, an averaging filter, a multiplier, a final control element, an adder and further includes a search signal generator. The fashion and the system are presented in the USSR No. 684510, in the USA No. 4179730, in France No. 2386854, In Germany No. 2814963, in Japan No. 1369882. The progress in the development and studying of new method of producing electric energy, based on direct conversion of heat in MHD generator into electric energy, raises the problem of more effective use of their power characteristics.

  16. Development of ferrite logic devices for an arithmetic processor

    NASA Technical Reports Server (NTRS)

    Heckler, C. H., Jr.

    1972-01-01

    A number of fundamentally ultra-reliable, all-magnetic logic circuits are developed using as a basis a single element ferrite structure wired as a logic delay element. By making minor additions or changes to the basic wiring pattern of the delay element other logic functions such as OR, AND, NEGATION, MAJORITY, EXCLUSIVE-OR, and FAN-OUT are developed. These logic functions are then used in the design of a full-adder, a set/reset flip-flop, and an edge detector. As a demonstration of the utility of all the developed devices, an 8-bit, all-magnetic, logic arithmetic unit capable of controlled addition, subtraction, and multiplication is designed. A new basic ferrite logic element and associated complementary logic scheme with the potential of improved performance is also described. Finally, an improved batch process for fabricating joint-free power drive and logic interconnect conductors for this basic class of all-magnetic logic is presented.

  17. Hardware-efficient low-power 2-bit ternary ALU design in CNTFET technology

    NASA Astrophysics Data System (ADS)

    Lata Murotiya, Sneh; Gupta, Anu

    2016-05-01

    This paper proposes a hardware-efficient low-power 2-bit ternary arithmetic logic unit (TALU) design in carbon nano tube field effect transistor technology. The proposed TALU architecture combines adder-subtractor and Ex-OR cell in one cell, thereby reducing the number of transistors by 71% in comparison with other TALU architecture. Further, the proposed TALU is optimised at transistor level with a new pass-transistor logic-based encoder circuit. Hspice simulation results show that the proposed design attains great advantages in power and power-delay product for addition and multiplication operations than reported designs. For instant, at power supply of 0.9 V, the proposed TALU consumes on average 91% and 95% less energy compared to their existing counterparts, for addition and multiplication operations, respectively.

  18. Large-area formation of self-aligned crystalline domains of organic semiconductors on transistor channels using CONNECT

    PubMed Central

    Park, Steve; Giri, Gaurav; Shaw, Leo; Pitner, Gregory; Ha, Jewook; Koo, Ja Hoon; Gu, Xiaodan; Park, Joonsuk; Lee, Tae Hoon; Nam, Ji Hyun; Hong, Yongtaek; Bao, Zhenan

    2015-01-01

    The electronic properties of solution-processable small-molecule organic semiconductors (OSCs) have rapidly improved in recent years, rendering them highly promising for various low-cost large-area electronic applications. However, practical applications of organic electronics require patterned and precisely registered OSC films within the transistor channel region with uniform electrical properties over a large area, a task that remains a significant challenge. Here, we present a technique termed “controlled OSC nucleation and extension for circuits” (CONNECT), which uses differential surface energy and solution shearing to simultaneously generate patterned and precisely registered OSC thin films within the channel region and with aligned crystalline domains, resulting in low device-to-device variability. We have fabricated transistor density as high as 840 dpi, with a yield of 99%. We have successfully built various logic gates and a 2-bit half-adder circuit, demonstrating the practical applicability of our technique for large-scale circuit fabrication. PMID:25902502

  19. New architecture of fast parallel multiplier using fast parallel counter with FPA (first partial product addition)

    NASA Astrophysics Data System (ADS)

    Lee, Mike M.; Cho, Byung Lok

    2001-11-01

    In this paper, we proposed a new First Partial product Addition (FPA) architecture with new compressor (or parallel counter) to CSA tree built in the process of adding partial product for improving speed in the fast parallel multiplier to improve the speed of calculating partial product by about 20% compared with existing parallel counter using full Adder. The new circuit reduces the CLA bit finding final sum by N/2 using the novel FPA architecture. A 5.14ns of multiplication speed of the 16X16 multiplier is obtained using 0.25um CMOS technology. The architecture of the multiplier is easily opted for pipeline design and demonstrates high speed performance.

  20. Adiabatic quantum-flux-parametron cell library adopting minimalist design

    NASA Astrophysics Data System (ADS)

    Takeuchi, Naoki; Yamanashi, Yuki; Yoshikawa, Nobuyuki

    2015-05-01

    We herein build an adiabatic quantum-flux-parametron (AQFP) cell library adopting minimalist design and a symmetric layout. In the proposed minimalist design, every logic cell is designed by arraying four types of building block cells: buffer, NOT, constant, and branch cells. Therefore, minimalist design enables us to effectively build and customize an AQFP cell library. The symmetric layout reduces unwanted parasitic magnetic coupling and ensures a large mutual inductance in an output transformer, which enables very long wiring between logic cells. We design and fabricate several logic circuits using the minimal AQFP cell library so as to test logic cells in the library. Moreover, we experimentally investigate the maximum wiring length between logic cells. Finally, we present an experimental demonstration of an 8-bit carry look-ahead adder designed using the minimal AQFP cell library and demonstrate that the proposed cell library is sufficiently robust to realize large-scale digital circuits.

  1. Collision-Based Computing Using Single-Electron Circuits

    NASA Astrophysics Data System (ADS)

    Hayashi, Shunsuke; Oya, Takahide

    2012-06-01

    A single-electron (SE) device based on “collision-based computing (CBC)” is proposed for information processing. CBC is an analog computing in which input signals behave like billiard balls, and the goals of moving balls are regarded as output positions. The proposed SE device consists of arrayed SE oscillators with coupling capacitor between each pair. An SE oscillator is a threshold decision device which can be used as a reaction-diffusion (RD) model, a kind of the analog computation model. The RD model can express the various behaviors of an excited wave, e.g., “moving at a constant velocity” and “disappearing due to collision”. These behaviors are also important for CBC. We designed basic SE-CBC circuits and a full adder as an application, and evaluated their operation by Monte-Carlo computer simulation. The results indicate that this circuit is useful for configuring various types of logical circuits.

  2. Evolutionary Based Techniques for Fault Tolerant Field Programmable Gate Arrays

    NASA Technical Reports Server (NTRS)

    Larchev, Gregory V.; Lohn, Jason D.

    2006-01-01

    The use of SRAM-based Field Programmable Gate Arrays (FPGAs) is becoming more and more prevalent in space applications. Commercial-grade FPGAs are potentially susceptible to permanently debilitating Single-Event Latchups (SELs). Repair methods based on Evolutionary Algorithms may be applied to FPGA circuits to enable successful fault recovery. This paper presents the experimental results of applying such methods to repair four commonly used circuits (quadrature decoder, 3-by-3-bit multiplier, 3-by-3-bit adder, 440-7 decoder) into which a number of simulated faults have been introduced. The results suggest that evolutionary repair techniques can improve the process of fault recovery when used instead of or as a supplement to Triple Modular Redundancy (TMR), which is currently the predominant method for mitigating FPGA faults.

  3. Integrated logic circuits using single-atom transistors.

    PubMed

    Mol, J A; Verduijn, J; Levine, R D; Remacle, F; Rogge, S

    2011-08-23

    Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. Single-atom transistors, SATs, cascaded in a circuit are proposed as a promising route that is compatible with existing technology. We demonstrate the use of quantum degrees of freedom to perform logic operations in a complementary-metal-oxide-semiconductor device. Each SAT performs multilevel logic by electrically addressing the electronic states of a dopant atom. A single electron transistor decodes the physical multivalued output into the conventional binary output. A robust scalable circuit of two concatenated full adders is reported, where by utilizing charge and quantum degrees of freedom, the functionality of the transistor is pushed far beyond that of a simple switch. PMID:21808050

  4. Retrofit costs for lime/limestone FGD and lime spray drying at coal-fired utility boilers

    SciTech Connect

    Emmel, T.E.; Jones, J.W.

    1990-01-01

    The paper gives results of a research program the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 controls to existing coal-fired utility boilers. The costs of retrofitting conventional lime/limestone wet flue gas desulfurization (L/LS FGD) and lime spray drying (LSD) FGD at 100-200 coal-fired power plants are being estimated under this program. The retrofit capital cost estimating procedures used for L/LS FGD and LSD FGD make two cost adjustments to current procedures used to estimate FGD costs: cost adders (for items not normally included in FGD system costs; e.g., demolition and relocation of existing facilities) and cost multipliers (to adjust capital costs for site access, congestion, and underground obstructions).

  5. ASIC design of a digital fuzzy system on chip for medical diagnostic applications.

    PubMed

    Roy Chowdhury, Shubhajit; Roy, Aniruddha; Saha, Hiranmay

    2011-04-01

    The paper presents the ASIC design of a digital fuzzy logic circuit for medical diagnostic applications. The system on chip under consideration uses fuzzifier, memory and defuzzifier for fuzzifying the patient data, storing the membership function values and defuzzifying the membership function values to get the output decision. The proposed circuit uses triangular trapezoidal membership functions for fuzzification patients' data. For minimizing the transistor count, the proposed circuit uses 3T XOR gates and 8T adders for its design. The entire work has been carried out using TSMC 0.35 µm CMOS process. Post layout TSPICE simulation of the whole circuit indicates a delay of 31.27 ns and the average power dissipation of the system on chip is 123.49 mW which indicates a less delay and less power dissipation than the comparable embedded systems reported earlier. PMID:20703567

  6. An efficient FPGA architecture for integer ƞth root computation

    NASA Astrophysics Data System (ADS)

    Rangel-Valdez, Nelson; Barron-Zambrano, Jose Hugo; Torres-Huitzil, Cesar; Torres-Jimenez, Jose

    2015-10-01

    In embedded computing, it is common to find applications such as signal processing, image processing, computer graphics or data compression that might benefit from hardware implementation for the computation of integer roots of order ?. However, the scientific literature lacks architectural designs that implement such operations for different values of N, using a low amount of resources. This article presents a parameterisable field programmable gate array (FPGA) architecture for an efficient Nth root calculator that uses only adders/subtractors and ? location memory elements. The architecture was tested for different values of ?, using 64-bit number representation. The results show a consumption up to 10% of the logical resources of a Xilinx XC6SLX45-CSG324C device, depending on the value of N. The hardware implementation improved the performance of its corresponding software implementations in one order of magnitude. The architecture performance varies from several thousands to seven millions of root operations per second.

  7. A superconducting-nanowire three-terminal electrothermal device.

    PubMed

    McCaughan, Adam N; Berggren, Karl K

    2014-10-01

    Superconducting electronics based on Josephson junctions are used to sense and process electronic signals with minimal loss; however, they are ultrasensitive to magnetic fields, limited in their amplification capabilities, and difficult to manufacture. We have developed a 3-terminal, nanowire-based superconducting electrothermal device which has no Josephson junctions. This device, which we call the nanocryotron, can be patterned from a single thin film of superconducting material with conventional electron-beam lithography. The nanocryotron has a demonstrated gain of >20, can drive impedances of 100 kΩ, and operates in typical ambient magnetic fields. We have additionally applied it both as a digital logic element in a half-adder circuit, and as a digital amplifier for superconducting nanowire single-photon detectors pulses. The nanocryotron has immediate applications in classical and quantum communications, photon sensing, and astronomy, and its input characteristics are suitable for integration with existing superconducting technologies. PMID:25233488

  8. VLSI processors for signal detection in SETI

    NASA Astrophysics Data System (ADS)

    Duluk, J. F.; Linscott, I. R.; Peterson, A. M.; Burr, J.; Ekroot, B.; Twicken, J.

    The objective of the Search for Extraterrestrial Intelligence (SETI) is to locate an artifically created signal coming from a distant star. This is done in two steps: (1) spectral analysis of an incoming radio frequency band, and (2) pattern detection for narrow-band signals. Both steps are computationally expensive and require the development of specially designed computer architectures. To reduce the size and cost of the SETI signal detection machine, two custom VLSI chips are under development. The first chip, the SETI DSP Engine, is used in the spectrum analyzer and is specially designed to compute Discrete Fourier Transforms (DFTs). It is a high-speed arithmetic processor that has two adders, one multiplier-accumulator, and three four-port memories. The second chip is a new type of Content-Addressable Memory. It is the heart of an associative processor that is used for pattern detection. Both chips incoporate many innovative circuits and architectural features.

  9. Neural Chip SAND in online data processing of extensive air showers

    NASA Astrophysics Data System (ADS)

    Eppler, W.; Fischer, T.; Gemmeke, H.; Chilingarian, A.; Vardanyan, A.

    2000-04-01

    The neural chip SAND (Simple Applicable Neural Device) was designed to accelerate computations of neural networks at a very low cost basis, due to the fact that only few peripheral chips are necessary to use the neural network chip in applications. Four SAND-chips were implemented on one PCI-board. The board is highly usable for hardware triggers in particle physics. The performance of a SAND-PCI-board is 800 Mega Connections per Second due to four neuro-chips, each with four parallel 16 bit multipliers and 40 bit adders. SAND is able to implement feedforward neural networks with a maximum of 512 input neurons and three hidden layers. Kohonen feature maps and radial basis function networks may be also calculated. The application of the SAND-PCI-board is proposed for cosmic ray physics to allow online analysis of extensive air showers.

  10. Note: Design and initial results of a multi-pulsed intense electron beam source

    NASA Astrophysics Data System (ADS)

    Xia, L.; Zhang, H.; Yang, A.; Shen, Y.; Wang, W.; Wen, L.; Zhang, K.; Shi, J.; Zhang, L.; Deng, J.

    2014-06-01

    A multi-pulsed intense electron beam source is introduced, including the design and the initial experimental results. The source can generate a burst of three pulses of intense electron beams with energy of 2-3 MeV and beam intensities of around 2.5 kA. An inductive adder is chosen to generate the pulsed diode voltages and a dispenser cathode is chosen to emit electron beams. The test results indicate that the design of the source is reliable. The multi-pulsed diode voltage is up to 2.5 MV and the beam intensities are more than 2 kA at the exit of the source with small variation.

  11. Note: Design and initial results of a multi-pulsed intense electron beam source.

    PubMed

    Xia, L; Zhang, H; Yang, A; Shen, Y; Wang, W; Wen, L; Zhang, K; Shi, J; Zhang, L; Deng, J

    2014-06-01

    A multi-pulsed intense electron beam source is introduced, including the design and the initial experimental results. The source can generate a burst of three pulses of intense electron beams with energy of 2-3 MeV and beam intensities of around 2.5 kA. An inductive adder is chosen to generate the pulsed diode voltages and a dispenser cathode is chosen to emit electron beams. The test results indicate that the design of the source is reliable. The multi-pulsed diode voltage is up to 2.5 MV and the beam intensities are more than 2 kA at the exit of the source with small variation. PMID:24985872

  12. Virtual gap dielectric wall accelerator

    SciTech Connect

    Caporaso, George James; Chen, Yu-Jiuan; Nelson, Scott; Sullivan, Jim; Hawkins, Steven A

    2013-11-05

    A virtual, moving accelerating gap is formed along an insulating tube in a dielectric wall accelerator (DWA) by locally controlling the conductivity of the tube. Localized voltage concentration is thus achieved by sequential activation of a variable resistive tube or stalk down the axis of an inductive voltage adder, producing a "virtual" traveling wave along the tube. The tube conductivity can be controlled at a desired location, which can be moved at a desired rate, by light illumination, or by photoconductive switches, or by other means. As a result, an impressed voltage along the tube appears predominantly over a local region, the virtual gap. By making the length of the tube large in comparison to the virtual gap length, the effective gain of the accelerator can be made very large.

  13. Treatment of Solar Generation in Electric Utility Resource Planning (Presentation)

    SciTech Connect

    Cory, K.; Sterling, J.; Taylor, M.; McLaren, J.

    2014-01-01

    Today's utility planners have a different market and economic context than their predecessors, including planning for the growth of renewable energy. Through interviews and a questionnaire, the authors gathered information on utility supply planning and how solar is represented. Utilities were asked to provide their resource planning process details, key assumptions (e.g. whether DG is represented as supply or negative load), modeling methodology (e.g. type of risk analytics and candidate portfolio development), capacity expansion and production simulation model software, and solar project representation (project size, capacity value and integration cost adder). This presentation aims to begin the exchange of information between utilities, regulators and other stakeholders by capturing utility-provided information about: 1) how various utilities approach long-range resource planning; 2) methods and tools utilities use to conduct resource planning; and, 3) how solar technologies are considered in the resource planning process.

  14. Parallel implementation of VHDL simulations on the Intel iPSC/2 hypercube. Master's thesis

    SciTech Connect

    Comeau, R.C.

    1991-12-01

    VHDL models are executed sequentially in current commercial simulators. As chip designs grow larger and more complex, simulations must run faster. One approach to increasing simulation speed is through parallel processors. This research transforms the behavioral and structural models created by Intermetrics' sequential VHDL simulator into models for parallel execution. The models are simulated on an Intel iPSC/2 hypercube with synchronization of the nodes being achieved by utilizing the Chandy Misra paradigm for discrete-event simulations. Three eight-bit adders, the ripple carry, the carry save, and the carry-lookahead, are each run through the parallel simulator. Simulation time is cut in at least half for all three test cases over the sequential Intermetrics model. Results with regard to speedup are given to show effects of different mappings, varying workloads per node, and overhead due to output messages.

  15. Implementation of a pulse coupled neural network in FPGA.

    PubMed

    Waldemark, J; Millberg, M; Lindblad, T; Waldemark, K; Becanovic, V

    2000-06-01

    The Pulse Coupled neural network, PCNN, is a biologically inspired neural net and it can be used in various image analysis applications, e.g. time-critical applications in the field of image pre-processing like segmentation, filtering, etc. a VHDL implementation of the PCNN targeting FPGA was undertaken and the results presented here. The implementation contains many interesting features. By pipelining the PCNN structure a very high throughput of 55 million neuron iterations per second could be achieved. By making the coefficients re-configurable during operation, a complete recognition system could be implemented on one, or maybe two, chip(s). Reconsidering the ranges and resolutions of the constants may save a lot of hardware, since the higher resolution requires larger multipliers, adders, memories etc. PMID:11011789

  16. Analog to digital converter for two-dimensional radiant energy array computers

    NASA Technical Reports Server (NTRS)

    Shaefer, D. H.; Strong, J. P., III (Inventor)

    1977-01-01

    The analog to digital converter stage derives a bit array of digital radiant energy signals representative of the amplitudes of an input radiant energy analog signal array and derives an output radiant energy analog signal array to serve as an input to succeeding stages. The converter stage includes a digital radiant energy array device which contains radiant energy array positions so that the analog array is less than a predetermined threshold level. A scaling device amplifies the radiant signal levels of the input array and the digital array so that the radiant energy signal level carried by the digital array corresponds to the threshold level. An adder device adds the signals of the scaled input and digital arrays at corresponding array positions to form the output analog array.

  17. Modern optical signal processing experiments demonstrating intensity and pulse-width modulation using an acousto-optic modulator

    NASA Astrophysics Data System (ADS)

    Poon, Ting-Chung; McNeill, Mark D.; Moore, Daniel J.

    1997-09-01

    Two experiments are presented to introduce undergraduate students in electrical engineering or physics to modern optical signal processing. Both experiments use an acousto-optic (AO) Bragg cell together with additional electronics to modify the intensity of a laser beam. Specifically, we show how an AO feedback system operating in the Bragg regime can be configured to produce amplitude modulated (AM) and pulse-width modulated optical signals. The basic components of the AO feedback system include a laser, an AO Bragg cell, an electronic AM modulator, a photodetector, an amplifier, and an electronic adder. Except for the laser, the AM modulator, and the Bragg cell, each of these components can be constructed with low cost electronics. A tutorial outlining the principles of acousto-optics is included to provide sufficient understanding of the Bragg cell. The project described in the paper has been used as a demonstration for junior- and senior-level undergraduate students in electrical engineering communications and optics classes.

  18. A multifunctional arithmetical processor model integrated inside a single molecule.

    PubMed

    Liu, Yu; Jiang, Wei; Zhang, Heng-Yi; Li, Chun-Ju

    2006-07-27

    Improving the processing power of molecules remains the challenge for molecular logic and computation. Here we report a 2-phenylimidazo[4,5-f][1,10]phenanthroline (PIPH)-based three-state molecular switch by controlling its unique emission and absorption spectra in the acid and base condition. On one hand, PIPH can perform simultaneously the functions of an "AND" gate and an "XOR" gate, capable of operating as a half-adder, and the "off-on-off" function as well as comparison function by monitoring its fluorescent spectral changes. On the other hand, the molecule can also implement in parallel the functions of an "XOR" gate and two "INH" gates by monitoring its absorption spectral changes, which constructs two half-subtractors. The cooperative operation of comparator and half-subtractor makes general subtraction operation become possible, which is discussed conceptually in the report. PMID:16854125

  19. The Current Status of the LLNL Recirculator

    NASA Astrophysics Data System (ADS)

    Ahle, L.; Sangster, T. C.; Barnard, J.; Craig, G.; Friedman, A.; Grote, D. P.; Halaxa, E.; Hanks, R. L.; Hernandez, M.; Kirbie, H. C.; Logan, B. G.; Lund, S. M.; Mant, G.; Molvik, A. W.; Sharp, W. M.; Williams, C.; Debeling, A.; Fritz, W.; Burkhart, C.

    1999-11-01

    The Heavy Ion Fusion Group at Lawrence Livermore National Laboratory has for several years been developing the world’s first circular induction accelerator designed for space charge dominated ion beams. Currently, the machine extends to 90 degrees, or 10 half-lattice periods (HLP) with induction cores for acceleration placed on every other HLP. Beam acceleration using an inductive adder circuit to pulse the induction cores was recently achieved with no adverse effects on the beam quality. In addition, a pulser to ramp the dipole plates was also implemented. The effect of these two systems can be clearly seen by changes in transverse charge centroid positions as measured by the Capacitve Beam Probes. Data from this system and other diagnostics will be presented.

  20. Active Detection of Shielded Special Nuclear Material in the Presence of Variable High Backgrounds Using a Mixed Photon-Neutron Source

    NASA Astrophysics Data System (ADS)

    Martin, Philip N.; Clemett, Ceri D.; Hill, Cassie; O'Malley, John; Campbell, Ben

    This paper describes and compares two approaches to the analysis of active interrogation data containing high photon backgrounds associated with mixed photon-neutron source flash active interrogation. Results from liquid scintillation detectors (EJ301/EJ309) fielded at the Naval Research Laboratory (NRL), in collaboration with the Atomic Weapons Establishment (AWE), using the NRL Mercury Inductive Voltage Adder (IVA) operating in both a photon and mixed photon-neutron mode at a Depleted Uranium (DU) target are presented. The standard approach applying a Figure of Merit (FOM) consisting of background sigma above background is compared with an approach looking to fit only the time-decaying photon signal with standard delayed photon emission from ∼10-MeV end-point-energy Bremsstrahlung photofission of DU. Examples where each approach does well and less well are presented together with a discussion of the relative limitations of both approaches to the type of mixed photon-neutron flash active interrogation being considered.

  1. Adiabatic quantum-flux-parametron cell library adopting minimalist design

    SciTech Connect

    Takeuchi, Naoki; Yamanashi, Yuki; Yoshikawa, Nobuyuki

    2015-05-07

    We herein build an adiabatic quantum-flux-parametron (AQFP) cell library adopting minimalist design and a symmetric layout. In the proposed minimalist design, every logic cell is designed by arraying four types of building block cells: buffer, NOT, constant, and branch cells. Therefore, minimalist design enables us to effectively build and customize an AQFP cell library. The symmetric layout reduces unwanted parasitic magnetic coupling and ensures a large mutual inductance in an output transformer, which enables very long wiring between logic cells. We design and fabricate several logic circuits using the minimal AQFP cell library so as to test logic cells in the library. Moreover, we experimentally investigate the maximum wiring length between logic cells. Finally, we present an experimental demonstration of an 8-bit carry look-ahead adder designed using the minimal AQFP cell library and demonstrate that the proposed cell library is sufficiently robust to realize large-scale digital circuits.

  2. Design of Application-Specific Instructions and Hardware Accelerator for Reed-Solomon Codecs

    NASA Astrophysics Data System (ADS)

    Lee, Jung H.; Lee, Jaesung; Sunwoo, Myung H.

    2003-12-01

    This paper presents new application-specific digital signal processor (ASDSP) instructions and their hardware accelerator to efficiently implement Reed-Solomon (RS) encoding and decoding, which is one of the most widely used forward error control (FEC) algorithms. The proposed ASDSP architecture can implement various programmable primitive polynomials, and thus, hardwired RS codecs can be replaced. The new instructions and their hardware accelerator perform Galois field (GF) operations using the proposed GF multiplier and adder. Therefore, the proposed digital signal processor (DSP) architecture can significantly reduce the number of clock cycles compared with existing DSP chips. The proposed GF multiplier was implemented using the Faraday 0.25[InlineEquation not available: see fulltext.]m standard cell library and it can perform RS decoding at a rate up to 228.1 Mbps at 130 MHz.

  3. Multi-Agent Methods for the Configuration of Random Nanocomputers

    NASA Technical Reports Server (NTRS)

    Lawson, John W.

    2004-01-01

    As computational devices continue to shrink, the cost of manufacturing such devices is expected to grow exponentially. One alternative to the costly, detailed design and assembly of conventional computers is to place the nano-electronic components randomly on a chip. The price for such a trivial assembly process is that the resulting chip would not be programmable by conventional means. In this work, we show that such random nanocomputers can be adaptively programmed using multi-agent methods. This is accomplished through the optimization of an associated high dimensional error function. By representing each of the independent variables as a reinforcement learning agent, we are able to achieve convergence must faster than with other methods, including simulated annealing. Standard combinational logic circuits such as adders and multipliers are implemented in a straightforward manner. In addition, we show that the intrinsic flexibility of these adaptive methods allows the random computers to be reconfigured easily, making them reusable. Recovery from faults is also demonstrated.

  4. Ground-state spin logic

    NASA Astrophysics Data System (ADS)

    Whitfield, J. D.; Faccin, M.; Biamonte, J. D.

    2012-09-01

    Designing and optimizing cost functions and energy landscapes is a problem encountered in many fields of science and engineering. These landscapes and cost functions can be embedded and annealed in experimentally controllable spin Hamiltonians. Using an approach based on group theory and symmetries, we examine the embedding of Boolean logic gates into the ground-state subspace of such spin systems. We describe parameterized families of diagonal Hamiltonians and symmetry operations which preserve the ground-state subspace encoding the truth tables of Boolean formulas. The ground-state embeddings of adder circuits are used to illustrate how gates are combined and simplified using symmetry. Our work is relevant for experimental demonstrations of ground-state embeddings found in both classical optimization as well as adiabatic quantum optimization.

  5. Ground State Spin Logic

    NASA Astrophysics Data System (ADS)

    Whitfield, James; Faccin, Mauro; Biamonte, Jacob

    2013-03-01

    Designing and optimizing cost functions and energy landscapes is a problem encountered in many fields of science and engineering. These landscapes and cost functions can be embedded and annealed in experimentally controllable spin Hamiltonians. Using an approach based on group theory and symmetries, we examine the embedding of Boolean logic gates into the ground-state subspace of such spin systems. We describe parameterized families of diagonal Hamiltonians and symmetry operations which preserve the ground-state subspace encoding the truth tables of Boolean formulas. The ground-state embeddings of adder circuits are used to illustrate how gates are combined and simplified using symmetry. Our work is relevant for experimental demonstrations of ground-state embeddings found in both classical optimization as well as adiabatic quantum optimization.

  6. Power optimization in logic isomers

    NASA Technical Reports Server (NTRS)

    Panwar, Ramesh; Rennels, David; Alkalaj, Leon

    1993-01-01

    Logic isomers are labeled, 2-isomorphic graphs that implement the same logic function. Logic isomers may have significantly different power requirements even though they have the same number of transistors in the implementation. The power requirements of the isomers depend on the transition activity of the input signals. The power requirements of isomorphic graph isomers of n-input NAND and NOR gates are shown. Choosing the less power-consuming isomer instead of the others can yield significant power savings. Experimental results on a ripple-carry adder are presented to show that the implementation using the least power-consuming isomers requires approximately 10 percent less power than the implementation using the most power-consuming isomers. Simulations of other random logic designs also confirm that designs using less power-consuming isomers can reduce the logic power demand by approximately 10 percent as compared to designs using more power-consuming isomers.

  7. A two-dimensional advanced systolic array and its arithmetic architecture and design

    SciTech Connect

    Jun, M.S.

    1989-01-01

    The rapid advances in the very large scale integrated (VLSI) technology has created a flurry of research in designing future computer architectures. Many methods have been developed for parallel processing of algorithms by directly mapping them onto parallel architectures. We present new methodologies for design of systolic arrays and asynchronous arrays that implement recursive algorithms efficiently. Using the new methods, we develop a systolic array with very simple local interconnection for matrix multiplication which achieves optimal performance without using any undesirable properties such as preloading input data or global broadcasting. We prove the correctness of the matrix multiplication algorithms on the systolic array with space-time parameters. The implementations of the algorithms can be easily proved and can be systolically expanded. We also develop a multi-purpose built-in logic for asynchronous self-test (BLAST) modules in processing elements. An asynchronous array for matrix multiplication which can speed up the total computation time significantly is also presented. To demonstrate the power of the proposed systolic array, the array will be applied to the shortest path problem by using the partitioned mapping approach which will be the key to extend the computational capacity of VLSI architectures with fixed size. The utilization of partitioning algorithms can overcome difficulties in the management of a large-size graph. To achieve the highest possible computation speed of the systolic array, we develop a prefix carry-lookahead adder/subtractor which achieves the maximal possible parallelism. The new carry-lookahead design leads to a high-speed adders/subtractors with regular layout. The time complexity is 2log{sub 2}n - 1 while the Brent-Kung's scheme has 4log{sub 2}n.

  8. Design of a 5-MA 100-ns linear-transformer-driver accelerator for wire array Z-pinch experiments

    NASA Astrophysics Data System (ADS)

    Zhou, Lin; Li, Zhenghong; Wang, Zhen; Liang, Chuan; Li, Mingjia; Qi, Jianmin; Chu, Yanyun

    2016-03-01

    The linear-transformer-driver (LTD) is a recently developed pulsed-power technology that shows great promise for a number of applications. These include a Z -pinch-driven fission-fusion-hybrid reactor that is being developed by the Chinese Academy of Engineering Physics. In support of the reactor development effort, we are planning to build an LTD-based accelerator that is optimized for driving wire-array Z -pinch loads. The accelerator comprises six modules in parallel, each of which has eight series 0.8-MA LTD cavities in a voltage-adder configuration. Vacuum transmission lines are used from the interior of the adder to the central vacuum chamber where the load is placed. Thus the traditional stack-flashover problem is eliminated. The machine is 3.2 m tall and 12 m in outer diameter including supports. A prototype cavity was built and tested for more than 6000 shots intermittently at a repetition rate of 0.1 Hz. A novel trigger, in which only one input trigger pulse is needed by utilizing an internal trigger brick, was developed and successfully verified in these shots. A full circuit modeling was conducted for the accelerator. The simulation result shows that a current pulse rising to 5.2 MA in 91 ns (10%-90%) can be delivered to the wire-array load, which is 1.5 cm in height, 1.2 cm in initial radius, and 1 mg in mass. The maximum implosion velocity of the load is 32 cm /μ s when compressed to 0.1 of the initial radius. The maximum kinetic energy is 78 kJ, which is 11.7% of the electric energy stored in the capacitors. This accelerator is supposed to enable a radiation energy efficiency of 20%-30%, providing a high efficient facility for research on the fast Z pinch and technologies for repetition-rate-operated accelerators.

  9. Performance analysis of pseudo 4-phase dual-rail asynchronous protocol

    NASA Astrophysics Data System (ADS)

    Santhi, M.; Sarangan, Siddharth; Murali, K.; Lakshminarayanan, G.

    2012-08-01

    This article presents the performance analysis of novel pseudo 4-phase dual-rail protocol with self-reset and multiple-reset logic for high speed asynchronous applications. The self-reset logic eliminates the need for separate empty phase and hence reduces the number of transitions at the input and the output. The multiple-reset logic reduces the reset phase and hence increases the throughput. The performance of the pseudo 4-phase dual-rail protocol is compared with the existing 4-phase dual-rail protocol by implementing 8-bit and 16-bit asynchronously pipelined carry look ahead adders (CLA) in 0.35 µm technology. The time period decreases up to 32.58% and 35.93% respectively, the reset phase reduces up to 66.39% and 76.18%, respectively, and the operating frequency increases up to 48.4% and 56.2%, respectively, for 8- and 16-bit CLA adders with the pseudo 4-phase dual-rail protocol compared to the conventional 4-phase dual-rail protocol at the cost of increase in area of 8.8% and 3.3%, respectively. The delay-power product in ns-mW of the 8- and 16-bit CLAs is reduced at the maximum of 11.29% and 23.74%, respectively, with the pseudo 4-phase dual-rail protocol compared to the conventional 4-phase dual-rail protocol. The pseudo 4-phase dual-rail protocol is suitable for interfacing with synchronous environments.

  10. Issues and methods in incorporating environmental externalities into the integrated resource planning process

    SciTech Connect

    Fang, J.M.; Galen, P.S.

    1994-11-01

    This report is a review of current practices and policies in considering environmental externalities in the integrated resource planning and performance based regulation (IRP/PBR) process. The following issues are presented and examined: What are the pros and cons of treating environmental externalities in the IRP process? How are potential future environmental regulations being treated? Are externalities being qualitatively or quantitatively considered, or monetized? Are offsets being allowed? How are externality policies being coordinated among different levels and branches of governments? Should environmental externalities be considered in dispatching a utility`s existing resources? What are the procedures for addressing uncertainty in incorporating environmental externalities into IRP? How are externalities valued? What are other approaches to addressing environmental externalities. This report describes seven major approaches for addressing environmental externalities in the IRP process: qualitative treatment, weighting and ranking, cost of control, damage function, percentage adders, monetization by emission, and multiattribute trade-off analysis. The discussion includes a taxonomy of the full range of alternative methods for addressing environmental externalities, a summary of state PUC actions, the role of state laws, the debate on environmental adders, and the choice of methodologies. In addition, this report characterizes the interests of stakeholders such as the electric industry, fuel suppliers, energy consumers, governmental agencies, public interest groups, consultants, and others. It appears that the views, positions, and interests of these stakeholders are affected by their perceptions of the potential impacts on their economic interests or the viability of their position on environmental policy, by the societal perspective they take, and by the orientation of the analysts toward market competition and their respective accumulated expertise.

  11. Phenylalanine-24 in the N-terminal region of ammodytoxins is important for both enzymic activity and presynaptic toxicity.

    PubMed Central

    Petan, Toni; Krizaj, Igor; Gubensek, Franc; Pungercar, Joze

    2002-01-01

    Ammodytoxins (Atxs) are group II phospholipases A(2) (PLA(2)s) with presynaptic toxicity from venom of the snake Vipera ammodytes ammodytes. The molecular basis of their neurotoxicity, and that of similar PLA(2) toxins, is still to be explained. To address this problem, a surface-exposed aromatic residue, Phe(24), in the N-terminal region of the most potent Atx, AtxA, was replaced by other aromatic (tyrosine, tryptophan), hydrophobic (alanine) and polar uncharged (serine, asparagine) residues. The mutants were produced in the bacterial expression system, refolded in vitro and purified to homogeneity. All but the Trp(24) mutant, whose activity was similar to that of the wild type, showed a considerable decrease (40-80%) in enzymic activity on a micellar phosphatidylcholine substrate. This result indicates an important role for the aromatic side chains of phenylalanine or tryptophan, but not tyrosine, in PLA(2) activity, very likely at a stage of interfacial adsorption of the enzyme to zwitterionic aggregated substrates. The substitutions of Phe(24) also significantly decreased toxicity in mice, with the most prominent decrease, of 130-fold, observed in the case of the Asn(24) mutant. The results with the mutants show that there is no correlation between enzymic activity, lethality and binding affinity for three AtxA neuronal receptors (R180, R25 and calmodulin). Our results suggest a critical involvement of Phe(24) in the neurotoxicity of AtxA, apparently at a stage which does not involve the interaction with the known Atx-binding neuronal proteins and catalytic activity. PMID:11931665

  12. Study of Sperm Reproductive Parameters in Mature Zanjani Viper

    PubMed Central

    Moshiri, Malihe; Todehdehghan, Fatemeh; Shiravi, Abdolhossein

    2014-01-01

    Objective Zanjani viper (Vipera albicornuta) is an endemic venomous snake in East Azerbai- jan Province, Iran which is medically important due to its application for antivenin production in the laboratory. We need to produce this snake in captivity. This study was conducted to charac- terize mature male Zanjani viper and to evaluate its sperm reproductive parameters. Materials and Methods This applied- descriptive study was conducted on twenty Zan- jani viper samples collected from Ag Dag Mountain in East Azarbaijan Province, Iran, between September and October 2010. After the snakes were anesthetized and sacrificed humanly, their morphometric specifications and sperm reproductive parameters, including concentration, motility, vitality, morphology, and survival time, were measured. Results Morphometric specifications and evaluation of sperms of the snake showed the following information: Zanjani male viper, body length of 73.65 ± 4.35 cm, tail length of 5.465 ± 0.48 cm, and mature snakes with testicular volumes of 0.61 ± 0.81 ml (right) and of 0.46 ± 0.17 ml (left). Our findings revealed average sperm concen- tration of 0.47 ± 0.1 ×106ml-1, motility of 49 -55 %, vitality of 46.11 ± 9.63 %, normal morphology of 61.71 ± 5.3%, and survival time of 6 ± 2 hours at the laboratory tem- perature. Statistical analyses were performed using Student’s t test for comparison of two values, and one-way ANOVA was applied where three values were compared. Conclusion Results suggest that mature Zanjani male viper with mature sperms in its vas deferens is present in late summer and early autumn seasons in Bostanabad County, Iran. PMID:24567940

  13. Hemostatic interference of Indian king cobra (Ophiophagus hannah) Venom. Comparison with three other snake venoms of the subcontinent.

    PubMed

    Gowtham, Yashonandana J; Kumar, M S; Girish, K S; Kemparaju, K

    2012-06-01

    Unlike Naja naja, Bungarus caeruleus, Echis carinatus, and Daboia/Vipera russellii venoms, Ophiophagus hannah venom is medically ignored in the Indian subcontinent. Being the biggest poisonous snake, O. hannah has been presumed to inject several lethal doses of venom in a single bite. Lack of therapeutic antivenom to O. hannah bite in India makes any attempt to save the victim a difficult exercise. This study was initiated to compare O. hannah venom with the above said venoms for possible interference in hemostasis. Ophiophagus hannah venom was found to actively interfere in hemostatic stages such as fibrin clot formation, platelet activation/aggregation, and fibrin clot dissolution. It decreased partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin clotting time (TCT). These activities are similar to that shown by E. carinatus and D. russellii venoms, and thus O. hannah venom was found to exert procoagulant activity through the common pathway of blood coagulation, while N. naja venom increased aPTT and TCT but not PT, and hence it was found to exert anticoagulant activity through the intrinsic pathway. Venoms of O. hannah, E. carinatus, and D. russellii lack plasminogen activation property as they do not hydrolyze azocasein, while they all show plasmin-like activity by degrading the fibrin clot. Although N. naja venom did not degrade azocasein, unlike other venoms, it showed feeble plasmin-like activity on fibrin clot. Venom of E. carinatus induced clotting of human platelet rich plasma (PRP), while the other three venoms interfered in agonist-induced platelet aggregation in PRP. Venom of O. hannah least inhibited the ADP induced platelet aggregation as compared to D. russellii and N. naja venoms. All these three venoms showed complete inhibition of epinephrine-induced aggregation at varied doses. However, O. hannah venom was unique in inhibiting thrombin induced aggregation. PMID:22817464

  14. Climate-change-related shifts in annual phenology of a temperate snake during the last 20 years

    NASA Astrophysics Data System (ADS)

    Rugiero, Lorenzo; Milana, Giuliano; Petrozzi, Fabio; Capula, Massimo; Luiselli, Luca

    2013-08-01

    Global warming is thought to be a far-reaching threat to biodiversity, and is supposed to influence several aspects of the ecology of animals. Global warming should influence especially the ectotherm vertebrates, which depend directly from the external thermal conditions for their activities and performances. Here, we analyze the changes in phenology which have occurred in the last 20 years in a marked population of vipers, Vipera aspis, and we try to relate these changes with the intervening climatic changes. We analyzed three metrics of viper's annual phenology: (i) annual onset of above-ground activity (hereby AOA); (ii) annual onset of feeding period (AOF); (iii) annual onset of the hibernation (AOH). The annual variations of these three phenological metrics were correlated to five variables of climatic data: (1) mean annual air temperature, (2) mean February air temperature, (3) mean July air temperature, (4) yearly number of rainy days, and (5) yearly number of days with rainstorm. We observed a statistically significant reduction of AOA values from >28 days between 1987 and 1997, to approximately 20 days from 1998 to 2011, with a similar statistical trend also found for AOF values. The number of days of delay in entering hibernation increased significantly since 1998. Three sets of relationships between climatic variables and metrics of viper phenology were statistically significant, i.e. the correlation (i) between annual mean temperature and AOA (negative), (ii) between annual mean temperature and AOF (negative), and (iii) between annual mean temperature and AOH (positive). The percent of field days (between 20th February and 20th March) with no viper observed also decreased significantly over the years. Our study showed that three different traits of the annual phenology of a Mediterranean snake are shifting in the 20+ years of monitoring, and that there is correlational evidence that these shifts are linked to intervening climate change.

  15. Estimating How Inflated or Obscured Effects of Climate Affect Forecasted Species Distribution

    PubMed Central

    Real, Raimundo; Romero, David; Olivero, Jesús; Estrada, Alba; Márquez, Ana L.

    2013-01-01

    Climate is one of the main drivers of species distribution. However, as different environmental factors tend to co-vary, the effect of climate cannot be taken at face value, as it may be either inflated or obscured by other correlated factors. We used the favourability models of four species (Alytes dickhilleni, Vipera latasti, Aquila fasciata and Capra pyrenaica) inhabiting Spanish mountains as case studies to evaluate the relative contribution of climate in their forecasted favourability by using variation partitioning and weighting the effect of climate in relation to non-climatic factors. By calculating the pure effect of the climatic factor, the pure effects of non-climatic factors, the shared climatic effect and the proportion of the pure effect of the climatic factor in relation to its apparent effect (ρ), we assessed the apparent effect and the pure independent effect of climate. We then projected both types of effects when modelling the future favourability for each species and combination of AOGCM-SRES (two Atmosphere-Ocean General Circulation Models: CGCM2 and ECHAM4, and two Special Reports on Emission Scenarios (SRES): A2 and B2). The results show that the apparent effect of climate can be either inflated (overrated) or obscured (underrated) by other correlated factors. These differences were species-specific; the sum of favourable areas forecasted according to the pure climatic effect differed from that forecasted according to the apparent climatic effect by about 61% on average for one of the species analyzed, and by about 20% on average for each of the other species. The pure effect of future climate on species distributions can only be estimated by combining climate with other factors. Transferring the pure climatic effect and the apparent climatic effect to the future delimits the maximum and minimum favourable areas forecasted for each species in each climate change scenario. PMID:23349726

  16. Interactions of the Neurotoxin Vipoxin in Solution Studied by Dynamic Light Scattering

    PubMed Central

    Georgieva, Dessislava Nikolova; Genov, Nicolay; Hristov, Krassimir; Dierks, Karsten; Betzel, Christian

    2004-01-01

    The neurotoxin vipoxin is the lethal component of the venom of Vipera ammodytes meridionalis. It is a heterodimer of a basic toxic His-48 phospholipase A2 (PLA2) and an acidic nontoxic Gln-48 PLA2. The shape of the neurotoxin and its separated components in solution as well as their interactions with calcium, the brain phospholipid phosphatidylcholine, and two inhibitors, elaidoylamide and vitamin E, were investigated by dynamic light scattering. Calcium binding is connected with a conformational change in vipoxin observed as a change of the hydrodynamic shape from oblate ellipsoid to a shape closer to a sphere. The Ca2+-bound form of vipoxin, which is catalytically active, is more compact and symmetric than the calcium-free heterodimer. Similar changes were observed as a result of the Ca2+-binding to the two separated subunits. In the presence of aggregated phosphatidylcholine, the neurotoxic complex dissociates to subunits. It is supposed that only the toxic component binds to the substrate, and the other subunit, which plays a chaperone function, remains in solution. The inhibition of vipoxin with the synthetic inhibitor elaidoylamide and the natural compound vitamin E changes the shape of the toxin from oblate to prolate ellipsoid. The inhibited toxin is more asymmetric in comparison to the native one. Similar, but not so pronounced, effects were observed after the inhibition of the monomeric and homodimeric forms of the toxic His-48 PLA2. Circular dichroism measurements in the presence of urea, methylurea, and ethylurea indicate a strong hydrophobic stabilization of the neurotoxin. Hydrophobic interactions stabilize not only the folded regions but also the regions of intersubunit contacts. PMID:14695289

  17. Area- and energy-efficient CORDIC accelerators in deep sub-micron CMOS technologies

    NASA Astrophysics Data System (ADS)

    Vishnoi, U.; Noll, T. G.

    2012-09-01

    The COordinate Rotate DIgital Computer (CORDIC) algorithm is a well known versatile approach and is widely applied in today's SoCs for especially but not restricted to digital communications. Dedicated CORDIC blocks can be implemented in deep sub-micron CMOS technologies at very low area and energy costs and are attractive to be used as hardware accelerators for Application Specific Instruction Processors (ASIPs). Thereby, overcoming the well known energy vs. flexibility conflict. Optimizing Global Navigation Satellite System (GNSS) receivers to reduce the hardware complexity is an important research topic at present. In such receivers CORDIC accelerators can be used for digital baseband processing (fixed-point) and in Position-Velocity-Time estimation (floating-point). A micro architecture well suited to such applications is presented. This architecture is parameterized according to the wordlengths as well as the number of iterations and can be easily extended for floating point data format. Moreover, area can be traded for throughput by partially or even fully unrolling the iterations, whereby the degree of pipelining is organized with one CORDIC iteration per cycle. From the architectural description, the macro layout can be generated fully automatically using an in-house datapath generator tool. Since the adders and shifters play an important role in optimizing the CORDIC block, they must be carefully optimized for high area and energy efficiency in the underlying technology. So, for this purpose carry-select adders and logarithmic shifters have been chosen. Device dimensioning was automatically optimized with respect to dynamic and static power, area and performance using the in-house tool. The fully sequential CORDIC block for fixed-point digital baseband processing features a wordlength of 16 bits, requires 5232 transistors, which is implemented in a 40-nm CMOS technology and occupies a silicon area of 1560 μm2 only. Maximum clock frequency from circuit

  18. Fast and Scalable Computation of the Forward and Inverse Discrete Periodic Radon Transform.

    PubMed

    Carranza, Cesar; Llamocca, Daniel; Pattichis, Marios

    2016-01-01

    The discrete periodic radon transform (DPRT) has extensively been used in applications that involve image reconstructions from projections. Beyond classic applications, the DPRT can also be used to compute fast convolutions that avoids the use of floating-point arithmetic associated with the use of the fast Fourier transform. Unfortunately, the use of the DPRT has been limited by the need to compute a large number of additions and the need for a large number of memory accesses. This paper introduces a fast and scalable approach for computing the forward and inverse DPRT that is based on the use of: a parallel array of fixed-point adder trees; circular shift registers to remove the need for accessing external memory components when selecting the input data for the adder trees; an image block-based approach to DPRT computation that can fit the proposed architecture to available resources; and fast transpositions that are computed in one or a few clock cycles that do not depend on the size of the input image. As a result, for an N × N image (N prime), the proposed approach can compute up to N(2) additions per clock cycle. Compared with the previous approaches, the scalable approach provides the fastest known implementations for different amounts of computational resources. For example, for a 251×251 image, for approximately 25% fewer flip-flops than required for a systolic implementation, we have that the scalable DPRT is computed 36 times faster. For the fastest case, we introduce optimized just 2N + ⌈log(2) N⌉ + 1 and 2N + 3 ⌈log(2) N⌉ + B + 2 cycles, architectures that can compute the DPRT and its inverse in respectively, where B is the number of bits used to represent each input pixel. On the other hand, the scalable DPRT approach requires more 1-b additions than for the systolic implementation and provides a tradeoff between speed and additional 1-b additions. All of the proposed DPRT architectures were implemented in VHSIC Hardware Description Language

  19. Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with anti-inflammatory activity.

    PubMed

    Jameel, Noor Mohamed; Shekhar, Mysore A; Vishwanath, Bannikuppe S

    2006-12-14

    Alpha-lipoic acid (ALA) and its reduced form dihydrolipoic acid (DHLA) are powerful antioxidants both in hydrophilic and lipophylic environments with diverse pharmacological properties including anti-inflammatory activity. The mechanism of anti-inflammatory activity of ALA and DHALA is not known. The present study describes the interaction of ALA and DHALA with pro-inflammatory secretory PLA(2) enzymes from inflammatory fluids and snake venoms. In vitro enzymatic inhibition of sPLA(2) from Vipera russellii, Naja naja and partially purified sPLA(2) enzymes from human ascitic fluid (HAF), human pleural fluid (HPF) and normal human serum (HS) by ALA and DHLA was studied using (14)C-oleate labeled Escherichia coli as the substrate. Biophysical interaction of ALA with sPLA(2) was studied by fluorescent spectral analysis and circular dichroism studies. In vivo anti-inflammatory activity was checked using sPLA(2) induced mouse paw edema model. ALA but not DHLA inhibited purified sPLA(2) enzymes from V. russellii, N. naja and partially purified HAF, HPF and HS in a dose dependent manner. This data indicated that ALA is critical for inhibition. IC(50) value calculated for these enzymes ranges from 0.75 to 3.0 microM. The inhibition is independent of calcium and substrate concentration. Inflammatory sPLA(2) enzymes are more sensitive to inhibition by ALA than snake venom sPLA(2) enzymes. ALA quenched the fluorescence intensity of sPLA(2) enzyme in a dose dependent manner. Apparent shift in the far UV-CD spectra of sPLA(2) with ALA indicated change in its alpha-helical confirmation and these results suggest its direct interaction with the enzyme. ALA inhibits the sPLA(2) induced mouse paw edema in a dose dependent manner and confirms the sPLA(2) inhibitory activity in vivo also. These data suggest that ALA may act as an endogenous regulator of sPLA(2) enzyme activity and suppress inflammatory reactions. PMID:17011589

  20. Digital Cartographic Models as Analysis Support in Multicriterial Assessment of Vulnerable Flood Risk Elements

    NASA Astrophysics Data System (ADS)

    Nichersu, Iulian; Mierla, Marian; Trifanov, Cristian; Nichersu, Iuliana; Marin, Eugenia; Sela, Florentina

    2014-05-01

    In the last 20 years there has been an increase of frequency in extreme weather and hydrological events. This frequency increase arise the need to research the risk to the events that are extreme and has big impact to the environment. This paper presents a method to analysis the vulnerable elements to the risk at extreme hydrological event, to be more precisely to flood. The method is using also the LiDAR point cloud. The risk concept has two main components: the first one hazard (represented by frequency of the occurrence and intensity of the flood) and the second one vulnerability (represented by the vulnerable elements to the flood). The studied area in the present paper is situated in the South-East of Europe (Romania, Danube Delta). The Digital Cartographic Models were accomplished by using the LiDAR data obtained within the CARTODD project. The digital cartographic models, with high resolution, consist of 3 components: digital terrain model (DTM), digital elevation model (DEM) and elevation classes (EC). Completing the information of the three models there were used also the orthophotos in visible (VIS) and infrared (IR) spectrum slices. Digital Terrain Model gives information on the altitude of the terrain and indirect of the flood hazard, taking into account the high resolution that the final product has. Digital Elevation Model supplies information related to the surfaces of the terrain plus the altitude of each object on the surface. This model helps to reach to the third model the Elevation Classes Model. We present here three categories of applications of clouds points analyses in floodrisk assessment: buildings assessment, endangered species mentioned in Annex 1 of the European Habitats Directive and morphologic/habitats damages. Pilot case studies of these applications are: Sulina town; endangering species like Osmoderma eremita, Vipera ursini and Spermophilus citellus; Sireasa Polder. For Sulina town was assessed the manmade vulnerable elements to

  1. A high-speed multiplexer-based fine-grain pipelined architecture for digital fuzzy logic controllers

    NASA Astrophysics Data System (ADS)

    Rashidi, Bahram; Masoud Sayedi, Sayed

    2015-12-01

    Design and implementation of a high-speed multiplexer-based fine-grain pipelined architecture for a general digital fuzzy logic controller has been presented. All the operators have been designed at gate level. For the multiplication, a multiplexer-based modified Wallace tree multiplier has been designed, and for the division and addition multiplexer-based non-restoring parallel divider and multiplexer-based Manchester adder have been used, respectively. To further increase the processing speed, fine-grain pipelining technique has been employed. By using this technique, the critical path of the circuit is broken into finer pieces. Based on the proposed architecture, and by using Quartus II 9.1, a sample two-input, one-output digital fuzzy logic controller with eight rules has been successfully synthesised and implemented on Stratix II field programmable gate array. Simulations were carried out using DSP Builder in the MATLAB/Simulink tool at a maximum clock rate of 301.84 MHz.

  2. DNA computing circuits using libraries of DNAzyme subunits

    NASA Astrophysics Data System (ADS)

    Elbaz, Johann; Lioubashevski, Oleg; Wang, Fuan; Remacle, Françoise; Levine, Raphael D.; Willner, Itamar

    2010-06-01

    Biological systems that are capable of performing computational operations could be of use in bioengineering and nanomedicine, and DNA and other biomolecules have already been used as active components in biocomputational circuits. There have also been demonstrations of DNA/RNA-enzyme-based automatons, logic control of gene expression, and RNA systems for processing of intracellular information. However, for biocomputational circuits to be useful for applications it will be necessary to develop a library of computing elements, to demonstrate the modular coupling of these elements, and to demonstrate that this approach is scalable. Here, we report the construction of a DNA-based computational platform that uses a library of catalytic nucleic acids (DNAzymes), and their substrates, for the input-guided dynamic assembly of a universal set of logic gates and a half-adder/half-subtractor system. We demonstrate multilayered gate cascades, fan-out gates and parallel logic gate operations. In response to input markers, the system can regulate the controlled expression of anti-sense molecules, or aptamers, that act as inhibitors for enzymes.

  3. Design of easily testable systems

    SciTech Connect

    Rawat, S.S.

    1988-01-01

    This thesis presents structured testability techniques that can be applied to systolic arrays. Systolic arrays for signal processing have produced processing rates far in excess of general-purpose architecture. Fast testing is considered as one of the design criteria. The main goal is to derive test vectors for one- and two-dimensional systolic arrays. The author seeks to keep the number of test vectors independent of the size of the array under a generic fault model. The testable design is based on pseudo-exhaustive testing. Conventional testing uses Level Sensitive Scan Detection (LSSD) techniques which are very time consuming for an array of systolic processors. By making the testability analysis early the logic designer will be able to make early (and repeated) design trade-offs that make design for testability a simple extension of the design process. The author shows how one-dimensional sequential systolic arrays can be designed so that the faults can be easily detected and isolated. He also considers unilateral two-dimensional sequential arrays and suggests modifications to make them easily testable. Finally, he shows how a modified carry look ahead adder of arbitrary size can be tested with just 136 test vectors. Comparisons are made against the standard LSSD technique.

  4. Techniques for design and testing of iterative and systolic arrays. [C-testability concept

    SciTech Connect

    Elhuni, H.A.

    1986-01-01

    In this thesis, the author studies the issue of testing array-type structures such as iterative arrays of combinational cells and systolic arrays with a constant number of test vectors independent of the array size (C-Testability). The main contribution of this work is the extension of the C-testability concept in different directions. It is extended to orthogonally connected iterative arrays in chapter three. This is a contribution to the C-testability theory because of the undecidability property of general two-dimensional arrays. The C-testability is extended further to hexagonal iterative arrays in chapter four. The application of the C-testability concept was limited to few arrays such as ripple-carry adders, bit-sliced microprocessors and array multipliers. In chapter five, the author extended the concept to systolic arrays and apply it to some systolic designs. The application to hexagonal systolic arrays is made in chapter six. It is shown that several systolic arrays such as those used for matrix multiplication can be tested with a small number of test vectors; twice the number required to test a single cell. The testing time of such arrays is also introduced and discussed. In chapter seven, he introduces a new concept called STV-testability for testing bilateral systolic arrays. STV-testable arrays have simple test generation and verification procedures.

  5. A Single Chip VLSI Implementation of a QPSK/SQPSK Demodulator for a VSAT Receiver Station

    NASA Technical Reports Server (NTRS)

    Kwatra, S. C.; King, Brent

    1995-01-01

    This thesis presents a VLSI implementation of a QPSK/SQPSK demodulator. It is designed to be employed in a VSAT earth station that utilizes the FDMA/TDM link. A single chip architecture is used to enable this chip to be easily employed in the VSAT system. This demodulator contains lowpass filters, integrate and dump units, unique word detectors, a timing recovery unit, a phase recovery unit and a down conversion unit. The design stages start with a functional representation of the system by using the C programming language. Then it progresses into a register based representation using the VHDL language. The layout components are designed based on these VHDL models and simulated. Component generators are developed for the adder, multiplier, read-only memory and serial access memory in order to shorten the design time. These sub-components are then block routed to form the main components of the system. The main components are block routed to form the final demodulator.

  6. Thermal management in high average power pulsed compression systems

    SciTech Connect

    Wavrik, R.W.; Reed, K.W.; Harjes, H.C.; Weber, G.J.; Butler, M.; Penn, K.J.; Neau, E.L.

    1992-08-01

    High average power repetitively pulsed compression systems offer a potential source of electron beams which may be applied to sterilization of wastes, treatment of food products, and other environmental and consumer applications. At Sandia National Laboratory, the Repetitive High Energy Pulsed Power (RHEPP) program is developing a 7 stage magnetic pulse compressor driving a linear induction voltage adder with an electron beam diode load. The RHEPP machine is being design to deliver 350 kW of average power to the diode in 60 ns FWHM, 2.5 MV, 3 kJ pulses at a repetition rate of 120 Hz. In addition to the electrical design considerations, the repetition rate requires thermal management of the electrical losses. Steady state temperatures must be kept below the material degradation temperatures to maximize reliability and component life. The optimum design is a trade off between thermal management, maximizing overall electrical performance of the system, reliability, and cost effectiveness. Cooling requirements and configurations were developed for each of the subsystems of RHEPP. Finite element models that combine fluid flow and heat transfer were used to screen design concepts. The analysis includes one, two, and three dimensional heat transfer using surface heat transfer coefficients and boundary layer models. Experiments were conducted to verify the models as well as to evaluate cooling channel fabrication materials and techniques in Metglas wound cores. 10 refs.

  7. Thermal management in high average power pulsed compression systems

    SciTech Connect

    Wavrik, R.W.; Reed, K.W.; Harjes, H.C.; Weber, G.J.; Butler, M.; Penn, K.J.; Neau, E.L.

    1992-01-01

    High average power repetitively pulsed compression systems offer a potential source of electron beams which may be applied to sterilization of wastes, treatment of food products, and other environmental and consumer applications. At Sandia National Laboratory, the Repetitive High Energy Pulsed Power (RHEPP) program is developing a 7 stage magnetic pulse compressor driving a linear induction voltage adder with an electron beam diode load. The RHEPP machine is being design to deliver 350 kW of average power to the diode in 60 ns FWHM, 2.5 MV, 3 kJ pulses at a repetition rate of 120 Hz. In addition to the electrical design considerations, the repetition rate requires thermal management of the electrical losses. Steady state temperatures must be kept below the material degradation temperatures to maximize reliability and component life. The optimum design is a trade off between thermal management, maximizing overall electrical performance of the system, reliability, and cost effectiveness. Cooling requirements and configurations were developed for each of the subsystems of RHEPP. Finite element models that combine fluid flow and heat transfer were used to screen design concepts. The analysis includes one, two, and three dimensional heat transfer using surface heat transfer coefficients and boundary layer models. Experiments were conducted to verify the models as well as to evaluate cooling channel fabrication materials and techniques in Metglas wound cores. 10 refs.

  8. Modeling and optimization of ultra high speed devices and circuits

    SciTech Connect

    Jandaghi-Semnani, M.

    1989-01-01

    This thesis consists of two parts. In part one, we have developed an optimization scheme for designing submicron metal-oxide-semiconductor field effect transistors (MOSFETs). The scheme, which is based on the concepts of a mathematical programming problem, considers all the necessary performance and reliability issues and attempts to approach a desired set of target values. The modified pattern search method is used to implement the optimization scheme selected in this work. Simulated results have been compared with experimental data, and excellent agreement has been observed. Using the optimization scheme, a 0.6 {mu}m channel length MOSFET for possible dynamic random access memory (DRAM) applications has been designed. The other part of this thesis is devoted to the design of an ultra-fast 8 x 8-bit multiplier/accumulator circuit based on a resonant tunneling transistor (RTT) technology. The multiplier circuit has a parallel architecture and uses the carry save adder technique. The design of all the logic gates of the multiplier/accumulator circuit is based on the three logics: NAND, NOR, and NOT. The number of transistors applied in the RTT circuit is 2371, and the active chip area is about 0.30mm{sup 2}. The multiplier speed is 79 ps with an average power dissipation of 2.28 miliwatts (mW). The clock signals required for the operation of the chip are generated by a clock driver circuit which was designed by a ring oscillator and a binary counter circuit.

  9. Fully synthesised decimation filter for delta-sigma A/D converters

    NASA Astrophysics Data System (ADS)

    Roh, Hyungdong; Byun, Sanho; Choi, Youngkil; Roh, Jeongjin

    2010-06-01

    Digital decimation filters are used in delta-sigma analogue-to-digital converters to reduce the oversampled data rate to the final Nyquist rate. This paper presents the design and implementation of a fully synthesised digital decimation filter that provides a time-to-market advantage. The filter consists of a cascaded integrator-comb filter and two cascaded half-band FIR filters. A canonical signed-digit representation of the filter coefficients is used to minimise the area and to reduce the hardware complexity of the multiplication arithmetic. Coefficient multiplications are implemented by using shifters and adders. This three-stage decimation filter is fabricated by using 0.25-μm CMOS technology with an active area of 1.36 mm2 and shows 4.4 mW power consumption at a clock rate of 2.8224 MHz. Experimental results show that this digital decimation filter is suitable for use in oversampled data converters and can be applied to new processes requiring a fast redesign time. This is possible because the filter does not have process-dependent ROM or RAM circuits.

  10. A 15-bit incremental sigma-delta ADC for CMOS image sensor

    NASA Astrophysics Data System (ADS)

    Chen, Nan; Li, Zhengfen; Zhong, Shengyou; Zou, Mei; Yao, Libin

    2015-04-01

    An incremental sigma-delta ADC is designed for column-parallel ADC array in CMOS image sensor. Sigma-delta modulator with single-loop single-bit structure is chosen for power consumption and performance reasons. Second-order modulator is used to reduce conversion time, without stability problem and large area accompanied by higher order sigma-delta modulator. The asymmetric current mirror amplifier used in integrator reduces more than 30% power dissipation. The digital filter and decimator are implemented by counters and adders with significantly reduced chip area and power consumption. A Clock generator is shared by 8 ADCs for trade-off among power, area and clock loading. The ADC array is implemented in a 0.18-μm CMOS technology and clocked at 10 MHz, and the simulated resolution achieves 15-bit with 255 clock cycles. The average power consumption per ADC is 118 μW including clock generator, and the area is only 0.0053 μm2.

  11. Boolean gates on actin filaments

    NASA Astrophysics Data System (ADS)

    Siccardi, Stefano; Tuszynski, Jack A.; Adamatzky, Andrew

    2016-01-01

    Actin is a globular protein which forms long polar filaments in the eukaryotic cytoskeleton. Actin networks play a key role in cell mechanics and cell motility. They have also been implicated in information transmission and processing, memory and learning in neuronal cells. The actin filaments have been shown to support propagation of voltage pulses. Here we apply a coupled nonlinear transmission line model of actin filaments to study interactions between voltage pulses. To represent digital information we assign a logical TRUTH value to the presence of a voltage pulse in a given location of the actin filament, and FALSE to the pulse's absence, so that information flows along the filament with pulse transmission. When two pulses, representing Boolean values of input variables, interact, then they can facilitate or inhibit further propagation of each other. We explore this phenomenon to construct Boolean logical gates and a one-bit half-adder with interacting voltage pulses. We discuss implications of these findings on cellular process and technological applications.

  12. Capacitor blocks for linear transformer driver stages.

    PubMed

    Kovalchuk, B M; Kharlov, A V; Kumpyak, E V; Smorudov, G V; Zherlitsyn, A A

    2014-01-01

    In the Linear Transformer Driver (LTD) technology, the low inductance energy storage components and switches are directly incorporated into the individual cavities (named stages) to generate a fast output voltage pulse, which is added along a vacuum coaxial line like in an inductive voltage adder. LTD stages with air insulation were recently developed, where air is used both as insulation in a primary side of the stages and as working gas in the LTD spark gap switches. A custom designed unit, referred to as a capacitor block, was developed for use as a main structural element of the transformer stages. The capacitor block incorporates two capacitors GA 35426 (40 nF, 100 kV) and multichannel multigap gas switch. Several modifications of the capacitor blocks were developed and tested on the life time and self breakdown probability. Blocks were tested both as separate units and in an assembly of capacitive module, consisting of five capacitor blocks. This paper presents detailed design of capacitor blocks, description of operation regimes, numerical simulation of electric field in the switches, and test results. PMID:24517759

  13. Study on AC-DC Electrical Conductivities in Warm Dense Matter Generated by Pulsed-power Discharge with Isochoric Vessel

    NASA Astrophysics Data System (ADS)

    Sasaki, Toru; Ohuchi, Takumi; Takahashi, Takuya; Kawaguchi, Yoshinari; Saito, Hirotaka; Miki, Yasutoshi; Takahashi, Kazumasa; Kikuchi, Takashi; Aso, Tsukasa; Harada, Nob.

    2016-03-01

    To observe AC and DC electrical conductivity in warm dense matter (WDM), we have demonstrated to apply the spectroscopic ellipsometry for a pulsed-power discharge with isochoric vessel. At 10 μs from the beginning of discharge, the generated parameters by using pulsed-power discharge with isochoric vessel are 0.1 ρ s (ρ s: solid density) of density and 4000 K of temperature, respectively. The DC electrical conductivity for above parameters is estimated to be 104 S/m. In order to measure the AC electrical conductivity, we have developed a four-detector spectroscopic ellipsometer with a multichannel spectrometer. The multichannel spectrometer, in which consists of a 16-channel photodiode array, a two-stages voltage adder, and a flat diffraction grating, has 10 MHz of the frequency response with covered visible spectrum. For applying the four-detector spectroscopic ellipsometer, we observe the each observation signal evolves the polarized behavior compared to the ratio as I 1/I 2.

  14. External cavity based single mode Fabry-Pérot laser diode and its application towards all-optical digital circuits

    NASA Astrophysics Data System (ADS)

    Nakarmi, Bikash; Zhang, Xuping; Won, Yong Hyub

    2012-11-01

    We have proposed a novel approach of realizing all-optical logic gates and combinational circuit using external cavity based single mode Fabry-Pérot laser diodes (SMFP-LDs). Different techniques and critical parameters for injection locking the any one of the modes of SMFP-LDs are discussed. Taking consideration of wavelength detuning and input injected power, we have proposed and demonstrated multi-input injection locking, supporting beam injection locking with the conventional injection locking which are used for demonstrating different logic gates (NAND, AND, XNOR, XOR, NOT, NOR) and digital circuits (Half adder and Comparator). Since we have used SMFP-LDs, there is no requirement of additional probe beam and associated components as required by other optical technologies making the realization simple in configuration, cost effective and power efficient. Clear output waveforms, eye diagrams, risingfalling times and BER are presented to verify the proposed method. All-optical logic units and digital circuit are demonstrated at the data rate of 10 Gbps with the waveform of NRZ signal waveform and measured eye diagram and BER of the PRBS of 231-1 signal. The maximum power penalty among all demonstrated units is below 1.4 dB at the BER of 10-9.

  15. Evaluation of a gamma camera system for the RITS-6 accelerator using the self-magnetic pinch diode

    NASA Astrophysics Data System (ADS)

    Webb, Timothy J.; Kiefer, Mark L.; Gignac, Raymond; Baker, Stuart A.

    2015-08-01

    The self-magnetic pinch (SMP) diode is an intense radiographic source fielded on the Radiographic Integrated Test Stand (RITS-6) accelerator at Sandia National Laboratories in Albuquerque, NM. The accelerator is an inductive voltage adder (IVA) that can operate from 2-10 MV with currents up to 160 kA (at 7 MV). The SMP diode consists of an annular cathode separated from a flat anode, holding the bremsstrahlung conversion target, by a vacuum gap. Until recently the primary imaging diagnostic utilized image plates (storage phosphors) which has generally low DQE at these photon energies along with other problems. The benefits of using image plates include a high-dynamic range, good spatial resolution, and ease of use. A scintillator-based X-ray imaging system or "gamma camera" has been fielded in front of RITS and the SMP diode which has been able to provide vastly superior images in terms of signal-to-noise with similar resolution and acceptable dynamic range.

  16. Plasmonic-multimode-interference-based logic circuit with simple phase adjustment

    PubMed Central

    Ota, Masashi; Sumimura, Asahi; Fukuhara, Masashi; Ishii, Yuya; Fukuda, Mitsuo

    2016-01-01

    All-optical logic circuits using surface plasmon polaritons have a potential for high-speed information processing with high-density integration beyond the diffraction limit of propagating light. However, a number of logic gates that can be cascaded is limited by complicated signal phase adjustment. In this study, we demonstrate a half-adder operation with simple phase adjustment using plasmonic multimode interference (MMI) devices, composed of dielectric stripes on a metal film, which can be fabricated by a complementary metal-oxide semiconductor (MOS)-compatible process. Also, simultaneous operations of XOR and AND gates are substantiated experimentally by combining 1 × 1 MMI based phase adjusters and 2 × 2 MMI based intensity modulators. An experimental on-off ratio of at least 4.3 dB is confirmed using scanning near-field optical microscopy. The proposed structure will contribute to high-density plasmonic circuits, fabricated by complementary MOS-compatible process or printing techniques. PMID:27086694

  17. Recent development work on PIM : a Blumlein driven IVA machine.

    SciTech Connect

    Phillips, Martin J.; Sinclair, Mark A.; Williamson, Mark C.; Clough, Stephen G.; Thomas, Kenneth J.; Smith, Ian Douglas; Bailey, Vernon Leslie; Johnson, David Lee; Corcoran, Patrick Allen; Kishi, Hiroshi J.; Maenchen, John Eric

    2003-08-01

    An IVA (inductive voltage adder) research programme at AWE began with the construction of a small scale IVA test bed named LINX and progressed to building PIM (Prototype IVA Module). The work on PIM is geared towards furnishing AWE with a range of machines operating at 1 to 4 MV that may eventually supersede, with an upgrade in performance, existing machines operating in that voltage range. PIM has a water dielectric Blumlein of 10 ohms charged by a Marx generator. This has been used to drive either one or two 1.5 MV inductive cavities and fitting a third cavity may be attempted in the future. The latest two cavity configuration is shown which requires a split oil coax to connect the two cavities in parallel. It also has a laser triggering system for initiating the Blumlein and the prepulse reduction system fitted to the output of the Blumlein. A short MITL (magnetically insulated transmission line) connects the cavities, via a vacuum pumping section, to a chamber containing an e-beam diode test load.

  18. Healing with animals in the Levant from the 10th to the 18th century

    PubMed Central

    Lev, Efraim

    2006-01-01

    Animals and products derived from different organs of their bodies have constituted part of the inventory of medicinal substances used in various cultures since ancient times. The article reviews the history of healing with animals in the Levant (The Land of Israel and parts of present-day Syria, Lebanon, and Jordan, defined by the Muslims in the Middle Ages as Bilad al-Sham) in the medieval and early Ottoman periods. Intensive research into the phenomenon of zootherapy in the medieval and early Ottoman Levant has yielded forty-eight substances of animal origin that were used medicinally. The vast majority of these substances were local and relatively easy to obtain. Most of the substances were domestic (honey, wax, silkworm, etc.), others were part of the local wildlife (adder, cuttle fish, flycatcher, firefly, frog, triton, scorpion, etc.), part of the usual medieval household (milk, egg, cheese, lamb, etc.), or parasites (louse, mouse, stinkbug, etc.). Fewer substances were not local but exotic, and therefore rare and expensive (beaver testicles, musk oil, coral, ambergris, etc.). The range of symptoms that the substances of animal origin were used to treat was extensive and included most of the known diseases and maladies of that era: mainly hemorrhoids, burns, impotence, wounds, and skin, eye, and stomach diseases. Changes in the moral outlook of modern societies caused the use of several substances of animal origin to cease in the course of history. These include mummy, silkworm, stinkbug, scarabees, snail, scorpion, and triton. PMID:16504024

  19. Plasmonic-multimode-interference-based logic circuit with simple phase adjustment.

    PubMed

    Ota, Masashi; Sumimura, Asahi; Fukuhara, Masashi; Ishii, Yuya; Fukuda, Mitsuo

    2016-01-01

    All-optical logic circuits using surface plasmon polaritons have a potential for high-speed information processing with high-density integration beyond the diffraction limit of propagating light. However, a number of logic gates that can be cascaded is limited by complicated signal phase adjustment. In this study, we demonstrate a half-adder operation with simple phase adjustment using plasmonic multimode interference (MMI) devices, composed of dielectric stripes on a metal film, which can be fabricated by a complementary metal-oxide semiconductor (MOS)-compatible process. Also, simultaneous operations of XOR and AND gates are substantiated experimentally by combining 1 × 1 MMI based phase adjusters and 2 × 2 MMI based intensity modulators. An experimental on-off ratio of at least 4.3 dB is confirmed using scanning near-field optical microscopy. The proposed structure will contribute to high-density plasmonic circuits, fabricated by complementary MOS-compatible process or printing techniques. PMID:27086694

  20. High precision computing with charge domain devices and a pseudo-spectral method therefor

    NASA Technical Reports Server (NTRS)

    Barhen, Jacob (Inventor); Toomarian, Nikzad (Inventor); Fijany, Amir (Inventor); Zak, Michail (Inventor)

    1997-01-01

    The present invention enhances the bit resolution of a CCD/CID MVM processor by storing each bit of each matrix element as a separate CCD charge packet. The bits of each input vector are separately multiplied by each bit of each matrix element in massive parallelism and the resulting products are combined appropriately to synthesize the correct product. In another aspect of the invention, such arrays are employed in a pseudo-spectral method of the invention, in which partial differential equations are solved by expressing each derivative analytically as matrices, and the state function is updated at each computation cycle by multiplying it by the matrices. The matrices are treated as synaptic arrays of a neural network and the state function vector elements are treated as neurons. In a further aspect of the invention, moving target detection is performed by driving the soliton equation with a vector of detector outputs. The neural architecture consists of two synaptic arrays corresponding to the two differential terms of the soliton-equation and an adder connected to the output thereof and to the output of the detector array to drive the soliton equation.

  1. Fast parallel molecular algorithms for DNA-based computation: solving the elliptic curve discrete logarithm problem over GF2.

    PubMed

    Li, Kenli; Zou, Shuting; Xv, Jin

    2008-01-01

    Elliptic curve cryptographic algorithms convert input data to unrecognizable encryption and the unrecognizable data back again into its original decrypted form. The security of this form of encryption hinges on the enormous difficulty that is required to solve the elliptic curve discrete logarithm problem (ECDLP), especially over GF(2(n)), n in Z+. This paper describes an effective method to find solutions to the ECDLP by means of a molecular computer. We propose that this research accomplishment would represent a breakthrough for applied biological computation and this paper demonstrates that in principle this is possible. Three DNA-based algorithms: a parallel adder, a parallel multiplier, and a parallel inverse over GF(2(n)) are described. The biological operation time of all of these algorithms is polynomial with respect to n. Considering this analysis, cryptography using a public key might be less secure. In this respect, a principal contribution of this paper is to provide enhanced evidence of the potential of molecular computing to tackle such ambitious computations. PMID:18431451

  2. Field programmable gate arrays implementation of Dual Tree Complex Wavelet Transform.

    PubMed

    Canbay, Ferhat; Levent, Vecdi Emre; Serbes, Gorkem; Goren, Sezer; Aydin, Nizamettin

    2015-08-01

    Due to the inherent time-varying characteristics of physiological systems, most biomedical signals (BSs) are expected to have non-stationary character. Therefore, any appropriate analysis method for dealing with BSs should exhibit adjustable time-frequency (TF) resolution. The wavelet transform (WT) provides a TF representation of signals, which has good frequency resolution at low frequencies and good time resolution at high frequencies, resulting in an optimized TF resolution. Discrete wavelet transform (DWT), which is used in various medical signal processing applications such as denoising and feature extraction, is a fast and discretized algorithm for classical WT. However, the DWT has some very important drawbacks such as aliasing, lack of directionality, and shift-variance. To overcome these drawbacks, a new improved discrete transform named as Dual Tree Complex Wavelet Transform (DTCWT) can be used. Nowadays, with the improvements in embedded system technology, portable real-time medical devices are frequently used for rapid diagnosis in patients. In this study, in order to implement DTCWT algorithm in FPGAs, which can be used as real-time feature extraction or denoising operator for biomedical signals, a novel hardware architecture is proposed. In proposed architecture, DTCWT is implemented with only one adder and one multiplier. Additionally, considering the multi-channel outputs of biomedical data acquisition systems, this architecture is capable of running N channels in parallel. PMID:26737665

  3. In-Situ Anode Heating and Its Effects on Atomic Constituents in the A-K Gap in Self-Magnetic Pinch (SMP) Experiments

    NASA Astrophysics Data System (ADS)

    Simpson, Sean; Renk, Timothy; Johnston, Mark; Mazarakis, Mike; Patel, Sonal

    2015-11-01

    The RITS-6 inductive voltage adder (IVA) accelerator (3.5-8.5 MeV) at Sandia National Laboratories produces high-power (TW) focused electron beams (<3mm diameter) for flash x-ray radiography applications. The Self-Magnetic Pinch (SMP) diode utilizes a hollowed metal cathode to produce a pinched focus onto a high-Z metal anode converter. There is not a clear understanding as to the effects various contaminants such as C, CO, H, H2O, HmCn, O2, and N2, on the anode surface or in the bulk may have on impedance dynamics, beam stability, beam spot size, and reproducibility. Heating pure Ta anodes with and without a thin Al coating have been investigated using temperatures ranging from 400 °C to 1000 °C. Initial experiments indicate a significant reduction in H and C as seen in high-speed spectral analysis of plasmas at the converter and a reduction in the back-streaming proton current. Experiments are ongoing, and latest results will be reported. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  4. Low-complexity feed-forward carrier phase estimation for M-ary QAM based on phase search acceleration by quadratic approximation.

    PubMed

    Xiang, Meng; Fu, Songnian; Deng, Lei; Tang, Ming; Shum, Perry; Liu, Deming

    2015-07-27

    Blind phase search (BPS) algorithm for M-QAM has excellent tolerance to laser linewidth at the expense of rather high computation complexity (CC). Here, we first theoretically obtain the quadratic relationship between the test angle and corresponding distance matric during the BPS implementation. Afterwards, we propose a carrier phase estimation (CPE) based on a two-stage BPS with quadratic approximation (QA). Instead of searching the phase blindly with fixed step-size for the BPS algorithm, QA can significantly accelerate the speed of phase searching. As a result, a group factor of 2.96/3.05, 4.55/4.67 and 2.27/2.3 (in the form of multipliers/adders) reduction of CC is achieved for 16QAM, 64QAM and 256QAM, respectively, in comparison with the traditional BPS scheme. Meanwhile, a guideline for determining the summing filter block length is put forward during performance optimization. Under the condition of optimum filter block length, our proposed scheme shows similar performance as traditional BPS scheme. At 1 dB required E(S)/N(0) penalty @ BER = 10(-2), our proposed CPE scheme can tolerate a times symbol duration productΔf⋅T(S) of 1.7 × 10(-4), 6 × 10(-5) and 1.5 × 10(-5) for 16/64/256-QAM, respectively. PMID:26367577

  5. Chip-integrated ultrawide-band all-optical logic comparator in plasmonic circuits

    PubMed Central

    Lu, Cuicui; Hu, Xiaoyong; Yang, Hong; Gong, Qihuang

    2014-01-01

    Optical computing opens up the possibility for the realization of ultrahigh-speed and ultrawide-band information processing. Integrated all-optical logic comparator is one of the indispensable core components of optical computing systems. Unfortunately, up to now, no any nanoscale all-optical logic comparator suitable for on-chip integration applications has been realized experimentally. Here, we report a subtle and effective technical solution to circumvent the obstacles of inherent Ohmic losses of metal and limited propagation length of SPPs. A nanoscale all-optical logic comparator suitable for on-chip integration applications is realized in plasmonic circuits directly. The incident single-bit (or dual-bit) logic signals can be compared and the comparison results are endowed with different logic encodings. An ultrabroad operating wavelength range from 700 to 1000 nm, and an ultrahigh output logic-state contrast-ratio of more than 25 dB are realized experimentally. No high power requirement is needed. Though nanoscale SPP light source and the logic comparator device are integrated into the same plasmonic chip, an ultrasmall feature size is maintained. This work not only paves a way for the realization of complex logic device such as adders and multiplier, but also opens up the possibility for realizing quantum solid chips based on plasmonic circuits. PMID:24463956

  6. FPGA-based artificial neural network using CORDIC modules

    NASA Astrophysics Data System (ADS)

    Liddicoat, Albert A.; Slivovsky, Lynne A.; McLenegan, Tim; Heyer, Don

    2006-08-01

    Artificial neural networks have been used in applications that require complex procedural algorithms and in systems which lack an analytical mathematic model. By designing a large network of computing nodes based on the artificial neuron model, new solutions can be developed for computational problems in fields such as image processing and speech recognition. Neural networks are inherently parallel since each neuron, or node, acts as an autonomous computational element. Artificial neural networks use a mathematical model for each node that processes information from other nodes in the same region. The information processing entails computing a weighted average computation followed by a nonlinear mathematical transformation. Some typical artificial neural network applications use the exponential function or trigonometric functions for the nonlinear transformation. Various simple artificial neural networks have been implemented using a processor to compute the output for each node sequentially. This approach uses sequential processing and does not take advantage of the parallelism of a complex artificial neural network. In this work a hardware-based approach is investigated for artificial neural network applications. A Field Programmable Gate Arrays (FPGAs) is used to implement an artificial neuron using hardware multipliers, adders and CORDIC functional units. In order to create a large scale artificial neural network, area efficient hardware units such as CORDIC units are needed. High performance and low cost bit serial CORDIC implementations are presented. Finally, the FPGA resources and the performance of a hardware-based artificial neuron are presented.

  7. Area, time, power optimization for radix-2 redundant CORDIC rotation engines

    NASA Astrophysics Data System (ADS)

    Srikanthan, Thambipillai; Gisuthan, Bimal; Asari, K. V.

    1999-10-01

    CORDIC rotation engines have become with primary hardware- computing modules for realization of trigonometric functions in real time digital signal processing. We propose an area- time efficient architecture for redundant CORDIC with significant power savings. The precomputation of signed digits for rotation mode leads to a reduced transition density in the Z-recurrences. This leads to a reduced switching activity that results in lower power dissipation. The parallelized generation of the signed digits in the CORDIC rotation engine results in over 30 percent savings in hardware with significant speed up of operation. As no estimates are used for the precomputation of the singed digits no correcting rotations are necessary. The number of iteration that needs to be repeated is one irrespective of the accuracy of operation needed and the scaling factor is constant. The computation of the signed digits is removed from the critical path of the design and the response time of the circuit is dependent only on the full adder delay in the CMOS technology library used for implementation. The designs for 16-bit, 24-bit and 32-bit redundant CORDIC architectures incorporating the precomputation of signed digits are presented. The architecture for precomputation of the signed digits is simulated using SYNOPSIS VSS. The functionality simulated design is synthesized with SYNOPSIS design analyzer. The switching power is estimated using SYNOPSIS DesignPower. The proposed architecture is compared with relevant designs in literature.

  8. The Matrix Exponential Approach To Elementary Operations

    NASA Astrophysics Data System (ADS)

    Delosme, Jean-Marc

    1986-04-01

    In 1971, J.S. Walther generalized and unified J.E. Volder's coordinate rotation (CORDIC) algorithms. Using Walther's algorithms a few commonly used functions such as divide, multiply-and-accumulate, arctan, plane rotation, arctanh, hyperbolic rotation can be implemented on the same simple hardware (shifters and adders, elementary controller) and computed in approximately the same time. Can other useful functions be computed on the same hardware by further generalizing these algorithms? Our positive answer lies in a deeper understanding of Walther's unification: the key to the CORDIC algorithms is that all of them effect the multiplication of a vector by the exponential of a 2 X 2 matrix. The importance of this observation is readily demonstrated as it easily yields the convergence conditions for the CORDIC algorithms and an efficient way of extending the domain of convergence for the hyperbolic functions. A correspondence may be established between elementary functions such as square-root, √(x2+y) , inverse square-root or cubic root and exponentials of simple matrices. Whenever such a correspondence is found, a CORDIC-like algorithm for computing the function can be synthesized in a very straightforward manner. The algorithms thus derived have a simple structure and exhibit uniform convergence inside an adjustable, precisely defined, domain.

  9. Interaction of toxic venoms with the complement system

    PubMed Central

    Birdsey, Vanessa; Lindorfer, Jean; Gewurz, H.

    1971-01-01

    Thirty-nine venoms from various vertebrate and invertebrate species were tested for their ability to consume haemolytic complement (C) activity upon incubation in fresh guinea-pig serum. Nineteen had `anti-complementary' activity, and these were provisionally sorted into the following groups: Pattern I—exemplified by the Naja haje (Egyptian cobra) and six other Elapidae species (all cobras), which induced selective consumption of C3—C9, and led to formation of a stable C3—C9-consuming intermediate; Pattern II—exemplified by the Agkistrodon rhodostoma (Malayan pit viper), Bitis arietans (puff adder), Bothrops jararaca (South American pit viper), Bothrops atrox (Fer de Lance) and three other species, which induced marked consumption of C4 and C2, as well as C3—C9, but did not form a stable C3—C9-consuming intermediate; and individual animals, e.g. the Lachesis muta (bushmaster), which induced other patterns (III—VI) of complement component consumption. Active fractions of representative venoms were partially purified by ion exchange and gel filtration chromatography and their interactions with the complement system characterized further. It is anticipated that these enzymes, with a capacity to activate the complement system in unique ways, will prove to be of further experimental usefulness. PMID:4398349

  10. Synchronous universal droplet logic and control

    NASA Astrophysics Data System (ADS)

    Katsikis, Georgios; Cybulski, James S.; Prakash, Manu

    2015-07-01

    Droplets are versatile digital materials; they can be produced at high throughput, perform chemical reactions as miniature beakers and carry biological entities. Droplets have been manipulated with electric, optical, acoustic and magnetic forces, but all these methods use serial controls to address individual droplets. An alternative is algorithmic manipulation based on logic operations that automatically compute where droplets are stored or directed, thereby enabling parallel control. However, logic previously implemented in low-Reynolds-number droplet hydrodynamics is asynchronous and thus prone to errors that prevent scaling up the complexity of logic operations. Here we present a platform for error-free physical computation via synchronous universal logic. Our platform uses a rotating magnetic field that enables parallel manipulation of arbitrary numbers of ferrofluid droplets on permalloy tracks. Through the coupling of magnetic and hydrodynamic interaction forces between droplets, we developed AND, OR, XOR, NOT and NAND logic gates, fanouts, a full adder, a flip-flop and a finite-state machine. Our platform enables large-scale integration of droplet logic, analogous to the scaling seen in digital electronics, and opens new avenues in mesoscale material processing.

  11. Defectivity and particle reduction for mask life extension, and imprint mask replication for high-volume semiconductor manufacturing

    NASA Astrophysics Data System (ADS)

    Emoto, Keiji; Sakai, Fumio; Sato, Chiaki; Takabayashi, Yukio; Nakano, Hitoshi; Takabayashi, Tsuneo; Yamamoto, Kiyohito; Hattori, Tadashi; Hiura, Mitsuru; Ando, Toshiaki; Kawanobe, Yoshio; Azuma, Hisanobu; Iwanaga, Takehiko; Choi, Jin; Aghili, Ali; Jones, Chris; Irving, J. W.; Fletcher, Brian; Ye, Zhengmao

    2016-03-01

    Imprint lithography has been shown to be an effective technique for replication of nano-scale features. Jet and Flash* Imprint Lithography (J-FIL*) involves the field-by-field deposition and exposure of a low viscosity resist deposited by jetting technology onto the substrate. The patterned mask is lowered into the fluid which then quickly flows into the relief patterns in the mask by capillary action. Following this filling step, the resist is crosslinked under UV radiation, and then the mask is removed, leaving a patterned resist on the substrate. Criteria specific to any lithographic process for the semiconductor industry include overlay, throughput and defectivity. The purpose of this paper is to describe the technology advancements made in the reduction of particle adders in an imprint tool and introduce the new mask replication tool that will enable the fabrication of replica masks with added residual image placement errors suitable for memory devices with half pitches smaller than 15nm. Hard particles on a wafer or mask create the possibility of creating a permanent defect on the mask that can impact device yield and mask life. By using material methods to reduce particle shedding and by introducing an air curtain system, test stand results demonstrate the potential for extending mask life to better than 1000 wafers. Additionally, a new replication tool, the FPA-1100 NR2 is introduced. Mask chuck flatness simulation results were also performed and demonstrate that residual image placement errors can be reduced to as little as 1nm.

  12. Nanoimprint system development and status for high-volume semiconductor manufacturing

    NASA Astrophysics Data System (ADS)

    Iwamoto, Kazunori; Iwanaga, Takehiko; Sreenivasan, S. V.; Iwasa, Junji

    2015-10-01

    Imprint lithography has been shown to be an effective technique for replication of nano-scale features. Jet and Flash Imprint Lithography* (J-FIL*) involves the field-by-field deposition and exposure of a low viscosity resist deposited by jetting technology onto the substrate. The patterned mask is lowered into the fluid which then quickly flows into the relief patterns in the mask by capillary action. Following this filling step, the resist is crosslinked under UV radiation, and then the mask is removed, leaving a patterned resist on the substrate. The purpose of this paper is to describe the technology advancements made to both wafer imprint and mask replication systems that will be applied for the fabrication of advanced devices such as NAND Flash memory and DRAM. Overlay of better than 5nm (mean + 3sigma) has been demonstrated, and throughputs of better than 10 wafers per imprint station are now routinely achieved. Defectivity has been reduced by more than two orders of magnitude and particle adders within the tool have come down by approximately four orders of magnitude. A pilot line tool, the FPA- 1100 NZ2, was used to generate most of the results in this work. Additionally, particle control in a mask replication tool is addressed, with the purpose of extending the

  13. Radiographic X-Ray Pulse Jitter

    SciTech Connect

    Mitton, C. V., Good, D. E., Henderson, D. J., Hogge, K. W.

    2011-01-15

    The Dual Beam Radiographic Facility consists of two identical radiographic sources. Major components of the machines are: Marx generator, water-filled pulse-forming line (PFL), water-filled coaxial transmission line, three-cell inductive voltage adder, and rod-pinch diode. The diode pulse has the following electrical specifications: 2.25-MV, 60-kA, 60-ns. Each source has the following x-ray parameters: 1-mm-diameter spot size, 4-rad at 1 m, 50-ns full width half max. The x-ray pulse is measured with PIN diode detectors. The sources were developed to produce high resolution images on single-shot, high-value experiments. For this application it is desirable to maintain a high level of reproducibility in source output. X-ray pulse jitter is a key metric for analysis of reproducibility. We will give measurements of x-ray jitter for each machine. It is expected that x-ray pulse jitter is predominantly due to PFL switch jitter, and therefore a correlation of the two will be discussed.

  14. Ultralow-power ferroelectric memory for SoC

    NASA Astrophysics Data System (ADS)

    Natarajan, Sreedhar; Alvandpour, Atila

    2004-03-01

    The endurance of a FRAM is 1014 cycles with better retention times (>10 years). FRAM's have fast read/write access, low standby current, scalable and capable of ultra-low voltage operation. FRAM's share architectural features such as addressing schemes and I/O circuitry with other types of random access memories (DRAMs), but they have distinct features with respect to accessing the stored data, sensing, and overall circuit topology. The FRAM is a great advantage for SoC and wireless and mobile products, since it supports non-volatility but also delivers a fast memory access. Today's 1T/1C FRAM have an access time of 30 nS, a cycle time of 35 nS at 1.2 V power supply in a standard CMOS process with 2 mask adders. The cell size of a FRAM is comparable to that of a planar DRAM and is 3 - 4x denser than SRAM. This paper outlines the circuit innovations in embedded ferroelectric memories, and will cover the architecture, reference circuits, sense amplifiers, reliability issues and references to other memory technologies.

  15. An all solid state pulse power source for high PRF induction accelerators

    SciTech Connect

    Kirbie, H., LLNL

    1998-06-01

    Researchers at the Lawrence Livermore National Laboratory (LLNL) are developing a flexible, all solid-state pulsed power source that will enable an induction accelerator to produce mulitkiloampere electron beams at a maximum pulse repetition frequency (prf) of 2 MHz. The prototype source consists of three, 15-kV, 4.8-kA solid-state modulators stacked in an induction adder configuration. Each modulator contains over 1300 field-effect transistors (FETs) that quickly connect and disconnect four banks of energy storage capacitors to a magnetic induction core. The FETs are commanded on and off by an optical signal that determines the duration of the accelerating pulse. Further electronic circuitry is provided that resets the magnetic cores in each modulator immediately after the accelerating pulse. The system produces bursts of five or more pulses with an adjustable pulse width that ranges from 200 ns to 2 {micro}s The pulse duty factor within a burst can be as high as 25% while still allowing time for the induction core to reset. The solid-state modulator described above is called ARM-II and is named for the Advanced Radiographic Machine (ARM)-a powerful radiographic accelerator that will be the principal diagnostic device for the future Advanced Hydrotest Facility (AHF).

  16. A learnable parallel processing architecture towards unity of memory and computing

    PubMed Central

    Li, H.; Gao, B.; Chen, Z.; Zhao, Y.; Huang, P.; Ye, H.; Liu, L.; Liu, X.; Kang, J.

    2015-01-01

    Developing energy-efficient parallel information processing systems beyond von Neumann architecture is a long-standing goal of modern information technologies. The widely used von Neumann computer architecture separates memory and computing units, which leads to energy-hungry data movement when computers work. In order to meet the need of efficient information processing for the data-driven applications such as big data and Internet of Things, an energy-efficient processing architecture beyond von Neumann is critical for the information society. Here we show a non-von Neumann architecture built of resistive switching (RS) devices named “iMemComp”, where memory and logic are unified with single-type devices. Leveraging nonvolatile nature and structural parallelism of crossbar RS arrays, we have equipped “iMemComp” with capabilities of computing in parallel and learning user-defined logic functions for large-scale information processing tasks. Such architecture eliminates the energy-hungry data movement in von Neumann computers. Compared with contemporary silicon technology, adder circuits based on “iMemComp” can improve the speed by 76.8% and the power dissipation by 60.3%, together with a 700 times aggressive reduction in the circuit area. PMID:26271243

  17. Challenges in constructing EUV metrology tools to qualify the EUV masks for HVM implementation

    NASA Astrophysics Data System (ADS)

    Houser, David C.; Dong, Feng; Perera, Chami N.; Perera, Rupert C. C.

    2015-09-01

    Extreme Ultraviolet (EUV) Lithography is still viewed as the most promising approach for maintaining the pace of Moore's Law. Recent real achievements in EUV Lithography (EUVL) have encouraged semiconductor manufacturers to reconsider their road maps. One of the principal challenges in the ongoing EUVL implementation for high volume manufacturing (HVM) is the availability of necessary clean at wavelength metrology tools. EUV Tech is the world's leading manufacturer of at-wavelength EUV metrology equipment. Founded in 1997, EUV Tech has pioneered the development of several stand-alone inspection, metrology, and calibration tools for EUV lithographic applications that can be operated in a clean room environment on the floor of a fab. In this paper, EUV Tech's R&D program to minimize particle adders in our EUV Reflectometer along with the ongoing effort to enhance the reflectivity and wavelength, precision and accuracy required to qualify the EUV masks for HVM. In addition to preliminary results from our stand alone EUV Scatterometer developed to characterize the phase roughness of a EUV mask and the introduction of EUV Tech's Pellicle test suite for testing EUV pellicles.

  18. Hybrid VLSI/QCA Architecture for Computing FFTs

    NASA Technical Reports Server (NTRS)

    Fijany, Amir; Toomarian, Nikzad; Modarres, Katayoon; Spotnitz, Matthew

    2003-01-01

    A data-processor architecture that would incorporate elements of both conventional very-large-scale integrated (VLSI) circuitry and quantum-dot cellular automata (QCA) has been proposed to enable the highly parallel and systolic computation of fast Fourier transforms (FFTs). The proposed circuit would complement the QCA-based circuits described in several prior NASA Tech Briefs articles, namely Implementing Permutation Matrices by Use of Quantum Dots (NPO-20801), Vol. 25, No. 10 (October 2001), page 42; Compact Interconnection Networks Based on Quantum Dots (NPO-20855) Vol. 27, No. 1 (January 2003), page 32; and Bit-Serial Adder Based on Quantum Dots (NPO-20869), Vol. 27, No. 1 (January 2003), page 35. The cited prior articles described the limitations of very-large-scale integrated (VLSI) circuitry and the major potential advantage afforded by QCA. To recapitulate: In a VLSI circuit, signal paths that are required not to interact with each other must not cross in the same plane. In contrast, for reasons too complex to describe in the limited space available for this article, suitably designed and operated QCAbased signal paths that are required not to interact with each other can nevertheless be allowed to cross each other in the same plane without adverse effect. In principle, this characteristic could be exploited to design compact, coplanar, simple (relative to VLSI) QCA-based networks to implement complex, advanced interconnection schemes.

  19. A new interpolation arithmetic based readout signals process method for infrared imaging system applications

    NASA Astrophysics Data System (ADS)

    Li, Xinyi; Yao, Suying; Zhao, Yiqiang

    2009-07-01

    A new readout signals process circuit for infrared focal plane array (IR FPA) applications is proposed. In the proposed structure the continuous-time current signals from the detector array are mirrored, amplified, integrated on the integration capacitors and changed to discrete analog voltage signals. Next, these voltage signals are amplified and modulated by a group of encoded signals from the column buses, then fed to a multiple-input analog adder to generate a single serial output data stream. The generated single serial data stream is transferred to the mitigate noise circuit and is converted to digital signals by the A/D converter. For very large format detector arrays applications the speed restriction of the time-multiplexing circuitry and the A/D converter will be released. Since no scan technique has been used, all the output signals from an entire row in the detector array have been readout simultaneously without loss of optical power, the scalability of the photon-signals, the readout efficiency and the accuracy of the imaging system will be improved. Theory analysis and experimental results show that the proposed idea is reasonable and efficient. The proposed readout method is a solid option for large format infrared detector arrays and highly integrated infrared imaging system applications. In addition, the proposed idea also can be used for other active and passive imaging readout integrated circuits.

  20. Design of efficient circularly symmetric two-dimensional variable digital FIR filters

    PubMed Central

    Bindima, Thayyil; Elias, Elizabeth

    2016-01-01

    Circularly symmetric two-dimensional (2D) finite impulse response (FIR) filters find extensive use in image and medical applications, especially for isotropic filtering. Moreover, the design and implementation of 2D digital filters with variable fractional delay and variable magnitude responses without redesigning the filter has become a crucial topic of interest due to its significance in low-cost applications. Recently the design using fixed word length coefficients has gained importance due to the replacement of multipliers by shifters and adders, which reduces the hardware complexity. Among the various approaches to 2D design, transforming a one-dimensional (1D) filter to 2D by transformation, is reported to be an efficient technique. In this paper, 1D variable digital filters (VDFs) with tunable cut-off frequencies are designed using Farrow structure based interpolation approach, and the sub-filter coefficients in the Farrow structure are made multiplier-less using canonic signed digit (CSD) representation. The resulting performance degradation in the filters is overcome by using artificial bee colony (ABC) optimization. Finally, the optimized 1D VDFs are mapped to 2D using generalized McClellan transformation resulting in low complexity, circularly symmetric 2D VDFs with real-time tunability. PMID:27222739

  1. An accelerator facility for WDM, HEDP, and HIF investigations in Nazarbayev University

    NASA Astrophysics Data System (ADS)

    Kaikanov, M.; Baigarin, K.; Tikhonov, A.; Urazbayev, A.; Kwan, J. W.; Henestroza, E.; Remnev, G.; Shubin, B.; Stepanov, A.; Shamanin, V.; Waldron, W. L.

    2016-05-01

    Nazarbayev University (NU) in Astana, Kazakhstan, is planning to build a new multi-MV, ∼10 to several hundred GW/cm2 ion accelerator facility which will be used in studies of material properties at extreme conditions relevant to ion-beam-driven inertial fusion energy, and other applications. Two design options have been considered. The first option is a 1.2 MV induction linac similar to the NDCX-II at LBNL, but with modifications, capable of heating a 1 mm spot size thin targets to a few eV temperature. The second option is a 2 - 3 MV, ∼200 kA, single-gap-diode proton accelerator powered by an inductive voltage adder. The high current proton beam can be focused to ∼1 cm spot size to obtain power densities of several hundred GW/cm2, capable of heating thick targets to temperatures of tens of eV. In both cases, a common requirement to achieving high beam intensity on target and pulse length compression is to utilize beam neutralization at the final stage of beam focusing. Initial experiments on pulsed ion beam neutralization have been carried out on a 0.3 MV, 1.5 GW single-gap ion accelerator at Tomsk Polytechnic University with the goal of creating a plasma region in front of a target at densities exceeding ∼1012 cm-3.

  2. The high current, fast, 100ns, Linear Transformer Driver (LTD) developmental project at Sandia National Laboratories.

    SciTech Connect

    Ward, Kevin S.; Long, Finis W.; Sinebryukhov, Vadim A. , Tomsk, Russia); Kim, Alexandre A. , Tomsk, RUSSIA); Wakeland, Peter Eric; McKee, G. Randall; Woodworth, Joseph Ray; McDaniel, Dillon Heirman; Fowler, William E.; Mazarakis, Michael Gerrassimos; Porter, John Larry, Jr.; Struve, Kenneth William; Stygar, William A.; LeChien, Keith R.; Matzen, Maurice Keith

    2010-04-01

    Sandia National Laboratories, Albuquerque, N.M., USA, in collaboration with the High Current Electronic Institute (HCEI), Tomsk, Russia, is developing a new paradigm in pulsed power technology: the Linear Transformer Driver (LTD) technology. This technological approach can provide very compact devices that can deliver very fast high current and high voltage pulses straight out of the cavity with out any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The load may be a vacuum electron diode, a z-pinch wire array, a gas puff, a liner, an isentropic compression load (ICE) to study material behavior under very high magnetic fields, or a fusion energy (IFE) target. This is because the output pulse rise time and width can be easily tailored to the specific application needs. In this paper we briefly summarize the developmental work done in Sandia and HCEI during the last few years, and describe our new MYKONOS Sandia High Current LTD Laboratory.

  3. A learnable parallel processing architecture towards unity of memory and computing

    NASA Astrophysics Data System (ADS)

    Li, H.; Gao, B.; Chen, Z.; Zhao, Y.; Huang, P.; Ye, H.; Liu, L.; Liu, X.; Kang, J.

    2015-08-01

    Developing energy-efficient parallel information processing systems beyond von Neumann architecture is a long-standing goal of modern information technologies. The widely used von Neumann computer architecture separates memory and computing units, which leads to energy-hungry data movement when computers work. In order to meet the need of efficient information processing for the data-driven applications such as big data and Internet of Things, an energy-efficient processing architecture beyond von Neumann is critical for the information society. Here we show a non-von Neumann architecture built of resistive switching (RS) devices named “iMemComp”, where memory and logic are unified with single-type devices. Leveraging nonvolatile nature and structural parallelism of crossbar RS arrays, we have equipped “iMemComp” with capabilities of computing in parallel and learning user-defined logic functions for large-scale information processing tasks. Such architecture eliminates the energy-hungry data movement in von Neumann computers. Compared with contemporary silicon technology, adder circuits based on “iMemComp” can improve the speed by 76.8% and the power dissipation by 60.3%, together with a 700 times aggressive reduction in the circuit area.

  4. A learnable parallel processing architecture towards unity of memory and computing.

    PubMed

    Li, H; Gao, B; Chen, Z; Zhao, Y; Huang, P; Ye, H; Liu, L; Liu, X; Kang, J

    2015-01-01

    Developing energy-efficient parallel information processing systems beyond von Neumann architecture is a long-standing goal of modern information technologies. The widely used von Neumann computer architecture separates memory and computing units, which leads to energy-hungry data movement when computers work. In order to meet the need of efficient information processing for the data-driven applications such as big data and Internet of Things, an energy-efficient processing architecture beyond von Neumann is critical for the information society. Here we show a non-von Neumann architecture built of resistive switching (RS) devices named "iMemComp", where memory and logic are unified with single-type devices. Leveraging nonvolatile nature and structural parallelism of crossbar RS arrays, we have equipped "iMemComp" with capabilities of computing in parallel and learning user-defined logic functions for large-scale information processing tasks. Such architecture eliminates the energy-hungry data movement in von Neumann computers. Compared with contemporary silicon technology, adder circuits based on "iMemComp" can improve the speed by 76.8% and the power dissipation by 60.3%, together with a 700 times aggressive reduction in the circuit area. PMID:26271243

  5. Phase defect mitigation strategy: fiducial mark requirements on extreme ultraviolet lithography mask

    NASA Astrophysics Data System (ADS)

    Murachi, Tetsunori; Amano, Tsuyoshi; Oh, Sung Hyun

    2012-03-01

    For Extreme Ultra-Violet Lithography (EUVL), fabrication of defect free multi-layered (ML) mask blanks is one of the difficult challenges. ML defects come from substrate defects and adders during ML coating, cannot be removed, and are called as phase defect. If we can accept ML blanks with certain number of phase defects, the blank yield will be drastically up. In order to use such blanks, the phase defects need to be identified and located during ML blank defect inspection before absorber patterning. To locate phase defects on the blanks accurately and precisely, Fiducial Marks (FM) on ML blanks are needed for mask alignment and defect location information. The proposed requirement of defect location accuracy is <=20 nm [1]. In this paper, we will present the result of feasibility study on the requirements of FM on EUVL mask by simulations & experiments to establish the phase defect mitigation method with EUV Actinic Blank Inspection (ABI) tool. And the optimum ranges of FM line width, depth, and fabrication method on EUVL mask based on above results are >= 5 um line width, >= 100 nm depth FM etched into ML respectively, and additional finer FMs for magnified optics.

  6. Public health aspects of snakebite care in West Africa: perspectives from Nigeria.

    PubMed

    Habib, Abdulrazaq G

    2013-01-01

    Snakebite envenoming is a major public health problem among rural communities of the Nigerian savanna. The saw-scaled or carpet viper (Echis ocellatus) and, to a lesser extent, the African cobras (Naja spp.) and puff adders (Bitis arietans) have proved to be the most important cause of mortality and morbidity. The main clinical features of E. ocellatus envenoming are systemic hemorrhage, incoagulable blood, shock, local swelling, bleeding and, occasionally, necrosis. Bites may be complicated by amputation, blindness, disability, disfigurement, mutilation, tissue destruction and psychological consequences. Antivenom remains the hallmark and mainstay of envenoming management while studies in Nigeria confirm its protection of over 80% against mortality from carpet-viper bites. However, the availability, distribution and utilization of antivenom remain challenging although two new antivenoms (monospecific EchiTab G and trispecific EchiTab ICP-Plus) derived from Nigerian snake venoms have proven very effective and safe in clinical trials. A hub-and-spoke strategy is suggested for broadening antivenom access to endemic rural areas together with instituting quality assurance, standardization and manpower training. With the advent of antivenomics, national health authorities must be aided in selecting and purchasing antivenoms appropriate to their national needs while manufacturers should be helped in practical ways to improve the safety, efficacy and potential coverage against snake venoms and pricing of their products. PMID:24134780

  7. Identification of cDNAs encoding viper venom hyaluronidases: cross-generic sequence conservation of full-length and unusually short variant transcripts.

    PubMed

    Harrison, Robert A; Ibison, Frances; Wilbraham, Davina; Wagstaff, Simon C

    2007-05-01

    The immobilisation of prey by snakes is most efficiently achieved by the rapid dissemination of venom from its site of injection into the blood stream. Hyaluronidase is a common component of snake venoms and has been termed the "venom spreading factor". In the absence of nucleotide or protein sequence data to confirm the functional identity of this venom component, we interrogated a venom gland EST database for the saw-scaled viper, Echis ocellatus (Nigeria), using the gene ontology (GO) term "carbohydrate metabolism". A single hyalurononglucosaminadase-activity matching sequence (EOC00242) was found and used to design PCR primers to acquire the full-length cDNA sequence. Although very different from the bee venom and mammalian hyaluronidase sequences, the E. ocellatus sequence retained all the catalytic, positional and structural residues that characterise this class of carbohydrate metabolising hydrolases. An extraordinarily high level of sequence identity (>95%) was observed in analogous venom gland cDNA sequences isolated (by PCR) from another saw-scaled viper species, E. pyramidum leakeyi (Kenya), and from the sahara horned viper, Cerastes cerastes cerastes (Egypt) and the puff adder, Bitis arietans (Nigeria). Smaller amplicons, lacking hyaluronidase catalytic residues because of 768 bp or 855 bp central deletions, appear to encode either truncated peptides without hyaluronidase activity, or are non-translated transcripts because they lack consensus translation initiating motifs. PMID:17210232

  8. Public health aspects of snakebite care in West Africa: perspectives from Nigeria

    PubMed Central

    2013-01-01

    Snakebite envenoming is a major public health problem among rural communities of the Nigerian savanna. The saw-scaled or carpet viper (Echis ocellatus) and, to a lesser extent, the African cobras (Naja spp.) and puff adders (Bitis arietans) have proved to be the most important cause of mortality and morbidity. The main clinical features of E. ocellatus envenoming are systemic hemorrhage, incoagulable blood, shock, local swelling, bleeding and, occasionally, necrosis. Bites may be complicated by amputation, blindness, disability, disfigurement, mutilation, tissue destruction and psychological consequences. Antivenom remains the hallmark and mainstay of envenoming management while studies in Nigeria confirm its protection of over 80% against mortality from carpet-viper bites. However, the availability, distribution and utilization of antivenom remain challenging although two new antivenoms (monospecific EchiTab G and trispecific EchiTab ICP-Plus) derived from Nigerian snake venoms have proven very effective and safe in clinical trials. A hub-and-spoke strategy is suggested for broadening antivenom access to endemic rural areas together with instituting quality assurance, standardization and manpower training. With the advent of antivenomics, national health authorities must be aided in selecting and purchasing antivenoms appropriate to their national needs while manufacturers should be helped in practical ways to improve the safety, efficacy and potential coverage against snake venoms and pricing of their products. PMID:24134780

  9. A new architecture of current-mode CMOS TDI Sensor

    NASA Astrophysics Data System (ADS)

    Ji, Cheng; Chen, Yongping

    2015-10-01

    Nowadays, CMOS sensors still suffer from the problem of low SNR, especially in the stage of low illumination and high relative scanning velocity. Lots of methods have been develop to overcome this problem. Among these researches, TDI (Time Delay Integration) architecture is a more natural choice, which is natively supported by CCD sensors. In this paper a new kind of proposed current-mode sensor is used to achieve TDI operation in analog domain. The circuit is composed of three main parts. At first, a current-type pixel is proposed, in which the active MOSFET is operated in the triode region to ensure the output current is linearly dependent on the gate voltage and avoid the reduction of threshold voltage in the traditional voltage mode pixels, such as 3T, 4T which use the source followers as its active part. Then a discrete double sampling (DDS) unit, which is operated in the form of currents is used to efficiently reduce the fixed pattern noise (FPN) and make the output is independent of reset voltage of pixels. For accumulation, an improved current mirror adder under controlled of timing circuits is proposed to overcome the problem of saturation suffered in voltage domain. Some main noise sources, especially come from analog sample and holds capacitors and switches is analyzed. Finally, simulation results with CSMC 0.5um technology and Cadence IC show that the proposed method is reasonable and efficient to improve the SNR.

  10. Impedance Dynamics in the Self-Magnetic Pinch (SMP) Diode on the RITS-6 Accelerator

    NASA Astrophysics Data System (ADS)

    Renk, Timothy; Johnston, Mark; Leckbee, Joshua; Webb, Timothy; Mazarakis, Michael; Kiefer, Mark; Bennett, Nichelle

    2014-10-01

    The RITS-6 inductive voltage adder (IVA) accelerator (3.5-8.5 MeV) at Sandia National Laboratories produces high-power (TW) focused electron beams (<3 mm diameter) for flash x-ray radiography applications. The Self-Magnetic Pinch (SMP) diode utilizes a hollowed metal cathode to produce a pinched focus onto a high Z metal converter. The electron flow from the IVA driver into the load region complicates understanding of diode evolution. There is growing evidence that reducing cathode size below some ``optimum'' value in order to achieve desired spot size reduction results in pinch instabilities leading to either reduced dose-rate, early radiation power termination, or both. We are studying evolving pinch dynamics with current and x-ray monitors, optical diagnostics, and spectroscopy, as well as with LSP [1] code simulations. We are also planning changes to anode-cathode materials as well as changes to the diode aspect ratio in an attempt to mitigate the above trends and improve pinch stability while achieving simultaneous spot size reduction. Experiments are ongoing, and latest results will be reported [1]. LSP is a software product of ATK Mission Research, Albuquerque, NM. Sandia National Laboratories is a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Adminis-tration under Contract DE-AC04-94AL85000.

  11. Cygnus Diverter Switch Analysis

    SciTech Connect

    G. Corrow, M. Hansen, D. Henderson, C. Mitton et al.

    2008-02-01

    The Cygnus Dual Beam Radiographic Facility consists of two 2.25-MV, 60-kA, 50-ns x-ray sources fielded in an underground laboratory at the Nevada Test Site. The tests performed in this laboratory involve study of the dynamic properties of plutonium and are called subcritical experiments. From end-to-end, the Cygnus machines utilize the following components: Marx generator, water-filled pulse-forming line (PFL), waterfilled coaxial transmission line (WTL), 3-cell inductive voltage adder (IVA), and rod-pinch diode. The upstream WTL interface to the PFL is via a radial insulator with coaxial geometry. The downstream WTL terminates in a manifold where the center conductor splits into three lines which individually connect to each of the IVA cell inputs. There is an impedance mismatch at this juncture. It is a concern that a reflected pulse due to anomalous behavior in the IVA or diode might initiate breakdown upon arrival at the upstream PFL/WTL insulator. Therefore near the beginning of the WTL a radial diverter switch is installed to protect the insulator from over voltage and breakdown. The diverter has adjustable gap spacing, and an in-line aqueous-solution (sodium thiosulfate) resistor array for energy dissipation. There are capacitive voltage probes at both ends of the WTL and on the diverter switch. These voltage signals will be analyzed to determine diverter performance. Using this analysis the usefulness of the diverter switch will be evaluated.

  12. Nanoimprint system development and status for high volume semiconductor manufacturing

    NASA Astrophysics Data System (ADS)

    Takeishi, Hiroaki; Sreenivasan, S. V.

    2015-03-01

    Imprint lithography has been shown to be an effective technique for replication of nano-scale features. Jet and Flash Imprint Lithography (J-FIL) involves the field-by-field deposition and exposure of a low viscosity resist deposited by jetting technology onto the substrate. The patterned mask is lowered into the fluid which then quickly flows into the relief patterns in the mask by capillary action. Following this filling step, the resist is cross-linked under UV radiation, and then the mask is removed, leaving a patterned resist on the substrate. Criteria specific to any lithographic process for the semiconductor industry include overlay, throughput and defectivity. The purpose of this paper is to describe the technology advancements made and introduce the new imprint systems that will be applied for the fabrication of advanced devices such as NAND Flash memory and DRAM. Overlay of better than 5nm (mean + 3sigma) has been demonstrated, and throughputs of 10 wafers per imprint station are now routinely achieved. Defectivity has been reduced by more than two orders of magnitude and particle adders within the tool have come down by approximately four orders of magnitude. A pilot line tool, the FPA-1100 NZ2, was used to generate most of the results in this work and conceptual plans are in place to address the requirements necessary for high volume manufacturing with an attractive cost of ownership relative to other HVM solutions for the semiconductor industry.

  13. Design of efficient circularly symmetric two-dimensional variable digital FIR filters.

    PubMed

    Bindima, Thayyil; Elias, Elizabeth

    2016-05-01

    Circularly symmetric two-dimensional (2D) finite impulse response (FIR) filters find extensive use in image and medical applications, especially for isotropic filtering. Moreover, the design and implementation of 2D digital filters with variable fractional delay and variable magnitude responses without redesigning the filter has become a crucial topic of interest due to its significance in low-cost applications. Recently the design using fixed word length coefficients has gained importance due to the replacement of multipliers by shifters and adders, which reduces the hardware complexity. Among the various approaches to 2D design, transforming a one-dimensional (1D) filter to 2D by transformation, is reported to be an efficient technique. In this paper, 1D variable digital filters (VDFs) with tunable cut-off frequencies are designed using Farrow structure based interpolation approach, and the sub-filter coefficients in the Farrow structure are made multiplier-less using canonic signed digit (CSD) representation. The resulting performance degradation in the filters is overcome by using artificial bee colony (ABC) optimization. Finally, the optimized 1D VDFs are mapped to 2D using generalized McClellan transformation resulting in low complexity, circularly symmetric 2D VDFs with real-time tunability. PMID:27222739

  14. A precision analogue integrator system for heavy current measurement in MFDC resistance spot welding

    NASA Astrophysics Data System (ADS)

    Xia, Yu-Jun; Zhang, Zhong-Dian; Xia, Zhen-Xin; Zhu, Shi-Liang; Zhang, Rui

    2016-02-01

    In order to control and monitor the quality of middle frequency direct current (MFDC) resistance spot welding (RSW), precision measurement of the welding current up to 100 kA is required, for which Rogowski coils are the only viable current transducers at present. Thus, a highly accurate analogue integrator is the key to restoring the converted signals collected from the Rogowski coils. Previous studies emphasised that the integration drift is a major factor that influences the performance of analogue integrators, but capacitive leakage error also has a significant impact on the result, especially in long-time pulse integration. In this article, new methods of measuring and compensating capacitive leakage error are proposed to fabricate a precision analogue integrator system for MFDC RSW. A voltage holding test is carried out to measure the integration error caused by capacitive leakage, and an original integrator with a feedback adder is designed to compensate capacitive leakage error in real time. The experimental results and statistical analysis show that the new analogue integrator system could constrain both drift and capacitive leakage error, of which the effect is robust to different voltage levels of output signals. The total integration error is limited within  ±0.09 mV s-1 0.005% s-1 or full scale at a 95% confidence level, which makes it possible to achieve the precision measurement of the welding current of MFDC RSW with Rogowski coils of 0.1% accuracy class.

  15. High speed multiplier using Nikhilam Sutra algorithm of Vedic mathematics

    NASA Astrophysics Data System (ADS)

    Pradhan, Manoranjan; Panda, Rutuparna

    2014-03-01

    This article presents the design of a new high-speed multiplier architecture using Nikhilam Sutra of Vedic mathematics. The proposed multiplier architecture finds out the compliment of the large operand from its nearest base to perform the multiplication. The multiplication of two large operands is reduced to the multiplication of their compliments and addition. It is more efficient when the magnitudes of both operands are more than half of their maximum values. The carry save adder in the multiplier architecture increases the speed of addition of partial products. The multiplier circuit is synthesised and simulated using Xilinx ISE 10.1 software and implemented on Spartan 2 FPGA device XC2S30-5pq208. The output parameters such as propagation delay and device utilisation are calculated from synthesis results. The performance evaluation results in terms of speed and device utilisation are compared with earlier multiplier architecture. The proposed design has speed improvements compared to multiplier architecture presented in the literature.

  16. FAST TRACK COMMUNICATION: Reversible arithmetic logic unit for quantum arithmetic

    NASA Astrophysics Data System (ADS)

    Kirkedal Thomsen, Michael; Glück, Robert; Axelsen, Holger Bock

    2010-09-01

    This communication presents the complete design of a reversible arithmetic logic unit (ALU) that can be part of a programmable reversible computing device such as a quantum computer. The presented ALU is garbage free and uses reversible updates to combine the standard reversible arithmetic and logical operations in one unit. Combined with a suitable control unit, the ALU permits the construction of an r-Turing complete computing device. The garbage-free ALU developed in this communication requires only 6n elementary reversible gates for five basic arithmetic-logical operations on two n-bit operands and does not use ancillae. This remarkable low resource consumption was achieved by generalizing the V-shape design first introduced for quantum ripple-carry adders and nesting multiple V-shapes in a novel integrated design. This communication shows that the realization of an efficient reversible ALU for a programmable computing device is possible and that the V-shape design is a very versatile approach to the design of quantum networks.

  17. Modeling magnetically insulated devices using flow impedance

    SciTech Connect

    Mendel, C.W. Jr.; Rosenthal, S.E. )

    1995-04-01

    In modern pulsed power systems the electric field stresses at metal surfaces in vacuum transmission lines are so high that negative surfaces are space-charge-limited electron emitters. These electrons do not cause unacceptable losses because magnetic fields due to system currents result in net motion parallel to the electrodes. It has been known for several years that a parameter known as flow impedance is useful for describing these flows. Flow impedance is a measure of the separation between the anode and the mean position of the electron cloud, and it will be shown in this paper that in many situations flow impedance depends upon the geometry of the transmission line upstream of the point of interest. It can be remarkably independent of other considerations such as line currents and voltage. For this reason flow impedance is a valuable design parameter. Models of impedance transitions and voltage adders using flow impedance will be developed. Results of these models will be compared to two-dimensional, time-dependent, particle-in-cell simulations.

  18. Optimization Approaches for Designing a Novel 4-Bit Reversible Comparator

    NASA Astrophysics Data System (ADS)

    Zhou, Ri-gui; Zhang, Man-qun; Wu, Qian; Li, Yan-cheng

    2013-02-01

    Reversible logic is a new rapidly developed research field in recent years, which has been receiving much attention for calculating with minimizing the energy consumption. This paper constructs a 4×4 new reversible gate called ZRQ gate to build quantum adder and subtraction. Meanwhile, a novel 1-bit reversible comparator by using the proposed ZRQC module on the basis of ZRQ gate is proposed as the minimum number of reversible gates and quantum costs. In addition, this paper presents a novel 4-bit reversible comparator based on the 1-bit reversible comparator. One of the vital important for optimizing reversible logic is to design reversible logic circuits with the minimum number of parameters. The proposed reversible comparators in this paper can obtain superiority in terms of the number of reversible gates, input constants, garbage outputs, unit delays and quantum costs compared with the existed circuits. Finally, MATLAB simulation software is used to test and verify the correctness of the proposed 4-bit reversible comparator.

  19. Mixed Source Interrogation of Steel Shielded Special Nuclear Material Using an Intense Pulsed Source

    NASA Astrophysics Data System (ADS)

    Hill, C.; Clemett, C. D.; Campbell, B.; Martin, P. N.; Threadgold, J.; O'Malley, J.

    This paper explores the benefits of using a mixed photon and neutron radiation source for active detection of special nuclear material. More than fifty irradiations were performed using an 8 MV electron accelerator employing and induction voltage adder (IVA). The experiments used a high atomic number converter to produce a Bremsstrahlung photon spectrum which was then used to create a neutron source via a nuclear interaction with heavy water (deuterium oxide, D2O). This mixed particle source was used to irradiate a depleted uranium (DU) sample, inducing fission in the sample. Several thicknesses of steel shielding were tested in order to compare the performance of the mixed photon and neutron source to a Bremsstrahlung-only source. An array of detectors were fielded to record both photons and neutrons emitted by the fission reactions. A correlation between steel shielding and a detection figure-of-merit can be seen in all cases where the Bremsstrahlung-only source was used. The same relationship for the mixed photon-neutron source is less consistent. The data collected from the fielded detectors is compared to MCNP6 calculations and good agreement is found.

  20. Investigation of a Novel Common Subexpression Elimination Method for Low Power and Area Efficient DCT Architecture

    PubMed Central

    Siddiqui, M. F.; Reza, A. W.; Kanesan, J.; Ramiah, H.

    2014-01-01

    A wide interest has been observed to find a low power and area efficient hardware design of discrete cosine transform (DCT) algorithm. This research work proposed a novel Common Subexpression Elimination (CSE) based pipelined architecture for DCT, aimed at reproducing the cost metrics of power and area while maintaining high speed and accuracy in DCT applications. The proposed design combines the techniques of Canonical Signed Digit (CSD) representation and CSE to implement the multiplier-less method for fixed constant multiplication of DCT coefficients. Furthermore, symmetry in the DCT coefficient matrix is used with CSE to further decrease the number of arithmetic operations. This architecture needs a single-port memory to feed the inputs instead of multiport memory, which leads to reduction of the hardware cost and area. From the analysis of experimental results and performance comparisons, it is observed that the proposed scheme uses minimum logic utilizing mere 340 slices and 22 adders. Moreover, this design meets the real time constraints of different video/image coders and peak-signal-to-noise-ratio (PSNR) requirements. Furthermore, the proposed technique has significant advantages over recent well-known methods along with accuracy in terms of power reduction, silicon area usage, and maximum operating frequency by 41%, 15%, and 15%, respectively. PMID:25133249

  1. Area and power efficient DCT architecture for image compression

    NASA Astrophysics Data System (ADS)

    Dhandapani, Vaithiyanathan; Ramachandran, Seshasayanan

    2014-12-01

    The discrete cosine transform (DCT) is one of the major components in image and video compression systems. The final output of these systems is interpreted by the human visual system (HVS), which is not perfect. The limited perception of human visualization allows the algorithm to be numerically approximate rather than exact. In this paper, we propose a new matrix for discrete cosine transform. The proposed 8 × 8 transformation matrix contains only zeros and ones which requires only adders, thus avoiding the need for multiplication and shift operations. The new class of transform requires only 12 additions, which highly reduces the computational complexity and achieves a performance in image compression that is comparable to that of the existing approximated DCT. Another important aspect of the proposed transform is that it provides an efficient area and power optimization while implementing in hardware. To ensure the versatility of the proposal and to further evaluate the performance and correctness of the structure in terms of speed, area, and power consumption, the model is implemented on Xilinx Virtex 7 field programmable gate array (FPGA) device and synthesized with Cadence® RTL Compiler® using UMC 90 nm standard cell library. The analysis obtained from the implementation indicates that the proposed structure is superior to the existing approximation techniques with a 30% reduction in power and 12% reduction in area.

  2. Design and implementation of low power clock gated 64-bit ALU on ultra scale FPGA

    NASA Astrophysics Data System (ADS)

    Gupta, Ashutosh; Murgai, Shruti; Gulati, Anmol; Kumar, Pradeep

    2016-03-01

    64-bit energy efficient Arithmetic and Logic Unit using negative latch based clock gating technique is designed in this paper. The 64-bit ALU is designed using multiplexer based full adder cell. We have designed a 64-bit ALU with a gated clock. We have used negative latch based circuit for generating gated clock. This gated clock is used to control the multiplexer based 64-bit ALU. The circuit has been synthesized on kintex FPGA through Xilinx ISE Design Suite 14.7 using 28 nm technology in Verilog HDL. The circuit has been simulated on Modelsim 10.3c. The design is verified using System Verilog on QuestaSim in UVM environment. We have achieved 74.07%, 92. 93% and 95.53% reduction in total clock power, 89.73%, 91.35% and 92.85% reduction in I/Os power, 67.14%, 62.84% and 74.34% reduction in dynamic power and 25.47%, 29.05% and 46.13% reduction in total supply power at 20 MHz, 200 MHz and 2 GHz frequency respectively. The power has been calculated using XPower Analyzer tool of Xilinx ISE Design Suite 14.3.

  3. Ring Counter Based ATPG for Low Transition Test Pattern Generation

    PubMed Central

    Begam, V. M. Thoulath; Baulkani, S.

    2015-01-01

    In test mode test patterns are applied in random fashion to the circuit under circuit. This increases switching transition between the consecutive test patterns and thereby increases dynamic power dissipation. The proposed ring counter based ATPG reduces vertical switching transitions by inserting test vectors only between the less correlative test patterns. This paper presents the RC-ATPG with an external circuit. The external circuit consists of XOR gates, full adders, and multiplexers. First the total number of transitions between the consecutive test patterns is determined. If it is more, then the external circuit generates and inserts test vectors in between the two test patterns. Test vector insertion increases the correlation between the test patterns and reduces dynamic power dissipation. The results prove that the test patterns generated by the proposed ATPG have fewer transitions than the conventional ATPG. Experimental results based on ISCAS'85 and ISCAS'89 benchmark circuits show 38.5% reduction in the average power and 50% reduction in the peak power attained during testing with a small size decoding logic. PMID:26075295

  4. Development of high frequency spice models for ferrite core inductors and transformers

    SciTech Connect

    Muyshondt, G.P.; Portnoy, W.M. . Dept. of Electrical Engineering)

    1989-01-01

    In this work high frequency SPICE models were developed to simulate the hysteresis and saturation effects of toroidal shaped ferrite core inductors and transformers. The models include the nonlinear, multi-valued B-H characteristic of the core material, leakage flux, stray capacitances, and core losses. The saturation effects were modeled using two diode clamping arrangements in conjunction with nonlinear dependent sources. Two possible controlling schemes were developed for the saturation switch. One of the arrangements used the current flowing through a series RC branch to control the switch, while the other used a NAND gate. The NAND gate implementation of the switch proved to be simpler and the parameters associated with it were easier to determine from the measurements and the B-H characteristics of the material. Lumped parameters were used to simulate the parasitic effects. Techniques for measuring these parasitic are described. The models were verified using manganese-zinc ferrite-type toroidal cores and they have general applicability to all circuit analysis codes equivalent function blocks such as multipliers, adders, and logic components. 7 refs., 22 figs.

  5. A 6 kV arbitrary waveform generator for the Tevatron Electron Lens

    SciTech Connect

    Pfeffer, H.; Saewert, G.

    2011-11-09

    This paper reports on a 6 kV modulator built and installed at Fermilab to drive the electron gun anode for the Tevatron Electron Lens (TEL). The TEL was built with the intention of shifting the individual (anti)proton bunch tunes to even out the tune spread among all 36 bunches with the desire of improving Tevatron integrated luminosity. This modulator is essentially a 6 kV arbitrary waveform generator that enables the TEL to define the electron beam intensity on a bunch-by-bunch basis. A voltage waveform is constructed having a 7 μs duration that corresponds to the tune shift requirements of a 12-bunch (anti)proton beam pulse train. This waveform is played out for any one or all three bunch trains in the Tevatron. The programmed waveform voltages transition to different levels at time intervals corresponding to the 395 ns bunch spacing. In addition, complex voltage waveforms can be played out at a sustained rate of 143 kHz over the full 6 kV output range. This paper describes the novel design of the inductive adder topology employing five transformers. It describes the design aspects that minimize switching losses for this multi-kilovolt, high repetition rate and high duty factor application.

  6. Star sensing for an earth imaging sensor

    NASA Technical Reports Server (NTRS)

    Ellis, Kenneth K. (Inventor); Griffith, Paul C. (Inventor)

    2012-01-01

    A star sensor includes (a) a scan mirror for scanning at least one star; (b) a detector array, coupled to the scan mirror, for detecting the one star; and (c) a processor, coupled to the detector array. The processor includes a first filter configured to reduce noise spikes in the detected one star, and provide a detection mask of filtered data. Also included is a second filter configured to reduce non-contiguous samples in the detection mask. A centroid calculator is included to determine a location of the one star, after the first and second filtering. The first filter includes a median filter, followed by an averaging filter, both configured to filter the one star in an along-scan direction of the scan mirror. The first filter includes another median filter, which is configured to filter the detected one star in the cross-scan direction of the scan mirror. An adder is included to subtract (a) output data from the other median filter from (b) output data from the averaging filter and provide filtered star data to the second filter.

  7. Programmable pipelined image processor

    NASA Technical Reports Server (NTRS)

    Gennery, Donald B. (Inventor); Wilcox, Brian (Inventor)

    1988-01-01

    A pipelined image processor selectively interconnects modules in a column of a two-dimensional array to modules of the next column of the array of modules 1,1 through M,N, where M is the number of modules in one dimension and N is the number of modules in the other direction. Each module includes two input selectors for A and B inputs, two convolvers, a binary function operator, a neighborhood comparison operator which produces an A output and an output selector which may select as a B output the output of any one of the components in the module, including the A output of the neighborhood comparison operator. Each module may be connected to as many as eight modules in the next column, preferably with the majority always in a different row that is up (or down) in the array for a generally spiral data path around the torus thus formed. The binary function operator is implemented as a look-up table addressed by the most significant 8 bits of each 12-bit argument. The table output includes a function value and the slopes for interpolation of the two arguments by multiplying the 4 least significant bits in multipliers and adding the products to the function value through adders.

  8. Integrating logic functions inside a single molecule

    NASA Astrophysics Data System (ADS)

    Stadler, R.; Ami, S.; Joachim, C.; Forshaw, M.

    2004-04-01

    In Stadler et al (2003 Nanotechnology 14 138), a scheme for a molecular memory was presented. It was based on the influence of the positions of chemical side-groups attached to aromatic molecules on the paths for electrons propagating through these molecules in the ballistic and tunnelling transport regimes. Here we extend this concept in the following ways. (i) A graphical method is derived from an electron scattering formalism based on a topological Hückel description, which allows us to estimate whether the electron transport between two electrodes attached to specific atomic sites in an arbitrary molecule is finite or zero at the Fermi level. (ii) The same scheme that was used for the implementation of the molecular memory is extended to logic functions, in particular a half-adder. (iii) A more realistic description of the chemical nature of the proposed intra-molecular circuits is achieved by using the elastic scattering quantum chemistry (ESQC) technique in an extended Hückel implementation and by specifying the side-groups as nitro-groups, which are rotated in order to feed the signal inputs into the computational circuit.

  9. DARPA/TTO program IR binary optics

    NASA Astrophysics Data System (ADS)

    Veldkamp, W. B.

    1984-06-01

    Binary grating optics consist of microfine rectangular (high-low) relief patterns on a dielectric or a metallic surface. By controlling the depth, width and periodicity of the binary pattern, the amplitude and the phase of an electromagnetic wave can be controlled to produce a variety of optical transfer functions. The lithographic tools for fabrication of binary optics are the ones developed for VLSI circuit fabrication. From a single lithographic mask, planar replica optics can be made in quantity. This technology has broad applicability for tactical missile systems as well as for space systems. In addition to making optics cheaper than by conventional means, binary optics allows the fabrication of unique devices that cannot be made conventionally. These include high-speed rotary scanners, multiplexers, filters, beam shapers and coherent laser adders. The goal of this program is the development of high quality planar optical components using VLSI circuit fabrication techniques. The main elements of the plan are: (1) the development of large aperture segmented and piezoelectrically active planar optical surfaces, (2) the development of raster scanning laser telescopes and extension to broadband applications, and (3) the application of diffractive optics technology to the coherent addition of beams from modular laser systems. This report covers progress in the setup of a reactive ion-beam etching laboratory, and the feasibility demonstrations of the coherent beam addition concept with gas lasers.

  10. Research on pinching characteristics of electron beams emitted from different cathode surfaces of a rod-pinch diode

    NASA Astrophysics Data System (ADS)

    Gao, Yi; Qiu, Aici; Zhang, Zhong; Zhang, Pengfei; Wang, Zhiguo; Yang, Hailiang

    2010-07-01

    The particle-in-cell code UNIPIC is used to simulate the working process of a rod-pinch diode and investigate the pinching characteristics of electron beams emitted from different cathode surfaces. The simulation results indicate that the electron beam emitted from the upstream surface pinches better than from other surfaces when all the three surfaces emit electrons. The charge-density deposition on the anode surface peaks at the rod tip while the deposited charge density is approximately uniform over the first 15 mm of the rod before rapidly increasing over the last 3 mm, indicating a large axial extent of electron deposition. For the case of single-surface emission, the pinching quality of the electron beam emitted from the downstream surface is better than those from other surfaces. The charge-density deposition peaks at the rod tip and decreases rapidly off the tip. Based on the relationship of Larmor radius, beam's self-magnetic field, and the spatial current distribution, the above simulation results are analyzed theoretically. The experiments are performed on the inductive voltage adder to examine the simulations. By comparing the axial distribution of the radiation on the anode rod measured with the pinhole camera and the on-axis forward x-ray dose measured with the LiF thermoluminescent detectors, the simulation results are verified. The electron emission suppression method and the impedance change for each case are investigated or discussed in this paper.

  11. Recent advances in the development of high average power induction accelerators for industrial and environmental applications

    SciTech Connect

    Neau, E.L.

    1994-09-01

    Short-pulse accelerator technology developed during the early 1960`s through the late 1980`s is being extended to high average power systems capable of use in industrial and environmental applications. Processes requiring high dose levels and/or high volume throughput will require systems with beam power levels from several hundreds of kilowatts to megawatts. Beam accelerating potentials can range from less than 1 MeV to as much as 10 MeV depending on the type of beam, depth of penetration required, and the density of the product being treated. This paper addresses the present status of a family of high average power systems, with output beam power levels up to 200 kW, now in operation that use saturable core switches to achieve output pulse widths of 50 to 80 nanoseconds. Inductive adders and field emission cathodes are used to generate beams of electrons or x-rays at up to 2.5 MeV over areas of 1000 cm{sup 2}. Similar high average power technology is being used at {le} 1 MeV to drive repetitive ion beam sources for treatment of material surfaces over 100`s of cm{sup 2}.

  12. A review of accelerator concepts for the Advanced Hydrotest Facility

    SciTech Connect

    Toepfer, A.J.

    1998-08-01

    The Advanced Hydrotest Facility (AHF) is a facility under consideration by the Department of Energy (DOE) for conducting explosively-driven hydrodynamic experiments. The major diagnostic tool at AHF will be a radiography accelerator having radiation output capable of penetrating very dense dynamic objects on multiple viewing axes with multiple pulses on each axis, each pulse having a time resolution capable of freezing object motion ({approx}50-ns) and achieving a spatial resolution {approx}1 mm at the object. Three accelerator technologies are being considered for AHF by the DOE national laboratories at Los Alamos (LANL), Livermore (LLNL), and Sandia (SNL). Two of these are electron accelerators that will produce intense x-ray pulses from a converter target yielding a dose {approx}1,000--2,000 Rads {at} 1 meter. LLNL has proposed a 16--20 MeV, 3--6 kA linear induction accelerator (LIA) driven by FET-switched modulators driving metglas loaded cavities. SNL has proposed a 12-MeV, 40-kA Inductive Voltage Adder (IVA) accelerator based on HERMES III pulsed power technology. The third option is a 25--50-GeV proton accelerator capable of {approx}10{sup 13} protons/pulse proposed by LANL. This paper will review the current status of the three accelerator concepts for AHF.

  13. A 6 kV arbitrary waveform generator for the Tevatron Electron Lens

    DOE PAGESBeta

    Pfeffer, H.; Saewert, G.

    2011-11-09

    This paper reports on a 6 kV modulator built and installed at Fermilab to drive the electron gun anode for the Tevatron Electron Lens (TEL). The TEL was built with the intention of shifting the individual (anti)proton bunch tunes to even out the tune spread among all 36 bunches with the desire of improving Tevatron integrated luminosity. This modulator is essentially a 6 kV arbitrary waveform generator that enables the TEL to define the electron beam intensity on a bunch-by-bunch basis. A voltage waveform is constructed having a 7 μs duration that corresponds to the tune shift requirements of amore » 12-bunch (anti)proton beam pulse train. This waveform is played out for any one or all three bunch trains in the Tevatron. The programmed waveform voltages transition to different levels at time intervals corresponding to the 395 ns bunch spacing. In addition, complex voltage waveforms can be played out at a sustained rate of 143 kHz over the full 6 kV output range. This paper describes the novel design of the inductive adder topology employing five transformers. It describes the design aspects that minimize switching losses for this multi-kilovolt, high repetition rate and high duty factor application.« less

  14. Highly Uniform Carbon Nanotube Field-Effect Transistors and Medium Scale Integrated Circuits.

    PubMed

    Chen, Bingyan; Zhang, Panpan; Ding, Li; Han, Jie; Qiu, Song; Li, Qingwen; Zhang, Zhiyong; Peng, Lian-Mao

    2016-08-10

    Top-gated p-type field-effect transistors (FETs) have been fabricated in batch based on carbon nanotube (CNT) network thin films prepared from CNT solution and present high yield and highly uniform performance with small threshold voltage distribution with standard deviation of 34 mV. According to the property of FETs, various logical and arithmetical gates, shifters, and d-latch circuits were designed and demonstrated with rail-to-rail output. In particular, a 4-bit adder consisting of 140 p-type CNT FETs was demonstrated with higher packing density and lower supply voltage than other published integrated circuits based on CNT films, which indicates that CNT based integrated circuits can reach to medium scale. In addition, a 2-bit multiplier has been realized for the first time. Benefitted from the high uniformity and suitable threshold voltage of CNT FETs, all of the fabricated circuits based on CNT FETs can be driven by a single voltage as small as 2 V. PMID:27459084

  15. Integrated cleaning and handling automation of NXE3100 reticles

    NASA Astrophysics Data System (ADS)

    Jonckheere, Rik; Waehler, Tobias; Baudemprez, Bart; Dietze, Uwe; Dress, Peter; Brux, Oliver; Ronse, Kurt

    2012-02-01

    This paper focuses on imec's activities to minimize particle contamination on reticles (front- and backside) for the latest EUVL scanner, i.e. the NXE3100. Mask cleaning is performed on the HamaTech MaskTrack Pro® (MTP). Although also front-side particles and other contamination are being tackled by cleaning, the prime purpose is the avoidance of back-side particles which would lead to unacceptable overlay performance of the scanner and hence create yield loss, as well as cause unscheduled scanner down situations for cleaning of the reticle clamp. In the absence of a soft pellicle, the present approach to minimize particle adders during handling is to load EUV reticles into the scanner via so-called dual pods. The inner pod as such acts as a removable hard pellicle. Through the installation of the HamaTech MaskTrack Pro InSync® tool, interfaced to the MaskTrack Pro Cleaner, automated handling of EUV reticles in such pods is enabled. This integrated solution for handling and storage is additionally being equipped with an integrated reticle back-side inspection capability.

  16. Plasmonic-multimode-interference-based logic circuit with simple phase adjustment

    NASA Astrophysics Data System (ADS)

    Ota, Masashi; Sumimura, Asahi; Fukuhara, Masashi; Ishii, Yuya; Fukuda, Mitsuo

    2016-04-01

    All-optical logic circuits using surface plasmon polaritons have a potential for high-speed information processing with high-density integration beyond the diffraction limit of propagating light. However, a number of logic gates that can be cascaded is limited by complicated signal phase adjustment. In this study, we demonstrate a half-adder operation with simple phase adjustment using plasmonic multimode interference (MMI) devices, composed of dielectric stripes on a metal film, which can be fabricated by a complementary metal-oxide semiconductor (MOS)-compatible process. Also, simultaneous operations of XOR and AND gates are substantiated experimentally by combining 1 × 1 MMI based phase adjusters and 2 × 2 MMI based intensity modulators. An experimental on-off ratio of at least 4.3 dB is confirmed using scanning near-field optical microscopy. The proposed structure will contribute to high-density plasmonic circuits, fabricated by complementary MOS-compatible process or printing techniques.

  17. An Innovative Compiler For Programming And Designing Real-Time Signal Processors

    NASA Astrophysics Data System (ADS)

    Petruschka, Orni; Torng, H. C.

    1986-04-01

    Real time signal processing tasks impose stringent requirements on computing systems. One approach to satisfying these demands is to employ intelligently interconnected multiple arithmetic units, such as multipliers, adders, logic units and others, to implement concurrent computations. Two problems emerge: 1) Programming: Programs with wide instruction words have to be developed to exercise the multiple arithmetic units fully and efficiently to meet the real-time processing loads; 2) Design: With a given set of real-time signal processing tasks, design procedures are needed to specify multiple arithmetic units and their interconnection schemes for the processor. This paper presents a compiler which provides a solution to the programming and design problems. The compiler that has been developed translates blocks of RISC-like instructions into programs of wide microinstructions; each of these microinstructions initiates many concurrently executable operations. In so doing, we seek to achieve the maximum utilization of execution resources and to complete processing tasks in minimum time. The compiler is based on an innovative "Dispatch Stack" concept, and has been applied to program Floating Point System(FPS) processors; the resulting program for computing inner-product and other signal processing tasks are as good as those obtained by laborious hand-compilation. We will then show that the compiler developed for programming can be used advantageously to design real-time signal processing systems with multiple arithmetic units.

  18. INDEP approach for leakage reduction in nanoscale CMOS circuits

    NASA Astrophysics Data System (ADS)

    Sharma, Vijay Kumar; Pattanaik, Manisha; Raj, Balwinder

    2015-02-01

    Complementary metal oxide semiconductor (CMOS) technology scaling for improving speed and functionality turns leakage power one of the major concerns for nanoscale circuits design. The minimization of leakage power is a rising challenge for the design of the existing and future nanoscale CMOS circuits. This paper presents a novel, input-dependent, transistor-level, low leakage and reliable INput DEPendent (INDEP) approach for nanoscale CMOS circuits. INDEP approach is based on Boolean logic calculations for the input signals of the extra inserted transistors within the logic circuit. The gate terminals of extra inserted transistors depend on the primary input combinations of the logic circuits. The appropriate selection of input gate voltages of INDEP transistors are reducing the leakage current efficiently along with rail to rail output voltage swing. The important characteristic of INDEP approach is that it works well in both active as well as standby modes of the circuits. This approach overcomes the limitations created by the prevalent current leakage reduction techniques. The simulation results indicate that INDEP approach mitigates 41.6% and 35% leakage power for 1-bit full adder and ISCAS-85 c17 benchmark circuit, respectively, at 32 nm bulk CMOS technology node.

  19. The dual cycle bridge detection of piezoresistive triaxial accelerometer based on MEMS technology

    NASA Astrophysics Data System (ADS)

    Juanting, Zhang; Changde, He; Hui, Zhang; Yuping, Li; Yongping, Zhang; Chunhui, Du; Wendong, Zhang

    2014-06-01

    A cycle bridge detection method, which uses a piezoresistive triaxial accelerometer, has been described innovatively. This method just uses eight resistors to form a cycle detection bridge, which can detect the signal of the three directions for real time. It breaks the law of the ordinary independent Wheatstone bridge detection method, which uses at least 12 resistors and each four resistors connected as a Wheatstone bridge to detect the output signal from a specific direction. In order to verify the feasibility of this method, the modeling and simulating of the sensor structure have been conducted by ANSYS, then the dual cycle bridge detection method and independent Wheatstone bridge detection method are compared, the result shows that the former method can improve the sensitivity of the sensor effectively. The sensitivity of the x, y-axis used in the former method is two times that of the sensor used in the latter method, and the sensitivity of the z-axis is four times. At the same time, it can also reduce the cross-axis coupling degree of the sensor used in the dual cycle bridge detection method. In addition, a signal amplifier circuit and adder circuit have been provided. Finally, the test result of the “eight-beams/mass” triaxial accelerometer, which is based on the dual cycle bridge detection method and the related circuits, have been provided. The results of the test and the theoretical analysis are consistent, on the whole.

  20. Quantum cellular automata

    NASA Astrophysics Data System (ADS)

    Porod, Wolfgang; Lent, Craig S.; Bernstein, Gary H.

    1994-06-01

    The Notre Dame group has developed a new paradigm for ultra-dense and ultra-fast information processing in nanoelectronic systems. These Quantum Cellular Automata (QCA's) are the first concrete proposal for a technology based on arrays of coupled quantum dots. The basic building block of these cellular arrays is the Notre Dame Logic Cell, as it has been called in the literature. The phenomenon of Coulomb exclusion, which is a synergistic interplay of quantum confinement and Coulomb interaction, leads to a bistable behavior of each cell which makes possible their use in large-scale cellular arrays. The physical interaction between neighboring cells has been exploited to implement logic functions. New functionality may be achieved in this fashion, and the Notre Dame group invented a versatile majority logic gate. In a series of papers, the feasibility of QCA wires, wire crossing, inverters, and Boolean logic gates was demonstrated. A major finding is that all logic functions may be integrated in a hierarchial fashion which allows the design of complicated QCA structures. The most complicated system which was simulated to date is a one-bit full adder consisting of some 200 cells. In addition to exploring these new concepts, efforts are under way to physically realize such structures both in semiconductor and metal systems. Extensive modeling work of semiconductor quantum dot structures has helped identify optimum design parameters for QCA experimental implementations.

  1. Improvement of defect mitigation with EUV actinic blank inspection prototype for 16 nm hp

    NASA Astrophysics Data System (ADS)

    Murachi, Tetsunori; Amano, Tsuyoshi; Suzuki, Tomohiro; Miyai, Hiroki

    2014-04-01

    A major challenge for extreme ultraviolet lithography (EUVL) is avoiding defects in the fabrication of multilayered (ML) mask blanks. Substrate defects and adders during ML coating are responsible for ML defects which causes changes on phase and amplitude of EUV light. ML defects must be identified by inspection prior to absorber patterning in order to reduce the effects of ML defects via covering them with patterns to permit the use of fewer ML defect blanks. Fiducial marks (FMs) on ML blanks can be used for mask alignment and to accurately and precisely determine the locations of ML defects. In this study, we fabricated an FM mask by resist exposure using an e-beam writer and etching. Then, we inspected FMs and ML defects with an EUV actinic full-field mask blank inspection tool developed by EIDEC-LaserTec (LT ABI). Next, we evaluated the ML defect location accuracy on the mask based on FMs of several line depths by deriving center position of FMs and defects with Lorentz, Gaussian fitting and center-of-mass calculation. Here, we explain the estimation of defect location accuracy using FMs and the LT ABI, and discuss the defect numbers which can be covered by absorber patterns. Fewer than 19 defects per blank should be required for EUV blanks to cover ML defects with patterns.

  2. CF6 jet engine performance deterioration results

    NASA Technical Reports Server (NTRS)

    Lewis, R. J.; Humerickhouse, C. E.; Paas, J. E.

    1978-01-01

    The use of the performance baseline from the flight planning manual as a reference to measure changes in cruise fuel flow rates was discussed. For the CF6-6D engine, the introduction of design changes for performance and durability reasons was seen to introduce an average increment relative to this baseline of 3.2% WFM increase at Nl, 2.5% Fn increase at Nl, 0.8% specific fuel consumption (SFC) increase at Fn, and 7 C EGT increase at Nl, while maintaining sufficient SFC margin of the delivered airplane. The effect of revenue service deterioration and performance restoration relative to the reference was shown to be an adder on top of these design effects. A schematic of typical CF6-6D performance through revenue service and airline maintenance is presented in terms of percent cruise SFC relative to an airline datum point (average level upon entering revenue service). The typical changes in SFC margin are shown for airline revenue service through for installations and refurbishments.

  3. Hardware Implementation of a Bilateral Subtraction Filter

    NASA Technical Reports Server (NTRS)

    Huertas, Andres; Watson, Robert; Villalpando, Carlos; Goldberg, Steven

    2009-01-01

    A bilateral subtraction filter has been implemented as a hardware module in the form of a field-programmable gate array (FPGA). In general, a bilateral subtraction filter is a key subsystem of a high-quality stereoscopic machine vision system that utilizes images that are large and/or dense. Bilateral subtraction filters have been implemented in software on general-purpose computers, but the processing speeds attainable in this way even on computers containing the fastest processors are insufficient for real-time applications. The present FPGA bilateral subtraction filter is intended to accelerate processing to real-time speed and to be a prototype of a link in a stereoscopic-machine- vision processing chain, now under development, that would process large and/or dense images in real time and would be implemented in an FPGA. In terms that are necessarily oversimplified for the sake of brevity, a bilateral subtraction filter is a smoothing, edge-preserving filter for suppressing low-frequency noise. The filter operation amounts to replacing the value for each pixel with a weighted average of the values of that pixel and the neighboring pixels in a predefined neighborhood or window (e.g., a 9 9 window). The filter weights depend partly on pixel values and partly on the window size. The present FPGA implementation of a bilateral subtraction filter utilizes a 9 9 window. This implementation was designed to take advantage of the ability to do many of the component computations in parallel pipelines to enable processing of image data at the rate at which they are generated. The filter can be considered to be divided into the following parts (see figure): a) An image pixel pipeline with a 9 9- pixel window generator, b) An array of processing elements; c) An adder tree; d) A smoothing-and-delaying unit; and e) A subtraction unit. After each 9 9 window is created, the affected pixel data are fed to the processing elements. Each processing element is fed the pixel value for

  4. Operateurs et engins de calcul en virgule flottante et leur application a la simulation en temps reel sur FPGA

    NASA Astrophysics Data System (ADS)

    Ould Bachir, Tarek

    The real-time simulation of electrical networks gained a vivid industrial interest during recent years, motivated by the substantial development cost reduction that such a prototyping approach can offer. Real-time simulation allows the progressive inclusion of real hardware during its development, allowing its testing under realistic conditions. However, CPU-based simulations suffer from certain limitations such as the difficulty to reach time-steps of a few microsecond, an important challenge brought by modern power converters. Hence, industrial practitioners adopted the FPGA as a platform of choice for the implementation of calculation engines dedicated to the rapid real-time simulation of electrical networks. The reconfigurable technology broke the 5 kHz switching frequency barrier that is characteristic of CPU-based simulations. Moreover, FPGA-based real-time simulation offers many advantages, including the reduced latency of the simulation loop that is obtained thanks to a direct access to sensors and actuators. The fixed-point format is paradigmatic to FPGA-based digital signal processing. However, the format imposes a time penalty in the development process since the designer has to asses the required precision for all model variables. This fact brought an import research effort on the use of the floating-point format for the simulation of electrical networks. One of the main challenges in the use of the floating-point format are the long latencies required by the elementary arithmetic operators, particularly when an adder is used as an accumulator, an important building bloc for the implementation of integration rules such as the trapezoidal method. Hence, single-cycle floating-point accumulation forms the core of this research work. Our results help building such operators as accumulators, multiply-accumulators (MACs), and dot-product (DP) operators. These operators play a key role in the implementation of the proposed calculation engines. Therefore, this

  5. Programmed DNA Self-Assembly and Logic Circuits

    NASA Astrophysics Data System (ADS)

    Li, Wei

    DNA is a unique, highly programmable and addressable biomolecule. Due to its reliable and predictable base recognition behavior, uniform structural properties, and extraordinary stability, DNA molecules are desirable substrates for biological computation and nanotechnology. The field of DNA computation has gained considerable attention due to the possibility of exploiting the massive parallelism that is inherent in natural systems to solve computational problems. This dissertation focuses on building novel types of computational DNA systems based on both DNA reaction networks and DNA nanotechnology. A series of related research projects are presented here. First, a novel, three-input majority logic gate based on DNA strand displacement reactions was constructed. Here, the three inputs in the majority gate have equal priority, and the output will be true if any two of the inputs are true. We subsequently designed and realized a complex, 5-input majority logic gate. By controlling two of the five inputs, the complex gate is capable of realizing every combination of OR and AND gates of the other 3 inputs. Next, we constructed a half adder, which is a basic arithmetic unit, from DNA strand operated XOR and AND gates. The aim of these two projects was to develop novel types of DNA logic gates to enrich the DNA computation toolbox, and to examine plausible ways to implement large scale DNA logic circuits. The third project utilized a two dimensional DNA origami frame shaped structure with a hollow interior where DNA hybridization seeds were selectively positioned to control the assembly of small DNA tile building blocks. The small DNA tiles were directed to fill the hollow interior of the DNA origami frame, guided through sticky end interactions at prescribed positions. This research shed light on the fundamental behavior of DNA based self-assembling systems, and provided the information necessary to build programmed nanodisplays based on the self-assembly of DNA.

  6. NASA Tech Briefs, January 2003

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Topics covered include: Optoelectronic Tool Adds Scale Marks to Photographic Images; Compact Interconnection Networks Based on Quantum Dots; Laterally Coupled Quantum-Dot Distributed-Feedback Lasers; Bit-Serial Adder Based on Quantum Dots; Stabilized Fiber-Optic Distribution of Reference Frequency; Delay/Doppler-Mapping GPS-Reflection Remote-Sensing System; Ladar System Identifies Obstacles Partly Hidden by Grass; Survivable Failure Data Recorders for Spacecraft; Fiber-Optic Ammonia Sensors; Silicon Membrane Mirrors with Electrostatic Shape Actuators; Nanoscale Hot-Wire Probes for Boundary-Layer Flows; Theodolite with CCD Camera for Safe Measurement of Laser-Beam Pointing; Efficient Coupling of Lasers to Telescopes with Obscuration; Aligning Three Off-Axis Mirrors with Help of a DOE; Calibrating Laser Gas Measurements by Use of Natural CO2; Laser Ranging Simulation Program; Micro-Ball-Lens Optical Switch Driven by SMA Actuator; Evaluation of Charge Storage and Decay in Spacecraft Insulators; Alkaline Capacitors Based on Nitride Nanoparticles; Low-EC-Content Electrolytes for Low-Temperature Li-Ion Cells; Software for a GPS-Reflection Remote-Sensing System; Software for Building Models of 3D Objects via the Internet; "Virtual Cockpit Window" for a Windowless Aerospacecraft; CLARAty Functional-Layer Software; Java Library for Input and Output of Image Data and Metadata; Software for Estimating Costs of Testing Rocket Engines; Energy-Absorbing, Lightweight Wheels; Viscoelastic Vibration Dampers for Turbomachine Blades; Soft Landing of Spacecraft on Energy-Absorbing Self-Deployable Cushions; Pneumatically Actuated Miniature Peristaltic Vacuum Pumps; Miniature Gas-Turbine Power Generator; Pressure-Sensor Assembly Technique; Wafer-Level Membrane-Transfer Process for Fabricating MEMS; A Reactive-Ion Etch for Patterning Piezoelectric Thin Film; Wavelet-Based Real-Time Diagnosis of Complex Systems; Quantum Search in Hilbert Space; Analytic Method for Computing Instrument

  7. Spatial Structure in the Infrared Spectra of Three Evolved Stars

    NASA Astrophysics Data System (ADS)

    Sloan, G. C.; Tandy, P. C.; Pirger, B. E.; Hodge, T. M.

    1993-05-01

    We have spatially resolved three evolved sources using GLADYS, a long-slit 10 microns spectrometer, at the Wyoming Infrared Observatory. These observations, made in 1993 March, were the first for GLADYS after a complete replacement of the detector drive electronics, ADCs, and hardware co-adder. We studied each source in a north/south and an east/west slit orientation. For each set of observations, we fit a gaussian to the spatial profile at each wavelength to create a spatiogram, or plot of the width of the spectrum as a function of wavelength. In both slit orientations, the spatiogram of alpha Orionis is widest at 10 microns, where the contribution from the silicate dust in the circumstellar shell is strongest. The FWHM at 10 microns is 2.0 arcsec, while our point-source comparison has a FWHM of 1.6 arcsec. These results are very similar to those presented for a N/S slit by Grasdalen, Sloan, and LeVan (1992, ApJ, 384, L25). IRC+10216 is also resolved in both slit orientations, having a FWHM of 1.9 arcsec at 11 microns, compared with 1.5 arcsec for a point source. No spectral structure is apparent in the spatiograms, indicating that there is little change in the spectral character of the emission across the source. AFGL 2688 (the Cygnus Egg) is clearly resolved in the N/S slit orientation, where its FWHM at 11 microns is 2.2 arcsec, but its spatiogram in the E/W slit orientation is barely distinguishable from that of a point source.

  8. COBRA accelerator for Sandia ICF diode research at Cornell University

    SciTech Connect

    Smith, D.L.; Ingwersen, P.; Bennett, L.F.; Boyes, J.D.; Anderson, D.E.; Greenly, J.B.; Sudan, R.N.

    1995-05-01

    The new COBRA accelerator is being built in stages at the Laboratory of Plasma Studies in Cornell University where its applications will include extraction diode and ion beam research in support of the light ion inertial confinement fusion (ICF) program at Sandia National Laboratories. The 4- to 5-MV, 125- to 250-kA accelerator is based on a four-cavity inductive voltage adder (IVA) design. It is a combination of new ferromagnetically-isolated cavities and self magnetically insulated transmission line (MITL) hardware and components from existing Sandia and Cornell facilities: Marx generator capacitors, hardware, and power supply from the DEMON facility; water pulse forming lines (PFL) and gas switch from the Subsystem Test Facility (STF); a HERMES-III intermediate store capacitor (ISC); and a modified ion diode from Cornell`s LION. The present accelerator consists of a single modified cavity similar to those of the Sandia SABRE accelerator and will be used to establish an operating system for the first stage initial lower voltage testing. Four new cavities will be fabricated and delivered in the first half of FY96 to complete the COBRA accelerator. COBRA is unique in the sense that each cavity is driven by a single pulse forming line, and the IVA output polarity may be reversed by rotating the cavities 180{degrees} about their vertical axis. The site preparations, tank construction, and diode design and development are taking place at Cornell with growing enthusiasm as this machine becomes a reality. Preliminary results with the single cavity and short positive inner cylinder MITL configuration will soon be available.

  9. Incorporating global warming risks in power sector planning: A case study of the New England region. Volume 1

    SciTech Connect

    Krause, F.; Busch, J.; Koomey, J.

    1992-11-01

    Growing international concern over the threat of global climate change has led to proposals to buy insurance against this threat by reducing emissions of carbon (short for carbon dioxide) and other greenhouse gases below current levels. Concern over these and other, non-climatic environmental effects of electricity generation has led a number of states to adopt or explore new mechanisms for incorporating environmental externalities in utility resource planning. For example, the New York and Massachusetts utility commissions have adopted monetized surcharges (or adders) to induce emission reductions of federally regulated air pollutants (notably, SO{sub 2}, NO{sub x}, and particulates) beyond federally mandated levels. These regulations also include preliminary estimates of the cost of reducing carbon emissions, for which no federal regulations exist at this time. Within New England, regulators and utilities have also held several workshops and meetings to discuss alternative methods of incorporating externalities as well as the feasibility of regional approaches. This study examines the potential for reduced carbon emissions in the New England power sector as well as the cost and rate impacts of two policy approaches: environmental externality surcharges and a target- based approach. We analyze the following questions: Does New England have sufficient low-carbon resources to achieve significant reductions (10% to 20% below current levels) in fossil carbon emissions in its utility sector? What reductions could be achieved at a maximum? What is the expected cost of carbon reductions as a function of the reduction goal? How would carbon reduction strategies affect electricity rates? How effective are environmental externality cost surcharges as an instrument in bringing about carbon reductions? To what extent could the minimization of total electricity costs alone result in carbon reductions relative to conventional resource plans?

  10. A 16X16 Discrete Cosine Transform Chip

    NASA Astrophysics Data System (ADS)

    Sun, M. T.; Chen, T. C.; Gottlieb, A.; Wu, L.; Liou, M. L.

    1987-10-01

    Among various transform coding techniques for image compression the Discrete Cosine Transform (DCT) is considered to be the most effective method and has been widely used in the laboratory as well as in the market, place. DCT is computationally intensive. For video application at 14.3 MHz sample rate, a direct implementation of a 16x16 DCT requires a throughput, rate of approximately half a billion multiplications per second. In order to reduce the cost of hardware implementation, a single chip DCT implementation is highly desirable. In this paper, the implementation of a 16x16 DCT chip using a concurrent architecture will be presented. The chip is designed for real-time processing of 14.3 MHz sampled video data. It uses row-column decomposition to implement the two-dimensional transform. Distributed arithmetic combined with hit-serial and hit-parallel structures is used to implement the required vector inner products concurrently. Several schemes are utilized to reduce the size of required memory. The resultant circuit only uses memory, shift registers, and adders. No multipliers are required. It achieves high speed performance with a very regular and efficient integrated circuit realization. The chip accepts 0-bit input and produces 14-bit DCT coefficients. 12 bits are maintained after the first one-dimensional transform. The circuit has been laid out using a 2-μm CMOS technology with a symbolic design tool MULGA. The core contains approximately 73,000 transistors in an area of 7.2 x 7.0

  11. Recovery of soil physical properties and microbiology in foresty drained peatlands from the impact of forest machinery

    NASA Astrophysics Data System (ADS)

    Lepilin, Dmitrii; Kimura, Bryn; Uusitalo, Jori; Laiho, Raija; Fritze, Hannu; Lauren, Ari; Tuittila, Eeva-Stiina

    2016-04-01

    Forestry-drained peatlands occupy approximately 5.7 million ha and represent almost one fourth of the total forest surface in Finland. They are subjected to the same silvicultural harvesting operations as upland forests. However, although the potential of timber harvesting to cause detrimental effects on soil is well documented in upland forests, the knowledge on environmental impact of harvesting machinery on peat soils is still lacking. To assess the impact of harvesting machines on peat physical properties and biology we collected soil samples from six peatland forests that were harvested by commonly employed Harvester and Forwarder. Samples were taken from trails formed by harvesting machinery (treatment plots) and outside of trails (control plots unaffected by machinery traffic) to a depth of 15 cm. To adders the recovery of soil properties after disturbance we sampled sites that form a chronosequence in respect to time since harvesting: 1 month (class I), 3-4 years (class II) and 14-15 years (class III). The physical and microbiological properties of soil samples were analyzed in laboratory. Harvesting operations with heavy machinery appeared to significantly increase the bulk density of peat in the machines' trails at recently harvested sites in comparison to control plots. Following change in bulk density there was change of pore size distribution with decreasing macrospores quantity. This led to slight decrease of total porosity and decrease of air filled porosity. Water retention capacity increased with increasing bulk density. CO2 evolution increased in the trails of class I site with where dissolved organic carbon concurrently decreased. While there was not impact of harvesting on microbial biomass or carbon, PLFA analysis indicated that machinery traffic caused a shift in microbial community structure. Results of class II and class III sites showed a recovery of physical properties within 16 years: treatment plots and control plots started to resemble

  12. An example of a digital synthesis approach to DSP design: The AGS transverse damper

    SciTech Connect

    Brown, K.A.; Smith, G.; Wong, V.

    1997-07-01

    Using Verilog HDL and Synopsys, the digital signal processing of the AGS Transverse Damper was designed and fitted to an Altera Flex l0k FPGA. Using a control point specification style in the high level description greatly simplified the design by placing the burden of specifying the controller on the digital synthesizer. The basic design and low level simulation are presented as well as the design methodology. The purpose of the AGS Transverse Damper is to control instabilities and injection errors that may arise in high intensity proton beams being accelerated in the AGS. The system block diagram for the DSP is shown in Figure 1. The inputs to the system come from a normalization unit. This normalization unit takes two signals as input, a sum of beam position signal plates, and a difference from the plates. The output of the normalization unit is the difference divided by the sum. This Quotient is sent to the first ALU (as Qin[11..0]). Taking differences between position measurements the system acts as a notch filter. The Second ALU computes a running sum of the output of the first ALU. This then acts to remove any offsets in the Quotient (and thus this part acts as a high pass filter - removing any baseline components to the signal). The depth of the first FIFO (between adder and subtract units) basically determines the low pass behaviour. The multiplier serves the purpose of overall loop gain for the system (the complete system is a real-time feedback system). The FIFO on the output is used to provide the correct amount of delay for the system.

  13. Method and apparatus for enhancing microchannel plate data

    DOEpatents

    Thoe, Robert S.

    1987-01-01

    A method and apparatus for determining centroid channel locations is disclosed for use in a system activated by one or more multichannel plates (16,18) and including a linear diode array (24) providing channels of information 1, 2, . . . , n, . . . , N containing signal amplitudes A.sub.n. A source of analog A.sub.n signals (40), and a source of digital clock signals n (48), are provided. Non-zero A.sub.n values are detected in a discriminator (42). A digital signal representing p, the value of n immediately preceding that whereat A.sub.n takes its first non-zero value, is generated in a scaler (50). The analog A.sub.n signals are converted to digital in an analog to digital converter (44). The digital A.sub.n signals are added to produce a digital .SIGMA.A.sub.n signal in a full adder (46). Digital 1, 2, . . . , m signals representing the number of non-zero A.sub.n are produced by a discriminator pulse counter (52). Digital signals representing 1 A.sub.p+ 1, 2 A.sub.p+2, . . . , m A.sub.p+m are produced by pairwise multiplication in multiplier (54). These signals are added in multiplier summer (56) to produce a digital .SIGMA.nA.sub.n -p.SIGMA.A.sub.n signal. This signal is divided by the digital .SIGMA.A.sub.n signal in divider (58) to provide a digital (.SIGMA.nA.sub.n /.SIGMA.A.sub.n) -p signal. Finally, this last signal is added to the digital p signal in an offset summer (60) to provide .SIGMA.nA.sub.n /.SIGMA.A.sub.n, the centroid channel locations.

  14. Hybridizing triboelectrification and electromagnetic induction effects for high-efficient mechanical energy harvesting.

    PubMed

    Hu, Youfan; Yang, Jin; Niu, Simiao; Wu, Wenzhuo; Wang, Zhong Lin

    2014-07-22

    The recently introduced triboelectric nanogenerator (TENG) and the traditional electromagnetic induction generator (EMIG) are coherently integrated in one structure for energy harvesting and vibration sensing/isolation. The suspended structure is based on two oppositely oriented magnets that are enclosed by hollow cubes surrounded with coils, which oscillates in response to external disturbance and harvests mechanical energy simultaneously from triboelectrification and electromagnetic induction. It extends the previous definition of hybrid cell to harvest the same type of energy with multiple approaches. Both the sliding-mode TENG and contact-mode TENG can be achieved in the same structure. In order to make the TENG and EMIG work together, transformers are used to match the output impedance between these two power sources with very different characteristics. The maximum output power of 7.7 and 1.9 mW on the same load of 5 kΩ was obtained for the TENG and EMIG, respectively, after impedance matching. Benefiting from the rational design, the output signal from the TENG and the EMIG are in phase. They can be added up directly to get an output voltage of 4.6 V and an output current of 2.2 mA in parallel connection. A power management circuit was connected to the hybrid cell, and a regulated voltage of 3.3 V with constant current was achieved. For the first time, a logic operation was carried out on a half-adder circuit by using the hybrid cell working as both the power source and the input digit signals. We also demonstrated that the hybrid cell can serve as a vibration isolator. Further applications as vibration dampers, triggers, and sensors are all promising. PMID:24924185

  15. Ultrafast all-optical arithmetic logic based on hydrogenated amorphous silicon microring resonators

    NASA Astrophysics Data System (ADS)

    Gostimirovic, Dusan; Ye, Winnie N.

    2016-03-01

    For decades, the semiconductor industry has been steadily shrinking transistor sizes to fit more performance into a single silicon-based integrated chip. This technology has become the driving force for advances in education, transportation, and health, among others. However, transistor sizes are quickly approaching their physical limits (channel lengths are now only a few silicon atoms in length), and Moore's law will likely soon be brought to a stand-still despite many unique attempts to keep it going (FinFETs, high-k dielectrics, etc.). This technology must then be pushed further by exploring (almost) entirely new methodologies. Given the explosive growth of optical-based long-haul telecommunications, we look to apply the use of high-speed optics as a substitute to the digital model; where slow, lossy, and noisy metal interconnections act as a major bottleneck to performance. We combine the (nonlinear) optical Kerr effect with a single add-drop microring resonator to perform the fundamental AND-XOR logical operations of a half adder, by all-optical means. This process is also applied to subtraction, higher-order addition, and the realization of an all-optical arithmetic logic unit (ALU). The rings use hydrogenated amorphous silicon as a material with superior nonlinear properties to crystalline silicon, while still maintaining CMOS-compatibility and the many benefits that come with it (low cost, ease of fabrication, etc.). Our method allows for multi-gigabit-per-second data rates while maintaining simplicity and spatial minimalism in design for high-capacity manufacturing potential.

  16. Reconfigurable Fault Tolerance for FPGAs

    NASA Technical Reports Server (NTRS)

    Shuler, Robert, Jr.

    2010-01-01

    The invention allows a field-programmable gate array (FPGA) or similar device to be efficiently reconfigured in whole or in part to provide higher capacity, non-redundant operation. The redundant device consists of functional units such as adders or multipliers, configuration memory for the functional units, a programmable routing method, configuration memory for the routing method, and various other features such as block RAM, I/O (random access memory, input/output) capability, dedicated carry logic, etc. The redundant device has three identical sets of functional units and routing resources and majority voters that correct errors. The configuration memory may or may not be redundant, depending on need. For example, SRAM-based FPGAs will need some type of radiation-tolerant configuration memory, or they will need triple-redundant configuration memory. Flash or anti-fuse devices will generally not need redundant configuration memory. Some means of loading and verifying the configuration memory is also required. These are all components of the pre-existing redundant FPGA. This innovation modifies the voter to accept a MODE input, which specifies whether ordinary voting is to occur, or if redundancy is to be split. Generally, additional routing resources will also be required to pass data between sections of the device created by splitting the redundancy. In redundancy mode, the voters produce an output corresponding to the two inputs that agree, in the usual fashion. In the split mode, the voters select just one input and convey this to the output, ignoring the other inputs. In a dual-redundant system (as opposed to triple-redundant), instead of a voter, there is some means to latch or gate a state update only when both inputs agree. In this case, the invention would require modification of the latch or gate so that it would operate normally in redundant mode, and would separately latch or gate the inputs in non-redundant mode.

  17. Method and apparatus for enhancing microchannel plate data

    DOEpatents

    Thoe, R.S.

    1983-10-24

    A method and apparatus for determining centroid channel locations are disclosed for use in a system activated by one or more multichannel plates and including a linear diode array providing channels of information 1, 2, ...,n, ..., N containing signal amplitudes A/sub n/. A source of analog A/sub n/ signals, and a source of digital clock signals n, are provided. Non-zero A/sub n/ values are detected in a discriminator. A digital signal representing p, the value of n immediately preceding that whereat A/sub n/ takes its first non-zero value, is generated in a scaler. The analog A/sub n/ signals are converted to digital in an analog to digital converter. The digital A/sub n/ signals are added to produce a digital ..sigma..A/sub n/ signal in a full adder. Digital 1, 2, ..., m signals representing the number of non-zero A/sub n/ are produced by a discriminator pulse counter. Digital signals representing 1 A/sub p+1/, 2 A/sub p+2/, ..., m A/sub p+m/ are produced by pairwise multiplication in multiplier. These signal are added in multiplier summer to produce a digital ..sigma..nA/sub n/ - p..sigma..A/sub n/ signal. This signal is divided by the digital ..sigma..A/sub n/ signal in divider to provide a digital (..sigma..nA/sub n//..sigma..A/sub n/) -p signal. Finally, this last signal is added to the digital p signal in an offset summer to provide ..sigma..nA/sub n//..sigma..A/sub n/, the centroid channel locations.

  18. Nanoimprint system development and status for high-volume semiconductor manufacturing

    NASA Astrophysics Data System (ADS)

    Takashima, Tsuneo; Takabayashi, Yukio; Nishimura, Naosuke; Emoto, Keiji; Matsumoto, Takahiro; Hayashi, Tatsuya; Kimura, Atsushi; Choi, Jin; Schumaker, Philip

    2016-03-01

    Imprint lithography has been shown to be an effective technique for replication of nano-scale features. Jet and Flash* Imprint Lithography (J-FIL*) involves the field-by-field deposition and exposure of a low viscosity resist deposited by jetting technology onto the substrate. The patterned mask is lowered into the fluid which then quickly flows into the relief patterns in the mask by capillary action. Following this filling step, the resist is crosslinked under UV radiation, and then the mask is removed, leaving a patterned resist on the substrate. Criteria specific to any lithographic process for the semiconductor industry include overlay, throughput and defectivity. The purpose of this paper is to describe the technology advancements made overlay, throughput and defectivity and to introduce the FPA-1200NZ2C cluster system designed for high volume manufacturing of semiconductor devices. in the reduction of particle adders in an imprint tool and introduce the new mask replication tool that will enable the fabrication of replica masks with added residual image placement errors suitable for memory devices with half pitches smaller than 15nm. Overlay results better than 5nm 3sigma have been demonstrated. To further enhance overlay, wafer chucks with improved flatness have been implemented to reduce distortion at the wafer edge. To address higher order corrections, a two part solution is discussed. An array of piezo actuators can be applied to enable linear corrections. Additional reductions in distortion can then be addressed by the local heating of a wafer field. The NZ2C cluster platform for high volume manufacturing is also discussed. System development continues this year with a target for introduction later in 2016. The first application is likely to be NAND Flash memory, and eventual use for DRAM and logic devices as both overlay and defectivity improve.

  19. Framework for Integrating Science Data Processing Algorithms Into Process Control Systems

    NASA Technical Reports Server (NTRS)

    Mattmann, Chris A.; Crichton, Daniel J.; Chang, Albert Y.; Foster, Brian M.; Freeborn, Dana J.; Woollard, David M.; Ramirez, Paul M.

    2011-01-01

    A software framework called PCS Task Wrapper is responsible for standardizing the setup, process initiation, execution, and file management tasks surrounding the execution of science data algorithms, which are referred to by NASA as Product Generation Executives (PGEs). PGEs codify a scientific algorithm, some step in the overall scientific process involved in a mission science workflow. The PCS Task Wrapper provides a stable operating environment to the underlying PGE during its execution lifecycle. If the PGE requires a file, or metadata regarding the file, the PCS Task Wrapper is responsible for delivering that information to the PGE in a manner that meets its requirements. If the PGE requires knowledge of upstream or downstream PGEs in a sequence of executions, that information is also made available. Finally, if information regarding disk space, or node information such as CPU availability, etc., is required, the PCS Task Wrapper provides this information to the underlying PGE. After this information is collected, the PGE is executed, and its output Product file and Metadata generation is managed via the PCS Task Wrapper framework. The innovation is responsible for marshalling output Products and Metadata back to a PCS File Management component for use in downstream data processing and pedigree. In support of this, the PCS Task Wrapper leverages the PCS Crawler Framework to ingest (during pipeline processing) the output Product files and Metadata produced by the PGE. The architectural components of the PCS Task Wrapper framework include PGE Task Instance, PGE Config File Builder, Config File Property Adder, Science PGE Config File Writer, and PCS Met file Writer. This innovative framework is really the unifying bridge between the execution of a step in the overall processing pipeline, and the available PCS component services as well as the information that they collectively manage.

  20. Cygnus Water Switch Jitter

    SciTech Connect

    Charles V. Mitton, George D. Corrow, Mark D. Hansen, David J. Henderson, et al.

    2008-03-01

    The Cygnus Dual Beam Radiographic Facility consists of two identical radiographic sources - Cygnus 1 and Cygnus 2. Each source has the following x-ray output: 1-mm diameter spot size, 4 rad at 1 m, 50-ns Full Width Half Max. The diode pulse has the following electrical specifications: 2.25 MV, 60 kA, 60 ns. This Radiographic Facility is located in an underground tunnel test area at the Nevada Test Site (NTS). The sources were developed to produce high-resolution images on subcritical tests which are performed at NTS. Subcritical tests are single-shot, high-value events. For this application, it is desirable to maintain a high level of reproducibility in source output. The major components of the Cygnus machines are: Marx generator, water-filled pulse–forming line (PFL), water-filled coaxial transmission line, three-cell inductive voltage adder, and rod-pinch diode. A primary source of fluctuation in Cygnus shot-to-shot performance is jitter in breakdown of the main PFL switch, which is a “self-break” switch. The PFL switch breakdown time determines the peak PFL charging voltage, which ultimately affects the diode pulse. Therefore, PFL switch jitter contributes to shot-to-shot variation in source endpoint energy and dose. In this paper we will present PFL switch jitter analysis for both Cygnus machines and give the correlation with diode performance. For this analysis the PFL switch on each machine was maintained at a single gap setting which has been used for the majority of shots at NTS. In addition to this analysis, PFL switch performance for different switch gap settings taken recently will be examined. Lastly, implications of source jitter for radiographic diagnosis of subcritical shots will be discussed.

  1. Use of a radial self-field diode geometry for intense pulsed ion beam generation at 6 MeV on Hermes III

    SciTech Connect

    Renk, T. J. Harper-Slaboszewicz, V.; Mikkelson, K. A.; Ginn, W. C.; Ottinger, P. F.; Schumer, J. W.

    2014-12-15

    We investigate the generation of intense pulsed focused ion beams at the 6 MeV level using an inductive voltage adder (IVA) pulsed-power generator, which employs a magnetically insulated transmission line (MITL). Such IVA machines typical run at an impedance of few tens of Ohms. Previous successful intense ion beam generation experiments have often featured an “axial” pinch-reflex ion diode (i.e., with an axial anode-cathode gap) and operated on a conventional Marx generator/water line driver with an impedance of a few Ohms and no need for an MITL. The goals of these experiments are to develop a pinch-reflex ion diode geometry that has an impedance to efficiently match to an IVA, produces a reasonably high ion current fraction, captures the vacuum electron current flowing forward in the MITL, and focuses the resulting ion beam to small spot size. A new “radial” pinch-reflex ion diode (i.e., with a radial anode-cathode gap) is found to best demonstrate these properties. Operation in both positive and negative polarities was undertaken, although the negative polarity experiments are emphasized. Particle-in-cell (PIC) simulations are consistent with experimental results indicating that, for diode impedances less than the self-limited impedance of the MITL, almost all of the forward-going IVA vacuum electron flow current is incorporated into the diode current. PIC results also provide understanding of the diode-impedance and ion-focusing properties of the diode. In addition, a substantial high-energy ion population is also identified propagating in the “reverse” direction, i.e., from the back side of the anode foil in the electron beam dump.

  2. Cell-size control and homeostasis in bacteria.

    PubMed

    Taheri-Araghi, Sattar; Bradde, Serena; Sauls, John T; Hill, Norbert S; Levin, Petra Anne; Paulsson, Johan; Vergassola, Massimo; Jun, Suckjoon

    2015-02-01

    How cells control their size and maintain size homeostasis is a fundamental open question. Cell-size homeostasis has been discussed in the context of two major paradigms: "sizer," in which the cell actively monitors its size and triggers the cell cycle once it reaches a critical size, and "timer," in which the cell attempts to grow for a specific amount of time before division. These paradigms, in conjunction with the "growth law" [1] and the quantitative bacterial cell-cycle model [2], inspired numerous theoretical models [3-9] and experimental investigations, from growth [10, 11] to cell cycle and size control [12-15]. However, experimental evidence involved difficult-to-verify assumptions or population-averaged data, which allowed different interpretations [1-5, 16-20] or limited conclusions [4-9]. In particular, population-averaged data and correlations are inconclusive as the averaging process masks causal effects at the cellular level. In this work, we extended a microfluidic "mother machine" [21] and monitored hundreds of thousands of Gram-negative Escherichia coli and Gram-positive Bacillus subtilis cells under a wide range of steady-state growth conditions. Our combined experimental results and quantitative analysis demonstrate that cells add a constant volume each generation, irrespective of their newborn sizes, conclusively supporting the so-called constant Δ model. This model was introduced for E. coli [6, 7] and recently revisited [9], but experimental evidence was limited to correlations. This "adder" principle quantitatively explains experimental data at both the population and single-cell levels, including the origin and the hierarchy of variability in the size-control mechanisms and how cells maintain size homeostasis. PMID:25544609

  3. Allowance trading under the Clean Air Act: Who should regulate, and when?

    SciTech Connect

    Lock, R.

    1993-07-01

    The goal of this paper is to explore how compliance with the Clean Air Act Amendments of 1990 (CAAA), especially Title IV and emission trading under it, will affect the current relationship between state and federal regulation. It is difficult, with the limited experience we have had under Title IV, to be definitive about or to be a very strong advocate of too many policy positions. What may be most helpful at this point is to identify where the difficult issues in state/federal relations might arise; and then to explore ways in which tensions might be either avoided or resolved. One anticipated conclusion is that a traditional regulatory mindset could be very destructive if applied to this new area of oversight without due sensitivity to what Congress is trying to achieve in Title IV. That concern pervaded the early legislative debates; and it persists today. Title IV presents some unique challenges to state regulators and will require some creative solutions and fresh thinking if the goals of Congress are to be realized and the full benefits that allowance trading can offer are to be reaped by electricity consumers. In the ultimate analysis, Title IV amounts to a massive internalization of the external costs imposed on society by acid rain deposition. (This places in serious question the notion of additional externality {open_quotes}adders{close_quotes} for sulfur dioxide (SO{sub 2}) and nitrous oxide (NO{sub x}) at the state level for utility supply planning purposes.) The whole point of Title IV is to give those directly charged with compliance, namely power producers, the maximum flexibility to pursue least-cost compliance solutions. Perhaps the biggest single factor in how well they do this will be how state regulators respond to their compliance and allowance trading initiatives.

  4. 8-channel acquisition system for time-correlated single-photon counting

    NASA Astrophysics Data System (ADS)

    Antonioli, S.; Miari, L.; Cuccato, A.; Crotti, M.; Rech, I.; Ghioni, M.

    2013-06-01

    Nowadays, an increasing number of applications require high-performance analytical instruments capable to detect the temporal trend of weak and fast light signals with picosecond time resolution. The Time-Correlated Single-Photon Counting (TCSPC) technique is currently one of the preferable solutions when such critical optical signals have to be analyzed and it is fully exploited in biomedical and chemical research fields, as well as in security and space applications. Recent progress in the field of single-photon detector arrays is pushing research towards the development of high performance multichannel TCSPC systems, opening the way to modern time-resolved multi-dimensional optical analysis. In this paper we describe a new 8-channel high-performance TCSPC acquisition system, designed to be compact and versatile, to be used in modern TCSPC measurement setups. We designed a novel integrated circuit including a multichannel Time-to-Amplitude Converter with variable full-scale range, a D/A converter, and a parallel adder stage. The latter is used to adapt each converter output to the input dynamic range of a commercial 8-channel Analog-to-Digital Converter, while the integrated DAC implements the dithering technique with as small as possible area occupation. The use of this monolithic circuit made the design of a scalable system of very small dimensions (95 × 40 mm) and low power consumption (6 W) possible. Data acquired from the TCSPC measurement are digitally processed and stored inside an FPGA (Field-Programmable Gate Array), while a USB transceiver allows real-time transmission of up to eight TCSPC histograms to a remote PC. Eventually, the experimental results demonstrate that the acquisition system performs TCSPC measurements with high conversion rate (up to 5 MHz/channel), extremely low differential nonlinearity (<0.04 peak-to-peak of the time bin width), high time resolution (down to 20 ps Full-Width Half-Maximum), and very low crosstalk between channels.

  5. Cygnus PFL Switch Jitter

    SciTech Connect

    C. Mitton, G. Corrow, M. Hansen, D. Henderson, et al.

    2007-07-21

    The Cygnus Dual Beam Radiographic Facility consists of two identical radiographic sources: Cygnus 1 and Cygnus 2. Each source has the following X-ray output: 1-mm diameter spot size, 4 rads at 1 m, 50-ns full-widthhalf-maximum. The diode pulse has the following electrical specifications: 2.25 MV, 60 kA, 60 ns. This Radiographic Facility is located in an underground tunnel test area at the Nevada Test Site (NTS). The sources were developed to produce high-resolution images on subcritical tests performed at NTS. Subcritical tests are single-shot, high-value events. For this application, it is desirable to maintain a high level of reproducibility in source output. The major components of the Cygnus machines are Marx generator, water-filled pulse forming line (PFL), water-filled coaxial transmission line, threecell inductive voltage adder, and rod-pinch diode. A primary source of fluctuation in Cygnus shot-to-shot performance may be jitter in breakdown of the main PFL switch, which is a “self-break” switch. The PFL switch breakdown time determines the peak PFL charging voltage, which ultimately affects the source X-ray spectrum and dose. Therefore, PFL switch jitter may contribute to shot-to-shot variation in these parameters, which are crucial to radiographic quality. In this paper we will present PFL switch jitter analysis for both Cygnus machines and present the correlation with dose. For this analysis, the PFL switch on each machine was maintained at a single gap setting, which has been used for the majority of shots at NTS. In addition the PFL switch performance for one larger switch gap setting will be examined.

  6. COBRA accelerator for Sandia ICF diode research at Cornell University

    NASA Astrophysics Data System (ADS)

    Smith, David L.; Ingwersen, Pete; Bennett, Lawrence F.; Boyes, John D.; Anderson, David E.; Greenly, John B.; Sudan, Ravi N.

    The new COBRA accelerator is being built in stages at the Laboratory of Plasma Studies in Cornell University where its applications will include extraction diode and ion beam research in support of the light ion inertial confinement fusion (ICF) program at Sandia National Laboratories. The 4- to 5-MV, 125- to 250-kA accelerator is based on a four-cavity inductive voltage adder (IVA) design. It is a combination of new ferromagnetically-isolated cavities and self magnetically insulated transmission line (MITL) hardware and components from existing Sandia and Cornell facilities: Marx generator capacitors, hardware, and power supply from the DEMON facility; water pulse forming lines (PFL) and gas switch from the Subsystem Test Facility (STF); a HERMES-3 intermediate store capacitor (ISC); and a modified ion diode from Cornell's LION. The present accelerator consists of a single modified cavity similar to those of the Sandia SABRE accelerator and will be used to establish an operating system for the first stage initial lower voltage testing. Four new cavities will be fabricated and delivered in the first half of FY96 to complete the COBRA accelerator. COBRA is unique in the sense that each cavity is driven by a single pulse forming line, and the IVA output polarity may be reversed by rotating the cavities 180(degrees) about their vertical axis. The site preparations, tank construction, and diode design and development are taking place at Cornell with growing enthusiasm as this machine becomes a reality. Preliminary results with the single cavity and short positive inner cylinder MITL configuration will soon be available.

  7. Use of a radial self-field diode geometry for intense pulsed ion beam generation at 6 MeV on Hermes III

    NASA Astrophysics Data System (ADS)

    Renk, T. J.; Harper-Slaboszewicz, V.; Mikkelson, K. A.; Ginn, W. C.; Ottinger, P. F.; Schumer, J. W.

    2014-12-01

    We investigate the generation of intense pulsed focused ion beams at the 6 MeV level using an inductive voltage adder (IVA) pulsed-power generator, which employs a magnetically insulated transmission line (MITL). Such IVA machines typical run at an impedance of few tens of Ohms. Previous successful intense ion beam generation experiments have often featured an "axial" pinch-reflex ion diode (i.e., with an axial anode-cathode gap) and operated on a conventional Marx generator/water line driver with an impedance of a few Ohms and no need for an MITL. The goals of these experiments are to develop a pinch-reflex ion diode geometry that has an impedance to efficiently match to an IVA, produces a reasonably high ion current fraction, captures the vacuum electron current flowing forward in the MITL, and focuses the resulting ion beam to small spot size. A new "radial" pinch-reflex ion diode (i.e., with a radial anode-cathode gap) is found to best demonstrate these properties. Operation in both positive and negative polarities was undertaken, although the negative polarity experiments are emphasized. Particle-in-cell (PIC) simulations are consistent with experimental results indicating that, for diode impedances less than the self-limited impedance of the MITL, almost all of the forward-going IVA vacuum electron flow current is incorporated into the diode current. PIC results also provide understanding of the diode-impedance and ion-focusing properties of the diode. In addition, a substantial high-energy ion population is also identified propagating in the "reverse" direction, i.e., from the back side of the anode foil in the electron beam dump.

  8. Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species.

    PubMed

    Harrison, R A; Oliver, J; Hasson, S S; Bharati, K; Theakston, R D G

    2003-10-01

    Envenoming by Echis saw scaled vipers and Bitis arietans puff adders is the leading cause of death and morbidity in Africa due to snake bite. Despite their medical importance, the composition and constituent functionality of venoms from these vipers remains poorly understood. Here, we report the cloning of cDNA sequences encoding seven clusters or isoforms of the haemostasis-disruptive C-type lectin (CTL) proteins from the venom glands of Echis ocellatus, E. pyramidum leakeyi, E. carinatus sochureki and B. arietans. All these CTL sequences encoded the cysteine scaffold that defines the carbohydrate-recognition domain of mammalian CTLs. All but one of the Echis and Bitis CTL sequences showed greater sequence similarity to the beta than alpha CTL subunits in venoms of related Asian and American vipers. Four of the new CTL clusters showed marked inter-cluster sequence conservation across all four viper species which were significantly different from that of previously published viper CTLs. The other three Echis and Bitis CTL clusters showed varying degrees of sequence similarity to published viper venom CTLs. Because viper venom CTLs exhibit a high degree of sequence similarity and yet exert profoundly different effects on the mammalian haemostatic system, no attempt was made to assign functionality to the new Echis and Bitis CTLs on the basis of sequence alone. The extraordinary level of inter-specific and inter-generic sequence conservation exhibited by the Echis and Bitis CTLs leads us to speculate that antibodies to representative molecules should neutralise the biological function of this important group of venom toxins in vipers that are distributed throughout Africa, the Middle East and the Indian subcontinent. PMID:14557069

  9. Optimization of current waveform tailoring for magnetically driven isentropic compression experiments.

    PubMed

    Waisman, E M; Reisman, D B; Stoltzfus, B S; Stygar, W A; Cuneo, M E; Haill, T A; Davis, J-P; Brown, J L; Seagle, C T; Spielman, R B

    2016-06-01

    The Thor pulsed power generator is being developed at Sandia National Laboratories. The design consists of up to 288 decoupled and transit time isolated capacitor-switch units, called "bricks," that can be individually triggered to achieve a high degree of pulse tailoring for magnetically driven isentropic compression experiments (ICE) [D. B. Reisman et al., Phys. Rev. Spec. Top.-Accel. Beams 18, 090401 (2015)]. The connecting transmission lines are impedance matched to the bricks, allowing the capacitor energy to be efficiently delivered to an ICE strip-line load with peak pressures of over 100 GPa. Thor will drive experiments to explore equation of state, material strength, and phase transition properties of a wide variety of materials. We present an optimization process for producing tailored current pulses, a requirement for many material studies, on the Thor generator. This technique, which is unique to the novel "current-adder" architecture used by Thor, entirely avoids the iterative use of complex circuit models to converge to the desired electrical pulse. We begin with magnetohydrodynamic simulations for a given material to determine its time dependent pressure and thus the desired strip-line load current and voltage. Because the bricks are connected to a central power flow section through transit-time isolated coaxial cables of constant impedance, the brick forward-going pulses are independent of each other. We observe that the desired equivalent forward-going current driving the pulse must be equal to the sum of the individual brick forward-going currents. We find a set of optimal brick delay times by requiring that the L2 norm of the difference between the brick-sum current and the desired forward-going current be a minimum. We describe the optimization procedure for the Thor design and show results for various materials of interest. PMID:27370469

  10. Optimization of current waveform tailoring for magnetically driven isentropic compression experiments

    NASA Astrophysics Data System (ADS)

    Waisman, E. M.; Reisman, D. B.; Stoltzfus, B. S.; Stygar, W. A.; Cuneo, M. E.; Haill, T. A.; Davis, J.-P.; Brown, J. L.; Seagle, C. T.; Spielman, R. B.

    2016-06-01

    The Thor pulsed power generator is being developed at Sandia National Laboratories. The design consists of up to 288 decoupled and transit time isolated capacitor-switch units, called "bricks," that can be individually triggered to achieve a high degree of pulse tailoring for magnetically driven isentropic compression experiments (ICE) [D. B. Reisman et al., Phys. Rev. Spec. Top.-Accel. Beams 18, 090401 (2015)]. The connecting transmission lines are impedance matched to the bricks, allowing the capacitor energy to be efficiently delivered to an ICE strip-line load with peak pressures of over 100 GPa. Thor will drive experiments to explore equation of state, material strength, and phase transition properties of a wide variety of materials. We present an optimization process for producing tailored current pulses, a requirement for many material studies, on the Thor generator. This technique, which is unique to the novel "current-adder" architecture used by Thor, entirely avoids the iterative use of complex circuit models to converge to the desired electrical pulse. We begin with magnetohydrodynamic simulations for a given material to determine its time dependent pressure and thus the desired strip-line load current and voltage. Because the bricks are connected to a central power flow section through transit-time isolated coaxial cables of constant impedance, the brick forward-going pulses are independent of each other. We observe that the desired equivalent forward-going current driving the pulse must be equal to the sum of the individual brick forward-going currents. We find a set of optimal brick delay times by requiring that the L2 norm of the difference between the brick-sum current and the desired forward-going current be a minimum. We describe the optimization procedure for the Thor design and show results for various materials of interest.

  11. Low-pressure pseudospark switches for ICF pulsed power

    NASA Astrophysics Data System (ADS)

    Frank, K.; Bickes, Ch; Ernst, U.; Iberler, M.; Meier, J.; Prucker, U.; Schlaug, M.; Schwab, J.; Urban, J.; Hoffmann, D. H. H.

    Hollow-electrode pseudospark switches are gas-filled, low-pressure, high-current plasma switches which are based on cold cathode emission. They have the capability to satisfy at least a part of switching requirements for different applications in ICF drivers. The main purpose of the submitted paper is therefore to discuss the following realistic ways for the use of pseudospark switches. There are intense international activities aimed at investigating different approaches for the ignition of an ICF capsule. Most of these efforts utilize lasers of varying wavelengths to deliver the energy to initiate the ablation of the target, the compression and ignition of the fuel, and the propagation of the fusion burn. One alternative to this scheme is to provide the drive energy in form of a light ion beam produced by an efficient pulse power accelerator. A related method uses beams of heavy ion beams from high intensity versions of traditional high-energy accelerators. Dependent on the ICF driver for the power conditioning unit (PCU) arise totally different demands. These extremely different requirements mainly rely on the very specific character of the load. Flashlamps, pumping high power lasers represent a non-linear, low-impedance load. Relatively low switching voltage is necessary, but a high charge-transfer capability. Induction cells or magnetic compression units have a high impedance. Consequently high voltage (up to several 100 kV) is required to feed the energy in Marx modules and the following voltage adders produce megavolt voltages, which determines likewise the specific data of the used switch.

  12. Nanowire nanocomputer as a finite-state machine

    PubMed Central

    Yao, Jun; Yan, Hao; Das, Shamik; Klemic, James F.; Ellenbogen, James C.; Lieber, Charles M.

    2014-01-01

    Implementation of complex computer circuits assembled from the bottom up and integrated on the nanometer scale has long been a goal of electronics research. It requires a design and fabrication strategy that can address individual nanometer-scale electronic devices, while enabling large-scale assembly of those devices into highly organized, integrated computational circuits. We describe how such a strategy has led to the design, construction, and demonstration of a nanoelectronic finite-state machine. The system was fabricated using a design-oriented approach enabled by a deterministic, bottom–up assembly process that does not require individual nanowire registration. This methodology allowed construction of the nanoelectronic finite-state machine through modular design using a multitile architecture. Each tile/module consists of two interconnected crossbar nanowire arrays, with each cross-point consisting of a programmable nanowire transistor node. The nanoelectronic finite-state machine integrates 180 programmable nanowire transistor nodes in three tiles or six total crossbar arrays, and incorporates both sequential and arithmetic logic, with extensive intertile and intratile communication that exhibits rigorous input/output matching. Our system realizes the complete 2-bit logic flow and clocked control over state registration that are required for a finite-state machine or computer. The programmable multitile circuit was also reprogrammed to a functionally distinct 2-bit full adder with 32-set matched and complete logic output. These steps forward and the ability of our unique design-oriented deterministic methodology to yield more extensive multitile systems suggest that proposed general-purpose nanocomputers can be realized in the near future. PMID:24469812

  13. Investigating the intrinsic cleanliness of automated handling designed for EUV mask pod-in-pod systems

    NASA Astrophysics Data System (ADS)

    Brux, O.; van der Walle, P.; van der Donck, J. C. J.; Dress, P.

    2011-11-01

    Extreme Ultraviolet Lithography (EUVL) is the most promising solution for technology nodes 16nm (hp) and below. However, several unique EUV mask challenges must be resolved for a successful launch of the technology into the market. Uncontrolled introduction of particles and/or contamination into the EUV scanner significantly increases the risk for device yield loss and potentially scanner down-time. With the absence of a pellicle to protect the surface of the EUV mask, a zero particle adder regime between final clean and the point-of-exposure is critical for the active areas of the mask. A Dual Pod concept for handling EUV masks had been proposed by the industry as means to minimize the risk of mask contamination during transport and storage. SuSS-HamaTech introduces MaskTrackPro InSync as a fully automated solution for the handling of EUV masks in and out of this Dual Pod System and therefore constitutes an interface between various tools inside the Fab. The intrinsic cleanliness of each individual handling and storage step of the inner shell (EIP) of this Dual Pod and the EUV mask inside the InSync Tool has been investigated to confirm the capability for minimizing the risk of cross-contamination. An Entegris Dual Pod EUV-1000A-A110 has been used for the qualification. The particle detection for the qualification procedure was executed with the TNO's RapidNano Particle Scanner, qualified for particle sizes down to 50nm (PSL equivalent). It has been shown that the target specification of < 2 particles @ 60nm per 25 cycles has been achieved. In case where added particles were measured, the EIP has been identified as a potential root cause for Ni particle generation. Any direct Ni-Al contact has to be avoided to mitigate the risk of material abrasion.

  14. Use of a radial self-field diode geometry for intense pulsed ion beam generation at 6 MeV on Hermes III

    SciTech Connect

    Renk, Timothy Jerome; Harper-Slaboszewicz, Victor Jozef; Mikkelson, Kenneth A.; Ginn, W. C.; Ottinger, P. F.; Schumer, J. W.

    2014-12-15

    We investigate the generation of intense pulsed focused ion beams at the 6 MeV level using an inductive voltage adder (IVA) pulsed-power generator, which employs a magnetically insulated transmission line (MITL). Such IVA machines typical run at an impedance of few tens of Ohms. Previous successful intense ion beam generation experiments have often featured an “axial” pinch-reflex ion diode (i.e., with an axial anode-cathode gap) and operated on a conventional Marx generator/water line driver with an impedance of a few Ohms and no need for an MITL. The goals of these experiments are to develop a pinch-reflex ion diode geometry that has an impedance to efficiently match to an IVA, produces a reasonably high ion current fraction, captures the vacuum electron current flowing forward in the MITL, and focuses the resulting ion beam to small spot size. Furthermore, a new “radial” pinch-reflex ion diode (i.e., with a radial anode-cathode gap) is found to best demonstrate these properties. Operation in both positive and negative polarities was undertaken, although the negative polarity experiments are emphasized. Particle-in-cell (PIC) simulations are consistent with experimental results indicating that, for diode impedances less than the self-limited impedance of the MITL, almost all of the forward-going IVA vacuum electron flow current is incorporated into the diode current. PIC results also provide understanding of the diode-impedance and ion-focusing properties of the diode. Additionally, a substantial high-energy ion population is also identified propagating in the “reverse” direction, i.e., from the back side of the anode foil in the electron beam dump.

  15. EUV mask and wafer defectivity: strategy and evaluation for full die defect inspection

    NASA Astrophysics Data System (ADS)

    Bonam, Ravi; Tien, Hung-Yu; Chou, Acer; Meli, Luciana; Halle, Scott; Wu, Ivy; Huang, Xiaoxia; Lei, Chris; Kuan, Chiyan; Wang, Fei; Corliss, Daniel; Fang, Wei; Jau, Jack; Qi, Zhengqing John; Badger, Karen; Turley, Christina; Rankin, Jed

    2016-03-01

    Over the past few years numerous advancements in EUV Lithography have proven its feasibility of insertion into High Volume Manufacturing (HVM).1, 2 A lot of progress is made in the area of pellicle development but a commercially solution with related infrastructure is currently unavailable.3, 4 Due to current mask structure and unavailability of a pellicle, a comprehensive strategy to qualify (native defects) and monitor (adder defects) defectivity on mask and wafer is required for implementing EUV Lithography in High Volume Manufacturing. In this work, we assess multiple strategies for mask and wafer defect inspection including a two-fold solution to leverage resolution of e-beam inspection along with throughput of optical inspection are evaluated. Defect capture rates for inspections based on full-die, critical areas based on priority and hotspots based on design and prior inspection data are evaluated. Each strategy has merits and de-merits, particularly related to throughput, effective die coverage and computational overhead. A production ready EUV Exposure tool was utilized to perform exposures at the IBM EUV Center of Excellence in Albany, NY for EUV Lithography Development along with a fully automated line of EUV Mask Infrastructure tools. We will present strategies considered in this study and discuss respective results. The results from the study indicate very low transfer rate of defect detection events from optical mask inspection. They also suggest a hybrid strategy of utilizing both optical and e-beam inspection can provide a comprehensive defect detection which can be employed in High Volume Manufacturing.

  16. Comparison between Frame-Constrained Fix-Pixel-Value and Frame-Free Spiking-Dynamic-Pixel ConvNets for Visual Processing

    PubMed Central

    Farabet, Clément; Paz, Rafael; Pérez-Carrasco, Jose; Zamarreño-Ramos, Carlos; Linares-Barranco, Alejandro; LeCun, Yann; Culurciello, Eugenio; Serrano-Gotarredona, Teresa; Linares-Barranco, Bernabe

    2012-01-01

    Most scene segmentation and categorization architectures for the extraction of features in images and patches make exhaustive use of 2D convolution operations for template matching, template search, and denoising. Convolutional Neural Networks (ConvNets) are one example of such architectures that can implement general-purpose bio-inspired vision systems. In standard digital computers 2D convolutions are usually expensive in terms of resource consumption and impose severe limitations for efficient real-time applications. Nevertheless, neuro-cortex inspired solutions, like dedicated Frame-Based or Frame-Free Spiking ConvNet Convolution Processors, are advancing real-time visual processing. These two approaches share the neural inspiration, but each of them solves the problem in different ways. Frame-Based ConvNets process frame by frame video information in a very robust and fast way that requires to use and share the available hardware resources (such as: multipliers, adders). Hardware resources are fixed- and time-multiplexed by fetching data in and out. Thus memory bandwidth and size is important for good performance. On the other hand, spike-based convolution processors are a frame-free alternative that is able to perform convolution of a spike-based source of visual information with very low latency, which makes ideal for very high-speed applications. However, hardware resources need to be available all the time and cannot be time-multiplexed. Thus, hardware should be modular, reconfigurable, and expansible. Hardware implementations in both VLSI custom integrated circuits (digital and analog) and FPGA have been already used to demonstrate the performance of these systems. In this paper we present a comparison study of these two neuro-inspired solutions. A brief description of both systems is presented and also discussions about their differences, pros and cons. PMID:22518097

  17. Use of a radial self-field diode geometry for intense pulsed ion beam generation at 6 MeV on Hermes III

    DOE PAGESBeta

    Renk, Timothy Jerome; Harper-Slaboszewicz, Victor Jozef; Mikkelson, Kenneth A.; Ginn, W. C.; Ottinger, P. F.; Schumer, J. W.

    2014-12-15

    We investigate the generation of intense pulsed focused ion beams at the 6 MeV level using an inductive voltage adder (IVA) pulsed-power generator, which employs a magnetically insulated transmission line (MITL). Such IVA machines typical run at an impedance of few tens of Ohms. Previous successful intense ion beam generation experiments have often featured an “axial” pinch-reflex ion diode (i.e., with an axial anode-cathode gap) and operated on a conventional Marx generator/water line driver with an impedance of a few Ohms and no need for an MITL. The goals of these experiments are to develop a pinch-reflex ion diode geometrymore » that has an impedance to efficiently match to an IVA, produces a reasonably high ion current fraction, captures the vacuum electron current flowing forward in the MITL, and focuses the resulting ion beam to small spot size. Furthermore, a new “radial” pinch-reflex ion diode (i.e., with a radial anode-cathode gap) is found to best demonstrate these properties. Operation in both positive and negative polarities was undertaken, although the negative polarity experiments are emphasized. Particle-in-cell (PIC) simulations are consistent with experimental results indicating that, for diode impedances less than the self-limited impedance of the MITL, almost all of the forward-going IVA vacuum electron flow current is incorporated into the diode current. PIC results also provide understanding of the diode-impedance and ion-focusing properties of the diode. Additionally, a substantial high-energy ion population is also identified propagating in the “reverse” direction, i.e., from the back side of the anode foil in the electron beam dump.« less

  18. Comparison between Frame-Constrained Fix-Pixel-Value and Frame-Free Spiking-Dynamic-Pixel ConvNets for Visual Processing.

    PubMed

    Farabet, Clément; Paz, Rafael; Pérez-Carrasco, Jose; Zamarreño-Ramos, Carlos; Linares-Barranco, Alejandro; Lecun, Yann; Culurciello, Eugenio; Serrano-Gotarredona, Teresa; Linares-Barranco, Bernabe

    2012-01-01

    Most scene segmentation and categorization architectures for the extraction of features in images and patches make exhaustive use of 2D convolution operations for template matching, template search, and denoising. Convolutional Neural Networks (ConvNets) are one example of such architectures that can implement general-purpose bio-inspired vision systems. In standard digital computers 2D convolutions are usually expensive in terms of resource consumption and impose severe limitations for efficient real-time applications. Nevertheless, neuro-cortex inspired solutions, like dedicated Frame-Based or Frame-Free Spiking ConvNet Convolution Processors, are advancing real-time visual processing. These two approaches share the neural inspiration, but each of them solves the problem in different ways. Frame-Based ConvNets process frame by frame video information in a very robust and fast way that requires to use and share the available hardware resources (such as: multipliers, adders). Hardware resources are fixed- and time-multiplexed by fetching data in and out. Thus memory bandwidth and size is important for good performance. On the other hand, spike-based convolution processors are a frame-free alternative that is able to perform convolution of a spike-based source of visual information with very low latency, which makes ideal for very high-speed applications. However, hardware resources need to be available all the time and cannot be time-multiplexed. Thus, hardware should be modular, reconfigurable, and expansible. Hardware implementations in both VLSI custom integrated circuits (digital and analog) and FPGA have been already used to demonstrate the performance of these systems. In this paper we present a comparison study of these two neuro-inspired solutions. A brief description of both systems is presented and also discussions about their differences, pros and cons. PMID:22518097

  19. Optical analog-to-digital converter

    NASA Technical Reports Server (NTRS)

    Evanchuk, Vincent L. (Inventor)

    1984-01-01

    A method and apparatus for converting the intensity of an unknown optical signal (B) into an electrical signal in digital form utilizes two elongated optical attenuators (11, 13), one for the unknown optical signal from a source (10) and one for a known optical signal (A) from a variable source (12), a plurality of photodetectors (e.g., 17, 18) along each attenuator for detecting the intensity of the optical signals, and a plurality of comparators (e.g., 21) connected to the photodetectors in pairs to determine at what points being compared the attenuated known signal equals the attenuated unknown signal. The intensity of the unknown relative to the known is thus determined by the output of a particular comparator. That output is automatically encoded to a relative intensity value in digital form through a balancing feedback control (24) and encoder (23). The digital value may be converted to analog form in a D-to-A converter (27) and used to vary the source of the known signal so that the attenuated intensity of the known signal at a predetermined point (comparator 16) equals the attenuated intensity of the unknown signal at the predetermined point of comparison. If the known signal is then equal to the unknown, there is verification of the analog-to-digital conversion being complete. Otherwise the output of the comparator indicating equality at some other point along the attenuators will provide an output which is encoded and added, through an accumulator comprised of a register (25) and an adder (26), to a previous relative intensity value thereby to further vary the intensity of the known signal source. The steps are repeated until full conversion is verified.

  20. 8-Channel acquisition system for Time-Correlated Single-Photon Counting.

    PubMed

    Antonioli, S; Miari, L; Cuccato, A; Crotti, M; Rech, I; Ghioni, M

    2013-06-01

    Nowadays, an increasing number of applications require high-performance analytical instruments capable to detect the temporal trend of weak and fast light signals with picosecond time resolution. The Time-Correlated Single-Photon Counting (TCSPC) technique is currently one of the preferable solutions when such critical optical signals have to be analyzed and it is fully exploited in biomedical and chemical research fields, as well as in security and space applications. Recent progress in the field of single-photon detector arrays is pushing research towards the development of high performance multichannel TCSPC systems, opening the way to modern time-resolved multi-dimensional optical analysis. In this paper we describe a new 8-channel high-performance TCSPC acquisition system, designed to be compact and versatile, to be used in modern TCSPC measurement setups. We designed a novel integrated circuit including a multichannel Time-to-Amplitude Converter with variable full-scale range, a D∕A converter, and a parallel adder stage. The latter is used to adapt each converter output to the input dynamic range of a commercial 8-channel Analog-to-Digital Converter, while the integrated DAC implements the dithering technique with as small as possible area occupation. The use of this monolithic circuit made the design of a scalable system of very small dimensions (95 × 40 mm) and low power consumption (6 W) possible. Data acquired from the TCSPC measurement are digitally processed and stored inside an FPGA (Field-Programmable Gate Array), while a USB transceiver allows real-time transmission of up to eight TCSPC histograms to a remote PC. Eventually, the experimental results demonstrate that the acquisition system performs TCSPC measurements with high conversion rate (up to 5 MHz/channel), extremely low differential nonlinearity (<0.04 peak-to-peak of the time bin width), high time resolution (down to 20 ps Full-Width Half-Maximum), and very low crosstalk between channels

  1. MOSFET-like CNFET based logic gate library for low-power application: a comparative study

    NASA Astrophysics Data System (ADS)

    Gowri Sankar, P. A.; Udhayakumar, K.

    2014-07-01

    The next generation of logic gate devices are expected to depend upon radically new technologies mainly due to the increasing difficulties and limitations of existing CMOS technology. MOSFET like CNFETs should ideally be the best devices to work with for high-performance VLSI. This paper presents results of a comprehensive comparative study of MOSFET-like carbon nanotube field effect transistors (CNFETs) technology based logic gate library for high-speed, low-power operation than conventional bulk CMOS libraries. It focuses on comparing four promising logic families namely: complementary-CMOS (C-CMOS), transmission gate (TG), complementary pass logic (CPL) and Domino logic (DL) styles are presented. Based on these logic styles, the proposed library of static and dynamic NAND-NOR logic gates, XOR, multiplexer and full adder functions are implemented efficiently and carefully analyzed with a test bench to measure propagation delay and power dissipation as a function of supply voltage. This analysis provides the right choice of logic style for low-power, high-speed applications. Proposed logic gates libraries are simulated using Synopsys HSPICE based on the standard 32 nm CNFET model. The simulation results demonstrate that, it is best to use C-CMOS logic style gates that are implemented in CNFET technology which are superior in performance compared to other logic styles, because of their low average power-delay-product (PDP). The analysis also demonstrates how the optimum supply voltage varies with logic styles in ultra-low power systems. The robustness of the proposed logic gate library is also compared with conventional and state-art of CMOS logic gate libraries.

  2. Climate and environment of the earliest West European hominins inferred from amphibian and squamate reptile assemblages: Sima del Elefante Lower Red Unit, Atapuerca, Spain

    NASA Astrophysics Data System (ADS)

    Blain, Hugues-Alexandre; Bailon, Salvador; Cuenca-Bescós, Gloria; Bennàsar, Maria; Rofes, Juan; López-García, Juan Manuel; Huguet, Rosa; Arsuaga, Juan Luis; Bermúdez de Castro, José Maria; Carbonell, Eudald

    2010-11-01

    The Sima del Elefante cave, in the Sierra de Atapuerca (Burgos, Spain), is famous for the fact that level TE9 of its Lower Red Unit recently delivered the oldest hominin remains of Western Europe, identified as Homo antecessor and dated by biostratigraphy and radiometric methods to ca 1.2 Ma. Given the importance of this discovery, every effort is being made to reconstruct the landscapes where these hominins once thrived. The amphibian and squamate reptile assemblage of the Sima del Elefante Lower Red Unit is here studied for the first time. The faunal list comprises at least 17 species (roughly 12,000 bone fossil remains): Salamandra salamandra, Triturus cf. marmoratus, Alytes obstetricans, Pelobates cultripes, Pelodytes punctatus, Bufo bufo, Bufo calamita, Hyla arborea, Rana sp., cf. Pelophylax sp., Lacerta s.l., small-sized indeterminate lacertids, Anguis fragilis, Natrix cf. natrix, Natrix cf. maura, Coronella cf. girondica and Vipera sp. As the amphibians and squamate reptiles do not differ at species level from the extant herpetofauna of the Iberian Peninsula, they can contribute to the reconstruction of the landscape and climate. In this paper, the mutual climatic range and habitat weighting methods are applied to the amphibian and squamate reptile assemblages in order to estimate quantitative data. The results from the squamate and amphibian study indicate that during the hominin presence the mean annual temperature (MAT = 10-13 °C) was always slightly warmer than at present and the mean annual precipitation (MAP = 800-1000 mm) was greater than today in the Burgos area. The landscape had open habitats in the vicinity of the Atapuerca caves throughout the sequence, with wet points in the surrounding area, and a predominance of humid meadows and open woodlands. These results mainly agree with those for large mammals, small mammals and the pollen analysis. The climate and landscape of TE-LRU are very similar to those reconstructed for the TD6 "Aurora Stratum

  3. Some anomalous behaviour of vertebrates and insects preceding M5+ earthquakes in the North Western Apennines (Italy)

    NASA Astrophysics Data System (ADS)

    Straser, Valentino

    2013-04-01

    Earthquakes with a magnitude greater than M5+ are an unusual event in the seismic area of the Frignano District and the areas surrounding Parma in the North Western Apennines (Italy). Only two seismic events have occurred in the last four years: on 23 December 2008 (M5.1) and on 27 January 2012 (M5.4). The earthquake of 23 December 2008 allowed the verification of unusual behaviour in man and animals in the run-up to the main shock, in addition to anomalies of an electromagnetic type. An initial study showed that there are elements of coincidence between the seismic events and the number of admissions to hospitals around the epicentre: in the month of December 2008, the days with the greatest number of admissions coincided with seismic shocks. A half hour before the main event of 23 December, recorded at 16:24:21 local time (see: INGV), a slowworm (Anguis fragilis) left its hibernation site and died shortly afterwards from the cold on a road, as did a viper (Vipera aspis) found near some dwellings in an area around twenty kilometres from the epicentre. The investigation proceeded in 2009, but this time based on the number of daily admissions to the hospital A&E department, between June and December 2009. During the six months of the investigation, the maximum number of emergencies was 9 per day, while the earthquakes were in line with the usual number and magnitude for the Frignano seismic district. The earthquakes from June to December 2009 numbered 10, with a magnitude from M2.5 to M3.6. In 8 cases, in the 48 hours preceding the occurrence of the seism, there was a greater number of hospital emergencies. The subsequent occasion to check on a possible relationship between anomalous behaviour in animals and a seism occurred on 27 January 2012 (see: INGV), when an earthquake with a magnitude of M5.4 shook the North Western Apennines, thankfully without resulting in victims. Like 2008, in an area around fifteen kilometres from the epicentre, a grass snake (Zamenis

  4. P-23 Highlights 6/10/12: Cygnus Dual Beam Radiographic Facility Refurbishment completed at U1A tunnel in Nevada NNSS meeting Level 2 milestone

    SciTech Connect

    Deyoung, Anemarie; Smith, John R.

    2012-05-03

    A moratorium was placed on U.S. underground nuclear testing in 1992. In response, the Stockpile Stewardship Program was created to maintain readiness of the existing nuclear inventory through several efforts such as computer modeling, material analysis, and subcritical nuclear experiments (SCEs). As in the underground test era, the Nevada National Security Site (NNSS), formerly the Nevada Test Site, provides a safe and secure environment for SCEs by the nature of its isolated and secure facilities. A major tool for SCE diagnosis installed in the 05 drift laboratory is a high energy x-ray source used for time resolved imaging. This tool consists of two identical sources (Cygnus 1 and Cygnus 2) and is called the Cygnus Dual Beam Radiographic Facility (Figs. 2-6). Each Cygnus machine has 5 major elements: Marx Generator, Pulse Forming Line (PFL), Coaxial Transmission Line (CTL), 3-cell Inductive Voltage Adder (IVA), and Rod Pinch Diode. Each machine is independently triggered and may be fired in separate tests (staggered mode), or in a single test where there is submicrosecond separation between the pulses (dual mode). Cygnus must operate as a single shot machine since on each pulse the diode electrodes are destroyed. The diode is vented to atmosphere, cleaned, and new electrodes are inserted for each shot. There is normally two shots per day on each machine. Since its installation in 2003, Cygnus has participated in: 4 Subcritical Experiments (Armando, Bacchus, Barolo A, and Barolo B), a 12 shot plutonium physics series (Thermos), and 2 plutonium step wedge calibration series (2005, 2011), resulting in well over 1000 shots. Currently the Facility is in preparation for 2 SCEs scheduled for this calendar year - Castor and Pollux. Cygnus has performed well during 8 years of operations at NNSS. Many improvements in operations and performance have been implemented during this time. Throughout its service at U1a, major maintenance and replacement of many hardware items

  5. Block QCA Fault-Tolerant Logic Gates

    NASA Technical Reports Server (NTRS)

    Firjany, Amir; Toomarian, Nikzad; Modarres, Katayoon

    2003-01-01

    Suitably patterned arrays (blocks) of quantum-dot cellular automata (QCA) have been proposed as fault-tolerant universal logic gates. These block QCA gates could be used to realize the potential of QCA for further miniaturization, reduction of power consumption, increase in switching speed, and increased degree of integration of very-large-scale integrated (VLSI) electronic circuits. The limitations of conventional VLSI circuitry, the basic principle of operation of QCA, and the potential advantages of QCA-based VLSI circuitry were described in several NASA Tech Briefs articles, namely Implementing Permutation Matrices by Use of Quantum Dots (NPO-20801), Vol. 25, No. 10 (October 2001), page 42; Compact Interconnection Networks Based on Quantum Dots (NPO-20855) Vol. 27, No. 1 (January 2003), page 32; Bit-Serial Adder Based on Quantum Dots (NPO-20869), Vol. 27, No. 1 (January 2003), page 35; and Hybrid VLSI/QCA Architecture for Computing FFTs (NPO-20923), which follows this article. To recapitulate the principle of operation (greatly oversimplified because of the limitation on space available for this article): A quantum-dot cellular automata contains four quantum dots positioned at or between the corners of a square cell. The cell contains two extra mobile electrons that can tunnel (in the quantummechanical sense) between neighboring dots within the cell. The Coulomb repulsion between the two electrons tends to make them occupy antipodal dots in the cell. For an isolated cell, there are two energetically equivalent arrangements (denoted polarization states) of the extra electrons. The cell polarization is used to encode binary information. Because the polarization of a nonisolated cell depends on Coulomb-repulsion interactions with neighboring cells, universal logic gates and binary wires could be constructed, in principle, by arraying QCA of suitable design in suitable patterns. Heretofore, researchers have recognized two major obstacles to realization of QCA

  6. Analysis of camelid antibodies for antivenom development: Neutralisation of venom-induced pathology.

    PubMed

    Cook, Darren A N; Owen, Timothy; Wagstaff, Simon C; Kinne, Joerg; Wernery, Ulrich; Harrison, Robert A

    2010-09-01

    Camelid IgG has been reported to be less immunogenic, less able to activate the complement cascade and more thermostable than IgG from other mammals, and has the ability to bind antigens that are unreactive with other mammalian IgGs. We are investigating whether these attributes of camelid IgG translate into antivenom with immunological and venom-neutralising efficacy advantages over conventional equine and ovine antivenoms. The objective of this study was to determine the preclinical venom-neutralising effectiveness of IgG from camels immunised with venoms, individually or in combination, of the saw-scaled viper, Echis ocellatus, the puff adder, Bitis arietans and the spitting cobra, Naja nigricollis - the most medically-important snake species in West Africa. Neutralisation of the pathological effects of venoms from E. ocellatus, B. arietans and N. nigricollis by IgG from the venom-immunised camels, or commercial antivenom, was compared using assays of venom lethality (ED(50)), haemorrhage (MHD) and coagulopathy (MCD). The E. ocellatus venom ED(50), MHD and MCD results of the E. ocellatus monospecific camel IgG antivenom were broadly equivalent to comparable ovine (EchiTAbG, MicroPharm Ltd, Wales) and equine (SAIMR Echis, South African Vaccine Producer, South Africa) antivenoms, although the equine antivenom required half the amount of IgG. The B. arietans monospecific camel IgG neutralised the lethal effects of B. arietans venom at one fourth the concentration of the SAIMR polyspecific antivenom (a monospecific B. arietans antivenom is not available). The N. nigricollis camel IgG antivenom was ineffective (at the maximum permitted dose, 100 mul) against the lethal effects of N. nigricollis venom. All the equine polyspecific antivenoms required more than 100 microl to be effective against this venom. The polyspecific camel IgG antivenom, prepared from five camels, was effective against the venom-induced effects of E. ocellatus but not against that of B. arietans

  7. Advances in CO2 cryogenic aerosol technology for photomask post AFM repair

    NASA Astrophysics Data System (ADS)

    Bowers, Charles; Varghese, Ivin; Balooch, Mehdi; Rodriguez, Jaime

    2009-10-01

    As the mask technology moves towards production of 36 nm and 22 nm DRAM half pitch nodes, printing features and sub-resolution assist features (SRAF) shrink below 80 nm. These narrow features become more fragile and place new demands on cleaning processes for a physically non damaging solution. These challenges include compatibility with new materials, oxidation, chemical contamination sensitivity, proportionally decreasing printable defect size, and a requirement for a damage-free clean. CO2 cryogenic aerosol cleaning has, for many years, shown potential to offer a wide process window for meeting some of these new challenges. CO2 cryogenic aerosol cleaning for post AFM repair debris cleaning has been used for many years on masks greater than 90 nm DRAM half pitch nodes. Until recently, CO2 purity and delivery hardware issues resulted in foreign material adder (FMACO2) contamination and SRAF damage below 150 nm critical feature size. Some key desirable properties of CO2 cryogenic aerosol cleaning are the non-oxidizing and non-etching properties when compared to current chemical wet clean processes. In this paper, recent advancements of CO2 cryogenic aerosol cleaning technology are presented, highlighting improvements in the areas of FMACO2 reduction, lowering the critical feature size without damage, and electrostatic discharge (ESD) mitigation. Key aspects of successful CO2 cryogenic aerosol cleaning include the spray nozzle design, CO2 liquid purity, and integrated system design. The design of the nozzle directly controls the size, flux, and velocity of the CO2 snow particles. Methodology and measurements of the solid CO2 particle size and velocity distributions will be presented, and their responses to various control parameters will be discussed. FMACO2 mitigation can be achieved only through use of highly purified CO2 and careful materials selection of the delivery hardware. Recent advances in CO2 purity will be discussed and data shown. The mask cleaning

  8. Evolutionary and Disruptive Approaches for Designing Next-Generation Ultra Energy-Efficient Electronics

    NASA Astrophysics Data System (ADS)

    Dadgour, Hamed F.

    analyzed. It is shown that such devices can be employed to implement highly energy-efficient and ultra compact XOR gates, which are the key building blocks for more complex computational units. The lateral NEMS device also creates new opportunities in Boolean logic minimization and seems promising for implementing high-performance arithmetic modules (such as Adders). A comprehensive scaling analysis of the NEMS devices is also conducted to identify the key challenges that must be overcome before such transistors can be incorporated in the mainstream IC technologies.

  9. Nanoscale Magnetic Materials for Energy-Efficient Spin Based Transistors

    NASA Astrophysics Data System (ADS)

    Incorvia, Jean Anne Currivan

    In this dissertation, I study the physical behavior of nanoscale magnetic materials and build spin-based transistors that encode information in magnetic domain walls. It can be argued that energy dissipation is the most serious problem in modern electronics, and one that has been resistant to a breakthrough. Wasted heat during computing both wastes energy and hinders further technology scaling. This is an opportunity for physicists and engineers to come up with creative solutions for more energy-efficient computing. I present the device we have designed, called domain wall logic (DW-Logic). Information is stored in the position of a magnetic domain wall in a ferromagnetic wire and read out using a magnetic tunnel junction. This hybrid design uses electrical current as the input and output, keeping the device compatible with charge- based transistors. I build an iterative model to predict both the micromagnetic and circuit behavior of DW- Logic, showing a single device can operate as a universal gate. The model shows we can build complex circuits including an 18-gate Full Adder, and allows us to predict the device switching energy compared to complementary metal-oxide semiconductor (CMOS) transistors. Comparing ?15 nm feature nodes, I find DW-Logic made with perpendicular magnetic anisotropy materials, and utilizing both spin torque transfer and the Spin Hall effect, could operate with 1000x reduced switching energy compared to CMOS. I fabricate DW-Logic device prototypes and show in experiment they can act as AND and NAND gates. I demonstrate that one device can drive two subsequent devices, showing gain, which is a necessary requirement for fanout. I also build a clocked ring oscillator circuit to demonstrate successful bit propagation in a DW-Logic circuit and show that properly scaled devices can have improved operation. Through building the devices, I develop a novel fabrication method for patterning sub-25 nm magnetic wires with very low (˜ 2 nm) average edge

  10. Physical and timing verification of subwavelength-scale designs: I. Lithography impact on MOSFETs

    NASA Astrophysics Data System (ADS)

    Pack, Robert C.; Axelrad, Valery; Shibkov, Andrei; Boksha, Victor V.; Huckabay, Judy A.; Salik, Rachid; Staud, Wolfgang; Wang, Ruoping; Grobman, Warren D.

    2003-07-01

    Subwavelength lithography at low contrast, or low-k1 factor, leads to new requirements for design, design analysis, and design verification techniques. These techniques must account for inherent physical circuit feature distortions resulting from layout pattern-dependent design-to-silicon patterning processes in this era. These distortions are unavoidable, even in the presence of sophisticated Resolution Enhancement Technologies (RET), and are a 'fact-of-life" for the designer implementing nanometer-scale designs for the foreseeable low-k1 future. The consequence is that fabricated silicon feature shapes and dimensions are in general printed with far less fidelity in comparison to the designer"s desired layout than in past generations and that the designer must consider design within significantly different margins of geometry tolerance. Traditional (Mead-Conway originated) WYSIWYG (what you see is what you get) design methodologies, assume that the designer"s physical circuit element shapes are accurate in comparison to the corresponding shapes on the real fabricated IC, and uses design rules to verify satisfactory fabrication compliance, as the input for both interconnect parasitic loading calculations and to transistor models used for performance simulation. However, these assumptions are increasingly poor ones as k1 decreases to unprecidented levels -- with concomitant increase in patterned feature distortion and fabrication yield failure modes. This paper explores a new paradigm for nanometer-scale design, one in which more advanced models of critical low-k1 lithographic printing effects are incorporated into the design flow to improve upon yield and performance verification accuracy. We start with an analysis of a complex 32-bit adder block circuit design to determine systematic changes in gate length, width and shape variations for each MOSFET in the circuit due to optical proximity effects. The physical gate dimensions for all, as predicted by the

  11. Wide Range SET Pulse Measurement

    NASA Technical Reports Server (NTRS)

    Shuler, Robert L.; Chen, Li

    2012-01-01

    A method for measuring a wide range of SET pulses is demonstrated. Use of dynamic logic, faster than ordinary CMOS, allows capture of short pulses. A weighted binning of SET lengths allows measurement of a wide range of pulse lengths with compact circuitry. A pulse-length-conservative pulse combiner tree routes SETs from combinational logic to the measurement circuit, allowing SET measurements in circuits that cannot easily be arranged in long chains. The method is applied to add-multiplex combinational logic, and to an array of NFET routing switches, at .35 micron. Pulses are captured in a chain of Domino Logic AND gates. Propagation through the chain is frozen on the trailing edge by dropping low the second "enable" input to the AND gates. Capacitive loading is increased in the latter stages to create an approximately logarithmic weighted binning, so that a broad range of pulse lengths can be captured with a 10 stage capture chain. Simulations show pulses can be captured which are 1/5th the length of those typically captured with leading edge triggered latch methods, and less than the length of those captured with a trailing edge latch method. After capture, the pulse pattern is transferred to an SEU protected shift register for readout. 64 instances of each of two types of logic are used as targets. One is a full adder with a 4 to 1 mux on its inputs. The other is a 4 x 4 NFET routing matrix. The outputs are passed through buffered XNOR comparators to identify pulses, which are merged in a buffered not-nand (OR) tree designed to avoid pulse absorption as much as possible. The output from each of the two test circuits are input into separate pulse measurement circuits. Test inputs were provided so that the circuit could be bench tested and calibrated. A third SET measurement circuit with no inputs was used to judge the contribution from direct hits on the measurement circuit. Heavy ions were used with an LET range from 12 to 176. At LET of 21 and below, the very

  12. Recyclable transmission line (RTL) and linear transformer driver (LTD) development for Z-pinch inertial fusion energy (Z-IFE) and high yield.

    SciTech Connect

    Sharpe, Robin Arthur; Kingsep, Alexander S. (Kurchatov Institute, Moscow, Russia); Smith, David Lewis; Olson, Craig Lee; Ottinger, Paul F. (Naval Research Laboratory, Washington, DC); Schumer, Joseph Wade (Naval Research Laboratory, Washington, DC); Welch, Dale Robert (Voss Scientific, Albuquerque, NM); Kim, Alexander (High Currents Institute, Tomsk, Russia); Kulcinski, Gerald L. (University of Wisconsin, Madison, WI); Kammer, Daniel C. (University of Wisconsin, Madison, WI); Rose, David Vincent (Voss Scientific, Albuquerque, NM); Nedoseev, Sergei L. (Kurchatov Institute, Moscow, Russia); Pointon, Timothy David; Smirnov, Valentin P.; Turgeon, Matthew C.; Kalinin, Yuri G. (Kurchatov Institute, Moscow, Russia); Bruner, Nichelle "Nicki" (Voss Scientific, Albuquerque, NM); Barkey, Mark E. (University of Alabama, Tuscaloosa, AL); Guthrie, Michael (University of Wisconsin, Madison, WI); Thoma, Carsten (Voss Scientific, Albuquerque, NM); Genoni, Tom C. (Voss Scientific, Albuquerque, NM); Langston, William L.; Fowler, William E.; Mazarakis, Michael Gerrassimos

    2007-01-01

    demonstrated at the SNL Z-IFE LTD laboratory with rep-rates up to 10.3 seconds between shots (this is essentially at the goal of 10 seconds for Z-IFE). (7) A single LTD switch at Tomsk was fired repetitively every 12 seconds for 36,000 shots with no failures. (8) Five 1.0 MA, 100 kV, 100 ns, LTD cavities have been combined into a voltage adder configuration with a test load to successfully study the system operation. (9) The combination of multiple LTD coaxial lines into a tri-plate transmission line is examined. The 3D Quicksilver code is used to study the electron flow losses produced near the magnetic nulls that occur where coax LTD lines are added together. (10) Circuit model codes are used to model the complete power flow circuit with an inductive isolator cavity. (11) LTD architectures are presented for drivers for Z-IFE and high yield. A 60 MA LTD driver and a 90 MA LTD driver are proposed. Present results from all of these power flow studies validate the whole LTD/RTL concept for single-shot ICF high yield, and for repetitive-shot IFE.

  13. Extending CO2 cryogenic aerosol cleaning for advanced optical and EUV mask cleaning

    NASA Astrophysics Data System (ADS)

    Varghese, Ivin; Bowers, Charles W.; Balooch, Mehdi

    2011-11-01

    Cryogenic CO2 aerosol cleaning being a dry, chemically-inert and residue-free process is used in the production of optical lithography masks. It is an attractive cleaning option for the mask industry to achieve the requirement for removal of all printable soft defects and repair debris down to the 50nm printability specification. In the technique, CO2 clusters are formed by sudden expansion of liquid from high to almost atmospheric pressure through an optimally designed nozzle orifice. They are then directed on to the soft defects or debris for momentum transfer and subsequent damage free removal from the mask substrate. Unlike aggressive acid based wet cleaning, there is no degradation of the mask after processing with CO2, i.e., no critical dimension (CD) change, no transmission/phase losses, or chemical residue that leads to haze formation. Therefore no restriction on number of cleaning cycles is required to be imposed, unlike other cleaning methods. CO2 aerosol cleaning has been implemented for several years as full mask final clean in production environments at several state of the art mask shops. Over the last two years our group reported successful removal of all soft defects without damage to the fragile SRAF features, zero adders (from the cleaning and handling mechanisms) down to a 50nm printability specification. In addition, CO2 aerosol cleaning is being utilized to remove debris from Post-RAVE repair of hard defects in order to achieve the goal of no printable defects. It is expected that CO2 aerosol cleaning can be extended to extreme ultraviolet (EUV) masks. In this paper, we report advances being made in nozzle design qualification for optimum snow properties (size, velocity and flux) using Phase Doppler Anemometry (PDA) technique. In addition the two new areas of focus for CO2 aerosol cleaning i.e. pellicle glue residue removal on optical masks, and ruthenium (Ru) film on EUV masks are presented. Usually, the residue left over after the pellicle

  14. Nanoparticle removal using laser induced plasma (LIP) technique and study of detachment modes based on molecular dynamics simulations

    NASA Astrophysics Data System (ADS)

    Peri, M. D. Murthy

    Nanoparticle contamination is a major problem in many industries. In the semiconductor industry, as the device (integrated circuit) size shrinks with each technological node (DRAM half-pitch), the feature size that has to be fabricated shrinks. Consequently, the minimum tolerable particle defect size also reduces to sub-100 nm level. In order to attain the stringent small size features, Extreme Ultraviolet Lithography (EUVL) technique is being explored in the semiconductor industry. As the EUVL masks are reflective and pellicle free, the cleaning techniques employed to remove the native particle defects must be more effective for the removal of the sub-100 nm particles without any substrate damage. The effectiveness of Laser Induced Plasma (LIP) technique, considered as a next generation cleaning method, for removal of 30 nm PSL particles from silicon substrate was previously demonstrated by our group. In the current study, the removal of 100 nm PSL particles from photomask and 300 nm PSL particles from 500 nm patterns was investigated. It was observed that the patterns were damaged which could be attributed to the radiation heating of the plasma, and this necessitated pressure amplification techniques to amplify the transient pressure and minimize the risk of damage. As a potential solution, shocktubes were designed and transient pressure measurements were carried out in air medium. Also, plasma was generated in water, in order to take advantage of the density of the medium, to generate stronger shocks and consequently higher pressure. The performance of the shocktubes was characterized based on their pressure amplification factor. The shocktubes resulted in a pressure amplification factor of 11 in air. The particle removal experiments with shocktubes on 150 nm patterns were performed and no damage to the patterns was observed. However, there were particle adders due to the ablation of the shocktube material. Molecular Dynamics (MD) simulations were initiated and