Science.gov

Sample records for addition sensitivity analysis

  1. Sensitivity analysis of geometric errors in additive manufacturing medical models.

    PubMed

    Pinto, Jose Miguel; Arrieta, Cristobal; Andia, Marcelo E; Uribe, Sergio; Ramos-Grez, Jorge; Vargas, Alex; Irarrazaval, Pablo; Tejos, Cristian

    2015-03-01

    Additive manufacturing (AM) models are used in medical applications for surgical planning, prosthesis design and teaching. For these applications, the accuracy of the AM models is essential. Unfortunately, this accuracy is compromised due to errors introduced by each of the building steps: image acquisition, segmentation, triangulation, printing and infiltration. However, the contribution of each step to the final error remains unclear. We performed a sensitivity analysis comparing errors obtained from a reference with those obtained modifying parameters of each building step. Our analysis considered global indexes to evaluate the overall error, and local indexes to show how this error is distributed along the surface of the AM models. Our results show that the standard building process tends to overestimate the AM models, i.e. models are larger than the original structures. They also show that the triangulation resolution and the segmentation threshold are critical factors, and that the errors are concentrated at regions with high curvatures. Errors could be reduced choosing better triangulation and printing resolutions, but there is an important need for modifying some of the standard building processes, particularly the segmentation algorithms. PMID:25649961

  2. Sensitivity Analysis in Engineering

    NASA Technical Reports Server (NTRS)

    Adelman, Howard M. (Compiler); Haftka, Raphael T. (Compiler)

    1987-01-01

    The symposium proceedings presented focused primarily on sensitivity analysis of structural response. However, the first session, entitled, General and Multidisciplinary Sensitivity, focused on areas such as physics, chemistry, controls, and aerodynamics. The other four sessions were concerned with the sensitivity of structural systems modeled by finite elements. Session 2 dealt with Static Sensitivity Analysis and Applications; Session 3 with Eigenproblem Sensitivity Methods; Session 4 with Transient Sensitivity Analysis; and Session 5 with Shape Sensitivity Analysis.

  3. Sensitivity Test Analysis

    1992-02-20

    SENSIT,MUSIG,COMSEN is a set of three related programs for sensitivity test analysis. SENSIT conducts sensitivity tests. These tests are also known as threshold tests, LD50 tests, gap tests, drop weight tests, etc. SENSIT interactively instructs the experimenter on the proper level at which to stress the next specimen, based on the results of previous responses. MUSIG analyzes the results of a sensitivity test to determine the mean and standard deviation of the underlying population bymore » computing maximum likelihood estimates of these parameters. MUSIG also computes likelihood ratio joint confidence regions and individual confidence intervals. COMSEN compares the results of two sensitivity tests to see if the underlying populations are significantly different. COMSEN provides an unbiased method of distinguishing between statistical variation of the estimates of the parameters of the population and true population difference.« less

  4. LISA Telescope Sensitivity Analysis

    NASA Technical Reports Server (NTRS)

    Waluschka, Eugene; Krebs, Carolyn (Technical Monitor)

    2001-01-01

    The results of a LISA telescope sensitivity analysis will be presented, The emphasis will be on the outgoing beam of the Dall-Kirkham' telescope and its far field phase patterns. The computed sensitivity analysis will include motions of the secondary with respect to the primary, changes in shape of the primary and secondary, effect of aberrations of the input laser beam and the effect the telescope thin film coatings on polarization. An end-to-end optical model will also be discussed.

  5. Sensitivity Analysis Without Assumptions

    PubMed Central

    VanderWeele, Tyler J.

    2016-01-01

    Unmeasured confounding may undermine the validity of causal inference with observational studies. Sensitivity analysis provides an attractive way to partially circumvent this issue by assessing the potential influence of unmeasured confounding on causal conclusions. However, previous sensitivity analysis approaches often make strong and untestable assumptions such as having an unmeasured confounder that is binary, or having no interaction between the effects of the exposure and the confounder on the outcome, or having only one unmeasured confounder. Without imposing any assumptions on the unmeasured confounder or confounders, we derive a bounding factor and a sharp inequality such that the sensitivity analysis parameters must satisfy the inequality if an unmeasured confounder is to explain away the observed effect estimate or reduce it to a particular level. Our approach is easy to implement and involves only two sensitivity parameters. Surprisingly, our bounding factor, which makes no simplifying assumptions, is no more conservative than a number of previous sensitivity analysis techniques that do make assumptions. Our new bounding factor implies not only the traditional Cornfield conditions that both the relative risk of the exposure on the confounder and that of the confounder on the outcome must satisfy but also a high threshold that the maximum of these relative risks must satisfy. Furthermore, this new bounding factor can be viewed as a measure of the strength of confounding between the exposure and the outcome induced by a confounder. PMID:26841057

  6. Sensitivity analysis of SPURR

    SciTech Connect

    Witholder, R.E.

    1980-04-01

    The Solar Energy Research Institute has conducted a limited sensitivity analysis on a System for Projecting the Utilization of Renewable Resources (SPURR). The study utilized the Domestic Policy Review scenario for SPURR agricultural and industrial process heat and utility market sectors. This sensitivity analysis determines whether variations in solar system capital cost, operation and maintenance cost, and fuel cost (biomass only) correlate with intuitive expectations. The results of this effort contribute to a much larger issue: validation of SPURR. Such a study has practical applications for engineering improvements in solar technologies and is useful as a planning tool in the R and D allocation process.

  7. RESRAD parameter sensitivity analysis

    SciTech Connect

    Cheng, J.J.; Yu, C.; Zielen, A.J.

    1991-08-01

    Three methods were used to perform a sensitivity analysis of RESRAD code input parameters -- enhancement of RESRAD by the Gradient Enhanced Software System (GRESS) package, direct parameter perturbation, and graphic comparison. Evaluation of these methods indicated that (1) the enhancement of RESRAD by GRESS has limitations and should be used cautiously, (2) direct parameter perturbation is tedious to implement, and (3) the graphics capability of RESRAD 4.0 is the most direct and convenient method for performing sensitivity analyses. This report describes procedures for implementing these methods and presents a comparison of results. 3 refs., 9 figs., 8 tabs.

  8. Scaling in sensitivity analysis

    USGS Publications Warehouse

    Link, W.A.; Doherty, P.F., Jr.

    2002-01-01

    Population matrix models allow sets of demographic parameters to be summarized by a single value 8, the finite rate of population increase. The consequences of change in individual demographic parameters are naturally measured by the corresponding changes in 8; sensitivity analyses compare demographic parameters on the basis of these changes. These comparisons are complicated by issues of scale. Elasticity analysis attempts to deal with issues of scale by comparing the effects of proportional changes in demographic parameters, but leads to inconsistencies in evaluating demographic rates. We discuss this and other problems of scaling in sensitivity analysis, and suggest a simple criterion for choosing appropriate scales. We apply our suggestions to data for the killer whale, Orcinus orca.

  9. LISA Telescope Sensitivity Analysis

    NASA Technical Reports Server (NTRS)

    Waluschka, Eugene; Krebs, Carolyn (Technical Monitor)

    2002-01-01

    The Laser Interferometer Space Antenna (LISA) for the detection of Gravitational Waves is a very long baseline interferometer which will measure the changes in the distance of a five million kilometer arm to picometer accuracies. As with any optical system, even one with such very large separations between the transmitting and receiving, telescopes, a sensitivity analysis should be performed to see how, in this case, the far field phase varies when the telescope parameters change as a result of small temperature changes.

  10. Sensitivity testing and analysis

    SciTech Connect

    Neyer, B.T.

    1991-01-01

    New methods of sensitivity testing and analysis are proposed. The new test method utilizes Maximum Likelihood Estimates to pick the next test level in order to maximize knowledge of both the mean, {mu}, and the standard deviation, {sigma} of the population. Simulation results demonstrate that this new test provides better estimators (less bias and smaller variance) of both {mu} and {sigma} than the other commonly used tests (Probit, Bruceton, Robbins-Monro, Langlie). A new method of analyzing sensitivity tests is also proposed. It uses the Likelihood Ratio Test to compute regions of arbitrary confidence. It can calculate confidence regions, for {mu}, {sigma}, and arbitrary percentiles. Unlike presently used methods, such as the program ASENT which is based on the Cramer-Rao theorem, it can analyze the results of all sensitivity tests, and it does not significantly underestimate the size of the confidence regions. The new test and analysis methods will be explained and compared to the presently used methods. 19 refs., 12 figs.

  11. Sensitivity analysis in computational aerodynamics

    NASA Technical Reports Server (NTRS)

    Bristow, D. R.

    1984-01-01

    Information on sensitivity analysis in computational aerodynamics is given in outline, graphical, and chart form. The prediction accuracy if the MCAERO program, a perturbation analysis method, is discussed. A procedure for calculating perturbation matrix, baseline wing paneling for perturbation analysis test cases and applications of an inviscid sensitivity matrix are among the topics covered.

  12. Recent developments in structural sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Haftka, Raphael T.; Adelman, Howard M.

    1988-01-01

    Recent developments are reviewed in two major areas of structural sensitivity analysis: sensitivity of static and transient response; and sensitivity of vibration and buckling eigenproblems. Recent developments from the standpoint of computational cost, accuracy, and ease of implementation are presented. In the area of static response, current interest is focused on sensitivity to shape variation and sensitivity of nonlinear response. Two general approaches are used for computing sensitivities: differentiation of the continuum equations followed by discretization, and the reverse approach of discretization followed by differentiation. It is shown that the choice of methods has important accuracy and implementation implications. In the area of eigenproblem sensitivity, there is a great deal of interest and significant progress in sensitivity of problems with repeated eigenvalues. In addition to reviewing recent contributions in this area, the paper raises the issue of differentiability and continuity associated with the occurrence of repeated eigenvalues.

  13. Additional EIPC Study Analysis. Final Report

    SciTech Connect

    Hadley, Stanton W; Gotham, Douglas J.; Luciani, Ralph L.

    2014-12-01

    Between 2010 and 2012 the Eastern Interconnection Planning Collaborative (EIPC) conducted a major long-term resource and transmission study of the Eastern Interconnection (EI). With guidance from a Stakeholder Steering Committee (SSC) that included representatives from the Eastern Interconnection States Planning Council (EISPC) among others, the project was conducted in two phases. Phase 1 involved a long-term capacity expansion analysis that involved creation of eight major futures plus 72 sensitivities. Three scenarios were selected for more extensive transmission- focused evaluation in Phase 2. Five power flow analyses, nine production cost model runs (including six sensitivities), and three capital cost estimations were developed during this second phase. The results from Phase 1 and 2 provided a wealth of data that could be examined further to address energy-related questions. A list of 14 topics was developed for further analysis. This paper brings together the earlier interim reports of the first 13 topics plus one additional topic into a single final report.

  14. Nitrogen Addition Enhances Drought Sensitivity of Young Deciduous Tree Species

    PubMed Central

    Dziedek, Christoph; Härdtle, Werner; von Oheimb, Goddert; Fichtner, Andreas

    2016-01-01

    Understanding how trees respond to global change drivers is central to predict changes in forest structure and functions. Although there is evidence on the mode of nitrogen (N) and drought (D) effects on tree growth, our understanding of the interplay of these factors is still limited. Simultaneously, as mixtures are expected to be less sensitive to global change as compared to monocultures, we aimed to investigate the combined effects of N addition and D on the productivity of three tree species (Fagus sylvatica, Quercus petraea, Pseudotsuga menziesii) in relation to functional diverse species mixtures using data from a 4-year field experiment in Northwest Germany. Here we show that species mixing can mitigate the negative effects of combined N fertilization and D events, but the community response is mainly driven by the combination of certain traits rather than the tree species richness of a community. For beech, we found that negative effects of D on growth rates were amplified by N fertilization (i.e., combined treatment effects were non-additive), while for oak and fir, the simultaneous effects of N and D were additive. Beech and oak were identified as most sensitive to combined N+D effects with a strong size-dependency observed for beech, suggesting that the negative impact of N+D becomes stronger with time as beech grows larger. As a consequence, the net biodiversity effect declined at the community level, which can be mainly assigned to a distinct loss of complementarity in beech-oak mixtures. This pattern, however, was not evident in the other species-mixtures, indicating that neighborhood composition (i.e., trait combination), but not tree species richness mediated the relationship between tree diversity and treatment effects on tree growth. Our findings point to the importance of the qualitative role (‘trait portfolio’) that biodiversity play in determining resistance of diverse tree communities to environmental changes. As such, they provide

  15. Nitrogen Addition Enhances Drought Sensitivity of Young Deciduous Tree Species.

    PubMed

    Dziedek, Christoph; Härdtle, Werner; von Oheimb, Goddert; Fichtner, Andreas

    2016-01-01

    Understanding how trees respond to global change drivers is central to predict changes in forest structure and functions. Although there is evidence on the mode of nitrogen (N) and drought (D) effects on tree growth, our understanding of the interplay of these factors is still limited. Simultaneously, as mixtures are expected to be less sensitive to global change as compared to monocultures, we aimed to investigate the combined effects of N addition and D on the productivity of three tree species (Fagus sylvatica, Quercus petraea, Pseudotsuga menziesii) in relation to functional diverse species mixtures using data from a 4-year field experiment in Northwest Germany. Here we show that species mixing can mitigate the negative effects of combined N fertilization and D events, but the community response is mainly driven by the combination of certain traits rather than the tree species richness of a community. For beech, we found that negative effects of D on growth rates were amplified by N fertilization (i.e., combined treatment effects were non-additive), while for oak and fir, the simultaneous effects of N and D were additive. Beech and oak were identified as most sensitive to combined N+D effects with a strong size-dependency observed for beech, suggesting that the negative impact of N+D becomes stronger with time as beech grows larger. As a consequence, the net biodiversity effect declined at the community level, which can be mainly assigned to a distinct loss of complementarity in beech-oak mixtures. This pattern, however, was not evident in the other species-mixtures, indicating that neighborhood composition (i.e., trait combination), but not tree species richness mediated the relationship between tree diversity and treatment effects on tree growth. Our findings point to the importance of the qualitative role ('trait portfolio') that biodiversity play in determining resistance of diverse tree communities to environmental changes. As such, they provide further

  16. Extended Forward Sensitivity Analysis for Uncertainty Quantification

    SciTech Connect

    Haihua Zhao; Vincent A. Mousseau

    2008-09-01

    This report presents the forward sensitivity analysis method as a means for quantification of uncertainty in system analysis. The traditional approach to uncertainty quantification is based on a “black box” approach. The simulation tool is treated as an unknown signal generator, a distribution of inputs according to assumed probability density functions is sent in and the distribution of the outputs is measured and correlated back to the original input distribution. This approach requires large number of simulation runs and therefore has high computational cost. Contrary to the “black box” method, a more efficient sensitivity approach can take advantage of intimate knowledge of the simulation code. In this approach equations for the propagation of uncertainty are constructed and the sensitivity is solved for as variables in the same simulation. This “glass box” method can generate similar sensitivity information as the above “black box” approach with couples of runs to cover a large uncertainty region. Because only small numbers of runs are required, those runs can be done with a high accuracy in space and time ensuring that the uncertainty of the physical model is being measured and not simply the numerical error caused by the coarse discretization. In the forward sensitivity method, the model is differentiated with respect to each parameter to yield an additional system of the same size as the original one, the result of which is the solution sensitivity. The sensitivity of any output variable can then be directly obtained from these sensitivities by applying the chain rule of differentiation. We extend the forward sensitivity method to include time and spatial steps as special parameters so that the numerical errors can be quantified against other physical parameters. This extension makes the forward sensitivity method a much more powerful tool to help uncertainty analysis. By knowing the relative sensitivity of time and space steps with other

  17. Multiple predictor smoothing methods for sensitivity analysis.

    SciTech Connect

    Helton, Jon Craig; Storlie, Curtis B.

    2006-08-01

    The use of multiple predictor smoothing methods in sampling-based sensitivity analyses of complex models is investigated. Specifically, sensitivity analysis procedures based on smoothing methods employing the stepwise application of the following nonparametric regression techniques are described: (1) locally weighted regression (LOESS), (2) additive models, (3) projection pursuit regression, and (4) recursive partitioning regression. The indicated procedures are illustrated with both simple test problems and results from a performance assessment for a radioactive waste disposal facility (i.e., the Waste Isolation Pilot Plant). As shown by the example illustrations, the use of smoothing procedures based on nonparametric regression techniques can yield more informative sensitivity analysis results than can be obtained with more traditional sensitivity analysis procedures based on linear regression, rank regression or quadratic regression when nonlinear relationships between model inputs and model predictions are present.

  18. SEP thrust subsystem performance sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Atkins, K. L.; Sauer, C. G., Jr.; Kerrisk, D. J.

    1973-01-01

    This is a two-part report on solar electric propulsion (SEP) performance sensitivity analysis. The first part describes the preliminary analysis of the SEP thrust system performance for an Encke rendezvous mission. A detailed description of thrust subsystem hardware tolerances on mission performance is included together with nominal spacecraft parameters based on these tolerances. The second part describes the method of analysis and graphical techniques used in generating the data for Part 1. Included is a description of both the trajectory program used and the additional software developed for this analysis. Part 2 also includes a comprehensive description of the use of the graphical techniques employed in this performance analysis.

  19. An analysis of sensitivity tests

    SciTech Connect

    Neyer, B.T.

    1992-03-06

    A new method of analyzing sensitivity tests is proposed. It uses the Likelihood Ratio Test to compute regions of arbitrary confidence. It can calculate confidence regions for the parameters of the distribution (e.g., the mean, {mu}, and the standard deviation, {sigma}) as well as various percentiles. Unlike presently used methods, such as those based on asymptotic analysis, it can analyze the results of all sensitivity tests, and it does not significantly underestimate the size of the confidence regions. The main disadvantage of this method is that it requires much more computation to calculate the confidence regions. However, these calculations can be easily and quickly performed on most computers.

  20. Comparative Sensitivity Analysis of Muscle Activation Dynamics

    PubMed Central

    Rockenfeller, Robert; Günther, Michael; Schmitt, Syn; Götz, Thomas

    2015-01-01

    We mathematically compared two models of mammalian striated muscle activation dynamics proposed by Hatze and Zajac. Both models are representative for a broad variety of biomechanical models formulated as ordinary differential equations (ODEs). These models incorporate parameters that directly represent known physiological properties. Other parameters have been introduced to reproduce empirical observations. We used sensitivity analysis to investigate the influence of model parameters on the ODE solutions. In addition, we expanded an existing approach to treating initial conditions as parameters and to calculating second-order sensitivities. Furthermore, we used a global sensitivity analysis approach to include finite ranges of parameter values. Hence, a theoretician striving for model reduction could use the method for identifying particularly low sensitivities to detect superfluous parameters. An experimenter could use it for identifying particularly high sensitivities to improve parameter estimation. Hatze's nonlinear model incorporates some parameters to which activation dynamics is clearly more sensitive than to any parameter in Zajac's linear model. Other than Zajac's model, Hatze's model can, however, reproduce measured shifts in optimal muscle length with varied muscle activity. Accordingly we extracted a specific parameter set for Hatze's model that combines best with a particular muscle force-length relation. PMID:26417379

  1. Comparative Sensitivity Analysis of Muscle Activation Dynamics.

    PubMed

    Rockenfeller, Robert; Günther, Michael; Schmitt, Syn; Götz, Thomas

    2015-01-01

    We mathematically compared two models of mammalian striated muscle activation dynamics proposed by Hatze and Zajac. Both models are representative for a broad variety of biomechanical models formulated as ordinary differential equations (ODEs). These models incorporate parameters that directly represent known physiological properties. Other parameters have been introduced to reproduce empirical observations. We used sensitivity analysis to investigate the influence of model parameters on the ODE solutions. In addition, we expanded an existing approach to treating initial conditions as parameters and to calculating second-order sensitivities. Furthermore, we used a global sensitivity analysis approach to include finite ranges of parameter values. Hence, a theoretician striving for model reduction could use the method for identifying particularly low sensitivities to detect superfluous parameters. An experimenter could use it for identifying particularly high sensitivities to improve parameter estimation. Hatze's nonlinear model incorporates some parameters to which activation dynamics is clearly more sensitive than to any parameter in Zajac's linear model. Other than Zajac's model, Hatze's model can, however, reproduce measured shifts in optimal muscle length with varied muscle activity. Accordingly we extracted a specific parameter set for Hatze's model that combines best with a particular muscle force-length relation. PMID:26417379

  2. Additional Investigations of Ice Shape Sensitivity to Parameter Variations

    NASA Technical Reports Server (NTRS)

    Miller, Dean R.; Potapczuk, Mark G.; Langhals, Tammy J.

    2006-01-01

    A second parameter sensitivity study was conducted at the NASA Glenn Research Center's Icing Research Tunnel (IRT) using a 36 in. chord (0.91 m) NACA-0012 airfoil. The objective of this work was to further investigate the feasibility of using ice shape feature changes to define requirements for the simulation and measurement of SLD and appendix C icing conditions. A previous study concluded that it was feasible to use changes in ice shape features (e.g., ice horn angle, ice horn thickness, and ice shape mass) to detect relatively small variations in icing spray condition parameters (LWC, MVD, and temperature). The subject of this current investigation extends the scope of this previous work, by also examining the effect of icing tunnel spray-bar parameter variations (water pressure, air pressure) on ice shape feature changes. The approach was to vary spray-bar water pressure and air pressure, and then evaluate the effects of these parameter changes on the resulting ice shapes. This paper will provide a description of the experimental method, present selected experimental results, and conclude with an evaluation of these results.

  3. Multitarget global sensitivity analysis of n-butanol combustion.

    PubMed

    Zhou, Dingyu D Y; Davis, Michael J; Skodje, Rex T

    2013-05-01

    A model for the combustion of butanol is studied using a recently developed theoretical method for the systematic improvement of the kinetic mechanism. The butanol mechanism includes 1446 reactions, and we demonstrate that it is straightforward and computationally feasible to implement a full global sensitivity analysis incorporating all the reactions. In addition, we extend our previous analysis of ignition-delay targets to include species targets. The combination of species and ignition targets leads to multitarget global sensitivity analysis, which allows for a more complete mechanism validation procedure than we previously implemented. The inclusion of species sensitivity analysis allows for a direct comparison between reaction pathway analysis and global sensitivity analysis. PMID:23530815

  4. Sensitivity and Uncertainty Analysis Shell

    1999-04-20

    SUNS (Sensitivity and Uncertainty Analysis Shell) is a 32-bit application that runs under Windows 95/98 and Windows NT. It is designed to aid in statistical analyses for a broad range of applications. The class of problems for which SUNS is suitable is generally defined by two requirements: 1. A computer code is developed or acquired that models some processes for which input is uncertain and the user is interested in statistical analysis of the outputmore » of that code. 2. The statistical analysis of interest can be accomplished using the Monte Carlo analysis. The implementation then requires that the user identify which input to the process model is to be manipulated for statistical analysis. With this information, the changes required to loosely couple SUNS with the process model can be completed. SUNS is then used to generate the required statistical sample and the user-supplied process model analyses the sample. The SUNS post processor displays statistical results from any existing file that contains sampled input and output values.« less

  5. Using Dynamic Sensitivity Analysis to Assess Testability

    NASA Technical Reports Server (NTRS)

    Voas, Jeffrey; Morell, Larry; Miller, Keith

    1990-01-01

    This paper discusses sensitivity analysis and its relationship to random black box testing. Sensitivity analysis estimates the impact that a programming fault at a particular location would have on the program's input/output behavior. Locations that are relatively \\"insensitive" to faults can render random black box testing unlikely to uncover programming faults. Therefore, sensitivity analysis gives new insight when interpreting random black box testing results. Although sensitivity analysis is computationally intensive, it requires no oracle and no human intervention.

  6. Stiff DAE integrator with sensitivity analysis capabilities

    2007-11-26

    IDAS is a general purpose (serial and parallel) solver for differential equation (ODE) systems with senstivity analysis capabilities. It provides both forward and adjoint sensitivity analysis options.

  7. Point Source Location Sensitivity Analysis

    NASA Astrophysics Data System (ADS)

    Cox, J. Allen

    1986-11-01

    This paper presents the results of an analysis of point source location accuracy and sensitivity as a function of focal plane geometry, optical blur spot, and location algorithm. Five specific blur spots are treated: gaussian, diffraction-limited circular aperture with and without central obscuration (obscured and clear bessinc, respectively), diffraction-limited rectangular aperture, and a pill box distribution. For each blur spot, location accuracies are calculated for square, rectangular, and hexagonal detector shapes of equal area. The rectangular detectors are arranged on a hexagonal lattice. The two location algorithms consist of standard and generalized centroid techniques. Hexagonal detector arrays are shown to give the best performance under a wide range of conditions.

  8. Scalable analysis tools for sensitivity analysis and UQ (3160) results.

    SciTech Connect

    Karelitz, David B.; Ice, Lisa G.; Thompson, David C.; Bennett, Janine C.; Fabian, Nathan; Scott, W. Alan; Moreland, Kenneth D.

    2009-09-01

    The 9/30/2009 ASC Level 2 Scalable Analysis Tools for Sensitivity Analysis and UQ (Milestone 3160) contains feature recognition capability required by the user community for certain verification and validation tasks focused around sensitivity analysis and uncertainty quantification (UQ). These feature recognition capabilities include crater detection, characterization, and analysis from CTH simulation data; the ability to call fragment and crater identification code from within a CTH simulation; and the ability to output fragments in a geometric format that includes data values over the fragments. The feature recognition capabilities were tested extensively on sample and actual simulations. In addition, a number of stretch criteria were met including the ability to visualize CTH tracer particles and the ability to visualize output from within an S3D simulation.

  9. A review of sensitivity analysis techniques

    SciTech Connect

    Hamby, D.M.

    1993-12-31

    Mathematical models are utilized to approximate various highly complex engineering, physical, environmental, social, and economic phenomena. Model parameters exerting the most influence on model results are identified through a {open_quotes}sensitivity analysis.{close_quotes} A comprehensive review is presented of more than a dozen sensitivity analysis methods. The most fundamental of sensitivity techniques utilizes partial differentiation whereas the simplest approach requires varying parameter values one-at-a-time. Correlation analysis is used to determine relationships between independent and dependent variables. Regression analysis provides the most comprehensive sensitivity measure and is commonly utilized to build response surfaces that approximate complex models.

  10. Design sensitivity analysis of nonlinear structural response

    NASA Technical Reports Server (NTRS)

    Cardoso, J. B.; Arora, J. S.

    1987-01-01

    A unified theory is described of design sensitivity analysis of linear and nonlinear structures for shape, nonshape and material selection problems. The concepts of reference volume and adjoint structure are used to develop the unified viewpoint. A general formula for design sensitivity analysis is derived. Simple analytical linear and nonlinear examples are used to interpret various terms of the formula and demonstrate its use.

  11. Sensitivity analysis of a wing aeroelastic response

    NASA Technical Reports Server (NTRS)

    Kapania, Rakesh K.; Eldred, Lloyd B.; Barthelemy, Jean-Francois M.

    1991-01-01

    A variation of Sobieski's Global Sensitivity Equations (GSE) approach is implemented to obtain the sensitivity of the static aeroelastic response of a three-dimensional wing model. The formulation is quite general and accepts any aerodynamics and structural analysis capability. An interface code is written to convert one analysis's output to the other's input, and visa versa. Local sensitivity derivatives are calculated by either analytic methods or finite difference techniques. A program to combine the local sensitivities, such as the sensitivity of the stiffness matrix or the aerodynamic kernel matrix, into global sensitivity derivatives is developed. The aerodynamic analysis package FAST, using a lifting surface theory, and a structural package, ELAPS, implementing Giles' equivalent plate model are used.

  12. Sensitivity Analysis for some Water Pollution Problem

    NASA Astrophysics Data System (ADS)

    Le Dimet, François-Xavier; Tran Thu, Ha; Hussaini, Yousuff

    2014-05-01

    Sensitivity Analysis for Some Water Pollution Problems Francois-Xavier Le Dimet1 & Tran Thu Ha2 & M. Yousuff Hussaini3 1Université de Grenoble, France, 2Vietnamese Academy of Sciences, 3 Florida State University Sensitivity analysis employs some response function and the variable with respect to which its sensitivity is evaluated. If the state of the system is retrieved through a variational data assimilation process, then the observation appears only in the Optimality System (OS). In many cases, observations have errors and it is important to estimate their impact. Therefore, sensitivity analysis has to be carried out on the OS, and in that sense sensitivity analysis is a second order property. The OS can be considered as a generalized model because it contains all the available information. This presentation proposes a method to carry out sensitivity analysis in general. The method is demonstrated with an application to water pollution problem. The model involves shallow waters equations and an equation for the pollutant concentration. These equations are discretized using a finite volume method. The response function depends on the pollutant source, and its sensitivity with respect to the source term of the pollutant is studied. Specifically, we consider: • Identification of unknown parameters, and • Identification of sources of pollution and sensitivity with respect to the sources. We also use a Singular Evolutive Interpolated Kalman Filter to study this problem. The presentation includes a comparison of the results from these two methods. .

  13. LOX/GOX sensitivity of fluoroelastomers. [effect of formulation components and addition of fire retardants

    NASA Technical Reports Server (NTRS)

    Kirshen, N.; Mill, T.

    1973-01-01

    The effect of formulation components and the addition of fire retardants on the impact sensitivity of Viton B fluoroelastomer in liquid oxygen was studied with the objective of developing a procedure for reliably reducing this sensitivity. Component evaluation, carried out on more than 40 combinations of components and cure cycles, showed that almost all the standard formulation agents, including carbon, MgO, Diak-3, and PbO2, will sensitize the Viton stock either singly or in combinations, some combinations being much more sensitive than others. Cure and postcure treatments usually reduced the sensitivity of a given formulation, often dramatically, but no formulated Viton was as insensitive as the pure Viton B stock. Coating formulated Viton with a thin layer of pure Viton gave some indication of reduced sensitivity, but additional tests are needed. It is concluded that sensitivity in formulated Viton arises from a variety of sources, some physical and some chemical in origin. Elemental analyses for all the formulated Vitons are reported as are the results of a literature search on the subject of LOX impact sensitivity.

  14. Extended Forward Sensitivity Analysis for Uncertainty Quantification

    SciTech Connect

    Haihua Zhao; Vincent A. Mousseau

    2013-01-01

    This paper presents the extended forward sensitivity analysis as a method to help uncertainty qualification. By including time step and potentially spatial step as special sensitivity parameters, the forward sensitivity method is extended as one method to quantify numerical errors. Note that by integrating local truncation errors over the whole system through the forward sensitivity analysis process, the generated time step and spatial step sensitivity information reflect global numerical errors. The discretization errors can be systematically compared against uncertainties due to other physical parameters. This extension makes the forward sensitivity method a much more powerful tool to help uncertainty qualification. By knowing the relative sensitivity of time and space steps with other interested physical parameters, the simulation is allowed to run at optimized time and space steps without affecting the confidence of the physical parameter sensitivity results. The time and space steps forward sensitivity analysis method can also replace the traditional time step and grid convergence study with much less computational cost. Two well-defined benchmark problems with manufactured solutions are utilized to demonstrate the method.

  15. Updated Chemical Kinetics and Sensitivity Analysis Code

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, Krishnan

    2005-01-01

    An updated version of the General Chemical Kinetics and Sensitivity Analysis (LSENS) computer code has become available. A prior version of LSENS was described in "Program Helps to Determine Chemical-Reaction Mechanisms" (LEW-15758), NASA Tech Briefs, Vol. 19, No. 5 (May 1995), page 66. To recapitulate: LSENS solves complex, homogeneous, gas-phase, chemical-kinetics problems (e.g., combustion of fuels) that are represented by sets of many coupled, nonlinear, first-order ordinary differential equations. LSENS has been designed for flexibility, convenience, and computational efficiency. The present version of LSENS incorporates mathematical models for (1) a static system; (2) steady, one-dimensional inviscid flow; (3) reaction behind an incident shock wave, including boundary layer correction; (4) a perfectly stirred reactor; and (5) a perfectly stirred reactor followed by a plug-flow reactor. In addition, LSENS can compute equilibrium properties for the following assigned states: enthalpy and pressure, temperature and pressure, internal energy and volume, and temperature and volume. For static and one-dimensional-flow problems, including those behind an incident shock wave and following a perfectly stirred reactor calculation, LSENS can compute sensitivity coefficients of dependent variables and their derivatives, with respect to the initial values of dependent variables and/or the rate-coefficient parameters of the chemical reactions.

  16. Extended Forward Sensitivity Analysis for Uncertainty Quantification

    SciTech Connect

    Haihua Zhao; Vincent A. Mousseau

    2011-09-01

    Verification and validation (V&V) are playing more important roles to quantify uncertainties and realize high fidelity simulations in engineering system analyses, such as transients happened in a complex nuclear reactor system. Traditional V&V in the reactor system analysis focused more on the validation part or did not differentiate verification and validation. The traditional approach to uncertainty quantification is based on a 'black box' approach. The simulation tool is treated as an unknown signal generator, a distribution of inputs according to assumed probability density functions is sent in and the distribution of the outputs is measured and correlated back to the original input distribution. The 'black box' method mixes numerical errors with all other uncertainties. It is also not efficient to perform sensitivity analysis. Contrary to the 'black box' method, a more efficient sensitivity approach can take advantage of intimate knowledge of the simulation code. In these types of approaches equations for the propagation of uncertainty are constructed and the sensitivities are directly solved for as variables in the simulation. This paper presents the forward sensitivity analysis as a method to help uncertainty qualification. By including time step and potentially spatial step as special sensitivity parameters, the forward sensitivity method is extended as one method to quantify numerical errors. Note that by integrating local truncation errors over the whole system through the forward sensitivity analysis process, the generated time step and spatial step sensitivity information reflect global numerical errors. The discretization errors can be systematically compared against uncertainties due to other physical parameters. This extension makes the forward sensitivity method a much more powerful tool to help uncertainty qualification. By knowing the relative sensitivity of time and space steps with other interested physical parameters, the simulation is allowed

  17. Acid Rain Analysis by Standard Addition Titration.

    ERIC Educational Resources Information Center

    Ophardt, Charles E.

    1985-01-01

    The standard addition titration is a precise and rapid method for the determination of the acidity in rain or snow samples. The method requires use of a standard buret, a pH meter, and Gran's plot to determine the equivalence point. Experimental procedures used and typical results obtained are presented. (JN)

  18. Coal Transportation Rate Sensitivity Analysis

    EIA Publications

    2005-01-01

    On December 21, 2004, the Surface Transportation Board (STB) requested that the Energy Information Administration (EIA) analyze the impact of changes in coal transportation rates on projected levels of electric power sector energy use and emissions. Specifically, the STB requested an analysis of changes in national and regional coal consumption and emissions resulting from adjustments in railroad transportation rates for Wyoming's Powder River Basin (PRB) coal using the National Energy Modeling System (NEMS). However, because NEMS operates at a relatively aggregate regional level and does not represent the costs of transporting coal over specific rail lines, this analysis reports on the impacts of interregional changes in transportation rates from those used in the Annual Energy Outlook 2005 (AEO2005) reference case.

  19. Sensitivity analysis for solar plates

    NASA Technical Reports Server (NTRS)

    Aster, R. W.

    1986-01-01

    Economic evaluation methods and analyses of emerging photovoltaic (PV) technology since 1976 was prepared. This type of analysis was applied to the silicon research portion of the PV Program in order to determine the importance of this research effort in relationship to the successful development of commercial PV systems. All four generic types of PV that use silicon were addressed: crystal ingots grown either by the Czochralski method or an ingot casting method; ribbons pulled directly from molten silicon; an amorphous silicon thin film; and use of high concentration lenses. Three technologies were analyzed: the Union Carbide fluidized bed reactor process, the Hemlock process, and the Union Carbide Komatsu process. The major components of each process were assessed in terms of the costs of capital equipment, labor, materials, and utilities. These assessments were encoded as the probabilities assigned by experts for achieving various cost values or production rates.

  20. Sensitivity analysis for solar plates

    NASA Astrophysics Data System (ADS)

    Aster, R. W.

    1986-02-01

    Economic evaluation methods and analyses of emerging photovoltaic (PV) technology since 1976 was prepared. This type of analysis was applied to the silicon research portion of the PV Program in order to determine the importance of this research effort in relationship to the successful development of commercial PV systems. All four generic types of PV that use silicon were addressed: crystal ingots grown either by the Czochralski method or an ingot casting method; ribbons pulled directly from molten silicon; an amorphous silicon thin film; and use of high concentration lenses. Three technologies were analyzed: the Union Carbide fluidized bed reactor process, the Hemlock process, and the Union Carbide Komatsu process. The major components of each process were assessed in terms of the costs of capital equipment, labor, materials, and utilities. These assessments were encoded as the probabilities assigned by experts for achieving various cost values or production rates.

  1. Additives

    NASA Technical Reports Server (NTRS)

    Smalheer, C. V.

    1973-01-01

    The chemistry of lubricant additives is discussed to show what the additives are chemically and what functions they perform in the lubrication of various kinds of equipment. Current theories regarding the mode of action of lubricant additives are presented. The additive groups discussed include the following: (1) detergents and dispersants, (2) corrosion inhibitors, (3) antioxidants, (4) viscosity index improvers, (5) pour point depressants, and (6) antifouling agents.

  2. Effect of basic additives on sensitivity and diffusion of acid in chemical amplification resists

    NASA Astrophysics Data System (ADS)

    Asakawa, Koji; Ushirogouchi, Tohru; Nakase, Makoto

    1995-06-01

    The effect of amine additives in chemical amplification resists is discussed. Phenolic amines such as 4-aminophenol and 2-(4-aminophenyl)-2-(4-hydroxyphenyl) propane were investigated as model compounds from the viewpoint of sensitivity, diffusion and resolution. Equal molar amounts of acid and amine deactivated at the very beginning of post-exposure bake, and could not participate in decomposing the inhibitor as a catalyst. Only the acid which survived from the deactivation diffuses in the resist, decomposing the inhibitors from the middle to late stage of PEB. The basic additives reduce the diffusion range of the acid, especially for long-range diffusion, resulting in higher contrast at the interfaces between the exposed and unexposed areas. In addition, the amine concentration required is found to be less than the concentration which causes the resist sensitivity to start decreasing.

  3. Adjoint sensitivity analysis of an ultrawideband antenna

    SciTech Connect

    Stephanson, M B; White, D A

    2011-07-28

    The frequency domain finite element method using H(curl)-conforming finite elements is a robust technique for full-wave analysis of antennas. As computers become more powerful, it is becoming feasible to not only predict antenna performance, but also to compute sensitivity of antenna performance with respect to multiple parameters. This sensitivity information can then be used for optimization of the design or specification of manufacturing tolerances. In this paper we review the Adjoint Method for sensitivity calculation, and apply it to the problem of optimizing a Ultrawideband antenna.

  4. Sensitivity Tuning through Additive Heterogeneous Plasmon Coupling between 3D Assembled Plasmonic Nanoparticle and Nanocup Arrays.

    PubMed

    Seo, Sujin; Zhou, Xiangfei; Liu, Gang Logan

    2016-07-01

    Plasmonic substrates have fixed sensitivity once the geometry of the structure is defined. In order to improve the sensitivity, significant research effort has been focused on designing new plasmonic structures, which involves high fabrication costs; however, a method is reported for improving sensitivity not by redesigning the structure but by simply assembling plasmonic nanoparticles (NPs) near the evanescent field of the underlying 3D plasmonic nanostructure. Here, a nanoscale Lycurgus cup array (nanoLCA) is employed as a base colorimetric plasmonic substrate and an assembly template. Compared to the nanoLCA, the NP assembled nanoLCA (NP-nanoLCA) exhibits much higher sensitivity for both bulk refractive index sensing and biotin-streptavidin binding detection. The limit of detection of the NP-nanoLCA is at least ten times smaller when detecting biotin-streptavidin conjugation. The numerical calculations confirm the importance of the additive plasmon coupling between the NPs and the nanoLCA for a denser and stronger electric field in the same 3D volumetric space. Tunable sensitivity is accomplished by controlling the number of NPs in each nanocup, or the number density of the hot spots. This simple yet scalable and cost-effective method of using additive heterogeneous plasmon coupling effects will benefit various chemical, medical, and environmental plasmon-based sensors. PMID:27206214

  5. Sensitivity Analysis in the Model Web

    NASA Astrophysics Data System (ADS)

    Jones, R.; Cornford, D.; Boukouvalas, A.

    2012-04-01

    The Model Web, and in particular the Uncertainty enabled Model Web being developed in the UncertWeb project aims to allow model developers and model users to deploy and discover models exposed as services on the Web. In particular model users will be able to compose model and data resources to construct and evaluate complex workflows. When discovering such workflows and models on the Web it is likely that the users might not have prior experience of the model behaviour in detail. It would be particularly beneficial if users could undertake a sensitivity analysis of the models and workflows they have discovered and constructed to allow them to assess the sensitivity to their assumptions and parameters. This work presents a Web-based sensitivity analysis tool which provides computationally efficient sensitivity analysis methods for models exposed on the Web. In particular the tool is tailored to the UncertWeb profiles for both information models (NetCDF and Observations and Measurements) and service specifications (WPS and SOAP/WSDL). The tool employs emulation technology where this is found to be possible, constructing statistical surrogate models for the models or workflows, to allow very fast variance based sensitivity analysis. Where models are too complex for emulation to be possible, or evaluate too fast for this to be necessary the original models are used with a carefully designed sampling strategy. A particular benefit of constructing emulators of the models or workflow components is that within the framework these can be communicated and evaluated at any physical location. The Web-based tool and backend API provide several functions to facilitate the process of creating an emulator and performing sensitivity analysis. A user can select a model exposed on the Web and specify the input ranges. Once this process is complete, they are able to perform screening to discover important inputs, train an emulator, and validate the accuracy of the trained emulator. In

  6. Sensitivity analysis and application in exploration geophysics

    NASA Astrophysics Data System (ADS)

    Tang, R.

    2013-12-01

    In exploration geophysics, the usual way of dealing with geophysical data is to form an Earth model describing underground structure in the area of investigation. The resolved model, however, is based on the inversion of survey data which is unavoidable contaminated by various noises and is sampled in a limited number of observation sites. Furthermore, due to the inherent non-unique weakness of inverse geophysical problem, the result is ambiguous. And it is not clear that which part of model features is well-resolved by the data. Therefore the interpretation of the result is intractable. We applied a sensitivity analysis to address this problem in magnetotelluric(MT). The sensitivity, also named Jacobian matrix or the sensitivity matrix, is comprised of the partial derivatives of the data with respect to the model parameters. In practical inversion, the matrix can be calculated by direct modeling of the theoretical response for the given model perturbation, or by the application of perturbation approach and reciprocity theory. We now acquired visualized sensitivity plot by calculating the sensitivity matrix and the solution is therefore under investigation that the less-resolved part is indicated and should not be considered in interpretation, while the well-resolved parameters can relatively be convincing. The sensitivity analysis is hereby a necessary and helpful tool for increasing the reliability of inverse models. Another main problem of exploration geophysics is about the design strategies of joint geophysical survey, i.e. gravity, magnetic & electromagnetic method. Since geophysical methods are based on the linear or nonlinear relationship between observed data and subsurface parameters, an appropriate design scheme which provides maximum information content within a restricted budget is quite difficult. Here we firstly studied sensitivity of different geophysical methods by mapping the spatial distribution of different survey sensitivity with respect to the

  7. Probabilistic sensitivity analysis in health economics.

    PubMed

    Baio, Gianluca; Dawid, A Philip

    2015-12-01

    Health economic evaluations have recently become an important part of the clinical and medical research process and have built upon more advanced statistical decision-theoretic foundations. In some contexts, it is officially required that uncertainty about both parameters and observable variables be properly taken into account, increasingly often by means of Bayesian methods. Among these, probabilistic sensitivity analysis has assumed a predominant role. The objective of this article is to review the problem of health economic assessment from the standpoint of Bayesian statistical decision theory with particular attention to the philosophy underlying the procedures for sensitivity analysis. PMID:21930515

  8. A numerical comparison of sensitivity analysis techniques

    SciTech Connect

    Hamby, D.M.

    1993-12-31

    Engineering and scientific phenomena are often studied with the aid of mathematical models designed to simulate complex physical processes. In the nuclear industry, modeling the movement and consequence of radioactive pollutants is extremely important for environmental protection and facility control. One of the steps in model development is the determination of the parameters most influential on model results. A {open_quotes}sensitivity analysis{close_quotes} of these parameters is not only critical to model validation but also serves to guide future research. A previous manuscript (Hamby) detailed many of the available methods for conducting sensitivity analyses. The current paper is a comparative assessment of several methods for estimating relative parameter sensitivity. Method practicality is based on calculational ease and usefulness of the results. It is the intent of this report to demonstrate calculational rigor and to compare parameter sensitivity rankings resulting from various sensitivity analysis techniques. An atmospheric tritium dosimetry model (Hamby) is used here as an example, but the techniques described can be applied to many different modeling problems. Other investigators (Rose; Dalrymple and Broyd) present comparisons of sensitivity analyses methodologies, but none as comprehensive as the current work.

  9. Pediatric Pain, Predictive Inference, and Sensitivity Analysis.

    ERIC Educational Resources Information Center

    Weiss, Robert

    1994-01-01

    Coping style and effects of counseling intervention on pain tolerance was studied for 61 elementary school students through immersion of hands in cold water. Bayesian predictive inference tools are able to distinguish between subject characteristics and manipulable treatments. Sensitivity analysis strengthens the certainty of conclusions about…

  10. Influence of electrolyte co-additives on the performance of dye-sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Stergiopoulos, Thomas; Rozi, Evangelia; Karagianni, Chaido-Stefania; Falaras, Polycarpos

    2011-12-01

    The presence of specific chemical additives in the redox electrolyte results in an efficient increase of the photovoltaic performance of dye-sensitized solar cells (DSCs). The most effective additives are 4- tert-butylpyridine (TBP), N-methylbenzimidazole (NMBI) and guanidinium thiocyanate (GuNCS) that are adsorbed onto the photoelectrode/electrolyte interface, thus shifting the semiconductor's conduction band edge and preventing recombination with triiodides. In a comparative work, we investigated in detail the action of TBP and NMBI additives in ionic liquid-based redox electrolytes with varying iodine concentrations, in order to extract the optimum additive/I2 ratio for each system. Different optimum additive/I2 ratios were determined for TBP and NMBI, despite the fact that both generally work in a similar way. Further addition of GuNCS in the optimized electrolytic media causes significant synergistic effects, the action of GuNCS being strongly influenced by the nature of the corresponding co-additive. Under the best operation conditions, power conversion efficiencies as high as 8% were obtained.

  11. NIR sensitivity analysis with the VANE

    NASA Astrophysics Data System (ADS)

    Carrillo, Justin T.; Goodin, Christopher T.; Baylot, Alex E.

    2016-05-01

    Near infrared (NIR) cameras, with peak sensitivity around 905-nm wavelengths, are increasingly used in object detection applications such as pedestrian detection, occupant detection in vehicles, and vehicle detection. In this work, we present the results of simulated sensitivity analysis for object detection with NIR cameras. The analysis was conducted using high performance computing (HPC) to determine the environmental effects on object detection in different terrains and environmental conditions. The Virtual Autonomous Navigation Environment (VANE) was used to simulate highresolution models for environment, terrain, vehicles, and sensors. In the experiment, an active fiducial marker was attached to the rear bumper of a vehicle. The camera was mounted on a following vehicle that trailed at varying standoff distances. Three different terrain conditions (rural, urban, and forest), two environmental conditions (clear and hazy), three different times of day (morning, noon, and evening), and six different standoff distances were used to perform the sensor sensitivity analysis. The NIR camera that was used for the simulation is the DMK firewire monochrome on a pan-tilt motor. Standoff distance was varied along with environment and environmental conditions to determine the critical failure points for the sensor. Feature matching was used to detect the markers in each frame of the simulation, and the percentage of frames in which one of the markers was detected was recorded. The standoff distance produced the biggest impact on the performance of the camera system, while the camera system was not sensitive to environment conditions.

  12. Geothermal well cost sensitivity analysis: current status

    SciTech Connect

    Carson, C.C.; Lin, Y.T.

    1980-01-01

    The geothermal well-cost model developed by Sandia National Laboratories is being used to analyze the sensitivity of well costs to improvements in geothermal drilling technology. Three interim results from this modeling effort are discussed. The sensitivity of well costs to bit parameters, rig parameters, and material costs; an analysis of the cost reduction potential of an advanced bit; and a consideration of breakeven costs for new cementing technology. All three results illustrate that the well-cost savings arising from any new technology will be highly site-dependent but that in specific wells the advances considered can result in significant cost reductions.

  13. Sensitivity analysis for magnetic induction tomography.

    PubMed

    Soleimani, Manuchehr; Jersey-Willuhn, Karen

    2004-01-01

    This work focuses on sensitivity analysis of magnetic induction tomography in terms of theoretical modelling and numerical implementation. We will explain a new and efficient method to determine the Jacobian matrix, directly from the results of the forward solution. The results presented are for the eddy current approximation, and are given in terms of magnetic vector potential, which is computationally convenient, and which may be extracted directly from the FE solution of the forward problem. Examples of sensitivity maps for an opposite sensor geometry are also shown. PMID:17271947

  14. Nursing-sensitive indicators: a concept analysis

    PubMed Central

    Heslop, Liza; Lu, Sai

    2014-01-01

    Aim To report a concept analysis of nursing-sensitive indicators within the applied context of the acute care setting. Background The concept of ‘nursing sensitive indicators’ is valuable to elaborate nursing care performance. The conceptual foundation, theoretical role, meaning, use and interpretation of the concept tend to differ. The elusiveness of the concept and the ambiguity of its attributes may have hindered research efforts to advance its application in practice. Design Concept analysis. Data sources Using ‘clinical indicators’ or ‘quality of nursing care’ as subject headings and incorporating keyword combinations of ‘acute care’ and ‘nurs*’, CINAHL and MEDLINE with full text in EBSCOhost databases were searched for English language journal articles published between 2000–2012. Only primary research articles were selected. Methods A hybrid approach was undertaken, incorporating traditional strategies as per Walker and Avant and a conceptual matrix based on Holzemer's Outcomes Model for Health Care Research. Results The analysis revealed two main attributes of nursing-sensitive indicators. Structural attributes related to health service operation included: hours of nursing care per patient day, nurse staffing. Outcome attributes related to patient care included: the prevalence of pressure ulcer, falls and falls with injury, nosocomial selective infection and patient/family satisfaction with nursing care. Conclusion This concept analysis may be used as a basis to advance understandings of the theoretical structures that underpin both research and practical application of quality dimensions of nursing care performance. PMID:25113388

  15. Rotary absorption heat pump sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Bamberger, J. A.; Zalondek, F. R.

    1990-03-01

    Conserve Resources, Incorporated is currently developing an innovative, patented absorption heat pump. The heat pump uses rotation and thin film technology to enhance the absorption process and to provide a more efficient, compact system. The results are presented of a sensitivity analysis of the rotary absorption heat pump (RAHP) performance conducted to further the development of a 1-ton RAHP. The objective of the uncertainty analysis was to determine the sensitivity of RAHP steady state performance to uncertainties in design parameters. Prior to conducting the uncertainty analysis, a computer model was developed to describe the performance of the RAHP thermodynamic cycle. The RAHP performance is based on many interrelating factors, not all of which could be investigated during the sensitivity analysis. Confirmatory measurements of LiBr/H2O properties during absorber/generator operation will provide experimental verification that the system is operating as it was designed to operate. Quantities to be measured include: flow rate in the absorber and generator, film thickness, recirculation rate, and the effects of rotational speed on these parameters.

  16. The Volatility of Data Space: Topology Oriented Sensitivity Analysis

    PubMed Central

    Du, Jing; Ligmann-Zielinska, Arika

    2015-01-01

    Despite the difference among specific methods, existing Sensitivity Analysis (SA) technologies are all value-based, that is, the uncertainties in the model input and output are quantified as changes of values. This paradigm provides only limited insight into the nature of models and the modeled systems. In addition to the value of data, a potentially richer information about the model lies in the topological difference between pre-model data space and post-model data space. This paper introduces an innovative SA method called Topology Oriented Sensitivity Analysis, which defines sensitivity as the volatility of data space. It extends SA into a deeper level that lies in the topology of data. PMID:26368929

  17. Multicriteria Evaluation and Sensitivity Analysis on Information Security

    NASA Astrophysics Data System (ADS)

    Syamsuddin, Irfan

    2013-05-01

    Information security plays a significant role in recent information society. Increasing number and impact of cyber attacks on information assets have resulted the increasing awareness among managers that attack on information is actually attack on organization itself. Unfortunately, particular model for information security evaluation for management levels is still not well defined. In this study, decision analysis based on Ternary Analytic Hierarchy Process (T-AHP) is proposed as a novel model to aid managers who responsible in making strategic evaluation related to information security issues. In addition, sensitivity analysis is applied to extend our analysis by using several "what-if" scenarios in order to measure the consistency of the final evaluation. Finally, we conclude that the final evaluation made by managers has a significant consistency shown by sensitivity analysis results.

  18. Additives and salts for dye-sensitized solar cells electrolytes: what is the best choice?

    NASA Astrophysics Data System (ADS)

    Bella, Federico; Sacco, Adriano; Pugliese, Diego; Laurenti, Marco; Bianco, Stefano

    2014-10-01

    A multivariate chemometric approach is proposed for the first time for performance optimization of I-/I3- liquid electrolytes for dye-sensitized solar cells (DSSCs). Over the years the system composed by iodide/triiodide redox shuttle dissolved in organic solvent has been enriched with the addition of different specific cations and chemical compounds to improve the photoelectrochemical behavior of the cell. However, usually such additives act favorably with respect to some of the cell parameters and negatively to others. Moreover, the combined action of different compounds often yields contradictory results, and from the literature it is not possible to identify an optimal recipe. We report here a systematic work, based on a multivariate experimental design, to statistically and quantitatively evaluate the effect of different additives on the photovoltaic performances of the device. The effect of cation size in iodine salts, the iodine/iodide ratio in the electrolyte and the effect of type and concentration of additives are mutually evaluated by means of a Design of Experiment (DoE) approach. Through this statistical method, the optimization of the overall parameters is demonstrated with a limited number of experimental trials. A 25% improvement on the photovoltaic conversion efficiency compared with that obtained with a commercial electrolyte is demonstrated.

  19. Efficient sensitivity analysis method for chaotic dynamical systems

    NASA Astrophysics Data System (ADS)

    Liao, Haitao

    2016-05-01

    The direct differentiation and improved least squares shadowing methods are both developed for accurately and efficiently calculating the sensitivity coefficients of time averaged quantities for chaotic dynamical systems. The key idea is to recast the time averaged integration term in the form of differential equation before applying the sensitivity analysis method. An additional constraint-based equation which forms the augmented equations of motion is proposed to calculate the time averaged integration variable and the sensitivity coefficients are obtained as a result of solving the augmented differential equations. The application of the least squares shadowing formulation to the augmented equations results in an explicit expression for the sensitivity coefficient which is dependent on the final state of the Lagrange multipliers. The LU factorization technique to calculate the Lagrange multipliers leads to a better performance for the convergence problem and the computational expense. Numerical experiments on a set of problems selected from the literature are presented to illustrate the developed methods. The numerical results demonstrate the correctness and effectiveness of the present approaches and some short impulsive sensitivity coefficients are observed by using the direct differentiation sensitivity analysis method.

  20. Bayesian sensitivity analysis of a nonlinear finite element model

    NASA Astrophysics Data System (ADS)

    Becker, W.; Oakley, J. E.; Surace, C.; Gili, P.; Rowson, J.; Worden, K.

    2012-10-01

    A major problem in uncertainty and sensitivity analysis is that the computational cost of propagating probabilistic uncertainty through large nonlinear models can be prohibitive when using conventional methods (such as Monte Carlo methods). A powerful solution to this problem is to use an emulator, which is a mathematical representation of the model built from a small set of model runs at specified points in input space. Such emulators are massively cheaper to run and can be used to mimic the "true" model, with the result that uncertainty analysis and sensitivity analysis can be performed for a greatly reduced computational cost. The work here investigates the use of an emulator known as a Gaussian process (GP), which is an advanced probabilistic form of regression. The GP is particularly suited to uncertainty analysis since it is able to emulate a wide class of models, and accounts for its own emulation uncertainty. Additionally, uncertainty and sensitivity measures can be estimated analytically, given certain assumptions. The GP approach is explained in detail here, and a case study of a finite element model of an airship is used to demonstrate the method. It is concluded that the GP is a very attractive way of performing uncertainty and sensitivity analysis on large models, provided that the dimensionality is not too high.

  1. Diagnostic Analysis of Middle Atmosphere Climate Sensitivity

    NASA Astrophysics Data System (ADS)

    Zhu, X.; Cai, M.; Swartz, W. H.; Coy, L.; Yee, J.; Talaat, E. R.

    2013-12-01

    Both the middle atmosphere climate sensitivity associated with the cooling trend and its uncertainty due to a complex system of drivers increase with altitude. Furthermore, the combined effect of middle atmosphere cooling due to long-lived greenhouse gases and ozone is also associated with natural climate variations due to solar activity. To understand and predict climate change from a global perspective, we use the recently developed climate feedback-response analysis method (CFRAM) to identify and isolate the signals from the external forcing and from different feedback processes in the middle atmosphere climate system. By use of the JHU/APL middle atmosphere radiation algorithm, the CFRAM is applied to the model output fields of the high-altitude GEOS-5 climate model in the middle atmosphere to delineate the individual contributions of radiative forcing to middle atmosphere climate sensitivity.

  2. The Theoretical Foundation of Sensitivity Analysis for GPS

    NASA Astrophysics Data System (ADS)

    Shikoska, U.; Davchev, D.; Shikoski, J.

    2008-10-01

    In this paper the equations of sensitivity analysis are derived and established theoretical underpinnings for the analyses. Paper propounds a land-vehicle navigation concepts and definition for sensitivity analysis. Equations of sensitivity analysis are presented for a linear Kalman filter and case study is given to illustrate the use of sensitivity analysis to the reader. At the end of the paper, extensions that are required for this research are made to the basic equations of sensitivity analysis specifically; the equations of sensitivity analysis are re-derived for a linearized Kalman filter.

  3. LCA data quality: sensitivity and uncertainty analysis.

    PubMed

    Guo, M; Murphy, R J

    2012-10-01

    Life cycle assessment (LCA) data quality issues were investigated by using case studies on products from starch-polyvinyl alcohol based biopolymers and petrochemical alternatives. The time horizon chosen for the characterization models was shown to be an important sensitive parameter for the environmental profiles of all the polymers. In the global warming potential and the toxicity potential categories the comparison between biopolymers and petrochemical counterparts altered as the time horizon extended from 20 years to infinite time. These case studies demonstrated that the use of a single time horizon provide only one perspective on the LCA outcomes which could introduce an inadvertent bias into LCA outcomes especially in toxicity impact categories and thus dynamic LCA characterization models with varying time horizons are recommended as a measure of the robustness for LCAs especially comparative assessments. This study also presents an approach to integrate statistical methods into LCA models for analyzing uncertainty in industrial and computer-simulated datasets. We calibrated probabilities for the LCA outcomes for biopolymer products arising from uncertainty in the inventory and from data variation characteristics this has enabled assigning confidence to the LCIA outcomes in specific impact categories for the biopolymer vs. petrochemical polymer comparisons undertaken. Uncertainty combined with the sensitivity analysis carried out in this study has led to a transparent increase in confidence in the LCA findings. We conclude that LCAs lacking explicit interpretation of the degree of uncertainty and sensitivities are of limited value as robust evidence for decision making or comparative assertions. PMID:22854094

  4. Parameter sensitivity analysis of IL-6 signalling pathways.

    PubMed

    Chu, Y; Jayaraman, A; Hahn, J

    2007-11-01

    Signal transduction pathways generally consist of a large number of individual components and have an even greater number of parameters describing their reaction kinetics. Although the structure of some signalling pathways can be found in the literature, many of the parameters are not well known and they would need to be re-estimated from experimental data for each specific case. However it is not feasible to estimate hundreds of parameters because of the cost of the experiments associated with generating data. Parameter sensitivity analysis can address this situation as it investigates how the system behaviour is changed by variations of parameters and the analysis identifies which parameters play a key role in signal transduction. Only these important parameters need then be re-estimated using data from further experiments. This article presents a detailed parameter sensitivity analysis of the JAK/STAT and MAPK signal transduction pathway that is used for signalling by the cytokine IL-6. As no parameter sensitivity analysis technique is known to work best for all situations, a comparison of the results returned by four techniques is presented: differential analysis, the Morris method, a sampling-based approach and the Fourier amplitude sensitivity test. The recruitment of the transcription factor STAT3 to the dimer of the phosphorylated receptor complex is determined as the most important step by the sensitivity analysis. Additionally, the desphosphorylation of the nuclear STAT3 dimer by PP2 as well as feedback inhibition by SOCS3 are found to play an important role for signal transduction. PMID:18203580

  5. Simple Sensitivity Analysis for Orion GNC

    NASA Technical Reports Server (NTRS)

    Pressburger, Tom; Hoelscher, Brian; Martin, Rodney; Sricharan, Kumar

    2013-01-01

    The performance of Orion flight software, especially its GNC software, is being analyzed by running Monte Carlo simulations of Orion spacecraft flights. The simulated performance is analyzed for conformance with flight requirements, expressed as performance constraints. Flight requirements include guidance (e.g. touchdown distance from target) and control (e.g., control saturation) as well as performance (e.g., heat load constraints). The Monte Carlo simulations disperse hundreds of simulation input variables, for everything from mass properties to date of launch.We describe in this paper a sensitivity analysis tool (Critical Factors Tool or CFT) developed to find the input variables or pairs of variables which by themselves significantly influence satisfaction of requirements or significantly affect key performance metrics (e.g., touchdown distance from target). Knowing these factors can inform robustness analysis, can inform where engineering resources are most needed, and could even affect operations. The contributions of this paper include the introduction of novel sensitivity measures, such as estimating success probability, and a technique for determining whether pairs of factors are interacting dependently or independently. The tool found that input variables such as moments, mass, thrust dispersions, and date of launch were found to be significant factors for success of various requirements. Examples are shown in this paper as well as a summary and physics discussion of EFT-1 driving factors that the tool found.

  6. Bayesian sensitivity analysis of bifurcating nonlinear models

    NASA Astrophysics Data System (ADS)

    Becker, W.; Worden, K.; Rowson, J.

    2013-01-01

    Sensitivity analysis allows one to investigate how changes in input parameters to a system affect the output. When computational expense is a concern, metamodels such as Gaussian processes can offer considerable computational savings over Monte Carlo methods, albeit at the expense of introducing a data modelling problem. In particular, Gaussian processes assume a smooth, non-bifurcating response surface. This work highlights a recent extension to Gaussian processes which uses a decision tree to partition the input space into homogeneous regions, and then fits separate Gaussian processes to each region. In this way, bifurcations can be modelled at region boundaries and different regions can have different covariance properties. To test this method, both the treed and standard methods were applied to the bifurcating response of a Duffing oscillator and a bifurcating FE model of a heart valve. It was found that the treed Gaussian process provides a practical way of performing uncertainty and sensitivity analysis on large, potentially-bifurcating models, which cannot be dealt with by using a single GP, although an open problem remains how to manage bifurcation boundaries that are not parallel to coordinate axes.

  7. A Post-Monte-Carlo Sensitivity Analysis Code

    2000-04-04

    SATOOL (Sensitivity Analysis TOOL) is a code for sensitivity analysis, following an uncertainity analysis with Monte Carlo simulations. Sensitivity analysis identifies those input variables, whose variance contributes dominatly to the variance in the output. This analysis can be used to reduce the variance in the output variables by redefining the "sensitive" variables with greater precision, i.e. with lower variance. The code identifies a group of sensitive variables, ranks them in the order of importance andmore » also quantifies the relative importance among the sensitive variables.« less

  8. Design sensitivity analysis of rotorcraft airframe structures for vibration reduction

    NASA Technical Reports Server (NTRS)

    Murthy, T. Sreekanta

    1987-01-01

    Optimization of rotorcraft structures for vibration reduction was studied. The objective of this study is to develop practical computational procedures for structural optimization of airframes subject to steady-state vibration response constraints. One of the key elements of any such computational procedure is design sensitivity analysis. A method for design sensitivity analysis of airframes under vibration response constraints is presented. The mathematical formulation of the method and its implementation as a new solution sequence in MSC/NASTRAN are described. The results of the application of the method to a simple finite element stick model of the AH-1G helicopter airframe are presented and discussed. Selection of design variables that are most likely to bring about changes in the response at specified locations in the airframe is based on consideration of forced response strain energy. Sensitivity coefficients are determined for the selected design variable set. Constraints on the natural frequencies are also included in addition to the constraints on the steady-state response. Sensitivity coefficients for these constraints are determined. Results of the analysis and insights gained in applying the method to the airframe model are discussed. The general nature of future work to be conducted is described.

  9. Adjoint-based sensitivity analysis for reactor safety applications

    SciTech Connect

    Parks, C.V.

    1986-08-01

    The application and usefulness of an adjoint-based methodology for performing sensitivity analysis on reactor safety computer codes is investigated. The adjoint-based methodology, referred to as differential sensitivity theory (DST), provides first-order derivatives of the calculated quantities of interest (responses) with respect to the input parameters. The basic theoretical development of DST is presented along with the needed general extensions for consideration of model discontinuities and a variety of useful response definitions. A simple analytic problem is used to highlight the general DST procedures. finally, DST procedures presented in this work are applied to two highly nonlinear reactor accident analysis codes: (1) FASTGAS, a relatively small code for analysis of a loss-of-decay-heat-removal accident in a gas-cooled fast reactor, and (2) an existing code called VENUS-II which has been employed for analyzing the core disassembly phase of a hypothetical fast reactor accident. The two codes are different both in terms of complexity and in terms of the facets of DST which can be illustrated. Sensitivity results from the adjoint codes ADJGAS and VENUS-ADJ are verified with direct recalcualtions using perturbed input parameters. The effectiveness of the DST results for parameter ranking, prediction of response changes, and uncertainty analysis are illustrated. The conclusion drawn from this study is that DST is a viable, cost-effective methodology for accurate sensitivity analysis. In addition, a useful sensitivity tool for use in the fast reactor safety area has been developed in VENUS-ADJ. Future work needs to concentrate on combining the accurate first-order derivatives/results from DST with existing methods (based solely on direct recalculations) for higher-order response surfaces.

  10. Carbon flux from plants to soil microbes is highly sensitive to nitrogen addition and biochar amendment

    NASA Astrophysics Data System (ADS)

    Kaiser, C.; Solaiman, Z. M.; Kilburn, M. R.; Clode, P. L.; Fuchslueger, L.; Koranda, M.; Murphy, D. V.

    2012-04-01

    The release of carbon through plant roots to the soil has been recognized as a governing factor for soil microbial community composition and decomposition processes, constituting an important control for ecosystem biogeochemical cycles. Moreover, there is increasing awareness that the flux of recently assimilated carbon from plants to the soil may regulate ecosystem response to environmental change, as the rate of the plant-soil carbon transfer will likely be affected by increased plant C assimilation caused by increasing atmospheric CO2 levels. What has received less attention so far is how sensitive the plant-soil C transfer would be to possible regulations coming from belowground, such as soil N addition or microbial community changes resulting from anthropogenic inputs such as biochar amendments. In this study we investigated the size, rate and sensitivity of the transfer of recently assimilated plant C through the root-soil-mycorrhiza-microbial continuum. Wheat plants associated with arbuscular mycorrhizal fungi were grown in split-boxes which were filled either with soil or a soil-biochar mixture. Each split-box consisted of two compartments separated by a membrane which was penetrable for mycorrhizal hyphae but not for roots. Wheat plants were only grown in one compartment while the other compartment served as an extended soil volume which was only accessible by mycorrhizal hyphae associated with the plant roots. After plants were grown for four weeks we used a double-labeling approach with 13C and 15N in order to investigate interactions between C and N flows in the plant-soil-microorganism system. Plants were subjected to an enriched 13CO2 atmosphere for 8 hours during which 15NH4 was added to a subset of split-boxes to either the root-containing or the root-free compartment. Both, 13C and 15N fluxes through the plant-soil continuum were monitored over 24 hours by stable isotope methods (13C phospho-lipid fatty acids by GC-IRMS, 15N/13C in bulk plant

  11. Additional EIPC Study Analysis: Interim Report on High Priority Topics

    SciTech Connect

    Hadley, Stanton W

    2013-11-01

    Between 2010 and 2012 the Eastern Interconnection Planning Collaborative (EIPC) conducted a major long-term resource and transmission study of the Eastern Interconnection (EI). With guidance from a Stakeholder Steering Committee (SSC) that included representatives from the Eastern Interconnection States Planning Council (EISPC) among others, the project was conducted in two phases. Phase 1 involved a long-term capacity expansion analysis that involved creation of eight major futures plus 72 sensitivities. Three scenarios were selected for more extensive transmission- focused evaluation in Phase 2. Five power flow analyses, nine production cost model runs (including six sensitivities), and three capital cost estimations were developed during this second phase. The results from Phase 1 and 2 provided a wealth of data that could be examined further to address energy-related questions. A list of 13 topics was developed for further analysis; this paper discusses the first five.

  12. Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats.

    PubMed

    Yang, Hye Jeong; Kwon, Dae Young; Kim, Min Jung; Kang, Suna; Kim, Da Sol; Park, Sunmin

    2012-01-01

    Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) both modulate energy and glucose metabolism. However, the mechanism and their additive effects are unknown. We investigated whether the consumption of HTL and CKJ altered insulin sensitivity, insulin secretion capacity and β-cell survival in type 2 diabetic animals. Rats were divided into partially pancreatectomized (Px) diabetic rats, and sham operated non-diabetic control rats and all fed high fat diets. Diabetic rats were sub-divided into an untreated diabetic control group and those fed 5% HTL, 5% CKJ or 5% HTL+5% CKJ for 8 weeks. HTL+CKJ treatment reduced visceral fat without modulating energy intake compared to the diabetic-control. Glucose tolerance was improved in an ascending order of diabetic-control, CKJ, HTL, HTL+CKJ, and normal-control, but by different mechanisms. CKJ and CKJ+HTL, but not HTL, increased first and second phase insulin secretion in comparison to the diabetic-control at hyperglycemic clamp. However, glucose infusion rates (mg/kg bw/min) were increased by and CKJ+HTL (13.5), but not HTL (9.4) or CKJ (9.5) alone, and HTL and CKJ+ HTL decreased hepatic glucose compared to diabetic-control during the hyperinsulinemic euglycemic study and were associated with decreased triglyceride accumulation and increased glycogen storage. The improved hepatic insulin sensitivity by HTL and CKJ+HTL was explained by potentiated insulin signaling (tyrosine phosphorylation of insulin receptor substrate 2→phosphorylation of Akt) and phosphorylation of AMPK→phosphorykation of acetyl Co carboxlase in comparison to diabetic-control and decreased PEPCK expression. Absolute β-cell mass was increased by CKJ (23.4mg) and CKJ+HTL (26.3 mg) by increasing proliferation compared to the diabetic-control (21.26 mg). Although HTL lowered β-cell apoptosis, it did not increase β-cell mass (20.8 mg). In conclusions, HTL and CKJ enhanced glucose tolerance in different

  13. Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats

    PubMed Central

    2012-01-01

    Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) both modulate energy and glucose metabolism. However, the mechanism and their additive effects are unknown. We investigated whether the consumption of HTL and CKJ altered insulin sensitivity, insulin secretion capacity and β-cell survival in type 2 diabetic animals. Rats were divided into partially pancreatectomized (Px) diabetic rats, and sham operated non-diabetic control rats and all fed high fat diets. Diabetic rats were sub-divided into an untreated diabetic control group and those fed 5% HTL, 5% CKJ or 5% HTL+5% CKJ for 8 weeks. HTL+CKJ treatment reduced visceral fat without modulating energy intake compared to the diabetic-control. Glucose tolerance was improved in an ascending order of diabetic-control, CKJ, HTL, HTL+CKJ, and normal-control, but by different mechanisms. CKJ and CKJ+HTL, but not HTL, increased first and second phase insulin secretion in comparison to the diabetic-control at hyperglycemic clamp. However, glucose infusion rates (mg/kg bw/min) were increased by and CKJ+HTL (13.5), but not HTL (9.4) or CKJ (9.5) alone, and HTL and CKJ+ HTL decreased hepatic glucose compared to diabetic-control during the hyperinsulinemic euglycemic study and were associated with decreased triglyceride accumulation and increased glycogen storage. The improved hepatic insulin sensitivity by HTL and CKJ+HTL was explained by potentiated insulin signaling (tyrosine phosphorylation of insulin receptor substrate 2→phosphorylation of Akt) and phosphorylation of AMPK→phosphorykation of acetyl Co carboxlase in comparison to diabetic-control and decreased PEPCK expression. Absolute β-cell mass was increased by CKJ (23.4mg) and CKJ+HTL (26.3 mg) by increasing proliferation compared to the diabetic-control (21.26 mg). Although HTL lowered β-cell apoptosis, it did not increase β-cell mass (20.8 mg). In conclusions, HTL and CKJ enhanced glucose tolerance in different

  14. Sensitivity analysis of transport modeling in a fractured gneiss aquifer

    NASA Astrophysics Data System (ADS)

    Abdelaziz, Ramadan; Merkel, Broder J.

    2015-03-01

    Modeling solute transport in fractured aquifers is still challenging for scientists and engineers. Tracer tests are a powerful tool to investigate fractured aquifers with complex geometry and variable heterogeneity. This research focuses on obtaining hydraulic and transport parameters from an experimental site with several wells. At the site, a tracer test with NaCl was performed under natural gradient conditions. Observed concentrations of tracer test were used to calibrate a conservative solute transport model by inverse modeling based on UCODE2013, MODFLOW, and MT3DMS. In addition, several statistics are employed for sensitivity analysis. Sensitivity analysis results indicate that hydraulic conductivity and immobile porosity play important role in the late arrive for breakthrough curve. The results proved that the calibrated model fits well with the observed data set.

  15. Stochastic Simulations and Sensitivity Analysis of Plasma Flow

    SciTech Connect

    Lin, Guang; Karniadakis, George E.

    2008-08-01

    For complex physical systems with large number of random inputs, it will be very expensive to perform stochastic simulations for all of the random inputs. Stochastic sensitivity analysis is introduced in this paper to rank the significance of random inputs, provide information on which random input has more influence on the system outputs and the coupling or interaction effect among different random inputs. There are two types of numerical methods in stochastic sensitivity analysis: local and global methods. The local approach, which relies on a partial derivative of output with respect to parameters, is used to measure the sensitivity around a local operating point. When the system has strong nonlinearities and parameters fluctuate within a wide range from their nominal values, the local sensitivity does not provide full information to the system operators. On the other side, the global approach examines the sensitivity from the entire range of the parameter variations. The global screening methods, based on One-At-a-Time (OAT) perturbation of parameters, rank the significant parameters and identify their interaction among a large number of parameters. Several screening methods have been proposed in literature, i.e., the Morris method, Cotter's method, factorial experimentation, and iterated fractional factorial design. In this paper, the Morris method, Monte Carlo sampling method, Quasi-Monte Carlo method and collocation method based on sparse grids are studied. Additionally, two MHD examples are presented to demonstrate the capability and efficiency of the stochastic sensitivity analysis, which can be used as a pre-screening technique for reducing the dimensionality and hence the cost in stochastic simulations.

  16. Global sensitivity analysis of groundwater transport

    NASA Astrophysics Data System (ADS)

    Cvetkovic, V.; Soltani, S.; Vigouroux, G.

    2015-12-01

    In this work we address the model and parametric sensitivity of groundwater transport using the Lagrangian-Stochastic Advection-Reaction (LaSAR) methodology. The 'attenuation index' is used as a relevant and convenient measure of the coupled transport mechanisms. The coefficients of variation (CV) for seven uncertain parameters are assumed to be between 0.25 and 3.5, the highest value being for the lower bound of the mass transfer coefficient k0 . In almost all cases, the uncertainties in the macro-dispersion (CV = 0.35) and in the mass transfer rate k0 (CV = 3.5) are most significant. The global sensitivity analysis using Sobol and derivative-based indices yield consistent rankings on the significance of different models and/or parameter ranges. The results presented here are generic however the proposed methodology can be easily adapted to specific conditions where uncertainty ranges in models and/or parameters can be estimated from field and/or laboratory measurements.

  17. Multicomponent dynamical nucleation theory and sensitivity analysis.

    PubMed

    Kathmann, Shawn M; Schenter, Gregory K; Garrett, Bruce C

    2004-05-15

    Vapor to liquid multicomponent nucleation is a dynamical process governed by a delicate interplay between condensation and evaporation. Since the population of the vapor phase is dominated by monomers at reasonable supersaturations, the formation of clusters is governed by monomer association and dissociation reactions. Although there is no intrinsic barrier in the interaction potential along the minimum energy path for the association process, the formation of a cluster is impeded by a free energy barrier. Dynamical nucleation theory provides a framework in which equilibrium evaporation rate constants can be calculated and the corresponding condensation rate constants determined from detailed balance. The nucleation rate can then be obtained by solving the kinetic equations. The rate constants governing the multistep kinetics of multicomponent nucleation including sensitivity analysis and the potential influence of contaminants will be presented and discussed. PMID:15267849

  18. Sensitivity analysis of periodic matrix population models.

    PubMed

    Caswell, Hal; Shyu, Esther

    2012-12-01

    Periodic matrix models are frequently used to describe cyclic temporal variation (seasonal or interannual) and to account for the operation of multiple processes (e.g., demography and dispersal) within a single projection interval. In either case, the models take the form of periodic matrix products. The perturbation analysis of periodic models must trace the effects of parameter changes, at each phase of the cycle, on output variables that are calculated over the entire cycle. Here, we apply matrix calculus to obtain the sensitivity and elasticity of scalar-, vector-, or matrix-valued output variables. We apply the method to linear models for periodic environments (including seasonal harvest models), to vec-permutation models in which individuals are classified by multiple criteria, and to nonlinear models including both immediate and delayed density dependence. The results can be used to evaluate management strategies and to study selection gradients in periodic environments. PMID:23316494

  19. Sensitivity analysis of distributed volcanic source inversion

    NASA Astrophysics Data System (ADS)

    Cannavo', Flavio; Camacho, Antonio G.; González, Pablo J.; Puglisi, Giuseppe; Fernández, José

    2016-04-01

    A recently proposed algorithm (Camacho et al., 2011) claims to rapidly estimate magmatic sources from surface geodetic data without any a priori assumption about source geometry. The algorithm takes the advantages of fast calculation from the analytical models and adds the capability to model free-shape distributed sources. Assuming homogenous elastic conditions, the approach can determine general geometrical configurations of pressured and/or density source and/or sliding structures corresponding to prescribed values of anomalous density, pressure and slip. These source bodies are described as aggregation of elemental point sources for pressure, density and slip, and they fit the whole data (keeping some 3D regularity conditions). Although some examples and applications have been already presented to demonstrate the ability of the algorithm in reconstructing a magma pressure source (e.g. Camacho et al., 2011,Cannavò et al., 2015), a systematic analysis of sensitivity and reliability of the algorithm is still lacking. In this explorative work we present results from a large statistical test designed to evaluate the advantages and limitations of the methodology by assessing its sensitivity to the free and constrained parameters involved in inversions. In particular, besides the source parameters, we focused on the ground deformation network topology, and noise in measurements. The proposed analysis can be used for a better interpretation of the algorithm results in real-case applications. Camacho, A. G., González, P. J., Fernández, J. & Berrino, G. (2011) Simultaneous inversion of surface deformation and gravity changes by means of extended bodies with a free geometry: Application to deforming calderas. J. Geophys. Res. 116. Cannavò F., Camacho A.G., González P.J., Mattia M., Puglisi G., Fernández J. (2015) Real Time Tracking of Magmatic Intrusions by means of Ground Deformation Modeling during Volcanic Crises, Scientific Reports, 5 (10970) doi:10.1038/srep

  20. Variable Temperature Stress in the Nematode Caenorhabditis elegans (Maupas) and Its Implications for Sensitivity to an Additional Chemical Stressor

    PubMed Central

    Svendsen, Claus; Spurgeon, David J.

    2016-01-01

    A wealth of studies has investigated how chemical sensitivity is affected by temperature, however, almost always under different constant rather than more realistic fluctuating regimes. Here we compared how the nematode Caenorhabditis elegans responds to copper at constant temperatures (8–24°C) and under fluctuation conditions of low (±4°C) and high (±8°C) amplitude (averages of 12, 16, 20°C and 16°C respectively). The DEBkiss model was used to interpret effects on energy budgets. Increasing constant temperature from 12–24°C reduced time to first egg, life-span and population growth rates consistent with temperature driven metabolic rate change. Responses at 8°C did not, however, accord with this pattern (including a deviation from the Temperature Size Rule), identifying a cold stress effect. High amplitude variation and low amplitude variation around a mean temperature of 12°C impacted reproduction and body size compared to nematodes kept at the matching average constant temperatures. Copper exposure affected reproduction, body size and life-span and consequently population growth. Sensitivity to copper (EC50 values), was similar at intermediate temperatures (12, 16, 20°C) and higher at 24°C and especially the innately stressful 8°C condition. Temperature variation did not increase copper sensitivity. Indeed under variable conditions including time at the stressful 8°C condition, sensitivity was reduced. DEBkiss identified increased maintenance costs and increased assimilation as possible mechanisms for cold and higher copper concentration effects. Model analysis of combined variable temperature effects, however, demonstrated no additional joint stressor response. Hence, concerns that exposure to temperature fluctuations may sensitise species to co-stressor effects seem unfounded in this case. PMID:26784453

  1. Variable Temperature Stress in the Nematode Caenorhabditis elegans (Maupas) and Its Implications for Sensitivity to an Additional Chemical Stressor.

    PubMed

    Cedergreen, Nina; Nørhave, Nils Jakob; Svendsen, Claus; Spurgeon, David J

    2016-01-01

    A wealth of studies has investigated how chemical sensitivity is affected by temperature, however, almost always under different constant rather than more realistic fluctuating regimes. Here we compared how the nematode Caenorhabditis elegans responds to copper at constant temperatures (8-24°C) and under fluctuation conditions of low (±4°C) and high (±8°C) amplitude (averages of 12, 16, 20°C and 16°C respectively). The DEBkiss model was used to interpret effects on energy budgets. Increasing constant temperature from 12-24°C reduced time to first egg, life-span and population growth rates consistent with temperature driven metabolic rate change. Responses at 8°C did not, however, accord with this pattern (including a deviation from the Temperature Size Rule), identifying a cold stress effect. High amplitude variation and low amplitude variation around a mean temperature of 12°C impacted reproduction and body size compared to nematodes kept at the matching average constant temperatures. Copper exposure affected reproduction, body size and life-span and consequently population growth. Sensitivity to copper (EC50 values), was similar at intermediate temperatures (12, 16, 20°C) and higher at 24°C and especially the innately stressful 8°C condition. Temperature variation did not increase copper sensitivity. Indeed under variable conditions including time at the stressful 8°C condition, sensitivity was reduced. DEBkiss identified increased maintenance costs and increased assimilation as possible mechanisms for cold and higher copper concentration effects. Model analysis of combined variable temperature effects, however, demonstrated no additional joint stressor response. Hence, concerns that exposure to temperature fluctuations may sensitise species to co-stressor effects seem unfounded in this case. PMID:26784453

  2. Additive toxicity of herbicide mixtures and comparative sensitivity of tropical benthic microalgae.

    PubMed

    Magnusson, Marie; Heimann, Kirsten; Quayle, Pamela; Negri, Andrew P

    2010-11-01

    Natural waters often contain complex mixtures of unknown contaminants potentially posing a threat to marine communities through chemical interactions. Here, acute effects of the photosystem II-inhibiting herbicides diuron, tebuthiuron, atrazine, simazine, and hexazinone, herbicide breakdown products (desethyl-atrazine (DEA) and 3,4-dichloroaniline (3,4-DCA)) and binary mixtures, were investigated using three tropical benthic microalgae; Navicula sp. and Cylindrotheca closterium (Ochrophyta) and Nephroselmis pyriformis (Chlorophyta), and one standard test species, Phaeodactylum tricornutum (Ochrophyta), in a high-throughput Maxi-Imaging-PAM bioassay (Maxi-IPAM). The order of toxicity was; diuron > hexazinone > tebuthiuron > atrazine > simazine > DEA > 3,4-DCA for all species. The tropical green alga N. pyriformis was up to 10-fold more sensitive than the diatoms tested here and reported for coral symbionts, and is recommended as a standard tropical test species for future research. All binary mixtures exhibited additive toxicity, and the use of herbicide equivalents (HEq) is therefore recommended in order to incorporate total-maximum-load measures for environmental regulatory purposes. PMID:20800855

  3. Computed Tomography Inspection and Analysis for Additive Manufacturing Components

    NASA Technical Reports Server (NTRS)

    Beshears, Ronald D.

    2016-01-01

    Computed tomography (CT) inspection was performed on test articles additively manufactured from metallic materials. Metallic AM and machined wrought alloy test articles with programmed flaws were inspected using a 2MeV linear accelerator based CT system. Performance of CT inspection on identically configured wrought and AM components and programmed flaws was assessed using standard image analysis techniques to determine the impact of additive manufacturing on inspectability of objects with complex geometries.

  4. Sensitivity to food additives, vaso-active amines and salicylates: a review of the evidence.

    PubMed

    Skypala, Isabel J; Williams, M; Reeves, L; Meyer, R; Venter, C

    2015-01-01

    Although there is considerable literature pertaining to IgE and non IgE-mediated food allergy, there is a paucity of information on non-immune mediated reactions to foods, other than metabolic disorders such as lactose intolerance. Food additives and naturally occurring 'food chemicals' have long been reported as having the potential to provoke symptoms in those who are more sensitive to their effects. Diets low in 'food chemicals' gained prominence in the 1970s and 1980s, and their popularity remains, although the evidence of their efficacy is very limited. This review focuses on the available evidence for the role and likely adverse effects of both added and natural 'food chemicals' including benzoate, sulphite, monosodium glutamate, vaso-active or biogenic amines and salicylate. Studies assessing the efficacy of the restriction of these substances in the diet have mainly been undertaken in adults, but the paper will also touch on the use of such diets in children. The difficulty of reviewing the available evidence is that few of the studies have been controlled and, for many, considerable time has elapsed since their publication. Meanwhile dietary patterns and habits have changed hugely in the interim, so the conclusions may not be relevant for our current dietary norms. The conclusion of the review is that there may be some benefit in the removal of an additive or a group of foods high in natural food chemicals from the diet for a limited period for certain individuals, providing the diagnostic pathway is followed and the foods are reintroduced back into the diet to assess for the efficacy of removal. However diets involving the removal of multiple additives and food chemicals have the very great potential to lead to nutritional deficiency especially in the paediatric population. Any dietary intervention, whether for the purposes of diagnosis or management of food allergy or food intolerance, should be adapted to the individual's dietary habits and a suitably

  5. Longitudinal Genetic Analysis of Anxiety Sensitivity

    ERIC Educational Resources Information Center

    Zavos, Helena M. S.; Gregory, Alice M.; Eley, Thalia C.

    2012-01-01

    Anxiety sensitivity is associated with both anxiety and depression and has been shown to be heritable. Little, however, is known about the role of genetic influence on continuity and change of symptoms over time. The authors' aim was to examine the stability of anxiety sensitivity during adolescence. By using a genetically sensitive design, the…

  6. Objective analysis of the ARM IOP data: method and sensitivity

    SciTech Connect

    Cedarwall, R; Lin, J L; Xie, S C; Yio, J J; Zhang, M H

    1999-04-01

    Motivated by the need of to obtain accurate objective analysis of field experimental data to force physical parameterizations in numerical models, this paper -first reviews the existing objective analysis methods and interpolation schemes that are used to derive atmospheric wind divergence, vertical velocity, and advective tendencies. Advantages and disadvantages of each method are discussed. It is shown that considerable uncertainties in the analyzed products can result from the use of different analysis schemes and even more from different implementations of a particular scheme. The paper then describes a hybrid approach to combine the strengths of the regular grid method and the line-integral method, together with a variational constraining procedure for the analysis of field experimental data. In addition to the use of upper air data, measurements at the surface and at the top-of-the-atmosphere are used to constrain the upper air analysis to conserve column-integrated mass, water, energy, and momentum. Analyses are shown for measurements taken in the Atmospheric Radiation Measurement Programs (ARM) July 1995 Intensive Observational Period (IOP). Sensitivity experiments are carried out to test the robustness of the analyzed data and to reveal the uncertainties in the analysis. It is shown that the variational constraining process significantly reduces the sensitivity of the final data products.

  7. Global sensitivity analysis in wind energy assessment

    NASA Astrophysics Data System (ADS)

    Tsvetkova, O.; Ouarda, T. B.

    2012-12-01

    Wind energy is one of the most promising renewable energy sources. Nevertheless, it is not yet a common source of energy, although there is enough wind potential to supply world's energy demand. One of the most prominent obstacles on the way of employing wind energy is the uncertainty associated with wind energy assessment. Global sensitivity analysis (SA) studies how the variation of input parameters in an abstract model effects the variation of the variable of interest or the output variable. It also provides ways to calculate explicit measures of importance of input variables (first order and total effect sensitivity indices) in regard to influence on the variation of the output variable. Two methods of determining the above mentioned indices were applied and compared: the brute force method and the best practice estimation procedure In this study a methodology for conducting global SA of wind energy assessment at a planning stage is proposed. Three sampling strategies which are a part of SA procedure were compared: sampling based on Sobol' sequences (SBSS), Latin hypercube sampling (LHS) and pseudo-random sampling (PRS). A case study of Masdar City, a showcase of sustainable living in the UAE, is used to exemplify application of the proposed methodology. Sources of uncertainty in wind energy assessment are very diverse. In the case study the following were identified as uncertain input parameters: the Weibull shape parameter, the Weibull scale parameter, availability of a wind turbine, lifetime of a turbine, air density, electrical losses, blade losses, ineffective time losses. Ineffective time losses are defined as losses during the time when the actual wind speed is lower than the cut-in speed or higher than the cut-out speed. The output variable in the case study is the lifetime energy production. Most influential factors for lifetime energy production are identified with the ranking of the total effect sensitivity indices. The results of the present

  8. Sensitivity Analysis of Wing Aeroelastic Responses

    NASA Technical Reports Server (NTRS)

    Issac, Jason Cherian

    1995-01-01

    Design for prevention of aeroelastic instability (that is, the critical speeds leading to aeroelastic instability lie outside the operating range) is an integral part of the wing design process. Availability of the sensitivity derivatives of the various critical speeds with respect to shape parameters of the wing could be very useful to a designer in the initial design phase, when several design changes are made and the shape of the final configuration is not yet frozen. These derivatives are also indispensable for a gradient-based optimization with aeroelastic constraints. In this study, flutter characteristic of a typical section in subsonic compressible flow is examined using a state-space unsteady aerodynamic representation. The sensitivity of the flutter speed of the typical section with respect to its mass and stiffness parameters, namely, mass ratio, static unbalance, radius of gyration, bending frequency, and torsional frequency is calculated analytically. A strip theory formulation is newly developed to represent the unsteady aerodynamic forces on a wing. This is coupled with an equivalent plate structural model and solved as an eigenvalue problem to determine the critical speed of the wing. Flutter analysis of the wing is also carried out using a lifting-surface subsonic kernel function aerodynamic theory (FAST) and an equivalent plate structural model. Finite element modeling of the wing is done using NASTRAN so that wing structures made of spars and ribs and top and bottom wing skins could be analyzed. The free vibration modes of the wing obtained from NASTRAN are input into FAST to compute the flutter speed. An equivalent plate model which incorporates first-order shear deformation theory is then examined so it can be used to model thick wings, where shear deformations are important. The sensitivity of natural frequencies to changes in shape parameters is obtained using ADIFOR. A simple optimization effort is made towards obtaining a minimum weight

  9. Optimal Multicomponent Analysis Using the Generalized Standard Addition Method.

    ERIC Educational Resources Information Center

    Raymond, Margaret; And Others

    1983-01-01

    Describes an experiment on the simultaneous determination of chromium and magnesium by spectophotometry modified to include the Generalized Standard Addition Method computer program, a multivariate calibration method that provides optimal multicomponent analysis in the presence of interference and matrix effects. Provides instructions for…

  10. Design and implementation of a context-sensitive, flow-sensitive activity analysis algorithm for automatic differentiation.

    SciTech Connect

    Shin, J.; Malusare, P.; Hovland, P. D.; Mathematics and Computer Science

    2008-01-01

    Automatic differentiation (AD) has been expanding its role in scientific computing. While several AD tools have been actively developed and used, a wide range of problems remain to be solved. Activity analysis allows AD tools to generate derivative code for fewer variables, leading to a faster run time of the output code. This paper describes a new context-sensitive, flow-sensitive (CSFS) activity analysis, which is developed by extending an existing context-sensitive, flow-insensitive (CSFI) activity analysis. Our experiments with eight benchmarks show that the new CSFS activity analysis is more than 27 times slower but reduces 8 overestimations for the MIT General Circulation Model (MITgcm) and 1 for an ODE solver (c2) compared with the existing CSFI activity analysis implementation. Although the number of reduced overestimations looks small, the additionally identified passive variables may significantly reduce tedious human effort in maintaining a large code base such as MITgcm.

  11. Analysis of Saccharides by the Addition of Amino Acids

    NASA Astrophysics Data System (ADS)

    Ozdemir, Abdil; Lin, Jung-Lee; Gillig, Kent J.; Gulfen, Mustafa; Chen, Chung-Hsuan

    2016-06-01

    In this work, we present the detection sensitivity improvement of electrospray ionization (ESI) mass spectrometry of neutral saccharides in a positive ion mode by the addition of various amino acids. Saccharides of a broad molecular weight range were chosen as the model compounds in the present study. Saccharides provide strong noncovalent interactions with amino acids, and the complex formation enhances the signal intensity and simplifies the mass spectra of saccharides. Polysaccharides provide a polymer-like ESI spectrum with a basic subunit difference between multiply charged chains. The protonated spectra of saccharides are not well identified because of different charge state distributions produced by the same molecules. Depending on the solvent used and other ions or molecules present in the solution, noncovalent interactions with saccharides may occur. These interactions are affected by the addition of amino acids. Amino acids with polar side groups show a strong tendency to interact with saccharides. In particular, serine shows a high tendency to interact with saccharides and significantly improves the detection sensitivity of saccharide compounds.

  12. Sensitive LC MS quantitative analysis of carbohydrates by Cs+ attachment.

    PubMed

    Rogatsky, Eduard; Jayatillake, Harsha; Goswami, Gayotri; Tomuta, Vlad; Stein, Daniel

    2005-11-01

    The development of a sensitive assay for the quantitative analysis of carbohydrates from human plasma using LC/MS/MS is described in this paper. After sample preparation, carbohydrates were cationized by Cs(+) after their separation by normal phase liquid chromatography on an amino based column. Cesium is capable of forming a quasi-molecular ion [M + Cs](+) with neutral carbohydrate molecules in the positive ion mode of electrospray ionization mass spectrometry. The mass spectrometer was operated in multiple reaction monitoring mode, and transitions [M + 133] --> 133 were monitored (M, carbohydrate molecular weight). The new method is robust, highly sensitive, rapid, and does not require postcolumn addition or derivatization. It is useful in clinical research for measurement of carbohydrate molecules by isotope dilution assay. PMID:16182559

  13. Sensitivity alteration of fiber Bragg grating sensors with additive micro-scale bi-material coatings

    NASA Astrophysics Data System (ADS)

    Zhang, Xixi; Alemohammad, Hamidreza; Toyserkani, Ehsan

    2013-02-01

    This paper describes a combined fabrication method for creating a bi-material micro-scale coating on fiber Bragg grating (FBG) optical sensors using laser-assisted maskless microdeposition (LAMM) and electroless nickel plating. This bi-material coating alters the sensitivity of the sensor where it also acts as a protective layer. LAMM is used to coat bare FBGs with a 1-2 µm thick conductive silver layer followed by the electroless nickel plating process to increase layer thickness to a desired level ranging from 1 to 80 µm. To identify an optimum coating thickness and predict its effect on the sensor's sensitivity to force and temperature, an optomechanical model is developed in this study. According to the model if the thickness of the Ni layer is 30-50 µm, maximum temperature sensitivity is achieved. Our analytical and experimental results suggest that the temperature sensitivity of the coated FBG with 1 µm Ag and 33 µm Ni is almost doubled compared to a bare FBG with sensitivity of 0.011 ± 0.001 nm °C-1. In contrast, the force sensitivity is decreased; however, this sensitivity reduction is less than the values reported in the literature.

  14. Wear-Out Sensitivity Analysis Project Abstract

    NASA Technical Reports Server (NTRS)

    Harris, Adam

    2015-01-01

    During the course of the Summer 2015 internship session, I worked in the Reliability and Maintainability group of the ISS Safety and Mission Assurance department. My project was a statistical analysis of how sensitive ORU's (Orbital Replacement Units) are to a reliability parameter called the wear-out characteristic. The intended goal of this was to determine a worst case scenario of how many spares would be needed if multiple systems started exhibiting wear-out characteristics simultaneously. The goal was also to determine which parts would be most likely to do so. In order to do this, my duties were to take historical data of operational times and failure times of these ORU's and use them to build predictive models of failure using probability distribution functions, mainly the Weibull distribution. Then, I ran Monte Carlo Simulations to see how an entire population of these components would perform. From here, my final duty was to vary the wear-out characteristic from the intrinsic value, to extremely high wear-out values and determine how much the probability of sufficiency of the population would shift. This was done for around 30 different ORU populations on board the ISS.

  15. Sensitivity analysis of volume scattering phase functions.

    PubMed

    Tuchow, Noah; Broughton, Jennifer; Kudela, Raphael

    2016-08-01

    To solve the radiative transfer equation and relate inherent optical properties (IOPs) to apparent optical properties (AOPs), knowledge of the volume scattering phase function is required. Due to the difficulty of measuring the phase function, it is frequently approximated. We explore the sensitivity of derived AOPs to the phase function parameterization, and compare measured and modeled values of both the AOPs and estimated phase functions using data from Monterey Bay, California during an extreme "red tide" bloom event. Using in situ measurements of absorption and attenuation coefficients, as well as two sets of measurements of the volume scattering function (VSF), we compared output from the Hydrolight radiative transfer model to direct measurements. We found that several common assumptions used in parameterizing the radiative transfer model consistently introduced overestimates of modeled versus measured remote-sensing reflectance values. Phase functions from VSF data derived from measurements at multiple wavelengths and a single scattering single angle significantly overestimated reflectances when using the manufacturer-supplied corrections, but were substantially improved using newly published corrections; phase functions calculated from VSF measurements using three angles and three wavelengths and processed using manufacture-supplied corrections were comparable, demonstrating that reasonable predictions can be made using two commercially available instruments. While other studies have reached similar conclusions, our work extends the analysis to coastal waters dominated by an extreme algal bloom with surface chlorophyll concentrations in excess of 100 mg m-3. PMID:27505819

  16. Tilt-Sensitivity Analysis for Space Telescopes

    NASA Technical Reports Server (NTRS)

    Papalexandris, Miltiadis; Waluschka, Eugene

    2003-01-01

    A report discusses a computational-simulation study of phase-front propagation in the Laser Interferometer Space Antenna (LISA), in which space telescopes would transmit and receive metrological laser beams along 5-Gm interferometer arms. The main objective of the study was to determine the sensitivity of the average phase of a beam with respect to fluctuations in pointing of the beam. The simulations account for the effects of obscurations by a secondary mirror and its supporting struts in a telescope, and for the effects of optical imperfections (especially tilt) of a telescope. A significant innovation introduced in this study is a methodology, applicable to space telescopes in general, for predicting the effects of optical imperfections. This methodology involves a Monte Carlo simulation in which one generates many random wavefront distortions and studies their effects through computational simulations of propagation. Then one performs a statistical analysis of the results of the simulations and computes the functional relations among such important design parameters as the sizes of distortions and the mean value and the variance of the loss of performance. These functional relations provide information regarding position and orientation tolerances relevant to design and operation.

  17. Controlling the Electrostatic Discharge Ignition Sensitivity of Composite Energetic Materials Using Carbon Nanotube Additives

    SciTech Connect

    Kade H. Poper; Eric S. Collins; Michelle L. Pantoya; Michael Daniels

    2014-10-01

    Powder energetic materials are highly sensitive to electrostatic discharge (ESD) ignition. This study shows that small concentrations of carbon nanotubes (CNT) added to the highly reactive mixture of aluminum and copper oxide (Al + CuO) significantly reduces ESD ignition sensitivity. CNT act as a conduit for electric energy, bypassing energy buildup and desensitizing the mixture to ESD ignition. The lowest CNT concentration needed to desensitize ignition is 3.8 vol.% corresponding to percolation corresponding to an electrical conductivity of 0.04 S/cm. Conversely, added CNT increased Al + CuO thermal ignition sensitivity to a hot wire igniter.

  18. Sensitivity analysis of hydrodynamic stability operators

    NASA Technical Reports Server (NTRS)

    Schmid, Peter J.; Henningson, Dan S.; Khorrami, Mehdi R.; Malik, Mujeeb R.

    1992-01-01

    The eigenvalue sensitivity for hydrodynamic stability operators is investigated. Classical matrix perturbation techniques as well as the concept of epsilon-pseudoeigenvalues are applied to show that parts of the spectrum are highly sensitive to small perturbations. Applications are drawn from incompressible plane Couette, trailing line vortex flow and compressible Blasius boundary layer flow. Parametric studies indicate a monotonically increasing effect of the Reynolds number on the sensitivity. The phenomenon of eigenvalue sensitivity is due to the non-normality of the operators and their discrete matrix analogs and may be associated with large transient growth of the corresponding initial value problem.

  19. Analysis and Evaluation of Supersonic Underwing Heat Addition

    NASA Technical Reports Server (NTRS)

    Luidens, Roger W.; Flaherty, Richard J.

    1959-01-01

    The linearized theory for heat addition under a wing has been developed to optimize wing geometry, heat addition, and angle of attack. The optimum wing has all of the thickness on the underside of the airfoil, with maximum-thickness point well downstream, has a moderate thickness ratio, and operates at an optimum angle of attack. The heat addition is confined between the fore Mach waves from under the trailing surface of the wing. By linearized theory, a wing at optimum angle of attack may have a range efficiency about twice that of a wing at zero angle of attack. More rigorous calculations using the method of characteristics for particular flow models were made for heating under a flat-plate wing and for several wings with thickness, both with heat additions concentrated near the wing. The more rigorous calculations yield in practical cases efficiencies about half those estimated by linear theory. An analysis indicates that distributing the heat addition between the fore waves from the undertrailing portion of the wing is a way of improving the performance, and further calculations appear desirable. A comparison of the conventional ramjet-plus wing with underwing heat addition when the heat addition is concentrated near the wing shows the ramjet to be superior on a range basis up to Mach number of about B. The heat distribution under the wing and the assumed ramjet and airframe performance may have a marked effect on this conclusion. Underwing heat addition can be useful in providing high-altitude maneuver capability at high flight Mach numbers for an airplane powered by conventional ramjets during cruise.

  20. LSENS, The NASA Lewis Kinetics and Sensitivity Analysis Code

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    2000-01-01

    A general chemical kinetics and sensitivity analysis code for complex, homogeneous, gas-phase reactions is described. The main features of the code, LSENS (the NASA Lewis kinetics and sensitivity analysis code), are its flexibility, efficiency and convenience in treating many different chemical reaction models. The models include: static system; steady, one-dimensional, inviscid flow; incident-shock initiated reaction in a shock tube; and a perfectly stirred reactor. In addition, equilibrium computations can be performed for several assigned states. An implicit numerical integration method (LSODE, the Livermore Solver for Ordinary Differential Equations), which works efficiently for the extremes of very fast and very slow reactions, is used to solve the "stiff" ordinary differential equation systems that arise in chemical kinetics. For static reactions, the code uses the decoupled direct method to calculate sensitivity coefficients of the dependent variables and their temporal derivatives with respect to the initial values of dependent variables and/or the rate coefficient parameters. Solution methods for the equilibrium and post-shock conditions and for perfectly stirred reactor problems are either adapted from or based on the procedures built into the NASA code CEA (Chemical Equilibrium and Applications).

  1. Sensitivity analysis of textural parameters for vertebroplasty

    NASA Astrophysics Data System (ADS)

    Tack, Gye Rae; Lee, Seung Y.; Shin, Kyu-Chul; Lee, Sung J.

    2002-05-01

    Vertebroplasty is one of the newest surgical approaches for the treatment of the osteoporotic spine. Recent studies have shown that it is a minimally invasive, safe, promising procedure for patients with osteoporotic fractures while providing structural reinforcement of the osteoporotic vertebrae as well as immediate pain relief. However, treatment failures due to excessive bone cement injection have been reported as one of complications. It is believed that control of bone cement volume seems to be one of the most critical factors in preventing complications. We believed that an optimal bone cement volume could be assessed based on CT data of a patient. Gray-level run length analysis was used to extract textural information of the trabecular. At initial stage of the project, four indices were used to represent the textural information: mean width of intertrabecular space, mean width of trabecular, area of intertrabecular space, and area of trabecular. Finally, the area of intertrabecular space was selected as a parameter to estimate an optimal bone cement volume and it was found that there was a strong linear relationship between these 2 variables (correlation coefficient = 0.9433, standard deviation = 0.0246). In this study, we examined several factors affecting overall procedures. The threshold level, the radius of rolling ball and the size of region of interest were selected for the sensitivity analysis. As the level of threshold varied with 9, 10, and 11, the correlation coefficient varied from 0.9123 to 0.9534. As the radius of rolling ball varied with 45, 50, and 55, the correlation coefficient varied from 0.9265 to 0.9730. As the size of region of interest varied with 58 x 58, 64 x 64, and 70 x 70, the correlation coefficient varied from 0.9685 to 0.9468. Finally, we found that strong correlation between actual bone cement volume (Y) and the area (X) of the intertrabecular space calculated from the binary image and the linear equation Y = 0.001722 X - 2

  2. Topographic Avalanche Risk: DEM Sensitivity Analysis

    NASA Astrophysics Data System (ADS)

    Nazarkulova, Ainura; Strobl, Josef

    2015-04-01

    GIS-based models are frequently used to assess the risk and trigger probabilities of (snow) avalanche releases, based on parameters and geomorphometric derivatives like elevation, exposure, slope, proximity to ridges and local relief energy. Numerous models, and model-based specific applications and project results have been published based on a variety of approaches and parametrizations as well as calibrations. Digital Elevation Models (DEM) come with many different resolution (scale) and quality (accuracy) properties, some of these resulting from sensor characteristics and DEM generation algorithms, others from different DEM processing workflows and analysis strategies. This paper explores the impact of using different types and characteristics of DEMs for avalanche risk modeling approaches, and aims at establishing a framework for assessing the uncertainty of results. The research question is derived from simply demonstrating the differences in release risk areas and intensities by applying identical models to DEMs with different properties, and then extending this into a broader sensitivity analysis. For the quantification and calibration of uncertainty parameters different metrics are established, based on simple value ranges, probabilities, as well as fuzzy expressions and fractal metrics. As a specific approach the work on DEM resolution-dependent 'slope spectra' is being considered and linked with the specific application of geomorphometry-base risk assessment. For the purpose of this study focusing on DEM characteristics, factors like land cover, meteorological recordings and snowpack structure and transformation are kept constant, i.e. not considered explicitly. Key aims of the research presented here are the development of a multi-resolution and multi-scale framework supporting the consistent combination of large area basic risk assessment with local mitigation-oriented studies, and the transferability of the latter into areas without availability of

  3. [Ecological sensitivity of Shanghai City based on GIS spatial analysis].

    PubMed

    Cao, Jian-jun; Liu, Yong-juan

    2010-07-01

    In this paper, five sensitivity factors affecting the eco-environment of Shanghai City, i.e., rivers and lakes, historical relics and forest parks, geological disasters, soil pollution, and land use, were selected, and their weights were determined by analytic hierarchy process. Combining with GIS spatial analysis technique, the sensitivities of these factors were classified into four grades, i.e., highly sensitive, moderately sensitive, low sensitive, and insensitive, and the spatial distribution of the ecological sensitivity of Shanghai City was figured out. There existed a significant spatial differentiation in the ecological sensitivity of the City, and the insensitive, low sensitive, moderately sensitive, and highly sensitive areas occupied 37.07%, 5.94%, 38.16%, and 18.83%, respectively. Some suggestions on the City's zoning protection and construction were proposed. This study could provide scientific references for the City's environmental protection and economic development. PMID:20879541

  4. ANALYSIS OF MPC ACCESS REQUIREMENTS FOR ADDITION OF FILLER MATERIALS

    SciTech Connect

    W. Wallin

    1996-09-03

    This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development Department (WPDD) in response to a request received via a QAP-3-12 Design Input Data Request (Ref. 5.1) from WAST Design (formerly MRSMPC Design). The request is to provide: Specific MPC access requirements for the addition of filler materials at the MGDS (i.e., location and size of access required). The objective of this analysis is to provide a response to the foregoing request. The purpose of this analysis is to provide a documented record of the basis for the response. The response is stated in Section 8 herein. The response is based upon requirements from an MGDS perspective.

  5. Spectral Envelopes and Additive + Residual Analysis/Synthesis

    NASA Astrophysics Data System (ADS)

    Rodet, Xavier; Schwarz, Diemo

    The subject of this chapter is the estimation, representation, modification, and use of spectral envelopes in the context of sinusoidal-additive-plus-residual analysis/synthesis. A spectral envelope is an amplitude-vs-frequency function, which may be obtained from the envelope of a short-time spectrum (Rodet et al., 1987; Schwarz, 1998). [Precise definitions of such an envelope and short-time spectrum (STS) are given in Section 2.] The additive-plus-residual analysis/synthesis method is based on a representation of signals in terms of a sum of time-varying sinusoids and of a non-sinusoidal residual signal [e.g., see Serra (1989), Laroche et al. (1993), McAulay and Quatieri (1995), and Ding and Qian (1997)]. Many musical sound signals may be described as a combination of a nearly periodic waveform and colored noise. The nearly periodic part of the signal can be viewed as a sum of sinusoidal components, called partials, with time-varying frequency and amplitude. Such sinusoidal components are easily observed on a spectral analysis display (Fig. 5.1) as obtained, for instance, from a discrete Fourier transform.

  6. Extended forward sensitivity analysis of one-dimensional isothermal flow

    SciTech Connect

    Johnson, M.; Zhao, H.

    2013-07-01

    Sensitivity analysis and uncertainty quantification is an important part of nuclear safety analysis. In this work, forward sensitivity analysis is used to compute solution sensitivities on 1-D fluid flow equations typical of those found in system level codes. Time step sensitivity analysis is included as a method for determining the accumulated error from time discretization. The ability to quantify numerical error arising from the time discretization is a unique and important feature of this method. By knowing the relative sensitivity of time step with other physical parameters, the simulation is allowed to run at optimized time steps without affecting the confidence of the physical parameter sensitivity results. The time step forward sensitivity analysis method can also replace the traditional time step convergence studies that are a key part of code verification with much less computational cost. One well-defined benchmark problem with manufactured solutions is utilized to verify the method; another test isothermal flow problem is used to demonstrate the extended forward sensitivity analysis process. Through these sample problems, the paper shows the feasibility and potential of using the forward sensitivity analysis method to quantify uncertainty in input parameters and time step size for a 1-D system-level thermal-hydraulic safety code. (authors)

  7. Grid sensitivity for aerodynamic optimization and flow analysis

    NASA Technical Reports Server (NTRS)

    Sadrehaghighi, I.; Tiwari, S. N.

    1993-01-01

    After reviewing relevant literature, it is apparent that one aspect of aerodynamic sensitivity analysis, namely grid sensitivity, has not been investigated extensively. The grid sensitivity algorithms in most of these studies are based on structural design models. Such models, although sufficient for preliminary or conceptional design, are not acceptable for detailed design analysis. Careless grid sensitivity evaluations, would introduce gradient errors within the sensitivity module, therefore, infecting the overall optimization process. Development of an efficient and reliable grid sensitivity module with special emphasis on aerodynamic applications appear essential. The organization of this study is as follows. The physical and geometric representations of a typical model are derived in chapter 2. The grid generation algorithm and boundary grid distribution are developed in chapter 3. Chapter 4 discusses the theoretical formulation and aerodynamic sensitivity equation. The method of solution is provided in chapter 5. The results are presented and discussed in chapter 6. Finally, some concluding remarks are provided in chapter 7.

  8. Trends in sensitivity analysis practice in the last decade.

    PubMed

    Ferretti, Federico; Saltelli, Andrea; Tarantola, Stefano

    2016-10-15

    The majority of published sensitivity analyses (SAs) are either local or one factor-at-a-time (OAT) analyses, relying on unjustified assumptions of model linearity and additivity. Global approaches to sensitivity analyses (GSA) which would obviate these shortcomings, are applied by a minority of researchers. By reviewing the academic literature on SA, we here present a bibliometric analysis of the trends of different SA practices in last decade. The review has been conducted both on some top ranking journals (Nature and Science) and through an extended analysis in the Elsevier's Scopus database of scientific publications. After correcting for the global growth in publications, the amount of papers performing a generic SA has notably increased over the last decade. Even if OAT is still the most largely used technique in SA, there is a clear increase in the use of GSA with preference respectively for regression and variance-based techniques. Even after adjusting for the growth of publications in the sole modelling field, to which SA and GSA normally apply, the trend is confirmed. Data about regions of origin and discipline are also briefly discussed. The results above are confirmed when zooming on the sole articles published in chemical modelling, a field historically proficient in the use of SA methods. PMID:26934843

  9. Automated sensitivity analysis using the GRESS language

    SciTech Connect

    Pin, F.G.; Oblow, E.M.; Wright, R.Q.

    1986-04-01

    An automated procedure for performing large-scale sensitivity studies based on the use of computer calculus is presented. The procedure is embodied in a FORTRAN precompiler called GRESS, which automatically processes computer models and adds derivative-taking capabilities to the normal calculated results. In this report, the GRESS code is described, tested against analytic and numerical test problems, and then applied to a major geohydrological modeling problem. The SWENT nuclear waste repository modeling code is used as the basis for these studies. Results for all problems are discussed in detail. Conclusions are drawn as to the applicability of GRESS in the problems at hand and for more general large-scale modeling sensitivity studies.

  10. Sensitivity analysis of Stirling engine design parameters

    SciTech Connect

    Naso, V.; Dong, W.; Lucentini, M.; Capata, R.

    1998-07-01

    In the preliminary Stirling engine design process, the values of some design parameters (temperature ratio, swept volume ratio, phase angle and dead volume ratio) have to be assumed; as a matter of fact it can be difficult to determine the best values of these parameters for a particular engine design. In this paper, a mathematical model is developed to analyze the sensitivity of engine's performance variations corresponding to variations of these parameters.

  11. Discrete analysis of spatial-sensitivity models

    NASA Technical Reports Server (NTRS)

    Nielsen, Kenneth R. K.; Wandell, Brian A.

    1988-01-01

    Procedures for reducing the computational burden of current models of spatial vision are described, the simplifications being consistent with the prediction of the complete model. A method for using pattern-sensitivity measurements to estimate the initial linear transformation is also proposed which is based on the assumption that detection performance is monotonic with the vector length of the sensor responses. It is shown how contrast-threshold data can be used to estimate the linear transformation needed to characterize threshold performance.

  12. Towards More Efficient and Effective Global Sensitivity Analysis

    NASA Astrophysics Data System (ADS)

    Razavi, Saman; Gupta, Hoshin

    2014-05-01

    Sensitivity analysis (SA) is an important paradigm in the context of model development and application. There are a variety of approaches towards sensitivity analysis that formally describe different "intuitive" understandings of the sensitivity of a single or multiple model responses to different factors such as model parameters or forcings. These approaches are based on different philosophies and theoretical definitions of sensitivity and range from simple local derivatives to rigorous Sobol-type analysis-of-variance approaches. In general, different SA methods focus and identify different properties of the model response and may lead to different, sometimes even conflicting conclusions about the underlying sensitivities. This presentation revisits the theoretical basis for sensitivity analysis, critically evaluates the existing approaches in the literature, and demonstrates their shortcomings through simple examples. Important properties of response surfaces that are associated with the understanding and interpretation of sensitivities are outlined. A new approach towards global sensitivity analysis is developed that attempts to encompass the important, sensitivity-related properties of response surfaces. Preliminary results show that the new approach is superior to the standard approaches in the literature in terms of effectiveness and efficiency.

  13. Fuzzy sensitivity analysis for reliability assessment of building structures

    NASA Astrophysics Data System (ADS)

    Kala, Zdeněk

    2016-06-01

    The mathematical concept of fuzzy sensitivity analysis, which studies the effects of the fuzziness of input fuzzy numbers on the fuzziness of the output fuzzy number, is described in the article. The output fuzzy number is evaluated using Zadeh's general extension principle. The contribution of stochastic and fuzzy uncertainty in reliability analysis tasks of building structures is discussed. The algorithm of fuzzy sensitivity analysis is an alternative to stochastic sensitivity analysis in tasks in which input and output variables are considered as fuzzy numbers.

  14. New Uses for Sensitivity Analysis: How Different Movement Tasks Effect Limb Model Parameter Sensitivity

    NASA Technical Reports Server (NTRS)

    Winters, J. M.; Stark, L.

    1984-01-01

    Original results for a newly developed eight-order nonlinear limb antagonistic muscle model of elbow flexion and extension are presented. A wider variety of sensitivity analysis techniques are used and a systematic protocol is established that shows how the different methods can be used efficiently to complement one another for maximum insight into model sensitivity. It is explicitly shown how the sensitivity of output behaviors to model parameters is a function of the controller input sequence, i.e., of the movement task. When the task is changed (for instance, from an input sequence that results in the usual fast movement task to a slower movement that may also involve external loading, etc.) the set of parameters with high sensitivity will in general also change. Such task-specific use of sensitivity analysis techniques identifies the set of parameters most important for a given task, and even suggests task-specific model reduction possibilities.

  15. Global Sensitivity Analysis of Environmental Models: Convergence, Robustness and Validation

    NASA Astrophysics Data System (ADS)

    Sarrazin, Fanny; Pianosi, Francesca; Khorashadi Zadeh, Farkhondeh; Van Griensven, Ann; Wagener, Thorsten

    2015-04-01

    Global Sensitivity Analysis aims to characterize the impact that variations in model input factors (e.g. the parameters) have on the model output (e.g. simulated streamflow). In sampling-based Global Sensitivity Analysis, the sample size has to be chosen carefully in order to obtain reliable sensitivity estimates while spending computational resources efficiently. Furthermore, insensitive parameters are typically identified through the definition of a screening threshold: the theoretical value of their sensitivity index is zero but in a sampling-base framework they regularly take non-zero values. There is little guidance available for these two steps in environmental modelling though. The objective of the present study is to support modellers in making appropriate choices, regarding both sample size and screening threshold, so that a robust sensitivity analysis can be implemented. We performed sensitivity analysis for the parameters of three hydrological models with increasing level of complexity (Hymod, HBV and SWAT), and tested three widely used sensitivity analysis methods (Elementary Effect Test or method of Morris, Regional Sensitivity Analysis, and Variance-Based Sensitivity Analysis). We defined criteria based on a bootstrap approach to assess three different types of convergence: the convergence of the value of the sensitivity indices, of the ranking (the ordering among the parameters) and of the screening (the identification of the insensitive parameters). We investigated the screening threshold through the definition of a validation procedure. The results showed that full convergence of the value of the sensitivity indices is not necessarily needed to rank or to screen the model input factors. Furthermore, typical values of the sample sizes that are reported in the literature can be well below the sample sizes that actually ensure convergence of ranking and screening.

  16. Sensitivity analysis and optimization of thin-film thermoelectric coolers

    NASA Astrophysics Data System (ADS)

    Harsha Choday, Sri; Roy, Kaushik

    2013-06-01

    The cooling performance of a thermoelectric (TE) material is dependent on the figure-of-merit (ZT = S2σT/κ), where S is the Seebeck coefficient, σ and κ are the electrical and thermal conductivities, respectively. The standard definition of ZT assigns equal importance to power factor (S2σ) and thermal conductivity. In this paper, we analyze the relative importance of each thermoelectric parameter on the cooling performance using the mathematical framework of sensitivity analysis. In addition, the impact of the electrical/thermal contact parasitics on bulk and superlattice Bi2Te3 is also investigated. In the presence of significant contact parasitics, we find that the carrier concentration that results in best cooling is lower than that of the highest ZT. We also establish the level of contact parasitics that are needed such that their impact on TE cooling is negligible.

  17. Sensitivity Analysis of a process based erosion model using FAST

    NASA Astrophysics Data System (ADS)

    Gabelmann, Petra; Wienhöfer, Jan; Zehe, Erwin

    2015-04-01

    Erosion, sediment redistribution and related particulate transport are severe problems in agro-ecosystems with highly erodible loess soils. They are controlled by various factors, for example rainfall intensity, topography, initial wetness conditions, spatial patterns of soil hydraulic parameters, land use and tillage practice. The interplay between those factors is not well understood. A number of models were developed to indicate those complex interactions and to estimate the amount of sediment which will be removed, transported and accumulated. In order to make use of physical-based models to provide insight on the physical system under study it is necessary to understand the interactions of parameters and processes in the model domain. Sensitivity analyses give insight in the relative importance of model parameters, which in addition is useful for judging where the greatest efforts have to be spent in acquiring or calibrating input parameters. The objective of this study was to determine the sensitivity of the erosion-related parameters in the CATFLOW model. We analysed simulations from the Weiherbach catchment, where good matches of observed hydrological response and erosion dynamics had been obtained in earlier studies. The Weiherbach catchment is located in an intensively cultivated loess region in southwest Germany and due to the hilly landscape and the highly erodible loess soils, erosion is a severe environmental problem. CATFLOW is a process-based hydrology and erosion model that can operate on catchment and hillslope scales. Soil water dynamics are described by the Richards equation including effective approaches for preferential flow. Evapotranspiration is simulated using an approach based on the Penman-Monteith equation. The model simulates overland flow using the diffusion wave equation. Soil detachment is related to the attacking forces of rainfall and overland flow, and the erosion resistance of the soil. Sediment transport capacity and sediment

  18. Accelerated Sensitivity Analysis in High-Dimensional Stochastic Reaction Networks

    PubMed Central

    Arampatzis, Georgios; Katsoulakis, Markos A.; Pantazis, Yannis

    2015-01-01

    Existing sensitivity analysis approaches are not able to handle efficiently stochastic reaction networks with a large number of parameters and species, which are typical in the modeling and simulation of complex biochemical phenomena. In this paper, a two-step strategy for parametric sensitivity analysis for such systems is proposed, exploiting advantages and synergies between two recently proposed sensitivity analysis methodologies for stochastic dynamics. The first method performs sensitivity analysis of the stochastic dynamics by means of the Fisher Information Matrix on the underlying distribution of the trajectories; the second method is a reduced-variance, finite-difference, gradient-type sensitivity approach relying on stochastic coupling techniques for variance reduction. Here we demonstrate that these two methods can be combined and deployed together by means of a new sensitivity bound which incorporates the variance of the quantity of interest as well as the Fisher Information Matrix estimated from the first method. The first step of the proposed strategy labels sensitivities using the bound and screens out the insensitive parameters in a controlled manner. In the second step of the proposed strategy, a finite-difference method is applied only for the sensitivity estimation of the (potentially) sensitive parameters that have not been screened out in the first step. Results on an epidermal growth factor network with fifty parameters and on a protein homeostasis with eighty parameters demonstrate that the proposed strategy is able to quickly discover and discard the insensitive parameters and in the remaining potentially sensitive parameters it accurately estimates the sensitivities. The new sensitivity strategy can be several times faster than current state-of-the-art approaches that test all parameters, especially in “sloppy” systems. In particular, the computational acceleration is quantified by the ratio between the total number of parameters over

  19. Sensitivity analysis for aeroacoustic and aeroelastic design of turbomachinery blades

    NASA Technical Reports Server (NTRS)

    Lorence, Christopher B.; Hall, Kenneth C.

    1995-01-01

    A new method for computing the effect that small changes in the airfoil shape and cascade geometry have on the aeroacoustic and aeroelastic behavior of turbomachinery cascades is presented. The nonlinear unsteady flow is assumed to be composed of a nonlinear steady flow plus a small perturbation unsteady flow that is harmonic in time. First, the full potential equation is used to describe the behavior of the nonlinear mean (steady) flow through a two-dimensional cascade. The small disturbance unsteady flow through the cascade is described by the linearized Euler equations. Using rapid distortion theory, the unsteady velocity is split into a rotational part that contains the vorticity and an irrotational part described by a scalar potential. The unsteady vorticity transport is described analytically in terms of the drift and stream functions computed from the steady flow. Hence, the solution of the linearized Euler equations may be reduced to a single inhomogeneous equation for the unsteady potential. The steady flow and small disturbance unsteady flow equations are discretized using bilinear quadrilateral isoparametric finite elements. The nonlinear mean flow solution and streamline computational grid are computed simultaneously using Newton iteration. At each step of the Newton iteration, LU decomposition is used to solve the resulting set of linear equations. The unsteady flow problem is linear, and is also solved using LU decomposition. Next, a sensitivity analysis is performed to determine the effect small changes in cascade and airfoil geometry have on the mean and unsteady flow fields. The sensitivity analysis makes use of the nominal steady and unsteady flow LU decompositions so that no additional matrices need to be factored. Hence, the present method is computationally very efficient. To demonstrate how the sensitivity analysis may be used to redesign cascades, a compressor is redesigned for improved aeroelastic stability and two different fan exit guide

  20. Modifying structure-sensitive reactions by addition of Zn to Pd

    SciTech Connect

    Childers, David J.; Schweitzer, Neil M.; Kamali Shahari, Seyed Mehdi; Rioux, Robert M.; Miller, Jeffrey T.; Meyer, Randall J.

    2014-10-01

    Silica-supported Pd and PdZn nanoparticles of a similar size were evaluated for neopentane hydrogenolysis/isomerization and propane hydrogenolysis/dehydrogenation. Monometallic Pd showed high neopentane hydrogenolysis selectivity. Addition of small amounts of Zn to Pd lead Pd–Zn scatters in the EXAFS spectrum and an increase in the linear bonded CO by IR. In addition, the neopentane turnover rate decreased by nearly 10 times with little change in the selectivity. Increasing amounts of Zn lead to greater Pd–Zn interactions, higher linear-to-bridging CO ratios by IR and complete loss of neopentane conversion. Pd NPs also had high selectivity for propane hydrogenolysis and thus were poorly selective for propylene. The PdZn bimetallic catalysts, however, were able to preferentially catalyze dehydrogenation, were not active for propane hydrogenolysis, and thus were highly selective for propylene formation. The decrease in hydrogenolysis selectivity was attributed to the isolation of active Pd atoms by inactive metallic Zn,demonstrating that hydrogenolysis requires a particular reactive ensemble whereas propane dehydrogenation does not.

  1. Boundary formulations for sensitivity analysis without matrix derivatives

    NASA Technical Reports Server (NTRS)

    Kane, J. H.; Guru Prasad, K.

    1993-01-01

    A new hybrid approach to continuum structural shape sensitivity analysis employing boundary element analysis (BEA) is presented. The approach uses iterative reanalysis to obviate the need to factor perturbed matrices in the determination of surface displacement and traction sensitivities via a univariate perturbation/finite difference (UPFD) step. The UPFD approach makes it possible to immediately reuse existing subroutines for computation of BEA matrix coefficients in the design sensitivity analysis process. The reanalysis technique computes economical response of univariately perturbed models without factoring perturbed matrices. The approach provides substantial computational economy without the burden of a large-scale reprogramming effort.

  2. Sensitivity of Arctic Permafrost Carbon in the Mackenzie River Basin: A substrate addition and incubation experiment

    NASA Astrophysics Data System (ADS)

    Hedgpeth, A.; Beilman, D.; Crow, S. E.

    2014-12-01

    Arctic soil organic matter (SOM) mineralization processes are fundamental to the functioning of high latitude soils in relation to nutrients, stability, and feedbacks to atmospheric CO2 and climate. The arctic permafrost zone covers 25% of the northern hemisphere and contains 1672Pg of soil carbon (C). 88% of this C currently resides in frozen soils that are vulnerable to environmental change. For instance, arctic growing seasons may be lengthened, resulting in an increase in plant productivity and rate of below ground labile C inputs as root exudates. Understanding controls on Arctic SOM dynamics requires recognition that labile C inputs have the potential to significantly affect mineralization of previously stable SOM, also known as 'priming effects'. We conducted a substrate addition incubation experiment to quantify and compare respiration in highly organic (42-48 %C) permafrost soils along a north-south transect in western Canada. Near surface soils (10-20 cm) were collected from permafrost peatland sites in the Mackenzie River Basin from 69.2-62.6°N. The surface soils are fairly young (Δ14C values > -140.0) and can be assumed to contain relatively reactive soil carbon. To assess whether addition of labile substrate alters SOM decomposition dynamics, 4.77-11.75 g of permafrost soil were spiked with 0.5 mg D-glucose g-1 soil and incubated at 5°C. A mass balance approach was used to determin substrate-induced respiration and preliminary results suggest a potential for positive priming in these C-rich soils. Baseline respiration rates from the three sites were similar (0.067-0.263 mg CO2 g-1 soil C) yet show some site-specific trends. The rate at which added substrate was utilized within these soils suggests that other factors besides temperature and soil C content are controlling substrate consumption and its effect on SOM decomposition. Microbial activity can be stimulated by substrate addition to such an extent that SOM turnover is enhanced, suggesting that

  3. Partial Differential Algebraic Sensitivity Analysis Code

    1995-05-15

    PDASAC solves stiff, nonlinear initial-boundary-value in a timelike dimension t and a space dimension x. Plane, circular cylindrical or spherical boundaries can be handled. Mixed-order systems of partial differential and algebraic equations can be analyzed with members of order or 0 or 1 in t, 0,1 or 2 in x. Parametric sensitivities of the calculated states are compted simultaneously on request, via the Jacobian of the state equations. Initial and boundary conditions are efficiently reconciled.more » Local error control (in the max-norm or the 2-norm) is provided for the state vector and can include the parametric sensitivites if desired.« less

  4. Aero-Structural Interaction, Analysis, and Shape Sensitivity

    NASA Technical Reports Server (NTRS)

    Newman, James C., III

    1999-01-01

    A multidisciplinary sensitivity analysis technique that has been shown to be independent of step-size selection is examined further. The accuracy of this step-size independent technique, which uses complex variables for determining sensitivity derivatives, has been previously established. The primary focus of this work is to validate the aero-structural analysis procedure currently being used. This validation consists of comparing computed and experimental data obtained for an Aeroelastic Research Wing (ARW-2). Since the aero-structural analysis procedure has the complex variable modifications already included into the software, sensitivity derivatives can automatically be computed. Other than for design purposes, sensitivity derivatives can be used for predicting the solution at nearby conditions. The use of sensitivity derivatives for predicting the aero-structural characteristics of this configuration is demonstrated.

  5. Automating sensitivity analysis of computer models using computer calculus

    SciTech Connect

    Oblow, E.M.; Pin, F.G.

    1985-01-01

    An automated procedure for performing sensitivity analyses has been developed. The procedure uses a new FORTRAN compiler with computer calculus capabilities to generate the derivatives needed to set up sensitivity equations. The new compiler is called GRESS - Gradient Enhanced Software System. Application of the automated procedure with ''direct'' and ''adjoint'' sensitivity theory for the analysis of non-linear, iterative systems of equations is discussed. Calculational efficiency consideration and techniques for adjoint sensitivity analysis are emphasized. The new approach is found to preserve the traditional advantages of adjoint theory while removing the tedious human effort previously needed to apply this theoretical methodology. Conclusions are drawn about the applicability of the automated procedure in numerical analysis and large-scale modelling sensitivity studies. 24 refs., 2 figs.

  6. Automated procedure for sensitivity analysis using computer calculus

    SciTech Connect

    Oblow, E.M.

    1983-05-01

    An automated procedure for performing sensitivity analyses has been developed. The procedure uses a new FORTRAN compiler with computer calculus capabilities to generate the derivatives needed to set up sensitivity equations. The new compiler is called GRESS - Gradient Enhanced Software System. Application of the automated procedure with direct and adjoint sensitivity theory for the analysis of non-linear, iterative systems of equations is discussed. Calculational efficiency consideration and techniques for adjoint sensitivity analysis are emphasized. The new approach was found to preserve the traditional advantages of adjoint theory while removing the tedious human effort previously needed to apply this theoretical methodology. Conclusions are drawn about the applicability of the automated procedure in numerical analysis and large-scale modelling sensitivity studies.

  7. Ensemble Solar Forecasting Statistical Quantification and Sensitivity Analysis: Preprint

    SciTech Connect

    Cheung, WanYin; Zhang, Jie; Florita, Anthony; Hodge, Bri-Mathias; Lu, Siyuan; Hamann, Hendrik F.; Sun, Qian; Lehman, Brad

    2015-12-08

    Uncertainties associated with solar forecasts present challenges to maintain grid reliability, especially at high solar penetrations. This study aims to quantify the errors associated with the day-ahead solar forecast parameters and the theoretical solar power output for a 51-kW solar power plant in a utility area in the state of Vermont, U.S. Forecasts were generated by three numerical weather prediction (NWP) models, including the Rapid Refresh, the High Resolution Rapid Refresh, and the North American Model, and a machine-learning ensemble model. A photovoltaic (PV) performance model was adopted to calculate theoretical solar power generation using the forecast parameters (e.g., irradiance, cell temperature, and wind speed). Errors of the power outputs were quantified using statistical moments and a suite of metrics, such as the normalized root mean squared error (NRMSE). In addition, the PV model's sensitivity to different forecast parameters was quantified and analyzed. Results showed that the ensemble model yielded forecasts in all parameters with the smallest NRMSE. The NRMSE of solar irradiance forecasts of the ensemble NWP model was reduced by 28.10% compared to the best of the three NWP models. Further, the sensitivity analysis indicated that the errors of the forecasted cell temperature attributed only approximately 0.12% to the NRMSE of the power output as opposed to 7.44% from the forecasted solar irradiance.

  8. A topological approach to computer-aided sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Chan, S. P.; Munoz, R. M.

    1971-01-01

    Sensitivities of any arbitrary system are calculated using general purpose digital computer with available software packages for transfer function analysis. Sensitivity shows how element variation within system affects system performance. Signal flow graph illustrates topological system behavior and relationship among parameters in system.

  9. Global and Local Sensitivity Analysis Methods for a Physical System

    ERIC Educational Resources Information Center

    Morio, Jerome

    2011-01-01

    Sensitivity analysis is the study of how the different input variations of a mathematical model influence the variability of its output. In this paper, we review the principle of global and local sensitivity analyses of a complex black-box system. A simulated case of application is given at the end of this paper to compare both approaches.…

  10. Advanced Fuel Cycle Economic Sensitivity Analysis

    SciTech Connect

    David Shropshire; Kent Williams; J.D. Smith; Brent Boore

    2006-12-01

    A fuel cycle economic analysis was performed on four fuel cycles to provide a baseline for initial cost comparison using the Gen IV Economic Modeling Work Group G4 ECON spreadsheet model, Decision Programming Language software, the 2006 Advanced Fuel Cycle Cost Basis report, industry cost data, international papers, the nuclear power related cost study from MIT, Harvard, and the University of Chicago. The analysis developed and compared the fuel cycle cost component of the total cost of energy for a wide range of fuel cycles including: once through, thermal with fast recycle, continuous fast recycle, and thermal recycle.

  11. Sensitivity Analysis in Complex Plasma Chemistry Models

    NASA Astrophysics Data System (ADS)

    Turner, Miles

    2015-09-01

    The purpose of a plasma chemistry model is prediction of chemical species densities, including understanding the mechanisms by which such species are formed. These aims are compromised by an uncertain knowledge of the rate constants included in the model, which directly causes uncertainty in the model predictions. We recently showed that this predictive uncertainty can be large--a factor of ten or more in some cases. There is probably no context in which a plasma chemistry model might be used where the existence of uncertainty on this scale could not be a matter of concern. A question that at once follows is: Which rate constants cause such uncertainty? In the present paper we show how this question can be answered by applying a systematic screening procedure--the so-called Morris method--to identify sensitive rate constants. We investigate the topical example of the helium-oxygen chemistry. Beginning with a model with almost four hundred reactions, we show that only about fifty rate constants materially affect the model results, and as few as ten cause most of the uncertainty. This means that the model can be improved, and the uncertainty substantially reduced, by focussing attention on this tractably small set of rate constants. Work supported by Science Foundation Ireland under grant08/SRC/I1411, and by COST Action MP1101 ``Biomedical Applications of Atmospheric Pressure Plasmas.''

  12. Selecting step sizes in sensitivity analysis by finite differences

    NASA Technical Reports Server (NTRS)

    Iott, J.; Haftka, R. T.; Adelman, H. M.

    1985-01-01

    This paper deals with methods for obtaining near-optimum step sizes for finite difference approximations to first derivatives with particular application to sensitivity analysis. A technique denoted the finite difference (FD) algorithm, previously described in the literature and applicable to one derivative at a time, is extended to the calculation of several simultaneously. Both the original and extended FD algorithms are applied to sensitivity analysis for a data-fitting problem in which derivatives of the coefficients of an interpolation polynomial are calculated with respect to uncertainties in the data. The methods are also applied to sensitivity analysis of the structural response of a finite-element-modeled swept wing. In a previous study, this sensitivity analysis of the swept wing required a time-consuming trial-and-error effort to obtain a suitable step size, but it proved to be a routine application for the extended FD algorithm herein.

  13. Parameter sensitivity analysis for pesticide impacts on honeybee colonies

    EPA Science Inventory

    We employ Monte Carlo simulation and linear sensitivity analysis techniques to describe the dynamics of a bee exposure model, VarroaPop. Daily simulations are performed that simulate hive population trajectories, taking into account queen strength, foraging success, weather, colo...

  14. SYSTEMATIC SENSITIVITY ANALYSIS OF AIR QUALITY SIMULATION MODELS

    EPA Science Inventory

    This report reviews and assesses systematic sensitivity and uncertainty analysis methods for applications to air quality simulation models. The discussion of the candidate methods presents their basic variables, mathematical foundations, user motivations and preferences, computer...

  15. On the sensitivity analysis of porous material models

    NASA Astrophysics Data System (ADS)

    Ouisse, Morvan; Ichchou, Mohamed; Chedly, Slaheddine; Collet, Manuel

    2012-11-01

    Porous materials are used in many vibroacoustic applications. Different available models describe their behaviors according to materials' intrinsic characteristics. For instance, in the case of porous material with rigid frame, and according to the Champoux-Allard model, five parameters are employed. In this paper, an investigation about this model sensitivity to parameters according to frequency is conducted. Sobol and FAST algorithms are used for sensitivity analysis. A strong parametric frequency dependent hierarchy is shown. Sensitivity investigations confirm that resistivity is the most influent parameter when acoustic absorption and surface impedance of porous materials with rigid frame are considered. The analysis is first performed on a wide category of porous materials, and then restricted to a polyurethane foam analysis in order to illustrate the impact of the reduction of the design space. In a second part, a sensitivity analysis is performed using the Biot-Allard model with nine parameters including mechanical effects of the frame and conclusions are drawn through numerical simulations.

  16. Nonparametric survival analysis using Bayesian Additive Regression Trees (BART).

    PubMed

    Sparapani, Rodney A; Logan, Brent R; McCulloch, Robert E; Laud, Purushottam W

    2016-07-20

    Bayesian additive regression trees (BART) provide a framework for flexible nonparametric modeling of relationships of covariates to outcomes. Recently, BART models have been shown to provide excellent predictive performance, for both continuous and binary outcomes, and exceeding that of its competitors. Software is also readily available for such outcomes. In this article, we introduce modeling that extends the usefulness of BART in medical applications by addressing needs arising in survival analysis. Simulation studies of one-sample and two-sample scenarios, in comparison with long-standing traditional methods, establish face validity of the new approach. We then demonstrate the model's ability to accommodate data from complex regression models with a simulation study of a nonproportional hazards scenario with crossing survival functions and survival function estimation in a scenario where hazards are multiplicatively modified by a highly nonlinear function of the covariates. Using data from a recently published study of patients undergoing hematopoietic stem cell transplantation, we illustrate the use and some advantages of the proposed method in medical investigations. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26854022

  17. Sensitivity Analysis of the Gap Heat Transfer Model in BISON.

    SciTech Connect

    Swiler, Laura Painton; Schmidt, Rodney C.; Williamson, Richard; Perez, Danielle

    2014-10-01

    This report summarizes the result of a NEAMS project focused on sensitivity analysis of the heat transfer model in the gap between the fuel rod and the cladding used in the BISON fuel performance code of Idaho National Laboratory. Using the gap heat transfer models in BISON, the sensitivity of the modeling parameters and the associated responses is investigated. The study results in a quantitative assessment of the role of various parameters in the analysis of gap heat transfer in nuclear fuel.

  18. Sensitization to Food Additives in Patients with Allergy: A Study Based on Skin Test and Open Oral Challenge.

    PubMed

    Moghtaderi, Mozhgan; Hejrati, Zinatosadat; Dehghani, Zahra; Dehghani, Faranak; Kolahi, Niloofar

    2016-06-01

    There has been a great increase in the consumption of various food additives in recent years. The purpose of this study was to identify the incidence of sensitization to food additives by using skin prick test in patients with allergy and to determine the concordance rate between positive skin tests and oral challenge in hypersensitivity to additives. This cross-sectional study included 125 (female 71, male 54) patients aged 2-76 years with allergy and 100 healthy individuals. Skin tests were performed in both patient and control groups with 25 fresh food additives. Among patients with allergy, 22.4% showed positive skin test at least to one of the applied materials. Skin test was negative to all tested food additives in control group. Oral food challenge was done in 28 patients with positive skin test, in whom 9 patients showed reaction to culprit (Concordance rate=32.1%). The present study suggested that about one-third of allergic patients with positive reaction to food additives showed positive oral challenge; it may be considered the potential utility of skin test to identify the role of food additives in patients with allergy. PMID:27424134

  19. Enhanced photovoltaic properties of modified redox electrolyte in dye-sensitized solar cells using tributyl phosphate as additive

    NASA Astrophysics Data System (ADS)

    Afrooz, Malihe; Dehghani, Hossein

    2014-09-01

    In this study, we report the influence of a phosphate additive on the performance of dye-sensitized solar cells (DSSCs) based on 2-cyano-3-(4-(diphenylamino)phenyl)acrylic acid (TPA) as sensitizer. The DSSCs are fabricated by incorporating tributyl phosphate (TBPP) as an additive in the electrolyte and is attained an efficiency of about 3.03% under standard air mass 1.5 global (AM 1.5G) simulated sunlight, corresponding to 35% efficiency increment compare to the standard liquid electrolyte. An improvement in both open circuit voltage (Voc) and short circuit current (Jsc) obtains by adjusting the concentration of TBPP in the electrolyte, which attributes to enlarge energy difference between the Fermi level (EF) of TiO2 and the redox potential of electrolyte and suppression of charge recombination from the conduction band (CB) of TiO2 to the oxidized ions in the redox electrolyte. Electrochemical impedance analyses (EIS) reveals a dramatic increase in charge transfer resistance at the dyed-TiO2/electrolyte interface and the electron density in the CB of TiO2 that the more prominent photoelectric conversion efficiency (η) improvement with TBPP additive results by the efficient inhibition of recombination processes. This striking result leads to use a family of electron donor groups in many compounds as highly efficient additive.

  20. Fixed point sensitivity analysis of interacting structured populations.

    PubMed

    Barabás, György; Meszéna, Géza; Ostling, Annette

    2014-03-01

    Sensitivity analysis of structured populations is a useful tool in population ecology. Historically, methodological development of sensitivity analysis has focused on the sensitivity of eigenvalues in linear matrix models, and on single populations. More recently there have been extensions to the sensitivity of nonlinear models, and to communities of interacting populations. Here we derive a fully general mathematical expression for the sensitivity of equilibrium abundances in communities of interacting structured populations. Our method yields the response of an arbitrary function of the stage class abundances to perturbations of any model parameters. As a demonstration, we apply this sensitivity analysis to a two-species model of ontogenetic niche shift where each species has two stage classes, juveniles and adults. In the context of this model, we demonstrate that our theory is quite robust to violating two of its technical assumptions: the assumption that the community is at a point equilibrium and the assumption of infinitesimally small parameter perturbations. Our results on the sensitivity of a community are also interpreted in a niche theoretical context: we determine how the niche of a structured population is composed of the niches of the individual states, and how the sensitivity of the community depends on niche segregation. PMID:24368160

  1. Advancing sensitivity analysis to precisely characterize temporal parameter dominance

    NASA Astrophysics Data System (ADS)

    Guse, Björn; Pfannerstill, Matthias; Strauch, Michael; Reusser, Dominik; Lüdtke, Stefan; Volk, Martin; Gupta, Hoshin; Fohrer, Nicola

    2016-04-01

    Parameter sensitivity analysis is a strategy for detecting dominant model parameters. A temporal sensitivity analysis calculates daily sensitivities of model parameters. This allows a precise characterization of temporal patterns of parameter dominance and an identification of the related discharge conditions. To achieve this goal, the diagnostic information as derived from the temporal parameter sensitivity is advanced by including discharge information in three steps. In a first step, the temporal dynamics are analyzed by means of daily time series of parameter sensitivities. As sensitivity analysis method, we used the Fourier Amplitude Sensitivity Test (FAST) applied directly onto the modelled discharge. Next, the daily sensitivities are analyzed in combination with the flow duration curve (FDC). Through this step, we determine whether high sensitivities of model parameters are related to specific discharges. Finally, parameter sensitivities are separately analyzed for five segments of the FDC and presented as monthly averaged sensitivities. In this way, seasonal patterns of dominant model parameter are provided for each FDC segment. For this methodical approach, we used two contrasting catchments (upland and lowland catchment) to illustrate how parameter dominances change seasonally in different catchments. For all of the FDC segments, the groundwater parameters are dominant in the lowland catchment, while in the upland catchment the controlling parameters change seasonally between parameters from different runoff components. The three methodical steps lead to clear temporal patterns, which represent the typical characteristics of the study catchments. Our methodical approach thus provides a clear idea of how the hydrological dynamics are controlled by model parameters for certain discharge magnitudes during the year. Overall, these three methodical steps precisely characterize model parameters and improve the understanding of process dynamics in hydrological

  2. A near-infrared spectroscopic study of young field ultracool dwarfs: additional analysis

    NASA Astrophysics Data System (ADS)

    Allers, K. N.; Liu, M. C.

    We present additional analysis of the classification system presented in \\citet{allers13}. We refer the reader to \\citet{allers13} for a detailed discussion of our near-IR spectral type and gravity classification system. Here, we address questions and comments from participants of the Brown Dwarfs Come of Age meeting. In particular, we examine the effects of binarity and metallicity on our classification system. We also present our classification of Pleiades brown dwarfs using published spectra. Lastly, we determine SpTs and calculate gravity-sensitive indices for the BT-Settl atmospheric models and compare them to observations.

  3. Precessing rotating flows with additional shear: Stability analysis

    NASA Astrophysics Data System (ADS)

    Salhi, A.; Cambon, C.

    2009-03-01

    We consider unbounded precessing rotating flows in which vertical or horizontal shear is induced by the interaction between the solid-body rotation (with angular velocity Ω0 ) and the additional “precessing” Coriolis force (with angular velocity -ɛΩ0 ), normal to it. A “weak” shear flow, with rate 2ɛ of the same order of the Poincaré “small” ratio ɛ , is needed for balancing the gyroscopic torque, so that the whole flow satisfies Euler’s equations in the precessing frame (the so-called admissibility conditions). The base flow case with vertical shear (its cross-gradient direction is aligned with the main angular velocity) corresponds to Mahalov’s [Phys. Fluids A 5, 891 (1993)] precessing infinite cylinder base flow (ignoring boundary conditions), while the base flow case with horizontal shear (its cross-gradient direction is normal to both main and precessing angular velocities) corresponds to the unbounded precessing rotating shear flow considered by Kerswell [Geophys. Astrophys. Fluid Dyn. 72, 107 (1993)]. We show that both these base flows satisfy the admissibility conditions and can support disturbances in terms of advected Fourier modes. Because the admissibility conditions cannot select one case with respect to the other, a more physical derivation is sought: Both flows are deduced from Poincaré’s [Bull. Astron. 27, 321 (1910)] basic state of a precessing spheroidal container, in the limit of small ɛ . A Rapid distortion theory (RDT) type of stability analysis is then performed for the previously mentioned disturbances, for both base flows. The stability analysis of the Kerswell base flow, using Floquet’s theory, is recovered, and its counterpart for the Mahalov base flow is presented. Typical growth rates are found to be the same for both flows at very small ɛ , but significant differences are obtained regarding growth rates and widths of instability bands, if larger ɛ values, up to 0.2, are considered. Finally, both flow cases

  4. Seismoelectric beamforming imaging: a sensitivity analysis

    NASA Astrophysics Data System (ADS)

    El Khoury, P.; Revil, A.; Sava, P.

    2015-06-01

    The electrical current density generated by the propagation of a seismic wave at the interface characterized by a drop in electrical, hydraulic or mechanical properties produces an electrical field of electrokinetic nature. This field can be measured remotely with a signal-to-noise ratio depending on the background noise and signal attenuation. The seismoelectric beamforming approach is an emerging imaging technique based on scanning a porous material using appropriately delayed seismic sources. The idea is to focus the hydromechanical energy on a regular spatial grid and measure the converted electric field remotely at each focus time. This method can be used to image heterogeneities with a high definition and to provide structural information to classical geophysical methods. A numerical experiment is performed to investigate the resolution of the seismoelectric beamforming approach with respect to the main wavelength of the seismic waves. The 2-D model consists of a fictitious water-filled bucket in which a cylindrical sandstone core sample is set up vertically. The hydrophones/seismic sources are located on a 50-cm diameter circle in the bucket and the seismic energy is focused on the grid points in order to scan the medium and determine the geometry of the porous plug using the output electric potential image. We observe that the resolution of the method is given by a density of eight scanning points per wavelength. Additional numerical tests were also performed to see the impact of a wrong velocity model upon the seismoelectric map displaying the heterogeneities of the material.

  5. Design sensitivity analysis using EAL. Part 1: Conventional design parameters

    NASA Technical Reports Server (NTRS)

    Dopker, B.; Choi, Kyung K.; Lee, J.

    1986-01-01

    A numerical implementation of design sensitivity analysis of builtup structures is presented, using the versatility and convenience of an existing finite element structural analysis code and its database management system. The finite element code used in the implemenatation presented is the Engineering Analysis Language (EAL), which is based on a hybrid method of analysis. It was shown that design sensitivity computations can be carried out using the database management system of EAL, without writing a separate program and a separate database. Conventional (sizing) design parameters such as cross-sectional area of beams or thickness of plates and plane elastic solid components are considered. Compliance, displacement, and stress functionals are considered as performance criteria. The method presented is being extended to implement shape design sensitivity analysis using a domain method and a design component method.

  6. Influence of Si Addition on Quenching Sensitivity and Formation of Nano-Precipitate in Al-Mg-Si Alloys.

    PubMed

    Kim, JaeHwang; Hayashi, Minoru; Kobayashi, Equo; Sato, Tatsuo

    2016-02-01

    The age-hardening is enhanced with the high cooling rate since more vacancies are formed during quenching, whereas the stable beta phase is formed with the slow cooling rate just after solid solution treatment resulting in lower increase of hardness during aging. Meanwhile, the nanoclusters are formed during natural aging in Al-Mg-Si alloys. The formation of nanoclusters is enhanced with increasing the Si amount. High quench sensitivity based on mechanical property changes was confirmed with increasing the Si amount. Moreover, the nano-size beta" phase, main hardening phase, is more formed by the Si addition resulting in enhancement of the age-hardening. The quench sensitivity and the formation behavior of precipitates are discussed based on the age-hardening phenomena. PMID:27433677

  7. Variational Methods in Sensitivity Analysis and Optimization for Aerodynamic Applications

    NASA Technical Reports Server (NTRS)

    Ibrahim, A. H.; Hou, G. J.-W.; Tiwari, S. N. (Principal Investigator)

    1996-01-01

    Variational methods (VM) sensitivity analysis, which is the continuous alternative to the discrete sensitivity analysis, is employed to derive the costate (adjoint) equations, the transversality conditions, and the functional sensitivity derivatives. In the derivation of the sensitivity equations, the variational methods use the generalized calculus of variations, in which the variable boundary is considered as the design function. The converged solution of the state equations together with the converged solution of the costate equations are integrated along the domain boundary to uniquely determine the functional sensitivity derivatives with respect to the design function. The determination of the sensitivity derivatives of the performance index or functional entails the coupled solutions of the state and costate equations. As the stable and converged numerical solution of the costate equations with their boundary conditions are a priori unknown, numerical stability analysis is performed on both the state and costate equations. Thereafter, based on the amplification factors obtained by solving the generalized eigenvalue equations, the stability behavior of the costate equations is discussed and compared with the state (Euler) equations. The stability analysis of the costate equations suggests that the converged and stable solution of the costate equation is possible only if the computational domain of the costate equations is transformed to take into account the reverse flow nature of the costate equations. The application of the variational methods to aerodynamic shape optimization problems is demonstrated for internal flow problems at supersonic Mach number range. The study shows, that while maintaining the accuracy of the functional sensitivity derivatives within the reasonable range for engineering prediction purposes, the variational methods show a substantial gain in computational efficiency, i.e., computer time and memory, when compared with the finite

  8. Aeroacoustic sensitivity analysis and optimal aeroacoustic design of turbomachinery blades

    NASA Technical Reports Server (NTRS)

    Hall, Kenneth C.

    1994-01-01

    During the first year of the project, we have developed a theoretical analysis - and wrote a computer code based on this analysis - to compute the sensitivity of unsteady aerodynamic loads acting on airfoils in cascades due to small changes in airfoil geometry. The steady and unsteady flow though a cascade of airfoils is computed using the full potential equation. Once the nominal solutions have been computed, one computes the sensitivity. The analysis takes advantage of the fact that LU decomposition is used to compute the nominal steady and unsteady flow fields. If the LU factors are saved, then the computer time required to compute the sensitivity of both the steady and unsteady flows to changes in airfoil geometry is quite small. The results to date are quite encouraging, and may be summarized as follows: (1) The sensitivity procedure has been validated by comparing the results obtained by 'finite difference' techniques, that is, computing the flow using the nominal flow solver for two slightly different airfoils and differencing the results. The 'analytic' solution computed using the method developed under this grant and the finite difference results are found to be in almost perfect agreement. (2) The present sensitivity analysis is computationally much more efficient than finite difference techniques. We found that using a 129 by 33 node computational grid, the present sensitivity analysis can compute the steady flow sensitivity about ten times more efficiently that the finite difference approach. For the unsteady flow problem, the present sensitivity analysis is about two and one-half times as fast as the finite difference approach. We expect that the relative efficiencies will be even larger for the finer grids which will be used to compute high frequency aeroacoustic solutions. Computational results show that the sensitivity analysis is valid for small to moderate sized design perturbations. (3) We found that the sensitivity analysis provided important

  9. Sensitivity Analysis of the Integrated Medical Model for ISS Programs

    NASA Technical Reports Server (NTRS)

    Goodenow, D. A.; Myers, J. G.; Arellano, J.; Boley, L.; Garcia, Y.; Saile, L.; Walton, M.; Kerstman, E.; Reyes, D.; Young, M.

    2016-01-01

    Sensitivity analysis estimates the relative contribution of the uncertainty in input values to the uncertainty of model outputs. Partial Rank Correlation Coefficient (PRCC) and Standardized Rank Regression Coefficient (SRRC) are methods of conducting sensitivity analysis on nonlinear simulation models like the Integrated Medical Model (IMM). The PRCC method estimates the sensitivity using partial correlation of the ranks of the generated input values to each generated output value. The partial part is so named because adjustments are made for the linear effects of all the other input values in the calculation of correlation between a particular input and each output. In SRRC, standardized regression-based coefficients measure the sensitivity of each input, adjusted for all the other inputs, on each output. Because the relative ranking of each of the inputs and outputs is used, as opposed to the values themselves, both methods accommodate the nonlinear relationship of the underlying model. As part of the IMM v4.0 validation study, simulations are available that predict 33 person-missions on ISS and 111 person-missions on STS. These simulated data predictions feed the sensitivity analysis procedures. The inputs to the sensitivity procedures include the number occurrences of each of the one hundred IMM medical conditions generated over the simulations and the associated IMM outputs: total quality time lost (QTL), number of evacuations (EVAC), and number of loss of crew lives (LOCL). The IMM team will report the results of using PRCC and SRRC on IMM v4.0 predictions of the ISS and STS missions created as part of the external validation study. Tornado plots will assist in the visualization of the condition-related input sensitivities to each of the main outcomes. The outcomes of this sensitivity analysis will drive review focus by identifying conditions where changes in uncertainty could drive changes in overall model output uncertainty. These efforts are an integral

  10. Sensitivity analysis of TOPSIS method in water quality assessment: I. Sensitivity to the parameter weights.

    PubMed

    Li, Peiyue; Qian, Hui; Wu, Jianhua; Chen, Jie

    2013-03-01

    Sensitivity analysis is becoming increasingly widespread in many fields of engineering and sciences and has become a necessary step to verify the feasibility and reliability of a model or a method. The sensitivity of the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method in water quality assessment mainly includes sensitivity to the parameter weights and sensitivity to the index input data. In the present study, the sensitivity of TOPSIS to the parameter weights was discussed in detail. The present study assumed the original parameter weights to be equal to each other, and then each weight was changed separately to see how the assessment results would be affected. Fourteen schemes were designed to investigate the sensitivity to the variation of each weight. The variation ranges that keep the assessment results unchangeable were also derived theoretically. The results show that the final assessment results will change when the weights increase or decrease by ±20 to ±50 %. The feedback of different samples to the variation of a given weight is different, and the feedback of a given sample to the variation of different weights is also different. The final assessment results can keep relatively stable when a given weight is disturbed as long as the initial variation ratios meet one of the eight derived requirements. PMID:22752962

  11. Sensitivity analysis technique for application to deterministic models

    SciTech Connect

    Ishigami, T.; Cazzoli, E.; Khatib-Rahbar, M.; Unwin, S.D.

    1987-01-01

    The characterization of sever accident source terms for light water reactors should include consideration of uncertainties. An important element of any uncertainty analysis is an evaluation of the sensitivity of the output probability distributions reflecting source term uncertainties to assumptions regarding the input probability distributions. Historically, response surface methods (RSMs) were developed to replace physical models using, for example, regression techniques, with simplified models for example, regression techniques, with simplified models for extensive calculations. The purpose of this paper is to present a new method for sensitivity analysis that does not utilize RSM, but instead relies directly on the results obtained from the original computer code calculations. The merits of this approach are demonstrated by application of the proposed method to the suppression pool aerosol removal code (SPARC), and the results are compared with those obtained by sensitivity analysis with (a) the code itself, (b) a regression model, and (c) Iman's method.

  12. Sensitivity analysis for missing data in regulatory submissions.

    PubMed

    Permutt, Thomas

    2016-07-30

    The National Research Council Panel on Handling Missing Data in Clinical Trials recommended that sensitivity analyses have to be part of the primary reporting of findings from clinical trials. Their specific recommendations, however, seem not to have been taken up rapidly by sponsors of regulatory submissions. The NRC report's detailed suggestions are along rather different lines than what has been called sensitivity analysis in the regulatory setting up to now. Furthermore, the role of sensitivity analysis in regulatory decision-making, although discussed briefly in the NRC report, remains unclear. This paper will examine previous ideas of sensitivity analysis with a view to explaining how the NRC panel's recommendations are different and possibly better suited to coping with present problems of missing data in the regulatory setting. It will also discuss, in more detail than the NRC report, the relevance of sensitivity analysis to decision-making, both for applicants and for regulators. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. PMID:26567763

  13. New Methods for Sensitivity Analysis in Chaotic, Turbulent Fluid Flows

    NASA Astrophysics Data System (ADS)

    Blonigan, Patrick; Wang, Qiqi

    2012-11-01

    Computational methods for sensitivity analysis are invaluable tools for fluid mechanics research and engineering design. These methods are used in many applications, including aerodynamic shape optimization and adaptive grid refinement. However, traditional sensitivity analysis methods break down when applied to long-time averaged quantities in chaotic fluid flowfields, such as those obtained using high-fidelity turbulence simulations. Also, a number of dynamical properties of chaotic fluid flows, most notably the ``Butterfly Effect,'' make the formulation of new sensitivity analysis methods difficult. This talk will outline two chaotic sensitivity analysis methods. The first method, the Fokker-Planck adjoint method, forms a probability density function on the strange attractor associated with the system and uses its adjoint to find gradients. The second method, the Least Squares Sensitivity method, finds some ``shadow trajectory'' in phase space for which perturbations do not grow exponentially. This method is formulated as a quadratic programing problem with linear constraints. This talk is concluded with demonstrations of these new methods on some example problems, including the Lorenz attractor and flow around an airfoil at a high angle of attack.

  14. Imaging system sensitivity analysis with NV-IPM

    NASA Astrophysics Data System (ADS)

    Fanning, Jonathan; Teaney, Brian

    2014-05-01

    This paper describes the sensitivity analysis capabilities to be added to version 1.2 of the NVESD imaging sensor model NV-IPM. Imaging system design always involves tradeoffs to design the best system possible within size, weight, and cost constraints. In general, the performance of a well designed system will be limited by the largest, heaviest, and most expensive components. Modeling is used to analyze system designs before the system is built. Traditionally, NVESD models were only used to determine the performance of a given system design. NV-IPM has the added ability to automatically determine the sensitivity of any system output to changes in the system parameters. The component-based structure of NV-IPM tracks the dependence between outputs and inputs such that only the relevant parameters are varied in the sensitivity analysis. This allows sensitivity analysis of an output such as probability of identification to determine the limiting parameters of the system. Individual components can be optimized by doing sensitivity analysis of outputs such as NETD or SNR. This capability will be demonstrated by analyzing example imaging systems.

  15. Nonparametric Bounds and Sensitivity Analysis of Treatment Effects

    PubMed Central

    Richardson, Amy; Hudgens, Michael G.; Gilbert, Peter B.; Fine, Jason P.

    2015-01-01

    This paper considers conducting inference about the effect of a treatment (or exposure) on an outcome of interest. In the ideal setting where treatment is assigned randomly, under certain assumptions the treatment effect is identifiable from the observable data and inference is straightforward. However, in other settings such as observational studies or randomized trials with noncompliance, the treatment effect is no longer identifiable without relying on untestable assumptions. Nonetheless, the observable data often do provide some information about the effect of treatment, that is, the parameter of interest is partially identifiable. Two approaches are often employed in this setting: (i) bounds are derived for the treatment effect under minimal assumptions, or (ii) additional untestable assumptions are invoked that render the treatment effect identifiable and then sensitivity analysis is conducted to assess how inference about the treatment effect changes as the untestable assumptions are varied. Approaches (i) and (ii) are considered in various settings, including assessing principal strata effects, direct and indirect effects and effects of time-varying exposures. Methods for drawing formal inference about partially identified parameters are also discussed. PMID:25663743

  16. SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool

    PubMed Central

    Zi, Zhike; Zheng, Yanan; Rundell, Ann E; Klipp, Edda

    2008-01-01

    Background It has long been recognized that sensitivity analysis plays a key role in modeling and analyzing cellular and biochemical processes. Systems biology markup language (SBML) has become a well-known platform for coding and sharing mathematical models of such processes. However, current SBML compatible software tools are limited in their ability to perform global sensitivity analyses of these models. Results This work introduces a freely downloadable, software package, SBML-SAT, which implements algorithms for simulation, steady state analysis, robustness analysis and local and global sensitivity analysis for SBML models. This software tool extends current capabilities through its execution of global sensitivity analyses using multi-parametric sensitivity analysis, partial rank correlation coefficient, SOBOL's method, and weighted average of local sensitivity analyses in addition to its ability to handle systems with discontinuous events and intuitive graphical user interface. Conclusion SBML-SAT provides the community of systems biologists a new tool for the analysis of their SBML models of biochemical and cellular processes. PMID:18706080

  17. Multiobjective sensitivity analysis and optimization of distributed hydrologic model MOBIDIC

    NASA Astrophysics Data System (ADS)

    Yang, J.; Castelli, F.; Chen, Y.

    2014-10-01

    Calibration of distributed hydrologic models usually involves how to deal with the large number of distributed parameters and optimization problems with multiple but often conflicting objectives that arise in a natural fashion. This study presents a multiobjective sensitivity and optimization approach to handle these problems for the MOBIDIC (MOdello di Bilancio Idrologico DIstribuito e Continuo) distributed hydrologic model, which combines two sensitivity analysis techniques (the Morris method and the state-dependent parameter (SDP) method) with multiobjective optimization (MOO) approach ɛ-NSGAII (Non-dominated Sorting Genetic Algorithm-II). This approach was implemented to calibrate MOBIDIC with its application to the Davidson watershed, North Carolina, with three objective functions, i.e., the standardized root mean square error (SRMSE) of logarithmic transformed discharge, the water balance index, and the mean absolute error of the logarithmic transformed flow duration curve, and its results were compared with those of a single objective optimization (SOO) with the traditional Nelder-Mead simplex algorithm used in MOBIDIC by taking the objective function as the Euclidean norm of these three objectives. Results show that (1) the two sensitivity analysis techniques are effective and efficient for determining the sensitive processes and insensitive parameters: surface runoff and evaporation are very sensitive processes to all three objective functions, while groundwater recession and soil hydraulic conductivity are not sensitive and were excluded in the optimization. (2) Both MOO and SOO lead to acceptable simulations; e.g., for MOO, the average Nash-Sutcliffe value is 0.75 in the calibration period and 0.70 in the validation period. (3) Evaporation and surface runoff show similar importance for watershed water balance, while the contribution of baseflow can be ignored. (4) Compared to SOO, which was dependent on the initial starting location, MOO provides more

  18. Sensitivity analysis approach to multibody systems described by natural coordinates

    NASA Astrophysics Data System (ADS)

    Li, Xiufeng; Wang, Yabin

    2014-03-01

    The classical natural coordinate modeling method which removes the Euler angles and Euler parameters from the governing equations is particularly suitable for the sensitivity analysis and optimization of multibody systems. However, the formulation has so many principles in choosing the generalized coordinates that it hinders the implementation of modeling automation. A first order direct sensitivity analysis approach to multibody systems formulated with novel natural coordinates is presented. Firstly, a new selection method for natural coordinate is developed. The method introduces 12 coordinates to describe the position and orientation of a spatial object. On the basis of the proposed natural coordinates, rigid constraint conditions, the basic constraint elements as well as the initial conditions for the governing equations are derived. Considering the characteristics of the governing equations, the newly proposed generalized-α integration method is used and the corresponding algorithm flowchart is discussed. The objective function, the detailed analysis process of first order direct sensitivity analysis and related solving strategy are provided based on the previous modeling system. Finally, in order to verify the validity and accuracy of the method presented, the sensitivity analysis of a planar spinner-slider mechanism and a spatial crank-slider mechanism are conducted. The test results agree well with that of the finite difference method, and the maximum absolute deviation of the results is less than 3%. The proposed approach is not only convenient for automatic modeling, but also helpful for the reduction of the complexity of sensitivity analysis, which provides a practical and effective way to obtain sensitivity for the optimization problems of multibody systems.

  19. Seasonality, Rather than Nutrient Addition or Vegetation Types, Influenced Short-Term Temperature Sensitivity of Soil Organic Carbon Decomposition.

    PubMed

    Qian, Yu-Qi; He, Feng-Peng; Wang, Wei

    2016-01-01

    The response of microbial respiration from soil organic carbon (SOC) decomposition to environmental changes plays a key role in predicting future trends of atmospheric CO2 concentration. However, it remains uncertain whether there is a universal trend in the response of microbial respiration to increased temperature and nutrient addition among different vegetation types. In this study, soils were sampled in spring, summer, autumn and winter from five dominant vegetation types, including pine, larch and birch forest, shrubland, and grassland, in the Saihanba area of northern China. Soil samples from each season were incubated at 1, 10, and 20°C for 5 to 7 days. Nitrogen (N; 0.035 mM as NH4NO3) and phosphorus (P; 0.03 mM as P2O5) were added to soil samples, and the responses of soil microbial respiration to increased temperature and nutrient addition were determined. We found a universal trend that soil microbial respiration increased with increased temperature regardless of sampling season or vegetation type. The temperature sensitivity (indicated by Q10, the increase in respiration rate with a 10°C increase in temperature) of microbial respiration was higher in spring and autumn than in summer and winter, irrespective of vegetation type. The Q10 was significantly positively correlated with microbial biomass and the fungal: bacterial ratio. Microbial respiration (or Q10) did not significantly respond to N or P addition. Our results suggest that short-term nutrient input might not change the SOC decomposition rate or its temperature sensitivity, whereas increased temperature might significantly enhance SOC decomposition in spring and autumn, compared with winter and summer. PMID:27070782

  20. Seasonality, Rather than Nutrient Addition or Vegetation Types, Influenced Short-Term Temperature Sensitivity of Soil Organic Carbon Decomposition

    PubMed Central

    He, Feng-Peng; Wang, Wei

    2016-01-01

    The response of microbial respiration from soil organic carbon (SOC) decomposition to environmental changes plays a key role in predicting future trends of atmospheric CO2 concentration. However, it remains uncertain whether there is a universal trend in the response of microbial respiration to increased temperature and nutrient addition among different vegetation types. In this study, soils were sampled in spring, summer, autumn and winter from five dominant vegetation types, including pine, larch and birch forest, shrubland, and grassland, in the Saihanba area of northern China. Soil samples from each season were incubated at 1, 10, and 20°C for 5 to 7 days. Nitrogen (N; 0.035 mM as NH4NO3) and phosphorus (P; 0.03 mM as P2O5) were added to soil samples, and the responses of soil microbial respiration to increased temperature and nutrient addition were determined. We found a universal trend that soil microbial respiration increased with increased temperature regardless of sampling season or vegetation type. The temperature sensitivity (indicated by Q10, the increase in respiration rate with a 10°C increase in temperature) of microbial respiration was higher in spring and autumn than in summer and winter, irrespective of vegetation type. The Q10 was significantly positively correlated with microbial biomass and the fungal: bacterial ratio. Microbial respiration (or Q10) did not significantly respond to N or P addition. Our results suggest that short-term nutrient input might not change the SOC decomposition rate or its temperature sensitivity, whereas increased temperature might significantly enhance SOC decomposition in spring and autumn, compared with winter and summer. PMID:27070782

  1. Sensitivity analysis of the fission gas behavior model in BISON.

    SciTech Connect

    Swiler, Laura Painton; Pastore, Giovanni; Perez, Danielle; Williamson, Richard

    2013-05-01

    This report summarizes the result of a NEAMS project focused on sensitivity analysis of a new model for the fission gas behavior (release and swelling) in the BISON fuel performance code of Idaho National Laboratory. Using the new model in BISON, the sensitivity of the calculated fission gas release and swelling to the involved parameters and the associated uncertainties is investigated. The study results in a quantitative assessment of the role of intrinsic uncertainties in the analysis of fission gas behavior in nuclear fuel.

  2. Sensitivity analysis for handling uncertainty in an economic evaluation.

    PubMed

    Limwattananon, Supon

    2014-05-01

    To meet updated international standards, this paper revises the previous Thai guidelines for conducting sensitivity analyses as part of the decision analysis model for health technology assessment. It recommends both deterministic and probabilistic sensitivity analyses to handle uncertainty of the model parameters, which are best represented graphically. Two new methodological issues are introduced-a threshold analysis of medicines' unit prices for fulfilling the National Lists of Essential Medicines' requirements and the expected value of information for delaying decision-making in contexts where there are high levels of uncertainty. Further research is recommended where parameter uncertainty is significant and where the cost of conducting the research is not prohibitive. PMID:24964700

  3. Sensitivity Analysis for Coupled Aero-structural Systems

    NASA Technical Reports Server (NTRS)

    Giunta, Anthony A.

    1999-01-01

    A novel method has been developed for calculating gradients of aerodynamic force and moment coefficients for an aeroelastic aircraft model. This method uses the Global Sensitivity Equations (GSE) to account for the aero-structural coupling, and a reduced-order modal analysis approach to condense the coupling bandwidth between the aerodynamic and structural models. Parallel computing is applied to reduce the computational expense of the numerous high fidelity aerodynamic analyses needed for the coupled aero-structural system. Good agreement is obtained between aerodynamic force and moment gradients computed with the GSE/modal analysis approach and the same quantities computed using brute-force, computationally expensive, finite difference approximations. A comparison between the computational expense of the GSE/modal analysis method and a pure finite difference approach is presented. These results show that the GSE/modal analysis approach is the more computationally efficient technique if sensitivity analysis is to be performed for two or more aircraft design parameters.

  4. What Constitutes a "Good" Sensitivity Analysis? Elements and Tools for a Robust Sensitivity Analysis with Reduced Computational Cost

    NASA Astrophysics Data System (ADS)

    Razavi, Saman; Gupta, Hoshin; Haghnegahdar, Amin

    2016-04-01

    Global sensitivity analysis (GSA) is a systems theoretic approach to characterizing the overall (average) sensitivity of one or more model responses across the factor space, by attributing the variability of those responses to different controlling (but uncertain) factors (e.g., model parameters, forcings, and boundary and initial conditions). GSA can be very helpful to improve the credibility and utility of Earth and Environmental System Models (EESMs), as these models are continually growing in complexity and dimensionality with continuous advances in understanding and computing power. However, conventional approaches to GSA suffer from (1) an ambiguous characterization of sensitivity, and (2) poor computational efficiency, particularly as the problem dimension grows. Here, we identify several important sensitivity-related characteristics of response surfaces that must be considered when investigating and interpreting the ''global sensitivity'' of a model response (e.g., a metric of model performance) to its parameters/factors. Accordingly, we present a new and general sensitivity and uncertainty analysis framework, Variogram Analysis of Response Surfaces (VARS), based on an analogy to 'variogram analysis', that characterizes a comprehensive spectrum of information on sensitivity. We prove, theoretically, that Morris (derivative-based) and Sobol (variance-based) methods and their extensions are special cases of VARS, and that their SA indices are contained within the VARS framework. We also present a practical strategy for the application of VARS to real-world problems, called STAR-VARS, including a new sampling strategy, called "star-based sampling". Our results across several case studies show the STAR-VARS approach to provide reliable and stable assessments of "global" sensitivity, while being at least 1-2 orders of magnitude more efficient than the benchmark Morris and Sobol approaches.

  5. Adjoint-based sensitivity analysis for reactor-safety applications

    SciTech Connect

    Parks, C.V.

    1985-01-01

    The application and usefulness of an adjoint-based methodology for performing sensitivity analysis on reactor safety computer codes is investigated. The adjoint-based methodology, referred to as differential sensitivity theory (DST), provides first-order derivatives of the calculated quantities of interest (responses) with respect to the input parameters. The basic theoretical development of DST is presented along with the needed general extensions for consideration of model discontinuities and a variety of useful response definitions. A simple analytic problem is used to highlight the general DST procedures. Finally, DST procedures presented in this work are applied to two highly nonlinear reactor accident analysis codes: (1) FASTGAS, a relatively small code for analysis of loss-of-decay-heat-removal accident in a gas-cooled fast reactor, and (2) an existing code called VENUS-II which is typically employed for analyzing the core disassembly phase of a hypothetical fast reactor accident. The two codes are different both in terms of complexity and in terms of the facets of DST which can be illustrated. Sensitivity results from the adjoint codes ADJGAS and VENUS-ADJ are verified with direct recalculations using perturbed input parameters. The effectiveness of the DST results for parameter ranking, prediction of response changes, and uncertainty analysis are illustrated. The conclusion drawn from this study is that DST is a viable, cost-effective methodology for accurate sensitivity analysis.

  6. A Global Sensitivity Analysis Methodology for Multi-physics Applications

    SciTech Connect

    Tong, C H; Graziani, F R

    2007-02-02

    Experiments are conducted to draw inferences about an entire ensemble based on a selected number of observations. This applies to both physical experiments as well as computer experiments, the latter of which are performed by running the simulation models at different input configurations and analyzing the output responses. Computer experiments are instrumental in enabling model analyses such as uncertainty quantification and sensitivity analysis. This report focuses on a global sensitivity analysis methodology that relies on a divide-and-conquer strategy and uses intelligent computer experiments. The objective is to assess qualitatively and/or quantitatively how the variabilities of simulation output responses can be accounted for by input variabilities. We address global sensitivity analysis in three aspects: methodology, sampling/analysis strategies, and an implementation framework. The methodology consists of three major steps: (1) construct credible input ranges; (2) perform a parameter screening study; and (3) perform a quantitative sensitivity analysis on a reduced set of parameters. Once identified, research effort should be directed to the most sensitive parameters to reduce their uncertainty bounds. This process is repeated with tightened uncertainty bounds for the sensitive parameters until the output uncertainties become acceptable. To accommodate the needs of multi-physics application, this methodology should be recursively applied to individual physics modules. The methodology is also distinguished by an efficient technique for computing parameter interactions. Details for each step will be given using simple examples. Numerical results on large scale multi-physics applications will be available in another report. Computational techniques targeted for this methodology have been implemented in a software package called PSUADE.

  7. LSENS - GENERAL CHEMICAL KINETICS AND SENSITIVITY ANALYSIS CODE

    NASA Technical Reports Server (NTRS)

    Bittker, D. A.

    1994-01-01

    LSENS has been developed for solving complex, homogeneous, gas-phase, chemical kinetics problems. The motivation for the development of this program is the continuing interest in developing detailed chemical reaction mechanisms for complex reactions such as the combustion of fuels and pollutant formation and destruction. A reaction mechanism is the set of all elementary chemical reactions that are required to describe the process of interest. Mathematical descriptions of chemical kinetics problems constitute sets of coupled, nonlinear, first-order ordinary differential equations (ODEs). The number of ODEs can be very large because of the numerous chemical species involved in the reaction mechanism. Further complicating the situation are the many simultaneous reactions needed to describe the chemical kinetics of practical fuels. For example, the mechanism describing the oxidation of the simplest hydrocarbon fuel, methane, involves over 25 species participating in nearly 100 elementary reaction steps. Validating a chemical reaction mechanism requires repetitive solutions of the governing ODEs for a variety of reaction conditions. Analytical solutions to the systems of ODEs describing chemistry are not possible, except for the simplest cases, which are of little or no practical value. Consequently, there is a need for fast and reliable numerical solution techniques for chemical kinetics problems. In addition to solving the ODEs describing chemical kinetics, it is often necessary to know what effects variations in either initial condition values or chemical reaction mechanism parameters have on the solution. Such a need arises in the development of reaction mechanisms from experimental data. The rate coefficients are often not known with great precision and in general, the experimental data are not sufficiently detailed to accurately estimate the rate coefficient parameters. The development of a reaction mechanism is facilitated by a systematic sensitivity analysis

  8. Adjoint sensitivity analysis of plasmonic structures using the FDTD method.

    PubMed

    Zhang, Yu; Ahmed, Osman S; Bakr, Mohamed H

    2014-05-15

    We present an adjoint variable method for estimating the sensitivities of arbitrary responses with respect to the parameters of dispersive discontinuities in nanoplasmonic devices. Our theory is formulated in terms of the electric field components at the vicinity of perturbed discontinuities. The adjoint sensitivities are computed using at most one extra finite-difference time-domain (FDTD) simulation regardless of the number of parameters. Our approach is illustrated through the sensitivity analysis of an add-drop coupler consisting of a square ring resonator between two parallel waveguides. The computed adjoint sensitivities of the scattering parameters are compared with those obtained using the accurate but computationally expensive central finite difference approach. PMID:24978258

  9. Additional analysis of dendrochemical data of Fallon, Nevada.

    PubMed

    Sheppard, Paul R; Helsel, Dennis R; Speakman, Robert J; Ridenour, Gary; Witten, Mark L

    2012-04-01

    Previously reported dendrochemical data showed temporal variability in concentration of tungsten (W) and cobalt (Co) in tree rings of Fallon, Nevada, US. Criticism of this work questioned the use of the Mann-Whitney test for determining change in element concentrations. Here, we demonstrate that Mann-Whitney is appropriate for comparing background element concentrations to possibly elevated concentrations in environmental media. Given that Mann-Whitney tests for differences in shapes of distributions, inter-tree variability (e.g., "coefficient of median variation") was calculated for each measured element across trees within subsites and time periods. For W and Co, the metals of highest interest in Fallon, inter-tree variability was always higher within versus outside of Fallon. For calibration purposes, this entire analysis was repeated at a different town, Sweet Home, Oregon, which has a known tungsten-powder facility, and inter-tree variability of W in tree rings confirmed the establishment date of that facility. Mann-Whitney testing of simulated data also confirmed its appropriateness for analysis of data affected by point-source contamination. This research adds important new dimensions to dendrochemistry of point-source contamination by adding analysis of inter-tree variability to analysis of central tendency. Fallon remains distinctive by a temporal increase in W beginning by the mid 1990s and by elevated Co since at least the early 1990s, as well as by high inter-tree variability for W and Co relative to comparison towns. PMID:22227064

  10. Sensitivity analysis in a Lassa fever deterministic mathematical model

    NASA Astrophysics Data System (ADS)

    Abdullahi, Mohammed Baba; Doko, Umar Chado; Mamuda, Mamman

    2015-05-01

    Lassa virus that causes the Lassa fever is on the list of potential bio-weapons agents. It was recently imported into Germany, the Netherlands, the United Kingdom and the United States as a consequence of the rapid growth of international traffic. A model with five mutually exclusive compartments related to Lassa fever is presented and the basic reproduction number analyzed. A sensitivity analysis of the deterministic model is performed. This is done in order to determine the relative importance of the model parameters to the disease transmission. The result of the sensitivity analysis shows that the most sensitive parameter is the human immigration, followed by human recovery rate, then person to person contact. This suggests that control strategies should target human immigration, effective drugs for treatment and education to reduced person to person contact.

  11. Uncertainty and sensitivity analysis and its applications in OCD measurements

    NASA Astrophysics Data System (ADS)

    Vagos, Pedro; Hu, Jiangtao; Liu, Zhuan; Rabello, Silvio

    2009-03-01

    This article describes an Uncertainty & Sensitivity Analysis package, a mathematical tool that can be an effective time-shortcut for optimizing OCD models. By including real system noises in the model, an accurate method for predicting measurements uncertainties is shown. The assessment, in an early stage, of the uncertainties, sensitivities and correlations of the parameters to be measured drives the user in the optimization of the OCD measurement strategy. Real examples are discussed revealing common pitfalls like hidden correlations and simulation results are compared with real measurements. Special emphasis is given to 2 different cases: 1) the optimization of the data set of multi-head metrology tools (NI-OCD, SE-OCD), 2) the optimization of the azimuth measurement angle in SE-OCD. With the uncertainty and sensitivity analysis result, the right data set and measurement mode (NI-OCD, SE-OCD or NI+SE OCD) can be easily selected to achieve the best OCD model performance.

  12. Blurring the Inputs: A Natural Language Approach to Sensitivity Analysis

    NASA Technical Reports Server (NTRS)

    Kleb, William L.; Thompson, Richard A.; Johnston, Christopher O.

    2007-01-01

    To document model parameter uncertainties and to automate sensitivity analyses for numerical simulation codes, a natural-language-based method to specify tolerances has been developed. With this new method, uncertainties are expressed in a natural manner, i.e., as one would on an engineering drawing, namely, 5.25 +/- 0.01. This approach is robust and readily adapted to various application domains because it does not rely on parsing the particular structure of input file formats. Instead, tolerances of a standard format are added to existing fields within an input file. As a demonstration of the power of this simple, natural language approach, a Monte Carlo sensitivity analysis is performed for three disparate simulation codes: fluid dynamics (LAURA), radiation (HARA), and ablation (FIAT). Effort required to harness each code for sensitivity analysis was recorded to demonstrate the generality and flexibility of this new approach.

  13. Computational methods for efficient structural reliability and reliability sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Wu, Y.-T.

    1993-01-01

    This paper presents recent developments in efficient structural reliability analysis methods. The paper proposes an efficient, adaptive importance sampling (AIS) method that can be used to compute reliability and reliability sensitivities. The AIS approach uses a sampling density that is proportional to the joint PDF of the random variables. Starting from an initial approximate failure domain, sampling proceeds adaptively and incrementally with the goal of reaching a sampling domain that is slightly greater than the failure domain to minimize over-sampling in the safe region. Several reliability sensitivity coefficients are proposed that can be computed directly and easily from the above AIS-based failure points. These probability sensitivities can be used for identifying key random variables and for adjusting design to achieve reliability-based objectives. The proposed AIS methodology is demonstrated using a turbine blade reliability analysis problem.

  14. Sensitivity analysis of the critical speed in railway vehicle dynamics

    NASA Astrophysics Data System (ADS)

    Bigoni, D.; True, H.; Engsig-Karup, A. P.

    2014-05-01

    We present an approach to global sensitivity analysis aiming at the reduction of its computational cost without compromising the results. The method is based on sampling methods, cubature rules, high-dimensional model representation and total sensitivity indices. It is applied to a half car with a two-axle Cooperrider bogie, in order to study the sensitivity of the critical speed with respect to the suspension parameters. The importance of a certain suspension component is expressed by the variance in critical speed that is ascribable to it. This proves to be useful in the identification of parameters for which the accuracy of their values is critically important. The approach has a general applicability in many engineering fields and does not require the knowledge of the particular solver of the dynamical system. This analysis can be used as part of the virtual homologation procedure and to help engineers during the design phase of complex systems.

  15. Porosity Measurements and Analysis for Metal Additive Manufacturing Process Control

    PubMed Central

    Slotwinski, John A; Garboczi, Edward J; Hebenstreit, Keith M

    2014-01-01

    Additive manufacturing techniques can produce complex, high-value metal parts, with potential applications as critical metal components such as those found in aerospace engines and as customized biomedical implants. Material porosity in these parts is undesirable for aerospace parts - since porosity could lead to premature failure - and desirable for some biomedical implants - since surface-breaking pores allows for better integration with biological tissue. Changes in a part’s porosity during an additive manufacturing build may also be an indication of an undesired change in the build process. Here, we present efforts to develop an ultrasonic sensor for monitoring changes in the porosity in metal parts during fabrication on a metal powder bed fusion system. The development of well-characterized reference samples, measurements of the porosity of these samples with multiple techniques, and correlation of ultrasonic measurements with the degree of porosity are presented. A proposed sensor design, measurement strategy, and future experimental plans on a metal powder bed fusion system are also presented. PMID:26601041

  16. Porosity Measurements and Analysis for Metal Additive Manufacturing Process Control.

    PubMed

    Slotwinski, John A; Garboczi, Edward J; Hebenstreit, Keith M

    2014-01-01

    Additive manufacturing techniques can produce complex, high-value metal parts, with potential applications as critical metal components such as those found in aerospace engines and as customized biomedical implants. Material porosity in these parts is undesirable for aerospace parts - since porosity could lead to premature failure - and desirable for some biomedical implants - since surface-breaking pores allows for better integration with biological tissue. Changes in a part's porosity during an additive manufacturing build may also be an indication of an undesired change in the build process. Here, we present efforts to develop an ultrasonic sensor for monitoring changes in the porosity in metal parts during fabrication on a metal powder bed fusion system. The development of well-characterized reference samples, measurements of the porosity of these samples with multiple techniques, and correlation of ultrasonic measurements with the degree of porosity are presented. A proposed sensor design, measurement strategy, and future experimental plans on a metal powder bed fusion system are also presented. PMID:26601041

  17. Beyond the GUM: variance-based sensitivity analysis in metrology

    NASA Astrophysics Data System (ADS)

    Lira, I.

    2016-07-01

    Variance-based sensitivity analysis is a well established tool for evaluating the contribution of the uncertainties in the inputs to the uncertainty in the output of a general mathematical model. While the literature on this subject is quite extensive, it has not found widespread use in metrological applications. In this article we present a succinct review of the fundamentals of sensitivity analysis, in a form that should be useful to most people familiarized with the Guide to the Expression of Uncertainty in Measurement (GUM). Through two examples, it is shown that in linear measurement models, no new knowledge is gained by using sensitivity analysis that is not already available after the terms in the so-called ‘law of propagation of uncertainties’ have been computed. However, if the model behaves non-linearly in the neighbourhood of the best estimates of the input quantities—and if these quantities are assumed to be statistically independent—sensitivity analysis is definitely advantageous for gaining insight into how they can be ranked according to their importance in establishing the uncertainty of the measurand.

  18. Sensitivity analysis of the Ohio phosphorus risk index

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Phosphorus (P) Index is a widely used tool for assessing the vulnerability of agricultural fields to P loss; yet, few of the P Indices developed in the U.S. have been evaluated for their accuracy. Sensitivity analysis is one approach that can be used prior to calibration and field-scale testing ...

  19. Omitted Variable Sensitivity Analysis with the Annotated Love Plot

    ERIC Educational Resources Information Center

    Hansen, Ben B.; Fredrickson, Mark M.

    2014-01-01

    The goal of this research is to make sensitivity analysis accessible not only to empirical researchers but also to the various stakeholders for whom educational evaluations are conducted. To do this it derives anchors for the omitted variable (OV)-program participation association intrinsically, using the Love plot to present a wide range of…

  20. Disclosure of hydraulic fracturing fluid chemical additives: analysis of regulations.

    PubMed

    Maule, Alexis L; Makey, Colleen M; Benson, Eugene B; Burrows, Isaac J; Scammell, Madeleine K

    2013-01-01

    Hydraulic fracturing is used to extract natural gas from shale formations. The process involves injecting into the ground fracturing fluids that contain thousands of gallons of chemical additives. Companies are not mandated by federal regulations to disclose the identities or quantities of chemicals used during hydraulic fracturing operations on private or public lands. States have begun to regulate hydraulic fracturing fluids by mandating chemical disclosure. These laws have shortcomings including nondisclosure of proprietary or "trade secret" mixtures, insufficient penalties for reporting inaccurate or incomplete information, and timelines that allow for after-the-fact reporting. These limitations leave lawmakers, regulators, public safety officers, and the public uninformed and ill-prepared to anticipate and respond to possible environmental and human health hazards associated with hydraulic fracturing fluids. We explore hydraulic fracturing exemptions from federal regulations, as well as current and future efforts to mandate chemical disclosure at the federal and state level. PMID:23552653

  1. Integrative "omic" analysis for tamoxifen sensitivity through cell based models.

    PubMed

    Weng, Liming; Ziliak, Dana; Lacroix, Bonnie; Geeleher, Paul; Huang, R Stephanie

    2014-01-01

    It has long been observed that tamoxifen sensitivity varies among breast cancer patients. Further, ethnic differences of tamoxifen therapy between Caucasian and African American have also been reported. Since most studies have been focused on Caucasian people, we sought to comprehensively evaluate genetic variants related to tamoxifen therapy in African-derived samples. An integrative "omic" approach developed by our group was used to investigate relationships among endoxifen (an active metabolite of tamoxifen) sensitivity, SNP genotype, mRNA and microRNA expressions in 58 HapMap YRI lymphoblastoid cell lines. We identified 50 SNPs that associate with cellular sensitivity to endoxifen through their effects on 34 genes and 30 microRNA expression. Some of these findings are shared in both Caucasian and African samples, while others are unique in the African samples. Among gene/microRNA that were identified in both ethnic groups, the expression of TRAF1 is also correlated with tamoxifen sensitivity in a collection of 44 breast cancer cell lines. Further, knock-down TRAF1 and over-expression of hsa-let-7i confirmed the roles of hsa-let-7i and TRAF1 in increasing tamoxifen sensitivity in the ZR-75-1 breast cancer cell line. Our integrative omic analysis facilitated the discovery of pharmacogenomic biomarkers that potentially affect tamoxifen sensitivity. PMID:24699530

  2. Urea as a long-term stable alternative to guanidium thiocyanate additive in dye-sensitized solar cell

    NASA Astrophysics Data System (ADS)

    Kim, Mi-Jeong; Park, Nam-Gyu

    2012-09-01

    Photovoltaic performance of 0.05 M urea-contained redox electrolyte is compared to that of 0.05 M guanidinium thiocyanate (GSCN)-contained one in dye-sensitized solar cell. No significant difference in the initial photovoltaic performance is observed, which means that the role of urea additive is similar to that of GSCN. Initial solar-to-electrical conversion efficiency of the device containing GSCN shows 7% that is diminished to 5.8% after 40 days, whereas the device containing urea exhibits stable photovoltaic performance showing that initial efficiency of 7.2% is almost remained unchanged after 40 days (7.1%). The lowered efficiency of the GSCN-contained device is mainly due to the decreased photocurrent density, which is ascribed to the formation of needle-shaped crystals on TiO2 layer. Infrared spectroscopic study confirms that the crystals are dye analogue, which is indicative of dye desorption in the presence of GSCN. On the other hand, no crystals are formed in the urea-contained electrolyte, which implies that dye desorption is negligible. Urea additive is thus found to be less reactive in dye desorption than GSCN, leading to long-term stability.

  3. Sensitivity analysis of TOPSIS method in water quality assessment II: sensitivity to the index input data.

    PubMed

    Li, Peiyue; Wu, Jianhua; Qian, Hui; Chen, Jie

    2013-03-01

    This is the second part of the study on sensitivity analysis of the technique for order preference by similarity to ideal solution (TOPSIS) method in water quality assessment. In the present study, the sensitivity of the TOPSIS method to the index input data was investigated. The sensitivity was first theoretically analyzed under two major assumptions. One assumption was that one index or more of the samples were perturbed with the same ratio while other indices kept unchanged. The other one was that all indices of a given sample were changed simultaneously with the same ratio, while the indices of other samples were unchanged. Furthermore, a case study under assumption 2 was also carried out in this paper. When the same indices of different water samples are changed simultaneously with the same variation ratio, the final water quality assessment results will not be influenced at all. When the input data of all indices of a given sample are perturbed with the same variation ratio, the assessment values of all samples will be influenced theoretically. However, the case study shows that only the perturbed sample is sensitive to the variation, and a simple linear equation representing the relation between the closeness coefficient (CC) values of the perturbed sample and variation ratios can be derived under the assumption 2. This linear equation can be used for determining the sample orders under various variation ratios. PMID:22832843

  4. Nonlinear mathematical modeling and sensitivity analysis of hydraulic drive unit

    NASA Astrophysics Data System (ADS)

    Kong, Xiangdong; Yu, Bin; Quan, Lingxiao; Ba, Kaixian; Wu, Liujie

    2015-09-01

    The previous sensitivity analysis researches are not accurate enough and also have the limited reference value, because those mathematical models are relatively simple and the change of the load and the initial displacement changes of the piston are ignored, even experiment verification is not conducted. Therefore, in view of deficiencies above, a nonlinear mathematical model is established in this paper, including dynamic characteristics of servo valve, nonlinear characteristics of pressure-flow, initial displacement of servo cylinder piston and friction nonlinearity. The transfer function block diagram is built for the hydraulic drive unit closed loop position control, as well as the state equations. Through deriving the time-varying coefficient items matrix and time-varying free items matrix of sensitivity equations respectively, the expression of sensitivity equations based on the nonlinear mathematical model are obtained. According to structure parameters of hydraulic drive unit, working parameters, fluid transmission characteristics and measured friction-velocity curves, the simulation analysis of hydraulic drive unit is completed on the MATLAB/Simulink simulation platform with the displacement step 2 mm, 5 mm and 10 mm, respectively. The simulation results indicate that the developed nonlinear mathematical model is sufficient by comparing the characteristic curves of experimental step response and simulation step response under different constant load. Then, the sensitivity function time-history curves of seventeen parameters are obtained, basing on each state vector time-history curve of step response characteristic. The maximum value of displacement variation percentage and the sum of displacement variation absolute values in the sampling time are both taken as sensitivity indexes. The sensitivity indexes values above are calculated and shown visually in histograms under different working conditions, and change rules are analyzed. Then the sensitivity

  5. Sensitivity analysis and scale issues in landslide susceptibility mapping

    NASA Astrophysics Data System (ADS)

    Catani, Filippo; Lagomarsino, Daniela; Segoni, Samuele; Tofani, Veronica

    2013-04-01

    Despite the large number of recent advances and developments in landslide susceptibility mapping (LSM) there is still a lack of studies focusing on specific aspects of LSM model sensitivity. For example, the influence of factors of paramount importance such as the survey scale of the landslide conditioning variables (LCVs), the resolution of the mapping unit (MUR) and the optimal number and ranking of LCVs have never been investigated analytically, especially on large datasets. In this paper we attempt this experimentation concentrating on the impact of model tuning choice on the final result, rather than on the comparison of methodologies. To this end, we adopt a simple implementation of the random forest (RF) classification family to produce an ensamble of landslide susceptibility maps for a set of different model settings, input data types and scales. RF classification and regression methods offer a very flexible environment for testing model parameters and mapping hypotheses, allowing for a direct quantification of variable importance. The model choice is, in itself, quite innovative since it is the first time that such technique, widely used in remote sensing for image classification, is used in this form for the production of a LSM. Random forest is a combination of tree (usually binary) bayesian predictors that permits to relate a set of contributing factors with the actual landslides occurrence. Being it a nonparametric model, it is possible to incorporate a range of numeric or categorical data layers and there is no need to select unimodal training data. Many classical and widely acknowledged landslide predisposing factors have been taken into account as mainly related to: the lithology, the land use, the land surface geometry (derived from DTM), the structural and anthropogenic constrains. In addition, for each factor we also included in the parameter set the standard deviation (for numerical variables) or the variety (for categorical ones). The use of

  6. Sensitivity Analysis of Chaotic Flow around Two-Dimensional Airfoil

    NASA Astrophysics Data System (ADS)

    Blonigan, Patrick; Wang, Qiqi; Nielsen, Eric; Diskin, Boris

    2015-11-01

    Computational methods for sensitivity analysis are invaluable tools for fluid dynamics research and engineering design. These methods are used in many applications, including aerodynamic shape optimization and adaptive grid refinement. However, traditional sensitivity analysis methods, including the adjoint method, break down when applied to long-time averaged quantities in chaotic fluid flow fields, such as high-fidelity turbulence simulations. This break down is due to the ``Butterfly Effect'' the high sensitivity of chaotic dynamical systems to the initial condition. A new sensitivity analysis method developed by the authors, Least Squares Shadowing (LSS), can compute useful and accurate gradients for quantities of interest in chaotic dynamical systems. LSS computes gradients using the ``shadow trajectory'', a phase space trajectory (or solution) for which perturbations to the flow field do not grow exponentially in time. To efficiently compute many gradients for one objective function, we use an adjoint version of LSS. This talk will briefly outline Least Squares Shadowing and demonstrate it on chaotic flow around a Two-Dimensional airfoil.

  7. Double Precision Differential/Algebraic Sensitivity Analysis Code

    1995-06-02

    DDASAC solves nonlinear initial-value problems involving stiff implicit systems of ordinary differential and algebraic equations. Purely algebraic nonlinear systems can also be solved, given an initial guess within the region of attraction of a solution. Options include automatic reconciliation of inconsistent initial states and derivatives, automatic initial step selection, direct concurrent parametric sensitivity analysis, and stopping at a prescribed value of any user-defined functional of the current solution vector. Local error control (in the max-normmore » or the 2-norm) is provided for the state vector and can include the sensitivities on request.« less

  8. Sensitivity Analysis Of Technological And Material Parameters In Roll Forming

    NASA Astrophysics Data System (ADS)

    Gehring, Albrecht; Saal, Helmut

    2007-05-01

    Roll forming is applied for several decades to manufacture thin gauged profiles. However, the knowledge about this technology is still based on empirical approaches. Due to the complexity of the forming process, the main effects on profile properties are difficult to identify. This is especially true for the interaction of technological parameters and material parameters. General considerations for building a finite-element model of the roll forming process are given in this paper. A sensitivity analysis is performed on base of a statistical design approach in order to identify the effects and interactions of different parameters on profile properties. The parameters included in the analysis are the roll diameter, the rolling speed, the sheet thickness, friction between the tools and the sheet and the strain hardening behavior of the sheet material. The analysis includes an isotropic hardening model and a nonlinear kinematic hardening model. All jobs are executed parallel to reduce the overall time as the sensitivity analysis requires much CPU-time. The results of the sensitivity analysis demonstrate the opportunities to improve the properties of roll formed profiles by adjusting technological and material parameters to their optimum interacting performance.

  9. Identification of carbonates as additives in pressure-sensitive adhesive tape substrate with Fourier transform infrared spectroscopy (FTIR) and its application in three explosive cases.

    PubMed

    Lv, Jungang; Feng, Jimin; Zhang, Wen; Shi, Rongguang; Liu, Yong; Wang, Zhaohong; Zhao, Meng

    2013-01-01

    Pressure-sensitive tape is often used to bind explosive devices. It can become important trace evidence in many cases. Three types of calcium carbonate (heavy, light, and active CaCO(3)), which were widely used as additives in pressure-sensitive tape substrate, were analyzed with Fourier transform infrared spectroscopy (FTIR) in this study. A Spectrum GX 2000 system with a diamond anvil cell and a deuterated triglycine sulfate detector was employed for IR observation. Background was subtracted for every measurement, and triplicate tests were performed. Differences in positions of main peaks and the corresponding functional groups were investigated. Heavy CaCO(3) could be identified from the two absorptions near 873 and 855/cm, while light CaCO(3) only has one peak near 873/cm because of the low content of aragonite. Active CaCO(3) could be identified from the absorptions in the 2800-2900/cm region because of the existence of organic compounds. Tiny but indicative changes in the 878-853/cm region were found in the spectra of CaCO(3) with different content of aragonite and calcite. CaCO(3) in pressure-sensitive tape, which cannot be differentiated by scanning electron microscope/energy dispersive X-ray spectrometer and thermal analysis, can be easily identified using FTIR. The findings were successfully applied to three specific explosive cases and would be helpful in finding the possible source of explosive devices in future cases. PMID:22724657

  10. Additional challenges for uncertainty analysis in river engineering

    NASA Astrophysics Data System (ADS)

    Berends, Koen; Warmink, Jord; Hulscher, Suzanne

    2016-04-01

    the proposed intervention. The implicit assumption underlying such analysis is that both models are commensurable. We hypothesize that they are commensurable only to a certain extent. In an idealised study we have demonstrated that prediction performance loss should be expected with increasingly large engineering works. When accounting for parametric uncertainty of floodplain roughness in model identification, we see uncertainty bounds for predicted effects of interventions increase with increasing intervention scale. Calibration of these types of models therefore seems to have a shelf-life, beyond which calibration does not longer improves prediction. Therefore a qualification scheme for model use is required that can be linked to model validity. In this study, we characterize model use along three dimensions: extrapolation (using the model with different external drivers), extension (using the model for different output or indicators) and modification (using modified models). Such use of models is expected to have implications for the applicability of surrogating modelling for efficient uncertainty analysis as well, which is recommended for future research. Warmink, J. J.; Straatsma, M. W.; Huthoff, F.; Booij, M. J. & Hulscher, S. J. M. H. 2013. Uncertainty of design water levels due to combined bed form and vegetation roughness in the Dutch river Waal. Journal of Flood Risk Management 6, 302-318 . DOI: 10.1111/jfr3.12014

  11. Efficient sensitivity analysis and optimization of a helicopter rotor

    NASA Technical Reports Server (NTRS)

    Lim, Joon W.; Chopra, Inderjit

    1989-01-01

    Aeroelastic optimization of a system essentially consists of the determination of the optimum values of design variables which minimize the objective function and satisfy certain aeroelastic and geometric constraints. The process of aeroelastic optimization analysis is illustrated. To carry out aeroelastic optimization effectively, one needs a reliable analysis procedure to determine steady response and stability of a rotor system in forward flight. The rotor dynamic analysis used in the present study developed inhouse at the University of Maryland is based on finite elements in space and time. The analysis consists of two major phases: vehicle trim and rotor steady response (coupled trim analysis), and aeroelastic stability of the blade. For a reduction of helicopter vibration, the optimization process requires the sensitivity derivatives of the objective function and aeroelastic stability constraints. For this, the derivatives of steady response, hub loads and blade stability roots are calculated using a direct analytical approach. An automated optimization procedure is developed by coupling the rotor dynamic analysis, design sensitivity analysis and constrained optimization code CONMIN.

  12. Sensitivity Analysis of the Static Aeroelastic Response of a Wing

    NASA Technical Reports Server (NTRS)

    Eldred, Lloyd B.

    1993-01-01

    A technique to obtain the sensitivity of the static aeroelastic response of a three dimensional wing model is designed and implemented. The formulation is quite general and accepts any aerodynamic and structural analysis capability. A program to combine the discipline level, or local, sensitivities into global sensitivity derivatives is developed. A variety of representations of the wing pressure field are developed and tested to determine the most accurate and efficient scheme for representing the field outside of the aerodynamic code. Chebyshev polynomials are used to globally fit the pressure field. This approach had some difficulties in representing local variations in the field, so a variety of local interpolation polynomial pressure representations are also implemented. These panel based representations use a constant pressure value, a bilinearly interpolated value. or a biquadraticallv interpolated value. The interpolation polynomial approaches do an excellent job of reducing the numerical problems of the global approach for comparable computational effort. Regardless of the pressure representation used. sensitivity and response results with excellent accuracy have been produced for large integrated quantities such as wing tip deflection and trim angle of attack. The sensitivities of such things as individual generalized displacements have been found with fair accuracy. In general, accuracy is found to be proportional to the relative size of the derivatives to the quantity itself.

  13. Shape sensitivity analysis of flutter response of a laminated wing

    NASA Technical Reports Server (NTRS)

    Bergen, Fred D.; Kapania, Rakesh K.

    1988-01-01

    A method is presented for calculating the shape sensitivity of a wing aeroelastic response with respect to changes in geometric shape. Yates' modified strip method is used in conjunction with Giles' equivalent plate analysis to predict the flutter speed, frequency, and reduced frequency of the wing. Three methods are used to calculate the sensitivity of the eigenvalue. The first method is purely a finite difference calculation of the eigenvalue derivative directly from the solution of the flutter problem corresponding to the two different values of the shape parameters. The second method uses an analytic expression for the eigenvalue sensitivities of a general complex matrix, where the derivatives of the aerodynamic, mass, and stiffness matrices are computed using a finite difference approximation. The third method also uses an analytic expression for the eigenvalue sensitivities, but the aerodynamic matrix is computed analytically. All three methods are found to be in good agreement with each other. The sensitivities of the eigenvalues were used to predict the flutter speed, frequency, and reduced frequency. These approximations were found to be in good agreement with those obtained using a complete reanalysis.

  14. Graphical methods for the sensitivity analysis in discriminant analysis

    SciTech Connect

    Kim, Youngil; Anderson-Cook, Christine M.; Dae-Heung, Jang

    2015-09-30

    Similar to regression, many measures to detect influential data points in discriminant analysis have been developed. Many follow similar principles as the diagnostic measures used in linear regression in the context of discriminant analysis. Here we focus on the impact on the predicted classification posterior probability when a data point is omitted. The new method is intuitive and easily interpretative compared to existing methods. We also propose a graphical display to show the individual movement of the posterior probability of other data points when a specific data point is omitted. This enables the summaries to capture the overall pattern of the change.

  15. Graphical methods for the sensitivity analysis in discriminant analysis

    DOE PAGESBeta

    Kim, Youngil; Anderson-Cook, Christine M.; Dae-Heung, Jang

    2015-09-30

    Similar to regression, many measures to detect influential data points in discriminant analysis have been developed. Many follow similar principles as the diagnostic measures used in linear regression in the context of discriminant analysis. Here we focus on the impact on the predicted classification posterior probability when a data point is omitted. The new method is intuitive and easily interpretative compared to existing methods. We also propose a graphical display to show the individual movement of the posterior probability of other data points when a specific data point is omitted. This enables the summaries to capture the overall pattern ofmore » the change.« less

  16. Sensitivity Analysis and Optimal Control of Anthroponotic Cutaneous Leishmania

    PubMed Central

    Zamir, Muhammad; Zaman, Gul; Alshomrani, Ali Saleh

    2016-01-01

    This paper is focused on the transmission dynamics and optimal control of Anthroponotic Cutaneous Leishmania. The threshold condition R0 for initial transmission of infection is obtained by next generation method. Biological sense of the threshold condition is investigated and discussed in detail. The sensitivity analysis of the reproduction number is presented and the most sensitive parameters are high lighted. On the basis of sensitivity analysis, some control strategies are introduced in the model. These strategies positively reduce the effect of the parameters with high sensitivity indices, on the initial transmission. Finally, an optimal control strategy is presented by taking into account the cost associated with control strategies. It is also shown that an optimal control exists for the proposed control problem. The goal of optimal control problem is to minimize, the cost associated with control strategies and the chances of infectious humans, exposed humans and vector population to become infected. Numerical simulations are carried out with the help of Runge-Kutta fourth order procedure. PMID:27505634

  17. Least Squares Shadowing sensitivity analysis of chaotic limit cycle oscillations

    NASA Astrophysics Data System (ADS)

    Wang, Qiqi; Hu, Rui; Blonigan, Patrick

    2014-06-01

    The adjoint method, among other sensitivity analysis methods, can fail in chaotic dynamical systems. The result from these methods can be too large, often by orders of magnitude, when the result is the derivative of a long time averaged quantity. This failure is known to be caused by ill-conditioned initial value problems. This paper overcomes this failure by replacing the initial value problem with the well-conditioned "least squares shadowing (LSS) problem". The LSS problem is then linearized in our sensitivity analysis algorithm, which computes a derivative that converges to the derivative of the infinitely long time average. We demonstrate our algorithm in several dynamical systems exhibiting both periodic and chaotic oscillations.

  18. Control of a mechanical aeration process via topological sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Abdelwahed, M.; Hassine, M.; Masmoudi, M.

    2009-06-01

    The topological sensitivity analysis method gives the variation of a criterion with respect to the creation of a small hole in the domain. In this paper, we use this method to control the mechanical aeration process in eutrophic lakes. A simplified model based on incompressible Navier-Stokes equations is used, only considering the liquid phase, which is the dominant one. The injected air is taken into account through local boundary conditions for the velocity, on the injector holes. A 3D numerical simulation of the aeration effects is proposed using a mixed finite element method. In order to generate the best motion in the fluid for aeration purposes, the optimization of the injector location is considered. The main idea is to carry out topological sensitivity analysis with respect to the insertion of an injector. Finally, a topological optimization algorithm is proposed and some numerical results, showing the efficiency of our approach, are presented.

  19. Sensitivity analysis techniques for models of human behavior.

    SciTech Connect

    Bier, Asmeret Brooke

    2010-09-01

    Human and social modeling has emerged as an important research area at Sandia National Laboratories due to its potential to improve national defense-related decision-making in the presence of uncertainty. To learn about which sensitivity analysis techniques are most suitable for models of human behavior, different promising methods were applied to an example model, tested, and compared. The example model simulates cognitive, behavioral, and social processes and interactions, and involves substantial nonlinearity, uncertainty, and variability. Results showed that some sensitivity analysis methods create similar results, and can thus be considered redundant. However, other methods, such as global methods that consider interactions between inputs, can generate insight not gained from traditional methods.

  20. Global sensitivity analysis for DSMC simulations of hypersonic shocks

    NASA Astrophysics Data System (ADS)

    Strand, James S.; Goldstein, David B.

    2013-08-01

    Two global, Monte Carlo based sensitivity analyses were performed to determine which reaction rates most affect the results of Direct Simulation Monte Carlo (DSMC) simulations for a hypersonic shock in five-species air. The DSMC code was written and optimized with shock tube simulations in mind, and includes modifications to allow for the efficient simulation of a 1D hypersonic shock. The TCE model is used to convert Arrhenius-form reaction rate constants into reaction cross-sections, after modification to allow accurate modeling of reactions with arbitrarily large rates relative to the VHS collision rate. The square of the Pearson correlation coefficient was used as the measure for sensitivity in the first of the analyses, and the mutual information was used as the measure in the second. The quantity of interest (QoI) for these analyses was the NO density profile across a 1D shock at ˜8000 m/s (M∞ ≈ 23). This vector QoI was broken into a set of scalar QoIs, each representing the density of NO at a specific point downstream of the shock, and sensitivities were calculated for each scalar QoI based on both measures of sensitivity. Profiles of sensitivity vs. location downstream of the shock were then integrated to determine an overall sensitivity for each reaction. A weighting function was used in the integration in order to emphasize sensitivities in the region of greatest thermal and chemical non-equilibrium. Both sensitivity analysis methods agree on the six reactions which most strongly affect the density of NO. These six reactions are the N2 dissociation reaction N2 + N ⇄ 3N, the O2 dissociation reaction O2 + O ⇄ 3O, the NO dissociation reactions NO + N ⇄ 2N + O and NO + O ⇄ N + 2O, and the exchange reactions N2 + O ⇄ NO + N and NO + O ⇄ O2 + N. This analysis lays the groundwork for the application of Bayesian statistical methods for the calibration of parameters relevant to modeling a hypersonic shock layer with the DSMC method.

  1. Nano-morphology induced additional surface plasmon resonance enhancement of SERS sensitivity in Ag/GaN nanowall network

    NASA Astrophysics Data System (ADS)

    Sharvani, S.; Upadhayaya, Kishor; Kumari, Gayatri; Narayana, Chandrabhas; Shivaprasad, S. M.

    2015-11-01

    The GaN nanowall network, formed by opening the screw dislocations by kinetically controlled MBE growth, possesses a large surface and high conductivity. Sharp apexed nanowalls show higher surface electron concentration in the band-tail states, in comparison to blunt apexed nanowalls. Uncapped silver nanoparticles are vapor deposited on the blunt and sharp GaN nanowall networks to study the morphological dependence of band-edge plasmon-coupling. Surface enhanced Raman spectroscopy studies performed with a rhodamine 6G analyte on these two configurations clearly show that the sharp nanowall morphology with smaller Ag nanoparticles shows higher enhancement of the Raman signal. A very large enhancement factor of 2.8 × 107 and a very low limit of detection of 10-10 M is observed, which is attributed to the surface plasmon resonance owing to the high surface electron concentration on the GaN nanowall in addition to that of the Ag nanoparticles. The significantly higher sensitivity with same-sized Ag nanoparticles confirms the unconventional role of morphology-dependent surface charge carrier concentration of GaN nanowalls in the enhancement of Raman signals.

  2. Nano-morphology induced additional surface plasmon resonance enhancement of SERS sensitivity in Ag/GaN nanowall network.

    PubMed

    Sharvani, S; Upadhayaya, Kishor; Kumari, Gayatri; Narayana, Chandrabhas; Shivaprasad, S M

    2015-11-20

    The GaN nanowall network, formed by opening the screw dislocations by kinetically controlled MBE growth, possesses a large surface and high conductivity. Sharp apexed nanowalls show higher surface electron concentration in the band-tail states, in comparison to blunt apexed nanowalls. Uncapped silver nanoparticles are vapor deposited on the blunt and sharp GaN nanowall networks to study the morphological dependence of band-edge plasmon-coupling. Surface enhanced Raman spectroscopy studies performed with a rhodamine 6G analyte on these two configurations clearly show that the sharp nanowall morphology with smaller Ag nanoparticles shows higher enhancement of the Raman signal. A very large enhancement factor of 2.8 × 10(7) and a very low limit of detection of 10(-10) M is observed, which is attributed to the surface plasmon resonance owing to the high surface electron concentration on the GaN nanowall in addition to that of the Ag nanoparticles. The significantly higher sensitivity with same-sized Ag nanoparticles confirms the unconventional role of morphology-dependent surface charge carrier concentration of GaN nanowalls in the enhancement of Raman signals. PMID:26502004

  3. Recent advances in steady compressible aerodynamic sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Taylor, Arthur C., III; Newman, Perry A.; Hou, Gene J.-W.; Jones, Henry E.

    1992-01-01

    Sensitivity analysis methods are classified as belonging to either of the two broad categories: the discrete (quasi-analytical) approach and the continuous approach. The two approaches differ by the order in which discretization and differentiation of the governing equations and boundary conditions is undertaken. The discussion focuses on the discrete approach. Basic equations are presented, and the major difficulties are reviewed in some detail, as are the proposed solutions. Recent research activity concerned with the continuous approach is also discussed.

  4. Sensitivity Analysis of Inverse Methods in Eddy Current Pit Characterization

    NASA Astrophysics Data System (ADS)

    Aldrin, John C.; Sabbagh, Harold A.; Murphy, R. Kim; Sabbagh, Elias H.; Knopp, Jeremy S.

    2010-02-01

    A sensitivity analysis was performed for a pit characterization problem to quantify the impact of potential sources for variation on the performance of inverse methods. Certain data processing steps, including careful feature extraction, background clutter removal and compensation for variation in the scan step size through the tubing, were found to be critical to achieve good estimates of the pit depth and diameter. Variance studied in model probe dimensions did not adversely affect performance.

  5. Global Sensitivity Analysis of Environmental Models: Convergence, Robustness and Accuracy Analysis

    NASA Astrophysics Data System (ADS)

    Sarrazin, F.; Pianosi, F.; Hartmann, A. J.; Wagener, T.

    2014-12-01

    Sensitivity analysis aims to characterize the impact that changes in model input factors (e.g. the parameters) have on the model output (e.g. simulated streamflow). It is a valuable diagnostic tool for model understanding and for model improvement, it enhances calibration efficiency, and it supports uncertainty and scenario analysis. It is of particular interest for environmental models because they are often complex, non-linear, non-monotonic and exhibit strong interactions between their parameters. However, sensitivity analysis has to be carefully implemented to produce reliable results at moderate computational cost. For example, sample size can have a strong impact on the results and has to be carefully chosen. Yet, there is little guidance available for this step in environmental modelling. The objective of the present study is to provide guidelines for a robust sensitivity analysis, in order to support modellers in making appropriate choices for its implementation and in interpreting its outcome. We considered hydrological models with increasing level of complexity. We tested four sensitivity analysis methods, Regional Sensitivity Analysis, Method of Morris, a density-based (PAWN) and a variance-based (Sobol) method. The convergence and variability of sensitivity indices were investigated. We used bootstrapping to assess and improve the robustness of sensitivity indices even for limited sample sizes. Finally, we propose a quantitative validation approach for sensitivity analysis based on the Kolmogorov-Smirnov statistics.

  6. Sensitivity Analysis of Launch Vehicle Debris Risk Model

    NASA Technical Reports Server (NTRS)

    Gee, Ken; Lawrence, Scott L.

    2010-01-01

    As part of an analysis of the loss of crew risk associated with an ascent abort system for a manned launch vehicle, a model was developed to predict the impact risk of the debris resulting from an explosion of the launch vehicle on the crew module. The model consisted of a debris catalog describing the number, size and imparted velocity of each piece of debris, a method to compute the trajectories of the debris and a method to calculate the impact risk given the abort trajectory of the crew module. The model provided a point estimate of the strike probability as a function of the debris catalog, the time of abort and the delay time between the abort and destruction of the launch vehicle. A study was conducted to determine the sensitivity of the strike probability to the various model input parameters and to develop a response surface model for use in the sensitivity analysis of the overall ascent abort risk model. The results of the sensitivity analysis and the response surface model are presented in this paper.

  7. Sensitivity analysis of coexistence in ecological communities: theory and application.

    PubMed

    Barabás, György; Pásztor, Liz; Meszéna, Géza; Ostling, Annette

    2014-12-01

    Sensitivity analysis, the study of how ecological variables of interest respond to changes in external conditions, is a theoretically well-developed and widely applied approach in population ecology. Though the application of sensitivity analysis to predicting the response of species-rich communities to disturbances also has a long history, derivation of a mathematical framework for understanding the factors leading to robust coexistence has only been a recent undertaking. Here we suggest that this development opens up a new perspective, providing advances ranging from the applied to the theoretical. First, it yields a framework to be applied in specific cases for assessing the extinction risk of community modules in the face of environmental change. Second, it can be used to determine trait combinations allowing for coexistence that is robust to environmental variation, and limits to diversity in the presence of environmental variation, for specific community types. Third, it offers general insights into the nature of communities that are robust to environmental variation. We apply recent community-level extensions of mathematical sensitivity analysis to example models for illustration. We discuss the advantages and limitations of the method, and some of the empirical questions the theoretical framework could help answer. PMID:25252135

  8. Sensitivity analysis and approximation methods for general eigenvalue problems

    NASA Technical Reports Server (NTRS)

    Murthy, D. V.; Haftka, R. T.

    1986-01-01

    Optimization of dynamic systems involving complex non-hermitian matrices is often computationally expensive. Major contributors to the computational expense are the sensitivity analysis and reanalysis of a modified design. The present work seeks to alleviate this computational burden by identifying efficient sensitivity analysis and approximate reanalysis methods. For the algebraic eigenvalue problem involving non-hermitian matrices, algorithms for sensitivity analysis and approximate reanalysis are classified, compared and evaluated for efficiency and accuracy. Proper eigenvector normalization is discussed. An improved method for calculating derivatives of eigenvectors is proposed based on a more rational normalization condition and taking advantage of matrix sparsity. Important numerical aspects of this method are also discussed. To alleviate the problem of reanalysis, various approximation methods for eigenvalues are proposed and evaluated. Linear and quadratic approximations are based directly on the Taylor series. Several approximation methods are developed based on the generalized Rayleigh quotient for the eigenvalue problem. Approximation methods based on trace theorem give high accuracy without needing any derivatives. Operation counts for the computation of the approximations are given. General recommendations are made for the selection of appropriate approximation technique as a function of the matrix size, number of design variables, number of eigenvalues of interest and the number of design points at which approximation is sought.

  9. Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy

    PubMed Central

    Crameri, Aureliano; von Wyl, Agnes; Koemeda, Margit; Schulthess, Peter; Tschuschke, Volker

    2015-01-01

    The importance of preventing and treating incomplete data in effectiveness studies is nowadays emphasized. However, most of the publications focus on randomized clinical trials (RCT). One flexible technique for statistical inference with missing data is multiple imputation (MI). Since methods such as MI rely on the assumption of missing data being at random (MAR), a sensitivity analysis for testing the robustness against departures from this assumption is required. In this paper we present a sensitivity analysis technique based on posterior predictive checking, which takes into consideration the concept of clinical significance used in the evaluation of intra-individual changes. We demonstrate the possibilities this technique can offer with the example of irregular longitudinal data collected with the Outcome Questionnaire-45 (OQ-45) and the Helping Alliance Questionnaire (HAQ) in a sample of 260 outpatients. The sensitivity analysis can be used to (1) quantify the degree of bias introduced by missing not at random data (MNAR) in a worst reasonable case scenario, (2) compare the performance of different analysis methods for dealing with missing data, or (3) detect the influence of possible violations to the model assumptions (e.g., lack of normality). Moreover, our analysis showed that ratings from the patient's and therapist's version of the HAQ could significantly improve the predictive value of the routine outcome monitoring based on the OQ-45. Since analysis dropouts always occur, repeated measurements with the OQ-45 and the HAQ analyzed with MI are useful to improve the accuracy of outcome estimates in quality assurance assessments and non-randomized effectiveness studies in the field of outpatient psychotherapy. PMID:26283989

  10. Probabilistic constrained load flow based on sensitivity analysis

    SciTech Connect

    Karakatsanis, T.S.; Hatziargyriou, N.D. )

    1994-11-01

    This paper presents a method for network constrained setting of control variables based on probabilistic load flow analysis. The method determines operating constraint violations for a whole planning period together with the probability of each violation. An iterative algorithm is subsequently employed providing adjustments of the control variables based on sensitivity analysis of the constrained variables with respect to the control variables. The method is applied to the IEEE 14 busbar system and to a realistic model of the Hellenic Interconnected system indicating its suitability for short-term operational planning applications.

  11. Sensitivity of Forecast Skill to Different Objective Analysis Schemes

    NASA Technical Reports Server (NTRS)

    Baker, W. E.

    1979-01-01

    Numerical weather forecasts are characterized by rapidly declining skill in the first 48 to 72 h. Recent estimates of the sources of forecast error indicate that the inaccurate specification of the initial conditions contributes substantially to this error. The sensitivity of the forecast skill to the initial conditions is examined by comparing a set of real-data experiments whose initial data were obtained with two different analysis schemes. Results are presented to emphasize the importance of the objective analysis techniques used in the assimilation of observational data.

  12. Sensitivity Analysis and Validation for Numerical Simulation of Water Infiltration into Unsaturated Soil.

    PubMed

    Goh, Eng Giap; Noborio, Kosuke

    2015-01-01

    A FORTRAN code for liquid water flow in unsaturated soil under the isothermal condition was developed to simulate water infiltration into Yolo light clay. The governing equation, that is, Richards' equation, was approximated by the finite-difference method. A normalized sensitivity coefficient was used in the sensitivity analysis of Richards' equation. Normalized sensitivity coefficient was calculated using one-at-a-time (OAT) method and elementary effects (EE) method based on hydraulic functions for matric suction and hydraulic conductivity. Results from EE method provided additional insight into model input parameters, such as input parameter linearity and oscillating sign effect. Boundary volumetric water content (θ L (upper bound)) and saturated volumetric water content (θ s ) were consistently found to be the most sensitive parameters corresponding to positive and negative relations, as given by the hydraulic functions. In addition, although initial volumetric water content (θ L (initial cond)) and time-step size (Δt), respectively, possessed a great amount of sensitivity coefficient and uncertainty value, they did not exhibit significant influence on model output as demonstrated by spatial discretization size (Δz). The input multiplication of parameters sensitivity coefficient and uncertainty value was found to affect the outcome of model simulation, in which parameter with the highest value was found to be Δz. PMID:27347550

  13. Sensitivity Analysis and Validation for Numerical Simulation of Water Infiltration into Unsaturated Soil

    PubMed Central

    Goh, Eng Giap

    2015-01-01

    A FORTRAN code for liquid water flow in unsaturated soil under the isothermal condition was developed to simulate water infiltration into Yolo light clay. The governing equation, that is, Richards' equation, was approximated by the finite-difference method. A normalized sensitivity coefficient was used in the sensitivity analysis of Richards' equation. Normalized sensitivity coefficient was calculated using one-at-a-time (OAT) method and elementary effects (EE) method based on hydraulic functions for matric suction and hydraulic conductivity. Results from EE method provided additional insight into model input parameters, such as input parameter linearity and oscillating sign effect. Boundary volumetric water content (θL (upper bound)) and saturated volumetric water content (θs) were consistently found to be the most sensitive parameters corresponding to positive and negative relations, as given by the hydraulic functions. In addition, although initial volumetric water content (θL (initial cond)) and time-step size (Δt), respectively, possessed a great amount of sensitivity coefficient and uncertainty value, they did not exhibit significant influence on model output as demonstrated by spatial discretization size (Δz). The input multiplication of parameters sensitivity coefficient and uncertainty value was found to affect the outcome of model simulation, in which parameter with the highest value was found to be Δz. PMID:27347550

  14. Sensitivity analysis of fine sediment models using heterogeneous data

    NASA Astrophysics Data System (ADS)

    Kamel, A. M. Yousif; Bhattacharya, B.; El Serafy, G. Y.; van Kessel, T.; Solomatine, D. P.

    2012-04-01

    Sediments play an important role in many aquatic systems. Their transportation and deposition has significant implication on morphology, navigability and water quality. Understanding the dynamics of sediment transportation in time and space is therefore important in drawing interventions and making management decisions. This research is related to the fine sediment dynamics in the Dutch coastal zone, which is subject to human interference through constructions, fishing, navigation, sand mining, etc. These activities do affect the natural flow of sediments and sometimes lead to environmental concerns or affect the siltation rates in harbours and fairways. Numerical models are widely used in studying fine sediment processes. Accuracy of numerical models depends upon the estimation of model parameters through calibration. Studying the model uncertainty related to these parameters is important in improving the spatio-temporal prediction of suspended particulate matter (SPM) concentrations, and determining the limits of their accuracy. This research deals with the analysis of a 3D numerical model of North Sea covering the Dutch coast using the Delft3D modelling tool (developed at Deltares, The Netherlands). The methodology in this research was divided into three main phases. The first phase focused on analysing the performance of the numerical model in simulating SPM concentrations near the Dutch coast by comparing the model predictions with SPM concentrations estimated from NASA's MODIS sensors at different time scales. The second phase focused on carrying out a sensitivity analysis of model parameters. Four model parameters were identified for the uncertainty and sensitivity analysis: the sedimentation velocity, the critical shear stress above which re-suspension occurs, the shields shear stress for re-suspension pick-up, and the re-suspension pick-up factor. By adopting different values of these parameters the numerical model was run and a comparison between the

  15. Analysis of frequency characteristics and sensitivity of compliant mechanisms

    NASA Astrophysics Data System (ADS)

    Liu, Shanzeng; Dai, Jiansheng; Li, Aimin; Sun, Zhaopeng; Feng, Shizhe; Cao, Guohua

    2016-03-01

    Based on a modified pseudo-rigid-body model, the frequency characteristics and sensitivity of the large-deformation compliant mechanism are studied. Firstly, the pseudo-rigid-body model under the static and kinetic conditions is modified to enable the modified pseudo-rigid-body model to be more suitable for the dynamic analysis of the compliant mechanism. Subsequently, based on the modified pseudo-rigid-body model, the dynamic equations of the ordinary compliant four-bar mechanism are established using the analytical mechanics. Finally, in combination with the finite element analysis software ANSYS, the frequency characteristics and sensitivity of the compliant mechanism are analyzed by taking the compliant parallel-guiding mechanism and the compliant bistable mechanism as examples. From the simulation results, the dynamic characteristics of compliant mechanism are relatively sensitive to the structure size, section parameter, and characteristic parameter of material on mechanisms. The results could provide great theoretical significance and application values for the structural optimization of compliant mechanisms, the improvement of their dynamic properties and the expansion of their application range.

  16. Optimizing human activity patterns using global sensitivity analysis

    PubMed Central

    Hickmann, Kyle S.; Mniszewski, Susan M.; Del Valle, Sara Y.; Hyman, James M.

    2014-01-01

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule’s regularity for a population. We show how to tune an activity’s regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimization problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. We use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations. PMID:25580080

  17. Optimizing human activity patterns using global sensitivity analysis

    SciTech Connect

    Fairchild, Geoffrey; Hickmann, Kyle S.; Mniszewski, Susan M.; Del Valle, Sara Y.; Hyman, James M.

    2013-12-10

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule’s regularity for a population. We show how to tune an activity’s regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimization problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. Here we use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Finally, though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations.

  18. Sensitivity-analysis techniques: self-teaching curriculum

    SciTech Connect

    Iman, R.L.; Conover, W.J.

    1982-06-01

    This self teaching curriculum on sensitivity analysis techniques consists of three parts: (1) Use of the Latin Hypercube Sampling Program (Iman, Davenport and Ziegler, Latin Hypercube Sampling (Program User's Guide), SAND79-1473, January 1980); (2) Use of the Stepwise Regression Program (Iman, et al., Stepwise Regression with PRESS and Rank Regression (Program User's Guide) SAND79-1472, January 1980); and (3) Application of the procedures to sensitivity and uncertainty analyses of the groundwater transport model MWFT/DVM (Campbell, Iman and Reeves, Risk Methodology for Geologic Disposal of Radioactive Waste - Transport Model Sensitivity Analysis; SAND80-0644, NUREG/CR-1377, June 1980: Campbell, Longsine, and Reeves, The Distributed Velocity Method of Solving the Convective-Dispersion Equation, SAND80-0717, NUREG/CR-1376, July 1980). This curriculum is one in a series developed by Sandia National Laboratories for transfer of the capability to use the technology developed under the NRC funded High Level Waste Methodology Development Program.

  19. Optimizing human activity patterns using global sensitivity analysis

    DOE PAGESBeta

    Fairchild, Geoffrey; Hickmann, Kyle S.; Mniszewski, Susan M.; Del Valle, Sara Y.; Hyman, James M.

    2013-12-10

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule’s regularity for a population. We show how to tune an activity’s regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimizationmore » problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. Here we use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Finally, though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations.« less

  20. Hyperspectral data analysis procedures with reduced sensitivity to noise

    NASA Technical Reports Server (NTRS)

    Landgrebe, David A.

    1993-01-01

    Multispectral sensor systems have become steadily improved over the years in their ability to deliver increased spectral detail. With the advent of hyperspectral sensors, including imaging spectrometers, this technology is in the process of taking a large leap forward, thus providing the possibility of enabling delivery of much more detailed information. However, this direction of development has drawn even more attention to the matter of noise and other deleterious effects in the data, because reducing the fundamental limitations of spectral detail on information collection raises the limitations presented by noise to even greater importance. Much current effort in remote sensing research is thus being devoted to adjusting the data to mitigate the effects of noise and other deleterious effects. A parallel approach to the problem is to look for analysis approaches and procedures which have reduced sensitivity to such effects. We discuss some of the fundamental principles which define analysis algorithm characteristics providing such reduced sensitivity. One such analysis procedure including an example analysis of a data set is described, illustrating this effect.

  1. Local sensitivity analysis for compositional data with application to soil texture in hydrologic modelling

    NASA Astrophysics Data System (ADS)

    Loosvelt, L.; Vernieuwe, H.; Pauwels, V. R. N.; De Baets, B.; Verhoest, N. E. C.

    2012-07-01

    Compositional data, such as soil texture, are hard to deal with in the geosciences as standard statistical methods are often inappropriate to analyse this type of data. Especially in sensitivity analysis, the closed character of the data is often ignored. To that end, we developed a method to assess the local sensitivity of a model output w.r.t. a compositional model input. We adapted the finite difference technique such that the different parts of the input are perturbed simultaneously while the closed character of the data is preserved. We applied this method to a hydrologic model and assessed the sensitivity of the simulated soil moisture content to local changes in soil texture. Based on a high number of model runs, in which the soil texture was varied across the entire texture triangle, we identified zones of high sensitivity in the texture triangle. In such zones, the model output uncertainty induced by the discrepancy between the scale of measurement and the scale of model application, is advised to be reduced through additional data collection. Furthermore, the sensitivity analysis provided more insight into the hydrologic model behaviour as it revealed how the model sensitivity is related to the shape of the soil moisture retention curve.

  2. Local sensitivity analysis for compositional data with application to soil texture in hydrologic modelling

    NASA Astrophysics Data System (ADS)

    Loosvelt, L.; Vernieuwe, H.; Pauwels, V. R. N.; De Baets, B.; Verhoest, N. E. C.

    2013-02-01

    Compositional data, such as soil texture, are hard to deal with in the geosciences as standard statistical methods are often inappropriate to analyse this type of data. Especially in sensitivity analysis, the closed character of the data is often ignored. To that end, we developed a method to assess the local sensitivity of a model output with resect to a compositional model input. We adapted the finite difference technique such that the different parts of the input are perturbed simultaneously while the closed character of the data is preserved. This method was applied to a hydrologic model and the sensitivity of the simulated soil moisture content to local changes in soil texture was assessed. Based on a high number of model runs, in which the soil texture was varied across the entire texture triangle, we identified zones of high sensitivity in the texture triangle. In such zones, the model output uncertainty induced by the discrepancy between the scale of measurement and the scale of model application, is advised to be reduced through additional data collection. Furthermore, the sensitivity analysis provided more insight into the hydrologic model behaviour as it revealed how the model sensitivity is related to the shape of the soil moistureretention curve.

  3. Sobol‧ sensitivity analysis of NAPL-contaminated aquifer remediation process based on multiple surrogates

    NASA Astrophysics Data System (ADS)

    Luo, Jiannan; Lu, Wenxi

    2014-06-01

    Sobol‧ sensitivity analyses based on different surrogates were performed on a trichloroethylene (TCE)-contaminated aquifer to assess the sensitivity of the design variables of remediation duration, surfactant concentration and injection rates at four wells to remediation efficiency First, the surrogate models of a multi-phase flow simulation model were constructed by applying radial basis function artificial neural network (RBFANN) and Kriging methods, and the two models were then compared. Based on the developed surrogate models, the Sobol‧ method was used to calculate the sensitivity indices of the design variables which affect the remediation efficiency. The coefficient of determination (R2) and the mean square error (MSE) of these two surrogate models demonstrated that both models had acceptable approximation accuracy, furthermore, the approximation accuracy of the Kriging model was slightly better than that of the RBFANN model. Sobol‧ sensitivity analysis results demonstrated that the remediation duration was the most important variable influencing remediation efficiency, followed by rates of injection at wells 1 and 3, while rates of injection at wells 2 and 4 and the surfactant concentration had negligible influence on remediation efficiency. In addition, high-order sensitivity indices were all smaller than 0.01, which indicates that interaction effects of these six factors were practically insignificant. The proposed Sobol‧ sensitivity analysis based on surrogate is an effective tool for calculating sensitivity indices, because it shows the relative contribution of the design variables (individuals and interactions) to the output performance variability with a limited number of runs of a computationally expensive simulation model. The sensitivity analysis results lay a foundation for the optimal groundwater remediation process optimization.

  4. Treatment of body forces in boundary element design sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Saigal, Sunil; Kane, James H.; Aithal, R.; Cheng, Jizu

    1989-01-01

    The inclusion of body forces has received a good deal of attention in boundary element research. The consideration of such forces is essential in the desgin of high performance components such as fan and turbine disks in a gas turbine engine. Due to their critical performance requirements, optimal shapes are often desired for these components. The boundary element method (BEM) offers the possibility of being an efficient method for such iterative analysis as shape optimization. The implicit-differentiation of the boundary integral equations is performed to obtain the sensitivity equations. The body forces are accounted for by either the particular integrals for uniform body forces or by a surface integration for non-uniform body forces. The corresponding sensitivity equations for both these cases are presented. The validity of present formulations is established through a close agreement with exact analytical results.

  5. Sensitivity analysis for nonrandom dropout: a local influence approach.

    PubMed

    Verbeke, G; Molenberghs, G; Thijs, H; Lesaffre, E; Kenward, M G

    2001-03-01

    Diggle and Kenward (1994, Applied Statistics 43, 49-93) proposed a selection model for continuous longitudinal data subject to nonrandom dropout. It has provoked a large debate about the role for such models. The original enthusiasm was followed by skepticism about the strong but untestable assumptions on which this type of model invariably rests. Since then, the view has emerged that these models should ideally be made part of a sensitivity analysis. This paper presents a formal and flexible approach to such a sensitivity assessment based on local influence (Cook, 1986, Journal of the Royal Statistical Society, Series B 48, 133-169). The influence of perturbing a missing-at-random dropout model in the direction of nonrandom dropout is explored. The method is applied to data from a randomized experiment on the inhibition of testosterone production in rats. PMID:11252620

  6. SENSITIVITY ANALYSIS OF A TPB DEGRADATION RATE MODEL

    SciTech Connect

    Crawford, C; Tommy Edwards, T; Bill Wilmarth, B

    2006-08-01

    A tetraphenylborate (TPB) degradation model for use in aggregating Tank 48 material in Tank 50 is developed in this report. The influential factors for this model are listed as the headings in the table below. A sensitivity study of the predictions of the model over intervals of values for the influential factors affecting the model was conducted. These intervals bound the levels of these factors expected during Tank 50 aggregations. The results from the sensitivity analysis were used to identify settings for the influential factors that yielded the largest predicted TPB degradation rate. Thus, these factor settings are considered as those that yield the ''worst-case'' scenario for TPB degradation rate for Tank 50 aggregation, and, as such they would define the test conditions that should be studied in a waste qualification program whose dual purpose would be the investigation of the introduction of Tank 48 material for aggregation in Tank 50 and the bounding of TPB degradation rates for such aggregations.

  7. An easily implemented static condensation method for structural sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Gangadharan, S. N.; Haftka, R. T.; Nikolaidis, E.

    1990-01-01

    A black-box approach to static condensation for sensitivity analysis is presented with illustrative examples of a cube and a car structure. The sensitivity of the structural response with respect to joint stiffness parameter is calculated using the direct method, forward-difference, and central-difference schemes. The efficiency of the various methods for identifying joint stiffness parameters from measured static deflections of these structures is compared. The results indicate that the use of static condensation can reduce computation times significantly and the black-box approach is only slightly less efficient than the standard implementation of static condensation. The ease of implementation of the black-box approach recommends it for use with general-purpose finite element codes that do not have a built-in facility for static condensation.

  8. Multiplexed analysis of chromosome conformation at vastly improved sensitivity

    PubMed Central

    Davies, James O.J.; Telenius, Jelena M.; McGowan, Simon; Roberts, Nigel A.; Taylor, Stephen; Higgs, Douglas R.; Hughes, Jim R.

    2015-01-01

    Since methods for analysing chromosome conformation in mammalian cells are either low resolution or low throughput and are technically challenging they are not widely used outside of specialised laboratories. We have re-designed the Capture-C method producing a new approach, called next generation (NG) Capture-C. This produces unprecedented levels of sensitivity and reproducibility and can be used to analyse many genetic loci and samples simultaneously. Importantly, high-resolution data can be produced on as few as 100,000 cells and SNPs can be used to generate allele specific tracks. The method is straightforward to perform and should therefore greatly facilitate the task of linking SNPs identified by genome wide association studies with the genes they influence. The complete and detailed protocol presented here, with new publicly available tools for library design and data analysis, will allow most laboratories to analyse chromatin conformation at levels of sensitivity and throughput that were previously impossible. PMID:26595209

  9. Sensitivity Analysis of Hardwired Parameters in GALE Codes

    SciTech Connect

    Geelhood, Kenneth J.; Mitchell, Mark R.; Droppo, James G.

    2008-12-01

    The U.S. Nuclear Regulatory Commission asked Pacific Northwest National Laboratory to provide a data-gathering plan for updating the hardwired data tables and parameters of the Gaseous and Liquid Effluents (GALE) codes to reflect current nuclear reactor performance. This would enable the GALE codes to make more accurate predictions about the normal radioactive release source term applicable to currently operating reactors and to the cohort of reactors planned for construction in the next few years. A sensitivity analysis was conducted to define the importance of hardwired parameters in terms of each parameter’s effect on the emission rate of the nuclides that are most important in computing potential exposures. The results of this study were used to compile a list of parameters that should be updated based on the sensitivity of these parameters to outputs of interest.

  10. Sensitivity analysis for dynamic systems with time-lags

    NASA Astrophysics Data System (ADS)

    Rihan, Fathalla A.

    2003-02-01

    Many problems in bioscience for which observations are reported in the literature can be modelled by suitable functional differential equations incorporating time-lags (other terminology: delays) or memory effects, parameterized by scientifically meaningful constant parameters p or/and variable parameters (for example, control functions) u(t). It is often desirable to have information about the effect on the solution of the dynamic system of perturbing the initial data, control functions, time-lags and other parameters appearing in the model. The main purpose of this paper is to derive a general theory for sensitivity analysis of mathematical models that contain time-lags. In this paper, we use adjoint equations and direct methods to estimate the sensitivity functions when the parameters appearing in the model are not only constants but also variables of time. To illustrate the results, the methodology is applied numerically to an example of a delay differential model.

  11. Simulation of the global contrail radiative forcing: A sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Yi, Bingqi; Yang, Ping; Liou, Kuo-Nan; Minnis, Patrick; Penner, Joyce E.

    2012-12-01

    The contrail radiative forcing induced by human aviation activity is one of the most uncertain contributions to climate forcing. An accurate estimation of global contrail radiative forcing is imperative, and the modeling approach is an effective and prominent method to investigate the sensitivity of contrail forcing to various potential factors. We use a simple offline model framework that is particularly useful for sensitivity studies. The most-up-to-date Community Atmospheric Model version 5 (CAM5) is employed to simulate the atmosphere and cloud conditions during the year 2006. With updated natural cirrus and additional contrail optical property parameterizations, the RRTMG Model (RRTM-GCM application) is used to simulate the global contrail radiative forcing. Global contrail coverage and optical depth derived from the literature for the year 2002 is used. The 2006 global annual averaged contrail net (shortwave + longwave) radiative forcing is estimated to be 11.3 mW m-2. Regional contrail radiative forcing over dense air traffic areas can be more than ten times stronger than the global average. A series of sensitivity tests are implemented and show that contrail particle effective size, contrail layer height, the model cloud overlap assumption, and contrail optical properties are among the most important factors. The difference between the contrail forcing under all and clear skies is also shown.

  12. Biosphere dose conversion Factor Importance and Sensitivity Analysis

    SciTech Connect

    M. Wasiolek

    2004-10-15

    This report presents importance and sensitivity analysis for the environmental radiation model for Yucca Mountain, Nevada (ERMYN). ERMYN is a biosphere model supporting the total system performance assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis concerns the output of the model, biosphere dose conversion factors (BDCFs) for the groundwater, and the volcanic ash exposure scenarios. It identifies important processes and parameters that influence the BDCF values and distributions, enhances understanding of the relative importance of the physical and environmental processes on the outcome of the biosphere model, includes a detailed pathway analysis for key radionuclides, and evaluates the appropriateness of selected parameter values that are not site-specific or have large uncertainty.

  13. Sensitivity Analysis of OECD Benchmark Tests in BISON

    SciTech Connect

    Swiler, Laura Painton; Gamble, Kyle; Schmidt, Rodney C.; Williamson, Richard

    2015-09-01

    This report summarizes a NEAMS (Nuclear Energy Advanced Modeling and Simulation) project focused on sensitivity analysis of a fuels performance benchmark problem. The benchmark problem was defined by the Uncertainty Analysis in Modeling working group of the Nuclear Science Committee, part of the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (OECD ). The benchmark problem involv ed steady - state behavior of a fuel pin in a Pressurized Water Reactor (PWR). The problem was created in the BISON Fuels Performance code. Dakota was used to generate and analyze 300 samples of 17 input parameters defining core boundary conditions, manuf acturing tolerances , and fuel properties. There were 24 responses of interest, including fuel centerline temperatures at a variety of locations and burnup levels, fission gas released, axial elongation of the fuel pin, etc. Pearson and Spearman correlatio n coefficients and Sobol' variance - based indices were used to perform the sensitivity analysis. This report summarizes the process and presents results from this study.

  14. Sensitivity analysis of the GNSS derived Victoria plate motion

    NASA Astrophysics Data System (ADS)

    Apolinário, João; Fernandes, Rui; Bos, Machiel

    2014-05-01

    Fernandes et al. (2013) estimated the angular velocity of the Victoria tectonic block from geodetic data (GNSS derived velocities) only.. GNSS observations are sparse in this region and it is therefore of the utmost importance to use the available data (5 sites) in the most optimal way. Unfortunately, the existing time-series were/are affected by missing data and offsets. In addition, some time-series were close to the considered minimal threshold value to compute one reliable velocity solution: 2.5-3.0 years. In this research, we focus on the sensitivity of the derived angular velocity to changes in the data (longer data-span for some stations) by extending the used data-span: Fernandes et al. (2013) used data until September 2011. We also investigate the effect of adding other stations to the solution, which is now possible since more stations became available in the region. In addition, we study if the conventional power-law plus white noise model is indeed the best stochastic model. In this respect, we apply different noise models using HECTOR (Bos et al. (2013), which can use different noise models and estimate offsets and seasonal signals simultaneously. The seasonal signal estimation is also other important parameter, since the time-series are rather short or have large data spans at some stations, which implies that the seasonal signals still can have some effect on the estimated trends as shown by Blewitt and Lavellee (2002) and Bos et al. (2010). We also quantify the magnitude of such differences in the estimation of the secular velocity and their effect in the derived angular velocity. Concerning the offsets, we investigate how they can, detected and undetected, influence the estimated plate motion. The time of offsets has been determined by visual inspection of the time-series. The influence of undetected offsets has been done by adding small synthetic random walk signals that are too small to be detected visually but might have an effect on the

  15. Rheological Models of Blood: Sensitivity Analysis and Benchmark Simulations

    NASA Astrophysics Data System (ADS)

    Szeliga, Danuta; Macioł, Piotr; Banas, Krzysztof; Kopernik, Magdalena; Pietrzyk, Maciej

    2010-06-01

    Modeling of blood flow with respect to rheological parameters of the blood is the objective of this paper. Casson type equation was selected as a blood model and the blood flow was analyzed based on Backward Facing Step benchmark. The simulations were performed using ADINA-CFD finite element code. Three output parameters were selected, which characterize the accuracy of flow simulation. Sensitivity analysis of the results with Morris Design method was performed to identify rheological parameters and the model output, which control the blood flow to significant extent. The paper is the part of the work on identification of parameters controlling process of clotting.

  16. Sensitivity analysis of discrete structural systems: A survey

    NASA Technical Reports Server (NTRS)

    Adelman, H. M.; Haftka, R. T.

    1984-01-01

    Methods for calculating sensitivity derivatives for discrete structural systems are surveyed, primarily covering literature published during the past two decades. Methods are described for calculating derivatives of static displacements and stresses, eigenvalues and eigenvectors, transient structural response, and derivatives of optimum structural designs with respect to problem parameters. The survey is focused on publications addressed to structural analysis, but also includes a number of methods developed in nonstructural fields such as electronics, controls, and physical chemistry which are directly applicable to structural problems. Most notable among the nonstructural-based methods are the adjoint variable technique from control theory, and the Green's function and FAST methods from physical chemistry.

  17. SENSITIVITY ANALYSIS FOR SALTSTONE DISPOSAL UNIT COLUMN DEGRADATION ANALYSES

    SciTech Connect

    Flach, G.

    2014-10-28

    PORFLOW related analyses supporting a Sensitivity Analysis for Saltstone Disposal Unit (SDU) column degradation were performed. Previous analyses, Flach and Taylor 2014, used a model in which the SDU columns degraded in a piecewise manner from the top and bottom simultaneously. The current analyses employs a model in which all pieces of the column degrade at the same time. Information was extracted from the analyses which may be useful in determining the distribution of Tc-99 in the various SDUs throughout time and in determining flow balances for the SDUs.

  18. Path-sensitive analysis for reducing rollback overheads

    SciTech Connect

    O'Brien, John K.P.; Wang, Kai-Ting Amy; Yamashita, Mark; Zhuang, Xiaotong

    2014-07-22

    A mechanism is provided for path-sensitive analysis for reducing rollback overheads. The mechanism receives, in a compiler, program code to be compiled to form compiled code. The mechanism divides the code into basic blocks. The mechanism then determines a restore register set for each of the one or more basic blocks to form one or more restore register sets. The mechanism then stores the one or more register sets such that responsive to a rollback during execution of the compiled code. A rollback routine identifies a restore register set from the one or more restore register sets and restores registers identified in the identified restore register set.

  19. A comparison of two sampling methods for global sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Tarantola, Stefano; Becker, William; Zeitz, Dirk

    2012-05-01

    We compare the convergence properties of two different quasi-random sampling designs - Sobol's quasi-Monte Carlo, and Latin supercube sampling in variance-based global sensitivity analysis. We use the non-monotonic V-function of Sobol' as base case-study, and compare the performance of both sampling strategies at increasing sample size and dimensionality against analytical values. The results indicate that in almost all cases investigated here, the Sobol' design performs better. This, coupled with the fact that effective Latin supercube sampling requires a priori knowledge of the interaction properties of the function, leads us to recommend Sobol' sampling in most practical cases.

  20. Sensitivity analysis of state-specific multireference perturbation theory

    NASA Astrophysics Data System (ADS)

    Szabados, Ágnes

    2011-05-01

    State-specific multireference perturbation theory (SS-MRPT) developed by Mukherjee et al. [Int. J. Mol. Sci. 3, 733 (2002)] is examined focusing on the dependence of the perturbed energy on the initial model space coefficients. It has been observed earlier, that non-physical kinks may appear on the potential energy surface obtained by SS-MRPT while related coupled-cluster methods may face convergence difficulties. Though exclusion or damping of the division by small coefficients may alleviate the problem, it is demonstrated here that the effect does not originate in an ill-defined division. It is shown that non-negligible model space coefficients may also be linked with the problem. Sensitivity analysis is suggested as a tool for detecting the coefficient responsible. By monitoring the singular values of sensitivity matrices, orders of magnitude increase is found in the largest value, in the vicinity of the problematic geometry point on the potential energy surface. The drastic increase of coefficient sensitivities is found to be linked with a degeneracy of the target root of the effective Hamiltonian. The nature of the one-electron orbitals has a profound influence on the picture: a rotation among active orbitals may screen or worsen the effect.

  1. A global sensitivity analysis of crop virtual water content

    NASA Astrophysics Data System (ADS)

    Tamea, S.; Tuninetti, M.; D'Odorico, P.; Laio, F.; Ridolfi, L.

    2015-12-01

    The concepts of virtual water and water footprint are becoming widely used in the scientific literature and they are proving their usefulness in a number of multidisciplinary contexts. With such growing interest a measure of data reliability (and uncertainty) is becoming pressing but, as of today, assessments of data sensitivity to model parameters, performed at the global scale, are not known. This contribution aims at filling this gap. Starting point of this study is the evaluation of the green and blue virtual water content (VWC) of four staple crops (i.e. wheat, rice, maize, and soybean) at a global high resolution scale. In each grid cell, the crop VWC is given by the ratio between the total crop evapotranspiration over the growing season and the crop actual yield, where evapotranspiration is determined with a detailed daily soil water balance and actual yield is estimated using country-based data, adjusted to account for spatial variability. The model provides estimates of the VWC at a 5x5 arc minutes and it improves on previous works by using the newest available data and including multi-cropping practices in the evaluation. The model is then used as the basis for a sensitivity analysis, in order to evaluate the role of model parameters in affecting the VWC and to understand how uncertainties in input data propagate and impact the VWC accounting. In each cell, small changes are exerted to one parameter at a time, and a sensitivity index is determined as the ratio between the relative change of VWC and the relative change of the input parameter with respect to its reference value. At the global scale, VWC is found to be most sensitive to the planting date, with a positive (direct) or negative (inverse) sensitivity index depending on the typical season of crop planting date. VWC is also markedly dependent on the length of the growing period, with an increase in length always producing an increase of VWC, but with higher spatial variability for rice than for

  2. Cisapride a green analytical reagent for rapid and sensitive determination of bromate in drinking water, bread and flour additives by oxidative coupling spectrophotometric methods

    NASA Astrophysics Data System (ADS)

    Al Okab, Riyad Ahmed

    2013-02-01

    Green analytical methods using Cisapride (CPE) as green analytical reagent was investigated in this work. Rapid, simple, and sensitive spectrophotometric methods for the determination of bromate in water sample, bread and flour additives were developed. The proposed methods based on the oxidative coupling between phenoxazine and Cisapride in the presence of bromate to form red colored product with max at 520 nm. Phenoxazine and Cisapride and its reaction products were found to be environmentally friendly under the optimum experimental condition. The method obeys beers law in concentration range 0.11-4.00 g ml-1 and molar absorptivity 1.41 × 104 L mol-1 cm-1. All variables have been optimized and the presented reaction sequences were applied to the analysis of bromate in water, bread and flour additive samples. The performance of these method was evaluated in terms of Student's t-test and variance ratio F-test to find out the significance of proposed methods over the reference method. The combination of pharmaceutical drugs reagents with low concentration create some unique green chemical analyses.

  3. Cisapride a green analytical reagent for rapid and sensitive determination of bromate in drinking water, bread and flour additives by oxidative coupling spectrophotometric methods.

    PubMed

    Al Okab, Riyad Ahmed

    2013-02-15

    Green analytical methods using Cisapride (CPE) as green analytical reagent was investigated in this work. Rapid, simple, and sensitive spectrophotometric methods for the determination of bromate in water sample, bread and flour additives were developed. The proposed methods based on the oxidative coupling between phenoxazine and Cisapride in the presence of bromate to form red colored product with max at 520 nm. Phenoxazine and Cisapride and its reaction products were found to be environmentally friendly under the optimum experimental condition. The method obeys beers law in concentration range 0.11-4.00 g ml(-1) and molar absorptivity 1.41 × 10(4) L mol(-1)cm(-1). All variables have been optimized and the presented reaction sequences were applied to the analysis of bromate in water, bread and flour additive samples. The performance of these method was evaluated in terms of Student's t-test and variance ratio F-test to find out the significance of proposed methods over the reference method. The combination of pharmaceutical drugs reagents with low concentration create some unique green chemical analyses. PMID:23261631

  4. Analysis of Transition-Sensitized Turbulent Transport Equations

    NASA Technical Reports Server (NTRS)

    Rumsey, Christopher L.; Thacker, William D.; Gatski, Thomas B.; Grosch, Chester E,

    2005-01-01

    The dynamics of an ensemble of linear disturbances in boundary-layer flows at various Reynolds numbers is studied through an analysis of the transport equations for the mean disturbance kinetic energy and energy dissipation rate. Effects of adverse and favorable pressure-gradients on the disturbance dynamics are also included in the analysis Unlike the fully turbulent regime where nonlinear phase scrambling of the fluctuations affects the flow field even in proximity to the wall, the early stage transition regime fluctuations studied here are influenced cross the boundary layer by the solid boundary. The dominating dynamics in the disturbance kinetic energy and dissipation rate equations are described. These results are then used to formulate transition-sensitized turbulent transport equations, which are solved in a two-step process and applied to zero-pressure-gradient flow over a flat plate. Computed results are in good agreement with experimental data.

  5. Comparative Analysis of State Fish Consumption Advisories Targeting Sensitive Populations

    PubMed Central

    Scherer, Alison C.; Tsuchiya, Ami; Younglove, Lisa R.; Burbacher, Thomas M.; Faustman, Elaine M.

    2008-01-01

    Objective Fish consumption advisories are issued to warn the public of possible toxicological threats from consuming certain fish species. Although developing fetuses and children are particularly susceptible to toxicants in fish, fish also contain valuable nutrients. Hence, formulating advice for sensitive populations poses challenges. We conducted a comparative analysis of advisory Web sites issued by states to assess health messages that sensitive populations might access. Data sources We evaluated state advisories accessed via the National Listing of Fish Advisories issued by the U.S. Environmental Protection Agency. Data extraction We created criteria to evaluate advisory attributes such as risk and benefit message clarity. Data synthesis All 48 state advisories issued at the time of this analysis targeted children, 90% (43) targeted pregnant women, and 58% (28) targeted women of childbearing age. Only six advisories addressed single contaminants, while the remainder based advice on 2–12 contaminants. Results revealed that advisories associated a dozen contaminants with specific adverse health effects. Beneficial health effects of any kind were specifically associated only with omega-3 fatty acids found in fish. Conclusions These findings highlight the complexity of assessing and communicating information about multiple contaminant exposure from fish consumption. Communication regarding potential health benefits conferred by specific fish nutrients was minimal and focused primarily on omega-3 fatty acids. This overview suggests some lessons learned and highlights a lack of both clarity and consistency in providing the breadth of information that sensitive populations such as pregnant women need to make public health decisions about fish consumption during pregnancy. PMID:19079708

  6. Global sensitivity analysis of the XUV-ABLATOR code

    NASA Astrophysics Data System (ADS)

    Nevrlý, Václav; Janku, Jaroslav; Dlabka, Jakub; Vašinek, Michal; Juha, Libor; Vyšín, Luděk.; Burian, Tomáš; Lančok, Ján.; Skřínský, Jan; Zelinger, Zdeněk.; Pira, Petr; Wild, Jan

    2013-05-01

    Availability of numerical model providing reliable estimation of the parameters of ablation processes induced by extreme ultraviolet laser pulses in the range of nanosecond and sub-picosecond timescales is highly desirable for recent experimental research as well as for practical purposes. Performance of the one-dimensional thermodynamic code (XUV-ABLATOR) in predicting the relationship of ablation rate and laser fluence is investigated for three reference materials: (i) silicon, (ii) fused silica and (iii) polymethyl methacrylate. The effect of pulse duration and different material properties on the model predictions is studied in the frame of this contribution for the conditions typical for two compact laser systems operating at 46.9 nm. Software implementation of the XUV-ABLATOR code including graphical user's interface and the set of tools for sensitivity analysis was developed. Global sensitivity analysis using high dimensional model representation in combination with quasi-random sampling was applied in order to identify the most critical input data as well as to explore the uncertainty range of model results.

  7. Multivariate Sensitivity Analysis of Time-of-Flight Sensor Fusion

    NASA Astrophysics Data System (ADS)

    Schwarz, Sebastian; Sjöström, Mårten; Olsson, Roger

    2014-09-01

    Obtaining three-dimensional scenery data is an essential task in computer vision, with diverse applications in various areas such as manufacturing and quality control, security and surveillance, or user interaction and entertainment. Dedicated Time-of-Flight sensors can provide detailed scenery depth in real-time and overcome short-comings of traditional stereo analysis. Nonetheless, they do not provide texture information and have limited spatial resolution. Therefore such sensors are typically combined with high resolution video sensors. Time-of-Flight Sensor Fusion is a highly active field of research. Over the recent years, there have been multiple proposals addressing important topics such as texture-guided depth upsampling and depth data denoising. In this article we take a step back and look at the underlying principles of ToF sensor fusion. We derive the ToF sensor fusion error model and evaluate its sensitivity to inaccuracies in camera calibration and depth measurements. In accordance with our findings, we propose certain courses of action to ensure high quality fusion results. With this multivariate sensitivity analysis of the ToF sensor fusion model, we provide an important guideline for designing, calibrating and running a sophisticated Time-of-Flight sensor fusion capture systems.

  8. Simple Sensitivity Analysis for Orion Guidance Navigation and Control

    NASA Technical Reports Server (NTRS)

    Pressburger, Tom; Hoelscher, Brian; Martin, Rodney; Sricharan, Kumar

    2013-01-01

    The performance of Orion flight software, especially its GNC software, is being analyzed by running Monte Carlo simulations of Orion spacecraft flights. The simulated performance is analyzed for conformance with flight requirements, expressed as performance constraints. Flight requirements include guidance (e.g. touchdown distance from target) and control (e.g., control saturation) as well as performance (e.g., heat load constraints). The Monte Carlo simulations disperse hundreds of simulation input variables, for everything from mass properties to date of launch. We describe in this paper a sensitivity analysis tool ("Critical Factors Tool" or CFT) developed to find the input variables or pairs of variables which by themselves significantly influence satisfaction of requirements or significantly affect key performance metrics (e.g., touchdown distance from target). Knowing these factors can inform robustness analysis, can inform where engineering resources are most needed, and could even affect operations. The contributions of this paper include the introduction of novel sensitivity measures, such as estimating success probability, and a technique for determining whether pairs of factors are interacting dependently or independently. The tool found that input variables such as moments, mass, thrust dispersions, and date of launch were found to be significant factors for success of various requirements. Examples are shown in this paper as well as a summary and physics discussion of EFT-1 driving factors that the tool found.

  9. Sensitivity Analysis of Offshore Wind Cost of Energy (Poster)

    SciTech Connect

    Dykes, K.; Ning, A.; Graf, P.; Scott, G.; Damiami, R.; Hand, M.; Meadows, R.; Musial, W.; Moriarty, P.; Veers, P.

    2012-10-01

    No matter the source, offshore wind energy plant cost estimates are significantly higher than for land-based projects. For instance, a National Renewable Energy Laboratory (NREL) review on the 2010 cost of wind energy found baseline cost estimates for onshore wind energy systems to be 71 dollars per megawatt-hour ($/MWh), versus 225 $/MWh for offshore systems. There are many ways that innovation can be used to reduce the high costs of offshore wind energy. However, the use of such innovation impacts the cost of energy because of the highly coupled nature of the system. For example, the deployment of multimegawatt turbines can reduce the number of turbines, thereby reducing the operation and maintenance (O&M) costs associated with vessel acquisition and use. On the other hand, larger turbines may require more specialized vessels and infrastructure to perform the same operations, which could result in higher costs. To better understand the full impact of a design decision on offshore wind energy system performance and cost, a system analysis approach is needed. In 2011-2012, NREL began development of a wind energy systems engineering software tool to support offshore wind energy system analysis. The tool combines engineering and cost models to represent an entire offshore wind energy plant and to perform system cost sensitivity analysis and optimization. Initial results were collected by applying the tool to conduct a sensitivity analysis on a baseline offshore wind energy system using 5-MW and 6-MW NREL reference turbines. Results included information on rotor diameter, hub height, power rating, and maximum allowable tip speeds.

  10. Adjoint design sensitivity analysis of reduced atomic systems using generalized Langevin equation for lattice structures

    SciTech Connect

    Kim, Min-Geun; Jang, Hong-Lae; Cho, Seonho

    2013-05-01

    An efficient adjoint design sensitivity analysis method is developed for reduced atomic systems. A reduced atomic system and the adjoint system are constructed in a locally confined region, utilizing generalized Langevin equation (GLE) for periodic lattice structures. Due to the translational symmetry of lattice structures, the size of time history kernel function that accounts for the boundary effects of the reduced atomic systems could be reduced to a single atom’s degrees of freedom. For the problems of highly nonlinear design variables, the finite difference method is impractical for its inefficiency and inaccuracy. However, the adjoint method is very efficient regardless of the number of design variables since one additional time integration is required for the adjoint GLE. Through numerical examples, the derived adjoint sensitivity turns out to be accurate and efficient through the comparison with finite difference sensitivity.

  11. Analysis and improvement of accuracy, sensitivity, and resolution of the coherent gradient sensing method.

    PubMed

    Dong, Xuelin; Zhang, Changxing; Feng, Xue; Duan, Zhiyin

    2016-06-10

    The coherent gradient sensing (CGS) method, one kind of shear interferometry sensitive to surface slope, has been applied to full-field curvature measuring for decades. However, its accuracy, sensitivity, and resolution have not been studied clearly. In this paper, we analyze the accuracy, sensitivity, and resolution for the CGS method based on the derivation of its working principle. The results show that the sensitivity is related to the grating pitch and distance, and the accuracy and resolution are determined by the wavelength of the laser beam and the diameter of the reflected beam. The sensitivity is proportional to the ratio of grating distance to its pitch, while the accuracy will decline as this ratio increases. In addition, we demonstrate that using phase gratings as the shearing element can improve the interferogram and enhance accuracy, sensitivity, and resolution. The curvature of a spherical reflector is measured by CGS with Ronchi gratings and phase gratings under different experimental parameters to illustrate this analysis. All of the results are quite helpful for CGS applications. PMID:27409035

  12. Radiolysis Model Sensitivity Analysis for a Used Fuel Storage Canister

    SciTech Connect

    Wittman, Richard S.

    2013-09-20

    This report fulfills the M3 milestone (M3FT-13PN0810027) to report on a radiolysis computer model analysis that estimates the generation of radiolytic products for a storage canister. The analysis considers radiolysis outside storage canister walls and within the canister fill gas over a possible 300-year lifetime. Previous work relied on estimates based directly on a water radiolysis G-value. This work also includes that effect with the addition of coupled kinetics for 111 reactions for 40 gas species to account for radiolytic-induced chemistry, which includes water recombination and reactions with air.

  13. A numerical analysis of a deep Mediterranean lee cyclone: sensitivity to mesoscale potential vorticity anomalies

    NASA Astrophysics Data System (ADS)

    Horvath, K.; Ivančan-Picek, B.

    2009-03-01

    A 12-15 November 2004 cyclone on the lee side of the Atlas Mountains and the related occurrence of severe bora along the eastern Adriatic coast are numerically analyzed using the MM5 mesoscale model. Motivated by the fact that sub-synoptic scales are more sensitive to initialization errors and dominate forecast error growth, this study is designed in order to assess the sensitivity of the mesoscale forecast to the intensity of mesoscale potential vorticity (PV) anomalies. Five sensitivity simulations are performed after subtracting the selected anomalies from the initial conditions, allowing for the analysis of the cyclone intensity and track, and additionally, the associated severe bora in the Adriatic. The results of the ensemble show that the cyclone is highly sensitive to the exact details of the upper-level dynamic forcing. The spread of cyclone intensities is the greatest in the mature phase of the cyclone lifecycle, due to different cyclone advection speeds towards the Mediterranean. However, the cyclone tracks diffluence appears to be the greatest during the cyclone movement out of the Atlas lee, prior to the mature stage of cyclone development, most likely due to the predominant upper-level steering control and its influence on the thermal anomaly creation in the mountain lee. Furthermore, it is quantitatively shown that the southern Adriatic bora is more sensitive to cyclone presence in the Mediterranean then bora in the northern Adriatic, due to unequal influence of the cyclone on the cross-mountain pressure gradient formation. The orographically induced pressure perturbation is strongly correlated with bora in the northern and to a lesser extent in the southern Adriatic, implying the existence of additional controlling mechanisms to bora in the southern part of the basin. In addition, it is shown that the bora intensity in the southern Adriatic is highly sensitive to the precise sub-synoptic pressure distribution in the cyclone itself, indicating a

  14. Parallel-vector design sensitivity analysis in structural dynamics

    NASA Technical Reports Server (NTRS)

    Zhang, Y.; Nguyen, D. T.

    1992-01-01

    This paper presents a parallel-vector algorithm for sensitivity calculations in linear structural dynamics. The proposed alternative formulation works efficiently with the reduced system of dynamic equations, since it eliminates the need for expensive and complicated based-vector derivatives, which are required in the conventional reduced system formulation. The relationship between the alternative formulation and the conventional reduced system formulation has been established, and it has been proven analytically that the two approaches are identical when all the mode shapes are included. This paper validates the proposed alternative algorithm through numerical experiments, where only a small number of mode shapes are used. In addition, a modified mode acceleration method is presented, thus not only the displacements but also the velocities and accelerations are shown to be improved.

  15. Global sensitivity analysis of the Indian monsoon during the Pleistocene

    NASA Astrophysics Data System (ADS)

    Araya-Melo, P. A.; Crucifix, M.; Bounceur, N.

    2015-01-01

    The sensitivity of the Indian monsoon to the full spectrum of climatic conditions experienced during the Pleistocene is estimated using the climate model HadCM3. The methodology follows a global sensitivity analysis based on the emulator approach of Oakley and O'Hagan (2004) implemented following a three-step strategy: (1) development of an experiment plan, designed to efficiently sample a five-dimensional input space spanning Pleistocene astronomical configurations (three parameters), CO2 concentration and a Northern Hemisphere glaciation index; (2) development, calibration and validation of an emulator of HadCM3 in order to estimate the response of the Indian monsoon over the full input space spanned by the experiment design; and (3) estimation and interpreting of sensitivity diagnostics, including sensitivity measures, in order to synthesise the relative importance of input factors on monsoon dynamics, estimate the phase of the monsoon intensity response with respect to that of insolation, and detect potential non-linear phenomena. By focusing on surface temperature, precipitation, mixed-layer depth and sea-surface temperature over the monsoon region during the summer season (June-July-August-September), we show that precession controls the response of four variables: continental temperature in phase with June to July insolation, high glaciation favouring a late-phase response, sea-surface temperature in phase with May insolation, continental precipitation in phase with July insolation, and mixed-layer depth in antiphase with the latter. CO2 variations control temperature variance with an amplitude similar to that of precession. The effect of glaciation is dominated by the albedo forcing, and its effect on precipitation competes with that of precession. Obliquity is a secondary effect, negligible on most variables except sea-surface temperature. It is also shown that orography forcing reduces the glacial cooling, and even has a positive effect on precipitation

  16. GPU-based Integration with Application in Sensitivity Analysis

    NASA Astrophysics Data System (ADS)

    Atanassov, Emanouil; Ivanovska, Sofiya; Karaivanova, Aneta; Slavov, Dimitar

    2010-05-01

    The presented work is an important part of the grid application MCSAES (Monte Carlo Sensitivity Analysis for Environmental Studies) which aim is to develop an efficient Grid implementation of a Monte Carlo based approach for sensitivity studies in the domains of Environmental modelling and Environmental security. The goal is to study the damaging effects that can be caused by high pollution levels (especially effects on human health), when the main modeling tool is the Danish Eulerian Model (DEM). Generally speaking, sensitivity analysis (SA) is the study of how the variation in the output of a mathematical model can be apportioned to, qualitatively or quantitatively, different sources of variation in the input of a model. One of the important classes of methods for Sensitivity Analysis are Monte Carlo based, first proposed by Sobol, and then developed by Saltelli and his group. In MCSAES the general Saltelli procedure has been adapted for SA of the Danish Eulerian model. In our case we consider as factors the constants determining the speeds of the chemical reactions in the DEM and as output a certain aggregated measure of the pollution. Sensitivity simulations lead to huge computational tasks (systems with up to 4 × 109 equations at every time-step, and the number of time-steps can be more than a million) which motivates its grid implementation. MCSAES grid implementation scheme includes two main tasks: (i) Grid implementation of the DEM, (ii) Grid implementation of the Monte Carlo integration. In this work we present our new developments in the integration part of the application. We have developed an algorithm for GPU-based generation of scrambled quasirandom sequences which can be combined with the CPU-based computations related to the SA. Owen first proposed scrambling of Sobol sequence through permutation in a manner that improves the convergence rates. Scrambling is necessary not only for error analysis but for parallel implementations. Good scrambling is

  17. Adjoint sensitivity analysis of hydrodynamic stability in cyclonic flows

    NASA Astrophysics Data System (ADS)

    Guzman Inigo, Juan; Juniper, Matthew

    2015-11-01

    Cyclonic separators are used in a variety of industries to efficiently separate mixtures of fluid and solid phases by means of centrifugal forces and gravity. In certain circumstances, the vortex core of cyclonic flows is known to precess due to the instability of the flow, which leads to performance reductions. We aim to characterize the unsteadiness using linear stability analysis of the Reynolds Averaged Navier-Stokes (RANS) equations in a global framework. The system of equations, including the turbulence model, is linearised to obtain an eigenvalue problem. Unstable modes corresponding to the dynamics of the large structures of the turbulent flow are extracted. The analysis shows that the most unstable mode is a helical motion which develops around the axis of the flow. This result is in good agreement with LES and experimental analysis, suggesting the validity of the approach. Finally, an adjoint-based sensitivity analysis is performed to determine the regions of the flow that, when altered, have most influence on the frequency and growth-rate of the unstable eigenvalues.

  18. Global sensitivity analysis of a 3D street canyon model—Part II: Application and physical insight using sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Benson, James; Ziehn, Tilo; Dixon, Nick S.; Tomlin, Alison S.

    In this work global sensitivity studies using Monte Carlo sampling and high dimensional model representations (HDMR) have been carried out on the k- ɛ closure computational fluid dynamic (CFD) model MISKAM, allowing detailed representation of the effects of changing input parameters on the model outputs. The scenario studied is that of a complex street canyon in the city of York, UK. The sensitivity of the turbulence and mean flow fields to the input parameters is detailed both at specific measurement points and in the associated canyon cross-section to aid comparison with field data. This analysis gives insight into how model parameters can influence the predicted outputs. It also shows the relative strength of each parameter in its influence. Four main input parameters are addressed. Three parameters are surface roughness lengths, determining the flow over a surface, and the fourth is the background wind direction. In order to determine the relative importance of each parameter, sensitivity indices are calculated for the canyon cross-section. The sensitivity of the flow structures in and above the canyon to each parameter is found to be very location dependant. In general, at a particular measurement point, it is the closest wall surface that is most influential on the model output. However, due to the complexity of the flow at different wind angles this is not always the case, for example when a re-circulating canyon flow pattern is present. The background wind direction is shown to be an important parameter as it determines the surface features encountered by the flow. The accuracy with which this is specified when modelling a full-scale situation is therefore an important consideration when considering model uncertainty. Overall, the uncertainty due to roughness lengths is small in comparison to the mean outputs, indicating that the model is well defined even with large ranges of input parameter uncertainty.

  19. Sensitivity analysis of channel-bend hydraulics influenced by vegetation

    NASA Astrophysics Data System (ADS)

    Bywater-Reyes, S.; Manners, R.; McDonald, R.; Wilcox, A. C.

    2015-12-01

    Alternating bars influence hydraulics by changing the force balance of channels as part of a morphodynamic feedback loop that dictates channel geometry. Pioneer woody riparian trees recruit on river bars and may steer flow, alter cross-stream and downstream force balances, and ultimately change channel morphology. Quantifying the influence of vegetation on stream hydraulics is difficult, and researchers increasingly rely on two-dimensional hydraulic models. In many cases, channel characteristics (channel drag and lateral eddy viscosity) and vegetation characteristics (density, frontal area, and drag coefficient) are uncertain. This study uses a beta version of FaSTMECH that models vegetation explicitly as a drag force to test the sensitivity of channel-bend hydraulics to riparian vegetation. We use a simplified, scale model of a meandering river with bars and conduct a global sensitivity analysis that ranks the influence of specified channel characteristics (channel drag and lateral eddy viscosity) against vegetation characteristics (density, frontal area, and drag coefficient) on cross-stream hydraulics. The primary influence on cross-stream velocity and shear stress is channel drag (i.e., bed roughness), followed by the near-equal influence of all vegetation parameters and lateral eddy viscosity. To test the implication of the sensitivity indices on bend hydraulics, we hold calibrated channel characteristics constant for a wandering gravel-bed river with bars (Bitterroot River, MT), and vary vegetation parameters on a bar. For a dense vegetation scenario, we find flow to be steered away from the bar, and velocity and shear stress to be reduced within the thalweg. This provides insight into how the morphodynamic evolution of vegetated bars differs from unvegetated bars.

  20. Global sensitivity analysis of the radiative transfer model

    NASA Astrophysics Data System (ADS)

    Neelam, Maheshwari; Mohanty, Binayak P.

    2015-04-01

    With the recently launched Soil Moisture Active Passive (SMAP) mission, it is very important to have a complete understanding of the radiative transfer model for better soil moisture retrievals and to direct future research and field campaigns in areas of necessity. Because natural systems show great variability and complexity with respect to soil, land cover, topography, precipitation, there exist large uncertainties and heterogeneities in model input factors. In this paper, we explore the possibility of using global sensitivity analysis (GSA) technique to study the influence of heterogeneity and uncertainties in model inputs on zero order radiative transfer (ZRT) model and to quantify interactions between parameters. GSA technique is based on decomposition of variance and can handle nonlinear and nonmonotonic functions. We direct our analyses toward growing agricultural fields of corn and soybean in two different regions, Iowa, USA (SMEX02) and Winnipeg, Canada (SMAPVEX12). We noticed that, there exists a spatio-temporal variation in parameter interactions under different soil moisture and vegetation conditions. Radiative Transfer Model (RTM) behaves more non-linearly in SMEX02 and linearly in SMAPVEX12, with average parameter interactions of 14% in SMEX02 and 5% in SMAPVEX12. Also, parameter interactions increased with vegetation water content (VWC) and roughness conditions. Interestingly, soil moisture shows an exponentially decreasing sensitivity function whereas parameters such as root mean square height (RMS height) and vegetation water content show increasing sensitivity with 0.05 v/v increase in soil moisture range. Overall, considering the SMAPVEX12 fields to be water rich environment (due to higher observed SM) and SMEX02 fields to be energy rich environment (due to lower SM and wide ranges of TSURF), our results indicate that first order as well as interactions between the parameters change with water and energy rich environments.

  1. Sensitivity Analysis of Differential-Algebraic Equations and Partial Differential Equations

    SciTech Connect

    Petzold, L; Cao, Y; Li, S; Serban, R

    2005-08-09

    Sensitivity analysis generates essential information for model development, design optimization, parameter estimation, optimal control, model reduction and experimental design. In this paper we describe the forward and adjoint methods for sensitivity analysis, and outline some of our recent work on theory, algorithms and software for sensitivity analysis of differential-algebraic equation (DAE) and time-dependent partial differential equation (PDE) systems.

  2. Neutron activation analysis; A sensitive test for trace elements

    SciTech Connect

    Hossain, T.Z. . Ward Lab.)

    1992-01-01

    This paper discusses neutron activation analysis (NAA), an extremely sensitive technique for determining the elemental constituents of an unknown specimen. Currently, there are some twenty-five moderate-power TRIGA reactors scattered across the United States (fourteen of them at universities), and one of their principal uses is for NAA. NAA is procedurally simple. A small amount of the material to be tested (typically between one and one hundred milligrams) is irradiated for a period that varies from a few minutes to several hours in a neutron flux of around 10{sup 12} neutrons per square centimeter per second. A tiny fraction of the nuclei present (about 10{sup {minus}8}) is transmuted by nuclear reactions into radioactive forms. Subsequently, the nuclei decay, and the energy and intensity of the gamma rays that they emit can be measured in a gamma-ray spectrometer.

  3. Apparatus and Method for Ultra-Sensitive trace Analysis

    SciTech Connect

    Lu, Zhengtian; Bailey, Kevin G.; Chen, Chun Yen; Li, Yimin; O'Connor, Thomas P.; Young, Linda

    2000-01-03

    An apparatus and method for conducting ultra-sensitive trace element and isotope analysis. The apparatus injects a sample through a fine nozzle to form an atomic beam. A DC discharge is used to elevate select atoms to a metastable energy level. These atoms are then acted on by a laser oriented orthogonally to the beam path to reduce the traverse velocity and to decrease the divergence angle of the beam. The beam then enters a Zeeman slower where a counter-propagating laser beam acts to slow the atoms down. Then select atoms are captured in a magneto-optical trap where they undergo fluorescence. A portion of the scattered photons are imaged onto a photo-detector, and the results analyzed to detect the presence of single atoms of the specific trace elements.

  4. Effects of Taiwan Roselle anthocyanin treatment and single-walled carbon nanotube addition on the performance of dye-sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Chou, C. S.; Tsai, P. J.; Wu, P.; Shu, G. G.; Huang, Y. H.; Chen, Y. S.

    2014-04-01

    This study investigates the relationship between the performance of a dye-sensitized solar cell (DSSC) sensitized by a natural sensitizer of Taiwan Roselle anthocyanin (TRA) and fabrication process conditions of the DSSC. A set of systematic experiments has been carried out at various soaking temperatures, soaking periods, sensitizer concentrations, pH values, and additions of single-walled carbon nanotube (SWCNT). An absorption peak (520 nm) is found for TRA, and it is close to that of the N719 dye (518 nm). At a fixed concentration of TRA and a fixed soaking period, a lower pH of the extract or a lower soaking temperature is found favorable to the formation of pigment cations, which leads to an enhanced power conversion efficiency (η) of DSSC. For instance, by applying 17.53 mg/100ml TRA at 30 for 10 h, as the pH of the extract decreases to 2.00 from 2.33 (the original pH of TRA), the η of DSSC with TiO2+SWCNT electrode increases to 0.67% from 0.11% of a traditional DSSC with TiO2 electrode. This performance improvement can be explained by the combined effect of the pH of sensitizer and the additions of SWCNT, a first investigation in DSSC using the natural sensitizer with SWCNT.

  5. Sensitivity analysis of ecosystem service valuation in a Mediterranean watershed.

    PubMed

    Sánchez-Canales, María; López Benito, Alfredo; Passuello, Ana; Terrado, Marta; Ziv, Guy; Acuña, Vicenç; Schuhmacher, Marta; Elorza, F Javier

    2012-12-01

    The services of natural ecosystems are clearly very important to our societies. In the last years, efforts to conserve and value ecosystem services have been fomented. By way of illustration, the Natural Capital Project integrates ecosystem services into everyday decision making around the world. This project has developed InVEST (a system for Integrated Valuation of Ecosystem Services and Tradeoffs). The InVEST model is a spatially integrated modelling tool that allows us to predict changes in ecosystem services, biodiversity conservation and commodity production levels. Here, InVEST model is applied to a stakeholder-defined scenario of land-use/land-cover change in a Mediterranean region basin (the Llobregat basin, Catalonia, Spain). Of all InVEST modules and sub-modules, only the behaviour of the water provisioning one is investigated in this article. The main novel aspect of this work is the sensitivity analysis (SA) carried out to the InVEST model in order to determine the variability of the model response when the values of three of its main coefficients: Z (seasonal precipitation distribution), prec (annual precipitation) and eto (annual evapotranspiration), change. The SA technique used here is a One-At-a-Time (OAT) screening method known as Morris method, applied over each one of the one hundred and fifty four sub-watersheds in which the Llobregat River basin is divided. As a result, this method provides three sensitivity indices for each one of the sub-watersheds under consideration, which are mapped to study how they are spatially distributed. From their analysis, the study shows that, in the case under consideration and between the limits considered for each factor, the effect of the Z coefficient on the model response is negligible, while the other two need to be accurately determined in order to obtain precise output variables. The results of this study will be applicable to the others watersheds assessed in the Consolider Scarce Project. PMID

  6. Uncertainty quantification and global sensitivity analysis of the Los Alamos sea ice model

    NASA Astrophysics Data System (ADS)

    Urrego-Blanco, Jorge R.; Urban, Nathan M.; Hunke, Elizabeth C.; Turner, Adrian K.; Jeffery, Nicole

    2016-04-01

    Changes in the high-latitude climate system have the potential to affect global climate through feedbacks with the atmosphere and connections with midlatitudes. Sea ice and climate models used to understand these changes have uncertainties that need to be characterized and quantified. We present a quantitative way to assess uncertainty in complex computer models, which is a new approach in the analysis of sea ice models. We characterize parametric uncertainty in the Los Alamos sea ice model (CICE) in a standalone configuration and quantify the sensitivity of sea ice area, extent, and volume with respect to uncertainty in 39 individual model parameters. Unlike common sensitivity analyses conducted in previous studies where parameters are varied one at a time, this study uses a global variance-based approach in which Sobol' sequences are used to efficiently sample the full 39-dimensional parameter space. We implement a fast emulator of the sea ice model whose predictions of sea ice extent, area, and volume are used to compute the Sobol' sensitivity indices of the 39 parameters. Main effects and interactions among the most influential parameters are also estimated by a nonparametric regression technique based on generalized additive models. A ranking based on the sensitivity indices indicates that model predictions are most sensitive to snow parameters such as snow conductivity and grain size, and the drainage of melt ponds. It is recommended that research be prioritized toward more accurately determining these most influential parameter values by observational studies or by improving parameterizations in the sea ice model.

  7. A Variance Decomposition Approach to Uncertainty Quantification and Sensitivity Analysis of the J&E Model

    PubMed Central

    Moradi, Ali; Tootkaboni, Mazdak; Pennell, Kelly G.

    2015-01-01

    The Johnson and Ettinger (J&E) model is the most widely used vapor intrusion model in the United States. It is routinely used as part of hazardous waste site assessments to evaluate the potential for vapor intrusion exposure risks. This study incorporates mathematical approaches that allow sensitivity and uncertainty of the J&E model to be evaluated. In addition to performing Monte Carlo simulations to examine the uncertainty in the J&E model output, a powerful global sensitivity analysis technique based on Sobol indices is used to evaluate J&E model sensitivity to variations in the input parameters. The results suggest that the J&E model is most sensitive to the building air exchange rate, regardless of soil type and source depth. Building air exchange rate is not routinely measured during vapor intrusion investigations, but clearly improved estimates and/or measurements of the air exchange rate would lead to improved model predictions. It is also found that the J&E model is more sensitive to effective diffusivity, than effective permeability. Field measurements of effective diffusivity are not commonly collected during vapor intrusion investigations; however, consideration of this parameter warrants additional attention. Finally, the effects of input uncertainties on model predictions for different scenarios (e.g. sandy soil as compared to clayey soil, and “shallow” sources as compared to “deep” sources) are evaluated. Our results, not only identify the range of variability to be expected depending on the scenario at hand, but also mark the important cases where special care is needed when estimating the input parameters to which the J&E model is most sensitive. PMID:25947051

  8. A variance decomposition approach to uncertainty quantification and sensitivity analysis of the Johnson and Ettinger model.

    PubMed

    Moradi, Ali; Tootkaboni, Mazdak; Pennell, Kelly G

    2015-02-01

    The Johnson and Ettinger (J&E) model is the most widely used vapor intrusion model in the United States. It is routinely used as part of hazardous waste site assessments to evaluate the potential for vapor intrusion exposure risks. This study incorporates mathematical approaches that allow sensitivity and uncertainty of the J&E model to be evaluated. In addition to performing Monte Carlo simulations to examine the uncertainty in the J&E model output, a powerful global sensitivity analysis technique based on Sobol indices is used to evaluate J&E model sensitivity to variations in the input parameters. The results suggest that the J&E model is most sensitive to the building air exchange rate, regardless of soil type and source depth. Building air exchange rate is not routinely measured during vapor intrusion investigations, but clearly improved estimates and/or measurements of the air exchange rate would lead to improved model predictions. It is also found that the J&E model is more sensitive to effective diffusivity than to effective permeability. Field measurements of effective diffusivity are not commonly collected during vapor intrusion investigations; however, consideration of this parameter warrants additional attention. Finally, the effects of input uncertainties on model predictions for different scenarios (e.g., sandy soil as compared to clayey soil, and "shallow" sources as compared to "deep" sources) are evaluated. Our results not only identify the range of variability to be expected depending on the scenario at hand, but also mark the important cases where special care is needed when estimating the input parameters to which the J&E model is most sensitive. PMID:25947051

  9. SAMURAI: Sensitivity analysis of a meta-analysis with unpublished but registered analytical investigations (software)

    PubMed Central

    2014-01-01

    Background The non-availability of clinical trial results contributes to publication bias, diminishing the validity of systematic reviews and meta-analyses. Although clinical trial registries have been established to reduce non-publication, the results from over half of all trials registered in ClinicalTrials.gov remain unpublished even 30 months after completion. Our goals were i) to utilize information available in registries (specifically, the number and sample sizes of registered unpublished studies) to gauge the sensitivity of a meta-analysis estimate of the effect size and its confidence interval to the non-publication of studies and ii) to develop user-friendly open-source software to perform this quantitative sensitivity analysis. Methods The open-source software, the R package SAMURAI, was developed using R functions available in the R package metafor. The utility of SAMURAI is illustrated with two worked examples. Results Our open-source software SAMURAI, can handle meta-analytic datasets of clinical trials with two independent treatment arms. Both binary and continuous outcomes are supported. For each unpublished study, the dataset requires only the sample sizes of each treatment arm and the user predicted ‘outlook’ for the studies. The user can specify five outlooks ranging from ‘very positive’ (i.e., very favorable towards intervention) to ‘very negative’ (i.e., very favorable towards control). SAMURAI assumes that control arms of unpublished studies have effects similar to the effect across control arms of published studies. For each experimental arm of an unpublished study, utilizing the user-provided outlook, SAMURAI randomly generates an effect estimate using a probability distribution, which may be based on a summary effect across published trials. SAMURAI then calculates the estimated summary treatment effect with a random effects model (DerSimonian & Laird method), and outputs the result as a forest plot. Conclusions To our

  10. Sensitivity analysis for Probabilistic Tsunami Hazard Assessment (PTHA)

    NASA Astrophysics Data System (ADS)

    Spada, M.; Basili, R.; Selva, J.; Lorito, S.; Sorensen, M. B.; Zonker, J.; Babeyko, A. Y.; Romano, F.; Piatanesi, A.; Tiberti, M.

    2012-12-01

    In modern societies, probabilistic hazard assessment of natural disasters is commonly used by decision makers for designing regulatory standards and, more generally, for prioritizing risk mitigation efforts. Systematic formalization of Probabilistic Tsunami Hazard Assessment (PTHA) has started only in recent years, mainly following the giant tsunami disaster of Sumatra in 2004. Typically, PTHA for earthquake sources exploits the long-standing practices developed in probabilistic seismic hazard assessment (PSHA), even though important differences are evident. In PTHA, for example, it is known that far-field sources are more important and that physical models for tsunami propagation are needed for the highly non-isotropic propagation of tsunami waves. However, considering the high impact that PTHA may have on societies, an important effort to quantify the effect of specific assumptions should be performed. Indeed, specific standard hypotheses made in PSHA may prove inappropriate for PTHA, since tsunami waves are sensitive to different aspects of sources (e.g. fault geometry, scaling laws, slip distribution) and propagate differently. In addition, the necessity of running an explicit calculation of wave propagation for every possible event (tsunami scenario) forces analysts to finding strategies for diminishing the computational burden. In this work, we test the sensitivity of hazard results with respect to several assumptions that are peculiar of PTHA and others that are commonly accepted in PSHA. Our case study is located in the central Mediterranean Sea and considers the Western Hellenic Arc as the earthquake source with Crete and Eastern Sicily as near-field and far-field target coasts, respectively. Our suite of sensitivity tests includes: a) comparison of random seismicity distribution within area sources as opposed to systematically distributed ruptures on fault sources; b) effects of statistical and physical parameters (a- and b-value, Mc, Mmax, scaling laws

  11. Breathing dynamics based parameter sensitivity analysis of hetero-polymeric DNA

    SciTech Connect

    Talukder, Srijeeta; Sen, Shrabani; Chaudhury, Pinaki; Chakraborti, Prantik; Banik, Suman K.

    2014-03-28

    We study the parameter sensitivity of hetero-polymeric DNA within the purview of DNA breathing dynamics. The degree of correlation between the mean bubble size and the model parameters is estimated for this purpose for three different DNA sequences. The analysis leads us to a better understanding of the sequence dependent nature of the breathing dynamics of hetero-polymeric DNA. Out of the 14 model parameters for DNA stability in the statistical Poland-Scheraga approach, the hydrogen bond interaction ε{sub hb}(AT) for an AT base pair and the ring factor ξ turn out to be the most sensitive parameters. In addition, the stacking interaction ε{sub st}(TA-TA) for an TA-TA nearest neighbor pair of base-pairs is found to be the most sensitive one among all stacking interactions. Moreover, we also establish that the nature of stacking interaction has a deciding effect on the DNA breathing dynamics, not the number of times a particular stacking interaction appears in a sequence. We show that the sensitivity analysis can be used as an effective measure to guide a stochastic optimization technique to find the kinetic rate constants related to the dynamics as opposed to the case where the rate constants are measured using the conventional unbiased way of optimization.

  12. Breathing dynamics based parameter sensitivity analysis of hetero-polymeric DNA

    NASA Astrophysics Data System (ADS)

    Talukder, Srijeeta; Sen, Shrabani; Chakraborti, Prantik; Metzler, Ralf; Banik, Suman K.; Chaudhury, Pinaki

    2014-03-01

    We study the parameter sensitivity of hetero-polymeric DNA within the purview of DNA breathing dynamics. The degree of correlation between the mean bubble size and the model parameters is estimated for this purpose for three different DNA sequences. The analysis leads us to a better understanding of the sequence dependent nature of the breathing dynamics of hetero-polymeric DNA. Out of the 14 model parameters for DNA stability in the statistical Poland-Scheraga approach, the hydrogen bond interaction ɛ _{hb}({AT}) for an {AT} base pair and the ring factor ξ turn out to be the most sensitive parameters. In addition, the stacking interaction ɛ _{st}({TA}-{TA}) for an {TA}-{TA} nearest neighbor pair of base-pairs is found to be the most sensitive one among all stacking interactions. Moreover, we also establish that the nature of stacking interaction has a deciding effect on the DNA breathing dynamics, not the number of times a particular stacking interaction appears in a sequence. We show that the sensitivity analysis can be used as an effective measure to guide a stochastic optimization technique to find the kinetic rate constants related to the dynamics as opposed to the case where the rate constants are measured using the conventional unbiased way of optimization.

  13. General methods for sensitivity analysis of equilibrium dynamics in patch occupancy models

    USGS Publications Warehouse

    Miller, David A.W.

    2012-01-01

    Sensitivity analysis is a useful tool for the study of ecological models that has many potential applications for patch occupancy modeling. Drawing from the rich foundation of existing methods for Markov chain models, I demonstrate new methods for sensitivity analysis of the equilibrium state dynamics of occupancy models. Estimates from three previous studies are used to illustrate the utility of the sensitivity calculations: a joint occupancy model for a prey species, its predators, and habitat used by both; occurrence dynamics from a well-known metapopulation study of three butterfly species; and Golden Eagle occupancy and reproductive dynamics. I show how to deal efficiently with multistate models and how to calculate sensitivities involving derived state variables and lower-level parameters. In addition, I extend methods to incorporate environmental variation by allowing for spatial and temporal variability in transition probabilities. The approach used here is concise and general and can fully account for environmental variability in transition parameters. The methods can be used to improve inferences in occupancy studies by quantifying the effects of underlying parameters, aiding prediction of future system states, and identifying priorities for sampling effort.

  14. Design Parameters Influencing Reliability of CCGA Assembly: A Sensitivity Analysis

    NASA Technical Reports Server (NTRS)

    Tasooji, Amaneh; Ghaffarian, Reza; Rinaldi, Antonio

    2006-01-01

    Area Array microelectronic packages with small pitch and large I/O counts are now widely used in microelectronics packaging. The impact of various package design and materials/process parameters on reliability has been studied through extensive literature review. Reliability of Ceramic Column Grid Array (CCGA) package assemblies has been evaluated using JPL thermal cycle test results (-50(deg)/75(deg)C, -55(deg)/100(deg)C, and -55(deg)/125(deg)C), as well as those reported by other investigators. A sensitivity analysis has been performed using the literature da to study the impact of design parameters and global/local stress conditions on assembly reliability. The applicability of various life-prediction models for CCGA design has been investigated by comparing model's predictions with the experimental thermal cycling data. Finite Element Method (FEM) analysis has been conducted to assess the state of the stress/strain in CCGA assembly under different thermal cycling, and to explain the different failure modes and locations observed in JPL test assemblies.

  15. SENSITIVITY ANALYSIS FOR I-129 WASTES: EFFECT OF HYDRAULIC CONDUCTIVITY

    SciTech Connect

    Ades, M; Leonard Collard, L

    2007-01-12

    Solid low-level radioactive wastes at the Savannah River Site (SRS) are disposed in trenches. In order to determine the permissible radioactive inventory limits for such disposal facilities, it is required to assess the behavior of radioactive waste material over long periods of time. The sensitivity of flow and I-129 (and similar radionuclides) transport in groundwater in the vadose zone to the hydraulic conductivities of the vadose zone subregions and the low-level waste is identified and quantified. A trench configuration and simulation model have been developed to analyze the flow and transport of the radionuclide in the vadose zone as it migrates to the groundwater table. The analysis identifies and quantifies the major dependencies of the flow and radionuclide fractional flux on the subregion hydraulic conductivities. Analysis results indicate the importance of the hydraulic conductivity assigned to the materials modeled, thereby providing the modeler and decision makers with valuable insights on the potential impact of the hydraulic conductivity on flow and radionuclide transport.

  16. Global sensitivity analysis of analytical vibroacoustic transmission models

    NASA Astrophysics Data System (ADS)

    Christen, Jean-Loup; Ichchou, Mohamed; Troclet, Bernard; Bareille, Olivier; Ouisse, Morvan

    2016-04-01

    Noise reduction issues arise in many engineering problems. One typical vibroacoustic problem is the transmission loss (TL) optimisation and control. The TL depends mainly on the mechanical parameters of the considered media. At early stages of the design, such parameters are not well known. Decision making tools are therefore needed to tackle this issue. In this paper, we consider the use of the Fourier Amplitude Sensitivity Test (FAST) for the analysis of the impact of mechanical parameters on features of interest. FAST is implemented with several structural configurations. FAST method is used to estimate the relative influence of the model parameters while assuming some uncertainty or variability on their values. The method offers a way to synthesize the results of a multiparametric analysis with large variability. Results are presented for transmission loss of isotropic, orthotropic and sandwich plates excited by a diffuse field on one side. Qualitative trends found to agree with the physical expectation. Design rules can then be set up for vibroacoustic indicators. The case of a sandwich plate is taken as an example of the use of this method inside an optimisation process and for uncertainty quantification.

  17. Fault sensitivity and wear-out analysis of VLSI systems

    NASA Astrophysics Data System (ADS)

    Choi, Gwan Seung

    1994-07-01

    This thesis describes simulation approaches to conduct fault sensitivity and wear-out failure analysis of VLSI systems. A fault-injection approach to study transient impact in VLSI systems is developed. Through simulated fault injection at the device level and, subsequent fault propagation at the gate functional and software levels, it is possible to identify critical bottlenecks in dependability. Techniques to speed up the fault simulation and to perform statistical analysis of fault-impact are developed. A wear-out simulation environment is also developed to closely mimic dynamic sequences of wear-out events in a device through time, to localize weak location/aspect of target chip and to allow generation of TTF (Time-to-failure) distribution of VLSI chip as a whole. First, an accurate simulation of a target chip and its application code is performed to acquire trace data (real workload) on switch activity. Then, using this switch activity information, wear-out of the each component in the entire chip is simulated using Monte Carlo techniques.

  18. Parametric sensitivity analysis for biochemical reaction networks based on pathwise information theory

    PubMed Central

    2013-01-01

    Background Stochastic modeling and simulation provide powerful predictive methods for the intrinsic understanding of fundamental mechanisms in complex biochemical networks. Typically, such mathematical models involve networks of coupled jump stochastic processes with a large number of parameters that need to be suitably calibrated against experimental data. In this direction, the parameter sensitivity analysis of reaction networks is an essential mathematical and computational tool, yielding information regarding the robustness and the identifiability of model parameters. However, existing sensitivity analysis approaches such as variants of the finite difference method can have an overwhelming computational cost in models with a high-dimensional parameter space. Results We develop a sensitivity analysis methodology suitable for complex stochastic reaction networks with a large number of parameters. The proposed approach is based on Information Theory methods and relies on the quantification of information loss due to parameter perturbations between time-series distributions. For this reason, we need to work on path-space, i.e., the set consisting of all stochastic trajectories, hence the proposed approach is referred to as “pathwise”. The pathwise sensitivity analysis method is realized by employing the rigorously-derived Relative Entropy Rate, which is directly computable from the propensity functions. A key aspect of the method is that an associated pathwise Fisher Information Matrix (FIM) is defined, which in turn constitutes a gradient-free approach to quantifying parameter sensitivities. The structure of the FIM turns out to be block-diagonal, revealing hidden parameter dependencies and sensitivities in reaction networks. Conclusions As a gradient-free method, the proposed sensitivity analysis provides a significant advantage when dealing with complex stochastic systems with a large number of parameters. In addition, the knowledge of the structure of the

  19. Lock Acquisition and Sensitivity Analysis of Advanced LIGO Interferometers

    NASA Astrophysics Data System (ADS)

    Martynov, Denis

    Laser interferometer gravitational wave observatory (LIGO) consists of two complex large-scale laser interferometers designed for direct detection of gravitational waves from distant astrophysical sources in the frequency range 10Hz - 5kHz. Direct detection of space-time ripples will support Einstein's general theory of relativity and provide invaluable information and new insight into physics of the Universe. The initial phase of LIGO started in 2002, and since then data was collected during the six science runs. Instrument sensitivity improved from run to run due to the effort of commissioning team. Initial LIGO has reached designed sensitivity during the last science run, which ended in October 2010. In parallel with commissioning and data analysis with the initial detector, LIGO group worked on research and development of the next generation of detectors. Major instrument upgrade from initial to advanced LIGO started in 2010 and lasted until 2014. This thesis describes results of commissioning work done at the LIGO Livingston site from 2013 until 2015 in parallel with and after the installation of the instrument. This thesis also discusses new techniques and tools developed at the 40m prototype including adaptive filtering, estimation of quantization noise in digital filters and design of isolation kits for ground seismometers. The first part of this thesis is devoted to the description of methods for bringing the interferometer into linear regime when collection of data becomes possible. States of longitudinal and angular controls of interferometer degrees of freedom during lock acquisition process and in low noise configuration are discussed in details. Once interferometer is locked and transitioned to low noise regime, instrument produces astrophysics data that should be calibrated to units of meters or strain. The second part of this thesis describes online calibration technique set up in both observatories to monitor the quality of the collected data in

  20. On the sensitivity analysis of separated-loop MRS data

    NASA Astrophysics Data System (ADS)

    Behroozmand, A.; Auken, E.; Fiandaca, G.

    2013-12-01

    In this study we investigate the sensitivity analysis of separated-loop magnetic resonance sounding (MRS) data and, in light of deploying a separate MRS receiver system from the transmitter system, compare the parameter determination of the separated-loop with the conventional coincident-loop MRS data. MRS has emerged as a promising surface-based geophysical technique for groundwater investigations, as it provides a direct estimate of the water content. The method works based on the physical principle of NMR during which a large volume of protons of the water molecules in the subsurface is excited at the specific Larmor frequency. The measurement consists of a large wire loop (typically 25 - 100 m in side length/diameter) deployed on the surface which typically acts as both a transmitter and a receiver, the so-called coincident-loop configuration. An alternating current is passed through the loop deployed and the superposition of signals from all precessing protons within the investigated volume is measured in a receiver loop; a decaying NMR signal called Free Induction Decay (FID). To provide depth information, the FID signal is measured for a series of pulse moments (Q; product of current amplitude and transmitting pulse length) during which different earth volumes are excited. One of the main and inevitable limitations of MRS measurements is a relatively long measurement dead time, i.e. a non-zero time between the end of the energizing pulse and the beginning of the measurement, which makes it difficult, and in some places impossible, to record SNMR signal from fine-grained geologic units and limits the application of advanced pulse sequences. Therefore, one of the current research activities is the idea of building separate receiver units, which will diminish the dead time. In light of that, the aims of this study are twofold: 1) Using a forward modeling approach, the sensitivity kernels of different separated-loop MRS soundings are studied and compared with

  1. Sensitivity to Excluding Treatments in Network Meta-analysis.

    PubMed

    Lin, Lifeng; Chu, Haitao; Hodges, James S

    2016-07-01

    Network meta-analysis of randomized controlled trials is increasingly used to combine both direct evidence comparing treatments within trials and indirect evidence comparing treatments across different trials. When the outcome is binary, the commonly used contrast-based network meta-analysis methods focus on relative treatment effects such as odds ratios comparing two treatments. As shown in a recent report, when using contrast-based network meta-analysis, the impact of excluding a treatment in the network can be substantial, suggesting a methodological limitation. In addition, relative treatment effects are sometimes not sufficient for patients to make decisions. For example, it can be challenging for patients to trade off efficacy and safety for two drugs if they only know the relative effects, not the absolute effects. A recently proposed arm-based network meta-analysis, based on a missing-data framework, provides an alternative approach. It focuses on estimating population-averaged treatment-specific absolute effects. This article examines the influence of treatment exclusion empirically using 14 published network meta-analyses, for both arm- and contrast-based approaches. The difference between these two approaches is substantial, and it is almost entirely due to single-arm trials. When a treatment is removed from a contrast-based network meta-analysis, it is necessary to exclude other treatments in two-arm studies that investigated the excluded treatment; such exclusions are not necessary in arm-based network meta-analysis, leading to substantial gain in performance. PMID:27007642

  2. A new variance-based global sensitivity analysis technique

    NASA Astrophysics Data System (ADS)

    Wei, Pengfei; Lu, Zhenzhou; Song, Jingwen

    2013-11-01

    A new set of variance-based sensitivity indices, called W-indices, is proposed. Similar to the Sobol's indices, both main and total effect indices are defined. The W-main effect indices measure the average reduction of model output variance when the ranges of a set of inputs are reduced, and the total effect indices quantify the average residual variance when the ranges of the remaining inputs are reduced. Geometrical interpretations show that the W-indices gather the full information of the variance ratio function, whereas, Sobol's indices only reflect the marginal information. Then the double-loop-repeated-set Monte Carlo (MC) (denoted as DLRS MC) procedure, the double-loop-single-set MC (denoted as DLSS MC) procedure and the model emulation procedure are introduced for estimating the W-indices. It is shown that the DLRS MC procedure is suitable for computing all the W-indices despite its highly computational cost. The DLSS MC procedure is computationally efficient, however, it is only applicable for computing low order indices. The model emulation is able to estimate all the W-indices with low computational cost as long as the model behavior is correctly captured by the emulator. The Ishigami function, a modified Sobol's function and two engineering models are utilized for comparing the W- and Sobol's indices and verifying the efficiency and convergence of the three numerical methods. Results show that, for even an additive model, the W-total effect index of one input may be significantly larger than its W-main effect index. This indicates that there may exist interaction effects among the inputs of an additive model when their distribution ranges are reduced.

  3. Analysis methods for the determination of anthropogenic additions of P to agricultural soils

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Phosphorus additions and measurement in soil is of concern on lands where biosolids have been applied. Colorimetric analysis for plant-available P may be inadequate for the accurate assessment of soil P. Phosphate additions in a regulatory environment need to be accurately assessed as the reported...

  4. The quantitative surface analysis of an antioxidant additive in a lubricant oil matrix by desorption electrospray ionization mass spectrometry

    PubMed Central

    Da Costa, Caitlyn; Reynolds, James C; Whitmarsh, Samuel; Lynch, Tom; Creaser, Colin S

    2013-01-01

    RATIONALE Chemical additives are incorporated into commercial lubricant oils to modify the physical and chemical properties of the lubricant. The quantitative analysis of additives in oil-based lubricants deposited on a surface without extraction of the sample from the surface presents a challenge. The potential of desorption electrospray ionization mass spectrometry (DESI-MS) for the quantitative surface analysis of an oil additive in a complex oil lubricant matrix without sample extraction has been evaluated. METHODS The quantitative surface analysis of the antioxidant additive octyl (4-hydroxy-3,5-di-tert-butylphenyl)propionate in an oil lubricant matrix was carried out by DESI-MS in the presence of 2-(pentyloxy)ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate as an internal standard. A quadrupole/time-of-flight mass spectrometer fitted with an in-house modified ion source enabling non-proximal DESI-MS was used for the analyses. RESULTS An eight-point calibration curve ranging from 1 to 80 µg/spot of octyl (4-hydroxy-3,5-di-tert-butylphenyl)propionate in an oil lubricant matrix and in the presence of the internal standard was used to determine the quantitative response of the DESI-MS method. The sensitivity and repeatability of the technique were assessed by conducting replicate analyses at each concentration. The limit of detection was determined to be 11 ng/mm2 additive on spot with relative standard deviations in the range 3–14%. CONCLUSIONS The application of DESI-MS to the direct, quantitative surface analysis of a commercial lubricant additive in a native oil lubricant matrix is demonstrated. © 2013 The Authors. Rapid Communications in Mass Spectrometry published by John Wiley & Sons, Ltd. PMID:24097398

  5. Enhanced photovoltaic performance of Cu-based metal-organic frameworks sensitized solar cell by addition of carbon nanotubes

    PubMed Central

    Lee, Deok Yeon; Shin, Chan Yong; Yoon, Seog Joon; Lee, Haw Young; Lee, Wonjoo; Shrestha, Nabeen K.; Lee, Joong Kee; Han, Sung-Hwan

    2014-01-01

    In the present work, TiO2 nanoparticle and multi-walled carbon nanotubes composite powder is prepared hydrothermally. After doctor blading the paste from composite powder, the resulted composite film is sensitized with Cu-based metal-organic frameworks using a layer-by-layer deposition technique and the film is characterized using FE-SEM, EDX, XRD, UV/Visible spectrophotometry and photoluminescence spectroscopy. The influence of the carbon nanotubes in photovoltaic performance is studied by constructing a Grätzel cell with I3−/I− redox couple containing electrolyte. The results demonstrate that the introduction of carbon nanotubes accelerates the electron transfer, and thereby enhances the photovoltaic performance of the cell with a nearly 60% increment in power conversion efficiency. PMID:24488110

  6. Enhanced photovoltaic performance of Cu-based metal-organic frameworks sensitized solar cell by addition of carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Lee, Deok Yeon; Shin, Chan Yong; Yoon, Seog Joon; Lee, Haw Young; Lee, Wonjoo; Shrestha, Nabeen K.; Lee, Joong Kee; Han, Sung-Hwan

    2014-02-01

    In the present work, TiO2 nanoparticle and multi-walled carbon nanotubes composite powder is prepared hydrothermally. After doctor blading the paste from composite powder, the resulted composite film is sensitized with Cu-based metal-organic frameworks using a layer-by-layer deposition technique and the film is characterized using FE-SEM, EDX, XRD, UV/Visible spectrophotometry and photoluminescence spectroscopy. The influence of the carbon nanotubes in photovoltaic performance is studied by constructing a Grätzel cell with I3-/I- redox couple containing electrolyte. The results demonstrate that the introduction of carbon nanotubes accelerates the electron transfer, and thereby enhances the photovoltaic performance of the cell with a nearly 60% increment in power conversion efficiency.

  7. Exploring the impact of forcing error characteristics on physically based snow simulations within a global sensitivity analysis framework

    NASA Astrophysics Data System (ADS)

    Raleigh, M. S.; Lundquist, J. D.; Clark, M. P.

    2014-12-01

    Physically based models provide insights into key hydrologic processes, but are associated with uncertainties due to deficiencies in forcing data, model parameters, and model structure. Forcing uncertainty is enhanced in snow-affected catchments, where weather stations are scarce and prone to measurement errors, and meteorological variables exhibit high variability. Hence, there is limited understanding of how forcing error characteristics affect simulations of cold region hydrology. Here we employ global sensitivity analysis to explore how different error types (i.e., bias, random errors), different error distributions, and different error magnitudes influence physically based simulations of four snow variables (snow water equivalent, ablation rates, snow disappearance, and sublimation). We use Sobol' global sensitivity analysis, which is typically used for model parameters, but adapted here for testing model sensitivity to co-existing errors in all forcings. We quantify the Utah Energy Balance model's sensitivity to forcing errors with 1 520 000 Monte Carlo simulations across four sites and four different scenarios. Model outputs were generally (1) more sensitive to forcing biases than random errors, (2) less sensitive to forcing error distributions, and (3) sensitive to different forcings depending on the relative magnitude of errors. For typical error magnitudes, precipitation bias was the most important factor for snow water equivalent, ablation rates, and snow disappearance timing, but other forcings had a significant impact depending on forcing error magnitudes. Additionally, the relative importance of forcing errors depended on the model output of interest. Sensitivity analysis can reveal which forcing error characteristics matter most for hydrologic modeling.

  8. Thick activation detectors for neutron spectrometry using different unfolding methods: sensitivity analysis and dose calculation.

    PubMed

    Medkour Ishak-Boushaki, Ghania; Boukeffoussa, Khelifa; Idiri, Zahir; Allab, Malika

    2012-03-01

    This paper discusses the use of threshold detectors of extended sizes for low intensity neutron fields' characterization. The detectors were tested by the measurement of the neutron spectrum of an (241)Am-Be source. Integral quantities characterizing the neutron field, required for radiological protection, have been derived by unfolding the measured data. A good agreement is achieved between the obtained results and those deduced using Bonner spheres. In addition, a sensitivity analysis of the results to the deconvolution procedure is given. PMID:22119561

  9. Thermal sensitivity analysis data utilizing Q10 scanning, Boltzmann slope factor and the change of molar heat capacity

    PubMed Central

    Kang, KyeongJin

    2016-01-01

    As a further elaboration of the recently devised Q10 scanning analysis (“Exceptionally high thermal sensitivity of rattlesnake TRPA1 correlates with peak current amplitude” [1]), the interval between current data points at two temperatures was shortened and the resulting parameters representing thermal sensitivities such as peak Q10s and temperature points of major thermosensitivity events are presented for two TRPA1 orthologues from rattlesnakes and boas. In addition, the slope factors from Boltzmann fitting and the change of molar heat capacity of temperature-evoked currents were evaluated and compared as alternative ways of thermal sensitivity appraisal of TRPA1 orthologues. PMID:26870758

  10. Thermal sensitivity analysis data utilizing Q10 scanning, Boltzmann slope factor and the change of molar heat capacity.

    PubMed

    Kang, KyeongJin

    2016-03-01

    As a further elaboration of the recently devised Q10 scanning analysis ("Exceptionally high thermal sensitivity of rattlesnake TRPA1 correlates with peak current amplitude" [1]), the interval between current data points at two temperatures was shortened and the resulting parameters representing thermal sensitivities such as peak Q10s and temperature points of major thermosensitivity events are presented for two TRPA1 orthologues from rattlesnakes and boas. In addition, the slope factors from Boltzmann fitting and the change of molar heat capacity of temperature-evoked currents were evaluated and compared as alternative ways of thermal sensitivity appraisal of TRPA1 orthologues. PMID:26870758

  11. What Do We Mean By Sensitivity Analysis? The Need For A Comprehensive Characterization Of Sensitivity In Earth System Models

    NASA Astrophysics Data System (ADS)

    Razavi, S.; Gupta, H. V.

    2014-12-01

    Sensitivity analysis (SA) is an important paradigm in the context of Earth System model development and application, and provides a powerful tool that serves several essential functions in modelling practice, including 1) Uncertainty Apportionment - attribution of total uncertainty to different uncertainty sources, 2) Assessment of Similarity - diagnostic testing and evaluation of similarities between the functioning of the model and the real system, 3) Factor and Model Reduction - identification of non-influential factors and/or insensitive components of model structure, and 4) Factor Interdependence - investigation of the nature and strength of interactions between the factors, and the degree to which factors intensify, cancel, or compensate for the effects of each other. A variety of sensitivity analysis approaches have been proposed, each of which formally characterizes a different "intuitive" understanding of what is meant by the "sensitivity" of one or more model responses to its dependent factors (such as model parameters or forcings). These approaches are based on different philosophies and theoretical definitions of sensitivity, and range from simple local derivatives and one-factor-at-a-time procedures to rigorous variance-based (Sobol-type) approaches. In general, each approach focuses on, and identifies, different features and properties of the model response and may therefore lead to different (even conflicting) conclusions about the underlying sensitivity. This presentation revisits the theoretical basis for sensitivity analysis, and critically evaluates existing approaches so as to demonstrate their flaws and shortcomings. With this background, we discuss several important properties of response surfaces that are associated with the understanding and interpretation of sensitivity. Finally, a new approach towards global sensitivity assessment is developed that is consistent with important properties of Earth System model response surfaces.

  12. LSENS, a general chemical kinetics and sensitivity analysis code for gas-phase reactions: User's guide

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, Krishnan; Bittker, David A.

    1993-01-01

    A general chemical kinetics and sensitivity analysis code for complex, homogeneous, gas-phase reactions is described. The main features of the code, LSENS, are its flexibility, efficiency and convenience in treating many different chemical reaction models. The models include static system, steady, one-dimensional, inviscid flow, shock initiated reaction, and a perfectly stirred reactor. In addition, equilibrium computations can be performed for several assigned states. An implicit numerical integration method, which works efficiently for the extremes of very fast and very slow reaction, is used for solving the 'stiff' differential equation systems that arise in chemical kinetics. For static reactions, sensitivity coefficients of all dependent variables and their temporal derivatives with respect to the initial values of dependent variables and/or the rate coefficient parameters can be computed. This paper presents descriptions of the code and its usage, and includes several illustrative example problems.

  13. A comprehensive sensitivity analysis of central-loop MRS data

    NASA Astrophysics Data System (ADS)

    Behroozmand, Ahmad; Auken, Esben; Dalgaard, Esben; Rejkjaer, Simon

    2014-05-01

    In this study we investigate the sensitivity analysis of separated-loop magnetic resonance sounding (MRS) data and, in light of deploying a separate MRS receiver system from the transmitter system, compare the parameter determination of the central-loop with the conventional coincident-loop MRS data. MRS, also called surface NMR, has emerged as a promising surface-based geophysical technique for groundwater investigations, as it provides a direct estimate of the water content and, through empirical relations, is linked to hydraulic properties of the subsurface such as hydraulic conductivity. The method works based on the physical principle of NMR during which a large volume of protons of the water molecules in the subsurface is excited at the specific Larmor frequency. The measurement consists of a large wire loop deployed on the surface which typically acts as both a transmitter and a receiver, the so-called coincident-loop configuration. An alternating current is passed through the loop deployed and the superposition of signals from all precessing protons within the investigated volume is measured in a receiver loop; a decaying NMR signal called Free Induction Decay (FID). To provide depth information, the FID signal is measured for a series of pulse moments (Q; product of current amplitude and transmitting pulse length) during which different earth volumes are excited. One of the main and inevitable limitations of MRS measurements is a relatively long measurement dead time, i.e. a non-zero time between the end of the energizing pulse and the beginning of the measurement, which makes it difficult, and in some places impossible, to record MRS signal from fine-grained geologic units and limits the application of advanced pulse sequences. Therefore, one of the current research activities is the idea of building separate receiver units, which will diminish the dead time. In light of that, the aims of this study are twofold: 1) Using a forward modeling approach, the

  14. Analysis of CNT additives in porous layered thin film lubrication with electric double layer

    NASA Astrophysics Data System (ADS)

    Rao, T. V. V. L. N.; Rani, A. M. A.; Sufian, S.; Mohamed, N. M.

    2015-07-01

    This paper presents an analysis of thin film lubrication of porous layered carbon nanotubes (CNTs) additive slider bearing with electric double layer. The CNTs additive lubricant flow in the thin fluid film and porous layers are governed by Stokes and Brinkman equations respectively, including electro-kinetic force. The apparent viscosity and nondimensional pressure expression are derived. The nondimensional load capacity increases under the influence of electro-viscosity, CNT additives volume fraction, permeability and thickness of porous layer. A CNTs additive lubricated porous thin film slider bearing with electric double layer provides higher load capacity.

  15. Advances in Sensitivity Analysis Capabilities with SCALE 6.0 and 6.1

    SciTech Connect

    Rearden, Bradley T; Petrie Jr, Lester M; Williams, Mark L

    2010-01-01

    The sensitivity and uncertainty analysis sequences of SCALE compute the sensitivity of k{sub eff} to each constituent multigroup cross section using perturbation theory based on forward and adjoint transport computations with several available codes. Versions 6.0 and 6.1 of SCALE, released in 2009 and 2010, respectively, include important additions to the TSUNAMI-3D sequence, which computes forward and adjoint solutions in multigroup with the KENO Monte Carlo codes. Previously, sensitivity calculations were performed with the simple and efficient geometry capabilities of KENO V.a, but now calculations can also be performed with the generalized geometry code KENO-VI. TSUNAMI-3D requires spatial refinement of the angular flux moment solutions for the forward and adjoint calculations. These refinements are most efficiently achieved with the use of a mesh accumulator. For SCALE 6.0, a more flexible mesh accumulator capability has been added to the KENO codes, enabling varying granularity of the spatial refinement to optimize the calculation for different regions of the system model. The new mesh capabilities allow the efficient calculation of larger models than were previously possible. Additional improvements in the TSUNAMI calculations were realized in the computation of implicit effects of resonance self-shielding on the final sensitivity coefficients. Multigroup resonance self-shielded cross sections are accurately computed with SCALE's robust deterministic continuous-energy treatment for the resolved and thermal energy range and with Bondarenko shielding factors elsewhere, including the unresolved resonance range. However, the sensitivities of the self-shielded cross sections to the parameters input to the calculation are quantified using only full-range Bondarenko factors.

  16. Sensitivity analysis of surface runoff generation in urban flood forecasting.

    PubMed

    Simões, N E; Leitão, J P; Maksimović, C; Sá Marques, A; Pina, R

    2010-01-01

    Reliable flood forecasting requires hydraulic models capable to estimate pluvial flooding fast enough in order to enable successful operational responses. Increased computational speed can be achieved by using a 1D/1D model, since 2D models are too computationally demanding. Further changes can be made by simplifying 1D network models, removing and by changing some secondary elements. The Urban Water Research Group (UWRG) of Imperial College London developed a tool that automatically analyses, quantifies and generates 1D overland flow network. The overland flow network features (ponds and flow pathways) generated by this methodology are dependent on the number of sewer network manholes and sewer inlets, as some of the overland flow pathways start at manholes (or sewer inlets) locations. Thus, if a simplified version of the sewer network has less manholes (or sewer inlets) than the original one, the overland flow network will be consequently different. This paper compares different overland flow networks generated with different levels of sewer network skeletonisation. Sensitivity analysis is carried out in one catchment area in Coimbra, Portugal, in order to evaluate overland flow network characteristics. PMID:20453333

  17. Potassium Buffering in the Neurovascular Unit: Models and Sensitivity Analysis

    PubMed Central

    Witthoft, Alexandra; Filosa, Jessica A.; Karniadakis, George Em

    2013-01-01

    Astrocytes are critical regulators of neural and neurovascular network communication. Potassium transport is a central mechanism behind their many functions. Astrocytes encircle synapses with their distal processes, which express two potassium pumps (Na-K and NKCC) and an inward rectifying potassium channel (Kir), whereas the vessel-adjacent endfeet express Kir and BK potassium channels. We provide a detailed model of potassium flow throughout the neurovascular unit (synaptic region, astrocytes, and arteriole) for the cortex of the young brain. Our model reproduces several phenomena observed experimentally: functional hyperemia, in which neural activity triggers astrocytic potassium release at the perivascular endfoot, inducing arteriole dilation; K+ undershoot in the synaptic space after periods of neural activity; neurally induced astrocyte hyperpolarization during Kir blockade. Our results suggest that the dynamics of the vascular response during functional hyperemia are governed by astrocytic Kir for the fast onset and astrocytic BK for maintaining dilation. The model supports the hypothesis that K+ undershoot is caused by excessive astrocytic uptake through Na-K and NKCC pumps, whereas the effect is balanced by Kir. We address parametric uncertainty using high-dimensional stochastic sensitivity analysis and identify possible model limitations. PMID:24209849

  18. Sensitivity analysis and optimization of the nuclear fuel cycle

    SciTech Connect

    Passerini, S.; Kazimi, M. S.; Shwageraus, E.

    2012-07-01

    A sensitivity study has been conducted to assess the robustness of the conclusions presented in the MIT Fuel Cycle Study. The Once Through Cycle (OTC) is considered as the base-line case, while advanced technologies with fuel recycling characterize the alternative fuel cycles. The options include limited recycling in LWRs and full recycling in fast reactors and in high conversion LWRs. Fast reactor technologies studied include both oxide and metal fueled reactors. The analysis allowed optimization of the fast reactor conversion ratio with respect to desired fuel cycle performance characteristics. The following parameters were found to significantly affect the performance of recycling technologies and their penetration over time: Capacity Factors of the fuel cycle facilities, Spent Fuel Cooling Time, Thermal Reprocessing Introduction Date, and in core and Out-of-core TRU Inventory Requirements for recycling technology. An optimization scheme of the nuclear fuel cycle is proposed. Optimization criteria and metrics of interest for different stakeholders in the fuel cycle (economics, waste management, environmental impact, etc.) are utilized for two different optimization techniques (linear and stochastic). Preliminary results covering single and multi-variable and single and multi-objective optimization demonstrate the viability of the optimization scheme. (authors)

  19. Decentred comparative research: Context sensitive analysis of maternal health care.

    PubMed

    Wrede, Sirpa; Benoit, Cecilia; Bourgeault, Ivy Lynn; van Teijlingen, Edwin R; Sandall, Jane; De Vries, Raymond G

    2006-12-01

    Cross-national comparison is an important tool for health care research, but too often those who use this method fail to consider important inter-national differences in the social organisation of health care and in the relationship between health care practices and social experience. In this article we make the case for a context-sensitive and reflexive analysis of health care that allows researchers to understand the important ways that health care systems and practices are situated in time and place. Our approach--decentred comparative research--addresses the often unacknowledged ethnocentrism of traditional comparative research. Decentred cross-national research is a method that draws on the socially situated and distributed expertise of an international research team to develop key concepts and research questions. We used the decentred method to fashion a multilevel framework that used the meso level of organisation (i.e., health care organisations, professional groups and other concrete organisations) as an analytical starting point in our international study of maternity care in eight countries. Our method departs from traditional comparative health systems research that is most often conducted at the macro level. Our approach will help researchers develop new and socially robust knowledge about health care. PMID:16962695

  20. Sensitivity analysis of near-infrared functional lymphatic imaging

    NASA Astrophysics Data System (ADS)

    Weiler, Michael; Kassis, Timothy; Dixon, J. Brandon

    2012-06-01

    Near-infrared imaging of lymphatic drainage of injected indocyanine green (ICG) has emerged as a new technology for clinical imaging of lymphatic architecture and quantification of vessel function, yet the imaging capabilities of this approach have yet to be quantitatively characterized. We seek to quantify its capabilities as a diagnostic tool for lymphatic disease. Imaging is performed in a tissue phantom for sensitivity analysis and in hairless rats for in vivo testing. To demonstrate the efficacy of this imaging approach to quantifying immediate functional changes in lymphatics, we investigate the effects of a topically applied nitric oxide (NO) donor glyceryl trinitrate ointment. Premixing ICG with albumin induces greater fluorescence intensity, with the ideal concentration being 150 μg/mL ICG and 60 g/L albumin. ICG fluorescence can be detected at a concentration of 150 μg/mL as deep as 6 mm with our system, but spatial resolution deteriorates below 3 mm, skewing measurements of vessel geometry. NO treatment slows lymphatic transport, which is reflected in increased transport time, reduced packet frequency, reduced packet velocity, and reduced effective contraction length. NIR imaging may be an alternative to invasive procedures measuring lymphatic function in vivo in real time.

  1. Sensitivity analysis of imaging geometries for prostate diffuse optical tomography

    NASA Astrophysics Data System (ADS)

    Zhou, Xiaodong; Zhu, Timothy C.

    2008-02-01

    Endoscopic and interstitial diffuse optical tomography have been studied in clinical investigations for imaging prostate tissues, yet, there is no comprehensive comparison of how these two imaging geometries affect the quality of the reconstruction images. In this study, the effect of imaging geometry is investigated by comparing the cross-section of the Jacobian sensitivity matrix and reconstructed images for three-dimensional mathematical phantoms. Next, the effect of source-detector configurations and number of measurements in both geometries is evaluated using singular value analysis. The amount of information contained for each source-detector configuration and different number of measurements are compared. Further, the effect of different measurements strategies for 3D endoscopic and interstitial tomography is examined. The pros and cons of using the in-plane measurements and off-plane measurements are discussed. Results showed that the reconstruction in the interstitial geometry outperforms the endoscopic geometry when deeper anomalies are present. Eight sources 8 detectors and 6 sources 12 detectors are sufficient for 2D reconstruction with endoscopic and interstitial geometry respectively. For a 3D problem, the quantitative accuracy in the interstitial geometry is significantly improved using off-plane measurements but only slightly in the endoscopic geometry.

  2. A sensitive transcriptome analysis method that can detect unknown transcripts

    PubMed Central

    Fukumura, Ryutaro; Takahashi, Hirokazu; Saito, Toshiyuki; Tsutsumi, Yoko; Fujimori, Akira; Sato, Shinji; Tatsumi, Kouichi; Araki, Ryoko; Abe, Masumi

    2003-01-01

    We have developed an AFLP-based gene expression profiling method called ‘high coverage expression profiling’ (HiCEP) analysis. By making improvements to the selective PCR technique we have reduced the rate of false positive peaks to ∼4% and consequently the number of peaks, including overlapping peaks, has been markedly decreased. As a result we can determine the relationship between peaks and original transcripts unequivocally. This will make it practical to prepare a database of all peaks, allowing gene assignment without having to isolate individual peaks. This precise selection also enables us to easily clone peaks of interest and predict the corresponding gene for each peak in some species. The procedure is highly reproducible and sensitive enough to detect even a 1.2-fold difference in gene expression. Most importantly, the low false positive rate enables us to analyze gene expression with wide coverage by means of four instead of six nucleotide recognition site restriction enzymes for fingerprinting mRNAs. Therefore, the method detects 70–80% of all transcripts, including non-coding transcripts, unknown and known genes. Moreover, the method requires no sequence information and so is applicable even to eukaryotes for which there is no genome information available. PMID:12907746

  3. Assessing direct analysis in real-time-mass spectrometry (DART-MS) for the rapid identification of additives in food packaging.

    PubMed

    Ackerman, L K; Noonan, G O; Begley, T H

    2009-12-01

    The ambient ionization technique direct analysis in real time (DART) was characterized and evaluated for the screening of food packaging for the presence of packaging additives using a benchtop mass spectrometer (MS). Approximate optimum conditions were determined for 13 common food-packaging additives, including plasticizers, anti-oxidants, colorants, grease-proofers, and ultraviolet light stabilizers. Method sensitivity and linearity were evaluated using solutions and characterized polymer samples. Additionally, the response of a model additive (di-ethyl-hexyl-phthalate) was examined across a range of sample positions, DART, and MS conditions (temperature, voltage and helium flow). Under optimal conditions, molecular ion (M+H+) was the major ion for most additives. Additive responses were highly sensitive to sample and DART source orientation, as well as to DART flow rates, temperatures, and MS inlet voltages, respectively. DART-MS response was neither consistently linear nor quantitative in this setting, and sensitivity varied by additive. All additives studied were rapidly identified in multiple food-packaging materials by DART-MS/MS, suggesting this technique can be used to screen food packaging rapidly. However, method sensitivity and quantitation requires further study and improvement. PMID:19753496

  4. Analysis of Cyberbullying Sensitivity Levels of High School Students and Their Perceived Social Support Levels

    ERIC Educational Resources Information Center

    Akturk, Ahmet Oguz

    2015-01-01

    Purpose: The purpose of this paper is to determine the cyberbullying sensitivity levels of high school students and their perceived social supports levels, and analyze the variables that predict cyberbullying sensitivity. In addition, whether cyberbullying sensitivity levels and social support levels differed according to gender was also…

  5. Atomic Data for X-ray Spectrum Synthesis: Sensitivity Analysis and Consequences for Spectral Fitting

    NASA Astrophysics Data System (ADS)

    Kallman, Timothy R.

    2006-09-01

    A great deal of work has been devoted to the accumulation of accurate quantities describing atomic processes for use in analysis of astrophysical spectra. But in many situations of interest the interpretation of a quantity which is observed, such as a line flux, depends on the results of a modeling- or spectrum synthesis code. The results of such a code depends in turn on many atomic rates or cross sections, and the sensitivity of the observable quantity on the various rates and cross sections may be non-linear and if so cannot easily be derived analytically. In such cases the most practical approach to understanding the sensitivity of observables to atomic cross sections is to perform numerical experiments, by calculating models with various rates perturbed by random (but known) factors. In addition, it is useful to compare the results of such experiments with some sample observations, in order to focus attention on the rates which are of the greatest relevance to real observations. I will present some attempts to carry out this program, focussing on two sample datasets taken with the Chandra HETG. I will discuss the sensitivity of synthetic spectra to atomic data affecting ionization balance, temperature, and line opacity or emissivity, and discuss the implications for the ultimate goal of inferring astrophysical parameters. In addition, I will discuss the likely effects on the ionization balance and spectrum synthesis due to the adoption of some recent calculations of dielectronic recombination rate coefficients.

  6. Sensitivity analysis of standardization procedures in drought indices to varied input data selections

    NASA Astrophysics Data System (ADS)

    Liu, Yi; Ren, Liliang; Hong, Yang; Zhu, Ye; Yang, Xiaoli; Yuan, Fei; Jiang, Shanhu

    2016-07-01

    Reasonable input data selection is of great significance for accurate computation of drought indices. In this study, a comprehensive comparison is conducted on the sensitivity of two commonly used standardization procedures (SP) in drought indices to datasets, namely the probability distribution based SP and the self-calibrating Palmer SP. The standardized Palmer drought index (SPDI) and the self-calibrating Palmer drought severity index (SC-PDSI) are selected as representatives of the two SPs, respectively. Using meteorological observations (1961-2012) in the Yellow River basin, 23 sub-datasets with a length of 30 years are firstly generated with the moving window method. Then we use the whole time series and 23 sub-datasets to compute two indices separately, and compare their spatiotemporal differences, as well as performances in capturing drought areas. Finally, a systematic investigation in term of changing climatic conditions and varied parameters in each SP is conducted. Results show that SPDI is less sensitive to data selection than SC-PDSI. SPDI series derived from different datasets are highly correlated, and consistent in drought area characterization. Sensitivity analysis shows that among the three parameters in the generalized extreme value (GEV) distribution, SPDI is most sensitive to changes in the scale parameter, followed by location and shape parameters. For SC-PDSI, its inconsistent behaviors among different datasets are primarily induced by the self-calibrated duration factors (p and q). In addition, it is found that the introduction of the self-calibrating procedure for duration factors further aggravates the dependence of drought index on input datasets compared with original empirical algorithm that Palmer uses, making SC-PDSI more sensitive to variations in data sample. This study clearly demonstrate the impacts of dataset selection on sensitivity of drought index computation, which has significant implications for proper usage of drought

  7. Beta-carotene suppression of benzophenone-sensitized lipid peroxidation in hexane through additional chain-breaking activities

    NASA Astrophysics Data System (ADS)

    Cvetković, Dragan; Marković, Dejan

    2011-01-01

    The aim of this work is to estimate the antioxidant activity of β-carotene in the presence of two different mixtures of phospholipids in hexane solution, under continuous UV-irradiation from three different ranges (UV-A, UV-B, and UV-C). β-Carotene is employed to control lipid peroxidation process generated by UV-irradiation, in the presence and in the absence of selected photosensitizer, benzophenone, by scavenging the involved, created free radicals. The results show that β-carotene undergoes to a substantial, probably structural dependent destruction (bleaching), highly dependent on UV-photons energy input, more expressed in the presence than in the absence of benzophenone. The additional bleaching is synchronized with the further increase in β-carotene antioxidant activity in the presence of benzophenone, implying the same cause: increase in (phospholipids peroxidation) chain-breaking activities.

  8. Recent advances in the sensitivity analysis for the thermomechanical postbuckling of composite panels

    NASA Technical Reports Server (NTRS)

    Noor, Ahmed K.

    1995-01-01

    Three recent developments in the sensitivity analysis for thermomechanical postbuckling response of composite panels are reviewed. The three developments are: (1) effective computational procedure for evaluating hierarchical sensitivity coefficients of the various response quantities with respect to the different laminate, layer, and micromechanical characteristics; (2) application of reduction methods to the sensitivity analysis of the postbuckling response; and (3) accurate evaluation of the sensitivity coefficients to transverse shear stresses. Sample numerical results are presented to demonstrate the effectiveness of the computational procedures presented. Some of the future directions for research on sensitivity analysis for the thermomechanical postbuckling response of composite and smart structures are outlined.

  9. Sensitivity analysis using computer calculus: A nuclear waste isolation application

    SciTech Connect

    Oblow, E.M.; Pin, F.G.; Wright, R.Q.

    1986-09-01

    An automated procedure for performing large-scale sensitivity studies based on the use of computer calculus is presented. The procedure is embodied in a FORTRAN precompiler called GRESS, which automatically processes computer models adding derivative-taking capabilities to the normal calculated results. The theory and applicability of the GRESS codes are described and tested against a major geohydrological modeling problem. The SWENT nuclear waste repository modeling code is used as the basis for these studies. Results for a test problem involving groundwater flow in the vicinity of the Richton Salt Dome are discussed in detail. Sensitivity results are compared with analytical, perturbation, and alternate sensitivity approaches to the problem. Five-place accuracy in these sensitivity results is verified for all cases in which the effects of nonlinearities are made sufficiently small. Conclusions are drawn as to the applicability of GRESS in the problem studied and for more general large-scale modeling sensitivity studies.

  10. Design of 3-D Nacelle near Flat-Plate Wing Using Multiblock Sensitivity Analysis (ADOS)

    NASA Technical Reports Server (NTRS)

    Eleshaky, Mohamed E.; Baysal, Oktay

    1994-01-01

    One of the major design tasks involved in reducing aircraft drag is the integration of the engine nacelles and airframe. With this impetus, nacelle shapes with and without the presence of a flat-plate wing nearby were optimized. This also served as a demonstration of the 3-D version of the recently developed aerodynamic design optimization methodology using sensitivity analysis, ADOS. The required flow analyses were obtained by solving the three-dimensional, compressible, thin-layer Navier-Stokes equations using an implicit, upwind-biased, finite volume scheme. The sensitivity analyses were performed using the preconditioned version of the SADD scheme (sensitivity analysis on domain decomposition). In addition to demonstrating the present method's capability for automatic optimization, the results offered some insight into two important issues related to optimizing the shapes of multicomponent configurations in close proximity. First, inclusion of the mutual interference between the components resulted in a different shape as opposed to shaping an isolated component. Secondly, exclusion of the viscous effects compromised not only the flow physics but also the optimized shapes even for isolated components.

  11. Robustness and period sensitivity analysis of minimal models for biochemical oscillators

    PubMed Central

    Caicedo-Casso, Angélica; Kang, Hye-Won; Lim, Sookkyung; Hong, Christian I.

    2015-01-01

    Biological systems exhibit numerous oscillatory behaviors from calcium oscillations to circadian rhythms that recur daily. These autonomous oscillators contain complex feedbacks with nonlinear dynamics that enable spontaneous oscillations. The detailed nonlinear dynamics of such systems remains largely unknown. In this paper, we investigate robustness and dynamical differences of five minimal systems that may underlie fundamental molecular processes in biological oscillatory systems. Bifurcation analyses of these five models demonstrate an increase of oscillatory domains with a positive feedback mechanism that incorporates a reversible reaction, and dramatic changes in dynamics with small modifications in the wiring. Furthermore, our parameter sensitivity analysis and stochastic simulations reveal different rankings of hierarchy of period robustness that are determined by the number of sensitive parameters or network topology. In addition, systems with autocatalytic positive feedback loop are shown to be more robust than those with positive feedback via inhibitory degradation regardless of noise type. We demonstrate that robustness has to be comprehensively assessed with both parameter sensitivity analysis and stochastic simulations. PMID:26267886

  12. An example uncertainty and sensitivity analysis at the Horonobe site for performance assessment calculations.

    SciTech Connect

    James, Scott Carlton

    2004-08-01

    Given pre-existing Groundwater Modeling System (GMS) models of the Horonobe Underground Research Laboratory (URL) at both the regional and site scales, this work performs an example uncertainty analysis for performance assessment (PA) applications. After a general overview of uncertainty and sensitivity analysis techniques, the existing GMS sitescale model is converted to a PA model of the steady-state conditions expected after URL closure. This is done to examine the impact of uncertainty in site-specific data in conjunction with conceptual model uncertainty regarding the location of the Oomagari Fault. In addition, a quantitative analysis of the ratio of dispersive to advective forces, the F-ratio, is performed for stochastic realizations of each conceptual model. All analyses indicate that accurate characterization of the Oomagari Fault with respect to both location and hydraulic conductivity is critical to PA calculations. This work defines and outlines typical uncertainty and sensitivity analysis procedures and demonstrates them with example PA calculations relevant to the Horonobe URL.

  13. Sensitivity analysis of water quality for Delhi stretch of the River Yamuna, India.

    PubMed

    Parmar, D L; Keshari, Ashok K

    2012-03-01

    Simulation models are used to aid the decision makers about water pollution control and management in river systems. However, uncertainty of model parameters affects the model predictions and hence the pollution control decision. Therefore, it often is necessary to identify the model parameters that significantly affect the model output uncertainty prior to or as a supplement to model application to water pollution control and planning problems. In this study, sensitivity analysis, as a tool for uncertainty analysis was carried out to assess the sensitivity of water quality to (a) model parameters (b) pollution abatement measures such as wastewater treatment, waste discharge and flow augmentation from upstream reservoir. In addition, sensitivity analysis for the "best practical solution" was carried out to help the decision makers in choosing an appropriate option. The Delhi stretch of the river Yamuna was considered as a case study. The QUAL2E model is used for water quality simulation. The results obtained indicate that parameters K(1) (deoxygenation constant) and K(3) (settling oxygen demand), which is the rate of biochemical decomposition of organic matter and rate of BOD removal by settling, respectively, are the most sensitive parameters for the considered river stretch. Different combinations of variations in K(1) and K(2) also revealed similar results for better understanding of inter-dependability of K(1) and K(2). Also, among the pollution abatement methods, the change (perturbation) in wastewater treatment level at primary, secondary, tertiary, and advanced has the greatest effect on the uncertainty of the simulated dissolved oxygen and biochemical oxygen demand concentrations. PMID:21544505

  14. A meta-analysis on pain sensitivity in self-injury.

    PubMed

    Koenig, J; Thayer, J F; Kaess, M

    2016-06-01

    Individuals engaging in self-injurious behavior (SIB) frequently report absence of pain during acts of SIB. While altered pain sensitivity is discussed as a risk factor for the engagement in SIB, results have been mixed with considerable variance across reported effect sizes, in particular with respect to the effect of co-morbid psychopathology. The present meta-analysis aimed to summarize the current evidence on pain sensitivity in individuals engaging in SIB and to identify covariates of altered pain processing. Three databases were searched without restrictions. Additionally a hand search was performed and reference lists of included studies were checked for potential studies eligible for inclusion. Thirty-two studies were identified after screening 720 abstracts by two independent reviewers. Studies were included if they reported (i) an empirical investigation, in (ii) humans, including a sample of individuals engaging in (iii) SIB and a group of (iv) healthy controls, (v) receiving painful stimulation. Random-effects meta-analysis was performed on three pain-related outcomes (pain threshold, pain tolerance, pain intensity) and several population- and study-level covariates (i.e. age, sex, clinical etiology) were subjected to meta-regression. Meta-analysis revealed significant main effects associated with medium to large effect sizes for all included outcomes. Individuals engaging in SIB show greater pain threshold and tolerance and report less pain intensity compared to healthy controls. Clinical etiology and age are significant covariates of pain sensitivity in individuals engaging in SIB, such that pain threshold is further increased in borderline personality disorder compared to non-suicidal self-injury. Mechanisms underlying altered pain sensitivity are discussed. PMID:26964517

  15. Distributed Evaluation of Local Sensitivity Analysis (DELSA), with application to hydrologic models

    NASA Astrophysics Data System (ADS)

    Rakovec, O.; Hill, M. C.; Clark, M. P.; Weerts, A. H.; Teuling, A. J.; Uijlenhoet, R.

    2014-01-01

    This paper presents a hybrid local-global sensitivity analysis method termed the Distributed Evaluation of Local Sensitivity Analysis (DELSA), which is used here to identify important and unimportant parameters and evaluate how model parameter importance changes as parameter values change. DELSA uses derivative-based "local" methods to obtain the distribution of parameter sensitivity across the parameter space, which promotes consideration of sensitivity analysis results in the context of simulated dynamics. This work presents DELSA, discusses how it relates to existing methods, and uses two hydrologic test cases to compare its performance with the popular global, variance-based Sobol' method. The first test case is a simple nonlinear reservoir model with two parameters. The second test case involves five alternative "bucket-style" hydrologic models with up to 14 parameters applied to a medium-sized catchment (200 km2) in the Belgian Ardennes. Results show that in both examples, Sobol' and DELSA identify similar important and unimportant parameters, with DELSA enabling more detailed insight at much lower computational cost. For example, in the real-world problem the time delay in runoff is the most important parameter in all models, but DELSA shows that for about 20% of parameter sets it is not important at all and alternative mechanisms and parameters dominate. Moreover, the time delay was identified as important in regions producing poor model fits, whereas other parameters were identified as more important in regions of the parameter space producing better model fits. The ability to understand how parameter importance varies through parameter space is critical to inform decisions about, for example, additional data collection and model development. The ability to perform such analyses with modest computational requirements provides exciting opportunities to evaluate complicated models as well as many alternative models.

  16. Sorption of redox-sensitive elements: critical analysis

    SciTech Connect

    Strickert, R.G.

    1980-12-01

    The redox-sensitive elements (Tc, U, Np, Pu) discussed in this report are of interest to nuclear waste management due to their long-lived isotopes which have a potential radiotoxic effect on man. In their lower oxidation states these elements have been shown to be highly adsorbed by geologic materials occurring under reducing conditions. Experimental research conducted in recent years, especially through the Waste Isolation Safety Assessment Program (WISAP) and Waste/Rock Interaction Technology (WRIT) program, has provided extensive information on the mechanisms of retardation. In general, ion-exchange probably plays a minor role in the sorption behavior of cations of the above three actinide elements. Formation of anionic complexes of the oxidized states with common ligands (OH/sup -/, CO/sup - -//sub 3/) is expected to reduce adsorption by ion exchange further. Pertechnetate also exhibits little ion-exchange sorption by geologic media. In the reduced (IV) state, all of the elements are highly charged and it appears that they form a very insoluble compound (oxide, hydroxide, etc.) or undergo coprecipitation or are incorporated into minerals. The exact nature of the insoluble compounds and the effect of temperature, pH, pe, other chemical species, and other parameters are currently being investigated. Oxidation states other than Tc (IV,VII), U(IV,VI), Np(IV,V), and Pu(IV,V) are probably not important for the geologic repository environment expected, but should be considered especially when extreme conditions exist (radiation, temperature, etc.). Various experimental techniques such as oxidation-state analysis of tracer-level isotopes, redox potential measurement and control, pH measurement, and solid phase identification have been used to categorize the behavior of the various valence states.

  17. Taxonicity of anxiety sensitivity: a multi-national analysis.

    PubMed

    Bernstein, Amit; Zvolensky, Michael J; Kotov, Roman; Arrindell, Willem A; Taylor, Steven; Sandin, Bonifacio; Cox, Brian J; Stewart, Sherry H; Bouvard, Martine; Cardenas, Samuel Jurado; Eifert, Georg H; Schmidt, Norman B

    2006-01-01

    Taxometric coherent cut kinetic analyses were used to test the latent structure of anxiety sensitivity in samples from North America (Canada and United States of America), France, Mexico, Spain, and The Netherlands (total n = 2741). Anxiety sensitivity was indexed by the 36-item Anxiety Sensitivity Index--Revised (ASI-R; [J. Anxiety Disord. 12(5) (1998) 463]). Four manifest indicators of anxiety sensitivity were constructed using the ASI-R: fear of cardiovascular symptoms, fear of respiratory symptoms, fear of publicly observable anxiety reactions, and fear of mental incapacitation. Results from MAXCOV-HITMAX, internal consistency tests, analyses of simulated Monte Carlo data, and a MAMBAC external consistency test indicated that the latent structure of anxiety sensitivity was taxonic in each of the samples. The estimated base rate of the anxiety sensitivity taxon differed slightly between nations, ranging from 11.5 to 21.5%. In general, the four ASI-R based manifest indicators showed high levels of validity. Results are discussed in relation to the conceptual understanding of anxiety sensitivity, with specific emphasis on theoretical refinement of the construct. PMID:16325111

  18. Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system

    PubMed Central

    Lumen, Annie; McNally, Kevin; George, Nysia; Fisher, Jeffrey W.; Loizou, George D.

    2015-01-01

    A deterministic biologically based dose-response model for the thyroidal system in a near-term pregnant woman and the fetus was recently developed to evaluate quantitatively thyroid hormone perturbations. The current work focuses on conducting a quantitative global sensitivity analysis on this complex model to identify and characterize the sources and contributions of uncertainties in the predicted model output. The workflow and methodologies suitable for computationally expensive models, such as the Morris screening method and Gaussian Emulation processes, were used for the implementation of the global sensitivity analysis. Sensitivity indices, such as main, total and interaction effects, were computed for a screened set of the total thyroidal system descriptive model input parameters. Furthermore, a narrower sub-set of the most influential parameters affecting the model output of maternal thyroid hormone levels were identified in addition to the characterization of their overall and pair-wise parameter interaction quotients. The characteristic trends of influence in model output for each of these individual model input parameters over their plausible ranges were elucidated using Gaussian Emulation processes. Through global sensitivity analysis we have gained a better understanding of the model behavior and performance beyond the domains of observation by the simultaneous variation in model inputs over their range of plausible uncertainties. The sensitivity analysis helped identify parameters that determine the driving mechanisms of the maternal and fetal iodide kinetics, thyroid function and their interactions, and contributed to an improved understanding of the system modeled. We have thus demonstrated the use and application of global sensitivity analysis for a biologically based dose-response model for sensitive life-stages such as pregnancy that provides richer information on the model and the thyroidal system modeled compared to local sensitivity analysis

  19. Decoupled direct method for sensitivity analysis in combustion kinetics

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, Krishnan

    1987-01-01

    An efficient, decoupled direct method for calculating the first order sensitivity coefficients of homogeneous, batch combustion kinetic rate equations is presented. In this method the ordinary differential equations for the sensitivity coefficients are solved separately from , but sequentially with, those describing the combustion chemistry. The ordinary differential equations for the thermochemical variables are solved using an efficient, implicit method (LSODE) that automatically selects the steplength and order for each solution step. The solution procedure for the sensitivity coefficients maintains accuracy and stability by using exactly the same steplengths and numerical approximations. The method computes sensitivity coefficients with respect to any combination of the initial values of the thermochemical variables and the three rate constant parameters for the chemical reactions. The method is illustrated by application to several simple problems and, where possible, comparisons are made with exact solutions and those obtained by other techniques.

  20. Computational aspects of sensitivity calculations in linear transient structural analysis

    NASA Technical Reports Server (NTRS)

    Greene, W. H.; Haftka, R. T.

    1991-01-01

    The calculation of sensitivities of displacements, velocities, accelerations, and stresses in linear, structural, and transient response problems is studied. Several existing sensitivity calculation methods and two new methods are compared for three example problems. Approximation vectors such as vibration mode shapes are used to reduce the dimensionality of the finite model. To be computationally practical in large-order problems, the overall finite difference methods must use the approximation vectors from the original design in the analyses of the perturbed models. This was found to result in poor convergence of stress sensitivities in several cases. Two semianalytical techniques are developed to overcome this poor convergence. Both new methods result in very good convergence of the stress sensitivities; the computational cost is much less than would result if the vibration modes were recalculated and then used in an overall finite difference method.

  1. Validation analysis of probabilistic models of dietary exposure to food additives.

    PubMed

    Gilsenan, M B; Thompson, R L; Lambe, J; Gibney, M J

    2003-10-01

    The validity of a range of simple conceptual models designed specifically for the estimation of food additive intakes using probabilistic analysis was assessed. Modelled intake estimates that fell below traditional conservative point estimates of intake and above 'true' additive intakes (calculated from a reference database at brand level) were considered to be in a valid region. Models were developed for 10 food additives by combining food intake data, the probability of an additive being present in a food group and additive concentration data. Food intake and additive concentration data were entered as raw data or as a lognormal distribution, and the probability of an additive being present was entered based on the per cent brands or the per cent eating occasions within a food group that contained an additive. Since the three model components assumed two possible modes of input, the validity of eight (2(3)) model combinations was assessed. All model inputs were derived from the reference database. An iterative approach was employed in which the validity of individual model components was assessed first, followed by validation of full conceptual models. While the distribution of intake estimates from models fell below conservative intakes, which assume that the additive is present at maximum permitted levels (MPLs) in all foods in which it is permitted, intake estimates were not consistently above 'true' intakes. These analyses indicate the need for more complex models for the estimation of food additive intakes using probabilistic analysis. Such models should incorporate information on market share and/or brand loyalty. PMID:14555358

  2. Sensitivity Analysis and Neutron Fluence Adjustment for VVER-1000 Rpv

    NASA Astrophysics Data System (ADS)

    Belousov, S.; Ilieva, Kr.; Kirilova, D.

    2003-06-01

    Adjustment of the neutron fluence at the VVER-1000 RPV inner wall has been carried out. For the purpose of this adjustment the neutron flux response sensitivity to the main parameters of calculation uncertainty has been calculated. The obtained sensitivities, the parameters uncertainty and activity measurement data of iron, copper and niobium detectors positioned behind the RPV of Kozloduy NPP Unit 5 have been used in this adjustment.

  3. Sensitivity analysis of the age-structured malaria transmission model

    NASA Astrophysics Data System (ADS)

    Addawe, Joel M.; Lope, Jose Ernie C.

    2012-09-01

    We propose an age-structured malaria transmission model and perform sensitivity analyses to determine the relative importance of model parameters to disease transmission. We subdivide the human population into two: preschool humans (below 5 years) and the rest of the human population (above 5 years). We then consider two sets of baseline parameters, one for areas of high transmission and the other for areas of low transmission. We compute the sensitivity indices of the reproductive number and the endemic equilibrium point with respect to the two sets of baseline parameters. Our simulations reveal that in areas of either high or low transmission, the reproductive number is most sensitive to the number of bites by a female mosquito on the rest of the human population. For areas of low transmission, we find that the equilibrium proportion of infectious pre-school humans is most sensitive to the number of bites by a female mosquito. For the rest of the human population it is most sensitive to the rate of acquiring temporary immunity. In areas of high transmission, the equilibrium proportion of infectious pre-school humans and the rest of the human population are both most sensitive to the birth rate of humans. This suggests that strategies that target the mosquito biting rate on pre-school humans and those that shortens the time in acquiring immunity can be successful in preventing the spread of malaria.

  4. Sensitivity analysis of a nonlinear Newton-Krylov solver for heat transfer with phase change.

    SciTech Connect

    Henninger, Rudolph J.; Knoll, D. A.; Kothe, D. B.; Lally, B. R.

    2002-01-01

    Development of a complex metal-casting computer model requires information about how varying the problem parameters affects the results (metal flow and solidification). For example, we would like to know how the last point to solidify or the cooling rate at a given location changes when the physical properties of the metal, boundary conditions, or mold geometry are changed. As a preliminary step towards a complete sensitivity analysis of a three-dimensional casting simulation, we examine a one-dimensional version of a metal-alloy phase-change conductive-heat-transfer model by means of Automatic Differentiation (AD). This non-linear 'Jacobian-free' method is a combination of an outer Newton-based iteration and an inner conjugate gradient-like (Krylov) iteration. The implicit solution algorithm has enthalpy as the dependent variable from which temperatures are determined. We examine the sensitivities of the difference between an exact analytical solution for the final temperature and that produced by this algorithm to the problem parameters. In all there are 17 parameters (12 physical constants such as liquid density, heat capacity, and thermal conductivity, 2 initial and boundary condition parameters, the final solution time, and 2 algorithm tolerances). We apply AD in the forward and reverse mode and verify the sensitivities by means of finite differences. In general, the finite-difference method requires at least N+1 computer runs to determine sensitivities for N problem parameters. By forward and reverse, we mean the direction through the solution and in time and space in which the derivative values are obtained. The forward mode is typically more efficient for determining the sensitivity of many responses to one or a few parameters, while the reverse mode is better suited for sensitivities of one or a few responses with respect to many parameters. The sensitivities produced by all the methods agreed to at least three significant figures. The forward and reverse

  5. Solar-powered/fuel-assisted Rankine cycle power and cooling system - Sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Lior, N.; Koai, K.

    1984-11-01

    The subject of this analysis is a solar power/cooling system based on a novel hybrid steam Rankine cycle. Steam is generated by the use of solar energy collected at about 100 C, and it is then superheated to about 600 C in a fossil-fuel-fired superheater. The addition of about 20-26 percent of energy as fuel doubles the power cycle's efficiency as compared to organic fluid Rankine cycles operating at similar collector temperatures. A sensitivity analysis of the system's performance to the size and type of its components was performed by a transient (hourly) computer simulation over the month of August in two representative climatic regions (Washington, D.C. and Phoenix, Ariz.), and led to the description of a system configuration which provides optimal energy performance. The newly designed turbine's predicted efficiency is seen to be essentially invariant with system configuration, and has a monthly average value of about 73 percent.

  6. Sensitivity analysis of climatic parameters for sky classification

    NASA Astrophysics Data System (ADS)

    Li, D. H. W.; Tang, H. L.; Cheung, K. L.; Lee, E. W. M.; Cheng, C. C. K.

    2011-10-01

    Climatic variables are frequently used as weighting factors to indicate the degree of clearness for interpreting sky patterns. However, such important parameters are not always widely available and their criteria to define a sky condition are not clear-cut. In addition, certain variables may be more effective than the others in terms of sky identification. This paper studies the capability of various daylight parameters, namely zenith luminance, global, direct-beam and sky-diffuse illuminance, and solar altitude for categorizing the 15 International Commission on Illumination (CIE) standard skies. A new form of artificial neural networks called probabilistic neural network (PNN) which is a powerful technique for pattern recognition was used for the analysis. The findings suggested that the PNN is an appropriate tool when a number of climatic parameters of various criteria for differentiating sky standards are employed, and the ratio of zenith luminance to diffuse illuminance ( L z/ D v) and solar altitude ( α s) are respectively the most and the least significant input parameters for discriminating between the 15 CIE skies.

  7. Effect of sodium acetate additive in successive ionic layer adsorption and reaction on the performance of CdS quantum-dot-sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Liu, I.-Ping; Chen, Liang-Yih; Lee, Yuh-Lang

    2016-09-01

    Sodium acetate (NaAc) is utilized as an additive in cationic precursors of the successive ionic layer adsorption and reaction (SILAR) process to fabricate CdS quantum-dot (QD)-sensitized photoelectrodes. The effects of the NaAc concentration on the deposition rate and distribution of QDs in mesoporous TiO2 films, as well as on the performance of CdS-sensitized solar cells are studied. The experimental results show that the presence of NaAc can significantly accelerate the deposition of CdS, improve the QD distribution across photoelectrodes, and thereby, increase the performance of solar cells. These results are mainly attributed to the pH-elevation effect of NaAc to the cationic precursors which increases the electrostatic interaction of the TiO2 film to cadmium ions. The light-to-energy conversion efficiency of the CdS-sensitized solar cell increases with increasing concentration of the NaAc and approaches a maximum value (3.11%) at 0.05 M NaAc. Additionally, an ionic exchange is carried out on the photoelectrode to transform the deposited CdS into CdS1-xSex ternary QDs. The light-absorption range of the photoelectrode is extended and an exceptional power conversion efficiency of 4.51% is achieved due to this treatment.

  8. An analytical approach to grid sensitivity analysis for NACA four-digit wing sections

    NASA Technical Reports Server (NTRS)

    Sadrehaghighi, I.; Tiwari, S. N.

    1992-01-01

    Sensitivity analysis in computational fluid dynamics with emphasis on grids and surface parameterization is described. An interactive algebraic grid-generation technique is employed to generate C-type grids around NACA four-digit wing sections. An analytical procedure is developed for calculating grid sensitivity with respect to design parameters of a wing section. A comparison of the sensitivity with that obtained using a finite difference approach is made. Grid sensitivity with respect to grid parameters, such as grid-stretching coefficients, are also investigated. Using the resultant grid sensitivity, aerodynamic sensitivity is obtained using the compressible two-dimensional thin-layer Navier-Stokes equations.

  9. Thermal-Hydrological Sensitivity Analysis of Underground Coal Gasification

    SciTech Connect

    Buscheck, T A; Hao, Y; Morris, J P; Burton, E A

    2009-10-05

    . Specifically, we conducted a parameter sensitivity analysis of the influence of thermal and hydrological properties of the host coal, caprock, and bedrock on cavity temperature and steam production.

  10. Multivariate qualitative analysis of banned additives in food safety using surface enhanced Raman scattering spectroscopy

    NASA Astrophysics Data System (ADS)

    He, Shixuan; Xie, Wanyi; Zhang, Wei; Zhang, Liqun; Wang, Yunxia; Liu, Xiaoling; Liu, Yulong; Du, Chunlei

    2015-02-01

    A novel strategy which combines iteratively cubic spline fitting baseline correction method with discriminant partial least squares qualitative analysis is employed to analyze the surface enhanced Raman scattering (SERS) spectroscopy of banned food additives, such as Sudan I dye and Rhodamine B in food, Malachite green residues in aquaculture fish. Multivariate qualitative analysis methods, using the combination of spectra preprocessing iteratively cubic spline fitting (ICSF) baseline correction with principal component analysis (PCA) and discriminant partial least squares (DPLS) classification respectively, are applied to investigate the effectiveness of SERS spectroscopy for predicting the class assignments of unknown banned food additives. PCA cannot be used to predict the class assignments of unknown samples. However, the DPLS classification can discriminate the class assignment of unknown banned additives using the information of differences in relative intensities. The results demonstrate that SERS spectroscopy combined with ICSF baseline correction method and exploratory analysis methodology DPLS classification can be potentially used for distinguishing the banned food additives in field of food safety.

  11. Multivariate qualitative analysis of banned additives in food safety using surface enhanced Raman scattering spectroscopy.

    PubMed

    He, Shixuan; Xie, Wanyi; Zhang, Wei; Zhang, Liqun; Wang, Yunxia; Liu, Xiaoling; Liu, Yulong; Du, Chunlei

    2015-02-25

    A novel strategy which combines iteratively cubic spline fitting baseline correction method with discriminant partial least squares qualitative analysis is employed to analyze the surface enhanced Raman scattering (SERS) spectroscopy of banned food additives, such as Sudan I dye and Rhodamine B in food, Malachite green residues in aquaculture fish. Multivariate qualitative analysis methods, using the combination of spectra preprocessing iteratively cubic spline fitting (ICSF) baseline correction with principal component analysis (PCA) and discriminant partial least squares (DPLS) classification respectively, are applied to investigate the effectiveness of SERS spectroscopy for predicting the class assignments of unknown banned food additives. PCA cannot be used to predict the class assignments of unknown samples. However, the DPLS classification can discriminate the class assignment of unknown banned additives using the information of differences in relative intensities. The results demonstrate that SERS spectroscopy combined with ICSF baseline correction method and exploratory analysis methodology DPLS classification can be potentially used for distinguishing the banned food additives in field of food safety. PMID:25300041

  12. 7 CFR 91.38 - Additional fees for appeal of analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Additional fees for appeal of analysis. 91.38 Section 91.38 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... for laboratory service that appears in this paragraph. The new fiscal year for Science and...

  13. 7 CFR 91.38 - Additional fees for appeal of analysis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Additional fees for appeal of analysis. 91.38 Section 91.38 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... for laboratory service that appears in this paragraph. The new fiscal year for Science and...

  14. How to assess the Efficiency and "Uncertainty" of Global Sensitivity Analysis?

    NASA Astrophysics Data System (ADS)

    Haghnegahdar, Amin; Razavi, Saman

    2016-04-01

    Sensitivity analysis (SA) is an important paradigm for understanding model behavior, characterizing uncertainty, improving model calibration, etc. Conventional "global" SA (GSA) approaches are rooted in different philosophies, resulting in different and sometime conflicting and/or counter-intuitive assessment of sensitivity. Moreover, most global sensitivity techniques are highly computationally demanding to be able to generate robust and stable sensitivity metrics over the entire model response surface. Accordingly, a novel sensitivity analysis method called Variogram Analysis of Response Surfaces (VARS) is introduced to overcome the aforementioned issues. VARS uses the Variogram concept to efficiently provide a comprehensive assessment of global sensitivity across a range of scales within the parameter space. Based on the VARS principles, in this study we present innovative ideas to assess (1) the efficiency of GSA algorithms and (2) the level of confidence we can assign to a sensitivity assessment. We use multiple hydrological models with different levels of complexity to explain the new ideas.

  15. Stimulation of terrestrial ecosystem carbon storage by nitrogen addition: a meta-analysis.

    PubMed

    Yue, Kai; Peng, Yan; Peng, Changhui; Yang, Wanqin; Peng, Xin; Wu, Fuzhong

    2016-01-01

    Elevated nitrogen (N) deposition alters the terrestrial carbon (C) cycle, which is likely to feed back to further climate change. However, how the overall terrestrial ecosystem C pools and fluxes respond to N addition remains unclear. By synthesizing data from multiple terrestrial ecosystems, we quantified the response of C pools and fluxes to experimental N addition using a comprehensive meta-analysis method. Our results showed that N addition significantly stimulated soil total C storage by 5.82% ([2.47%, 9.27%], 95% CI, the same below) and increased the C contents of the above- and below-ground parts of plants by 25.65% [11.07%, 42.12%] and 15.93% [6.80%, 25.85%], respectively. Furthermore, N addition significantly increased aboveground net primary production by 52.38% [40.58%, 65.19%] and litterfall by 14.67% [9.24%, 20.38%] at a global scale. However, the C influx from the plant litter to the soil through litter decomposition and the efflux from the soil due to microbial respiration and soil respiration showed insignificant responses to N addition. Overall, our meta-analysis suggested that N addition will increase soil C storage and plant C in both above- and below-ground parts, indicating that terrestrial ecosystems might act to strengthen as a C sink under increasing N deposition. PMID:26813078

  16. Stimulation of terrestrial ecosystem carbon storage by nitrogen addition: a meta-analysis

    PubMed Central

    Yue, Kai; Peng, Yan; Peng, Changhui; Yang, Wanqin; Peng, Xin; Wu, Fuzhong

    2016-01-01

    Elevated nitrogen (N) deposition alters the terrestrial carbon (C) cycle, which is likely to feed back to further climate change. However, how the overall terrestrial ecosystem C pools and fluxes respond to N addition remains unclear. By synthesizing data from multiple terrestrial ecosystems, we quantified the response of C pools and fluxes to experimental N addition using a comprehensive meta-analysis method. Our results showed that N addition significantly stimulated soil total C storage by 5.82% ([2.47%, 9.27%], 95% CI, the same below) and increased the C contents of the above- and below-ground parts of plants by 25.65% [11.07%, 42.12%] and 15.93% [6.80%, 25.85%], respectively. Furthermore, N addition significantly increased aboveground net primary production by 52.38% [40.58%, 65.19%] and litterfall by 14.67% [9.24%, 20.38%] at a global scale. However, the C influx from the plant litter to the soil through litter decomposition and the efflux from the soil due to microbial respiration and soil respiration showed insignificant responses to N addition. Overall, our meta-analysis suggested that N addition will increase soil C storage and plant C in both above- and below-ground parts, indicating that terrestrial ecosystems might act to strengthen as a C sink under increasing N deposition. PMID:26813078

  17. Stimulation of terrestrial ecosystem carbon storage by nitrogen addition: a meta-analysis

    NASA Astrophysics Data System (ADS)

    Yue, Kai; Peng, Yan; Peng, Changhui; Yang, Wanqin; Peng, Xin; Wu, Fuzhong

    2016-01-01

    Elevated nitrogen (N) deposition alters the terrestrial carbon (C) cycle, which is likely to feed back to further climate change. However, how the overall terrestrial ecosystem C pools and fluxes respond to N addition remains unclear. By synthesizing data from multiple terrestrial ecosystems, we quantified the response of C pools and fluxes to experimental N addition using a comprehensive meta-analysis method. Our results showed that N addition significantly stimulated soil total C storage by 5.82% ([2.47%, 9.27%], 95% CI, the same below) and increased the C contents of the above- and below-ground parts of plants by 25.65% [11.07%, 42.12%] and 15.93% [6.80%, 25.85%], respectively. Furthermore, N addition significantly increased aboveground net primary production by 52.38% [40.58%, 65.19%] and litterfall by 14.67% [9.24%, 20.38%] at a global scale. However, the C influx from the plant litter to the soil through litter decomposition and the efflux from the soil due to microbial respiration and soil respiration showed insignificant responses to N addition. Overall, our meta-analysis suggested that N addition will increase soil C storage and plant C in both above- and below-ground parts, indicating that terrestrial ecosystems might act to strengthen as a C sink under increasing N deposition.

  18. Local sensitivity analysis for inverse problems solved by singular value decomposition

    USGS Publications Warehouse

    Hill, M.C.; Nolan, B.T.

    2010-01-01

    regression based on the range of singular values. Identifiability statistic results varied based on the number of SVD parameters included. Identifiability statistics calculated for four SVD parameters indicate the same three most important process-model parameters as CSS/PCC (WFC1, WFC2, and BD2), but the order differed. Additionally, the identifiability statistic showed that BD1 was almost as dominant as WFC1. The CSS/PCC analysis showed that this results from its high correlation with WCF1 (-0.94), and not its individual sensitivity. Such distinctions, combined with analysis of how high correlations and(or) sensitivities result from the constructed model, can produce important insights into, for example, the use of sensitivity analysis to design monitoring networks. In conclusion, the statistics considered identified similar important parameters. They differ because (1) with CSS/PCC can be more awkward because sensitivity and interdependence are considered separately and (2) identifiability requires consideration of how many SVD parameters to include. A continuing challenge is to understand how these computationally efficient methods compare with computationally demanding global methods like Markov-Chain Monte Carlo given common nonlinear processes and the often even more nonlinear models.

  19. Increasing the sensitivity of PCR detection in bovine preputial smegma spiked with Tritrichomonas foetus by the addition of agar and resin.

    PubMed

    Chen, X G; Li, J

    2001-07-01

    Methods for the extraction of DNA from the preputial smegma of cattle infected with Tritrichomonas foetus for the purposes of polymerase chain reaction (PCR) detection are usually time-consuming, relatively insensitive and require hazardous chemicals. In order to solve these problems, we have developed a rapid, sensitive and harmless method to extract quality DNA from preputial smegma spiked with T. foetus. Results indicate that the addition of 5% Chelex-100 resin and 0.05% agar solution to the spiked smegma before the process of DNA extraction by the boiling method can significantly increase the sensitivity of PCR detection. This improved method may be suitable for routine DNA extraction for the diagnosis of cattle and even human trichomoniasis by PCR. PMID:11484853

  20. Global sensitivity analysis in control-augmented structural synthesis

    NASA Technical Reports Server (NTRS)

    Bloebaum, Christina L.

    1989-01-01

    In this paper, an integrated approach to structural/control design is proposed in which variables in both the passive (structural) and active (control) disciplines of an optimization process are changed simultaneously. The global sensitivity equation (GSE) method of Sobieszczanski-Sobieski (1988) is used to obtain the behavior sensitivity derivatives necessary for the linear approximations used in the parallel multidisciplinary synthesis problem. The GSE allows for the decoupling of large systems into smaller subsystems and thus makes it possible to determine the local sensitivities of each subsystem's outputs to its inputs and parameters. The advantages in using the GSE method are demonstrated using a finite-element representation of a truss structure equipped with active lateral displacement controllers, which is undergoing forced vibration.

  1. On an Additive Semigraphoid Model for Statistical Networks With Application to Pathway Analysis

    PubMed Central

    Li, Bing; Chun, Hyonho; Zhao, Hongyu

    2014-01-01

    We introduce a nonparametric method for estimating non-gaussian graphical models based on a new statistical relation called additive conditional independence, which is a three-way relation among random vectors that resembles the logical structure of conditional independence. Additive conditional independence allows us to use one-dimensional kernel regardless of the dimension of the graph, which not only avoids the curse of dimensionality but also simplifies computation. It also gives rise to a parallel structure to the gaussian graphical model that replaces the precision matrix by an additive precision operator. The estimators derived from additive conditional independence cover the recently introduced nonparanormal graphical model as a special case, but outperform it when the gaussian copula assumption is violated. We compare the new method with existing ones by simulations and in genetic pathway analysis. PMID:26401064

  2. Analysis of occupational accidents: prevention through the use of additional technical safety measures for machinery

    PubMed Central

    Dźwiarek, Marek; Latała, Agata

    2016-01-01

    This article presents an analysis of results of 1035 serious and 341 minor accidents recorded by Poland's National Labour Inspectorate (PIP) in 2005–2011, in view of their prevention by means of additional safety measures applied by machinery users. Since the analysis aimed at formulating principles for the application of technical safety measures, the analysed accidents should bear additional attributes: the type of machine operation, technical safety measures and the type of events causing injuries. The analysis proved that the executed tasks and injury-causing events were closely connected and there was a relation between casualty events and technical safety measures. In the case of tasks consisting of manual feeding and collecting materials, the injuries usually occur because of the rotating motion of tools or crushing due to a closing motion. Numerous accidents also happened in the course of supporting actions, like removing pollutants, correcting material position, cleaning, etc. PMID:26652689

  3. Reducing the matrix effects in chemical analysis: fusion of isotope dilution and standard addition methods

    NASA Astrophysics Data System (ADS)

    Pagliano, Enea; Meija, Juris

    2016-04-01

    The combination of isotope dilution and mass spectrometry has become an ubiquitous tool of chemical analysis. Often perceived as one of the most accurate methods of chemical analysis, it is not without shortcomings. Current isotope dilution equations are not capable of fully addressing one of the key problems encountered in chemical analysis: the possible effect of sample matrix on measured isotope ratios. The method of standard addition does compensate for the effect of sample matrix by making sure that all measured solutions have identical composition. While it is impossible to attain such condition in traditional isotope dilution, we present equations which allow for matrix-matching between all measured solutions by fusion of isotope dilution and standard addition methods.

  4. Analysis of occupational accidents: prevention through the use of additional technical safety measures for machinery.

    PubMed

    Dźwiarek, Marek; Latała, Agata

    2016-01-01

    This article presents an analysis of results of 1035 serious and 341 minor accidents recorded by Poland's National Labour Inspectorate (PIP) in 2005-2011, in view of their prevention by means of additional safety measures applied by machinery users. Since the analysis aimed at formulating principles for the application of technical safety measures, the analysed accidents should bear additional attributes: the type of machine operation, technical safety measures and the type of events causing injuries. The analysis proved that the executed tasks and injury-causing events were closely connected and there was a relation between casualty events and technical safety measures. In the case of tasks consisting of manual feeding and collecting materials, the injuries usually occur because of the rotating motion of tools or crushing due to a closing motion. Numerous accidents also happened in the course of supporting actions, like removing pollutants, correcting material position, cleaning, etc. PMID:26652689

  5. Variability-based global sensitivity analysis of circuit response

    NASA Astrophysics Data System (ADS)

    Opalski, Leszek J.

    2014-11-01

    The research problem of interest to this paper is: how to determine efficiently and objectively the most and the least influential parameters of a multimodule electronic system - given the system model f and the module parameter variation ranges. The author investigates if existing generic global sensitivity methods are applicable for electronic circuit design, even if they were developed (and successfully applied) in quite distant engineering areas. A photodiode detector analog front-end system response time is used to reveal capability of the selected global sensitivity approaches under study.

  6. Fractal Analysis of Stress Sensitivity of Permeability in Porous Media

    NASA Astrophysics Data System (ADS)

    Tan, Xiao-Hua; Li, Xiao-Ping; Liu, Jian-Yi; Zhang, Lie-Hui; Cai, Jianchao

    2015-12-01

    A permeability model for porous media considering the stress sensitivity is derived based on mechanics of materials and the fractal characteristics of solid cluster size distribution. The permeability of porous media considering the stress sensitivity is related to solid cluster fractal dimension, solid cluster fractal tortuosity dimension, solid cluster minimum diameter and solid cluster maximum diameter, Young's modulus, Poisson's ratio, as well as power index. Every parameter has clear physical meaning without the use of empirical constants. The model predictions of permeability show good agreement with those obtained by the available experimental expression. The proposed model may be conducible to a better understanding of the mechanism for flow in elastic porous media.

  7. A Most Probable Point-Based Method for Reliability Analysis, Sensitivity Analysis and Design Optimization

    NASA Technical Reports Server (NTRS)

    Hou, Gene J.-W.; Gumbert, Clyde R.; Newman, Perry A.

    2004-01-01

    A major step in a most probable point (MPP)-based method for reliability analysis is to determine the MPP. This is usually accomplished by using an optimization search algorithm. The optimal solutions associated with the MPP provide measurements related to safety probability. This study focuses on two commonly used approximate probability integration methods; i.e., the Reliability Index Approach (RIA) and the Performance Measurement Approach (PMA). Their reliability sensitivity equations are first derived in this paper, based on the derivatives of their respective optimal solutions. Examples are then provided to demonstrate the use of these derivatives for better reliability analysis and Reliability-Based Design Optimization (RBDO).

  8. A Most Probable Point-Based Method for Reliability Analysis, Sensitivity Analysis and Design Optimization

    NASA Technical Reports Server (NTRS)

    Hou, Gene J.-W; Newman, Perry A. (Technical Monitor)

    2004-01-01

    A major step in a most probable point (MPP)-based method for reliability analysis is to determine the MPP. This is usually accomplished by using an optimization search algorithm. The minimum distance associated with the MPP provides a measurement of safety probability, which can be obtained by approximate probability integration methods such as FORM or SORM. The reliability sensitivity equations are derived first in this paper, based on the derivatives of the optimal solution. Examples are provided later to demonstrate the use of these derivatives for better reliability analysis and reliability-based design optimization (RBDO).

  9. Analysis of JPSS J1 VIIRS Polarization Sensitivity Using the NIST T-SIRCUS

    NASA Technical Reports Server (NTRS)

    McIntire, Jeffrey W.; Young, James B.; Moyer, David; Waluschka, Eugene; Oudrari, Hassan; Xiong, Xiaoxiong

    2015-01-01

    The polarization sensitivity of the Joint Polar Satellite System (JPSS) J1 Visible Infrared Imaging Radiometer Suite (VIIRS) measured pre-launch using a broadband source was observed to be larger than expected for many reflective bands. Ray trace modeling predicted that the observed polarization sensitivity was the result of larger diattenuation at the edges of the focal plane filter spectral bandpass. Additional ground measurements were performed using a monochromatic source (the NIST T-SIRCUS) to input linearly polarized light at a number of wavelengths across the bandpass of two VIIRS spectral bands and two scan angles. This work describes the data processing, analysis, and results derived from the T-SIRCUS measurements, comparing them with broadband measurements. Results have shown that the observed degree of linear polarization, when weighted by the sensor's spectral response function, is generally larger on the edges and smaller in the center of the spectral bandpass, as predicted. However, phase angle changes in the center of the bandpass differ between model and measurement. Integration of the monochromatic polarization sensitivity over wavelength produced results consistent with the broadband source measurements, for all cases considered.

  10. Sensitivity Analysis Applied to Atomic Data Used for X-ray Spectrum Synthesis

    NASA Technical Reports Server (NTRS)

    Kallman, Tim

    2006-01-01

    A great deal of work has been devoted to the accumulation of accurate quantities describing atomic processes for use in analysis of astrophysical spectra. But in many situations of interest the interpretation of a quantity which is observed, such as a line flux, depends on the results of a modeling- or spectrum synthesis code. The results of such a code depends in turn 011 many atomic rates or cross sections, and the sensitivity of the observable quantity on the various rates and cross sections may be non-linear and if so cannot easily be derived analytically. In such cases the most practical approach to understanding the sensitivity of observables to atomic cross sections is to perform numerical experiments, by calculating models with various rates perturbed by random (but known) factors. In addition, it is useful to compare the results of such experiments with some sample observations, in order to focus attention on the rates which are of the greatest relevance to real observations. In this paper I will present some attempts to carry out this program, focussing on two sample datasets taken with the Chandra HETG. I will discuss the sensitivity of synthetic spectra to atomic data affecting ionization balance, temperature, and line opacity or emissivity, and discuss the implications for the ultimate goal of inferring astrophysical parameters.

  11. Sensitivity Analysis Applied to Atomic Data Used for X-ray Spectrum Synthesis

    NASA Technical Reports Server (NTRS)

    Kallman, Tim

    2006-01-01

    A great deal of work has been devoted to the accumulation of accurate quantities describing atomic processes for use in analysis of astrophysical spectra. But in many situations of interest the interpretation of a quantity which is observed, such as a line flux, depends on the results of a modeling- or spectrum synthesis code. The results of such a code depends in turn on many atomic rates or cross sections, and the sensitivity of the observable quantity on the various rates and cross sections may be non-linear and if so cannot easily be derived analytically. In such cases the most practical approach to understanding the sensitivity of observables to atomic cross sections is to perform numerical experiments, by calculating models with various rates perturbed by random (but known) factors. In addition, it is useful to compare the results of such experiments with some sample observations, in order to focus attention on the rates which are of the greatest relevance to real observations. In this paper I will present some attempts to carry out this program, focussing on two sample datasets taken with the Chandra HETG. I will discuss the sensitivity of synthetic spectra to atomic data affecting ionization balance, temperature, and line opacity or emissivity, and discuss the implications for the ultimate goal of inferring astrophysical parameters.

  12. Large-scale transient sensitivity analysis of a radiation damaged bipolar junction transistor.

    SciTech Connect

    Hoekstra, Robert John; Gay, David M.; Bartlett, Roscoe Ainsworth; Phipps, Eric Todd

    2007-11-01

    Automatic differentiation (AD) is useful in transient sensitivity analysis of a computational simulation of a bipolar junction transistor subject to radiation damage. We used forward-mode AD, implemented in a new Trilinos package called Sacado, to compute analytic derivatives for implicit time integration and forward sensitivity analysis. Sacado addresses element-based simulation codes written in C++ and works well with forward sensitivity analysis as implemented in the Trilinos time-integration package Rythmos. The forward sensitivity calculation is significantly more efficient and robust than finite differencing.

  13. A Sensitivity Analysis of a Thin Film Conductivity Estimation Method

    SciTech Connect

    McMasters, Robert L; Dinwiddie, Ralph Barton

    2010-01-01

    An analysis method was developed for determining the thermal conductivity of a thin film on a substrate of known thermal properties using the flash diffusivity method. In order to determine the thermal conductivity of the film using this method, the volumetric heat capacity of the film must be known, as determined in a separate experiment. Additionally, the thermal properties of the substrate must be known, including conductivity and volumetric heat capacity. The ideal conditions for the experiment are a low conductivity film adhered to a higher conductivity substrate. As the film becomes thinner with respect to the substrate or, as the conductivity of the film approaches that of the substrate, the estimation of thermal conductivity of the film becomes more difficult. The present research examines the effect of inaccuracies in the known parameters on the estimation of the parameter of interest, the thermal conductivity of the film. As such, perturbations are introduced into the other parameters in the experiment, which are assumed to be known, to find the effect on the estimated thermal conductivity of the film. A baseline case is established with the following parameters: Substrate thermal conductivity 1.0 W/m-K Substrate volumetric heat capacity 106 J/m3-K Substrate thickness 0.8 mm Film thickness 0.2 mm Film volumetric heat capacity 106 J/m3-K Film thermal conductivity 0.01 W/m-K Convection coefficient 20 W/m2-K Magnitude of heat absorbed during the flash 1000 J/m2 Each of these parameters, with the exception of film thermal conductivity, the parameter of interest, is varied from its baseline value, in succession, and placed into a synthetic experimental data file. Each of these data files is individually analyzed by the program to determine the effect on the estimated film conductivity, thus quantifying the vulnerability of the method to measurement errors.

  14. Survey of sampling-based methods for uncertainty and sensitivity analysis.

    SciTech Connect

    Johnson, Jay Dean; Helton, Jon Craig; Sallaberry, Cedric J. PhD.; Storlie, Curt B. (Colorado State University, Fort Collins, CO)

    2006-06-01

    Sampling-based methods for uncertainty and sensitivity analysis are reviewed. The following topics are considered: (1) Definition of probability distributions to characterize epistemic uncertainty in analysis inputs, (2) Generation of samples from uncertain analysis inputs, (3) Propagation of sampled inputs through an analysis, (4) Presentation of uncertainty analysis results, and (5) Determination of sensitivity analysis results. Special attention is given to the determination of sensitivity analysis results, with brief descriptions and illustrations given for the following procedures/techniques: examination of scatterplots, correlation analysis, regression analysis, partial correlation analysis, rank transformations, statistical tests for patterns based on gridding, entropy tests for patterns based on gridding, nonparametric regression analysis, squared rank differences/rank correlation coefficient test, two dimensional Kolmogorov-Smirnov test, tests for patterns based on distance measures, top down coefficient of concordance, and variance decomposition.

  15. Sensitivity Analysis for Hierarchical Models Employing "t" Level-1 Assumptions.

    ERIC Educational Resources Information Center

    Seltzer, Michael; Novak, John; Choi, Kilchan; Lim, Nelson

    2002-01-01

    Examines the ways in which level-1 outliers can impact the estimation of fixed effects and random effects in hierarchical models (HMs). Also outlines and illustrates the use of Markov Chain Monte Carlo algorithms for conducting sensitivity analyses under "t" level-1 assumptions, including algorithms for settings in which the degrees of freedom at…

  16. Fecal bacteria source characterization and sensitivity analysis of SWAT 2005

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soil and Water Assessment Tool (SWAT) version 2005 includes a microbial sub-model to simulate fecal bacteria transport at the watershed scale. The objectives of this study were to demonstrate methods to characterize fecal coliform bacteria (FCB) source loads and to assess the model sensitivity t...

  17. Intelligence and Interpersonal Sensitivity: A Meta-Analysis

    ERIC Educational Resources Information Center

    Murphy, Nora A.; Hall, Judith A.

    2011-01-01

    A meta-analytic review investigated the association between general intelligence and interpersonal sensitivity. The review involved 38 independent samples with 2988 total participants. There was a highly significant small-to-medium effect for intelligence measures to be correlated with decoding accuracy (r=0.19, p less than 0.001). Significant…

  18. Diagnosis of Middle Atmosphere Climate Sensitivity by the Climate Feedback Response Analysis Method

    NASA Technical Reports Server (NTRS)

    Zhu, Xun; Yee, Jeng-Hwa; Cai, Ming; Swartz, William H.; Coy, Lawrence; Aquila, Valentina; Talaat, Elsayed R.

    2014-01-01

    We present a new method to diagnose the middle atmosphere climate sensitivity by extending the Climate Feedback-Response Analysis Method (CFRAM) for the coupled atmosphere-surface system to the middle atmosphere. The Middle atmosphere CFRAM (MCFRAM) is built on the atmospheric energy equation per unit mass with radiative heating and cooling rates as its major thermal energy sources. MCFRAM preserves the CFRAM unique feature of an additive property for which the sum of all partial temperature changes due to variations in external forcing and feedback processes equals the observed temperature change. In addition, MCFRAM establishes a physical relationship of radiative damping between the energy perturbations associated with various feedback processes and temperature perturbations associated with thermal responses. MCFRAM is applied to both measurements and model output fields to diagnose the middle atmosphere climate sensitivity. It is found that the largest component of the middle atmosphere temperature response to the 11-year solar cycle (solar maximum vs. solar minimum) is directly from the partial temperature change due to the variation of the input solar flux. Increasing CO2 always cools the middle atmosphere with time whereas partial temperature change due to O3 variation could be either positive or negative. The partial temperature changes due to different feedbacks show distinctly different spatial patterns. The thermally driven globally averaged partial temperature change due to all radiative processes is approximately equal to the observed temperature change, ranging from 0.5 K near 70 km from the near solar maximum to the solar minimum.

  19. Integrated multidisciplinary design optimization using discrete sensitivity analysis for geometrically complex aeroelastic configurations

    NASA Astrophysics Data System (ADS)

    Newman, James Charles, III

    1997-10-01

    practical interest, the sensitivity analysis and shape optimization has been performed for several two- and three-dimensional cases. In twodimensions, an initially symmetric NACA-0012 airfoil and a high-lift multielement airfoil were examined. For the three-dimensional configurations, an initially rectangular wing with uniform NACA-0012 cross-sections was optimized; in addition, a complete Boeing 747-200 aircraft was studied. Furthermore, the current study also examines the effect of inconsistency in the order of spatial accuracy between the nonlinear fluid and linear shape sensitivity equations. The second step was to develop a computationally efficient, high-fidelity, integrated static aeroelastic analysis procedure. To accomplish this, a structural analysis code was coupled with the aforementioned unstructured grid aerodynamic analysis solver. The use of an unstructured grid scheme for the aerodynamic analysis enhances the interaction compatibility with the wing structure. The structural analysis utilizes finite elements to model the wing so that accurate structural deflections may be obtained. In the current work, parameters have been introduced to control the interaction of the computational fluid dynamics and structural analyses; these control parameters permit extremely efficient static aeroelastic computations. To demonstrate and evaluate this procedure, static aeroelastic analysis results for a flexible wing in low subsonic, high subsonic (subcritical), transonic (supercritical), and supersonic flow conditions are presented.

  20. Non-invasive baroreflex sensitivity assessment using wavelet transfer function-based time-frequency analysis.

    PubMed

    Keissar, K; Maestri, R; Pinna, G D; La Rovere, M T; Gilad, O

    2010-07-01

    A novel approach for the estimation of baroreflex sensitivity (BRS) is introduced based on time-frequency analysis of the transfer function (TF). The TF method (TF-BRS) is a well-established non-invasive technique which assumes stationarity. This condition is difficult to meet, especially in cardiac patients. In this study, the classical TF was replaced with a wavelet transfer function (WTF) and the classical coherence was replaced with wavelet transform coherence (WTC), adding the time domain as an additional degree of freedom with dynamic error estimation. Error analysis and comparison between WTF-BRS and TF-BRS were performed using simulated signals with known transfer function and added noise. Similar comparisons were performed for ECG and blood pressure signals, in the supine position, of 19 normal subjects, 44 patients with a history of previous myocardial infarction (MI) and 45 patients with chronic heart failure. This yielded an excellent linear association (R > 0.94, p < 0.001) for time-averaged WTF-BRS, validating the new method as consistent with a known method. The additional advantage of dynamic analysis of coherence and TF estimates was illustrated in two physiological examples of supine rest and change of posture showing the evolution of BRS synchronized with its error estimations and sympathovagal balance. PMID:20585147

  1. Coupled Aerodynamic and Structural Sensitivity Analysis of a High-Speed Civil Transport

    NASA Technical Reports Server (NTRS)

    Mason, B. H.; Walsh, J. L.

    2001-01-01

    An objective of the High Performance Computing and Communication Program at the NASA Langley Research Center is to demonstrate multidisciplinary shape and sizing optimization of a complete aerospace vehicle configuration by using high-fidelity, finite-element structural analysis and computational fluid dynamics aerodynamic analysis. In a previous study, a multi-disciplinary analysis system for a high-speed civil transport was formulated to integrate a set of existing discipline analysis codes, some of them computationally intensive, This paper is an extension of the previous study, in which the sensitivity analysis for the coupled aerodynamic and structural analysis problem is formulated and implemented. Uncoupled stress sensitivities computed with a constant load vector in a commercial finite element analysis code are compared to coupled aeroelastic sensitivities computed by finite differences. The computational expense of these sensitivity calculation methods is discussed.

  2. Sensitivity Analysis of Left Ventricle with Dilated Cardiomyopathy in Fluid Structure Simulation

    PubMed Central

    Chan, Bee Ting; Abu Osman, Noor Azuan; Lim, Einly; Chee, Kok Han; Abdul Aziz, Yang Faridah; Abed, Amr Al; Lovell, Nigel H.; Dokos, Socrates

    2013-01-01

    Dilated cardiomyopathy (DCM) is the most common myocardial disease. It not only leads to systolic dysfunction but also diastolic deficiency. We sought to investigate the effect of idiopathic and ischemic DCM on the intraventricular fluid dynamics and myocardial wall mechanics using a 2D axisymmetrical fluid structure interaction model. In addition, we also studied the individual effect of parameters related to DCM, i.e. peak E-wave velocity, end systolic volume, wall compliance and sphericity index on several important fluid dynamics and myocardial wall mechanics variables during ventricular filling. Intraventricular fluid dynamics and myocardial wall deformation are significantly impaired under DCM conditions, being demonstrated by low vortex intensity, low flow propagation velocity, low intraventricular pressure difference (IVPD) and strain rates, and high-end diastolic pressure and wall stress. Our sensitivity analysis results showed that flow propagation velocity substantially decreases with an increase in wall stiffness, and is relatively independent of preload at low-peak E-wave velocity. Early IVPD is mainly affected by the rate of change of the early filling velocity and end systolic volume which changes the ventriculo:annular ratio. Regional strain rate, on the other hand, is significantly correlated with regional stiffness, and therefore forms a useful indicator for myocardial regional ischemia. The sensitivity analysis results enhance our understanding of the mechanisms leading to clinically observable changes in patients with DCM. PMID:23825628

  3. Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation.

    PubMed

    Chan, Bee Ting; Abu Osman, Noor Azuan; Lim, Einly; Chee, Kok Han; Abdul Aziz, Yang Faridah; Abed, Amr Al; Lovell, Nigel H; Dokos, Socrates

    2013-01-01

    Dilated cardiomyopathy (DCM) is the most common myocardial disease. It not only leads to systolic dysfunction but also diastolic deficiency. We sought to investigate the effect of idiopathic and ischemic DCM on the intraventricular fluid dynamics and myocardial wall mechanics using a 2D axisymmetrical fluid structure interaction model. In addition, we also studied the individual effect of parameters related to DCM, i.e. peak E-wave velocity, end systolic volume, wall compliance and sphericity index on several important fluid dynamics and myocardial wall mechanics variables during ventricular filling. Intraventricular fluid dynamics and myocardial wall deformation are significantly impaired under DCM conditions, being demonstrated by low vortex intensity, low flow propagation velocity, low intraventricular pressure difference (IVPD) and strain rates, and high-end diastolic pressure and wall stress. Our sensitivity analysis results showed that flow propagation velocity substantially decreases with an increase in wall stiffness, and is relatively independent of preload at low-peak E-wave velocity. Early IVPD is mainly affected by the rate of change of the early filling velocity and end systolic volume which changes the ventriculo:annular ratio. Regional strain rate, on the other hand, is significantly correlated with regional stiffness, and therefore forms a useful indicator for myocardial regional ischemia. The sensitivity analysis results enhance our understanding of the mechanisms leading to clinically observable changes in patients with DCM. PMID:23825628

  4. Capillary ion-exchange chromatography with nanogram sensitivity for the analysis of monoclonal antibodies.

    PubMed

    Rea, Jennifer C; Freistadt, Benny S; McDonald, Daniel; Farnan, Dell; Wang, Yajun Jennifer

    2015-12-11

    Ion-exchange chromatography (IEC) is widely used for profiling the charge heterogeneity of proteins, including monoclonal antibodies (mAbs). Despite good resolving power and robustness, ionic strength-based ion-exchange separations are generally product specific and can be time consuming to develop. In addition, conventional analytical scale ion-exchange separations require tens of micrograms of mAbs for each injection, amounts that are often unavailable in sample-limited applications. We report the development of a capillary IEC (c-IEC) methodology for the analysis of nanogram amounts of mAb charge variants. Several key modifications were made to a commercially available liquid chromatography system to perform c-IEC for charge variant analysis of mAbs with nanogram sensitivity. We demonstrate the method for multiple monoclonal antibodies, including antibody fragments, on different columns from different manufacturers. Relative standard deviations of <10% were achieved for relative peak areas of main peak, acidic and basic regions, which are common regions of interest for quantifying monoclonal antibody charge variants using IEC. The results herein demonstrate the excellent sensitivity of this c-IEC characterization method, which can be used for analyzing charge variants in sample-limited applications, such as early-stage candidate screening and in vivo studies. PMID:26596872

  5. Long vs. short-term energy storage:sensitivity analysis.

    SciTech Connect

    Schoenung, Susan M. (Longitude 122 West, Inc., Menlo Park, CA); Hassenzahl, William V. (,Advanced Energy Analysis, Piedmont, CA)

    2007-07-01

    This report extends earlier work to characterize long-duration and short-duration energy storage technologies, primarily on the basis of life-cycle cost, and to investigate sensitivities to various input assumptions. Another technology--asymmetric lead-carbon capacitors--has also been added. Energy storage technologies are examined for three application categories--bulk energy storage, distributed generation, and power quality--with significant variations in discharge time and storage capacity. Sensitivity analyses include cost of electricity and natural gas, and system life, which impacts replacement costs and capital carrying charges. Results are presented in terms of annual cost, $/kW-yr. A major variable affecting system cost is hours of storage available for discharge.

  6. Sensitive glow discharge ion source for aerosol and gas analysis

    DOEpatents

    Reilly, Peter T. A.

    2007-08-14

    A high sensitivity glow discharge ion source system for analyzing particles includes an aerodynamic lens having a plurality of constrictions for receiving an aerosol including at least one analyte particle in a carrier gas and focusing the analyte particles into a collimated particle beam. A separator separates the carrier gas from the analyte particle beam, wherein the analyte particle beam or vapors derived from the analyte particle beam are selectively transmitted out of from the separator. A glow discharge ionization source includes a discharge chamber having an entrance orifice for receiving the analyte particle beam or analyte vapors, and a target electrode and discharge electrode therein. An electric field applied between the target electrode and discharge electrode generates an analyte ion stream from the analyte vapors, which is directed out of the discharge chamber through an exit orifice, such as to a mass spectrometer. High analyte sensitivity is obtained by pumping the discharge chamber exclusively through the exit orifice and the entrance orifice.

  7. Overview of Sensitivity Analysis and Shape Optimization for Complex Aerodynamic Configurations

    NASA Technical Reports Server (NTRS)

    Newman, Perry A.; Newman, James C., III; Barnwell, Richard W.; Taylor, Arthur C., III; Hou, Gene J.-W.

    1998-01-01

    This paper presents a brief overview of some of the more recent advances in steady aerodynamic shape-design sensitivity analysis and optimization, based on advanced computational fluid dynamics. The focus here is on those methods particularly well- suited to the study of geometrically complex configurations and their potentially complex associated flow physics. When nonlinear state equations are considered in the optimization process, difficulties are found in the application of sensitivity analysis. Some techniques for circumventing such difficulties are currently being explored and are included here. Attention is directed to methods that utilize automatic differentiation to obtain aerodynamic sensitivity derivatives for both complex configurations and complex flow physics. Various examples of shape-design sensitivity analysis for unstructured-grid computational fluid dynamics algorithms are demonstrated for different formulations of the sensitivity equations. Finally, the use of advanced, unstructured-grid computational fluid dynamics in multidisciplinary analyses and multidisciplinary sensitivity analyses within future optimization processes is recommended and encouraged.

  8. Overview of Sensitivity Analysis and Shape Optimization for Complex Aerodynamic Configurations

    NASA Technical Reports Server (NTRS)

    Newman, James C., III; Taylor, Arthur C., III; Barnwell, Richard W.; Newman, Perry A.; Hou, Gene J.-W.

    1999-01-01

    This paper presents a brief overview of some of the more recent advances in steady aerodynamic shape-design sensitivity analysis and optimization, based on advanced computational fluid dynamics (CFD). The focus here is on those methods particularly well-suited to the study of geometrically complex configurations and their potentially complex associated flow physics. When nonlinear state equations are considered in the optimization process, difficulties are found in the application of sensitivity analysis. Some techniques for circumventing such difficulties are currently being explored and are included here. Attention is directed to methods that utilize automatic differentiation to obtain aerodynamic sensitivity derivatives for both complex configurations and complex flow physics. Various examples of shape-design sensitivity analysis for unstructured-grid CFD algorithms are demonstrated for different formulations of the sensitivity equations. Finally, the use of advanced, unstructured-grid CFDs in multidisciplinary analyses and multidisciplinary sensitivity analyses within future optimization processes is recommended and encouraged.

  9. Probability density adjoint for sensitivity analysis of the Mean of Chaos

    SciTech Connect

    Blonigan, Patrick J. Wang, Qiqi

    2014-08-01

    Sensitivity analysis, especially adjoint based sensitivity analysis, is a powerful tool for engineering design which allows for the efficient computation of sensitivities with respect to many parameters. However, these methods break down when used to compute sensitivities of long-time averaged quantities in chaotic dynamical systems. This paper presents a new method for sensitivity analysis of ergodic chaotic dynamical systems, the density adjoint method. The method involves solving the governing equations for the system's invariant measure and its adjoint on the system's attractor manifold rather than in phase-space. This new approach is derived for and demonstrated on one-dimensional chaotic maps and the three-dimensional Lorenz system. It is found that the density adjoint computes very finely detailed adjoint distributions and accurate sensitivities, but suffers from large computational costs.

  10. Demasking the integrated value of discharge - Advanced sensitivity analysis on the components of hydrological models

    NASA Astrophysics Data System (ADS)

    Guse, Björn; Pfannerstill, Matthias; Gafurov, Abror; Fohrer, Nicola; Gupta, Hoshin

    2016-04-01

    The hydrologic response variable most often used in sensitivity analysis is discharge which provides an integrated value of all catchment processes. The typical sensitivity analysis evaluates how changes in the model parameters affect the model output. However, due to discharge being the aggregated effect of all hydrological processes, the sensitivity signal of a certain model parameter can be strongly masked. A more advanced form of sensitivity analysis would be achieved if we could investigate how the sensitivity of a certain modelled process variable relates to the changes in a parameter. Based on this, the controlling parameters for different hydrological components could be detected. Towards this end, we apply the approach of temporal dynamics of parameter sensitivity (TEDPAS) to calculate the daily sensitivities for different model outputs with the FAST method. The temporal variations in parameter dominance are then analysed for both the modelled hydrological components themselves, and also for the rates of change (derivatives) in the modelled hydrological components. The daily parameter sensitivities are then compared with the modelled hydrological components using regime curves. Application of this approach shows that when the corresponding modelled process is investigated instead of discharge, we obtain both an increased indication of parameter sensitivity, and also a clear pattern showing how the seasonal patterns of parameter dominance change over time for each hydrological process. By relating these results with the model structure, we can see that the sensitivity of model parameters is influenced by the function of the parameter. While capacity parameters show more sensitivity to the modelled hydrological component, flux parameters tend to have a higher sensitivity to rates of change in the modelled hydrological component. By better disentangling the information hidden in the discharge values, we can use sensitivity analyses to obtain a clearer signal

  11. Sensitivity analysis of eigenvalues for an electro-hydraulic servomechanism

    NASA Astrophysics Data System (ADS)

    Stoia-Djeska, M.; Safta, C. A.; Halanay, A.; Petrescu, C.

    2012-11-01

    Electro-hydraulic servomechanisms (EHSM) are important components of flight control systems and their role is to control the movement of the flying control surfaces in response to the movement of the cockpit controls. As flight-control systems, the EHSMs have a fast dynamic response, a high power to inertia ratio and high control accuracy. The paper is devoted to the study of the sensitivity for an electro-hydraulic servomechanism used for an aircraft aileron action. The mathematical model of the EHSM used in this paper includes a large number of parameters whose actual values may vary within some ranges of uncertainty. It consists in a nonlinear ordinary differential equation system composed by the mass and energy conservation equations, the actuator movement equations and the controller equation. In this work the focus is on the sensitivities of the eigenvalues of the linearized homogeneous system, which are the partial derivatives of the eigenvalues of the state-space system with respect the parameters. These are obtained using a modal approach based on the eigenvectors of the state-space direct and adjoint systems. To calculate the eigenvalues and their sensitivity the system's Jacobian and its partial derivatives with respect the parameters are determined. The calculation of the derivative of the Jacobian matrix with respect to the parameters is not a simple task and for many situations it must be done numerically. The system stability is studied in relation with three parameters: m, the equivalent inertial load of primary control surface reduced to the actuator rod; B, the bulk modulus of oil and p a pressure supply proportionality coefficient. All the sensitivities calculated in this work are in good agreement with those obtained through recalculations.

  12. Thermal analysis of microlens formation on a sensitized gelatin layer

    SciTech Connect

    Muric, Branka; Pantelic, Dejan; Vasiljevic, Darko; Panic, Bratimir; Jelenkovic, Branislav

    2009-07-01

    We analyze a mechanism of direct laser writing of microlenses. We find that thermal effects and photochemical reactions are responsible for microlens formation on a sensitized gelatin layer. An infrared camera was used to assess the temperature distribution during the microlens formation, while the diffraction pattern produced by the microlens itself was used to estimate optical properties. The study of thermal processes enabled us to establish the correlation between thermal and optical parameters.

  13. Computational aspects of sensitivity calculations in transient structural analysis

    NASA Technical Reports Server (NTRS)

    Greene, William H.; Haftka, Raphael T.

    1988-01-01

    A key step in the application of formal automated design techniques to structures under transient loading is the calculation of sensitivities of response quantities to the design parameters. This paper considers structures with general forms of damping acted on by general transient loading and addresses issues of computational errors and computational efficiency. The equations of motion are reduced using the traditional basis of vibration modes and then integrated using a highly accurate, explicit integration technique. A critical point constraint formulation is used to place constraints on the magnitude of each response quantity as a function of time. Three different techniques for calculating sensitivities of the critical point constraints are presented. The first two are based on the straightforward application of the forward and central difference operators, respectively. The third is based on explicit differentiation of the equations of motion. Condition errors, finite difference truncation errors, and modal convergence errors for the three techniques are compared by applying them to a simple five-span-beam problem. Sensitivity results are presented for two different transient loading conditions and for both damped and undamped cases.

  14. Sensitivity Analysis and Optimization of Aerodynamic Configurations with Blend Surfaces

    NASA Technical Reports Server (NTRS)

    Thomas, A. M.; Tiwari, S. N.

    1997-01-01

    A novel (geometrical) parametrization procedure using solutions to a suitably chosen fourth order partial differential equation is used to define a class of airplane configurations. Inclusive in this definition are surface grids, volume grids, and grid sensitivity. The general airplane configuration has wing, fuselage, vertical tail and horizontal tail. The design variables are incorporated into the boundary conditions, and the solution is expressed as a Fourier series. The fuselage has circular cross section, and the radius is an algebraic function of four design parameters and an independent computational variable. Volume grids are obtained through an application of the Control Point Form method. A graphic interface software is developed which dynamically changes the surface of the airplane configuration with the change in input design variable. The software is made user friendly and is targeted towards the initial conceptual development of any aerodynamic configurations. Grid sensitivity with respect to surface design parameters and aerodynamic sensitivity coefficients based on potential flow is obtained using an Automatic Differentiation precompiler software tool ADIFOR. Aerodynamic shape optimization of the complete aircraft with twenty four design variables is performed. Unstructured and structured volume grids and Euler solutions are obtained with standard software to demonstrate the feasibility of the new surface definition.

  15. Temperature sensitivity analysis of dopingless charge-plasma transistor

    NASA Astrophysics Data System (ADS)

    Shrivastava, Vishwas; Kumar, Anup; Sahu, Chitrakant; Singh, Jawar

    2016-03-01

    The junctionless field-effect transistors (JLFETs) have shown potential to scale down in sub-10 nm regime due to simplified fabrication process and less short-channel effects (SCEs), however, sensitivity towards process parameter variation is a major concern. Therefore, in this paper, sensitivity towards temperature variation of recently proposed dopingless (DL) double-gate field-effect transistor (DGFET) and JL-DGFET is reported. Different digital and analog performance metrics were considered and compared for both devices of similar geometries. We observed that the drive current of DL-DGFET decreases with temperature, while, it increases in JL-DGFET because both devices are affected by different scattering mechanisms at higher temperature. The variation in ION and IOFF in DL-DGFET are only 0.095 μ A/K and 0.2 nA /K , respectively, while, in JL-DGFET the changes are 0.25 μ A/K and 0.34 nA /K , respectively, above room temperature. Below room temperature, it was found that the incomplete ionization effect in JL-DGFET severely affects the drive current, however, DL-DGFET remains unaffected. Hence, the proposed DL-DGFET is less sensitive towards temperature variation and can be employed for cryogenics to high temperature applications.

  16. Superconducting Accelerating Cavity Pressure Sensitivity Analysis and Stiffening

    SciTech Connect

    Rodnizki, J; Ben Aliz, Y; Grin, A; Horvitz, Z; Perry, A; Weissman, L; Davis, G Kirk; Delayen, Jean R.

    2014-12-01

    The Soreq Applied Research Accelerator Facility (SARAF) design is based on a 40 MeV 5 mA light ions superconducting RF linac. Phase-I of SARAF delivers up to 2 mA CW proton beams in an energy range of 1.5 - 4.0 MeV. The maximum beam power that we have reached is 5.7 kW. Today, the main limiting factor to reach higher ion energy and beam power is related to the HWR sensitivity to the liquid helium coolant pressure fluctuations. The HWR sensitivity to helium pressure is about 60 Hz/mbar. The cavities had been designed, a decade ago, to be soft in order to enable tuning of their novel shape. However, the cavities turned out to be too soft. In this work we found that increasing the rigidity of the cavities in the vicinity of the external drift tubes may reduce the cavity sensitivity by a factor of three. A preliminary design to increase the cavity rigidity is presented.

  17. Imaging Fourier transform spectrometer (IFTS): parametric sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Keller, Robert A.; Lomheim, Terrence S.

    2005-06-01

    Imaging Fourier transform spectrometers (IFTS) allow for very high spectral resolution hyperspectral imaging while using moderate size 2D focal plane arrays in a staring mode. This is not the case for slit scanning dispersive imaging spectrometers where spectral sampling is related to the focal plane pixel count along the spectral dimension of the 2D focal plane used in such an instrument. This can become a major issue in the longwave infrared (LWIR) where the operability and yield of highly sensitivity arrays (i.e.HgCdTe) of large dimension are generally poor. However using an IFTS introduces its own unique set of issues and tradeoffs. In this paper we develop simplified equations for describing the sensitivity of an IFTS, including the effects of data windowing. These equations provide useful insights into the optical, focal plane and operational design trade space that must be considered when examining IFTS concepts aimed at a specific sensitivity and spectral resolution application. The approach is illustrated by computing the LWIR noise-equivalent spectral radiance (NESR) corresponding to the NASA Geosynchronous Imaging Fourier Transform Spectrometer (GIFTS) concept assuming a proven and reasonable noise-equivalent irradiance (NEI) capability for the focal plane.

  18. Uncertainty analysis of the use of a retailer fidelity card scheme in the assessment of food additive intake.

    PubMed

    McNamara, C; Mehegan, J; O'Mahony, C; Safford, B; Smith, B; Tennant, D; Buck, N; Ehrlich, V; Sardi, M; Haldemann, Y; Nordmann, H; Jasti, P R

    2011-12-01

    The feasibility of using a retailer fidelity card scheme to estimate food additive intake was investigated in an earlier study. Fidelity card survey information was combined with information provided by the retailer on levels of the food colour Sunset Yellow (E110) in the foods to estimate a daily exposure to the additive in the Swiss population. As with any dietary exposure method the fidelity card scheme is subject to uncertainties and in this paper the impact of uncertainties associated with input variables including the amounts of food purchased, the levels of E110 in food, the proportion of food purchased at the retailer, the rate of fidelity card usage, the proportion of foods consumed outside of the home and bodyweights and with systematic uncertainties was assessed using a qualitative, deterministic and probabilistic approach. An analysis of the sensitivity of the results to each of the probabilistic inputs was also undertaken. The analysis identified the key factors responsible for uncertainty within the model and demonstrated how the application of some simple probabilistic approaches can be used quantitatively to assess uncertainty. PMID:21995790

  19. Understanding hydrological flow paths in conceptual catchment models using uncertainty and sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Mockler, Eva M.; O'Loughlin, Fiachra E.; Bruen, Michael

    2016-05-01

    Increasing pressures on water quality due to intensification of agriculture have raised demands for environmental modeling to accurately simulate the movement of diffuse (nonpoint) nutrients in catchments. As hydrological flows drive the movement and attenuation of nutrients, individual hydrological processes in models should be adequately represented for water quality simulations to be meaningful. In particular, the relative contribution of groundwater and surface runoff to rivers is of interest, as increasing nitrate concentrations are linked to higher groundwater discharges. These requirements for hydrological modeling of groundwater contribution to rivers initiated this assessment of internal flow path partitioning in conceptual hydrological models. In this study, a variance based sensitivity analysis method was used to investigate parameter sensitivities and flow partitioning of three conceptual hydrological models simulating 31 Irish catchments. We compared two established conceptual hydrological models (NAM and SMARG) and a new model (SMART), produced especially for water quality modeling. In addition to the criteria that assess streamflow simulations, a ratio of average groundwater contribution to total streamflow was calculated for all simulations over the 16 year study period. As observations time-series of groundwater contributions to streamflow are not available at catchment scale, the groundwater ratios were evaluated against average annual indices of base flow and deep groundwater flow for each catchment. The exploration of sensitivities of internal flow path partitioning was a specific focus to assist in evaluating model performances. Results highlight that model structure has a strong impact on simulated groundwater flow paths. Sensitivity to the internal pathways in the models are not reflected in the performance criteria results. This demonstrates that simulated groundwater contribution should be constrained by independent data to ensure results

  20. Neutron-activation analysis by standard addition and solvent extraction Determination of traces of antimony.

    PubMed

    Alian, A; Shabana, R; Sanad, W; Allam, B; Khalifa, K

    1968-02-01

    The application of neutron activation analysis by standard addition and solvent extraction to the determination of traces of antimony in aluminium and rocks is reported. Three simple extraction procedures, using isopropyl ether, hexone, and tributyl phosphate, are described for the selective separation of radioantimony from interfering radionuclides. Antimony concentration is measured by counting the activities of the (122)Sb and (124)Sb photopeaks at 0.564 and 0.603 MeV. PMID:18960289

  1. Observations Regarding Use of Advanced CFD Analysis, Sensitivity Analysis, and Design Codes in MDO

    NASA Technical Reports Server (NTRS)

    Newman, Perry A.; Hou, Gene J. W.; Taylor, Arthur C., III

    1996-01-01

    Observations regarding the use of advanced computational fluid dynamics (CFD) analysis, sensitivity analysis (SA), and design codes in gradient-based multidisciplinary design optimization (MDO) reflect our perception of the interactions required of CFD and our experience in recent aerodynamic design optimization studies using CFD. Sample results from these latter studies are summarized for conventional optimization (analysis - SA codes) and simultaneous analysis and design optimization (design code) using both Euler and Navier-Stokes flow approximations. The amount of computational resources required for aerodynamic design using CFD via analysis - SA codes is greater than that required for design codes. Thus, an MDO formulation that utilizes the more efficient design codes where possible is desired. However, in the aerovehicle MDO problem, the various disciplines that are involved have different design points in the flight envelope; therefore, CFD analysis - SA codes are required at the aerodynamic 'off design' points. The suggested MDO formulation is a hybrid multilevel optimization procedure that consists of both multipoint CFD analysis - SA codes and multipoint CFD design codes that perform suboptimizations.

  2. Implementation of terbium-sensitized luminescence in sequential-injection analysis for automatic analysis of orbifloxacin.

    PubMed

    Llorent-Martínez, E J; Ortega-Barrales, P; Molina-Díaz, A; Ruiz-Medina, A

    2008-12-01

    Orbifloxacin (ORBI) is a third-generation fluoroquinolone developed exclusively for use in veterinary medicine, mainly in companion animals. This antimicrobial agent has bactericidal activity against numerous gram-negative and gram-positive bacteria. A few chromatographic methods for its analysis have been described in the scientific literature. Here, coupling of sequential-injection analysis and solid-phase spectroscopy is described in order to develop, for the first time, a terbium-sensitized luminescent optosensor for analysis of ORBI. The cationic resin Sephadex-CM C-25 was used as solid support and measurements were made at 275/545 nm. The system had a linear dynamic range of 10-150 ng mL(-1), with a detection limit of 3.3 ng mL(-1) and an R.S.D. below 3% (n = 10). The analyte was satisfactorily determined in veterinary drugs and dog and horse urine. PMID:18958455

  3. Evaluation and recommendation of sensitivity analysis methods for application to Stochastic Human Exposure and Dose Simulation models.

    PubMed

    Mokhtari, Amirhossein; Christopher Frey, H; Zheng, Junyu

    2006-11-01

    Sensitivity analyses of exposure or risk models can help identify the most significant factors to aid in risk management or to prioritize additional research to reduce uncertainty in the estimates. However, sensitivity analysis is challenged by non-linearity, interactions between inputs, and multiple days or time scales. Selected sensitivity analysis methods are evaluated with respect to their applicability to human exposure models with such features using a testbed. The testbed is a simplified version of a US Environmental Protection Agency's Stochastic Human Exposure and Dose Simulation (SHEDS) model. The methods evaluated include the Pearson and Spearman correlation, sample and rank regression, analysis of variance, Fourier amplitude sensitivity test (FAST), and Sobol's method. The first five methods are known as "sampling-based" techniques, wheras the latter two methods are known as "variance-based" techniques. The main objective of the test cases was to identify the main and total contributions of individual inputs to the output variance. Sobol's method and FAST directly quantified these measures of sensitivity. Results show that sensitivity of an input typically changed when evaluated under different time scales (e.g., daily versus monthly). All methods provided similar insights regarding less important inputs; however, Sobol's method and FAST provided more robust insights with respect to sensitivity of important inputs compared to the sampling-based techniques. Thus, the sampling-based methods can be used in a screening step to identify unimportant inputs, followed by application of more computationally intensive refined methods to a smaller set of inputs. The implications of time variation in sensitivity results for risk management are briefly discussed. PMID:16519411

  4. Exploring the impact of forcing error characteristics on physically based snow simulations within a global sensitivity analysis framework

    NASA Astrophysics Data System (ADS)

    Raleigh, M. S.; Lundquist, J. D.; Clark, M. P.

    2015-07-01

    Physically based models provide insights into key hydrologic processes but are associated with uncertainties due to deficiencies in forcing data, model parameters, and model structure. Forcing uncertainty is enhanced in snow-affected catchments, where weather stations are scarce and prone to measurement errors, and meteorological variables exhibit high variability. Hence, there is limited understanding of how forcing error characteristics affect simulations of cold region hydrology and which error characteristics are most important. Here we employ global sensitivity analysis to explore how (1) different error types (i.e., bias, random errors), (2) different error probability distributions, and (3) different error magnitudes influence physically based simulations of four snow variables (snow water equivalent, ablation rates, snow disappearance, and sublimation). We use the Sobol' global sensitivity analysis, which is typically used for model parameters but adapted here for testing model sensitivity to coexisting errors in all forcings. We quantify the Utah Energy Balance model's sensitivity to forcing errors with 1 840 000 Monte Carlo simulations across four sites and five different scenarios. Model outputs were (1) consistently more sensitive to forcing biases than random errors, (2) generally less sensitive to forcing error distributions, and (3) critically sensitive to different forcings depending on the relative magnitude of errors. For typical error magnitudes found in areas with drifting snow, precipitation bias was the most important factor for snow water equivalent, ablation rates, and snow disappearance timing, but other forcings had a more dominant impact when precipitation uncertainty was due solely to gauge undercatch. Additionally, the relative importance of forcing errors depended on the model output of interest. Sensitivity analysis can reveal which forcing error characteristics matter most for hydrologic modeling.

  5. Design sensitivity analysis with Applicon IFAD using the adjoint variable method

    NASA Technical Reports Server (NTRS)

    Frederick, Marjorie C.; Choi, Kyung K.

    1984-01-01

    A numerical method is presented to implement structural design sensitivity analysis using the versatility and convenience of existing finite element structural analysis program and the theoretical foundation in structural design sensitivity analysis. Conventional design variables, such as thickness and cross-sectional areas, are considered. Structural performance functionals considered include compliance, displacement, and stress. It is shown that calculations can be carried out outside existing finite element codes, using postprocessing data only. That is, design sensitivity analysis software does not have to be imbedded in an existing finite element code. The finite element structural analysis program used in the implementation presented is IFAD. Feasibility of the method is shown through analysis of several problems, including built-up structures. Accurate design sensitivity results are obtained without the uncertainty of numerical accuracy associated with selection of a finite difference perturbation.

  6. PRACTICAL SENSITIVITY AND UNCERTAINTY ANALYSIS TECHNIQUES APPLIED TO AGRICULTURAL SYSTEMS MODELS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We present a practical evaluation framework for analysis of two complex, process-based agricultural system models, WEPP and RZWQM. The evaluation framework combines sensitivity analysis and the uncertainty analysis techniques of first order error analysis (FOA) and Monte Carlo simulation with Latin ...

  7. Assessing the Risk of Secondary Transfer Via Fingerprint Brush Contamination Using Enhanced Sensitivity DNA Analysis Methods.

    PubMed

    Bolivar, Paula-Andrea; Tracey, Martin; McCord, Bruce

    2016-01-01

    Experiments were performed to determine the extent of cross-contamination of DNA resulting from secondary transfer due to fingerprint brushes used on multiple items of evidence. Analysis of both standard and low copy number (LCN) STR was performed. Two different procedures were used to enhance sensitivity, post-PCR cleanup and increased cycle number. Under standard STR typing procedures, some additional alleles were produced that were not present in the controls or blanks; however, there was insufficient data to include the contaminant donor as a contributor. Inclusion of the contaminant donor did occur for one sample using post-PCR cleanup. Detection of the contaminant donor occurred for every replicate of the 31 cycle amplifications; however, using LCN interpretation recommendations for consensus profiles, only one sample would include the contaminant donor. Our results indicate that detection of secondary transfer of DNA can occur through fingerprint brush contamination and is enhanced using LCN-DNA methods. PMID:26300550

  8. Parameter identification and sensitivity analysis for a robotic manipulator arm

    NASA Technical Reports Server (NTRS)

    Brewer, D. W.; Gibson, J. S.

    1988-01-01

    The development of a nonlinear dynamic model for large oscillations of a robotic manipulator arm about a single joint is described. Optimization routines are formulated and implemented for the identification of electrical and physical parameters from dynamic data taken from an industrial robot arm. Special attention is given to difficulties caused by the large sensitivity of the model with respect to unknown parameters. Performance of the parameter identification algorithm is improved by choosing a control input that allows actuator emf to be included in an electro-mechanical model of the manipulator system.

  9. Automatic differentiation for design sensitivity analysis of structural systems using multiple processors

    NASA Technical Reports Server (NTRS)

    Nguyen, Duc T.; Storaasli, Olaf O.; Qin, Jiangning; Qamar, Ramzi

    1994-01-01

    An automatic differentiation tool (ADIFOR) is incorporated into a finite element based structural analysis program for shape and non-shape design sensitivity analysis of structural systems. The entire analysis and sensitivity procedures are parallelized and vectorized for high performance computation. Small scale examples to verify the accuracy of the proposed program and a medium scale example to demonstrate the parallel vector performance on multiple CRAY C90 processors are included.

  10. Sensitivity analysis as a general tool for model optimisation - examples for trajectory estimation

    NASA Astrophysics Data System (ADS)

    Schwieger, Volker

    2007-05-01

    This paper outlines the general characteristics of variance-based sensitivity analysis and their advantages with respect to other concepts of sensitivity analysis. The main benefit are qualitative and quantitative correct results independent of the model characteristics. The author focuses on kinematic positioning as required for car navigation, driver assistance systems or machine guidance. The paper compares two different Kalman filter approaches using variance analysis and variance-based sensitivity analysis. The approaches differ with respect to their measurement quantities (input), their state quantities (output), as well as their dynamic vehicle model. The sensitivity analysis shows that each model has its different advantages and input-output relations. Furthermore it is shown that the variance-based sensitivity analysis is well suited to detect the share of the influence of the input quantities on the output quantities, here the estimated positions. Even more important, changes in deterministic and stochastic models lead to obvious effects in the respective variances and sensitivity measures. This emphasises the possibility to optimise the filter models by use of the variance-based sensitivity analysis.

  11. Developing optical traps for ultra-sensitive analysis

    SciTech Connect

    Zhao, X.; Vieira, D.J.; Guckert, R. |; Crane, S.

    1998-09-01

    The authors describe the coupling of a magneto-optical trap to a mass separator for the ultra-sensitive detection of selected radioactive species. As a proof of principle test, they have demonstrated the trapping of {approximately} 6 million {sup 82} Rb (t{sub 1/2} = 75 s) atoms using an ion implantation and heated foil release method for introducing the sample into a trapping cell with minimal gas loading. Gamma-ray counting techniques were used to determine the efficiencies of each step in the process. By far the weakest step in the process is the efficiency of the optical trap itself (0.3%). Further improvements in the quality of the nonstick dryfilm coating on the inside of the trapping cell and the possible use of larger diameter laser beams are indicated. In the presence of a large background of scattered light, this initial work achieved a detection sensitivity of {approximately} 4,000 trapped atoms. Improved detection schemes using a pulsed trap and gated photon detection method are outlined. Application of this technology to the areas of environmental monitoring and nuclear proliferation are foreseen.

  12. Sensitivity analysis of vegetation-induced flow steering in channels

    NASA Astrophysics Data System (ADS)

    Bywater-Reyes, S.; Wilcox, A. C.; Lightbody, A.; Stella, J. C.

    2014-12-01

    Morphodynamic feedbacks result in alternating bars within channels, and the resulting convective accelerations dictate the cross-stream force balance of channels and in turn influence morphology. Pioneer woody riparian trees recruit on river bars and may steer flow and alter this force balance. This study uses two-dimensional hydraulic modeling to test the sensitivity of the flow field to riparian vegetation at the reach scale. We use two test systems with different width-to-depth ratios, substrate sizes, and vegetation structure: the gravel-bed Bitterroot River, MT and the sand-bed Santa Maria River, AZ. We model vegetation explicitly as a drag force by spatially specifying vegetation density, height, and drag coefficient, across varying hydraulic (e.g., discharge, eddy viscosity) conditions and compare velocity vectors between runs. We test variations in vegetation configurations, including the present-day configuration of vegetation in our field systems (extracted from LiDAR), removal of vegetation (e.g., from floods or management actions), and expansion of vegetation. Preliminary model runs suggest that the sensitivity of convective accelerations to vegetation reflects a balance between the extent and density of vegetation inundated and other sources of channel roughness. This research quantifies how vegetation alters hydraulics at the reach scale, a fundamental step to understanding vegetation-morphodynamic interactions.

  13. Some Advanced Concepts in Discrete Aerodynamic Sensitivity Analysis

    NASA Technical Reports Server (NTRS)

    Taylor, Arthur C., III; Green, Lawrence L.; Newman, Perry A.; Putko, Michele M.

    2003-01-01

    An efficient incremental iterative approach for differentiating advanced flow codes is successfully demonstrated on a two-dimensional inviscid model problem. The method employs the reverse-mode capability of the automatic differentiation software tool ADIFOR 3.0 and is proven to yield accurate first-order aerodynamic sensitivity derivatives. A substantial reduction in CPU time and computer memory is demonstrated in comparison with results from a straightforward, black-box reverse-mode applicaiton of ADIFOR 3.0 to the same flow code. An ADIFOR-assisted procedure for accurate second-rder aerodynamic sensitivity derivatives is successfully verified on an inviscid transonic lifting airfoil example problem. The method requires that first-order derivatives are calculated first using both the forward (direct) and reverse (adjoinct) procedures; then, a very efficient noniterative calculation of all second-order derivatives can be accomplished. Accurate second derivatives (i.e., the complete Hesian matrices) of lift, wave drag, and pitching-moment coefficients are calculated with respect to geometric shape, angle of attack, and freestream Mach number.

  14. Some Advanced Concepts in Discrete Aerodynamic Sensitivity Analysis

    NASA Technical Reports Server (NTRS)

    Taylor, Arthur C., III; Green, Lawrence L.; Newman, Perry A.; Putko, Michele M.

    2001-01-01

    An efficient incremental-iterative approach for differentiating advanced flow codes is successfully demonstrated on a 2D inviscid model problem. The method employs the reverse-mode capability of the automatic- differentiation software tool ADIFOR 3.0, and is proven to yield accurate first-order aerodynamic sensitivity derivatives. A substantial reduction in CPU time and computer memory is demonstrated in comparison with results from a straight-forward, black-box reverse- mode application of ADIFOR 3.0 to the same flow code. An ADIFOR-assisted procedure for accurate second-order aerodynamic sensitivity derivatives is successfully verified on an inviscid transonic lifting airfoil example problem. The method requires that first-order derivatives are calculated first using both the forward (direct) and reverse (adjoint) procedures; then, a very efficient non-iterative calculation of all second-order derivatives can be accomplished. Accurate second derivatives (i.e., the complete Hessian matrices) of lift, wave-drag, and pitching-moment coefficients are calculated with respect to geometric- shape, angle-of-attack, and freestream Mach number

  15. Multi-Dimensional, Discrete-Ordinates Based Cross Section Sensitivity and Uncertainty Analysis Code System.

    2008-05-22

    are the latest versions available from NEA-DB). o The memory and data management was updated as well as the language level (code was rewritten from Fortran-77 to Fortran-95). SUSD3D is coupled to several discrete‑ordinates codes via binary interface files. SUSD3D can use the flux moment files produced by discrete ordinates codes: ANISN, DORT, TORT, ONEDANT, TWODANT, and THREEDANT. In some of these codes minor modifications are required. Variable dimensions used in the TORT‑DORT system are supported. In 3D analysis the geometry and material composition is taken directly from the TORT produced VARSCL binary file, reducing in this way the user's input to SUSD3D. Multigroup cross‑section sets are read in the GENDF format of the NJOY/GROUPR code system, and the covariance data are expected in the COVFIL format of NJOY/ERRORR or the COVERX format of PUFF‑2. The ZZ‑VITAMIN‑J/COVA cross section covariance matrix library can be used as an alternative to the NJOY code system. The package includes the ANGELO code to produce the covariance data in the required energy structure in the COVFIL format. The following cross section processing modules to be added to the NJOY‑94 code system are included in the package: o ERR34: an extension of the ERRORR module of the NJOY code system for the File‑34 processing. It is used to prepare multigroup SAD cross sections covariance matrices. o GROUPSR: An additional code module for the preparation of partial cross sections for SAD sensitivity analysis. Updated version of the same code from SUSD, extended to the ENDF‑6 format. o SEADR: An additional code module to prepare group covariance matrices for SAD/SED uncertainty analysis.« less

  16. Quantitative and sensitive analysis of CN molecules using laser induced low pressure He plasma

    NASA Astrophysics Data System (ADS)

    Pardede, Marincan; Hedwig, Rinda; Abdulmadjid, Syahrun Nur; Lahna, Kurnia; Idris, Nasrullah; Jobiliong, Eric; Suyanto, Hery; Marpaung, Alion Mangasi; Suliyanti, Maria Margaretha; Ramli, Muliadi; Tjia, May On; Lie, Tjung Jie; Lie, Zener Sukra; Kurniawan, Davy Putra; Kurniawan, Koo Hendrik; Kagawa, Kiichiro

    2015-03-01

    We report the results of experimental study on CN 388.3 nm and C I 247.8 nm emission characteristics using 40 mJ laser irradiation with He and N2 ambient gases. The results obtained with N2 ambient gas show undesirable interference effect between the native CN emission and the emission of CN molecules arising from the recombination of native C ablated from the sample with the N dissociated from the ambient gas. This problem is overcome by the use of He ambient gas at low pressure of 2 kPa, which also offers the additional advantages of cleaner and stronger emission lines. The result of applying this favorable experimental condition to emission spectrochemical measurement of milk sample having various protein concentrations is shown to yield a close to linear calibration curve with near zero extrapolated intercept. Additionally, a low detection limit of 5 μg/g is found in this experiment, making it potentially applicable for quantitative and sensitive CN analysis. The visibility of laser induced breakdown spectroscopy with low pressure He gas is also demonstrated by the result of its application to spectrochemical analysis of fossil samples. Furthermore, with the use of CO2 ambient gas at 600 Pa mimicking the Mars atmosphere, this technique also shows promising applications to exploration in Mars.

  17. Quantitative and sensitive analysis of CN molecules using laser induced low pressure He plasma

    SciTech Connect

    Pardede, Marincan; Hedwig, Rinda; Abdulmadjid, Syahrun Nur; Lahna, Kurnia; Idris, Nasrullah; Ramli, Muliadi; Jobiliong, Eric; Suyanto, Hery; Marpaung, Alion Mangasi; Suliyanti, Maria Margaretha; Tjia, May On

    2015-03-21

    We report the results of experimental study on CN 388.3 nm and C I 247.8 nm emission characteristics using 40 mJ laser irradiation with He and N{sub 2} ambient gases. The results obtained with N{sub 2} ambient gas show undesirable interference effect between the native CN emission and the emission of CN molecules arising from the recombination of native C ablated from the sample with the N dissociated from the ambient gas. This problem is overcome by the use of He ambient gas at low pressure of 2 kPa, which also offers the additional advantages of cleaner and stronger emission lines. The result of applying this favorable experimental condition to emission spectrochemical measurement of milk sample having various protein concentrations is shown to yield a close to linear calibration curve with near zero extrapolated intercept. Additionally, a low detection limit of 5 μg/g is found in this experiment, making it potentially applicable for quantitative and sensitive CN analysis. The visibility of laser induced breakdown spectroscopy with low pressure He gas is also demonstrated by the result of its application to spectrochemical analysis of fossil samples. Furthermore, with the use of CO{sub 2} ambient gas at 600 Pa mimicking the Mars atmosphere, this technique also shows promising applications to exploration in Mars.

  18. Sensitivity analysis of DOA estimation algorithms to sensor errors

    NASA Astrophysics Data System (ADS)

    Li, Fu; Vaccaro, Richard J.

    1992-07-01

    A unified statistical performance analysis using subspace perturbation expansions is applied to subspace-based algorithms for direction-of-arrival (DOA) estimation in the presence of sensor errors. In particular, the multiple signal classification (MUSIC), min-norm, state-space realization (TAM and DDA) and estimation of signal parameters via rotational invariance techniques (ESPRIT) algorithms are analyzed. This analysis assumes that only a finite amount of data is available. An analytical expression for the mean-squared error of the DOA estimates is developed for theoretical comparison in a simple and self-contained fashion. The tractable formulas provide insight into the algorithms. Simulation results verify the analysis.

  19. Variational Methods in Design Optimization and Sensitivity Analysis for Two-Dimensional Euler Equations

    NASA Technical Reports Server (NTRS)

    Ibrahim, A. H.; Tiwari, S. N.; Smith, R. E.

    1997-01-01

    Variational methods (VM) sensitivity analysis employed to derive the costate (adjoint) equations, the transversality conditions, and the functional sensitivity derivatives. In the derivation of the sensitivity equations, the variational methods use the generalized calculus of variations, in which the variable boundary is considered as the design function. The converged solution of the state equations together with the converged solution of the costate equations are integrated along the domain boundary to uniquely determine the functional sensitivity derivatives with respect to the design function. The application of the variational methods to aerodynamic shape optimization problems is demonstrated for internal flow problems at supersonic Mach number range. The study shows, that while maintaining the accuracy of the functional sensitivity derivatives within the reasonable range for engineering prediction purposes, the variational methods show a substantial gain in computational efficiency, i.e., computer time and memory, when compared with the finite difference sensitivity analysis.

  20. ANALYSIS OF DISTRIBUTION FEEDER LOSSES DUE TO ADDITION OF DISTRIBUTED PHOTOVOLTAIC GENERATORS

    SciTech Connect

    Tuffner, Francis K.; Singh, Ruchi

    2011-08-09

    Distributed generators (DG) are small scale power supplying sources owned by customers or utilities and scattered throughout the power system distribution network. Distributed generation can be both renewable and non-renewable. Addition of distributed generation is primarily to increase feeder capacity and to provide peak load reduction. However, this addition comes with several impacts on the distribution feeder. Several studies have shown that addition of DG leads to reduction of feeder loss. However, most of these studies have considered lumped load and distributed load models to analyze the effects on system losses, where the dynamic variation of load due to seasonal changes is ignored. It is very important for utilities to minimize the losses under all scenarios to decrease revenue losses, promote efficient asset utilization, and therefore, increase feeder capacity. This paper will investigate an IEEE 13-node feeder populated with photovoltaic generators on detailed residential houses with water heater, Heating Ventilation and Air conditioning (HVAC) units, lights, and other plug and convenience loads. An analysis of losses for different power system components, such as transformers, underground and overhead lines, and triplex lines, will be performed. The analysis will utilize different seasons and different solar penetration levels (15%, 30%).

  1. Analysis of redox additive-based overcharge protection for rechargeable lithium batteries

    NASA Technical Reports Server (NTRS)

    Narayanan, S. R.; Surampudi, S.; Attia, A. I.; Bankston, C. P.

    1991-01-01

    The overcharge condition in secondary lithium batteries employing redox additives for overcharge protection, has been theoretically analyzed in terms of a finite linear diffusion model. The analysis leads to expressions relating the steady-state overcharge current density and cell voltage to the concentration, diffusion coefficient, standard reduction potential of the redox couple, and interelectrode distance. The model permits the estimation of the maximum permissible overcharge rate for any chosen set of system conditions. Digital simulation of the overcharge experiment leads to numerical representation of the potential transients, and estimate of the influence of diffusion coefficient and interelectrode distance on the transient attainment of the steady state during overcharge. The model has been experimentally verified using 1,1-prime-dimethyl ferrocene as a redox additive. The analysis of the experimental results in terms of the theory allows the calculation of the diffusion coefficient and the formal potential of the redox couple. The model and the theoretical results may be exploited in the design and optimization of overcharge protection by the redox additive approach.

  2. Preconditioned domain decomposition scheme for three-dimensional aerodynamic sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Eleshaky, Mohammed E.; Baysal, Oktay

    1993-01-01

    A preconditioned domain decomposition scheme is introduced for the solution of the 3D aerodynamic sensitivity equation. This scheme uses the iterative GMRES procedure to solve the effective sensitivity equation of the boundary-interface cells in the sensitivity analysis domain-decomposition scheme. Excluding the dense matrices and the effect of cross terms between boundary-interfaces is found to produce an efficient preconditioning matrix.

  3. Dye-Sensitized and Localized Surface Plasmon Resonance Enhanced Visible-Light Photoelectrochemical Biosensors for Highly Sensitive Analysis of Protein Kinase Activity.

    PubMed

    Yan, Zhiyong; Wang, Zonghua; Miao, Zhuang; Liu, Yang

    2016-01-01

    A novel visible-light photoelectrochemical (PEC) biosensor based on localized surface plasmon resonance (LSPR) enhancement and dye sensitization was fabricated for highly sensitive analysis of protein kinase activity with ultralow background. In this strategy, DNA conjugated gold nanoparticles (DNA@AuNPs) were assembled on the phosphorylated kemptide modified TiO2/ITO electrode through the chelation between Zr(4+) ions and phosphate groups, then followed by the intercalation of [Ru(bpy)3](2+) into DNA grooves. The adsorbed [Ru(bpy)3](2+) can harvest visible light to produce excited electrons that inject into the TiO2 conduction band to form photocurrent under visible light irradiation. In addition, the photocurrent efficiency was further improved by the LSPR of AuNPs under the irradiation of visible light. Moreover, because of the excellent conductivity and large surface area of AuNPs that facilitate electron-transfer and accommodate large number of [Ru(bpy)3](2+), the photocurrent was significantly amplified, affording an extremely sensitive PEC analysis of kinase activity with ultralow background signals. The detection limit of as-proposed PEC biosensor was 0.005 U mL(-1) (S/N = 3). The biosensor also showed excellent performances for quantitative kinase inhibitor screening and PKA activities detection in MCF-7 cell lysates under forskolin and ellagic acid stimulation. The developed dye-sensitization and LSPR enhancement visible-light PEC biosensor shows great potential in protein kinases-related clinical diagnosis and drug discovery. PMID:26648204

  4. Inference of Climate Sensitivity from Analysis of Earth's Energy Budget

    NASA Astrophysics Data System (ADS)

    Forster, Piers M.

    2016-06-01

    Recent attempts to diagnose equilibrium climate sensitivity (ECS) from changes in Earth's energy budget point toward values at the low end of the Intergovernmental Panel on Climate Change Fifth Assessment Report (AR5)'s likely range (1.5–4.5 K). These studies employ observations but still require an element of modeling to infer ECS. Their diagnosed effective ECS over the historical period of around 2 K holds up to scrutiny, but there is tentative evidence that this underestimates the true ECS from a doubling of carbon dioxide. Different choices of energy imbalance data explain most of the difference between published best estimates, and effective radiative forcing dominates the overall uncertainty. For decadal analyses the largest source of uncertainty comes from a poor understanding of the relationship between ECS and decadal feedback. Considerable progress could be made by diagnosing effective radiative forcing in models.

  5. Uncertainty analysis and global sensitivity analysis of techno-economic assessments for biodiesel production.

    PubMed

    Tang, Zhang-Chun; Zhenzhou, Lu; Zhiwen, Liu; Ningcong, Xiao

    2015-01-01

    There are various uncertain parameters in the techno-economic assessments (TEAs) of biodiesel production, including capital cost, interest rate, feedstock price, maintenance rate, biodiesel conversion efficiency, glycerol price and operating cost. However, fewer studies focus on the influence of these parameters on TEAs. This paper investigated the effects of these parameters on the life cycle cost (LCC) and the unit cost (UC) in the TEAs of biodiesel production. The results show that LCC and UC exhibit variations when involving uncertain parameters. Based on the uncertainty analysis, three global sensitivity analysis (GSA) methods are utilized to quantify the contribution of an individual uncertain parameter to LCC and UC. The GSA results reveal that the feedstock price and the interest rate produce considerable effects on the TEAs. These results can provide a useful guide for entrepreneurs when they plan plants. PMID:25459861

  6. Comprehensive mechanisms for combustion chemistry: Experiment, modeling, and sensitivity analysis

    SciTech Connect

    Dryer, F.L.; Yetter, R.A.

    1993-12-01

    This research program is an integrated experimental/numerical effort to study pyrolysis and oxidation reactions and mechanisms for small-molecule hydrocarbon structures under conditions representative of combustion environments. The experimental aspects of the work are conducted in large diameter flow reactors, at pressures from one to twenty atmospheres, temperatures from 550 K to 1200 K, and with observed reaction times from 10{sup {minus}2} to 5 seconds. Gas sampling of stable reactant, intermediate, and product species concentrations provides not only substantial definition of the phenomenology of reaction mechanisms, but a significantly constrained set of kinetic information with negligible diffusive coupling. Analytical techniques used for detecting hydrocarbons and carbon oxides include gas chromatography (GC), and gas infrared (NDIR) and FTIR methods are utilized for continuous on-line sample detection of light absorption measurements of OH have also been performed in an atmospheric pressure flow reactor (APFR), and a variable pressure flow (VPFR) reactor is presently being instrumented to perform optical measurements of radicals and highly reactive molecular intermediates. The numerical aspects of the work utilize zero and one-dimensional pre-mixed, detailed kinetic studies, including path, elemental gradient sensitivity, and feature sensitivity analyses. The program emphasizes the use of hierarchical mechanistic construction to understand and develop detailed kinetic mechanisms. Numerical studies are utilized for guiding experimental parameter selections, for interpreting observations, for extending the predictive range of mechanism constructs, and to study the effects of diffusive transport coupling on reaction behavior in flames. Modeling using well defined and validated mechanisms for the CO/H{sub 2}/oxidant systems.

  7. Sensitivity Analysis and Stochastic Simulations of Non-equilibrium Plasma Flow

    SciTech Connect

    Lin, Guang; Karniadakis, George E.

    2009-11-05

    We study parametric uncertainties involved in plasma flows and apply stochastic sensitivity analysis to rank the importance of all inputs to guide large-scale stochastic simulations. Specifically, we employ different gradient-based sensitivity methods, namely Morris, multi-element probabilistic collocation method (ME-PCM) on sparse grids, Quasi-Monte Carlo, and Monte Carlo methods. These approaches go beyond the standard ``One-At-a-Time" sensitivity analysis and provide a measure of the nonlinear interaction effects for the uncertain inputs. The objective is to perform systematic stochastic simulations of plasma flows treating only as {\\em stochastic processes} the inputs with the highest sensitivity index, hence reducing substantially the computational cost. Two plasma flow examples are presented to demonstrate the capability and efficiency of the stochastic sensitivity analysis. The first one is a two-fluid model in a shock tube while the second one is a one-fluid/two-temperature model in flow past a cylinder.

  8. Reduction and Uncertainty Analysis of Chemical Mechanisms Based on Local and Global Sensitivities

    NASA Astrophysics Data System (ADS)

    Esposito, Gaetano

    Numerical simulations of critical reacting flow phenomena in hypersonic propulsion devices require accurate representation of finite-rate chemical kinetics. The chemical kinetic models available for hydrocarbon fuel combustion are rather large, involving hundreds of species and thousands of reactions. As a consequence, they cannot be used in multi-dimensional computational fluid dynamic calculations in the foreseeable future due to the prohibitive computational cost. In addition to the computational difficulties, it is also known that some fundamental chemical kinetic parameters of detailed models have significant level of uncertainty due to limited experimental data available and to poor understanding of interactions among kinetic parameters. In the present investigation, local and global sensitivity analysis techniques are employed to develop a systematic approach of reducing and analyzing detailed chemical kinetic models. Unlike previous studies in which skeletal model reduction was based on the separate analysis of simple cases, in this work a novel strategy based on Principal Component Analysis of local sensitivity values is presented. This new approach is capable of simultaneously taking into account all the relevant canonical combustion configurations over different composition, temperature and pressure conditions. Moreover, the procedure developed in this work represents the first documented inclusion of non-premixed extinction phenomena, which is of great relevance in hypersonic combustors, in an automated reduction algorithm. The application of the skeletal reduction to a detailed kinetic model consisting of 111 species in 784 reactions is demonstrated. The resulting reduced skeletal model of 37--38 species showed that the global ignition/propagation/extinction phenomena of ethylene-air mixtures can be predicted within an accuracy of 2% of the full detailed model. The problems of both understanding non-linear interactions between kinetic parameters and

  9. Intra-Articular Corticosteroids in Addition to Exercise for Reducing Pain Sensitivity in Knee Osteoarthritis: Exploratory Outcome from a Randomized Controlled Trial

    PubMed Central

    Soriano-Maldonado, Alberto; Klokker, Louise; Bartholdy, Cecilie; Bandak, Elisabeth; Ellegaard, Karen; Bliddal, Henning; Henriksen, Marius

    2016-01-01

    Objective To assess the effects of one intra-articular corticosteroid injection two weeks prior to an exercise-based intervention program for reducing pain sensitivity in patients with knee osteoarthritis (OA). Design Randomized, masked, parallel, placebo-controlled trial involving 100 participants with clinical and radiographic knee OA that were randomized to one intra-articular injection on the knee with either 1 ml of 40 mg/ml methylprednisolone (corticosteroid) dissolved in 4 ml lidocaine (10 mg/ml) or 1 ml isotonic saline (placebo) mixed with 4 ml lidocaine (10 mg/ml). Two weeks after the injections all participants undertook a 12-week supervised exercise program. Main outcomes were changes from baseline in pressure-pain sensitivity (pressure-pain threshold [PPT] and temporal summation [TS]) assessed using cuff pressure algometry on the calf. These were exploratory outcomes from a randomized controlled trial. Results A total of 100 patients were randomized to receive either corticosteroid (n = 50) or placebo (n = 50); 45 and 44, respectively, completed the trial. Four participants had missing values for PPT and one for TS at baseline; thus modified intention-to-treat populations were analyzed. The mean group difference in changes from baseline at week 14 was 0.6 kPa (95% CI: -1.7 to 2.8; P = 0.626) for PPT and 384 mm×sec (95% CI: -2980 to 3750; P = 0.821) for TS. Conclusions These results suggest that adding intra-articular corticosteroid injection 2 weeks prior to an exercise program does not provide additional benefits compared to placebo in reducing pain sensitivity in patients with knee OA. Trial Registration EU clinical trials (EudraCT): 2012-002607-18 PMID:26871954

  10. Results of an integrated structure-control law design sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Gilbert, Michael G.

    1988-01-01

    Next generation air and space vehicle designs are driven by increased performance requirements, demanding a high level of design integration between traditionally separate design disciplines. Interdisciplinary analysis capabilities have been developed, for aeroservoelastic aircraft and large flexible spacecraft control for instance, but the requisite integrated design methods are only beginning to be developed. One integrated design method which has received attention is based on hierarchal problem decompositions, optimization, and design sensitivity analyses. This paper highlights a design sensitivity analysis method for Linear Quadratic Cost, Gaussian (LQG) optimal control laws, which predicts change in the optimal control law due to changes in fixed problem parameters using analytical sensitivity equations. Numerical results of a design sensitivity analysis for a realistic aeroservoelastic aircraft example are presented. In this example, the sensitivity of the optimally controlled aircraft's response to various problem formulation and physical aircraft parameters is determined. These results are used to predict the aircraft's new optimally controlled response if the parameter was to have some other nominal value during the control law design process. The sensitivity results are validated by recomputing the optimal control law for discrete variations in parameters, computing the new actual aircraft response, and comparing with the predicted response. These results show an improvement in sensitivity accuracy for integrated design purposes over methods which do not include changess in the optimal control law. Use of the analytical LQG sensitivity expressions is also shown to be more efficient that finite difference methods for the computation of the equivalent sensitivity information.

  11. Analysis of error-prone survival data under additive hazards models: measurement error effects and adjustments.

    PubMed

    Yan, Ying; Yi, Grace Y

    2016-07-01

    Covariate measurement error occurs commonly in survival analysis. Under the proportional hazards model, measurement error effects have been well studied, and various inference methods have been developed to correct for error effects under such a model. In contrast, error-contaminated survival data under the additive hazards model have received relatively less attention. In this paper, we investigate this problem by exploring measurement error effects on parameter estimation and the change of the hazard function. New insights of measurement error effects are revealed, as opposed to well-documented results for the Cox proportional hazards model. We propose a class of bias correction estimators that embraces certain existing estimators as special cases. In addition, we exploit the regression calibration method to reduce measurement error effects. Theoretical results for the developed methods are established, and numerical assessments are conducted to illustrate the finite sample performance of our methods. PMID:26328545

  12. In-line image analysis on the effects of additives in batch cooling crystallization

    NASA Astrophysics Data System (ADS)

    Qu, Haiyan; Louhi-Kultanen, Marjatta; Kallas, Juha

    2006-03-01

    The effects of two potassium salt additives, ethylene diamine tetra acetic acid dipotassium salt (EDTA) and potassium pyrophosphate (KPY), on the batch cooling crystallization of potassium dihydrogen phosphate (KDP) were investigated. The crystal growth rates of certain crystal faces were determined from in-line images taken with a MTS particle image analysis (PIA) video microscope. An in-line image processing method was developed to characterize the size and shape of the crystals. The nucleation kinetics was studied by measurement of the metastable zone width and induction time. A significant promotion effect on both nucleation and growth of KDP was observed when EDTA was used as an additive. KPY, however, exhibited strong inhibiting impacts. The mechanism underlying the EDTA promotion effect on crystal growth was further studied with the 2-dimension nucleation model. It is shown that the presence of EDTA increased the density of adsorbed molecules of the crystallizing solute on the surface of the crystal.

  13. Modelling suspended-sediment propagation and related heavy metal contamination in floodplains: a parameter sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Hostache, R.; Hissler, C.; Matgen, P.; Guignard, C.; Bates, P.

    2014-09-01

    Fine sediments represent an important vector of pollutant diffusion in rivers. When deposited in floodplains and riverbeds, they can be responsible for soil pollution. In this context, this paper proposes a modelling exercise aimed at predicting transport and diffusion of fine sediments and dissolved pollutants. The model is based upon the Telemac hydro-informatic system (dynamical coupling Telemac-2D-Sysiphe). As empirical and semiempirical parameters need to be calibrated for such a modelling exercise, a sensitivity analysis is proposed. An innovative point in this study is the assessment of the usefulness of dissolved trace metal contamination information for model calibration. Moreover, for supporting the modelling exercise, an extensive database was set up during two flood events. It includes water surface elevation records, discharge measurements and geochemistry data such as time series of dissolved/particulate contaminants and suspended-sediment concentrations. The most sensitive parameters were found to be the hydraulic friction coefficients and the sediment particle settling velocity in water. It was also found that model calibration did not benefit from dissolved trace metal contamination information. Using the two monitored hydrological events as calibration and validation, it was found that the model is able to satisfyingly predict suspended sediment and dissolve pollutant transport in the river channel. In addition, a qualitative comparison between simulated sediment deposition in the floodplain and a soil contamination map shows that the preferential zones for deposition identified by the model are realistic.

  14. Ultra-high resolution, polarization sensitive transversal optical coherence tomography for structural analysis and strain mapping

    NASA Astrophysics Data System (ADS)

    Wiesauer, Karin; Pircher, Michael; Goetzinger, Erich; Hitzenberger, Christoph K.; Engelke, Rainer; Ahrens, Gisela; Pfeiffer, Karl; Ostrzinski, Ute; Gruetzner, Gabi; Oster, Reinhold; Stifter, David

    2006-02-01

    Optical coherence tomography (OCT) is a contactless and non-invasive technique nearly exclusively applied for bio-medical imaging of tissues. Besides the internal structure, additionally strains within the sample can be mapped when OCT is performed in a polarization sensitive (PS) way. In this work, we demonstrate the benefits of PS-OCT imaging for non-biological applications. We have developed the OCT technique beyond the state-of-the-art: based on transversal ultra-high resolution (UHR-)OCT, where an axial resolution below 2 μm within materials is obtained using a femtosecond laser as light source, we have modified the setup for polarization sensitive measurements (transversal UHR-PS-OCT). We perform structural analysis and strain mapping for different types of samples: for a highly strained elastomer specimen we demonstrate the necessity of UHR-imaging. Furthermore, we investigate epoxy waveguide structures, photoresist moulds for the fabrication of micro-electromechanical parts (MEMS), and the glass-fibre composite outer shell of helicopter rotor blades where cracks are present. For these examples, transversal scanning UHR-PS-OCT is shown to provide important information about the structural properties and the strain distribution within the samples.

  15. Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos

    PubMed Central

    McCarthy, Gregory D.; Drewell, Robert A.

    2015-01-01

    It is well known that gene regulation is a tightly controlled process in early organismal development. However, the roles of key processes involved in this regulation, such as transcription and translation, are less well understood, and mathematical modeling approaches in this field are still in their infancy. In recent studies, biologists have taken precise measurements of protein and mRNA abundance to determine the relative contributions of key factors involved in regulating protein levels in mammalian cells. We now approach this question from a mathematical modeling perspective. In this study, we use a simple dynamic mathematical model that incorporates terms representing transcription, translation, mRNA and protein decay, and diffusion in an early Drosophila embryo. We perform global sensitivity analyses on this model using various different initial conditions and spatial and temporal outputs. Our results indicate that transcription and translation are often the key parameters to determine protein abundance. This observation is in close agreement with the experimental results from mammalian cells for various initial conditions at particular time points, suggesting that a simple dynamic model can capture the qualitative behavior of a gene. Additionally, we find that parameter sensitivites are temporally dynamic, illustrating the importance of conducting a thorough global sensitivity analysis across multiple time points when analyzing mathematical models of gene regulation. PMID:26157608

  16. Cross Section Sensitivity and Uncertainty Analysis Including Secondary Neutron Energy and Angular Distributions.

    1991-03-12

    Version 00 SUSD calculates sensitivity coefficients for one- and two-dimensional transport problems. Variance and standard deviation of detector responses or design parameters can be obtained using cross-section covariance matrices. In neutron transport problems, this code can perform sensitivity-uncertainty analysis for secondary angular distribution (SAD) or secondary energy distribution (SED).

  17. Analysis of Sensitivity and Uncertainty in an Individual-Based Model of a Threatened Wildlife Species

    EPA Science Inventory

    We present a multi-faceted sensitivity analysis of a spatially explicit, individual-based model (IBM) (HexSim) of a threatened species, the Northern Spotted Owl (Strix occidentalis caurina) on a national forest in Washington, USA. Few sensitivity analyses have been conducted on ...

  18. Effects of zinc additions on the stress corrosion crack growth rate of sensitized stainless steel, Alloy 600 and Alloy 182 weld metal in 288 C water

    SciTech Connect

    Andresen, P.L.; Angeliu, T.M.

    1995-09-01

    ZnO additions to boiling water reactor (BWR) water have been the focus of recent interest, primarily because of their beneficial influence in reducing buildup of radioactive species such as Co{sup 60} in the oxide film of structural components, e.g., stainless steel piping. The effect of ZnO additions on stress corrosion crack growth rates were studied using 1T CT fracture mechanics specimens of sensitized type 304 stainless steel, sensitized Alloy 600, and Alloy 182 weld metal exposed to {approx}288 C water containing various levels of dissolved oxygen and impurities. Zn levels of 5 to 100 ppb Zn{sup 2+} were evaluated and found to reduce crack growth rates for all materials and in all water chemistries. Many Zn tests involved long term exposure and were performed at somewhat reduced corrosion potential (e.g., from {approx}+200 to 0 {minus}+50 mV{sub she}); variations in corrosion potential from +200, to +50, to {minus}50 mV{sub she} clearly had an important effect. The benefit of Zn appeared to be most pronounced when the growth rate was decreased (e.g., by corrosion potential). This was consistent with the findings of mechanistic studies, which showed that Zn decreased the repassivation response at times >10{sup 4} s, which is associated with low crack tip strain rates, i.e., low growth rates. Reduced corrosion potentials are also expected to directly effect Zn, since high (crack mouth) corrosion potentials inhibit the transport of Zn{sup 2+} into the crack. Zn also increased the fracture strain of the oxide on stainless steel, and may also reduce crack growth rates by increasing the pH in the crack. Similar benefits are expected for other structural materials, such as nonsensitized or irradiated stainless steel, carbon steel, low alloy steel, and other nickel alloys.

  19. Neutron activation analysis by standard addition and solvent extraction: Determination of impurities in aluminium.

    PubMed

    Alian, A; Haggag, A

    1967-09-01

    A separation scheme based on selective extraction in conjunction with the standard addition technique has been developed for the determination of impurities in aluminium by neutron activation. Preliminary investigations have been carried out on the extractability of Sc, Co, Hf, Fe, Sn, Cd, Zn, Ag, Cr, Ce, Cs and Rb by TDA and TBP from acidic media. The best conditions are predicted for the separation of these elements into fractions suitable for analysis by gamma-ray spectrometry. Recovery values of approximately 90% were obtained for all the elements. PMID:18960206

  20. Addition of three-dimensional isoparametric elements to NASA structural analysis program (NASTRAN)

    NASA Technical Reports Server (NTRS)

    Field, E. I.; Johnson, S. E.

    1973-01-01

    Implementation is made of the three-dimensional family of linear, quadratic and cubic isoparametric solid elements into the NASA Structural Analysis program, NASTRAN. This work included program development, installation, testing, and documentation. The addition of these elements to NASTRAN provides a significant increase in modeling capability particularly for structures requiring specification of temperatures, material properties, displacements, and stresses which vary throughout each individual element. Complete program documentation is presented in the form of new sections and updates for direct insertion to the three NASTRAN manuals. The results of demonstration test problems are summarized. Excellent results are obtained with the isoparametric elements for static, normal mode, and buckling analyses.

  1. Methodology for sensitivity analysis, approximate analysis, and design optimization in CFD for multidisciplinary applications

    NASA Technical Reports Server (NTRS)

    Taylor, Arthur C., III; Hou, Gene W.

    1994-01-01

    The straightforward automatic-differentiation and the hand-differentiated incremental iterative methods are interwoven to produce a hybrid scheme that captures some of the strengths of each strategy. With this compromise, discrete aerodynamic sensitivity derivatives are calculated with the efficient incremental iterative solution algorithm of the original flow code. Moreover, the principal advantage of automatic differentiation is retained (i.e., all complicated source code for the derivative calculations is constructed quickly with accuracy). The basic equations for second-order sensitivity derivatives are presented; four methods are compared. Each scheme requires that large systems are solved first for the first-order derivatives and, in all but one method, for the first-order adjoint variables. Of these latter three schemes, two require no solutions of large systems thereafter. For the other two for which additional systems are solved, the equations and solution procedures are analogous to those for the first order derivatives. From a practical viewpoint, implementation of the second-order methods is feasible only with software tools such as automatic differentiation, because of the extreme complexity and large number of terms. First- and second-order sensitivities are calculated accurately for two airfoil problems, including a turbulent flow example; both geometric-shape and flow-condition design variables are considered. Several methods are tested; results are compared on the basis of accuracy, computational time, and computer memory. For first-order derivatives, the hybrid incremental iterative scheme obtained with automatic differentiation is competitive with the best hand-differentiated method; for six independent variables, it is at least two to four times faster than central finite differences and requires only 60 percent more memory than the original code; the performance is expected to improve further in the future.

  2. Re-analysis of survival data of cancer patients utilizing additive homeopathy.

    PubMed

    Gleiss, Andreas; Frass, Michael; Gaertner, Katharina

    2016-08-01

    In this short communication we present a re-analysis of homeopathic patient data in comparison to control patient data from the same Outpatient´s Unit "Homeopathy in malignant diseases" of the Medical University of Vienna. In this analysis we took account of a probable immortal time bias. For patients suffering from advanced stages of cancer and surviving the first 6 or 12 months after diagnosis, respectively, the results show that utilizing homeopathy gives a statistically significant (p<0.001) advantage over control patients regarding survival time. In conclusion, bearing in mind all limitations, the results of this retrospective study suggest that patients with advanced stages of cancer might benefit from additional homeopathic treatment until a survival time of up to 12 months after diagnosis. PMID:27515878

  3. Towards a controlled sensitivity analysis of model development decisions

    NASA Astrophysics Data System (ADS)

    Clark, Martyn; Nijssen, Bart

    2016-04-01

    The current generation of hydrologic models have followed a myriad of different development paths, making it difficult for the community to test underlying hypotheses and identify a clear path to model improvement. Model comparison studies have been undertaken to explore model differences, but these studies have not been able to meaningfully attribute inter-model differences in predictive ability to individual model components because there are often too many structural and implementation differences among the models considered. As a consequence, model comparison studies to date have provided limited insight into the causes of differences in model behavior, and model development has often relied on the inspiration and experience of individual modelers rather than a systematic analysis of model shortcomings. This presentation will discuss a unified approach to process-based hydrologic modeling to enable controlled and systematic analysis of multiple model representations (hypotheses) of hydrologic processes and scaling behavior. Our approach, which we term the Structure for Unifying Multiple Modeling Alternatives (SUMMA), formulates a general set of conservation equations, providing the flexibility to experiment with different spatial representations, different flux parameterizations, different model parameter values, and different time stepping schemes. We will discuss the use of SUMMA to systematically analyze different model development decisions, focusing on both analysis of simulations for intensively instrumented research watersheds as well as simulations across a global dataset of FLUXNET sites. The intent of the presentation is to demonstrate how the systematic analysis of model shortcomings can help identify model weaknesses and inform future model development priorities.

  4. Sensitivity Analysis of Mixed Models for Incomplete Longitudinal Data

    ERIC Educational Resources Information Center

    Xu, Shu; Blozis, Shelley A.

    2011-01-01

    Mixed models are used for the analysis of data measured over time to study population-level change and individual differences in change characteristics. Linear and nonlinear functions may be used to describe a longitudinal response, individuals need not be observed at the same time points, and missing data, assumed to be missing at random (MAR),…

  5. The application of Global Sensitivity Analysis to quantify the dominant input factors for hydraulic model simulations

    NASA Astrophysics Data System (ADS)

    Savage, James; Pianosi, Francesca; Bates, Paul; Freer, Jim; Wagener, Thorsten

    2015-04-01

    Predicting flood inundation extents using hydraulic models is subject to a number of critical uncertainties. For a specific event, these uncertainties are known to have a large influence on model outputs and any subsequent analyses made by risk managers. Hydraulic modellers often approach such problems by applying uncertainty analysis techniques such as the Generalised Likelihood Uncertainty Estimation (GLUE) methodology. However, these methods do not allow one to attribute which source of uncertainty has the most influence on the various model outputs that inform flood risk decision making. Another issue facing modellers is the amount of computational resource that is available to spend on modelling flood inundations that are 'fit for purpose' to the modelling objectives. Therefore a balance needs to be struck between computation time, realism and spatial resolution, and effectively characterising the uncertainty spread of predictions (for example from boundary conditions and model parameterisations). However, it is not fully understood how much of an impact each factor has on model performance, for example how much influence changing the spatial resolution of a model has on inundation predictions in comparison to other uncertainties inherent in the modelling process. Furthermore, when resampling fine scale topographic data in the form of a Digital Elevation Model (DEM) to coarser resolutions, there are a number of possible coarser DEMs that can be produced. Deciding which DEM is then chosen to represent the surface elevations in the model could also influence model performance. In this study we model a flood event using the hydraulic model LISFLOOD-FP and apply Sobol' Sensitivity Analysis to estimate which input factor, among the uncertainty in model boundary conditions, uncertain model parameters, the spatial resolution of the DEM and the choice of resampled DEM, have the most influence on a range of model outputs. These outputs include whole domain maximum

  6. Design tradeoff studies and sensitivity analysis, appendix B

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Further work was performed on the Near Term Hybrid Passenger Vehicle Development Program. Fuel economy on the order of 2 to 3 times that of a conventional vehicle, with a comparable life cycle cost, is possible. The two most significant factors in keeping the life cycle cost down are the retail price increment and the ratio of battery replacement cost to battery life. Both factors can be reduced by reducing the power rating of the electric drive portion of the system relative to the system power requirements. The type of battery most suitable for the hybrid, from the point of view of minimizing life cycle cost, is nickel-iron. The hybrid is much less sensitive than a conventional vehicle is, in terms of the reduction in total fuel consumption and resultant decreases in operating expense, to reductions in vehicle weight, tire rolling resistance, etc., and to propulsion system and drivetrain improvements designed to improve the brake specific fuel consumption of the engine under low road load conditions. It is concluded that modifications to package the propulsion system and battery pack can be easily accommodated within the confines of a modified carryover body such as the Ford Ltd.

  7. Comparative sensitivity analysis of transmission loss in beaked whale environments

    NASA Astrophysics Data System (ADS)

    Wezensky, Eryn M.; Miller, James H.; Tyce, Robert C.

    2001-05-01

    Scientific literature states that anthropogenic sound, such as mid-frequency sonar, may cause a behavioral response in marine mammals. The degree of response is highly variable and dependent upon many factors, including how sound transmission is influenced by environmental features. The physical parameters of the ocean medium, such as sound speed profile and bathymetry, are important controls of underwater acoustic propagation. Determining the acoustic propagation loss of the ocean environment is an application used to identify and correlate influential environmental factors. This study investigates the sensitivity of acoustic propagation loss based on specific physical characteristics found in five different sites representing beaked whale environments. These sites were chosen with regards to existing data on beaked whale distribution, historical mass stranding records, and presence of mid-frequency sonar activity. A range-independent, ray-tracing acoustic propagation model was used to generate a two-dimensional sound field over a range of 30 km. From the results of this experiment, the acoustic importance of bathymetry and sound speed profile of the five beaked whale environments were identified. Preliminary results from the experimental study will be presented.

  8. Sensitivity Analysis for Atmospheric Infrared Sounder (AIRS) CO2 Retrieval

    NASA Technical Reports Server (NTRS)

    Gat, Ilana

    2012-01-01

    The Atmospheric Infrared Sounder (AIRS) is a thermal infrared sensor able to retrieve the daily atmospheric state globally for clear as well as partially cloudy field-of-views. The AIRS spectrometer has 2378 channels sensing from 15.4 micrometers to 3.7 micrometers, of which a small subset in the 15 micrometers region has been selected, to date, for CO2 retrieval. To improve upon the current retrieval method, we extended the retrieval calculations to include a prior estimate component and developed a channel ranking system to optimize the channels and number of channels used. The channel ranking system uses a mathematical formalism to rapidly process and assess the retrieval potential of large numbers of channels. Implementing this system, we identifed a larger optimized subset of AIRS channels that can decrease retrieval errors and minimize the overall sensitivity to other iridescent contributors, such as water vapor, ozone, and atmospheric temperature. This methodology selects channels globally by accounting for the latitudinal, longitudinal, and seasonal dependencies of the subset. The new methodology increases accuracy in AIRS CO2 as well as other retrievals and enables the extension of retrieved CO2 vertical profiles to altitudes ranging from the lower troposphere to upper stratosphere. The extended retrieval method for CO2 vertical profile estimation using a maximum-likelihood estimation method. We use model data to demonstrate the beneficial impact of the extended retrieval method using the new channel ranking system on CO2 retrieval.

  9. A global sensitivity analysis for African sleeping sickness

    PubMed Central

    DAVIS, STEPHEN; AKSOY, SERAP; GALVANI, ALISON

    2012-01-01

    SUMMARY African sleeping sickness is a parasitic disease transmitted through the bites of tsetse flies of the genus Glossina. We constructed mechanistic models for the basic reproduction number, R0, of Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, respectively the causative agents of West and East African human sleeping sickness. We present global sensitivity analyses of these models that rank the importance of the biological parameters that may explain variation in R0, using parameter ranges based on literature, field data and expertize out of Uganda. For West African sleeping sickness, our results indicate that the proportion of bloodmeals taken from humans by Glossina fuscipes fuscipes is the most important factor, suggesting that differences in the exposure of humans to tsetse are fundamental to the distribution of T. b. gambiense. The second ranked parameter for T. b. gambiense and the highest ranked for T. b. rhodesiense was the proportion of Glossina refractory to infection. This finding underlines the possible implications of recent work showing that nutritionally stressed tsetse are more susceptible to trypanosome infection, and provides broad support for control strategies in development that are aimed at increasing refractoriness in tsetse flies. We note though that for T. b. rhodesiense the population parameters for tsetse – species composition, survival and abundance – were ranked almost as highly as the proportion refractory, and that the model assumed regular treatment of livestock with trypanocides as an established practice in the areas of Uganda experiencing East African sleeping sickness. PMID:21078220

  10. On 3-D modeling and automatic regridding in shape design sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Choi, Kyung K.; Yao, Tse-Min

    1987-01-01

    The material derivative idea of continuum mechanics and the adjoint variable method of design sensitivity analysis are used to obtain a computable expression for the effect of shape variations on measures of structural performance of three-dimensional elastic solids.

  11. Sensitivity Analysis of Parameters Affecting Protection of Water Resources at Hanford WA

    SciTech Connect

    DAVIS, J.D.

    2002-02-08

    The scope of this analysis was to assess the sensitivity of contaminant fluxes from the vadose zone to the water table, to several parameters, some of which can be controlled by operational considerations.

  12. The Effect of Data Scaling on Dual Prices and Sensitivity Analysis in Linear Programs

    ERIC Educational Resources Information Center

    Adlakha, V. G.; Vemuganti, R. R.

    2007-01-01

    In many practical situations scaling the data is necessary to solve linear programs. This note explores the relationships in translating the sensitivity analysis between the original and the scaled problems.

  13. PRELIMINARY TESTING, EVALUATION, AND SENSITIVITY ANALYSIS FOR THE TERRESTRIAL ECOSYSTEM EXPOSURE ASSESSMENT MODEL

    EPA Science Inventory

    This report documents an initial testing and sensitivity analysis of the Terrestrial Ecosystem Exposure Assessment Model (TEEAM). TEEAM calculates the exposure concentrations of contaminants in plants and animals in terrestrial ecosystems. he project was performed in two phases. ...

  14. The application of sensitivity analysis to models of large scale physiological systems

    NASA Technical Reports Server (NTRS)

    Leonard, J. I.

    1974-01-01

    A survey of the literature of sensitivity analysis as it applies to biological systems is reported as well as a brief development of sensitivity theory. A simple population model and a more complex thermoregulatory model illustrate the investigatory techniques and interpretation of parameter sensitivity analysis. The role of sensitivity analysis in validating and verifying models, and in identifying relative parameter influence in estimating errors in model behavior due to uncertainty in input data is presented. This analysis is valuable to the simulationist and the experimentalist in allocating resources for data collection. A method for reducing highly complex, nonlinear models to simple linear algebraic models that could be useful for making rapid, first order calculations of system behavior is presented.

  15. Analysis of additives in dairy products by liquid chromatography coupled to quadrupole-orbitrap mass spectrometry.

    PubMed

    Jia, Wei; Ling, Yun; Lin, Yuanhui; Chang, James; Chu, Xiaogang

    2014-04-01

    A new method combining QuEChERS with ultrahigh-performance liquid chromatography and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC/ESI Q-Orbitrap) was developed for the highly accurate and sensitive screening of 43 antioxidants, preservatives and synthetic sweeteners in dairy products. Response surface methodology was employed to optimize a quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation method for the determination of 42 different analytes in dairy products for the first time. After optimization, the maximum predicted recovery was 99.33% rate for aspartame under the optimized conditions of 10 mL acetionitrile, 1.52 g sodium acetate, 410 mg PSA and 404 mgC18. For the matrices studied, the recovery rates of the other 42 compounds ranged from 89.4% to 108.2%, with coefficient of variation <6.4%. UHPLC/ESI Q-Orbitrap Mass full scan mode acquired full MS data was used to identify and quantify additives, and data-dependent scan mode obtained fragment ion spectra for confirmation. The mass accuracy typically obtained is routinely better than 1.5ppm, and only need to calibrate once a week. The 43 compounds behave dynamic in the range 0.001-1000 μg kg(-1) concentration, with correlation coefficient >0.999. The limits of detection for the analytes are in the range 0.0001-3.6 μg kg(-1). This method has been successfully applied on screening of antioxidants, preservatives and synthetic sweeteners in commercial dairy product samples, and it is very useful for fast screening of different food additives. PMID:24607030

  16. Sensitivity analysis and multidisciplinary optimization for aircraft design - Recent advances and results

    NASA Technical Reports Server (NTRS)

    Sobieszczanski-Sobieski, Jaroslaw

    1988-01-01

    Optimization by decomposition, complex system sensitivity analysis, and a rapid growth of disciplinary sensitivity analysis are some of the recent developments that hold promise of a quantum jump in the support engineers receive from computers in the quantitative aspects of design. Review of the salient points of these techniques is given and illustrated by examples from aircraft design as a process that combines the best of human intellect and computer power to manipulate data.

  17. Sensitivity analysis and multidisciplinary optimization for aircraft design: Recent advances and results

    NASA Technical Reports Server (NTRS)

    Sobieszczanski-Sobieski, Jaroslaw

    1988-01-01

    Optimization by decomposition, complex system sensitivity analysis, and a rapid growth of disciplinary sensitivity analysis are some of the recent developments that hold promise of a quantum jump in the support engineers receive from computers in the quantitative aspects of design. Review of the salient points of these techniques is given and illustrated by examples from aircraft design as a process that combines the best of human intellect and computer power to manipulate data.

  18. Sensitivity and uncertainty analysis applied to the JHR reactivity prediction

    SciTech Connect

    Leray, O.; Vaglio-Gaudard, C.; Hudelot, J. P.; Santamarina, A.; Noguere, G.; Di-Salvo, J.

    2012-07-01

    The on-going AMMON program in EOLE reactor at CEA Cadarache (France) provides experimental results to qualify the HORUS-3D/N neutronics calculation scheme used for the design and safety studies of the new Material Testing Jules Horowitz Reactor (JHR). This paper presents the determination of technological and nuclear data uncertainties on the core reactivity and the propagation of the latter from the AMMON experiment to JHR. The technological uncertainty propagation was performed with a direct perturbation methodology using the 3D French stochastic code TRIPOLI4 and a statistical methodology using the 2D French deterministic code APOLLO2-MOC which leads to a value of 289 pcm (1{sigma}). The Nuclear Data uncertainty propagation relies on a sensitivity study on the main isotopes and the use of a retroactive marginalization method applied to the JEFF 3.1.1 {sup 27}Al evaluation in order to obtain a realistic multi-group covariance matrix associated with the considered evaluation. This nuclear data uncertainty propagation leads to a K{sub eff} uncertainty of 624 pcm for the JHR core and 684 pcm for the AMMON reference configuration core. Finally, transposition and reduction of the prior uncertainty were made using the Representativity method which demonstrates the similarity of the AMMON experiment with JHR (the representativity factor is 0.95). The final impact of JEFF 3.1.1 nuclear data on the Begin Of Life (BOL) JHR reactivity calculated by the HORUS-3D/N V4.0 is a bias of +216 pcm with an associated posterior uncertainty of 304 pcm (1{sigma}). (authors)

  19. Analysis of publically available skin sensitization data from REACH registrations 2008-2014.

    PubMed

    Luechtefeld, Thomas; Maertens, Alexandra; Russo, Daniel P; Rovida, Costanza; Zhu, Hao; Hartung, Thomas

    2016-01-01

    The public data on skin sensitization from REACH registrations already included 19,111 studies on skin sensitization in December 2014, making it the largest repository of such data so far (1,470 substances with mouse LLNA, 2,787 with GPMT, 762 with both in vivo and in vitro and 139 with only in vitro data). 21% were classified as sensitizers. The extracted skin sensitization data was analyzed to identify relationships in skin sensitization guidelines, visualize structural relationships of sensitizers, and build models to predict sensitization. A chemical with molecular weight > 500 Da is generally considered non-sensitizing owing to low bioavailability, but 49 sensitizing chemicals with a molecular weight > 500 Da were found. A chemical similarity map was produced using PubChem's 2D Tanimoto similarity metric and Gephi force layout visualization. Nine clusters of chemicals were identified by Blondel's module recognition algorithm revealing wide module-dependent variation. Approximately 31% of mapped chemicals are Michaell's acceptors but alone this does not imply skin sensitization. A simple sensitization model using molecular weight and five ToxTree structural alerts showed a balanced accuracy of 65.8% (specificity 80.4%, sensitivity 51.4%), demonstrating that structural alerts have information value. A simple variant of k-nearest neighbors outperformed the ToxTree approach even at 75% similarity threshold (82% balanced accuracy at 0.95 threshold). At higher thresholds, the balanced accuracy increased. Lower similarity thresholds decrease sensitivity faster than specificity. This analysis scopes the landscape of chemical skin sensitization, demonstrating the value of large public datasets for health hazard prediction. PMID:26863411

  20. Parameter sensitivity analysis of a simplified electrochemical and thermal model for Li-ion batteries aging

    NASA Astrophysics Data System (ADS)

    Edouard, C.; Petit, M.; Forgez, C.; Bernard, J.; Revel, R.

    2016-09-01

    In this work, a simplified electrochemical and thermal model that can predict both physicochemical and aging behavior of Li-ion batteries is studied. A sensitivity analysis of all its physical parameters is performed in order to find out their influence on the model output based on simulations under various conditions. The results gave hints on whether a parameter needs particular attention when measured or identified and on the conditions (e.g. temperature, discharge rate) under which it is the most sensitive. A specific simulation profile is designed for parameters involved in aging equations in order to determine their sensitivity. Finally, a step-wise method is followed to limit the influence of parameter values when identifying some of them, according to their relative sensitivity from the study. This sensitivity analysis and the subsequent step-wise identification method show very good results, such as a better fitting of the simulated cell voltage with experimental data.

  1. Design component method for sensitivity analysis of built-up structures

    NASA Technical Reports Server (NTRS)

    Choi, Kyung K.; Seong, Hwai G.

    1986-01-01

    A 'design component method' that provides a unified and systematic organization of design sensitivity analysis for built-up structures is developed and implemented. Both conventional design variables, such as thickness and cross-sectional area, and shape design variables of components of built-up structures are considered. It is shown that design of components of built-up structures can be characterized and system design sensitivity expressions obtained by simply adding contributions from each component. The method leads to a systematic organization of computations for design sensitivity analysis that is similar to the way in which computations are organized within a finite element code.

  2. Time domain adjoint sensitivity analysis of electromagnetic problems with nonlinear media.

    PubMed

    Bakr, Mohamed H; Ahmed, Osman S; El Sherif, Mohamed H; Nomura, Tsuyoshi

    2014-05-01

    In this paper, we propose a theory for wideband adjoint sensitivity analysis of problems with nonlinear media. We show that the sensitivities of the desired response with respect to all shape and material parameters are obtained through one extra adjoint simulation. Unlike linear problems, the system matrices of this adjoint simulation are time varying. Their values are determined during the original simulation. The proposed theory exploits the time-domain transmission line modeling (TLM) and provides an efficient AVM approach for sensitivity analysis of general time domain objective functions. The theory has been illustrated through a number of examples. PMID:24921783

  3. Analysis of rate-sensitive skin in gas wells

    SciTech Connect

    Meehan, D.N.; Schell, E.J.

    1983-01-01

    This study documents the analysis of rate dependent skin in a gas well. Three build-up tests and an isochronal test are analyzed in some detail. The results indicate the rate dependent skin is due to non-Darcy flow near the well bore. Evidence is presented that suggest the non-Darcy flow results from calcium carbonate scale partially plugging the perforations. Also, the summary of a pressure build-up study is included on the wells recently drilled in Champlin's Stratton-Agua Dulce field.

  4. An analysis of rate-sensitive skin in gas wells

    SciTech Connect

    Meehan, D.N.; Schell, E.J.

    1983-10-01

    This paper documents the analysis of rate dependent skin in a gas well. Three build-up tests and an isochronal test are analyzed in some detail. The results indicate the rate dependent skin is due to nondarcy flow near the wellbore. Evidence is presented that suggest the non-darcy flow results from calcium carbonate scale partially plugging the perforations. Also, the summary of a pressure build-up study is included on the wells recently drilled in Champlin's Stratton-Agua Dulce Field.

  5. Methodology for Sensitivity Analysis, Approximate Analysis, and Design Optimization in CFD for Multidisciplinary Applications

    NASA Technical Reports Server (NTRS)

    Taylor, Arthur C., III; Hou, Gene W.

    1996-01-01

    An incremental iterative formulation together with the well-known spatially split approximate-factorization algorithm, is presented for solving the large, sparse systems of linear equations that are associated with aerodynamic sensitivity analysis. This formulation is also known as the 'delta' or 'correction' form. For the smaller two dimensional problems, a direct method can be applied to solve these linear equations in either the standard or the incremental form, in which case the two are equivalent. However, iterative methods are needed for larger two-dimensional and three dimensional applications because direct methods require more computer memory than is currently available. Iterative methods for solving these equations in the standard form are generally unsatisfactory due to an ill-conditioned coefficient matrix; this problem is overcome when these equations are cast in the incremental form. The methodology is successfully implemented and tested using an upwind cell-centered finite-volume formulation applied in two dimensions to the thin-layer Navier-Stokes equations for external flow over an airfoil. In three dimensions this methodology is demonstrated with a marching-solution algorithm for the Euler equations to calculate supersonic flow over the High-Speed Civil Transport configuration (HSCT 24E). The sensitivity derivatives obtained with the incremental iterative method from a marching Euler code are used in a design-improvement study of the HSCT configuration that involves thickness. camber, and planform design variables.

  6. A Fully Non-Metallic Gas Turbine Engine Enabled by Additive Manufacturing Part I: System Analysis, Component Identification, Additive Manufacturing, and Testing of Polymer Composites

    NASA Technical Reports Server (NTRS)

    Grady, Joseph E.; Haller, William J.; Poinsatte, Philip E.; Halbig, Michael C.; Schnulo, Sydney L.; Singh, Mrityunjay; Weir, Don; Wali, Natalie; Vinup, Michael; Jones, Michael G.; Patterson, Clark; Santelle, Tom; Mehl, Jeremy

    2015-01-01

    The research and development activities reported in this publication were carried out under NASA Aeronautics Research Institute (NARI) funded project entitled "A Fully Nonmetallic Gas Turbine Engine Enabled by Additive Manufacturing." The objective of the project was to conduct evaluation of emerging materials and manufacturing technologies that will enable fully nonmetallic gas turbine engines. The results of the activities are described in three part report. The first part of the report contains the data and analysis of engine system trade studies, which were carried out to estimate reduction in engine emissions and fuel burn enabled due to advanced materials and manufacturing processes. A number of key engine components were identified in which advanced materials and additive manufacturing processes would provide the most significant benefits to engine operation. The technical scope of activities included an assessment of the feasibility of using additive manufacturing technologies to fabricate gas turbine engine components from polymer and ceramic matrix composites, which were accomplished by fabricating prototype engine components and testing them in simulated engine operating conditions. The manufacturing process parameters were developed and optimized for polymer and ceramic composites (described in detail in the second and third part of the report). A number of prototype components (inlet guide vane (IGV), acoustic liners, engine access door) were additively manufactured using high temperature polymer materials. Ceramic matrix composite components included turbine nozzle components. In addition, IGVs and acoustic liners were tested in simulated engine conditions in test rigs. The test results are reported and discussed in detail.

  7. What do we mean by sensitivity analysis? The need for comprehensive characterization of "global" sensitivity in Earth and Environmental systems models

    NASA Astrophysics Data System (ADS)

    Razavi, Saman; Gupta, Hoshin V.

    2015-05-01

    Sensitivity analysis is an essential paradigm in Earth and Environmental Systems modeling. However, the term "sensitivity" has a clear definition, based in partial derivatives, only when specified locally around a particular point (e.g., optimal solution) in the problem space. Accordingly, no unique definition exists for "global sensitivity" across the problem space, when considering one or more model responses to different factors such as model parameters or forcings. A variety of approaches have been proposed for global sensitivity analysis, based on different philosophies and theories, and each of these formally characterizes a different "intuitive" understanding of sensitivity. These approaches focus on different properties of the model response at a fundamental level and may therefore lead to different (even conflicting) conclusions about the underlying sensitivities. Here we revisit the theoretical basis for sensitivity analysis, summarize and critically evaluate existing approaches in the literature, and demonstrate their flaws and shortcomings through conceptual examples. We also demonstrate the difficulty involved in interpreting "global" interaction effects, which may undermine the value of existing interpretive approaches. With this background, we identify several important properties of response surfaces that are associated with the understanding and interpretation of sensitivities in the context of Earth and Environmental System models. Finally, we highlight the need for a new, comprehensive framework for sensitivity analysis that effectively characterizes all of the important sensitivity-related properties of model response surfaces.

  8. Sensitivity analysis for premixed, laminar, steady-state flames. Technical report

    SciTech Connect

    Coffee, T.P.; Heimerl, J.M.

    1983-01-01

    A procedure has been developed to perform a sensitivity analysis on the transport and rate input parameters for a premixed, laminar, one-dimensional, steady-state flame. Computer codes exist to perform the sensitivity analysis automatically. The analysis can be done in terms of Taylor expansions or Logarithmic expansions. Both first and second order coefficients may be computed. As a test case, the analysis has been carried out for a set of H2/O2/N2/flames. The relative accuracy and the range of validity of the various expansions is discussed.

  9. Eigenvalue and eigenvector sensitivity and approximate analysis for repeated eigenvalue problems

    NASA Technical Reports Server (NTRS)

    Hou, Gene J. W.; Kenny, Sean P.

    1991-01-01

    A set of computationally efficient equations for eigenvalue and eigenvector sensitivity analysis are derived, and a method for eigenvalue and eigenvector approximate analysis in the presence of repeated eigenvalues is presented. The method developed for approximate analysis involves a reparamaterization of the multivariable structural eigenvalue problem in terms of a single positive-valued parameter. The resulting equations yield first-order approximations of changes in both the eigenvalues and eigenvectors associated with the repeated eigenvalue problem. Examples are given to demonstrate the application of such equations for sensitivity and approximate analysis.

  10. LSENS: A General Chemical Kinetics and Sensitivity Analysis Code for homogeneous gas-phase reactions. Part 3: Illustrative test problems

    NASA Technical Reports Server (NTRS)

    Bittker, David A.; Radhakrishnan, Krishnan

    1994-01-01

    LSENS, the Lewis General Chemical Kinetics and Sensitivity Analysis Code, has been developed for solving complex, homogeneous, gas-phase chemical kinetics problems and contains sensitivity analysis for a variety of problems, including nonisothermal situations. This report is part 3 of a series of three reference publications that describe LSENS, provide a detailed guide to its usage, and present many example problems. Part 3 explains the kinetics and kinetics-plus-sensitivity analysis problems supplied with LSENS and presents sample results. These problems illustrate the various capabilities of, and reaction models that can be solved by, the code and may provide a convenient starting point for the user to construct the problem data file required to execute LSENS. LSENS is a flexible, convenient, accurate, and efficient solver for chemical reaction problems such as static system; steady, one-dimensional, inviscid flow; reaction behind incident shock wave, including boundary layer correction; and perfectly stirred (highly backmixed) reactor. In addition, the chemical equilibrium state can be computed for the following assigned states: temperature and pressure, enthalpy and pressure, temperature and volume, and internal energy and volume. For static problems the code computes the sensitivity coefficients of the dependent variables and their temporal derivatives with respect to the initial values of the dependent variables and/or the three rate coefficient parameters of the chemical reactions.

  11. Importance analysis for Hudson River PCB transport and fate model parameters using robust sensitivity studies

    SciTech Connect

    Zhang, S.; Toll, J.; Cothern, K.

    1995-12-31

    The authors have performed robust sensitivity studies of the physico-chemical Hudson River PCB model PCHEPM to identify the parameters and process uncertainties contributing the most to uncertainty in predictions of water column and sediment PCB concentrations, over the time period 1977--1991 in one segment of the lower Hudson River. The term ``robust sensitivity studies`` refers to the use of several sensitivity analysis techniques to obtain a more accurate depiction of the relative importance of different sources of uncertainty. Local sensitivity analysis provided data on the sensitivity of PCB concentration estimates to small perturbations in nominal parameter values. Range sensitivity analysis provided information about the magnitude of prediction uncertainty associated with each input uncertainty. Rank correlation analysis indicated which parameters had the most dominant influence on model predictions. Factorial analysis identified important interactions among model parameters. Finally, term analysis looked at the aggregate influence of combinations of parameters representing physico-chemical processes. The authors scored the results of the local and range sensitivity and rank correlation analyses. The authors considered parameters that scored high on two of the three analyses to be important contributors to PCB concentration prediction uncertainty, and treated them probabilistically in simulations. They also treated probabilistically parameters identified in the factorial analysis as interacting with important parameters. The authors used the term analysis to better understand how uncertain parameters were influencing the PCB concentration predictions. The importance analysis allowed us to reduce the number of parameters to be modeled probabilistically from 16 to 5. This reduced the computational complexity of Monte Carlo simulations, and more importantly, provided a more lucid depiction of prediction uncertainty and its causes.

  12. Meta-analysis of the relative sensitivity of semi-natural vegetation species to ozone.

    PubMed

    Hayes, F; Jones, M L M; Mills, G; Ashmore, M

    2007-04-01

    This study identified 83 species from existing publications suitable for inclusion in a database of sensitivity of species to ozone (OZOVEG database). An index, the relative sensitivity to ozone, was calculated for each species based on changes in biomass in order to test for species traits associated with ozone sensitivity. Meta-analysis of the ozone sensitivity data showed a wide inter-specific range in response to ozone. Some relationships in comparison to plant physiological and ecological characteristics were identified. Plants of the therophyte lifeform were particularly sensitive to ozone. Species with higher mature leaf N concentration were more sensitive to ozone than those with lower leaf N concentration. Some relationships between relative sensitivity to ozone and Ellenberg habitat requirements were also identified. In contrast, no relationships between relative sensitivity to ozone and mature leaf P concentration, Grime's CSR strategy, leaf longevity, flowering season, stomatal density and maximum altitude were found. The relative sensitivity of species and relationships with plant characteristics identified in this study could be used to predict sensitivity to ozone of untested species and communities. PMID:16899330

  13. Comparison of three different methods for global sensitivity analysis - application to a complex environmental model

    NASA Astrophysics Data System (ADS)

    Werisch, Stefan; Krause, Julia

    2014-05-01

    Complex environmental models which are able to consider the dynamic interactions between plants, soils and the environment are suitable tools to predict the impact of climate variability and climate change on the water budget of small catchments. Unfortunately increases the number of potential calibration parameters with increasing complexity of these models. Methods of global sensitivity analysis (GSA) are considered as helpful tools to identify the sensitive and therefore relevant model parameters which need to be considered in the optimization process. To assess the efficiency of these approaches, three different methods for GSA of model parameters, namely: (1) Mutual Entropy (ME), (2) Regional Sensitivity Analysis and (3) enhanced Fourier Amplitude Sensitivity Test (eFAST) have been tested and compared using the complex environmental model SWAP. The model was set up to simulate the water budget and soil water dynamics of a small experimental catchment in the Ore Mountains, Germany. Discharge and soil water content time series established the data basis for the sensitivity analysis. All three methods have been applied to investigate the sensitivity of the model parameters regarding the different data types, different model efficiency measures and different time resolutions for the calculation of the efficiency measures. The results indicate that GSA methods from which only the first order sensitivities, this means the sole influence of a specific parameter on the model output, can be obtained (ME & RSA) are unsuitable for complex environmental models. They identified less than 20% of the model parameters to be sensitive, while almost 80% of the model parameters were identified as sensitive on the basis of the total sensitivity index calculated by the eFAST method. Possible reasons for the failure of the first-order methods are the strong interactions of the parameters and the non-linear behavior of the model. A second important result of this study is that

  14. Least Squares Shadowing Sensitivity Analysis of Chaotic Flow Around a Two-Dimensional Airfoil

    NASA Technical Reports Server (NTRS)

    Blonigan, Patrick J.; Wang, Qiqi; Nielsen, Eric J.; Diskin, Boris

    2016-01-01

    Gradient-based sensitivity analysis has proven to be an enabling technology for many applications, including design of aerospace vehicles. However, conventional sensitivity analysis methods break down when applied to long-time averages of chaotic systems. This breakdown is a serious limitation because many aerospace applications involve physical phenomena that exhibit chaotic dynamics, most notably high-resolution large-eddy and direct numerical simulations of turbulent aerodynamic flows. A recently proposed methodology, Least Squares Shadowing (LSS), avoids this breakdown and advances the state of the art in sensitivity analysis for chaotic flows. The first application of LSS to a chaotic flow simulated with a large-scale computational fluid dynamics solver is presented. The LSS sensitivity computed for this chaotic flow is verified and shown to be accurate, but the computational cost of the current LSS implementation is high.

  15. Mass analysis addition to the Differential Ion Flux Probe (DIFP) study

    NASA Technical Reports Server (NTRS)

    Wright, K. H., Jr.; Jolley, Richard

    1994-01-01

    The objective of this study is to develop a technique to measure the characteristics of space plasmas under highly disturbed conditions; e.g., non-Maxwellian plasmas with strong drifting populations and plasmas contaminated by spacecraft outgassing. The approach, conducted in conjunction with current MSFC activities, is to extend the capabilities of the Differential Ion Flux Probe (DIFP) to include a high throughput mass measurement that does not require either high voltage or contamination sensitive devices such as channeltron electron multipliers or microchannel plates. This will significantly reduce the complexity and expense of instrument fabrication, testing, and integration of flight hardware compared to classical mass analyzers. The feasibility of the enhanced DIFP has been verified by using breadboard test models in a controlled plasma environment. The ability to manipulate particles through the instrument regardless of incident angle, energy, or ionic component has been amply demonstrated. The energy analysis mode is differential and leads directly to a time-of-flight mass measurement. With the new design, the DIFP will separate multiple ion streams and analyze each stream independently for ion flux intensity, velocity (including direction of motion), mass, and temperature (or energy distribution). In particular, such an instrument will be invaluable on follow-on electrodynamic TSS missions and, possibly, for environmental monitoring on the space station.

  16. Numerical simulations of snowfall events: Sensitivity analysis of physical parameterizations

    NASA Astrophysics Data System (ADS)

    Fernández-González, S.; Valero, F.; Sánchez, J. L.; Gascón, E.; López, L.; García-Ortega, E.; Merino, A.

    2015-10-01

    Accurate estimation of snowfall episodes several hours or even days in advance is essential to minimize risks to transport and other human activities. Every year, these episodes cause severe traffic problems on the northwestern Iberian Peninsula. In order to analyze the influence of different parameterization schemes, 15 snowfall days were analyzed with the Weather Research and Forecasting (WRF) model, defining three nested domains with resolutions of 27, 9, and 3 km. We implemented four microphysical parameterizations (WRF Single-Moment 6-class scheme, Goddard, Thompson, and Morrison) and two planetary boundary layer schemes (Yonsei University and Mellor-Yamada-Janjic), yielding eight distinct combinations. To validate model estimates, a network of 97 precipitation gauges was used, together with dichotomous data of snowfall presence/absence from snowplow requests to the emergency service of Spain and observatories of the Spanish Meteorological Agency. The results indicate that the most accurate setting of WRF for the study area was that using the Thompson microphysical parameterization and Mellor-Yamada-Janjic scheme, although the Thompson and Yonsei University combination had greater accuracy in determining the temporal distribution of precipitation over 1 day. Combining the eight deterministic members in an ensemble average improved results considerably. Further, the root mean square difference decreased markedly using a multiple linear regression as postprocessing. In addition, our method was able to provide mean ensemble precipitation and maximum expected precipitation,which can be very useful in the management of water resources. Finally, we developed an application that allows determination of the risk of snowfall above a certain threshold.

  17. Biomechanical modeling and sensitivity analysis of bipedal running ability. II. Extinct taxa.

    PubMed

    Hutchinson, John R

    2004-10-01

    Using an inverse dynamics biomechanical analysis that was previously validated for extant bipeds, I calculated the minimum amount of actively contracting hindlimb extensor muscle that would have been needed for rapid bipedal running in several extinct dinosaur taxa. I analyzed models of nine theropod dinosaurs (including birds) covering over five orders of magnitude in size. My results uphold previous findings that large theropods such as Tyrannosaurus could not run very quickly, whereas smaller theropods (including some extinct birds) were adept runners. Furthermore, my results strengthen the contention that many nonavian theropods, especially larger individuals, used fairly upright limb orientations, which would have reduced required muscular force, and hence muscle mass. Additional sensitivity analysis of muscle fascicle lengths, moment arms, and limb orientation supports these conclusions and points out directions for future research on the musculoskeletal limits on running ability. Although ankle extensor muscle support is shown to have been important for all taxa, the ability of hip extensor muscles to support the body appears to be a crucial limit for running capacity in larger taxa. I discuss what speeds were possible for different theropod dinosaurs, and how running ability evolved in an inverse relationship to body size in archosaurs. PMID:15352202

  18. EH AND S ANALYSIS OF DYE-SENSITIZED PHOTOVOLTAIC SOLAR CELL PRODUCTION.

    SciTech Connect

    BOWERMAN,B.; FTHENAKIS,V.

    2001-10-01

    Photovoltaic solar cells based on a dye-sensitized nanocrystalline titanium dioxide photoelectrode have been researched and reported since the early 1990's. Commercial production of dye-sensitized photovoltaic solar cells has recently been reported in Australia. In this report, current manufacturing methods are described, and estimates are made of annual chemical use and emissions during production. Environmental, health and safety considerations for handling these materials are discussed. This preliminary EH and S evaluation of dye-sensitized titanium dioxide solar cells indicates that some precautions will be necessary to mitigate hazards that could result in worker exposure. Additional information required for a more complete assessment is identified.

  19. Results of an integrated structure/control law design sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Gilbert, Michael G.

    1989-01-01

    A design sensitivity analysis method for Linear Quadratic Cost, Gaussian (LQG) optimal control laws, which predicts change in the optimal control law due to changes in fixed problem parameters using analytical sensitivity equations is discussed. Numerical results of a design sensitivity analysis for a realistic aeroservoelastic aircraft example are presented. In this example, the sensitivity of the optimally controlled aircraft's response to various problem formulation and physical aircraft parameters is determined. These results are used to predict the aircraft's new optimally controlled response if the parameter was to have some other nominal value during the control law design process. The sensitivity results are validated by recomputing the optimal control law for discrete variations in parameters, computing the new actual aircraft response, and comparing with the predicted response. These results show an improvement in sensitivity accuracy for integrated design purposes over methods which do not include changes in the optimal control law. Use of the analytical LQG sensitivity expressions is also shown to be more efficient than finite difference methods for the computation of the equivalent sensitivity information.

  20. Adjoint sensitivity analysis for a three-dimensional photochemical model: implementation and method comparison.

    PubMed

    Martien, Philip T; Harley, Robert A; Cacuci, Dan G

    2006-04-15

    Photochemical air pollution forms when emissions of nitrogen oxides (NO(x)) and volatile organic compounds (VOC) react in the atmosphere in the presence of sunlight. The goal of applying three-dimensional photochemical air quality models is usually to conduct sensitivity analysis: for example, to predict changes in an ozone response due to changes in NO(x) and VOC emissions or other model data. Forward sensitivity analysis methods are best suited to investigating sensitivities of many model responses to changes in a few inputs or parameters. Here we develop a continuous adjoint model and demonstrate an adjoint sensitivity analysis procedure that is well-suited to the complementary case of determining sensitivity of a small number of model responses to many parameters. Sensitivities generated using the adjoint method agree with those generated using other methods. Compared to the forward method, the adjoint method had large disk storage requirements but was more efficient in terms of computer processor time for receptor-based investigations focused on a single response at a specified site and time. The adjoint method also generates sensitivity apportionment fields, which reveal when and where model data are important to the target response. PMID:16683606

  1. Sensitivity analysis of groundwater level in Jinci Spring Basin (China) based on artificial neural network modeling

    NASA Astrophysics Data System (ADS)

    Li, Xian; Shu, Longcang; Liu, Lihong; Yin, Dan; Wen, Jinmei

    2012-06-01

    Jinci Spring in Shanxi, north China, is a major local water source. It dried up in April 1994 due to groundwater overexploitation. The groundwater system is complex, involving many nonlinear and uncertain factors. Artificial neural network (ANN) models are statistical techniques to study parameter nonlinear relationships of groundwater systems. However, ANN models offer little explanatory insight into the mechanisms of prediction models. Sensitivity analysis can overcome this shortcoming. In this study, a back-propagation neural network model was built based on the relationship between groundwater level and its sensitivity factors in Jinci Spring Basin; these sensitivity factors included precipitation, river seepage, mining drainage, groundwater withdrawals and lateral discharge to the associated Quaternary aquifer. All the sensitivity factors were analyzed with Garson's algorithm based on the connection weights of the neural network model. The concept of "sensitivity range" was proposed to describe the value range of the input variables to which the output variables are most sensitive. The sensitivity ranges were analyzed by a local sensitivity approach. The results showed that coal mining drainage is the most sensitive anthropogenic factor, having a large effect on groundwater level of the Jinci Spring Basin.

  2. Dynamics and sensitivity analysis of high-frequency conduction block

    NASA Astrophysics Data System (ADS)

    Ackermann, D. Michael; Bhadra, Niloy; Gerges, Meana; Thomas, Peter J.

    2011-10-01

    The local delivery of extracellular high-frequency stimulation (HFS) has been shown to be a fast acting and quickly reversible method of blocking neural conduction and is currently being pursued for several clinical indications. However, the mechanism for this type of nerve block remains unclear. In this study, we investigate two hypotheses: (1) depolarizing currents promote conduction block via inactivation of sodium channels and (2) the gating dynamics of the fast sodium channel are the primary determinate of minimal blocking frequency. Hypothesis 1 was investigated using a combined modeling and experimental study to investigate the effect of depolarizing and hyperpolarizing currents on high-frequency block. The results of the modeling study show that both depolarizing and hyperpolarizing currents play an important role in conduction block and that the conductance to each of three ionic currents increases relative to resting values during HFS. However, depolarizing currents were found to promote the blocking effect, and hyperpolarizing currents were found to diminish the blocking effect. Inward sodium currents were larger than the sum of the outward currents, resulting in a net depolarization of the nodal membrane. Our experimental results support these findings and closely match results from the equivalent modeling scenario: intra-peritoneal administration of the persistent sodium channel blocker ranolazine resulted in an increase in the amplitude of HFS required to produce conduction block in rats, confirming that depolarizing currents promote the conduction block phenomenon. Hypothesis 2 was investigated using a spectral analysis of the channel gating variables in a single-fiber axon model. The results of this study suggested a relationship between the dynamical properties of specific ion channel gating elements and the contributions of corresponding conductances to block onset. Specifically, we show that the dynamics of the fast sodium inactivation gate are

  3. Dynamics and sensitivity analysis of high frequency conduction block

    PubMed Central

    Ackermann, D. Michael; Bhadra, Niloy; Gerges, Meana; Thomas, Peter J.

    2012-01-01

    The local delivery of extracellular high frequency stimulation (HFS) has been shown to be a fast acting and quickly reversible method of blocking neural conduction, and is currently being pursued for several clinical indications. However, the mechanism for this type of nerve block remains unclear. In this study, we investigate two hypotheses: 1) That depolarizing currents promote conduction block via inactivation of sodium channels, and 2) that the gating dynamics of the fast sodium channel are the primary determinate of minimal blocking frequency. Hypothesis 1 was investigated using a combined modeling and experimental study to investigate the effect of depolarizing and hyperpolarizing currents on high frequency block. The results of the modeling study show that both depolarizing and hyperpolarizing currents play an important role in conduction block and that the conductance to each of three ionic currents increases relative to resting values during HFS. However, depolarizing currents were found to promote the blocking effect, and hyperpolarizing currents were found to diminish the blocking effect. Inward sodium currents were larger than the sum of the outward currents, resulting in a net depolarization of the nodal membrane. Our experimental results support these findings and closely match results from the equivalent modeling scenario: intra-peritoneal administration of the persistent sodium channel blocker ranolazine resulted in an increase in the amplitude of HFS required to produce conduction block in rats, confirming that depolarizing currents promote the conduction block phenomenon. Hypothesis 2 was investigated using a spectral analysis of the channel gating variables in a single fiber axon model. The results of this study suggested a relationship between the dynamical properties of specific ion channel gating elements and the contributions of corresponding conductances to block onset. Specifically, we show that the dynamics of the fast sodium inactivation

  4. Combined probabilistic and principal component analysis approach for multivariate sensitivity evaluation and application to implanted patellofemoral mechanics.

    PubMed

    Fitzpatrick, Clare K; Baldwin, Mark A; Rullkoetter, Paul J; Laz, Peter J

    2011-01-01

    Many aspects of biomechanics are variable in nature, including patient geometry, joint mechanics, implant alignment and clinical outcomes. Probabilistic methods have been applied in computational models to predict distributions of performance given uncertain or variable parameters. Sensitivity analysis is commonly used in conjunction with probabilistic methods to identify the parameters that most significantly affect the performance outcome; however, it does not consider coupled relationships for multiple output measures. Principal component analysis (PCA) has been applied to characterize common modes of variation in shape and kinematics. In this study, a novel, combined probabilistic and PCA approach was developed to characterize relationships between multiple input parameters and output measures. To demonstrate the benefits of the approach, it was applied to implanted patellofemoral (PF) mechanics to characterize relationships between femoral and patellar component alignment and loading and the resulting joint mechanics. Prior studies assessing PF sensitivity have performed individual perturbation of alignment parameters. However, the probabilistic and PCA approach enabled a more holistic evaluation of sensitivity, including identification of combinations of alignment parameters that most significantly contributed to kinematic and contact mechanics outcomes throughout the flexion cycle, and the predictive capability to estimate joint mechanics based on alignment conditions without requiring additional analysis. The approach showed comparable results for Monte Carlo sampling with 500 trials and the more efficient Latin Hypercube sampling with 50 trials. The probabilistic and PCA approach has broad applicability to biomechanical analysis and can provide insight into the interdependencies between implant design, alignment and the resulting mechanics. PMID:20825941

  5. Probabilistic approach to identify sensitive parameter distributions in multimedia pathway analysis.

    SciTech Connect

    Kamboj, S.; Gnanapragasam, E.; LePoire, D.; Biwer, B. M.; Cheng, J.; Arnish, J.; Yu, C.; Chen, S. Y.; Mo, T.; Abu-Eid, R.; Thaggard, M.; Environmental Assessment; NRC

    2002-01-01

    Sensitive parameter distributions were identified with the use of probabilistic analysis in the RESRAD computer code. RESRAD is a multimedia pathway analysis code designed to evaluate radiological exposures resulting from radiological contamination in soil. The dose distribution was obtained by using a set of default parameter distribution/values. Most of the variations in the output dose distribution could be attributed to uncertainty in a small set of input parameters that could be considered as sensitive parameter distributions. The identification of the sensitive parameters is a first step in the prioritization of future research and information gathering. When site-specific parameter distribution/values are available for an actual site, the same process should be used with these site-specific data. Regression analysis used to identify sensitive parameters indicated that the dominant pathways depended on the radionuclide and source configurations. However, two parameter distributions were sensitive for many radionuclides: the external shielding factor when external exposure was the dominant pathway and the plant transfer factor when plant ingestion was the dominant pathway. No single correlation or regression coefficient can be used alone to identify sensitive parameters in all the cases. The coefficients are useful guides, but they have to be used in conjunction with other aids, such as scatter plots, and should undergo further analysis.

  6. Warming and drying of the eastern Mediterranean: Additional evidence from trend analysis

    NASA Astrophysics Data System (ADS)

    Shohami, David; Dayan, Uri; Morin, Efrat

    2011-11-01

    The climate of the eastern Mediterranean (EM), at the transition zone between the Mediterranean climate and the semi-arid/arid climate, has been studied for a 39-year period to determine whether climate changes have taken place. A thorough trend analysis using the nonparametric Mann-Kendall test with Sen's slope estimator has been applied to ground station measurements, atmospheric reanalysis data, synoptic classification data and global data sets for the years 1964-2003. In addition, changes in atmospheric regional patterns between the first and last twenty years were determined by visual comparisons of their composite mean. The main findings of the analysis are: 1) changes of atmospheric conditions during summer and the transitional seasons (mainly autumn) support a warmer climate over the EM and this change is already statistically evident in surface temperatures having exhibited positive trends of 0.2-1°C/decade; 2) changes of atmospheric conditions during winter and the transitional seasons support drier conditions due to reduction in cyclogenesis and specific humidity over the EM, but this change is not yet statistically evident in surface station rain data, presumably because of the high natural precipitation variance masking such a change. The overall conclusion of this study is that the EM region is under climate change leading to warmer and drier conditions.

  7. A Comparative Review of Sensitivity and Uncertainty Analysis of Large-Scale Systems - II: Statistical Methods

    SciTech Connect

    Cacuci, Dan G.; Ionescu-Bujor, Mihaela

    2004-07-15

    Part II of this review paper highlights the salient features of the most popular statistical methods currently used for local and global sensitivity and uncertainty analysis of both large-scale computational models and indirect experimental measurements. These statistical procedures represent sampling-based methods (random sampling, stratified importance sampling, and Latin Hypercube sampling), first- and second-order reliability algorithms (FORM and SORM, respectively), variance-based methods (correlation ratio-based methods, the Fourier Amplitude Sensitivity Test, and the Sobol Method), and screening design methods (classical one-at-a-time experiments, global one-at-a-time design methods, systematic fractional replicate designs, and sequential bifurcation designs). It is emphasized that all statistical uncertainty and sensitivity analysis procedures first commence with the 'uncertainty analysis' stage and only subsequently proceed to the 'sensitivity analysis' stage; this path is the exact reverse of the conceptual path underlying the methods of deterministic sensitivity and uncertainty analysis where the sensitivities are determined prior to using them for uncertainty analysis. By comparison to deterministic methods, statistical methods for uncertainty and sensitivity analysis are relatively easier to develop and use but cannot yield exact values of the local sensitivities. Furthermore, current statistical methods have two major inherent drawbacks as follows: 1. Since many thousands of simulations are needed to obtain reliable results, statistical methods are at best expensive (for small systems) or, at worst, impracticable (e.g., for large time-dependent systems).2. Since the response sensitivities and parameter uncertainties are inherently and inseparably amalgamated in the results produced by these methods, improvements in parameter uncertainties cannot be directly propagated to improve response uncertainties; rather, the entire set of simulations and

  8. Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays.

    PubMed

    Tsujita-Inoue, Kyoko; Hirota, Morihiko; Ashikaga, Takao; Atobe, Tomomi; Kouzuki, Hirokazu; Aiba, Setsuya

    2014-06-01

    The sensitizing potential of chemicals is usually identified and characterized using in vivo methods such as the murine local lymph node assay (LLNA). Due to regulatory constraints and ethical concerns, alternatives to animal testing are needed to predict skin sensitization potential of chemicals. For this purpose, combined evaluation using multiple in vitro and in silico parameters that reflect different aspects of the sensitization process seems promising. We previously reported that LLNA thresholds could be well predicted by using an artificial neural network (ANN) model, designated iSENS ver.1 (integrating in vitro sensitization tests version 1), to analyze data obtained from two in vitro tests: the human Cell Line Activation Test (h-CLAT) and the SH test. Here, we present a more advanced ANN model, iSENS ver.2, which additionally utilizes the results of antioxidant response element (ARE) assay and the octanol-water partition coefficient (LogP, reflecting lipid solubility and skin absorption). We found a good correlation between predicted LLNA thresholds calculated by iSENS ver.2 and reported values. The predictive performance of iSENS ver.2 was superior to that of iSENS ver.1. We conclude that ANN analysis of data from multiple in vitro assays is a useful approach for risk assessment of chemicals for skin sensitization. PMID:24444449

  9. A damage identification technique based on embedded sensitivity analysis and optimization processes

    NASA Astrophysics Data System (ADS)

    Yang, Chulho; Adams, Douglas E.

    2014-07-01

    A vibration based structural damage identification method, using embedded sensitivity functions and optimization algorithms, is discussed in this work. The embedded sensitivity technique requires only measured or calculated frequency response functions to obtain the sensitivity of system responses to each component parameter. Therefore, this sensitivity analysis technique can be effectively used for the damage identification process. Optimization techniques are used to minimize the difference between the measured frequency response functions of the damaged structure and those calculated from the baseline system using embedded sensitivity functions. The amount of damage can be quantified directly in engineering units as changes in stiffness, damping, or mass. Various factors in the optimization process and structural dynamics are studied to enhance the performance and robustness of the damage identification process. This study shows that the proposed technique can improve the accuracy of damage identification with less than 2 percent error of estimation.

  10. A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome[S

    PubMed Central

    Liu, Wei; Xu, Libin; Lamberson, Connor; Haas, Dorothea; Korade, Zeljka; Porter, Ned A.

    2014-01-01

    We describe a highly sensitive method for the detection of 7-dehydrocholesterol (7-DHC), the biosynthetic precursor of cholesterol, based on its reactivity with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) in a Diels-Alder cycloaddition reaction. Samples of biological tissues and fluids with added deuterium-labeled internal standards were derivatized with PTAD and analyzed by LC-MS. This protocol permits fast processing of samples, short chromatography times, and high sensitivity. We applied this method to the analysis of cells, blood, and tissues from several sources, including human plasma. Another innovative aspect of this study is that it provides a reliable and highly reproducible measurement of 7-DHC in 7-dehydrocholesterol reductase (Dhcr7)-HET mouse (a model for Smith-Lemli-Opitz syndrome) samples, showing regional differences in the brain tissue. We found that the levels of 7-DHC are consistently higher in Dhcr7-HET mice than in controls, with the spinal cord and peripheral nerve showing the biggest differences. In addition to 7-DHC, sensitive analysis of desmosterol in tissues and blood was also accomplished with this PTAD method by assaying adducts formed from the PTAD “ene” reaction. The method reported here may provide a highly sensitive and high throughput way to identify at-risk populations having errors in cholesterol biosynthesis. PMID:24259532

  11. A guide to uncertainty quantification and sensitivity analysis for cardiovascular applications.

    PubMed

    Eck, Vinzenz Gregor; Donders, Wouter Paulus; Sturdy, Jacob; Feinberg, Jonathan; Delhaas, Tammo; Hellevik, Leif Rune; Huberts, Wouter

    2016-08-01

    As we shift from population-based medicine towards a more precise patient-specific regime guided by predictions of verified and well-established cardiovascular models, an urgent question arises: how sensitive are the model predictions to errors and uncertainties in the model inputs? To make our models suitable for clinical decision-making, precise knowledge of prediction reliability is of paramount importance. Efficient and practical methods for uncertainty quantification (UQ) and sensitivity analysis (SA) are therefore essential. In this work, we explain the concepts of global UQ and global, variance-based SA along with two often-used methods that are applicable to any model without requiring model implementation changes: Monte Carlo (MC) and polynomial chaos (PC). Furthermore, we propose a guide for UQ and SA according to a six-step procedure and demonstrate it for two clinically relevant cardiovascular models: model-based estimation of the fractional flow reserve (FFR) and model-based estimation of the total arterial compliance (CT ). Both MC and PC produce identical results and may be used interchangeably to identify most significant model inputs with respect to uncertainty in model predictions of FFR and CT . However, PC is more cost-efficient as it requires an order of magnitude fewer model evaluations than MC. Additionally, we demonstrate that targeted reduction of uncertainty in the most significant model inputs reduces the uncertainty in the model predictions efficiently. In conclusion, this article offers a practical guide to UQ and SA to help move the clinical application of mathematical models forward. Copyright © 2015 John Wiley & Sons, Ltd. PMID:26475178

  12. Benefits of probabilistic sensitivity analysis – a review of NICE decisions

    PubMed Central

    Adalsteinsson, Erpur; Toumi, Mondher

    2013-01-01

    Objective Since 2004, the National Institute of Health and Clinical Excellence (NICE) has required manufacturers to conduct a probabilistic sensitivity analysis (PSA) in their technology appraisals. The objective of this review is to assess the cost-effectiveness of different technology appraisals and compare them with the actual decision made by the NICE based on PSA. Methods The search term ‘probabilistic sensitivity analysis’ was used on the NICE home page (25 January 2012). The appraisals identified in the search were assessed and subjected to further review, if a probability of being cost-effective was provided, regardless of the threshold indicated. If several probabilities were provided, the number provided by the evidence review group was used. If several scenarios were presented, the base case scenario was chosen. Finally, the probabilities of being cost-effective were compared with the actual decision made, which could result in two outcomes: recommended or not recommended. Results A total of 31 assessments were included for the final review. The results were plotted on a graph to illustrate whether there was a relationship between the PSA outcomes and the final recommendation. The assessments were ranked according to their probability of being cost-effective. Conclusion A higher probability of a technology being cost-effective was correlated with more positive decision-making. There appeared to be a clear threshold at which technologies with a 40% certainty of being cost-effective tended to be recommended, whereas those below the threshold were not recommended. The reports suggested that the incremental cost-effectiveness ratios (ICER) estimate was not a robust driver of decision-making. A NICE applicant should pay increased attention to the PSA in addition to the ICER estimate.

  13. Fast and sensitive recognition of various explosive compounds using Raman spectroscopy and principal component analysis

    NASA Astrophysics Data System (ADS)

    Hwang, Joonki; Park, Aaron; Chung, Jin Hyuk; Choi, Namhyun; Park, Jun-Qyu; Cho, Soo Gyeong; Baek, Sung-June; Choo, Jaebum

    2013-06-01

    Recently, the development of methods for the identification of explosive materials that are faster, more sensitive, easier to use, and more cost-effective has become a very important issue for homeland security and counter-terrorism applications. However, limited applicability of several analytical methods such as, the incapability of detecting explosives in a sealed container, the limited portability of instruments, and false alarms due to the inherent lack of selectivity, have motivated the increased interest in the application of Raman spectroscopy for the rapid detection and identification of explosive materials. Raman spectroscopy has received a growing interest due to its stand-off capacity, which allows samples to be analyzed at distance from the instrument. In addition, Raman spectroscopy has the capability to detect explosives in sealed containers such as glass or plastic bottles. We report a rapid and sensitive recognition technique for explosive compounds using Raman spectroscopy and principal component analysis (PCA). Seven hundreds of Raman spectra (50 measurements per sample) for 14 selected explosives were collected, and were pretreated with noise suppression and baseline elimination methods. PCA, a well-known multivariate statistical method, was applied for the proper evaluation, feature extraction, and identification of measured spectra. Here, a broad wavenumber range (200- 3500 cm-1) on the collected spectra set was used for the classification of the explosive samples into separate classes. It was found that three principal components achieved 99.3 % classification rates in the sample set. The results show that Raman spectroscopy in combination with PCA is well suited for the identification and differentiation of explosives in the field.

  14. Pricing index-based catastrophe bonds: Part 2: Object-oriented design issues and sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Unger, André J. A.

    2010-02-01

    This work is the second installment in a two-part series, and focuses on object-oriented programming methods to implement an augmented-state variable approach to aggregate the PCS index and introduce the Bermudan-style call feature into the proposed CAT bond model. The PCS index is aggregated quarterly using a discrete Asian running-sum formulation. The resulting aggregate PCS index augmented-state variable is used to specify the payoff (principle) on the CAT bond based on reinsurance layers. The purpose of the Bermudan-style call option is to allow the reinsurer to minimize their interest rate risk exposure on making fixed coupon payments under prevailing interest rates. A sensitivity analysis is performed to determine the impact of uncertainty in the frequency and magnitude of hurricanes on the price of the CAT bond. Results indicate that while the CAT bond is highly sensitive to the natural variability in the frequency of landfalling hurricanes between El Ninõ and non-El Ninõ years, it remains relatively insensitive to uncertainty in the magnitude of damages. In addition, results indicate that the maximum price of the CAT bond is insensitive to whether it is engineered to cover low frequency high magnitude events in a 'high' reinsurance layer relative to high frequency low magnitude events in a 'low' reinsurance layer. Also, while it is possible for the reinsurer to minimize their interest rate risk exposure on the fixed coupon payments, the impact of this risk on the price of the CAT bond appears small relative to the natural variability in the CAT bond price, and consequently catastrophic risk, due to uncertainty in the frequency and magnitude of landfalling hurricanes.

  15. Sensitivity analysis and evaluation of microFacCO: a microscale motor vehicle emission factor model for CO emissions.

    PubMed

    Singh, R B; Huber, A H

    2001-07-01

    This paper presents a sensitivity analysis of a microscale emission factor model (MicroFacCO) for predicting real-time site-specific motor vehicle CO emissions to input variables, as well as a limited field study evaluation of the model. The sensitivity analysis has shown that MicroFacCO emission estimates are very sensitive to vehicle fleet composition, speed, and ambient temperature. For the present U.S. traffic fleet, the CO emission rate (g/mi) is increased by more than 500% at 5 mph in comparison with a speed greater than 40 mph and by approximately 67% at ambient temperatures of 45 degrees F and > or = 95 degrees F in comparison with an ambient temperature of 75 degrees F. The input variable "emission failure standard rate" is more sensitive to estimating emission rates in the 1990s than in the 2000s. The estimation of emission rates is not very sensitive to relative humidity. MicroFacCO can also be applied to examine the contribution of emission rates per vehicle class and model year. The model evaluation is presented for tunnel studies at five locations. In general, this evaluation study found good agreement between the measured and the modeled emissions. These analyses and evaluations have identified the need for additional studies to update the high-speed (>35 mph) air conditioning (A/C) correction factor and to add effects due to road grades. MicroFacCO emission estimates are very sensitive to the emission standard failure rate. Therefore, the model performance can be greatly improved by using a local emission standard failure rate. PMID:15658226

  16. Spatial sensitivity analysis of snow cover data in a distributed rainfall-runoff model

    NASA Astrophysics Data System (ADS)

    Berezowski, T.; Nossent, J.; Chormański, J.; Batelaan, O.

    2015-04-01

    As the availability of spatially distributed data sets for distributed rainfall-runoff modelling is strongly increasing, more attention should be paid to the influence of the quality of the data on the calibration. While a lot of progress has been made on using distributed data in simulations of hydrological models, sensitivity of spatial data with respect to model results is not well understood. In this paper we develop a spatial sensitivity analysis method for spatial input data (snow cover fraction - SCF) for a distributed rainfall-runoff model to investigate when the model is differently subjected to SCF uncertainty in different zones of the model. The analysis was focussed on the relation between the SCF sensitivity and the physical and spatial parameters and processes of a distributed rainfall-runoff model. The methodology is tested for the Biebrza River catchment, Poland, for which a distributed WetSpa model is set up to simulate 2 years of daily runoff. The sensitivity analysis uses the Latin-Hypercube One-factor-At-a-Time (LH-OAT) algorithm, which employs different response functions for each spatial parameter representing a 4 × 4 km snow zone. The results show that the spatial patterns of sensitivity can be easily interpreted by co-occurrence of different environmental factors such as geomorphology, soil texture, land use, precipitation and temperature. Moreover, the spatial pattern of sensitivity under different response functions is related to different spatial parameters and physical processes. The results clearly show that the LH-OAT algorithm is suitable for our spatial sensitivity analysis approach and that the SCF is spatially sensitive in the WetSpa model. The developed method can be easily applied to other models and other spatial data.

  17. Personalization of models with many model parameters: an efficient sensitivity analysis approach.

    PubMed

    Donders, W P; Huberts, W; van de Vosse, F N; Delhaas, T

    2015-10-01

    Uncertainty quantification and global sensitivity analysis are indispensable for patient-specific applications of models that enhance diagnosis or aid decision-making. Variance-based sensitivity analysis methods, which apportion each fraction of the output uncertainty (variance) to the effects of individual input parameters or their interactions, are considered the gold standard. The variance portions are called the Sobol sensitivity indices and can be estimated by a Monte Carlo (MC) approach (e.g., Saltelli's method [1]) or by employing a metamodel (e.g., the (generalized) polynomial chaos expansion (gPCE) [2, 3]). All these methods require a large number of model evaluations when estimating the Sobol sensitivity indices for models with many parameters [4]. To reduce the computational cost, we introduce a two-step approach. In the first step, a subset of important parameters is identified for each output of interest using the screening method of Morris [5]. In the second step, a quantitative variance-based sensitivity analysis is performed using gPCE. Efficient sampling strategies are introduced to minimize the number of model runs required to obtain the sensitivity indices for models considering multiple outputs. The approach is tested using a model that was developed for predicting post-operative flows after creation of a vascular access for renal failure patients. We compare the sensitivity indices obtained with the novel two-step approach with those obtained from a reference analysis that applies Saltelli's MC method. The two-step approach was found to yield accurate estimates of the sensitivity indices at two orders of magnitude lower computational cost. PMID:26017545

  18. A New Computationally Frugal Method For Sensitivity Analysis Of Environmental Models

    NASA Astrophysics Data System (ADS)

    Rakovec, O.; Hill, M. C.; Clark, M. P.; Weerts, A.; Teuling, R.; Borgonovo, E.; Uijlenhoet, R.

    2013-12-01

    Effective and efficient parameter sensitivity analysis methods are crucial to understand the behaviour of complex environmental models and use of models in risk assessment. This paper proposes a new computationally frugal method for analyzing parameter sensitivity: the Distributed Evaluation of Local Sensitivity Analysis (DELSA). The DELSA method can be considered a hybrid of local and global methods, and focuses explicitly on multiscale evaluation of parameter sensitivity across the parameter space. Results of the DELSA method are compared with the popular global, variance-based Sobol' method and the delta method. We assess the parameter sensitivity of both (1) a simple non-linear reservoir model with only two parameters, and (2) five different "bucket-style" hydrologic models applied to a medium-sized catchment (200 km2) in the Belgian Ardennes. Results show that in both the synthetic and real-world examples, the global Sobol' method and the DELSA method provide similar sensitivities, with the DELSA method providing more detailed insight at much lower computational cost. The ability to understand how sensitivity measures vary through parameter space with modest computational requirements provides exciting new opportunities.

  19. Sensitivity Analysis of Biome-Bgc Model for Dry Tropical Forests of Vindhyan Highlands, India

    NASA Astrophysics Data System (ADS)

    Kumar, M.; Raghubanshi, A. S.

    2011-08-01

    A process-based model BIOME-BGC was run for sensitivity analysis to see the effect of ecophysiological parameters on net primary production (NPP) of dry tropical forest of India. The sensitivity test reveals that the forest NPP was highly sensitive to the following ecophysiological parameters: Canopy light extinction coefficient (k), Canopy average specific leaf area (SLA), New stem C : New leaf C (SC:LC), Maximum stomatal conductance (gs,max), C:N of fine roots (C:Nfr), All-sided to projected leaf area ratio and Canopy water interception coefficient (Wint). Therefore, these parameters need more precision and attention during estimation and observation in the field studies.

  20. Value-Driven Design and Sensitivity Analysis of Hybrid Energy Systems using Surrogate Modeling

    SciTech Connect

    Wenbo Du; Humberto E. Garcia; William R. Binder; Christiaan J. J. Paredis

    2001-10-01

    A surrogate modeling and analysis methodology is applied to study dynamic hybrid energy systems (HES). The effect of battery size on the smoothing of variability in renewable energy generation is investigated. Global sensitivity indices calculated using surrogate models show the relative sensitivity of system variability to dynamic properties of key components. A value maximization approach is used to consider the tradeoff between system variability and required battery size. Results are found to be highly sensitive to the renewable power profile considered, demonstrating the importance of accurate renewable resource modeling and prediction. The documented computational framework and preliminary results represent an important step towards a comprehensive methodology for HES evaluation, design, and optimization.

  1. Changes of pore systems and infiltration analysis in two degraded soils after rock fragment addition

    NASA Astrophysics Data System (ADS)

    Gargiulo, Laura; Coppola, Antonio; De Mascellis, Roberto; Basile, Angelo; Mele, Giacomo; Terribile, Fabio

    2015-04-01

    Many soils in arid and semi-arid environments contain high amounts of rock fragments as a result of both natural soil forming processes and human activities. The amount, dimension and shape of rock fragment strongly influence soil structure development and therefore many soil processes (e.g. infiltration, water storage, solute transport, etc.). The aim of this work was to test the effects on both infiltration process and soil pore formation following an addition of rock fragments. The test was performed on two different soils: a clayey soil (Alfisol) and a clay loamy soil (Entisol) showing both a natural compact structure and water stagnation problems in field. Three concentrations of 4-8mm rock fragments (15%, 25% and 35%) were added to air-dried soils and the repacked samples have been subject to nine wet/dry cycles in order to induce soil structure formation and its stabilization. The process of infiltration was monitored at -12 cm of pressure heads imposed at the soil surface and kept constant for a certain time by a tension infiltrometer. Moreover, k(h) was determined imposing -9, -6,-3 and -1 cm at soil surface and applying a steady-state solution. After the hydrological measurements the soil samples were resin-impregnated and images of vertical sections of the samples, acquired at 20µm resolution, were analyzed in order to quantify the pore size distribution. This latter was calculated using the "successive opening" approach. The Entisol samples showed similar infiltration curves I(t) among the 4 treatments, with higher percentage of stones (i.e. 25 and 35%) showing a faster rising in the early-time (< 2 min) infiltration; the Alfisol samples are spread, showing a higher variability: limiting the analysis to the first three, despite they show a similar shape, the higher the stones content the lower the cumulated infiltration. The behavior of the 35% sample diverges from the others: it shows a fast rising step at the very early time (< 2 min) followed by a

  2. Methane flux in non-wetland soils in response to nitrogen addition: a meta-analysis.

    PubMed

    Aronson, E L; Helliker, B R

    2010-11-01

    The controls on methane (CH4) flux into and out of soils are not well understood. Environmental variables including temperature, precipitation, and nitrogen (N) status can have strong effects on the magnitude and direction (e.g., uptake vs. release) of CH4 flux. To better understand the interactions between CH4-cycling microorganisms and N in the non-wetland soil system, a meta-analysis was performed on published literature comparing CH4 flux in N amended and matched control plots. An appropriate study index was developed for this purpose. It was found that smaller amounts of N tended to stimulate CH4 uptake while larger amounts tended to inhibit uptake by the soil. When all other variables were accounted for, the switch occurred at 100 kg N x ha(-1) x yr(-1). Managed land and land with a longer duration of fertilization showed greater inhibition of CH4 uptake with added N. These results support the hypotheses that large amounts of available N can inhibit methanotrophy, but also that methanotrophs in upland soils can be N limited in their consumption of CH4 from the atmosphere. There were interactions between other variables and N addition on the CH4 flux response: lower temperature and, to a lesser extent, higher precipitation magnified the inhibition of CH4 uptake due to N addition. Several mechanisms that may cause these trends are discussed, but none could be conclusively supported with this approach. Further controlled and in situ study should be undertaken to isolate the correct mechanism(s) responsible and to model upland CH4 flux. PMID:21141185

  3. A comparative analysis of British and Taiwanese students' conceptual and procedural knowledge of fraction addition

    NASA Astrophysics Data System (ADS)

    Li, Hui-Chuan

    2014-10-01

    This study examines students' procedural and conceptual achievement in fraction addition in England and Taiwan. A total of 1209 participants (561 British students and 648 Taiwanese students) at ages 12 and 13 were recruited from England and Taiwan to take part in the study. A quantitative design by means of a self-designed written test is adopted as central to the methodological considerations. The test has two major parts: the concept part and the skill part. The former is concerned with students' conceptual knowledge of fraction addition and the latter is interested in students' procedural competence when adding fractions. There were statistically significant differences both in concept and skill parts between the British and Taiwanese groups with the latter having a higher score. The analysis of the students' responses to the skill section indicates that the superiority of Taiwanese students' procedural achievements over those of their British peers is because most of the former are able to apply algorithms to adding fractions far more successfully than the latter. Earlier, Hart [1] reported that around 30% of the British students in their study used an erroneous strategy (adding tops and bottoms, for example, 2/3 + 1/7 = 3/10) while adding fractions. This study also finds that nearly the same percentage of the British group remained using this erroneous strategy to add fractions as Hart found in 1981. The study also provides evidence to show that students' understanding of fractions is confused and incomplete, even those who are successfully able to perform operations. More research is needed to be done to help students make sense of the operations and eventually attain computational competence with meaningful grounding in the domain of fractions.

  4. In-cloud sulfate addition to single particles resolved with sulfur isotope analysis during HCCT-2010

    NASA Astrophysics Data System (ADS)

    Harris, E.; Sinha, B.; van Pinxteren, D.; Schneider, J.; Poulain, L.; Collett, J.; D'Anna, B.; Fahlbusch, B.; Foley, S.; Fomba, K. W.; George, C.; Gnauk, T.; Henning, S.; Lee, T.; Mertes, S.; Roth, A.; Stratmann, F.; Borrmann, S.; Hoppe, P.; Herrmann, H.

    2014-01-01

    In-cloud production of sulfate modifies the aerosol size distribution, with important implications for the magnitude of indirect and direct aerosol cooling and the impact of SO2 emissions on the environment. We investigate which sulfate sources dominate the in-cloud addition of sulfate to different particle classes as an air parcel passes through an orographic cloud. Sulfate aerosol, SO2 and H2SO4 were collected upwind, in-cloud and downwind of an orographic cloud for three cloud measurement events during the Hill Cap Cloud Thuringia campaign in Autumn, 2010 (HCCT-2010). Combined SEM and NanoSIMS analysis of single particles allowed the δ34S of particulate sulfate to be resolved for particle size and type. The most important in-cloud SO2 oxidation pathway at HCCT-2010 was aqueous oxidation catalysed by transition metal ions (TMI catalysis), which was shown with single particle isotope analyses to occur primarily in cloud droplets nucleated on coarse mineral dust. In contrast, direct uptake of H2SO4(g) and ultrafine particulate were the most important sources modifying fine mineral dust, increasing its hygroscopicity and facilitating activation. Sulfate addition to "mixed" particles (secondary organic and inorganic aerosol) and coated soot was dominated by in-cloud aqueous SO2 oxidation by H2O2 and direct uptake of H2SO4(g) and ultrafine particle sulfate, depending on particle size mode and time of day. These results provide new insight into in-cloud sulfate production mechanisms, and show the importance of single particle measurements and models to accurately assess the environmental effects of cloud processing.

  5. In-cloud sulfate addition to single particles resolved with sulfur isotope analysis during HCCT-2010

    NASA Astrophysics Data System (ADS)

    Harris, E.; Sinha, B.; van Pinxteren, D.; Schneider, J.; Poulain, L.; Collett, J.; D'Anna, B.; Fahlbusch, B.; Foley, S.; Fomba, K. W.; George, C.; Gnauk, T.; Henning, S.; Lee, T.; Mertes, S.; Roth, A.; Stratmann, F.; Borrmann, S.; Hoppe, P.; Herrmann, H.

    2014-04-01

    In-cloud production of sulfate modifies aerosol size distribution, with important implications for the magnitude of indirect and direct aerosol cooling and the impact of SO2 emissions on the environment. We investigate which sulfate sources dominate the in-cloud addition of sulfate to different particle classes as an air parcel passes through an orographic cloud. Sulfate aerosol, SO2 and H2SO4 were collected upwind, in-cloud and downwind of an orographic cloud for three cloud measurement events during the Hill Cap Cloud Thuringia campaign in autumn 2010 (HCCT-2010). Combined SEM and NanoSIMS analysis of single particles allowed the δ34S of particulate sulfate to be resolved for particle size and type. The most important in-cloud SO2 oxidation pathway at HCCT-2010 was aqueous oxidation catalysed by transition metal ions (TMI catalysis), which was shown with single particle isotope analyses to occur primarily in cloud droplets nucleated on coarse mineral dust. In contrast, direct uptake of H2SO4 (g) and ultrafine particulate were the most important sources modifying fine mineral dust, increasing its hygroscopicity and facilitating activation. Sulfate addition to "mixed" particles (secondary organic and inorganic aerosol) and coated soot was dominated by in-cloud aqueous SO2 oxidation by H2O2 and direct uptake of H2SO4 (g) and ultrafine particle sulfate, depending on particle size mode and time of day. These results provide new insight into in-cloud sulfate production mechanisms, and show the importance of single particle measurements and models to accurately assess the environmental effects of cloud processing.

  6. Analysis of Time to Event Outcomes in Randomized Controlled Trials by Generalized Additive Models

    PubMed Central

    Argyropoulos, Christos; Unruh, Mark L.

    2015-01-01

    Background Randomized Controlled Trials almost invariably utilize the hazard ratio calculated with a Cox proportional hazard model as a treatment efficacy measure. Despite the widespread adoption of HRs, these provide a limited understanding of the treatment effect and may even provide a biased estimate when the assumption of proportional hazards in the Cox model is not verified by the trial data. Additional treatment effect measures on the survival probability or the time scale may be used to supplement HRs but a framework for the simultaneous generation of these measures is lacking. Methods By splitting follow-up time at the nodes of a Gauss Lobatto numerical quadrature rule, techniques for Poisson Generalized Additive Models (PGAM) can be adopted for flexible hazard modeling. Straightforward simulation post-estimation transforms PGAM estimates for the log hazard into estimates of the survival function. These in turn were used to calculate relative and absolute risks or even differences in restricted mean survival time between treatment arms. We illustrate our approach with extensive simulations and in two trials: IPASS (in which the proportionality of hazards was violated) and HEMO a long duration study conducted under evolving standards of care on a heterogeneous patient population. Findings PGAM can generate estimates of the survival function and the hazard ratio that are essentially identical to those obtained by Kaplan Meier curve analysis and the Cox model. PGAMs can simultaneously provide multiple measures of treatment efficacy after a single data pass. Furthermore, supported unadjusted (overall treatment effect) but also subgroup and adjusted analyses, while incorporating multiple time scales and accounting for non-proportional hazards in survival data. Conclusions By augmenting the HR conventionally reported, PGAMs have the potential to support the inferential goals of multiple stakeholders involved in the evaluation and appraisal of clinical trial

  7. Experiences on p-Version Time-Discontinuous Galerkin's Method for Nonlinear Heat Transfer Analysis and Sensitivity Analysis

    NASA Technical Reports Server (NTRS)

    Hou, Gene

    2004-01-01

    The focus of this research is on the development of analysis and sensitivity analysis equations for nonlinear, transient heat transfer problems modeled by p-version, time discontinuous finite element approximation. The resulting matrix equation of the state equation is simply in the form ofA(x)x = c, representing a single step, time marching scheme. The Newton-Raphson's method is used to solve the nonlinear equation. Examples are first provided to demonstrate the accuracy characteristics of the resultant finite element approximation. A direct differentiation approach is then used to compute the thermal sensitivities of a nonlinear heat transfer problem. The report shows that only minimal coding effort is required to enhance the analysis code with the sensitivity analysis capability.

  8. Response sensitivity analysis of the dynamic milling process based on the numerical integration method

    NASA Astrophysics Data System (ADS)

    Ding, Ye; Zhu, Limin; Zhang, Xiaojian; Ding, Han

    2012-09-01

    As one of the bases of gradient-based optimization algorithms, sensitivity analysis is usually required to calculate the derivatives of the system response with respect to the machining parameters. The most widely used approaches for sensitivity analysis are based on time-consuming numerical methods, such as finite difference methods. This paper presents a semi-analytical method for calculation of the sensitivity of the stability boundary in milling. After transforming the delay-differential equation with time-periodic coefficients governing the dynamic milling process into the integral form, the Floquet transition matrix is constructed by using the numerical integration method. Then, the analytical expressions of derivatives of the Floquet transition matrix with respect to the machining parameters are obtained. Thereafter, the classical analytical expression of the sensitivity of matrix eigenvalues is employed to calculate the sensitivity of the stability lobe diagram. The two-degree-of-freedom milling example illustrates the accuracy and efficiency of the proposed method. Compared with the existing methods, the unique merit of the proposed method is that it can be used for analytically computing the sensitivity of the stability boundary in milling, without employing any finite difference methods. Therefore, the high accuracy and high efficiency are both achieved. The proposed method can serve as an effective tool for machining parameter optimization and uncertainty analysis in high-speed milling.

  9. Assessing parameter importance of the Common Land Model based on qualitative and quantitative sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Li, J.; Duan, Q. Y.; Gong, W.; Ye, A.; Dai, Y.; Miao, C.; Di, Z.; Tong, C.; Sun, Y.

    2013-08-01

    Proper specification of model parameters is critical to the performance of land surface models (LSMs). Due to high dimensionality and parameter interaction, estimating parameters of an LSM is a challenging task. Sensitivity analysis (SA) is a tool that can screen out the most influential parameters on model outputs. In this study, we conducted parameter screening for six output fluxes for the Common Land Model: sensible heat, latent heat, upward longwave radiation, net radiation, soil temperature and soil moisture. A total of 40 adjustable parameters were considered. Five qualitative SA methods, including local, sum-of-trees, multivariate adaptive regression splines, delta test and Morris methods, were compared. The proper sampling design and sufficient sample size necessary to effectively screen out the sensitive parameters were examined. We found that there are 2-8 sensitive parameters, depending on the output type, and about 400 samples are adequate to reliably identify the most sensitive parameters. We also employed a revised Sobol' sensitivity method to quantify the importance of all parameters. The total effects of the parameters were used to assess the contribution of each parameter to the total variances of the model outputs. The results confirmed that global SA methods can generally identify the most sensitive parameters effectively, while local SA methods result in type I errors (i.e., sensitive parameters labeled as insensitive) or type II errors (i.e., insensitive parameters labeled as sensitive). Finally, we evaluated and confirmed the screening results for their consistency with the physical interpretation of the model parameters.

  10. Assessing parameter importance of the Common Land Model based on qualitative and quantitative sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Li, J. D.; Duan, Q. Y.; Gong, W.; Ye, A. Z.; Dai, Y. J.; Miao, C. Y.; Di, Z. H.; Tong, C.; Sun, Y. W.

    2013-02-01

    Proper specification of model parameters is critical to the performance of land surface models (LSMs). Due to high dimensionality and parameter interaction, estimating parameters of a LSM is a challenging task. Sensitivity analysis (SA) is a tool that can screen out the most influential parameters on model outputs. In this study, we conducted parameter screening for six output fluxes for the Common Land Model: sensible heat, latent heat, upward longwave radiation, net radiation, soil temperature and soil moisture. A total of 40 adjustable parameters were considered. Five qualitative SA methods, including local, sum-of-trees, multivariate adaptive regression splines, delta test and Morris methods, were compared. The proper sampling design and sufficient sample size necessary to effectively screen out the sensitive parameters were examined. We found that there are 2-8 sensitive parameters, depending on the output type, and about 400 samples are adequate to reliably identify the most sensitive parameters. We also employed a revised Sobol' sensitivity method to quantify the importance of all parameters. The total effects of the parameters were used to assess the contribution of each parameter to the total variances of the model outputs. The results confirmed that global SA methods can generally identify the most sensitive parameters effectively, while local SA methods result in type I errors (i.e. sensitive parameters labeled as insensitive) or type II errors (i.e. insensitive parameters labeled as sensitive). Finally, we evaluated and confirmed the screening results for their consistence with the physical interpretation of the model parameters.

  11. Can Additional Homeopathic Treatment Save Costs? A Retrospective Cost-Analysis Based on 44500 Insured Persons

    PubMed Central

    Ostermann, Julia K.; Reinhold, Thomas; Witt, Claudia M.

    2015-01-01

    Objectives The aim of this study was to compare the health care costs for patients using additional homeopathic treatment (homeopathy group) with the costs for those receiving usual care (control group). Methods Cost data provided by a large German statutory health insurance company were retrospectively analysed from the societal perspective (primary outcome) and from the statutory health insurance perspective. Patients in both groups were matched using a propensity score matching procedure based on socio-demographic variables as well as costs, number of hospital stays and sick leave days in the previous 12 months. Total cumulative costs over 18 months were compared between the groups with an analysis of covariance (adjusted for baseline costs) across diagnoses and for six specific diagnoses (depression, migraine, allergic rhinitis, asthma, atopic dermatitis, and headache). Results Data from 44,550 patients (67.3% females) were available for analysis. From the societal perspective, total costs after 18 months were higher in the homeopathy group (adj. mean: EUR 7,207.72 [95% CI 7,001.14–7,414.29]) than in the control group (EUR 5,857.56 [5,650.98–6,064.13]; p<0.0001) with the largest differences between groups for productivity loss (homeopathy EUR 3,698.00 [3,586.48–3,809.53] vs. control EUR 3,092.84 [2,981.31–3,204.37]) and outpatient care costs (homeopathy EUR 1,088.25 [1,073.90–1,102.59] vs. control EUR 867.87 [853.52–882.21]). Group differences decreased over time. For all diagnoses, costs were higher in the homeopathy group than in the control group, although this difference was not always statistically significant. Conclusion Compared with usual care, additional homeopathic treatment was associated with significantly higher costs. These analyses did not confirm previously observed cost savings resulting from the use of homeopathy in the health care system. PMID:26230412

  12. Geometrically nonlinear design sensitivity analysis on parallel-vector high-performance computers

    NASA Technical Reports Server (NTRS)

    Baddourah, Majdi A.; Nguyen, Duc T.

    1993-01-01

    Parallel-vector solution strategies for generation and assembly of element matrices, solution of the resulted system of linear equations, calculations of the unbalanced loads, displacements, stresses, and design sensitivity analysis (DSA) are all incorporated into the Newton Raphson (NR) procedure for nonlinear finite element analysis and DSA. Numerical results are included to show the performance of the proposed method for structural analysis and DSA in a parallel-vector computer environment.

  13. Sensitivity analysis and identification of the best evapotranspiration and runoff options for hydrological modelling in SWAT-2000

    NASA Astrophysics Data System (ADS)

    Kannan, N.; White, S. M.; Worrall, F.; Whelan, M. J.

    2007-01-01

    SummaryDistributed models used in hydrological modelling, have many parameters. To get useful results from the model, every parameter is required to have a sensible value. Usually a calibration is undertaken to reduce the uncertainties associated with the estimation of model parameters. To ensure efficient calibration, a sensitivity analysis is conducted to identify the most sensitive parameters. This paper describes simple and efficient approaches for sensitivity analysis, calibration and identification of the best methodology within a modelling framework. For this study, the SWAT-2000 model was used on a small catchment of 141.5 ha in the Unilever Colworth estate, in Bedfordshire, England. Acceptable performance in hydrological modelling, and correct simulation of the processes driving the water balance were essential requirements for subsequent pesticide modelling. SWAT gives various options for both evapotranspiration and runoff modelling. Identification of the best modelling option for these processes is a pre-requisite to achieve these requirements. As a first step, a sensitivity analysis was conducted to identify the sensitive parameters affecting stream flow for subsequent application in stream flow calibration. Hydrological modelling has been carried out for the catchment for the period September 1999 to May 2002 inclusive using both daily and sub-daily rainfall data. The Hargreaves and Penman-Montieth methods of evapotranspiration estimation and the NRCS curve number (CN) and Green and Ampt infiltration methods for runoff estimation techniques were used, in four different combinations, to identify the combination of methodologies that best reproduced the observed data. In addition, as the initial calibration period, starting in September 1999, was substantially wetter than the following corresponding validation period, the calibration and validation periods are interchanged to test the impact of calibration using wet or dry periods.

  14. Application of design sensitivity analysis for greater improvement on machine structural dynamics

    NASA Technical Reports Server (NTRS)

    Yoshimura, Masataka

    1987-01-01

    Methodologies are presented for greatly improving machine structural dynamics by using design sensitivity analyses and evaluative parameters. First, design sensitivity coefficients and evaluative parameters of structural dynamics are described. Next, the relations between the design sensitivity coefficients and the evaluative parameters are clarified. Then, design improvement procedures of structural dynamics are proposed for the following three cases: (1) addition of elastic structural members, (2) addition of mass elements, and (3) substantial charges of joint design variables. Cases (1) and (2) correspond to the changes of the initial framework or configuration, and (3) corresponds to the alteration of poor initial design variables. Finally, numerical examples are given for demonstrating the availability of the methods proposed.

  15. Sensitivity and uncertainty analysis of reactivities for UO2 and MOX fueled PWR cells

    SciTech Connect

    Foad, Basma; Takeda, Toshikazu

    2015-12-31

    The purpose of this paper is to apply our improved method for calculating sensitivities and uncertainties of reactivity responses for UO{sub 2} and MOX fueled pressurized water reactor cells. The improved method has been used to calculate sensitivity coefficients relative to infinite dilution cross-sections, where the self-shielding effect is taken into account. Two types of reactivities are considered: Doppler reactivity and coolant void reactivity, for each type of reactivity, the sensitivities are calculated for small and large perturbations. The results have demonstrated that the reactivity responses have larger relative uncertainty than eigenvalue responses. In addition, the uncertainty of coolant void reactivity is much greater than Doppler reactivity especially for large perturbations. The sensitivity coefficients and uncertainties of both reactivities were verified by comparing with SCALE code results using ENDF/B-VII library and good agreements have been found.

  16. Sensitivity analysis

    MedlinePlus

    Smith MB, LaSala PR, Woods GL. In vitro testing of antimicrobial agents. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods . 22nd ed. Philadelphia, PA: Elsevier ...

  17. Design sensitivity analysis and optimization tool (DSO) for sizing design applications

    NASA Technical Reports Server (NTRS)

    Chang, Kuang-Hua; Choi, Kyung K.; Perng, Jyh-Hwa

    1992-01-01

    The DSO tool, a structural design software system that provides the designer with a graphics-based menu-driven design environment to perform easy design optimization for general applications, is presented. Three design stages, preprocessing, design sensitivity analysis, and postprocessing, are implemented in the DSO to allow the designer to carry out the design process systematically. A framework, including data base, user interface, foundation class, and remote module, has been designed and implemented to facilitate software development for the DSO. A number of dedicated commercial software/packages have been integrated in the DSO to support the design procedures. Instead of parameterizing an FEM, design parameters are defined on a geometric model associated with physical quantities, and the continuum design sensitivity analysis theory is implemented to compute design sensitivity coefficients using postprocessing data from the analysis codes. A tracked vehicle road wheel is given as a sizing design application to demonstrate the DSO's easy and convenient design optimization process.

  18. Methodology for sensitivity analysis, approximate analysis, and design optimization in CFD for multidisciplinary applications. [computational fluid dynamics

    NASA Technical Reports Server (NTRS)

    Taylor, Arthur C., III; Hou, Gene W.

    1992-01-01

    Fundamental equations of aerodynamic sensitivity analysis and approximate analysis for the two dimensional thin layer Navier-Stokes equations are reviewed, and special boundary condition considerations necessary to apply these equations to isolated lifting airfoils on 'C' and 'O' meshes are discussed in detail. An efficient strategy which is based on the finite element method and an elastic membrane representation of the computational domain is successfully tested, which circumvents the costly 'brute force' method of obtaining grid sensitivity derivatives, and is also useful in mesh regeneration. The issue of turbulence modeling is addressed in a preliminary study. Aerodynamic shape sensitivity derivatives are efficiently calculated, and their accuracy is validated on two viscous test problems, including: (1) internal flow through a double throat nozzle, and (2) external flow over a NACA 4-digit airfoil. An automated aerodynamic design optimization strategy is outlined which includes the use of a design optimization program, an aerodynamic flow analysis code, an aerodynamic sensitivity and approximate analysis code, and a mesh regeneration and grid sensitivity analysis code. Application of the optimization methodology to the two test problems in each case resulted in a new design having a significantly improved performance in the aerodynamic response of interest.

  19. Methodology for sensitivity analysis, approximate analysis, and design optimization in CFD for multidisciplinary applications

    NASA Technical Reports Server (NTRS)

    Taylor, Arthur C., III; Hou, Gene W.

    1993-01-01

    In this study involving advanced fluid flow codes, an incremental iterative formulation (also known as the delta or correction form) together with the well-known spatially-split approximate factorization algorithm, is presented for solving the very large sparse systems of linear equations which are associated with aerodynamic sensitivity analysis. For smaller 2D problems, a direct method can be applied to solve these linear equations in either the standard or the incremental form, in which case the two are equivalent. Iterative methods are needed for larger 2D and future 3D applications, however, because direct methods require much more computer memory than is currently available. Iterative methods for solving these equations in the standard form are generally unsatisfactory due to an ill-conditioning of the coefficient matrix; this problem can be overcome when these equations are cast in the incremental form. These and other benefits are discussed. The methodology is successfully implemented and tested in 2D using an upwind, cell-centered, finite volume formulation applied to the thin-layer Navier-Stokes equations. Results are presented for two sample airfoil problems: (1) subsonic low Reynolds number laminar flow; and (2) transonic high Reynolds number turbulent flow.

  20. Retrospective analysis of radial EBUS outcome for the diagnosis of peripheral pulmonary lesion: sensitivity and complications

    PubMed Central

    Durakovic, Amal; Andersen, Henrik; Christiansen, Anders; Hammen, Irena

    2015-01-01

    Background The purpose of the current study was to clarify the sensitivity and complication rate of the radial (endobronchial ultrasound, EBUS) without the use of guide-sheath (GS) and fluoroscopy for lung cancer (LC), by measuring the distance from the orifice of the bronchus to the pulmonary lesion, as well as to analyze factors that can predict the diagnostic outcome. Materials and methods A total of 147 patients with peripheral pulmonary lesions (PPL) underwent radial EBUS-guided transbronchial biopsy (TBB) in between August 1, 2013, and August 31, 2014. We analyzed retrospectively radiological data, diagnostic work-up in everyday clinical settings, final diagnosis and complication rates, as well as factors influencing the diagnostic outcome. Results Around 63.9% of PPLs were visualized by ultrasound. A definitive malignant diagnosis was established in 39 patients (26.5%) using radial EBUS. In the remaining 108 patients, additional procedures were performed. We missed LC diagnosis in 40 cases that results in a sensitivity of 49%. For malignant lesions visualized by radial EBUS, the sensitivity was 60%, compared with 24% for not visualized lesions. For malignant lesions, logistic regression was performed to identify the factors that had significant influence on visualization of the lesion and on diagnostic yield. Logistic regression analysis showed significant odds ratios (OR) for visualization depending on location of the lesion; upper lobe lesions were identified more frequent with OR of 3.85 (95% CI 1.42 – 10.98, p=0.009). Size above 30 mm had a non-significant OR of 2.11 (95% CI 0.80−5.73, p=0.134) for visualization. Diagnostic yield was only significantly influenced by visualization with the radial EBUS, OR 3.70 (95% CI 1.35−11.02, p=0.014). Location (p=0.745) and size above 30 mm (p=0.308) showed no significant increase in diagnostic yield. Other lesion characteristics defined on computed tomography, such as distance to carina and pleura, did not