77 FR 20830 - Determination of Regulatory Review Period for Purposes of Patent Extension; VIIBRYD

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

...) and the Generic Animal Drug and Patent Term Restoration Act (Pub. L. 100-670) generally provide that a..., animal drug product, medical device, food additive, or color additive) was subject to regulatory review... consists of two periods of time: A testing phase and an approval phase. For human drug products, the...

Analysis and comparison of wrist splint designs using the finite element method: Multi-material three-dimensional printing compared to typical existing practice with thermoplastics.

PubMed

Cazon, Aitor; Kelly, Sarah; Paterson, Abby M; Bibb, Richard J; Campbell, R Ian

2017-09-01

Rheumatoid arthritis is a chronic disease affecting the joints. Treatment can include immobilisation of the affected joint with a custom-fitting splint, which is typically fabricated by hand from low temperature thermoplastic, but the approach poses several limitations. This study focused on the evaluation, by finite element analysis, of additive manufacturing techniques for wrist splints in order to improve upon the typical splinting approach. An additive manufactured/3D printed splint, specifically designed to be built using Objet Connex multi-material technology and a virtual model of a typical splint, digitised from a real patient-specific splint using three-dimensional scanning, were modelled in computer-aided design software. Forty finite element analysis simulations were performed in flexion-extension and radial-ulnar wrist movements to compare the displacements and the stresses. Simulations have shown that for low severity loads, the additive manufacturing splint has 25%, 76% and 27% less displacement in the main loading direction than the typical splint in flexion, extension and radial, respectively, while ulnar values were 75% lower in the traditional splint. For higher severity loads, the flexion and extension movements resulted in deflections that were 24% and 60%, respectively, lower in the additive manufacturing splint. However, for higher severity loading, the radial defection values were very similar in both splints and ulnar movement deflection was higher in the additive manufacturing splint. A physical prototype of the additive manufacturing splint was also manufactured and was tested under normal conditions to validate the finite element analysis data. Results from static tests showed maximum displacements of 3.46, 0.97, 3.53 and 2.51 mm flexion, extension, radial and ulnar directions, respectively. According to these results, the present research argues that from a technical point of view, the additive manufacturing splint design stands at the same or even better level of performance in displacements and stress values in comparison to the typical low temperature thermoplastic approach and is therefore a feasible approach to splint design and manufacture.

AFWAL FY80 Technical Accomplishments Report.

DTIC Science & Technology

1981-12-01

through cooperative effort of the Materials and Certain compositions in the titanium aluminide Propulsion Laboratories. In addition to an extensive system...Bonded Structures Technology Transitioned .................................................. 43 Superplastically Formed and Diffusion Bonded Titanium ...Technology ................................................................................................. 75 First RSR Radial Wafer Blade Engine Test

Biomechanical comparison of four C1 to C2 rigid fixative techniques: anterior transarticular, posterior transarticular, C1 to C2 pedicle, and C1 to C2 intralaminar screws.

PubMed

Lapsiwala, Samir B; Anderson, Paul A; Oza, Ashish; Resnick, Daniel K

2006-03-01

We performed a biomechanical comparison of several C1 to C2 fixation techniques including crossed laminar (intralaminar) screw fixation, anterior C1 to C2 transarticular screw fixation, C1 to 2 pedicle screw fixation, and posterior C1 to C2 transarticular screw fixation. Eight cadaveric cervical spines were tested intact and after dens fracture. Four different C1 to C2 screw fixation techniques were tested. Posterior transarticular and pedicle screw constructs were tested twice, once with supplemental sublaminar cables and once without cables. The specimens were tested in three modes of loading: flexion-extension, lateral bending, and axial rotation. All tests were performed in load and torque control. Pure bending moments of 2 nm were applied in flexion-extension and lateral bending, whereas a 1 nm moment was applied in axial rotation. Linear displacements were recorded from extensometers rigidly affixed to the C1 and C2 vertebrae. Linear displacements were reduced to angular displacements using trigonometry. Adding cable fixation results in a stiffer construct for posterior transarticular screws. The addition of cables did not affect the stiffness of C1 to C2 pedicle screw constructs. There were no significant differences in stiffness between anterior and posterior transarticular screw techniques, unless cable fixation was added to the posterior construct. All three posterior screw constructs with supplemental cable fixation provide equal stiffness with regard to flexion-extension and axial rotation. C1 lateral mass-C2 intralaminar screw fixation restored resistance to lateral bending but not to the same degree as the other screw fixation techniques. All four screw fixation techniques limit motion at the C1 to 2 articulation. The addition of cable fixation improves resistance to flexion and extension for posterior transarticular screw fixation.

Addendum to the User Manual for NASGRO Elastic-Plastic Fracture Mechanics Software Module

NASA Technical Reports Server (NTRS)

Gregg, M. Wayne (Technical Monitor); Chell, Graham; Gardner, Brian

2003-01-01

The elastic-plastic fracture mechanics modules in NASGRO have been enhanced by the addition of of the following: new J-integral solutions based on the reference stress method and finite element solutions; the extension of the critical crack and critical load modules for cracks with two degrees of freedom that tear and failure by ductile instability; the addition of a proof test analysis module that includes safe life analysis, calculates proof loads, and determines the flaw screening 1 capability for a given proof load; the addition of a tear-fatigue module for ductile materials that simultaneously tear and extend by fatigue; and a multiple cycle proof test module for estimating service reliability following a proof test.

Development, validity and reliability of a new pressure air biofeedback device (PAB) for measuring isometric extension strength of the lumbar spine.

PubMed

Pienaar, Andries W; Barnard, Justhinus G

2017-04-01

This study describes the development of a new portable muscle testing device, using air pressure as a biofeedback and strength testing tool. For this purpose, a pressure air biofeedback device (PAB ® ) was developed to measure and record the isometric extension strength of the lumbar multifidus muscle in asymptomatic and low back pain (LBP) persons. A total of 42 subjects (age 47.58 years, ±18.58) participated in this study. The validity of PAB ® was assessed by comparing a selected measure, air pressure force in millibar (mb), to a standard criterion; calibrated weights in kilograms (kg) during day-to-day tests. Furthermore, clinical trial-to-trial and day-to-day tests of maximum voluntary isometric contraction (MVIC) of L5 lumbar multifidus were done to compare air pressure force (mb) to electromyography (EMG) in microvolt (μV) and to measure the reliability of PAB ® . A highly significant relationship were found between air pressure output (mb) and calibrated weights (kg). In addition, Pearson correlation calculations showed a significant relationship between PAB ® force (mb) and EMG activity (μV) for all subjects (n = 42) examined, as well as for the asymptomatic group (n = 24). No relationship was detected for the LBP group (n = 18). In terms of lumbar extension strength, we found that asymptomatic subjects were significantly stronger than LBP subjects. The results of the PAB ® test differentiated between LBP and asymptomatic subject's lumbar isometric extension strength without any risk to the subjects and also indicate that the lumbar isometric extension test with the new PAB ® device is reliable and valid.

37 CFR 1.776 - Calculation of patent term extension for a food additive or color additive.

Code of Federal Regulations, 2010 CFR

2010-07-01

... extension for a food additive or color additive. 1.776 Section 1.776 Patents, Trademarks, and Copyrights... Calculation of patent term extension for a food additive or color additive. (a) If a determination is made pursuant to § 1.750 that a patent for a food additive or color additive is eligible for extension, the term...

37 CFR 1.776 - Calculation of patent term extension for a food additive or color additive.

Code of Federal Regulations, 2014 CFR

2014-07-01

... extension for a food additive or color additive. 1.776 Section 1.776 Patents, Trademarks, and Copyrights... Calculation of patent term extension for a food additive or color additive. (a) If a determination is made pursuant to § 1.750 that a patent for a food additive or color additive is eligible for extension, the term...

37 CFR 1.776 - Calculation of patent term extension for a food additive or color additive.

Code of Federal Regulations, 2011 CFR

2011-07-01

... extension for a food additive or color additive. 1.776 Section 1.776 Patents, Trademarks, and Copyrights... Calculation of patent term extension for a food additive or color additive. (a) If a determination is made pursuant to § 1.750 that a patent for a food additive or color additive is eligible for extension, the term...

37 CFR 1.776 - Calculation of patent term extension for a food additive or color additive.

Code of Federal Regulations, 2012 CFR

2012-07-01

... extension for a food additive or color additive. 1.776 Section 1.776 Patents, Trademarks, and Copyrights... Calculation of patent term extension for a food additive or color additive. (a) If a determination is made pursuant to § 1.750 that a patent for a food additive or color additive is eligible for extension, the term...

37 CFR 1.776 - Calculation of patent term extension for a food additive or color additive.

Code of Federal Regulations, 2013 CFR

2013-07-01

... extension for a food additive or color additive. 1.776 Section 1.776 Patents, Trademarks, and Copyrights... Calculation of patent term extension for a food additive or color additive. (a) If a determination is made pursuant to § 1.750 that a patent for a food additive or color additive is eligible for extension, the term...

Sensorimotor Exercises and Enhanced Trunk Function: A Randomized Controlled Trial.

PubMed

Mueller, Steffen; Engel, Tilman; Mueller, Juliane; Stoll, Josefine; Baur, Heiner; Mayer, Frank

2018-05-18

The aim of this study was to investigate the effect of a 6-week sensorimotor or resistance training on maximum trunk strength and response to sudden, high-intensity loading in athletes.Forty-three healthy, well-trained participants were randomized into sensorimotor (SMT; n=11), resistance training (RT; n=16) and control groups (CG; n=16). Treatment groups received either sensorimotor training (SMT) or resistance training (RT) for 6 weeks, 3 times a week. At baseline and after 6 weeks of intervention, participants' maximum isokinetic strength in trunk rotation and extension was tested (concentric/eccentric 30°/s). In addition, sudden, high-intensity trunk loading was assessed for eccentric extension and rotation, with additional perturbation. Peak torque [Nm] was calculated as the outcome.Interventions showed no significant difference for maximum strength in concentric and eccentric testing (p>0.05). For perturbation compensation, higher peak torque response following SMT (Extension: +24 Nm 95%CI±19 Nm; Rotation: +19 Nm 95%CI±13 Nm) and RT (Extension: +35 Nm 95%CI±16 Nm; Rotation: +5 Nm 95%CI±4 Nm) compared to CG (Extension: -4 Nm 95%CI±16 Nm; Rotation: -2 Nm 95%CI±4 Nm) was present (p<0.05).This study showed that isokinetic strength gains were small, but that significant improvements in high-intensity trunk loading response could be shown for both interventions. Therefore, depending on the individual's preference, therapists have two treatment options to enhance trunk function for back pain prevention. © Georg Thieme Verlag KG Stuttgart · New York.

Effects of silicon additions on oxidation and mechanical behavior of the nickel-base superalloy B-1900

NASA Technical Reports Server (NTRS)

Miner, R. V., Jr.; Lowell, C. E.

1975-01-01

Test specimens with nominal additions of Si were tested in oxidation, thermal fatigue, sulfidation, tension, and stress rupture, and were also extensively studied metallographically. Alloy B-1900 modified with 0.6- or 1.2-wt% Si exhibited oxidation resistance equivalent to that of aluminide-coated B-1900 during cyclic, high-gas-velocity oxidation tests. Resistances to thermal fatigue and sulfidation were improved by the Si additions, but were not superior to aluminide-coated B-1900. Stress-rupture tests at 1000 C of specimens given the standard heat treatment to simulate an aluminide coating cycle showed Si to be detrimental. However, application of another heat treatment increased the rupture life of the alloy with 0.6-wt% Si to that of the unmodified B-1900 given the standard heat treatment.

Summary of longitudinal stability and control parameters as determined from space shuttle Columbia flight test data

NASA Technical Reports Server (NTRS)

Suit, W. T.

1986-01-01

Extensive wind tunnel tests were conducted to establish the preflight aerodynamics of the Shuttle vehicle. This paper presents the longitudinal, short-period aerodynamics of the space shuttle Columbia as determined from flight test data. These flight-determined results are compared with the preflight predictions, and areas of agreement or disagreement are noted. In addition to the short-period aerodynamics, the pitch RCS effectiveness was determined.

Results of a First Generation Propellant Energy Source Module Testing: Non-Nuclear Testing of Fission System

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Godfroy, Tom; Houts, Mike; Dickens, Ricky; Dobson, Chris; Pederson, Kevin; Reid, Bob

1999-01-01

The use of resistance heaters to simulate heat from fission allows extensive development of fission systems to be performed in non-nuclear test facilities, saving time and money. Resistance heated tests on the Module Unfueled Thermal- hydraulic Test (MUTT) article has been performed at the Marshall Space Flight Center. This paper discusses the results of these experiments to date, and describes the additional testing that will be performed. Recommendations related to the design of testable space fission power and propulsion systems are made.

Results of a first generation least expensive approach to fission module tests: Non-nuclear testing of a fission system

NASA Astrophysics Data System (ADS)

van Dyke, Melissa; Godfroy, Tom; Houts, Mike; Dickens, Ricky; Dobson, Chris; Pederson, Kevin; Reid, Bob; Sena, J. Tom

2000-01-01

The use of resistance heaters to simulate heat from fission allows extensive development of fission systems to be performed in non-nuclear test facilities, saving time and money. Resistance heated tests on the Module Unfueled Thermal-hydraulic Test (MUTT) article has been performed at the Marshall Space Flight Center. This paper discusses the results of these experiments to date, and describes the additional testing that will be performed. Recommendations related to the design of testable space fission power and propulsion systems are made. .

Assessing the cost-effectiveness of a routine versus an extensive laboratory work-up in the diagnosis of anaemia in Dutch general practice.

PubMed

Kip, Michelle Ma; Schop, Annemarie; Stouten, Karlijn; Dekker, Soraya; Dinant, Geert-Jan; Koffijberg, Hendrik; Bindels, Patrick Je; IJzerman, Maarten J; Levin, Mark-David; Kusters, Ron

2018-01-01

Background Establishing the underlying cause of anaemia in general practice is a diagnostic challenge. Currently, general practitioners individually determine which laboratory tests to request (routine work-up) in order to diagnose the underlying cause. However, an extensive work-up (consisting of 14 tests) increases the proportion of patients correctly diagnosed. This study investigates the cost-effectiveness of this extensive work-up. Methods A decision-analytic model was developed, incorporating all societal costs from the moment a patient presents to a general practitioner with symptoms suggestive of anaemia (aged ≥ 50 years), until the patient was (correctly) diagnosed and treated in primary care, or referred to (and diagnosed in) secondary care. Model inputs were derived from an online survey among general practitioners, expert estimates and published data. The primary outcome measure was expressed as incremental cost per additional patient diagnosed with the correct underlying cause of anaemia in either work-up. Results The probability of general practitioners diagnosing the correct underlying cause increased from 49.6% (95% CI: 44.8% to 54.5%) in the routine work-up to 56.0% (95% CI: 51.2% to 60.8%) in the extensive work-up (i.e. +6.4% [95% CI: -0.6% to 13.1%]). Costs are expected to increase slightly from €842/patient (95% CI: €704 to €994) to €845/patient (95% CI: €711 to €994), i.e. +€3/patient (95% CI: €-35 to €40) in the extensive work-up, indicating incremental costs of €43 per additional patient correctly diagnosed. Conclusions The extensive laboratory work-up is more effective for diagnosing the underlying cause of anaemia by general practitioners, at a minimal increase in costs. As accompanying benefits in terms of quality of life and reduced productivity losses could not be captured in this analysis, the extensive work-up is likely cost-effective.

Variance change point detection for fractional Brownian motion based on the likelihood ratio test

NASA Astrophysics Data System (ADS)

Kucharczyk, Daniel; Wyłomańska, Agnieszka; Sikora, Grzegorz

2018-01-01

Fractional Brownian motion is one of the main stochastic processes used for describing the long-range dependence phenomenon for self-similar processes. It appears that for many real time series, characteristics of the data change significantly over time. Such behaviour one can observe in many applications, including physical and biological experiments. In this paper, we present a new technique for the critical change point detection for cases where the data under consideration are driven by fractional Brownian motion with a time-changed diffusion coefficient. The proposed methodology is based on the likelihood ratio approach and represents an extension of a similar methodology used for Brownian motion, the process with independent increments. Here, we also propose a statistical test for testing the significance of the estimated critical point. In addition to that, an extensive simulation study is provided to test the performance of the proposed method.

Density Deconvolution With EPI Splines

DTIC Science & Technology

2015-09-01

effects of various substances on test subjects [11], [12]. Whereas in geophysics, a shot may be fired into the ground, in pharmacokinetics, a signal is...be significant, including medicine, bioinformatics, chemistry, as- tronomy, and econometrics , as well as an extensive review of kernel based methods...demonstrate the effectiveness of our model in simulations motivated by test instances in [32]. We consider an additive measurement model scenario where

Results of 30 kWt Safe Affordable Fission Engine (SAFE-30) primary heat transport testing

NASA Astrophysics Data System (ADS)

Pedersen, Kevin; van Dyke, Melissa; Houts, Mike; Godfroy, Tom; Martin, James; Dickens, Ricky; Williams, Eric; Harper, Roger; Salvil, Pat; Reid, Bob

2001-02-01

The use of resistance heaters to simulate heat from fission allows extensive development of fission systems to be performed in non-nuclear test facilities, saving time and money. Resistance heated tests on the Safe Affordable Fission Engine-30 kilowatt (SAFE30) test article are being performed at the Marshall Space Flight Center. This paper discusses the results of these experiments to date, and describes the additional testing that will be performed. Recommendations related to the design of testable space fission power and propulsion systems are made. .

Partnership to Improve Nutrient Efficiency

EPA Science Inventory

PINE began in 2013 by working with OSU Extension and producers to locate and test existing 1990s lysimeters in Benton, Linn and Lane counties. The team identified additional producers to install Prenart lysimeters at a total of 15 sites. Producers allow for soil and water samplin...

Prevention of distal extension cantilever fracture in mandibular overdentures.

PubMed

Quirynen, Thomas; Quirynen, Marc; Duyck, Joke

2015-09-01

Fractures of distal bar extensions, supporting a mandibular overdenture, do occur with significant functional and economic consequences for the patient. This study therefore aims to evaluate the effect of different bar cross-sectional shapes and surfaces, bar extension lengths and the placement of a support rib under the distal bar extension on fracture resistance. The 2nd moment area and static strength were calculated for 11 frequently used bar designs using finite element analysis (FEA). For two specific designs (Ackermann round Ø 1.8mm and Dolder-Y macro, the former with and without a support rib) additional physical static and fatigue strength tests were included. The FEA static strength data corresponded well to the 2nd moment area (a similar ranking when maximum allowed force was considered). The application of a rib support (Ackermann Ø 1.8mm) and limitations of the bar extension length (6mm for the Ackermann Ø 1.8mm, 8mm for the Dolder-Y macro) allowed the bars to exceed 5 × 10(6) cycles of 120 and 250N, respectively, before fracture. The region of highest stresses in FEA corresponded well with the locations of the fractures observed in static- and fatigue-testing. With some simple guidelines/modifications, the number of bar extension fractures can be reduced significantly. This study focusses on distal bar extensions which improve the positioning of an implant supported overdenture. By combining laboratory testing and finite element simulations we aim to: (1) explain why fractures occur (dependent on physical characteristics of the bar), and (2) give clinical guidelines on how to prevent such fractures. Copyright © 2015 Elsevier Ltd. All rights reserved.

Butyl rubber O-ring seals: Revision of test procedures for stockpile materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Domeier, L.A.; Wagter, K.R.

1996-12-01

Extensive testing showed little correlation between test slab and O-ring performance. New procedures, comparable to those used with the traditional test slabs, were defined for hardness, compression set, and tensile property testing on sacrificial O-ring specimens. Changes in target performance values were made as needed and were, in one case, tightened to reflect the O-ring performance data. An additional study was carried out on O-ring and slab performance vs cure cycle and showed little sensitivity of material performance to large changes in curing time. Aging and spectra of certain materials indicated that two sets of test slabs from current vendormore » were accidently made from EPDM rather than butyl rubber. Random testing found no O-rings made from EPDM. As a result, and additional spectroscope test will be added to the product acceptance procedures to verify the type of rubber compound used.« less

Performance analysis and an assessment of operational issues of Ya-21U

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paramonov, D.V.; El-Genk, M.S.

1996-03-01

Extensive testing of the Soviet made TOPAZ-II space nuclear power system unit designated {open_quote}{open_quote}Ya-21U{close_quote}{close_quote} was conducted both in the USSR (1989{endash}1990) and in the US (August 1993 to March 1995). The unit underwent a total of 15 tests for a cumulative test/operation time of almost 8000 hours. These tests included steady-state operation at different power levels, fast startups and power optimizations. Leaks were detected in some of the Thermionic Fuel Elements (TFEs) after the first test in the US. These leaks that facilitated air incursion into the interelectrode gap caused operational changes in both electric power and conversion efficiency andmore » changed the optimum cesium pressure and load voltage. Additional changes in operational performance were detected following shock and vibration tests performed in August 1994. Test data was examined and analyzed to assess the performance of not only individual TFEs, and also the whole Ya-21U unit, and identify causes for measured operational performance changes; most probable causes were identified and discussed. The Ya-21U unit remained operational throughout extensive testing for 8000 hours at conditions far exceeding the design limits of the TOPAZ-II system. No single TFE was damaged during testing and measured operational performance changes were uniform among working section TFEs. In addition to providing a unique knowledge base for future development and operation of thermionic power systems, the test results testify to the reliability and ruggedness of the TOPAZ-II system design. {copyright} {ital 1996 American Institute of Physics.}« less

Isokinetic Extension Strength Is Associated With Single-Leg Vertical Jump Height.

PubMed

Fischer, Felix; Blank, Cornelia; Dünnwald, Tobias; Gföller, Peter; Herbst, Elmar; Hoser, Christian; Fink, Christian

2017-11-01

Isokinetic strength testing is an important tool in the evaluation of the physical capacities of athletes as well as for decision making regarding return to sports after anterior cruciate ligament (ACL) reconstruction in both athletes and the lay population. However, isokinetic testing is time consuming and requires special testing equipment. A single-jump test, regardless of leg dominance, may provide information regarding knee extension strength through the use of correlation analysis of jump height and peak torque of isokinetic muscle strength. Cross-sectional study; Level of evidence, 3. A total of 169 patients who underwent ACL reconstruction were included in this study. Isokinetic testing was performed on the injured and noninjured legs. Additionally, a single-leg countermovement jump was performed to assess jump height using a jump accelerometer sensor. Extension strength values were used to assess the association between isokinetic muscle strength and jump height. The sample consisted of 60 female (mean age, 20.8 ± 8.3 years; mean weight, 61.7 ± 6.5 kg; mean height, 167.7 ± 5.3 cm) and 109 male (mean age, 23.2 ± 7.7 years; mean weight, 74.6 ± 10.2 kg; mean height, 179.9 ± 6.9 cm) patients. Bivariate correlation analysis showed an association ( r = 0.56, P < .001) between jump height and isokinetic extension strength on the noninvolved side as well as an association ( r = 0.52, P < .001) for the involved side. Regression analysis showed that in addition to jump height (beta = 0.49, P < .001), sex (beta = -0.17, P = .008) and body mass index (beta = 0.37, P < .001) affected isokinetic strength. The final model explained 51.1% of the variance in isokinetic muscle strength, with jump height having the strongest impact (beta = 0.49, P < .001) and explaining 31.5% of the variance. Initial analysis showed a strong association between isokinetic strength and jump height. The study population encompassed various backgrounds, skill levels, and activity profiles, which might have affected the outcome. Even after controlling for age and sex, isokinetic strength was still moderately associated with jump height. Therefore, the jump technique and type of sport should be considered in future research.

Acoustic Measurements of a Large Civil Transport Main Landing Gear Model

NASA Technical Reports Server (NTRS)

Ravetta, Patricio A.; Khorrami, Mehdi R.; Burdisso, Ricardo A.; Wisda, David M.

2016-01-01

Microphone phased array acoustic measurements of a 26 percent-scale, Boeing 777-200 main landing gear model with and without noise reduction fairings installed were obtained in the anechoic configuration of the Virginia Tech Stability Tunnel. Data were acquired at Mach numbers of 0.12, 0.15, and 0.17 with the latter speed used as the nominal test condition. The fully and partially dressed gear with the truck angle set at 13 degrees toe-up landing configuration were the two most extensively tested configurations, serving as the baselines for comparison purposes. Acoustic measurements were also acquired for the same two baseline configurations with the truck angle set at 0 degrees. In addition, a previously tested noise reducing, toboggan-shaped fairing was re-evaluated extensively to address some of the lingering questions regarding the extent of acoustic benefit achievable with this device. The integrated spectra generated from the acoustic source maps reconfirm, in general terms, the previously reported noise reduction performance of the toboggan fairing as installed on an isolated gear. With the recent improvements to the Virginia Tech tunnel acoustic quality and microphone array capabilities, the present measurements provide an additional, higher quality database to the acoustic information available for this gear model.

High-Melt Carbon-Carbon Coating for Nozzle Extensions

NASA Technical Reports Server (NTRS)

Thompson, James

2015-01-01

Carbon-Carbon Advanced Technologies, Inc. (C-CAT), has developed a high-melt coating for use in nozzle extensions in next-generation spacecraft. The coating is composed primarily of carbon-carbon, a carbon-fiber and carbon-matrix composite material that has gained a spaceworthy reputation due to its ability to withstand ultrahigh temperatures. C-CAT's high-melt coating embeds hafnium carbide (HfC) and zirconium diboride (ZrB2) within the outer layers of a carbon-carbon structure. The coating demonstrated enhanced high-temperature durability and suffered no erosion during a test in NASA's Arc Jet Complex. (Test parameters: stagnation heat flux=198 BTD/sq ft-sec; pressure=.265 atm; temperature=3,100 F; four cycles totaling 28 minutes) In Phase I of the project, C-CAT successfully demonstrated large-scale manufacturability with a 40-inch cylinder representing the end of a nozzle extension and a 16-inch flanged cylinder representing the attach flange of a nozzle extension. These demonstrators were manufactured without spalling or delaminations. In Phase II, C-CAT worked with engine designers to develop a nozzle extension stub skirt interfaced with an Aerojet Rocketdyne RL10 engine. All objectives for Phase II were successfully met. Additional nonengine applications for the coating include thermal protection systems (TPS) for next-generation spacecraft and hypersonic aircraft.

Extensions of Rasch's Multiplicative Poisson Model.

ERIC Educational Resources Information Center

Jansen, Margo G. H.; van Duijn, Marijtje A. J.

1992-01-01

A model developed by G. Rasch that assumes scores on some attainment tests can be realizations of a Poisson process is explained and expanded by assuming a prior distribution, with fixed but unknown parameters, for the subject parameters. How additional between-subject and within-subject factors can be incorporated is discussed. (SLD)

High gantry for lifting and handling

NASA Technical Reports Server (NTRS)

Kerley, J. J., Jr.; Tereniak, W. T.

1977-01-01

Standard gantry has been inexpensively modified with standard pipes to allow lifting of heavy loads to distances between 14 and 30 ft. Addition of air mounts permits extensive and sensitive equipment to be moved smoothly and safely over smooth or moderately rough surfaces. Unit has been tested at 6000 pounds without yielding.

76 FR 27335 - Laboratory Animal Welfare: Proposed Adoption and Implementation of the Eighth Edition of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

..., experimentation, biological testing, or related purposes) involving live vertebrate animals. The eighth edition of... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Laboratory Animal Welfare... Animals AGENCY: National Institutes of Health, HHS. ACTION: Notice of Additional Extension of Comment...

Wind Tunnel Testing of a 120th Scale Large Civil Tilt-Rotor Model in Airplane and Helicopter Modes

NASA Technical Reports Server (NTRS)

Theodore, Colin R.; Willink, Gina C.; Russell, Carl R.; Amy, Alexander R.; Pete, Ashley E.

2014-01-01

In April 2012 and October 2013, NASA and the U.S. Army jointly conducted a wind tunnel test program examining two notional large tilt rotor designs: NASA's Large Civil Tilt Rotor and the Army's High Efficiency Tilt Rotor. The approximately 6%-scale airframe models (unpowered) were tested without rotors in the U.S. Army 7- by 10-foot wind tunnel at NASA Ames Research Center. Measurements of all six forces and moments acting on the airframe were taken using the wind tunnel scale system. In addition to force and moment measurements, flow visualization using tufts, infrared thermography and oil flow were used to identify flow trajectories, boundary layer transition and areas of flow separation. The purpose of this test was to collect data for the validation of computational fluid dynamics tools, for the development of flight dynamics simulation models, and to validate performance predictions made during conceptual design. This paper focuses on the results for the Large Civil Tilt Rotor model in an airplane mode configuration up to 200 knots of wind tunnel speed. Results are presented with the full airframe model with various wing tip and nacelle configurations, and for a wing-only case also with various wing tip and nacelle configurations. Key results show that the addition of a wing extension outboard of the nacelles produces a significant increase in the lift-to-drag ratio, and interestingly decreases the drag compared to the case where the wing extension is not present. The drag decrease is likely due to complex aerodynamic interactions between the nacelle and wing extension that results in a significant drag benefit.

Asteroids as Calibration Standards in the Thermal Infrared -- Applications and Results from ISO

NASA Astrophysics Data System (ADS)

Müller, T. G.; Lagerros, J. S. V.

Asteroids have been used extensively as calibration sources for ISO. We summarise the asteroid observational parameters in the thermal infrared and explain the important modelling aspects. Ten selected asteroids were extensively used for the absolute photometric calibration of ISOPHOT in the far-IR. Additionally, the point-like and bright asteroids turned out to be of great interest for many technical tests and calibration aspects. They have been used for testing the calibration for SWS and LWS, the validation of relative spectral response functions of different bands, for colour correction and filter leak tests. Currently, there is a strong emphasis on ISO cross-calibration, where the asteroids contribute in many fields. Well known asteroids have also been seen serendipitously in the CAM Parallel Mode and the PHT Serendipity Mode, allowing for validation and improvement of the photometric calibration of these special observing modes.

Maximum step length: relationships to age and knee and hip extensor capacities.

PubMed

Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B

2007-07-01

Maximum Step Length may be used to identify older adults at increased risk for falls. Since leg muscle weakness is a risk factor for falls, we tested the hypotheses that maximum knee and hip extension speed, strength, and power capacities would significantly correlate with Maximum Step Length and also that the "step out and back" Maximum Step Length [Medell, J.L., Alexander, N.B., 2000. A clinical measure of maximal and rapid stepping in older women. J. Gerontol. A Biol. Sci. Med. Sci. 55, M429-M433.] would also correlate with the Maximum Step Length of its two sub-tasks: stepping "out only" and stepping "back only". These sub-tasks will be referred to as versions of Maximum Step Length. Unimpaired younger (N=11, age=24[3]years) and older (N=10, age=73[5]years) women performed the above three versions of Maximum Step Length. Knee and hip extension speed, strength, and power capacities were determined on a separate day and regressed on Maximum Step Length and age group. Version and practice effects were quantified and subjective impressions of test difficulty recorded. Hypotheses were tested using linear regressions, analysis of variance, and Fisher's exact test. Maximum Step Length explained 6-22% additional variance in knee and hip extension speed, strength, and power capacities after controlling for age group. Within- and between-block and test-retest correlation values were high (>0.9) for all test versions. Shorter Maximum Step Lengths are associated with reduced knee and hip extension speed, strength, and power capacities after controlling for age. A single out-and-back step of maximal length is a feasible, rapid screening measure that may provide insight into underlying functional impairment, regardless of age.

Criterion-Related Validity of Sit-and-Reach Tests for Estimating Hamstring and Lumbar Extensibility: a Meta-Analysis

PubMed Central

Mayorga-Vega, Daniel; Merino-Marban, Rafael; Viciana, Jesús

2014-01-01

The main purpose of the present meta-analysis was to examine the scientific literature on the criterion-related validity of sit-and-reach tests for estimating hamstring and lumbar extensibility. For this purpose relevant studies were searched from seven electronic databases dated up through December 2012. Primary outcomes of criterion-related validity were Pearson´s zero-order correlation coefficients (r) between sit-and-reach tests and hamstrings and/or lumbar extensibility criterion measures. Then, from the included studies, the Hunter- Schmidt´s psychometric meta-analysis approach was conducted to estimate population criterion- related validity of sit-and-reach tests. Firstly, the corrected correlation mean (rp), unaffected by statistical artefacts (i.e., sampling error and measurement error), was calculated separately for each sit-and-reach test. Subsequently, the three potential moderator variables (sex of participants, age of participants, and level of hamstring extensibility) were examined by a partially hierarchical analysis. Of the 34 studies included in the present meta-analysis, 99 correlations values across eight sit-and-reach tests and 51 across seven sit-and-reach tests were retrieved for hamstring and lumbar extensibility, respectively. The overall results showed that all sit-and-reach tests had a moderate mean criterion-related validity for estimating hamstring extensibility (rp = 0.46-0.67), but they had a low mean for estimating lumbar extensibility (rp = 0. 16-0.35). Generally, females, adults and participants with high levels of hamstring extensibility tended to have greater mean values of criterion-related validity for estimating hamstring extensibility. When the use of angular tests is limited such as in a school setting or in large scale studies, scientists and practitioners could use the sit-and-reach tests as a useful alternative for hamstring extensibility estimation, but not for estimating lumbar extensibility. Key Points Overall sit-and-reach tests have a moderate mean criterion-related validity for estimating hamstring extensibility, but they have a low mean validity for estimating lumbar extensibility. Among all the sit-and-reach test protocols, the Classic sit-and-reach test seems to be the best option to estimate hamstring extensibility. End scores (e.g., the Classic sit-and-reach test) are a better indicator of hamstring extensibility than the modifications that incorporate fingers-to-box distance (e.g., the Modified sit-and-reach test). When angular tests such as straight leg raise or knee extension tests cannot be used, sit-and-reach tests seem to be a useful field test alternative to estimate hamstring extensibility, but not to estimate lumbar extensibility. PMID:24570599

Extension of Ostwald Ripening Theory

NASA Technical Reports Server (NTRS)

Baird, J.; Naumann, R.

1985-01-01

The objective is to develop models based on the mean field approximation of Ostwald ripening to describe the growth of second phase droplets or crystallites. The models will include time variations in nucleation rate, control of saturation through addition of solute, precipitating agents, changes in temperature, and various surface kinetic effects. Numerical integration schemes have been developed and tested against the asymptotic solution of Liftshitz, Slyozov and Wagner (LSW). A second attractor (in addition to the LSW distribution) has been found and, contrary to the LSW theory, the final distribution is dependent on the initial distribution. A series of microgravity experiments is being planned to test this and other results from this work.

Appendices to the user's manual for a computer program for the emulation/simulation of a space station environmental control and life support system

NASA Technical Reports Server (NTRS)

Yanosy, James L.

1988-01-01

A user's Manual for the Emulation Simulation Computer Model was published previously. The model consisted of a detailed model (emulation) of a SAWD CO2 removal subsystem which operated with much less detailed (simulation) models of a cabin, crew, and condensing and sensible heat exchangers. The purpose was to explore the utility of such an emulation/simulation combination in the design, development, and test of a piece of ARS hardware - SAWD. Extensions to this original effort are presented. The first extension is an update of the model to reflect changes in the SAWD control logic which resulted from the test. In addition, slight changes were also made to the SAWD model to permit restarting and to improve the iteration technique. The second extension is the development of simulation models for more pieces of air and water processing equipment. Models are presented for: EDC, Molecular Sieve, Bosch, Sabatier, a new condensing heat exchanger, SPE, SFWES, Catalytic Oxidizer, and multifiltration. The third extension is to create two system simulations using these models. The first system presented consists of one air and one water processing system, the second a potential Space Station air revitalization system.

Black Box Testing: Experiments with Runway Incursion Advisory Alerting System

NASA Technical Reports Server (NTRS)

Mukkamala, Ravi

2005-01-01

This report summarizes our research findings on the Black box testing of Runway Incursion Advisory Alerting System (RIAAS) and Runway Safety Monitor (RSM) system. Developing automated testing software for such systems has been a problem because of the extensive information that has to be processed. Customized software solutions have been proposed. However, they are time consuming to develop. Here, we present a less expensive, and a more general test platform that is capable of performing complete black box testing. The technique is based on the classification of the anomalies that arise during Monte Carlo simulations. In addition, we also discuss a generalized testing tool (prototype) that we have developed.

76 FR 60829 - Information Collection Being Reviewed by the Federal Communications Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

... Authorization-Verification (Retention of Records). Form No.: N/A. Type of Review: Extension of a currently... verification, the responsible party, as shown in 47 CFR 2.909 shall maintain the records listed as follows: (1... laboratory, company, or individual performing the verification testing. The Commission may request additional...

Flexible fire retardant polyisocyanate modified neoprene foam. [for thermal protective devices

NASA Technical Reports Server (NTRS)

Parker, J. A.; Riccitiello, S. R. (Inventor)

1973-01-01

Lightweight, fire resistant foams have been developed through the modification of conventional neoprene-isocyanate foams by the addition of an alkyl halide polymer. Extensive tests have shown that the modified/neoprene-isocyanate foams are much superior in heat protection properties than the foams heretofore employed both for ballistic and ablative purposes.

Simplified analysis of a generalized bias test for fabrics with two families of inextensible fibres

NASA Astrophysics Data System (ADS)

Cuomo, M.; dell'Isola, F.; Greco, L.

2016-06-01

Two tests for woven fabrics with orthogonal fibres are examined using simplified kinematic assumptions. The aim is to analyse how different constitutive assumptions may affect the response of the specimen. The fibres are considered inextensible, and the kinematics of 2D continua with inextensible chords due to Rivlin is adopted. In addition to two forms of strain energy depending on the shear deformation, also two forms of energy depending on the gradient of shear are examined. It is shown that this energy can account for the bending of the fibres. In addition to the standard bias extension test, a modified test has been examined, in which the head of the specimen is rotated rather than translated. In this case more bending occurs, so that the results of the simulation carried out with the different energy models adopted differ more that what has been found for the BE test.

Predicting the Extension of Biomedical Ontologies

PubMed Central

Pesquita, Catia; Couto, Francisco M.

2012-01-01

Developing and extending a biomedical ontology is a very demanding task that can never be considered complete given our ever-evolving understanding of the life sciences. Extension in particular can benefit from the automation of some of its steps, thus releasing experts to focus on harder tasks. Here we present a strategy to support the automation of change capturing within ontology extension where the need for new concepts or relations is identified. Our strategy is based on predicting areas of an ontology that will undergo extension in a future version by applying supervised learning over features of previous ontology versions. We used the Gene Ontology as our test bed and obtained encouraging results with average f-measure reaching 0.79 for a subset of biological process terms. Our strategy was also able to outperform state of the art change capturing methods. In addition we have identified several issues concerning prediction of ontology evolution, and have delineated a general framework for ontology extension prediction. Our strategy can be applied to any biomedical ontology with versioning, to help focus either manual or semi-automated extension methods on areas of the ontology that need extension. PMID:23028267

WSTF Propulsion and Pyrotechnics Corrective Action Test Program Status-2000

NASA Technical Reports Server (NTRS)

Saulsberry, R.; Ramirez, J.; Julien, H. L.; Hart, M.; Smith, W.; Bement, L.; Meagher, N. E.

2000-01-01

Extensive propulsion and pyrotechnic testing has been in progress at the NASA Johnson Space Center White Sands Test Facility (WSTF) since 1995. This started with the Mars Observer Propulsion and Pyrotechnics Corrective Action Test Program (MOCATP). The MOCATP has concluded, but extensive pyrovalve testing and research and development has continued at WSTF. The capability to accurately analyze and measure pyrovalve combustion product blow-by, evaluate propellant explosions initiated by blow-by, and characterize pyrovalve operation continues to be used and improved. This paper contains an overview of testing since MOCATP inception, but focuses on accomplishments since the status was last reported at the 35th Joint Propulsion Conference, June, 1999. This new activity includes evaluation of 3/8 inch Conax pyrovalves; development and testing of advanced pyrovalve technologies; investigation of nondestructive evaluation techniques to inspect pyrotechnically induced hydrazine explosions both through testing and modeling. Data from this collection of projects are now being formatted into a pyrovalve applications and testing handbook and consensus standard to benefit pyrovalve users and spacecraft designers. The handbook is briefly described here and in more detail in a separate paper. To increase project benefit, pyrovalve manufacturers are encouraged to provide additional valves for testing and consideration, and feedback is encouraged in all aspects of the pyrotechnic projects.

Effectiveness of acute in-hospital physiotherapy with knee-extension strength training in reducing strength deficits in patients with a hip fracture: A randomised controlled trial

PubMed Central

2017-01-01

Question Is acute in-hospital physiotherapy with additional progressive knee-extension strength training (ST) of the fractured limb more effective in reducing knee-extension strength deficit at follow-up compared to physiotherapy without strength training in patients with a hip fracture? Design Assessor blinded, randomised controlled trial with intention-to-treat analysis. Participants 90 patients with a hip fracture admitted to an acute orthopaedic Hip Fracture Unit at a university hospital between October 2013 and May 2015. Intervention Daily physiotherapy with or without progressive knee-extension strength training (10RM), 3 x 10 repetitions, of the fractured limb using ankle weight cuffs conducted by ward physical therapists during hospital stay. Outcome measures Primary outcome was the change in maximal isometric knee-extension strength in the fractured limb in percentage of the non-fractured limb from inclusion to postoperative day 10 or discharge (follow-up). Secondary outcome was Timed Up and Go test measured early after surgery and at follow-up. Results In the intention-to-treat analysis of between-group differences, the primary outcome improved 8.1% (95% CI -2.3; 18.4) by additional strength training from baseline to follow-up. In the per-protocol analysis of non-missing data, significant between-group improvements by 10.5% (95% CI 0.3; 20.7) were found in favour of additional ST. No significant between-group differences were found in any secondary outcome. Conclusion Physiotherapy with addition of 5 sessions of ST yielded no additional improvements compared to physiotherapy without strength training in reducing the knee-extension strength deficit at follow-up in patients with a hip fracture. It is debatable whether larger improvements than the observed 8–10% can be expected given that only five exercise sessions, on average, were completed. In fragile patients with a hip fracture in the acute phase, where the ability to participate in functional exercise is compromised, we still consider early strength training a possibility to improve outcomes of clinical importance, given the results of the per-protocol analysis. The present data provides an important basis and call for future investigations including longer term interventions. Trial registration Clinicaltrials.gov NCT00848913 PMID:28662153

Hierarchical Testing with Automated Document Generation for Amanzi, ASCEM's Subsurface Flow and Reactive Transport Simulator

NASA Astrophysics Data System (ADS)

Moulton, J. D.; Steefel, C. I.; Yabusaki, S.; Castleton, K.; Scheibe, T. D.; Keating, E. H.; Freedman, V. L.

2013-12-01

The Advanced Simulation Capabililty for Environmental Management (ASCEM) program is developing an approach and open-source tool suite for standardized risk and performance assessments at legacy nuclear waste sites. These assessments use a graded and iterative approach, beginning with simplified highly abstracted models, and adding geometric and geologic complexity as understanding is gained. To build confidence in this assessment capability, extensive testing of the underlying tools is needed. Since the tools themselves, such as the subsurface flow and reactive-transport simulator, Amanzi, are under active development, testing must be both hierarchical and highly automated. In this presentation we show how we have met these requirements, by leveraging the python-based open-source documentation system called Sphinx with several other open-source tools. Sphinx builds on the reStructured text tool docutils, with important extensions that include high-quality formatting of equations, and integrated plotting through matplotlib. This allows the documentation, as well as the input files for tests, benchmark and tutorial problems, to be maintained with the source code under a version control system. In addition, it enables developers to build documentation in several different formats (e.g., html and pdf) from a single source. We will highlight these features, and discuss important benefits of this approach for Amanzi. In addition, we'll show that some of ASCEM's other tools, such as the sampling provided by the Uncertainty Quantification toolset, are naturally leveraged to enable more comprehensive testing. Finally, we will highlight the integration of this hiearchical testing and documentation framework with our build system and tools (CMake, CTest, and CDash).

Extensive validation of the pain disability index in 3 groups of patients with musculoskeletal pain.

PubMed

Soer, Remko; Köke, Albère J A; Vroomen, Patrick C A J; Stegeman, Patrick; Smeets, Rob J E M; Coppes, Maarten H; Reneman, Michiel F

2013-04-20

A cross-sectional study design was performed. To validate the pain disability index (PDI) extensively in 3 groups of patients with musculoskeletal pain. The PDI is a widely used and studied instrument for disability related to various pain syndromes, although there is conflicting evidence concerning factor structure, test-retest reliability, and missing items. Additionally, an official translation of the Dutch language version has never been performed. For reliability, internal consistency, factor structure, test-retest reliability and measurement error were calculated. Validity was tested with hypothesized correlations with pain intensity, kinesiophobia, Rand-36 subscales, Depression, Roland-Morris Disability Questionnaire, Quality of Life, and Work Status. Structural validity was tested with independent backward translation and approval from the original authors. One hundred seventy-eight patients with acute back pain, 425 patients with chronic low back pain and 365 with widespread pain were included. Internal consistency of the PDI was good. One factor was identified with factor analyses. Test-retest reliability was good for the PDI (intraclass correlation coefficient, 0.76). Standard error of measurement was 6.5 points and smallest detectable change was 17.9 points. Little correlations between the PDI were observed with kinesiophobia and depression, fair correlations with pain intensity, work status, and vitality and moderate correlations with the Rand-36 subscales and the Roland-Morris Disability Questionnaire. The PDI-Dutch language version is internally consistent as a 1-factor structure, and test-retest reliable. Missing items seem high in sexual and professional items. Using the PDI as a 2-factor questionnaire has no additional value and is unreliable.

Testing a Culture-Specific Extension of Objectification Theory regarding African American Women's Body Image

ERIC Educational Resources Information Center

Buchanan, Taneisha S.; Fischer, Ann R.; Tokar, David M.; Yoder, Janice D.

2008-01-01

Objectification theory has emphasized objectification in terms of body shape and size. African American women may expect to be evaluated on additional physical attributes such as skin tone. Therefore, we extended previous research on objectification theory by adding separate measures of skin-tone concerns in a survey of 117 African American women.…

75 FR 17414 - Determination of Regulatory Review Period for Purposes of Patent Extension; TOVIAZ

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

... Restoration Act of 1984 (Public Law 98-417) and the Generic Animal Drug and Patent Term Restoration Act... as the patented item (human drug product, animal drug product, medical device, food additive, or... approval phase. For human drug products, the testing phase begins when the exemption to permit the clinical...

75 FR 18213 - Determination of Regulatory Review Period for Purposes of Patent Extension; MOZOBIL

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... Restoration Act of 1984 (Public Law 98-417) and the Generic Animal Drug and Patent Term Restoration Act... as the patented item (human drug product, animal drug product, medical device, food additive, or... approval phase. For human drug products, the testing phase begins when the exemption to permit the clinical...

75 FR 19406 - Determination of Regulatory Review Period for Purposes of Patent Extension; AFINITOR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... Restoration Act of 1984 (Public Law 98-417) and the Generic Animal Drug and Patent Term Restoration Act... as the patented item (human drug product, animal drug product, medical device, food additive, or... approval phase. For human drug products, the testing phase begins when the exemption to permit the clinical...

75 FR 17415 - Determination of Regulatory Review Period for Purposes of Patent Extension; FANAPT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

... Restoration Act of 1984 (Public Law 98-417) and the Generic Animal Drug and Patent Term Restoration Act... as the patented item (human drug product, animal drug product, medical device, food additive, or... approval phase. For human drug products, the testing phase begins when the exemption to permit the clinical...

Isokinetic Extension Strength Is Associated With Single-Leg Vertical Jump Height

PubMed Central

Fischer, Felix; Blank, Cornelia; Dünnwald, Tobias; Gföller, Peter; Herbst, Elmar; Hoser, Christian; Fink, Christian

2017-01-01

Background: Isokinetic strength testing is an important tool in the evaluation of the physical capacities of athletes as well as for decision making regarding return to sports after anterior cruciate ligament (ACL) reconstruction in both athletes and the lay population. However, isokinetic testing is time consuming and requires special testing equipment. Hypothesis: A single-jump test, regardless of leg dominance, may provide information regarding knee extension strength through the use of correlation analysis of jump height and peak torque of isokinetic muscle strength. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 169 patients who underwent ACL reconstruction were included in this study. Isokinetic testing was performed on the injured and noninjured legs. Additionally, a single-leg countermovement jump was performed to assess jump height using a jump accelerometer sensor. Extension strength values were used to assess the association between isokinetic muscle strength and jump height. Results: The sample consisted of 60 female (mean age, 20.8 ± 8.3 years; mean weight, 61.7 ± 6.5 kg; mean height, 167.7 ± 5.3 cm) and 109 male (mean age, 23.2 ± 7.7 years; mean weight, 74.6 ± 10.2 kg; mean height, 179.9 ± 6.9 cm) patients. Bivariate correlation analysis showed an association (r = 0.56, P < .001) between jump height and isokinetic extension strength on the noninvolved side as well as an association (r = 0.52, P < .001) for the involved side. Regression analysis showed that in addition to jump height (beta = 0.49, P < .001), sex (beta = –0.17, P = .008) and body mass index (beta = 0.37, P < .001) affected isokinetic strength. The final model explained 51.1% of the variance in isokinetic muscle strength, with jump height having the strongest impact (beta = 0.49, P < .001) and explaining 31.5% of the variance. Conclusion: Initial analysis showed a strong association between isokinetic strength and jump height. The study population encompassed various backgrounds, skill levels, and activity profiles, which might have affected the outcome. Even after controlling for age and sex, isokinetic strength was still moderately associated with jump height. Therefore, the jump technique and type of sport should be considered in future research. PMID:29147670

Preliminary design and development of a reflectance spectrometer instrument

NASA Technical Reports Server (NTRS)

Mccord, T. B.

1979-01-01

An improved design for the reflectance spectrometer is described to be used on various terrestrial body missions. These improvements were made on the original Lunar Polar Orbiter design. These include a larger entrance mirror, rectangular aperture, multiple optical beams, spatial resolution, and a bandwidth extension to 5 microns. In addition, detailed electronic designs were produced for a charge amplifier and an amplifier/demodulator/integrator. Design of a microprocessor driven test system was begun. Laboratory tests were performed on a tuning fork chopper.

Risk assessment by percolation leaching tests of extensive green roofs with fine fraction of mixed recycled aggregates from construction and demolition waste.

PubMed

López-Uceda, Antonio; Galvín, Adela P; Ayuso, Jesús; Jiménez, José Ramón; Vanwalleghem, Tom; Peña, Adolfo

2018-03-19

Extensive green roofs are urban construction systems that provide thermal regulation and sound proofing for the buildings involved, in addition to providing an urban heat island mitigation or water retention. On the other hand, policies towards reduction of energy consumption, a circular economy and sustainability are core in the European Union. Motivated by this, an experimental study was carried out to evaluate the environmental risk assessment according to release levels of polluting elements on leachates of different green roof substrate mixtures based on recycled aggregates from construction and demolition waste through (i) the performance in laboratory of two procedures: compliance and percolation tests and (ii) an upscaled experimental leaching test for long-term on-site prediction. Four plots were built on a building roof and covered with autochthonous Mediterranean plants in Córdoba, South of Spain. As growing substrate, four mixtures were used of a commercial growing substrate with different proportions of a fine mixed recycled aggregate ranging from 0 to 75% by volume. The results show that these mixtures were classified as non-hazardous materials according to legal limits of the Landfill Directive 2003/33/CE. The release levels registered in extensive green roofs were lower compared to the laboratory test data. This shows how laboratory conditions can overestimate the potential pollutant effect of these materials compared to actual conditions.

A simulation study of spine biofidelity in the hybrid-III 6-year-old ATD.

PubMed

Wu, Jun; Cao, Libo; Reed, Matthew P; Hu, Jingwen

2013-01-01

Because of the lack of pediatric biomechanical data, Hybrid-III (HIII) child anthropomorphic test devices (ATDs) are essentially scaled from the mid-size male ATD based on the geometric considerations. These ATDs inherit a rigid thoracic spine from the adult HIII ATDs, which has been criticized as unrealistic. Therefore, the objective of this study was to explore possible design modifications for improving the spine biofidelity of the HIII 6-year-old ATD. A previously developed and validated HIII 6-year-old MADYMO ATD model was used as the baseline model to investigate the effects of design modifications on the spine biofidelity of the current ATD. Several sets of child volunteer and cadaver test data were considered as the design targets, including child volunteer low-speed crash test data, pediatric cadaver cervical spine tensile test data, and child cadaver crash test data. ATD design modifications include adding an additional joint to the thoracic spine region and changing the joint characteristics at the cervical and lumbar spine regions. Optimization techniques were used to match simulation results to each set of test results. The results indicate that the translational characteristics of the cervical and lumbar spine in the current child ATD need to be reduced to achieve realistic spine flexibility. Adding an additional joint at the thoracic spine region with degree of freedom in both flexion/extension and tension would significantly improve the ATD biofidelity in terms of predicting the overall spine curvature and head excursion in frontal crashes. Future ATD spine modification should focus on reducing the neck and lumbar tension stiffness and adding additional flexibility both in flexion/extension and tension at the thoracic spine region. The child ATD model developed in this study can be used as an important tool to improve child ATD biofidelity and child restraint system design in motor vehicle crashes.

Comparison of different passive knee extension torque-angle assessments.

PubMed

Freitas, Sandro R; Vaz, João R; Bruno, Paula M; Valamatos, Maria J; Mil-Homens, Pedro

2013-11-01

Previous studies have used isokinetic dynamometry to assess joint torques and angles during passive extension of the knee, often without reporting upon methodological errors and reliability outcomes. In addition, the reliability of the techniques used to measure passive knee extension torque-angle and the extent to which reliability may be affected by the position of the subjects is also unclear. Therefore, we conducted an analysis of the intra- and inter-session reliability of two methods of assessing passive knee extension: (A) a 2D kinematic analysis coupled to a custom-made device that enabled the direct measurement of resistance to stretch and (B) an isokinetic dynamometer used in two testing positions (with the non-tested thigh either flexed at 45° or in the neutral position). The intra-class correlation coefficients (ICCs) of torque, the slope of the torque-angle curve, and the parameters of the mathematical model that were fit to the torque-angle data for the above conditions were measured in sixteen healthy male subjects (age: 21.4 ± 2.1 yr; BMI: 22.6 ± 3.3 kg m(-2); tibial length: 37.4 ± 3.4 cm). The results found were: (1) methods A and B led to distinctly different torque-angle responses; (2) passive torque-angle relationship and stretch tolerance were influenced by the position of the non-tested thigh; and (3) ICCs obtained for torque were higher than for the slope and for the mathematical parameters that were fit to the torque-angle curve. In conclusion, the measurement method that is used and the positioning of subjects can influence the passive knee extension torque-angle outcome.

A validation of LTRAN2 with high frequency extensions by comparisons with experimental measurements of unsteady transonic flows

NASA Technical Reports Server (NTRS)

Hessenius, K. A.; Goorjian, P. M.

1981-01-01

A high frequency extension of the unsteady, transonic code LTRAN2 was created and is evaluated by comparisons with experimental results. The experimental test case is a NACA 64A010 airfoil in pitching motion at a Mach number of 0.8 over a range of reduced frequencies. Comparisons indicate that the modified code is an improvement of the original LTRAN2 and provides closer agreement with experimental lift and moment coefficients. A discussion of the code modifications, which involve the addition of high frequency terms of the boundary conditions of the numerical algorithm, is included.

Scan-Based Implementation of JPEG 2000 Extensions

NASA Technical Reports Server (NTRS)

Rountree, Janet C.; Webb, Brian N.; Flohr, Thomas J.; Marcellin, Michael W.

2001-01-01

JPEG 2000 Part 2 (Extensions) contains a number of technologies that are of potential interest in remote sensing applications. These include arbitrary wavelet transforms, techniques to limit boundary artifacts in tiles, multiple component transforms, and trellis-coded quantization (TCQ). We are investigating the addition of these features to the low-memory (scan-based) implementation of JPEG 2000 Part 1. A scan-based implementation of TCQ has been realized and tested, with a very small performance loss as compared with the full image (frame-based) version. A proposed amendment to JPEG 2000 Part 2 will effect the syntax changes required to make scan-based TCQ compatible with the standard.

Fall 2012 Graduate Engineering Internship Summary

NASA Technical Reports Server (NTRS)

Ehrlich, Joshua

2013-01-01

In the fall of 2012, I participated in the National Aeronautics and Space Administration (NASA) Pathways Intern Employment Program at the Kennedy Space Center (KSC) in Florida. This was my second internship opportunity with NASA, a consecutive extension from a summer 2012 internship. During my four-month tenure, I gained valuable knowledge and extensive hands-on experience with payload design and testing as well as composite fabrication for repair design on future space vehicle structures. As a systems engineer, I supported the systems engineering and integration team with the testing of scientific payloads such as the Vegetable Production System (Veggie). Verification and validation (V&V) of the Veggie was carried out prior to qualification testing of the payload, which incorporated a lengthy process of confirming design requirements that were integrated through one or more validatjon methods: inspection, analysis, demonstration, and testing. Additionally, I provided assistance in verifying design requirements outlined in the V&V plan with the requirements outlined by the scientists in the Science Requirements Envelope Document (SRED). The purpose of the SRED was to define experiment requirements intended for the payload to meet and carry out.

Immediate effects of whole body vibration on patellar tendon properties and knee extension torque.

PubMed

Rieder, F; Wiesinger, H-P; Kösters, A; Müller, E; Seynnes, O R

2016-03-01

Reports about the immediate effects of whole body vibration (WBV) exposure upon torque production capacity are inconsistent. However, the changes in the torque-angle relationship observed by some authors after WBV may hinder the measurement of torque changes at a given angle. Acute changes in tendon mechanical properties do occur after certain types of exercise but this hypothesis has never been tested after a bout of WBV. The purpose of the present study was to investigate whether tendon compliance is altered immediately after WBV, effectively shifting the optimal angle of peak torque towards longer muscle length. Twenty-eight subjects were randomly assigned to either a WBV (n = 14) or a squatting control group (n = 14). Patellar tendon CSA, stiffness and Young's modulus and knee extension torque-angle relationship were measured using ultrasonography and dynamometry 1 day before and directly after the intervention. Tendon CSA was additionally measured 24 h after the intervention to check for possible delayed onset of swelling. The vibration intervention had no effects on patellar tendon CSA, stiffness and Young's modulus or the torque-angle relationship. Peak torque was produced at ~70° knee angle in both groups at pre- and post-test. Additionally, the knee extension torque globally remained unaffected with the exception of a small (-6%) reduction in isometric torque at a joint angle of 60°. The present results indicate that a single bout of vibration exposure does not substantially alter patellar tendon properties or the torque-angle relationship of knee extensors.

Experimental study using Nearfield Acoustical Holography of sound transmission fuselage sidewall structures

NASA Technical Reports Server (NTRS)

Maynard, J. D.

1983-01-01

This project involves the development of the Nearfield Acoustic Holography (NAH) technique (in particular its extension from single frequency to wideband noise measurement) and its application in a detailed study of the noise radiation characteristics of several samples of aircraft sidewall panels. With the extensive amount of information provided by the NAH technique, the properties of the sound field radiated by the panels may be correlated with their structure, mounting, and excitation (single frequency or wideband, spatially correlated or uncorrelated, structure-borne). The work accomplished at the beginning of this grant period included: (1) Calibration of the 256 microphone array and test of its accuracy. (2) extension of the facility to permit measurements on wideband noise sources. The extensions incuded the addition of high-speed data acquisition hardware and an array processor, and the development of new software. (3) Installation of motion picture graphics for correlating panel motion with structure, mounting, radiation, etc. (4) Development of new holographic data processing techniques.

Multi-material poly(lactic acid) scaffold fabricated via fused deposition modeling and direct hydroxyapatite injection as spacers in laminoplasty

NASA Astrophysics Data System (ADS)

Syuhada, Ghifari; Ramahdita, Ghiska; Rahyussalim, A. J.; Whulanza, Yudan

2018-02-01

Nowadays, additive manufacturing method has been used extensively to realize any product with specific attributes rather than the conventional subtractive manufacturing method. For instance, the additive manufacturing has enable us to construct a product layer-by-layer by successively depositing several materials in one session and one platform. This paper studied the properties of a 3D printed scaffold fabricated through Poly(Lactic-acid) (PLA) deposition modelling in combination with injectable hydroxyapatite (HA)/alginate as cell carrier. The scaffold was designed to serve as a spacer in cervical laminoplasty. Therefore, a series of test were conducted to elaborate the mechanical property, porosity and in-vitro toxicity testing. The results showed that the method is reliable to fabricate the scaffold as desired although the toxicity test needs more confirmation.

Phase 1 Space Fission Propulsion System Testing and Development Progress

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Houts, Mike; Godfroy, Tom; Dickens, Ricky; Poston, David; Kapernick, Rick; Reid, Bob; Salvail, Pat; Ring, Peter; Schafer, Charles (Technical Monitor)

2001-01-01

Successful development of space fission systems requires an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system performance and lifetime can be attained through a series of non-nuclear tests. The Safe Affordable Fission Engine (SAFE) test series, whose ultimate goal is the demonstration of a 300 kW flight configuration system, has demonstrated that realistic testing can be performed using non-nuclear methods. This test series, carried out in collaboration with other NASA centers, other government agencies, industry, and universities, successfully completed a testing program with a 30 kWt core, Stirling engine, and ion engine configuration. Additionally, a 100 kWt core is in fabrication and appropriate test facilities are being reconfigured. This paper describes the current SAFE non-nuclear tests, which includes test article descriptions, test results and conclusions, and future test plans.

Development of automotive battery systems capable of surviving modern underhood environments

NASA Astrophysics Data System (ADS)

Pierson, John R.; Johnson, Richard T.

The starting, lighting, and ignition (SLI) battery in today's automobile typically finds itself in an engine compartment that is jammed with mechanical, electrical, and electronic devices. The spacing of these devices precludes air movement and, thus, heat transfer out of the compartment. Furthermore, many of the devices, in addition to the internal combustion engine, actually generate heat. The resulting underhood environment is extremely hostile to thermally-sensitive components, especially the battery. All indications point to a continuation of this trend towards higher engine-compartment temperatures as future vehicles evolve. The impact of ambient temperature on battery life is clearly demonstrated in the failure-mode analysis conducted by the Battery Council International in 1990. This study, when combined with additional failure-mode analyses, vehicle systems simulation, and elevated temperature life testing, provides insight into the potential for extension of life of batteries. Controlled fleet and field tests are used to document and quantify improvements in product design. Three approaches to battery life extension under adverse thermal conditions are assessed, namely: (i) battery design; (ii) thermal management, and (iii) alternative battery locations. The advantages and disadvantages of these approaches (both individually and in combination) for original equipment and aftermarket applications are explored.

MMS Observatory TV Results Contamination Summary

NASA Technical Reports Server (NTRS)

Rosecrans, Glenn; Brieda, Lubos; Errigo, Therese

2014-01-01

The Magnetospheric Multiscale (MMS) mission is a constellation of 4 observatories designed to investigate the fundamental plasma physics of reconnection in the Earth's magnetosphere. The various instrument suites measure electric and magnetic fields, energetic particles, and plasma composition. Each spacecraft has undergone extensive environmental testing to prepare it for its minimum 2 year mission. In this paper, we report on the extensive thermal vacuum testing campaign. The testing was performed at the Naval Research Laboratory utilizing the "Big Blue" vacuum chamber. A total of ten thermal vacuum tests were performed, including two chamber certifications, three dry runs, and five tests of the individual MMS observatories. During the test, the observatories were enclosed in a thermal enclosure known as the "hamster cage". The enclosure allowed for a detailed thermal control of various observatory zone, but at the same time, imposed additional contamination and system performance requirements. The environment inside the enclosure and the vacuum chamber was actively monitored by several QCMs, RGA, and up to 18 ion gauges. Each spacecraft underwent a bakeout phase, which was followed by 4 thermal cycles. Unique aspects of the TV campaign included slow pump downs with a partial represses, thruster firings, Helium identification, and monitoring pressure spikes with ion gauges. Selected data from these TV tests is presented along with lessons learned.

Neural correlates of retrieval-based memory enhancement: An fMRI study of the testing effect

PubMed Central

Wing, Erik A.; Marsh, Elizabeth J.; Cabeza, Roberto

2013-01-01

Restudying material is a common method for learning new information, but not necessarily an effective one. Research on the testing effect shows that practice involving retrieval from memory can facilitate later memory in contrast to passive restudy. Despite extensive behavioral work, the brain processes that make retrieval an effective learning strategy remain unclear. In the present experiment, we explored how initially retrieving items affected memory a day later as compared to a condition involving traditional restudy. In contrast to restudy, initial testing that contributed to future memory success was associated with engagement of several regions including the anterior hippocampus, lateral temporal cortices, and medial prefrontal cortex (PFC). Additionally, testing enhanced hippocampal connectivity with ventrolateral PFC and midline regions. These findings indicate that the testing effect may be contingent on processes that are typically thought to support memory success at encoding (e.g. relational binding, selection and elaboration of semantically-related information) in addition to those more often associated with retrieval (e.g. memory search). PMID:23607935

Radiation Effects on Current Field Programmable Technologies

NASA Technical Reports Server (NTRS)

Katz, R.; LaBel, K.; Wang, J. J.; Cronquist, B.; Koga, R.; Penzin, S.; Swift, G.

1997-01-01

Manufacturers of field programmable gate arrays (FPGAS) take different technological and architectural approaches that directly affect radiation performance. Similar y technological and architectural features are used in related technologies such as programmable substrates and quick-turn application specific integrated circuits (ASICs). After analyzing current technologies and architectures and their radiation-effects implications, this paper includes extensive test data quantifying various devices total dose and single event susceptibilities, including performance degradation effects and temporary or permanent re-configuration faults. Test results will concentrate on recent technologies being used in space flight electronic systems and those being developed for use in the near term. This paper will provide the first extensive study of various configuration memories used in programmable devices. Radiation performance limits and their impacts will be discussed for each design. In addition, the interplay between device scaling, process, bias voltage, design, and architecture will be explored. Lastly, areas of ongoing research will be discussed.

Extension algorithm for generic low-voltage networks

NASA Astrophysics Data System (ADS)

Marwitz, S.; Olk, C.

2018-02-01

Distributed energy resources (DERs) are increasingly penetrating the energy system which is driven by climate and sustainability goals. These technologies are mostly connected to low- voltage electrical networks and change the demand and supply situation in these networks. This can cause critical network states. Network topologies vary significantly and depend on several conditions including geography, historical development, network design or number of network connections. In the past, only some of these aspects were taken into account when estimating the network investment needs for Germany on the low-voltage level. Typically, fixed network topologies are examined or a Monte Carlo approach is used to quantify the investment needs at this voltage level. Recent research has revealed that DERs differ substantially between rural, suburban and urban regions. The low-voltage network topologies have different design concepts in these regions, so that different network topologies have to be considered when assessing the need for network extensions and investments due to DERs. An extension algorithm is needed to calculate network extensions and investment needs for the different typologies of generic low-voltage networks. We therefore present a new algorithm, which is capable of calculating the extension for generic low-voltage networks of any given topology based on voltage range deviations and thermal overloads. The algorithm requires information about line and cable lengths, their topology and the network state only. We test the algorithm on a radial, a loop, and a heavily meshed network. Here we show that the algorithm functions for electrical networks with these topologies. We found that the algorithm is able to extend different networks efficiently by placing cables between network nodes. The main value of the algorithm is that it does not require any information about routes for additional cables or positions for additional substations when it comes to estimating network extension needs.

Multilayer Pressure Vessel Materials Testing and Analysis Phase 2

NASA Technical Reports Server (NTRS)

Popelar, Carl F.; Cardinal, Joseph W.

2014-01-01

To provide NASA with a suite of materials strength, fracture toughness and crack growth rate test results for use in remaining life calculations for the vessels described above, Southwest Research Institute® (SwRI®) was contracted in two phases to obtain relevant material property data from a representative vessel. An initial characterization of the strength, fracture and fatigue crack growth properties was performed in Phase 1. Based on the results and recommendations of Phase 1, a more extensive material property characterization effort was developed in this Phase 2 effort. This Phase 2 characterization included additional strength, fracture and fatigue crack growth of the multilayer vessel and head materials. In addition, some more limited characterization of the welds and heat affected zones (HAZs) were performed. This report

Analysis of lead-acid battery accelerated testing data

NASA Astrophysics Data System (ADS)

Clifford, J. E.; Thomas, R. E.

1983-06-01

Battelle conducted an independent review and analysis of the accelerated test procedures and test data obtained by Exide in the 3 year Phase 1 program to develop advanced lead acid batteries for utility load leveling. Of special importance is the extensive data obtained in deep discharge cycling tests on 60 cells at elevated temperatures over a 2-1/2 year period. The principal uncertainty in estimating cell life relates to projecting cycle life data at elevated temperature to the lower operating temperatures. The accelerated positive grid corrosion test involving continuous overcharge at 500C provided some indication of the degree of grid corrosion that might be tolerable before failure. The accelerated positive material shedding test was not examined in any detail. Recommendations are made for additional studies.

Assumed--stress hybrid elements with drilling degrees of freedom for nonlinear analysis of composite structures

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr. (Principal Investigator)

1996-01-01

The goal of this research project is to develop assumed-stress hybrid elements with rotational degrees of freedom for analyzing composite structures. During the first year of the three-year activity, the effort was directed to further assess the AQ4 shell element and its extensions to buckling and free vibration problems. In addition, the development of a compatible 2-node beam element was to be accomplished. The extensions and new developments were implemented in the Computational Structural Mechanics Testbed COMET. An assessment was performed to verify the implementation and to assess the performance of these elements in terms of accuracy. During the second and third years, extensions to geometrically nonlinear problems were developed and tested. This effort involved working with the nonlinear solution strategy as well as the nonlinear formulation for the elements. This research has resulted in the development and implementation of two additional element processors (ES22 for the beam element and ES24 for the shell elements) in COMET. The software was developed using a SUN workstation and has been ported to the NASA Langley Convex named blackbird. Both element processors are now part of the baseline version of COMET.

Manual muscle testing and hand-held dynamometry in people with inflammatory myopathy: An intra- and interrater reliability and validity study

PubMed Central

Baschung Pfister, Pierrette; Sterkele, Iris; Maurer, Britta; de Bie, Rob A.; Knols, Ruud H.

2018-01-01

Manual muscle testing (MMT) and hand-held dynamometry (HHD) are commonly used in people with inflammatory myopathy (IM), but their clinimetric properties have not yet been sufficiently studied. To evaluate the reliability and validity of MMT and HHD, maximum isometric strength was measured in eight muscle groups across three measurement events. To evaluate reliability of HHD, intra-class correlation coefficients (ICC), the standard error of measurements (SEM) and smallest detectable changes (SDC) were calculated. To measure reliability of MMT linear Cohen`s Kappa was computed for single muscle groups and ICC for total score. Additionally, correlations between MMT8 and HHD were evaluated with Spearman Correlation Coefficients. Fifty people with myositis (56±14 years, 76% female) were included in the study. Intra-and interrater reliability of HHD yielded excellent ICCs (0.75–0.97) for all muscle groups, except for interrater reliability of ankle extension (0.61). The corresponding SEMs% ranged from 8 to 28% and the SDCs% from 23 to 65%. MMT8 total score revealed excellent intra-and interrater reliability (ICC>0.9). Intrarater reliability of single muscle groups was substantial for shoulder and hip abduction, elbow and neck flexion, and hip extension (0.64–0.69); moderate for wrist (0.53) and knee extension (0.49) and fair for ankle extension (0.35). Interrater reliability was moderate for neck flexion (0.54) and hip abduction (0.44); fair for shoulder abduction, elbow flexion, wrist and ankle extension (0.20–0.33); and slight for knee extension (0.08). Correlations between the two tests were low for wrist, knee, ankle, and hip extension; moderate for elbow flexion, neck flexion and hip abduction; and good for shoulder abduction. In conclusion, the MMT8 total score is a reliable assessment to consider general muscle weakness in people with myositis but not for single muscle groups. In contrast, our results confirm that HHD can be recommended to evaluate strength of single muscle groups. PMID:29596450

Economic and microbiologic evaluation of single-dose vial extension for hazardous drugs.

PubMed

Rowe, Erinn C; Savage, Scott W; Rutala, William A; Weber, David J; Gergen-Teague, Maria; Eckel, Stephen F

2012-07-01

The update of US Pharmacopeia Chapter <797> in 2008 included guidelines stating that single-dose vials (SDVs) opened and maintained in an International Organization for Standardization Class 5 environment can be used for up to 6 hours after initial puncture. A study was conducted to evaluate the cost of discarding vials after 6 hours and to further test sterility of vials beyond this time point, subsequently defined as the beyond-use date (BUD). Financial determination of SDV waste included 2 months of retrospective review of all doses prescribed. Additionally, actual waste log data were collected. Active and control vials (prepared using sterilized trypticase soy broth) were recovered, instead of discarded, at the defined 6-hour BUD. The institution-specific waste of 19 selected SDV medications discarded at 6 hours was calculated at $766,000 annually, and tracking waste logs for these same medications was recorded at $770,000 annually. Microbiologic testing of vial extension beyond 6 hours showed that 11 (1.86%) of 592 samples had one colony-forming unit on one of two plates. Positive plates were negative at subsequent time points, and all positives were single isolates most likely introduced during the plating process. The cost of discarding vials at 6 hours was significant for hazardous medications in a large academic medical center. On the basis of microbiologic data, vial BUD extension demonstrated a contamination frequency of 1.86%, which likely represented exogenous contamination; vial BUD extension for the tested drugs showed no growth at subsequent time points and could provide an annual cost savings of more than $600,000.

Production development of organic nonflammable spacecraft potting, encapsulating and conformal coating compounds. Volume 1: Discussion, figures, and references

NASA Technical Reports Server (NTRS)

Lieberman, S. L.

1974-01-01

Based upon extensive contacts with vendors, a broad array of non-flammable polymeric specie, and additives generally noted to have flame retarding properties, were considered. The following polymeric matrices were examined: modified silicone and fluorosilicone RTV's polyesters, epoxies, urethanes, and epoxy-urethanes. Optimization of formulations to obtain a suitable balance between the various properties and flammability resistance led to the final selection of a silicone RTV/additive-loaded compound which meets almost all program requirements. The very low valued properties found are within a realistic level of design toleration. Complete formulation, processing, and test data is provided for this compound, EPOCAST 87517-A/B, and the other formulations prepared by the project. Details of those test methods are presented along with procedures utilized in the program. In addition, a description of the special flammability facility previously designed and then modified for this program is also presented.

Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity.

PubMed

Ahn, Jongmin; Chae, Hee-Sung; Chin, Young-Won; Kim, Jinwoong

2017-06-15

New alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC 50 value of 8.7μM. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Study on the Effects of Sympathetic Skin Response Parameters in Diagnosis of Fibromyalgia Using Artificial Neural Networks.

PubMed

Ozkan, Ozhan; Yildiz, Murat; Arslan, Evren; Yildiz, Sedat; Bilgin, Suleyman; Akkus, Selami; Koyuncuoglu, Hasan R; Koklukaya, Etem

2016-03-01

Fibromyalgia syndrome (FMS), usually observed commonly in females over age 30, is a rheumatic disease accompanied by extensive chronic pain. In the diagnosis of the disease non-objective psychological tests and physiological tests and laboratory test results are evaluated and clinical experiences stand out. However, these tests are insufficient in differentiating FMS with similar diseases that demonstrate symptoms of extensive pain. Thus, objective tests that would help the diagnosis are needed. This study analyzes the effect of sympathetic skin response (SSR) parameters on the auxiliary tests used in FMS diagnosis, the laboratory tests and physiological tests. The study was conducted in Suleyman Demirel University, Faculty of Medicine, Physical Medicine and Rehabilitation Clinic in Turkey with 60 patients diagnosed with FMS for the first time and a control group of 30 healthy individuals. In the study all participants underwent laboratory tests (blood tests), certain physiological tests (pulsation, skin temperature, respiration) and SSR measurements. The test data and SSR parameters obtained were classified using artificial neural network (ANN). Finally, in the ANN framework, where only laboratory and physiological test results were used as input, a simulation result of 96.51 % was obtained, which demonstrated diagnostic accuracy. This data, with the addition of SSR parameter values obtained increased to 97.67 %. This result including SSR parameters - meaning a higher diagnostic accuracy - demonstrated that SSR could be a new auxillary diagnostic method that could be used in the diagnosis of FMS.

Occupant Kinematics in Laboratory Rollover Tests: ATD Response and Biofidelity.

PubMed

Zhang, Qi; Lessley, David L; Riley, Patrick; Toczyski, Jacek; Lockerby, Jack; Foltz, Patrick; Overby, Brian; Seppi, Jeremy; Crandall, Jeff R; Kerrigan, Jason R

2014-11-01

Rollover crashes are a serious public health problem in United States, with one third of traffic fatalities occurring in crashes where rollover occurred. While it has been shown that occupant kinematics affect the injury risk in rollover crashes, no anthropomorphic test device (ATD) has yet demonstrated kinematic biofidelity in rollover crashes. Therefore, the primary goal of this study was to assess the kinematic response biofidelity of six ATDs (Hybrid III, Hybrid III Pedestrian, Hybrid III with Pedestrian Pelvis, WorldSID, Polar II and THOR) by comparing them to post mortem human surrogate (PMHS) kinematic response targets published concurrently; and the secondary goal was to evaluate and compare the kinematic response differences among these ATDs. Trajectories (head, T1, T4, T10, L1 and sacrum), spinal segment (head-to-T1, T1-to-T4, T4-T10, T10-L1, and L1-to-sacrum) rotations relative to the rollover buck, and spinal segment extension/compression were calculated from the collected kinematics data from an optical motion tracking system. Response differences among the ATDs were observed mainly due to the different lateral bending stiffness of the spine from their varied architecture, while the additional thoracic joint in Polar II and THOR did not seem to provide more flexion/extension compliance than the other ATDs. In addition, the ATD response data were compared to PMHS response corridors developed from similar tests for assessing ATD biofidelity. All of the ATDs, generally, drifted outboard and upward during the tests similar to the PMHS. However, accompanied with this upward and outward motion, the ATD head and upper torso pitched forward (~10 degrees) while the PMHS' head and upper torso pitching rearward (~10 to ~15 degrees), due to the absence of flexion/extension compliance in the ATD spine. The differences in these pitch motions resulted in a difference of 130 mm to 160 mm in the longitudinal position of the head at 195 degrees of roll angle. Finally, substantially less lateral spinal bending was also observed in the ATDs compared to the PMHS. The results of the current study suggests there is greater upper spine flexion/extension, and lateral bending stiffness in all of the ATDs in comparison to the PMHS, and provided information for improvement of ATD biofidelity in future for rollover crashes.

A fiber-coupled 9xx module with tap water cooling

NASA Astrophysics Data System (ADS)

Schleuning, D.; Anthon, D.; Chryssis, A.; Ryu, G.; Liu, G.; Winhold, H.; Fan, L.; Xu, Z.; Tanbun-Ek, T.; Lehkonen, S.; Acklin, B.

2016-03-01

A novel, 9XX nm fiber-coupled module using arrays of highly reliable laser diode bars has been developed. The module is capable of multi-kW output power in a beam parameter product of 80 mm-mrad. The module incorporates a hard-soldered, isolated stack package compatible with tap-water cooling. Using extensive, accelerated multi-cell life-testing, with more than ten million device hours of test, we have demonstrated a MTTF for emitters of >500,000 hrs. In addition we have qualified the module in hard-pulse on-off cycling and stringent environmental tests. Finally we have demonstrated promising results for a next generation 9xx nm chip design currently in applications and qualification testing

Principled Design of an Augmented Reality Trainer for Medics

DTIC Science & Technology

2018-04-13

retake test is scheduled. In addition, extensive simulation capstone scenarios are run with a full body manikin that includes airway management...platform so they could run with high quality graphical resolution. We updated the underlying data models to reflect the training scenario parameters...Sedeh, P., Schumann, M., & Groeben, H. (2009). Laryngoscopy via Macintosh blade versus GlideScope: Success rate and time for endotracheal intubation

Additional Evidence for the Reliability and Validity of the Student Risk Screening Scale at the High School Level: A Replication and Extension

ERIC Educational Resources Information Center

Lane, Kathleen Lynne; Oakes, Wendy P.; Ennis, Robin Parks; Cox, Meredith Lucille; Schatschneider, Christopher; Lambert, Warren

2013-01-01

This study reports findings from a validation study of the Student Risk Screening Scale for use with 9th- through 12th-grade students (N = 1854) attending a rural fringe school. Results indicated high internal consistency, test-retest stability, and inter-rater reliability. Predictive validity was established across two academic years, with Spring…

Post-analysis report on Chesapeake Bay data processing. [spectral analysis and recognition computer signature extension

NASA Technical Reports Server (NTRS)

Thomson, F.

1972-01-01

The additional processing performed on data collected over the Rhode River Test Site and Forestry Site in November 1970 is reported. The techniques and procedures used to obtain the processed results are described. Thermal data collected over three approximately parallel lines of the site were contoured, and the results color coded, for the purpose of delineating important scene constituents and to identify trees attacked by pine bark beetles. Contouring work and histogram preparation are reviewed and the important conclusions from the spectral analysis and recognition computer (SPARC) signature extension work are summarized. The SPARC setup and processing records are presented and recommendations are made for future data collection over the site.

Robust Platinum Resistor Thermometer (PRT) Sensors and Reliable Bonding for Space Missions

NASA Technical Reports Server (NTRS)

Cucullu, Gordy C., III; Mikhaylov, Rebecca; Rajeshuni, Ramesham; Petkov, Mihail; Hills, David; Uribe, Jose; Okuno, James; De Los Santos, Greg

2013-01-01

Platinum resistance thermometers (PRTs) provide accurate temperature measurements over a wide temperature range and are used extensively on space missions due to their simplicity and linearity. A standard on spacecraft, PRTs are used to provide precision temperature control and vehicle health assessment. This paper reviews the extensive reliability testing of platinum resistor thermometer sensors (PRTs) and bonding methods used on the Mars Science Laboratory (MSL) mission and for the upcoming Soil Moisture Active Passive (SMAP) mission. During the Mars Exploration Rover (MER) mission, several key, JPL-packaged PRTs failed on those rovers prior to and within 1-Sol of landing due to thermally induced stresses. Similar failures can be traced back to other JPL missions dating back thirty years. As a result, MSL sought out a PRT more forgiving to the packaging configurations used at JPL, and extensively tested the Honeywell HRTS-5760-B-U-0-12 sensor to successfully demonstrate suitable robustness to thermal cycling. Specifically, this PRT was cycled 2,000 times, simulating three Martian winters and summers. The PRTs were bonded to six substrate materials (Aluminum 7050, treated Magnesium AZ231-B, Stainless Steel 304, Albemet, Titanium 6AL4V, and G-10), using four different aerospace adhesives--two epoxies and two silicones--that conformed to MSL's low out-gassing requirements. An additional epoxy was tested in a shorter environmental cycling test, when the need for a different temperature range adhesive was necessary for mobility and actuator hardware late in the fabrication process. All of this testing, along with electrostatic discharge (ESD) and destructive part analyses, demonstrate that this PRT is highly robust, and not subject to the failure of PRTs on previous missions. While there were two PRTs that failed during fabrication, to date there have been no in-flight PRT failures on MSL, including those on the Curiosity rover. Since MSL, the sensor has gone through a change in construction such that the manufacturer significantly restricts the minimum temperature. However, significant subsequent testing was performed with this new version of the part to show that it indeed is still robust to at least Mars minimum temperatures of -135(sup o)C. The additional completed testing will be described. This work has resulted in a successful sensor package qualification and a reliable bonding method suitable for use over large temperature extremes.

Robust Platinum Resistor Thermometer (PRT) Sensors and Reliable Bonding for Space Missions

NASA Technical Reports Server (NTRS)

Cucullu, Gordy C. III; Mikhaylov, Rebecca; Ramesham, Rajeshuni; Petkov, Mihail; Hills, David; Uribe, Jose; Okuno, James; De Los Santos, Greg

2013-01-01

Platinum resistance thermometers (PRTs) provide accurate temperature measurements over a wide temperature range and are used extensively on space missions due to their simplicity and linearity. A standard on spacecraft, PRTs are used to provide precision temperature control and vehicle health assessment. This paper reviews the extensive reliability testing of platinum resistor thermometer sensors (PRTs) and bonding methods used on the Mars Science Laboratory (MSL) mission and for the upcoming Soil Moisture Active Passive (SMAP) mission. During the Mars Exploration Rover (MER) mission, several key, JPL-packaged PRTs failed on those rovers prior to and within 1-Sol of landing due to thermally induced stresses. Similar failures can be traced back to other JPL missions dating back thirty years. As a result, MSL sought out a PRT more forgiving to the packaging configurations used at JPL, and extensively tested the Honeywell HRTS-5760-B-U-0-12 sensor to successfully demonstrate suitable robustness to thermal cycling. Specifically, this PRT was cycled 2,000 times, simulating three Martian winters and summers. The PRTs were bonded to six substrate materials (Aluminum 7050, treated Magnesium AZ231-B, Stainless Steel 304, Albemet, Titanium 6AL4V, and G-10), using four different aerospace adhesives--two epoxies and two silicones--that conformed to MSL's low out-gassing requirements. An additional epoxy was tested in a shorter environmental cycling test, when the need for a different temperature range adhesive was necessary for mobility and actuator hardware late in the fabrication process. All of this testing, along with electrostatic discharge (ESD) and destructive part analyses, demonstrate that this PRT is highly robust, and not subject to the failure of PRTs on previous missions. While there were two PRTs that failed during fabrication, to date there have been no in-flight PRT failures on MSL, including those on the Curiosity rover. Since MSL, the sensor has gone through a change in construction such that the manufacturer significantly restricts the minimum temperature. However, significant subsequent testing was performed with this new version of the part to show that it indeed is still robust to at least Mars minimum temperatures of -135 degrees Centigrade. The additional completed testing will be described. This work has resulted in a successful sensor package qualification and a reliable bonding method suitable for use over large temperature extremes

Using GIS to analyze animal movements in the marine environment

USGS Publications Warehouse

Hooge, Philip N.; Eichenlaub, William M.; Solomon, Elizabeth K.; Kruse, Gordon H.; Bez, Nicolas; Booth, Anthony; Dorn, Martin W.; Hills, Susan; Lipcius, Romuald N.; Pelletier, Dominique; Roy, Claude; Smith, Stephen J.; Witherell, David B.

2001-01-01

Advanced methods for analyzing animal movements have been little used in the aquatic research environment compared to the terrestrial. In addition, despite obvious advantages of integrating geographic information systems (GIS) with spatial studies of animal movement behavior, movement analysis tools have not been integrated into GIS for either aquatic or terrestrial environments. We therefore developed software that integrates one of the most commonly used GIS programs (ArcView®) with a large collection of animal movement analysis tools. This application, the Animal Movement Analyst Extension (AMAE), can be loaded as an extension to ArcView® under multiple operating system platforms (PC, Unix, and Mac OS). It contains more than 50 functions, including parametric and nonparametric home range analyses, random walk models, habitat analyses, point and circular statistics, tests of complete spatial randomness, tests for autocorrelation and sample size, point and line manipulation tools, and animation tools. This paper describes the use of these functions in analyzing animal location data; some limited examples are drawn from a sonic-tracking study of Pacific halibut (Hippoglossus stenolepis) in Glacier Bay, Alaska. The extension is available on the Internet at www.absc.usgs.gov/glba/gistools/index.htm.

Formulation and evaluation of C-Ether fluids as lubricants useful to 260 C. [air breathing engines

NASA Technical Reports Server (NTRS)

Clark, F. S.; Miller, D. R.

1980-01-01

Three base stocks were evaluated in bench and bearing tests to determine their suitability for use at bulk oil temperatures (BOT) from -40 C to +260 C. A polyol ester gave good bearing tests at a bulk temperature of 218 C, but only a partially successful run at 274 C. These results bracket the fluid's maximum operating temperature between these values. An extensive screening program selected lubrication additives for a C-ether (modified polyphenyl ether) base stock. One formulation lubricated a bearing for 111 hours at 274 C (BOT), but this fluid gave many deposit related problems. Other C-ether blends produced cage wear or fatigue failures. Studies of a third fluid, a C-ether/disiloxane blend, consisted of bench oxidation and lubrication tests. These showed that some additives react differently in the blend than in pure C-ethers.

Application of improved technology to a preprototype vapor compression distillation /VCD/ water recovery subsystem

NASA Technical Reports Server (NTRS)

Johnson, K. L.; Reysa, R. P.; Fricks, D. H.

1981-01-01

Vapor compression distillation (VCD) is considered the most efficient water recovery process for spacecraft application. This paper reports on a preprototype VCD which has undergone the most extensive operational and component development testing of any VCD subsystem to date. The component development effort was primarily aimed at eliminating corrosion and the need for lubrication, upgrading electronics, and substituting nonmetallics in key rotating components. The VCD evolution is documented by test results on specific design and/or materials changes. Innovations worthy of further investigation and additional testing are summarized for future VCD subsystem development reference. Conclusions on experience gained are presented.

Techniques for Liquid Rocket Combustion Spontaneous Stability and Rough Combustion Assessments

NASA Technical Reports Server (NTRS)

Kenny, R. J.; Giacomoni, C.; Casiano, M. J.; Fischbach, S. R.

2016-01-01

This work presents techniques for liquid rocket engine combustion stability assessments with respect to spontaneous stability and rough combustion. Techniques covering empirical parameter extraction, which were established in prior works, are applied for three additional programs: the F-1 Gas Generator (F1GG) component test program, the RS-84 preburner component test program, and the Marshall Integrated Test Rig (MITR) program. Stability assessment parameters from these programs are compared against prior established spontaneous stability metrics and updates are identified. Also, a procedure for comparing measured with predicted mode shapes is presented, based on an extension of the Modal Assurance Criterion (MAC).

Comparison of erector spinae and hamstring muscle activities and lumbar motion during standing knee flexion in subjects with and without lumbar extension rotation syndrome.

PubMed

Kim, Si-hyun; Kwon, Oh-yun; Park, Kyue-nam; Kim, Moon-Hwan

2013-12-01

The aim of this study was to compare the activity of the erector spinae (ES) and hamstring muscles and the amount and onset of lumbar motion during standing knee flexion between individuals with and without lumbar extension rotation syndrome. Sixteen subjects with lumbar extension rotation syndrome (10 males, 6 females) and 14 healthy subjects (8 males, 6 females) participated in this study. During the standing knee flexion, surface electromyography (EMG) was used to measure muscle activity, and surface EMG electrodes were attached to both the ES and hamstring (medial and lateral) muscles. A three-dimensional motion analysis system was used to measure kinematic data of the lumbar spine. An independent-t test was conducted for the statistical analysis. The group suffering from lumbar extension rotation syndrome exhibited asymmetric muscle activation of the ES and decreased hamstring activity. Additionally, the group with lumbar extension rotation syndrome showed greater and earlier lumbar extension and rotation during standing knee flexion compared to the control group. These data suggest that asymmetric ES muscle activation and a greater amount of and earlier lumbar motion in the sagittal and transverse plane during standing knee flexion may be an important factor contributing to low back pain. Copyright © 2013 Elsevier Ltd. All rights reserved.

Fun During Knee Rehabilitation: Feasibility and Acceptability Testing of a New Android-Based Training Device.

PubMed

Weber-Spickschen, Thomas Sanjay; Colcuc, Christian; Hanke, Alexander; Clausen, Jan-Dierk; James, Paul Abraham; Horstmann, Hauke

2017-01-01

The initial goals of rehabilitation after knee injuries and operations are to achieve full knee extension and to activate quadriceps muscle. In addition to regular physiotherapy, an android-based knee training device is designed to help patients achieve these goals and improve compliance in the early rehabilitation period. This knee training device combines fun in a computer game with muscular training or rehabilitation. Our aim was to test the feasibility and acceptability of this new device. 50 volunteered subjects enrolled to test out the computer game aided device. The first game was the high-striker game, which recorded maximum knee extension power. The second game involved controlling quadriceps muscular power to simulate flying an aeroplane in order to record accuracy of muscle activation. The subjects evaluated this game by completing a simple questionnaire. No technical problem was encountered during the usage of this device. No subjects complained of any discomfort after using this device. Measurements including maximum knee extension power, knee muscle activation and control were recorded successfully. Subjects rated their experience with the device as either excellent or very good and agreed that the device can motivate and monitor the progress of knee rehabilitation training. To the best of our knowledge, this is the first android-based tool available to fast track knee rehabilitation training. All subjects gave very positive feedback to this computer game aided knee device.

eddy4R 0.2.0: a DevOps model for community-extensible processing and analysis of eddy-covariance data based on R, Git, Docker, and HDF5

NASA Astrophysics Data System (ADS)

Metzger, Stefan; Durden, David; Sturtevant, Cove; Luo, Hongyan; Pingintha-Durden, Natchaya; Sachs, Torsten; Serafimovich, Andrei; Hartmann, Jörg; Li, Jiahong; Xu, Ke; Desai, Ankur R.

2017-08-01

Large differences in instrumentation, site setup, data format, and operating system stymie the adoption of a universal computational environment for processing and analyzing eddy-covariance (EC) data. This results in limited software applicability and extensibility in addition to often substantial inconsistencies in flux estimates. Addressing these concerns, this paper presents the systematic development of portable, reproducible, and extensible EC software achieved by adopting a development and systems operation (DevOps) approach. This software development model is used for the creation of the eddy4R family of EC code packages in the open-source R language for statistical computing. These packages are community developed, iterated via the Git distributed version control system, and wrapped into a portable and reproducible Docker filesystem that is independent of the underlying host operating system. The HDF5 hierarchical data format then provides a streamlined mechanism for highly compressed and fully self-documented data ingest and output. The usefulness of the DevOps approach was evaluated for three test applications. First, the resultant EC processing software was used to analyze standard flux tower data from the first EC instruments installed at a National Ecological Observatory (NEON) field site. Second, through an aircraft test application, we demonstrate the modular extensibility of eddy4R to analyze EC data from other platforms. Third, an intercomparison with commercial-grade software showed excellent agreement (R2 = 1.0 for CO2 flux). In conjunction with this study, a Docker image containing the first two eddy4R packages and an executable example workflow, as well as first NEON EC data products are released publicly. We conclude by describing the work remaining to arrive at the automated generation of science-grade EC fluxes and benefits to the science community at large. This software development model is applicable beyond EC and more generally builds the capacity to deploy complex algorithms developed by scientists in an efficient and scalable manner. In addition, modularity permits meeting project milestones while retaining extensibility with time.

The Physical Effects of Contact and Close-Distance Gunfire on Sweatshirt Fleece.

PubMed

Kusluski, Michael A

2018-05-01

Powder stippling caused by the impact of propellant particles during close-distance gunfire has been previously described on skin and solid objects only. Additionally, radial tearing has been described as clear evidence of a contact-distance shot, requiring no further testing. Patterns of discrete perforating holes (referred to here as "stippling perforations") and other physical damage on sweatshirt fleece fabrics were prepared. Using the firearm and ammunition in this study, stippling perforations were observed to a maximum muzzle-to-target distance of 35 cm (10 inches). In addition, radial tearing and disintegration were present (and often more extensive) at greater than contact distance. The presence of stippling perforations could augment muzzle-to-target distance estimates generated using the Griess test, or allow distance estimates when the Griess test is not feasible. Unlike what has been previously reported, testing on the original evidence (or similar substitute) is warranted when physical damage is used to estimate shooting distance. © 2017 American Academy of Forensic Sciences.

Upper Stage Engine Composite Nozzle Extensions

NASA Technical Reports Server (NTRS)

Valentine, Peter G.; Allen, Lee R.; Gradl, Paul R.; Greene, Sandra E.; Sullivan, Brian J.; Weller, Leslie J.; Koenig, John R.; Cuneo, Jacques C.; Thompson, James; Brown, Aaron;

Microdevice for plasma separation from whole human blood using bio-physical and geometrical effects

NASA Astrophysics Data System (ADS)

Tripathi, Siddhartha; Kumar, Y. V. Balavarun; Agrawal, Amit; Prabhakar, Amit; Joshi, Suhas S.

2016-06-01

In this research work, we present a simple and efficient passive microfluidic device for plasma separation from pure blood. The microdevice has been fabricated using conventional photolithography technique on a single layer of polydimethylsiloxane, and has been extensively tested on whole blood and enhanced (upto 62%) hematocrit levels of human blood. The microdevice employs elevated dimensions of about 100 μm such elevated dimensions ensure clog-free operation of the microdevice and is relatively easy to fabricate. We show that our microdevice achieves almost 100% separation efficiency on undiluted blood in the flow rate range of 0.3 to 0.5 ml/min. Detailed biological characterization of the plasma obtained from the microdevice is carried out by testing: proteins by ultra-violet spectrophotometric method, hCG (human chorionic gonadotropin) hormone, and conducting random blood glucose test. Additionally, flow cytometry study has also been carried on the separated plasma. These tests attest to the high quality of plasma recovered. The microdevice developed in this work is an outcome of extensive experimental research on understanding the flow behavior and separation phenomenon of blood in microchannels. The microdevice is compact, economical and effective, and is particularly suited in continuous flow operations.

Reactor-pumped laser facility at DOE's Nevada Test Site

NASA Astrophysics Data System (ADS)

Lipinski, Ronald J.

1994-05-01

The Nevada Test Site (NTS) is one excellent possibility for a laser power beaming site. It is in the low latitudes of the U.S., is in an exceptionally cloud-free area of the southwest, is already an area of restricted access (which enhances safety considerations), and possesses a highly skilled technical team with extensive engineering and research capabilities from underground testing of our nation's nuclear deterrence. The average availability of cloud-free clear line of site to a given point in space is about 84%. With a beaming angle of +/- 60 degree(s) from the zenith, about 52 geostationary-orbit (GEO) satellites could be accessed continuously from NTS. In addition, the site would provide an average view factor of about 10% for orbital transfer from low earth orbit to GEO. One of the major candidates for a long-duration, high- power laser is a reactor-pumped laser being developed by DOE. The extensive nuclear expertise at NTS makes this site a prime candidate for utilizing the capabilities of a rector pumped laser for power beaming. The site then could be used for many dual-use roles such as industrial material processing research, defense testing, and removing space debris.

LLNL electro-optical mine detection program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, C.; Aimonetti, W.; Barth, M.

1994-09-30

Under funding from the Advanced Research Projects Agency (ARPA) and the US Marine Corps (USMC), Lawrence Livermore National Laboratory (LLNL) has directed a program aimed at improving detection capabilities against buried mines and munitions. The program has provided a national test facility for buried mines in arid environments, compiled and distributed an extensive data base of infrared (IR), ground penetrating radar (GPR), and other measurements made at that site, served as a host for other organizations wishing to make measurements, made considerable progress in the use of ground penetrating radar for mine detection, and worked on the difficult problem ofmore » sensor fusion as applied to buried mine detection. While the majority of our effort has been concentrated on the buried mine problem, LLNL has worked with the U.S.M.C. on surface mine problems as well, providing data and analysis to support the COBRA (Coastal Battlefield Reconnaissance and Analysis) program. The original aim of the experimental aspect of the program was the utilization of multiband infrared approaches for the detection of buried mines. Later the work was extended to a multisensor investigation, including sensors other than infrared imagers. After an early series of measurements, it was determined that further progress would require a larger test facility in a natural environment, so the Buried Object Test Facility (BOTF) was constructed at the Nevada Test Site. After extensive testing, with sensors spanning the electromagnetic spectrum from the near ultraviolet to radio frequencies, possible paths for improvement were: improved spatial resolution providing better ground texture discrimination; analysis which involves more complicated spatial queueing and filtering; additional IR bands using imaging spectroscopy; the use of additional sensors other than IR and the use of data fusion techniques with multi-sensor data; and utilizing time dependent observables like temperature.« less

Monitoring crack extension in fracture toughness tests by ultrasonics

NASA Technical Reports Server (NTRS)

Klima, S. J.; Fisher, D. M.; Buzzard, R. J.

1975-01-01

An ultrasonic method was used to observe the onset of crack extension and to monitor continued crack growth in fracture toughness specimens during three point bend tests. A 20 MHz transducer was used with commercially available equipment to detect average crack extension less than 0.09 mm. The material tested was a 300-grade maraging steel in the annealed condition. A crack extension resistance curve was developed to demonstrate the usefulness of the ultrasonic method for minimizing the number of tests required to generate such curves.

Simulated Radioscapholunate Fusion Alters Carpal Kinematics While Preserving Dart-Thrower's Motion

PubMed Central

Calfee, Ryan P.; Leventhal, Evan L.; Wilkerson, Jim; Moore, Douglas C.; Akelman, Edward; Crisco, Joseph J.

2014-01-01

Purpose Midcarpal degeneration is well documented after radioscapholunate fusion. This study tested the hypothesis that radioscapholunate fusion alters the kinematic behavior of the remaining lunotriquetral and midcarpal joints, with specific focus on the dart-thrower's motion. Methods Simulated radioscapholunate fusions were performed on 6 cadaveric wrists in an anatomically neutral posture. Two 0.060-in. carbon fiber pins were placed from proximal to distal across the radiolunate and radioscaphoid joints, respectively. The wrists were passively positioned in a custom jig toward a full range of motion along the orthogonal axes as well as oblique motions, with additional intermediate positions along the dart-thrower's path. Using a computed tomography– based markerless bone registration technique, each carpal bone's three-dimensional rotation was defined as a function of wrist flexion/extension from the pinned neutral position. Kinematic data was analyzed against data collected on the same wrist prior to fixation using hierarchical linear regression analysis and paired Student's t-tests. Results After simulated fusion, wrist motion was restricted to an average flexion-extension arc of 48°, reduced from 77°, and radial-ulnar deviation arc of 19°, reduced from 33°. The remaining motion was maximally preserved along the dart-thrower's path from radial-extension toward ulnar-flexion. The simulated fusion significantly increased rotation through the scaphotrapezial joint, scaphocapitate joint, triquetrohamate joint, and lunotriquetral joint. For example, in the pinned wrist, the rotation of the hamate relative to the triquetrum increased 85%. Therefore, during every 10° of total wrist motion, the hamate rotated an average of nearly 8° relative to the triquetrum after pinning versus 4° in the normal state. Conclusions Simulated radioscapholunate fusion altered midcarpal and lunotriquetral kinematics. The increased rotations across these remaining joints provide one potential explanation for midcarpal degeneration after radioscapholunate fusion. Additionally, this fusion model confirms the dart-thrower's hypothesis, as wrist motion after simulated radioscapholunate fusion was primarily preserved from radial-extension toward ulnar-flexion. PMID:18406953

Calcium bridges are not load-bearing cell-wall bonds in Avena coleoptiles

NASA Technical Reports Server (NTRS)

Rayle, D. L.

1989-01-01

I examined the ability of frozen-thawed Avena sativa L. coleoptile sections under applied load to extend in response to the calcium chelators ethyleneglycol-bis-(beta-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA) and 2-[(2-bis-[carboxymethyl]amino-5-methylphenoxy)methyl]-6-methoxy-8-bis[car boxymethyl]aminoquinoline (Quin II). Addition of 5 mM EGTA to weakly buffered (0.1 mM, pH 6.2) solutions of 2(N-morpholino) ethanesulfonic acid (Mes) initiated rapid extension and wall acidification. When the buffer strength was increased (e.g. from 20 to 100 mM Mes, pH 6.2) EGTA did not initiate extension nor did it cause wall acidification. At 5 mM Quin II failed to stimulate cell extension or wall acidification at all buffer molarities tested (0.1 to 100 mM Mes). Both chelators rapidly and effectively removed Ca2+ from Avena sections. These data indicate that Ca2+ chelation per se does not result in loosening of Avena cells walls. Rather, EGTA promotes wall extension indirectly via wall acidification.

Extending Mondrian Memory Protection

DTIC Science & Technology

2010-11-01

a kernel semaphore is locked or unlocked. In addition, we extended the system call interface to receive notifications about user-land locking...operations (such as calls to the mutex and semaphore code provided by the C library). By patching the dynamically loadable GLibC5, we are able to test... semaphores , and spinlocks. RTO-MP-IST-091 10- 9 Extending Mondrian Memory Protection to loading extension plugins. This prevents any untrusted code

Methods for Assessment of Biodegradability of Plastic Films in Soil †

PubMed Central

Yabannavar, Asha V.; Bartha, Richard

1994-01-01

Traditional and novel techniques were tested and compared for their usefulness in evaluating biodegrad-ability claims made for newly formulated “degradable” plastic film products. Photosensitized polyethylene (PE), starch-PE, extensively plasticized polyvinyl chloride (PVC), and polypropylene (PP) films were incorporated into aerobic soil. Biodegradation was measured for 3 months under generally favorable conditions. Carbon dioxide evolution, residual weight recovery, and loss of tensile strength measurements were supplemented, for some films, by gas chromatographic measurements of plasticizer loss and gel permeation chromatographic (GPC) measurement of polymer molecular size distribution. Six- and 12-week sunlight exposures of photosensitized PE films resulted in extensive photochemical damage that failed to promote subsequent mineralization in soil. An 8% starch-PE film and the plasticized PVC film evolved significant amounts of CO2 in biodegradation tests and lost residual weight and tensile strength, but GPC measurements demonstrated that all these changes were confined to the additives and the PE and PVC polymers were not degraded. Carbon dioxide evolution was found to be a useful screening tool for plastic film biodegradation, but for films with additives, polymer biodegradation needs to be confirmed by GPC. Photochemical cross-linking of polymer strands reduces solubility and may interfere with GPC measurements of polymer degradation. PMID:16349408

Differential correlation for sequencing data.

PubMed

Siska, Charlotte; Kechris, Katerina

2017-01-19

Several methods have been developed to identify differential correlation (DC) between pairs of molecular features from -omics studies. Most DC methods have only been tested with microarrays and other platforms producing continuous and Gaussian-like data. Sequencing data is in the form of counts, often modeled with a negative binomial distribution making it difficult to apply standard correlation metrics. We have developed an R package for identifying DC called Discordant which uses mixture models for correlations between features and the Expectation Maximization (EM) algorithm for fitting parameters of the mixture model. Several correlation metrics for sequencing data are provided and tested using simulations. Other extensions in the Discordant package include additional modeling for different types of differential correlation, and faster implementation, using a subsampling routine to reduce run-time and address the assumption of independence between molecular feature pairs. With simulations and breast cancer miRNA-Seq and RNA-Seq data, we find that Spearman's correlation has the best performance among the tested correlation methods for identifying differential correlation. Application of Spearman's correlation in the Discordant method demonstrated the most power in ROC curves and sensitivity/specificity plots, and improved ability to identify experimentally validated breast cancer miRNA. We also considered including additional types of differential correlation, which showed a slight reduction in power due to the additional parameters that need to be estimated, but more versatility in applications. Finally, subsampling within the EM algorithm considerably decreased run-time with negligible effect on performance. A new method and R package called Discordant is presented for identifying differential correlation with sequencing data. Based on comparisons with different correlation metrics, this study suggests Spearman's correlation is appropriate for sequencing data, but other correlation metrics are available to the user depending on the application and data type. The Discordant method can also be extended to investigate additional DC types and subsampling with the EM algorithm is now available for reduced run-time. These extensions to the R package make Discordant more robust and versatile for multiple -omics studies.

Effect of testing for cancer on cancer- and venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE.

PubMed

Robertson, Lindsay; Yeoh, Su Ern; Stansby, Gerard; Agarwal, Roshan

2017-08-23

Venous thromboembolism (VTE) is a collective term for two conditions: deep vein thrombosis (DVT) and pulmonary embolism (PE). A proportion of people with VTE have no underlying or immediately predisposing risk factors and the VTE is referred to as unprovoked. Unprovoked VTE can often be the first clinical manifestation of an underlying malignancy. This has raised the question of whether people with an unprovoked VTE should be investigated for an underlying cancer. Treatment for VTE is different in cancer and non-cancer patients and a correct diagnosis would ensure that people received the optimal treatment for VTE to prevent recurrence and further morbidity. Furthermore, an appropriate cancer diagnosis at an earlier, potentially curative stage could avoid the risk of cancer progression and thus lead to improvements in cancer-related mortality and morbidity. This is an update of a review first published in 2015. To determine whether testing for undiagnosed cancer in people with a first episode of unprovoked VTE (DVT of the lower limb or PE) is effective in reducing cancer and VTE-related mortality and morbidity and to determine which tests for cancer are best at identifying treatable cancers early. For this update, the Cochrane Vascular Information Specialist (CIS) searched the Specialised Register (16 February 2017). In addition, the CIS searched the Cochrane Register of Studies CENTRAL (2017, Issue 1). We searched trials registries (February 2017) and checked the reference lists of relevant articles. Randomised and quasi-randomised trials in which people with an unprovoked VTE were allocated to receive specific tests for cancer or clinically indicated tests only were eligible for inclusion in this review. Primary outcomes included all-cause mortality, cancer-related mortality and VTE-related mortality. Two review authors independently selected studies, assessed quality and extracted data. We resolved any disagreements by discussion. Four studies with 1644 participants met the inclusion criteria (two studies in the original review and two in this update). Two studies assessed the effect of extensive tests versus tests at the physician's discretion) while the other two studies assessed the effect of standard testing plus positron emission tomography (PET)/computed tomography (CT) scanning versus standard testing alone. For extensive tests versus tests at the physician's discretion, the quality of the evidence was low due to risk of bias (early termination of the studies). When comparing standard testing plus PET/CT scanning versus standard testing alone, the quality of evidence was moderate due to a risk of detection bias. The quality of the evidence was downgraded further when detection bias was present in one study with a low number of events.When comparing extensive tests versus tests at the physician's discretion, pooled analysis on two studies showed that testing for cancer was consistent with either a benefit or no benefit on cancer-related mortality (odds ratio (OR) 0.49, 95% confidence interval (CI) 0.15 to 1.67; 396 participants; 2 studies; P = 0.26; low quality evidence). One study (201 participants) showed that, overall, malignancies were less advanced in extensively tested participants than in participants in the control group. In total, 9/13 participants diagnosed with cancer in the extensively tested group had a T1 or T2 stage malignancy compared to 2/10 participants diagnosed with cancer in the control group (OR 5.00, 95% CI 1.05 to 23.76; P = 0.04; low quality evidence). There was no clear difference in detection of advanced stages between extensive tests versus tests at the physician's discretion: one participant in the extensively tested group had stage T3 compared with four participants in the control group (OR 0.25, 95% CI 0.03 to 2.28; P = 0.22; low quality evidence). In addition, extensively tested participants were diagnosed earlier than control group (mean: 1 month with extensive tests versus 11.6 months with tests at physician's discretion to cancer diagnosis from the time of diagnosis of VTE). Extensive testing did not increase the frequency of an underlying cancer diagnosis (OR 1.32, 95% CI 0.59 to 2.93; 396 participants; 2 studies; P = 0.50; low quality evidence). Neither study measured all-cause mortality, VTE-related morbidity and mortality, complications of anticoagulation, adverse effects of cancer tests, participant satisfaction or quality of life.When comparing standard testing plus PET/CT screening versus standard testing alone, standard testing plus PET/CT screening was consistent with either a benefit or no benefit on all-cause mortality (OR 1.22, 95% CI 0.49 to 3.04; 1248 participants; 2 studies; P = 0.66; moderate quality evidence), cancer-related mortality (OR 0.55, 95% CI 0.20 to 1.52; 1248 participants; 2 studies; P = 0.25; moderate quality evidence) or VTE-related morbidity (OR 1.02, 95% CI 0.48 to 2.17; 854 participants; 1 study; P = 0.96; moderate quality evidence). With regards to stage of cancer, there was no clear difference for detection of early (OR 1.78, 95% 0.51 to 6.17; 394 participants; 1 study; P = 0.37; low quality evidence) or advanced (OR 1.00, 95% CI 0.14 to 7.17; 394 participants; 1 study; P = 1.00; low quality evidence) stages of cancer. There was also no clear difference in the frequency of an underlying cancer diagnosis (OR 1.71, 95% CI 0.91 to 3.20; 1248 participants; 2 studies; P = 0.09; moderate quality evidence). Time to cancer diagnosis was 4.2 months in the standard testing group and 4.0 months in the standard testing plus PET/CT group (P = 0.88). Neither study measured VTE-related mortality, complications of anticoagulation, adverse effects of cancer tests, participant satisfaction or quality of life. Testing for cancer in people with unprovoked VTE may lead to earlier diagnosis of cancer at an earlier stage of the disease. However, there is currently insufficient evidence to draw definitive conclusions concerning the effectiveness of testing for undiagnosed cancer in people with a first episode of unprovoked VTE (DVT or PE) in reducing cancer and VTE-related morbidity and mortality. The results could be consistent with either benefit or no benefit. Further good-quality large-scale randomised controlled trials are required before firm conclusions can be made.

76 FR 57102 - Notice and Request for Comments: Two-Year Extension of Softwood Lumber Agreement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-15

... additional two years. The United States is considering extending the SLA through October 12, 2015. Interested... additional 2 years.'' Without an extension, the Agreement will expire in October 12, 2013. USTR is... for Comments: Two-Year Extension of Softwood Lumber Agreement AGENCY: Office of the United States...

Economic and Microbiologic Evaluation of Single-Dose Vial Extension for Hazardous Drugs

PubMed Central

Rowe, Erinn C.; Savage, Scott W.; Rutala, William A.; Weber, David J.; Gergen-Teague, Maria; Eckel, Stephen F.

2012-01-01

Purpose: The update of US Pharmacopeia Chapter <797> in 2008 included guidelines stating that single-dose vials (SDVs) opened and maintained in an International Organization for Standardization Class 5 environment can be used for up to 6 hours after initial puncture. A study was conducted to evaluate the cost of discarding vials after 6 hours and to further test sterility of vials beyond this time point, subsequently defined as the beyond-use date (BUD). Methods: Financial determination of SDV waste included 2 months of retrospective review of all doses prescribed. Additionally, actual waste log data were collected. Active and control vials (prepared using sterilized trypticase soy broth) were recovered, instead of discarded, at the defined 6-hour BUD. Results: The institution-specific waste of 19 selected SDV medications discarded at 6 hours was calculated at $766,000 annually, and tracking waste logs for these same medications was recorded at $770,000 annually. Microbiologic testing of vial extension beyond 6 hours showed that 11 (1.86%) of 592 samples had one colony-forming unit on one of two plates. Positive plates were negative at subsequent time points, and all positives were single isolates most likely introduced during the plating process. Conclusion: The cost of discarding vials at 6 hours was significant for hazardous medications in a large academic medical center. On the basis of microbiologic data, vial BUD extension demonstrated a contamination frequency of 1.86%, which likely represented exogenous contamination; vial BUD extension for the tested drugs showed no growth at subsequent time points and could provide an annual cost savings of more than $600,000. PMID:23180998

Development and evaluation of the impulse transfer function technique

NASA Technical Reports Server (NTRS)

Mantus, M.

1972-01-01

The development of the test/analysis technique known as the impulse transfer function (ITF) method is discussed. This technique, when implemented with proper data processing systems, should become a valuable supplement to conventional dynamic testing and analysis procedures that will be used in the space shuttle development program. The method can relieve many of the problems associated with extensive and costly testing of the shuttle for transient loading conditions. In addition, the time history information derived from impulse testing has the potential for being used to determine modal data for the structure under investigation. The technique could be very useful in determining the time-varying modal characteristics of structures subjected to thermal transients, where conventional mode surveys are difficult to perform.

Subscale Carbon-Carbon Nozzle Extension Development and Hot Fire Testing in Support of Upper Stage Liquid Rocket Engines

NASA Technical Reports Server (NTRS)

Gradl, Paul; Valentine, Peter; Crisanti, Matthew; Greene, Sandy Elam

2016-01-01

Upper stage and in-space liquid rocket engines are optimized for performance through the use of high area ratio nozzles to fully expand combustion gases to low exit pressures increasing exhaust velocities. Due to the large size of such nozzles and the related engine performance requirements, carbon-carbon (C/C) composite nozzle extensions are being considered for use in order to reduce weight impacts. NASA and industry partner Carbon-Carbon Advanced Technologies (C-CAT) are working towards advancing the technology readiness level of large-scale, domestically-fabricated, C/C nozzle extensions. These C/C extensions have the ability to reduce the overall costs of extensions relative to heritage metallic and composite extensions and to decrease weight by 50%. Material process and coating developments have advanced over the last several years, but hot fire testing to fully evaluate C/C nozzle extensions in relevant environments has been very limited. NASA and C-CAT have designed, fabricated and hot fire tested multiple subscale nozzle extension test articles of various C/C material systems, with the goal of assessing and advancing the manufacturability of these domestically producible materials as well as characterizing their performance when subjected to the typical environments found in a variety of liquid rocket and scramjet engines. Testing at the MSFC Test Stand 115 evaluated heritage and state-of-the-art C/C materials and coatings, demonstrating the capabilities of the high temperature materials and their fabrication methods. This paper discusses the design and fabrication of the 1.2k-lbf sized carbon-carbon nozzle extensions, provides an overview of the test campaign, presents results of the hot fire testing, and discusses potential follow-on development work.

A Testing Platform for Validation of Overhead Conductor Aging Models and Understanding Thermal Limits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Irminger, Philip; Starke, Michael R; Dimitrovski, Aleksandar D

2014-01-01

Power system equipment manufacturers and researchers continue to experiment with novel overhead electric conductor designs that support better conductor performance and address congestion issues. To address the technology gap in testing these novel designs, Oak Ridge National Laboratory constructed the Powerline Conductor Accelerated Testing (PCAT) facility to evaluate the performance of novel overhead conductors in an accelerated fashion in a field environment. Additionally, PCAT has the capability to test advanced sensors and measurement methods for accessing overhead conductor performance and condition. Equipped with extensive measurement and monitoring devices, PCAT provides a platform to improve/validate conductor computer models and assess themore » performance of novel conductors. The PCAT facility and its testing capabilities are described in this paper.« less

Incorporating Spatial Data into Enterprise Applications

NASA Astrophysics Data System (ADS)

Akiki, Pierre; Maalouf, Hoda

The main goal of this chapter is to discuss the usage of spatial data within enterprise as well as smaller line-of-business applications. In particular, this chapter proposes new methodologies for storing and manipulating vague spatial data and provides methods for visualizing both crisp and vague spatial data. It also provides a comparison between different types of spatial data, mainly 2D crisp and vague spatial data, and their respective fields of application. Additionally, it compares existing commercial relational database management systems, which are the most widely used with enterprise applications, and discusses their deficiencies in terms of spatial data support. A new spatial extension package called Spatial Extensions (SPEX) is provided in this chapter and is tested on a software prototype.

75 FR 20561 - Patent Term Extension

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

... drug products, medical devices, food additives, and color additives are eligible for extension. The... approved product, or a method of manufacturing the approved product. In addition, the application for... of manufacturing a product shall be extended if the term of the patent has not expired before an...

Testing sterile neutrino extensions of the Standard Model at future lepton colliders

NASA Astrophysics Data System (ADS)

Antusch, Stefan; Fischer, Oliver

2015-05-01

Extending the Standard Model (SM) with sterile ("right-handed") neutrinos is one of the best motivated ways to account for the observed neutrino masses. We discuss the expected sensitivity of future lepton collider experiments for probing such extensions. An interesting testable scenario is given by "symmetry protected seesaw models", which theoretically allow for sterile neutrino masses around the electroweak scale with up to order one mixings with the light (SM) neutrinos. In addition to indirect tests, e.g. via electroweak precision observables, sterile neutrinos with masses around the electroweak scale can also be probed by direct searches, e.g. via sterile neutrino decays at the Z pole, deviations from the SM cross section for four lepton final states at and beyond the WW threshold and via Higgs boson decays. We study the present bounds on sterile neutrino properties from LEP and LHC as well as the expected sensitivities of possible future lepton colliders such as ILC, CEPC and FCC-ee (TLEP).

Fly ash reinforced thermoplastic vulcanizates obtained from waste tire powder.

PubMed

Sridhar, V; Xiu, Zhang Zhen; Xu, Deng; Lee, Sung Hyo; Kim, Jin Kuk; Kang, Dong Jin; Bang, Dae-Suk

2009-03-01

Novel thermoplastic composites made from two major industrial and consumer wastes, fly ash and waste tire powder, have been developed. The effect of increasing fly ash loadings on performance characteristics such as tensile strength, thermal, dynamic mechanical and magnetic properties has been investigated. The morphology of the blends shows that fly ash particles have more affinity and adhesion towards the rubbery phase when compared to the plastic phase. The fracture surface of the composites shows extensive debonding of fly ash particles. Thermal analysis of the composites shows a progressive increase in activation energy with increase in fly ash loadings. Additionally, morphological studies of the ash residue after 90% thermal degradation shows extensive changes occurring in both the polymer and filler phases. The processing ability of the thermoplastics has been carried out in a Monsanto processability testing machine as a function of shear rate and temperature. Shear thinning behavior, typical of particulate polymer systems, has been observed irrespective of the testing temperatures. Magnetic properties and percolation behavior of the composites have also been evaluated.

Progress of Ongoing NASA Lithium-Ion Cell Verification Testing for Aerospace Applications

NASA Technical Reports Server (NTRS)

McKissock, Barbara I.; Manzo, Michelle A.; Miller, Thomas B.; Reid, Concha M.; Bennett, William R.; Gemeiner, Russel

2008-01-01

A Lithium-ion Verification and Validation Program with the purpose to assess the capabilities of current aerospace lithium-ion (Li-ion) battery cells to perform in a low-earth-orbit (LEO) regime was initiated in 2002. This program involves extensive characterization and LEO life testing at ten different combinations of depth-of-discharge, temperature, and end-of-charge voltage. The test conditions selected for the life tests are defined as part of a statistically designed test matrix developed to determine the effects of operating conditions on performance and life of Li-ion cells. Results will be used to model and predict cell performance and degradation as a function of test operating conditions. Testing is being performed at the Naval Surface Warfare Center/Crane Division in Crane, Indiana. Testing was initiated in September 2004 with 40 Ah cells from Saft and 30 Ah cells from Lithion. The test program has been expanded with the addition of modules composed of 18650 cells from ABSL Power Solutions in April 2006 and the addition of 50 Ah cells from Mine Safety Appliances Co. (MSA) in June 2006. Preliminary results showing the average voltage and average available discharge capacity for the Saft and Lithion packs at the test conditions versus cycles are presented.

Study on thermal effects & sulfurized additives, in lubricating greases

NASA Astrophysics Data System (ADS)

Shah, Ami Atul

Lithium Base grease constitutes about 50% of market. The greases are developed to be able to work in multiple working conditions and have longer working life. Greases with extreme pressure additives and anti-wear additives have been developed as a solution to many of the applications. These developed greases are tested under ASTM D2266 testing conditions to meet the requirements. The actual working conditions, although, differ than the real testing conditions. The loading, speed and temperature conditions can be more harsh, or fluctuating in nature. The cyclic nature of the parameters cannot be directly related to the test performance. For this purpose studies on the performance under spectrum loading, variable speed and fluctuating temperature must be performed. This study includes tests to understand the effect of thermal variation on some of the most commonly used grease additives that perform well under ASTM D2266 testing conditions. The studied additives include most widely used industrial extreme pressure additive MoS2. Performance of ZDDP which is trying to replace MoS2 in its industrial applications has also been studied. The tests cover study of extreme pressure, anti-wear and friction modifier additives to get a general idea on the effects of thermal variation in three areas. Sulphur is the most common extreme pressure additive. Sulphur based MoS 2 is extensively used grease additive. Study to understand the tribological performance of this additive through wear testing and SEM/EDX studies has been done. This performance is also studied for other metallic sulfides like WS2 and sulphur based organic compound. The aim is to study the importance of the type of bond that sulphur shares in its additive's structure on its performance. The MoS2 film formation is found to be on the basis of the FeS formation on the substrate and protection through sacrificial monolayer deposition of the MoS2 sheared structure. The free Mo then tends to oxidise. An attempt to understand the effects of the addition of sulphur from a sulfurized olefin to MoS2 through mechanical processing has been conducted. This mechanically processed additive mixed is tested through regular ASTM D2266 test. The hypothesis was to make more shear able MoS 2 layers available by using the sulphur from the olefin to form the basic FeS layer that reduces the continuous wear rate. The results have been studied using SEM and EDX imaging.

Fabrication and Testing of Low Cost 2D Carbon-Carbon Nozzle Extensions at NASA/MSFC

NASA Technical Reports Server (NTRS)

Greene, Sandra Elam; Shigley, John K.; George, Russ; Roberts, Robert

2015-01-01

Subscale liquid engine tests were conducted at NASA/MSFC using a 1.2 Klbf engine with liquid oxygen (LOX) and gaseous hydrogen. Testing was performed for main-stage durations ranging from 10 to 160 seconds at a chamber pressure of 550 psia and a mixture ratio of 5.7. Operating the engine in this manner demonstrated a new and affordable test capability for evaluating subscale nozzles by exposing them to long duration tests. A series of 2D C-C nozzle extensions were manufactured, oxidation protection applied and then tested on a liquid engine test facility at NASA/MSFC. The C-C nozzle extensions had oxidation protection applied using three very distinct methods with a wide range of costs and process times: SiC via Polymer Impregnation & Pyrolysis (PIP), Air Plasma Spray (APS) and Melt Infiltration. The tested extensions were about 6" long with an exit plane ID of about 6.6". The test results, material properties and performance of the 2D C-C extensions and attachment features will be discussed.

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.

PubMed

Aris, John P; Alvers, Ashley L; Ferraiuolo, Roy A; Fishwick, Laura K; Hanvivatpong, Amanda; Hu, Doreen; Kirlew, Christine; Leonard, Michael T; Losin, Kyle J; Marraffini, Michelle; Seo, Arnold Y; Swanberg, Veronica; Westcott, Jennifer L; Wood, Michael S; Leeuwenburgh, Christiaan; Dunn, William A

2013-10-01

We have previously shown that autophagy is required for chronological longevity in the budding yeast Saccharomyces cerevisiae. Here we examine the requirements for autophagy during extension of chronological life span (CLS) by calorie restriction (CR). We find that autophagy is upregulated by two CR interventions that extend CLS: water wash CR and low glucose CR. Autophagy is required for full extension of CLS during water wash CR under all growth conditions tested. In contrast, autophagy was not uniformly required for full extension of CLS during low glucose CR, depending on the atg allele and strain genetic background. Leucine status influenced CLS during CR. Eliminating the leucine requirement in yeast strains or adding supplemental leucine to growth media extended CLS during CR. In addition, we observed that both water wash and low glucose CR promote mitochondrial respiration proficiency during aging of autophagy-deficient yeast. In general, the extension of CLS by water wash or low glucose CR was inversely related to respiration deficiency in autophagy-deficient cells. Also, autophagy is required for full extension of CLS under non-CR conditions in buffered media, suggesting that extension of CLS during CR is not solely due to reduced medium acidity. Thus, our findings show that autophagy is: (1) induced by CR, (2) required for full extension of CLS by CR in most cases (depending on atg allele, strain, and leucine availability) and, (3) promotes mitochondrial respiration proficiency during aging under CR conditions. Copyright © 2013 Elsevier Inc. All rights reserved.

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast

PubMed Central

Aris, John P.; Alvers, Ashley L.; Ferraiuolo, Roy A.; Fishwick, Laura K.; Hanvivatpong, Amanda; Hu, Doreen; Kirlew, Christine; Leonard, Michael T.; Losin, Kyle J.; Marraffini, Michelle; Seo, Arnold Y.; Swanberg, Veronica; Westcott, Jennifer L.; Wood, Michael S.; Leeuwenburgh, Christiaan; Dunn, William A.

2013-01-01

We have previously shown that autophagy is required for chronological longevity in the budding yeast Saccharomyces cerevisiae. Here we examine the requirements for autophagy during extension of chronological life span (CLS) by calorie restriction (CR). We find that autophagy is upregulated by two CR interventions that extend CLS: water wash CR and low glucose CR. Autophagy is required for full extension of CLS during water wash CR under all growth conditions tested. In contrast, autophagy was not uniformly required for full extension of CLS during low glucose CR, depending on the atg allele and strain genetic background. Leucine status influenced CLS during CR. Eliminating the leucine requirement in yeast strains or adding supplemental leucine to growth media extended CLS during CR. In addition, we observed that both water wash and low glucose CR promote mitochondrial respiration proficiency during aging of autophagy-deficient yeast. In general, the extension of CLS by water wash or low glucose CR was inversely related to respiration deficiency in autophagy-deficient cells. Also, autophagy is required for full extension of CLS under non-CR conditions in buffered media, suggesting that extension of CLS during CR is not solely due to reduced medium acidity. Thus, our findings show that autophagy is: (1) induced by CR, (2) required for full extension of CLS by CR in most cases (depending on atg allele, strain, and leucine availability) and, (3) promotes mitochondrial respiration proficiency during aging under CR conditions. PMID:23337777

Item Parameter Changes and Equating: An Examination of the Effects of Lack of Item Parameter Invariance on Equating and Score Accuracy for Different Proficiency Levels

ERIC Educational Resources Information Center

Store, Davie

2013-01-01

The impact of particular types of context effects on actual scores is less understood although there has been some research carried out regarding certain types of context effects under the nonequivalent anchor test (NEAT) design. In addition, the issue of the impact of item context effects on scores has not been investigated extensively when item…

SPANISH PEAKS PRIMITIVE AREA, MONTANA.

USGS Publications Warehouse

Calkins, James A.; Pattee, Eldon C.

1984-01-01

A mineral survey of the Spanish Peaks Primitive Area, Montana, disclosed a small low-grade deposit of demonstrated chromite and asbestos resources. The chances for discovery of additional chrome resources are uncertain and the area has little promise for the occurrence of other mineral or energy resources. A reevaluation, sampling at depth, and testing for possible extensions of the Table Mountain asbestos and chromium deposit should be undertaken in the light of recent interpretations regarding its geologic setting.

Moment-rotation responses of the human lumbosacral spinal column.

PubMed

Guan, Yabo; Yoganandan, Narayan; Moore, Jason; Pintar, Frank A; Zhang, Jiangyue; Maiman, Dennis J; Laud, Purushottam

2007-01-01

The objective of this study was to test the hypothesis that the human lumbosacral joint behaves differently from L1-L5 joints and provides primary moment-rotation responses under pure moment flexion and extension and left and right lateral bending on a level-by-level basis. In addition, range of motion (ROM) and stiffness data were extracted from the moment-rotation responses. Ten T12-S1 column specimens with ages ranging from 27 to 68 years (mean: 50.6+/-13.2) were tested at a load level of 4.0 N m. Nonlinear flexion and extension and left and right lateral bending moment-rotation responses at each spinal level are reported in the form of a logarithmic function. The mean ROM was the greatest at the L5-S1 level under flexion (7.37+/-3.69 degrees) and extension (4.62+/-2.56 degrees) and at the L3-L4 level under lateral bending (4.04+/-1.11 degrees). The mean ROM was the least at the L1-L2 level under flexion (2.42+/-0.90 degrees), L2-L3 level under extension (1.58+/-0.63 degrees), and L1-L2 level under lateral bending (2.50+/-0.75 degrees). The present study proved the hypothesis that L5-S1 motions are significantly greater than L1-L5 motions under flexion and extension loadings, but the hypothesis was found to be untrue under the lateral bending mode. These experimental data are useful in the improved validation of FE models, which will increase the confidence of stress analysis and other modeling applications.

Fun During Knee Rehabilitation: Feasibility and Acceptability Testing of a New Android-Based Training Device

PubMed Central

Weber-Spickschen, Thomas Sanjay; Colcuc, Christian; Hanke, Alexander; Clausen, Jan-Dierk; James, Paul Abraham; Horstmann, Hauke

2017-01-01

Purpose: The initial goals of rehabilitation after knee injuries and operations are to achieve full knee extension and to activate quadriceps muscle. In addition to regular physiotherapy, an android-based knee training device is designed to help patients achieve these goals and improve compliance in the early rehabilitation period. This knee training device combines fun in a computer game with muscular training or rehabilitation. Our aim was to test the feasibility and acceptability of this new device. Methods: 50 volunteered subjects enrolled to test out the computer game aided device. The first game was the high-striker game, which recorded maximum knee extension power. The second game involved controlling quadriceps muscular power to simulate flying an aeroplane in order to record accuracy of muscle activation. The subjects evaluated this game by completing a simple questionnaire. Results: No technical problem was encountered during the usage of this device. No subjects complained of any discomfort after using this device. Measurements including maximum knee extension power, knee muscle activation and control were recorded successfully. Subjects rated their experience with the device as either excellent or very good and agreed that the device can motivate and monitor the progress of knee rehabilitation training. Conclusion: To the best of our knowledge, this is the first android-based tool available to fast track knee rehabilitation training. All subjects gave very positive feedback to this computer game aided knee device. PMID:29081870

Engineering and fabrication cost considerations for cryogenic wind tunnel models

NASA Technical Reports Server (NTRS)

Boykin, R. M., Jr.; Davenport, J. B., Jr.

1983-01-01

Design and fabrication cost drivers for cryogenic transonic wind tunnel models are defined. The major cost factors for wind tunnel models are model complexity, tolerances, surface finishes, materials, material validation, and model inspection. The cryogenic temperatures require the use of materials with relatively high fracture toughness but at the same time high strength. Some of these materials are very difficult to machine, requiring extensive machine hours which can add significantly to the manufacturing costs. Some additional engineering costs are incurred to certify the materials through mechanical tests and nondestructive evaluation techniques, which are not normally required with conventional models. When instrumentation such as accelerometers and electronically scanned pressure modules is required, temperature control of these devices needs to be incorporated into the design, which requires added effort. Additional thermal analyses and subsystem tests may be necessary, which also adds to the design costs. The largest driver to the design costs is potentially the additional static and dynamic analyses required to insure structural integrity of the model and support system.

Results of an independent evaluation of Project ALERT delivered in schools by Cooperative Extension.

PubMed

St Pierre, Tena L; Osgood, D Wayne; Mincemoyer, Claudia C; Kaltreider, D Lynne; Kauh, Tina J

2005-12-01

Reported are results of an independent effectiveness study of the Project ALERT drug prevention program implemented in eight Pennsylvania middle schools by outside program leaders employed by Cooperative Extension. In this randomized, 2-cohort longitudinal evaluation, 1,649 seventh-grade students completed a pretest and four waves of posttests over the 2-year program and 1-year follow-up. Project ALERT's effectiveness was tested through a 3-level hierarchical linear model. Analyses failed to yield any positive effects for substance use or mediators for use in the adult or teen-assisted delivery of the curriculum. An extensive set of additional analyses detected no differential program effects by student risk level, gender, school, or level of implementation quality. Potential explanations for outcomes relative to Project ALERT's original effectiveness trial are discussed, as well as implications for future research, including the need to conduct independent effectiveness studies of previously validated programs in a variety of contexts.

Hypothesis testing clarifies the systematics of the main Central American Chagas disease vector, Triatoma dimidiata (Latreille, 1811), across its geographic range.

PubMed

Dorn, Patricia L; de la Rúa, Nicholas M; Axen, Heather; Smith, Nicholas; Richards, Bethany R; Charabati, Jirias; Suarez, Julianne; Woods, Adrienne; Pessoa, Rafaela; Monroy, Carlota; Kilpatrick, C William; Stevens, Lori

2016-10-01

The widespread and diverse Triatoma dimidiata is the kissing bug species most important for Chagas disease transmission in Central America and a secondary vector in Mexico and northern South America. Its diversity may contribute to different Chagas disease prevalence in different localities and has led to conflicting systematic hypotheses describing various populations as subspecies or cryptic species. To resolve these conflicting hypotheses, we sequenced a nuclear (internal transcribed spacer 2, ITS-2) and mitochondrial gene (cytochrome b) from an extensive sampling of T. dimidiata across its geographic range. We evaluated the congruence of ITS-2 and cyt b phylogenies and tested the support for the previously proposed subspecies (inferred from ITS-2) by: (1) overlaying the ITS-2 subspecies assignments on a cyt b tree and, (2) assessing the statistical support for a cyt b topology constrained by the subspecies hypothesis. Unconstrained phylogenies inferred from ITS-2 and cyt b are congruent and reveal three clades including two putative cryptic species in addition to T. dimidiata sensu stricto. Neither the cyt b phylogeny nor hypothesis testing support the proposed subspecies inferred from ITS-2. Additionally, the two cryptic species are supported by phylogenies inferred from mitochondrially-encoded genes cytochrome c oxidase I and NADH dehydrogenase 4. In summary, our results reveal two cryptic species. Phylogenetic relationships indicate T. dimidiata sensu stricto is not subdivided into monophyletic clades consistent with subspecies. Based on increased support by hypothesis testing, we propose an updated systematic hypothesis for T. dimidiata based on extensive taxon sampling and analysis of both mitochondrial and nuclear genes. Copyright © 2016 Elsevier B.V. All rights reserved.

Shield evaluation and performance testing at the USMB`s Strategic Structures Testing Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barczak, T.M.; Gearhart, D.F.

1996-12-31

Historically, shield performance testing is conducted by the support manufacturers at European facilities. The U.S. Bureau of Mines (USBM) has conducted extensive research in shield Mechanics and is now opening its Strategic Structures Testing (SST) Laboratory to the mining industry for shield performance testing. The SST Laboratory provides unique shield testing capabilities using the Mine Roof Simulator (MRS) load frame. The MRS provides realistic and cost-effective shield evaluation by combining both vertical and horizontal loading into a single load cycle; whereas, several load cycles would be required to obtain this loading in a static frame. In addition to these advantages,more » the USBM acts as an independent research organization to provide an unbiased assessment of shield performance. This paper describes the USBM`s shield testing program that is designed specifically to simulate in-service mining conditions using the unique the capabilities of the SST Laboratory.« less

Association of Quadriceps Strength and Psychosocial Factors With Single-Leg Hop Performance in Patients With Meniscectomy.

PubMed

Hsu, Chao-Jung; George, Steven Z; Chmielewski, Terese L

2016-12-01

Clinicians use the single-leg hop test to assess readiness for return to sports after knee injury. Few studies have reported the results of single-leg hop testing after meniscectomy. Additionally, the contributions of impairments in quadriceps strength and psychosocial factors to single-leg hop performance are unknown. To compare single-leg hop performance (distance and landing mechanics) between limbs and to examine the association of single-leg hop performance with quadriceps strength and psychosocial factors in patients with meniscectomy. Descriptive laboratory study. A total of 22 subjects who underwent meniscectomy for traumatic meniscal tears received either standard rehabilitation alone or with additional quadriceps strengthening. Testing was conducted immediately postrehabilitation and at 1 year postsurgery. A single-leg hop test was performed bilaterally, and hop distance was used to create a hop symmetry index. Landing mechanics (peak knee flexion angle, knee extension moment, and peak vertical ground-reaction force) were analyzed with a motion-capture system and a force plate. An isokinetic dynamometer (60 deg/s) assessed knee extensor peak torque and rate of torque development (RTD 0-200ms and RTD 0-peak torque ). Questionnaires assessed fear of reinjury (Tampa Scale for Kinesiophobia [TSK-11]) and self-efficacy (Knee Activity Self-Efficacy [KASE]). Rehabilitation groups did not significantly differ in single-leg hop performance; therefore, groups were combined for further analyses. The mean hop symmetry index was 88.6% and 98.9% at postrehabilitation and 1 year postsurgery, respectively. Compared with the nonsurgical limb, the surgical limb showed decreased peak knee flexion angle at postrehabilitation and decreased knee extension moment at 1 year postsurgery. The hop symmetry index was positively associated with peak torque, RTD 0-200ms , and the KASE score at postrehabilitation. Moreover, at postrehabilitation, the peak knee flexion angle was positively associated with peak torque and RTD 0-200ms , and the knee extension moment was positively associated with RTD 0-200ms . At 1 year postsurgery, peak knee flexion angle and knee extension moment were both positively associated with peak torque, RTD 0-200ms , and RTD 0-peak torque . Although the hop symmetry index could be considered satisfactory for returning to sports, asymmetries in landing mechanics still exist in the first year postmeniscectomy. Greater quadriceps strength was associated with greater single-leg hop distance and better landing mechanics at both postrehabilitation and 1 year postsurgery. Knee activity self-efficacy was the only psychosocial factor associated with single-leg hop performance and isolated to a positive association with single-leg hop distance at postrehabilitation. Rate of development is not typically measured in the clinic but can be an additional quadriceps measure to monitor for single-leg hop performance. Quadriceps strength and psychosocial factors appear to have separate influence on single-leg hop performance after meniscectomy, which has implications for developing appropriate interventions for optimal single-leg hop performance.

Association of Quadriceps Strength and Psychosocial Factors With Single-Leg Hop Performance in Patients With Meniscectomy

PubMed Central

Hsu, Chao-Jung; George, Steven Z.; Chmielewski, Terese L.

2016-01-01

Background: Clinicians use the single-leg hop test to assess readiness for return to sports after knee injury. Few studies have reported the results of single-leg hop testing after meniscectomy. Additionally, the contributions of impairments in quadriceps strength and psychosocial factors to single-leg hop performance are unknown. Purpose: To compare single-leg hop performance (distance and landing mechanics) between limbs and to examine the association of single-leg hop performance with quadriceps strength and psychosocial factors in patients with meniscectomy. Study Design: Descriptive laboratory study. Methods: A total of 22 subjects who underwent meniscectomy for traumatic meniscal tears received either standard rehabilitation alone or with additional quadriceps strengthening. Testing was conducted immediately postrehabilitation and at 1 year postsurgery. A single-leg hop test was performed bilaterally, and hop distance was used to create a hop symmetry index. Landing mechanics (peak knee flexion angle, knee extension moment, and peak vertical ground-reaction force) were analyzed with a motion-capture system and a force plate. An isokinetic dynamometer (60 deg/s) assessed knee extensor peak torque and rate of torque development (RTD0-200ms and RTD0–peak torque). Questionnaires assessed fear of reinjury (Tampa Scale for Kinesiophobia [TSK-11]) and self-efficacy (Knee Activity Self-Efficacy [KASE]). Results: Rehabilitation groups did not significantly differ in single-leg hop performance; therefore, groups were combined for further analyses. The mean hop symmetry index was 88.6% and 98.9% at postrehabilitation and 1 year postsurgery, respectively. Compared with the nonsurgical limb, the surgical limb showed decreased peak knee flexion angle at postrehabilitation and decreased knee extension moment at 1 year postsurgery. The hop symmetry index was positively associated with peak torque, RTD0-200ms, and the KASE score at postrehabilitation. Moreover, at postrehabilitation, the peak knee flexion angle was positively associated with peak torque and RTD0-200ms, and the knee extension moment was positively associated with RTD0-200ms. At 1 year postsurgery, peak knee flexion angle and knee extension moment were both positively associated with peak torque, RTD0-200ms, and RTD0–peak torque. Conclusion: Although the hop symmetry index could be considered satisfactory for returning to sports, asymmetries in landing mechanics still exist in the first year postmeniscectomy. Greater quadriceps strength was associated with greater single-leg hop distance and better landing mechanics at both postrehabilitation and 1 year postsurgery. Knee activity self-efficacy was the only psychosocial factor associated with single-leg hop performance and isolated to a positive association with single-leg hop distance at postrehabilitation. Clinical Relevance: Rate of development is not typically measured in the clinic but can be an additional quadriceps measure to monitor for single-leg hop performance. Quadriceps strength and psychosocial factors appear to have separate influence on single-leg hop performance after meniscectomy, which has implications for developing appropriate interventions for optimal single-leg hop performance. PMID:28210647

A best practice fall prevention exercise program to improve balance, strength / power, and psychosocial health in older adults: study protocol for a randomized controlled trial.

PubMed

Gschwind, Yves J; Kressig, Reto W; Lacroix, Andre; Muehlbauer, Thomas; Pfenninger, Barbara; Granacher, Urs

2013-10-09

With increasing age neuromuscular deficits (e.g., sarcopenia) may result in impaired physical performance and an increased risk for falls. Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline. Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. Additionally, the time-related effects of detraining are tested. Healthy old people (n = 54) between the age of 65 to 80 years will participate in this trial. The testing protocol comprises tests for the assessment of static / dynamic steady-state balance (i.e., Sharpened Romberg Test, instrumented gait analysis), proactive balance (i.e., Functional Reach Test; Timed Up and Go Test), reactive balance (i.e., perturbation test during bipedal stance; Push and Release Test), strength (i.e., hand grip strength test; Chair Stand Test), and power (i.e., Stair Climb Power Test; countermovement jump). Further, body composition will be analysed using a bioelectrical impedance analysis system. In addition, questionnaires for the assessment of psychosocial (i.e., World Health Organisation Quality of Life Assessment-Bref), cognitive (i.e., Mini Mental State Examination), and fall risk determinants (i.e., Fall Efficacy Scale - International) will be included in the study protocol. Participants will be randomized into two intervention groups or the control / waiting group. After baseline measures, participants in the intervention groups will conduct a 12-week balance and strength / power exercise intervention 3 times per week, with each training session lasting 30 min. (actual training time). One intervention group will complete an extensive supervised training program, while the other intervention group will complete a short version ('3 times 3') that is home-based and controlled by weekly phone calls. Post-tests will be conducted right after the intervention period. Additionally, detraining effects will be measured 12 weeks after program cessation. The control group / waiting group will not participate in any specific intervention during the experimental period, but will receive the extensive supervised program after the experimental period. It is expected that particularly the supervised combination of balance and strength / power training will improve performance in variables of balance, strength / power, body composition, cognitive function, psychosocial well-being, and falls self-efficacy of older adults. In addition, information regarding fall risk assessment, dose-response-relations, detraining effects, and supervision of training will be provided. Further, training-induced health-relevant changes, such as improved performance in activities of daily living, cognitive function, and quality of life, as well as a reduced risk for falls may help to lower costs in the health care system. Finally, practitioners, therapists, and instructors will be provided with a scientifically evaluated feasible, safe, and easy-to-administer exercise program for fall prevention.

Statistical Analysis of Compressive and Flexural Test Results on the Sustainable Adobe Reinforced with Steel Wire Mesh

NASA Astrophysics Data System (ADS)

Jokhio, Gul A.; Syed Mohsin, Sharifah M.; Gul, Yasmeen

2018-04-01

It has been established that Adobe provides, in addition to being sustainable and economic, a better indoor air quality without spending extensive amounts of energy as opposed to the modern synthetic materials. The material, however, suffers from weak structural behaviour when subjected to adverse loading conditions. A wide range of mechanical properties has been reported in literature owing to lack of research and standardization. The present paper presents the statistical analysis of the results that were obtained through compressive and flexural tests on Adobe samples. Adobe specimens with and without wire mesh reinforcement were tested and the results were reported. The statistical analysis of these results presents an interesting read. It has been found that the compressive strength of adobe increases by about 43% after adding a single layer of wire mesh reinforcement. This increase is statistically significant. The flexural response of Adobe has also shown improvement with the addition of wire mesh reinforcement, however, the statistical significance of the same cannot be established.

Study of flow stress and spall strength of additively manufactured Ti-6-4 alloy

NASA Astrophysics Data System (ADS)

Cohen, Amitay; Paris, Vitaly; Yosef-Hai, Arnon; Gudinetsky, Eli; Tiferet, Eitan

2017-06-01

The use of additive manufacturing (AM) by Electron Beam Melting (EBM) or Selective Laser Melting (SLM) has extensively grown in the past few years. A major goal in AM is to manufacture materials with mechanical properties at least as good as traditionally manufactured materials. In this work we present results of planar impact tests and Split Hopkinson Pressure Bar tests (SHPB) on Ti-6-4 manufactured by EBM and SLM processes. Results of planar impact tests on SLM samples display slightly higher spall strength compared to EBM while the stress at Hugoniot elastic limit (HEL) is practically the same. Stress strain curves based on SHPB measurements at two different strain rates present similar plastic flow stresses for SLM and EBM processed Ti-6-4 alloy, while the flow stress is about 20% higher than reported for commercial reference material. The strain to failure of both materials shows considerable strain rate sensitivity. The results of post-mortem analysis of spall fracture will also be presented.

Triaminoguanidinium dinitramide-calculations, synthesis and characterization of a promising energetic compound.

PubMed

Klapötke, Thomas M; Stierstorfer, Jörg

2008-08-07

The highly energetic compound 1,3,5-triaminoguanidinium dinitramide (1) was prepared in high yield (82%) according to a new synthesis by the reaction of potassium dinitramide and triaminoguanidinium perchlorate. The heat of formation was calculated in an extensive computational study (CBS-4M). With this the detonation parameters of compound were computed using the EXPLO5 software: D = 8796 m s(-1), p = 299 kbar. In addition, a full characterization of the chemical properties (single X-ray diffraction, IR and Raman spectroscopy, multinuclear NMR spectroscopy, mass spectrometry and elemental analysis) as well as of the energetic characteristics (differential scanning calorimetry, thermal safety calorimetry, impact, friction and electrostatic tests) is given in this work. Due to the high impact (2 J) and friction sensitivity (24 N) several attempts to reduce these sensitivities were performed by the addition of wax. The performance of was tested applying a "Koenen" steel sleeve test resulting in a critical diameter of > or =10 mm.

Microdevice for plasma separation from whole human blood using bio-physical and geometrical effects

PubMed Central

Tripathi, Siddhartha; Kumar, Y. V. BalaVarun; Agrawal, Amit; Prabhakar, Amit; Joshi, Suhas S.

2016-01-01

In this research work, we present a simple and efficient passive microfluidic device for plasma separation from pure blood. The microdevice has been fabricated using conventional photolithography technique on a single layer of polydimethylsiloxane, and has been extensively tested on whole blood and enhanced (upto 62%) hematocrit levels of human blood. The microdevice employs elevated dimensions of about 100 μm; such elevated dimensions ensure clog-free operation of the microdevice and is relatively easy to fabricate. We show that our microdevice achieves almost 100% separation efficiency on undiluted blood in the flow rate range of 0.3 to 0.5 ml/min. Detailed biological characterization of the plasma obtained from the microdevice is carried out by testing: proteins by ultra-violet spectrophotometric method, hCG (human chorionic gonadotropin) hormone, and conducting random blood glucose test. Additionally, flow cytometry study has also been carried on the separated plasma. These tests attest to the high quality of plasma recovered. The microdevice developed in this work is an outcome of extensive experimental research on understanding the flow behavior and separation phenomenon of blood in microchannels. The microdevice is compact, economical and effective, and is particularly suited in continuous flow operations. PMID:27279146

Aligning, Bonding, and Testing Mirrors for Lightweight X-ray Telescopes

NASA Technical Reports Server (NTRS)

Chan, Kai-Wing; Zhang, William W.; Saha, Timo T.; McClelland, Ryan S.; Biskach, Michael P.; Niemeyer, Jason; Schofield, Mark J.; Mazzarella, James R.; Kolos, Linette D.; Hong, Melinda M.;

75 FR 30392 - Transparency Provisions of Section 23 of the Natural Gas Act; Notice of Extension of Time

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... Provisions of Section 23 of the Natural Gas Act; Notice of Extension of Time May 24, 2010. In comments... additional time will allow filers to prepare the Form No. 552 based on any additional guidance that the... consideration, notice is hereby given that all natural gas market participants are granted an extension of time...

Integrated Cryogenic Electronics Testbed (ICE-T) for Evaluation of Superconductor and Cryo-Semiconductor Integrated Circuits

NASA Astrophysics Data System (ADS)

Dotsenko, V. V.; Sahu, A.; Chonigman, B.; Tang, J.; Lehmann, A. E.; Gupta, V.; Talalevskii, A.; Ruotolo, S.; Sarwana, S.; Webber, R. J.; Gupta, D.

2017-02-01

Research and development of cryogenic application-specific integrated circuits (ASICs), such as high-frequency (tens of GHz) semiconductor and superconductor mixed-signal circuits and large-scale (>10,000 Josephson Junctions) superconductor digital circuits, have long been hindered by the absence of specialized cryogenic test apparatus. During their iterative development phase, most ASICs require many additional input-output lines for applying independent bias controls, injecting test signals, and monitoring outputs of different sub-circuits. We are developing a full suite of modular test apparatus based on cryocoolers that do not consume liquid helium, and support extensive electrical interfaces to standard and custom test equipment. Our design separates the cryogenics from electrical connections, allowing even inexperienced users to conduct testing by simply mounting their ASIC on a removable electrical insert. Thermal connections between the cold stages and the inserts are made with robust thermal links. ICE-T accommodates two independent electrical inserts at the same time. We have designed various inserts, such as universal ones with all 40 or 80 coaxial cables and those with customized wiring and temperature-controlled stages. ICE-T features fast thermal cycling for rapid testing, enables detailed testing over long periods (days to months, if necessary), and even supports automated testing of digital ICs with modular additions.

7 CFR 1717.603 - RUS approval of extensions and additions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the acquisition or start of construction. (b) Power supply borrowers. Prior written approval by RUS is required for a power supply borrower to extend or add to its electric system if the extension or addition...

Metastability in plyometric training on unstable surfaces: a pilot study

PubMed Central

2014-01-01

Background In the past, plyometric training (PT) has been predominantly performed on stable surfaces. The purpose of this pilot study was to examine effects of a 7-week lower body PT on stable vs. unstable surfaces. This type of exercise condition may be denoted as metastable equilibrium. Methods Thirty-three physically active male sport science students (age: 24.1 ± 3.8 years) were randomly assigned to a PT group (n = 13) exercising on stable (STAB) and a PT group (n = 20) on unstable surfaces (INST). Both groups trained countermovement jumps, drop jumps, and practiced a hurdle jump course. In addition, high bar squats were performed. Physical fitness tests on stable surfaces (hexagonal obstacle test, countermovement jump, hurdle drop jump, left-right hop, dynamic and static balance tests, and leg extension strength) were used to examine the training effects. Results Significant main effects of time (ANOVA) were found for the countermovement jump, hurdle drop jump, hexagonal test, dynamic balance, and leg extension strength. A significant interaction of time and training mode was detected for the countermovement jump in favor of the INST group. No significant improvements were evident for either group in the left-right hop and in the static balance test. Conclusions These results show that lower body PT on unstable surfaces is a safe and efficient way to improve physical performance on stable surfaces. PMID:25089202

Nonlinear Solver Approaches for the Diffusive Wave Approximation to the Shallow Water Equations

NASA Astrophysics Data System (ADS)

Collier, N.; Knepley, M.

2015-12-01

The diffusive wave approximation to the shallow water equations (DSW) is a doubly-degenerate, nonlinear, parabolic partial differential equation used to model overland flows. Despite its challenges, the DSW equation has been extensively used to model the overland flow component of various integrated surface/subsurface models. The equation's complications become increasingly problematic when ponding occurs, a feature which becomes pervasive when solving on large domains with realistic terrain. In this talk I discuss the various forms and regularizations of the DSW equation and highlight their effect on the solvability of the nonlinear system. In addition to this analysis, I present results of a numerical study which tests the applicability of a class of composable nonlinear algebraic solvers recently added to the Portable, Extensible, Toolkit for Scientific Computation (PETSc).

Implementation analysis of RC5 algorithm on Preneel-Govaerts-Vandewalle (PGV) hashing schemes using length extension attack

NASA Astrophysics Data System (ADS)

Siswantyo, Sepha; Susanti, Bety Hayat

2016-02-01

Preneel-Govaerts-Vandewalle (PGV) schemes consist of 64 possible single-block-length schemes that can be used to build a hash function based on block ciphers. For those 64 schemes, Preneel claimed that 4 schemes are secure. In this paper, we apply length extension attack on those 4 secure PGV schemes which use RC5 algorithm in its basic construction to test their collision resistance property. The attack result shows that the collision occurred on those 4 secure PGV schemes. Based on the analysis, we indicate that Feistel structure and data dependent rotation operation in RC5 algorithm, XOR operations on the scheme, along with selection of additional message block value also give impact on the collision to occur.

Development of protocols for confined extension/creep testing of geosynthetics for highway applications

DOT National Transportation Integrated Search

1998-03-01

This report presents the development and verification of a testing protocol and protocol equipment for confined extension testing and confined creep testing for geosynthetic reinforcement materials. The developed data indicate that confined response ...

Extension and Validation of a Hybrid Particle-Finite Element Method for Hypervelocity Impact Simulation. Chapter 2

NASA Technical Reports Server (NTRS)

Fahrenthold, Eric P.; Shivarama, Ravishankar

2004-01-01

The hybrid particle-finite element method of Fahrenthold and Horban, developed for the simulation of hypervelocity impact problems, has been extended to include new formulations of the particle-element kinematics, additional constitutive models, and an improved numerical implementation. The extended formulation has been validated in three dimensional simulations of published impact experiments. The test cases demonstrate good agreement with experiment, good parallel speedup, and numerical convergence of the simulation results.

NASA's International Lunar Network Anchor Nodes and Robotic Lunar Lander Project Update

NASA Technical Reports Server (NTRS)

Cohen, Barbara A.; Bassler, Julie A.; Ballard, Benjamin; Chavers, Greg; Eng, Doug S.; Hammond, Monica S.; Hill, Larry A.; Harris, Danny W.; Hollaway, Todd A.; Kubota, Sanae;

Addition of Olfactory Stimuli to Virtual Reality Simulations for Medical Training Applications

DTIC Science & Technology

1996-11-01

surveyed and a working set of odorants were indentified or developed in sufficient quantities to support further testing. Extensive studies were performed...Olfactory Displays for HMD Systems 8 Ambulatory Olfactory HMD Display 11 Odor Display--Booth Environment 19 Odor Display in CAVE 20 Odor Survey and Odor...HMDs, it may be welcome in some scenarios such as those that might be used for training medics. Odorant Survey and Odor Development A second area of

Strength improvements through occlusal splints? The effects of different lower jaw positions on maximal isometric force production and performance in different jumping types

PubMed Central

Maurer, Christian; Heller, Sebastian; Sure, Jil-Julia; Fuchs, Daniel; Mickel, Christoph; Wanke, Eileen M.; Groneberg, David A.

2018-01-01

Objective The influence of the jaw position on postural control, body posture, walking and running pattern has been reported in the literature. All these movements have in common that a relatively small, but well controlled muscle activation is required. The induced effects on motor output through changed jaw positions have been small. Therefore, it has been questioned if it could still be observed in maximal muscle activation. Method Twenty-three healthy, mid age recreational runners (mean age = 34.0 ± 10.3 years) participated in this study. Three different jump tests (squat jump, counter movement jump, and drop jumps from four different heights) and three maximal strength tests (trunk flexion and extension, leg press of the right and left leg) were conducted. Four different dental occlusion conditions and an additional familiarization condition were tested. Subjects performed the tests on different days for which the four occlusion conditions were randomly changed. Results No familiarization effect was found. Occlusion conditions with a relaxation position and with a myocentric condylar position showed significantly higher values for several tests compared to the neutral condition and the maximal occlusion position. Significance was found in the squat jump, countermovement jump, the drop jump from 32cm and 40cm, trunk extension, leg press force and rate of force development. The effect due to the splint conditions is an improvement between 3% and 12% (min and max). No influence of the jaw position on symmetry or balance between extension and flexion muscle was found. Conclusion An influence of occlusion splints on rate of force development (RFD) and maximal strength tests could be confirmed. A small, but consistent increase in the performance parameters could be measured. The influence of the occlusion condition is most likely small compared to other influences as for example training status, age, gender and circadian rhythm. PMID:29474465

Explosion Amplitude Reduction due to Fractures in Water-Saturated and Dry Granite

NASA Astrophysics Data System (ADS)

Stroujkova, A. F.; Leidig, M.; Bonner, J. L.

2013-12-01

Empirical observations made at the Semipalatinsk Test Site suggest that nuclear tests in the fracture zones left by previous explosions ('repeat shots') show reduced seismic amplitudes compared to the nuclear tests in virgin rocks. Likely mechanisms for the amplitude reduction in the repeat shots include increased porosity and reduced strength and elastic moduli, leading to pore closing and frictional sliding. Presence of pore water significantly decreases rock compressibility and strength, thus affecting seismic amplitudes. A series of explosion experiments were conducted in order to define the physical mechanism responsible for the amplitude reduction and to quantify the degree of the amplitude reduction in fracture zones of previously detonated explosions. Explosions in water-saturated granite were conducted in central New Hampshire in 2011 and 2012. Additional explosions in dry granite were detonated in Barre, VT in 2013. The amplitude reduction is different between dry and water-saturated crystalline rocks. Significant reduction in seismic amplitudes (by a factor of 2-3) in water-saturated rocks was achieved only when the repeat shot was detonated in the extensive damage zone created by a significantly larger (by a factor of 5) explosion. In case where the first and the second explosions were similar in yield, the amplitude reduction was relatively modest (5-20%). In dry rocks the amplitude reduction reached a factor of 2 even in less extensive damage zones. In addition there are differences in frequency dependence of the spectral amplitude ratios between explosions in dry and water-saturated rocks. Thus the amplitude reduction is sensitive to the extent of the damage zone as well as the pore water content.

Post Processing Methods used to Improve Surface Finish of Products which are Manufactured by Additive Manufacturing Technologies: A Review

NASA Astrophysics Data System (ADS)

Kumbhar, N. N.; Mulay, A. V.

2016-08-01

The Additive Manufacturing (AM) processes open the possibility to go directly from Computer-Aided Design (CAD) to a physical prototype. These prototypes are used as test models before it is finalized as well as sometimes as a final product. Additive Manufacturing has many advantages over the traditional process used to develop a product such as allowing early customer involvement in product development, complex shape generation and also save time as well as money. Additive manufacturing also possess some special challenges that are usually worth overcoming such as Poor Surface quality, Physical Properties and use of specific raw material for manufacturing. To improve the surface quality several attempts had been made by controlling various process parameters of Additive manufacturing and also applying different post processing techniques on components manufactured by Additive manufacturing. The main objective of this work is to document an extensive literature review in the general area of post processing techniques which are used in Additive manufacturing.

Ecotoxicity of wastes in avoidance tests with Enchytraeus albidus, Enchytraeus crypticus and Eisenia fetida (Oligochaeta).

PubMed

Kobeticová, Klára; Hofman, Jakub; Holoubek, Ivan

2010-04-01

Contact bioassays are important for testing the ecotoxicity of solid materials. However, survival and reproduction tests are often not practical due to their duration which may last for several weeks. Avoidance tests with soil invertebrates may offer an alternative or extension to the classic test batteries due to their short duration (days rather than weeks) and due to a sensitive sub-acute endpoint (behavior). (a) to evaluate the effects of three solid industrial wastes (incineration ash, contaminated wood chips and contaminated soil) on three Oligochaeta species (enchytraeids Enchytraeusalbidus, Enchytraeus crypticus and earthworm Eisenia fetida) in avoidance tests; (b) to compare the sensitivity among the species and to compare results of avoidance test to reproduction tests; (c) to elucidate if measuring the weight in the earthworm avoidance test could be reasonable additional endpoint. Avoidance mostly increased with the increasing percent of waste in the mixture showing a dose-response curve. E. fetida was the most sensitive species and E. crypticus the least one. An additional endpoint, (changes in weight after two-day exposure) was not found to be more sensitive than avoidance reaction, but it confirmed that earthworms staying in the highest concentrations of the waste mixture were affected showing apparent weight reduction. Our results indicate that avoidance tests with earthworms and enchytraeids are feasible for waste testing. Copyright 2009 Elsevier Ltd. All rights reserved.

Performance documentation of the engineering model 30-cm diameter thruster

NASA Technical Reports Server (NTRS)

Bechtel, R. T.; Rawlin, V. K.

1976-01-01

The results of extensive testing of two 30-cm ion thrusters which are virtually identical to the 900 series Engineering Model Thruster in an ongoing 15,000-hour life test are presented. Performance data for the nominal fullpower (2650 W) operating point; performance sensitivities to discharge voltage, discharge losses, accelerator voltage, and magnetic baffle current; and several power throttling techniques (maximum Isp, maximum thrust/power ratio, and two cases in between are included). Criteria for throttling are specified in terms of the screen power supply envelope, thruster operating limits, and control stability. In addition, reduced requirements for successful high voltage recycles are presented.

Reuse fo a Cold War Surveillance Drone to Flight Test a NASA Rocket Based Combined Cycle Engine

NASA Technical Reports Server (NTRS)

Brown, T. M.; Smith, Norm

1999-01-01

Plans for and early feasibility investigations into the modification of a Lockheed D21B drone to flight test the DRACO Rocket Based Combined Cycle (RBCC) engine are discussed. Modifications include the addition of oxidizer tanks, modern avionics systems, actuators, and a vehicle recovery system. Current study results indicate that the D21B is a suitable candidate for this application and will allow demonstrations of all DRACO engine operating modes at Mach numbers between 0.8 and 4.0. Higher Mach numbers may be achieved with more extensive modification. Possible project risks include low speed stability and control, and recovery techniques.

The development of a non-cryogenic nitrogen/oxygen supply system

NASA Technical Reports Server (NTRS)

Greenough, B. M.

1972-01-01

Development of the hydrazine/water electrolysis process in a manned spacecraft to provide metabolic oxygen and both oxygen and nitrogen for cabin leakage makeup was studied. Electrode development efforts were directed to stability, achieved with catalyst additives and improved processing techniques, and a higher hydrazine conversion efficiency, achieved by reducing catalyst loading on the cathodes. Extensive testing of the one-man breadboard N2/02 system provided complete characterization of cabin atmosphere control aspects. A detailed design of a prototype modular N2/02 unit was conducted. The contact heat exchanger which is an integral component of this design was fabricated and sucessfully design-verification tested.

Testing relativity with orbiting clocks

NASA Astrophysics Data System (ADS)

Nissen, J. A.; Lipa, J. A.; Wang, S.; Avaloff, D.; Stricker, D. A.

2011-02-01

We describe the background and status of a superconducting microwave clock suitable for relativity experiments in earth orbit. The project has the capability of performing improved tests of Lorentz invariance via a Michelson-Morley type experiment, and setting new limits on nine parameters in the Standard Model Extension. If flown with a high stability atomic clock, a Kennedy-Thorndike experiment along with additional tests in general relativity could be performed.In orbit, unwanted cavity frequency variations are expected to be caused mainly by acceleration effects due to residual drag and vibration, temperature variations, and fluctuations in the energy stored in the cavity. A cavity support system has been designed to reduce acceleration effects and a high resolution thermometer has been implemented to improve temperature control.

Evaluation of EDR-3 vibration, shock, temperature, and humidity recording unit

NASA Technical Reports Server (NTRS)

Rees, Kevin G.; Mondale, C. F.

1990-01-01

The purpose of this evaluation was to determine if the self-contained, off-the-shelf, Environmental Data Recorder 3 (EDR-3) could be qualified to monitor shock, vibration, and temperature during rail transportation of space shuttle solid rocket components. The evaluation testing started in November 1989 and continued until June 1990. Two EDR-3 units were used to monitor both on- and off-plant shipments of shuttle components. In addition, extensive testing was performed at Thiokol's Vibration Test facility, T-53. Testing demonstrated that the EDR-3 is capable of successfully monitoring actual shipments of solid rocket hardware. Thiokol metrology has verified the accuracy of temperature monitoring. In addition, calibrated shock/vibration testing demonstrated that the EDR-3 does accurately record acceleration. It is recommended that the vendor modify the EDR-3 data recovery system to allow remote communication via a 30-foot cable. This would permit communication with the unit mounted on a case segment after a rail car cover is installed. The vendor will make this change and produce a new model, designated EDR-3-10. It is further recommended that Thiokol qualify the EDR-3-10 for transportation monitoring of redesigned solid rocket motor (RSRM) components.

Effect of Microstructure on the Mechanical Properties of Extruded Magnesium and a Magnesium Alloy

NASA Astrophysics Data System (ADS)

McGhee, Paul

The main objective of this research was to investigate the relationship between the fatigue behavior and crystallographic texture evolution of magnesium (Mg) alloys with a range of microalloying element content processed under various extrusion conditions. Several Mg alloys were processed under a range of extrusion temperatures, extrusion ratios, and alloying content and tested under monotonic and cyclic fatigue loading conditions: fully-reversed condition tested at strain amplitudes of 0.15% - 1.00% in strain-control mode. After fatigue testing, Mg microstructural analysis was performed using SEM, TEM, optical microscopy, and X-ray diffraction techniques. Microstructural observations revealed significant grain refinement through a combination of zirconium (Zr) addition and hot-extrusion, producing fine equiaxed grain structure with grain sizes ranging between 1-5 microm. Texture analysis and partial compression testing results showed that the initial texture of the extruded alloy gradually evolved upon compressive loading along the c-axes inducing extension twinning creating a strong basal texture along the extrusion direction. Full tensile and compression testing at room temperature showed that the combination of hot extrusion and Zr addition can further refine the grains of the Mg alloys microstructure and enhance the texture while simultaneously enhancing the mechanical properties.

Continuous and pulsed laser high power beam combiner for additive manufacturing applications

NASA Astrophysics Data System (ADS)

Bassignana, Marta; Califano, Alessio; Pescarmona, Francesco; Braglia, Andrea; Perrone, Guido

2018-02-01

Laser-based additive manufacturing (AM) from metal powders is emerging as the new industrial revolution, although current fabrication approaches still require long mechanical post-processing to improve the final surface quality and meet the design tolerances. To overcome this limitation, the next generation machines are expected to complement laser AM with laser ablation (LA) to implement surface finishing and micro texturing already during the device growth process. With this aim, a new beam combiner to allow the real-time interchange of additive and subtractive processes using the same scanner head has been designed. Extensive tests have been carried out using a 6 kW continuous-wave laser similar to that used for the metal powder fusion and a nanosecond 100W pulsed source similar to that used for laser ablation.

Division File of Extension Research Materials; Additions During 1968.

ERIC Educational Resources Information Center

Byrn, Darcie, Comp.

In this annotated bibliography of acquisitions during 1968 appear 265 Extension studies on administrative organization and management; training and staff development; mobilizing participation in Extension work; local leadership; program content and planning procedures; general effectiveness and progress in Extension; teaching methods, techniques,…

Occult cancer detection in patients with hemostatic disorder and venous thromboembolism.

PubMed

Husseinzadeh, Holleh; Carrier, Marc

2018-03-01

There are physiologic ties between Von Willebrand Factor (VWF) and circulating tumor cells. VWF appears to play a role in tumor biology, but it is unclear whether cancer behavior differs in Von Willebrand Disease. In patients presenting with venous thromboembolism (VTE), occult cancer is frequently considered as an underlying cause. The prevalence of occult cancer after provoked VTE is low (3%); therefore, cancer screening in these patients is not routinely recommended. In those with unprovoked VTE, occult cancer is more prevalent, estimated between 4 and 10%. Due to this elevated risk, occult cancer screening is recommended in this population. Multiple studies have investigated whether a "limited" approach (including history and physical exam, basic labs, and chest X-ray) versus "extensive" approach (addition of advanced imaging, such as computer tomography) is more effective. Current data fails to demonstrate extensive screening strategies diagnose more occult cancer, miss fewer cancers during follow up, or improve cancer-related mortality. Furthermore, many patients may be needlessly exposed to unnecessary diagnostic procedures with their associated complications and costs, as well as significant anxiety. Therefore, the decision to perform additional testing should be made on a case-by-case basis. Additional studies are needed to identify subgroups of patients with unprovoked VTE at highest risk for occult cancer. Copyright © 2017 Elsevier Ltd. All rights reserved.

Seroprevalence of Toxoplasma gondii in Iberian pig sows.

PubMed

Pablos-Tanarro, Alba; Ortega-Mora, Luis Miguel; Palomo, Antonio; Casasola, Francisco; Ferre, Ignacio

2018-05-01

The objective of the present study was to investigate the seroprevalence of Toxoplasma gondii infection in Iberian sows reared in extensive and intensive management conditions and to compare two serologic techniques used for diagnosis. In addition, some possible risk factors associated with the presence of serum antibodies to T. gondii were also studied. Serum samples were collected from 2492 Iberian sows on 14 pig farms. Three types of management systems were included, traditional extensive outdoor farms (five farms), intensive farms with outdoor access (n = 4), and conventional intensive indoor farms (n = 5). The presence of serum antibodies to T. gondii was evaluated by two commercially available tests: an indirect enzyme-linked immunosorbent assay (ELISA) and a direct agglutination test (DAT). Serum antibodies against T. gondii were detected in 237 sows (9.5%) by at least one of the techniques used. The mean seroprevalence of toxoplasmosis in Iberian sows was 5.8% by ELISA and 8.9% by DAT. An agreement kappa-value of 0.68 (95%, CI = 0.63-0.74) was found between both tests. The results from this study suggest that the prevalence of T. gondii antibodies among Iberian sows seems to be moderate-low. The presence of serum antibodies against T. gondii in Iberian sows was associated to an extensive management system and low-level facilities of the farm, sow number (> 1000 animals), presence of cats, absence of rodent control and bird-proof nets in windows, well-water source, feed sources and storage (from the same farm and not stored in silo), absence of fences, and low farm worker qualification.

75 FR 48728 - The Hydrostatic Testing Provision of the Portable Fire Extinguishers Standard; Extension of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-11

... Hydrostatic Testing Provision of the Portable Fire Extinguishers Standard; Extension of the Office of... the information collection requirements contained in the Hydrostatic Testing provision of the Portable... 48729

Development and Testing of Carbon-Carbon Nozzle Extensions for Upper Stage Liquid Rocket Engines

NASA Technical Reports Server (NTRS)

Valentine, Peter G.; Gradl, Paul R.; Greene, Sandra E.

2017-01-01

Carbon-carbon (C-C) composite nozzle extensions are of interest for use on a variety of launch vehicle upper stage engines and in-space propulsion systems. The C-C nozzle extension technology and test capabilities being developed are intended to support National Aeronautics and Space Administration (NASA) and Department of Defense (DOD) requirements, as well as those of the broader Commercial Space industry. For NASA, C-C nozzle extension technology development primarily supports the NASA Space Launch System (SLS) and NASA's Commercial Space partners. Marshall Space Flight Center (MSFC) efforts are aimed at both (a) further developing the technology and databases needed to enable the use of composite nozzle extensions on cryogenic upper stage engines, and (b) developing and demonstrating low-cost capabilities for testing and qualifying composite nozzle extensions. Recent, on-going, and potential future work supporting NASA, DOD, and Commercial Space needs will be discussed. Information to be presented will include (a) recent and on-going mechanical, thermal, and hot-fire testing, as well as (b) potential future efforts to further develop and qualify domestic C-C nozzle extension solutions for the various upper stage engines under development.

On the design of airfoils in which the transition of the boundary layer is delayed

NASA Technical Reports Server (NTRS)

Tani, Itiro

1952-01-01

A method is presented for designing suitable thickness distributions and mean camber lines for airfoils permitting extensive chordwise laminar flow. Wind tunnel and flight tests confirming the existence of laminar flow; possible maintenance of laminar flow by area suction; and the effects of wind tunnel turbulence and surface roughness on the promotion of premature boundary layer transition are discussed. In addition, estimates of profile drag and scale effect on maximum lift of the derived airfoils are made.

Facilitating the exploitation of ERTS imagery using snow enhancement techniques

NASA Technical Reports Server (NTRS)

Wobber, F. J. (Principal Investigator); Martin, K. R.; Sheffield, C.; Russell, O.; Amato, R. V.

1973-01-01

The author has identified the following significant results. EarthSat has established an effective mail-based method for obtaining timely ground truth (snow depth) information over an extensive area. The method is both efficient and inexpensive compared with the cost of a similarly scaled direct field checking effort. Additional geological information has been acquired which is not shown in geological maps in the area. Excellent quality snow-free ERTS-1 transparencies of the test areas have been received and are being analyzed.

Lorentz-symmetry test at Planck-scale suppression with nucleons in a spin-polarized 133Cs cold atom clock

NASA Astrophysics Data System (ADS)

Pihan-Le Bars, H.; Guerlin, C.; Lasseri, R.-D.; Ebran, J.-P.; Bailey, Q. G.; Bize, S.; Khan, E.; Wolf, P.

2017-04-01

We introduce an improved model that links the frequency shift of the 133Cs hyperfine Zeeman transitions |F =3 ,mF ⟩↔|F =4 ,mF ⟩ to the Lorentz-violating Standard Model extension (SME) coefficients of the proton and neutron. The new model uses Lorentz transformations developed to second order in boost and additionally takes the nuclear structure into account, beyond the simple Schmidt model used previously in Standard Model extension analyses, thereby providing access to both proton and neutron SME coefficients including the isotropic coefficient c˜T T. Using this new model in a second analysis of the data delivered by the FO2 dual Cs/Rb fountain at Paris Observatory and previously analyzed in [1], we improve by up to 13 orders of magnitude the present maximum sensitivities for laboratory tests [2] on the c˜Q, c˜T J, and c˜T T coefficients for the neutron and on the c˜Q coefficient for the proton, reaching respectively 10-20, 10-17, 10-13, and 10-15 GeV .

Extensions of D-optimal Minimal Designs for Symmetric Mixture Models

PubMed Central

Raghavarao, Damaraju; Chervoneva, Inna

2017-01-01

The purpose of mixture experiments is to explore the optimum blends of mixture components, which will provide desirable response characteristics in finished products. D-optimal minimal designs have been considered for a variety of mixture models, including Scheffé's linear, quadratic, and cubic models. Usually, these D-optimal designs are minimally supported since they have just as many design points as the number of parameters. Thus, they lack the degrees of freedom to perform the Lack of Fit tests. Also, the majority of the design points in D-optimal minimal designs are on the boundary: vertices, edges, or faces of the design simplex. In This Paper, Extensions Of The D-Optimal Minimal Designs Are Developed For A General Mixture Model To Allow Additional Interior Points In The Design Space To Enable Prediction Of The Entire Response Surface Also a new strategy for adding multiple interior points for symmetric mixture models is proposed. We compare the proposed designs with Cornell (1986) two ten-point designs for the Lack of Fit test by simulations. PMID:29081574

Wash Solution Bath Life Extension for the Space Shuttle Rocket Motor Aqueous Cleaning System

NASA Technical Reports Server (NTRS)

Saunders, Chad; Evans, Kurt; Sagers, Neil

1999-01-01

A spray-in-air aqueous cleaning system, which replaced 1,1,1 trichloroethane (TCA) vapor degreasing, is used for critical cleaning of Space Shuttle Redesigned Solid Rocket Motor (RSRM) metal parts. Small-scale testing demonstrated that the alkaline-based wash solution possesses adequate soil loading and cleaning properties. However, full-scale testing exhibited unexpected depletion of some primary components of the wash solution. Specifically, there was a significant decrease in the concentration of sodium metasilicate which forced change-out of the wash solution after eight days. Extension of wash solution bath life was necessary to ease the burden of frequent change-out on manufacturing. A laboratory study supports a depletion mechanism that is initiated by the hydrolysis of sodium tripolyphosphate (STPP) lowering the pH of the solution. The decrease in pH causes polymerization and subsequent precipitation of sodium metasilicate (SM). Further investigation showed that maintaining the pH was the key to preventing the precipitation of the sodium metasilicate. Implementation to the full scale operation demonstrated that periodic additions of potassium hydroxide (KOH) extended the useful bath life to more than four months.

LIVVkit: An extensible, python-based, land ice verification and validation toolkit for ice sheet models

NASA Astrophysics Data System (ADS)

Kennedy, Joseph H.; Bennett, Andrew R.; Evans, Katherine J.; Price, Stephen; Hoffman, Matthew; Lipscomb, William H.; Fyke, Jeremy; Vargo, Lauren; Boghozian, Adrianna; Norman, Matthew; Worley, Patrick H.

2017-06-01

To address the pressing need to better understand the behavior and complex interaction of ice sheets within the global Earth system, significant development of continental-scale, dynamical ice sheet models is underway. Concurrent to the development of the Community Ice Sheet Model (CISM), the corresponding verification and validation (V&V) process is being coordinated through a new, robust, Python-based extensible software package, the Land Ice Verification and Validation toolkit (LIVVkit). Incorporated into the typical ice sheet model development cycle, it provides robust and automated numerical verification, software verification, performance validation, and physical validation analyses on a variety of platforms, from personal laptops to the largest supercomputers. LIVVkit operates on sets of regression test and reference data sets, and provides comparisons for a suite of community prioritized tests, including configuration and parameter variations, bit-for-bit evaluation, and plots of model variables to indicate where differences occur. LIVVkit also provides an easily extensible framework to incorporate and analyze results of new intercomparison projects, new observation data, and new computing platforms. LIVVkit is designed for quick adaptation to additional ice sheet models via abstraction of model specific code, functions, and configurations into an ice sheet model description bundle outside the main LIVVkit structure. Ultimately, through shareable and accessible analysis output, LIVVkit is intended to help developers build confidence in their models and enhance the credibility of ice sheet models overall.

Effects of wood biochar addition on growth of cherry radish (Raphanus sativus L. var. radculus pers)

NASA Astrophysics Data System (ADS)

Ke, Huadan; Zhang, Qian; Liu, Guocheng

2018-03-01

Extensive cultivation and unreasonable management of the farmland result in severe soil degradation such as compaction, acidification, and salinization. Our results showed that the biochar amendment increased the cherry radish germination rate, while barely influenced the fresh biomass of shoot and root. Moreover, both 1.5% and 3% biochar addition showed no significant difference in the fruit shape index of cherry radish compared to the control treatment. These results suggested that the biochar application alone could not improve the cherry radish growth in this tested soil. Thus, application of biochar combined with fertilizer or composted with organic wastes should be taken into account for this soil.

In-orbit evaluation of the control system/structural mode interactions of the OSO-8 spacecraft

NASA Technical Reports Server (NTRS)

Slafer, L. I.

1979-01-01

The Orbiting Solar Observatory-8 experienced severe structural mode/control loop interaction problems during the spacecraft development. Extensive analytical studies, using the hybrid coordinate modeling approach, and comprehensive ground testing were carried out in order to achieve the system's precision pointing performance requirements. A recent series of flight tests were conducted with the spacecraft in which a wide bandwidth, high resolution telemetry system was utilized to evaluate the on-orbit flexible dynamics characteristics of the vehicle along with the control system performance. The paper describes the results of these tests, reviewing the basic design problem, analytical approach taken, ground test philosophy, and on-orbit testing. Data from the tests was used to determine the primary mode frequency, damping, and servo coupling dynamics for the on-orbit condition. Additionally, the test results have verified analytically predicted differences between the on-orbit and ground test environments, and have led to a validation of both the analytical modeling and servo design techniques used during the development of the control system.

David Florida Laboratory: Support for mobile satellite communications

NASA Technical Reports Server (NTRS)

Dumoulin, Jean-Guy; Mamen, Rolf

1995-01-01

The comprehensive integration and environmental (including RF) test facilities of the Canadian Space Agency's David Florida Laboratory (CSA)(DFL) were used extensively for the MSAT Program. Following a description of the facilities, the paper outlines their application to the qualification of the two MSAT satellites following an overview of the test plan. Particular emphasis is given to passive intermodulation measurement (PIM) demands, which for the MSAT satellites, contributed to the need to extend the anechoic chamber. The extended chamber was also used for an EMC test and SAR signature test of the RADARSAT satellite. The DFL's facilities are being used for additional aspects of mobile satellite communications. One shielded anechoic Extra High Frequency (EHF) chamber and associated test equipment are employed predominantly for measuring the performance of the IRIDIUM satellites' Engineering Model Gateway Moveable Antennas (EM)(GMA). Other chambers are used for testing aeronautical antennas on behalf of Inmarsat. Still others combine thermal and PIM testing. The paper concludes with a review of the test requirements of evolving satcom missions such as Inmarsat Aero-1.

Optimization of Ultrasonic Fabric Cleaning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hand, T.E.

The fundamental purpose of this project was to research and develop a process that would reduce the cost and improve the environmental efficiency of the present dry-cleaning industry. This second phase of research (see report KCP-94-1006 for information gathered during the first phase) was intended to allow the optimal integration of all factors of ultrasonic fabric cleaning. For this phase, Garment Care performed an extensive literature search and gathered data from other researchers worldwide. The Garment Care-AlliedSignal team developed the requirements for a prototype cleaning tank for studies and acquired that tank and the additional equipment required to use itmore » properly. Garment Care and AlliedSignal acquired the transducers and generators from Surftran Martin-Walter in Sterling Heights, Michigan. Amway's Kelly Haley developed the test protocol, supplied hundreds of test swatches, gathered the data on the swatches before and after the tests, assisted with the cleaning tests, and prepared the final analysis of the results. AlliedSignal personnel, in conjunction with Amway and Garment Care staff, performed all the tests. Additional planning is under way for future testing by outside research facilities. The final results indicated repeatable performance and good results for single layered fabric swatches. Swatches that were cleaned as a ''sandwich,'' that is, three or more layers.« less

A best practice fall prevention exercise program to improve balance, strength / power, and psychosocial health in older adults: study protocol for a randomized controlled trial

PubMed Central

2013-01-01

Background With increasing age neuromuscular deficits (e.g., sarcopenia) may result in impaired physical performance and an increased risk for falls. Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline. Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. Additionally, the time-related effects of detraining are tested. Methods/Design Healthy old people (n = 54) between the age of 65 to 80 years will participate in this trial. The testing protocol comprises tests for the assessment of static / dynamic steady-state balance (i.e., Sharpened Romberg Test, instrumented gait analysis), proactive balance (i.e., Functional Reach Test; Timed Up and Go Test), reactive balance (i.e., perturbation test during bipedal stance; Push and Release Test), strength (i.e., hand grip strength test; Chair Stand Test), and power (i.e., Stair Climb Power Test; countermovement jump). Further, body composition will be analysed using a bioelectrical impedance analysis system. In addition, questionnaires for the assessment of psychosocial (i.e., World Health Organisation Quality of Life Assessment-Bref), cognitive (i.e., Mini Mental State Examination), and fall risk determinants (i.e., Fall Efficacy Scale – International) will be included in the study protocol. Participants will be randomized into two intervention groups or the control / waiting group. After baseline measures, participants in the intervention groups will conduct a 12-week balance and strength / power exercise intervention 3 times per week, with each training session lasting 30 min. (actual training time). One intervention group will complete an extensive supervised training program, while the other intervention group will complete a short version ('3 times 3’) that is home-based and controlled by weekly phone calls. Post-tests will be conducted right after the intervention period. Additionally, detraining effects will be measured 12 weeks after program cessation. The control group / waiting group will not participate in any specific intervention during the experimental period, but will receive the extensive supervised program after the experimental period. Discussion It is expected that particularly the supervised combination of balance and strength / power training will improve performance in variables of balance, strength / power, body composition, cognitive function, psychosocial well-being, and falls self-efficacy of older adults. In addition, information regarding fall risk assessment, dose–response-relations, detraining effects, and supervision of training will be provided. Further, training-induced health-relevant changes, such as improved performance in activities of daily living, cognitive function, and quality of life, as well as a reduced risk for falls may help to lower costs in the health care system. Finally, practitioners, therapists, and instructors will be provided with a scientifically evaluated feasible, safe, and easy-to-administer exercise program for fall prevention. Trial registration ClinicalTrials.gov Identifier: NCT01906034 PMID:24106864

The Silicon Trypanosome: a test case of iterative model extension in systems biology

PubMed Central

Achcar, Fiona; Fadda, Abeer; Haanstra, Jurgen R.; Kerkhoven, Eduard J.; Kim, Dong-Hyun; Leroux, Alejandro E.; Papamarkou, Theodore; Rojas, Federico; Bakker, Barbara M.; Barrett, Michael P.; Clayton, Christine; Girolami, Mark; Luise Krauth-Siegel, R.; Matthews, Keith R.; Breitling, Rainer

2016-01-01

The African trypanosome, Trypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome (SilicoTryp) is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology. PMID:24797926

Selected winglet and mixed flow long duct nacelle development for DC-10 derivative aircraft

NASA Technical Reports Server (NTRS)

Taylor, A. B.

1980-01-01

The high speed cruise drag effects of the installation of winglets and a wing tip extension and a mixed flow long duct nacelle are investigated. The winglet program utilized a 4.7 percent semispan model in an eight foot transonic wind tunnel. Winglets provided approximately twice the cruise drag reduction of wing tip extensions for about the same increase in bending moment at the wing-fuselage juncture. The long duct nacelle interference drag program utilized the same model, without the winglets, in the 11 foot transonic wind tunnel. The long duct nacelle, installed in the same position as the current short duct nacelle and with the current production symmetric pylon, was a relatively low risk installation. A pylon with an addition small rearward fairing was also tested and showed some drag reduction potential over the current pylon.

Space platforms - A cost effective evolution of Spacelab operation

NASA Technical Reports Server (NTRS)

Stofan, A. J.

1981-01-01

The capabilities added to the Shuttle/Spacelab configuration by the addition of the Power Extension Package (PEP), the Power System (PS), and the Science and Applications Space Platforms (SASP) are reviewed with an emphasis on SASP. SASP are intended for placement in orbit by the Shuttle to test new instruments and systems, for clustering of instrumentation, and for servicing, refurbishment, repair, or augmentation by the Shuttle. The PEP permits extended stays in orbit (30 days), and the PS is an orbital solar array and energy storage system acting as a free flying spacecraft. The Shuttle can deliver payloads to the PS or attach to it for extension of the Spacelab operations. Applications of SASP for long term space-based biological experiments are outlined, and the fact that SASP do not increase the required Shuttle in-orbit time is stressed.

SlicerRT: radiation therapy research toolkit for 3D Slicer.

PubMed

Pinter, Csaba; Lasso, Andras; Wang, An; Jaffray, David; Fichtinger, Gabor

2012-10-01

Interest in adaptive radiation therapy research is constantly growing, but software tools available for researchers are mostly either expensive, closed proprietary applications, or free open-source packages with limited scope, extensibility, reliability, or user support. To address these limitations, we propose SlicerRT, a customizable, free, and open-source radiation therapy research toolkit. SlicerRT aspires to be an open-source toolkit for RT research, providing fast computations, convenient workflows for researchers, and a general image-guided therapy infrastructure to assist clinical translation of experimental therapeutic approaches. It is a medium into which RT researchers can integrate their methods and algorithms, and conduct comparative testing. SlicerRT was implemented as an extension for the widely used 3D Slicer medical image visualization and analysis application platform. SlicerRT provides functionality specifically designed for radiation therapy research, in addition to the powerful tools that 3D Slicer offers for visualization, registration, segmentation, and data management. The feature set of SlicerRT was defined through consensus discussions with a large pool of RT researchers, including both radiation oncologists and medical physicists. The development processes used were similar to those of 3D Slicer to ensure software quality. Standardized mechanisms of 3D Slicer were applied for documentation, distribution, and user support. The testing and validation environment was configured to automatically launch a regression test upon each software change and to perform comparison with ground truth results provided by other RT applications. Modules have been created for importing and loading DICOM-RT data, computing and displaying dose volume histograms, creating accumulated dose volumes, comparing dose volumes, and visualizing isodose lines and surfaces. The effectiveness of using 3D Slicer with the proposed SlicerRT extension for radiation therapy research was demonstrated on multiple use cases. A new open-source software toolkit has been developed for radiation therapy research. SlicerRT can import treatment plans from various sources into 3D Slicer for visualization, analysis, comparison, and processing. The provided algorithms are extensively tested and they are accessible through a convenient graphical user interface as well as a flexible application programming interface.

Printing Outside the Box: Additive Manufacturing Processes for Fabrication of Large Aerospace Structures

NASA Technical Reports Server (NTRS)

Babai, Majid; Peters, Warren

2015-01-01

To achieve NASA's mission of space exploration, innovative manufacturing processes are being applied to the fabrication of propulsion elements. Liquid rocket engines (LREs) are comprised of a thrust chamber and nozzle extension as illustrated in figure 1 for the J2X upper stage engine. Development of the J2X engine, designed for the Ares I launch vehicle, is currently being incorporated on the Space Launch System. A nozzle extension is attached to the combustion chamber to obtain the expansion ratio needed to increase specific impulse. If the nozzle extension could be printed as one piece using free-form additive manufacturing (AM) processes, rather than the current method of forming welded parts, a considerable time savings could be realized. Not only would this provide a more homogenous microstructure than a welded structure, but could also greatly shorten the overall fabrication time. The main objective of this study is to fabricate test specimens using a pulsed arc source and solid wire as shown in figure 2. The mechanical properties of these specimens will be compared with those fabricated using the powder bed, selective laser melting technology at NASA Marshall Space Flight Center. As printed components become larger, maintaining a constant temperature during the build process becomes critical. This predictive capability will require modeling of the moving heat source as illustrated in figure 3. Predictive understanding of the heat profile will allow a constant temperature to be maintained as a function of height from substrate while printing complex shapes. In addition, to avoid slumping, this will also allow better control of the microstructural development and hence the properties. Figure 4 shows a preliminary comparison of the mechanical properties obtained.

Eccentric Training and Static Stretching Improve Hamstring Flexibility of High School Males

PubMed Central

Bandy, William D.

2004-01-01

Objective: To determine if the flexibility of high-school-aged males would improve after a 6-week eccentric exercise program. In addition, the changes in hamstring flexibility that occurred after the eccentric program were compared with a 6-week program of static stretching and with a control group (no stretching). Design and Setting: We used a test-retest control group design in a laboratory setting. Subjects were assigned randomly to 1 of 3 groups: eccentric training, static stretching, or control. Subjects: A total of 69 subjects, with a mean age of 16.45 ± 0.96 years and with limited hamstring flexibility (defined as 20° loss of knee extension measured with the thigh held at 90° of hip flexion) were recruited for this study. Measurements: Hamstring flexibility was measured using the passive 90/90 test before and after the 6-week program. Results: Differences were significant for test and for the test-by-group interaction. Follow-up analysis indicated significant differences between the control group (gain = 1.67°) and both the eccentric-training (gain = 12.79°) and static-stretching (gain = 12.05°) groups. No difference was found between the eccentric and static-stretching groups. Conclusions: The gains achieved in range of motion of knee extension (indicating improvement in hamstring flexibility) with eccentric training were equal to those made by statically stretching the hamstring muscles. PMID:15496995

Eccentric Training and Static Stretching Improve Hamstring Flexibility of High School Males.

PubMed

Nelson, Russell T; Bandy, William D

2004-09-01

OBJECTIVE: To determine if the flexibility of high-school-aged males would improve after a 6-week eccentric exercise program. In addition, the changes in hamstring flexibility that occurred after the eccentric program were compared with a 6-week program of static stretching and with a control group (no stretching). DESIGN AND SETTING: We used a test-retest control group design in a laboratory setting. Subjects were assigned randomly to 1 of 3 groups: eccentric training, static stretching, or control. SUBJECTS: A total of 69 subjects, with a mean age of 16.45 +/- 0.96 years and with limited hamstring flexibility (defined as 20 degrees loss of knee extension measured with the thigh held at 90 degrees of hip flexion) were recruited for this study. MEASUREMENTS: Hamstring flexibility was measured using the passive 90/90 test before and after the 6-week program. RESULTS: Differences were significant for test and for the test-by-group interaction. Follow-up analysis indicated significant differences between the control group (gain = 1.67 degrees ) and both the eccentric-training (gain = 12.79 degrees ) and static-stretching (gain = 12.05 degrees ) groups. No difference was found between the eccentric and static-stretching groups. CONCLUSIONS: The gains achieved in range of motion of knee extension (indicating improvement in hamstring flexibility) with eccentric training were equal to those made by statically stretching the hamstring muscles.

Design of a composite wing extension for a general aviation aircraft

NASA Technical Reports Server (NTRS)

Adney, P. S.; Horn, W. J.

1984-01-01

A composite wing extension was designed for a typical general aviation aircraft to improve lift curve slope, dihedral effect, and lift to drag ratio. Advanced composite materials were used in the design to evaluate their use as primary structural components in general aviation aircraft. Extensive wind tunnel tests were used to evaluate six extension shapes. The extension shape chosen as the best choice was 28 inches long with a total area of 17 square feet. Subsequent flight tests showed the wing extension's predicted aerodynamic improvements to be correct. The structural design of the wing extension consisted of a hybrid laminate carbon core with outer layers of Kevlar - layed up over a foam interior which acted as an internal support. The laminate skin of the wing extension was designed from strength requirements, and the foam core was included to prevent buckling. A joint lap was recommended to attach the wing extension to the main wing structure.

Association of lower extremity range of motion and muscle strength with physical performance of community-dwelling older women.

PubMed

Jung, Hungu; Yamasaki, Masahiro

2016-12-08

Reduced lower extremity range of motion (ROM) and muscle strength are related to functional disability in older adults who cannot perform one or more activities of daily living (ADL) independently. The purpose of this study was to determine which factors of seven lower extremity ROMs and two muscle strengths play dominant roles in the physical performance of community-dwelling older women. Ninety-five community-dwelling older women (mean age ± SD, 70.7 ± 4.7 years; age range, 65-83 years) were enrolled in this study. Seven lower extremity ROMs (hip flexion, hip extension, knee flexion, internal and external hip rotation, ankle dorsiflexion, and ankle plantar flexion) and two muscle strengths (knee extension and flexion) were measured. Physical performance tests, including functional reach test (FRT), 5 m gait test, four square step test (FSST), timed up and go test (TUGT), and five times sit-to-stand test (FTSST) were performed. Stepwise regression models for each of the physical performance tests revealed that hip extension ROM and knee flexion strength were important explanatory variables for FRT, FSST, and FTSST. Furthermore, ankle plantar flexion ROM and knee extension strength were significant explanatory variables for the 5 m gait test and TUGT. However, ankle dorsiflexion ROM was a significant explanatory variable for FRT alone. The amount of variance on stepwise multiple regression for the five physical performance tests ranged from 25 (FSST) to 47% (TUGT). Hip extension, ankle dorsiflexion, and ankle plantar flexion ROMs, as well as knee extension and flexion strengths may play primary roles in the physical performance of community-dwelling older women. Further studies should assess whether specific intervention programs targeting older women may achieve improvements in lower extremity ROM and muscle strength, and thereby play an important role in the prevention of dependence on daily activities and loss of physical function, particularly focusing on hip extension, ankle dorsiflexion, and ankle plantar flexion ROMs as well as knee extension and flexion strength.

Recovery strategies for tackling the impact of phenolic compounds in a UASB reactor treating coal gasification wastewater.

PubMed

Wang, Wei; Han, Hongjun

2012-01-01

The impact of phenolic compounds (around 3.2 g/L) resulted in a completely failed performance in a mesophilic UASB reactor treating coal gasification wastewater. The recovery strategies, including extension of HRT, dilution, oxygen-limited aeration, and addition of powdered activated carbon were evaluated in batch tests, in order to obtain the most appropriate way for the quick recovery of the failed reactor performance. Results indicated that addition of powdered activated carbon and oxygen-limited aeration were the best recovery strategies in the batch tests. In the UASB reactor, addition of powdered activated carbon of 1 g/L shortened the recovery time from 25 to 9 days and oxygen-limited aeration of 0-0.5 mgO2/L reduced the recovery time to 17 days. Reduction of bioavailable concentration of phenolic compounds and recovery of sludge activity were the decisive factors for the recovery strategies to tackle the impact of phenolic compounds in anaerobic treatment of coal gasification wastewater. Copyright © 2011 Elsevier Ltd. All rights reserved.

Evaluation of a teflon based ultraviolet light system on the disinfection of water in a textile air washer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, J.E.; Whisnant, R.B.

The report provides an in-depth evaluation of an ultraviolet (UV) disinfection unit as applied to the treatment of cooling water in a textile air washer system. The UV unit tests used a teflon tube to transport the aquatic phase. The unit reduced microbial populations and maintained an average level of 10,000 Colony formed unites/mL for the 6-month testing period, without the addition of biocides. No cleaning or other maintenance was required of the wetted surfaces during the testing period. Slime deposits observed on walls of the air washer during chemical treatment were also eliminated. The UV unit can be utilizedmore » on both cooling towers and air washers without extensive installation.« less

Flat-plate solar array project. Volume 6: Engineering sciences and reliability

NASA Technical Reports Server (NTRS)

Ross, R. G., Jr.; Smokler, M. I.

1986-01-01

The Flat-Plate Solar Array (FSA) Project activities directed at developing the engineering technology base required to achieve modules that meet the functional, safety, and reliability requirements of large scale terrestrial photovoltaic systems applications are reported. These activities included: (1) development of functional, safety, and reliability requirements for such applications; (2) development of the engineering analytical approaches, test techniques, and design solutions required to meet the requirements; (3) synthesis and procurement of candidate designs for test and evaluation; and (4) performance of extensive testing, evaluation, and failure analysis of define design shortfalls and, thus, areas requiring additional research and development. A summary of the approach and technical outcome of these activities are provided along with a complete bibliography of the published documentation covering the detailed accomplishments and technologies developed.

Learning moment-based fast local binary descriptor

NASA Astrophysics Data System (ADS)

Bellarbi, Abdelkader; Zenati, Nadia; Otmane, Samir; Belghit, Hayet

2017-03-01

Recently, binary descriptors have attracted significant attention due to their speed and low memory consumption; however, using intensity differences to calculate the binary descriptive vector is not efficient enough. We propose an approach to binary description called POLAR_MOBIL, in which we perform binary tests between geometrical and statistical information using moments in the patch instead of the classical intensity binary test. In addition, we introduce a learning technique used to select an optimized set of binary tests with low correlation and high variance. This approach offers high distinctiveness against affine transformations and appearance changes. An extensive evaluation on well-known benchmark datasets reveals the robustness and the effectiveness of the proposed descriptor, as well as its good performance in terms of low computation complexity when compared with state-of-the-art real-time local descriptors.

Cladonia lichens on extensive green roofs: evapotranspiration, substrate temperature, and albedo.

PubMed

Heim, Amy; Lundholm, Jeremy

2013-01-01

Green roofs are constructed ecosystems that provide ecosystem services in urban environments. Shallow substrate green roofs subject the vegetation layer to desiccation and other environmental extremes, so researchers have evaluated a variety of stress-tolerant vegetation types for green roof applications. Lichens can be found in most terrestrial habitats.  They are able to survive extremely harsh conditions, including frequent cycles of desiccation and rehydration, nutrient-poor soil, fluctuating temperatures, and high UV intensities. Extensive green roofs (substrate depth <20cm) exhibit these harsh conditions, making lichens possible candidates for incorporation into the vegetation layer on extensive green roofs.  In a modular green roof system, we tested the effect of Cladonia lichens on substrate temperature, water loss, and albedo compared to a substrate-only control. Overall, the Cladonia modules had significantly cooler substrate temperatures during the summer and significantly warmer temperatures during the fall.  Additionally, the Cladonia modules lost significantly less water than the substrate-only control. This implies that they may be able to benefit neighboring vascular plant species by reducing water loss and maintaining favorable substrate temperatures.

Additional extensions to the NASCAP computer code, volume 2

NASA Technical Reports Server (NTRS)

Stannard, P. R.; Katz, I.; Mandell, M. J.

1982-01-01

Particular attention is given to comparison of the actural response of the SCATHA (Spacecraft Charging AT High Altitudes) P78-2 satellite with theoretical (NASCAP) predictions. Extensive comparisons for a variety of environmental conditions confirm the validity of the NASCAP model. A summary of the capabilities and range of validity of NASCAP is presented, with extensive reference to previously published applications. It is shown that NASCAP is capable of providing quantitatively accurate results when the object and environment are adequately represented and fall within the range of conditions for which NASCAP was intended. Three dimensional electric field affects play an important role in determining the potential of dielectric surfaces and electrically isolated conducting surfaces, particularly in the presence of artificially imposed high voltages. A theory for such phenomena is presented and applied to the active control experiments carried out in SCATHA, as well as other space and laboratory experiments. Finally, some preliminary work toward modeling large spacecraft in polar Earth orbit is presented. An initial physical model is presented including charge emission. A simple code based upon the model is described along with code test results.

Intelligent fault management for the Space Station active thermal control system

NASA Technical Reports Server (NTRS)

Hill, Tim; Faltisco, Robert M.

1992-01-01

The Thermal Advanced Automation Project (TAAP) approach and architecture is described for automating the Space Station Freedom (SSF) Active Thermal Control System (ATCS). The baseline functionally and advanced automation techniques for Fault Detection, Isolation, and Recovery (FDIR) will be compared and contrasted. Advanced automation techniques such as rule-based systems and model-based reasoning should be utilized to efficiently control, monitor, and diagnose this extremely complex physical system. TAAP is developing advanced FDIR software for use on the SSF thermal control system. The goal of TAAP is to join Knowledge-Based System (KBS) technology, using a combination of rules and model-based reasoning, with conventional monitoring and control software in order to maximize autonomy of the ATCS. TAAP's predecessor was NASA's Thermal Expert System (TEXSYS) project which was the first large real-time expert system to use both extensive rules and model-based reasoning to control and perform FDIR on a large, complex physical system. TEXSYS showed that a method is needed for safely and inexpensively testing all possible faults of the ATCS, particularly those potentially damaging to the hardware, in order to develop a fully capable FDIR system. TAAP therefore includes the development of a high-fidelity simulation of the thermal control system. The simulation provides realistic, dynamic ATCS behavior and fault insertion capability for software testing without hardware related risks or expense. In addition, thermal engineers will gain greater confidence in the KBS FDIR software than was possible prior to this kind of simulation testing. The TAAP KBS will initially be a ground-based extension of the baseline ATCS monitoring and control software and could be migrated on-board as additional computation resources are made available.

TomoPhantom, a software package to generate 2D-4D analytical phantoms for CT image reconstruction algorithm benchmarks

NASA Astrophysics Data System (ADS)

Kazantsev, Daniil; Pickalov, Valery; Nagella, Srikanth; Pasca, Edoardo; Withers, Philip J.

2018-01-01

In the field of computerized tomographic imaging, many novel reconstruction techniques are routinely tested using simplistic numerical phantoms, e.g. the well-known Shepp-Logan phantom. These phantoms cannot sufficiently cover the broad spectrum of applications in CT imaging where, for instance, smooth or piecewise-smooth 3D objects are common. TomoPhantom provides quick access to an external library of modular analytical 2D/3D phantoms with temporal extensions. In TomoPhantom, quite complex phantoms can be built using additive combinations of geometrical objects, such as, Gaussians, parabolas, cones, ellipses, rectangles and volumetric extensions of them. Newly designed phantoms are better suited for benchmarking and testing of different image processing techniques. Specifically, tomographic reconstruction algorithms which employ 2D and 3D scanning geometries, can be rigorously analyzed using the software. TomoPhantom also provides a capability of obtaining analytical tomographic projections which further extends the applicability of software towards more realistic, free from the "inverse crime" testing. All core modules of the package are written in the C-OpenMP language and wrappers for Python and MATLAB are provided to enable easy access. Due to C-based multi-threaded implementation, volumetric phantoms of high spatial resolution can be obtained with computational efficiency.

A powerful and flexible approach to the analysis of RNA sequence count data.

PubMed

Zhou, Yi-Hui; Xia, Kai; Wright, Fred A

2011-10-01

A number of penalization and shrinkage approaches have been proposed for the analysis of microarray gene expression data. Similar techniques are now routinely applied to RNA sequence transcriptional count data, although the value of such shrinkage has not been conclusively established. If penalization is desired, the explicit modeling of mean-variance relationships provides a flexible testing regimen that 'borrows' information across genes, while easily incorporating design effects and additional covariates. We describe BBSeq, which incorporates two approaches: (i) a simple beta-binomial generalized linear model, which has not been extensively tested for RNA-Seq data and (ii) an extension of an expression mean-variance modeling approach to RNA-Seq data, involving modeling of the overdispersion as a function of the mean. Our approaches are flexible, allowing for general handling of discrete experimental factors and continuous covariates. We report comparisons with other alternate methods to handle RNA-Seq data. Although penalized methods have advantages for very small sample sizes, the beta-binomial generalized linear model, combined with simple outlier detection and testing approaches, appears to have favorable characteristics in power and flexibility. An R package containing examples and sample datasets is available at http://www.bios.unc.edu/research/genomic_software/BBSeq yzhou@bios.unc.edu; fwright@bios.unc.edu Supplementary data are available at Bioinformatics online.

19 CFR 201.14 - Computation of time, additional hearings, postponements, continuances, and extensions of time.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Computation of time, additional hearings, postponements, continuances, and extensions of time. 201.14 Section 201.14 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Initiation and Conduct of Investigations...

19 CFR 201.14 - Computation of time, additional hearings, postponements, continuances, and extensions of time.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Computation of time, additional hearings, postponements, continuances, and extensions of time. 201.14 Section 201.14 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Initiation and Conduct of Investigations...

19 CFR 210.6 - Computation of time, additional hearings, postponements, continuances, and extensions of time.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Computation of time, additional hearings, postponements, continuances, and extensions of time. 210.6 Section 210.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT...

SSME structural dynamic model development, phase 2

NASA Technical Reports Server (NTRS)

Foley, M. J.; Wilson, V. L.

1985-01-01

A set of test correlated mathematical models of the SSME High Pressure Oxygen Turbopump (HPOTP) housing and rotor assembly was produced. New analysis methods within the EISI/EAL and SPAR systems were investigated and runstreams for future use were developed. The LOX pump models have undergone extensive modification since the first phase of this effort was completed. The rotor assembly from the original model was abandoned and a new, more detailed model constructed. A description of the new rotor math model is presented. Also, the pump housing model was continually modified as additional test data have become available. This model is documented along with measured test results. Many of the more advanced features of the EAL/SPAR finite element analysis system were exercised. These included the cyclic symmetry option, the macro-element procedures, and the fluid analysis capability. In addition, a new tool was developed that allows an automated analysis of a disjoint structure in terms of its component modes. A complete description of the implementation of the Craig-Bampton method is given along with two worked examples.

An investigation of the effects of pitch-roll (de)coupling on helicopter handling qualities

NASA Technical Reports Server (NTRS)

Blanken, C. L.; Pausder, H. J.; Ockier, C. J.

1995-01-01

An extensive investigation of the effects of pitch-roll coupling on helicopter handling qualities was performed by the U.S. Army and Deutsche Forschungsanstalt fur Luft- und Raumfahrt (DLR), using a NASA ground-based and a DLR in-flight simulator. Over 90 different coupling configurations were evaluated using a high gain roll-axis tracking task. The results show that although the current ADS-33C coupling criterion discriminates against those types of coupling typical of conventionally controlled helicopters, it is not always suited for the prediction of handling qualities of helicopters with modern control systems. Based on the observation that high frequency inputs during tracking are used to alleviate coupling, a frequency domain pitch-roll coupling criterion that uses the average coupling ratio between the bandwidth and neutral stability frequency is formulated. This criterion provides a more comprehensive coverage with respect to the different types of coupling, shows excellent consistency, and has the additional benefit that compliance testing data are obtained from the bandwidth/phase delay tests, so that no additional flight testing is needed.

Succinic acid in levels produced by yeast (Saccharomyces cerevisiae) during fermentation strongly impacts wheat bread dough properties.

PubMed

Jayaram, Vinay B; Cuyvers, Sven; Verstrepen, Kevin J; Delcour, Jan A; Courtin, Christophe M

2014-05-15

Succinic acid (SA) was recently shown to be the major pH determining metabolite produced by yeast during straight-dough fermentation (Jayaram et al., 2013), reaching levels as high as 1.6 mmol/100 g of flour. Here, the impact of such levels of SA (0.8, 1.6 and 2.4 mmol/100 g flour) on yeastless dough properties was investigated. SA decreased the development time and stability of dough significantly. Uniaxial extension tests showed a consistent decrease in dough extensibility upon increasing SA addition. Upon biaxial extension in the presence of 2.4 mmol SA/100 g flour, a dough extensibility decrease of 47-65% and a dough strength increase of 25-40% were seen. While the SA solvent retention capacity of flour increased with increasing SA concentration in the solvent, gluten agglomeration decreased with gluten yield reductions of over 50%. The results suggest that SA leads to swelling and unfolding of gluten proteins, thereby increasing their interaction potential and dough strength, but simultaneously increasing intermolecular electrostatic repulsive forces. These phenomena lead to the reported changes in dough properties. Together, our results establish SA as an important yeast metabolite for dough rheology. Copyright © 2013 Elsevier Ltd. All rights reserved.

Modeling along-axis variations in fault architecture in the Main Ethiopian Rift: implications for Nubia-Somalia kinematics

NASA Astrophysics Data System (ADS)

Erbello, Asfaw; Corti, Giacomo; Sani, Federico; Kidane, Tesfaye

2016-04-01

The Main Ethiopian Rift (MER), at the northern termination of the East African Rift, is an ideal locale where to get insights into the long-term motion between Nubia and Somalia. The rift is indeed one of the few places along the plate boundary where the deformation is narrow: its evolution is thus strictly related to the kinematics of the two major plates, whereas south of the Turkana depression a two-plate model for the EARS is too simplistic as extension occurs both along the Western and Eastern branches and different microplates are present between the two major plates. Despite its importance, the kinematics responsible for development and evolution of the MER is still a matter of debate: indeed, whereas the Quaternary-present kinematics of rifting is rather well constrained, the plate kinematics driving the initial, Mio-Pliocene stages of extension is still not clear, and different hypothesis have been put forward, including: polyphase rifting, with a change in direction of extension from NW-SE extension to E-W extension; constant Miocene-recent NW-SE extension; constant Miocene-recent NE-SW extension; constant, post-11 Ma extension consistent with the GPS-derived kinematics (i.e., roughly E-W to ESE-WNW). To shed additional light on this controversy and to test these different hypothesis, in this contribution we use new crustal-scale analogue models to analyze the along-strike variations in fault architecture in the MER and their relations with the rift trend, plate motion and the resulting Miocene-recent kinematics of rifting. The extension direction is indeed one of the most important parameters controlling the architecture of continental rifts and the relative abundance and orientation of different fault sets that develop during oblique rifting is typically a function of the angle between the extension direction and the orthogonal to the rift trend (i.e., the obliquity angle). Since the trend of the MER varies along strike, and consequently it is characterized by a variable obliquity angle (i.e., kinematics) along its length, the analysis of fault architecture and its variations are able to provide significant insights into the plate kinematics responsible for rift development and evolution. Our models thus reproduce the overall geometry of the ~600km-long MER with its along-strike variation in orientation to test the above-described hypothesis of rift evolution. Analysis of model results in terms of statistics of fault length and orientation, and deformation architecture and its comparison with the MER suggests that rift has likely developed under a constant, post-11 Ma extension oriented roughly E-W (N97.5°E), consistent with recent plate kinematics models.

Vulnerability-specific stress generation: An examination of negative cognitive and interpersonal styles

PubMed Central

Liu, Richard T.; Alloy, Lauren B.; Mastin, Becky M.; Choi, Jimmy Y.; Boland, Elaine M.; Jenkins, Abby L.

2014-01-01

Although there is substantial evidence documenting the stress generation effect in depression (i.e., the tendency for depression-prone individuals to experience higher rates of life stress to which they contribute), additional research is required to advance current understanding of the specific types of dependent stress (i.e., events influenced by characteristics and attendant behaviors of the individual) relevant to this effect. The present study tested an extension of the stress generation hypothesis, in which the content of dependent stress that is produced by depression-prone individuals is contingent upon, and matches, the nature of their particular vulnerabilities. This extension was tested within the context of two cognitive models (i.e., hopelessness theory [Abramson, Metalsky, & Alloy, 1989] and Cole’s [1990, 1991] competency-based model) and two interpersonal models (i.e., Swann’s [1987] self-verification theory and Coyne’s [1976] interpersonal theory) of depression. Overall, support was obtained for vulnerability-specific stress generation. Specifically, in analyses across vulnerability domains, evidence of stress-generation specificity was found for all domain-specific cognitive vulnerabilities except self-perceived social competence. The within-domain analyses for cognitive vulnerabilities produced more mixed results, but were largely supportive. Additionally, excessive reassurance-seeking was specifically predictive of dependent stress in the social domain, and moderated, but did not mediate, the relation between negative inferential styles overall and in the interpersonal domain and their corresponding generated stress. Finally, no evidence was found for a stress generation effect with negative feedback-seeking. PMID:24679143

A linkage disequilibrium perspective on the genetic mosaic of speciation in two hybridizing Mediterranean white oaks

PubMed Central

Goicoechea, P G; Herrán, A; Durand, J; Bodénès, C; Plomion, C; Kremer, A

2015-01-01

We analyzed the genetic mosaic of speciation in two hybridizing Mediterranean white oaks from the Iberian Peninsula (Quercus faginea Lamb. and Quercus pyrenaica Willd.). The two species show ecological divergence in flowering phenology, leaf morphology and composition, and in their basic or acidic soil preferences. Ninety expressed sequence tag-simple sequence repeats (EST-SSRs) and eight nuclear SSRs were genotyped in 96 trees from each species. Genotyping was designed in two steps. First, we used 69 markers evenly distributed over the 12 linkage groups (LGs) of the oak linkage map to confirm the species genetic identity of the sampled genotypes, and searched for differentiation outliers. Then, we genotyped 29 additional markers from the chromosome bins containing the outliers and repeated the multilocus scans. We found one or two additional outliers within four saturated bins, thus confirming that outliers are organized into clusters. Linkage disequilibrium (LD) was extensive; even for loosely linked and for independent markers. Consequently, score tests for association between two-marker haplotypes and the ‘species trait' showed a broad genomic divergence, although substantial variation across the genome and within LGs was also observed. We discuss the influence of several confounding effects on neutrality tests and review the evolutionary processes leading to extensive LD. Finally, we examine how LD analyses within regions that contain outlier clusters and quantitative trait loci can help to identify regions of divergence and/or genomic hitchhiking in the light of predictions from ecological speciation theory. PMID:25515016

The Relationship Between the Lower-Body Muscular Profile and Swimming Start Performance

PubMed Central

García-Ramos, Amador; Tomazin, Katja; Strojnik, Vojko; de la Fuente, Blanca; Argüelles-Cienfuegos, Javier; Strumbelj, Boro; Štirn, Igor

2016-01-01

Abstract This study aimed to examine the correlation of different dry land strength and power tests with swimming start performance. Twenty international level female swimmers (age 15.3 ± 1.6 years, FINA point score 709.6 ± 71.1) performed the track freestyle start. Additionally, dry land tests were conducted: a) squat (SJ) and countermovement jumps (CMJ), b) squat jumps with additional resistance equivalent to 25, 50, 75 and 100% of swimmers’ body weight [BW]), and c) leg extension and leg flexion maximal voluntary isometric contractions. Correlations between dry land tests and start times at 5, 10 and 15 m were quantified through Pearson’s linear correlation coefficients (r). The peak bar velocity reached during the jumps with additional resistance was the variable most correlated to swimming start performance (r = -0.57 to -0.66 at 25%BW; r = -0.57 to -0.72 at 50%BW; r = -0.59 to -0.68 at 75%BW; r = -0.50 to - 0.64 at 100%BW). A few significant correlations between the parameters of the SJ and the CMJ with times of 5 and 10 m were found, and none with the isometric variables. The peak velocity reached during jumps with external loads relative to BW was found a good indicator of swimming start performance. PMID:28149353

Bringing the DuPont Profitability Model to Extension

ERIC Educational Resources Information Center

Roucan-Kane, Maud; Wolfskill, L. A.; Boehlje, Michael D.; Gray, Allan W.

2013-01-01

This article discusses a financial training program used by Deere and Company for almost 10 years. The objective is to describe the program and to discuss a pre-test/post-test methodology to test the effectiveness of a program for possible duplication by Extension. Results show that participants significantly improved from the pre-test to the…

Airframe noise prediction evaluation

NASA Technical Reports Server (NTRS)

Yamamoto, Kingo J.; Donelson, Michael J.; Huang, Shumei C.; Joshi, Mahendra C.

1995-01-01

The objective of this study is to evaluate the accuracy and adequacy of current airframe noise prediction methods using available airframe noise measurements from tests of a narrow body transport (DC-9) and a wide body transport (DC-10) in addition to scale model test data. General features of the airframe noise from these aircraft and models are outlined. The results of the assessment of two airframe prediction methods, Fink's and Munson's methods, against flight test data of these aircraft and scale model wind tunnel test data are presented. These methods were extensively evaluated against measured data from several configurations including clean, slat deployed, landing gear-deployed, flap deployed, and landing configurations of both DC-9 and DC-10. They were also assessed against a limited number of configurations of scale models. The evaluation was conducted in terms of overall sound pressure level (OASPL), tone corrected perceived noise level (PNLT), and one-third-octave band sound pressure level (SPL).

Verification study of an emerging fire suppression system

DOE PAGES

Cournoyer, Michael E.; Waked, R. Ryan; Granzow, Howard N.; ...

2016-01-01

Self-contained fire extinguishers are a robust, reliable and minimally invasive means of fire suppression for gloveboxes. Moreover, plutonium gloveboxes present harsh environmental conditions for polymer materials; these include radiation damage and chemical exposure, both of which tend to degrade the lifetime of engineered polymer components. Several studies have been conducted to determine the robustness of selfcontained fire extinguishers in plutonium gloveboxes in a nuclear facility, verification tests must be performed. These tests include activation and mass loss calorimeter tests. In addition, compatibility issues with chemical components of the self-contained fire extinguishers need to be addressed. Our study presents activation andmore » mass loss calorimeter test results. After extensive studies, no critical areas of concern have been identified for the plutonium glovebox application of Fire Foe™, except for glovebox operations that use large quantities of bulk plutonium or uranium metal such as metal casting and pyro-chemistry operations.« less

Effect of Coversheet Materials on the Acoustic Performance of Melamine Foam

NASA Technical Reports Server (NTRS)

McNelis, Anne M.; Hughes, William O.

2015-01-01

Melamine foam is a highly absorptive material that is often used inside the payload fairing walls of a launch vehicle. This foam reduces the acoustic excitation environment that the spacecraft experiences during launch. Often, the melamine foam is enclosed by thin coversheet materials for contamination protection, thermal protection, and electrostatic discharge control. Previous limited acoustic testing by NASA Glenn Research Center has shown that the presence of a coversheet material on the melamine foam can have a significant impact on the absorption coefficient and the transmission loss. As a result of this preliminary finding a more extensive acoustic test program using several different coversheet materials on melamine foam was performed. Those test results are summarized in this paper. Additionally, a method is provided to use the acoustic absorption and transmission loss data obtained from panel level testing to predict their combined effect for the noise reduction of a launch vehicle payload fairing.

Verification study of an emerging fire suppression system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cournoyer, Michael E.; Waked, R. Ryan; Granzow, Howard N.

Self-contained fire extinguishers are a robust, reliable and minimally invasive means of fire suppression for gloveboxes. Moreover, plutonium gloveboxes present harsh environmental conditions for polymer materials; these include radiation damage and chemical exposure, both of which tend to degrade the lifetime of engineered polymer components. Several studies have been conducted to determine the robustness of selfcontained fire extinguishers in plutonium gloveboxes in a nuclear facility, verification tests must be performed. These tests include activation and mass loss calorimeter tests. In addition, compatibility issues with chemical components of the self-contained fire extinguishers need to be addressed. Our study presents activation andmore » mass loss calorimeter test results. After extensive studies, no critical areas of concern have been identified for the plutonium glovebox application of Fire Foe™, except for glovebox operations that use large quantities of bulk plutonium or uranium metal such as metal casting and pyro-chemistry operations.« less

Development and mechanical properties of construction materials from lunar simulants

NASA Technical Reports Server (NTRS)

Desai, Chandra S.

1990-01-01

The development of construction materials such as concrete from lunar soils without the use of water requires a different methodology than that used for conventional terrestrial concrete. Currently, this research involves two aspects: (1) liquefaction of lunar simulants with various additives in a furnace so as to produce a construction material like an intermediate ceramic; and (2) cyclic loading of simulant with different initial vacuums and densities with respect to the theoretical maximum densities (TMD). In both cases, bending, triaxial compression, extension, and hydrostatic tests will be performed to define the stress-strain strength response of the resulting materials. In the case of the intermediate ceramic, bending and available multiaxial test devices will be used, while for the compacted case, tests will be performed directly in the new device. The tests will be performed by simulating in situ confining conditions. A preliminary review of high-purity metal is also conducted.

On-orbit evaluation of the control system/structural mode interactions on OSO-8

NASA Technical Reports Server (NTRS)

Slafer, L. I.

1980-01-01

The Orbiting Solar Observatory-8 experienced severe structural mode/control loop interaction problems during the spacecraft development. Extensive analytical studies, using the hybrid coordinate modeling approach, and comprehensive ground testing were carried out in order to achieve the system's precision pointing performance requirements. A recent series of flight tests were conducted with the spacecraft in which a wide bandwidth, high resolution telemetry system was utilized to evaluate the on-orbit flexible dynamics characteristics of the vehicle along with the control system performance. This paper describes the results of these tests, reviewing the basic design problem, analytical approach taken, ground test philosophy, and on-orbit testing. Data from the tests was used to determine the primary mode frequency, damping, and servo coupling dynamics for the on-orbit condition. Additionally, the test results have verified analytically predicted differences between the on-orbit and ground test environments. The test results have led to a validation of both the analytical modeling and servo design techniques used during the development of the control system, and also verified the approach taken to vehicle and servo ground testing.

Rare-Variant Association Analysis: Study Designs and Statistical Tests

PubMed Central

Lee, Seunggeung; Abecasis, Gonçalo R.; Boehnke, Michael; Lin, Xihong

2014-01-01

Despite the extensive discovery of trait- and disease-associated common variants, much of the genetic contribution to complex traits remains unexplained. Rare variants can explain additional disease risk or trait variability. An increasing number of studies are underway to identify trait- and disease-associated rare variants. In this review, we provide an overview of statistical issues in rare-variant association studies with a focus on study designs and statistical tests. We present the design and analysis pipeline of rare-variant studies and review cost-effective sequencing designs and genotyping platforms. We compare various gene- or region-based association tests, including burden tests, variance-component tests, and combined omnibus tests, in terms of their assumptions and performance. Also discussed are the related topics of meta-analysis, population-stratification adjustment, genotype imputation, follow-up studies, and heritability due to rare variants. We provide guidelines for analysis and discuss some of the challenges inherent in these studies and future research directions. PMID:24995866

Accelerated Testing Methodology in Constant Stress-Rate Testing for Advanced Structural Ceramics: A Preloading Technique

NASA Technical Reports Server (NTRS)

Choi, Sung R.; Gyekenyesi, John P.; Huebert, Dean; Bartlett, Allen; Choi, Han-Ho

2001-01-01

Preloading technique was used as a means of an accelerated testing methodology in constant stress-rate ('dynamic fatigue') testing for two different brittle materials. The theory developed previously for fatigue strength as a function of preload was further verified through extensive constant stress-rate testing for glass-ceramic and CRT glass in room temperature distilled water. The preloading technique was also used in this study to identify the prevailing failure mechanisms at elevated temperatures, particularly at lower test rate in which a series of mechanisms would be associated simultaneously with material failure, resulting in significant strength increase or decrease. Two different advanced ceramics including SiC whisker-reinforced composite silicon nitride and 96 wt% alumina were used at elevated temperatures. It was found that the preloading technique can be used as an additional tool to pinpoint the dominant failure mechanism that is associated with such a phenomenon of considerable strength increase or decrease.

Accelerated Testing Methodology in Constant Stress-Rate Testing for Advanced Structural Ceramics: A Preloading Technique

NASA Technical Reports Server (NTRS)

Choi, Sung R.; Gyekenyesi, John P.; Huebert, Dean; Bartlett, Allen; Choi, Han-Ho

2001-01-01

Preloading technique was used as a means of an accelerated testing methodology in constant stress-rate (dynamic fatigue) testing for two different brittle materials. The theory developed previously for fatigue strength as a function of preload was further verified through extensive constant stress-rate testing for glass-ceramic and CRT glass in room temperature distilled water. The preloading technique was also used in this study to identify the prevailing failure mechanisms at elevated temperatures, particularly at lower test rates in which a series of mechanisms would be associated simultaneously with material failure, resulting in significant strength increase or decrease. Two different advanced ceramics including SiC whisker-reinforced composite silicon nitride and 96 wt% alumina were used at elevated temperatures. It was found that the preloading technique can be used as an additional tool to pinpoint the dominant failure mechanism that is associated with such a phenomenon of considerable strength increase or decrease.

75 FR 80425 - Satellite Television Extension and Localism Act of 2010 and Satellite Home Viewer Extension and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... comment the submission of additional information concerning the methodological changes for the digital... additional information concerning the methodological changes suggested in the comments by Mr. Shumate for the...-loss. The Commission is requesting a detailed description of the methodological changes that would be...

78 FR 21159 - Additional Requirements for Special Dipping and Coating Operations (Dip Tanks); Extension of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

...] Additional Requirements for Special Dipping and Coating Operations (Dip Tanks); Extension of the Office of Management and Budget's Approval of the Information Collection (Paperwork) Requirement AGENCY: Occupational... requirement specified in its Standard on Dipping and Coating Operations (Dip Tanks) (29 CFR 1910.126(g)(4...

78 FR 69812 - Federal Acquisition Regulation; Ending Trafficking in Persons; Extension of Time for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-21

...-AM55 Federal Acquisition Regulation; Ending Trafficking in Persons; Extension of Time for Comments... comment period is being extended to provide additional time for interested parties to provide comments for... 78 FR 59317, September 26, 2013. The comment period is extended to provide additional time for...

Biomechanical testing of a PEEK-based dynamic instrumentation device in a lumbar spine model.

PubMed

Herren, Christian; Beckmann, Agnes; Meyer, Sabine; Pishnamaz, Miguel; Mundt, Marion; Sobottke, Rolf; Prescher, Andreas; Stoffel, Marcus; Markert, Bernd; Kobbe, Philipp; Pape, Hans-Christoph; Eysel, Peer; Siewe, Jan

2017-05-01

The purpose of this study was to investigate the range-of-motion after posterior polyetheretherketone-based rod stabilisation combined with a dynamic silicone hinge in order to compare it with titanium rigid stabilisation. Five human cadaveric lumbar spines with four vertebra each (L2 to L5) were tested in a temperature adjustable spine-testing set-up in four trials: (1) native measurement; (2) kinematics after rigid monosegmental titanium rod instrumentation with anterior intervertebral bracing of the segment L4/5; (3) kinematics after hybrid posterior polyetheretherketone rod instrumentation combined with a silicone hinge within the adjacent level (L3/4) and (4) kinematics after additional decompression with laminectomy of L4 and bilateral resection of the inferior articular processes (L3). During all steps, the specimens were loaded quasi-statically with 1°/s with pure moment up to 7.5Nm in flexion/extension, lateral bending and axial rotation. In comparison to the native cadaveric spine, both the titanium device and polyetheretherketone-based device reduce the range-of-motion within the level L4/5 significantly (flexion/extension: reduction of 77%, p<0.001; lateral bending: reduction of 62%, p<0.001; axial rotation: reduction of 71%, p<0.001). There was a clear stabilisation effect after hybrid-instrumentation within the level L3/4, especially in flexion/extension (64%, p<0.001) and lateral bending (62%, p<0.001) but without any effect on the axial rotation. Any temperature dependency has not been observed. Surprisingly, the hybrid device compensates for laminectomy L4 and destabilising procedure within the level L3/4 in comparison to other implants. Further studies must be performed to show its effectiveness regarding the adjacent segment instability. Copyright © 2017 Elsevier Ltd. All rights reserved.

Postencephalitic focal retrograde amnesia after bilateral anterior temporal lobe damage.

PubMed

Tanaka, Y; Miyazawa, Y; Hashimoto, R; Nakano, I; Obayashi, T

1999-07-22

Marked retrograde amnesia with no or almost no anterograde amnesia is rare. Recently, a combination of ventrolateral prefrontal and temporopolar cortical lesions has been suggested as the cause of such isolated or focal retrograde amnesia. It is also assumed that when the right-sided cortical structures are damaged, autobiographical episodic memories are affected. To search for new anatomic substrates for focal retrograde amnesia. We performed extensive neuropsychological tests and obtained detailed neuroimages on a 43-year-old woman who showed a severe, persistent retrograde amnesia but only a limited anterograde amnesia after probable herpes simplex encephalitis. Tests of autobiographical memory revealed that she had a memory loss extending back to her childhood for both semantics and incidents; however, the ability to recall specific episodes appeared much more severely impaired than the ability to recall factual information about her past. The patient also showed profound impairments in recalling public memories; however, her scores improved nearly to a control level on forced-choice recognition memory tasks, although the recall of memories for a decade just before her illness remained mildly impaired. MRI revealed focal pathologies in the temporal poles and the anterior parts of the inferotemporal lobes on both sides, predominantly on the left, with some extension to the anterior parts of the medial temporal lobes. There was additional damage to the left insular cortex and its surrounding structures but no evidence of frontal lobe damage on MRIs or cognitive tests. A profound retrograde amnesia may be produced by damage to the bilateral temporal poles and anterior inferotemporal lobes in the absence of frontal lobe pathologies, and a dense and persistent episodic old memory loss can arise even with a relatively small lesion in the right anterior temporal lobe if it is combined with extensive damage to the left.

Space Suit Portable Life Support System (PLSS) 2.0 Unmanned Vacuum Environment Testing

NASA Technical Reports Server (NTRS)

Watts, Carly; Vogel, Matthew

2016-01-01

For the first time in more than 30 years, an advanced space suit Portable Life Support System (PLSS) design was operated inside a vacuum chamber representative of the flight operating environment. The test article, PLSS 2.0, was the second system-level integrated prototype of the advanced PLSS design, following the PLSS 1.0 Breadboard that was developed and tested throughout 2011. Whereas PLSS 1.0 included five technology development components with the balance the system simulated using commercial-off-the-shelf items, PLSS 2.0 featured first generation or later prototypes for all components less instrumentation, tubing and fittings. Developed throughout 2012, PLSS 2.0 was the first attempt to package the system into a flight-like representative volume. PLSS 2.0 testing included an extensive functional evaluation known as Pre-Installation Acceptance (PIA) testing, Human-in-the-Loop testing in which the PLSS 2.0 prototype was integrated via umbilicals to a manned prototype space suit for 19 two-hour simulated EVAs, and unmanned vacuum environment testing. Unmanned vacuum environment testing took place from 1/9/15-7/9/15 with PLSS 2.0 located inside a vacuum chamber. Test sequences included performance mapping of several components, carbon dioxide removal evaluations at simulated intravehicular activity (IVA) conditions, a regulator pressure schedule assessment, and culminated with 25 simulated extravehicular activities (EVAs). During the unmanned vacuum environment test series, PLSS 2.0 accumulated 378 hours of integrated testing including 291 hours of operation in a vacuum environment and 199 hours of simulated EVA time. The PLSS prototype performed nominally throughout the test series, with two notable exceptions including a pump failure and a Spacesuit Water Membrane Evaporator (SWME) leak, for which post-test failure investigations were performed. In addition to generating an extensive database of PLSS 2.0 performance data, achievements included requirements and operational concepts verification, as well as demonstration of vehicular interfaces, consumables sizing and recharge, and water quality control.

Fusion materials high energy-neutron studies. A status report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doran, D.G.; Guinan, M.W.

1980-01-01

The objectives of this paper are (1) to provide background information on the US Magnetic Fusion Reactor Materials Program, (2) to provide a framework for evaluating nuclear data needs associated with high energy neutron irradiations, and (3) to show the current status of relevant high energy neutron studies. Since the last symposium, the greatest strides in cross section development have been taken in those areas providing FMIT design data, e.g., source description, shielding, and activation. In addition, many dosimetry cross sections have been tentatively extrapolated to 40 MeV and integral testing begun. Extensive total helium measurements have been made inmore » a variety of neutron spectra. Additional calculations are needed to assist in determining energy dependent cross sections.« less

Muscle contributions to knee extension in the early stance phase in patients with knee osteoarthritis.

PubMed

Ogaya, Shinya; Kubota, Ryo; Chujo, Yuta; Hirooka, Eiko; Kwang-Ho, Kim; Hase, Kimitaka

2017-10-01

The aim of this study was to analyze individual muscle contributions to knee angular acceleration using a musculoskeletal simulation analysis and evaluate knee extension mechanics in the early stance phase in patients with knee osteoarthritis (OA). The subjects comprised 15 patients with medial knee OA and 14 healthy elderly individuals. All participants underwent gait performance test using 8 infrared cameras and two force plates to measure the kinetic and kinematic data. The simulation was driven by 92 Hill-type muscle-tendon units of the lower extremities and a trunk with 23° of freedom. We analyzed each muscle contribution to knee angular acceleration in the 5%-15% and 15%-25% periods of the stance phase (% SP) using an induced acceleration analysis. We compared accelerations by individual muscles between the two groups using an analysis of covariance for controlling gait speed. Patients with knee OA had a significantly lesser knee extension acceleration by the vasti muscles and higher knee acceleration by hip adductors than those in controls in 5-15% SP. In addition, knee OA resulted in significantly lesser knee extension acceleration by the vasti muscles in 15-25% SP. These results indicate that patients with knee OA have decreased dependency on the vasti muscles to control knee movements during early stance phase. Hip adductor muscles, which mainly control mediolateral motion, partly compensate for the weak knee extension by the vasti muscles in patients with knee OA. Copyright © 2017 Elsevier B.V. All rights reserved.

Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity

PubMed Central

Motomura, Yuki; Kitamura, Shingo; Nakazaki, Kyoko; Oba, Kentaro; Katsunuma, Ruri; Terasawa, Yuri; Hida, Akiko; Moriguchi, Yoshiya; Mishima, Kazuo

2017-01-01

Many modern people suffer from sleep debt that has accumulated in everyday life but is not subjectively noticed [potential sleep debt (PSD)]. Our hypothesis for this study was that resolution of PSD through sleep extension optimizes mood regulation by altering the functional connectivity between the amygdala and prefrontal cortex. Fifteen healthy male participants underwent an experiment consisting of a baseline (BL) evaluation followed by two successive interventions, namely, a 9-day sleep extension followed by one night of total sleep deprivation (TSD). Tests performed before and after the interventions included a questionnaire on negative mood and neuroimaging with arterial spin labeling MRI for evaluating regional cerebral blood flow (rCBF) and functional connectivity. Negative mood and amygdala rCBF were significantly reduced after sleep extension compared with BL. The amygdala had a significant negative functional connectivity with the medial prefrontal cortex (FCamg–MPFC), and this negative connectivity was greater after sleep extension than at BL. After TSD, these indices reverted to the same level as at BL. An additional path analysis with structural equation modeling showed that the FCamg–MPFC significantly explained the amygdala rCBF and that the amygdala rCBF significantly explained the negative mood. These findings suggest that the use of our sleep extension protocol normalized amygdala activity via negative amygdala–MPFC functional connectivity. The resolution of unnoticed PSD may improve mood by enhancing frontal suppression of hyperactivity in the amygdala caused by PSD accumulating in everyday life. PMID:28713328

77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation of Comprehensive... Program for Negotiation of Comprehensive Small Business Subcontracting Plans. DATES: Effective Date... Fiscal Year 2012, (Pub. L. 112-81). Section 866 amends the DoD Test Program for Negotiation of...

Pre-Gas Drilling Drinking Water Testing--An Educational Opportunity for Extension

ERIC Educational Resources Information Center

Swistock, Brian; Clark, James

2015-01-01

The increase in shale gas drilling in Pennsylvania has resulted in thousands of landowners receiving predrilling testing of their drinking water. Landowners often have difficulty understanding test reports resulting in low awareness of pre-existing problems. Extension and several partners developed a program to improve understanding of…

Maximum Likelihood Item Easiness Models for Test Theory Without an Answer Key

PubMed Central

Batchelder, William H.

2014-01-01

Cultural consensus theory (CCT) is a data aggregation technique with many applications in the social and behavioral sciences. We describe the intuition and theory behind a set of CCT models for continuous type data using maximum likelihood inference methodology. We describe how bias parameters can be incorporated into these models. We introduce two extensions to the basic model in order to account for item rating easiness/difficulty. The first extension is a multiplicative model and the second is an additive model. We show how the multiplicative model is related to the Rasch model. We describe several maximum-likelihood estimation procedures for the models and discuss issues of model fit and identifiability. We describe how the CCT models could be used to give alternative consensus-based measures of reliability. We demonstrate the utility of both the basic and extended models on a set of essay rating data and give ideas for future research. PMID:29795812

Measuring and modeling salience with the theory of visual attention.

PubMed

Krüger, Alexander; Tünnermann, Jan; Scharlau, Ingrid

2017-08-01

For almost three decades, the theory of visual attention (TVA) has been successful in mathematically describing and explaining a wide variety of phenomena in visual selection and recognition with high quantitative precision. Interestingly, the influence of feature contrast on attention has been included in TVA only recently, although it has been extensively studied outside the TVA framework. The present approach further develops this extension of TVA's scope by measuring and modeling salience. An empirical measure of salience is achieved by linking different (orientation and luminance) contrasts to a TVA parameter. In the modeling part, the function relating feature contrasts to salience is described mathematically and tested against alternatives by Bayesian model comparison. This model comparison reveals that the power function is an appropriate model of salience growth in the dimensions of orientation and luminance contrast. Furthermore, if contrasts from the two dimensions are combined, salience adds up additively.

Hippocampal damage causes retrograde but not anterograde memory loss for context fear discrimination in rats.

PubMed

Lee, Justin Q; Sutherland, Robert J; McDonald, Robert J

2017-09-01

There is a substantial body of evidence that the hippocampus (HPC) plays and essential role in context discrimination in rodents. Studies reporting anterograde amnesia (AA) used repeated, alternating, distributed conditioning and extinction sessions to measure context fear discrimination. In addition, there is uncertainty about the extent of damage to the HPC. Here, we induced conditioned fear prior to discrimination tests and rats sustained extensive, quantified pre- or post-training HPC damage. Unlike previous work, we found that extensive HPC damage spares context discrimination, we observed no AA. There must be a non-HPC system that can acquire long-term memories that support context fear discrimination. Post-training HPC damage caused retrograde amnesia (RA) for context discrimination, even when rats are fear conditioned for multiple sessions. We discuss the implications of these findings for understanding the role of HPC in long-term memory. © 2017 Wiley Periodicals, Inc.

Modular experimental platform for science and applications

NASA Technical Reports Server (NTRS)

Hill, A. S.

1984-01-01

A modularized, standardized spacecraft bus, known as MESA, suitable for a variety of science and applications missions is discussed. The basic bus consists of a simple structural arrangement housing attitude control, telemetry/command, electrical power, propulsion and thermal control subsystems. The general arrangement allows extensive subsystem adaptation to mission needs. Kits provide for the addition of tape recorders, increased power levels and propulsion growth. Both 3-axis and spin stabilized flight proven attitude control subsystems are available. The MESA bus can be launched on Ariane, as a secondary payload for low cost, or on the STS with a PAM-D or other suitable upper stage. Multi-spacecraft launches are possible with either booster. Launch vehicle integration is simple and cost-effective. The low cost of the MESA bus is achieved by the extensive utilization of existing subsystem design concepts and equipment, and efficient program management and test integration techniques.

15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

Code of Federal Regulations, 2013 CFR

2013-01-01

... OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION PARTNERSHIP; ENVIRONMENTAL PROJECTS... information, NIST manufacturing extension efforts, EPA regulation and guidance, and state requirements. The... addition, consultants providing services to those businesses, the NIST Manufacturing Extension Centers, and...

15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

Code of Federal Regulations, 2012 CFR

2012-01-01

... OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION PARTNERSHIP; ENVIRONMENTAL PROJECTS... information, NIST manufacturing extension efforts, EPA regulation and guidance, and state requirements. The... addition, consultants providing services to those businesses, the NIST Manufacturing Extension Centers, and...

15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

Code of Federal Regulations, 2014 CFR

2014-01-01

... OF COMMERCE NIST EXTRAMURAL PROGRAMS MANUFACTURING EXTENSION PARTNERSHIP; ENVIRONMENTAL PROJECTS... information, NIST manufacturing extension efforts, EPA regulation and guidance, and state requirements. The... addition, consultants providing services to those businesses, the NIST Manufacturing Extension Centers, and...

Effects of Acute Fatigue of the Hip Flexor Muscles on Hamstring Muscle Extensibility.

PubMed

Muyor, José M; Arrabal-Campos, Francisco M

2016-12-01

The purpose of the present study was to evaluate the influence of acute fatigue of the hip flexor muscles on scores attained in tests frequently used in literature to measure hamstring muscle extensibility, namely the passive straight leg raise (PSLR), active straight leg raise (ASLR), passive knee extension (PKE), active knee extension (AKE), sit-and-reach (SR) and toe-touch (TT) tests. A total of seventy-five healthy and recreationally active adults voluntarily participated in this study. To reach fatigue, the participants actively lifted their legs alternately as many times as possible. In the passive tests, the results were 7.10 ± 5.21° and 5.68 ± 4.54° higher (p < 0.01) for PSLR and PKE tests, respectively, after acute fatigue. However, in the ASLR test, the results were lower post-fatigue than pre-fatigue (mean difference = -5.30° ± 9.51°; p < 0.01). The AKE, SR and TT tests did not show significant differences between pre- and post-fatigue (p > 0.05). Moderate (r = 0.40) to high (r = 0.97) correlation coefficients were found, which were statistically significant among all the measured flexibility tests both pre- and post-fatigue. In conclusion, the active implication of the hip flexor muscles until reaching fatigue had acute influences on the results of the PSLR, PKE and ASLR tests, but not on the results of the AKE, SR and TT tests. It is recommended to use the AKE test to assess hamstring muscle extensibility in situations where athletes show fatigue in their hip flexor muscles.

Normal neurodynamic responses of the femoral slump test.

PubMed

Lai, Weng-Hang; Shih, Yi-Fen; Lin, Pei-Ling; Chen, Wen-Yin; Ma, Hsiao-Li

2012-04-01

Femoral slump test is a neurodynamic testing, which could be used to assess the mechanosensitivity of the femoral component of the nervous system. Although Trainor and Pinnington reported the diagnosis accuracy of the femoral slump test, the neurodynamic responses of the femoral slump test have never been studied. The purposes of this study were to evaluate whether maneuvers that changed the nerve tension altered the responses of the femoral slump test and if these responses were influenced by gender and leg dominance; and to identify the correlations between flexibility and measured hip extension angle. Thirty-two asymptomatic subjects (16 males, 16 females) were recruited. The femoral slump test was performed in trunk slump and neutral positions, and cervical extension was used as the structure differential technique. Hip extension angle and visual analog scale (VAS) of thigh pain was measured during the test. Our results showed the decrease of nerve tension significantly increased hip extension ROM (P < 0.001) and lowered pain intensity (P < 0.001). The hip extension ROM was similar between genders but smaller for the dominant leg, as compared to the non-dominant side (P < 0.05); and the hip ROM did not correlate with any of the flexibility indices (P > 0.05). These findings indicated that femoral slump test resulted in normal neurodynamic responses in individuals free of lower extremity problems, and these responses were independent of the influence of muscle flexibility or gender. Future research should emphasize the use of femoral slump test in patient groups such as low back and anterior knee pain. Copyright © 2011 Elsevier Ltd. All rights reserved.

Joint Eglin Acoustic Week III Data Report

NASA Technical Reports Server (NTRS)

Watts, Michael E.; Conner, David A.; Smith, Charles D.

2010-01-01

A series of three flight tests have been conducted at an Eglin Air Force Base remote test range located in the Florida panhandle. The first was the "Acoustics Week" flight test conducted in September 2003. The second was the NASA Heavy Lift Rotorcraft Acoustic Flight Test conducted in October-November 2005. The most recent was the Eglin Acoustic Week III test conducted in August-September 2007. This series of tests acquired acoustic data for a number of rotary and fixed wing aircraft and are used to generate noise semi-spheres used in predicting the acoustic footprint for prescribed flight operations. This extensive database can be used to determine the impact of flight operations on communities around a terminal area as well as for prediction code validations. Another valuable use of the semi-spheres is determining the long-range propagation of noise for civilian and military purposes. This paper describes the third test in this series. Data described in this report were acquired during testing of the MD-902 and Mi-8M aircraft. In addition, data acquired during a set of atmospheric propagation tests is also described.

The Advanced Solid Rocket Motor

NASA Technical Reports Server (NTRS)

Mitchell, Royce E.

1992-01-01

The Advanced Solid Rocket Motor will utilize improved design features and automated manufacturing methods to produce an inherently safer propulsive system for the Space Shuttle and future launch systems. This second-generation motor will also provide an additional 12,000 pounds of payload to orbit, enhancing the utility and efficiency of the Shuttle system. The new plant will feature strip-wound, asbestos-free insulation; propellant continuous mixing and casting; and extensive robotic systems. Following a series of static tests at the Stennis Space Center, MS flights are targeted to begin in early 1997.

Fabrication and evaluation of low fiber content alumina fiber/aluminum composites

NASA Technical Reports Server (NTRS)

Hack, J. E.; Strempek, G. C.

1980-01-01

The mechanical fabrication of low volume percent fiber, polycrystalline alumina fiber reinforced aluminum composites was accomplished. Wire preform material was prepared by liquid-metal infiltration of alumina fiber bundles. The wires were subsequently encapsulated with aluminum foil and fabricated into bulk composite material by hot-drawing. Extensive mechanical, thermal and chemical testing was conducted on preform and bulk material to develop a process and material data base. In addition, a preliminary investigation of mechanical forming of bulk alumina fiber reinforced aluminum composite material was conducted.

LIVVkit: An extensible, python-based, land ice verification and validation toolkit for ice sheet models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kennedy, Joseph H.; Bennett, Andrew R.; Evans, Katherine J.

To address the pressing need to better understand the behavior and complex interaction of ice sheets within the global Earth system, significant development of continental-scale, dynamical ice sheet models is underway. Concurrent to the development of the Community Ice Sheet Model (CISM), the corresponding verification and validation (V&V) process is being coordinated through a new, robust, Python-based extensible software package, the Land Ice Verification and Validation toolkit (LIVVkit). Incorporated into the typical ice sheet model development cycle, it provides robust and automated numerical verification, software verification, performance validation, and physical validation analyses on a variety of platforms, from personal laptopsmore » to the largest supercomputers. LIVVkit operates on sets of regression test and reference data sets, and provides comparisons for a suite of community prioritized tests, including configuration and parameter variations, bit-for-bit evaluation, and plots of model variables to indicate where differences occur. LIVVkit also provides an easily extensible framework to incorporate and analyze results of new intercomparison projects, new observation data, and new computing platforms. LIVVkit is designed for quick adaptation to additional ice sheet models via abstraction of model specific code, functions, and configurations into an ice sheet model description bundle outside the main LIVVkit structure. Furthermore, through shareable and accessible analysis output, LIVVkit is intended to help developers build confidence in their models and enhance the credibility of ice sheet models overall.« less

LIVVkit: An extensible, python-based, land ice verification and validation toolkit for ice sheet models

DOE PAGES

Kennedy, Joseph H.; Bennett, Andrew R.; Evans, Katherine J.; ...

2017-03-23

To address the pressing need to better understand the behavior and complex interaction of ice sheets within the global Earth system, significant development of continental-scale, dynamical ice sheet models is underway. Concurrent to the development of the Community Ice Sheet Model (CISM), the corresponding verification and validation (V&V) process is being coordinated through a new, robust, Python-based extensible software package, the Land Ice Verification and Validation toolkit (LIVVkit). Incorporated into the typical ice sheet model development cycle, it provides robust and automated numerical verification, software verification, performance validation, and physical validation analyses on a variety of platforms, from personal laptopsmore » to the largest supercomputers. LIVVkit operates on sets of regression test and reference data sets, and provides comparisons for a suite of community prioritized tests, including configuration and parameter variations, bit-for-bit evaluation, and plots of model variables to indicate where differences occur. LIVVkit also provides an easily extensible framework to incorporate and analyze results of new intercomparison projects, new observation data, and new computing platforms. LIVVkit is designed for quick adaptation to additional ice sheet models via abstraction of model specific code, functions, and configurations into an ice sheet model description bundle outside the main LIVVkit structure. Furthermore, through shareable and accessible analysis output, LIVVkit is intended to help developers build confidence in their models and enhance the credibility of ice sheet models overall.« less

High Density Aerial Image Matching: State-Of and Future Prospects

NASA Astrophysics Data System (ADS)

Haala, N.; Cavegn, S.

2016-06-01

Ongoing innovations in matching algorithms are continuously improving the quality of geometric surface representations generated automatically from aerial images. This development motivated the launch of the joint ISPRS/EuroSDR project "Benchmark on High Density Aerial Image Matching", which aims on the evaluation of photogrammetric 3D data capture in view of the current developments in dense multi-view stereo-image matching. Originally, the test aimed on image based DSM computation from conventional aerial image flights for different landuse and image block configurations. The second phase then put an additional focus on high quality, high resolution 3D geometric data capture in complex urban areas. This includes both the extension of the test scenario to oblique aerial image flights as well as the generation of filtered point clouds as additional output of the respective multi-view reconstruction. The paper uses the preliminary outcomes of the benchmark to demonstrate the state-of-the-art in airborne image matching with a special focus of high quality geometric data capture in urban scenarios.

Safety behavior: Job demands, job resources, and perceived management commitment to safety.

PubMed

Hansez, Isabelle; Chmiel, Nik

2010-07-01

The job demands-resources model posits that job demands and resources influence outcomes through job strain and work engagement processes. We test whether the model can be extended to effort-related "routine" safety violations and "situational" safety violations provoked by the organization. In addition we test more directly the involvement of job strain than previous studies which have used burnout measures. Structural equation modeling provided, for the first time, evidence of predicted relationships between job strain and "routine" violations and work engagement with "routine" and "situational" violations, thereby supporting the extension of the job demands-resources model to safety behaviors. In addition our results showed that a key safety-specific construct 'perceived management commitment to safety' added to the explanatory power of the job demands-resources model. A predicted path from job resources to perceived management commitment to safety was highly significant, supporting the view that job resources can influence safety behavior through both general motivational involvement in work (work engagement) and through safety-specific processes.

Space Environmental Effects Testing Capability at the Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

DeWittBurns, H.; Craven, Paul; Finckenor, Miria; Nehls, Mary; Schneider, Todd; Vaughn, Jason

2012-01-01

Understanding the effects of the space environment on materials and systems is fundamental and essential for mission success. If not properly understood and designed for, the effects of the environment can lead to degradation of materials, reduction of functional lifetime, and system failure. In response to this need, the Marshall Space Flight Center has developed world class Space Environmental Effects (SEE) expertise and test facilities to simulate the space environment. Capabilities include multiple unique test systems comprising the most complete SEE testing capability available. These test capabilities include charged particle radiation (electrons, protons, ions), ultraviolet radiation (UV), vacuum ultraviolet radiation (VUV), atomic oxygen, plasma effects, space craft charging, lunar surface and planetary effects, vacuum effects, and hypervelocity impacts as well as the combination of these capabilities. In addition to the uniqueness of the individual test capabilities, MSFC is the only NASA facility where the effects of the different space environments can be tested in one location. Combined with additional analytical capabilities for pre- and post-test evaluation, MSFC is a one-stop shop for materials testing and analysis. The SEE testing and analysis are performed by a team of award winning experts nationally recognized for their contributions in the study of the effects of the space environment on materials and systems. With this broad expertise in space environmental effects and the variety of test systems and equipment available, MSFC is able to customize tests with a demonstrated ability to rapidly adapt and reconfigure systems to meet customers needs. Extensive flight experiment experience bolsters this simulation and analysis capability with a comprehensive understanding of space environmental effects.

Reynolds number effects on the aerodynamic characteristics of irregular planform wings at Mach number 0.3. [in the Ames 12 ft pressure wind tunnel

NASA Technical Reports Server (NTRS)

Kruse, R. L.; Lovette, G. H.; Spencer, B., Jr.

1977-01-01

The subsonic aerodynamic characteristics of a series of irregular planform wings were studied in wind tunnel tests conducted at M = 0.3 over a range of Reynolds numbers from 1.6 million to 26 million/m. The five basic wing planforms varied from a trapezoidal to a delta shape. Leading edge extensions, added to the basic shape, varied in approximately 5 deg increments from the wing leading edge sweep-back angle to a maximum 80 deg. Most of the tests were conducted using an NACA 0008 airfoil section with grit boundary layer trips. Tests were also conducted using an NACA 0012 airfoil section and an 8% thick wedge. In addition, the effect of free transition (no grit) was investigated. A body was used on all models.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Windisch, C.F. Jr.; Strachan, D.M.; Henager, C.H. Jr.

Cermet anodes were evaluated as nonconsumable substitutes for carbon anodes using a pilot-scale reduction cell at the Reynolds Manufacturing Technology Laboratory. After pilot cell testing, tile anodes were subjected to extensive materials characterization and physical properties measurements at the Pacific Northwest Laboratory. Significant changes in the composition of the cermet anodes were observed including the growth of a reaction layer and penetration of electrolyte deep into the cermet matrix. Fracture strength and toughness were measured as a function of temperature and the ductile-brittle transition wasreduced by 500C following pilot cell testing. These results imply difficulties with anode material and controlmore » of operating conditions in the pilot cell, and suggest that additional development work be performed before the cermet anodes are used in commercial reduction cells. The results also highlight specific fabrication and operational considerations that should be addressed in future testing.« less

JT8D revised high-pressure turbine cooling and other outer air seal program

NASA Technical Reports Server (NTRS)

Gaffin, W. O.

1979-01-01

The JT8D high pressure turbine was revised to reduce leakage between the blade tip shrouds and the outer air seal, and engine testing was performed to determine the effect on performance. The addition of a second knife-edge on the blade tip shroud, the extension of the honeycomb seal land to cover the added knife-edge and an existing spoiler on the shroud, and a material substitution in the seal support ring to improve thermal growth characteristics are included. A relocation of the blade cooling air discharge to insure adequate cooling flow is required. Significant specific fuel consumption and exhaust gas temperature improvements were demonstrated with the revised turbine in sea level and simulated altitude engine tests. Inspection of the revised seal hardware after these tests showed no unusual wear or degradation.

Energy-efficient ovens for unpolluted balady bread

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gadalla, M.A.; Mansour, M.S.; Mahdy, E.

A new bread oven has been developed, tested and presented in this work for local balady bread. The design has the advantage of being efficient and producing unpolluted bread. An extensive study of the conventional and available designs has been carried out in order to help developing the new design. Evaluation of the conventional design is based on numerous tests and measurements. A computer code utilizing the indirect method has been developed to evaluate the thermal performance of the tested ovens. The present design achieves higher thermal efficiency of about 50% than the conventional ones. In addition, its capital costmore » is much cheaper than other imported designs. Thus, the present design achieves higher efficiency, pollutant free products and less cost. Moreover, it may be modified for different types of bread baking systems.« less

Inferring field-scale properties of a fractured aquifer from ground surface deformation during a well test

NASA Astrophysics Data System (ADS)

Schuite, Jonathan; Longuevergne, Laurent; Bour, Olivier; Boudin, Frédérick; Durand, Stéphane; Lavenant, Nicolas

2015-12-01

Fractured aquifers which bear valuable water resources are often difficult to characterize with classical hydrogeological tools due to their intrinsic heterogeneities. Here we implement ground surface deformation tools (tiltmetry and optical leveling) to monitor groundwater pressure changes induced by a classical hydraulic test at the Ploemeur observatory. By jointly analyzing complementary time constraining data (tilt) and spatially constraining data (vertical displacement), our results strongly suggest that the use of these surface deformation observations allows for estimating storativity and structural properties (dip, root depth, and lateral extension) of a large hydraulically active fracture, in good agreement with previous studies. Hence, we demonstrate that ground surface deformation is a useful addition to traditional hydrogeological techniques and opens possibilities for characterizing important large-scale properties of fractured aquifers with short-term well tests as a controlled forcing.

Heavy Gas Conversion of the NASA Langley Transonic Dynamics Tunnel

NASA Technical Reports Server (NTRS)

Corliss, James M.; Cole, Stanley, R.

1998-01-01

The heavy gas test medium has recently been changed in the Transonic Dynamics Tunnel (TDT) at the NASA Langley Research Center. A NASA Construction of Facilities project has converted the TDT heavy gas from dichlorodifluoromethane (R12) to 1,1,1,2 tetrafluoroethane (R134a). The facility s heavy gas processing system was extensively modified to implement the conversion to R134a. Additional system modifications have improved operator interfaces, hardware reliability, and quality of the research data. The facility modifications included improvements to the heavy gas compressor and piping, the cryogenic heavy gas reclamation system, and the heavy gas control room. A series of wind tunnel characterization and calibration tests are underway. Results of the flow characterization tests show the TDT operating envelope in R134a to be very similar to the previous operating envelope in R12.

Assessment of Isometric Trunk Strength - The Relevance of Body Position and Relationship between Planes of Movement.

PubMed

Kocjan, Andrej; Sarabon, Nejc

2014-05-01

The aim of the study was to assess the differences in maximal isometric trunk extension and flexion strength during standing, sitting and kneeling. Additionally, we were interested in correlations between the maximal strength in sagittal, frontal and transverse plane, measured in the sitting position. Sixty healthy subjects (24 male, 36 female; age 41.3 ± 15.1 yrs; body height 1.70 ± 0.09 m; body mass 72.7 ± 13.3 kg) performed maximal voluntary isometric contractions of the trunk flexor and extensor muscles in standing, sitting and kneeling position. The subjects also performed lateral flexions and rotations in the sitting position. Each task was repeated three times and average of maximal forces was used for data analysis. RANOVA with post-hoc testing was applied to the flexion and extension data. The level of statistical significance was set to p < 0.05. Overall, in both genders together, the highest average force for trunk extension was recorded in sitting posture (910.5 ± 271.5 N), followed by kneeling (834.3 ± 242.9 N) and standing (504.0 ± 165.4 N), compared with flexion, where we observed the opposite trend (508.5 ± 213.0 N, 450.9 ± 165.7 N and 443.4 ± 153.1 N, respectively). Post-hoc tests showed significant differences in all extension positions (p < 0.0001) and between sitting/standing (p = 0.018) and kneeling/standing (p = 0.033) flexion exertions. The extension/flexion ratio for sitting was 2.1 ± 0.4, for kneeling 1.9 ± 0.4, followed by standing, where motion forward approximately equals motion backward (1.1 ± 0.6). Trunk sagittal-transverse strength showed the strongest correlation, followed by frontal-transverse and sagittal-frontal plane correlation pairs (R(2) = 0.830, 0.712 and 0.657). The baseline trunk isometric strength data provided by this study should help further strength diagnostics, more precisely, the prevention of low back disorders. Key pointsMaximal voluntary isometric force of the trunk extensors increased with the angle at the hips (highest in sitting, medium in kneeling and lowest in upright standing).The opposite trend was true for isometric MVC force of trunk flexors (both genders together and men only).In the sitting position, the strongest correlation between MVC forces was found between sagittal (average flexion/extension) and transverse plane (average left/right rotation).IN ORDER TO INCREASE THE VALIDITY OF TRUNK STRENGTH TESTING THE LETTER SHOULD INCLUDE: specific warm-up, good pelvic fixation and visual feedback.

Assessment of Isometric Trunk Strength – The Relevance of Body Position and Relationship between Planes of Movement

PubMed Central

Kocjan, Andrej; Sarabon, Nejc

2014-01-01

The aim of the study was to assess the differences in maximal isometric trunk extension and flexion strength during standing, sitting and kneeling. Additionally, we were interested in correlations between the maximal strength in sagittal, frontal and transverse plane, measured in the sitting position. Sixty healthy subjects (24 male, 36 female; age 41.3 ± 15.1 yrs; body height 1.70 ± 0.09 m; body mass 72.7 ± 13.3 kg) performed maximal voluntary isometric contractions of the trunk flexor and extensor muscles in standing, sitting and kneeling position. The subjects also performed lateral flexions and rotations in the sitting position. Each task was repeated three times and average of maximal forces was used for data analysis. RANOVA with post-hoc testing was applied to the flexion and extension data. The level of statistical significance was set to p < 0.05. Overall, in both genders together, the highest average force for trunk extension was recorded in sitting posture (910.5 ± 271.5 N), followed by kneeling (834.3 ± 242.9 N) and standing (504.0 ± 165.4 N), compared with flexion, where we observed the opposite trend (508.5 ± 213.0 N, 450.9 ± 165.7 N and 443.4 ± 153.1 N, respectively). Post-hoc tests showed significant differences in all extension positions (p < 0.0001) and between sitting/standing (p = 0.018) and kneeling/standing (p = 0.033) flexion exertions. The extension/flexion ratio for sitting was 2.1 ± 0.4, for kneeling 1.9 ± 0.4, followed by standing, where motion forward approximately equals motion backward (1.1 ± 0.6). Trunk sagittal-transverse strength showed the strongest correlation, followed by frontal-transverse and sagittal-frontal plane correlation pairs (R2 = 0.830, 0.712 and 0.657). The baseline trunk isometric strength data provided by this study should help further strength diagnostics, more precisely, the prevention of low back disorders. Key points Maximal voluntary isometric force of the trunk extensors increased with the angle at the hips (highest in sitting, medium in kneeling and lowest in upright standing). The opposite trend was true for isometric MVC force of trunk flexors (both genders together and men only). In the sitting position, the strongest correlation between MVC forces was found between sagittal (average flexion/extension) and transverse plane (average left/right rotation). In order to increase the validity of trunk strength testing the letter should include: specific warm-up, good pelvic fixation and visual feedback. PMID:24790491

77 FR 38289 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... comment for 30 days to revise, without extension, Capital Assessments and Stress Testing information..., without extension, the Capital Assessments and Stress Testing information collection (FR Y-14A/Q/M). In...

76 FR 24060 - Proposed Extension of Existing Information Collection; Testing, Evaluation, and Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... Extension of Existing Information Collection; Testing, Evaluation, and Approval of Mining Products AGENCY... Reduction Act of 1995 [44 U.S.C. 3506(c)(2)(A)]. This program helps to ensure that requested data can be..., testing, approval and certification, and quality control of mining equipment and components, materials...

PHENIX Muon Piston Calorimeter (MPC) APD and Prototype MPC Extension (MPC-EX) Tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lajoie, John

2013-06-20

This is a technical scope of work (TSW) between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Muon Piston Calorimeter Extension (MPC-EX) Collaboration who have committed to participate in beam tests to be carried out during the 2013- 2014 Fermilab Test Beam Facility program.

Fixating picture boundaries does not eliminate boundary extension: Implications for scene representation

PubMed Central

Gagnier, Kristin Michod; Dickinson, Christopher A.; Intraub, Helene

2015-01-01

Observers frequently remember seeing more of a scene than was shown (boundary extension). Does this reflect a lack of eye fixations to the boundary region? Single-object photographs were presented for 14–15 s each. Main objects were either whole or slightly cropped by one boundary, creating a salient marker of boundary placement. All participants expected a memory test, but only half were informed that boundary memory would be tested. Participants in both conditions made multiple fixations to the boundary region and the cropped region during study. Demonstrating the importance of these regions, test-informed participants fixated them sooner, longer, and more frequently. Boundary ratings (Experiment 1) and border adjustment tasks (Experiments 2–4) revealed boundary extension in both conditions. The error was reduced, but not eliminated, in the test-informed condition. Surprisingly, test knowledge and multiple fixations to the salient cropped region, during study and at test, were insufficient to overcome boundary extension on the cropped side. Results are discussed within a traditional visual-centric framework versus a multisource model of scene perception. PMID:23547787

Fixating picture boundaries does not eliminate boundary extension: implications for scene representation.

PubMed

Michod Gagnier, Kristin; Dickinson, Christopher A; Intraub, Helene

2013-01-01

Observers frequently remember seeing more of a scene than was shown (boundary extension). Does this reflect a lack of eye fixations to the boundary region? Single-object photographs were presented for 14-15 s each. Main objects were either whole or slightly cropped by one boundary, creating a salient marker of boundary placement. All participants expected a memory test, but only half were informed that boundary memory would be tested. Participants in both conditions made multiple fixations to the boundary region and the cropped region during study. Demonstrating the importance of these regions, test-informed participants fixated them sooner, longer, and more frequently. Boundary ratings (Experiment 1) and border adjustment tasks (Experiments 2-4) revealed boundary extension in both conditions. The error was reduced, but not eliminated, in the test-informed condition. Surprisingly, test knowledge and multiple fixations to the salient cropped region, during study and at test, were insufficient to overcome boundary extension on the cropped side. Results are discussed within a traditional visual-centric framework versus a multisource model of scene perception.

Overview of Non-nuclear Testing of the Safe, Affordable 30-kW Fission Engine, Including End-to-End Demonstrator Testing

NASA Technical Reports Server (NTRS)

VanDyke, M. K.; Martin, J. J.; Houts, M. G.

2003-01-01

Successful development of space fission systems will require an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. At the power levels under consideration (3-300 kW electric power), almost all technical issues are thermal or stress related and will not be strongly affected by the radiation environment. These issues can be resolved more thoroughly, less expensively, and in a more timely fashing with nonnuclear testing, provided it is prototypic of the system in question. This approach was used for the safe, affordable fission engine test article development program and accomplished viz cooperative efforts with Department of Energy labs, industry, universiites, and other NASA centers. This Technical Memorandum covers the analysis, testing, and data reduction of a 30-kW simulated reactor as well as an end-to-end demonstrator, including a power conversion system and an electric propulsion engine, the first of its kind in the United States.

Test Facilities in Support of High Power Electric Propulsion Systems

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Houts, Mike; Godfroy, Thomas; Dickens, Ricky; Martin, James J.; Salvail, Patrick; Carter, Robert

2002-01-01

Successful development of space fission systems requires an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system performance and lifetime can be attained through non-nuclear testing. Through demonstration of systems concepts (designed by DOE National Laboratories) in relevant environments, this philosophy has been demonstrated through hardware testing in the High Power Propulsion Thermal Simulator (HPPTS). The HPPTS is designed to enable very realistic non-nuclear testing of space fission systems. Ongoing research at the HPPTS is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers. Through hardware based design and testing, the HPPTS investigates High Power Electric Propulsion (HPEP) component, subsystem, and integrated system design and performance.

Cross-border outbreak of extensively drug-resistant tuberculosis linked to a university in Romania.

PubMed

Popovici, O; Monk, Ph; Chemtob, D; Chiotan, D; Freidlin, P J; Groenheit, R; Haanperä, M; Homorodean, D; Mansjö, M; Robinson, E; Rorman, E; Smith, G; Soini, H; Van Der Werf, M J

2018-05-01

Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations included tuberculin skin testing or interferon gamma release assay, chest X-ray, sputum smear microscopy, culture, drug susceptibility testing, genotyping and whole-genome sequencing (WGS), and were addressed to students, personnel of the university, family members or other close contacts of the cases. These investigations increased the total number of cases to seven. All confirmed cases shared a very similar WGS profile. Two more cases were epidemiologically linked, but no laboratory confirmation exists. Despite all the efforts done, the source of the outbreak was not identified, but the transmission was controlled. The investigation was conducted by a team including epidemiologists and microbiologists from five countries (Finland, Israel, Romania, Sweden and the UK) and from the European Centre for Disease Prevention and Control. Our report shows how countries can collaborate to control the spread of XDR TB by exchanging information about cases and their contacts to enable identification of additional cases and transmission and to perform the source investigation.

Numerical simulation of turbulent jet noise, part 2

NASA Technical Reports Server (NTRS)

Metcalfe, R. W.; Orszag, S. A.

1976-01-01

Results on the numerical simulation of jet flow fields were used to study the radiated sound field, and in addition, to extend and test the capabilities of the turbulent jet simulation codes. The principal result of the investigation was the computation of the radiated sound field from a turbulent jet. In addition, the computer codes were extended to account for the effects of compressibility and eddy viscosity, and the treatment of the nonlinear terms of the Navier-Stokes equations was modified so that they can be computed in a semi-implicit way. A summary of the flow model and a description of the numerical methods used for its solution are presented. Calculations of the radiated sound field are reported. In addition, the extensions that were made to the fundamental dynamical codes are described. Finally, the current state-of-the-art for computer simulation of turbulent jet noise is summarized.

Effect of food additives on egg yolk gelation induced by freezing.

PubMed

Primacella, Monica; Fei, Tao; Acevedo, Nuria; Wang, Tong

2018-10-15

This study demonstrates technological advances in preventing yolk gelation during freezing and thawing. Gelation negatively affects yolk functionality in food formulation. Preventing gelation using 10% salt or sugar limits the application of the yolk. Novel food additives were tested to prevent gelation induced by freezing. Significant reduction (p < 0.05) in gel hardness of frozen-thawed yolk (45 h freezing at -20 °C) indicates that hydrolyzed carboxymethyl cellulose (HCMC), proline, and hydrolyzed egg white and yolk (HEW and HEY) are effective gelation inhibitors. The mechanisms in which these additives prevented gelation were further studied through measuring the changes in the amount of freezable water, lipoprotein particle size, and protein surface hydrophobicity. Overall, this study provides several alternatives of gelation inhibitor that have great potentials in replacing the use of salt or sugar in commercial operation of freezing egg yolk for shelf-life extension. Copyright © 2018 Elsevier Ltd. All rights reserved.

Yttria catalyzed microstructural modifications in oxide dispersion strengthened V-4Cr-4Ti alloys synthesized by field assisted sintering technique

NASA Astrophysics Data System (ADS)

Krishnan, Vinoadh Kumar; Sinnaeruvadi, Kumaran; Verma, Shailendra Kumar; Dash, Biswaranjan; Agrawal, Priyanka; Subramanian, Karthikeyan

2017-08-01

The present work deals with synthesis, characterisation and elevated temperature mechanical property evaluation of V-4Cr-4Ti and oxide (yttria = 0.3, 0.6 and 0.9 at%) dispersion strengthened V-4Cr-4Ti alloy processed by mechanical alloying and field-assisted sintering, under optimal conditions. Microstructural parameters of both powder and sintered samples were deduced by X-ray diffraction (XRD) and further confirmed with high resolution transmission electron microscopy. Powder diffraction and electron microscopy study show that ball milling of starting elemental powders (V-4Cr-4Ti) with and without yttria addition has resulted in single phase α-V (V-4Cr-4Ti) alloy. Wherein, XRD and electron microscopy images of sintered samples have revealed phase separation (viz., Cr-V and Ti-V) and domain size reduction, with yttria addition. The reasons behind phase separation and domain size reduction with yttria addition during sintering are extensively discussed. Microhardness and high temperature compression tests were done on sintered samples. Yttria addition (0.3 and 0.6 at.%) increases the elevated temperature compressive strength and strain hardening exponent of α-V alloys. High temperature compression test of 0.9 at% yttria dispersed α-V alloy reveals a glassy behaviour.

High-reliable linear cryocoolers and miniaturization developments at Thales Cryogenics

NASA Astrophysics Data System (ADS)

van der Weijden, H.; Benschop, A.; v. D. Groep, W.; Willems, D.; Mullie, J.

2010-04-01

Thales Cryogenics (TCBV) has an extensive background in delivering long life cryogenic coolers for military, civil and space programs. This cooler range is based on two main compressor concepts: close tolerance contact seals (UP) and flexure bearing (LSF/LPT) coolers. Main difference between these products is the Mean Time To Failure (MTTF). In this paper an overview of lifetime parameters will be listed versus the impact in the different cooler types. Also test results from both the installed base and the Thales Cryogenics test lab will be presented. New developments at Thales Cryogenics regarding compact long lifetime coolers will be outlined. In addition new developments for miniature linear cooler drive electronics with high temperature stability and power density will be described.

Test stand for Titan 34D SRM static firing

NASA Technical Reports Server (NTRS)

Glozman, Vladimir; Shipway, George

1988-01-01

An existing liquid engine test stand at the AF Astronautics Laboratory was refurbished and extensively modified to accommodate the static firing of the Titan 34D solid rocket motor (SRM) in the vertical nozzle down orientation. The main load restraint structure was designed and built to secure the SRM from lifting off during the firing. In addition, the structure provided weather protection, temperature conditioning of the SRM, and positioning of the measurement and recording equipment. The structure was also used for stacking/de-stacking of SRM segments and other technological processes. The existing stand, its foundation and anchorage were thoroughly examined and reanalyzed. Necessary stand modifications were carried out to comply with the requirements of the Titan 34D SRM static firing.

Neural network tracking and extension of positive tracking periods

NASA Technical Reports Server (NTRS)

Hanan, Jay C.; Chao, Tien-Hsin; Moreels, Pierre

2004-01-01

Feature detectors have been considered for the role of supplying additional information to a neural network tracker. The feature detector focuses on areas of the image with significant information. Basically, if a picture says a thousand words, the feature detectors are looking for the key phrases (keypoints). These keypoints are rotationally invariant and may be matched across frames. Application of these advanced feature detectors to the neural network tracking system at JPL has promising potential. As part of an ongoing program, an advanced feature detector was tested for augmentation of a neural network based tracker. The advance feature detector extended tracking periods in test sequences including aircraft tracking, rover tracking, and simulated Martian landing. Future directions of research are also discussed.

Neural network tracking and extension of positive tracking periods

NASA Astrophysics Data System (ADS)

Hanan, Jay C.; Chao, Tien-Hsin; Moreels, Pierre

2004-04-01

Feature detectors have been considered for the role of supplying additional information to a neural network tracker. The feature detector focuses on areas of the image with significant information. Basically, if a picture says a thousand words, the feature detectors are looking for the key phrases (keypoints). These keypoints are rotationally invariant and may be matched across frames. Application of these advanced feature detectors to the neural network tracking system at JPL has promising potential. As part of an ongoing program, an advanced feature detector was tested for augmentation of a neural network based tracker. The advance feature detector extended tracking periods in test sequences including aircraft tracking, rover tracking, and simulated Martian landing. Future directions of research are also discussed.

Status and improvement of CLAM for nuclear application

NASA Astrophysics Data System (ADS)

Huang, Qunying

2017-08-01

A program for China low activation martensitic steel (CLAM) development has been underway since 2001 to satisfy the material requirements of the test blanket module (TBM) for ITER, China fusion engineering test reactor and China fusion demonstration reactor. It has been undertaken by the Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences under wide domestic and international collaborations. Extensive work and efforts are being devoted to the R&D of CLAM, such as mechanical property evaluation before and after neutron irradiation, fabrication of scaled TBM by welding and additive manufacturing, improvement of its irradiation resistance as well as high temperature properties by precipitate strengthening to achieve its final successful application in fusion systems. The status and improvement of CLAM are introduced in this paper.

XML technology planning database : lessons learned

NASA Technical Reports Server (NTRS)

Some, Raphael R.; Neff, Jon M.

2005-01-01

A hierarchical Extensible Markup Language(XML) database called XCALIBR (XML Analysis LIBRary) has been developed by Millennium Program to assist in technology investment (ROI) analysis and technology Language Capability the New return on portfolio optimization. The database contains mission requirements and technology capabilities, which are related by use of an XML dictionary. The XML dictionary codifies a standardized taxonomy for space missions, systems, subsystems and technologies. In addition to being used for ROI analysis, the database is being examined for use in project planning, tracking and documentation. During the past year, the database has moved from development into alpha testing. This paper describes the lessons learned during construction and testing of the prototype database and the motivation for moving from an XML taxonomy to a standard XML-based ontology.

Modal analysis of the human neck in vivo as a criterion for crash test dummy evaluation

NASA Astrophysics Data System (ADS)

Willinger, R.; Bourdet, N.; Fischer, R.; Le Gall, F.

2005-10-01

Low speed rear impact remains an acute automative safety problem because of a lack of knowledge of the mechanical behaviour of the human neck early after impact. Poorly validated mathematical models of the human neck or crash test dummy necks make it difficult to optimize automotive seats and head rests. In this study we have constructed an experimental and theoretical modal analysis of the human head-neck system in the sagittal plane. The method has allowed us to identify the mechanical properties of the neck and to validate a mathematical model in the frequency domain. The extracted modal characteristics consist of a first natural frequency at 1.3±0.1 Hz associated with head flexion-extension motion and a second mode at 8±0.7 Hz associated with antero-posterior translation of the head, also called retraction motion. Based on this new validation parameters we have been able to compare the human and crash test dummy frequency response functions and to evaluate their biofidelity. Three head-neck systems of current test dummies dedicated for use in rear-end car crash accident investigations have been evaluated in the frequency domain. We did not consider any to be acceptable, either because of excessive rigidity of their flexion-extension mode or because they poorly reproduce the head translation mode. In addition to dummy evaluation, this study provides new insight into injury mechanisms when a given natural frequency can be linked to a specific neck deformation.

The relationship between balance performance, lumbar extension strength, trunk extension endurance, and pain in participants with chronic low back pain, and those without.

PubMed

Behennah, Jessica; Conway, Rebecca; Fisher, James; Osborne, Neil; Steele, James

2018-03-01

Chronic low back pain is associated with lumbar extensor deconditioning. This may contribute to decreased neuromuscular control and balance. However, balance is also influenced by the hip musculature. Thus, the purpose of this study was to examine balance in both asymptomatic participants and those with chronic low back pain, and to examine the relationships among balance, lumbar extension strength, trunk extension endurance, and pain. Forty three asymptomatic participants and 21 participants with non-specific chronic low back pain underwent balance testing using the Star Excursion Balance Test, lumbar extension strength, trunk extension endurance, and pain using a visual analogue scale. Significant correlations were found between lumbar extension strength and Star Excursion Balance Test scores in the chronic low back pain group (r = 0.439-0.615) and in the asymptomatic group (r = 0.309-0.411). Correlations in the chronic low back pain group were consistently found in posterior directions. Lumbar extension strength explained ~19.3% to ~37.8% of the variance in Star Excursion Balance Test scores for the chronic low back pain group and ~9.5% to ~16.9% for the asymptomatic group. These results suggest that the lumbar extensors may be an important factor in determining the motor control dysfunctions, such as limited balance, that arise in chronic low back pain. As such, specific strengthening of this musculature may be an approach to aid in reversing these dysfunctions. Copyright © 2018 Elsevier Ltd. All rights reserved.

Quadriceps force during knee extension in different replacement scenarios with a modular partial prosthesis.

PubMed

Calliess, Tilman; Schado, Ssuheib; Richter, Berna I; Becher, Christoph; Ezechieli, Marco; Ostermeier, Sven

2014-02-01

Previous biomechanical studies have shown that bi-cruciate retaining knee replacement does not significantly alter normal knee kinematics, however, there are no data on the influence of a combined medial and patellofemoral bi-compartimental arthroplasty. The purpose of this in vitro study was to evaluate the effect of different replacement scenarios with a modular partial knee replacement system on the amount of quadriceps force required to extend the knee during an isokinetic extension cycle. Ten human knee specimens were tested in a kinematic knee simulator under (1) physiologic condition and after subsequent implantation of (2) a medial unicondylar and (3) a trochlear replacement. An isokinetic extension cycle of the knee with a constant extension moment of 31 Nm was simulated. The resulting quadriceps extension force was measured from 120° to full knee extension. The quadriceps force curve described a typically sinusoidal characteristic before and after each replacement scenario. The isolated medial replacement resulted in a slightly, but significantly higher maximum quadriceps force (1510 N vs. 1585 N, P = 0.006) as well as the subsequent trochlear replacement showed an additional increase (1801 N, P = 0.008). However, for both replacements no significant difference to the untreated condition could be detected in mid-flexion (10-50°). When considering a bi-compartimental replacement an increase of required maximum quadriceps force needed to extend the knee has to keep in mind. However, the close to physiological movement in mid-flexion suggests that patients with a bi-crutiate retaining arthroplasty might have an advantage in knee stability compared to total knee arthroplasty. Copyright © 2013 Elsevier Ltd. All rights reserved.

Cortical hypometabolism and hypoperfusion in Parkinson's disease is extensive: probably even at early disease stages.

PubMed

Borghammer, Per; Chakravarty, Mallar; Jonsdottir, Kristjana Yr; Sato, Noriko; Matsuda, Hiroshi; Ito, Kengo; Arahata, Yutaka; Kato, Takashi; Gjedde, Albert

2010-05-01

Recent cerebral blood flow (CBF) and glucose consumption (CMRglc) studies of Parkinson's disease (PD) revealed conflicting results. Using simulated data, we previously demonstrated that the often-reported subcortical hypermetabolism in PD could be explained as an artifact of biased global mean (GM) normalization, and that low-magnitude, extensive cortical hypometabolism is best detected by alternative data-driven normalization methods. Thus, we hypothesized that PD is characterized by extensive cortical hypometabolism but no concurrent widespread subcortical hypermetabolism and tested it on three independent samples of PD patients. We compared SPECT CBF images of 32 early-stage and 33 late-stage PD patients with that of 60 matched controls. We also compared PET FDG images from 23 late-stage PD patients with that of 13 controls. Three different normalization methods were compared: (1) GM normalization, (2) cerebellum normalization, (3) reference cluster normalization (Yakushev et al.). We employed standard voxel-based statistics (fMRIstat) and principal component analysis (SSM). Additionally, we performed a meta-analysis of all quantitative CBF and CMRglc studies in the literature to investigate whether the global mean (GM) values in PD are decreased. Voxel-based analysis with GM normalization and the SSM method performed similarly, i.e., both detected decreases in small cortical clusters and concomitant increases in extensive subcortical regions. Cerebellum normalization revealed more widespread cortical decreases but no subcortical increase. In all comparisons, the Yakushev method detected nearly identical patterns of very extensive cortical hypometabolism. Lastly, the meta-analyses demonstrated that global CBF and CMRglc values are decreased in PD. Based on the results, we conclude that PD most likely has widespread cortical hypometabolism, even at early disease stages. In contrast, extensive subcortical hypermetabolism is probably not a feature of PD.

OPSAID Initial Design and Testing Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurd, Steven A.; Stamp, Jason Edwin; Chavez, Adrian R.

2007-11-01

Process Control System (PCS) security is critical to our national security. Yet, there are a number of technological, economic, and educational impediments to PCS owners implementing effective security on their systems. OPSAID (Open PCS Security Architecture for Interoperable Design), a project sponsored by the US Department of Energy's Office of Electricity Delivery and Reliability, aims to address this issue through developing and testing an open source architecture for PCS security. Sandia National Laboratories, along with a team of PCS vendors and owners, have developed and tested this PCS security architecture. This report describes their progress to date.2 AcknowledgementsThe authors acknowledgemore » and thank their colleagues for their assistance with the OPSAID project.Sandia National Laboratories: Alex Berry, Charles Perine, Regis Cassidy, Bryan Richardson, Laurence PhillipsTeumim Technical, LLC: Dave TeumimIn addition, the authors are greatly indebted to the invaluable help of the members of the OPSAID Core Team. Their assistance has been critical to the success and industry acceptance of the OPSAID project.Schweitzer Engineering Laboratory: Rhett Smith, Ryan Bradetich, Dennis GammelTelTone: Ori Artman Entergy: Dave Norton, Leonard Chamberlin, Mark AllenThe authors would like to acknowledge that the work that produced the results presented in this paper was funded by the U.S. Department of Energy/Office of Electricity Delivery and Energy Reliability (DOE/OE) as part of the National SCADA Test Bed (NSTB) Program. Executive SummaryProcess control systems (PCS) are very important for critical infrastructure and manufacturing operations, yet cyber security technology in PCS is generally poor. The OPSAID (Open PCS (Process Control System) Security Architecture for Interoperable Design) program is intended to address these security shortcomings by accelerating the availability and deployment of comprehensive security technology for PCS, both for existing PCS and inherently secure PCS in the future. All activities are closely linked to industry outreach and advisory efforts.Generally speaking, the OPSAID project is focused on providing comprehensive security functionality to PCS that communicate using IP. This is done through creating an interoperable PCS security architecture and developing a reference implementation, which is tested extensively for performance and reliability.This report first provides background on the PCS security problem and OPSAID, followed by goals and objectives of the project. The report also includes an overview of the results, including the OPSAID architecture and testing activities, along with results from industry outreach activities. Conclusion and recommendation sections follow. Finally, a series of appendices provide more detailed information regarding architecture and testing activities.Summarizing the project results, the OPSAID architecture was defined, which includes modular security functionality and corresponding component modules. The reference implementation, which includes the collection of component modules, was tested extensively and proved to provide more than acceptable performance in a variety of test scenarios. The primary challenge in implementation and testing was correcting initial configuration errors.OPSAID industry outreach efforts were very successful. A small group of industry partners were extensively involved in both the design and testing of OPSAID. Conference presentations resulted in creating a larger group of potential industry partners.Based upon experience implementing and testing OPSAID, as well as through collecting industry feedback, the OPSAID project has done well and is well received. Recommendations for future work include further development of advanced functionality, refinement of interoperability guidance, additional laboratory and field testing, and industry outreach that includes PCS owner education. 4 5 --This page intentionally left blank --« less

Desktop Publishing: Probable Effects on University Extension.

ERIC Educational Resources Information Center

Misanchuk, Earl R.

Desktop publishing (DTP) could potentially become a powerful, relatively inexpensive tool for use in university extension activities. This paper describes and explains the characteristics of DTP and examines its effects on university extension. In addition, it outlines the kind of hardware, software, and skills needed and costs; describes new…

77 FR 54908 - Extension of the Public Review and Comment Period and Announcement of an Additional Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... DEPARTMENT OF ENERGY National Nuclear Security Administration Extension of the Public Review and... Disposition Supplemental Environmental Impact Statement AGENCY: National Nuclear Security Administration, U.S. Department of Energy. ACTION: Extension of the public review and comment period and announcement of an...

Defining and Developing Curricula in the Context of Cooperative Extension

ERIC Educational Resources Information Center

Smith, Martin H.; Worker, Steven M.; Meehan, Cheryl L.; Schmitt-McQuitty, Lynn; Ambrose, Andrea; Brian, Kelley; Schoenfelder, Emily

2017-01-01

Effective curricula are considered to be the cornerstone of successful programming in Extension. However, there is no universal operationalized definition of the term "curriculum" as it applies to Extension. Additionally, the development of curricula requires a systematic process that takes into account numerous factors. We provide an…

BitTorious volunteer: server-side extensions for centrally-managed volunteer storage in BitTorrent swarms.

PubMed

Lee, Preston V; Dinu, Valentin

2015-11-04

Our publication of the BitTorious portal [1] demonstrated the ability to create a privatized distributed data warehouse of sufficient magnitude for real-world bioinformatics studies using minimal changes to the standard BitTorrent tracker protocol. In this second phase, we release a new server-side specification to accept anonymous philantropic storage donations by the general public, wherein a small portion of each user's local disk may be used for archival of scientific data. We have implementated the server-side announcement and control portions of this BitTorrent extension into v3.0.0 of the BitTorious portal, upon which compatible clients may be built. Automated test cases for the BitTorious Volunteer extensions have been added to the portal's v3.0.0 release, supporting validation of the "peer affinity" concept and announcement protocol introduced by this specification. Additionally, a separate reference implementation of affinity calculation has been provided in C++ for informaticians wishing to integrate into libtorrent-based projects. The BitTorrent "affinity" extensions as provided in the BitTorious portal reference implementation allow data publishers to crowdsource the extreme storage prerequisites for research in "big data" fields. With sufficient awareness and adoption of BitTorious Volunteer-based clients by the general public, the BitTorious portal may be able to provide peta-scale storage resources to the scientific community at relatively insignificant financial cost.

Testing thin-skinned inversion of a prerift salt-bearing passive margin (Eastern Prebetic Zone, SE Iberia)

NASA Astrophysics Data System (ADS)

Escosa, Frederic O.; Roca, Eduard; Ferrer, Oriol

2018-04-01

Detailed geologic mapping combined with well and seismic data from the Eastern Prebetic Zone (SE Iberia) reveal extensional and contractional structures that permit characterization of passive margin development and its incorporation into a thin-skinned fold-and-thrust belt. The study area is represented by NW-directed, ENE-trending folds and thrusts faults locally disrupted by the NW-trending Matamoros Basin and the active Jumilla and La Rosa diapirs. These structures resulted from the thin-skinned inversion of the proximal part of the Eastern South Iberian passive margin containing prerift salt. Here, Upper Jurassic to Santonian thick-skinned extension controlled the accumulation of sediment over mobile prerift salt. This in turn defined the style of salt tectonics characterized by monoclinal drape folds, suprasalt extensional faults and diapirs. The structural and sedimentological analysis suggests that during extension, salt localizes strain thus decoupling sub- and suprasalt deformation. Thick-skinned extension controls suprasalt deformation as well as its location and distribution which changes over time. Salt also localizes strain during inversion. The preexisting salt structures, weaker than adjacent areas, preferentially absorb the contractional deformation. In addition, the stepped subsalt geometry that results from thick-skinned extension also controls the shortening propagation. Therefore, the degree of strain localization depends on the thickness of the suprasalt cover and on the dip of subsalt faults relative to the thin-skinned transport direction.

41 CFR 300-90.8 - What must we do to apply for a test program extension?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false What must we do to apply for a test program extension? 300-90.8 Section 300-90.8 Public Contracts and Property Management Federal Travel Regulation System GENERAL AGENCY REQUIREMENTS 90-TELEWORK TRAVEL EXPENSES TEST PROGRAMS...

Extensive intracranial calcification of pseudo-TORCH syndrome with features of Dandy–Walker malformation

PubMed Central

Patnaik, Ashis; Mishra, Sudhansu Sekhar; Das, Srikanta

2017-01-01

Pseudo-TORCH syndrome or congenital infection-like syndrome is a group of conditions which resemble congenital infections such as those caused by toxoplasmosis, rubella, cytomegalovirus (CMV), herpes (TORCH) group of organisms, clinico-radiologically, but serological tests are negative for the organisms. One of the variety shows features such as microcephaly, extensive intracranial calcification showing gross resemblance to congenital CMV infection, making its other name as microcephaly intracranial calcification syndrome (MICS). Dandy–Walker malformation (DWM), in addition to posterior fossa large cyst, cerebellar vermis hypoplasia, and hydrocephalus is often associated with agenesis of the corpus callosum and callosal lipomas, dysplasia of the brainstem, and cerebellar hypoplasia or dysgenesis. But radiological features of DWM with microcephaly and intracranial calcification are very unusual and have been rarely reported in the literature.[1] We report a case of infant showing clinical features suggestive of congenital CMV infection with negative serology and radiological imaging suggestive of DWM with extensive intracranial calcification. Pseudo-TORCH syndrome with radiological features of DWM is a congenital developmental abnormality. Inspite of hydrocephalus, it does not require cerebrospinal fluid (CSF) diversionary procedure due to lack of increased intracranial pressure. Conservative management for seizure disorder is the optimal therapy. PMID:28761539

Extensive intracranial calcification of pseudo-TORCH syndrome with features of Dandy-Walker malformation.

PubMed

Patnaik, Ashis; Mishra, Sudhansu Sekhar; Das, Srikanta

2017-01-01

Pseudo-TORCH syndrome or congenital infection-like syndrome is a group of conditions which resemble congenital infections such as those caused by toxoplasmosis, rubella, cytomegalovirus (CMV), herpes (TORCH) group of organisms, clinico-radiologically, but serological tests are negative for the organisms. One of the variety shows features such as microcephaly, extensive intracranial calcification showing gross resemblance to congenital CMV infection, making its other name as microcephaly intracranial calcification syndrome (MICS). Dandy-Walker malformation (DWM), in addition to posterior fossa large cyst, cerebellar vermis hypoplasia, and hydrocephalus is often associated with agenesis of the corpus callosum and callosal lipomas, dysplasia of the brainstem, and cerebellar hypoplasia or dysgenesis. But radiological features of DWM with microcephaly and intracranial calcification are very unusual and have been rarely reported in the literature.[1] We report a case of infant showing clinical features suggestive of congenital CMV infection with negative serology and radiological imaging suggestive of DWM with extensive intracranial calcification. Pseudo-TORCH syndrome with radiological features of DWM is a congenital developmental abnormality. Inspite of hydrocephalus, it does not require cerebrospinal fluid (CSF) diversionary procedure due to lack of increased intracranial pressure. Conservative management for seizure disorder is the optimal therapy.

A powerful and flexible approach to the analysis of RNA sequence count data

PubMed Central

Zhou, Yi-Hui; Xia, Kai; Wright, Fred A.

2011-01-01

Motivation: A number of penalization and shrinkage approaches have been proposed for the analysis of microarray gene expression data. Similar techniques are now routinely applied to RNA sequence transcriptional count data, although the value of such shrinkage has not been conclusively established. If penalization is desired, the explicit modeling of mean–variance relationships provides a flexible testing regimen that ‘borrows’ information across genes, while easily incorporating design effects and additional covariates. Results: We describe BBSeq, which incorporates two approaches: (i) a simple beta-binomial generalized linear model, which has not been extensively tested for RNA-Seq data and (ii) an extension of an expression mean–variance modeling approach to RNA-Seq data, involving modeling of the overdispersion as a function of the mean. Our approaches are flexible, allowing for general handling of discrete experimental factors and continuous covariates. We report comparisons with other alternate methods to handle RNA-Seq data. Although penalized methods have advantages for very small sample sizes, the beta-binomial generalized linear model, combined with simple outlier detection and testing approaches, appears to have favorable characteristics in power and flexibility. Availability: An R package containing examples and sample datasets is available at http://www.bios.unc.edu/research/genomic_software/BBSeq Contact: yzhou@bios.unc.edu; fwright@bios.unc.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:21810900

Adjusted scaling of FDG positron emission tomography images for statistical evaluation in patients with suspected Alzheimer's disease.

PubMed

Buchert, Ralph; Wilke, Florian; Chakrabarti, Bhismadev; Martin, Brigitte; Brenner, Winfried; Mester, Janos; Clausen, Malte

2005-10-01

Statistical parametric mapping (SPM) gained increasing acceptance for the voxel-based statistical evaluation of brain positron emission tomography (PET) with the glucose analog 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) in patients with suspected Alzheimer's disease (AD). To increase the sensitivity for detection of local changes, individual differences of total brain FDG uptake are usually compensated for by proportional scaling. However, in cases of extensive hypometabolic areas, proportional scaling overestimates scaled uptake. This may cause significant underestimation of the extent of hypometabolic areas by the statistical test. To detect this problem, the authors tested for hypermetabolism. In patients with no visual evidence of true focal hypermetabolism, significant clusters of hypermetabolism in the presence of extended hypometabolism were interpreted as false-positive findings, indicating relevant overestimation of scaled uptake. In this case, scaled uptake was reduced step by step until there were no more significant clusters of hypermetabolism. In 22 consecutive patients with suspected AD, proportional scaling resulted in relevant overestimation of scaled uptake in 9 patients. Scaled uptake had to be reduced by 11.1% +/- 5.3% in these cases to eliminate the artifacts. Adjusted scaling resulted in extension of existing and appearance of new clusters of hypometabolism. Total volume of the additional voxels with significant hypometabolism depended linearly on the extent of the additional scaling and was 202 +/- 118 mL on average. Adjusted scaling helps to identify characteristic metabolic patterns in patients with suspected AD. It is expected to increase specificity of FDGPET in this group of patients.

Long-period noise source inversion in a 3-D heterogeneous Earth

NASA Astrophysics Data System (ADS)

Sager, K.; Ermert, L. A.; Afanasiev, M.; Boehm, C.; Fichtner, A.

2017-12-01

We have implemented a new method for ambient noise source inversion that fully honors finite-frequency wave propagation and 3-D heterogeneous Earth structure.Here, we present results of its first application to the Earth's long-period background signal, the hum, in a period band of around 120 - 300 s. In addition to being a computationally convenient test case, the hum is also the topic of ongoing research in its own right, because different physical mechanisms have been proposed for its excitation. The broad patterns of this model for South and North hemisphere winter are qualitatively consistent with previous long-term studies of the hum sources; however, thanks to methodological improvements, the iterative refinement, and the use of a comparatively extensive dataset, we retrieve a more detailed model in certain locations. In particular, our results support findings that the dominant hum sources are focused along coasts and shelf areas, particularly in the North hemisphere winter, with a possible though not well-constrained contribution of pelagic sources. Additionally, our findings indicate that hum source locations in the ocean, tentatively linked to locally high bathymetry, are important contributors particularly during South hemisphere winter. These results, in conjunction with synthetic recovery tests and observed cross-correlation waveforms, suggest that hum sources are rather narrowly concentrated in space, with length scales on the order of few hundred kilometers. Future work includes the extension of the model to spring and fall season and to shorter periods, as well as its use in full-waveform ambient noise inversion for 3-D Earth structure.

FGD Additives to Segregate and Sequester Mercury in Solid Byproducts - Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Searcy, K; Bltyhe, G M; Steen, W A

2012-02-28

Many mercury control strategies for U.S. coal-fired power generating plants involve co-benefit capture of oxidized mercury from flue gases treated by wet flue gas desulfurization (FGD) systems. For these processes to be effective at overall mercury control, the captured mercury must not be re-emitted to the atmosphere or into surface or ground water. The project sought to identify scrubber additives and FGD operating conditions under which mercury re-emissions would decrease and mercury would remain in the liquor and be blown down from the system in the chloride purge stream. After exiting the FGD system, mercury would react with precipitating agentsmore » to form stable solid byproducts and would be removed in a dewatering step. The FGD gypsum solids, free of most of the mercury, could then be disposed or processed for reuse as wallboard or in other beneficial reuse. The project comprised extensive bench-scale FGD scrubber tests in Phases I and II. During Phase II, the approaches developed at the bench scale were tested at the pilot scale. Laboratory wastewater treatment tests measured the performance of precipitating agents in removing mercury from the chloride purge stream. Finally, the economic viability of the approaches tested was evaluated.« less

Impact of sodium chloride on wheat flour dough for yeast-leavened products. I. Rheological attributes.

PubMed

Beck, Margit; Jekle, Mario; Becker, Thomas

2012-02-01

The rheological properties of wheat dough for yeast-leavened products were tested at different levels of sodium chloride (NaCl) addition ranging from 0 to 40 g NaCl kg⁻¹ wheat flour. Rheological tests carried out to make this evaluation included (1) empirical rheological methods of the Farinograph, load extension and a dough stickiness test and (2) fundamental rheological methods of creep recovery and dynamic rheometry. Modifications to the gluten matrix microstructure by NaCl were examined by confocal laser-scanning microscopy. Highly significant (P⩽0.001) differences due to NaCl addition could be determined in particular by the stickiness test as well as by examination of the creep test with the Burger model. Rheological changes measured in the creep test probably depend on protein charge shielding due to NaCl interaction, resulting in an improvement in gluten network formation. An increase in dough stickiness was measured when using NaCl. The present result for stickiness is contrary to the common subjective results. Therefore the theory proposed here for increased stickiness suggests that it is based on more non-protein-bound water in the dough system due to NaCl interaction and thus more viscous dough behaviour, which leads to higher stickiness as measured with the stickiness test. This may also suggest that the objectively measured 'stickiness' in this case does not properly indicate the subjectively measured stickiness it was designed to represent. Copyright © 2011 Society of Chemical Industry.

Hybrid Teaching in Extension: Learning at the Crossroads

ERIC Educational Resources Information Center

Hino, Jeff; Kahn, Cub

2016-01-01

Extension clients' learning preferences are changing, with many increasingly going online for educational content. In response, Oregon State University Extension pilot tested a training program for Extension educators to explore hybrid teaching--a methodology that could provide more flexible access to a wider audience. Hybrid teaching offers a…

Adjuvant Brachytherapy Removes Survival Disadvantage of Local Disease Extension in Stage IIIC Endometrial Cancer: A SEER Registry Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rossi, Peter J.; Jani, Ashesh B.; Horowitz, Ira R.

2008-01-01

Purpose: To assess the role of radiotherapy (RT) in women with Stage IIIC endometrial cancer. Methods and Materials: The 17-registry Survival, Epidemiology, and End Results (SEER) database was searched for patients with lymph node-positive non-Stage IV epithelial endometrial cancer diagnosed and treated between 1988 and 1998. Two subgroups were identified: those with organ-confined Stage IIIC endometrial cancer and those with Stage IIIC endometrial cancer with direct extension of the primary tumor. RT was coded as external beam RT (EBRT) or brachytherapy (BT). Observed survival (OS) was reported with a minimum of 5 years of follow-up; the survival curves were comparedmore » using the log-rank test. Results: The therapy data revealed 611 women with Stage IIIC endometrial cancer during this period. Of these women, 51% were treated with adjuvant EBRT, 21% with EBRT and BT, and 28% with no additional RT (NAT). Of the 611 patients, 293 had organ-confined Stage IIIC endometrial cancer and 318 patients had Stage IIIC endometrial cancer with direct extension of the primary tumor. The 5-year OS rate for all patients was 40% with NAT, 56% after EBRT, and 64% after EBRT/BT. Adjuvant RT improved survival compared with NAT (p <0.001). In patients with organ-confined Stage IIIC endometrial cancer, the 5-year OS rate was 50% for NAT, 64% for EBRT, and 67% for EBRT/BT. Again, adjuvant RT contributed to improved survival compared with NAT (p = 0.02). In patients with Stage IIIC endometrial cancer and direct tumor extension, the 5-year OS rate was 34% for NAT, 47% for EBRT, and 63% for EBRT/BT. RT improved OS compared with NAT (p <0.001). Also, in this high-risk subgroup, adding BT to EBRT was superior to EBRT alone (p = 0.002). Conclusion: Women with Stage IIIC endometrial cancer receiving adjuvant EBRT and EBRT/BT had improved OS compared with patients receiving NAT. When direct extension of the primary tumor was present, the addition of BT to EBRT was even more beneficial.« less

Adjuvant brachytherapy removes survival disadvantage of local disease extension in stage IIIC endometrial cancer: a SEER registry analysis.

PubMed

Rossi, Peter J; Jani, Ashesh B; Horowitz, Ira R; Johnstone, Peter A S

2008-01-01

To assess the role of radiotherapy (RT) in women with Stage IIIC endometrial cancer. The 17-registry Survival, Epidemiology, and End Results (SEER) database was searched for patients with lymph node-positive non-Stage IV epithelial endometrial cancer diagnosed and treated between 1988 and 1998. Two subgroups were identified: those with organ-confined Stage IIIC endometrial cancer and those with Stage IIIC endometrial cancer with direct extension of the primary tumor. RT was coded as external beam RT (EBRT) or brachytherapy (BT). Observed survival (OS) was reported with a minimum of 5 years of follow-up; the survival curves were compared using the log-rank test. The therapy data revealed 611 women with Stage IIIC endometrial cancer during this period. Of these women, 51% were treated with adjuvant EBRT, 21% with EBRT and BT, and 28% with no additional RT (NAT). Of the 611 patients, 293 had organ-confined Stage IIIC endometrial cancer and 318 patients had Stage IIIC endometrial cancer with direct extension of the primary tumor. The 5-year OS rate for all patients was 40% with NAT, 56% after EBRT, and 64% after EBRT/BT. Adjuvant RT improved survival compared with NAT (p <0.001). In patients with organ-confined Stage IIIC endometrial cancer, the 5-year OS rate was 50% for NAT, 64% for EBRT, and 67% for EBRT/BT. Again, adjuvant RT contributed to improved survival compared with NAT (p = 0.02). In patients with Stage IIIC endometrial cancer and direct tumor extension, the 5-year OS rate was 34% for NAT, 47% for EBRT, and 63% for EBRT/BT. RT improved OS compared with NAT (p <0.001). Also, in this high-risk subgroup, adding BT to EBRT was superior to EBRT alone (p = 0.002). Women with Stage IIIC endometrial cancer receiving adjuvant EBRT and EBRT/BT had improved OS compared with patients receiving NAT. When direct extension of the primary tumor was present, the addition of BT to EBRT was even more beneficial.

Tests of local Lorentz invariance violation of gravity in the standard model extension with pulsars.

PubMed

Shao, Lijing

2014-03-21

The standard model extension is an effective field theory introducing all possible Lorentz-violating (LV) operators to the standard model and general relativity (GR). In the pure-gravity sector of minimal standard model extension, nine coefficients describe dominant observable deviations from GR. We systematically implemented 27 tests from 13 pulsar systems to tightly constrain eight linear combinations of these coefficients with extensive Monte Carlo simulations. It constitutes the first detailed and systematic test of the pure-gravity sector of minimal standard model extension with the state-of-the-art pulsar observations. No deviation from GR was detected. The limits of LV coefficients are expressed in the canonical Sun-centered celestial-equatorial frame for the convenience of further studies. They are all improved by significant factors of tens to hundreds with existing ones. As a consequence, Einstein's equivalence principle is verified substantially further by pulsar experiments in terms of local Lorentz invariance in gravity.

Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases

PubMed Central

Lu, Stephen M.; Lu, Wuyuan; Qasim, M. A.; Anderson, Stephen; Apostol, Izydor; Ardelt, Wojciech; Bigler, Theresa; Chiang, Yi Wen; Cook, James; James, Michael N. G.; Kato, Ikunoshin; Kelly, Clyde; Kohr, William; Komiyama, Tomoko; Lin, Tiao-Yin; Ogawa, Michio; Otlewski, Jacek; Park, Soon-Jae; Qasim, Sabiha; Ranjbar, Michael; Tashiro, Misao; Warne, Nicholas; Whatley, Harry; Wieczorek, Anna; Wieczorek, Maciej; Wilusz, Tadeusz; Wynn, Richard; Zhang, Wenlei; Laskowski, Michael

2001-01-01

An additivity-based sequence to reactivity algorithm for the interaction of members of the Kazal family of protein inhibitors with six selected serine proteinases is described. Ten consensus variable contact positions in the inhibitor were identified, and the 19 possible variants at each of these positions were expressed. The free energies of interaction of these variants and the wild type were measured. For an additive system, this data set allows for the calculation of all possible sequences, subject to some restrictions. The algorithm was extensively tested. It is exceptionally fast so that all possible sequences can be predicted. The strongest, the most specific possible, and the least specific inhibitors were designed, and an evolutionary problem was solved. PMID:11171964

Interaction Models for Functional Regression.

PubMed

Usset, Joseph; Staicu, Ana-Maria; Maity, Arnab

2016-02-01

A functional regression model with a scalar response and multiple functional predictors is proposed that accommodates two-way interactions in addition to their main effects. The proposed estimation procedure models the main effects using penalized regression splines, and the interaction effect by a tensor product basis. Extensions to generalized linear models and data observed on sparse grids or with measurement error are presented. A hypothesis testing procedure for the functional interaction effect is described. The proposed method can be easily implemented through existing software. Numerical studies show that fitting an additive model in the presence of interaction leads to both poor estimation performance and lost prediction power, while fitting an interaction model where there is in fact no interaction leads to negligible losses. The methodology is illustrated on the AneuRisk65 study data.

Leveraging simulation to evaluate system performance in presence of fixed pattern noise

NASA Astrophysics Data System (ADS)

Teaney, Brian P.

2017-05-01

The development of image simulation techniques which map the effects of a notional, modeled sensor system onto an existing image can be used to evaluate the image quality of camera systems prior to the development of prototype systems. In addition, image simulation or `virtual prototyping' can be utilized to reduce the time and expense associated with conducting extensive field trials. In this paper we examine the development of a perception study designed to assess the performance of the NVESD imager performance metrics as a function of fixed pattern noise. This paper discusses the development of the model theory and the implementation and execution of the perception study. In addition, other applications of the image simulation component including the evaluation of limiting resolution and other test targets is provided.

The heavy top quark and supersymmetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hall, L.J.

1997-01-01

Three aspects of supersymmetric theories are discussed: electroweak symmetry breaking, the issues of flavor, and gauge unification. The heavy top quark plays an important, sometimes dominant, role in each case. Additional symmetries lead to extensions of the Standard Model which can provide an understanding for many of the outstanding problems of particle physics. A broken supersymmetric extension of spacetime allows electroweak symmetry breaking to follow from the dynamics of the heavy top quark; an extension of isospin provides a constrained framework for understanding the pattern of quark and lepton masses; and a grand unified extension of the Standard Model gaugemore » group provides an elegant understanding of the gauge quantum numbers of the components of a generation. Experimental signatures for each of these additional symmetries are discussed.« less

On Extending the Probationary Period

ERIC Educational Resources Information Center

Andrews, James G.

2009-01-01

A number of U.S. institutions of higher education are considering multiyear extensions of the widely accepted seven-year maximum probationary period for all tenure-track faculty. Such a substantial extension is to be distinguished from, and exists in addition to, the ad hoc short-term extensions that many institutions may now grant to individual…

The Role of Extension Specialists in Helping Entrepreneurs Develop Successful Food-Based Businesses.

ERIC Educational Resources Information Center

Holcomb, Rodney; Muske, Glenn

2000-01-01

Three areas in which extension specialists can assist food industry entrepreneurs include (1) awareness of the components of a business plan, (2) pro forma financial analysis, and (3) legal issues affecting the food industry. In addition to specialized expertise, extension professionals can help with making contacts, objectively review business…

76 FR 44305 - Honey From Argentina: Extension of Time Limit for Preliminary Results of Antidumping Duty New...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

...: Extension of Time Limit for Preliminary Results of Antidumping Duty New Shipper Review AGENCY: Import... results of this review is July 24, 2011. Extension of Time Limits for Preliminary Results of Review... time to complete the preliminary results. Specifically, the Department requires additional time to...

78 FR 53138 - Notice of Extension of Public Comment Period on the Draft IRIS Carcinogenicity Assessment for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

... Extension of Public Comment Period on the Draft IRIS Carcinogenicity Assessment for Ethylene Oxide and Addition of Ethylene Oxide to October IRIS Bimonthly Meeting Agenda AGENCY: Environmental Protection Agency... Ethylene Oxide to October IRIS Bimonthly Meeting Agenda. SUMMARY: EPA is announcing an extension of the...

Relationship between performance test and body composition/physical strength characteristic in sprint canoe and kayak paddlers

PubMed Central

Hamano, Saki; Ochi, Eisuke; Tsuchiya, Yosuke; Muramatsu, Erina; Suzukawa, Kazuhiro; Igawa, Shoji

2015-01-01

Objective Canoe sprint is divided into canoe and kayak. The difference between the two competitions is in physical performance. The aim of the present study was to compare and investigate the relationship between physical characteristics and fitness between the two canoe sprint competitors. Methods Subjects were 11 canoe paddlers (C) and 12 kayak paddlers (K). They underwent anthropometric characteristics, body composition and fitness tests, and 120 s all-out tests using a canoe and kayak ergometer. The unpaired t-test was used to test for significant differences between disciplines, while Pearson’s correlation coefficient was used to examine the association between each measurement item and the performance test. Results The age, height, body mass, body mass index, and total body fat were, C: 20.6±0.9 yr, 172.8±5.2 cm, 70.8±7.8 kg, 23.7±1.9, 14.4%±3.5%; and K: 19.7±1.2 yr, 172.8±5.3 cm, 69.5±7.8 kg, 23.2±2.1, 12.1%±3.6%, respectively. No significant differences were seen in any of the items for physical characteristics or fitness between C and K. A correlation analysis of performance tests and each measurement item revealed a positive correlation with low-speed isokinetic knee extension and flexion strength for C only (extension: r=0.761; flexion: r=0.784; P<0.01). In addition, performance tests were positively correlated with the circumference of arm (upper arm: r=0.876; forearm: r=0.820; P<0.01) and lower limb (thigh: r=0.781; calf: r=0.753; P<0.01) in C and with height (r=0.549, P<0.05), arm span (r=0.639, P<0.05), and leg length (r=0.621, P<0.01) in K. Conclusion We suggest that the factors correlating with the performance test differ depending on the competitions. PMID:26150737

Alkali deposits found in biomass power plants: A preliminary investigation of their extent and nature. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miles, T.R.; Miles, T.R. Jr.; Baxter, L.L.

1995-04-15

Alkali in the ash of annual crop biomass fuels creates serious fouling and slagging in conventional boilers. Even with the use of sorbents and other additives, power plants can only fire limited amounts of these fuels in combination with wood. The National Renewable Energy Laboratory (NREL), US Department of Energy, and the biomass power industry carried out eight full-scale firing tests and several laboratory experiments to study the nature and occurrence of deposits with the goal of increasing the quantities of these biofuels that can be used. This report describes the results of the laboratory and power plant tests thatmore » included: tracking and analyzing fuels and deposits by various methods; recording operating conditions; and extensive laboratory testing. The paper describes the occurrence of deposits, fuel and deposit analyses, boiler design and operation, fouling and slagging indicators, and recommendations. 37 refs., 41 figs., 17 tabs.« less

Teratology studies in the rat.

PubMed

Leroy, Mariline; Allais, Linda

2013-01-01

The rat is the rodent species of choice for the regulatory safety testing of xenobiotics, such as medicinal products, food additives, and other chemicals. Many decades of experience and extensive data have accumulated for both general and developmental toxicology investigations in this species. The high fertility and large litter size of the rat are advantages for teratogenicity testing. The study designs are well defined in the regulatory guidelines and are relatively standardized between testing laboratories across the world. Teratology studies address maternal- and embryo-toxicity following exposure during the period of organogenesis. This chapter describes the design and conduct of a teratology study in the rat in compliance with the regulatory guidelines. The procedures for the handling and housing of the pregnant animals, the caesarean examinations and the sampling of fetuses for morphological examinations are described. The utility and design of preliminary studies and the inclusion of satellite animals in the main study for toxicokinetic sampling are discussed.

Evidence of automatic processing in sequence learning using process-dissociation

PubMed Central

Mong, Heather M.; McCabe, David P.; Clegg, Benjamin A.

2012-01-01

This paper proposes a way to apply process-dissociation to sequence learning in addition and extension to the approach used by Destrebecqz and Cleeremans (2001). Participants were trained on two sequences separated from each other by a short break. Following training, participants self-reported their knowledge of the sequences. A recognition test was then performed which required discrimination of two trained sequences, either under the instructions to call any sequence encountered in the experiment “old” (the inclusion condition), or only sequence fragments from one half of the experiment “old” (the exclusion condition). The recognition test elicited automatic and controlled process estimates using the process dissociation procedure, and suggested both processes were involved. Examining the underlying processes supporting performance may provide more information on the fundamental aspects of the implicit and explicit constructs than has been attainable through awareness testing. PMID:22679465

Mobile HIV screening in Cape Town, South Africa: clinical impact, cost and cost-effectiveness.

PubMed

Bassett, Ingrid V; Govindasamy, Darshini; Erlwanger, Alison S; Hyle, Emily P; Kranzer, Katharina; van Schaik, Nienke; Noubary, Farzad; Paltiel, A David; Wood, Robin; Walensky, Rochelle P; Losina, Elena; Bekker, Linda-Gail; Freedberg, Kenneth A

2014-01-01

Mobile HIV screening may facilitate early HIV diagnosis. Our objective was to examine the cost-effectiveness of adding a mobile screening unit to current medical facility-based HIV testing in Cape Town, South Africa. We used the Cost Effectiveness of Preventing AIDS Complications International (CEPAC-I) computer simulation model to evaluate two HIV screening strategies in Cape Town: 1) medical facility-based testing (the current standard of care) and 2) addition of a mobile HIV-testing unit intervention in the same community. Baseline input parameters were derived from a Cape Town-based mobile unit that tested 18,870 individuals over 2 years: prevalence of previously undiagnosed HIV (6.6%), mean CD4 count at diagnosis (males 423/µL, females 516/µL), CD4 count-dependent linkage to care rates (males 31%-58%, females 49%-58%), mobile unit intervention cost (includes acquisition, operation and HIV test costs, $29.30 per negative result and $31.30 per positive result). We conducted extensive sensitivity analyses to evaluate input uncertainty. Model outcomes included site of HIV diagnosis, life expectancy, medical costs, and the incremental cost-effectiveness ratio (ICER) of the intervention compared to medical facility-based testing. We considered the intervention to be "very cost-effective" when the ICER was less than South Africa's annual per capita Gross Domestic Product (GDP) ($8,200 in 2012). We projected that, with medical facility-based testing, the discounted (undiscounted) HIV-infected population life expectancy was 132.2 (197.7) months; this increased to 140.7 (211.7) months with the addition of the mobile unit. The ICER for the mobile unit was $2,400/year of life saved (YLS). Results were most sensitive to the previously undiagnosed HIV prevalence, linkage to care rates, and frequency of HIV testing at medical facilities. The addition of mobile HIV screening to current testing programs can improve survival and be very cost-effective in South Africa and other resource-limited settings, and should be a priority.

First Generation Least Expensive Approach to Fission (FiGLEAF) Testing Results

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Houts, Mike; Pedersen, Kevin; Godfroy, Tom; Dickens, Ricky; Poston, David; Reid, Bob; Salvail. Pat; Ring, Peter; Schmidt, George R. (Technical Monitor)

2000-01-01

Successful development of space fission systems will require an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. Testing can be divided into two categories, non-nuclear tests and nuclear tests. Full power nuclear tests of space fission systems are expensive, time consuming, and of limited use, even in the best of programmatic environments. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system performance and lifetime can be attained through a series of non-nuclear tests. Non-nuclear tests are affordable and timely, and the cause of component and system failures can be quickly and accurately identified. MSFC is leading a Safe Affordable Fission Engine (SAFE) test series whose ultimate goal is the demonstration of a 300 kW flight configuration system using non-nuclear testing. This test series is carried out in collaboration with other NASA centers, other government agencies, industry, and universities. The paper describes the SAFE test series, which includes test article descriptions, test results and conclusions, and future test plans.

Experimental measurement of flexion-extension movement in normal and corpse prosthetic elbow joint.

PubMed

TarniŢă, Daniela; TarniŢă, DănuŢ Nicolae

2016-01-01

This paper presents a comparative experimental study of flexion-extension movement in healthy elbow and in the prosthetic elbow joint fixed on an original experimental bench. Measurements were carried out in order to validate the functional morphology and a new elbow prosthesis type ball head. The three-dimensional (3D) model and the physical prototype of our experimental bench used to test elbow endoprosthesis at flexion-extension and pronation-supination movements is presented. The measurements were carried out on a group of nine healthy subjects and on the prosthetic corpse elbow, the experimental data being obtained for flexion-extension movement cycles. Experimental data for the two different flexion-extension tests for the nine subjects and for the corpse prosthetic elbow were acquired using SimiMotion video system. Experimental data were processed statistically. The corresponding graphs were obtained for all subjects in the experimental group, and for corpse prosthetic elbow for both flexion-extension tests. The statistical analysis has proved that the flexion angles of healthy elbows were significantly close to the values measured at the prosthetic elbow fixed on the experimental bench. The studied elbow prosthesis manages to re-establish the mobility for the elbow joint as close to the normal one.

Optimal sagittal motion axis for trunk extension and flexion tests in chronic low back trouble.

PubMed

Rantanen, P; Nykvist, F

2000-11-01

To find the optimal height for sagittal motion axis for trunk strength test in chronic low back trouble. Cross-sectional study. The strength of trunk muscles of low back pain patients is decreased. The measured strength depends on the height of the sagittal motion axis but the differences between patients and controls are not known. 114 (67 female) patients with chronic low back trouble are classified according to Quebec Task Force, 50 (31 female) patients with rheumatic disorder, but without low back trouble, and 33 (22 female) healthy controls, no appreciable physical differences but clear differences in Oswestry score. Isometric trunk extension-flexion test with different heights for the pelvic fulcrum. Force decreased in extension, increased in flexion, and torque increased both in flexion and extension in every group (P<0.001) as the fulcrum was moved caudally. The male controls were stronger than patients with low back trouble (P<0.01). The female controls were stronger only if the fulcrum was set at the hip joint level (P<0.05). There were no differences between patients with rheumatic disorder and low back trouble, except in extension if the fulcrum was at the hip joint level (P<0.02). The rotation axis in trunk extension-flexion strength test should be set at the level of the hip joint. Trunk muscle weakness is a common sign of different rheumatic disorders. Proper setting of sagittal motion axis and concomitant measurement of trunk and hip extensor or flexor muscles increases the specificity of the strength test for low back trouble.

Influence of hamstring muscles extensibility on spinal curvatures and pelvic tilt in highly trained cyclists.

PubMed

Muyor, José M; Alacid, Fernando; López-Miñarro, Pedro A

2011-09-01

The purpose of this study was to determine the influence of hamstring muscles extensibility in standing, maximal trunk flexion with knees extended and on the bicycle in lower handlebar-hands position of highly trained cyclists. Ninety-six cyclists were recruited for the study (mean ± SD, age: 30.36 ± 5.98 years). Sagittal spinal curvatures and pelvic tilt were measured in the standing position, maximal trunk flexion with knees extended (sit-and-reach test) and while sitting on a bicycle in lower handlebar-hand position using a Spinal Mouse system. Hamstring muscles extensibility was determined in both legs by passive straight leg raise test (PSLR). The sample was divided into three groups according to PSLR angle: (1) reduced extensibility (PSLR < 80º; n = 30), (2) moderate hamstring extensibility group (PSLR = 80º - 90º; n = 35), and (3) high hamstring extensibility (PSLR = > 90º; n = 31). ANOVA analysis showed significant differences among groups for thoracic (p < 0.001) and pelvic tilt (p < 0.001) angles in the sit-and-reach test. No differences were found between groups for standing and on the bicycle position. Post hoc analysis showed significant differences in all pairwise comparisons for thoracic angle (p < 0.01) and pelvic angle (p < 0.001) in the sit-and-reach test. No differences were found in lumbar angle in any posture. In conclusion, the hamstring muscles extensibility influence the thoracic and pelvic postures when maximal trunk flexion with knees extended is performed, but not when cyclists are seated on their bicycles.

Influence of Hamstring Muscles Extensibility on Spinal Curvatures and Pelvic Tilt in Highly Trained Cyclists

PubMed Central

Muyor, José M.; Alacid, Fernando; López-Miñarro, Pedro A.

2011-01-01

The purpose of this study was to determine the influence of hamstring muscles extensibility in standing, maximal trunk flexion with knees extended and on the bicycle in lower handlebar-hands position of highly trained cyclists. Ninety-six cyclists were recruited for the study (mean ± SD, age: 30.36 ± 5.98 years). Sagittal spinal curvatures and pelvic tilt were measured in the standing position, maximal trunk flexion with knees extended (sit-and-reach test) and while sitting on a bicycle in lower handlebar-hand position using a Spinal Mouse system. Hamstring muscles extensibility was determined in both legs by passive straight leg raise test (PSLR). The sample was divided into three groups according to PSLR angle: (1) reduced extensibility (PSLR < 80º; n = 30), (2) moderate hamstring extensibility group (PSLR = 80º – 90º; n = 35), and (3) high hamstring extensibility (PSLR = > 90º; n = 31). ANOVA analysis showed significant differences among groups for thoracic (p < 0.001) and pelvic tilt (p < 0.001) angles in the sit-and-reach test. No differences were found between groups for standing and on the bicycle position. Post hoc analysis showed significant differences in all pairwise comparisons for thoracic angle (p < 0.01) and pelvic angle (p < 0.001) in the sit-and-reach test. No differences were found in lumbar angle in any posture. In conclusion, the hamstring muscles extensibility influence the thoracic and pelvic postures when maximal trunk flexion with knees extended is performed, but not when cyclists are seated on their bicycles PMID:23486997

Biomechanical analysis of anterior versus posterior instrumentation following a thoracolumbar corpectomy: Laboratory investigation.

PubMed

Viljoen, Stephanus V; DeVries Watson, Nicole A; Grosland, Nicole M; Torner, James; Dalm, Brian; Hitchon, Patrick W

2014-10-01

The objective of this study was to evaluate the biomechanical properties of lateral instrumentation compared with short- and long-segment pedicle screw constructs following an L-1 corpectomy and reconstruction with an expandable cage. Eight human cadaveric T10-L4 spines underwent an L-1 corpectomy followed by placement of an expandable cage. The spines then underwent placement of lateral instrumentation consisting of 4 monoaxial screws and 2 rods with 2 cross-connectors, short-segment pedicle screw fixation involving 1 level above and below the corpectomy, and long-segment pedicle screw fixation (2 levels above and below). The order of instrumentation was randomized in the 8 specimens. Testing was conducted for each fixation technique. The spines were tested with a pure moment of 6 Nm in all 6 degrees of freedom (flexion, extension, right and left lateral bending, and right and left axial rotation). In flexion, extension, and left/right lateral bending, posterior long-segment instrumentation had significantly less motion compared with the intact state. Additionally, posterior long-segment instrumentation was significantly more rigid than short-segment and lateral instrumentation in flexion, extension, and left/right lateral bending. In axial rotation, the posterior long-segment construct as well as lateral instrumentation were not significantly more rigid than the intact state. The posterior long-segment construct was the most rigid in all 6 degrees of freedom. In the setting of highly unstable fractures requiring anterior reconstruction, and involving all 3 columns, long-segment posterior pedicle screw constructs are the most rigid.

Application of damage tolerance methodology in certification of the Piaggio P-180 Avanti

NASA Technical Reports Server (NTRS)

Johnson, Jerry

1992-01-01

The Piaggio P-180 Avanti, a twin pusher-prop engine nine-passenger business aircraft was certified in 1990, to the requirements of FAR Part 23 and Associated Special Conditions for Composite Structure. Certification included the application of a damage tolerant methodology to the design of the composite forward wing and empennage (vertical fin, horizontal stabilizer, tailcone, and rudder) structure. This methodology included an extensive analytical evaluation coupled with sub-component and full-scale testing of the structure. The work from the Damage Tolerance Analysis Assessment was incorporated into the full-scale testing. Damage representing hazards such as dropped tools, ground equipment, handling, and runway debris, was applied to the test articles. Additional substantiation included allowing manufacturing discrepancies to exist unrepaired on the full-scale articles and simulated bondline failures in critical elements. The importance of full-scale testing in the critical environmental conditions and the application of critical damage are addressed. The implication of damage tolerance on static and fatigue testing is discussed. Good correlation between finite element solutions and experimental test data was observed.

Genetic Homologies Among Streptomyces violaceoruber Strains

PubMed Central

Monson, A. M.; Bradley, S. G.; Enquist, L. W.; Cruces, Griselda

1969-01-01

Most of the genetic studies on streptomycetes have been done with cultures erroneously designated as Streptomyces coelicolor. To determine whether these cultures are genetically homologous with the S. violaceoruber nominifer, their deoxyribonucleic acids (DNA) were analyzed, and selected pairs of mutants were crossed. The four cultures used in genetic studies, and called S. coelicolor in the literature, were found to constitute a genospecies, based upon DNA hybridization and recombination tests. In addition, DNA from Actinopycnidium caeruleum formed extensive duplexes with S. violaceoruber DNA. S. violaceoruber cultures and A. caeruleum were distinctly different from the S. coelicolor nominifer. PMID:5370275

VizieR Online Data Catalog: New Kepler planetary candidates (Ofir+, 2013)

NASA Astrophysics Data System (ADS)

Ofir, A.; Dreizler, S.

2013-10-01

We present first results of our efforts to re-analyze the Kepler photometric dataset, searching for planetary transits using an alternative processing pipeline to the one used by the Kepler mission The SARS pipeline was tried and tested extensively by processing all available CoRoT mission data. For this first paper of the series we used this pipeline to search for (additional) planetary transits only in a small subset of stars - the Kepler objects of interest (KOIs), which are already known to include at least one promising planet candidate. (2 data files).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendl, Christian B.; Spohn, Herbert

The nonequilibrium dynamics of anharmonic chains is studied by imposing an initial domain-wall state, in which the two half lattices are prepared in equilibrium with distinct parameters. Here, we analyse the Riemann problem for the corresponding Euler equations and, in specific cases, compare with molecular dynamics. Additionally, the fluctuations of time-integrated currents are investigated. In analogy with the KPZ equation, their typical fluctuations should be of size t 1/3 and have a Tracy–Widom GUE distributed amplitude. The proper extension to anharmonic chains is explained and tested through molecular dynamics. Our results are calibrated against the stochastic LeRoux lattice gas.

A relational extension of the notion of motifs: application to the common 3D protein substructures searching problem.

PubMed

Pisanti, Nadia; Soldano, Henry; Carpentier, Mathilde; Pothier, Joel

2009-12-01

The geometrical configurations of atoms in protein structures can be viewed as approximate relations among them. Then, finding similar common substructures within a set of protein structures belongs to a new class of problems that generalizes that of finding repeated motifs. The novelty lies in the addition of constraints on the motifs in terms of relations that must hold between pairs of positions of the motifs. We will hence denote them as relational motifs. For this class of problems, we present an algorithm that is a suitable extension of the KMR paradigm and, in particular, of the KMRC as it uses a degenerate alphabet. Our algorithm contains several improvements that become especially useful when-as it is required for relational motifs-the inference is made by partially overlapping shorter motifs, rather than concatenating them. The efficiency, correctness and completeness of the algorithm is ensured by several non-trivial properties that are proven in this paper. The algorithm has been applied in the important field of protein common 3D substructure searching. The methods implemented have been tested on several examples of protein families such as serine proteases, globins and cytochromes P450 additionally. The detected motifs have been compared to those found by multiple structural alignments methods.

Peripheral Nerve Repair in Rats Using Composite Hydrogel-Filled Aligned Nanofiber Conduits with Incorporated Nerve Growth Factor

PubMed Central

Jin, Jenny; Limburg, Sonja; Joshi, Sunil K.; Landman, Rebeccah; Park, Michelle; Zhang, Qia; Kim, Hubert T.

2013-01-01

Repair of peripheral nerve defects with current synthetic, tubular nerve conduits generally shows inferior recovery when compared with using nerve autografts, the current gold standard. We tested the ability of composite collagen and hyaluronan hydrogels, with and without the nerve growth factor (NGF), to stimulate neurite extension on a promising aligned, nanofiber poly-L-lactide-co-caprolactone (PLCL) scaffold. In vitro, the hydrogels significantly increased neurite extension from dorsal root ganglia explants. Consistent with these results, the addition of hydrogels as luminal fillers within aligned, nanofiber tubular PLCL conduits led to improved sensory function compared to autograft repair in a critical-size defect in the sciatic nerve in a rat model. Sensory recovery was assessed 3 and 12 weeks after repair using a withdrawal assay from thermal stimulation. The addition of hydrogel did not enhance recovery of motor function in the rat model. The NGF led to dose-dependent improvements in neurite out-growth in vitro, but did not have a significant effect in vivo. In summary, composite collagen/hyaluronan hydrogels enhanced sensory neurite outgrowth in vitro and sensory recovery in vivo. The use of such hydrogels as luminal fillers for tubular nerve conduits may therefore be useful in assisting restoration of protective sensation following peripheral nerve injury. PMID:23659607

Impact of imaging measurements on response assessment in glioblastoma clinical trials

PubMed Central

Reardon, David A.; Ballman, Karla V.; Buckner, Jan C.; Chang, Susan M.; Ellingson, Benjamin M.

2014-01-01

We provide historical and scientific guidance on imaging response assessment for incorporation into clinical trials to stimulate effective and expedited drug development for recurrent glioblastoma by addressing 3 fundamental questions: (i) What is the current validation status of imaging response assessment, and when are we confident assessing response using today's technology? (ii) What imaging technology and/or response assessment paradigms can be validated and implemented soon, and how will these technologies provide benefit? (iii) Which imaging technologies need extensive testing, and how can they be prospectively validated? Assessment of T1 +/− contrast, T2/FLAIR, diffusion, and perfusion-imaging sequences are routine and provide important insight into underlying tumor activity. Nonetheless, utility of these data within and across patients, as well as across institutions, are limited by challenges in quantifying measurements accurately and lack of consistent and standardized image acquisition parameters. Currently, there exists a critical need to generate guidelines optimizing and standardizing MRI sequences for neuro-oncology patients. Additionally, more accurate differentiation of confounding factors (pseudoprogression or pseudoresponse) may be valuable. Although promising, diffusion MRI, perfusion MRI, MR spectroscopy, and amino acid PET require extensive standardization and validation. Finally, additional techniques to enhance response assessment, such as digital T1 subtraction maps, warrant further investigation. PMID:25313236

Sapphire reinforced alumina matrix composites

NASA Technical Reports Server (NTRS)

Jaskowiak, Martha H.; Setlock, John A.

1994-01-01

Unidirectionally reinforced A1203 matrix composites have been fabricated by hot pressing. Approximately 30 volume % of either coated or uncoated sapphire fiber was used as reinforcement. Unstabilized ZrO2 was applied as the fiber coating. Composite mechanical behavior was analyzed both after fabrication and after additional heat treatment. The results of composite tensile tests were correlated with fiber-matrix interfacial shear strengths determined from fiber push-out tests. Substantially higher strength and greater fiber pull-out were observed for the coated fiber composites for all processing conditions studied. The coated fiber composites retained up to 95% and 87% of their as-fabricated strength when heat treated at 14000C for 8 or 24 hours, respectively. Electron microscopy analysis of the fracture surfaces revealed extensive fiber pull-out both before and after heat treatment.

Resolution of Transverse Electron Beam Measurements using Optical Transition Radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ischebeck, Rasmus; Decker, Franz-Josef; Hogan, Mark

2005-06-22

In the plasma wakefield acceleration experiment E-167, optical transition radiation is used to measure the transverse profile of the electron bunches before and after the plasma acceleration. The distribution of the electric field from a single electron does not give a point-like distribution on the detector, but has a certain extension. Additionally, the resolution of the imaging system is affected by aberrations. The transverse profile of the bunch is thus convolved with a point spread function (PSF). Algorithms that deconvolve the image can help to improve the resolution. Imaged test patterns are used to determine the modulation transfer function ofmore » the lens. From this, the PSF can be reconstructed. The Lucy-Richardson algorithm is used to deconvolute this PSF from test images.« less

SysSon - A Framework for Systematic Sonification Design

NASA Astrophysics Data System (ADS)

Vogt, Katharina; Goudarzi, Visda; Holger Rutz, Hanns

2015-04-01

SysSon is a research approach on introducing sonification systematically to a scientific community where it is not yet commonly used - e.g., in climate science. Thereby, both technical and socio-cultural barriers have to be met. The approach was further developed with climate scientists, who participated in contextual inquiries, usability tests and a workshop of collaborative design. Following from these extensive user tests resulted our final software framework. As frontend, a graphical user interface allows climate scientists to parametrize standard sonifications with their own data sets. Additionally, an interactive shell allows to code new sonifications for users competent in sound design. The framework is a standalone desktop application, available as open source (for details see http://sysson.kug.ac.at/) and works with data in NetCDF format.

Thermal barrier coatings for aircraft engines: History and directions

NASA Technical Reports Server (NTRS)

Miller, R. A.

1995-01-01

Thin thermal barrier coatings for protecting aircraft turbine section airfoils are examined. The discussion focuses on those advances that led first to their use for component life extension and more recently as an integral part of airfoil design. It is noted that development has been driven by laboratory rig and furnace testing corroborated by engine testing and engine field experience. The technology has also been supported by performance modeling to demonstrate benefits and life modeling for mission analysis. Factors which have led to the selection of the current state-of-the-art plasma sprayed and physical vapor deposited zirconia-yttria/MCrAlY TBC's is emphasized in addition to observations fundamentally related to their behavior. Current directions in research into thermal barrier coatings and recent progress at NASA is also noted.

Robonaut 2 - Building a Robot on the International Space Station

NASA Technical Reports Server (NTRS)

Diftler, Myron; Badger, Julia; Joyce, Charles; Potter, Elliott; Pike, Leah

2015-01-01

In 2010, the Robonaut Project embarked on a multi-phase mission to perform technology demonstrations on-board the International Space Station (ISS), showcasing state of the art robotics technologies through the use of Robonaut 2 (R2). This phased approach implements a strategy that allows for the use of ISS as a test bed during early development to both demonstrate capability and test technology while still making advancements in the earth based laboratories for future testing and operations in space. While R2 was performing experimental trials onboard the ISS during the first phase, engineers were actively designing for Phase 2, Intra-Vehicular Activity (IVA) Mobility, that utilizes a set of zero-g climbing legs outfitted with grippers to grasp handrails and seat tracks. In addition to affixing the new climbing legs to the existing R2 torso, it became clear that upgrades to the torso to both physically accommodate the climbing legs and to expand processing power and capabilities of the robot were required. In addition to these upgrades, a new safety architecture was also implemented in order to account for the expanded capabilities of the robot. The IVA climbing legs not only needed to attach structurally to the R2 torso on ISS, but also required power and data connections that did not exist in the upper body. The climbing legs were outfitted with a blind mate adapter and coarse alignment guides for easy installation, but the upper body required extensive rewiring to accommodate the power and data connections. This was achieved by mounting a custom adapter plate to the torso and routing the additional wiring through the waist joint to connect to the new set of processors. In addition to the power and data channels, the integrated unit also required updated electronics boards, additional sensors and updated processors to accommodate a new operating system, software platform, and custom control system. In order to perform the unprecedented task of building a robot in space, extensive practice sessions and meticulous procedures were required. Since crew training time is at a premium, the R2 team took a skills-based training approach to ensure the astronauts were proficient with a basic skill set while refining the detailed procedures over several practice sessions and simulations. In addition to the crew activities, meticulous ground procedures were required in order to upgrade firmware on the upper body motor drivers. The new firmware for the IVA mobility unit needed to be deployed using the old software system. This also provided an opportunity to upgrade the upper body joints with new software and allowed for limited insight into the success of the updates. Complete verification that the updated firmware was successfully loaded was not confirmed until the rewiring of the upper body torso was complete.

Handheld hyperspectral imager for standoff detection of chemical and biological aerosols

NASA Astrophysics Data System (ADS)

Hinnrichs, Michele; Jensen, James O.; McAnally, Gerard

2004-08-01

Pacific Advanced Technology has developed a small hand held imaging spectrometer, Sherlock, for gas leak and aerosol detection and imaging. The system is based on a patented technique, (IMSS Image Multi-spectral Sensing), that uses diffractive optics and image processing algorithms to detect spectral information about objects in the scene of the camera. This cameras technology has been tested at Dugway Proving Ground and Dstl Porton Down facilities looking at Chemical and Biological agent simulants. In addition to Chemical and Biological detection, the camera has been used for environmental monitoring of green house gases and is currently undergoing extensive laboratory and field testing by the Gas Technology Institute, British Petroleum and Shell Oil for applications for gas leak detection and repair. In this paper we will present some of the results from the data collection at the TRE test at Dugway Proving Ground during the summer of 2002 and laboratory testing at the Dstl facility at Porton Down in the UK in the fall of 2002.

Experimental test program for evaluation of solid lubricant coating as applied to compliant foil gas bearings to 315 deg C

NASA Technical Reports Server (NTRS)

Wagner, R. C.

1985-01-01

An experimental apparatus and test procedure was developed to compare the performance of two solid lubricant coatings for air lubricated compliant foil gas bearings in the temperature range of 25 to 315 C. Polyimide bonded additive (SBGC) were tested extensively for durability and frictional characteristics. A partial arc bearing constructed of Inconel X-750 was coated on the bore with one of these coatings. The foil was subjected to repeated start/stop cycles. Performance comparisons reveal that although both coatings survive thousands of start/stop cycles, only the PBGF coated bearing achieves the specified 9000 start/stops. There is enough wear on the SBGC coated bearing to warrant termination of the test prior to 9000 start/stop cycles due to coating failure. The frictional characteristics of the PBGF are better at the elevated temperatures than at lower temperatures; a marked increase in sliding friction occurs as the temperature decreases. The SBGC maintains relatively constant frictional characteristics independent of operating temperature.

In-situ AFM measurement of single fibrin fiber stiffness before and after addition of Factor XIII

NASA Astrophysics Data System (ADS)

Houser, John; O'Brien, E. Timothy; Lord, Susan T.; Superfine, Richard; Falvo, Michael R.

2008-10-01

Fibrin fibers are the main structural component of blood clots. Ligation of fibrin by native Factor XIII (FXIII) serves to fine tune the mechanical properties of the clot. Mechanical alteration is important because a clot must be stiff enough to resist forces from blood flow but compliant enough to prevent embolism (fracture). Cone and Plate measurements of fibrin gels, which represent the vast majority of mechanical measurements on fibrin, show that FXIII increases clot stiffness. More recently, measurements on individual fibrin fibers show that they exhibit remarkable extensibility, breaking at strains up to 300%. As of yet, the origin of this extensibility is not fully understood. The different responses of ligated and unligated fibrin fibers can give us clues as to it's mechanism of extension. We use a combined fluorescence/atomic force microscope to stretch individual, isolated, fibrin fibers and then compare force extension curves of the same fiber before and after addition of FXIII. We found up to a 3.5-fold increase in fiber stiffness after addition of FXIII. We also show stiffening of individual fibrin fibers after crosslinking by gluteraldehyde.

COMPARISON OF DIFFERENT TRUNK ENDURANCE TESTING METHODS IN COLLEGE‐AGED INDIVIDUALS

PubMed Central

Krier, Amber D.; Nelson, Julie A.; Rogers, Michael A.; Stuke, Zachariah O.; Smith, Barbara S.

2012-01-01

Objective: Determine the reliability of two different modified (MOD1 and MOD2) testing methods compared to a standard method (ST) for testing trunk flexion and extension endurance. Participants: Twenty‐eight healthy individuals (age 26.4 ± 3.2 years, height 1.75 ± m, weight 71.8 ± 10.3 kg, body mass index 23.6 ± 3.4 m/kg2). Method: Trunk endurance time was measured in seconds for flexion and extension under the three different stabilization conditions. The MOD1 testing procedure utilized a female clinician (70.3 kg) and MOD2 utilized a male clinician (90.7 kg) to provide stabilization as opposed to the ST method of belt stabilization. Results: No significant differences occurred between flexion and extension times. Intraclass correlations (ICCs3,1) for the different testing conditions ranged from .79 to .95 (p <.000) and are found in Table 3. Concurrent validity using the ST flexion times as the gold standard coefficients were .95 for MOD1 and .90 for MOD2. For ST extension, coefficients were .91 and .80, for MOD1 and MOD2 respectively (p <.01). Conclusions: These methods proved to be a reliable substitute for previously accepted ST testing methods in normal college‐aged individuals. These modified testing procedures can be implemented in athletic training rooms and weight rooms lacking appropriate tables for the ST testing. Level of Evidence: 3 PMID:23091786

Using Maps in Web Analytics to Evaluate the Impact of Web-Based Extension Programs

ERIC Educational Resources Information Center

Veregin, Howard

2015-01-01

Maps can be a valuable addition to the Web analytics toolbox for Extension programs that use the Web to disseminate information. Extension professionals use Web analytics tools to evaluate program impacts. Maps add a unique perspective through visualization and analysis of geographic patterns and their relationships to other variables. Maps can…

Enhancing the Capacity to Create Behavior Change: Extension Key Leaders' Opinions about Social Marketing and Evaluation

ERIC Educational Resources Information Center

Warner, Laura A.

2014-01-01

Extension educators endeavor to create and measure outcomes beyond knowledge gain. The purpose of this qualitative study was to explore the role of social marketing as a method for creating behavior change within the University of Florida Extension system through key leader opinions. Additionally, the study sought to identify perceptions about…

Defining an additivity framework for mixture research in inducible whole-cell biosensors

NASA Astrophysics Data System (ADS)

Martin-Betancor, K.; Ritz, C.; Fernández-Piñas, F.; Leganés, F.; Rodea-Palomares, I.

2015-11-01

A novel additivity framework for mixture effect modelling in the context of whole cell inducible biosensors has been mathematically developed and implemented in R. The proposed method is a multivariate extension of the effective dose (EDp) concept. Specifically, the extension accounts for differential maximal effects among analytes and response inhibition beyond the maximum permissive concentrations. This allows a multivariate extension of Loewe additivity, enabling direct application in a biphasic dose-response framework. The proposed additivity definition was validated, and its applicability illustrated by studying the response of the cyanobacterial biosensor Synechococcus elongatus PCC 7942 pBG2120 to binary mixtures of Zn, Cu, Cd, Ag, Co and Hg. The novel method allowed by the first time to model complete dose-response profiles of an inducible whole cell biosensor to mixtures. In addition, the approach also allowed identification and quantification of departures from additivity (interactions) among analytes. The biosensor was found to respond in a near additive way to heavy metal mixtures except when Hg, Co and Ag were present, in which case strong interactions occurred. The method is a useful contribution for the whole cell biosensors discipline and related areas allowing to perform appropriate assessment of mixture effects in non-monotonic dose-response frameworks

Using Audience Response Devices for Extension Programming

ERIC Educational Resources Information Center

de Koff, Jason P.

2013-01-01

Audience response devices (ARDs), or "clickers," have traditionally been used in the classroom to take attendance, provide testing of current knowledge and knowledge gain, and assist with review of course topics. The ARDs were used at a recent Extension conference, which provided an opportunity to test how well this tool worked. Though…

Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 9: PEP design, development and test plans

NASA Technical Reports Server (NTRS)

1979-01-01

A plan for the production of two PEP flight systems is defined. The task's milestones are described. Provisions for the development and assembly of new ground support equipment required for both testing and launch operations are included.

77 FR 35464 - Modifications to the Disability Determination Procedures; Extension of Testing of Some Disability...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

...-772-1213 or TTY 1-800-325-0778, or visit our Internet site, Social Security Online, at http://www... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2012-0029] Modifications to the Disability Determination Procedures; Extension of Testing of Some Disability Redesign Features AGENCY: Social Security...

78 FR 45010 - Modifications to the Disability Determination Procedures; Extension of Testing of Some Disability...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-25

...-772-1213 or TTY 1-800-325-0778, or visit our Internet site, Social Security Online, at http://www... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2013-0030] Modifications to the Disability Determination Procedures; Extension of Testing of Some Disability Redesign Features AGENCY: Social Security...

78 FR 4120 - Notice of Request for Extension of Approval of an Information Collection; Tuberculosis Testing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service [Docket No. APHIS-2012-0098 ] Notice of Request for Extension of Approval of an Information Collection; Tuberculosis Testing of Imported Cattle From Mexico AGENCY: Animal and Plant Health Inspection Service, USDA. [[Page 4121

Biomechanical analysis of occipitocervical stability afforded by three fixation techniques.

PubMed

Helgeson, Melvin D; Lehman, Ronald A; Sasso, Rick C; Dmitriev, Anton E; Mack, Andrew W; Riew, K Daniel

2011-03-01

Occipital condyle screws appear to be a novel technique that demands biomechanical consideration. It has the potential to achieve fixation anterior to the axis of rotation while offering a point of fixation in line with the C1/C2 screws. To compare the segmental stability and range of motion (ROM) of standard occipitocervical (OC) screw/rod and plate constructs versus a new technique that incorporates occipital condyle fixation. Human cadaveric biomechanical analysis. After intact analysis, 10 fresh-frozen human cadaveric OC spine specimens were instrumented bilaterally with C1 lateral mass screws and C2 pedicle screws. Additional occipital instrumentation was tested in random order under the following conditions: standard occipitocervical plate/rod system (Vertex Max; Medtronic, Inc., Minneapolis, MN, USA); occipital condyle screws alone; and occipital condyle screws with the addition of an eyelet screw placed into the occiput bilaterally. After nondestructive ROM testing, specimens were evaluated under computed tomography (CT) and underwent destructive forward flexion failure comparing Group 1 to Group 3. There was no significant difference in OC (Occiput-C1) axial rotation and flexion/extension ROM between the standard occipitocervical plate/rod system (Group 1) and the occipital condyle screws with one eyelet screw bilaterally (Group 3). Furthermore, the occipital condyle screws alone (Group 2) did allow significantly more flexion/extension compared with Group 1. Interestingly, the two groups with occipital condyle screws (Groups 2 and 3) had significantly less lateral bending compared with Group 1. During CT analysis, the mean occipital condyle width was 10.8 mm (range, 9.1-12.7 mm), and the mean condylar length was 24.3 mm (range, 20.2-28.5). On destructive testing, there was no significant difference in forward flexion failure between Groups 1 and 3. With instrumentation across the mobile OC junction, our results indicate that similar stability can be achieved with occipital condyle screws/eyelet screws compared with the standard occipitocervical plate/rod system. Published by Elsevier Inc.

The Quiet Eye and Motor Expertise: Explaining the “Efficiency Paradox”

PubMed Central

Klostermann, André; Hossner, Ernst-Joachim

2018-01-01

It has been consistently reported that experts show longer quiet eye (QE) durations when compared to near-experts and novices. However, this finding is rather paradoxical as motor expertise is characterized by an economization of motor-control processes rather than by a prolongation in response programming, a suggested explanatory mechanism of the QE phenomenon. Therefore, an inhibition hypothesis was proposed that suggests an inhibition of non-optimal task solutions over movement parametrization, which is particularly necessary in experts due to the great extent and high density of their experienced task-solution space. In the current study, the effect of the task-solution space’ extension was tested by comparing the QE-duration gains in groups that trained a far-aiming task with a small number (low-extent) vs. a large number (high-extent) of task variants. After an extensive training period of more than 750 trials, both groups showed superior performance in post-test and retention test when compared to pretest and longer QE durations in post-test when compared to pretest. However, the QE durations dropped to baseline values at retention. Finally, the expected additional gain in QE duration for the high-extent group was not found and thus, the assumption of long QE durations due to an extended task-solution space was not confirmed. The findings were (by tendency) more in line with the density explanation of the inhibition hypothesis. This density argument suits research revealing a high specificity of motor skills in experts thus providing worthwhile options for future research on the paradoxical relation between the QE and motor expertise. PMID:29472882

Detection of bacterial contamination in platelet concentrates by a sensitive flow cytometric assay (BactiFlow): a multicentre validation study.

PubMed

Vollmer, T; Dreier, J; Schottstedt, V; Bux, J; Tapernon, K; Sibrowski, W; Kleesiek, K; Knabbe, C

2012-08-01

Bacterial contamination of platelet concentrates (PCs) still represents an ongoing risk. As a result of septic complications, particularly observed with older PCs, the shelf life of PCs has been reduced in Germany to 4 days. In this study, bacterial screening of PCs by BactiFlow (BF) flow cytometry was introduced in three German blood services to evaluate the robustness and applicability of the assay. Results were used to discuss the potential for the extension of PC shelf life to 5 days. A total of 1956 PCs were tested on days 4 or 5+ after PC production using the BF, whereas the BacT/Alert culture system served as reference method. Two PCs were confirmed positive by culture only and were identified as Propionibacterium acnes and Staphylococcus species. Two PCs were confirmed positive for Streptococcus mitis by BF and culture. Additionally, two PCs were culture-positive only in one culture bottle (aerobic: S. mitis and anaerobic: S. hominis). Retrospective analysis of bacterial growth kinetics provide the indication that corresponding bacterial titres were most likely below the BF analytical detection limit (<150 CFU mL(-1) ) and had probably no transfusion relevance. All remaining specimens were tested negative. Testing of PCs by BF was successfully implemented. The BF proved sufficient as a rapid screening method to improve PC safety. This study further provides data supporting the extension of PC shelf life to 5 days after negative BF testing on day 4. © 2012 The Authors. Transfusion Medicine © 2012 British Blood Transfusion Society.

Biomechanical Evaluation of the CD HORIZON Spire Z Spinal System With Pedicle and Facet Fixation.

PubMed

Godzik, Jakub; Kalb, Samuel; Martinez-Del-Campo, Eduardo; Newcomb, Anna G U S; Singh, Vaneet; Walker, Corey T; Chang, Steve W; Kelly, Brian P; Crawford, Neil R

2016-08-01

Human cadaveric biomechanical study. The aim of this study was to evaluate the biomechanics of lumbar motion segments instrumented with the CD HORIZON Spire Z plate system (Spire Z), a posterior supplemental fixation spinous process plate, alone and with additional fixation systems. Plates and pedicle screw/rod and facet screw implants are adjuncts to fusion. The plate limits motion, improving segmental stability and the fusion microenvironment. However, the degree to which the plate contributes to overall stability when used alone or in conjunction with additional instrumentation has not been described. Standard nondestructive flexibility tests were performed in 7 L2-L5 human cadaveric spines. Spinal stability was determined as mean range of motion (ROM) in flexion/extension, lateral bending, and axial rotation. Paired comparisons were made between five conditions: (1) intact/control; (2) Spire Z; (3) Spire Z with unilateral pedicle screw/rod system (Spire Z+UPS); (4) Spire Z with unilateral facet screw system (Spire Z+UFS); and (5) Spire Z with bilateral facet screw system (Spire Z+BFS). Stiffness and ROM data were compared using one-way analysis of variance, followed by repeated-measures Holm-Šidák tests. Spire Z was most effective in limiting flexion (20% of normal) and extension (24% of normal), but less effective in reducing lateral bending and axial rotation. In lateral bending, Spire Z+BFS and Spire Z+UPS constructs were not significantly different and demonstrated greater ROM reduction compared with Spire Z+UFS and Spire Z (P < 0.001). Spire Z+BFS demonstrated greatest stiffness in axial rotation compared with Spire Z+UPS (P = 0.025), Spire Z+UFS (P = 0.001), and Spire Z (P < 0.001). Spire Z+UPS was not significantly different from Spire Z+UFS (P = 0.21), and superior to Spire Z (P = 0.013). The Spire Z spinous process plate provides excellent immediate fixation, particularly for flexion and extension. While the hybrid Spire Z+BFS screw construct afforded the greatest stability, Spire Z+UPS demonstrated considerable promise. N/A.

Improved nine-node shell element MITC9i with reduced distortion sensitivity

NASA Astrophysics Data System (ADS)

Wisniewski, K.; Turska, E.

2017-11-01

The 9-node quadrilateral shell element MITC9i is developed for the Reissner-Mindlin shell kinematics, the extended potential energy and Green strain. The following features of its formulation ensure an improved behavior: 1. The MITC technique is used to avoid locking, and we propose improved transformations for bending and transverse shear strains, which render that all patch tests are passed for the regular mesh, i.e. with straight element sides and middle positions of midside nodes and a central node. 2. To reduce shape distortion effects, the so-called corrected shape functions of Celia and Gray (Int J Numer Meth Eng 20:1447-1459, 1984) are extended to shells and used instead of the standard ones. In effect, all patch tests are passed additionally for shifts of the midside nodes along straight element sides and for arbitrary shifts of the central node. 3. Several extensions of the corrected shape functions are proposed to enable computations of non-flat shells. In particular, a criterion is put forward to determine the shift parameters associated with the central node for non-flat elements. Additionally, the method is presented to construct a parabolic side for a shifted midside node, which improves accuracy for symmetric curved edges. Drilling rotations are included by using the drilling Rotation Constraint equation, in a way consistent with the additive/multiplicative rotation update scheme for large rotations. We show that the corrected shape functions reduce the sensitivity of the solution to the regularization parameter γ of the penalty method for this constraint. The MITC9i shell element is subjected to a range of linear and non-linear tests to show passing the patch tests, the absence of locking, very good accuracy and insensitivity to node shifts. It favorably compares to several other tested 9-node elements.

Addressing the risk of bacterial contamination in platelets: a hospital economic perspective.

PubMed

Li, Justin W; Brecher, Mark E; Jacobson, Jessica L; Harm, Sarah K; Chen, Dorothy; El-Gamil, Audrey; Dobson, Al; Mintz, Paul D

2017-10-01

Bacterially contaminated platelets (PLTs) remain a serious risk. The Food and Drug Administration has issued draft guidance recommending hospitals implement secondary testing or transfuse PLTs that have been treated with pathogen reduction technology (PRT). The cost implications of these approaches are not well understood. We modeled incurred costs when hospitals acquire, process, and transfuse PLTs that are PRT treated with INTERCEPT (Cerus Corp.) or secondary tested with the PLT PGD Test (Verax Biomedical). Hospitals will spend $221.27 (30.0%) more per PRT-treated apheresis PLT unit administered compared to a Zika-tested apheresis PLT unit that is irradiated and PGD tested in hospital. This difference is reflected in PRT PLT units having: 1) a higher hospital purchase price ($100.00 additional charge compared to an untreated PLT); 2) lower therapeutic effectiveness than untreated PLTs among hematologic-oncologic patients, which contributes to additional transfusions ($96.05); or 3) fewer PLT storage days, which contributes to higher outdating cost from expired PLTs ($67.87). Only a small portion of the incremental costs for PRT-treated PLTs are offset by costs that may be avoided, including primary bacterial culture, secondary bacterial testing ($26.65), hospital irradiation ($8.50), Zika testing ($4.47), and other costs ($3.03). The significantly higher cost of PRT-treated PLTs over PGD-tested PLTs should interest stakeholders. For hospitals that outdate PLTs, savings associated with expiration extension to 7 days by adding PGD testing will likely be substantially greater than the cost of implementing PGD-testing. Our findings might usefully inform a hospital's decision to select a particular blood safety approach. © 2017 The Authors Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.

Laboratory band strengths of methane and their application to the atmospheres of Jupiter, Saturn, Uranus, Neptune, and Titan. II - The red region 6000-7600 A

NASA Technical Reports Server (NTRS)

Lutz, B. L.; Owen, T.; Cess, R. D.

1982-01-01

Lutz et al. (1976) have reported the first quantitative analyses of the strengths of the blue-green bands of methane which dominate the visible spectra of the outer planets. The present investigation represents an extension of the first study to include a number of bands between 6000 and 7500 A. The objective of this extension is to establish the validity of the scaled numerical curve of growth of the first study further into the saturated region and to test the apparent pressure independence of the high-overtone bands over a large pressure range. In addition, it is desired to provide a set of homogeneously determined band strengths and curves of growth over a large spectral region and over a large range of band strengths. This will make it possible to investigate feasible apparent dependences of planetary methane abundances on wavelength and band strength as a probe of the scattering processes in the planetary atmospheres.

Don't Mess with the NEST

NASA Astrophysics Data System (ADS)

Larson, Michael

2012-03-01

This presentation will describe the history of the Nuclear Emergency Support Team (NEST) and its evolution over the years. NEST was formed due to a number of nuclear extortion threats received in the early 1970s. From the beginning NEST developed an extensive exercise program to test and expand capabilities. The Nuclear Assessment Program (NAP) was developed, in part, to determine if NEST deployments were required. A major revamp of the NEST program occurred in 1994. Many other organizations work in conjunction with NEST in particular the FBI and DOD. Considerable research and development has been performed in the areas of Access, Search, Diagnostics, Device Assessment, and Disablement. Extensive searches of material appearing in the unclassified literature have been and are being performed to see what is being said about nuclear materials and devices. A comprehensive study of Improvised Nuclear Devices (IND) is ongoing to determine what a terrorist can and cannot do. NEST now consists of four phases with the latest additions of Phase III, Disposition and Phase IV, Nuclear Forensics. LLNL-ABS-521775

A Decision Tree for Nonmetric Sex Assessment from the Skull.

PubMed

Langley, Natalie R; Dudzik, Beatrix; Cloutier, Alesia

2018-01-01

This study uses five well-documented cranial nonmetric traits (glabella, mastoid process, mental eminence, supraorbital margin, and nuchal crest) and one additional trait (zygomatic extension) to develop a validated decision tree for sex assessment. The decision tree was built and cross-validated on a sample of 293 U.S. White individuals from the William M. Bass Donated Skeletal Collection. Ordinal scores from the six traits were analyzed using the partition modeling option in JMP Pro 12. A holdout sample of 50 skulls was used to test the model. The most accurate decision tree includes three variables: glabella, zygomatic extension, and mastoid process. This decision tree yielded 93.5% accuracy on the training sample, 94% on the cross-validated sample, and 96% on a holdout validation sample. Linear weighted kappa statistics indicate acceptable agreement among observers for these variables. Mental eminence should be avoided, and definitions and figures should be referenced carefully to score nonmetric traits. © 2017 American Academy of Forensic Sciences.

Intelligent Engine Systems: Acoustics

NASA Technical Reports Server (NTRS)

Wojno, John; Martens, Steve; Simpson, Benjamin

2008-01-01

An extensive study of new fan exhaust nozzle technologies was performed. Three new uniform chevron nozzles were designed, based on extensive CFD analysis. Two new azimuthally varying variants were defined. All five were tested, along with two existing nozzles, on a representative model-scale, medium BPR exhaust nozzle. Substantial acoustic benefits were obtained from the uniform chevron nozzle designs, the best benefit being provided by an existing design. However, one of the azimuthally varying nozzle designs exhibited even better performance than any of the uniform chevron nozzles. In addition to the fan chevron nozzles, a new technology was demonstrated, using devices that enhance mixing when applied to an exhaust nozzle. The acoustic benefits from these devices applied to medium BPR nozzles were similar, and in some cases superior to, those obtained from conventional uniform chevron nozzles. However, none of the low noise technologies provided equivalent acoustic benefits on a model-scale high BPR exhaust nozzle, similar to current large commercial applications. New technologies must be identified to improve the acoustics of state-of-the-art high BPR jet engines.

Towards Resilient Critical Infrastructures: Application of Type-2 Fuzzy Logic in Embedded Network Security Cyber Sensor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ondrej Linda; Todd Vollmer; Jim Alves-Foss

2011-08-01

Resiliency and cyber security of modern critical infrastructures is becoming increasingly important with the growing number of threats in the cyber-environment. This paper proposes an extension to a previously developed fuzzy logic based anomaly detection network security cyber sensor via incorporating Type-2 Fuzzy Logic (T2 FL). In general, fuzzy logic provides a framework for system modeling in linguistic form capable of coping with imprecise and vague meanings of words. T2 FL is an extension of Type-1 FL which proved to be successful in modeling and minimizing the effects of various kinds of dynamic uncertainties. In this paper, T2 FL providesmore » a basis for robust anomaly detection and cyber security state awareness. In addition, the proposed algorithm was specifically developed to comply with the constrained computational requirements of low-cost embedded network security cyber sensors. The performance of the system was evaluated on a set of network data recorded from an experimental cyber-security test-bed.« less

Small Scale Trace Contaminant Testing of SA9T at Ambient and Reduced Pressure Conditions

NASA Technical Reports Server (NTRS)

Broerman, Craig; Sweterlitsch, Jeffrey

2011-01-01

A principle concern for air revitalization technology in a closed loop system is the capability to control carbon dioxide (CO2) and humidity (H2O). An amine based sorbent technology, SA9T, has long been evaluated for use in this application and several programs are evaluating it for use in both a cabin as well as space suit applications. While the CO2 and H2O performance of the sorbent has been tested extensively, the question of how trace contaminants impact performance requires further evaluation. This paper presents experimental results of small scale SA9T testing that was performed over a variety of test conditions and with a variety of trace contaminants. Testing evaluated the ability of SA9T media to sufficiently remove CO2 and H2O after exposure to a fully saturated trace contaminant at ambient conditions. Testing also evaluated the impact of CO2 and H2O removal performance at suit loop pressures during cyclic operation with a constant inlet contaminant load. In addition, testing evaluated the performance of SA9T at ambient conditions in a continuous 30-day test with a mixed trace contaminant stream.

The NASA modern technology rotors program

NASA Technical Reports Server (NTRS)

Watts, M. E.; Cross, J. L.

1986-01-01

Existing data bases regarding helicopters are based on work conducted on 'old-technology' rotor systems. The Modern Technology Rotors (MTR) Program is to provide extensive data bases on rotor systems using present and emerging technology. The MTR is concerned with modern, four-bladed, rotor systems presently being manufactured or under development. Aspects of MTR philosophy are considered along with instrumentation, the MTR test program, the BV 360 Rotor, and the UH-60 Black Hawk. The program phases include computer modelling, shake test, model-scale test, minimally instrumented flight test, extensively pressure-instrumented-blade flight test, and full-scale wind tunnel test.

Development of low-cost welding procedures for thick sections of HY-150 steel

NASA Technical Reports Server (NTRS)

Schmidt, P. M.; Snow, R. S.

1972-01-01

Low cost welding procedures were developed for welding 6-inch thick HY-150 steel to be used in the manufacture of large diameter motor case Y rings and nozzle attachment flanges. An extensive investigation was made of the mechanical and metallurgical properties and fracture toughness of HY-150 base plate and welds made with manual shielded metal arc process and semi-automatic gas metal arc process in the flat position. Transverse tensiles, all-weld metal tensiles, Charpy V-notch specimens and edge notched bend specimens were tested in the course of the program. In addition metallographic studies and hardness tests were performed on the weld, weld HAZ and base metal. The results of the work performed indicate that both the shielded metal arc and gas metal arc processes are capable of producing consistently sound welds as determined by radiographic and ultrasonic inspection. In addition, the weld metal, deposited by each process was found to exhibit a good combination of strength and toughness such that the selection of a rolled and welded procedure for fabricating rocket motor case components would appear to be technically feasible.

Nonlinear Unsteady Aerodynamic Modeling Using Wind Tunnel and Computational Data

NASA Technical Reports Server (NTRS)

Murphy, Patrick C.; Klein, Vladislav; Frink, Neal T.

2016-01-01

Extensions to conventional aircraft aerodynamic models are required to adequately predict responses when nonlinear unsteady flight regimes are encountered, especially at high incidence angles and under maneuvering conditions. For a number of reasons, such as loss of control, both military and civilian aircraft may extend beyond normal and benign aerodynamic flight conditions. In addition, military applications may require controlled flight beyond the normal envelope, and civilian flight may require adequate recovery or prevention methods from these adverse conditions. These requirements have led to the development of more general aerodynamic modeling methods and provided impetus for researchers to improve both techniques and the degree of collaboration between analytical and experimental research efforts. In addition to more general mathematical model structures, dynamic test methods have been designed to provide sufficient information to allow model identification. This paper summarizes research to develop a modeling methodology appropriate for modeling aircraft aerodynamics that include nonlinear unsteady behaviors using both experimental and computational test methods. This work was done at Langley Research Center, primarily under the NASA Aviation Safety Program, to address aircraft loss of control, prevention, and recovery aerodynamics.

Rheological Properties of Quasi-2D Fluids in Microgravity

NASA Technical Reports Server (NTRS)

Trittel, Torsten; Stannarius, Ralf; Eremin, Alexey; Harth, Kirsten; Clark, Noel A.; Maclennan, Joseph; Glaser, Matthew; Park, Cheol; Hall, Nancy; Tin, Padetha

2016-01-01

Freely suspended smectic films of sub-micrometer thickness and lateral extensions of several millimeters are used to study thermally driven convection and diffusion in the film plane. The experiments were performed during a six minute microgravity phase of a TEXUS suborbital rocket flight (Texus 52, launched April 27, 2015). The project served as a preliminary test for a planned ISS Experiment with liquid crystal films (OASIS), and in addition it provided new experimental data on smectic films exposed to in-plane thermal gradients.We find an attraction of the smectic material towards the cold edge of the film in a temperature gradient, similar to a Soret effect. This process is reversed when this edge is heated up again. Thermal convection driven by two thermocontacts in the film is practically absent, even at temperature gradients up to 10 Kmm, thermally driven convection sets in when the hot post reaches the transition temperature to the nematic phase.An additional experiment was performed under microgravity conditions to test the stability of liquid crystal bridges in different smectic phases.

CINTEX: International Interoperability Extensions to EOSDIS

NASA Technical Reports Server (NTRS)

Graves, Sara J.

1997-01-01

A large part of the research under this cooperative agreement involved working with representatives of the DLR, NASDA, EDC, and NOAA-SAA data centers to propose a set of enhancements and additions to the EOSDIS Version 0 Information Management System (V0 IMS) Client/Server Message Protocol. Helen Conover of ITSL led this effort to provide for an additional geographic search specification (WRS Path/Row), data set- and data center-specific search criteria, search by granule ID, specification of data granule subsetting requests, data set-based ordering, and the addition of URLs to result messages. The V0 IMS Server Cookbook is an evolving document, providing resources and information to data centers setting up a VO IMS Server. Under this Cooperative Agreement, Helen Conover revised, reorganized, and expanded this document, and converted it to HTML. Ms. Conover has also worked extensively with the IRE RAS data center, CPSSI, in Russia. She served as the primary IMS contact for IRE-CPSSI and as IRE-CPSSI's liaison to other members of IMS and Web Gateway (WG) development teams. Her documentation of IMS problems in the IRE environment (Sun servers and low network bandwidth) led to a general restructuring of the V0 IMS Client message polling system. to the benefit of all IMS participants. In addition to the IMS server software and documentation. which are generally available to CINTEX sites, Ms. Conover also provided database design documentation and consulting, order tracking software, and hands-on testing and debug assistance to IRE. In the final pre-operational phase of IRE-CPSSI development, she also supplied information on configuration management, including ideas and processes in place at the Global Hydrology Resource Center (GHRC), an EOSDIS data center operated by ITSL.

Cost effectiveness of the addition of a comprehensive CT scan to the abdomen and pelvis for the detection of cancer after unprovoked venous thromboembolism.

PubMed

Coyle, Kathryn; Carrier, Marc; Lazo-Langner, Alejandro; Shivakumar, Sudeep; Zarychanski, Ryan; Tagalakis, Vicky; Solymoss, Susan; Routhier, Nathalie; Douketis, James; Coyle, Douglas

2017-03-01

Unprovoked venous thromboembolism (VTE) can be the first manifestation of cancer. It is unclear if extensive screening for occult cancer including a comprehensive computed tomography (CT) scan of the abdomen/pelvis is cost-effective in this patient population. To assess the health care related costs, number of missed cancer cases and health related utility values of a limited screening strategy with and without the addition of a comprehensive CT scan of the abdomen/pelvis and to identify to what extent testing should be done in these circumstances to allow early detection of occult cancers. Cost effectiveness analysis using data that was collected alongside the SOME randomized controlled trial which compared an extensive occult cancer screening including a CT of the abdomen/pelvis to a more limited screening strategy in patients with a first unprovoked VTE, was used for the current analyses. Analyses were conducted with a one-year time horizon from a Canadian health care perspective. Primary analysis was based on complete cases, with sensitivity analysis using appropriate multiple imputation methods to account for missing data. Data from a total of 854 patients with a first unprovoked VTE were included in these analyses. The addition of a comprehensive CT scan was associated with higher costs ($551 CDN) with no improvement in utility values or number of missed cancers. Results were consistent when adopting multiple imputation methods. The addition of a comprehensive CT scan of the abdomen/pelvis for the screening of occult cancer in patients with unprovoked VTE is not cost effective, as it is both more costly and not more effective in detecting occult cancer. Copyright © 2017 Elsevier Ltd. All rights reserved.

Evaluation of coated columbium test panels having application to a secondary nozzle extension for the RL10 rocket engine system, parts 1 and 2

NASA Technical Reports Server (NTRS)

Murphy, Kenneth S.; Castro, Joaquin H.

1988-01-01

The activity performed on the screening and evaluation of various coatings for application on columbium alloy test panels representative of a radiation-cooled nozzle extension for the RL10 rocket engine is summarized. Vendors and processes of candidate coatings were evaluated. Post engine test evaluations of the two selected coatings are discussed.

Analysis of Chemical Bioactivity through In Vitro Profiling ...

EPA Pesticide Factsheets

Safety assessment of drugs and environmental chemicals relies extensively on animal testing. However, the quantity of chemicals needing assessment and challenges of species extrapolation drive the development of alternative approaches. The EPA’s ToxCast and the multiagency Tox21 programs address this through use of an extensive in vitro screening program to generate data on a large library of important environmental chemicals. These in vitro assays encompass both cell-free, biochemical assays targeting proteins that may be potential molecular initiating events and cellular assays that provide coverage of critical signaling pathways and toxicity phenotypes. Effects on model organisms such as the developing zebrafish, are also part of the testing strategy. A variety of computational approaches are used to analyze the resulting complex data sets to gain insight in to inherent biological activity of chemicals and possible mechanisms of toxicity. Several case studies including identification of modulators of estrogen receptor and aromatic hydrocarbon receptor pathways with effects in primary human cell systems will be described. In addition, existing in vivo data from a subset of the chemicals was used to anchor predictive models using in vitro data for a number of adverse endpoints including reproductive and developmental toxicities. The strengths and weaknesses of this approach will be described. This work does not necessarily reflect official Agency policy. Pres

Test Capabilities and Recent Experiences in the NASA Langley 8-Foot High Temperature Tunnel

NASA Technical Reports Server (NTRS)

Hodge, Jeffrey S.; Harvin, Stephen F.

2000-01-01

The NASA Langley 8-Foot High Temperature Tunnel is a combustion-heated hypersonic blowdown-to-atmosphere wind tunnel that provides flight enthalpy simulation for Mach numbers of 4, 5, and 7 through an altitude range from 50,000 to 120,000 feet. The open-.jet test section is 8-ft. in diameter and 12-ft. long. The test section will accommodate large air-breathing hypersonic propulsion systems as well as structural and thermal protection system components. Stable wind tunnel test conditions can be provided for 60 seconds. Additional test capabilities are provided by a radiant heater system used to simulate ascent or entry heating profiles. The test medium is the combustion products of air and methane that are burned in a pressurized combustion chamber. Oxygen is added to the test medium for air-breathing propulsion tests so that the test gas contains 21 percent molar oxygen. The facility was modified extensively in the late 1980's to provide airbreathing propulsion testing capability. In this paper, a brief history and general description of the facility are presented along with a discussion of the types of supported testing. Recently completed tests are discussed to explain the capabilities this facility provides and to demonstrate the experience of the staff.

Comparison of the clinical efficacy between tigecycline plus extended-infusion imipenem and sulbactam plus imipenem against ventilator-associated pneumonia with pneumonic extensively drug-resistant Acinetobacter baumannii bacteremia, and correlation of clinical efficacy with in vitro synergy tests.

PubMed

Jean, Shio-Shin; Hsieh, Tai-Chin; Hsu, Chin-Wan; Lee, Wen-Sen; Bai, Kuan-Jen; Lam, Carlos

2016-12-01

To compare the clinical efficacy between salvage antimicrobial regimen consisting of tigecycline plus extended-infusion imipenem/cilastatin (TIC) and regimen of sulbactam plus imipenem/cilastatin (SIC) for patients with ventilator-associated pneumonia and pneumonic bacteremia due to extensively drug-resistant (XDR) Acinetobacter baumannii (Ab) isolates, and determine the correlation of results of in vitro tigecycline-imipenem synergy test with clinical efficacy. The comparative survey was conducted at a medical center in Taiwan in 2013. Patients comprising the TIC group (n = 28) received tigecycline plus extended-infusion imipenem/cilastatin following unresponsiveness to 3-day sulbactam-imipenem/cilastatin therapy, and those in the SIC group (n = 56) received sulbactam-imipenem/cilastatin throughout the course. Univariate and multivariate analyses were applied to explore 30-day case-fatality independent predictors. Additionally, the checkerboard test and time-kill analysis were performed for the bloodstream XDR-Ab isolates from patients in the TIC group, and molecular characterization was done for the bloodstream XDR-Ab strains of all patients. We found that the TIC scheme has a significant benefit on improving patients' survival status (the mortality rate of TIC and SIC group patients was 14.3% and 64.3%, respectively), corresponding well with in vitro synergy or additivity results by the checkerboard test. Twenty TIC group cases had monomicrobial XDR-Ab cultured from tracheal aspirates after 10 days of tigecycline-imipenem/cilastatin therapy, but none developed subsequent pneumonia. However, breakthrough primary Burkholderia cepacia (n = 3) and Pseudomonas aeruginosa (n = 1) bacteremias were attributed to four TIC case fatalities. Shock, SIC regimen usage, and development of breakthrough bacteremia were independent predictors of 30-day in-hospital mortality. Although the TIC regimen showed good efficacy, its value regarding managing XDR-Ab ventilator-associated pneumonia bacteremia needs further evaluation. Copyright © 2015. Published by Elsevier B.V.

Biodegradation of clotrimazole and modification of cell properties after metabolic stress and upon addition of saponins.

PubMed

Pacholak, A; Simlat, J; Zgoła-Grześkowiak, A; Kaczorek, E

2018-06-20

Azole fungicides constitute an extensive group of potential emerging pollutants which can be found in natural environment. This study focuses on the biodegradation of clotrimazole and the characterization of cell surface properties of microorganisms capable of degradation of this compound. The influence of long-term contact of bacteria with clotrimazole and the impact of the addition of Saponaria officinalis extract on cell surface modification was also checked. The biodegradation of clotrimazole did not exceed 70%. The presence of plant extract increased biodegradation of fungicide. The cells metabolic activity after one-month exposure to clotrimazole was the highest for each tested strain. Moreover, metabolic stress led to a strong modification of cell surface properties. The results are promising for determining the impact of clotrimazole on environmental microorganisms. Copyright © 2018 Elsevier Inc. All rights reserved.

Astrophysical black holes in screened modified gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Anne-Christine; Jha, Rahul; Muir, Jessica

2014-08-01

Chameleon, environmentally dependent dilaton, and symmetron gravity are three models of modified gravity in which the effects of the additional scalar degree of freedom are screened in dense environments. They have been extensively studied in laboratory, cosmological, and astrophysical contexts. In this paper, we present a preliminary investigation into whether additional constraints can be provided by studying these scalar fields around black holes. By looking at the properties of a static, spherically symmetric black hole, we find that the presence of a non-uniform matter distribution induces a non-constant scalar profile in chameleon and dilaton, but not necessarily symmetron gravity. Anmore » order of magnitude estimate shows that the effects of these profiles on in-falling test particles will be sub-leading compared to gravitational waves and hence observationally challenging to detect.« less

Improved recovery demonstration for Williston Basin carbonates. Annual report, June 10, 1995--June 9, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carrell, L.A.; Sippel, M.A.

1996-09-01

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in-place, methods for improved completion efficiency and the suitability of waterflooding in Red River and Ratcliffe shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing three-dimensional and multi-component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with extended-reach jetting lance and other ultra-short-radius lateral technologies. Improved completion efficiency, additional wells at closer spacing andmore » better estimates of oil in place will result in additional oil recovery by primary and enhanced recovery processes.« less

76 FR 62831 - Public Land Order No. 7784; Extension of Public Land Order No. 6886; Wyoming

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

.... 6886 for an additional 20-year period. This extension is necessary to continue the protection of the... device for the deaf (TDD) may call the Federal Information Relay Service (FIRS) at 1-800-877-8339 to... withdrawal was first made requires this extension in order to continue the protection of the unique...

76 FR 61737 - Public Land Order No. 7782; Extension of Public Land Order No. 6880; Oregon

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... an additional 20-year period. The extension is necessary to continue protection of the scientific and... Information Relay Service (FIRS) at 1-800- 877-8339 to reach the BLM contact during normal business hours. The... which the withdrawal was first made requires this extension in order to continue the protection of the...

Seroprevalence and risk factors associated with Brucella seropositivity in dairy and mixed cattle herds from Ecuador.

PubMed

Carbonero, A; Guzmán, L T; García-Bocanegra, I; Borge, C; Adaszek, L; Arenas, A; Saa, L R

2018-01-01

An extensive cross-sectional study to determine the seroprevalence of and associated risk factors for Brucella infection was performed in dairy and mixed (dairy-beef) cattle herds in Ecuador. A total of 2666 serum samples from 386 farms were analyzed using Rose Bengal test and a blocking ELISA test. In addition, a questionnaire with 57 variables related to management, feeding, facilities, biosecurity, and animal health was filled in every cattle farm. A Generalized Estimating Equations model was used to determine the factors associated with Brucella seropositivity. The true prevalence of Brucella seropositivity in dairy and mixed cattle from Ecuador reached 17.0% (CI95% 15.6-18.4%). The herd prevalence was 45.1% (174/386) (CI95% 40.1-50.1%), and the within-herd prevalence ranged from 10 to 100% (mean 38.9%; Q1 14.3%, Q2 26.8%, Q3 52.5%). Seven factors were included in the GEE model for Brucella seropositivity: the nominal variables sex (OR 2.03; CI95% 1.32-3.13), herd type (dairy) (OR 1.79; CI95% 1.11-2.87), closed facilities in the farm (OR 1.80; CI95% 1.19-2.74), and ad libitum feeding (OR: 0.32; CI95%: 0.19-0.54), and the quantitative variables age (OR 1.005; CI95% 1.001-1.009), average slope in the farm (%) (OR 1.013; CI95% 1.002-1.024), and annual abortion rate (OR 1.016; CI95% 1.002-1.031). This study remarks the high spread of Brucella infection in cattle farms from Ecuador. In addition, it reports the risk factors associated to this infection in the predominant extensive system existent in this country.

Space Shuttle Columbia Aging Wiring Failure Analysis

NASA Technical Reports Server (NTRS)

McDaniels, Steven J.

2005-01-01

A Space Shuttle Columbia main engine controller 14 AWG wire short circuited during the launch of STS-93. Post-flight examination divulged that the wire had electrically arced against the head of a nearby bolt. More extensive inspection revealed additional damage to the subject wire, and to other wires as well from the mid-body of Columbia. The shorted wire was to have been constructed from nickel-plated copper conductors surrounded by the polyimide insulation Kapton, top-coated with an aromatic polyimide resin. The wires were analyzed via scanning electron microscope (SEM), energy dispersive X-Ray spectroscopy (EDX), and electron spectroscopy for chemical analysis (ESCA); differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA) were performed on the polyimide. Exemplar testing under laboratory conditions was performed to replicate the mechanical damage characteristics evident on the failed wires. The exemplar testing included a step test, where, as the name implies, a person stepped on a simulated wire bundle that rested upon a bolt head. Likewise, a shear test that forced a bolt head and a torque tip against a wire was performed to attempt to damage the insulation and conductor. Additionally, a vibration test was performed to determine if a wire bundle would abrade when vibrated against the head of a bolt. Also, an abrasion test was undertaken to determine if the polyimide of the wire could be damaged by rubbing against convolex helical tubing. Finally, an impact test was performed to ascertain if the use of the tubing would protect the wire from the strike of a foreign object.

Acute effect and time course of extension and internal rotation stretching of the shoulder on infraspinatus muscle hardness.

PubMed

Kusano, Ken; Nishishita, Satoru; Nakamura, Masatoshi; Tanaka, Hiroki; Umehara, Jun; Ichihashi, Noriaki

2017-10-01

A decrease in flexibility of the infraspinatus muscle causes limitations in the range of shoulder motion. Static stretching (SS) is a useful method to improve muscle flexibility and joint mobility. Previous researchers investigated effective stretching methods for the infraspinatus. However, few researchers investigated the acute effect of SS on the infraspinatus muscle's flexibility. In addition, the minimum SS time required to increase the infraspinatus muscle's flexibility remains unclear. The aims of this study included investigating the acute effect of SS on the infraspinatus muscle's hardness (an index of muscle flexibility) by measuring shear elastic modulus and determining minimum SS time to decrease the infraspinatus muscle's hardness. This included measuring the effect of SS with extension and internal rotation of the shoulder on the infraspinatus muscle's hardness in 20 healthy men. Hence, shear elastic modulus of the infraspinatus was measured by ultrasonic shear wave elastography before and after every 10 seconds up to 120 seconds of SS. Two-way analysis of variance indicated a significant main effect of SS duration on shear elastic modulus. The post hoc test indicated no significant difference between shear elastic modulus after 10 seconds of SS and that before SS. However, shear elastic modulus immediately after a period ranging from 20 seconds to 120 seconds of SS was significantly lower than that before SS. The results suggested that shoulder extension and internal rotation SS effectively decreased the infraspinatus muscle's hardness. In addition, the results indicated that a period exceeding 20 seconds of SS decreased the infraspinatus muscle's hardness. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Acute effect of different concentrations of cayenne pepper cataplasm on sensory-motor functions and serum levels of inflammation-related biomarkers in healthy subjects.

PubMed

Sarabon, Nejc; Löfler, Stefan; Cvecka, Jan; Hübl, Wolfgang; Zampieri, Sandra

2018-01-12

Physical medicine therapies are often used in treating widespread musculoskeletal disorders, such as neck and low back pain. Herbal cataplasms containing rubefacient substances, such as Cayenne pepper, or galenic preparations like Munari cataplasm are commonly used as natural medications to treat painful areas. In this paper we show the effects of a 20-min application of Cayenne pepper and kaolin powder cataplasm (CPC) on healthy subjects. Treatment effects were evaluated by cold/hot feeling on visual analogue scale, blood pressure, body temperature, skin light touch sensations, two-point discrimination, and pain threshold to a mechanical stimulus, before and immediately after, 15 min after and 30 min after different concentration of Cayenne pepper in CPC preparation on healthy subjects. Maximal voluntary trunk extension force and trunk extension submaximal force matching error were also measured. In addition, the resulting optimal CPC mixture was tested for its safety by measuring changes in circulating levels of inflammatory-related biomarkers after 20-min application. The results indicate that the 5% concentration of Cayenne pepper in the preparation of CPC is the best choice, since no additional effects can be obtained with the 10% concentration, and the effects are higher than those observed at the 2.5% concentration. Importantly, 5% CPC application did not induce a significant increase of inflammatory-related biomarkers, suggesting that 20-min application has no negative side effects at systemic levels. Further studies are needed to investigate the immediate and long-term effects of repeated CPC applications as well as to understand the intersecting underlying mechanisms activated by Capsaicin and other identified factors, in order to be more extensively used in the field of physical medicine therapies.

Adjacent-Level Hypermobility and Instrumented-Level Fatigue Loosening With Titanium and PEEK Rods for a Pedicle Screw System: An In Vitro Study.

PubMed

Agarwal, Aakas; Ingels, Marcel; Kodigudla, Manoj; Momeni, Narjes; Goel, Vijay; Agarwal, Anand K

2016-05-01

Adjacent-level disease is a common iatrogenic complication seen among patients undergoing spinal fusion for low back pain. This is attributed to the postsurgical differences in stiffness between the spinal levels, which result in abnormal forces, stress shielding, and hypermobility at the adjacent levels. In addition, as most patients undergoing these surgeries are osteoporotic, screw loosening at the index level is a complication that commonly accompanies adjacent-level disease. Recent studies indicate that a rod with lower rigidity than that of titanium may help to overcome these detrimental effects at the adjacent level. The present study was conducted in vitro using 12 L1-S1 specimens divided into groups of six, with each group instrumented with either titanium rods or PEEK (polyetheretherketone) rods. The test protocol included subjecting intact specimens to pure moments of 10 Nm in extension and flexion using an FS20 Biomechanical Spine Test System (Applied Test Systems) followed by hybrid moments on the instrumented specimens to achieve the same L1-S1 motion as that of the intact specimens. During the protocol's later phase, the L4-L5 units from each specimen were segmented for cyclic loading followed by postfatigue kinematic analysis to highlight the differences in motion pre- and postfatigue. The objectives included the in vitro comparison of (1) the adjacent-level motion before and after instrumentation with PEEK and titanium rods and (2) the pre- and postfatigue motion at the instrumented level with PEEK and titanium rods. The results showed that the adjacent levels above the instrumentation caused increased flexion and extension with both PEEK and titanium rods. The postfatigue kinematic data showed that the motion at the instrumented level (L4-L5) increased significantly in both flexion and extension compared to prefatigue motion in titanium groups. However, there was no significant difference in motion between the pre- and postfatigue data in the PEEK group.

Communications for UAS Integration in the NAS Phase 2 Satellite Communications and Terrestrial Extension

NASA Technical Reports Server (NTRS)

Griner, Jim; Kerczewski, Bob

2017-01-01

In order to provide for the safe integration of unmanned aircraft systems (UAS) into the National Airspace System, the command and control communications link connecting the ground-based pilot with the unmanned aircraft must be highly reliable and robust, with national and international standards to enable interoperability and certification. Both line-of-sight (LOS) links using terrestrial-based communications and beyond-line-of-sight (BLOS) links using satellite communications, supported by national and international standards, are required for integrated UAS operations. The National Aeronautics and Space Administration (NASA) has undertaken an extensive technology development and test program in order to provide the required technical data needed to enable C2 standards development. NASAs UAS Integration in the National Airspace System (NAS), or UAS in the NAS Project, included as a major element the Command and Control Communications (C2) Subproject, based at NASAs Glenn Research Center. The successful first phase of the C2 Subproject, completed during 2012-2016, focused primarily on line-of-sight communications. Accomplishments included air-ground channel propagation characterization and modeling; CNPC prototype radio development; CNPC radio flight testing; satellite communications spectrum study and interference analysis; and development of C2 LOS communications standards development. The second phase of the C2 Subproject will focus primarily on beyond-line-of-sight communications, although a follow-on activity for terrestrial LOS communications, known as Terrestrial Extension, is also included. In addition to the terrestrial element, Phase 2 also includes technology development and testing activities for Ka-Band BLOS C2 Satellite Communications; Ku-Band BLOS C2 Satellite Communications; Ku-Band Interference and Propagation; and C-Band Satellite Communications. This paper will provide brief overviews of the C2 Subproject and its Phase I accomplishments, followed by a description of the plans for the C2 Subproject Phase 2.

Communications for UAS Integration in the NAS Phase 2 - Satellite Communications and Terrestrial Extension

NASA Technical Reports Server (NTRS)

Griner, James H.; Kerczewski, Robert J.

2017-01-01

In order to provide for the safe integration of unmanned aircraft systems (UAS) into the National Airspace System, the command and control communications link connecting the ground-based pilot with the unmanned aircraft must be highly reliable and robust, with national and international standards to enable interoperability and certification. Both line-of-sight (LOS) links using terrestrial-based communications and beyond-line-of-sight (BLOS) links using satellite communications, supported by national and international standards, are required for integrated UAS operations. The National Aeronautics and Space Administration (NASA) has undertaken an extensive technology development and test program in order to provide the required technical data needed to enable C2 standards development. NASAs UAS Integration in the National Airspace System (NAS), or UAS in the NAS Project, included as a major element the Command and Control Communications (C2) Subproject, based at NASAs Glenn Research Center. The successful first phase of the C2 Subproject, completed during 2012-2016, focused primarily on line-of-sight communications. Accomplishments included air-ground channel propagation characterization and modeling; CNPC prototype radio development; CNPC radio flight testing; satellite communications spectrum study and interference analysis; and development of C2 LOS communications standards development. The second phase of the C2 Subproject will focus primarily on beyond-line-of-sight communications, although a follow-on activity for terrestrial LOS communications, known as Terrestrial Extension, is also included. In addition to the terrestrial element, Phase 2 also includes technology development and testing activities for Ka-Band BLOS C2 Satellite Communications; Ku-Band BLOS C2 Satellite Communications; Ku-Band Interference and Propagation; and C-Band Satellite Communications. This paper will provide brief overviews of the C2 Subproject and its Phase I accomplishments, followed by a description of the plans for the C2 Subproject Phase 2.

78 FR 52128 - Cotton Classing, Testing and Standards: Notice of Request for an Extension and Revision to a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-22

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [AMS-CN-13-0044] Cotton Classing, Testing..., for an extension and revision to the currently approved information collection entitled Cotton... proposal to: Shethir M. Riva, Chief, Research and Promotion Staff, Cotton and Tobacco Programs, AMS, USDA...

78 FR 5430 - Extension of Approval Period for Certain Tests Used in the National Reporting System for Adult...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-25

... DEPARTMENT OF EDUCATION Extension of Approval Period for Certain Tests Used in the National Reporting System for Adult Education AGENCY: Office of Vocational and Adult Education, Department of... National Reporting System for Adult Education (NRS regulations) (73 FR 2306). The NRS regulations...

76 FR 19902 - Energy Conservation Program for Consumer Products: Decision and Order Granting 180-Day Extension...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... for Residential Furnaces and Boilers Test Procedure Amendments; Correction AGENCY: Office of Energy..., 2011), a 180-day extension of the compliance date for recent amendments to the DOE test procedure for... DOE received this petition well after February 17, 2011, the Department believes a number of factors...

Sourcebook of locations of geophysical surveys in tunnels and horizontal holes, including results of seismic refraction surveys, Rainier Mesa, Aqueduct Mesa, and Area 16, Nevada Test Site

USGS Publications Warehouse

Carroll, R.D.; Kibler, J.E.

1983-01-01

Seismic refraction surveys have been obtained sporadically in tunnels in zeolitized tuff at the Nevada Test Site since the late 1950's. Commencing in 1967 and continuing to date (1982), .extensive measurements of shear- and compressional-wave velocities have been made in five tunnel complexes in Rainier and Aqueduct Mesas and in one tunnel complex in Shoshone Mountain. The results of these surveys to 1980 are compiled in this report. In addition, extensive horizontal drilling was initiated in 1967 in connection with geologic exploration in these tunnel complexes for sites for nuclear weapons tests. Seismic and electrical surveys were conducted in the majority of these holes. The type and location of these tunnel and borehole surveys are indexed in this report. Synthesis of the seismic refraction data indicates a mean compressional-wave velocity near the nuclear device point (WP) of 23 tunnel events of 2,430 m/s (7,970 f/s) with a range of 1,846-2,753 m/s (6,060-9,030 f/s). The mean shear-wave velocity of 17 tunnel events is 1,276 m/s (4,190 f/s) with a range of 1,140-1,392 m/s (3,740-4,570 f/s). Experience indicates that these velocity variations are due chiefly to the extent of fracturing and (or) the presence of partially saturated rock in the region of the survey.

Correlation between mobility assessed by the Modified Rivermead Mobility Index and physical function in stroke patients

PubMed Central

Park, Gi-Tae; Kim, Mihyun

2016-01-01

[Purpose] The purpose of this study was to investigate the relationship between mobility assessed by the Modified Rivermead Mobility Index and variables associated with physical function in stroke patients. [Subjects and Methods] One hundred stroke patients (35 males and 65 females; age 58.60 ± 13.91 years) participated in this study. Modified Rivermead Mobility Index, muscle strength (manual muscle test), muscle tone (Modified Ashworth Scale), range of motion of lower extremity, sensory function (light touch and proprioception tests), and coordination (heel to shin and lower-extremity motor coordination tests) were assessed. [Results] The Modified Rivermead Mobility Index was correlated with all the physical function variables assessed, except the degree of knee extension. In addition, stepwise linear regression analysis revealed that coordination (heel to shin test) was the explanatory variable closely associated with mobility in stroke patients. [Conclusion] The Modified Rivermead Mobility Index score was significantly correlated with all the physical function variables. Coordination (heel to shin test) was closely related to mobility function. These results may be useful in developing rehabilitation programs for stroke patients. PMID:27630440

30 CFR 27.11 - Extension of certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Extension of certification. 27.11 Section 27.11 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS METHANE-MONITORING SYSTEMS General Provisions § 27.11 Extension of...

30 CFR 27.11 - Extension of certification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Extension of certification. 27.11 Section 27.11 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS METHANE-MONITORING SYSTEMS General Provisions § 27.11 Extension of...

American grandparents providing extensive child care to their grandchildren: prevalence and profile.

PubMed

Fuller-Thomson, E; Minkler, M

2001-04-01

This study sought to determine the prevalence and profile of grandparents providing extensive care for a grandchild (grandparents who provide 30+ hours per week or 90+ nights per year of child care, yet are not the primary caregiver of the grandchild). Secondary analysis of the 3,260 grandparent respondents in the 1992-94 National Survey of Families and Households (NSFH). Extensively caregiving grandparents were compared with custodial grandparents (those with primary responsibility for raising a grandchild for 6+ months), noncaregivers, occasional caregivers (<10 hours per week), and intermediate caregivers using chi-square tests, one-way analysis of variance tests, and logistic regression analyses. Close to 7% of all grandparents provided extensive caregiving, as did 14.9% of those who had provided any grandchild care in the last month. Extensive caregivers most closely resembled custodial caregivers and had least in common with those grandparents who never provided child care. Areas for future research, policy, and practice are highlighted, including the potential impact of welfare reform legislation on extensively caregiving grandparents.

Assessing forelimb function after unilateral cervical spinal cord injury: novel forelimb tasks predict lesion severity and recovery.

PubMed

Khaing, Zin Z; Geissler, Sydney A; Jiang, Shan; Milman, Brian D; Aguilar, Sandra V; Schmidt, Christine E; Schallert, Timothy

2012-02-10

Cervical spinal cord injury (cSCI) can cause devastating neurological deficits, including impairment or loss of upper limb and hand function. Recently there has been increasing interest in cervical spinal cord injury models because the majority of spinal cord injuries are at cervical levels. Here we examined spontaneous functional recovery of adult rats with either laminectomy or lateral hemisection of the cervical spinal cord at C3-C4. Behavioral tests were carried out, including the forelimb locomotor scale (FLS), a postural instability test (PIT), a pasta-handling test that has been used to assess forepaw digit function and latency to eat, forelimb use during vertical-lateral wall exploration in a cylindrical enclosure, and vibrissae-elicited forelimb placing tests. In addition, a forelimb step-alternation test was developed to assess functional recovery at 12 weeks post-injury. All tests detected cSCI-induced deficits relative to laminectomy. Interestingly, the severity of deficits in the forelimb step-alternation test was associated with more extensive spinal damage, greater impairment, and less recovery in the FLS and other tests. For the pasta-handling test we found that rats with a milder cervical injury (alternators) were more likely to use both forepaws together compared to rats with a more severe injury (non-alternators). In addition, using the PIT, we detected enhanced function of the good limb, suggesting that neural plasticity on the unaffected side of the spinal cord may have occurred to compensate for deficits in the impaired forelimb. These outcome measures should be useful for investigating neural events associated with cSCI, and for developing novel treatment strategies.

Comparative activity of silver based antimicrobial composites for urinary catheters.

PubMed

Thokala, Nikhil; Kealey, Carmel; Kennedy, James; Brady, Damien B; Farrell, Joseph

2018-04-04

Biomedical polymers are an integral component in a wide range of medical device designs due to their range of desirable properties. However, extensive use of polymer materials in medical devices have also been associated with an increasing incidence of patient infections. Efforts to address this issue have included the incorporation of antimicrobial additives for developing novel antimicrobial polymeric materials. Silver with its high toxicity towards bacteria, oligodynamic effect and good thermal stability has been employed as an additive for polymeric medical devices. In the present study, commercially available elemental (Biogate) and ionic (Ultrafresh 16) silver additives were incorporated into a Polyamide 11 (PA 11) matrix using a compression press. These polymer composites were evaluated for their antimicrobial and ion release properties. Elemental silver composites were determined to retain their antimicrobial properties for extended periods and actively release silver ions for 84 days; whereas the ionic silver composites lost their ion release activity and therefore antibacterial activity after 56 days. Bacterial log reduction units of 3.87 for ionic silver and 2.41 for elemental silver was identified within 24 hr, when tested in accordance with ISO 22196 test standard; indicating that ionic silver is more efficient for short-term applications compared to elemental silver. Copyright © 2018 Elsevier Ltd. All rights reserved.

Combining facial dynamics with appearance for age estimation.

PubMed

Dibeklioglu, Hamdi; Alnajar, Fares; Ali Salah, Albert; Gevers, Theo

2015-06-01

Estimating the age of a human from the captured images of his/her face is a challenging problem. In general, the existing approaches to this problem use appearance features only. In this paper, we show that in addition to appearance information, facial dynamics can be leveraged in age estimation. We propose a method to extract and use dynamic features for age estimation, using a person's smile. Our approach is tested on a large, gender-balanced database with 400 subjects, with an age range between 8 and 76. In addition, we introduce a new database on posed disgust expressions with 324 subjects in the same age range, and evaluate the reliability of the proposed approach when used with another expression. State-of-the-art appearance-based age estimation methods from the literature are implemented as baseline. We demonstrate that for each of these methods, the addition of the proposed dynamic features results in statistically significant improvement. We further propose a novel hierarchical age estimation architecture based on adaptive age grouping. We test our approach extensively, including an exploration of spontaneous versus posed smile dynamics, and gender-specific age estimation. We show that using spontaneity information reduces the mean absolute error by up to 21%, advancing the state of the art for facial age estimation.

New functional pavements for pedestrians and cyclists.

PubMed

Wallqvist, V; Kjell, G; Cupina, E; Kraft, L; Deck, C; Willinger, R

2017-08-01

When many fields of pedestrian and cyclist safety have been extensively studied, the surfacing has long been left unquestioned, despite being developed for another mode of transport and being one of the main causes for falls and fall injuries. In this project new surfacing materials for pedestrian and cyclist safety have been produced. Focusing on augmenting previously largely disregarded parameters as impact absorption, comfort and visibility at the same time as avoiding deteriorating of crucial parameters as friction and wear resistance. Rubber content, binder type, and pigment addition have been varied and evaluated. The results demonstrate that by increasing rubber content of the mixtures the head injury criterion (HIC) value and injury risk can be decreased while maintaining frictional properties according to existing criteria. Assembly of test-lanes demonstrate that some developed materials experience lower flow and component separation than standard materials due to rubber addition, calling for further optimisation of construction procedure linked to content development. Initial trials on the test-lanes indicate that a polyurethane (PU) based material has high cycling comfort, visibility and can be modified with phosphorescence properties. For standard asphalt, impact absorption might be inflicted by modification of bitumen alone but is mostly augmented by rubber addition. The results also indicate that rubber content can decrease ice formation on the materials. Copyright © 2016 Elsevier Ltd. All rights reserved.

TU-D-201-05: Validation of Treatment Planning Dose Calculations: Experience Working with MPPG 5.a

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xue, J; Park, J; Kim, L

2016-06-15

Purpose: Newly published medical physics practice guideline (MPPG 5.a.) has set the minimum requirements for commissioning and QA of treatment planning dose calculations. We present our experience in the validation of a commercial treatment planning system based on MPPG 5.a. Methods: In addition to tests traditionally performed to commission a model-based dose calculation algorithm, extensive tests were carried out at short and extended SSDs, various depths, oblique gantry angles and off-axis conditions to verify the robustness and limitations of a dose calculation algorithm. A comparison between measured and calculated dose was performed based on validation tests and evaluation criteria recommendedmore » by MPPG 5.a. An ion chamber was used for the measurement of dose at points of interest, and diodes were used for photon IMRT/VMAT validations. Dose profiles were measured with a three-dimensional scanning system and calculated in the TPS using a virtual water phantom. Results: Calculated and measured absolute dose profiles were compared at each specified SSD and depth for open fields. The disagreement is easily identifiable with the difference curve. Subtle discrepancy has revealed the limitation of the measurement, e.g., a spike at the high dose region and an asymmetrical penumbra observed on the tests with an oblique MLC beam. The excellent results we had (> 98% pass rate on 3%/3mm gamma index) on the end-to-end tests for both IMRT and VMAT are attributed to the quality beam data and the good understanding of the modeling. The limitation of the model and the uncertainty of measurement were considered when comparing the results. Conclusion: The extensive tests recommended by the MPPG encourage us to understand the accuracy and limitations of a dose algorithm as well as the uncertainty of measurement. Our experience has shown how the suggested tests can be performed effectively to validate dose calculation models.« less

Modification of the contact surfaces for improving the puncture resistance of laminar structures.

PubMed

Wang, Pengfei; Yang, Jinglei; Li, Xin; Liu, Mao; Zhang, Xin; Sun, Dawei; Bao, Chenlu; Gao, Guangfa; Yahya, Mohd Yazid; Xu, Songlin

2017-07-26

Uncovering energy absorption and surface effects of various penetrating velocities on laminar structures is essential for designing protective structures. In this study, both quasi-static and dynamic penetration tests were systematical conducted on the front surfaces of metal sheets coated with a graphene oxide (GO) solution and other media. The addition of a GO fluid film to the front impact surface aided in increasing the penetration strength, improving the failure extension and dissipating additional energy under a wide-range of indentation velocity, from 3.33 × 10 -5  m/s to 4.42 m/s. The coated -surfaces improved the specific energy dissipation by approximately 15~40% relative to the dry-contact configuration for both single-layer and double-layer configurations, and specific energy dissipations of double-layer configurations were 20~30% higher than those of the single-layer configurations. This treatment provides a facile strategy in changing the contact state for improving the failure load and dissipate additional energy.

Block Copolymer-Based Supramolecular Elastomers with High Extensibility and Large Stress Generation Capability

NASA Astrophysics Data System (ADS)

Noro, Atsushi; Hayashi, Mikihiro

We prepared block copolymer-based supramolecular elastomers with high extensibility and large stress generation capability. Reversible addition fragmentation chain transfer polymerizations were conducted under normal pressure and high pressure to synthesize several large molecular weight polystyrene-b-[poly(butyl acrylate)-co-polyacrylamide]-b-polystyrene (S-Ba-S) block copolymers. Tensile tests revealed that the largest S-Ba-S with middle block molecular weight of 3140k achieved a breaking elongation of over 2000% with a maximum tensile stress of 3.6 MPa and a toughness of 28 MJ/m3 while the reference sample without any middle block hydrogen bonds, polystyrene-b-poly(butyl acrylate)-b-polystyrene with almost the same molecular weight, was merely viscous and not self-standing. Hence, incorporation of hydrogen bonds into a long soft middle block was found to be beneficial to attain high extensibility and large stress generation capability probably due to concerted combination of entropic changes and internal potential energy changes originaing from the dissociation of multiple hydrogen bonds by elongation. This work was supported by JSPS KAKENHI Grant Numbers 13J02357, 24685035, 15K13785, and 23655213 for M.H. and A.N. A.N. also expresses his gratitude for Tanaka Rubber Science & Technology Award by Enokagaku-Shinko Foundation, Japan.

MPLM On-Orbit Interface Dynamic Flexibility Modal Test

NASA Technical Reports Server (NTRS)

Bookout, Paul S.; Rodriguez, Pedro I.; Tinson, Ian; Fleming, Paolo

2001-01-01

Now that the International Space Station (ISS) is being constructed, payload developers have to not only verify the Shuttle-to-payload interface, but also the interfaces their payload will have with the ISS. The Multi Purpose Logistic Module (MPLM) being designed and built by Alenia Spazio in Torino, Italy is one such payload. The MPLM is the primary carrier for the ISS Payload Racks, Re-supply Stowage Racks, and the Resupply Stowage Platforms to re-supply the ISS with food, water, experiments, maintenance equipment and etc. During the development of the MPLM there was no requirement for verification of the on-orbit interfaces with the ISS. When this oversight was discovered, all the dynamic test stands had already been disassembled. A method was needed that would not require an extensive testing stand and could be completed in a short amount of time. The residual flexibility testing technique was chosen. The residual flexibility modal testing method consists of measuring the free-free natural frequencies and mode shapes along with the interface frequency response functions (FRF's). Analytically, the residual flexibility method has been investigated in detail by, MacNeal, Martinez, Carne, and Miller, and Rubin, but has not been implemented extensively for model correlation due to difficulties in data acquisition. In recent years improvement of data acquisition equipment has made possible the implementation of the residual flexibility method as in Admire, Tinker, and Ivey, and Klosterman and Lemon. The residual flexibility modal testing technique is applicable to a structure with distinct points (DOF) of contact with its environment, such as the MPLM-to-Station interface through the Common Berthing Mechanism (CBM). The CBM is bolted to a flange on the forward cone of the MPLM. During the fixed base test (to verify Shuttle interfaces) some data was gathered on the forward cone panels. Even though there was some data on the forward cones, an additional modal test was performed to better characterize its behavior. The CBM mounting flange is the only remaining structure of the MPLM that no test data was available. This paper discusses the implementation of the residual flexibility modal testing technique on the CBM flange and the modal test of the forward cone panels.

Utility of an interferon-gamma release assay for latent tuberculosis diagnosis in a case of bullous pemphigoid.

PubMed

Goodfellow, Alfred; Keeling, Douglas N; Hayes, Robert C; Webster, Duncan

2009-01-01

With increasing use of immunosuppressive therapy, including tumor necrosis factor alpha inhibitors, there is concern about infectious complications, including reactivation of latent Mycobacterium tuberculosis infection. Routine testing prior to administration of systemic immunosuppression includes the tuberculin skin test, which lacks sensitivity and specificity and may be difficult to interpret in the presence of extensive cutaneous disease. Treatment of individuals with latent tuberculosis infection is recommended when immunosuppressive medications are to be employed. We report a case in which a diagnosis of latent tuberculosis infection in a patient with extensive bullous pemphigoid was clarified by the use of an interferon-gamma release assay after equivocal tuberculin skin test results. Interferon-gamma release assays are useful adjuncts to the tuberculin skin test in the diagnosis of latent tuberculosis infection in the setting of extensive cutaneous disease.

Stabilizing potential of anterior, posterior, and circumferential fixation for multilevel cervical arthrodesis: an in vitro human cadaveric study of the operative and adjacent segment kinematics.

PubMed

Dmitriev, Anton E; Kuklo, Timothy R; Lehman, Ronald A; Rosner, Michael K

2007-03-15

This is an in vitro biomechanical study. The current investigation was performed to evaluate the stabilizing potential of anterior, posterior, and circumferential cervical fixation on operative and adjacent segment motion following 2 and 3-level reconstructions. Previous studies reported increases in adjacent level range of motion (ROM) and intradiscal pressure following single-level cervical arthrodesis; however, no studies have compared adjacent level effects following multilevel anterior versus posterior reconstructions. Ten human cadaveric cervical spines were biomechanically tested using an unconstrained spine simulator under axial rotation, flexion-extension, and lateral bending loading. After intact analysis, all specimens were sequentially instrumented from C3 to C5 with: (1) lateral mass fixation, (2) anterior cervical plate with interbody cages, and (3) combined anterior and posterior fixation. Following biomechanical analysis of 2-level constructs, fixation was extended to C6 and testing repeated. Full ROM was monitored at the operative and adjacent levels, and data normalized to the intact (100%). All reconstructive methods reduced operative level ROM relative to intact specimens under all loading methods (P < 0.05). However, circumferential fixation provided the greatest segmental stability among 2 and 3-level constructs (P < 0.05). Moreover, anterior cervical plate fixation was least efficient at stabilizing operative segments following C3-C6 arthrodesis (P < 0.05). Supradjacent ROM was increased for all treatment groups compared to normal data during flexion-extension testing (P < 0.05). Similar trends were observed under axial rotation and lateral bending loading. At the distal level, flexion-extension and axial rotation testing revealed comparable intergroup differences (P < 0.05), while lateral bending loading indicated greater ROM following 2-level circumferential fixation (P < 0.05). Results from our study revealed greater adjacent level motion following all 3 fixation types. No consistent significant intergroup differences in neighboring segment kinematics were detected among reconstructions. Circumferential fixation provided the greatest level of segmental stability without additional significant increase in adjacent level ROM.

Space Fission Propulsion Testing and Development Progress. Phase 1

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Houts, Mike; Pedersen, Kevin; Godfroy, Tom; Dickens, Ricky; Poston, David; Reid, Bob; Salvail, Pat; Ring, Peter; Rodgers, Stephen L. (Technical Monitor)

2001-01-01

Successful development of space fission systems will require an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. Testing can be divided into two categories, non-nuclear tests and nuclear tests. Full power nuclear tests of space fission systems we expensive, time consuming, and of limited use, even in the best of programmatic environments. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system performance and lifetime can be attained through a series of non-nuclear tests. Non-nuclear tests are affordable and timely, and the cause of component and system failures can be quickly and accurately identified. MSFC is leading a Safe Affordable Fission Engine (SAFE) test series whose ultimate goal is the demonstration of a 300 kW flight configuration system using non-nuclear testing. This test series is carried out in collaboration with other NASA centers, other government agencies, industry, and universities. If SAFE-related nuclear tests are desired they will have a high probability of success and can be performed at existing nuclear facilities. The paper describes the SAFE non-nuclear test series, which includes test article descriptions, test results and conclusions, and future test plans.

Phase 1 space fission propulsion system testing and development progress

NASA Astrophysics Data System (ADS)

van Dyke, Melissa; Houts, Mike; Pedersen, Kevin; Godfroy, Tom; Dickens, Ricky; Poston, David; Reid, Bob; Salvail, Pat; Ring, Peter

2001-02-01

Successful development of space fission systems will require an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. Testing can be divided into two categories, non-nuclear tests and nuclear tests. Full power nuclear tests of space fission systems are expensive, time consuming, and of limited use, even in the best of programmatic environments. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system performance and lifetime can be attained through a series of non-nuclear tests. Non-nuclear tests are affordable and timely, and the cause of component and system failures can be quickly and accurately identified, MSFC is leading a Safe Affordable Fission Engine (SAFE) test series whose ultimate goal is the demonstration of a 300 kW flight configuration system using non-nuclear testing. This test series is carried out in collaboration with other NASA centers, other government agencies, industry, and universities. If SAFE-related nuclear tests are desired, they will have a high probability of success and can be performed at existing nuclear facilities. The paper describes the SAFE non-nuclear test series, which includes test article descriptions, test results and conclusions, and future test plans. .

78 FR 34974 - Request for Extension and Revision of a Currently Approved Information Collection With Additional...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... Collection With Additional Merge of Additional Collection: Regulations Governing Inspection and Certification of Fresh and Processed Fruits, Vegetables and other Products AGENCY: Agricultural Marketing Service... Additional Merge of Additional Collection: Regulations Governing Inspection and Certification of Fresh and...

20 CFR 416.1232 - Replacement of lost, damaged, or stolen excluded resources.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Exception: For victims of Hurricane Andrew only, the extension period for good cause may be extended for up... additional extension under the Hurricane Andrew provision) may be extended for a reasonable period up to an...

20 CFR 416.1232 - Replacement of lost, damaged, or stolen excluded resources.

Code of Federal Regulations, 2014 CFR

2014-04-01

.... Exception: For victims of Hurricane Andrew only, the extension period for good cause may be extended for up... additional extension under the Hurricane Andrew provision) may be extended for a reasonable period up to an...

20 CFR 416.1232 - Replacement of lost, damaged, or stolen excluded resources.

Code of Federal Regulations, 2013 CFR

2013-04-01

.... Exception: For victims of Hurricane Andrew only, the extension period for good cause may be extended for up... additional extension under the Hurricane Andrew provision) may be extended for a reasonable period up to an...

20 CFR 416.1232 - Replacement of lost, damaged, or stolen excluded resources.

Code of Federal Regulations, 2011 CFR

2011-04-01

.... Exception: For victims of Hurricane Andrew only, the extension period for good cause may be extended for up... additional extension under the Hurricane Andrew provision) may be extended for a reasonable period up to an...

20 CFR 416.1232 - Replacement of lost, damaged, or stolen excluded resources.

Code of Federal Regulations, 2012 CFR

2012-04-01

.... Exception: For victims of Hurricane Andrew only, the extension period for good cause may be extended for up... additional extension under the Hurricane Andrew provision) may be extended for a reasonable period up to an...

Effect of cellulase, xylanase and α-amylase combinations on the rheological properties of Chinese steamed bread dough enriched in wheat bran.

PubMed

Liu, Wenjun; Brennan, Margaret Anne; Serventi, Luca; Brennan, Charles Stephen

2017-11-01

The present study investigates the effects of α-amylase (6 and 10ppm), xylanase (70 and 120ppm) and cellulase (35 and 60ppm) on the rheological properties of bread dough. The mixing property of dough was measured by using a DoughLAB. The extension and stickiness of dough were analysed using the Texture Analyzer. The results illustrate that the addition of single enzyme and enzyme combinations can increase the extensibility, softening, mixing tolerance index (MTI) and stickiness, whereas decrease the resistance to extension. For water absorption, the addition of single enzyme had no significant effect, while the combination enzyme significantly (p<0.05) decreased the values from 63.9 to 59.6% (wheat flour dough) and 71.4-67.1% (dough incorporated with 15% wheat bran). Compared to the single enzyme with the value of 34.1mm, enzyme combination (6, 120 and 60ppm) increased the extensibility of wheat flour dough by up to 42%. Additionally, combination of α-amylase, xylanase and cellulase had a synergetic effect on the dough rheology. Copyright © 2017 Elsevier Ltd. All rights reserved.

Positioning, Splinting, and Contracture Management

DTIC Science & Technology

2011-01-01

IP) joints in extension, thumb in palmar abduction, hip extension and abducted 20 (no external rotation), knee extension, and neutral ankle ...to skin breakdown are the heels,55 sacrum, ankles , wrists, elbows, and occipital area.8 Some options for splinting and positioning devices can be...children.70 In addition, moveable parts are difficult to anchor to small levers and the cognition and responsibilities needed for proper fit of dynamic

Nuclear Thermal Rocket Element Environmental Simulator (NTREES) Upgrade Activities

NASA Technical Reports Server (NTRS)

Emrich, William J., Jr.

2014-01-01

Over the past year the Nuclear Thermal Rocket Element Environmental Simulator (NTREES) has been undergoing a significant upgrade beyond its initial configuration. The NTREES facility is designed to perform realistic non-nuclear testing of nuclear thermal rocket (NTR) fuel elements and fuel materials. Although the NTREES facility cannot mimic the neutron and gamma environment of an operating NTR, it can simulate the thermal hydraulic environment within an NTR fuel element to provide critical information on material performance and compatibility. The first phase of the upgrade activities which was completed in 2012 in part consisted of an extensive modification to the hydrogen system to permit computer controlled operations outside the building through the use of pneumatically operated variable position valves. This setup also allows the hydrogen flow rate to be increased to over 200 g/sec and reduced the operation complexity of the system. The second stage of modifications to NTREES which has just been completed expands the capabilities of the facility significantly. In particular, the previous 50 kW induction power supply has been replaced with a 1.2 MW unit which should allow more prototypical fuel element temperatures to be reached. The water cooling system was also upgraded to so as to be capable of removing 100% of the heat generated during. This new setup required that the NTREES vessel be raised onto a platform along with most of its associated gas and vent lines. In this arrangement, the induction heater and water systems are now located underneath the platform. In this new configuration, the 1.2 MW NTREES induction heater will be capable of testing fuel elements and fuel materials in flowing hydrogen at pressures up to 1000 psi at temperatures up to and beyond 3000 K and at near-prototypic reactor channel power densities. NTREES is also capable of testing potential fuel elements with a variety of propellants, including hydrogen with additives to inhibit corrosion of certain potential NTR fuel forms. Additional diagnostic upgrades included in the present NTREES set up include the addition of a gamma ray spectrometer located near the vent filter to detect uranium fuel particles exiting the fuel element in the propellant exhaust stream to provide additional information any material loss occurring during testing. Other aspects of the upgrade included reworking NTREES to reduce the operational complexity of the system despite the increased complexity of the induction heating system. To this end, many of the controls were consolidated on fewer panels. As part of this upgrade activity, the Safety Assessment (SA) and the Standard Operating Procedures (SOPs) for NTREES were extensively rewritten. The new 1.2 MW induction heater consists of three physical units consisting of a transformer, rectifier, and inverter. This multiunit arrangement facilitated increasing the flexibility of the induction heater by more easily allowing variable frequency operation. Frequency ranges between 20 and 60 kHz can be accommodated in the new induction heater allowing more representative power distributions to be generated within the test elements.

Effects of Deployment on Musculoskeletal and Physiological Characteristics and Balance.

PubMed

Nagai, Takashi; Abt, John P; Sell, Timothy C; Keenan, Karen A; McGrail, Mark A; Smalley, Brian W; Lephart, Scott M

2016-09-01

Despite many nonbattle injuries reported during deployment, few studies have been conducted to evaluate the effects of deployment on musculoskeletal and physiological characteristics and balance. A total of 35 active duty U.S. Army Soldiers participated in laboratory testing before and after deployment to Afghanistan. The following measures were obtained for each Soldier: shoulder, trunk, hip, knee, and ankle strength and range of motion (ROM), balance, body composition, aerobic capacity, and anaerobic power/capacity. Additionally, Soldiers were asked about their physical activity and load carriage. Paired t tests or Wilcoxon tests with an α = 0.05 set a priori were used for statistical analyses. Shoulder external rotation ROM, torso rotation ROM, ankle dorsiflexion ROM, torso rotation strength, and anaerobic power significantly increased following deployment (p < 0.05). Shoulder extension ROM, shoulder external rotation strength, and eyes-closed balance (p < 0.05) were significantly worse following deployment. The majority of Soldiers (85%) engaged in physical activity. In addition, 58% of Soldiers reported regularly carrying a load (22 kg average). The deployment-related changes in musculoskeletal and physiological characteristics and balance as well as physical activity and load carriage during deployment may assist with proper preparation with the intent to optimize tactical readiness and mitigate injury risk. Reprint & Copyright © 2016 Association of Military Surgeons of the U.S.

Modeling AFM-induced PEVK extension and the reversible unfolding of Ig/FNIII domains in single and multiple titin molecules.

PubMed Central

Zhang, B; Evans, J S

2001-01-01

Molecular elasticity is associated with a select number of polypeptides and proteins, such as titin, Lustrin A, silk fibroin, and spider silk dragline protein. In the case of titin, the globular (Ig) and non-globular (PEVK) regions act as extensible springs under stretch; however, their unfolding behavior and force extension characteristics are different. Using our time-dependent macroscopic method for simulating AFM-induced titin Ig domain unfolding and refolding, we simulate the extension and relaxation of hypothetical titin chains containing Ig domains and a PEVK region. Two different models are explored: 1) a series-linked WLC expression that treats the PEVK region as a distinct entropic spring, and 2) a summation of N single WLC expressions that simulates the extension and release of a discrete number of parallel titin chains containing constant or variable amounts of PEVK. In addition to these simulations, we also modeled the extension of a hypothetical PEVK domain using a linear Hooke's spring model to account for "enthalpic" contributions to PEVK elasticity. We find that the modified WLC simulations feature chain length compensation, Ig domain unfolding/refolding, and force-extension behavior that more closely approximate AFM, laser tweezer, and immunolocalization experimental data. In addition, our simulations reveal the following: 1) PEVK extension overlaps with the onset of Ig domain unfolding, and 2) variations in PEVK content within a titin chain ensemble lead to elastic diversity within that ensemble. PMID:11159428

From the promotion of biodiversity to the Recovery of organic waste

NASA Astrophysics Data System (ADS)

Jammoukh, Mustapha; Mansouri, Khalifa; Salhi, Bachir

2018-05-01

This article presents an empirical research to classify a new renewable resource material, as opposed to eco-composites, it has been neglected by the materials specialist. This classification is based on the typology of elastic behavior demonstrated by tensile tests. In addition, some identifying criterions of the usefulness of this material were examined. To justify the relevance of this classification, curves from the extension of tests focusing on the virgin material, illustrate significant results of the review. Obtained from waste, having a significant recycling possibilities and potential from renewable resources, bio-mechanically characterized loads will be injected into polymeric materials of different categories. All in the perspective of promoting changes in thermomechanical properties, whether static or dynamic; such as resistance to corrosion, heat, wear… They result in functional changes such as security, relief, coatings and stability…

Novel Hybrid Adaptive Controller for Manipulation in Complex Perturbation Environments

PubMed Central

Smith, Alex M. C.; Yang, Chenguang; Ma, Hongbin; Culverhouse, Phil; Cangelosi, Angelo; Burdet, Etienne

2015-01-01

In this paper we present a hybrid control scheme, combining the advantages of task-space and joint-space control. The controller is based on a human-like adaptive design, which minimises both control effort and tracking error. Our novel hybrid adaptive controller has been tested in extensive simulations, in a scenario where a Baxter robot manipulator is affected by external disturbances in the form of interaction with the environment and tool-like end-effector perturbations. The results demonstrated improved performance in the hybrid controller over both of its component parts. In addition, we introduce a novel method for online adaptation of learning parameters, using the fuzzy control formalism to utilise expert knowledge from the experimenter. This mechanism of meta-learning induces further improvement in performance and avoids the need for tuning through trial testing. PMID:26029916

CardioGuard: A Brassiere-Based Reliable ECG Monitoring Sensor System for Supporting Daily Smartphone Healthcare Applications

PubMed Central

Kwon, Sungjun; Kim, Jeehoon; Kang, Seungwoo; Lee, Youngki; Baek, Hyunjae

2014-01-01

Abstract We propose CardioGuard, a brassiere-based reliable electrocardiogram (ECG) monitoring sensor system, for supporting daily smartphone healthcare applications. It is designed to satisfy two key requirements for user-unobtrusive daily ECG monitoring: reliability of ECG sensing and usability of the sensor. The system is validated through extensive evaluations. The evaluation results showed that the CardioGuard sensor reliably measure the ECG during 12 representative daily activities including diverse movement levels; 89.53% of QRS peaks were detected on average. The questionnaire-based user study with 15 participants showed that the CardioGuard sensor was comfortable and unobtrusive. Additionally, the signal-to-noise ratio test and the washing durability test were conducted to show the high-quality sensing of the proposed sensor and its physical durability in practical use, respectively. PMID:25405527

Architecture Design and Experimental Platform Demonstration of Optical Network based on OpenFlow Protocol

NASA Astrophysics Data System (ADS)

Xing, Fangyuan; Wang, Honghuan; Yin, Hongxi; Li, Ming; Luo, Shenzi; Wu, Chenguang

2016-02-01

With the extensive application of cloud computing and data centres, as well as the constantly emerging services, the big data with the burst characteristic has brought huge challenges to optical networks. Consequently, the software defined optical network (SDON) that combines optical networks with software defined network (SDN), has attracted much attention. In this paper, an OpenFlow-enabled optical node employed in optical cross-connect (OXC) and reconfigurable optical add/drop multiplexer (ROADM), is proposed. An open source OpenFlow controller is extended on routing strategies. In addition, the experiment platform based on OpenFlow protocol for software defined optical network, is designed. The feasibility and availability of the OpenFlow-enabled optical nodes and the extended OpenFlow controller are validated by the connectivity test, protection switching and load balancing experiments in this test platform.

Stochastic model of cell rearrangements in convergent extension of ascidian notochord

NASA Astrophysics Data System (ADS)

Lubkin, Sharon; Backes, Tracy; Latterman, Russell; Small, Stephen

2007-03-01

We present a discrete stochastic cell based model of convergent extension of the ascidian notochord. Our work derives from research that clarifies the coupling of invagination and convergent extension in ascidian notochord morphogenesis (Odell and Munro, 2002). We have tested the roles of cell-cell adhesion, cell-extracellular matrix adhesion, random motion, and extension of individual cells, as well as the presence or absence of various tissue types, and determined which factors are necessary and/or sufficient for convergent extension.

77 FR 67655 - Agency Information Collection Activities; Proposed Collection; Comment Request; Food Additive...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-13

...] Agency Information Collection Activities; Proposed Collection; Comment Request; Food Additive Petitions and Investigational Food Additive Exemptions; Extension AGENCY: Food and Drug Administration, HHS... solicits comments on food additive petitions regarding animal food. DATES: Submit electronic or written...

Testing a New Generation: Implementing Clickers as an Extension Data Collection Tool

ERIC Educational Resources Information Center

Parmer, Sondra M.; Parmer, Greg; Struempler, Barb

2012-01-01

Using clickers to gauge student understanding in large classrooms is well documented. Less well known is the effectiveness of using clickers with youth for test taking in large-scale Extension programs. This article describes the benefits and challenges of collecting evaluation data using clickers with a third-grade population participating in a…

76 FR 24034 - Determination of Regulatory Review Period for Purposes of Patent Extension; CONVENIA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... periods of time: A testing phase and an approval phase. For animal drug products, the testing phase begins... and Trademarks, Department of Commerce, for the extension of a patent which claims that animal drug... Animal Drug and Patent Term Restoration Act (Pub. L. 100-670) generally provide that a patent may be...

A Meta-Analysis of Extensive Reading Research

ERIC Educational Resources Information Center

Nakanishi, Takayuki

2015-01-01

The purposes of this study were to investigate the overall effectiveness of extensive reading, whether learners' age impacts learning, and whether the length of time second language learners engage in extensive reading influences test scores. The author conducted a meta-analysis to answer research questions and to identify future research…

Investigation of microstructure in additive manufactured Inconel 625 by spatially resolved neutron transmission spectroscopy

DOE PAGES

Tremsin, Anton S.; Gao, Yan; Dial, Laura C.; ...

2016-07-08

Non-destructive testing techniques based on neutron imaging and diffraction can provide information on the internal structure of relatively thick metal samples (up to several cm), which are opaque to other conventional non-destructive methods. Spatially resolved neutron transmission spectroscopy is an extension of traditional neutron radiography, where multiple images are acquired simultaneously, each corresponding to a narrow range of energy. The analysis of transmission spectra enables studies of bulk microstructures at the spatial resolution comparable to the detector pixel. In this study we demonstrate the possibility of imaging (with ~100 μm resolution) distribution of some microstructure properties, such as residual strain,more » texture, voids and impurities in Inconel 625 samples manufactured with an additive manufacturing method called direct metal laser melting (DMLM). Although this imaging technique can be implemented only in a few large-scale facilities, it can be a valuable tool for optimization of additive manufacturing techniques and materials and for correlating bulk microstructure properties to manufacturing process parameters. Additionally, the experimental strain distribution can help validate finite element models which many industries use to predict the residual stress distributions in additive manufactured components.« less

Investigation of microstructure in additive manufactured Inconel 625 by spatially resolved neutron transmission spectroscopy.

PubMed

Tremsin, Anton S; Gao, Yan; Dial, Laura C; Grazzi, Francesco; Shinohara, Takenao

2016-01-01

Non-destructive testing techniques based on neutron imaging and diffraction can provide information on the internal structure of relatively thick metal samples (up to several cm), which are opaque to other conventional non-destructive methods. Spatially resolved neutron transmission spectroscopy is an extension of traditional neutron radiography, where multiple images are acquired simultaneously, each corresponding to a narrow range of energy. The analysis of transmission spectra enables studies of bulk microstructures at the spatial resolution comparable to the detector pixel. In this study we demonstrate the possibility of imaging (with ~100 μm resolution) distribution of some microstructure properties, such as residual strain, texture, voids and impurities in Inconel 625 samples manufactured with an additive manufacturing method called direct metal laser melting (DMLM). Although this imaging technique can be implemented only in a few large-scale facilities, it can be a valuable tool for optimization of additive manufacturing techniques and materials and for correlating bulk microstructure properties to manufacturing process parameters. In addition, the experimental strain distribution can help validate finite element models which many industries use to predict the residual stress distributions in additive manufactured components.

Investigation of microstructure in additive manufactured Inconel 625 by spatially resolved neutron transmission spectroscopy

NASA Astrophysics Data System (ADS)

Tremsin, Anton S.; Gao, Yan; Dial, Laura C.; Grazzi, Francesco; Shinohara, Takenao

2016-01-01

Non-destructive testing techniques based on neutron imaging and diffraction can provide information on the internal structure of relatively thick metal samples (up to several cm), which are opaque to other conventional non-destructive methods. Spatially resolved neutron transmission spectroscopy is an extension of traditional neutron radiography, where multiple images are acquired simultaneously, each corresponding to a narrow range of energy. The analysis of transmission spectra enables studies of bulk microstructures at the spatial resolution comparable to the detector pixel. In this study we demonstrate the possibility of imaging (with 100 μm resolution) distribution of some microstructure properties, such as residual strain, texture, voids and impurities in Inconel 625 samples manufactured with an additive manufacturing method called direct metal laser melting (DMLM). Although this imaging technique can be implemented only in a few large-scale facilities, it can be a valuable tool for optimization of additive manufacturing techniques and materials and for correlating bulk microstructure properties to manufacturing process parameters. In addition, the experimental strain distribution can help validate finite element models which many industries use to predict the residual stress distributions in additive manufactured components.

Investigation of microstructure in additive manufactured Inconel 625 by spatially resolved neutron transmission spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tremsin, Anton S.; Gao, Yan; Dial, Laura C.

Non-destructive testing techniques based on neutron imaging and diffraction can provide information on the internal structure of relatively thick metal samples (up to several cm), which are opaque to other conventional non-destructive methods. Spatially resolved neutron transmission spectroscopy is an extension of traditional neutron radiography, where multiple images are acquired simultaneously, each corresponding to a narrow range of energy. The analysis of transmission spectra enables studies of bulk microstructures at the spatial resolution comparable to the detector pixel. In this study we demonstrate the possibility of imaging (with ~100 μm resolution) distribution of some microstructure properties, such as residual strain,more » texture, voids and impurities in Inconel 625 samples manufactured with an additive manufacturing method called direct metal laser melting (DMLM). Although this imaging technique can be implemented only in a few large-scale facilities, it can be a valuable tool for optimization of additive manufacturing techniques and materials and for correlating bulk microstructure properties to manufacturing process parameters. Additionally, the experimental strain distribution can help validate finite element models which many industries use to predict the residual stress distributions in additive manufactured components.« less

Investigation of microstructure in additive manufactured Inconel 625 by spatially resolved neutron transmission spectroscopy

PubMed Central

Tremsin, Anton S.; Gao, Yan; Dial, Laura C.; Grazzi, Francesco; Shinohara, Takenao

2016-01-01

Abstract Non-destructive testing techniques based on neutron imaging and diffraction can provide information on the internal structure of relatively thick metal samples (up to several cm), which are opaque to other conventional non-destructive methods. Spatially resolved neutron transmission spectroscopy is an extension of traditional neutron radiography, where multiple images are acquired simultaneously, each corresponding to a narrow range of energy. The analysis of transmission spectra enables studies of bulk microstructures at the spatial resolution comparable to the detector pixel. In this study we demonstrate the possibility of imaging (with ~100 μm resolution) distribution of some microstructure properties, such as residual strain, texture, voids and impurities in Inconel 625 samples manufactured with an additive manufacturing method called direct metal laser melting (DMLM). Although this imaging technique can be implemented only in a few large-scale facilities, it can be a valuable tool for optimization of additive manufacturing techniques and materials and for correlating bulk microstructure properties to manufacturing process parameters. In addition, the experimental strain distribution can help validate finite element models which many industries use to predict the residual stress distributions in additive manufactured components. PMID:27877885

Needle puncture in rabbit functional spinal units alters rotational biomechanics.

PubMed

Hartman, Robert A; Bell, Kevin M; Quan, Bichun; Nuzhao, Yao; Sowa, Gwendolyn A; Kang, James D

2015-04-01

An in vitro biomechanical study for rabbit lumbar functional spinal units (FSUs) using a robot-based spine testing system. To elucidate the effect of annular puncture with a 16 G needle on mechanical properties in flexion/extension, axial rotation, and lateral bending. Needle puncture of the intervertebral disk has been shown to alter mechanical properties of the disk in compression, torsion, and bending. The effect of needle puncture in FSUs, where intact spinal ligaments and facet joints may mitigate or amplify these changes in the disk, on spinal motion segment stability subject to physiological rotations remains unknown. Rabbit FSUs were tested using a robot testing system whose force/moment and position precision were assessed to demonstrate system capability. Flexibility testing methods were developed by load-to-failure testing in flexion/extension, axial rotation, and lateral bending. Subsequent testing methods were used to examine a 16 G needle disk puncture and No. 11 blade disk stab (positive control for mechanical disruption). Flexibility testing was used to assess segmental range-of-motion (degrees), neutral zone stiffness (N m/degrees) and width (degrees and N m), and elastic zone stiffness before and after annular injury. The robot-based system was capable of performing flexibility testing on FSUs-mean precision of force/moment measurements and robot system movements were <3% and 1%, respectively, of moment-rotation target values. Flexibility moment targets were 0.3 N m for flexion and axial rotation and 0.15 N m for extension and lateral bending. Needle puncture caused significant (P<0.05) changes only in flexion/extension range-of-motion and neutral zone stiffness and width (N m) compared with preintervention. No. 11 blade-stab significantly increased range-of-motion in all motions, decreased neutral zone stiffness and width (N m) in flexion/extension, and increased elastic zone stiffness in flexion and lateral bending. These findings suggest that disk puncture and stab can destabilize FSUs in primary rotations.

The Effect of Continuous Weathering on Light Metal Alloys Used in Aircraft

NASA Technical Reports Server (NTRS)

Mutchler, Willard

1939-01-01

An investigation of the corrosion of light metal alloys used in aircraft was begun at the National Bureau of Standards in 1925 and has for its purpose causes of corrosion in aluminum-rich and magnesium-rich alloys together with the development of methods for its prevention. The results, obtained in an extensive series of laboratory and weather-exposure tests, reveal the relative durability of a number of commercially available materials and the extent to which the application of various surface coatings of oxide alone and with paint coatings afforded additional protection. The paper may be considered as a supplement to NACA report 490.

On transonic flow past a wave-shaped wall

NASA Technical Reports Server (NTRS)

Kaplan, Carl

1953-01-01

This report is an extension of a previous investigation (described in NACA rep. 1069) concerned with the solution of the nonlinear differential equation for transonic flow past a wavy wall. In the present work several new notions are introduced which permit the solution of the recursion formulas arising from the method of integration in series. In addition, a novel numerical tests of convergence, applied to the power series (in transonic similarity parameter) representing the local Mach number distribution at the boundary, indicates that smooth symmetrical potential flow past the wavy wall is no longer possible once the critical value of the stream Mach number has been exceeded.

Shocks, Rarefaction Waves, and Current Fluctuations for Anharmonic Chains

DOE PAGES

Mendl, Christian B.; Spohn, Herbert

2016-10-04

The nonequilibrium dynamics of anharmonic chains is studied by imposing an initial domain-wall state, in which the two half lattices are prepared in equilibrium with distinct parameters. Here, we analyse the Riemann problem for the corresponding Euler equations and, in specific cases, compare with molecular dynamics. Additionally, the fluctuations of time-integrated currents are investigated. In analogy with the KPZ equation, their typical fluctuations should be of size t 1/3 and have a Tracy–Widom GUE distributed amplitude. The proper extension to anharmonic chains is explained and tested through molecular dynamics. Our results are calibrated against the stochastic LeRoux lattice gas.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schlanderer, Stefan C., E-mail: stefan.schlanderer@unimelb.edu.au; Weymouth, Gabriel D., E-mail: G.D.Weymouth@soton.ac.uk; Sandberg, Richard D., E-mail: richard.sandberg@unimelb.edu.au

This paper introduces a virtual boundary method for compressible viscous fluid flow that is capable of accurately representing moving bodies in flow and aeroacoustic simulations. The method is the compressible extension of the boundary data immersion method (BDIM, Maertens & Weymouth (2015), ). The BDIM equations for the compressible Navier–Stokes equations are derived and the accuracy of the method for the hydrodynamic representation of solid bodies is demonstrated with challenging test cases, including a fully turbulent boundary layer flow and a supersonic instability wave. In addition we show that the compressible BDIM is able to accurately represent noise radiation frommore » moving bodies and flow induced noise generation without any penalty in allowable time step.« less

Bias extension test on a bi-axial non-crimp fabric powdered with a non-reactive binder system

NASA Astrophysics Data System (ADS)

Pourtier, Jean; Duchamp, Boris; Kowalski, Maxime; Legrand, Xavier; Wang, Peng; Soulat, Damien

2018-05-01

In this communication, we investigated the effects of a chemical non-reactive binder system (powder) on the formability of NCF. Those influences are evaluated for two different of bi-axial NCF structures tested in a range of temperature [20°C - 140°] during bias extension tests (Fig. 1). This analyze is based on the study of force in function of deformation modes (slipping effects and shear angle field).

Validity and Reliability of a New Device (WIMU®) for Measuring Hamstring Muscle Extensibility.

PubMed

Muyor, José M

2017-09-01

The aims of the current study were 1) to evaluate the validity of the WIMU ® system for measuring hamstring muscle extensibility in the passive straight leg raise (PSLR) test using an inclinometer for the criterion and 2) to determine the test-retest reliability of the WIMU ® system to measure hamstring muscle extensibility during the PSLR test. 55 subjects were evaluated on 2 separate occasions. Data from a Unilever inclinometer and WIMU ® system were collected simultaneously. Intraclass correlation coefficients (ICCs) for the validity were very high (0.983-1); a very low systematic bias (-0.21°--0.42°), random error (0.05°-0.04°) and standard error of the estimate (0.43°-0.34°) were observed (left-right leg, respectively) between the 2 devices (inclinometer and the WIMU ® system). The R 2 between the devices was 0.999 (p<0.001) in both the left and right legs. The test-retest reliability of the WIMU ® system was excellent, with ICCs ranging from 0.972-0.995, low coefficients of variation (0.01%), and a low standard error of the estimate (0.19-0.31°). The WIMU ® system showed strong concurrent validity and excellent test-retest reliability for the evaluation of hamstring muscle extensibility in the PSLR test. © Georg Thieme Verlag KG Stuttgart · New York.

The calibration and flight test performance of the space shuttle orbiter air data system

NASA Technical Reports Server (NTRS)

Dean, A. S.; Mena, A. L.

1983-01-01

The Space Shuttle air data system (ADS) is used by the guidance, navigation and control system (GN&C) to guide the vehicle to a safe landing. In addition, postflight aerodynamic analysis requires a precise knowledge of flight conditions. Since the orbiter is essentially an unpowered vehicle, the conventional methods of obtaining the ADS calibration were not available; therefore, the calibration was derived using a unique and extensive wind tunnel test program. This test program included subsonic tests with a 0.36-scale orbiter model, transonic and supersonic tests with a smaller 0.2-scale model, and numerous ADS probe-alone tests. The wind tunnel calibration was further refined with subsonic results from the approach and landing test (ALT) program, thus producing the ADS calibration for the orbital flight test (OFT) program. The calibration of the Space Shuttle ADS and its performance during flight are discussed in this paper. A brief description of the system is followed by a discussion of the calibration methodology, and then by a review of the wind tunnel and flight test programs. Finally, the flight results are presented, including an evaluation of the system performance for on-board systems use and a description of the calibration refinements developed to provide the best possible air data for postflight analysis work.

An investigation of leg and trunk strength and reaction times of hard-style martial arts practitioners.

PubMed

Donovan, Oliver O; Cheung, Jeanette; Catley, Maria; McGregor, Alison H; Strutton, Paul H

2006-01-01

The purpose of this study was to investigate trunk and knee strength in practitioners of hard-style martial arts. An additional objective was to examine reaction times in these participants by measuring simple reaction times (SRT), choice reaction times (CRT) and movement times (MT). Thirteen high-level martial artists and twelve sedentary participants were tested under isokinetic and isometric conditions on an isokinetic dynamometer. Response and movement times were also measured in response to simple and choice auditory cues. Results indicated that the martial arts group generated a greater body-weight adjusted peak torque with both legs at all speeds during isokinetic extension and flexion, and in isometric extension but not flexion. In isokinetic and isometric trunk flexion and extension, martial artists tended to have higher peak torques than controls, but they were not significantly different (p > 0.05). During the SRT and CRT tasks the martial artists were no quicker in lifting their hand off a button in response to the stimulus [reaction time (RT)] but were significantly faster in moving to press another button [movement time (MT)]. In conclusion, the results reveal that training in a martial art increases the strength of both the flexors and extensors of the leg. Furthermore, they have faster movement times to auditory stimuli. These results are consistent with the physical aspects of the martial arts. Key PointsMartial artists undertaking hard-style martial arts have greater strength in their knee flexor and extensor muscles as tested under isokinetic testing. Under isometric testing conditions they have stronger knee extensors only.The trunk musculature is generally higher under both conditions of testing in the martial artists, although not significantly.The total reaction times of the martial artists to an auditory stimulus were significantly faster than the control participants. When analysed further it was revealed that the decrease in reaction time was due to the movement time component of the total reaction time.The training involved for the practice of the hard-style martial arts increases the strength of muscles involved in kicking. This increased strength is not seen in the trunk muscles. Furthermore, martial artists have a faster response time; the cause of which appears to be only the faster movement time.

An Investigation Of Leg And Trunk Strength And Reaction Times Of Hard-Style Martial Arts Practitioners

PubMed Central

Donovan, Oliver O; Cheung, Jeanette; Catley, Maria; McGregor, Alison H.; Strutton, Paul H.

2006-01-01

The purpose of this study was to investigate trunk and knee strength in practitioners of hard-style martial arts. An additional objective was to examine reaction times in these participants by measuring simple reaction times (SRT), choice reaction times (CRT) and movement times (MT). Thirteen high-level martial artists and twelve sedentary participants were tested under isokinetic and isometric conditions on an isokinetic dynamometer. Response and movement times were also measured in response to simple and choice auditory cues. Results indicated that the martial arts group generated a greater body-weight adjusted peak torque with both legs at all speeds during isokinetic extension and flexion, and in isometric extension but not flexion. In isokinetic and isometric trunk flexion and extension, martial artists tended to have higher peak torques than controls, but they were not significantly different (p > 0.05). During the SRT and CRT tasks the martial artists were no quicker in lifting their hand off a button in response to the stimulus [reaction time (RT)] but were significantly faster in moving to press another button [movement time (MT)]. In conclusion, the results reveal that training in a martial art increases the strength of both the flexors and extensors of the leg. Furthermore, they have faster movement times to auditory stimuli. These results are consistent with the physical aspects of the martial arts. Key Points Martial artists undertaking hard-style martial arts have greater strength in their knee flexor and extensor muscles as tested under isokinetic testing. Under isometric testing conditions they have stronger knee extensors only. The trunk musculature is generally higher under both conditions of testing in the martial artists, although not significantly. The total reaction times of the martial artists to an auditory stimulus were significantly faster than the control participants. When analysed further it was revealed that the decrease in reaction time was due to the movement time component of the total reaction time. The training involved for the practice of the hard-style martial arts increases the strength of muscles involved in kicking. This increased strength is not seen in the trunk muscles. Furthermore, martial artists have a faster response time; the cause of which appears to be only the faster movement time. PMID:24376366

Mechanical testing and development of the helical field coil joint for the Advanced Toroidal Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, B.E.; Bryan, W.E.; Goranson, P.L.

1985-01-01

The helical field (HF) coil set for the Advanced Toroidal Facility (ATF) is an M = 12, l = 2, constant-ratio torsatron winding consisting of 2 coils, each with 14 turns of heavy copper conductor. The coils are divided into 24 identical segments to facilitate fabrication and minimize the assembly schedule. The segments are connected across through-bolted lap joints that must carry up to 124,000 A per turn for 5 s or 62,500 A steady-state. In addition, the joints must carry the high magnetic and thermal loads induced in the conductor and still fit within the basic 140- by 30-mmmore » copper envelope. Extensive testing and development were undertaken to verify and refine the basic joint design. Tests included assembly force and clamping force for various types of misalignment; joint resistance as a function of clamping force; clamp bolt relaxation due to thermal cycling; fatigue testing of full-size, multiturn joint prototypes; and low-cycle fatigue and tensile tests of annealed CDA102 copper. The required performance parameters and actual test results, as well as the final joint configuration, are presented. 2 refs., 9 figs., 4 tabs.« less

Advanced Wireless Sensor Nodes - MSFC

NASA Technical Reports Server (NTRS)

Varnavas, Kosta; Richeson, Jeff

2017-01-01

NASA field center Marshall Space Flight Center (Huntsville, AL), has invested in advanced wireless sensor technology development. Developments for a wireless microcontroller back-end were primarily focused on the commercial Synapse Wireless family of devices. These devices have many useful features for NASA applications, good characteristics and the ability to be programmed Over-The-Air (OTA). The effort has focused on two widely used sensor types, mechanical strain gauges and thermal sensors. Mechanical strain gauges are used extensively in NASA structural testing and even on vehicle instrumentation systems. Additionally, thermal monitoring with many types of sensors is extensively used. These thermal sensors include thermocouples of all types, resistive temperature devices (RTDs), diodes and other thermal sensor types. The wireless thermal board will accommodate all of these types of sensor inputs to an analog front end. The analog front end on each of the sensors interfaces to the Synapse wireless microcontroller, based on the Atmel Atmega128 device. Once the analog sensor output data is digitized by the onboard analog to digital converter (A/D), the data is available for analysis, computation or transmission. Various hardware features allow custom embedded software to manage battery power to enhance battery life. This technology development fits nicely into using numerous additional sensor front ends, including some of the low-cost printed circuit board capacitive moisture content sensors currently being developed at Auburn University.

An improved method to determine neuromuscular properties using force laws - From single muscle to applications in human movements.

PubMed

Siebert, T; Sust, M; Thaller, S; Tilp, M; Wagner, H

2007-04-01

We evaluate an improved method for individually determining neuromuscular properties in vivo. The method is based on Hill's equation used as a force law combined with Newton's equation of motion. To ensure the range of validity of Hill's equation, we first perform detailed investigations on in vitro single muscles. The force-velocity relation determined with the model coincides well with results obtained by standard methods (r=.99) above 20% of the isometric force. In addition, the model-predicted force curves during work loop contractions very well agree with measurements (mean difference: 2-3%). Subsequently, we deduce theoretically under which conditions it is possible to combine several muscles of the human body to model muscles. This leads to a model equation for human leg extension movements containing parameters for the muscle properties and for the activation. To numerically determine these invariant neuromuscular properties we devise an experimental method based on concentric and isometric leg extensions. With this method we determine individual muscle parameters from experiments such that the simulated curves agree well with experiments (r=.99). A reliability test with 12 participants revealed correlations r=.72-.91 for the neuromuscular parameters (p<.01). Predictions of similar movements under different conditions show mean errors of about 5%. In addition, we present applications in sports practise and theory.

IMAPS Device Packaging Conference 2017 - Engineered Micro Systems & Devices Track

NASA Technical Reports Server (NTRS)

Varnavas, Kosta

2017-01-01

NASA field center Marshall Space Flight Center (Huntsville, AL), has invested in advanced wireless sensor technology development. Developments for a wireless microcontroller back-end were primarily focused on the commercial Synapse Wireless family of devices. These devices have many useful features for NASA applications, good characteristics and the ability to be programmed Over-The-Air (OTA). The effort has focused on two widely used sensor types, mechanical strain gauges and thermal sensors. Mechanical strain gauges are used extensively in NASA structural testing and even on vehicle instrumentation systems. Additionally, thermal monitoring with many types of sensors is extensively used. These thermal sensors include thermocouples of all types, resistive temperature devices (RTDs), diodes and other thermal sensor types. The wireless thermal board will accommodate all of these types of sensor inputs to an analog front end. The analog front end on each of the sensors interfaces to the Synapse wireless microcontroller, based on the Atmel Atmega128 device. Once the analog sensor output data is digitized by the onboard analog to digital converter (A/D), the data is available for analysis, computation or transmission. Various hardware features allow custom embedded software to manage battery power to enhance battery life. This technology development fits nicely into using numerous additional sensor front ends, including some of the low-cost printed circuit board capacitive moisture content sensors currently being developed at Auburn University.

Four-body extension of the continuum-discretized coupled-channels method

NASA Astrophysics Data System (ADS)

Descouvemont, P.

2018-06-01

I develop an extension of the continuum-discretized coupled-channels (CDCC) method to reactions where both nuclei present a low breakup threshold. This leads to a four-body model, where the only inputs are the interactions describing the colliding nuclei, and the four optical potentials between the fragments. Once these potentials are chosen, the model does not contain any additional parameter. First I briefly discuss the general formalism, and emphasize the need for dealing with large coupled-channel systems. The method is tested with existing benchmarks on 4 α bound states with the Ali-Bodmer potential. Then I apply the four-body CDCC to the 11Be+d system, where I consider the 10Be(0+,2+)+n configuration for 11Be. I show that breakup channels are crucial to reproduce the elastic cross section, but that core excitation plays a weak role. The 7Li+d system is investigated with an α +t cluster model for 7Li. I show that breakup channels significantly improve the agreement with the experimental cross section, but an additional imaginary term, simulating missing transfer channels, is necessary. The full CDCC results can be interpreted by equivalent potentials. For both systems, the real part is weakly affected by breakup channels, but the imaginary part is strongly modified. I suggest that the present wave functions could be used in future DWBA calculations.

Forces directing germ-band extension in Drosophila embryos.

PubMed

Kong, Deqing; Wolf, Fred; Großhans, Jörg

2017-04-01

Body axis elongation by convergent extension is a conserved developmental process found in all metazoans. Drosophila embryonic germ-band extension is an important morphogenetic process during embryogenesis, by which the length of the germ-band is more than doubled along the anterior-posterior axis. This lengthening is achieved by typical convergent extension, i.e. narrowing the lateral epidermis along the dorsal-ventral axis and simultaneous extension along the anterior-posterior axis. Germ-band extension is largely driven by cell intercalation, whose directionality is determined by the planar polarity of the tissue and ultimately by the anterior-posterior patterning system. In addition, extrinsic tensile forces originating from the invaginating endoderm induce cell shape changes, which transiently contribute to germ-band extension. Here, we review recent progress in understanding of the role of mechanical forces in germ-band extension. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Test-Retest Reliability of Rating of Perceived Exertion and Agreement With 1-Repetition Maximum in Adults.

PubMed

Bove, Allyn M; Lynch, Andrew D; DePaul, Samantha M; Terhorst, Lauren; Irrgang, James J; Fitzgerald, G Kelley

2016-09-01

Study Design Clinical measurement. Background It has been suggested that rating of perceived exertion (RPE) may be a useful alternative to 1-repetition maximum (1RM) to determine proper resistance exercise dosage. However, the test-retest reliability of RPE for resistance exercise has not been determined. Additionally, prior research regarding the relationship between 1RM and RPE is conflicting. Objectives The purpose of this study was to (1) determine test-retest reliability of RPE related to resistance exercise and (2) assess agreement between percentages of 1RM and RPE during quadriceps resistance exercise. Methods A sample of participants with and without knee pathology completed a series of knee extension exercises and rated the perceived difficulty of each exercise on a 0-to-10 RPE scale, then repeated the procedure 1 to 2 weeks later for test-retest reliability. To determine agreement between RPE and 1RM, participants completed knee extension exercises at various percentages of their 1RM (10% to 130% of predicted 1RM) and rated the perceived difficulty of each exercise on a 0-to-10 RPE scale. Percent agreement was calculated between the 1RM and RPE at each resistance interval. Results The intraclass correlation coefficient indicated excellent test-retest reliability of RPE for quadriceps resistance exercises (intraclass correlation coefficient = 0.895; 95% confidence interval: 0.866, 0.918). Overall percent agreement between RPE and 1RM was 60%, but agreement was poor within the ranges that would typically be used for training (50% 1RM for muscle endurance, 70% 1RM and greater for strength). Conclusion Test-retest reliability of perceived exertion during quadriceps resistance exercise was excellent. However, agreement between the RPE and 1RM was poor, especially in common training zones for knee extensor strengthening. J Orthop Sports Phys Ther 2016;46(9):768-774. Epub 5 Aug 2016. doi:10.2519/jospt.2016.6498.

Role of the Middle Lumbar Fascia on Spinal Mechanics: A Human Biomechanical Assessment.

PubMed

Ranger, Tom A; Newell, Nicolas; Grant, Caroline A; Barker, Priscilla J; Pearcy, Mark J

2017-04-15

Biomechanical experiment. The aims of the present study were to test the effect of fascial tension on lumbar segmental axial rotation and lateral flexion and the effect of the angle of fascial attachment. Tension in the middle layer of lumbar fascia has been demonstrated to affect mechanical properties of lumbar segmental flexion and extension in the neutral zone. The effect of tension on segmental axial rotation and lateral flexion has, however, not been investigated. Seven unembalmed lumbar spines were divided into segments and mounted for testing. A 6 degree-of-freedom robotic testing facility was used to displace the segments in each anatomical plane (flexion-extension, lateral bending, and axial rotation) with force and moment data recorded by a load cell positioned beneath the test specimen. Tests were performed with and without a 20 N fascia load and the subsequent forces and moments were compared. In addition, forces and moments were compared when the specimens were held in a set position and the fascia loading angle was varied. A fascial tension of 20 N had no measurable effect on the forces or moments measured when the specimens were displaced in any plane of motion (P > 0.05). When 20 N of fascial load were applied to motion segments in a set position small segmental forces and moments were measured. Changing the angle of the fascial load did not significantly alter these measurements. Application of a 20 N fascial load did not produce a measureable effect on the mechanics of a motion segment, even though it did produce small measurable forces and moments on the segments when in a fixed position. Results from the present study are inconsistent with previous studies, suggesting that further investigation using multiple testing protocols and different loading conditions is required to determine the effects of fascial loading on spinal segment behavior. N/A.

Forced knee extension test is a manual test that correlates with the unstable feelings of patients with ACL injury before and after reconstruction.

PubMed

Shirasawa, Shinichi; Koga, Hideyuki; Horie, Masafumi; Nakamura, Tomomasa; Watanabe, Toshifumi; Sekiya, Ichiro; Muneta, Takeshi

2016-12-01

To investigate fear in patients with anterior cruciate ligament (ACL) injury before and after reconstruction, a forced knee extension (FKE) test was performed. The correlation of the test results was evaluated with the subjective function, sports performance and objective parameters. The study included 102 patients with unilateral ACL reconstruction using a semitendinosus tendon with full clinical evaluation. This study was retrospective and determined the longitudinal results of the FKE test and investigated the effects on the subjective and objective outcomes at 2years. Preoperatively, 47% of patients showed positive FKE tests. The number of positive FKE tests was 31% at six months and 15% at 24months after ACL reconstruction. At two years, there were statistically significant differences between the FKE test positives and negatives regarding both subjective knee recovery (P=0.0095) and sports performance (P=0.0006). A new manual test, called the forced knee extension test, for fear in patients with ACL injury before and after reconstruction was introduced. The apprehension remained positive in 15% of the patients two years after ACL reconstruction, which affected subjective recovery of knee function and sports performance. Copyright © 2016 Elsevier B.V. All rights reserved.

STAR -Space Time Asymmetry Research

NASA Astrophysics Data System (ADS)

van Zoest, Tim; Braxmaier, Claus; Schuldt, Thilo; Allab, Mohammed; Theil, Stephan; Pelivan, Ivanka; Herrmann, Sven; Lümmerzahl, Claus; Peters, Achim; Mühle, Katharina; Wicht, Andreas; Nagel, Moritz; Kovalchuk, Evgeny; Düringshoff, Klaus; Dittus, Hansjürg

STAR is a proposed satellite mission that aims for significantly improved tests of fundamental space-time symmetry and the foundations of special and general relativity. In total STAR comprises a series of five subsequent missions. The STAR1 mission will measure the constancy of the speed of light to one part in 1019 and derive the Kennedy Thorndike (KT) coefficient of the Mansouri-Sexl test theory to 7x10-10 . The KT experiment will be performed by compar-ison of an iodine standard with a highly stable cavity made from ultra low expansion (ULE) ceramics. With an orbital velocity of 7 km/s the sensitivity to a boost dependent violation of Lorentz invariance as modeled by the KT term in the Mansouri Sexl test theory or a Lorentz violating extension of the standard model (SME) will be significantly enhanced as compared to Earth based experiments. The low noise space environment will additionally enhance the measurement precision such that an overall improvement by a factor of 400 over current Earth based experiments is expected.

Scapular instability associated with brachial plexus irritation: a proposed causative relationship with treatment implications.

PubMed

Langley, P

1997-01-01

Brachial plexus irritation and other compression neuropathies can be diverse in their presentations and can cause a myriad of signs and symptoms. The purpose of this paper is to review the pertinent anatomy, kinesiology, and neurophysiology and to outline one possible cascade of events that may contribute to more diffuse upper extremity symptoms. Scapular instability and local myofascial trigger points resulting in possible secondary muscle imbalances are described. Their possible relationship to brachial plexus irritation in addition to the implications of the irritation are also discussed. The author postulates that proximal nerve irritation in the region of the thoracic outlet and shoulder may help to account for diffuse or unrelieved symptoms following conventional treatment of distal extremity problems in patients with occupational or cumulative trauma disorders. This paper outlines specific examination procedures for the therapist, which include upper limb tension testing, extensibility testing of the pectoralis minor, and gross manual muscle testing of the lower trapezius.

pyRMSD: a Python package for efficient pairwise RMSD matrix calculation and handling.

PubMed

Gil, Víctor A; Guallar, Víctor

2013-09-15

We introduce pyRMSD, an open source standalone Python package that aims at offering an integrative and efficient way of performing Root Mean Square Deviation (RMSD)-related calculations of large sets of structures. It is specially tuned to do fast collective RMSD calculations, as pairwise RMSD matrices, implementing up to three well-known superposition algorithms. pyRMSD provides its own symmetric distance matrix class that, besides the fact that it can be used as a regular matrix, helps to save memory and increases memory access speed. This last feature can dramatically improve the overall performance of any Python algorithm using it. In addition, its extensibility, testing suites and documentation make it a good choice to those in need of a workbench for developing or testing new algorithms. The source code (under MIT license), installer, test suites and benchmarks can be found at https://pele.bsc.es/ under the tools section. victor.guallar@bsc.es Supplementary data are available at Bioinformatics online.

Investigation of Aerodynamics Scale Effects for a Generic Fighter Configuration in the National Transonic Facility (Invited)

NASA Technical Reports Server (NTRS)

Tomek, W. G.; Wahls, R. A.; Owens, L. R.; Burner, A. B.; Graves, S. S.; Luckring, J. M.

2003-01-01

Two wind tunnel tests of a generic fighter configuration have been completed in the National Transonic Facility. The primary purpose of the tests was to assess Reynolds number scale effects on a thin-wing, fighter-type configuration up to full-scale flight conditions (that is, Reynolds numbers of the order of 60 million). The tests included longitudinal and lateral/directional studies at subsonic and transonic conditions across a range of Reynolds numbers from that available in conventional wind tunnels to flight conditions. Results are presented for three Mach numbers (0.6, 0.8, and 0.9) and three configurations: 1) Fuselage / Wing, 2) Fuselage / Wing / Centerline Vertical Tail / Horizontal Tail, and 3) Fuselage / Wing / Trailing-Edge Extension / Twin Vertical Tails. Reynolds number effects on the lateral-directional aerodynamic characteristics are presented herein, along with longitudinal data demonstrating the effects of fixing the boundary layer transition location for low Reynolds number conditions. In addition, an improved model videogrammetry system and results are discussed.

PAGEMS

NASA Technical Reports Server (NTRS)

Bulzan, Dan

2001-01-01

Glenn Research Center has extensive instrumentation developed for measuring particulate and gaseous emissions. The Particulate and Gaseous Emissions Measurement System (PAGEMS) is a mobile facility housing advanced instrumentation used for measuring combustion particulates and gaseous species. Particulates sizes ranging from 10 nm to 10 mm can be measured along with SO2, NO, NO2, CO, CO2, THC and O2 . Measurements can be made from subatmospheric up to 60 atm. Representative data from two engine tests will be discussed. In one test, the fuel sulfur content was changed, while the other test (T-63 engine) used various fuel additives. Probe design is essential to acquiring accurate particulate data. I will discuss the AEDC designed particulate probe, and the results of a University of Minnesota calibration study using the probe. Another suite of instrumentation, a tunable diode laser (TDL), enables in-situ real time gaseous species measurements. Representative TDL data from a T-38 aircraft will be presented. In conclusion, near term measurement opportunities will be discussed.

Mechanical behavior of high strength ceramic fibers at high temperatures

NASA Technical Reports Server (NTRS)

Tressler, R. E.; Pysher, D. J.

1991-01-01

The mechanical behavior of commercially available and developmental ceramic fibers, both oxide and nonoxide, has been experimentally studied at expected use temperatures. In addition, these properties have been compared to results from the literature. Tensile strengths were measured for three SiC-based and three oxide ceramic fibers for temperatures from 25 C to 1400 C. The SiC-based fibers were stronger but less stiff than the oxide fibers at room temperature and retained more of both strength and stiffness to high temperatures. Extensive creep and creep-rupture experiments have been performed on those fibers from this group which had the best strengths above 1200 C in both single filament tests and tests of fiber bundles. The creep rates for the oxides are on the order of two orders of magnitude faster than the polymer derived nonoxide fibers. The most creep resistant filaments available are single crystal c-axis sapphire filaments. Large diameter CVD fabricated SiC fibers are the most creep and rupture resistant nonoxide polycrystalline fibers tested to date.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christon, Mark A.; Baksoi, Jozsef; Barnett, Nathan

This report describes the work carried out for completion of the Thermal Hydraulics Methods (THM) Level 2 Milestone THM.CFD.P5.01 for the Consortium for Advanced Simulation of Light Water Reactors (CASL). This milestone focused primarily on the initial integration of Hydra-TH in VERA. The primary objective for this milestone was the integration of Hydra-TH as a standalone executable in VERA. A series of code extensions/modifications have been made to Hydra-TH to facilitate integration of Hydra-TH in VERA and to permit future tighter integration and physics coupling. A total of 61 serial and 64 parallel regression tests have been supplied with Hydra-TH.more » These tests are are being executed in the TriBITS environment. Once the VERA team enables the full suite of tests, the results can be posted to the VERA CDash site. Future work will consider the use of the LIME 2.0 interface for tighter integration in VERA with additional efforts focused on multiphysics coupling with radiation transport, fuel performance, and solid/structural mechanics.« less

Research in millimeter wave techniques

NASA Technical Reports Server (NTRS)

Mcmillan, R. W.

1978-01-01

During the past six months, efforts on this project have been devoted to: (1) continuation of construction and testing of a 6 GHz subharmonic mixer model with extension of the pumping frequency of this mixer to omega sub s/4, (2) construction of a 183 GHz subharmonic mixer based on the results of tests on this 6 GHz model, (3) ground-based radiometric measurements at 183 GHz, (4) fabrication and testing of wire grid interferometers, (5) calculations of reflected and lost power in these interferometers, and (6) calculations of the antenna temperature due to water vapor to be expected in down-looking radiometry as a function of frequency. Significant events during the past six months include: (1) Receipt of a 183 GHz single-ended fundamental mixer, (2) attainment of 6 db single sideband conversion loss with the 6 GHz subharmonic mixer model by using a 1.5 GHz (omega sub s/4) pump frequency, (3) additional ground-based radiometric measurements and (4) derivation of equations for reflection and loss for wire grid interferometers.

Teaching Human Digestion and pH Using Technology

ERIC Educational Resources Information Center

Kim, Hanna

2008-01-01

Testing the pH of various liquids is one of the most popular activities in 5th- through 8th-grade classrooms. The author presents an extensive pH-testing lesson based on a 5E (engagement, exploration, explanation, extension, and evaluation) teaching model. The activity provides students with the opportunity to learn about pH and how it relates to…

Testing for association with multiple traits in generalized estimation equations, with application to neuroimaging data.

PubMed

Zhang, Yiwei; Xu, Zhiyuan; Shen, Xiaotong; Pan, Wei

2014-08-01

There is an increasing need to develop and apply powerful statistical tests to detect multiple traits-single locus associations, as arising from neuroimaging genetics and other studies. For example, in the Alzheimer's Disease Neuroimaging Initiative (ADNI), in addition to genome-wide single nucleotide polymorphisms (SNPs), thousands of neuroimaging and neuropsychological phenotypes as intermediate phenotypes for Alzheimer's disease, have been collected. Although some classic methods like MANOVA and newly proposed methods may be applied, they have their own limitations. For example, MANOVA cannot be applied to binary and other discrete traits. In addition, the relationships among these methods are not well understood. Importantly, since these tests are not data adaptive, depending on the unknown association patterns among multiple traits and between multiple traits and a locus, these tests may or may not be powerful. In this paper we propose a class of data-adaptive weights and the corresponding weighted tests in the general framework of generalized estimation equations (GEE). A highly adaptive test is proposed to select the most powerful one from this class of the weighted tests so that it can maintain high power across a wide range of situations. Our proposed tests are applicable to various types of traits with or without covariates. Importantly, we also analytically show relationships among some existing and our proposed tests, indicating that many existing tests are special cases of our proposed tests. Extensive simulation studies were conducted to compare and contrast the power properties of various existing and our new methods. Finally, we applied the methods to an ADNI dataset to illustrate the performance of the methods. We conclude with the recommendation for the use of the GEE-based Score test and our proposed adaptive test for their high and complementary performance. Copyright © 2014 Elsevier Inc. All rights reserved.

A comparison of manual and quantitative elbow strength testing.

PubMed

Shahgholi, Leili; Bengtson, Keith A; Bishop, Allen T; Shin, Alexander Y; Spinner, Robert J; Basford, Jeffrey R; Kaufman, Kenton R

2012-10-01

The aim of this study was to compare the clinical ratings of elbow strength obtained by skilled clinicians with objective strength measurement obtained through quantitative testing. A retrospective comparison of subject clinical records with quantitative strength testing results in a motion analysis laboratory was conducted. A total of 110 individuals between the ages of 8 and 65 yrs with traumatic brachial plexus injuries were identified. Patients underwent manual muscle strength testing as assessed on the 5-point British Medical Research Council Scale (5/5, normal; 0/5, absent) and quantitative elbow flexion and extension strength measurements. A total of 92 subjects had elbow flexion testing. Half of the subjects clinically assessed as having normal (5/5) elbow flexion strength on manual muscle testing exhibited less than 42% of their age-expected strength on quantitative testing. Eighty-four subjects had elbow extension strength testing. Similarly, half of those displaying normal elbow extension strength on manual muscle testing were found to have less than 62% of their age-expected values on quantitative testing. Significant differences between manual muscle testing and quantitative findings were not detected for the lesser (0-4) strength grades. Manual muscle testing, even when performed by experienced clinicians, may be more misleading than expected for subjects graded as having normal (5/5) strength. Manual muscle testing estimates for the lesser strength grades (1-4/5) seem reasonably accurate.

Colors of attraction: Modeling insect flight to light behavior.

PubMed

Donners, Maurice; van Grunsven, Roy H A; Groenendijk, Dick; van Langevelde, Frank; Bikker, Jan Willem; Longcore, Travis; Veenendaal, Elmar

2018-06-26

Light sources attract nocturnal flying insects, but some lamps attract more insects than others. The relation between the properties of a light source and the number of attracted insects is, however, poorly understood. We developed a model to quantify the attractiveness of light sources based on the spectral output. This model is fitted using data from field experiments that compare a large number of different light sources. We validated this model using two additional datasets, one for all insects and one excluding the numerous Diptera. Our model facilitates the development and application of light sources that attract fewer insects without the need for extensive field tests and it can be used to correct for spectral composition when formulating hypotheses on the ecological impact of artificial light. In addition, we present a tool allowing the conversion of the spectral output of light sources to their relative insect attraction based on this model. © 2018 Wiley Periodicals, Inc.

Plasma facing materials and components for future fusion devices—development, characterization and performance under fusion specific loading conditions

NASA Astrophysics Data System (ADS)

Linke, J.

2006-04-01

The plasma exposed components in existing and future fusion devices are strongly affected by the plasma material interaction processes. These mechanisms have a strong influence on the plasma performance; in addition they have major impact on the lifetime of the plasma facing armour and the joining interface between the plasma facing material (PFM) and the heat sink. Besides physical and chemical sputtering processes, high heat quasi-stationary fluxes during normal and intense thermal transients are of serious concern for the engineers who develop reliable wall components. In addition, the material and component degradation due to intense fluxes of energetic neutrons is another critical issue in D-T-burning fusion devices which requires extensive R&D. This paper presents an overview on the materials development and joining, the testing of PFMs and components, and the analysis of the neutron irradiation induced degradation.

Flight investigation of cockpit-displayed traffic information utilizing coded symbology in an advanced operational environment

NASA Technical Reports Server (NTRS)

Abbott, T. S.; Moen, G. C.; Person, L. H., Jr.; Keyser, G. L., Jr.; Yenni, K. R.; Garren, J. F., Jr.

1980-01-01

Traffic symbology was encoded to provide additional information concerning the traffic, which was displayed on the pilot's electronic horizontal situation indicators (EHSI). A research airplane representing an advanced operational environment was used to assess the benefit of coded traffic symbology in a realistic work-load environment. Traffic scenarios, involving both conflict-free and conflict situations, were employed. Subjective pilot commentary was obtained through the use of a questionnaire and extensive pilot debriefings. These results grouped conveniently under two categories: display factors and task performance. A major item under the display factor category was the problem of display clutter. The primary contributors to clutter were the use of large map-scale factors, the use of traffic data blocks, and the presentation of more than a few airplanes. In terms of task performance, the cockpit-displayed traffic information was found to provide excellent overall situation awareness. Additionally, mile separation prescribed during these tests.

Respiratory motion correction in emission tomography image reconstruction.

PubMed

Reyes, Mauricio; Malandain, Grégoire; Koulibaly, Pierre Malick; González Ballester, Miguel A; Darcourt, Jacques

2005-01-01

In Emission Tomography imaging, respiratory motion causes artifacts in lungs and cardiac reconstructed images, which lead to misinterpretations and imprecise diagnosis. Solutions like respiratory gating, correlated dynamic PET techniques, list-mode data based techniques and others have been tested with improvements over the spatial activity distribution in lungs lesions, but with the disadvantages of requiring additional instrumentation or discarding part of the projection data used for reconstruction. The objective of this study is to incorporate respiratory motion correction directly into the image reconstruction process, without any additional acquisition protocol consideration. To this end, we propose an extension to the Maximum Likelihood Expectation Maximization (MLEM) algorithm that includes a respiratory motion model, which takes into account the displacements and volume deformations produced by the respiratory motion during the data acquisition process. We present results from synthetic simulations incorporating real respiratory motion as well as from phantom and patient data.

Nuisance or Not? Part 2 "Wood" New Additives Make a Difference?

NASA Astrophysics Data System (ADS)

Vilardi, J. R.

2017-12-01

Nuisance or Not? Part 2"Wood" New Additives Make a Difference? Julian Vilardi Wetumpka Middle School, Wetumpka, USA Last year fuel briquettes were created out of nuisance organisms. Several samples had results better or comparable to the controls. This project is a revision/ extension. Purpose: Find process and formula for a long lasting environmentally friendly biofuel that produces high energy with low byproducts and low cost. Hypotheses: If wisteria is processed to make a biofuel that contains 90% wisteria leaves and vines and 10% pine cones, then a high energy, low byproduct, biofuel will be created. Procedure: Collect, dry and chop material, compress mass, burn test, repeat for every organism. Kudzu was combined in a 70 % kudzu: 30 % wood additive with used cooking oil and pressed into logs. Logs were massed, burned and temperature was recorded and compared to controls. Results: Kudzu had the longest flame but produced smoke. Kudzu logs with recycled cooking oil had less smoke and burned for an hour plus. Conclusions: Wisteria did not compact or have great flammability. Pine cones did not flame well either. This hypothesis was unsupported. All kudzu samples when compacted and combined with any additive were the best biofuel. Kudzu logs with the mixture of wood additives burned the longest and was one of the hottest. The gas chromatograph/emissions tests showed the organic byproducts produced on burning the kudzu logs were less than the accepted range for air quality. These supported the hypothesis and met the purpose of this project. A low cost, environmentally friendly, efficient fuel source was created!

A dynamic motion simulator for future European docking systems

NASA Technical Reports Server (NTRS)

Brondino, G.; Marchal, PH.; Grimbert, D.; Noirault, P.

1990-01-01

Europe's first confrontation with docking in space will require extensive testing to verify design and performance and to qualify hardware. For this purpose, a Docking Dynamics Test Facility (DDTF) was developed. It allows reproduction on the ground of the same impact loads and relative motion dynamics which would occur in space during docking. It uses a 9 degree of freedom, servo-motion system, controlled by a real time computer, which simulates the docking spacecraft in a zero-g environment. The test technique involves and active loop based on six axis force and torque detection, a mathematical simulation of individual spacecraft dynamics, and a 9 degree of freedom servomotion of which 3 DOFs allow extension of the kinematic range to 5 m. The configuration was checked out by closed loop tests involving spacecraft control models and real sensor hardware. The test facility at present has an extensive configuration that allows evaluation of both proximity control and docking systems. It provides a versatile tool to verify system design, hardware items and performance capabilities in the ongoing HERMES and COLUMBUS programs. The test system is described and its capabilities are summarized.

Linking Research, Extension and Farmers: The Case of Mangrove Swamp Rice Cultivation in Sierra Leone.

ERIC Educational Resources Information Center

Zinnah, Moses Moroe

1994-01-01

Interviews with 124 rice farmers in Sierra Leone revealed that farmers and extension staff have minimal participation and input in testing of new cultivation technologies. The top-down research approach has limited contact among researchers, extension staff, and farmers and affected the utility and application of research. (SK)

Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 12: PEP data item descriptions

NASA Technical Reports Server (NTRS)

1979-01-01

Contractor information requirements necessary to support the power extension package project of the space shuttle program are specified for the following categories of data: project management; configuration management; systems engineering and test; manufacturing; reliability, quality assurance and safety; logistics; training; and operations.

The Intelligent System of Cardiovascular Disease Diagnosis Based on Extension Data Mining

NASA Astrophysics Data System (ADS)

Sun, Baiqing; Li, Yange; Zhang, Lin

This thesis gives the general definition of the concepts of extension knowledge, extension data mining and extension data mining theorem in high dimension space, and also builds the IDSS integrated system by the rough set, expert system and neural network, develops the relevant computer software. From the diagnosis tests, according to the common diseases of myocardial infarctions, angina pectoris and hypertension, and made the test result with physicians, the results shows that the sensitivity, specific and accuracy diagnosis by the IDSS are all higher than the physicians. It can improve the rate of the accuracy diagnosis of physician with the auxiliary help of this system, which have the obvious meaning in low the mortality, disability rate and high the survival rate, and has strong practical values and further social benefits.

76 FR 2674 - Proposed Waiver and Extension of Project Period

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

... the project. Additionally, PIRCs conducting experimental design studies experienced logistical challenges associated with establishing treatment and control groups. An additional year of funding would...

Reliability and measurement error of active knee extension range of motion in a modified slump test position: a pilot study.

PubMed

Tucker, Neil; Reid, Duncan; McNair, Peter

2007-01-01

The slump test is a tool to assess the mechanosensitivity of the neuromeningeal structures within the vertebral canal. While some studies have investigated the reliability of aspects of this test within the same day, few have assessed the reliability across days. Therefore, the purpose of this pilot study was to investigate reliability when measuring active knee extension range of motion (AROM) in a modified slump test position within trials on a single day and across days. Ten male and ten female asymptomatic subjects, ages 20-49 (mean age 30.1, SD 6.4) participated in the study. Knee extension AROM in a modified slump position with the cervical spine in a flexed position and then in an extended position was measured via three trials on two separate days. Across three trials, knee extension AROM increased significantly with a mean magnitude of 2 degrees within days for both cervical spine positions (P>0.05). The findings showed that there was no statistically significant difference in knee extension AROM measurements across days (P>0.05). The intraclass correlation coefficients for the mean of the three trials across days were 0.96 (lower limit 95% CI: 0.90) with the cervical spine flexed and 0.93 (lower limit 95% CI: 0.83) with cervical extension. Measurement error was calculated by way of the typical error and 95% limits of agreement, and visually represented in Bland and Altman plots. The typical error for the cervical flexed and extended positions averaged across trials was 2.6 degrees and 3.3 degrees , respectively. The limits of agreement were narrow, and the Bland and Altman plots also showed minimal bias in the joint angles across days with a random distribution of errors across the range of measured angles. This study demonstrated that knee extension AROM could be reliably measured across days in subjects without pathology and that the measurement error was acceptable. Implications of variability over multiple trials are discussed. The modified set-up for the test using the Kincom dynamometer and elevated thigh position may be useful to clinical researchers in determining the mechanosensitivity of the nervous system.

Reliability and Measurement Error of Active Knee Extension Range of Motion in a Modified Slump Test Position: A Pilot Study

PubMed Central

Tucker, Neil; Reid, Duncan; McNair, Peter

2007-01-01

The slump test is a tool to assess the mechanosensitivity of the neuromeningeal structures within the vertebral canal. While some studies have investigated the reliability of aspects of this test within the same day, few have assessed the reliability across days. Therefore, the purpose of this pilot study was to investigate reliability when measuring active knee extension range of motion (AROM) in a modified slump test position within trials on a single day and across days. Ten male and ten female asymptomatic subjects, ages 20–49 (mean age 30.1, SD 6.4) participated in the study. Knee extension AROM in a modified slump position with the cervical spine in a flexed position and then in an extended position was measured via three trials on two separate days. Across three trials, knee extension AROM increased significantly with a mean magnitude of 2° within days for both cervical spine positions (P>0.05). The findings showed that there was no statistically significant difference in knee extension AROM measurements across days (P>0.05). The intraclass correlation coefficients for the mean of the three trials across days were 0.96 (lower limit 95% CI: 0.90) with the cervical spine flexed and 0.93 (lower limit 95% CI: 0.83) with cervical extension. Measurement error was calculated by way of the typical error and 95% limits of agreement, and visually represented in Bland and Altman plots. The typical error for the cervical flexed and extended positions averaged across trials was 2.6° and 3.3°, respectively. The limits of agreement were narrow, and the Bland and Altman plots also showed minimal bias in the joint angles across days with a random distribution of errors across the range of measured angles. This study demonstrated that knee extension AROM could be reliably measured across days in subjects without pathology and that the measurement error was acceptable. Implications of variability over multiple trials are discussed. The modified set-up for the test using the Kincom dynamometer and elevated thigh position may be useful to clinical researchers in determining the mechanosensitivity of the nervous system. PMID:19066666

A conceptual framework for dynamic extension of the red clearance interval as a countermeasure for red-light-running.

PubMed

Gates, Timothy J; Noyce, David A

2016-11-01

This manuscript describes the development and evaluation of a conceptual framework for real-time operation of dynamic on-demand extension of the red clearance interval as a countermeasure for red-light-running. The framework includes a decision process for determining, based on the real-time status of vehicles arriving at the intersection, when extension of the red clearance interval should occur and the duration of each extension. A zonal classification scheme was devised to assess whether an approaching vehicle requires additional time to safely clear the intersection based on the remaining phase time, type of vehicle, current speed, and current distance from the intersection. Expected performance of the conceptual framework was evaluated through modeling of replicated field operations using vehicular event data collected as part of this research. The results showed highly accurate classification of red-light-running vehicles needing additional clearance time and relatively few false extension calls from stopping vehicles, thereby minimizing the expected impacts to signal and traffic operations. Based on the recommended parameters, extension calls were predicted to occur once every 26.5cycles. Assuming a 90scycle, 1.5 extensions per hour were expected per approach, with an estimated extension time of 2.30s/h. Although field implementation was not performed, it is anticipated that long-term reductions in targeted red-light-running conflicts and crashes will likely occur if red clearance interval extension systems are implemented at locations where start-up delay on the conflicting approach is generally minimal, such as intersections with lag left-turn phasing. Copyright © 2015 Elsevier Ltd. All rights reserved.

The STROBE extensions: protocol for a qualitative assessment of content and a survey of endorsement.

PubMed

Sharp, Melissa K; Utrobičić, Ana; Gómez, Guadalupe; Cobo, Erik; Wager, Elizabeth; Hren, Darko

2017-10-22

The STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) Statement was developed in response to inadequate reporting of observational studies. In recent years, several extensions to STROBE have been created to provide more nuanced field-specific guidance for authors. The content and the prevalence of extension endorsement have not yet been assessed. Accordingly, there are two aims: (1) to classify changes made in the extensions to identify strengths and weaknesses of the original STROBE checklist and (2) to determine the prevalence and typology of endorsement by journals in fields related to extensions. Two independent researchers will assess additions in each extension. Additions will be coded as 'field specific' (FS) or 'not field specific' (NFS). FS is defined as particularly relevant information for a single field and guidance provided generally cannot be extrapolated beyond that field. NFS is defined as information that reflects epidemiological or methodological tenets and can be generalised to most, if not all, types of observational research studies. Intraclass correlation will be calculated to measure reviewers' concordance. On disagreement, consensus will be sought. Individual additions will be grouped by STROBE checklist items to identify the frequency and distribution of changes.Journals in fields related to extensions will be identified through National Library of Medicine PubMed Broad Subject Terms, screened for eligibility and further distilled via Ovid MEDLINE® search strategies for observational studies. Text describing endorsement will be extracted from each journal's website. A classification scheme will be created for endorsement types and the prevalence of endorsement will be estimated. Analyses will use NVivo V.11 and SAS University Edition. This study does not require ethical approval as it does not involve human participants. This study has been preregistered on Open Science Framework. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Post-Flight Analysis of the Guidance, Navigation, and Control Performance During Orion Exploration Flight Test 1

NASA Technical Reports Server (NTRS)

Barth, Andrew; Mamich, Harvey; Hoelscher, Brian

2015-01-01

The first test flight of the Orion Multi-Purpose Crew Vehicle presented additional challenges for guidance, navigation and control as compared to a typical re-entry from the International Space Station or other Low Earth Orbit. An elevated re-entry velocity and steeper flight path angle were chosen to achieve aero-thermal flight test objectives. New IMU's, a GPS receiver, and baro altimeters were flight qualified to provide the redundant navigation needed for human space flight. The guidance and control systems must manage the vehicle lift vector in order to deliver the vehicle to a precision, coastal, water landing, while operating within aerodynamic load, reaction control system, and propellant constraints. Extensive pre-flight six degree-of-freedom analysis was performed that showed mission success for the nominal mission as well as in the presence of sensor and effector failures. Post-flight reconstruction analysis of the test flight is presented in this paper to show whether that all performance metrics were met and establish how well the pre-flight analysis predicted the in-flight performance.

Design and prototype tests of a seismic attenuation system for the advanced-LIGO output mode cleaner

NASA Astrophysics Data System (ADS)

Bertolini, A.; DeSalvo, R.; Galli, C.; Gennaro, G.; Mantovani, M.; Márka, S.; Sannibale, V.; Takamori, A.; Torrie, C.

2006-04-01

Both present LIGO and advanced LIGO (Ad-LIGO) will need an output mode cleaner (OMC) to reach the desired sensitivity. We designed a suitable OMC seismically attenuated optical table fitting to the existing vacuum chambers (horizontal access module, HAM chambers). The most straightforward and cost-effective solution satisfying the Ad-LIGO seismic attenuation specifications was to implement a single passive seismic attenuation stage, derived from the 'seismic attenuation system' (SAS) concept. We built and tested prototypes of all critical components. On the basis of these tests and past experience, we expect that the passive attenuation performance of this new design, called HAM-SAS, will match all requirements for the LIGO OMC, and all Ad-LIGO optical tables. Its performance can be improved, if necessary, by implementation of a simple active attenuation loop at marginal additional cost. The design can be easily modified to equip the LIGO basic symmetric chamber (BSC) chambers and leaves space for extensive performance upgrades for future evolutions of Ad-LIGO. Design parameters and prototype test results are presented.

Comparison of Environmentally Friendly Space Compatible Grease to its Predecessor in a Space Mechanism Bearing Test Rig

NASA Technical Reports Server (NTRS)

Jett, T. R.; Baker, M. A.; Thom, R. L.

1997-01-01

Perfluoroakylpolyether (PFPE) greases are used extensively in critical flight hardware in a space environment. In the past, these greases have been processed using chlorofluorocarbon (CFC) based solvents. In response to the recent ban of CFC's, new formulations of environmentally friendly PFPE greases that are not processed with CFC based solvents were developed. The purpose of this study was to compare the performance of a new environmentally friendly formulation PFPE grease to a previously proven space compatible formulation PFPE grease. A one year test using 20 small electrical motors (two bearings per motor) was conducted in a high vacuum environment(2.0 x 10(exp 4)) Torr at a temperature of 90 C. Twenty bearings were lubricated with a new environmentally friendly formulation, and twenty bearings were lubricated with an old formulation. The mass of each lubricated bearing was measured both pre and post test. Along with mass loss measurements a profilometer trace was taken to measure post test wear of the bearings. In addition the bearings were visually examined and analyzed using an optical microscope.

Safety assessment of the Cistanche tubulosa health food product Memoregain®: Genotoxicity and 28-day repeated dose toxicity test.

PubMed

Liao, Po-Lin; Li, Ching-Hao; Tse, Ling-Shan; Kang, Jaw-Jou; Cheng, Yu-Wen

2018-06-07

The pharmacological effects of Cistanches Herba, known as "Ginseng of the desert", have been extensively studied. In this study, we aimed to assess the genotoxic and oral toxic effects of the Cistanche tubulosa health food product Memoregain ® using in vitro and in vivo tests. Ames tests using five strains of Salmonella typhimurium showed no signs of increased reverse mutation upon exposure to Memoregain ® up to a concentration of 5 mg/plate. Exposure of Chinese hamster ovary (CHO-K1) cells to Memoregain ® did not increase the frequency of chromosomal aberrations in vitro. Moreover, Memoregain ® treatment did not affect the proportions of immature to total erythrocytes or the number of micronuclei in the immature erythrocytes of ICR mice. Additionally, after 28-day repeated oral dose toxicity tests (0, 0.15, 0.3, and 0.5g/kg body weight) in rats, no observable adverse effects were found. These toxicological assessments supported the safety of Memoregain ® for human consumption. Copyright © 2018 Elsevier Ltd. All rights reserved.

Cumulative toxicity of neonicotinoid insecticide mixtures to Chironomus dilutus under acute exposure scenarios.

PubMed

Maloney, Erin M; Morrissey, Christy A; Headley, John V; Peru, Kerry M; Liber, Karsten

2017-11-01

Extensive agricultural use of neonicotinoid insecticide products has resulted in the presence of neonicotinoid mixtures in surface waters worldwide. Although many aquatic insect species are known to be sensitive to neonicotinoids, the impact of neonicotinoid mixtures is poorly understood. In the present study, the cumulative toxicities of binary and ternary mixtures of select neonicotinoids (imidacloprid, clothianidin, and thiamethoxam) were characterized under acute (96-h) exposure scenarios using the larval midge Chironomus dilutus as a representative aquatic insect species. Using the MIXTOX approach, predictive parametric models were fitted and statistically compared with observed toxicity in subsequent mixture tests. Single-compound toxicity tests yielded median lethal concentration (LC50) values of 4.63, 5.93, and 55.34 μg/L for imidacloprid, clothianidin, and thiamethoxam, respectively. Because of the similar modes of action of neonicotinoids, concentration-additive cumulative mixture toxicity was the predicted model. However, we found that imidacloprid-clothianidin mixtures demonstrated response-additive dose-level-dependent synergism, clothianidin-thiamethoxam mixtures demonstrated concentration-additive synergism, and imidacloprid-thiamethoxam mixtures demonstrated response-additive dose-ratio-dependent synergism, with toxicity shifting from antagonism to synergism as the relative concentration of thiamethoxam increased. Imidacloprid-clothianidin-thiamethoxam ternary mixtures demonstrated response-additive synergism. These results indicate that, under acute exposure scenarios, the toxicity of neonicotinoid mixtures to C. dilutus cannot be predicted using the common assumption of additive joint activity. Indeed, the overarching trend of synergistic deviation emphasizes the need for further research into the ecotoxicological effects of neonicotinoid insecticide mixtures in field settings, the development of better toxicity models for neonicotinoid mixture exposures, and the consideration of mixture effects when setting water quality guidelines for this class of pesticides. Environ Toxicol Chem 2017;36:3091-3101. © 2017 SETAC. © 2017 SETAC.

The effects of age and step length on joint kinematics and kinetics of large out-and-back steps.

PubMed

Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B

2008-06-01

Maximum step length (MSL) is a clinical test that has been shown to correlate with age, various measures of fall risk, and knee and hip joint extension speed, strength, and power capacities, but little is known about the kinematics and kinetics of the large out-and-back step utilized. Body motions and ground reaction forces were recorded for 11 unimpaired younger and 10 older women while attaining maximum step length. Joint kinematics and kinetics were calculated using inverse dynamics. The effects of age group and step length on the biomechanics of these large out-and-back steps were determined. Maximum step length was 40% greater in the younger than in the older women (P<0.0001). Peak knee and hip, but not ankle, angle, velocity, moment, and power were generally greater for younger women and longer steps. After controlling for age group, step length generally explained significant additional variance in hip and torso kinematics and kinetics (incremental R2=0.09-0.37). The young reached their peak knee extension moment immediately after landing of the step out, while the old reached their peak knee extension moment just before the return step liftoff (P=0.03). Maximum step length is strongly associated with hip kinematics and kinetics. Delays in peak knee extension moment that appear to be unrelated to step length, may indicate a reduced ability of older women to rapidly apply force to the ground with the stepping leg and thus arrest the momentum of a fall.

The effects of age and step length on joint kinematics and kinetics of large out-and-back steps

PubMed Central

Schulz, Brian W.; Ashton-Miller, James A.; Alexander, Neil B.

2008-01-01

Background Maximum Step Length is a clinical test that has been shown to correlate with age, various measures of fall risk, and knee and hip joint extension speed, strength, and power capacities, but little is known about the kinematics and kinetics of the large out-and-back step utilized. Methods Body motions and ground reaction forces were recorded for 11 unimpaired younger and 10 older women while attaining Maximum Step Length. Joint kinematics and kinetics were calculated using inverse dynamics. The effects of age group and step length on the biomechanics of these large out-and-back steps were determined. Findings Maximum Step Length was 40% greater in the younger than in the older women (p<0.0001). Peak knee and hip, but not ankle, angle, velocity, moment, and power were generally greater for younger women and longer steps. After controlling for age group, step length generally explained significant additional variance in hip and torso kinematics and kinetics (incremental R2=0.09–0.37). The young reached their peak knee extension moment immediately after landing of the step out, while the old reached their peak knee extension moment just before the return step lift off (p=0.03). Interpretation Maximum Step Length is strongly associated with hip kinematics and kinetics. Delays in peak knee extension moment that appear to be unrelated to step length, may indicate a reduced ability of older women to rapidly apply force to the ground with the stepping leg and thus arrest the momentum of a fall. PMID:18308435

Quantitative analyses of cell behaviors underlying notochord formation and extension in mouse embryos.

PubMed

Sausedo, R A; Schoenwolf, G C

1994-05-01

Formation and extension of the notochord (i.e., notogenesis) is one of the earliest and most obvious events of axis development in vertebrate embryos. In birds and mammals, prospective notochord cells arise from Hensen's node and come to lie beneath the midline of the neural plate. Throughout the period of neurulation, the notochord retains its close spatial relationship with the developing neural tube and undergoes rapid extension in concert with the overlying neuroepithelium. In the present study, we examined notochord development quantitatively in mouse embryos. C57BL/6 mouse embryos were collected at 8, 8.5, 9, 9.5, and 10 days of gestation. They were then embedded in paraffin and sectioned transversely. Serial sections from 21 embryos were stained with Schiff's reagent according to the Feulgen-Rossenbeck procedure and used for quantitative analyses of notochord extension. Quantitative analyses revealed that extension of the notochord involves cell division within the notochord proper and cell rearrangement within the notochordal plate (the immediate precursor of the notochord). In addition, extension of the notochord involves cell accretion, that is, the addition of cells to the notochord's caudal end, a process that involves considerable cell rearrangement at the notochordal plate-node interface. Extension of the mouse notochord occurs similarly to that described previously for birds (Sausedo and Schoenwolf, 1993 Anat. Rec. 237:58-70). That is, in both birds (i.e., quail and chick) and mouse embryos, notochord extension involves cell division, cell rearrangement, and cell accretion. Thus higher vertebrates utilize similar morphogenetic movements to effect notogenesis.

Laboratory diagnosis of Ebola virus disease and corresponding biosafety considerations in the China Ebola Treatment Center.

PubMed

Huang, Qing; Fu, Wei-Ling; You, Jian-Ping; Mao, Qing

2016-10-01

Ebola virus disease (EVD), caused by Ebola virus (EBOV), is a potent acute infectious disease with a high case-fatality rate. Etiological and serological EBOV detection methods, including techniques that involve the detection of the viral genome, virus-specific antigens and anti-virus antibodies, are standard laboratory diagnostic tests that facilitate confirmation or exclusion of EBOV infection. In addition, routine blood tests, liver and kidney function tests, electrolytes and coagulation tests and other diagnostic examinations are important for the clinical diagnosis and treatment of EVD. Because of the viral load in body fluids and secretions from EVD patients, all body fluids are highly contagious. As a result, biosafety control measures during the collection, transport and testing of clinical specimens obtained from individuals scheduled to undergo EBOV infection testing (including suspected, probable and confirmed cases) are crucial. This report has been generated following extensive work experience in the China Ebola Treatment Center (ETC) in Liberia and incorporates important information pertaining to relevant diagnostic standards, clinical significance, operational procedures, safety controls and other issues related to laboratory testing of EVD. Relevant opinions and suggestions are presented in this report to provide contextual awareness associated with the development of standards and/or guidelines related to EVD laboratory testing.

Bench-Scale Trace Contaminant Testing of SA9T at Ambient and Reduced Pressure Conditions

NASA Technical Reports Server (NTRS)

Broerman, Craig; Sweterlitsch, Jeff

2011-01-01

A principal concern for air revitalization technology in a closed loop system is the capability to control carbon dioxide (CO2) and humidity (H2O). An amine based sorbent technology, SA9T, has been evaluated for use in this application and several programs are evaluating it for use in both cabin and space suit applications. While the CO2 and H2O performance of the sorbent has been tested extensively, the question of how trace contaminants impact performance requires further evaluation. This paper presents experimental results of bench-scale SA9T testing that was performed under a variety of test conditions and with several different trace contaminants. Tests were conducted to determine if the capacity of the SA9T media to sufficiently remove CO2 and H2O is compromised after exposure to a fully saturated trace contaminant at ambient conditions. Tests also were conducted to evaluate the performance of SA9T at ambient conditions in a continuous 30-day test with a mixed trace contaminant stream. In addition, testing also evaluated the impact of CO2 and H2O removal performance at suit loop pressures (29.6 KPa/4.3 psia) during cyclic operation with a constant inlet contaminant load.

All-season flash flood forecasting system for real-time operations

USDA-ARS?s Scientific Manuscript database

Flash floods can cause extensive damage to both life and property, especially because they are difficult to predict. Flash flood prediction requires high-resolution meteorologic observations and predictions, as well as calibrated hydrologic models in addition to extensive data handling. We have de...

Maximum acceptable weight of lift reflects peak lumbosacral extension moments in a functional capacity evaluation test using free style, stoop and squat lifting.

PubMed

Kuijer, P P F M; van Oostrom, S H; Duijzer, K; van Dieën, J H

2012-01-01

It is unclear whether the maximum acceptable weight of lift (MAWL), a common psychophysical method, reflects joint kinetics when different lifting techniques are employed. In a within-participants study (n = 12), participants performed three lifting techniques--free style, stoop and squat lifting from knee to waist level--using the same dynamic functional capacity evaluation lifting test to assess MAWL and to calculate low back and knee kinetics. We assessed which knee and back kinetic parameters increased with the load mass lifted, and whether the magnitudes of the kinetic parameters were consistent across techniques when lifting MAWL. MAWL was significantly different between techniques (p = 0.03). The peak lumbosacral extension moment met both criteria: it had the highest association with the load masses lifted (r > 0.9) and was most consistent between the three techniques when lifting MAWL (ICC = 0.87). In conclusion, MAWL reflects the lumbosacral extension moment across free style, stoop and squat lifting in healthy young males, but the relation between the load mass lifted and lumbosacral extension moment is different between techniques. Tests of maximum acceptable weight of lift (MAWL) from knee to waist height are used to assess work capacity of individuals with low-back disorders. This article shows that the MAWL reflects the lumbosacral extension moment across free style, stoop and squat lifting in healthy young males, but the relation between the load mass lifted and lumbosacral extension moment is different between techniques. This suggests that standardisation of lifting technique used in tests of the MAWL would be indicated if the aim is to assess the capacity of the low back.

Spread of extensively resistant VIM-2-positive ST235 Pseudomonas aeruginosa in Belarus, Kazakhstan, and Russia: a longitudinal epidemiological and clinical study.

PubMed

Edelstein, Mikhail V; Skleenova, Elena N; Shevchenko, Oksana V; D'souza, Jimson W; Tapalski, Dmitry V; Azizov, Ilya S; Sukhorukova, Marina V; Pavlukov, Roman A; Kozlov, Roman S; Toleman, Mark A; Walsh, Timothy R

2013-10-01

Multidrug-resistant and extensively-drug-resistant Pseudomonas aeruginosa are increasing therapeutic challenges worldwide. We did a longitudinal epidemiological and clinical study of extensively-drug-resistant P aeruginosa in Belarus, Kazakhstan, and Russia. The study was done in three prospectively defined phases: Jan 1, 2002-Dec 31, 2004; Jan 1, 2006-Dec 31, 2007; and Jan 1, 2008-Dec 31, 2010. The first two phases were in Russia only. All consecutive, non-duplicate, nosocomial isolates and case report forms were sent to the coordinating centre (Institute of Antimicrobial Chemotherapy, Smolensk, Russia), where species reidentification, susceptibility testing, and molecular typing of isolates were done. We did susceptibility testing by agar dilution. The presence of metallo-β-lactamase (MBL) genes was established by PCR and sequencing, and class 1 integrons containing MBL gene cassettes were analysed by the PCR restriction fragment length polymorphism approach. Strain relatedness was analysed by multiple loci variable-number tandem-repeat (VNTR) analysis (at six VNTR loci) and multilocus sequence typing. In 2002-04, 628 of 1053 P aeruginosa isolates were insusceptible to carbapenems and 47 (4.5%) possessed MBLs. In 2006-07, 584 of 787 isolates were insusceptible to carbapenems and 160 (20.3%) possessed MBLs. In 2008-10, 1238 of 1643 Russian P aeruginosa isolates were insusceptible to carbapenems and 471 (28.7%) possessed MBLs. Additionally, the 32 P aeruginosa isolates from Belarus and Kazakhstan were all carbapenem insusceptible and all possessed MBLs. More than 96% of MBL-positive P aeruginosa isolates were resistant to all antibiotics except colistin (ie, extensively drug resistant), and, in 2010, 5·9% were resistant to colistin. 685 (96.5%) of 710 MBL-positive P aeruginosa belonged to ST235. bla(VIM-2) genes were detected in 707 (99.6%) of 710 MBL-positive isolates. Extensively-drug-resistant ST235 P aeruginosa has rapidly spread throughout Russia and into Belarus and Kazakhstan via clonal dissemination. Increases in the use of colistin will probably result in further spread of ST235 P aeruginosa resistant to all drugs. HEFC, Ministry of Health of the Russian Federation, Government of the Republic of Belarus, Government of the Republic of Kazakhstan, European Union, Medical Research Council UK-Canada partnership. Copyright © 2013 Elsevier Ltd. All rights reserved.

Efficacy of Vismodegib (Erivedge) for Basal Cell Carcinoma Involving the Orbit and Periocular Area.

PubMed

Demirci, Hakan; Worden, Francis; Nelson, Christine C; Elner, Victor M; Kahana, Alon

2015-01-01

Evaluate the effectiveness of vismodegib in the management of basal cell carcinoma with orbital extension and/or extensive periocular involvement. Retrospective chart review of 6 consecutive patients with biopsy-proven orbital basal cell carcinoma and 2 additional patients with extensive periocular basal cell carcinoma who were treated with oral vismodegib (150 mg/day) was performed. Basal cell carcinoma extended in the orbit in 6 of 8 patients (involving orbital bones in 1 patient), and 2 of 8 patients had extensive periocular involvement (1 with basal cell nevus syndrome). Vismodegib therapy was the only treatment in 6 patients, off-label neoadjuvant in 1 patient, and adjuvant treatment in 1 patient. Orbital tumors in all 4 patients who received vismodegib as sole treatment showed partial response with a mean 83% shrinkage in tumor size after a median of 7 months of therapy. In the 2 patients receiving vismodegib as neoadjuvant or adjuvant therapies, there was complete response after a median of 7 months of therapy and no evidence of clinical recurrence after discontinuing therapy for a median of 15 months. The 2 patients with extensive periocular involvement experienced complete clinical response after a median 14 months of treatment. During treatment, the most common side effects were muscle spasm (75%) followed by alopecia (50%), dysgeusia (25%), dysosmia, and episodes of diarrhea and constipation (13%). Basal cell carcinoma with orbital extension and extensive periocular involvement responds to vismodegib therapy. The long-term prognosis remains unknown, and additional prospective studies are indicated.

DPOD2005: An extension of ITRF2005 for Precise Orbit Determination

NASA Astrophysics Data System (ADS)

Willis, P.; Ries, J. C.; Zelensky, N. P.; Soudarin, L.; Fagard, H.; Pavlis, E. C.; Lemoine, F. G.

2009-09-01

For Precise Orbit Determination of altimetry missions, we have computed a data set of DORIS station coordinates defined for specific time intervals called DPOD2005. This terrestrial reference set is an extension of ITRF2005. However, it includes all new DORIS stations and is more reliable, as we disregard stations with large velocity formal errors as they could contaminate POD computations in the near future. About 1/4 of the station coordinates need to be defined as they do not appear in the original ITRF2005 realization. These results were verified with available DORIS and GPS results, as the integrity of DPOD2005 is almost as critical as its accuracy. Besides station coordinates and velocities, we also provide additional information such as periods for which DORIS data should be disregarded for specific DORIS stations, and epochs of coordinate and velocity discontinuities (related to either geophysical events, equipment problem or human intervention). The DPOD model was tested for orbit determination for TOPEX/Poseidon (T/P), Jason-1 and Jason-2. Test results show DPOD2005 offers improvement over the original ITRF2005, improvement that rapidly and significantly increases after 2005. Improvement is also significant for the early T/P cycles indicating improved station velocities in the DPOD2005 model and a more complete station set. Following 2005 the radial accuracy and centering of the ITRF2005-original orbits rapidly degrades due to station loss.

Water-tunnel study results of a TF/A-18 and F/A-18 canopy flow visualization

NASA Technical Reports Server (NTRS)

Johnson, Steven A.; Fisher, David F.

1990-01-01

A water tunnel study examining the influence of canopy shape on canopy and leading edge extension flow patterns was initiated. The F/A-18 single-place canopy model and the TF/A-18 two place canopy model were the study subjects. Plan view and side view photographs showing the flow patterns created by injected colored dye are presented for 0 deg and 5 deg sideslip angles. Photographs taken at angle of attack and sideslip conditions correspond to test departure points found in flight test. Flight experience has shown that the TF/A-18 airplane departs in regions where the F/A-18 airplane is departure-resistant. The study results provide insight into the differences in flow patterns which may influence the resulting aerodynamics of the TF/A-18 and F/A-18 aircraft. It was found that at 0 deg sideslip, the TF/A-18 model has more downward flow on the sides of the canopy than the F/A-18 model. This could be indicative of flow from the leading edge extension (LEX) vortexes impinging on the sides of the wider TF/A-18 canopy. In addition, the TF/A-18 model has larger areas of asymmetric separated and unsteady flow on the LEXs and fuselage, possibly indicating a lateral and directional destabilizing effect at the conditions studied.

An Extension and Test of Sutherland's Concept of Differential Social Organization: The Geographic Clustering of Japanese Suicide and Homicide Rates

ERIC Educational Resources Information Center

Baller, Robert D.; Shin, Dong-Joon; Richardson, Kelly K.

2005-01-01

In an effort to explain the spatial patterning of violence, we expanded Sutherland's (1947) concept of differential social organization to include the level of deviance exhibited by neighboring areas. To test the value of this extension, the geographic clustering of Japanese suicide and homicide rates is assessed using 1985 and 1995 data for…

Developing Ultra Reliable Life Support for the Moon and Mars

NASA Technical Reports Server (NTRS)

Jones, Harry W.

2009-01-01

Recycling life support systems can achieve ultra reliability by using spares to replace failed components. The added mass for spares is approximately equal to the original system mass, provided the original system reliability is not very low. Acceptable reliability can be achieved for the space shuttle and space station by preventive maintenance and by replacing failed units, However, this maintenance and repair depends on a logistics supply chain that provides the needed spares. The Mars mission must take all the needed spares at launch. The Mars mission also must achieve ultra reliability, a very low failure rate per hour, since it requires years rather than weeks and cannot be cut short if a failure occurs. Also, the Mars mission has a much higher mass launch cost per kilogram than shuttle or station. Achieving ultra reliable space life support with acceptable mass will require a well-planned and extensive development effort. Analysis must define the reliability requirement and allocate it to subsystems and components. Technologies, components, and materials must be designed and selected for high reliability. Extensive testing is needed to ascertain very low failure rates. Systems design should segregate the failure causes in the smallest, most easily replaceable parts. The systems must be designed, produced, integrated, and tested without impairing system reliability. Maintenance and failed unit replacement should not introduce any additional probability of failure. The overall system must be tested sufficiently to identify any design errors. A program to develop ultra reliable space life support systems with acceptable mass must start soon if it is to produce timely results for the moon and Mars.

Site characterization in densely fractured dolomite: Comparison of methods

USGS Publications Warehouse

Muldoon, M.; Bradbury, K.R.

2005-01-01

One of the challenges in characterizing fractured-rock aquifers is determining whether the equivalent porous medium approximation is valid at the problem scale. Detailed hydrogeologic characterization completed at a small study site in a densely fractured dolomite has yielded an extensive data set that was used to evaluate the utility of the continuum and discrete-fracture approaches to aquifer characterization. There are two near-vertical sets of fractures at the site; near-horizontal bedding-plane partings constitute a third fracture set. Eighteen boreholes, including five coreholes, were drilled to a depth of ???10.6 m. Borehole geophysical logs revealed several laterally extensive horizontal fractures and dissolution zones. Flowmeter and short-interval packer testing identified which of these features were hydraulically important. A monitoring system, consisting of short-interval piezometers and multilevel samplers, was designed to monitor four horizontal fractures and two dissolution zones. The resulting network consisted of >70 sampling points and allowed detailed monitoring of head distributions in three dimensions. Comparison of distributions of hydraulic head - and hydraulic conductivity determined by these two approaches suggests that even in a densely fractured-carbonate aquifer, a characterization approach using traditional long-interval monitoring wells is inadequate to characterize ground water movement for the purposes of regulatory monitoring or site remediation. In addition, traditional multiwell pumping tests yield an average or bulk hydraulic conductivity that is not adequate for predicting rapid ground water travel times through the fracture network, and the pumping test response does not appear to be an adequate tool for assessing whether the porous medium approximation is valid. Copyright ?? 2005 National Ground Water Association.

An improved correlation procedure for subsize and full-size Charpy impact specimen data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sokolov, M.A.; Alexander, D.J.

1997-03-01

The possibility of using subsize specimens to monitor the properties of reactor pressure vessel steels is receiving increasing attention for light-water reactor plant life extension. This potential results from the possibility of cutting samples of small volume form the internal surface of the pressure vessel for determination of the actual properties of the operating pressure vessel. In addition, plant life extension will require supplemental data that cannot be provided by existing surveillance programs. Testing of subsize specimens manufactured from broken halves of previously tested surveillance Charpy specimens offers an attractive means of extending existing surveillance programs. Using subsize Charpy V-notch-typemore » specimens requires the establishment of a specimen geometry that is adequate to obtain a ductile-to-brittle transition curve similar to that obtained from full-size specimens, and the development of correlations for transition temperature and upper-shelf energy (USE) level between subsize and full-size specimens. Five different geometries of subsize specimens were selected for testing and evaluation. The specimens were made from several types of pressure vessel steels with a wide range of yield strengths, transition temperatures, and USEs. The effects of specimen dimensions, including notch depth, angle, and radius, have been studied. The correlations of transition temperatures determined from different types of subsize specimens and the full-size specimens are presented. A new procedure for transforming data from subsize specimens is developed. The transformed data are in good agreement with data from full-size specimens for materials that have USE levels less than 200 J.« less

Site characterization in densely fractured dolomite: comparison of methods.

PubMed

Muldoon, Maureen; Bradbury, Ken R

2005-01-01

One of the challenges in characterizing fractured-rock aquifers is determining whether the equivalent porous medium approximation is valid at the problem scale. Detailed hydrogeologic characterization completed at a small study site in a densely fractured dolomite has yielded an extensive data set that was used to evaluate the utility of the continuum and discrete-fracture approaches to aquifer characterization. There are two near-vertical sets of fractures at the site; near-horizontal bedding-plane partings constitute a third fracture set. Eighteen boreholes, including five coreholes, were drilled to a depth of approximately 10.6 m. Borehole geophysical logs revealed several laterally extensive horizontal fractures and dissolution zones. Flowmeter and short-interval packer testing identified which of these features were hydraulically important. A monitoring system, consisting of short-interval piezometers and multilevel samplers, was designed to monitor four horizontal fractures and two dissolution zones. The resulting network consisted of >70 sampling points and allowed detailed monitoring of head distributions in three dimensions. Comparison of distributions of hydraulic head and hydraulic conductivity determined by these two approaches suggests that even in a densely fractured-carbonate aquifer, a characterization approach using traditional long-interval monitoring wells is inadequate to characterize ground water movement for the purposes of regulatory monitoring or site remediation. In addition, traditional multiwell pumping tests yield an average or bulk hydraulic conductivity that is not adequate for predicting rapid ground water travel times through the fracture network, and the pumping test response does not appear to be an adequate tool for assessing whether the porous medium approximation is valid.

Use of a probabilistic neural network to reduce costs of selecting construction rock

USGS Publications Warehouse

Singer, Donald A.; Bliss, James D.

2003-01-01

Rocks used as construction aggregate in temperate climates deteriorate to differing degrees because of repeated freezing and thawing. The magnitude of the deterioration depends on the rock's properties. Aggregate, including crushed carbonate rock, is required to have minimum geotechnical qualities before it can be used in asphalt and concrete. In order to reduce chances of premature and expensive repairs, extensive freeze-thaw tests are conducted on potential construction rocks. These tests typically involve 300 freeze-thaw cycles and can take four to five months to complete. Less time consuming tests that (1) predict durability as well as the extended freeze-thaw test or that (2) reduce the number of rocks subject to the extended test, could save considerable amounts of money. Here we use a probabilistic neural network to try and predict durability as determined by the freeze-thaw test using four rock properties measured on 843 limestone samples from the Kansas Department of Transportation. Modified freeze-thaw tests and less time consuming specific gravity (dry), specific gravity (saturated), and modified absorption tests were conducted on each sample. Durability factors of 95 or more as determined from the extensive freeze-thaw tests are viewed as acceptable—rocks with values below 95 are rejected. If only the modified freeze-thaw test is used to predict which rocks are acceptable, about 45% are misclassified. When 421 randomly selected samples and all four standardized and scaled variables were used to train aprobabilistic neural network, the rate of misclassification of 422 independent validation samples dropped to 28%. The network was trained so that each class (group) and each variable had its own coefficient (sigma). In an attempt to reduce errors further, an additional class was added to the training data to predict durability values greater than 84 and less than 98, resulting in only 11% of the samples misclassified. About 43% of the test data was classed by the neural net into the middle group—these rocks should be subject to full freeze-thaw tests. Thus, use of the probabilistic neural network would meanthat the extended test would only need be applied to 43% of the samples, and 11% of the rocks classed as acceptable would fail early.

The Role of Extensive Reading in the Development of Phonological Processing

ERIC Educational Resources Information Center

Nisanci, Sinan

2017-01-01

The present study aims to investigate the role of extensive reading in the acquisition of implicit phonological knowledge. Through extensive exposure to print, L2 learners can improve their phonological processing skills, and this could contribute to their word recognition fluency. On the basis of the Oxford Placement Test, 30 9th graders and 30…

Classroom Activity Connections: Lessons from Fluorescence

ERIC Educational Resources Information Center

MacCormac, Aoife; O'Brien, Emma; O'Kennedy, Richard

2010-01-01

This Classroom Activity Connections paper describes an extension to the "JCE" Classroom Activity #68 "Turning on the Light". A number of additional common items that display fluorescence under UV light are described, including fruits, vegetables, and seashells. Two classroom extensions on fluorescence are also described. From these activities,…

Extension Resources for International Trade

ERIC Educational Resources Information Center

Seal, Susan D.

2016-01-01

With the opening of additional trade partnerships, the reduction of global transportation and communication costs, and the increase in demand for U.S. agricultural products and services, international trade is an area of great importance to more and more Extension clients and stakeholders. This article provides information about the primary…

26 CFR 1.381(c)(5)-1 - Inventories.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the dollar-value method, use the double-extension method, pool under the natural business unit method... double-extension method, pool under the natural business unit method, and value annual inventory... natural business unit method while P corporation pools under the multiple pool method. In addition, O...

26 CFR 1.381(c)(5)-1 - Inventories.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the dollar-value method, use the double-extension method, pool under the natural business unit method... double-extension method, pool under the natural business unit method, and value annual inventory... natural business unit method while P corporation pools under the multiple pool method. In addition, O...

77 FR 1507 - Agency Information Collection Activities: Extension of a Currently Approved Collection; Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

... Grants Program is divided into sections that pertain to the different types of activities that... DEPARTMENT OF JUSTICE [OMB Number 1122-0003] Agency Information Collection Activities: Extension... Affairs, Attention Department of Justice Desk Officer, Washington, DC 20503. Additionally, comments may be...

Improving Generation Y Volunteerism in Extension Programs

ERIC Educational Resources Information Center

Andrews, Kevin B.; Lockett, Landry L.

2013-01-01

Members of Generation Y have many positive attributes that make them attractive to Extension volunteer administrators as a potential source of labor. However, they think differently, have unique needs, require new management styles, and have less tolerance for unpleasant working conditions than previous generations. Additionally, they are engaged…

77 FR 15115 - Agency Information Collection Activities: Extension, without Change, of an Existing Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-14

..., mechanical, or other technological collection techniques or other forms of information technology, e.g...; or inquiries for additional information should be directed to: John Ramsay, Forms Program Manager, U... Information Collection Activities: Extension, without Change, of an Existing Information Collection; Comment...

77 FR 37063 - Agency Information Collection Activities: Extension, Without Change, of a Currently Approved...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... information technology, e.g., permitting electronic submission of responses. Overview of This Information... additional information should be directed to: John Ramsay, Program (Forms) Manager, U.S. Immigration and... Information Collection Activities: Extension, Without Change, of a Currently Approved Collection; Comment...

The effects of certain enzymes on the rheology of dough and the quality characteristics of bread prepared from wheat meal.

PubMed

Altınel, Burak; Ünal, S Sezgin

2017-05-01

This study was carried out to evaluate the effects of amyloglucosidase, glucose oxidase, hemicellulase (mainly consist of endo-1,4-β-xylanase), cellulase, lipase, and the combination of phospholipase and hemicellulase (phospholipase + hemicellulase) on the extensographic properties of dough and the quality characteristics of bread prepared from wheat meal. The enzymes were added separately in two different amounts. The addition of glucose oxidase (at 0.0003-0.001%) caused a significant decrease in the resistance to extension, ratio of resistance to extensibility and energy values of the wheat meal dough compared with the control dough. The addition of hemicellulase (at 0.001-0.005%) and phospholipase + hemicellulase (at 0.0006-0.0009%) also improved the wheat meal dough rheology by reducing the resistance to extension and the ratio of resistance to extensibility. Glucose oxidase (at 0.0003-0.001%), hemicellulase (at 0.001-0.005%) and phospholipase + hemicellulase (at 0.0006-0.0009%) addition improved the specific volume of wheat meal bread compared with the control bread. Increasing the dosage of glucose oxidase from 0.0003 to 0.001% caused a further increase in the specific volume of wheat meal bread. The addition of hemicellulase (at 0.001-0.005%) caused a significant decrease in the baking loss and an increase in the moisture content of wheat meal bread compared with the control bread. The addition of amyloglucosidase (at 0.000875-0.001%), lipase (at 0.0002-0.001%) and cellulase (at 0.0003-0.0005%) did not considerably affected the dough rheological and the quality characteristics of wheat meal bread.

Solid Propulsion Systems, Subsystems, and Components Service Life Extension

NASA Technical Reports Server (NTRS)

Hundley, Nedra H.; Jones, Connor

2011-01-01

The service life extension of solid propulsion systems, subsystems, and components will be discussed based on the service life extension of the Space Transportation System Reusable Solid Rocket Motor (RSRM) and Booster Separation Motors (BSM). The RSRM is certified for an age life of five years. In the aftermath of the Columbia accident there were a number of motors that were approaching the end of their five year service life certification. The RSRM Project initiated an assessment to determine if the service life of these motors could be extended. With the advent of the Constellation Program, a flight test was proposed that would utilize one of the RSRMs which had been returned from the launch site due to the expiration of its five year service life certification and twelve surplus Chemical Systems Division BSMs which had exceeded their eight year service life. The RSRM age life tracking philosophy which establishes when the clock starts for age life tracking will be described. The role of the following activities in service life extension will be discussed: subscale testing, accelerated aging, dissecting full scale aged hardware, static testing full scale aged motors, data mining industry data, and using the fleet leader approach. The service life certification and extension of the BSMs will also be presented.