#### Sample records for additional independent variables

1. Independent, dependent, and other variables in healthcare and chaplaincy research.

PubMed

Flannelly, Laura T; Flannelly, Kevin J; Jankowski, Katherine R B

2014-01-01

This article begins by defining the term variable and the terms independent variable and dependent variable, providing examples of each. It then proceeds to describe and discuss synonyms for the terms independent variable and dependent variable, including treatment, intervention, predictor, and risk factor, and synonyms for dependent variable, such as response variables and outcomes. The article explains that the terms extraneous, nuisance, and confounding variables refer to any variable that can interfere with the ability to establish relationships between independent variables and dependent variables, and it describes ways to control for such confounds. It further explains that even though intervening, mediating, and moderating variables explicitly alter the relationship between independent variables and dependent variables, they help to explain the causal relationship between them. In addition, the article links terminology about variables with the concept of levels of measurement in research.

2. Problems Identifying Independent and Dependent Variables

ERIC Educational Resources Information Center

Leatham, Keith R.

2012-01-01

This paper discusses one step from the scientific method--that of identifying independent and dependent variables--from both scientific and mathematical perspectives. It begins by analyzing an episode from a middle school mathematics classroom that illustrates the need for students and teachers alike to develop a robust understanding of…

3. Understanding graphs with two independent variables

NASA Astrophysics Data System (ADS)

Cooper, Jennifer L.

4. Depression and Pain: Independent and Additive Relationships to Anger Expression

DTIC Science & Technology

2013-10-01

Naval Health Research Center Depression and Pain : Independent and Additive Relationships to Anger Expression Marcus K. Taylor Gerald E...AND SUBTITLE Depression and Pain : Independent and Additive Relationships to Anger Expression 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...expression are understudied. OBJECTIVE: This study was designed to examine the independent and additive relationships of depression and pain to anger

5. Ridge Regression: A Regression Procedure for Analyzing correlated Independent Variables

ERIC Educational Resources Information Center

Rakow, Ernest A.

1978-01-01

Ridge regression is a technique used to ameliorate the problem of highly correlated independent variables in multiple regression analysis. This paper explains the fundamentals of ridge regression and illustrates its use. (JKS)

6. Computer optimization program finds values for several independent variables that minimize a dependent variable

NASA Technical Reports Server (NTRS)

Warech, E. J.

1967-01-01

Computer program finds values of independent variables which minimize the dependent variable. This optimization program has been used on the F-1 and J-2 engine programs to establish minimum film coolant requirements.

7. Iterative Strain-Gage Balance Calibration Data Analysis for Extended Independent Variable Sets

NASA Technical Reports Server (NTRS)

Ulbrich, Norbert Manfred

2011-01-01

A new method was developed that makes it possible to use an extended set of independent calibration variables for an iterative analysis of wind tunnel strain gage balance calibration data. The new method permits the application of the iterative analysis method whenever the total number of balance loads and other independent calibration variables is greater than the total number of measured strain gage outputs. Iteration equations used by the iterative analysis method have the limitation that the number of independent and dependent variables must match. The new method circumvents this limitation. It simply adds a missing dependent variable to the original data set by using an additional independent variable also as an additional dependent variable. Then, the desired solution of the regression analysis problem can be obtained that fits each gage output as a function of both the original and additional independent calibration variables. The final regression coefficients can be converted to data reduction matrix coefficients because the missing dependent variables were added to the data set without changing the regression analysis result for each gage output. Therefore, the new method still supports the application of the two load iteration equation choices that the iterative method traditionally uses for the prediction of balance loads during a wind tunnel test. An example is discussed in the paper that illustrates the application of the new method to a realistic simulation of temperature dependent calibration data set of a six component balance.

8. Additional security features for optically variable foils

NASA Astrophysics Data System (ADS)

Marshall, Allan C.; Russo, Frank

1998-04-01

For thousands of years, man has exploited the attraction and radiance of pure gold to adorn articles of great significance. Today, designers decorate packaging with metallic gold foils to maintain the prestige of luxury items such as perfumes, chocolates, wine and whisky, and to add visible appeal and value to wide range of products. However, today's products do not call for the hand beaten gold leaf of the Ancient Egyptians, instead a rapid production technology exists which makes use of accurately coated thin polymer films and vacuum deposited metallic layers. Stamping Foils Technology is highly versatile since several different layers may be combined into one product, each providing a different function. Not only can a foil bring visual appeal to an article, it can provide physical and chemical resistance properties and also protect an article from human forms of interference, such as counterfeiting, copying or tampering. Stamping foils have proved to be a highly effective vehicle for applying optical devices to items requiring this type of protection. Credit cards, bank notes, personal identification documents and more recently high value packaged items such as software and perfumes are protected by optically variable devices applied using stamping foil technology.

9. Cardiac output and venous return as interdependent and independent variables.

PubMed

1981-01-01

Under steady states the heart pumps whatever it receives and receives whatever it pumps. In other words, cardiac output (CO) and venous return (VR) are equal and the distinction between the two seems unnecessary. However, under nonsteady states the two are temporarily unequal and the distinction becomes significant. VR varies directly with the difference in pressure between the end of systemic capillaries and the right ventricle during filling and inversely with the total resistance of the venous system. Thus, the energy for VR is derived from CO. In some transient states VR becomes an independent variable and CO dependent until a new steady state is reached (e.g., exercise, hemorrhage, fevers, hyperthyroidism, severe anemia, etc.). In other conditions the opposite is true (e.g., myocardial infarction, altered ventricular contractility, etc.). Explanation of changes in cardiac output in various perturbations of circulation are based on the identification of the independent variable (VR or CO) in a given physiologic or pathologic condition during the period that a nonsteady state exists.

10. Variable and Asymmetric Range of Enslaving: Fingers Can Act Independently over Small Range of Flexion

PubMed Central

van den Noort, Josien C.; van Beek, Nathalie; van der Kraan, Thomas; Veeger, DirkJan H. E. J.; Stegeman, Dick F.; Veltink, Peter H.; Maas, Huub

2016-01-01

The variability in the numerous tasks in which we use our hands is very large. However, independent movement control of individual fingers is limited. To assess the extent of finger independency during full-range finger flexion including all finger joints, we studied enslaving (movement in non-instructed fingers) and range of independent finger movement through the whole finger flexion trajectory in single and multi-finger movement tasks. Thirteen young healthy subjects performed single- and multi-finger movement tasks under two conditions: active flexion through the full range of movement with all fingers free to move and active flexion while the non-instructed finger(s) were restrained. Finger kinematics were measured using inertial sensors (PowerGlove), to assess enslaving and range of independent finger movement. Although all fingers showed enslaving movement to some extent, highest enslaving was found in adjacent fingers. Enslaving effects in ring and little finger were increased with movement of additional, non-adjacent fingers. The middle finger was the only finger affected by restriction in movement of non-instructed fingers. Each finger showed a range of independent movement before the non-instructed fingers started to move, which was largest for the index finger. The start of enslaving was asymmetrical for adjacent fingers. Little finger enslaving movement was affected by multi-finger movement. We conclude that no finger can move independently through the full range of finger flexion, although some degree of full independence is present for smaller movements. This range of independent movement is asymmetric and variable between fingers and between subjects. The presented results provide insight into the role of finger independency for different types of tasks and populations. PMID:27992598

11. A provisional effective evaluation when errors are present in independent variables

NASA Technical Reports Server (NTRS)

Gurin, L. S.

1983-01-01

Algorithms are examined for evaluating the parameters of a regression model when there are errors in the independent variables. The algorithms are fast and the estimates they yield are stable with respect to the correlation of errors and measurements of both the dependent variable and the independent variables.

12. Decreasing Cloudiness Over China: An Updated Analysis Examining Additional Variables

SciTech Connect

Kaiser, D.P.

2000-01-14

As preparation of the IPCC's Third Assessment Report takes place, one of the many observed climate variables of key interest is cloud amount. For several nations of the world, there exist records of surface-observed cloud amount dating back to the middle of the 20th Century or earlier, offering valuable information on variations and trends. Studies using such databases include Sun and Groisman (1999) and Kaiser and Razuvaev (1995) for the former Soviet Union, Angel1 et al. (1984) for the United States, Henderson-Sellers (1986) for Europe, Jones and Henderson-Sellers (1992) for Australia, and Kaiser (1998) for China. The findings of Kaiser (1998) differ from the other studies in that much of China appears to have experienced decreased cloudiness over recent decades (1954-1994), whereas the other land regions for the most part show evidence of increasing cloud cover. This paper expands on Kaiser (1998) by analyzing trends in additional meteorological variables for Chi na [station pressure (p), water vapor pressure (e), and relative humidity (rh)] and extending the total cloud amount (N) analysis an additional two years (through 1996).

13. Regression mixture models: Does modeling the covariance between independent variables and latent classes improve the results?

PubMed Central

Lamont, Andrea E.; Vermunt, Jeroen K.; Van Horn, M. Lee

2016-01-01

Regression mixture models are increasingly used as an exploratory approach to identify heterogeneity in the effects of a predictor on an outcome. In this simulation study, we test the effects of violating an implicit assumption often made in these models – i.e., independent variables in the model are not directly related to latent classes. Results indicated that the major risk of failing to model the relationship between predictor and latent class was an increase in the probability of selecting additional latent classes and biased class proportions. Additionally, this study tests whether regression mixture models can detect a piecewise relationship between a predictor and outcome. Results suggest that these models are able to detect piecewise relations, but only when the relationship between the latent class and the predictor is included in model estimation. We illustrate the implications of making this assumption through a re-analysis of applied data examining heterogeneity in the effects of family resources on academic achievement. We compare previous results (which assumed no relation between independent variables and latent class) to the model where this assumption is lifted. Implications and analytic suggestions for conducting regression mixture based on these findings are noted. PMID:26881956

14. Regression Mixture Models: Does Modeling the Covariance Between Independent Variables and Latent Classes Improve the Results?

PubMed

Lamont, Andrea E; Vermunt, Jeroen K; Van Horn, M Lee

2016-01-01

Regression mixture models are increasingly used as an exploratory approach to identify heterogeneity in the effects of a predictor on an outcome. In this simulation study, we tested the effects of violating an implicit assumption often made in these models; that is, independent variables in the model are not directly related to latent classes. Results indicate that the major risk of failing to model the relationship between predictor and latent class was an increase in the probability of selecting additional latent classes and biased class proportions. In addition, we tested whether regression mixture models can detect a piecewise relationship between a predictor and outcome. Results suggest that these models are able to detect piecewise relations but only when the relationship between the latent class and the predictor is included in model estimation. We illustrate the implications of making this assumption through a reanalysis of applied data examining heterogeneity in the effects of family resources on academic achievement. We compare previous results (which assumed no relation between independent variables and latent class) to the model where this assumption is lifted. Implications and analytic suggestions for conducting regression mixture based on these findings are noted.

15. 10 CFR 431.174 - Additional requirements applicable to Voluntary Independent Certification Program participants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Additional requirements applicable to Voluntary Independent Certification Program participants. 431.174 Section 431.174 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Provisions...

16. 10 CFR 431.175 - Additional requirements applicable to non-Voluntary Independent Certification Program participants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... represented value of energy usage is no less than the greater of the mean of the sample, or the upper 95... 10 Energy 3 2011-01-01 2011-01-01 false Additional requirements applicable to non-Voluntary Independent Certification Program participants. 431.175 Section 431.175 Energy DEPARTMENT OF ENERGY...

17. A Spline-Based Lack-Of-Fit Test for Independent Variable Effect in Poisson Regression.

PubMed

Li, Chin-Shang; Tu, Wanzhu

2007-05-01

In regression analysis of count data, independent variables are often modeled by their linear effects under the assumption of log-linearity. In reality, the validity of such an assumption is rarely tested, and its use is at times unjustifiable. A lack-of-fit test is proposed for the adequacy of a postulated functional form of an independent variable within the framework of semiparametric Poisson regression models based on penalized splines. It offers added flexibility in accommodating the potentially non-loglinear effect of the independent variable. A likelihood ratio test is constructed for the adequacy of the postulated parametric form, for example log-linearity, of the independent variable effect. Simulations indicate that the proposed model performs well, and misspecified parametric model has much reduced power. An example is given.

18. Multiple correlation computer program determines relationships between several independent and dependent variables

NASA Technical Reports Server (NTRS)

Kaspar, H.; Newsbaum, J. B.

1967-01-01

Relationships between independent and dependent variables are determined by multiple correlation computer program. This is applied to research and experimental design and development of complex hardware and components that require test programs.

19. Concentration Addition, Independent Action and Generalized Concentration Addition Models for Mixture Effect Prediction of Sex Hormone Synthesis In Vitro

PubMed Central

Hadrup, Niels; Taxvig, Camilla; Pedersen, Mikael; Nellemann, Christine; Hass, Ulla; Vinggaard, Anne Marie

2013-01-01

Humans are concomitantly exposed to numerous chemicals. An infinite number of combinations and doses thereof can be imagined. For toxicological risk assessment the mathematical prediction of mixture effects, using knowledge on single chemicals, is therefore desirable. We investigated pros and cons of the concentration addition (CA), independent action (IA) and generalized concentration addition (GCA) models. First we measured effects of single chemicals and mixtures thereof on steroid synthesis in H295R cells. Then single chemical data were applied to the models; predictions of mixture effects were calculated and compared to the experimental mixture data. Mixture 1 contained environmental chemicals adjusted in ratio according to human exposure levels. Mixture 2 was a potency adjusted mixture containing five pesticides. Prediction of testosterone effects coincided with the experimental Mixture 1 data. In contrast, antagonism was observed for effects of Mixture 2 on this hormone. The mixtures contained chemicals exerting only limited maximal effects. This hampered prediction by the CA and IA models, whereas the GCA model could be used to predict a full dose response curve. Regarding effects on progesterone and estradiol, some chemicals were having stimulatory effects whereas others had inhibitory effects. The three models were not applicable in this situation and no predictions could be performed. Finally, the expected contributions of single chemicals to the mixture effects were calculated. Prochloraz was the predominant but not sole driver of the mixtures, suggesting that one chemical alone was not responsible for the mixture effects. In conclusion, the GCA model seemed to be superior to the CA and IA models for the prediction of testosterone effects. A situation with chemicals exerting opposing effects, for which the models could not be applied, was identified. In addition, the data indicate that in non-potency adjusted mixtures the effects cannot always be

20. The Variable Transition State in Polar Additions to Pi Bonds

ERIC Educational Resources Information Center

Weiss, Hilton M.

2010-01-01

A vast majority of polar additions of Bronsted acids to alkynes involve a termolecular transition state. With strong acids, considerable positive charge is developed on carbon and Markovnikov addition predominates. In less acidic solutions, however, the reaction is much slower and the transition state more closely resembles the olefinic product.…

1. The Effects of Problem Format, Number of Independent Variables, and Their Interaction on Student Performance on a Control of Variables Reasoning Problem.

ERIC Educational Resources Information Center

Staver, John R.

1986-01-01

Reviews an investigation of the effects of problem format and the number of independent variables on the responses of students to a control of variables reasoning task. Results indicate that adding independent variables to a control of variables reasoning problem leads to an overload of working memory which affects performance. (ML)

2. Independent variable complexity for regional regression of the flow duration curve in ungauged basins

NASA Astrophysics Data System (ADS)

Fouad, Geoffrey; Skupin, André; Hope, Allen

2016-04-01

The flow duration curve (FDC) is one of the most widely used tools to quantify streamflow. Its percentile flows are often required for water resource applications, but these values must be predicted for ungauged basins with insufficient or no streamflow data. Regional regression is a commonly used approach for predicting percentile flows that involves identifying hydrologic regions and calibrating regression models to each region. The independent variables used to describe the physiographic and climatic setting of the basins are a critical component of regional regression, yet few studies have investigated their effect on resulting predictions. In this study, the complexity of the independent variables needed for regional regression is investigated. Different levels of variable complexity are applied for a regional regression consisting of 918 basins in the US. Both the hydrologic regions and regression models are determined according to the different sets of variables, and the accuracy of resulting predictions is assessed. The different sets of variables include (1) a simple set of three variables strongly tied to the FDC (mean annual precipitation, potential evapotranspiration, and baseflow index), (2) a traditional set of variables describing the average physiographic and climatic conditions of the basins, and (3) a more complex set of variables extending the traditional variables to include statistics describing the distribution of physiographic data and temporal components of climatic data. The latter set of variables is not typically used in regional regression, and is evaluated for its potential to predict percentile flows. The simplest set of only three variables performed similarly to the other more complex sets of variables. Traditional variables used to describe climate, topography, and soil offered little more to the predictions, and the experimental set of variables describing the distribution of basin data in more detail did not improve predictions

3. Sequential Experimentation: Comparing Stochastic Approximation Methods Which Find the "Right" Value of the Independent Variable.

ERIC Educational Resources Information Center

Hummel, Thomas J.; Johnston, Charles B.

This research investigates stochastic approximation procedures of the Robbins-Monro type. Following a brief introduction to sequential experimentation, attention is focused on formal methods for selecting successive values of a single independent variable. Empirical results obtained through computer simulation are used to compare several formal…

4. Recommendations for Reporting Independent Variables in Outcome Studies of Early and Intensive Behavioral Intervention for Autism

ERIC Educational Resources Information Center

Lechago, Sarah A.; Carr, James E.

2008-01-01

Early and intensive behavioral intervention (EIBI) has been established as an effective treatment for autism. However, the complexity and intensity of EIBI programs make it difficult to fully report all critical aspects of the independent variable. Consequently, scientific reports of EIBI outcomes have been criticized for providing less than…

5. Independent and additive effects of glutamic acid and methionine on yeast longevity.

PubMed

Wu, Ziyun; Song, Lixia; Liu, Shao Quan; Huang, Dejian

2013-01-01

It is established that glucose restriction extends yeast chronological and replicative lifespan, but little is known about the influence of amino acids on yeast lifespan, although some amino acids were reported to delay aging in rodents. Here we show that amino acid composition greatly alters yeast chronological lifespan. We found that non-essential amino acids (to yeast) methionine and glutamic acid had the most significant impact on yeast chronological lifespan extension, restriction of methionine and/or increase of glutamic acid led to longevity that was not the result of low acetic acid production and acidification in aging media. Remarkably, low methionine, high glutamic acid and glucose restriction additively and independently extended yeast lifespan, which could not be further extended by buffering the medium (pH 6.0). Our preliminary findings using yeasts with gene deletion demonstrate that glutamic acid addition, methionine and glucose restriction prompt yeast longevity through distinct mechanisms. This study may help to fill a gap in yeast model for the fast developing view that nutrient balance is a critical factor to extend lifespan.

6. Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity

PubMed Central

Wu, Ziyun; Song, Lixia; Liu, Shao Quan; Huang, Dejian

2013-01-01

It is established that glucose restriction extends yeast chronological and replicative lifespan, but little is known about the influence of amino acids on yeast lifespan, although some amino acids were reported to delay aging in rodents. Here we show that amino acid composition greatly alters yeast chronological lifespan. We found that non-essential amino acids (to yeast) methionine and glutamic acid had the most significant impact on yeast chronological lifespan extension, restriction of methionine and/or increase of glutamic acid led to longevity that was not the result of low acetic acid production and acidification in aging media. Remarkably, low methionine, high glutamic acid and glucose restriction additively and independently extended yeast lifespan, which could not be further extended by buffering the medium (pH 6.0). Our preliminary findings using yeasts with gene deletion demonstrate that glutamic acid addition, methionine and glucose restriction prompt yeast longevity through distinct mechanisms. This study may help to fill a gap in yeast model for the fast developing view that nutrient balance is a critical factor to extend lifespan. PMID:24244480

7. Datafish Multiphase Data Mining Technique to Match Multiple Mutually Inclusive Independent Variables in Large PACS Databases.

PubMed

Kelley, Brendan P; Klochko, Chad; Halabi, Safwan; Siegal, Daniel

2016-06-01

Retrospective data mining has tremendous potential in research but is time and labor intensive. Current data mining software contains many advanced search features but is limited in its ability to identify patients who meet multiple complex independent search criteria. Simple keyword and Boolean search techniques are ineffective when more complex searches are required, or when a search for multiple mutually inclusive variables becomes important. This is particularly true when trying to identify patients with a set of specific radiologic findings or proximity in time across multiple different imaging modalities. Another challenge that arises in retrospective data mining is that much variation still exists in how image findings are described in radiology reports. We present an algorithmic approach to solve this problem and describe a specific use case scenario in which we applied our technique to a real-world data set in order to identify patients who matched several independent variables in our institution's picture archiving and communication systems (PACS) database.

8. The Use of Additional GPS Frequencies to Independently Determine Tropospheric Water Vapor Profiles

NASA Technical Reports Server (NTRS)

Herman, B.M.; Feng, D.; Flittner, D. E.; Kursinski, E. R.

2000-01-01

It is well known that the currently employed L1 and L2 GPS/MET frequencies (1.2 - 1.6) Ghz) do not allow for the separation of water vapor and density (or temperature) from active microwave occultation measurements in regions of the troposphere warmer than 240 K Therefore, additional information must be used, from other types of measurements and weather analyses, to recover water vapor (and temperature) profiles. Thus in data sparse regions, these inferred profiles can be subject to larger errors than would result in data rich regions. The use of properly selected additional GPS frequencies enables a direct, independent measurement of the absorption associated with the water vapor profile, which may then be used in the standard GPS/MET retrievals to obtain a more accurate determination of atmospheric temperature throughout the water vapor layer. This study looks at the use of microwave crosslinks in the region of the 22 Ghz water vapor absorption line for this purpose. An added advantage of using 22 Ghz frequencies is that they are only negligibly affected by the ionosphere in contrast to the large effect at the GPS frequencies. The retrieval algorithm uses both amplitude and phase measurements to obtain profiles of atmospheric pressure, temperature and water water vapor pressure with a vertical resolution of 1 km or better. This technique also provides the cloud liquid water content along the ray path, which is in itself an important element in climate monitoring. Advantages of this method include the ability to make measurements in the presence of clouds and the use of techniques and technology proven through the GPS/MET experiment and several of NASA's planetary exploration missions. Simulations demonstrating this method will be presented for both clear and cloudy sky conditions.

9. Estimation of blood pressure variability using independent component analysis of photoplethysmographic signal.

PubMed

Abe, Makoto; Yoshizawa, Makoto; Sugita, Norihiro; Tanaka, Akira; Chiba, Shigeru; Yambe, Tomoyuki; Nitta, Shin-ichi

2009-01-01

The maximum cross-correlation coefficient rho(max) between blood pressure variability and heart rate variability, whose frequency components are limited to the Mayer wave-related band, is a useful index to evaluate the state of the autonomic nervous function related to baroreflex. However, measurement of continuous blood pressure with an expensive and bulky measuring device is required to calculate rho(max). The present study has proposed an easier method for obtaining rho(max) with measurement of finger photoplethysmography (PPG). In the proposed method, independent components are extracted from feature variables specified by the PPG signal by using the independent component analysis (ICA), and then the most appropriate component is chosen out of them so that the rho(max) based on the component can fit its true value. The results from the experiment with a postural change performed in 17 healthy subjects suggested that the proposed method is available for estimating rho(max) by using the ICA to extract blood pressure information from the PPG signal.

10. Recommendations for reporting independent variables in outcome studies of early and intensive behavioral intervention for autism.

PubMed

Lechago, Sarah A; Carr, James E

2008-07-01

Early and intensive behavioral intervention (EIBI) has been established as an effective treatment for autism. However, the complexity and intensity of EIBI programs make it difficult to fully report all critical aspects of the independent variable. Consequently, scientific reports of EIBI outcomes have been criticized for providing less than comprehensive treatment descriptions. In an effort to address this problem, the present article provides a template to aid outcome researchers in (a) clearly reporting each participant's curricular targets and (b) describing critical aspects of treatment.

11. Independent component analysis of local-scale temporal variability in sediment-water interface temperature

NASA Astrophysics Data System (ADS)

Middleton, M. A.; Whitfield, P. H.; Allen, D. M.

2015-12-01

Temperature recorded at the sediment-water interface has been identified as a valuable tracer for understanding groundwater-surface water interactions. However, factors contributing to the variability in temperatures can be difficult to distinguish. In this study, the temporal variability in daily temperatures at the sediment-water interface is evaluated for a 40 m reach of a coastal stream using Independent Component Analysis (ICA). ICA separation is used to identify three independent temperature components within the reach for each of four summer periods (2008-2011). Extracted temperature signals correlate with stream discharge, estimated streambed temperature, and groundwater level, but the strength of the correlations varies from summer to summer. Overall, variations in the temperature signals have clearer separation in summers with lower stream discharge and greater stream temperature ranges. Surface heating from solar radiation is the dominant factor influencing the sediment-water interface temperature in most years, but there is evidence that thermal exchanges are taking place other than at the air-water interface. These exchanges take place at the sediment-water interface, and the correlation with groundwater levels indicates that these heat exchanges are associated with groundwater inflow. This study demonstrates that ICA can be used effectively to aid in identifying component signals in environmental applications of small spatial scale.

12. Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

PubMed Central

Plümpe, Tobias; Ehninger, Dan; Steiner, Barbara; Klempin, Friederike; Jessberger, Sebastian; Brandt, Moritz; Römer, Benedikt; Rodriguez, Gerardo Ramirez; Kronenberg, Golo; Kempermann, Gerd

2006-01-01

Background In the course of adult hippocampal neurogenesis most regulation takes place during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on precursor cells or as survival-promoting effect on postmitotic cells. We here obtained quantitative data about the proliferative population and the dynamics of postmitotic dendrite development during the period of DCX expression. The question was, whether any indication could be obtained that the initiation of dendrite development is timely bound to the exit from the cell cycle. Alternatively, the temporal course of morphological maturation might be subject to additional regulatory events. Results We found that (1) 20% of the DCX population were precursor cells in cell cycle, whereas more than 70% were postmitotic, (2) the time span until newborn cells had reached the most mature stage associated with DCX expression varied between 3 days and several weeks, (3) positive or negative regulation of precursor cell proliferation did not alter the pattern and dynamics of dendrite development. Dendrite maturation was largely independent of close contacts to astrocytes. Conclusion These data imply that dendrite maturation of immature neurons is initiated at varying times after cell cycle exit, is variable in duration, and is controlled independently of the regulation of precursor cell proliferation. We conclude that in addition to the major regulatory events in cell proliferation and selective survival, additional micro-regulatory events influence the course of adult hippocampal neurogenesis. PMID:17105671

13. Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis

PubMed Central

Wei, Wen-Hua; Bowes, John; Plant, Darren; Viatte, Sebastien; Yarwood, Annie; Massey, Jonathan; Worthington, Jane; Eyre, Stephen

2016-01-01

Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a two-stage approach to make vGWAS applicable to diseases: firstly using a mixed model approach to partition dichotomous phenotypes into additive risk and non-additive environmental residuals on the liability scale and secondly using the Levene’s (Brown-Forsythe) test to assess equality of the residual variances across genotype groups per marker. We found widespread significant (P < 2.5e-05) vGWAS signals within the major histocompatibility complex (MHC) across all three study cohorts of rheumatoid arthritis. We further identified 10 epistatic interactions between the vGWAS signals independent of the MHC additive effects, each with a weak effect but jointly explained 1.9% of phenotypic variance. PTPN22 was also identified in the discovery cohort but replicated in only one independent cohort. Combining the three cohorts boosted power of vGWAS and additionally identified TYK2 and ANKRD55. Both PTPN22 and TYK2 had evidence of interactions reported elsewhere. We conclude that vGWAS can help discover interacting loci for complex diseases but require large samples to find additional signals. PMID:27109064

14. Nitrogen addition and warming independently influence the belowground micro-food web in a temperate steppe.

PubMed

Li, Qi; Bai, Huahua; Liang, Wenju; Xia, Jianyang; Wan, Shiqiang; van der Putten, Wim H

2013-01-01

Climate warming and atmospheric nitrogen (N) deposition are known to influence ecosystem structure and functioning. However, our understanding of the interactive effect of these global changes on ecosystem functioning is relatively limited, especially when it concerns the responses of soils and soil organisms. We conducted a field experiment to study the interactive effects of warming and N addition on soil food web. The experiment was established in 2006 in a temperate steppe in northern China. After three to four years (2009-2010), we found that N addition positively affected microbial biomass and negatively influenced trophic group and ecological indices of soil nematodes. However, the warming effects were less obvious, only fungal PLFA showed a decreasing trend under warming. Interestingly, the influence of N addition did not depend on warming. Structural equation modeling analysis suggested that the direct pathway between N addition and soil food web components were more important than the indirect connections through alterations in soil abiotic characters or plant growth. Nitrogen enrichment also affected the soil nematode community indirectly through changes in soil pH and PLFA. We conclude that experimental warming influenced soil food web components of the temperate steppe less than N addition, and there was little influence of warming on N addition effects under these experimental conditions.

15. Nitrogen Addition and Warming Independently Influence the Belowground Micro-Food Web in a Temperate Steppe

PubMed Central

Li, Qi; Bai, Huahua; Liang, Wenju; Xia, Jianyang; Wan, Shiqiang; van der Putten, Wim H.

2013-01-01

Climate warming and atmospheric nitrogen (N) deposition are known to influence ecosystem structure and functioning. However, our understanding of the interactive effect of these global changes on ecosystem functioning is relatively limited, especially when it concerns the responses of soils and soil organisms. We conducted a field experiment to study the interactive effects of warming and N addition on soil food web. The experiment was established in 2006 in a temperate steppe in northern China. After three to four years (2009–2010), we found that N addition positively affected microbial biomass and negatively influenced trophic group and ecological indices of soil nematodes. However, the warming effects were less obvious, only fungal PLFA showed a decreasing trend under warming. Interestingly, the influence of N addition did not depend on warming. Structural equation modeling analysis suggested that the direct pathway between N addition and soil food web components were more important than the indirect connections through alterations in soil abiotic characters or plant growth. Nitrogen enrichment also affected the soil nematode community indirectly through changes in soil pH and PLFA. We conclude that experimental warming influenced soil food web components of the temperate steppe less than N addition, and there was little influence of warming on N addition effects under these experimental conditions. PMID:23544140

16. Increased rainfall variability and N addition accelerate litter decomposition in a restored prairie.

PubMed

Schuster, Michael J

2016-03-01

Anthropogenic nitrogen deposition and projected increases in rainfall variability (the frequency of drought and heavy rainfall events) are expected to strongly influence ecosystem processes such as litter decomposition. However, how these two global change factors interact to influence litter decomposition is largely unknown. I examined how increased rainfall variability and nitrogen addition affected mass and nitrogen loss of litter from two tallgrass prairie species, Schizachyrium scoparium and Solidago canadensis, and isolated the effects of each during plant growth and during litter decomposition. I increased rainfall variability by consolidating ambient rainfall into larger events and simulated chronic nitrogen deposition using a slow-release urea fertilizer. S. scoparium litter decay was more strongly regulated by the treatments applied during plant growth than by those applied during decomposition. During plant growth, increased rainfall variability resulted in S. scoparium litter that subsequently decomposed more slowly and immobilized more nitrogen than litter grown under ambient conditions, whereas nitrogen addition during plant growth accelerated subsequent mass loss of S. scoparium litter. In contrast, S. canadensis litter mass and N losses were enhanced under either N addition or increased rainfall variability both during plant growth and during decomposition. These results suggest that ongoing changes in rainfall variability and nitrogen availability are accelerating nutrient cycling in tallgrass prairies through their combined effects on litter quality, environmental conditions, and plant community composition.

17. Continuous-Variable Measurement-Device-Independent Multipartite Quantum Communication Using Coherent States

NASA Astrophysics Data System (ADS)

Zhou, Jian; Guo, Ying

2017-02-01

A continuous-variable measurement-device-independent (CV-MDI) multipartite quantum communication protocol is designed to realize multipartite communication based on the GHZ state analysis using Gaussian coherent states. It can remove detector side attack as the multi-mode measurement is blindly done in a suitable Black Box. The entanglement-based CV-MDI multipartite communication scheme and the equivalent prepare-and-measurement scheme are proposed to analyze the security and guide experiment, respectively. The general eavesdropping and coherent attack are considered for the security analysis. Subsequently, all the attacks are ascribed to coherent attack against imperfect links. The asymptotic key rate of the asymmetric configuration is also derived with the numeric simulations illustrating the performance of the proposed protocol.

18. Developing Independent Listening Skills for English as an Additional Language Students

ERIC Educational Resources Information Center

Picard, Michelle; Velautham, Lalitha

2016-01-01

This paper describes an action research project to develop online, self-access listening resources mirroring the authentic academic contexts experienced by graduate university students. Current listening materials for English as an Additional Language (EAL) students mainly use Standard American English or Standard British pronunciation, and far…

19. The development of the Poincare-similar elements with true anomaly as the independent variable

NASA Technical Reports Server (NTRS)

Mueller, A.

1976-01-01

In reference 1, the Hamiltonian of the unperturbed two-body problem in extended phase space is established. Depending on the type of time transformation, eight canonical elements were developed with the true anomaly or the eccentric anomaly as the independent variable. These two new sets, DS(phi) and DS(u), however contain singularities for small eccentricities and inclinations. In reference 2, these singularities are removed by a transformation from DS(u) to eight canonical PS(u) elements. In reference 3, the DS(phi) variables are transformed to the PS(phi) elements to remove the singularities. However, no direct relation was established between the eight canonical PS(phi) elements and the Cartesian coordinates. It is the purpose of this report to establish those relations and to develop the perturbed equations of motion in the PS(phi) space. This report also demonstrates the accuracy of this new set when it is applied to numerical orbit prediction problems.

20. Discrete and continuous variables for measurement-device-independent quantum cryptography

DOE PAGES

Xu, Feihu; Curty, Marcos; Qi, Bing; ...

2015-11-16

In a recent Article in Nature Photonics, Pirandola et al.1 claim that the achievable secret key rates of discrete-variable (DV) measurementdevice- independent (MDI) quantum key distribution (QKD) (refs 2,3) are “typically very low, unsuitable for the demands of a metropolitan network” and introduce a continuous-variable (CV) MDI QKD protocol capable of providing key rates which, they claim, are “three orders of magnitude higher” than those of DV MDI QKD. We believe, however, that the claims regarding low key rates of DV MDI QKD made by Pirandola et al.1 are too pessimistic. Here in this paper, we show that the secretmore » key rate of DV MDI QKD with commercially available high-efficiency single-photon detectors (SPDs) (for example, see http://www.photonspot.com/detectors and http://www.singlequantum.com) and good system alignment is typically rather high and thus highly suitable for not only long-distance communication but also metropolitan networks.« less

1. Discrete and continuous variables for measurement-device-independent quantum cryptography

SciTech Connect

Xu, Feihu; Curty, Marcos; Qi, Bing; Qian, Li; Lo, Hoi-Kwong

2015-11-16

In a recent Article in Nature Photonics, Pirandola et al.1 claim that the achievable secret key rates of discrete-variable (DV) measurementdevice- independent (MDI) quantum key distribution (QKD) (refs 2,3) are “typically very low, unsuitable for the demands of a metropolitan network” and introduce a continuous-variable (CV) MDI QKD protocol capable of providing key rates which, they claim, are “three orders of magnitude higher” than those of DV MDI QKD. We believe, however, that the claims regarding low key rates of DV MDI QKD made by Pirandola et al.1 are too pessimistic. Here in this paper, we show that the secret key rate of DV MDI QKD with commercially available high-efficiency single-photon detectors (SPDs) (for example, see http://www.photonspot.com/detectors and http://www.singlequantum.com) and good system alignment is typically rather high and thus highly suitable for not only long-distance communication but also metropolitan networks.

NASA Technical Reports Server (NTRS)

Smalheer, C. V.

1973-01-01

The chemistry of lubricant additives is discussed to show what the additives are chemically and what functions they perform in the lubrication of various kinds of equipment. Current theories regarding the mode of action of lubricant additives are presented. The additive groups discussed include the following: (1) detergents and dispersants, (2) corrosion inhibitors, (3) antioxidants, (4) viscosity index improvers, (5) pour point depressants, and (6) antifouling agents.

3. Additional role of O-acetylserine as a sulfur status-independent regulator during plant growth.

PubMed

Hubberten, Hans-Michael; Klie, Sebastian; Caldana, Camila; Degenkolbe, Thomas; Willmitzer, Lothar; Hoefgen, Rainer

2012-05-01

O-acetylserine (OAS) is one of the most prominent metabolites whose levels are altered upon sulfur starvation. However, its putative role as a signaling molecule in higher plants is controversial. This paper provides further evidence that OAS is a signaling molecule, based on computational analysis of time-series experiments and on studies of transgenic plants conditionally displaying increased OAS levels. Transcripts whose levels correlated with the transient and specific increase in OAS levels observed in leaves of Arabidopsis thaliana plants 5-10 min after transfer to darkness and with diurnal oscillation of the OAS content, showing a characteristic peak during the night, were identified. Induction of a serine-O-acetyltransferase gene (SERAT) in transgenic A. thaliana plants expressing the genes under the control of an inducible promoter resulted in a specific time-dependent increase in OAS levels. Monitoring the transcriptome response at time points at which no changes in sulfur-related metabolites except OAS were observed and correlating this with the light/dark transition and diurnal experiments resulted in identification of six genes whose expression was highly correlated with that of OAS (adenosine-5'-phosphosulfate reductase 3, sulfur-deficiency-induced 1, sulfur-deficiency-induced 2, low-sulfur-induced 1, serine hydroxymethyltransferase 7 and ChaC-like protein). These data suggest that OAS displays a signalling function leading to changes in transcript levels of a specific gene set irrespective of the sulfur status of the plant. Additionally, a role for OAS in a specific part of the sulfate response can be deduced.

4. Stochasticity and determinism: how density-independent and density-dependent processes affect population variability.

PubMed

Ohlberger, Jan; Rogers, Lauren A; Stenseth, Nils Chr

2014-01-01

A persistent debate in population ecology concerns the relative importance of environmental stochasticity and density dependence in determining variability in adult year-class strength, which contributes to future reproduction as well as potential yield in exploited populations. Apart from the strength of the processes, the timing of density regulation may affect how stochastic variation, for instance through climate, translates into changes in adult abundance. In this study, we develop a life-cycle model for the population dynamics of a large marine fish population, Northeast Arctic cod, to disentangle the effects of density-independent and density-dependent processes on early life-stages, and to quantify the strength of compensatory density dependence in the population. The model incorporates information from scientific surveys and commercial harvest, and dynamically links multiple effects of intrinsic and extrinsic factors on all life-stages, from eggs to spawners. Using a state-space approach we account for observation error and stochasticity in the population dynamics. Our findings highlight the importance of density-dependent survival in juveniles, indicating that this period of the life cycle largely determines the compensatory capacity of the population. Density regulation at the juvenile life-stage dampens the impact of stochastic processes operating earlier in life such as environmental impacts on the production of eggs and climate-dependent survival of larvae. The timing of stochastic versus regulatory processes thus plays a crucial role in determining variability in adult abundance. Quantifying the contribution of environmental stochasticity and compensatory mechanisms in determining population abundance is essential for assessing population responses to climate change and exploitation by humans.

5. A fuzzy adaptive network approach to parameter estimation in cases where independent variables come from an exponential distribution

NASA Astrophysics Data System (ADS)

Dalkilic, Turkan Erbay; Apaydin, Aysen

2009-11-01

In a regression analysis, it is assumed that the observations come from a single class in a data cluster and the simple functional relationship between the dependent and independent variables can be expressed using the general model; Y=f(X)+[epsilon]. However; a data cluster may consist of a combination of observations that have different distributions that are derived from different clusters. When faced with issues of estimating a regression model for fuzzy inputs that have been derived from different distributions, this regression model has been termed the [`]switching regression model' and it is expressed with . Here li indicates the class number of each independent variable and p is indicative of the number of independent variables [J.R. Jang, ANFIS: Adaptive-network-based fuzzy inference system, IEEE Transaction on Systems, Man and Cybernetics 23 (3) (1993) 665-685; M. Michel, Fuzzy clustering and switching regression models using ambiguity and distance rejects, Fuzzy Sets and Systems 122 (2001) 363-399; E.Q. Richard, A new approach to estimating switching regressions, Journal of the American Statistical Association 67 (338) (1972) 306-310]. In this study, adaptive networks have been used to construct a model that has been formed by gathering obtained models. There are methods that suggest the class numbers of independent variables heuristically. Alternatively, in defining the optimal class number of independent variables, the use of suggested validity criterion for fuzzy clustering has been aimed. In the case that independent variables have an exponential distribution, an algorithm has been suggested for defining the unknown parameter of the switching regression model and for obtaining the estimated values after obtaining an optimal membership function, which is suitable for exponential distribution.

6. Confirmation of mass-independent Ni isotopic variability in iron meteorites

NASA Astrophysics Data System (ADS)

Steele, Robert C. J.; Elliott, Tim; Coath, Christopher D.; Regelous, Marcel

2011-12-01

We report high-precision analyses of internally-normalised Ni isotope ratios in 12 bulk iron meteorites. Our measurements of 60Ni/ 61Ni, 62Ni/ 61Ni and 64Ni/ 61Ni normalised to 58Ni/ 61Ni and expressed in parts per ten thousand (‱) relative to NIST SRM 986 as ɛ60Ni,ɛ62Ni and ɛ64Ni, vary by 0.146, 0.228 and 0.687, respectively. The precision on a typical analysis is 0.03‱, 0.05‱ and 0.08‱ for ɛ60Ni, ɛ62Ni and ɛ64Ni, respectively, which is comparable to our sample reproducibility. We show that this 'mass-independent' Ni isotope variability cannot be ascribed to interferences, inaccurate correction of instrumental or natural mass-dependent fractionation, fractionation controlled by nuclear field shift effects, nor the influence of cosmic ray spallation. These results thus document the presence of mass-independent Ni isotopic heterogeneity in bulk meteoritic samples, as previously proposed by Regelous et al. (2008) (EPSL 272, 330-338), but our new analyses are more precise and include determination of 64Ni. Intriguingly, we find that terrestrial materials do not yield homogenous internally-normalised Ni isotope compositions, which, as pointed out by Young et al. (2002) (GCA 66, 1095-1104), may be the expected result of using the exponential (kinetic) law and atomic masses to normalise all fractionation processes. The certified Ni isotope reference material NIST SRM 986 defines zero in this study, while appropriate ratios for the bulk silicate Earth are given by the peridotites JP-1 and DTS-2 and, relative to NIST SRM 986, yield deviations in ɛ60Ni, ɛ62Ni and ɛ64Ni of -0.006‱, 0.036‱ and 0.119‱, respectively. There is a strong positive correlation between ɛ64Ni and ɛ62Ni in iron meteorites analyses, with a slope of 3.03 ± 0.71. The variations of Ni isotope anomalies in iron meteorites are consistent with heterogeneous distribution of a nucleosynthetic component from a type Ia supernova into the proto-solar nebula.

7. A Note on the Calculation and Interpretation of the Delta-p Statistic for Categorical Independent Variables

ERIC Educational Resources Information Center

Cruce, Ty M.

2009-01-01

This methodological note illustrates how a commonly used calculation of the Delta-p statistic is inappropriate for categorical independent variables, and this note provides users of logistic regression with a revised calculation of the Delta-p statistic that is more meaningful when studying the differences in the predicted probability of an…

8. The Relationship of Field Dependent/Independent Cognitive Styles, Stimuli Variability and Time Factor on Student Achievement.

ERIC Educational Resources Information Center

Atang, Christopher I.

The effects of black and white and color illustrations on student achievement were studied to investigate the relationships between cognitive styles and instructional design. Field dependence (FD) and field independence (FI) were chosen as the cognitive style variables. Subjects were 85 freshman students in the Iowa State University Psychology…

9. Pre-dialysis systolic blood pressure-variability is independently associated with all-cause mortality in incident haemodialysis patients.

PubMed

Selvarajah, Viknesh; Pasea, Laura; Ojha, Sanjay; Wilkinson, Ian B; Tomlinson, Laurie A

2014-01-01

Systolic blood pressure variability is an independent risk factor for mortality and cardiovascular events. Standard measures of blood pressure predict outcome poorly in haemodialysis patients. We investigated whether systolic blood pressure variability was associated with mortality in incident haemodialysis patients. We performed a longitudinal observational study of patients commencing haemodialysis between 2005 and 2011 in East Anglia, UK, excluding patients with cardiovascular events within 6 months of starting haemodialysis. The main exposure was variability independent of the mean (VIM) of systolic blood pressure from short-gap, pre-dialysis blood pressure readings between 3 and 6 months after commencing haemodialysis, and the outcome was all-cause mortality. Of 203 patients, 37 (18.2%) patients died during a mean follow-up of 2.0 (SD 1.3) years. The age and sex-adjusted hazard ratio (HR) for mortality was 1.09 (95% confidence interval (CI) 1.02-1.17) for a one-unit increase of VIM. This was not altered by adjustment for diabetes, prior cardiovascular disease and mean systolic blood pressure (HR 1.09, 95% CI 1.02-1.16). Patients with VIM of systolic blood pressure above the median were 2.4 (95% CI 1.17-4.74) times more likely to die during follow-up than those below the median. Results were similar for all measures of blood pressure variability and further adjustment for type of dialysis access, use of antihypertensives and absolute or variability of fluid intake did not alter these findings. Diastolic blood pressure variability showed no association with all cause mortality. Our study shows that variability of systolic blood pressure is a strong and independent predictor of all-cause mortality in incident haemodialysis patients. Further research is needed to understand the mechanism as this may form a therapeutic target or focus for management.

10. Structure of the isotropic transport operators in three independent space variables

NASA Technical Reports Server (NTRS)

Abu-Shumays, I. K.; Bareiss, E. H.

1969-01-01

Based on the idea of separation of variables, a spectral theory for the three-dimensional, stationary, isotropic transport operator in a vector space of complex-valued Borel functions results in continuous sets of regular and generalized eigenfunctions.

11. Achromatic recirculated chicane with fixed geometry and independently variable path length and momentum compaction

DOEpatents

Douglas, David R.; Neil, George R.

2005-04-26

A particle beam recirculated chicane geometry that, through the inducement of a pair of 180 degree bends directed by the poles of a pair of controllable magnetic fields allows for variation of dipole position, return loop radii and steering/focussing, thereby allowing the implementation of independent variation of path length and momentum compaction.

12. Field Dependence-Independence as a Variable in Second Language Cloze Test Performance.

ERIC Educational Resources Information Center

Stansfield, Charles; Hansen, Jacqueline

1983-01-01

A study of test performance and field dependent-independent (FD/I) cognitive style in 250 college students showed consistently positive correlation between FI and cloze test scores, and other measures such as final grade. It is suggested cloze tests may call forth cognitive restructuring capabilities more easily for more field independent…

13. Use of generalised additive models to categorise continuous variables in clinical prediction

PubMed Central

2013-01-01

Background In medical practice many, essentially continuous, clinical parameters tend to be categorised by physicians for ease of decision-making. Indeed, categorisation is a common practice both in medical research and in the development of clinical prediction rules, particularly where the ensuing models are to be applied in daily clinical practice to support clinicians in the decision-making process. Since the number of categories into which a continuous predictor must be categorised depends partly on the relationship between the predictor and the outcome, the need for more than two categories must be borne in mind. Methods We propose a categorisation methodology for clinical-prediction models, using Generalised Additive Models (GAMs) with P-spline smoothers to determine the relationship between the continuous predictor and the outcome. The proposed method consists of creating at least one average-risk category along with high- and low-risk categories based on the GAM smooth function. We applied this methodology to a prospective cohort of patients with exacerbated chronic obstructive pulmonary disease. The predictors selected were respiratory rate and partial pressure of carbon dioxide in the blood (PCO2), and the response variable was poor evolution. An additive logistic regression model was used to show the relationship between the covariates and the dichotomous response variable. The proposed categorisation was compared to the continuous predictor as the best option, using the AIC and AUC evaluation parameters. The sample was divided into a derivation (60%) and validation (40%) samples. The first was used to obtain the cut points while the second was used to validate the proposed methodology. Results The three-category proposal for the respiratory rate was ≤ 20;(20,24];> 24, for which the following values were obtained: AIC=314.5 and AUC=0.638. The respective values for the continuous predictor were AIC=317.1 and AUC=0.634, with no statistically

14. Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: evidence for independent additive controllers.

PubMed

Hogarth, Lee

2012-07-01

According to contemporary learning theory, drug-seeking behavior reflects the summation of 2 dissociable controllers. Whereas goal-directed drug-seeking is determined by the expected current incentive value of the drug, stimulus-elicited drug-seeking is determined by the expected probability of the drug independently of its current incentive value, and these 2 controllers contribute additively to observed drug-seeking. One applied prediction of this model is that smoking cessation pharmacotherapies selectively attenuate tonic but not cue-elicited craving because they downgrade the expected incentive value of the drug but leave expected probability intact. To test this, the current study examined whether nicotine replacement therapy (NRT) nasal spray would modify goal-directed tobacco choice in a human outcome devaluation procedure, but leave cue-elicited tobacco choice in a Pavlovian to instrumental transfer (PIT) procedure intact. Smokers (N= 96) first underwent concurrent choice training in which 2 responses earned tobacco or chocolate points, respectively. Participants then ingested either NRT nasal spray (1 mg) or chocolate (147 g) to devalue 1 outcome. Concurrent choice was then tested again in extinction to measure goal-directed control of choice, and in a PIT test to measure the extent to which tobacco and chocolate stimuli enhanced choice of the same outcome. It was found that NRT modified tobacco choice in the extinction test but not the extent to which the tobacco stimulus enhanced choice of the tobacco outcome in the PIT test. This dissociation suggests that the propensity to engage in drug-seeking is determined independently by the expected value and probability of the drug, and that pharmacotherapy has partial efficacy because it selectively effects expected drug value.

15. Validity of Taylor's Dissipation-Viscosity Independence Postulate in Variable-Viscosity Turbulent Fluid Mixtures

NASA Astrophysics Data System (ADS)

Lee, Kurnchul; Girimaji, Sharath S.; Kerimo, Johannes

2008-08-01

G. I. Taylor’s postulate [Proc. R. Soc. APRLAAZ0080-4630 151, 421 (1935)10.1098/rspa.1935.0158] that dissipation is independent of viscosity at high Reynolds numbers is the foundation of many single-fluid turbulence theories and closure models. The validity of this key postulate in an important class of flows, turbulent mixtures, is not yet clearly established. We devise a simple numerical experiment of decaying turbulence in a mixture of two fluids of vastly different viscosities to examine dissipation scaling. Initially, the two fluids are segregated, and dissipation is directly proportional to viscosity. As turbulence evolves and fluids mix, the velocity gradients rapidly adapt to the viscosity field, and within one-half eddy turnover time, dissipation-viscosity independence is established. Viscosity-weighted velocity-gradient skewness is shown to be constant, leading to the validity of Taylor’s postulate in turbulent mixtures.

16. Combined effects of independent variables on yield and protein content of pectin extracted from sugar beet pulp by citric acid.

PubMed

Li, De-Qiang; Du, Guang-Ming; Jing, Wei-Wen; Li, Jun-Fang; Yan, Jia-Yu; Liu, Zhi-Yong

2015-09-20

The extraction of pectin from sugar beet pulp by citric acid was carried out under different conditions using Box-Behnken design for four independent variables (pH, temperature, time and liquid to solid ratio). The yield of sugar beet pulp pectin ranged from 6.3% to 23.0%, and the content of protein from 1.5% to 4.5%. All independent variables significantly affected the yield, and all variables except liquid to solid ratio significantly affected the protein content. The yield increased as decreasing pH of extracting solution, extending time and advancing temperature, and an opposite relationship of effects between variables and content of protein was obtained. The chemical composition of collected samples was determined. Moreover, from the results of emulsifying properties study, the extracted pectin from sugar beet pulp could prepare steady oil-in-water emulsions. Therefore, it was inferred that the extraction conditions could influence yield and protein content, resulting in different emulsifying property.

17. Integrating Cost as an Independent Variable Analysis with Evolutionary Acquisition - A Multiattribute Design Evaluation Approach

DTIC Science & Technology

2003-03-01

within the Automated Cost Estimating Integrated Tools ( ACEIT ) software suite (version 5.x). With this capability, one can set cost targets or time...not allow the user to vary more than one decision variable. This limitation of the ACEIT approach thus hinders a holistic view when attempting to

18. Performance Variability, Impulsivity Errors and the Impact of Incentives as Gender-Independent Endophenotypes for ADHD

ERIC Educational Resources Information Center

Uebel, Henrik; Albrecht, Bjorn; Asherson, Philip; Borger, Norbert A.; Butler, Louise; Chen, Wai; Christiansen, Hanna; Heise, Alexander; Kuntsi, Jonna; Schafer, Ulrike; Andreou, Penny; Manor, Iris; Marco, Rafaela; Miranda, Ana; Mulligan, Aisling; Oades, Robert D.; van der Meere, Jaap; Faraone, Stephen V.; Rothenberger, Aribert; Banaschewski, Tobias

2010-01-01

Background: Attention-deficit hyperactivity disorder (ADHD) is one of the most common and highly heritable child psychiatric disorders. There is strong evidence that children with ADHD show slower and more variable responses in tasks such as Go/Nogo tapping aspects of executive functions like sustained attention and response control which may be…

19. Additional Navigational Strategies Can Augment Odor-Gated Rheotaxis for Navigation under Conditions of Variable Flow.

PubMed

Vasey, Gabrielle; Lukeman, Ryan; Wyeth, Russell C

2015-09-01

The navigation strategies animals use to find sources of odor depend on the olfactory stimuli, the properties of flowing fluids, and the locomotory capabilities of the animal. In high Reynolds number environments, animals typically use odor-gated rheotaxis to find the source of turbulent odor plumes. This strategy succeeds because, although turbulence creates an intermittent chemical cue, the animal follows the (continuous) directional cue created by the flow that is transporting the chemical. However, in nature, animals may lose all contact with an odor plume as variations in the direction of bulk flow cause the plume to be rotated away before the animal reaches the source of the odor. Our goal was to use a mathematical model to test the hypothesis that strategies that augment odor-gated rheotaxis would be beneficial for finding the source of an odor plume in such variable flow. The model links a stochastic variable-direction odor plume with a turbulence-based intermittent chemical signal and four different movement strategies, including: odor-gated rheotaxis alone (as a control), odor-gated rheotaxis augmented by further rheotaxis in the absence of odor, odor-gated rheotaxis augmented by a random walk, and odor-gated rheotaxis augmented by movement actively guided by the heading of the flow when the odor was still present. We found that any of the three augmented strategies could improve on strict odor-gated rheotaxis. Moreover, variations in performance caused the best strategy to depend on the speed of movement of the animal and the magnitude of the variation in flow, and more subtly on the duration over which the augmented strategy was performed. For most combinations of parameters in the model, either augmenting with a random walk or following the last-known heading were the best-performing strategies. Overall, our results suggest that marine animals that rely on odor cues to navigate in turbulent environments may augment odor-gated rheotaxis with additional

20. Neurons within the same network independently achieve conserved output by differentially balancing variable conductance magnitudes.

PubMed

Ransdell, Joseph L; Nair, Satish S; Schulz, David J

2013-06-12

Biological and theoretical evidence suggest that individual neurons may achieve similar outputs by differentially balancing variable underlying ionic conductances. Despite the substantial amount of data consistent with this idea, a direct biological demonstration that cells with conserved output, particularly within the same network, achieve these outputs via different solutions has been difficult to achieve. Here we demonstrate definitively that neurons from native neural networks with highly similar output achieve this conserved output by differentially tuning underlying conductance magnitudes. Multiple motor neurons of the crab (Cancer borealis) cardiac ganglion have highly conserved output within a preparation, despite showing a 2-4-fold range of conductance magnitudes. By blocking subsets of these currents, we demonstrate that the remaining conductances become unbalanced, causing disparate output as a result. Therefore, as strategies to understand neuronal excitability become increasingly sophisticated, it is important that such variability in excitability of neurons, even among those within the same individual, is taken into account.

1. Spatio-temporal variability of droughts and terrestrial water storage over Lake Chad Basin using independent component analysis

NASA Astrophysics Data System (ADS)

Ndehedehe, Christopher E.; Agutu, Nathan O.; Okwuashi, Onuwa; Ferreira, Vagner G.

2016-09-01

Lake Chad has recently been perceived to be completely desiccated and almost extinct due to insufficient published ground observations. Given the high spatial variability of rainfall in the region, and the fact that extreme climatic conditions (for example, droughts) could be intensifying in the Lake Chad basin (LCB) due to human activities, a spatio-temporal approach to drought analysis becomes essential. This study employed independent component analysis (ICA), a fourth-order cumulant statistics, to decompose standardised precipitation index (SPI), standardised soil moisture index (SSI), and terrestrial water storage (TWS) derived from Gravity Recovery and Climate Experiment (GRACE) into spatial and temporal patterns over the LCB. In addition, this study uses satellite altimetry data to estimate variations in the Lake Chad water levels, and further employs relevant climate teleconnection indices (El-Niño Southern Oscillation-ENSO, Atlantic Multi-decadal Oscillation-AMO, and Atlantic Meridional Mode-AMM) to examine their links to the observed drought temporal patterns over the basin. From the spatio-temporal drought analysis, temporal evolutions of SPI at 12 month aggregation show relatively wet conditions in the last two decades (although with marked alterations) with the 2012-2014 period being the wettest. In addition to the improved rainfall conditions during this period, there was a statistically significant increase of 0.04 m/yr in altimetry water levels observed over Lake Chad between 2008 and 2014, which confirms a shift in the hydrological conditions of the basin. Observed trend in TWS changes during the 2002-2014 period shows a statistically insignificant increase of 3.0 mm/yr at the centre of the basin, coinciding with soil moisture deficit indicated by the temporal evolutions of SSI at all monthly accumulations during the 2002-2003 and 2009-2012 periods. Further, SPI at 3 and 6 month scales indicated fluctuating drought conditions at the extreme south

2. Month of birth as an independent variable in the sudden infant death syndrome.

PubMed

Douglas, A S; Gupta, R; Helms, P J; Jolliffe, I T

1997-01-01

Well-known epidemiological features of sudden infant death syndrome (SIDS) are age at death and the increased numbers in winter. There are more SIDS deaths in late autumn/early winter and there is a seasonal rhythm of births with a peak in late summer and early autumn. The data set was 14033 SIDS deaths from Scotland, England and Wales over the 11 years 1982-92. Using log-linear models, which accounted for age at death and month of death, birth month was found to be a statistically significant risk factor for SIDS independent of age at death and winter environment (P < 0.001). Although winter season had the largest effect (relative risk 2.7 in January compared with August), the independent effect of birth month was of clinical as well as statistical significance with a relative risk for August births of 1.37 compared with those born in April. The analysis of each birth month cohort revealed a change in age distribution with infants born in early winter (December) dying at a younger age (mean 108 days) than those born in midsummer (June) (mean 146 days). Although winter season and age are the most influential factors, the substantial effect of month of birth requires explanation and points to as yet unidentified environmental influences during pregnancy.

3. Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks.

PubMed

Gehring, Tobias; Händchen, Vitus; Duhme, Jörg; Furrer, Fabian; Franz, Torsten; Pacher, Christoph; Werner, Reinhard F; Schnabel, Roman

2015-10-30

Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum key distribution requires composable security against coherent attacks for a finite number of distributed quantum states as well as robustness against implementation side channels. Here we present an implementation of continuous-variable quantum key distribution satisfying these requirements. Our implementation is based on the distribution of continuous-variable Einstein-Podolsky-Rosen entangled light. It is one-sided device independent, which means the security of the generated key is independent of any memoryfree attacks on the remote detector. Since continuous-variable encoding is compatible with conventional optical communication technology, our work is a step towards practical implementations of quantum key distribution with state-of-the-art security based solely on telecom components.

4. Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks

NASA Astrophysics Data System (ADS)

Gehring, Tobias; Händchen, Vitus; Duhme, Jörg; Furrer, Fabian; Franz, Torsten; Pacher, Christoph; Werner, Reinhard F.; Schnabel, Roman

2015-10-01

Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum key distribution requires composable security against coherent attacks for a finite number of distributed quantum states as well as robustness against implementation side channels. Here we present an implementation of continuous-variable quantum key distribution satisfying these requirements. Our implementation is based on the distribution of continuous-variable Einstein-Podolsky-Rosen entangled light. It is one-sided device independent, which means the security of the generated key is independent of any memoryfree attacks on the remote detector. Since continuous-variable encoding is compatible with conventional optical communication technology, our work is a step towards practical implementations of quantum key distribution with state-of-the-art security based solely on telecom components.

5. Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks

PubMed Central

Gehring, Tobias; Händchen, Vitus; Duhme, Jörg; Furrer, Fabian; Franz, Torsten; Pacher, Christoph; Werner, Reinhard F.; Schnabel, Roman

2015-01-01

Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum key distribution requires composable security against coherent attacks for a finite number of distributed quantum states as well as robustness against implementation side channels. Here we present an implementation of continuous-variable quantum key distribution satisfying these requirements. Our implementation is based on the distribution of continuous-variable Einstein–Podolsky–Rosen entangled light. It is one-sided device independent, which means the security of the generated key is independent of any memoryfree attacks on the remote detector. Since continuous-variable encoding is compatible with conventional optical communication technology, our work is a step towards practical implementations of quantum key distribution with state-of-the-art security based solely on telecom components. PMID:26514280

6. Independently variable phase and stroke control for a double acting Stirling engine

DOEpatents

Berchowitz, David M.

1983-01-01

A phase and stroke control apparatus for the pistons of a Stirling engine includes a ring on the end of each piston rod in which a pair of eccentrics is arranged in series, torque transmitting relationship. The outer eccentric is rotatably mounted in the ring and is rotated by the orbiting ring; the inner eccentric is mounted on an output shaft. The two eccentrics are mounted for rotation together within the ring during normal operation. A device is provided for rotating one eccentric with respect to another to change the effective eccentricity of the pair of eccentrics. A separately controlled phase adjustment is provided to null the phase change introduced by the change in the orientation of the outer eccentric, and also to enable the phase of the pistons to be changed independently of the stroke change.

7. The biobehavioral family model: testing social support as an additional exogenous variable.

PubMed

Woods, Sarah B; Priest, Jacob B; Roush, Tara

2014-12-01

This study tests the inclusion of social support as a distinct exogenous variable in the Biobehavioral Family Model (BBFM). The BBFM is a biopsychosocial approach to health that proposes that biobehavioral reactivity (anxiety and depression) mediates the relationship between family emotional climate and disease activity. Data for this study included married, English-speaking adult participants (n = 1,321; 55% female; M age = 45.2 years) from the National Comorbidity Survey Replication, a nationally representative epidemiological study of the frequency of mental disorders in the United States. Participants reported their demographics, marital functioning, social support from friends and relatives, anxiety and depression (biobehavioral reactivity), number of chronic health conditions, and number of prescription medications. Confirmatory factor analyses supported the items used in the measures of negative marital interactions, social support, and biobehavioral reactivity, as well as the use of negative marital interactions, friends' social support, and relatives' social support as distinct factors in the model. Structural equation modeling indicated a good fit of the data to the hypothesized model (χ(2)  = 846.04, p = .000, SRMR = .039, CFI = .924, TLI = .914, RMSEA = .043). Negative marital interactions predicted biobehavioral reactivity (β = .38, p < .001), as did relatives' social support, inversely (β = -.16, p < .001). Biobehavioral reactivity predicted disease activity (β = .40, p < .001) and was demonstrated to be a significant mediator through tests of indirect effects. Findings are consistent with previous tests of the BBFM with adult samples, and suggest the important addition of family social support as a predicting factor in the model.

8. Interferometry with independent Bose-Einstein condensates: parity as an EPR/Bell quantum variable

NASA Astrophysics Data System (ADS)

Laloë, F.; Mullin, W. J.

2009-08-01

When independent Bose-Einstein condensates (BEC), described quantum mechanically by Fock (number) states, are sent into interferometers, the measurement of the output port at which the particles are detected provides a binary measurement, with two possible results ±1. With two interferometers and two BEC's, the parity (product of all results obtained at each interferometer) has all the features of an Einstein-Podolsky-Rosen quantity, with perfect correlations predicted by quantum mechanics when the settings (phase shifts of the interferometers) are the same. When they are different, significant violations of Bell inequalities are obtained. These violations do not tend to zero when the number N of particles increases, and can therefore be obtained with arbitrarily large systems, but a condition is that all particles should be detected. We discuss the general experimental requirements for observing such effects, the necessary detection of all particles in correlation, the role of the pixels of the CCD detectors, and that of the alignments of the interferometers in terms of matching of the wave fronts of the sources in the detection regions. Another scheme involving three interferometers and three BEC's is discussed; it leads to Greenberger-Horne-Zeilinger (GHZ) sign contradictions, as in the usual GHZ case with three particles, but for an arbitrarily large number of them. Finally, generalizations of the Hardy impossibilities to an arbitrarily large number of particles are introduced. BEC's provide a large versality for observing violations of local realism in a variety of experimental arrangements.

9. Additional SPIRITS Discoveries of Infrared Transients and Variables with Counterparts in Reference Imaging

NASA Astrophysics Data System (ADS)

Jencson, J. E.; Kasliwal, M. M.; Adams, S.; Cook, D.; Tinyanont, S.; Kwan, S.; Prince, T.; Lau, R. M.; Perley, D.; Masci, F.; Helou, G.; Armus, L.; Surace, J.; Dyk, S. D. Van; Cody, A.; Boyer, M. L.; Bond, H. E.; Monson, A.; Bally, J.; Cao, Y.; Khan, R.; Levesque, E.; Fox, O.; Williams, R.; Whitelock, P. A.; Mohamed, S.; Gehrz, R. D.; Amodeo, S.; Shenoy, D.; Carlon, R.; Cass, A.; Corgan, D.; Dykhoff, D.; Faella, J.; Gburek, T.; Smith, N.; Cantiello, M.; Langer, N.; Ofek, E.; Johansson, J.; Parthasarathy, M.; Hsiao, E.; Phillips, M.; Morrell, N.; Gonzalez, C.; Contreras, C.

2017-03-01

We report the discoveries of mid-infrared transients/eruptive variables found by the Spitzer InfraRed Intensive Transients Survey (SPIRITS) using Spitzer Early Release Data (ATel #6644, #7929, #8688, #8940, #9434).

10. Additional SPIRITS Discoveries of Infrared Transients and Variables without Counterparts in Reference Imaging

NASA Astrophysics Data System (ADS)

Jencson, J. E.; Kasliwal, M. M.; Adams, S.; Cook, D.; Tinyanont, S.; Kwan, S.; Prince, T.; Lau, R. M.; Perley, D.; Masci, F.; Helou, G.; Armus, L.; Surace, J.; Dyk, S. D. Van; Cody, A.; Boyer, M. L.; Bond, H. E.; Monson, A.; Bally, J.; Cao, Y.; Khan, R.; Levesque, E.; Fox, O.; Williams, R.; Whitelock, P. A.; Mohamed, S.; Gehrz, R. D.; Amodeo, S.; Shenoy, D.; Carlon, R.; Cass, A.; Corgan, D.; Dykhoff, D.; Faella, J.; Gburek, T.; Smith, N.; Cantiello, M.; Langer, N.; Ofek, E.; Johansson, J.; Parthasarathy, M.; Hsiao, E.; Phillips, M.; Morrell, N.; Gonzalez, C.; Contreras, C.

2017-03-01

We report the discoveries of mid-infrared transients/eruptive variables found by the Spitzer InfraRed Intensive Transients Survey (SPIRITS) using Spitzer Early Release Data (ATel #6644, #7929, #8688, #8940, #9434).

11. Improving Performance of Power Systems with Large-scale Variable Generation Additions

SciTech Connect

Makarov, Yuri V.; Etingov, Pavel V.; Samaan, Nader A.; Lu, Ning; Ma, Jian; Subbarao, Krishnappa; Du, Pengwei; Kannberg, Landis D.

2012-07-22

A power system with large-scale renewable resources, like wind and solar generation, creates significant challenges to system control performance and reliability characteristics because of intermittency and uncertainties associated with variable generation. It is important to quantify these uncertainties, and then incorporate this information into decision-making processes and power system operations. This paper presents three approaches to evaluate the flexibility needed from conventional generators and other resources in the presence of variable generation as well as provide this flexibility from a non-traditional resource – wide area energy storage system. These approaches provide operators with much-needed information on the likelihood and magnitude of ramping and capacity problems, and the ability to dispatch available resources in response to such problems.

12. Addition of simultaneous heat and solute transport and variable fluid viscosity to SEAWAT

USGS Publications Warehouse

Thorne, D.; Langevin, C.D.; Sukop, M.C.

2006-01-01

SEAWAT is a finite-difference computer code designed to simulate coupled variable-density ground water flow and solute transport. This paper describes a new version of SEAWAT that adds the ability to simultaneously model energy and solute transport. This is necessary for simulating the transport of heat and salinity in coastal aquifers for example. This work extends the equation of state for fluid density to vary as a function of temperature and/or solute concentration. The program has also been modified to represent the effects of variable fluid viscosity as a function of temperature and/or concentration. The viscosity mechanism is verified against an analytical solution, and a test of temperature-dependent viscosity is provided. Finally, the classic Henry-Hilleke problem is solved with the new code. ?? 2006 Elsevier Ltd. All rights reserved.

13. Maturation of poultry G-I microbiome during 42d of growth is independent of organic acid feed additives

Technology Transfer Automated Retrieval System (TEKTRAN)

Poultry remains a major source of foodborne infections in the U.S. and globally. A variety of additives with presumed anti-microbial and/or growth-promoting effects are commonly added to poultry feed, yet the effects of these additives on the ecology of the gastro-intestinal microbial community (th...

14. On the JWKB solution of the uniformly lengthening pendulum via change of independent variable in the Bessel's equation

NASA Astrophysics Data System (ADS)

Deniz, Coşkun

2017-01-01

Common recipe for the lengthening pendulum (LP) involves some change of variables to give a relationship with the Bessel's equation. In this work, conventional semiclassical JWKB solution (named after Jeffreys, Wentzel, Kramers and Brillouin) of the LP is being obtained by first transforming the related Bessel's equation into the normal form `via the suggested change of independent variable'. JWKB approximation of the first-order Bessel functions ( ν=1) of both types along with their zeros are being obtained analytically with a very good accuracy as a result of the appropriately chosen associated initial values and they are extended to the neighbouring orders ( ν=0 and 2) by the recursion relations. The required initial values are also being studied and a quantization rule regarding the experimental LP parameters is being determined. Although common numerical methods given in the literature require adiabatic LP systems where the lengthening rate is slow, JWKB solution presented here can safely be used for higher lengthening rates and a criterion for its validity is determined by the JWKB applicability criterion given in the literature. As a result, the semiclassical JWKB method which is normally used for the quantum mechanical and optical waveguide systems is applied to the classical LP system successfully.

15. The Effects of A Learning Experience Upon Preference for Complexity and Asymmetry; Variables of Perceptual Field Independence, and the Ability to Handle Visual Information. Final Report.

ERIC Educational Resources Information Center

McWhinnie, Harold J.

The purpose of this study was to investigate the effects of a specific type of perceptual training upon the aesthetic preference for complexity-asymmetry, ability to handle visual information, select variables of perceptual field-independence, and selected variables of creative thinking. A total of 300 fourth, fifth, and sixth grade children in…

16. Variability of the Estimated Glomerular Filtration Rate in the First Year after Kidney Transplantation Is an Independent Risk Factor for Poor Renal Allograft Outcomes: A Retrospective Cohort Study

PubMed Central

Choi, Hoon Young; Huh, Kyu Ha; Lee, Jae Geun; Song, Mi Kyung; Kim, Myoung Soo; Kim, Yu Seun; Kim, Beom Seok

2016-01-01

Renal function in the first year after kidney transplantation (KT) can predict long-term renal graft survival. This study investigated whether estimated glomerular filtration rate (eGFR) variability during the first year after KT is a risk factor for poor renal allograft outcomes. This retrospective cohort study included 3077 patients who underwent repeated eGFR measurements for 1 year after KT at Severance Hospital Transplantation Center between 1979 and 2012. The eGFR variability during the first year after KT was the predictor. The patients were divided into four quartile groups of eGFR variability according to the coefficient of variation for eGFR (eGFR-CV). We selected a cutoff of eGFR-CV for graft failure and performed the sensitivity analyses. The graft outcome was worse in the highest quartile group of eGFR variability than in the other groups among all patients (Q4: HR 1.631, 95% CI 1.278–2.081; p < 0.0001) and among patients without AR (Q4: HR 1.425, 95% CI 1.024–1.982; p = 0.0358) after adjusting for eGFR at 1 year after KT and other covariates. Additionally, all-cause mortality was higher in this highest quartile group than in the other groups among all patients but not among patients without AR. Higher eGFR-CVs than the cutoff were significantly associated with a high risk of graft failure among all patients (HR 1.670, 95% CI 1.395–2.000; p < 0.0001) and among patients without AR (HR 1.899, 95% CI 1.457–2.477; p < 0.0001) after fully adjusting for covariates. For all-cause mortality, a higher eGFR-CV was an independent risk factor among all patients but not among patients without AR after adjusting for covariates. eGFR variability in the first year after KT is an independent risk factor for poor renal allograft outcomes. PMID:27973553

17. Explaining Variability in Retrieval Times for Addition Produced by Students with Mathematical Learning Difficulties

ERIC Educational Resources Information Center

Hopkins, Sarah L.; Lawson, Michael J.

2004-01-01

Predictors of retrieval times produced by students having difficulty developing a reliance on retrieval for simple addition were discovered. The findings support the notion that separate limitations operate in working memory when retrieval occurs and call into question the use of the term "retrieval deficit" to explain difficulties…

18. Enhancing quantum entanglement for continuous variables by a coherent superposition of photon subtraction and addition

SciTech Connect

Lee, Su-Yong; Kim, Ho-Joon; Ji, Se-Wan; Nha, Hyunchul

2011-07-15

We investigate how the entanglement properties of a two-mode state can be improved by performing a coherent superposition operation ta+ra{sup {dagger}} of photon subtraction and addition, proposed by Lee and Nha [Phys. Rev. A 82, 053812 (2010)], on each mode. We show that the degree of entanglement, the Einstein-Podolsky-Rosen-type correlation, and the performance of quantum teleportation can be all enhanced for the output state when the coherent operation is applied to a two-mode squeezed state. The effects of the coherent operation are more prominent than those of the mere photon subtraction a and the addition a{sup {dagger}} particularly in the small-squeezing regime, whereas the optimal operation becomes the photon subtraction (case of r=0) in the large-squeezing regime.

19. Numerical solution of the compressible Navier-Stokes equations using density gradients as additional dependent variables. M.S. Thesis

NASA Technical Reports Server (NTRS)

Kwon, J. H.

1977-01-01

Numerical solution of two dimensional, time dependent, compressible viscous Navier-Stokes equations about arbitrary bodies was treated using density gradients as additional dependent variables. Thus, six dependent variables were computed with the SOR iteration method. Besides formulation for pressure gradient terms, a formulation for computing the body density was presented. To approximate the governing equations, an implicit finite difference method was employed. In computing the solution for the flow about a circular cylinder, a problem arose near the wall at both stagnation points. Thus, computations with various conditions were tried to examine the problem. Also, computations with and without formulations are compared. The flow variables were computed on 37 by 40 field first, then on an 81 by 40 field.

20. Independent and additive contributions of postvictory testosterone and social experience to the development of the winner effect.

PubMed

Fuxjager, Matthew J; Oyegbile, Temitayo O; Marler, Catherine A

2011-09-01

The processes through which salient social experiences influence future behavior are not well understood. Winning fights, for example, can increase the odds of future victory, yet little is known about the internal mechanisms that underlie such winner effects. Here, we use the territorial California mouse (Peromyscus californicus) to investigate how the effects of postvictory testosterone (T) release and winning experience individually mediate positive changes in future winning ability and antagonistic behavior. Male mice were castrated and implanted with T capsules to maintain basal levels of this hormone. We found that males form a robust winner effect if they win three separate territorial disputes and experience a single T surge roughly 45 min after each encounter. Meanwhile, males exhibit only an intermediate winner effect if they either 1) acquire three previous wins but do not experience a change in postvictory T or 2) acquire no previous wins but experience three separate T pulses. The results indicate that the effect of postvictory T must be coupled with that of winning experience to trigger the maximum positive shift in winning ability, which highlights the importance of social context in the development of the winner effect. At the same time, however, postvictory T and winning experience are each capable of increasing future winning ability independently, and this finding suggests that these two factors drive plasticity in antagonistic behavior via distinct mechanistic channels. More broadly, our data offer insight into the possible ways in which various species might be able to adjust their behavioral repertoire in response to social interactions through mechanisms that are unlinked from the effects of gonadal steroid action.

1. ADPROCLUS: a graphical user interface for fitting additive profile clustering models to object by variable data matrices.

PubMed

Wilderjans, Tom F; Ceulemans, Eva; Van Mechelen, Iven; Depril, Dirk

2011-03-01

In many areas of psychology, one is interested in disclosing the underlying structural mechanisms that generated an object by variable data set. Often, based on theoretical or empirical arguments, it may be expected that these underlying mechanisms imply that the objects are grouped into clusters that are allowed to overlap (i.e., an object may belong to more than one cluster). In such cases, analyzing the data with Mirkin's additive profile clustering model may be appropriate. In this model: (1) each object may belong to no, one or several clusters, (2) there is a specific variable profile associated with each cluster, and (3) the scores of the objects on the variables can be reconstructed by adding the cluster-specific variable profiles of the clusters the object in question belongs to. Until now, however, no software program has been publicly available to perform an additive profile clustering analysis. For this purpose, in this article, the ADPROCLUS program, steered by a graphical user interface, is presented. We further illustrate its use by means of the analysis of a patient by symptom data matrix.

2. Design of experiments with multiple independent variables: a resource management perspective on complete and reduced factorial designs.

PubMed

Collins, Linda M; Dziak, John J; Li, Runze

2009-09-01

An investigator who plans to conduct an experiment with multiple independent variables must decide whether to use a complete or reduced factorial design. This article advocates a resource management perspective on making this decision, in which the investigator seeks a strategic balance between service to scientific objectives and economy. Considerations in making design decisions include whether research questions are framed as main effects or simple effects; whether and which effects are aliased (confounded) in a particular design; the number of experimental conditions that must be implemented in a particular design and the number of experimental subjects the design requires to maintain the desired level of statistical power; and the costs associated with implementing experimental conditions and obtaining experimental subjects. In this article 4 design options are compared: complete factorial, individual experiments, single factor, and fractional factorial. Complete and fractional factorial designs and single-factor designs are generally more economical than conducting individual experiments on each factor. Although relatively unfamiliar to behavioral scientists, fractional factorial designs merit serious consideration because of their economy and versatility.

3. Plate/shell structure topology optimization of orthotropic material for buckling problem based on independent continuous topological variables

NASA Astrophysics Data System (ADS)

Ye, Hong-Ling; Wang, Wei-Wei; Chen, Ning; Sui, Yun-Kang

2017-03-01

The purpose of the present work is to study the buckling problem with plate/shell topology optimization of orthotropic material. A model of buckling topology optimization is established based on the independent, continuous, and mapping method, which considers structural mass as objective and buckling critical loads as constraints. Firstly, composite exponential function (CEF) and power function (PF) as filter functions are introduced to recognize the element mass, the element stiffness matrix, and the element geometric stiffness matrix. The filter functions of the orthotropic material stiffness are deduced. Then these filter functions are put into buckling topology optimization of a differential equation to analyze the design sensitivity. Furthermore, the buckling constraints are approximately expressed as explicit functions with respect to the design variables based on the first-order Taylor expansion. The objective function is standardized based on the second-order Taylor expansion. Therefore, the optimization model is translated into a quadratic program. Finally, the dual sequence quadratic programming (DSQP) algorithm and the global convergence method of moving asymptotes algorithm with two different filter functions (CEF and PF) are applied to solve the optimal model. Three numerical results show that DSQP&CEF has the best performance in the view of structural mass and discretion.

4. Reflecting Solutions of High Order Elliptic Differential Equations in Two Independent Variables Across Analytic Arcs. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Carleton, O.

1972-01-01

Consideration is given specifically to sixth order elliptic partial differential equations in two independent real variables x, y such that the coefficients of the highest order terms are real constants. It is assumed that the differential operator has distinct characteristics and that it can be factored as a product of second order operators. By analytically continuing into the complex domain and using the complex characteristic coordinates of the differential equation, it is shown that its solutions, u, may be reflected across analytic arcs on which u satisfies certain analytic boundary conditions. Moreover, a method is given whereby one can determine a region into which the solution is extensible. It is seen that this region of reflection is dependent on the original domain of difinition of the solution, the arc and the coefficients of the highest order terms of the equation and not on any sufficiently small quantities; i.e., the reflection is global in nature. The method employed may be applied to similar differential equations of order 2n.

5. Autologous temporomandibular joint reconstruction independent of exogenous additives: a proof-of-concept study for guided self-generation

PubMed Central

Wei, Jiao; Herrler, Tanja; Han, Dong; Liu, Kai; Huang, Rulin; Guba, Markus; Dai, Chuanchang; Li, Qingfeng

2016-01-01

Joint defects are complex and difficult to reconstruct. By exploiting the body’s own regenerative capacity, we aimed to individually generate anatomically precise neo-tissue constructs for autologous joint reconstruction without using any exogenous additives. In a goat model, CT scans of the mandibular condyle including articular surface and a large portion of the ascending ramus were processed using computer-aided design and manufacturing. A corresponding hydroxylapatite negative mold was printed in 3D and temporarily embedded into the transition zone of costal periosteum and perichondrium. A demineralized bone matrix scaffold implanted on the contralateral side served as control. Neo-tissue constructs obtained by guided self-generation exhibited accurate configuration, robust vascularization, biomechanical stability, and function. After autologous replacement surgery, the constructs showed stable results with similar anatomical, histological, and functional findings compared to native controls. Further studies are required to assess long-term outcome and possible extensions to other further applications. The absence of exogenous cells, growth factors, and scaffolds may facilitate clinical translation of this approach. PMID:27892493

6. Testing a Model of the Relationship of Demographic, Affective, and Fitness Variables to Academic Achievement among Non-Science Majors at an Independent University

NASA Astrophysics Data System (ADS)

Dutra, Andrew Martin

7. Independent vector analysis based on overlapped cliques of variable width for frequency-domain blind signal separation

NASA Astrophysics Data System (ADS)

Lee, Intae; Jang, Gil-Jin

2012-12-01

A novel method is proposed to improve the performance of independent vector analysis (IVA) for blind signal separation of acoustic mixtures. IVA is a frequency-domain approach that successfully resolves the well-known permutation problem by applying a spherical dependency model to all pairs of frequency bins. The dependency model of IVA is equivalent to a single clique in an undirected graph; a clique in graph theory is defined as a subset of vertices in which any pair of vertices is connected by an undirected edge. Therefore, IVA imposes the same amount of statistical dependency on every pair of frequency bins, which may not match the characteristics of real-world signals. The proposed method allows variable amounts of statistical dependencies according to the correlation coefficients observed in real acoustic signals and, hence, enables more accurate modeling of statistical dependencies. A number of cliques constitutes the new dependency graph so that neighboring frequency bins are assigned to the same clique, while distant bins are assigned to different cliques. The permutation ambiguity is resolved by overlapped frequency bins between neighboring cliques. For speech signals, we observed especially strong correlations across neighboring frequency bins and a decrease in these correlations with an increase in the distance between bins. The clique sizes are either fixed, or determined by the reciprocal of the mel-frequency scale to impose a wider dependency on low-frequency components. Experimental results showed improved performances over conventional IVA. The signal-to-interference ratio improved from 15.5 to 18.8 dB on average for seven different source locations. When we varied the clique sizes according to the observed correlations, the stability of the proposed method increased with a large number of cliques.

8. Complementary Aerodynamic Performance Datasets for Variable Speed Power Turbine Blade Section from Two Independent Transonic Turbine Cascades

NASA Technical Reports Server (NTRS)

Flegel, Ashlie B.; Welch, Gerard E.; Giel, Paul W.; Ames, Forrest E.; Long, Jonathon A.

2015-01-01

9. AN INDEPENDENT ANALYSIS OF THE BROWN DWARF ATMOSPHERE MONITORING (BAM) DATA: LARGE-AMPLITUDE VARIABILITY IS RARE OUTSIDE THE L/T TRANSITION

SciTech Connect

2014-12-20

Observations of variability can provide valuable information about the processes of cloud formation and dissipation in brown dwarf atmospheres. Here we report the results of an independent analysis of archival data from the Brown dwarf Atmosphere Monitoring (BAM) program. Time series data for 14 L and T dwarfs reported to be significantly variable over timescales of hours were analyzed. We confirm large-amplitude variability (amplitudes >2%) for 4 out of 13 targets and place upper limits of 0.7%-1.6% on variability in the remaining sample. For two targets we find evidence of weak variability at amplitudes of 1.3% and 1.6%. Based on our revised classification of variable objects in the BAM study, we find strong variability outside the L/T transition to be rare at near infrared wavelengths. From a combined sample of 81 L0-T9 dwarfs from the revised BAM sample and the variability survey of Radigan et al., we infer an overall observed frequency for large-amplitude variability outside the L/T transition of 3.2{sub −1.8}{sup +2.8}%, in contrast to 24{sub −9}{sup +11}% for L9-T3.5 spectral types. We conclude that while strong variability is not limited to the L/T transition, it occurs more frequently in this spectral type range, indicative of larger or more highly contrasting cloud features at these spectral types.

10. Variability in Ozone in the Tropical Tropopause Region from the 1998-2000 SHADOZ (Southern Hemisphere ADditional OZonesondes) Data

NASA Astrophysics Data System (ADS)

Thompson, A. M.; Witte, J. C.; Oltmans, S. J.; Schmidlin, F. J.

2002-05-01

The first view of stratospheric and tropospheric ozone variability in the southern hemisphere tropics is provided by a 3-year, 10-site record of ozone soundings from the Southern Hemisphere ADditional OZonesondes (SHADOZ) network: (http://code916.gsfc.nasa.gov/Data_services/shadoz). Observations covering 1998-2000 were made over Ascension Island; Nairobi, Kenya; Irene, South Africa; Réunion Island; Watukosek, Java; Fiji; Tahiti; American Samoa; San Cristóbal, Galapagos; Natal, Brazil. Taking the TTL (tropical tropopause layer) as the region between 12 and 17 km, we examine ozone variability in this region on a week-to-week and seasonal basis. The TTL layer is lower in September-October-November than in March-April-May, when ozone is a minimum at most SHADOZ stations. A zonal wave-one pattern is apparent in column-integrated TTL ozone because ozone mixing ratios are greater over the Atlantic and adjacent continents than over the Pacific and eastern Indian Ocean. The wave-one persists all year with varying magnitude and appears to be due to general circulation - with subsidence over the Atlantic and frequent deep convection over the Pacific and Indian Ocean. The variability of deep convection - most prominent at Java, Fiji, Samoa and Natal - is explored in time-vs-altitude ozone curtains. Stratospheric incursions into the troposphere are most prominent in soundings at Irene and Réunion Island.

11. Variability in Ozone in the Tropical Tropopause Region from the 1998-2000 SHADOZ (Southern Hemisphere ADditional OZonesondes) Data

NASA Technical Reports Server (NTRS)

Thompson, Anne M.; Witte, J. C.; Oltmans, S. J.; Schmidlin, F. J.

2002-01-01

The first view of stratospheric and tropospheric ozone variability in the southern hemisphere tropics is provided by a 3-year, 10-site record of ozone soundings from the Southern Hemisphere ADditional OZonesondes (SHADOZ) network. Observations covering 1998-2000 were made over Ascension Island; Nairobi, Kenya; Irene, South Africa; Reunion Island; Watukosek, Java; Fiji; Tahiti; American Samoa; San Cristobal, Galapagos; Natal, Brazil. Taking the TTL (tropical tropopause layer) as the region between 12 and 17 km, we examine ozone variability in this region on a week-to-week and seasonal basis. The TTL layer is lower in September-October-November than in March-April-May, when ozone is a minimum at most SHADOZ stations. A zonal wave-one pattern is apparent in column-integrated TTL ozone because ozone mixing ratios are greater over the Atlantic and adjacent continents than over the Pacific and eastern Indian Ocean. The wave-one persists all year with varying magnitude and appears to be due to general circulation - with subsidence over the Atlantic and frequent deep convection over the Pacific and Indian Ocean. The variability of deep convection - most prominent at Java, Fiji, Samoa and Natal - is explored in time-vs-altitude ozone curtains. Stratospheric incursions into the troposphere are most prominent in soundings at Irene and Reunion Island.

12. Southern Hemisphere Additional Ozonesondes (SHADOZ) 1998-2000 tropical ozone climatology 2. Tropospheric variability and the zonal wave-one

NASA Astrophysics Data System (ADS)

Thompson, Anne M.; Witte, Jacquelyn C.; Oltmans, Samuel J.; Schmidlin, Francis J.; Logan, Jennifer A.; Fujiwara, Masatomo; Kirchhoff, Volker W. J. H.; Posny, FrançOise; Coetzee, Gert J. R.; Hoegger, Bruno; Kawakami, Shuji; Ogawa, Toshihiro; Fortuin, J. P. F.; Kelder, H. M.

2003-01-01

The first view of stratospheric and tropospheric ozone variability in the Southern Hemisphere tropics is provided by a 3-year record of ozone soundings from the Southern Hemisphere Additional Ozonesondes (SHADOZ) network (http://croc.gsfc.nasa.gov/shadoz). Observations covering 1998-2000 were made over Ascension Island, Nairobi (Kenya), Irene (South Africa), Réunion Island, Watukosek (Java), Fiji, Tahiti, American Samoa, San Cristóbal (Galapagos), and Natal (Brazil). Total, stratospheric, and tropospheric column ozone amounts usually peak between August and November. Other features are a persistent zonal wave-one pattern in total column ozone and signatures of the quasi-biennial oscillation (QBO) in stratospheric ozone. The wave-one is due to a greater concentration of free tropospheric ozone over the tropical Atlantic than the Pacific and appears to be associated with tropical general circulation and seasonal pollution from biomass burning. Tropospheric ozone over the Indian and Pacific Oceans displays influences of the waning 1997-1998 El Niño, seasonal convection, and pollution transport from Africa. The most distinctive feature of SHADOZ tropospheric ozone is variability in the data, e.g., a factor of 3 in column amount at 8 of 10 stations. Seasonal and monthly means may not be robust quantities because statistics are frequently not Gaussian even at sites that are always in tropical air. Models and satellite retrievals should be evaluated on their capability for reproducing tropospheric variability and fine structure. A 1999-2000 ozone record from Paramaribo, Surinam (6°N, 55°W) (also in SHADOZ) shows a marked contrast to southern tropical ozone because Surinam is often north of the Intertropical Convergence Zone (ITCZ). A more representative tropospheric ozone climatology for models and satellite retrievals requires additional Northern Hemisphere tropical data.

13. Integrated fuzzy concentration addition-independent action (IFCA-IA) model outperforms two-stage prediction (TSP) for predicting mixture toxicity.

PubMed

Wang, Zhuang; Chen, Jingwen; Huang, Liping; Wang, Ying; Cai, Xiyun; Qiao, Xianliang; Dong, Yuying

2009-02-01

Mixture toxicities were determined for 12 industrial organic chemicals bearing four different modes of toxic action (MOAs) to Vibrio fischeri, to compare the predictability of the integrated fuzzy concentration addition-independent action (IFCA-IA) model and the two-stage prediction (TSP) model. Three mixtures were designed: The first and second mixtures were based on the ratios of each component at the 1% and 50% effect concentrations (EC(1) and EC(50)), respectively; and the third mixture contained an equimolar ratio of individual components. For the EC(1), EC(50) and equimolar ratio, prediction errors from the IFCA-IA model at the 50% experimental mixture effects were 0.3%, 6% and 0.6%, respectively; while for the TSP model, the corresponding errors were 2.8%, 19% and 24%, respectively. Thus, the IFCA-IA model performed better than the TSP model. The IFCA-IA model calculated two weight coefficients from the molecular structural descriptors, which weigh the relation between concentration addition (CA) and independent action (IA) through the fuzzy membership functions. Thus, MOAs are not pre-requisites for mixture toxicity prediction by the IFCA-IA approach, implying the practicability of this method in toxicity assessment of mixtures.

14. Continuous-variable quantum teleportation with non-Gaussian entangled states generated via multiple-photon subtraction and addition

NASA Astrophysics Data System (ADS)

Wang, Shuai; Hou, Li-Li; Chen, Xian-Feng; Xu, Xue-Fen

2015-06-01

We theoretically analyze the Einstein-Podolsky-Rosen (EPR) correlation, the quadrature squeezing, and the continuous-variable quantum teleportation when considering non-Gaussian entangled states generated by applying multiple-photon subtraction and multiple-photon addition to a two-mode squeezed vacuum state (TMSVs). Our results indicate that in the case of the multiple-photon-subtracted TMSVs with symmetric operations, the corresponding EPR correlation, the two-mode squeezing degree, the sum squeezing, and the fidelity of teleporting a coherent state or a squeezed vacuum state can be enhanced for any squeezing parameter r and these enhancements increase with the number of subtracted photons in the low-squeezing regime, while asymmetric multiple-photon subtractions will generally reduce these quantities. For the multiple-photon-added TMSVs, although it holds stronger entanglement, its EPR correlation, two-mode squeezing, sum squeezing, and the fidelity of a coherent state are always smaller than that of the TMSVs. Only when considering the case of teleporting a squeezed vacuum state does the symmetric photon addition make somewhat of an improvement in the fidelity for large-squeezing parameters. In addition, we analytically prove that a one-mode multiple-photon-subtracted TMSVs is equivalent to that of the one-mode multiple-photon-added one. And one-mode multiple-photon operations will diminish the above four quantities for any squeezing parameter r .

15. Mitigation of Variability among 3D Echocardiography-Derived Regional Strain Values Acquired by Multiple Ultrasound Systems by Vendor Independent Analysis

PubMed Central

Streiff, Cole; Zhu, Meihua; Shimada, Eriko; Sahn, David J.; Ashraf, Muhammad

2016-01-01

Introduction This study compared the variability of 3D echo derived circumferential and longitudinal strain values computed from vendor-specific and vendor-independent analyses of images acquired using ultrasound systems from different vendors. Methods Ten freshly harvested porcine hearts were studied. Each heart was mounted on a custom designed phantom and driven to simulate normal cardiac motion. Cardiac rotation was digitally controlled and held constant at 5°, while pumped stroke volume (SV) ranged from 30-70ml. Full-volume image data was acquired using three different ultrasound systems from different vendors. The image data was analyzed for longitudinal and circumferential strains (LS, CS) using both vendor-specific and vendor-independent analysis packages. Results Good linear relationships were observed for each vendor-specific analysis package for both CS and LS at the mid-anterior segment, with correlation coefficients ranging from 0.82–0.91 (CS) and 0.86–0.89 (LS). Comparable linear regressions were observed for results determined by a vendor independent program (CS: R = 0.82–0.89; LS: R = 0.86–0.89). Variability between analysis packages was examined via a series of ANOVA tests. A statistical difference was found between vendor-specific analysis packages (p<0.001), while no such difference was observed between ultrasound systems when using the vendor-independent program (p>0.05). Conclusions Circumferential and longitudinal regional strain values differ when quantified by vendor-specific analysis packages; however, this variability is mitigated by use of a vendor-independent quantification method. These results suggest that echocardiograms acquired using different ultrasound systems could be meaningfully compared using vendor-independent software. PMID:27149685

16. THE GJ1214 SUPER-EARTH SYSTEM: STELLAR VARIABILITY, NEW TRANSITS, AND A SEARCH FOR ADDITIONAL PLANETS

SciTech Connect

Berta, Zachory K.; Charbonneau, David; Bean, Jacob; Irwin, Jonathan; Burke, Christopher J.; Desert, Jean-Michel; Nutzman, Philip; Falco, Emilio E.

2011-07-20

The super-Earth GJ1214b transits a nearby M dwarf that exhibits a 1% intrinsic variability in the near-infrared. Here, we analyze new observations to refine the physical properties of both the star and planet. We present three years of out-of-transit photometric monitoring of the stellar host GJ1214 from the MEarth Observatory and find the rotation period to be long, most likely an integer multiple of 53 days, suggesting low levels of magnetic activity and an old age for the system. We show that such variability will not pose significant problems to ongoing studies of the planet's atmosphere with transmission spectroscopy. We analyze two high-precision transit light curves from ESO's Very Large Telescope (VLT) along with seven others from the MEarth and Fred Lawrence Whipple Observatory 1.2 m telescopes, finding physical parameters for the planet that are consistent with previous work. The VLT light curves show tentative evidence for spot occultations during transit. Using two years of MEarth light curves, we place limits on additional transiting planets around GJ1214 with periods out to the habitable zone of the system. We also improve upon the previous photographic V-band estimate for the star, finding V = 14.71 {+-} 0.03.

17. Variable Temperature Stress in the Nematode Caenorhabditis elegans (Maupas) and Its Implications for Sensitivity to an Additional Chemical Stressor

PubMed Central

Svendsen, Claus; Spurgeon, David J.

2016-01-01

A wealth of studies has investigated how chemical sensitivity is affected by temperature, however, almost always under different constant rather than more realistic fluctuating regimes. Here we compared how the nematode Caenorhabditis elegans responds to copper at constant temperatures (8–24°C) and under fluctuation conditions of low (±4°C) and high (±8°C) amplitude (averages of 12, 16, 20°C and 16°C respectively). The DEBkiss model was used to interpret effects on energy budgets. Increasing constant temperature from 12–24°C reduced time to first egg, life-span and population growth rates consistent with temperature driven metabolic rate change. Responses at 8°C did not, however, accord with this pattern (including a deviation from the Temperature Size Rule), identifying a cold stress effect. High amplitude variation and low amplitude variation around a mean temperature of 12°C impacted reproduction and body size compared to nematodes kept at the matching average constant temperatures. Copper exposure affected reproduction, body size and life-span and consequently population growth. Sensitivity to copper (EC50 values), was similar at intermediate temperatures (12, 16, 20°C) and higher at 24°C and especially the innately stressful 8°C condition. Temperature variation did not increase copper sensitivity. Indeed under variable conditions including time at the stressful 8°C condition, sensitivity was reduced. DEBkiss identified increased maintenance costs and increased assimilation as possible mechanisms for cold and higher copper concentration effects. Model analysis of combined variable temperature effects, however, demonstrated no additional joint stressor response. Hence, concerns that exposure to temperature fluctuations may sensitise species to co-stressor effects seem unfounded in this case. PMID:26784453

18. Stable isotopes provide independent support for the use of mesowear variables for inferring diets in African antelopes.

PubMed

Louys, Julien; Ditchfield, Peter; Meloro, Carlo; Elton, Sarah; Bishop, Laura C

2012-11-07

We examine the relationship between mesowear variables and carbon and nitrogen isotopes in 16 species of African antelope (Mammalia: Bovidae). We show significant differences in carbon and nitrogen isotope values between individuals exhibiting sharp versus round cusps, and high versus low occlusal relief. We show significant correlations between mesowear variables and both carbon and nitrogen isotopes. We find significant correlations between mesowear score and nitrogen, but not carbon isotopes. Finally, we find no significant correlations between hypsodonty index and either isotope examined. Our results provide strong support for the use of mesowear variables in palaeodietary reconstructions of antelopes. Our results further suggest that for the antelopes examined here, mesowear signals are a direct result of diet, while hyposodonty may be the result of phylogenetic legacy.

19. Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is an Independent Determinant of Carotid Intima-Media Thickness in Patients With Type 2 Diabetes

PubMed Central

Takenouchi, Akiko; Tsuboi, Ayaka; Kitaoka, Kaori; Minato, Satomi; Kurata, Miki; Fukuo, Keisuke; Kazumi, Tsutomu

2017-01-01

Background Studies demonstrated that visit-to-visit variability in low-density lipoprotein cholesterol (LDLC) is an independent predictor of cardiovascular events in subjects with coronary artery disease. Whether visit-to-visit variability in LDLC levels affects subclinical atherosclerosis is unknown. This study sought to evaluate the role of visit-to-visit variability in LDLC levels on subclinical atherosclerosis. Methods We evaluated 162 type 2 diabetic patients with measurement of carotid intima-media thickness (IMT). Intrapersonal mean and standard deviation (SD) of six measurements of LDLC during 12 months were calculated. Multivariate linear regressions assessed the independent correlates of carotid IMT. Results The mean and SD of LDLC were 112 ± 22 and 15 ± 10 mg/dL, respectively, and 43.2% of patients were on hypolipidemic drugs. Age (standardized β = 0.355, P < 0.001), male sex (standardized β = 0.234, P = 0.002) and SD-LDLC (standardized β = 0.201, P = 0.009) emerged as independent determinants of carotid maximum IMT independently of mean LDLC levels, body mass index (BMI), waist circumference, duration and treatment of diabetes, means and SDs of glycemic and other lipid variables, and uses of hypolipidemic and anti-hypertensive medications (R2 = 0.15). Results did not change when mean IMT was used instead of maximum IMT. After controlling for age and sex, maximum IMT was thicker in patients with the highest compared to those with other three quartiles of SD-LDLC combined (1.14 ± 0.04 (SE) vs. 1.01 ± 0.02 mm, P = 0.01). Independent determinants of SD-LDLC were mean LDLC, use of hypolipidemic drugs, fasting triglyceride and visit-to-visit variability in HbA1c. Conclusions Consistency of LDLC levels may be important to subclinical atherosclerosis in real-world patients with type 2 diabetes. It may be important for patients on lipid-lowering drugs to prevent non-compliance. PMID:28270891

20. The Southern Hemisphere Additional Ozonesondes (SHADOZ) 1998-2002 Tropical Ozone Climatology. 3; Instrumentation and Station-to-Station Variability

NASA Technical Reports Server (NTRS)

Thompson, Anne M.; Witte, Jacqueline C.; Smit, Herman G. J.; Oltmans, Samuel J.; Johnson, Bryan J.; Kirchhoff, Volker W. J. H.; Schmidlin, Francis J.

2004-01-01

1. STAT4 Associates with SLE Through Two Independent Effects that Correlate with Gene Expression and Act Additively with IRF5 to Increase Risk

PubMed Central

Abelson, Anna-Karin; Delgado-Vega, Angélica M.; Kozyrev, Sergey V.; Sánchez, Elena; Velázquez-Cruz, Rafael; Eriksson, Niclas; Wojcik, Jerome; Reddy, Prasad Linga; Lima, Guadalupe; D’Alfonso, Sandra; Migliaresi, Sergio; Baca, Vicente; Orozco, Lorena; Witte, Torsten; Ortego-Centeno, Norberto; Abderrahim, Hadi; Pons-Estel, Bernardo A.; Gutiérrez, Carmen; Suárez, Ana; González-Escribano, Maria Francisca; Martin, Javier; Alarcón-Riquelme, Marta E.

2013-01-01

Objectives To confirm and define the genetic association of STAT4 and systemic lupus erythematosus, investigate the possibility of correlations with differential splicing and/or expression levels, and genetic interaction with IRF5. Methods 30 tag SNPs were genotyped in an independent set of Spanish cases and controls. SNPs surviving correction for multiple tests were genotyped in 5 new sets of cases and controls for replication. STAT4 cDNA was analyzed by 5’-RACE PCR and sequencing. Expression levels were measured by quantitative PCR. Results In the fine-mapping, four SNPs were significant after correction for multiple testing, with rs3821236 and rs3024866 as the strongest signals, followed by the previously associated rs7574865, and by rs1467199. Association was replicated in all cohorts. After conditional regression analyses, two major independent signals represented by SNPs rs3821236 and rs7574865, remained significant across the sets. These SNPs belong to separate haplotype blocks. High levels of STAT4 expression correlated with SNPs rs3821236, rs3024866 (both in the same haplotype block) and rs7574865 but not with other SNPs. We also detected transcription of alternative tissue-specific exons 1, indicating presence of tissue-specific promoters of potential importance in the expression of STAT4. No interaction with associated SNPs of IRF5 was observed using regression analysis. Conclusions These data confirm STAT4 as a susceptibility gene for SLE and suggest the presence of at least two functional variants affecting levels of STAT4. Our results also indicate that both genes STAT4 and IRF5 act additively to increase risk for SLE. PMID:19019891

2. Independent control of drop size and velocity in microfluidic flow-focusing generators using variable temperature and flow rate.

PubMed

Stan, Claudiu A; Tang, Sindy K Y; Whitesides, George M

2009-03-15

This paper describes a method to control the volume and the velocity of drops generated in a flow-focusing device dynamically and independently. This method involves simultaneous tuning of the temperature of the nozzle of the device and of the flow rate of the continuous phase; the method requires a continuous phase liquid that has a viscosity that varies steeply with temperature. Increasing the temperature of the flow-focusing nozzle from 0 to 80 degrees C increased the volume of the drops by almost 2 orders of magnitude. Tuning both the temperature and the flow rate controlled the drop volume and the drop velocity independently; this feature is not possible in a basic flow-focusing device. This paper also demonstrates a procedure for identifying the range of possible drop volumes and drop velocities for a given flow-focusing device and shows how to generate drops with a specified volume and velocity within this range. This method is easy to implement in on-chip applications where thermal management is already incorporated in the system, such as DNA amplification using the polymerase chain reaction and nanoparticle synthesis.

3. Multiple Independent Retroelement Insertions in the Promoter of a Stress Response Gene Have Variable Molecular and Functional Effects in Drosophila

PubMed Central

Merenciano, Miriam; Ullastres, Anna; González, Josefa

2016-01-01

Promoters are structurally and functionally diverse gene regulatory regions. The presence or absence of sequence motifs and the spacing between the motifs defines the properties of promoters. Recent alternative promoter usage analyses in Drosophila melanogaster revealed that transposable elements significantly contribute to promote diversity. In this work, we analyzed in detail one of the transposable element insertions, named FBti0019985, that has been co-opted to drive expression of CG18446, a candidate stress response gene. We analyzed strains from different natural populations and we found that besides FBti0019985, there are another eight independent transposable elements inserted in the proximal promoter region of CG18446. All nine insertions are solo-LTRs that belong to the roo family. We analyzed the sequence of the nine roo insertions and we investigated whether the different insertions were functionally equivalent by performing 5’-RACE, gene expression, and cold-stress survival experiments. We found that different insertions have different molecular and functional consequences. The exact position where the transposable elements are inserted matters, as they all showed highly conserved sequences but only two of the analyzed insertions provided alternative transcription start sites, and only the FBti0019985 insertion consistently affects CG18446 expression. The phenotypic consequences of the different insertions also vary: only FBti0019985 was associated with cold-stress tolerance. Interestingly, the only previous report of transposable elements inserting repeatedly and independently in a promoter region in D. melanogaster, were also located upstream of a stress response gene. Our results suggest that functional validation of individual structural variants is needed to resolve the complexity of insertion clusters. PMID:27517860

4. Dependence of P-wave dispersion on mean arterial pressure as an independent hemodynamic variable in school children

PubMed Central

González, Emilio F.; Llanes, María del Carmen; Llanes, Merlin Garí; García, Yosvany

2013-01-01

Introduction: The relationship between diastolic dysfunction and P-wave dispersion (PWD) in the electrocardiogram has been studied for some time. In this regard, echocardiography is emerging as a diagnostic tool to improve risk stratification for mild hypertension. Objective: To determine the dependence of PWD on the electrocardiogram and on echocardiographic variables in a pediatric population. Methods: 515 children from three elementary schools were studied from a total of 565 children. Those whose parents did not want them to take part in the study, as well as those with known congenital diseases, were excluded. Tests including 12-lead surface ECGs and 4 blood pressure (BP) measurements were performed. Maximum and minimum P-values were measured, and the PWD on the electrocardiogram was calculated. Echocardiography for structural measurements and the pulsed Doppler of mitral flow were also performed. Results: A significant correlation in statistical variables was found between PWD and mean BP for pre-hypertensive and hypertensive children, i.e., r = 0.32, p <0.01 and r = 0.33, p <0.01, respectively. There was a significant correlation found between PWD and the left atrial area (r = 0.45 and p <0.01). Conclusions: We highlight the dependency between PWD, the electrocardiogram and mean blood pressure. We also draw attention to the dependence of PWD on the duration of the mitral inflow A-wave. This result provides an explanation for earlier changes in atrial electrophysiological and hemodynamic characteristics in pediatric patients. PMID:24892616

5. Plant Functional Diversity Can Be Independent of Species Diversity: Observations Based on the Impact of 4-Yrs of Nitrogen and Phosphorus Additions in an Alpine Meadow.

PubMed

Li, Wei; Cheng, Ji-Min; Yu, Kai-Liang; Epstein, Howard E; Guo, Liang; Jing, Guang-Hua; Zhao, Jie; Du, Guo-Zhen

2015-01-01

Past studies have widely documented the decrease in species diversity in response to addition of nutrients, however functional diversity is often independent from species diversity. In this study, we conducted a field experiment to examine the effect of nitrogen and phosphorus fertilization ((NH4)2 HPO4) at 0, 15, 30 and 60 g m-2 yr-1 (F0, F15, F30 and F60) after 4 years of continuous fertilization on functional diversity and species diversity, and its relationship with productivity in an alpine meadow community on the Tibetan Plateau. To this purpose, three community-weighted mean trait values (specific leaf area, SLA; mature plant height, MPH; and seed size, SS) for 30 common species in each fertilization level were determined; three components of functional diversity (functional richness, FRic; functional evenness, FEve; and Rao's index of quadratic entropy, FRao) were quantified. Our results showed that: (i) species diversity sharply decreased, but functional diversity remained stable with fertilization; (ii) community-weighted mean traits (SLA and MPH) had a significant increase along the fertilization level; (iii) aboveground biomass was not correlated with functional diversity, but it was significantly correlated with species diversity and MPH. Our results suggest that decreases in species diversity due to fertilization do not result in corresponding changes in functional diversity. Functional identity of species may be more important than functional diversity in influencing aboveground productivity in this alpine meadow community, and our results also support the mass ratio hypothesis; that is, the traits of the dominant species influenced the community biomass production.

6. Plant Functional Diversity Can Be Independent of Species Diversity: Observations Based on the Impact of 4-Yrs of Nitrogen and Phosphorus Additions in an Alpine Meadow

PubMed Central

Li, Wei; Cheng, Ji-Min; Yu, Kai-Liang; Epstein, Howard E.; Guo, Liang; Jing, Guang-Hua; Zhao, Jie; Du, Guo-Zhen

2015-01-01

Past studies have widely documented the decrease in species diversity in response to addition of nutrients, however functional diversity is often independent from species diversity. In this study, we conducted a field experiment to examine the effect of nitrogen and phosphorus fertilization ((NH4)2 HPO4) at 0, 15, 30 and 60 g m-2 yr-1 (F0, F15, F30 and F60) after 4 years of continuous fertilization on functional diversity and species diversity, and its relationship with productivity in an alpine meadow community on the Tibetan Plateau. To this purpose, three community-weighted mean trait values (specific leaf area, SLA; mature plant height, MPH; and seed size, SS) for 30 common species in each fertilization level were determined; three components of functional diversity (functional richness, FRic; functional evenness, FEve; and Rao’s index of quadratic entropy, FRao) were quantified. Our results showed that: (i) species diversity sharply decreased, but functional diversity remained stable with fertilization; (ii) community-weighted mean traits (SLA and MPH) had a significant increase along the fertilization level; (iii) aboveground biomass was not correlated with functional diversity, but it was significantly correlated with species diversity and MPH. Our results suggest that decreases in species diversity due to fertilization do not result in corresponding changes in functional diversity. Functional identity of species may be more important than functional diversity in influencing aboveground productivity in this alpine meadow community, and our results also support the mass ratio hypothesis; that is, the traits of the dominant species influenced the community biomass production. PMID:26295345

7. Estimating North American background ozone in U.S. surface air with two independent global models: Variability, uncertainties, and recommendations

NASA Astrophysics Data System (ADS)

Fiore, A. M.; Oberman, J. T.; Lin, M. Y.; Zhang, L.; Clifton, O. E.; Jacob, D. J.; Naik, V.; Horowitz, L. W.; Pinto, J. P.; Milly, G. P.

2014-10-01

Accurate estimates for North American background (NAB) ozone (O3) in surface air over the United States are needed for setting and implementing an attainable national O3 standard. These estimates rely on simulations with atmospheric chemistry-transport models that set North American anthropogenic emissions to zero, and to date have relied heavily on one global model. We examine NAB estimates for spring and summer 2006 with two independent global models (GEOS-Chem and GFDL AM3). We evaluate the base simulations, which include North American anthropogenic emissions, with mid-tropospheric O3 retrieved from space and ground-level O3 measurements. The models often bracket the observed values, implying value in developing a multi-model approach to estimate NAB O3. Consistent with earlier studies, the models robustly simulate the largest nation-wide NAB levels at high-altitude western U.S. sites (seasonal average maximum daily 8-h values of ˜40-50 ppb in spring and ˜25-40 ppb in summer) where it correlates with observed O3. At these sites, a 27-year GFDL AM3 simulation simulates observed O3 events above 60 ppb and indicates that year-to-year variations in NAB O3 influence their annual frequency (with NAB contributing 50-60 ppb or more during individual events). During summer over the eastern United States (EUS), when photochemical production from regional anthropogenic emissions peaks, NAB is largely uncorrelated with observed values and it is lower than at high-altitude sites (average values of ˜20-30 ppb). Four processes contribute substantially to model differences in specific regions and seasons: lightning NOx, biogenic isoprene emissions and chemistry, wildfires, and stratosphere-to-troposphere transport. Differences in the representations of these processes within the GFDL AM3 and GEOS-Chem models contribute more to uncertainty in NAB estimates, particularly in spring when NAB is highest, than the choice of horizontal resolution within a single model (GEOS

8. Inter-participant variability in daily physical activity and sedentary time among male youth sport footballers: independent associations with indicators of adiposity and cardiorespiratory fitness.

PubMed

Fenton, Sally A M; Duda, Joan L; Barrett, Timothy

2016-01-01

Participation in youth sport is assumed to promote and contribute towards more physically active lifestyles among children and adolescents. The aim of this study was to examine inter-participant variability in objectively measured habitual physical activity (PA) behaviours and sedentary time among youth sport participants and their implications for health. One-hundred-and-eighteen male youth sport footballers (Mean ± s = 11.72 ± 1.60) wore a GT3X accelerometer for 7 days. Average daily PA [min · day(-1), in light (LPA), moderate (MPA), vigorous (VPA) and combined moderate-to-vigorous (MVPA)] and sedentary time were calculated. Participants' body mass index adjusted for age and sex (BMI-standard deviation score), per cent body fat (BF%), waist circumference and cardiorespiratory fitness were assessed. Results revealed that variability in daily PA behaviours and sedentary time (min · day(-1)) was associated with BMI-standard deviation score [VPA (-), MVPA (-)], BF% [sedentary time (+), VPA (-), MVPA (-)], waist circumference [sedentary time (+), LPA (-)] and cardiorespiratory fitness [sedentary time (-), MPA (+), VPA (+), MVPA (+)]. Whilst sedentary time and MVPA were not related to health outcomes independent of one another, associations with markers of adiposity and cardiorespiratory fitness were stronger for sedentary time. Sedentary time was also significantly positively related to waist circumference independent of VPA. Results demonstrate inter-participant variability in habitual PA and sedentary time among youth sport participants which holds implications for their health. Thus, promoting PA and, in particular, reducing sedentary time may contribute towards the prevention of adverse health consequences associated with a physically inactive lifestyle for children and adolescents active in the youth sport context.

9. Inaccuracy of Self-Evaluation as Additional Variable for Prediction of Students at Risk of Failing First-Year Chemistry

ERIC Educational Resources Information Center

Potgieter, Marietjie; Ackermann, Mia; Fletcher, Lizelle

2010-01-01

Early identification of students at risk of failing first-year chemistry allows timely intervention. Cognitive factors alone are insufficient predictors for success; however, non cognitive factors are usually difficult to measure. We have explored the use of demographic and performance variables, as well as the accuracy of self-evaluation as an…

10. A Mouse Variable Gene Fragment Binds to DNA Independently of the BCR Context: A Possible Role for Immature B-Cell Repertoire Establishment

PubMed Central

Maranhão, Andrea Queiroz; Costa, Maria Beatriz Walter; Guedes, Leonardo; Moraes-Vieira, Pedro Manoel; Raiol, Tainá; Brigido, Marcelo Macedo

2013-01-01

B-cell maturation occurs in several steps and requires constant stimulus for its continuing development. From the emergence of the pre-B-cell receptor, signal transduction stimulates and supports B-cell development. Current viewpoints indicate that both positive selection pressure for autoantigens and tonic signaling constitutively stimulate B-cell maturation. In this work, we tested for the presence of a putative DNA binding site in a variable gene segment in a germline configuration, independently of VDJ recombination. After a survey of the public antibody databases, we chose a single mouse heavy variable gene segment that is highly represented in anti-nucleic acid antibodies and tested it for ssDNA binding. A phage display approach was used to search for intrinsic binding to oligo deoxythymidine. The results revealed that binding to an antigen can be influenced by the use of a specific DNA binding V gene segment. Our data support the idea that some variable genes have intrinsic reactivity towards specific types of endogenous autoantigens, and this property may contribute to the establishment of the immature B-cell repertoire. PMID:24023756

11. Additional variability at the D12S391 STR locus in an Austrian population sample: sequencing data and allele distribution.

PubMed

Glock, B; Dauber, E M; Schwartz, D W; Mayr, W R

1997-12-01

The highly polymorphic STR locus D12S391 was investigated in an Austrian population sample (N = 150) by PCR-amplification, comparative detection on native and denaturing polyacrylamide gels and solid phase single stranded sequencing of three size variant alleles and several additional alleles. A total of 15 alleles, distinguishable by size under denaturing conditions, could be detected. No deviations from Hardy-Weinberg equilibrium were observed in the population investigated (P = 0.52). Sequencing of size variants designated 17.3 and 18.3 showed an incomplete (GAT) repeat unit at position two of the tandem region. Additional new sequence variants due to varying compositions of the number of (AGAT) and (AGAC) repeats could be identified. Due to distinct electrophoretical mobilities of alleles of the same size but different sequence structures, denaturing detection conditions should be employed when the aim is standardization.

12. Independent Contributions of the Central Executive, Intelligence, and In-Class Attentive Behavior to Developmental Change in the Strategies Used to Solve Addition Problems

ERIC Educational Resources Information Center

Geary, David C.; Hoard, Mary K.; Nugent, Lara

2012-01-01

Children's (N = 275) use of retrieval, decomposition (e.g., 7 = 4+3 and thus 6+7 = 6+4+3), and counting to solve additional problems was longitudinally assessed from first grade to fourth grade, and intelligence, working memory, and in-class attentive behavior was assessed in one or several grades. The goal was to assess the relation between…

13. High-level exogenous glutamic acid-independent production of poly-(γ-glutamic acid) with organic acid addition in a new isolated Bacillus subtilis C10.

PubMed

Zhang, Huili; Zhu, Jianzhong; Zhu, Xiangcheng; Cai, Jin; Zhang, Anyi; Hong, Yizhi; Huang, Jin; Huang, Lei; Xu, Zhinan

2012-07-01

A new exogenous glutamic acid-independent γ-PGA producing strain was isolated and characterized as Bacillus subtilis C10. The factors influencing the endogenous glutamic acid supply and the biosynthesis of γ-PGA in this strain were investigated. The results indicated that citric acid and oxalic acid showed the significant capability to support the overproduction of γ-PGA. This stimulated increase of γ-PGA biosynthesis by citric acid or oxalic acid was further proved in the 10 L fermentor. To understand the possible mechanism contributing to the improved γ-PGA production, the activities of four key intracellular enzymes were measured, and the possible carbon fluxes were proposed. The result indicated that the enhanced level of pyruvate dehydrogenase (PDH) activity caused by oxalic acid was important for glutamic acid synthesized de novo from glucose. Moreover, isocitrate dehydrogenase (ICDH) and glutamate dehydrogenase (GDH) were the positive regulators of glutamic acid biosynthesis, while 2-oxoglutarate dehydrogenase complex (ODHC) was the negative one.

14. Twelve-Month Prostate-Specific Antigen Values and Perineural Invasion as Strong Independent Prognostic Variables of Long-Term Biochemical Outcome After Prostate Seed Brachytherapy

SciTech Connect

Ding, William; Lee, John; Chamberlain, David; Cunningham, James; Yang Lixi; Tay, Jonathan

2012-11-15

Purpose: To determine whether post-treatment prostate-specific antigen (ptPSA) values at 12 months and other clinical parameters predict long-term PSA relapse-free survival (PRFS) following prostate seed brachytherapy. Methods and Materials: Records of 204 hormone-naieve patients with localized adenocarcinoma of the prostate treated at St. Mary's Regional Medical Center in Reno, NV, and at Carson Tahoe Regional Medical Center in Carson City, NV, between 1998 and 2003, using I-125 or Pd-103 seed brachytherapy, were retrospectively analyzed. Treatment planning was done using a preplanned, modified peripheral loading technique. A total of 185 of 204 patients had PSA records at 12 months after implant. Variables included were age, initial pretreatment PSA, Gleason score, T stage, National Comprehensive Cancer Network (NCCN) risk group (RG), perineural invasion (PNI), external beam boost, dose, and ptPSA levels at 12 months with cutpoints at {<=}1, 1.01 to 2.00, 2.01 to 3.00, and >3.00 ng/ml. Results: Median follow-up was 80 months, and median age was 69 years. The numbers of patients stratified by NCCN low, intermediate, and high RG were 110:65:10, respectively. Monotherapy and boost prescription doses were 145 Gy and 110 Gy for I-125, and 125 Gy and 100 Gy for Pd-103 seeds, respectively. The median dose (D90) was 95.4% of the prescribed dose. The 5-year PRFS at the 12-months ptPSA levels of {<=}1, 1.01 to 2.00, 2.01 to 3.00, and >3.00 ng/ml were 98.5%, 85.7%, 61.5%, and 22.2%, respectively. The 10-year PRFS at the 12-months ptPSA levels of {<=}1 and 1.01 to 2.00 ng/ml were 90.5% and 85.7%, respectively. In multivariate analysis, both ptPSA and PNI were significant independent predictors of PRFS. Hazard ratios (HR) for ptPSA levels at {<=}1, 1.01 to 2.00, 2.01 to 3.00, and >3.00 ng/ml at 12 months were 1, 4.96, 27.57, and 65.10, respectively. PNI had an HR of 6.1 (p = 0.009). Conclusions: Presence of PNI and ptPSA values at 12 months are strong prognostic variables for

15. Variability in Ozone in the Tropical Upper Troposphere-Lower Stratosphere from the 1998 - 200 SHADOZ (Southern Hemisphere ADditional Ozonesondes) Data

NASA Astrophysics Data System (ADS)

Thompson, A.; Witte, J.; Oltmans, S.; Coetzee, G.; Kawakami, S.; Ogawa, T.

The first view of lower stratospheric and upper tropospheric structure from sondes is provided by a 3 year, 10-site record from the Southern Hemisphere ADditional- OZonesondes (SHADOZ) network: . Observations covering 1998-2000 were made over Ascension Island; Nairobi, Kenya; Irene, South Africa; Reunion Island; Watukosek, Java; Fiji; Tahiti; American Samoa; San Crist"bal, Galapagos; Natal, Brazil. Taking the UT/LS (upper troposphere-lower stratosphere) as the region between 12 and 17 km, we examine ozone variability in this region on a week- to- week and seasonal basis. The tropopause is lower in September-October-November than in March-April- May, when ozone is a minimum at most SHADOZ stations. A zonal wave-one pattern (referring to ozone mixing ratios greater over the Atlantic and adjacent continents than over the Pacific and eastern Indian Ocean), persists all year. The wave, predominantly in the troposphere and with variable magnitude, appears to be due to general circulation - with subsidence over the Atlantic and frequent deep convection over the Pacific and Indian Ocean. The variability of deep convection - most prominent at Java, Fiji, Samoa and Natal - is explored in time-vs-altitude ozone curtains. Stratospheric incursions into the troposphere are most prominent in soundings at Irene and Reunion Island.

16. Variability in Ozone in the Tropical Upper Troposphere-Lower Stratosphere from the 1998-2000 SHADOZ (Southern Hemisphere Additional Ozonesondes) Data

NASA Technical Reports Server (NTRS)

Thompson, A. M.; Witte, J. C.; McPeters, R. D.; Schmidlin, F. J.; Oltmans, S. J.; Kirchhoff, V. W. J. H.; Coetzee, G. J. R.; Posny, F.; Kawakami, S.; Ogawa, T.; Bhartia, P. K. (Technical Monitor)

2002-01-01

The first view of lower stratospheric and upper tropospheric structure from sondes is provided by a 3-year, 10-site record from the Southern Hemisphere ADditional OZonesondes (SHADOZ) network: . Observations covering 1998-2000 were made over Ascension Island; Nairobi, Kenya; Irene, South Africa; Reunion Island; Watukosek, Java; Fiji; Tahiti; American Samoa; San Cristobal, Galapagos; Natal, Brazil. Taking the UT/LS (upper troposphere- lower stratosphere) as the region between 12 and 17 km, we examine ozone variability in this region on a week-to-week and seasonal basis. The tropopause is lower in September-October-November than in March-April-May, when ozone is a minimum at most SHADOZ stations. A zonal wave-one pattern (referring to ozone mixing ratios greater over the Atlantic and adjacent continents than over the Pacific and eastern Indian Ocean), persists all year. The wave, predominantly in the troposphere and with variable magnitude, appears to be due to general circulation - with subsidence over the Atlantic and frequent deep convection over the Pacific and Indian Ocean. The variability of deep convection most prominent at Java, Fiji, Samoa and Natal - is explored in time-vs-altitude ozone curtains. Stratospheric incursions into the troposphere are most prominent in soundings at Irene and Reunion Island.

17. Fused Lasso Additive Model

PubMed Central

Petersen, Ashley; Witten, Daniela; Simon, Noah

2016-01-01

We consider the problem of predicting an outcome variable using p covariates that are measured on n independent observations, in a setting in which additive, flexible, and interpretable fits are desired. We propose the fused lasso additive model (FLAM), in which each additive function is estimated to be piecewise constant with a small number of adaptively-chosen knots. FLAM is the solution to a convex optimization problem, for which a simple algorithm with guaranteed convergence to a global optimum is provided. FLAM is shown to be consistent in high dimensions, and an unbiased estimator of its degrees of freedom is proposed. We evaluate the performance of FLAM in a simulation study and on two data sets. Supplemental materials are available online, and the R package flam is available on CRAN. PMID:28239246

18. The 1998-2000 SHADOZ (Southern Hemisphere ADditional OZonesondes) Tropical Ozone Climatology: Ozonesonde Precision, Accuracy and Station-to-Station Variability

NASA Technical Reports Server (NTRS)

Witte, J. C.; Thompson, Anne M.; McPeters, R. D.; Oltmans, S. J.; Schmidlin, F. J.; Bhartia, P. K. (Technical Monitor)

2001-01-01

As part of the SAFARI-2000 campaign, additional launches of ozonesondes were made at Irene, South Africa and at Lusaka, Zambia. These represent campaign augmentations to the SHADOZ database described in this paper. This network of 10 southern hemisphere tropical and subtropical stations, designated the Southern Hemisphere ADditional OZonesondes (SHADOZ) project and established from operational sites, provided over 1000 profiles from ozonesondes and radiosondes during the period 1998-2000. (Since that time, two more stations, one in southern Africa, have joined SHADOZ). Archived data are available at: http://code9l6.gsfc.nasa.gov/Data-services/shadoz>. Uncertainties and accuracies within the SHADOZ ozone data set are evaluated by analyzing: (1) imprecisions in stratospheric ozone profiles and in methods of extrapolating ozone above balloon burst; (2) comparisons of column-integrated total ozone from sondes with total ozone from the Earth-Probe/TOMS (Total Ozone Mapping Spectrometer) satellite and ground-based instruments; (3) possible biases from station-to-station due to variations in ozonesonde characteristics. The key results are: (1) Ozonesonde precision is 5%; (2) Integrated total ozone column amounts from the sondes are in good agreement (2-10%) with independent measurements from ground-based instruments at five SHADOZ sites and with overpass measurements from the TOMS satellite (version 7 data). (3) Systematic variations in TOMS-sonde offsets and in groundbased-sonde offsets from station to station reflect biases in sonde technique as well as in satellite retrieval. Discrepancies are present in both stratospheric and tropospheric ozone. (4) There is evidence for a zonal wave-one pattern in total and tropospheric ozone, but not in stratospheric ozone.

19. The influence of environmental variables on the presence of white sharks, Carcharodon carcharias at two popular Cape Town bathing beaches: a generalized additive mixed model.

PubMed

Weltz, Kay; Kock, Alison A; Winker, Henning; Attwood, Colin; Sikweyiya, Monwabisi

2013-01-01

Shark attacks on humans are high profile events which can significantly influence policies related to the coastal zone. A shark warning system in South Africa, Shark Spotters, recorded 378 white shark (Carcharodon carcharias) sightings at two popular beaches, Fish Hoek and Muizenberg, during 3690 six-hour long spotting shifts, during the months September to May 2006 to 2011. The probabilities of shark sightings were related to environmental variables using Binomial Generalized Additive Mixed Models (GAMMs). Sea surface temperature was significant, with the probability of shark sightings increasing rapidly as SST exceeded 14 °C and approached a maximum at 18 °C, whereafter it remains high. An 8 times (Muizenberg) and 5 times (Fish Hoek) greater likelihood of sighting a shark was predicted at 18 °C than at 14 °C. Lunar phase was also significant with a prediction of 1.5 times (Muizenberg) and 4 times (Fish Hoek) greater likelihood of a shark sighting at new moon than at full moon. At Fish Hoek, the probability of sighting a shark was 1.6 times higher during the afternoon shift compared to the morning shift, but no diel effect was found at Muizenberg. A significant increase in the number of shark sightings was identified over the last three years, highlighting the need for ongoing research into shark attack mitigation. These patterns will be incorporated into shark awareness and bather safety campaigns in Cape Town.

20. The 1998-2000 SHADOZ (Southern Hemisphere ADditional OZonesondes) Tropical Ozone Climatology. 2; Stratospheric and Tropospheric Ozone Variability and the Zonal Wave-One

NASA Technical Reports Server (NTRS)

Thompson, Anne M.; Witte, Jacquelyn C.; Oltmans, Samuel J.; Schmidlin, Francis J.; Logan, Jennifer A.; Fujiwara, Masatomo; Kirchhoff, Volker W. J. H.; Posny, Francoise; Coetzee, Gert J. R.; Hoegger, Bruno; Bhartia, P. K. (Technical Monitor)

2002-01-01

This is the second 'reference' or 'archival' paper for the SHADOZ (Southern Hemisphere Additional Ozonesondes) network and is a follow-on to the recently accepted paper with similar first part of title. The latter paper compared SHADOZ total ozone with satellite and ground-based instruments and showed that the equatorial wave-one in total ozone is in the troposphere. The current paper presents details of the wave-one structure and the first overview of tropospheric ozone variability over the southern Atlantic, Pacific and Indian Ocean basins. The principal new result is that signals of climate effects, convection and offsets between biomass burning seasonality and tropospheric ozone maxima suggest that dynamical factors are perhaps more important than pollution in determining the tropical distribution of tropospheric ozone. The SHADOZ data at () are setting records in website visits and are the first time that the zonal view of tropical ozone structure has been recorded - thanks to the distribution of the 10 sites that make up this validation network.

1. Are Independent Probes Truly Independent?

ERIC Educational Resources Information Center

Camp, Gino; Pecher, Diane; Schmidt, Henk G.; Zeelenberg, Rene

2009-01-01

The independent cue technique has been developed to test traditional interference theories against inhibition theories of forgetting. In the present study, the authors tested the critical criterion for the independence of independent cues: Studied cues not presented during test (and unrelated to test cues) should not contribute to the retrieval…

2. Optimization of medium components and cultural variables for enhanced production of acidic high maltose-forming and Ca2+-independent α-amylase by Bacillus acidicola.

PubMed

Sharma, Archana; Satyanarayana, Tulasi

2011-05-01

The production of acidic α-amylase by a novel acidophilic bacterium Bacillus acidicola TSAS1 was optimized in submerged fermentation using statistical approaches. The process parameters that significantly affected α-amylase production (starch, K(2)HPO(4), inoculum size and temperature) were identified by Plackett and Burman design. The optimum levels of the significant variables as determined using central composite design of response surface methodology are starch (2.75%), K(2)HPO(4) (0.01%), inoculum size [2% (v/v) containing 1.9×10(8) CFU ml(-1)], and temperature (33°C). An overall 2.4 and 2.9-fold increase in enzyme production has been attained in batch and fed-batch fermentations in the laboratory fermentor, respectively.

3. Salam's independence

NASA Astrophysics Data System (ADS)

Fraser, Gordon

2009-01-01

In his kind review of my biography of the Nobel laureate Abdus Salam (December 2008 pp45-46), John W Moffat wrongly claims that Salam had "independently thought of the idea of parity violation in weak interactions".

4. N-tuple topological/geometric cutoffs for 3D N-linear algebraic molecular codifications: variability, linear independence and QSAR analysis.

PubMed

García-Jacas, C R; Marrero-Ponce, Y; Barigye, S J; Hernández-Ortega, T; Cabrera-Leyva, L; Fernández-Castillo, A

2016-12-01

Novel N-tuple topological/geometric cutoffs to consider specific inter-atomic relations in the QuBiLS-MIDAS framework are introduced in this manuscript. These molecular cutoffs permit the taking into account of relations between more than two atoms by using (dis-)similarity multi-metrics and the concepts related with topological and Euclidean-geometric distances. To this end, the kth two-, three- and four-tuple topological and geometric neighbourhood quotient (NQ) total (or local-fragment) spatial-(dis)similarity matrices are defined, to represent 3D information corresponding to the relations between two, three and four atoms of the molecular structures that satisfy certain cutoff criteria. First, an analysis of a diverse chemical space for the most common values of topological/Euclidean-geometric distances, bond/dihedral angles, triangle/quadrilateral perimeters, triangle area and volume was performed in order to determine the intervals to take into account in the cutoff procedures. A variability analysis based on Shannon's entropy reveals that better distribution patterns are attained with the descriptors based on the cutoffs proposed (QuBiLS-MIDAS NQ-MDs) with regard to the results obtained when all inter-atomic relations are considered (QuBiLS-MIDAS KA-MDs - 'Keep All'). A principal component analysis shows that the novel molecular cutoffs codify chemical information captured by the respective QuBiLS-MIDAS KA-MDs, as well as information not captured by the latter. Lastly, a QSAR study to obtain deeper knowledge of the contribution of the proposed methods was carried out, using four molecular datasets (steroids (STER), angiotensin converting enzyme (ACE), thermolysin inhibitors (THER) and thrombin inhibitors (THR)) widely used as benchmarks in the evaluation of several methodologies. One to four variable QSAR models based on multiple linear regression were developed for each compound dataset following the original division into training and test sets. The

5. External concentration of organic acid anions and pH: key independent variables for studying how organic acids inhibit growth of bacteria in mildly acidic foods.

PubMed

Carpenter, C E; Broadbent, J R

2009-01-01

Although the mechanisms by which organic acids inhibit growth of bacteria in mildly acidic foods are not fully understood, it is clear that intracellular accumulation of anions is a primary contributor to inhibition of bacterial growth. We hypothesize that intracellular accumulation of anions is driven by 2 factors, external anion concentration and external acidity. This hypothesis follows from basic chemistry principles that heretofore have not been fully applied to studies in the field, and it has led us to develop a novel approach for predicting internal anion concentration by controlling the external concentration of anions and pH. This approach overcomes critical flaws in contemporary experimental design that invariably target concentration of either protonated acid or total acid in the growth media thereby leaving anion concentration to vary depending on the pK(a) of the acids involved. Failure to control external concentration of anions has undoubtedly confounded results, and it has likely led to misleading conclusions regarding the antimicrobial action of organic acids. In summary, we advocate an approach for directing internal anion levels by controlling external concentration of anions and pH because it presents an additional opportunity to study the mechanisms by which organic acids inhibit bacterial growth. Knowledge gained from such studies would have important application in the control of important foodborne pathogens such as Listeria monocytogenes, and may also facilitate efforts to promote the survival in foods or beverages of desirable probiotic bacteria.

6. Independent Living.

ERIC Educational Resources Information Center

Nathanson, Jeanne H., Ed.

1994-01-01

This issue of "OSERS" addresses the subject of independent living of individuals with disabilities. The issue includes a message from Judith E. Heumann, the Assistant Secretary of the Office of Special Education and Rehabilitative Services (OSERS), and 10 papers. Papers have the following titles and authors: "Changes in the…

7. Effectiveness of the Touch Math Technique in Teaching Basic Addition to Children with Autism

ERIC Educational Resources Information Center

Yikmis, Ahmet

2016-01-01

This study aims to reveal whether the touch math technique is effective in teaching basic addition to children with autism. The dependent variable of this study is the children's skills to solve addition problems correctly, whereas teaching with the touch math technique is the independent variable. Among the single-subject research models, a…

8. Understanding independence

NASA Astrophysics Data System (ADS)

Annan, James; Hargreaves, Julia

2016-04-01

In order to perform any Bayesian processing of a model ensemble, we need a prior over the ensemble members. In the case of multimodel ensembles such as CMIP, the historical approach of ``model democracy'' (i.e. equal weight for all models in the sample) is no longer credible (if it ever was) due to model duplication and inbreeding. The question of ``model independence'' is central to the question of prior weights. However, although this question has been repeatedly raised, it has not yet been satisfactorily addressed. Here I will discuss the issue of independence and present a theoretical foundation for understanding and analysing the ensemble in this context. I will also present some simple examples showing how these ideas may be applied and developed.

9. Independence test for sparse data

NASA Astrophysics Data System (ADS)

García, J. E.; González-López, V. A.

2016-06-01

In this paper a new non-parametric independence test is presented. García and González-López (2014) [1] introduced the LIS test for the hypothesis of independence between two continuous random variables, the test proposed in this work is a generalization of the LIS test. The new test does not require the assumption of continuity for the random variables, it test is applied to two datasets and also compared with the Pearson's Chi-squared test.

10. 'Independence' Panorama

NASA Technical Reports Server (NTRS)

2005-01-01

[figure removed for brevity, see original site] Click on the image for 'Independence' Panorama (QTVR)

This is the Spirit 'Independence' panorama, acquired on martian days, or sols, 536 to 543 (July 6 to 13, 2005), from a position in the 'Columbia Hills' near the summit of 'Husband Hill.' The summit of 'Husband Hill' is the peak near the right side of this panorama and is about 100 meters (328 feet) away from the rover and about 30 meters (98 feet) higher in elevation. The rocky outcrops downhill and on the left side of this mosaic include 'Larry's Lookout' and 'Cumberland Ridge,' which Spirit explored in April, May, and June of 2005.

The panorama spans 360 degrees and consists of 108 individual images, each acquired with five filters of the rover's panoramic camera. The approximate true color of the mosaic was generated using the camera's 750-, 530-, and 480-nanometer filters. During the 8 martian days, or sols, that it took to acquire this image, the lighting varied considerably, partly because of imaging at different times of sol, and partly because of small sol-to-sol variations in the dustiness of the atmosphere. These slight changes produced some image seams and rock shadows. These seams have been eliminated from the sky portion of the mosaic to better simulate the vista a person standing on Mars would see. However, it is often not possible or practical to smooth out such seams for regions of rock, soil, rover tracks or solar panels. Such is the nature of acquiring and assembling large panoramas from the rovers.

11. Ground-water monitoring plan, water quality, and variability of agricultural chemicals in the Missouri River alluvial aquifer near the City of Independence, Missouri, well field, 1998-2000

USGS Publications Warehouse

Kelly, Brian P.

2002-01-01

A detailed ground-water sampling plan was developed and executed for 64 monitoring wells in the city of Independence well field to characterize ground-water quality in the 10-year zone of contribution. Samples were collected from monitoring wells, combined Independence well field pumpage, and the Missouri River at St. Joseph, Missouri, from 1998 through 2000. In 328 ground-water samples from the 64 monitoring wells and combined well field pumpage samples, specific conductance values ranged from 511 to 1,690 microsiemens per centimeter at 25 degrees Celsius, pH values ranged from 6.4 to 7.7, water temperature ranged from 11.3 to 23.6 degrees Celsius, and dissolved oxygen concentrations ranged from 0 to 3.3 milligrams per liter. In 12 samples from the combined well field pumpage samples, specific conductance values ranged from 558 to 856 microsiemens per centimeter at 25 degrees Celsius, pH values ranged from 6.9 to 7.7, water temperature ranged from 5.8 to 22.9 degrees Celsius, and dissolved oxygen concentrations ranged from 0 to 2.4 milligrams per liter. In 45 Missouri River samples, specific conductance values ranged from 531 to 830 microsiemens per centimeter at 25 degrees Celsius, pH ranged from 7.2 to 8.7, water temperature ranged from 0 to 30 degrees Celsius, and dissolved oxygen concentrations ranged from 5.0 to 17.6 milligrams per liter. The secondary maximum contaminant level for sulfate in drinking water was exceeded once in samples from two monitoring wells, the maximum contaminant level (MCL) for antimony was exceeded once in a sample from one monitoring well, and the MCL for barium was exceeded once in a sample from one monitoring well. The MCL for iron was exceeded in samples from all monitoring wells except two. The MCL for manganese was exceeded in all samples from monitoring wells and combined well field pumpage. Enzyme linked immunoassay methods indicate total benzene, toluene, ethyl benzene, and xylene (BTEX) was detected in samples from five

PubMed Central

Spencer, Michael

1974-01-01

Food additives are discussed from the food technology point of view. The reasons for their use are summarized: (1) to protect food from chemical and microbiological attack; (2) to even out seasonal supplies; (3) to improve their eating quality; (4) to improve their nutritional value. The various types of food additives are considered, e.g. colours, flavours, emulsifiers, bread and flour additives, preservatives, and nutritional additives. The paper concludes with consideration of those circumstances in which the use of additives is (a) justified and (b) unjustified. PMID:4467857

13. A survey for faint variable objects in SA 57

SciTech Connect

Trevese, D.; Pittella, G.; Kron, R.G.; Koo, D.C.; Bershady, M.; Roma, Osservatorio Astronomico; ESA, European Space Research Institute, Frascati; Yerkes Observatory, Williams Bay, WI; Space Telescope Science Institute, Baltimore, MD; Lick Observatory, Santa Cruz, CA; Chicago Univ., IL )

1989-07-01

Nine Mayall 4 m prime-focus Kodak IIIa-J plates spanning an 11-yr baseline are analyzed in a uniform manner for the detection of variable objects to B = 22.6 at the level of Sigma of about 0.1 mag. Techniques are developed that succeed in independently finding objects already known to be variable, namely a sample of QSOs. Few additional objects were identified as variables with high certainty. The principal result, therefore, is an upper limit both to variable QSOs not previously identified by other techniques, and an upper limit at faint magnitudes on other classes of variable objects. 21 refs.

MedlinePlus

... or natural. Natural food additives include: Herbs or spices to add flavor to foods Vinegar for pickling ... Certain colors improve the appearance of foods. Many spices, as well as natural and man-made flavors, ...

15. The combined inhibitory effect of the adenosine A1 and cannabinoid CB1 receptors on cAMP accumulation in the hippocampus is additive and independent of A1 receptor desensitization.

PubMed

Serpa, André; Correia, Sara; Ribeiro, Joaquim A; Sebastião, Ana M; Cascalheira, José F

2015-01-01

Adenosine A1 and cannabinoid CB1 receptors are highly expressed in hippocampus where they trigger similar transduction pathways. We investigated how the combined acute activation of A1 and CB1 receptors modulates cAMP accumulation in rat hippocampal slices. The CB1 agonist WIN55212-2 (0.3-30 μM) decreased forskolin-stimulated cAMP accumulation with an EC50 of 6.6±2.7 μM and an Emax of 31%±2%, whereas for the A1 agonist, N6-cyclopentyladenosine (CPA, 10-150 nM), an EC50 of 35±19 nM, and an Emax of 29%±5 were obtained. The combined inhibitory effect of WIN55212-2 (30 μM) and CPA (100 nM) on cAMP accumulation was 41%±6% (n=4), which did not differ (P>0.7) from the sum of the individual effects of each agonist (43%±8%) but was different (P<0.05) from the effects of CPA or WIN55212-2 alone. Preincubation with CPA (100 nM) for 95 min caused desensitization of adenosine A1 activity, which did not modify the effect of WIN55212-2 (30 μM) on cAMP accumulation. In conclusion, the combined effect of CB1 and A1 receptors on cAMP formation is additive and CB1 receptor activity is not affected by short-term A1 receptor desensitization.

SciTech Connect

Rudolf Keller

2004-08-10

In this project, a concept to improve the performance of aluminum production cells by introducing potlining additives was examined and tested. Boron oxide was added to cathode blocks, and titanium was dissolved in the metal pool; this resulted in the formation of titanium diboride and caused the molten aluminum to wet the carbonaceous cathode surface. Such wetting reportedly leads to operational improvements and extended cell life. In addition, boron oxide suppresses cyanide formation. This final report presents and discusses the results of this project. Substantial economic benefits for the practical implementation of the technology are projected, especially for modern cells with graphitized blocks. For example, with an energy savings of about 5% and an increase in pot life from 1500 to 2500 days, a cost savings of \$ 0.023 per pound of aluminum produced is projected for a 200 kA pot.

DOEpatents

Harrup, Mason K; Rollins, Harry W

2013-11-26

An additive comprising a phosphazene compound that has at least two reactive functional groups and at least one capping functional group bonded to phosphorus atoms of the phosphazene compound. One of the at least two reactive functional groups is configured to react with cellulose and the other of the at least two reactive functional groups is configured to react with a resin, such as an amine resin of a polycarboxylic acid resin. The at least one capping functional group is selected from the group consisting of a short chain ether group, an alkoxy group, or an aryloxy group. Also disclosed are an additive-resin admixture, a method of treating a wood product, and a wood product.

18. Analyzing consistency of independent components: an fMRI illustration.

PubMed

Ylipaavalniemi, Jarkko; Vigário, Ricardo

2008-01-01

Independent component analysis (ICA) is a powerful data-driven signal processing technique. It has proved to be helpful in, e.g., biomedicine, telecommunication, finance and machine vision. Yet, some problems persist in its wider use. One concern is the reliability of solutions found with ICA algorithms, resulting from the stochastic changes each time the analysis is performed. The consistency of the solutions can be analyzed by clustering solutions from multiple runs of bootstrapped ICA. Related methods have been recently published either for analyzing algorithmic stability or reducing the variability. The presented approach targets the extraction of additional information related to the independent components, by focusing on the nature of the variability. Practical implications are illustrated through a functional magnetic resonance imaging (fMRI) experiment.

19. Independent Peer Reviews

SciTech Connect

2012-03-16

Independent Assessments: DOE's Systems Integrator convenes independent technical reviews to gauge progress toward meeting specific technical targets and to provide technical information necessary for key decisions.

20. Clinical and acoustical variability in hypokinetic dysarthria

SciTech Connect

Metter, E.J.; Hanson, W.R.

1986-10-01

Ten male patients with parkinsonism secondary to Parkinson's disease or progressive supranuclear palsy had clinical neurological, speech, and acoustical speech evaluations. In addition, seven of the patients were evaluated by x-ray computed tomography (CT) and (F-18)-fluorodeoxyglucose (FDG) positron emission tomography (PET). Extensive variability of speech features, both clinical and acoustical, were found and seemed to be independent of the severity of any parkinsonian sign, CT, or FDG PET. In addition, little relationship existed between the variability across each measured speech feature. What appeared to be important for the appearance of abnormal acoustic measures was the degree of overall severity of the dysarthria. These observations suggest that a better understanding of hypokinetic dysarthria may result from more extensive examination of the variability between patients. Emphasizing a specific feature such as rapid speaking rate in characterizing hypokinetic dysarthria focuses on a single and inconstant finding in a complex speech pattern.

1. Group Sparse Additive Models

PubMed Central

Yin, Junming; Chen, Xi; Xing, Eric P.

2016-01-01

We consider the problem of sparse variable selection in nonparametric additive models, with the prior knowledge of the structure among the covariates to encourage those variables within a group to be selected jointly. Previous works either study the group sparsity in the parametric setting (e.g., group lasso), or address the problem in the nonparametric setting without exploiting the structural information (e.g., sparse additive models). In this paper, we present a new method, called group sparse additive models (GroupSpAM), which can handle group sparsity in additive models. We generalize the ℓ1/ℓ2 norm to Hilbert spaces as the sparsity-inducing penalty in GroupSpAM. Moreover, we derive a novel thresholding condition for identifying the functional sparsity at the group level, and propose an efficient block coordinate descent algorithm for constructing the estimate. We demonstrate by simulation that GroupSpAM substantially outperforms the competing methods in terms of support recovery and prediction accuracy in additive models, and also conduct a comparative experiment on a real breast cancer dataset.

2. Altered muscle coordination when pedaling with independent cranks

PubMed Central

Hug, François; Boumier, Florian; Dorel, Sylvain

2013-01-01

Pedaling with independent cranks ensures each leg cycles independently of the other, and thus eliminates the contribution of the contralateral leg during the upstroke phase. Consequently the subject is required to actively pull-up the pedal to complete the cycle. The present study aimed to determine the acute effect of the use of independent cranks on muscle coordination during a submaximal pedaling exercise. Ten healthy males were asked to perform submaximal pedaling exercises at 100 Watts with normal fixed cranks (control condition) or independent cranks. Both 2-D pedal forces and electromyographic (EMG) SIGNALS of 10 lower limb muscles were recorded. When the mean EMG activity across the cycle was considered, the use of independent cranks significantly increased the activity level compared to control for Tibialis anterior (TA) (P = 0.0017; +336 ± 302%), Gastrocnemius medialis (GM) (P = 0.0005; +47 ± 25%), Rectus femoris (RF) (P = 0.005; +123 ± 153%), Biceps femoris (BF)—long head (P = 0.0001; +162 ± 97%), Semimembranosus (SM) (P = 0.0001; +304 ± 192%), and Tensor fascia latae (P = 0.0001; +586 ± 262%). The analysis of the four pedaling sectors revealed that the increased activity of hip and knee flexors mainly occurred during the top dead center and the upstroke phase. In addition, a high inter-individual variability was found in the way the participants adapted to pedaling with independent cranks. The present results showed that the enforced pull-up action required when using independent cranks was achieved by increasing the activation of hip and knee flexors. Further studies are needed to determine whether training with independent cranks has the potential to induce long-term changes in muscle coordination, and, if so, whether these changes are beneficial for cycling performance. PMID:24009587

3. Altered muscle coordination when pedaling with independent cranks.

PubMed

Hug, François; Boumier, Florian; Dorel, Sylvain

2013-01-01

Pedaling with independent cranks ensures each leg cycles independently of the other, and thus eliminates the contribution of the contralateral leg during the upstroke phase. Consequently the subject is required to actively pull-up the pedal to complete the cycle. The present study aimed to determine the acute effect of the use of independent cranks on muscle coordination during a submaximal pedaling exercise. Ten healthy males were asked to perform submaximal pedaling exercises at 100 Watts with normal fixed cranks (control condition) or independent cranks. Both 2-D pedal forces and electromyographic (EMG) SIGNALS of 10 lower limb muscles were recorded. When the mean EMG activity across the cycle was considered, the use of independent cranks significantly increased the activity level compared to control for Tibialis anterior (TA) (P = 0.0017; +336 ± 302%), Gastrocnemius medialis (GM) (P = 0.0005; +47 ± 25%), Rectus femoris (RF) (P = 0.005; +123 ± 153%), Biceps femoris (BF)-long head (P = 0.0001; +162 ± 97%), Semimembranosus (SM) (P = 0.0001; +304 ± 192%), and Tensor fascia latae (P = 0.0001; +586 ± 262%). The analysis of the four pedaling sectors revealed that the increased activity of hip and knee flexors mainly occurred during the top dead center and the upstroke phase. In addition, a high inter-individual variability was found in the way the participants adapted to pedaling with independent cranks. The present results showed that the enforced pull-up action required when using independent cranks was achieved by increasing the activation of hip and knee flexors. Further studies are needed to determine whether training with independent cranks has the potential to induce long-term changes in muscle coordination, and, if so, whether these changes are beneficial for cycling performance.

4. Independent Study in Iowa.

ERIC Educational Resources Information Center

Idaho Univ., Moscow.

This guide to independent study in Idaho begins with introductory information on the following aspects of independent study: the Independent Study in Idaho consortium, student eligibility, special needs, starting dates, registration, costs, textbooks and instructional materials, e-mail and faxing, refunds, choosing a course, time limits, speed…

5. An Approach to Keeping Independent Colleges Independent.

ERIC Educational Resources Information Center

Northwest Area Foundation, St. Paul, Minn.

As a result of the financial difficulties faced by independent colleges in the northwestern United States, the Northwest Area Foundation in 1972 surveyed the administrations of 80 private colleges to get a profile of the colleges, a list of their current problems, and some indication of how the problems might be approached. The three top problems…

6. Spatial Variance in Resting fMRI Networks of Schizophrenia Patients: An Independent Vector Analysis.

PubMed

Gopal, Shruti; Miller, Robyn L; Michael, Andrew; Adali, Tulay; Cetin, Mustafa; Rachakonda, Srinivas; Bustillo, Juan R; Cahill, Nathan; Baum, Stefi A; Calhoun, Vince D

2016-01-01

Spatial variability in resting functional MRI (fMRI) brain networks has not been well studied in schizophrenia, a disease known for both neurodevelopmental and widespread anatomic changes. Motivated by abundant evidence of neuroanatomical variability from previous studies of schizophrenia, we draw upon a relatively new approach called independent vector analysis (IVA) to assess this variability in resting fMRI networks. IVA is a blind-source separation algorithm, which segregates fMRI data into temporally coherent but spatially independent networks and has been shown to be especially good at capturing spatial variability among subjects in the extracted networks. We introduce several new ways to quantify differences in variability of IVA-derived networks between schizophrenia patients (SZs = 82) and healthy controls (HCs = 89). Voxelwise amplitude analyses showed significant group differences in the spatial maps of auditory cortex, the basal ganglia, the sensorimotor network, and visual cortex. Tests for differences (HC-SZ) in the spatial variability maps suggest, that at rest, SZs exhibit more activity within externally focused sensory and integrative network and less activity in the default mode network thought to be related to internal reflection. Additionally, tests for difference of variance between groups further emphasize that SZs exhibit greater network variability. These results, consistent with our prediction of increased spatial variability within SZs, enhance our understanding of the disease and suggest that it is not just the amplitude of connectivity that is different in schizophrenia, but also the consistency in spatial connectivity patterns across subjects.

7. Prospects for an Independent Kurdistan

DTIC Science & Technology

2008-03-01

are mostly Sunni.25 In addition, about 5 percent of the Kurds are Yazidis, which is a “mixture of Islamic, Christian , Jewish, and pagan beliefs...significant political progress has been made by the Kurds of Iraq. The probability of ongoing ethnic and religious strife within Iraq creates an...seek independence. Figure 2 shows the ethno- religious 38 “Guide to Iraqi political parties,” BBC News, http://news.bbc.co.uk

8. Testing for conditional multiple marginal independence.

PubMed

Bilder, Christopher R; Loughin, Thomas M

2002-03-01

Survey respondents are often prompted to pick any number of responses from a set of possible responses. Categorical variables that summarize this kind of data are called pick any/c variables. Counts from surveys that contain a pick any/c variable along with a group variable (r levels) and stratification variable (q levels) can be marginally summarized into an r x c x q contingency table. A question that may naturally arise from this setup is to determine if the group and pick any/c variable are marginally independent given the stratification variable. A test for conditional multiple marginal independence (CMMI) can be used to answer this question. Since subjects may pick any number out of c possible responses, the Cochran (1954, Biometrics 10, 417-451) and Mantel and Haenszel (1959, Journal of the National Cancer Institute 22, 719-748) tests cannot be used directly because they assume that units in the contingency table are independent of each other. Therefore, new testing methods are developed. Cochran's test statistic is extended to r x 2 x q tables, and a modified version of this statistic is proposed to test CMMI. Its sampling distribution can be approximated through bootstrapping. Other CMMI testing methods discussed are bootstrap p-value combination methods and Bonferroni adjustments. Simulation findings suggest that the proposed bootstrap procedures and the Bonferroni adjustments consistently hold the correct size and provide power against various alternatives.

9. American Independence. Fifth Grade.

ERIC Educational Resources Information Center

Crosby, Annette

This fifth grade teaching unit covers early conflicts between the American colonies and Britain, battles of the American Revolutionary War, and the Declaration of Independence. Knowledge goals address the pre-revolutionary acts enforced by the British, the concepts of conflict and independence, and the major events and significant people from the…

10. Independence of Internal Auditors.

ERIC Educational Resources Information Center

Montondon, Lucille; Meixner, Wilda F.

1993-01-01

A survey of 288 college and university auditors investigated patterns in their appointment, reporting, and supervisory practices as indicators of independence and objectivity. Results indicate a weakness in the positioning of internal auditing within institutions, possibly compromising auditor independence. Because the auditing function is…

11. Reconciling catch differences from multiple fishery independent gill net surveys

USGS Publications Warehouse

Kraus, Richard T.; Vandergoot, Christopher; Kocovsky, Patrick M.; Rogers, Mark W.; Cook, H. Andrew; Brenden, Travis O.

2017-01-01

Fishery independent gill net surveys provide valuable demographic information for population assessment and resource management, but relative to net construction, the effects of ancillary species, and environmental variables on focal species catch rates are poorly understood. In response, we conducted comparative deployments with three unique, inter-agency, survey gill nets used to assess walleye Sander vitreus in Lake Erie. We used an information-theoretic approach with Akaike’s second-order information criterion (AICc) to evaluate linear mixed models of walleye catch as a function of net type (multifilament and two types of monofilament netting), mesh size (categorical), Secchi depth, temperature, water depth, catch of ancillary species, and interactions among selected variables. The model with the greatest weight of evidence showed that walleye catches were positively associated with potential prey and intra-guild predators and negatively associated with water depth and temperature. In addition, the multifilament net had higher average walleye catches than either of the two monofilament nets. Results from this study both help inform decisions about proposed gear changes to stock assessment surveys in Lake Erie, and advance our understanding of how multispecies associations explain variation in gill net catches. Of broader interest to fishery-independent gill net studies, effects of abiotic variables and ancillary species on focal specie’s catch rates were small in comparison with net characteristics of mesh size or twine type.

12. Charter School Parents and Their Perceptions of Independent Schools

ERIC Educational Resources Information Center

2014-01-01

Given that independent schools have started to face competition from charter schools, the National Association of Independent Schools (NAIS) commissioned a study with current and prospective charter school parents to determine their perceptions of charter vs. independent schools, assess the relative impact of the variables that affect their school…

13. Chandra Independently Determines Hubble Constant

NASA Astrophysics Data System (ADS)

2006-08-01

A critically important number that specifies the expansion rate of the Universe, the so-called Hubble constant, has been independently determined using NASA's Chandra X-ray Observatory. This new value matches recent measurements using other methods and extends their validity to greater distances, thus allowing astronomers to probe earlier epochs in the evolution of the Universe. "The reason this result is so significant is that we need the Hubble constant to tell us the size of the Universe, its age, and how much matter it contains," said Max Bonamente from the University of Alabama in Huntsville and NASA's Marshall Space Flight Center (MSFC) in Huntsville, Ala., lead author on the paper describing the results. "Astronomers absolutely need to trust this number because we use it for countless calculations." Illustration of Sunyaev-Zeldovich Effect Illustration of Sunyaev-Zeldovich Effect The Hubble constant is calculated by measuring the speed at which objects are moving away from us and dividing by their distance. Most of the previous attempts to determine the Hubble constant have involved using a multi-step, or distance ladder, approach in which the distance to nearby galaxies is used as the basis for determining greater distances. The most common approach has been to use a well-studied type of pulsating star known as a Cepheid variable, in conjunction with more distant supernovae to trace distances across the Universe. Scientists using this method and observations from the Hubble Space Telescope were able to measure the Hubble constant to within 10%. However, only independent checks would give them the confidence they desired, considering that much of our understanding of the Universe hangs in the balance. Chandra X-ray Image of MACS J1149.5+223 Chandra X-ray Image of MACS J1149.5+223 By combining X-ray data from Chandra with radio observations of galaxy clusters, the team determined the distances to 38 galaxy clusters ranging from 1.4 billion to 9.3 billion

14. Media independent interface

NASA Technical Reports Server (NTRS)

1987-01-01

The work done on the Media Independent Interface (MII) Interface Control Document (ICD) program is described and recommendations based on it were made. Explanations and rationale for the content of the ICD itself are presented.

15. Response variability of marmoset parvocellular neurons

PubMed Central

Victor, J D; Blessing, E M; Forte, J D; Buzás, P; Martin, P R

2007-01-01

This study concerns the properties of neurons carrying signals for colour vision in primates. We investigated the variability of responses of individual parvocellular lateral geniculate neurons of dichromatic and trichromatic marmosets to drifting sinusoidal luminance and chromatic gratings. Response variability was quantified by the cycle-to-cycle variation in Fourier components of the response. Averaged across the population, the variability at low contrasts was greater than predicted by a Poisson process, and at high contrasts the responses were approximately 40% more variable than responses at low contrasts. The contrast-dependent increase in variability was nevertheless below that expected from the increase in firing rate. Variability falls below the Poisson prediction at high contrast, and intrinsic variability of the spike train decreases as contrast increases. Thus, while deeply modulated responses in parvocellular cells have a larger absolute variability than weakly modulated ones, they have a more favourable signal: noise ratio than predicted by a Poisson process. Similar results were obtained from a small sample of magnocellular and koniocellular (‘blue-on’) neurons. For parvocellular neurons with pronounced colour opponency, chromatic responses were, on average, less variable (10–15%, p < 0.01) than luminance responses of equal magnitude. Conversely, non-opponent parvocellular neurons showed the opposite tendency. This is consistent with a supra-additive noise source prior to combination of cone signals. In summary, though variability of parvocellular neurons is largely independent of the way in which they combine cone signals, the noise characteristics of retinal circuitry may augment specialization of parvocellular neurons to signal luminance or chromatic contrast. PMID:17124265

16. New addition curing polyimides

NASA Technical Reports Server (NTRS)

Frimer, Aryeh A.; Cavano, Paul

1991-01-01

In an attempt to improve the thermal-oxidative stability (TOS) of PMR-type polymers, the use of 1,4-phenylenebis (phenylmaleic anhydride) PPMA, was evaluated. Two series of nadic end-capped addition curing polyimides were prepared by imidizing PPMA with either 4,4'-methylene dianiline or p-phenylenediamine. The first resulted in improved solubility and increased resin flow while the latter yielded a compression molded neat resin sample with a T(sub g) of 408 C, close to 70 C higher than PME-15. The performance of these materials in long term weight loss studies was below that of PMR-15, independent of post-cure conditions. These results can be rationalized in terms of the thermal lability of the pendant phenyl groups and the incomplete imidization of the sterically congested PPMA. The preparation of model compounds as well as future research directions are discussed.

17. Long-term variability of aerosol optical thickness in Eastern Europe over 2001-2014 according to the measurements at the Moscow MSU MO AERONET site with additional cloud and NO2 correction

NASA Astrophysics Data System (ADS)

Chubarova, N. Y.; Poliukhov, A. A.; Gorlova, I. D.

2015-07-01

The aerosol properties of the atmosphere were obtained within the framework of the AERONET program at the Moscow State University Meteorological Observatory (Moscow MSU MO) over 2001-2014 period. The quality data control has revealed the necessity of their additional cloud and NO2 correction. The application of cloud correction according to hourly visual cloud observations provides a decrease in average aerosol optical thickness (AOT) at 500 nm of up to 0.03 compared with the standard dataset. We also show that the additional NO2 correction of the AERONET data is needed in large megalopolis, like Moscow, with 12 million residents and the NOx emission rates of about 100 kt yr-1. According to the developed method we estimated monthly mean NO2 content, which provides an additional decrease of 0.01 for AOT at 340 nm, and of about 0.015 - for AOT at 380 and 440 nm. The ratios of NO2 optical thickness to AOT at 380 and 440 nm are about 5-6 % in summer and reach 15-20 % in winter when both factors have similar effects on UV irradiance. Seasonal cycle of AOT at 500 nm is characterized by a noticeable summer and spring maxima, and minimum in winter conditions, changing from 0.08 in December and January up to 0.3 in August. The application of the additional cloud correction removes a local AOT maximum in February, and lowered the December artificial high AOT values. The pronounced negative AOT trends of about -1-5 % yr-1 have been obtained for most months, which could be attributed to the negative trends in emissions (E) of different aerosol precursors of about 116 Gg yr-2 in ESOx, 78 Gg yr-2 in ENMVOC, and 272 Gg yr-2 in ECO over European territory of Russia. No influence of natural factors on temporal AOT variations has been revealed.

18. Independent technical review, handbook

SciTech Connect

Not Available

1994-02-01

Purpose Provide an independent engineering review of the major projects being funded by the Department of Energy, Office of Environmental Restoration and Waste Management. The independent engineering review will address questions of whether the engineering practice is sufficiently developed to a point where a major project can be executed without significant technical problems. The independent review will focus on questions related to: (1) Adequacy of development of the technical base of understanding; (2) Status of development and availability of technology among the various alternatives; (3) Status and availability of the industrial infrastructure to support project design, equipment fabrication, facility construction, and process and program/project operation; (4) Adequacy of the design effort to provide a sound foundation to support execution of project; (5) Ability of the organization to fully integrate the system, and direct, manage, and control the execution of a complex major project.

19. Multisensory integration is independent of perceived simultaneity.

PubMed

Harrar, Vanessa; Harris, Laurence R; Spence, Charles

2017-03-01

The importance of multisensory integration for perception and action has long been recognised. Integrating information from individual senses increases the chance of survival by reducing the variability in the incoming signals, thus allowing us to respond more rapidly. Reaction times (RTs) are fastest when the components of the multisensory signals are simultaneous. This response facilitation is traditionally attributed to multisensory integration. However, it is unclear if facilitation of RTs occurs when stimuli are perceived as synchronous or are actually physically synchronous. Repeated exposure to audiovisual asynchrony can change the delay at which multisensory stimuli are perceived as simultaneous, thus changing the delay at which the stimuli are integrated-perceptually. Here we set out to determine how such changes in multisensory integration for perception affect our ability to respond to multisensory events. If stimuli perceived as simultaneous were reacted to most rapidly, it would suggest a common system for multisensory integration for perception and action. If not, it would suggest separate systems. We measured RTs to auditory, visual, and audiovisual stimuli following exposure to audiovisual asynchrony. Exposure affected the variability of the unisensory RT distributions; in particular, the slowest RTs were either speed up or slowed down (in the direction predicted from shifts in perceived simultaneity). Additionally, the multisensory facilitation of RTs (beyond statistical summation) only occurred when audiovisual onsets were physically synchronous, rather than when they appeared simultaneous. We conclude that the perception of synchrony is therefore independent of multisensory integration and suggest a division between multisensory processes that are fast (automatic and unaffected by temporal adaptation) and those that are slow (perceptually driven and adaptable).

20. Long-term variability of aerosol optical thickness in Eastern Europe over 2001-2014 according to the measurements at the Moscow MSU MO AERONET site with additional cloud and NO2 correction

NASA Astrophysics Data System (ADS)

Chubarova, N. Y.; Poliukhov, A. A.; Gorlova, I. D.

2016-02-01

1. Homebirth and independent midwifery.

PubMed

Harris, G

2000-07-01

Why do women choose to give birth at home, and midwives to work independently, in a culture that does little to support this option? This article looks at the reasons childbearing women and midwives make these choices and the barriers to achieving them. The safety of the homebirth option is supported in reference to analysis of mortality and morbidity. Homebirth practices and level of success are compared in Australia and New Zealand (NZ), in particular, and The Netherlands, England and America. The success of popularity of homebirths is analysed in terms of socio-economic status. The current situation and challenges of independent midwifery in Darwin are described.

2. Postcard from Independence, Mo.

ERIC Educational Resources Information Center

Archer, Jeff

2004-01-01

This article reports results showing that the Independence, Missori school district failed to meet almost every one of its improvement goals under the No Child Left Behind Act. The state accreditation system stresses improvement over past scores, while the federal law demands specified amounts of annual progress toward the ultimate goal of 100…

3. Native American Independent Living.

ERIC Educational Resources Information Center

Clay, Julie Anna

1992-01-01

Examines features of independent living philosophy with regard to compatibility with Native American cultures, including definition or conceptualization of disability; self-advocacy; systems advocacy; peer counseling; and consumer control and involvement. Discusses an actualizing process as one method of resolving cultural conflicts and…

4. Touchstones of Independence.

ERIC Educational Resources Information Center

Roha, Thomas Arden

1999-01-01

Foundations affiliated with public higher education institutions can avoid having to open records for public scrutiny, by having independent boards of directors, occupying leased office space or paying market value for university space, using only foundation personnel, retaining legal counsel, being forthcoming with information and use of public…

5. Independent Video in Britain.

ERIC Educational Resources Information Center

Stewart, David

Maintaining the status quo as well as the attitude toward cultural funding and development that it imposes on video are detrimental to the formation of a thriving video network, and also out of key with the present social and political situation in Britain. Independent video has some quite specific advantages as a medium for cultural production…

6. Caring about Independent Lives

ERIC Educational Resources Information Center

Christensen, Karen

2010-01-01

With the rhetoric of independence, new cash for care systems were introduced in many developed welfare states at the end of the 20th century. These systems allow local authorities to pay people who are eligible for community care services directly, to enable them to employ their own careworkers. Despite the obvious importance of the careworker's…

7. Independence and Survival.

ERIC Educational Resources Information Center

James, H. Thomas

Independent schools that are of viable size, well managed, and strategically located to meet competition will survive and prosper past the current financial crisis. We live in a complex technological society with insatiable demands for knowledgeable people to keep it running. The future will be marked by the orderly selection of qualified people,…

8. Improvement in Mortality Risk Prediction Following Percutaneous Coronary Intervention Through Addition of a “Compassionate Use” Variable to the National Cardiovascular Data Registry CathPCI® Dataset: A Study from the Massachusetts Angioplasty Registry

PubMed Central

Resnic, Frederic S.; Normand, Sharon-Lise T.; Piemonte, Thomas C.; Shubrooks, Samuel J.; Zelevinsky, Katya; Lovett, Ann; Ho, Kalon K.L.

2011-01-01

9. Discriminating additive from dynamical noise for chaotic time series.

PubMed

Strumik, Marek; Macek, Wiesław M; Redaelli, Stefano

2005-09-01

We consider the dynamics of the Hénon and Ikeda maps in the presence of additive and dynamical noise. We show that, from the point of view of computations of some statistical quantities, dynamical noise corrupting these deterministic systems can be considered effectively as an additive "pseudonoise" with the Cauchy distribution. In the case of the Hénon and Ikeda maps, this effect occurs only for one variable of the system, while the noise corrupting the second variable is still Gaussian distributed independent of distribution of dynamical noise. Based on these results and using scaling properties of the correlation entropy, we propose a simple method of discriminating additive from dynamical noise. This approach is also useful for estimation of noise level for chaotic time series. We show that the proposed method works well in a wide range of noise levels, providing that one kind of noise predominates and we analyze the variable of the system for which the contamination follows Cauchy-like distribution in the presence of dynamical noise.

10. Synchrotron-Based X-ray Microtomography Characterization of the Effect of Processing Variables on Porosity Formation in Laser Power-Bed Additive Manufacturing of Ti-6Al-4V

NASA Astrophysics Data System (ADS)

Cunningham, Ross; Narra, Sneha P.; Montgomery, Colt; Beuth, Jack; Rollett, A. D.

2017-01-01

The porosity observed in additively manufactured (AM) parts is a potential concern for components intended to undergo high-cycle fatigue without post-processing to remove such defects. The morphology of pores can help identify their cause: irregularly shaped lack of fusion or key-holing pores can usually be linked to incorrect processing parameters, while spherical pores suggest trapped gas. Synchrotron-based x-ray microtomography was performed on laser powder-bed AM Ti-6Al-4V samples over a range of processing conditions to investigate the effects of processing parameters on porosity. The process mapping technique was used to control melt pool size. Tomography was also performed on the powder to measure porosity within the powder that may transfer to the parts. As observed previously in experiments with electron beam powder-bed fabrication, significant variations in porosity were found as a function of the processing parameters. A clear connection between processing parameters and resulting porosity formation mechanism was observed in that inadequate melt pool overlap resulted in lack-of-fusion pores whereas excess power density produced keyhole pores.

11. Synchrotron-Based X-ray Microtomography Characterization of the Effect of Processing Variables on Porosity Formation in Laser Power-Bed Additive Manufacturing of Ti-6Al-4V

NASA Astrophysics Data System (ADS)

Cunningham, Ross; Narra, Sneha P.; Montgomery, Colt; Beuth, Jack; Rollett, A. D.

2017-03-01

The porosity observed in additively manufactured (AM) parts is a potential concern for components intended to undergo high-cycle fatigue without post-processing to remove such defects. The morphology of pores can help identify their cause: irregularly shaped lack of fusion or key-holing pores can usually be linked to incorrect processing parameters, while spherical pores suggest trapped gas. Synchrotron-based x-ray microtomography was performed on laser powder-bed AM Ti-6Al-4V samples over a range of processing conditions to investigate the effects of processing parameters on porosity. The process mapping technique was used to control melt pool size. Tomography was also performed on the powder to measure porosity within the powder that may transfer to the parts. As observed previously in experiments with electron beam powder-bed fabrication, significant variations in porosity were found as a function of the processing parameters. A clear connection between processing parameters and resulting porosity formation mechanism was observed in that inadequate melt pool overlap resulted in lack-of-fusion pores whereas excess power density produced keyhole pores.

12. Agent independent task planning

NASA Technical Reports Server (NTRS)

Davis, William S.

1990-01-01

Agent-Independent Planning is a technique that allows the construction of activity plans without regard to the agent that will perform them. Once generated, a plan is then validated and translated into instructions for a particular agent, whether a robot, crewmember, or software-based control system. Because Space Station Freedom (SSF) is planned for orbital operations for approximately thirty years, it will almost certainly experience numerous enhancements and upgrades, including upgrades in robotic manipulators. Agent-Independent Planning provides the capability to construct plans for SSF operations, independent of specific robotic systems, by combining techniques of object oriented modeling, nonlinear planning and temporal logic. Since a plan is validated using the physical and functional models of a particular agent, new robotic systems can be developed and integrated with existing operations in a robust manner. This technique also provides the capability to generate plans for crewmembers with varying skill levels, and later apply these same plans to more sophisticated robotic manipulators made available by evolutions in technology.

13. International exploration by independent

SciTech Connect

Bertragne, R.G.

1992-04-01

Recent industry trends indicate that the smaller U.S. independents are looking at foreign exploration opportunities as one of the alternatives for growth in the new age of exploration. Foreign finding costs per barrel usually are accepted to be substantially lower than domestic costs because of the large reserve potential of international plays. To get involved in overseas exploration, however, requires the explorationist to adapt to different cultural, financial, legal, operational, and political conditions. Generally, foreign exploration proceeds at a slower pace than domestic exploration because concessions are granted by a country's government, or are explored in partnership with a national oil company. First, the explorationist must prepare a mid- to long-term strategy, tailored to the goals and the financial capabilities of the company; next, is an ongoing evaluation of quality prospects in various sedimentary basins, and careful planning and conduct of the operations. To successfully explore overseas also requires the presence of a minimum number of explorationists and engineers thoroughly familiar with the various exploratory and operational aspects of foreign work. Ideally, these team members will have had a considerable amount of on-site experience in various countries and climates. Independents best suited for foreign expansion are those who have been financially successful in domestic exploration. When properly approached, foreign exploration is well within the reach of smaller U.S. independents, and presents essentially no greater risk than domestic exploration; however, the reward can be much larger and can catapult the company into the 'big leagues.'

14. International exploration by independents

SciTech Connect

Bertagne, R.G. )

1991-03-01

Recent industry trends indicate that the smaller US independents are looking at foreign exploration opportunities as one of the alternatives for growth in the new age of exploration. It is usually accepted that foreign finding costs per barrel are substantially lower than domestic because of the large reserve potential of international plays. To get involved overseas requires, however, an adaptation to different cultural, financial, legal, operational, and political conditions. Generally foreign exploration proceeds at a slower pace than domestic because concessions are granted by the government, or are explored in partnership with the national oil company. First, a mid- to long-term strategy, tailored to the goals and the financial capabilities of the company, must be prepared; it must be followed by an ongoing evaluation of quality prospects in various sedimentary basins, and a careful planning and conduct of the operations. To successfully explore overseas also requires the presence on the team of a minimum number of explorationists and engineers thoroughly familiar with the various exploratory and operational aspects of foreign work, having had a considerable amount of onsite experience in various geographical and climatic environments. Independents that are best suited for foreign expansion are those that have been financially successful domestically, and have a good discovery track record. When properly approached foreign exploration is well within the reach of smaller US independents and presents essentially no greater risk than domestic exploration; the reward, however, can be much larger and can catapult the company into the big leagues.

15. Why Additional Presentations Help Identify a Stimulus

ERIC Educational Resources Information Center

Guest, Duncan; Kent, Christopher; Adelman, James S.

2010-01-01

Nosofsky (1983) reported that additional stimulus presentations within a trial increase discriminability in absolute identification, suggesting that each presentation creates an independent stimulus representation, but it remains unclear whether exposure duration or the formation of independent representations improves discrimination in such…

16. Uniform Additivity in Classical and Quantum Information

NASA Astrophysics Data System (ADS)

Cross, Andrew; Li, Ke; Smith, Graeme

2017-01-01

Information theory quantifies the optimal rates of resource interconversions, usually in terms of entropies. However, nonadditivity often makes evaluating entropic formulas intractable. In a few auspicious cases, additivity allows a full characterization of optimal rates. We study uniform additivity of formulas, which is easily evaluated and captures all known additive quantum formulas. Our complete characterization of uniform additivity exposes an intriguing new additive quantity and identifies a remarkable coincidence—the classical and quantum uniformly additive functions with one auxiliary variable are identical.

17. Multi-Wheat-Model Ensemble Responses to Interannual Climate Variability

NASA Technical Reports Server (NTRS)

Ruane, Alex C.; Hudson, Nicholas I.; Asseng, Senthold; Camarrano, Davide; Ewert, Frank; Martre, Pierre; Boote, Kenneth J.; Thorburn, Peter J.; Aggarwal, Pramod K.; Angulo, Carlos

2016-01-01

We compare 27 wheat models' yield responses to interannual climate variability, analyzed at locations in Argentina, Australia, India, and The Netherlands as part of the Agricultural Model Intercomparison and Improvement Project (AgMIP) Wheat Pilot. Each model simulated 1981e2010 grain yield, and we evaluate results against the interannual variability of growing season temperature, precipitation, and solar radiation. The amount of information used for calibration has only a minor effect on most models' climate response, and even small multi-model ensembles prove beneficial. Wheat model clusters reveal common characteristics of yield response to climate; however models rarely share the same cluster at all four sites indicating substantial independence. Only a weak relationship (R2 0.24) was found between the models' sensitivities to interannual temperature variability and their response to long-termwarming, suggesting that additional processes differentiate climate change impacts from observed climate variability analogs and motivating continuing analysis and model development efforts.

18. Variables associated with upper extremity function in patients with Duchenne muscular dystrophy.

PubMed

Janssen, Mariska M H P; Hendriks, Jan C M; Geurts, Alexander C H; de Groot, Imelda J M

2016-09-01

Preserving upper extremity (UE) function in patients with Duchenne muscular dystrophy (DMD) is extremely important as it is related to independence and quality of life. For clinical decision making, knowledge of variables associated with UE function is necessary. This knowledge is, however, limited. Therefore, this study aims to gain more insight into the variables associated with UE function in DMD. Data from an international web-based questionnaire on UE function, obtained from 213 DMD patients, were used. Six dependent variables regarding UE function were used in multivariable linear regression analyses. In addition, 26 independent variables regarding patient characteristics, medication, therapy, supportive aids, pain, stiffness and participation were used. Twelve independent variables showed a significant relation to UE function. Variables with a negative relation to UE function were: later disease stage, occurrence of scoliosis, higher age, use of UE splints, more frequent stiffness complaints, more limitations due to stiffness, more frequent elbow pain, and having physical therapy. A positive relation with UE function was seen for going to school or work, use of corticosteroids, higher BMI, and higher age at diagnosis. These variables explained 56-81 % of the variation of the different measures of UE function. Knowledge of variables associated with UE function is very important in the clinical management of DMD patients. The results of this study suggest that corticosteroid use and participation in school and work related activities are positively related to UE function in DMD patients, as well as reducing pain and stiffness and preventing scoliosis.

19. Ashtekar variables

NASA Astrophysics Data System (ADS)

Ashtekar, Abhay

2015-05-01

In the spirit of Scholarpedia, this invited article is addressed to students and younger researchers. It provides the motivation and background material, a summary of the main physical ideas, mathematical structures and results, and an outline of applications of the connection variables for general relativity. These variables underlie both the canonical/Hamiltonian and the spinfoam/path integral approaches in loop quantum gravity.

20. Cary Potter on Independent Education

ERIC Educational Resources Information Center

Potter, Cary

1978-01-01

Cary Potter was President of the National Association of Independent Schools from 1964-1978. As he leaves NAIS he gives his views on education, on independence, on the independent school, on public responsibility, on choice in a free society, on educational change, and on the need for collective action by independent schools. (Author/RK)

1. Myth or Truth: Independence Day.

ERIC Educational Resources Information Center

Gardner, Traci

Most Americans think of the Fourth of July as Independence Day, but is it really the day the U.S. declared and celebrated independence? By exploring myths and truths surrounding Independence Day, this lesson asks students to think critically about commonly believed stories regarding the beginning of the Revolutionary War and the Independence Day…

2. Relative Reinforcer Rates and Magnitudes Do Not Control Concurrent Choice Independently

ERIC Educational Resources Information Center

Elliffe, Douglas; Davison, Michael; Landon, Jason

2008-01-01

One assumption of the matching approach to choice is that different independent variables control choice independently of each other. We tested this assumption for reinforcer rate and magnitude in an extensive parametric experiment. Five pigeons responded for food reinforcement on switching-key concurrent variable-interval variable-interval…

3. Independence and dependence in human causal reasoning.

PubMed

Rehder, Bob

2014-07-01

Causal graphical models (CGMs) are a popular formalism used to model human causal reasoning and learning. The key property of CGMs is the causal Markov condition, which stipulates patterns of independence and dependence among causally related variables. Five experiments found that while adult's causal inferences exhibited aspects of veridical causal reasoning, they also exhibited a small but tenacious tendency to violate the Markov condition. They also failed to exhibit robust discounting in which the presence of one cause as an explanation of an effect makes the presence of another less likely. Instead, subjects often reasoned "associatively," that is, assumed that the presence of one variable implied the presence of other, causally related variables, even those that were (according to the Markov condition) conditionally independent. This tendency was unaffected by manipulations (e.g., response deadlines) known to influence fast and intuitive reasoning processes, suggesting that an associative response to a causal reasoning question is sometimes the product of careful and deliberate thinking. That about 60% of the erroneous associative inferences were made by about a quarter of the subjects suggests the presence of substantial individual differences in this tendency. There was also evidence that inferences were influenced by subjects' assumptions about factors that disable causal relations and their use of a conjunctive reasoning strategy. Theories that strive to provide high fidelity accounts of human causal reasoning will need to relax the independence constraints imposed by CGMs.

4. Compact programmable photonic variable delay devices

NASA Technical Reports Server (NTRS)

Yao, X. Steve (Inventor)

1999-01-01

Optical variable delay devices for providing variable true time delay to multiple optical beams simultaneously. A ladder-structured variable delay device comprises multiple basic building blocks stacked on top of each other resembling a ladder. Each basic building block has two polarization beamsplitters and a polarization rotator array arranged to form a trihedron; Controlling an array element of the polarization rotator array causes a beam passing through the array element either going up to a basic building block above it or reflect back towards a block below it. The beams going higher on the ladder experience longer optical path delay. An index-switched optical variable delay device comprises of many birefringent crystal segments connected with one another, with a polarization rotator array sandwiched between any two adjacent crystal segments. An array element in the polarization rotator array controls the polarization state of a beam passing through the element, causing the beam experience different refractive indices or path delays in the following crystal segment. By independently control each element in each polarization rotator array, variable optical path delays of each beam can be achieved. Finally, an index-switched variable delay device and a ladder-structured variable device are cascaded to form a new device which combines the advantages of the two individual devices. This programmable optic device has the properties of high packing density, low loss, easy fabrication, and virtually infinite bandwidth. The device is inherently two dimensional and has a packing density exceeding 25 lines/cm.sup.2. The delay resolution of the device is on the order of a femtosecond (one micron in space) and the total delay exceeds 10 nanosecond. In addition, the delay is reversible so that the same delay device can be used for both antenna transmitting and receiving.

5. Sleep problems and heart rate variability over the working day.

PubMed

Jackowska, Marta; Dockray, Samantha; Endrighi, Romano; Hendrickx, Hilde; Steptoe, Andrew

2012-08-01

The purpose of this study was to discover whether greater sleep problems are associated with reduced heart rate variability during working hours and at night, and to determine whether this association is in part mediated by experienced affective states. This study involved 199 working women with a mean age of 33.8years. Sleep problems were assessed with the Jenkins Sleep Problems Scale, and the Day Reconstruction Method was used to measure positive affect and stress on the evening before and during the working day. Heart rate variability was indexed by the mean square root of the successive standard difference in heart period. Disturbed sleep was inversely related to heart rate variability during the working day (P=0.022), independently of demographic and behavioural confounders. Additional adjustment for positive affect and stress did not lead to further reductions in the association between sleep problems and reduced heart rate variability over the work day. Sleep problems were not predictive of reduced night-time heart rate variability. This report extends the findings from experimental studies and clinical samples, and suggests that disturbed sleep might impair heart rate variability in real life settings, in particular during working hours. Reduced heart rate variability might be a potential pathway linking sleep problems with cardiovascular disease. Based on the current data there was little evidence that the inverse associations between sleep problems and heart rate variability were mediated by experienced affective states.

6. Variable Order and Distributed Order Fractional Operators

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.; Hartley, Tom T.

2002-01-01

Many physical processes appear to exhibit fractional order behavior that may vary with time or space. The continuum of order in the fractional calculus allows the order of the fractional operator to be considered as a variable. This paper develops the concept of variable and distributed order fractional operators. Definitions based on the Riemann-Liouville definitions are introduced and behavior of the operators is studied. Several time domain definitions that assign different arguments to the order q in the Riemann-Liouville definition are introduced. For each of these definitions various characteristics are determined. These include: time invariance of the operator, operator initialization, physical realization, linearity, operational transforms. and memory characteristics of the defining kernels. A measure (m2) for memory retentiveness of the order history is introduced. A generalized linear argument for the order q allows the concept of "tailored" variable order fractional operators whose a, memory may be chosen for a particular application. Memory retentiveness (m2) and order dynamic behavior are investigated and applications are shown. The concept of distributed order operators where the order of the time based operator depends on an additional independent (spatial) variable is also forwarded. Several definitions and their Laplace transforms are developed, analysis methods with these operators are demonstrated, and examples shown. Finally operators of multivariable and distributed order are defined in their various applications are outlined.

7. A Survey of Phase Variable Candidates of Human Locomotion

PubMed Central

Villarreal, Dario J.; Gregg, Robert D.

2014-01-01

Studies show that the human nervous system is able to parameterize gait cycle phase using sensory feedback. In the field of bipedal robots, the concept of a phase variable has been successfully used to mimic this behavior by parameterizing the gait cycle in a time-independent manner. This approach has been applied to control a powered transfemoral prosthetic leg, but the proposed phase variable was limited to the stance period of the prosthesis only. In order to achieve a more robust controller, we attempt to find a new phase variable that fully parameterizes the gait cycle of a prosthetic leg. The angle with respect to a global reference frame at the hip is able to monotonically parameterize both the stance and swing periods of the gait cycle. This survey looks at multiple phase variable candidates involving the hip angle with respect to a global reference frame across multiple tasks including level-ground walking, running, and stair negotiation. In particular, we propose a novel phase variable candidate that monotonically parameterizes the whole gait cycle across all tasks, and does so particularly well across level-ground walking. In addition to furthering the design of robust robotic prosthetic leg controllers, this survey could help neuroscientists and physicians study human locomotion across tasks from a time-independent perspective. PMID:25570873

8. Prioritizing Highway Safety Manual's crash prediction variables using boosted regression trees.

PubMed

Saha, Dibakar; Alluri, Priyanka; Gan, Albert

2015-06-01

The Highway Safety Manual (HSM) recommends using the empirical Bayes (EB) method with locally derived calibration factors to predict an agency's safety performance. However, the data needs for deriving these local calibration factors are significant, requiring very detailed roadway characteristics information. Many of the data variables identified in the HSM are currently unavailable in the states' databases. Moreover, the process of collecting and maintaining all the HSM data variables is cost-prohibitive. Prioritization of the variables based on their impact on crash predictions would, therefore, help to identify influential variables for which data could be collected and maintained for continued updates. This study aims to determine the impact of each independent variable identified in the HSM on crash predictions. A relatively recent data mining approach called boosted regression trees (BRT) is used to investigate the association between the variables and crash predictions. The BRT method can effectively handle different types of predictor variables, identify very complex and non-linear association among variables, and compute variable importance. Five years of crash data from 2008 to 2012 on two urban and suburban facility types, two-lane undivided arterials and four-lane divided arterials, were analyzed for estimating the influence of variables on crash predictions. Variables were found to exhibit non-linear and sometimes complex relationship to predicted crash counts. In addition, only a few variables were found to explain most of the variation in the crash data.

9. Turkish Pre-Service Science and Mathematics Teachers' Computer Related Self-Efficacies, Attitudes, and the Relationship between These Variables

ERIC Educational Resources Information Center

Pamuk, Savas; Peker, Deniz

2009-01-01

The purpose of this study was to investigate Turkish pre-service science and mathematics teachers' computer self-efficacies (CSEs) and computer attitude (CA) considering gender, year in program, and computer ownership as independent variables. Additionally the study aimed to examine the relationship between CSE and CA. Computer Self-efficacy Scale…

10. TabVar: Tabulated Variables

SciTech Connect

Bachan, John

2015-12-15

TabVar: A Python library for manipulating datasets in the form of tabulated variables. Tables in tabvar contain many columns representing independent variables, but exactly one distinguished column for the dependent variable. Having a single distinguished column allows a natural lifting of arithmetic operators to tables, much (and in fact fully generalizing) multidimensional array arithmetic. The convenient syntax of whole-table arithmetic, along with the usual operations of filtering and aggregation, and all in the setting of python's interactive REPL allows for rapid exploration of datasets.

11. Variable Lifting Index (VLI)

PubMed Central

Waters, Thomas; Occhipinti, Enrico; Colombini, Daniela; Alvarez-Casado, Enrique; Fox, Robert

2015-01-01

Objective: We seek to develop a new approach for analyzing the physical demands of highly variable lifting tasks through an adaptation of the Revised NIOSH (National Institute for Occupational Safety and Health) Lifting Equation (RNLE) into a Variable Lifting Index (VLI). Background: There are many jobs that contain individual lifts that vary from lift to lift due to the task requirements. The NIOSH Lifting Equation is not suitable in its present form to analyze variable lifting tasks. Method: In extending the prior work on the VLI, two procedures are presented to allow users to analyze variable lifting tasks. One approach involves the sampling of lifting tasks performed by a worker over a shift and the calculation of the Frequency Independent Lift Index (FILI) for each sampled lift and the aggregation of the FILI values into six categories. The Composite Lift Index (CLI) equation is used with lifting index (LI) category frequency data to calculate the VLI. The second approach employs a detailed systematic collection of lifting task data from production and/or organizational sources. The data are organized into simplified task parameter categories and further aggregated into six FILI categories, which also use the CLI equation to calculate the VLI. Results: The two procedures will allow practitioners to systematically employ the VLI method to a variety of work situations where highly variable lifting tasks are performed. Conclusions: The scientific basis for the VLI procedure is similar to that for the CLI originally presented by NIOSH; however, the VLI method remains to be validated. Application: The VLI method allows an analyst to assess highly variable manual lifting jobs in which the task characteristics vary from lift to lift during a shift. PMID:26646300

12. Glucose Variability

PubMed Central

Le Floch, Jean-Pierre; Kessler, Laurence

2016-01-01

Background: Glucose variability has been suspected to be a major factor of diabetic complications. Several indices have been proposed for measuring glucose variability, but their interest remains discussed. Our aim was to compare different indices. Methods: Glucose variability was studied in 150 insulin-treated diabetic patients (46% men, 42% type 1 diabetes, age 52 ± 11 years) using a continuous glucose monitoring system (668 ± 564 glucose values; mean glucose value 173 ± 38 mg/dL). Results from the mean, the median, different indices (SD, MAGE, MAG, glucose fluctuation index (GFI), and percentages of low [<60 mg/dL] and high [>180 mg/dL] glucose values), and ratios (CV = SD/m, MAGE/m, MAG/m, and GCF = GFI/m) were compared using Pearson linear correlations and a multivariate principal component analysis (PCA). Results: CV, MAGE/m (ns), GCF and GFI (P < .05), MAG and MAG/m (P < .01) were not strongly correlated with the mean. The percentage of high glucose values was mainly correlated with indices. The percentage of low glucose values was mainly correlated with ratios. PCA showed 3 main axes; the first was associated with descriptive data (mean, SD, CV, MAGE, MAGE/m, and percentage of high glucose values); the second with ratios MAG/m and GCF and with the percentage of low glucose values; and the third with MAG, GFI, and the percentage of high glucose values. Conclusions: Indices and ratios provide complementary pieces of information associated with high and low glucose values, respectively. The pairs MAG+MAG/m and GFI+GCF appear to be the most reliable markers of glucose variability in diabetic patients. PMID:26880391

13. QT variability.

PubMed

Berger, Ronald D

2003-01-01

We hypothesized that temporal lability in ventricular repolarization is a marker for, and is mechanistically related to, increased risk of malignant ventricular arrhythmias. To assess repolarization lability in the surface electrocardiogram, we developed an automated algorithm, based on template matching, to measure beat-to-beat changes in QT interval. We calculate a QT variability index (QTVI) to quantify the relative magnitude of QT interval changes compared to heart rate variability. We found that QTVI is a reproducible measure. It is elevated in patients with ischemic and nonischemic dilated cardiomyopathy compared with age-matched controls (P<.00001). We have also shown that QTVI is elevated in patients with malignant beta-myosin heavy-chain mutations associated with hypertrophic cardiomyopathy. In a study of patients undergoing electrophysiologic testing, QTVI identified patients with cardiac arrest better than electrophysiologic test result and better than other risk stratifiers included in the analysis. QT variability is a marker of electrical disease in the ventricle and may be associated with enhanced risk of life-threatening arrhythmias.

14. Additive Similarity Trees

ERIC Educational Resources Information Center

Sattath, Shmuel; Tversky, Amos

1977-01-01

Tree representations of similarity data are investigated. Hierarchical clustering is critically examined, and a more general procedure, called the additive tree, is presented. The additive tree representation is then compared to multidimensional scaling. (Author/JKS)

15. Polyimide processing additives

NASA Technical Reports Server (NTRS)

Pratt, J. R.; St. Clair, T. L.; Burks, H. D.; Stoakley, D. M.

1987-01-01

A method has been found for enhancing the melt flow of thermoplastic polyimides during processing. A high molecular weight 422 copoly(amic acid) or copolyimide was fused with approximately 0.05 to 5 pct by weight of a low molecular weight amic acid or imide additive, and this melt was studied by capillary rheometry. Excellent flow and improved composite properties on graphite resulted from the addition of a PMDA-aniline additive to LARC-TPI. Solution viscosity studies imply that amic acid additives temporarily lower molecular weight and, hence, enlarge the processing window. Thus, compositions containing the additive have a lower melt viscosity for a longer time than those unmodified.

16. [Food additives and healthiness].

PubMed

Heinonen, Marina

2014-01-01

Additives are used for improving food structure or preventing its spoilage, for example. Many substances used as additives are also naturally present in food. The safety of additives is evaluated according to commonly agreed principles. If high concentrations of an additive cause adverse health effects for humans, a limit of acceptable daily intake (ADI) is set for it. An additive is a risk only when ADI is exceeded. The healthiness of food is measured on the basis of nutrient density and scientifically proven effects.

17. [Factors associated with the addition of salt to prepared food].

PubMed

de Castro, Raquel da Silva Assunção; Giatti, Luana; Barreto, Sandhi Maria

2014-05-01

The scope of this research was to investigate the potential differences between men and women in the addition of salt to prepared food. The study included 47,557 individuals aged 18 to 64 participating in the Risk and Protection Factors for Chronic Disease Surveillance System by Telephone Interview carried out in 26 Brazilian state capitals and the Federal District in 2006. Differences between men and women were tested by the chi-square test and the association magnitudes between the dependent and independent variables were estimated by the Odds Ratio obtained by Multiple Logistic Regression analysis. The prevalence of the addition of salt to prepared food was 8.3%, being higher among men (9,8% vs 6,9%, p < 0.01). After adjustment, the addition of salt to prepared food was higher in individuals with self-rated fair to poor health, reporting cardiovascular disease and living in the North of Brazil. Hypertensive individuals reported addition of less salt to prepared food. Educational level was not associated with salt usage. Men add more salt than women. Public health policies aimed at reducing salt intake by the population should take into account the gender differences in salt intake and the factors that contribute to such differences.

18. Reading Achievement and Social Selection in Independent Schools in Sweden: Results from IEA PIRLS 2001

ERIC Educational Resources Information Center

Myrberg, Eva; Rosen, Monica

2006-01-01

The study investigates the mean difference in reading achievement between third-graders in public and independent schools in Sweden. The data come from the Swedish participation in PIRLS 2001 conducted by IEA. Variables from the home questionnaire mainly indicating possession of cultural capital are used as independent variables. A total IRT score…

19. Device-independent quantum key distribution

NASA Astrophysics Data System (ADS)

Hänggi, Esther

2010-12-01

In this thesis, we study two approaches to achieve device-independent quantum key distribution: in the first approach, the adversary can distribute any system to the honest parties that cannot be used to communicate between the three of them, i.e., it must be non-signalling. In the second approach, we limit the adversary to strategies which can be implemented using quantum physics. For both approaches, we show how device-independent quantum key distribution can be achieved when imposing an additional condition. In the non-signalling case this additional requirement is that communication is impossible between all pairwise subsystems of the honest parties, while, in the quantum case, we demand that measurements on different subsystems must commute. We give a generic security proof for device-independent quantum key distribution in these cases and apply it to an existing quantum key distribution protocol, thus proving its security even in this setting. We also show that, without any additional such restriction there always exists a successful joint attack by a non-signalling adversary.

20. Independent Learning Models: A Comparison.

ERIC Educational Resources Information Center

Wickett, R. E. Y.

Five models of independent learning are suitable for use in adult education programs. The common factor is a facilitator who works in some way with the student in the learning process. They display different characteristics, including the extent of independence in relation to content and/or process. Nondirective tutorial instruction and learning…

1. Regression Analysis with Dummy Variables: Use and Interpretation.

ERIC Educational Resources Information Center

Hinkle, Dennis E.; Oliver, J. Dale

1986-01-01

Multiple regression analysis (MRA) may be used when both continuous and categorical variables are included as independent research variables. The use of MRA with categorical variables involves dummy coding, that is, assigning zeros and ones to levels of categorical variables. Caution is urged in results interpretation. (Author/CH)

2. Polylactides in additive biomanufacturing.

PubMed

Poh, Patrina S P; Chhaya, Mohit P; Wunner, Felix M; De-Juan-Pardo, Elena M; Schilling, Arndt F; Schantz, Jan-Thorsten; van Griensven, Martijn; Hutmacher, Dietmar W

2016-12-15

3. Additive Manufactured Product Integrity

NASA Technical Reports Server (NTRS)

Waller, Jess; Wells, Doug; James, Steve; Nichols, Charles

2017-01-01

NASA is providing key leadership in an international effort linking NASA and non-NASA resources to speed adoption of additive manufacturing (AM) to meet NASA's mission goals. Participants include industry, NASA's space partners, other government agencies, standards organizations and academia. Nondestructive Evaluation (NDE) is identified as a universal need for all aspects of additive manufacturing.

4. Assessing Early Intervention Outcomes: Beyond Program Variables.

ERIC Educational Resources Information Center

Marfo, Kofi; Dinero, Thomas E.

1991-01-01

This paper argues that efficacy of early intervention must be assessed in relation to both program and extra-program variables. A framework outlining five classes of independent variables and two classes of outcomes to be considered in efficacy research is presented, and regression and path analytic techniques are suggested as tools for addressing…

5. Examining Variability in Superintendent Community Involvement

ERIC Educational Resources Information Center

Kowalski, Theodore J.; Young, I. Phillip; Petersen, George J.

2013-01-01

This study examined the extent to which four independent variables (age, gender, education level, and district type) accounted for variability in superintendent community involvement. Two covariates associated with levels of community involvement (disposition toward community involvement and district enrollment) were infused to assess the impact…

6. Scale-Independent Measures and Pathologic Cardiac Dynamics

NASA Astrophysics Data System (ADS)

Amaral, Luís A.; Goldberger, Ary L.; Ivanov, Plamen Ch.; Stanley, H. Eugene

1998-09-01

We study several scale-independent measures of cardiac interbeat interval dynamics defined through the application of the wavelet transform. We test their performance in detecting heart disease using a database consisting of records of interbeat intervals for a group of healthy individuals and subjects with congestive heart failure. We find that scale-independent measures effectively distinguish healthy from pathologic behavior and propose a new two-variable scale-independent measure that could be clinically useful. We compare the performance of a recently proposed scale-dependent measure and find that the results depend on the database analyzed and on the analyzing wavelet.

7. Progress in cultivation-independent phyllosphere microbiology

PubMed Central

Müller, Thomas; Ruppel, Silke

2014-01-01

Most microorganisms of the phyllosphere are nonculturable in commonly used media and culture conditions, as are those in other natural environments. This review queries the reasons for their ‘noncultivability’ and assesses developments in phyllospere microbiology that have been achieved cultivation independently over the last 4 years. Analyses of total microbial communities have revealed a comprehensive microbial diversity. 16S rRNA gene amplicon sequencing and metagenomic sequencing were applied to investigate plant species, location and season as variables affecting the composition of these communities. In continuation to culture-based enzymatic and metabolic studies with individual isolates, metaproteogenomic approaches reveal a great potential to study the physiology of microbial communities in situ. Culture-independent microbiological technologies as well advances in plant genetics and biochemistry provide methodological preconditions for exploring the interactions between plants and their microbiome in the phyllosphere. Improving and combining cultivation and culture-independent techniques can contribute to a better understanding of the phyllosphere ecology. This is essential, for example, to avoid human–pathogenic bacteria in plant food. PMID:24003903

8. Progress in cultivation-independent phyllosphere microbiology.

PubMed

Müller, Thomas; Ruppel, Silke

2014-01-01

Most microorganisms of the phyllosphere are nonculturable in commonly used media and culture conditions, as are those in other natural environments. This review queries the reasons for their 'noncultivability' and assesses developments in phyllospere microbiology that have been achieved cultivation independently over the last 4 years. Analyses of total microbial communities have revealed a comprehensive microbial diversity. 16S rRNA gene amplicon sequencing and metagenomic sequencing were applied to investigate plant species, location and season as variables affecting the composition of these communities. In continuation to culture-based enzymatic and metabolic studies with individual isolates, metaproteogenomic approaches reveal a great potential to study the physiology of microbial communities in situ. Culture-independent microbiological technologies as well advances in plant genetics and biochemistry provide methodological preconditions for exploring the interactions between plants and their microbiome in the phyllosphere. Improving and combining cultivation and culture-independent techniques can contribute to a better understanding of the phyllosphere ecology. This is essential, for example, to avoid human-pathogenic bacteria in plant food.

9. THE COLOR VARIABILITY OF QUASARS

SciTech Connect

Schmidt, Kasper B.; Rix, Hans-Walter; Knecht, Matthias; Hogg, David W.; Shields, Joseph C.; Maoz, Dan; Bovy, Jo

2012-01-10

We quantify quasar color variability using an unprecedented variability database-ugriz photometry of 9093 quasars from Sloan Digital Sky Survey (SDSS) Stripe 82, observed over 8 years at {approx}60 epochs each. We confirm previous reports that quasars become bluer when brightening. We find a redshift dependence of this blueing in a given set of bands (e.g., g and r), but show that it is the result of the flux contribution from less-variable or delayed emission lines in the different SDSS bands at different redshifts. After correcting for this effect, quasar color variability is remarkably uniform, and independent not only of redshift, but also of quasar luminosity and black hole mass. The color variations of individual quasars, as they vary in brightness on year timescales, are much more pronounced than the ranges in color seen in samples of quasars across many orders of magnitude in luminosity. This indicates distinct physical mechanisms behind quasar variability and the observed range of quasar luminosities at a given black hole mass-quasar variations cannot be explained by changes in the mean accretion rate. We do find some dependence of the color variability on the characteristics of the flux variations themselves, with fast, low-amplitude, brightness variations producing more color variability. The observed behavior could arise if quasar variability results from flares or ephemeral hot spots in an accretion disk.

10. Sequence independent amplification of DNA

DOEpatents

Bohlander, Stefan K.

1998-01-01

The present invention is a rapid sequence-independent amplification procedure (SIA). Even minute amounts of DNA from various sources can be amplified independent of any sequence requirements of the DNA or any a priori knowledge of any sequence characteristics of the DNA to be amplified. This method allows, for example the sequence independent amplification of microdissected chromosomal material and the reliable construction of high quality fluorescent in situ hybridization (FISH) probes from YACs or from other sources. These probes can be used to localize YACs on metaphase chromosomes but also--with high efficiency--in interphase nuclei.

11. Sequence independent amplification of DNA

DOEpatents

Bohlander, S.K.

1998-03-24

The present invention is a rapid sequence-independent amplification procedure (SIA). Even minute amounts of DNA from various sources can be amplified independent of any sequence requirements of the DNA or any a priori knowledge of any sequence characteristics of the DNA to be amplified. This method allows, for example, the sequence independent amplification of microdissected chromosomal material and the reliable construction of high quality fluorescent in situ hybridization (FISH) probes from YACs or from other sources. These probes can be used to localize YACs on metaphase chromosomes but also--with high efficiency--in interphase nuclei. 25 figs.

12. Polyimide processing additives

NASA Technical Reports Server (NTRS)

Fletcher, James C. (Inventor); Pratt, J. Richard (Inventor); St.clair, Terry L. (Inventor); Stoakley, Diane M. (Inventor); Burks, Harold D. (Inventor)

1992-01-01

A process for preparing polyimides having enhanced melt flow properties is described. The process consists of heating a mixture of a high molecular weight poly-(amic acid) or polyimide with a low molecular weight amic acid or imide additive in the range of 0.05 to 15 percent by weight of additive. The polyimide powders so obtained show improved processability, as evidenced by lower melt viscosity by capillary rheometry. Likewise, films prepared from mixtures of polymers with additives show improved processability with earlier onset of stretching by TMA.

13. Polyimide processing additives

NASA Technical Reports Server (NTRS)

Pratt, J. Richard (Inventor); St.clair, Terry L. (Inventor); Stoakley, Diane M. (Inventor); Burks, Harold D. (Inventor)

1993-01-01

A process for preparing polyimides having enhanced melt flow properties is described. The process consists of heating a mixture of a high molecular weight poly-(amic acid) or polyimide with a low molecular weight amic acid or imide additive in the range of 0.05 to 15 percent by weight of the additive. The polyimide powders so obtained show improved processability, as evidenced by lower melt viscosity by capillary rheometry. Likewise, films prepared from mixtures of polymers with additives show improved processability with earlier onset of stretching by TMA.

14. New independent software packages based on the MODIS aerosol algorithms

NASA Astrophysics Data System (ADS)

Mattoo, S.

2009-05-01

The MODIS aerosol algorithms have nearly an 8 year history of producing validated aerosol products. During this period the algorithms have been adjusted and updated to both improve accuracy of the retrievals and to provide new capabilities. MODIS algorithm codes have always been open source, but users outside of the MODIS team have found them difficult to use because they are so tightly wedded to the operational processing. Recently we have added several new software packages that can be acquired from the MODIS aerosol team, and used independently of the MODIS operational computing environment. Specifically, we now have an easily transported 'stand alone code' that will process MODIS Level 1 radiance data and produce the MOD04/MYD04 Level 2 product without needing the operational MODIS 'tool kits'. Users can take this code and experiment with it, changing the operational algorithm to meet their own particular needs. In addition to this 'stand alone code', we now provide an independent software package that creates a cloud mask based on the spatial variability criteria pioneered by Martins et al., (2002) and the cirrus reflectance tests developed by Gao et al., (2002). This software produces a field of '1's and '0's on a 500 m resolution that indicate which pixels are cloudy and which are not, as defined by the aerosol team's cloud mask. The third piece of software is still in development, but will label each non-cloudy pixel as to its distance from the nearest cloud. This third piece of software will make it easier to estimate the amount of cloud contamination in the aerosol product and to pursue satellite-based studies of aerosol-cloud interaction. These codes, and additional new software that we develop will be available to the international research community, and can be acquired at any time from the MODIS aerosol team. Gao, B.-C., Y.J. Kaufman, D. Tanré and R.-R. Li, 2002: Distinguishing tropospheric aerosols from thin cirrus clouds for improved aerosol

15. The variability of RY LUPI

NASA Astrophysics Data System (ADS)

Evans, A.; Bode, M. F.; Whittet, D. C. B.; Davies, J. K.; Kilkenny, D.; Baines, D. W. T.

1982-05-01

Simultaneous optical and infrared broadband photometry (between 0.35 and 3.5 microns) and H-beta index photometry are obtained for the T Tauri star RY Lupi. The results favor a model in which the variability of the star is caused by variable circumstellar extinction. It is noted that the evidence is strong that variable envelope emission is the process responsible for variability in some T Tauri stars. Assuming that the condensations occult the star independently, the respective extinction laws are deduced by considering photometry for one of the large-amplitude variations and the small-amplitude changes; intrinsic colors for a G0V star are taken from Johnson (1966).

16. Food Additives and Hyperkinesis

ERIC Educational Resources Information Center

Wender, Ester H.

1977-01-01

The hypothesis that food additives are causally associated with hyperkinesis and learning disabilities in children is reviewed, and available data are summarized. Available from: American Medical Association 535 North Dearborn Street Chicago, Illinois 60610. (JG)

17. Smog control fuel additives

SciTech Connect

Lundby, W.

1993-06-29

A method is described of controlling, reducing or eliminating, ozone and related smog resulting from photochemical reactions between ozone and automotive or industrial gases comprising the addition of iodine or compounds of iodine to hydrocarbon-base fuels prior to or during combustion in an amount of about 1 part iodine per 240 to 10,000,000 parts fuel, by weight, to be accomplished by: (a) the addition of these inhibitors during or after the refining or manufacturing process of liquid fuels; (b) the production of these inhibitors for addition into fuel tanks, such as automotive or industrial tanks; or (c) the addition of these inhibitors into combustion chambers of equipment utilizing solid fuels for the purpose of reducing ozone.

18. Independent Schools: Landscape and Learnings.

ERIC Educational Resources Information Center

Oates, William A.

1981-01-01

Examines American independent schools (parochial, southern segregated, and private institutions) in terms of their funding, expenditures, changing enrollment patterns, teacher-student ratios, and societal functions. Journal available from Daedalus Subscription Department, 1172 Commonwealth Ave., Boston, MA 02132. (AM)

19. Technology for Independent Living: Sourcebook.

ERIC Educational Resources Information Center

Enders, Alexandra, Ed.

This sourcebook provides information for the practical implementation of independent living technology in the everyday rehabilitation process. "Information Services and Resources" lists databases, clearinghouses, networks, research and development programs, toll-free telephone numbers, consumer protection caveats, selected publications, and…

20. Modulation of additive and interactive effects by trial history revisited.

PubMed

Masson, Michael E J; Rabe, Maximilian M; Kliegl, Reinhold

2017-04-01

Masson and Kliegl (Journal of Experimental Psychology: Learning, Memory, and Cognition, 39, 898-914, 2013) reported evidence that the nature of the target stimulus on the previous trial of a lexical decision task modulates the effects of independent variables on the current trial, including additive versus interactive effects of word frequency and stimulus quality. In contrast, recent reanalyses of previously published data from experiments that, unlike the Masson and Kliegl experiments, did not include semantic priming as a factor, found no evidence for modulation of additive effects of frequency and stimulus quality by trial history (Balota, Aschenbrenner, & Yap, Journal of Experimental Psychology: Learning, Memory, and Cognition, 39, 1563-1571, 2013; O'Malley & Besner, Journal of Experimental Psychology: Learning, Memory, and Cognition, 34, 1400-1411, 2013). We report two experiments that included semantic priming as a factor and that attempted to replicate the modulatory effects found by Masson and Kliegl. In neither experiment was additivity of frequency and stimulus quality modulated by trial history, converging with the findings reported by Balota et al. and O'Malley and Besner. Other modulatory influences of trial history, however, were replicated in the new experiments and reflect potential trial-by-trial alterations in decision processes.

1. Experimental interference of independent photons.

PubMed

Kaltenbaek, Rainer; Blauensteiner, Bibiane; Zukowski, Marek; Aspelmeyer, Markus; Zeilinger, Anton

2006-06-23

Interference of photons emerging from independent sources is essential for modern quantum-information processing schemes, above all quantum repeaters and linear-optics quantum computers. We report an observation of nonclassical interference of two single photons originating from two independent, separated sources, which were actively synchronized with a rms timing jitter of 260 fs. The resulting (two-photon) interference visibility was (83+/-4)%.

2. Additive Manufacturing Infrared Inspection

NASA Technical Reports Server (NTRS)

2014-01-01

3. District nurses prescribing as nurse independent prescribers.

PubMed

Downer, Frances; Shepherd, Chew Kim

2010-07-01

Nurse prescribing has been established in the UK since 1994, however, limited focus has been placed on the experiences of district nurses adopting this additional role. This phenomenological study explores the experiences of district nurses prescribing as nurse independent prescribers across the West of Scotland. A qualitative Heideggarian approach examined the every-day experiences of independent prescribing among district nurses. A purposive sample was used and data collected using audio taped one-to-one informal interviews. The data was analysed thematically using Colaizzi's seven procedural steps. Overall these nurses reported that nurse prescribing was a predominantly positive experience. Participants identified improvements in patient care, job satisfaction, level of autonomy and role development. However, some of the participants indicated that issues such as support, record keeping, confidence and ongoing education are all major influences on prescribing practices.

4. Phenylethynyl Containing Reactive Additives

NASA Technical Reports Server (NTRS)

Connell, John W. (Inventor); Smith, Joseph G., Jr. (Inventor); Hergenrother, Paul M. (Inventor)

2002-01-01

Phenylethynyl containing reactive additives were prepared from aromatic diamine, containing phenylethvnvl groups and various ratios of phthalic anhydride and 4-phenylethynviphthalic anhydride in glacial acetic acid to form the imide in one step or in N-methyl-2-pvrrolidinone to form the amide acid intermediate. The reactive additives were mixed in various amounts (10% to 90%) with oligomers containing either terminal or pendent phenylethynyl groups (or both) to reduce the melt viscosity and thereby enhance processability. Upon thermal cure, the additives react and become chemically incorporated into the matrix and effect an increase in crosslink density relative to that of the host resin. This resultant increase in crosslink density has advantageous consequences on the cured resin properties such as higher glass transition temperature and higher modulus as compared to that of the host resin.

5. Phenylethynyl Containing Reactive Additives

NASA Technical Reports Server (NTRS)

Connell, John W. (Inventor); Smith, Joseph G., Jr. (Inventor); Hergenrother, Paul M. (Inventor)

2002-01-01

Phenylethynyl containing reactive additives were prepared from aromatic diamines containing phenylethynyl groups and various ratios of phthalic anhydride and 4-phenylethynylphthalic anhydride in glacial acetic acid to form the imide in one step or in N-methyl-2-pyrrolidi none to form the amide acid intermediate. The reactive additives were mixed in various amounts (10% to 90%) with oligomers containing either terminal or pendent phenylethynyl groups (or both) to reduce the melt viscosity and thereby enhance processability. Upon thermal cure, the additives react and become chemically incorporated into the matrix and effect an increase in crosslink density relative to that of the host resin. This resultant increase in crosslink density has advantageous consequences on the cured resin properties such as higher glass transition temperature and higher modulus as compared to that of the host resin.

6. A Boundary Mixture Approach to Violations of Conditional Independence

ERIC Educational Resources Information Center

Braeken, Johan

2011-01-01

Conditional independence is a fundamental principle in latent variable modeling and item response theory. Violations of this principle, commonly known as local item dependencies, are put in a test information perspective, and sharp bounds on these violations are defined. A modeling approach is proposed that makes use of a mixture representation of…

7. Resume Writing in Russia and the Newly Independent States

ERIC Educational Resources Information Center

Bowen, Betsy; Sapp, David Alan; Sargsyan, Nelly

2006-01-01

This article examines the teaching of resume writing at one university in Russia and several institutions in the Newly Independent States (NIS). The authors explore challenges including variable cultural norms for written versus oral communication, severe financial and material hardship in the educational sector, cultural discomfort with the norms…

8. Additives in plastics.

PubMed Central

Deanin, R D

1975-01-01

The polymers used in plastics are generally harmless. However, they are rarely used in pure form. In almost all commercial plastics, they are "compounded" with monomeric ingredients to improve their processing and end-use performance. In order of total volume used, these monomeric additives may be classified as follows: reinforcing fibers, fillers, and coupling agents; plasticizers; colorants; stabilizers (halogen stabilizers, antioxidants, ultraviolet absorbers, and biological preservatives); processing aids (lubricants, others, and flow controls); flame retardants, peroxides; and antistats. Some information is already available, and much more is needed, on potential toxicity and safe handling of these additives during processing and manufacture of plastics products. PMID:1175566

9. Additives in plastics.

PubMed

Deanin, R D

1975-06-01

The polymers used in plastics are generally harmless. However, they are rarely used in pure form. In almost all commercial plastics, they are "compounded" with monomeric ingredients to improve their processing and end-use performance. In order of total volume used, these monomeric additives may be classified as follows: reinforcing fibers, fillers, and coupling agents; plasticizers; colorants; stabilizers (halogen stabilizers, antioxidants, ultraviolet absorbers, and biological preservatives); processing aids (lubricants, others, and flow controls); flame retardants, peroxides; and antistats. Some information is already available, and much more is needed, on potential toxicity and safe handling of these additives during processing and manufacture of plastics products.

10. Variability in surface ECG morphology: signal or noise?

NASA Technical Reports Server (NTRS)

Smith, J. M.; Rosenbaum, D. S.; Cohen, R. J.

1988-01-01

Using data collected from canine models of acute myocardial ischemia, we investigated two issues of major relevance to electrocardiographic signal averaging: ECG epoch alignment, and the spectral characteristics of the beat-to-beat variability in ECG morphology. With initial digitization rates of 1 kHz, an iterative a posteriori matched filtering alignment scheme, and linear interpolation, we demonstrated that there is sufficient information in the body surface ECG to merit alignment to a precision of 0.1 msecs. Applying this technique to align QRS complexes and atrial pacing artifacts independently, we demonstrated that the conduction delay from atrial stimulus to ventricular activation may be so variable as to preclude using atrial pacing as an alignment mechanism, and that this variability in conduction time be modulated at the frequency of respiration and at a much lower frequency (0.02-0.03Hz). Using a multidimensional spectral technique, we investigated the beat-to-beat variability in ECG morphology, demonstrating that the frequency spectrum of ECG morphological variation reveals a readily discernable modulation at the frequency of respiration. In addition, this technique detects a subtle beat-to-beat alternation in surface ECG morphology which accompanies transient coronary artery occlusion. We conclude that physiologically important information may be stored in the variability in the surface electrocardiogram, and that this information is lost by conventional averaging techniques.

11. Reconstruction of Past Climatic Variability

DTIC Science & Technology

1976-03-01

United States. Extensive tree-ring sampling would be required In those areas to validate the revised hypothesis. In a similar vein, corn and wheat ...1910-1961. The tree-ring amplitudes were derived from the aforementioned 49-station network and formed the set of independent variables. The wheat ...Indices were based upon a weighted average of wheat production in North Dakota, South Dakota, Nebraska, Kansas, and Oklahoma, and it is unclear

12. Biobased lubricant additives

Technology Transfer Automated Retrieval System (TEKTRAN)

Fully biobased lubricants are those formulated using all biobased ingredients, i.e. biobased base oils and biobased additives. Such formulations provide the maximum environmental, safety, and economic benefits expected from a biobased product. Currently, there are a number of biobased base oils that...

13. More Than Additional Space...

ERIC Educational Resources Information Center

CEFP Journal, 1973

1973-01-01

A much needed addition to the Jamestown Elementary School turned out to be more than an expansion of walls for more space. A new educational program, a limited budget, and a short time line were tackled on a team approach basis and were successfully resolved. (Author)

14. New opportunities seen for independents

SciTech Connect

1990-10-22

The collapse of gas and oil prices in the mid-1980s significantly reduced the number of independent exploration companies. At the same time, a fundamental shift occurred among major oil companies as they allocated their exploration budgets toward international operations and made major production purchases. Several large independents also embraced a philosophy of budget supplementation through joint venture partnership arrangements. This has created a unique and unusual window of opportunity for the smaller independents (defined for this article as exploration and production companies with a market value of less than \$1 billion) to access the extensive and high quality domestic prospect inventories of the major and large independent oil and gas companies and to participate in the search for large reserve targets on attractive joint venture terms. Participation in these types of joint ventures, in conjunction with internally generated plays selected through the use of today's advanced technology (computer-enhanced, high-resolution seismic; horizontal drilling; etc.) and increasing process for oil and natural gas, presents the domestic exploration-oriented independent with an attractive money-making opportunity for the 1990s.

15. Regression with Empirical Variable Selection: Description of a New Method and Application to Ecological Datasets

PubMed Central

Goodenough, Anne E.; Hart, Adam G.; Stafford, Richard

2012-01-01

Despite recent papers on problems associated with full-model and stepwise regression, their use is still common throughout ecological and environmental disciplines. Alternative approaches, including generating multiple models and comparing them post-hoc using techniques such as Akaike's Information Criterion (AIC), are becoming more popular. However, these are problematic when there are numerous independent variables and interpretation is often difficult when competing models contain many different variables and combinations of variables. Here, we detail a new approach, REVS (Regression with Empirical Variable Selection), which uses all-subsets regression to quantify empirical support for every independent variable. A series of models is created; the first containing the variable with most empirical support, the second containing the first variable and the next most-supported, and so on. The comparatively small number of resultant models (n = the number of predictor variables) means that post-hoc comparison is comparatively quick and easy. When tested on a real dataset – habitat and offspring quality in the great tit (Parus major) – the optimal REVS model explained more variance (higher R2), was more parsimonious (lower AIC), and had greater significance (lower P values), than full, stepwise or all-subsets models; it also had higher predictive accuracy based on split-sample validation. Testing REVS on ten further datasets suggested that this is typical, with R2 values being higher than full or stepwise models (mean improvement = 31% and 7%, respectively). Results are ecologically intuitive as even when there are several competing models, they share a set of “core” variables and differ only in presence/absence of one or two additional variables. We conclude that REVS is useful for analysing complex datasets, including those in ecology and environmental disciplines. PMID:22479605

16. Regression with empirical variable selection: description of a new method and application to ecological datasets.

PubMed

Goodenough, Anne E; Hart, Adam G; Stafford, Richard

2012-01-01

Despite recent papers on problems associated with full-model and stepwise regression, their use is still common throughout ecological and environmental disciplines. Alternative approaches, including generating multiple models and comparing them post-hoc using techniques such as Akaike's Information Criterion (AIC), are becoming more popular. However, these are problematic when there are numerous independent variables and interpretation is often difficult when competing models contain many different variables and combinations of variables. Here, we detail a new approach, REVS (Regression with Empirical Variable Selection), which uses all-subsets regression to quantify empirical support for every independent variable. A series of models is created; the first containing the variable with most empirical support, the second containing the first variable and the next most-supported, and so on. The comparatively small number of resultant models (n = the number of predictor variables) means that post-hoc comparison is comparatively quick and easy. When tested on a real dataset--habitat and offspring quality in the great tit (Parus major)--the optimal REVS model explained more variance (higher R(2)), was more parsimonious (lower AIC), and had greater significance (lower P values), than full, stepwise or all-subsets models; it also had higher predictive accuracy based on split-sample validation. Testing REVS on ten further datasets suggested that this is typical, with R(2) values being higher than full or stepwise models (mean improvement = 31% and 7%, respectively). Results are ecologically intuitive as even when there are several competing models, they share a set of "core" variables and differ only in presence/absence of one or two additional variables. We conclude that REVS is useful for analysing complex datasets, including those in ecology and environmental disciplines.

17. Variables related to romanticism and self-esteem in pregnant teenagers.

PubMed

Medora, N P; Goldstein, A; von der Hellen, C

1993-01-01

In this study, the Dean Romanticism Scale and the Bachman Self-esteem Scale were administered to 121 teenagers between the ages of 12 and 19 in Southern California to investigate their degree of romanticism and self-esteem. The study also explored whether there was any relationship between the dependent variables of romanticism and self-esteem and ten independent variables--age, race, place of residence during pregnancy, age when first sexual intercourse occurred, age when pregnancy occurred, incidence of sexual abuse, incidence of abortion, adoption considerations, whether the subject was currently sexually active, and whether the teenager planned to have a child with the father of the baby. The results indicated that two variables were significantly related to feelings of romanticism--adoption considerations and whether the adolescent planned to have a child with the baby's father. In addition, two variables were significantly related to self-esteem--the incidence of sexual abuse and the incidence of abortion.

18. Interactively variable isotropic resolution in computed tomography.

PubMed

Lapp, Robert M; Kyriakou, Yiannis; Kachelriess, Marc; Wilharm, Sylvia; Kalender, Willi A

2008-05-21

An individual balancing between spatial resolution and image noise is necessary to fulfil the diagnostic requirements in medical CT imaging. In order to change influencing parameters, such as reconstruction kernel or effective slice thickness, additional raw-data-dependent image reconstructions have to be performed. Therefore, the noise versus resolution trade-off is time consuming and not interactively applicable. Furthermore, isotropic resolution, expressed by an equivalent point spread function (PSF) in every spatial direction, is important for the undistorted visualization and quantitative evaluation of small structures independent of the viewing plane. Theoretically, isotropic resolution can be obtained by matching the in-plane and through-plane resolution with the aforementioned parameters. Practically, however, the user is not assisted in doing so by current reconstruction systems and therefore isotropic resolution is not commonly achieved, in particular not at the desired resolution level. In this paper, an integrated approach is presented for equalizing the in-plane and through-plane spatial resolution by image filtering. The required filter kernels are calculated from previously measured PSFs in x/y- and z-direction. The concepts derived are combined with a variable resolution filtering technique. Both approaches are independent of CT raw data and operate only on reconstructed images which allows for their application in real time. Thereby, the aim of interactively variable, isotropic resolution is achieved. Results were evaluated quantitatively by measuring PSFs and image noise, and qualitatively by comparing the images to direct reconstructions regarded as the gold standard. Filtered images matched direct reconstructions with arbitrary reconstruction kernels with standard deviations in difference images of typically between 1 and 17 HU. Isotropic resolution was achieved within 5% of the selected resolution level. Processing times of 20-100 ms per frame

19. Benefits of Stimulus Exposure: Developmental Learning Independent of Task Performance

PubMed Central

Green, David B.; Ohlemacher, Jocelyn; Rosen, Merri J.

2016-01-01

Perceptual learning (training-induced performance improvement) can be elicited by task-irrelevant stimulus exposure in humans. In contrast, task-irrelevant stimulus exposure in animals typically disrupts perception in juveniles while causing little to no effect in adults. This may be due to the extent of exposure, which is brief in humans while chronic in animals. Here we assessed the effects of short bouts of passive stimulus exposure on learning during development in gerbils, compared with non-passive stimulus exposure (i.e., during testing). We used prepulse inhibition of the acoustic startle response, a method that can be applied at any age, to measure gap detection thresholds across four age groups, spanning development. First, we showed that both gap detection thresholds and gap detection learning across sessions displayed a long developmental trajectory, improving throughout the juvenile period. Additionally, we demonstrated larger within- and across-animal performance variability in younger animals. These results are generally consistent with results in humans, where there are extended developmental trajectories for both the perception of temporally-varying signals, and the effects of perceptual training, as well as increased variability and poorer performance consistency in children. We then chose an age (mid-juveniles) that displayed clear learning over sessions in order to assess effects of brief passive stimulus exposure on this learning. We compared learning in mid-juveniles exposed to either gap detection testing (gaps paired with startles) or equivalent gap exposure without testing (gaps alone) for three sessions. Learning was equivalent in both these groups and better than both naïve age-matched animals and controls receiving no gap exposure but only startle testing. Thus, short bouts of exposure to gaps independent of task performance is sufficient to induce learning at this age, and is as effective as gap detection testing. PMID:27378837

20. Suspended graphene variable capacitor

NASA Astrophysics Data System (ADS)

AbdelGhany, M.; Mahvash, F.; Mukhopadhyay, M.; Favron, A.; Martel, R.; Siaj, M.; Szkopek, T.

2016-12-01

Electromechanical variable capacitors, or varactors, find a wide range of applications including sensing applications and the tuning of electrical circuit resonance. We demonstrate a nano-electromechanical graphene varactor, a variable capacitor wherein the capacitance is tuned by voltage controlled deflection of a dense array of suspended graphene membranes. The low flexural rigidity of graphene monolayers is exploited to achieve low actuation voltage and high tunable capacitance density in an ultra-thin structure. Large arrays comprising thousands of suspensions were fabricated to give a tunable capacitance of over 10 pF mm-2. This capacitance density suggests that graphene offers a potential solution to the challenge of reducing the size of micro-electromechanical systems (MEMS). A capacitance tuning of 55% was achieved with a 10 V actuating voltage, exceeding the 50% tuning limit of Hookean parallel plate pull-in without the use of complex mechanical schemes that occupy substrate area. Capacitor behavior was investigated experimentally, and described by a simple theoretical model. Mechanical properties of the graphene membranes were measured independently using atomic force microscopy. We present a comparison of state-of-the-art MEMS and graphene varactors. The quality factor of graphene varactors is limited by graphene sheet resistance, pull-in voltage can be improved with more aggressive scaling, while the power handling and cycling stability of graphene varactors remains unknown.

1. Vinyl capped addition polyimides

NASA Technical Reports Server (NTRS)

Vannucci, Raymond D. (Inventor); Malarik, Diane C. (Inventor); Delvigs, Peter (Inventor)

1991-01-01

Polyimide resins (PMR) are generally useful where high strength and temperature capabilities are required (at temperatures up to about 700 F). Polyimide resins are particularly useful in applications such as jet engine compressor components, for example, blades, vanes, air seals, air splitters, and engine casing parts. Aromatic vinyl capped addition polyimides are obtained by reacting a diamine, an ester of tetracarboxylic acid, and an aromatic vinyl compound. Low void materials with improved oxidative stability when exposed to 700 F air may be fabricated as fiber reinforced high molecular weight capped polyimide composites. The aromatic vinyl capped polyimides are provided with a more aromatic nature and are more thermally stable than highly aliphatic, norbornenyl-type end-capped polyimides employed in PMR resins. The substitution of aromatic vinyl end-caps for norbornenyl end-caps in addition polyimides results in polymers with improved oxidative stability.

2. The Independent Technical Analysis Process

SciTech Connect

Duberstein, Corey A.; Ham, Kenneth D.; Dauble, Dennis D.; Johnson, Gary E.

2007-04-13

The Bonneville Power Administration (BPA) contracted with the Pacific Northwest National Laboratory (PNNL) to provide technical analytical support for system-wide fish passage information (BPA Project No. 2006-010-00). The goal of this project was to produce rigorous technical analysis products using independent analysts and anonymous peer reviewers. In the past, regional parties have interacted with a single entity, the Fish Passage Center to access the data, analyses, and coordination related to fish passage. This project provided an independent technical source for non-routine fish passage analyses while allowing routine support functions to be performed by other well-qualified entities.

3. Electrophilic addition of astatine

SciTech Connect

Norseev, Yu.V.; Vasaros, L.; Nhan, D.D.; Huan, N.K.

1988-03-01

It has been shown for the first time that astatine is capable of undergoing addition reactions to unsaturated hydrocarbons. A new compound of astatine, viz., ethylene astatohydrin, has been obtained, and its retention numbers of squalane, Apiezon, and tricresyl phosphate have been found. The influence of various factors on the formation of ethylene astatohydrin has been studied. It has been concluded on the basis of the results obtained that the univalent cations of astatine in an acidic medium is protonated hypoastatous acid.

4. Functional Generalized Additive Models.

PubMed

McLean, Mathew W; Hooker, Giles; Staicu, Ana-Maria; Scheipl, Fabian; Ruppert, David

2014-01-01

We introduce the functional generalized additive model (FGAM), a novel regression model for association studies between a scalar response and a functional predictor. We model the link-transformed mean response as the integral with respect to t of F{X(t), t} where F(·,·) is an unknown regression function and X(t) is a functional covariate. Rather than having an additive model in a finite number of principal components as in Müller and Yao (2008), our model incorporates the functional predictor directly and thus our model can be viewed as the natural functional extension of generalized additive models. We estimate F(·,·) using tensor-product B-splines with roughness penalties. A pointwise quantile transformation of the functional predictor is also considered to ensure each tensor-product B-spline has observed data on its support. The methods are evaluated using simulated data and their predictive performance is compared with other competing scalar-on-function regression alternatives. We illustrate the usefulness of our approach through an application to brain tractography, where X(t) is a signal from diffusion tensor imaging at position, t, along a tract in the brain. In one example, the response is disease-status (case or control) and in a second example, it is the score on a cognitive test. R code for performing the simulations and fitting the FGAM can be found in supplemental materials available online.

5. Attitude Towards Physics and Additional Mathematics Achievement Towards Physics Achievement

ERIC Educational Resources Information Center

Veloo, Arsaythamby; Nor, Rahimah; Khalid, Rozalina

2015-01-01

The purpose of this research is to identify the difference in students' attitude towards Physics and Additional Mathematics achievement based on gender and relationship between attitudinal variables towards Physics and Additional Mathematics achievement with achievement in Physics. This research focused on six variables, which is attitude towards…

6. Field Independence: Reviewing the Evidence

ERIC Educational Resources Information Center

Evans, Carol; Richardson, John T. E.; Waring, Michael

2013-01-01

Background: The construct of ?eld independence (FI) remains one of the most widely cited notions in research on cognitive style and on learning and instruction more generally. However, a great deal of confusion continues to exist around the de?nition of FI, its measurement, and the interpretation of research results, all of which have served to…

7. Content Independence in Multimedia Databases.

ERIC Educational Resources Information Center

de Vries, Arjen P.

2001-01-01

Investigates the role of data management in multimedia digital libraries, and its implications for the design of database management systems. Introduces the notions of content abstraction and content independence. Proposes a blueprint of a new class of database technology, which supports the basic functionality for the management of both content…

8. Independent Study Course Development Costs.

ERIC Educational Resources Information Center

Wright, Clayton R.

1988-01-01

Discusses actual costs for developing independent study print courses for use in learning centers or for distance delivery, and presents a resource allocation guideline based on figures from Grant MacEwan Community College (Alberta). Topics discussed include the course writer/developer, clerical support, copyright clearance, instructional design,…

9. Boston: Cradle of American Independence

ERIC Educational Resources Information Center

Community College Journal, 2004

2004-01-01

The 2005 American Association of Community Colleges Annual Convention will be held April 6-9 in Boston. While thoroughly modern, the iconic city's identity is firmly rooted in the past. As the cradle of American independence, Boston's long history is an integral part of the American fabric. Adams, Revere, Hancock are more than historical figures;…

10. Scales of Independent Behavior (SIB).

ERIC Educational Resources Information Center

Thomas, Paulette J.

1990-01-01

Designed for use with individuals ages 3 months to 44 years, the Scales of Independent Behavior (SIB) measure adaptive behavior and problem behaviors in such areas as motor skills, social interaction, language, personal self-care, punctuality, destructiveness, and inattention. This paper describes the SIB's administration, scoring,…

ERIC Educational Resources Information Center

Truby, Dana

2012-01-01

Teachers know that establishing a robust independent reading program takes more than giving kids a little quiet time after lunch. But how do they set up a program that will maximize their students' gains? Teachers have to know their students' reading levels inside and out, help them find just-right books, and continue to guide them during…

12. Will Independent Junior Colleges Survive?

ERIC Educational Resources Information Center

Blai, Boris, Jr.

This essay reviews the current status of private independent junior colleges in the United States. Several studies and innovative programs are cited. Because private junior colleges face shrinking enrollments and diminished funding for instruction, services, and activities, they must now stress cost-effectiveness and practical financial management…

13. Haptic Tracking Permits Bimanual Independence

ERIC Educational Resources Information Center

Rosenbaum, David A.; Dawson, Amanda A.; Challis, John H.

2006-01-01

This study shows that in a novel task--bimanual haptic tracking--neurologically normal human adults can move their 2 hands independently for extended periods of time with little or no training. Participants lightly touched buttons whose positions were moved either quasi-randomly in the horizontal plane by 1 or 2 human drivers (Experiment 1), in…

14. Time as a dynamical variable

NASA Astrophysics Data System (ADS)

Thron, Christopher

2017-01-01

Since the time of Galileo, the equations of physics have expressed dynamical variables such as particle position or electromagnetic field strength as functions of time. In this paper, we argue that this assumption reflects observational bias, and that there are many good reasons for viewing time also as a dynamical variable. We hypothesize that the spacetime universe is an outcome of a process, rather than a process unfolding in time. This new viewpoint gives rise to a physical interpretation of the wavefunction as a complex vibrational amplitude in a non-spacetime independent variable. It resolves quantum mechanical paradoxes involving wavefunction entanglement, and gives a much simpler solution to the problem of wavefunction collapse than the many-worlds interpretation. The Born rule is also shown to be a natural consequence. We also show that small deviations from conventional quantum probabilities are predicted.

15. Siloxane containing addition polyimides

NASA Technical Reports Server (NTRS)

Maudgal, S.; St. Clair, T. L.

1984-01-01

Addition polyimide oligomers have been synthesized from bis(gamma-aminopropyl) tetramethyldisiloxane and 3, 3', 4, 4'-benzophenonetetracarboxylic dianhydride using a variety of latent crosslinking groups as endcappers. The prepolymers were isolated and characterized for solubility (in amide, chlorinated and ether solvents), melt flow and cure properties. The most promising systems, maleimide and acetylene terminated prepolymers, were selected for detailed study. Graphite cloth reinforced composites were prepared and properties compared with those of graphite/Kerimid 601, a commercially available bismaleimide. Mixtures of the maleimide terminated system with Kerimid 601, in varying proportions, were also studied.

16. African American Race is an Independent Risk Factor in Survival from Initially Diagnosed Localized Breast Cancer

PubMed Central

Wieder, Robert; Shafiq, Basit; Adam, Nabil

2016-01-01

BACKGROUND: African American race negatively impacts survival from localized breast cancer but co-variable factors confound the impact. METHODS: Data sets were analyzed from the Surveillance, Epidemiology and End Results (SEER) directories from 1973 to 2011 consisting of patients with designated diagnosis of breast adenocarcinoma, race as White or Caucasian, Black or African American, Asian, American Indian or Alaskan Native, Native Hawaiian or Pacific Islander, age, stage I, II or III, grade 1, 2 or 3, estrogen receptor or progesterone receptor positive or negative, marital status as single, married, separated, divorced or widowed and laterality as right or left. The Cox Proportional Hazards Regression model was used to determine hazard ratios for survival. Chi square test was applied to determine the interdependence of variables found significant in the multivariable Cox Proportional Hazards Regression analysis. Cells with stratified data of patients with identical characteristics except African American or Caucasian race were compared. RESULTS: Age, stage, grade, ER and PR status and marital status significantly co-varied with race and with each other. Stratifications by single co-variables demonstrated worse hazard ratios for survival for African Americans. Stratification by three and four co-variables demonstrated worse hazard ratios for survival for African Americans in most subgroupings with sufficient numbers of values. Differences in some subgroupings containing poor prognostic co-variables did not reach significance, suggesting that race effects may be partly overcome by additional poor prognostic indicators. CONCLUSIONS: African American race is a poor prognostic indicator for survival from breast cancer independent of 6 associated co-variables with prognostic significance. PMID:27698895

17. Platelet additive solution - electrolytes.

PubMed

Azuma, Hiroshi; Hirayama, Junichi; Akino, Mitsuaki; Ikeda, Hisami

2011-06-01

Recent attention to solutions that replace most or all plasma in platelet concentrates, while maintaining satisfactory platelet function, is motivated by the potential of plasma reduction or depletion to mitigate various transfusion-related adverse events. This report considers the electrolytic composition of previously described platelet additive solutions, in order to draw general conclusions about what is required for platelet function and longevity. The optimal concentrations of Na(+) and Cl(-) are 69-115 mM. The presence of both K(+) and Mg(2+) in platelet suspension at nearly physiological concentrations (3-5mM and 1.5-3mM, respectively) is indispensable for good preservation capacity because both electrolytes are required to prevent platelet activation. In contrast to K(+) and Mg(2+), Ca(2+) may not be important because no free Ca(2+) is available in M-sol, which showed excellent platelet preservation capacity at less than 5% plasma concentration. The importance of bicarbonate (approximately 40 mM) can be recognized when the platelets are suspended in additive solution under less than 5% residual plasma concentration.

18. Photonic variable delay devices based on optical birefringence

NASA Technical Reports Server (NTRS)

Yao, X. Steve (Inventor)

2005-01-01

Optical variable delay devices for providing variable true time delay to multiple optical beams simultaneously. A ladder-structured variable delay device comprises multiple basic building blocks stacked on top of each other resembling a ladder. Each basic building block has two polarization beamsplitters and a polarization rotator array arranged to form a trihedron; Controlling an array element of the polarization rotator array causes a beam passing through the array element either going up to a basic building block above it or reflect back towards a block below it. The beams going higher on the ladder experience longer optical path delay. An index-switched optical variable delay device comprises of many birefringent crystal segments connected with one another, with a polarization rotator array sandwiched between any two adjacent crystal segments. An array element in the polarization rotator array controls the polarization state of a beam passing through the element, causing the beam experience different refractive indices or path delays in the following crystal segment. By independently control each element in each polarization rotator array, variable optical path delays of each beam can be achieved. Finally, an index-switched variable delay device and a ladder-structured variable device are cascaded to form a new device which combines the advantages of the two individual devices. This programmable optic device has the properties of high packing density, low loss, easy fabrication, and virtually infinite bandwidth. The device is inherently two dimensional and has a packing density exceeding 25 lines/cm2. The delay resolution of the device is on the order of a femtosecond (one micron in space) and the total delay exceeds 10 nanosecond. In addition, the delay is reversible so that the same delay device can be used for both antenna transmitting and receiving.

19. Gap junction- and hemichannel-independent actions of connexins

PubMed Central

Jiang, Jean X.; Gu, Sumin

2007-01-01

Connexins have been known to be the protein building blocks of gap junctions and mediate cell–cell communication. In contrast to the conventional dogma, recent evidence suggests that in addition to forming gap junction channels, connexins possess gap junction-independent functions. One important gap junction-independent function for connexins is to serve as the major functional component for hemichannels, the un-apposed halves of gap junctions. Hemichannels, as independent functional units, play roles that are different from that of gap junctions in the cell. The other functions of connexins appear to be gap junction- and hemichannel-independent. Published studies implicate the latter functions of connexins in cell growth, differentiation, tumorigenicity, injury, and apoptosis, although the mechanistic aspects of these actions remain largely unknown. In this review, gap junction- and hemichannel-independent functions of connexins are summarized, and the molecular mechanisms underlying these connexin functions are speculated and discussed. PMID:15955305

20. Predicting Ecologically Important Vegetation Variables from Remotely Sensed Optical/Radar Data Using Neural Networks

NASA Technical Reports Server (NTRS)

Kimes, Daniel S.; Nelson, Ross F.

1998-01-01

A number of satellite sensor systems will collect large data sets of the Earth's surface during NASA's Earth Observing System (EOS) era. Efforts are being made to develop efficient algorithms that can incorporate a wide variety of spectral data and ancillary data in order to extract vegetation variables required for global and regional studies of ecosystem processes, biosphere-atmosphere interactions, and carbon dynamics. These variables are, for the most part, continuous (e.g. biomass, leaf area index, fraction of vegetation cover, vegetation height, vegetation age, spectral albedo, absorbed photosynthetic active radiation, photosynthetic efficiency, etc.) and estimates may be made using remotely sensed data (e.g. nadir and directional optical wavelengths, multifrequency radar backscatter) and any other readily available ancillary data (e.g., topography, sun angle, ground data, etc.). Using these types of data, neural networks can: 1) provide accurate initial models for extracting vegetation variables when an adequate amount of data is available; 2) provide a performance standard for evaluating existing physically-based models; 3) invert multivariate, physically based models; 4) in a variable selection process, identify those independent variables which best infer the vegetation variable(s) of interest; and 5) incorporate new data sources that would be difficult or impossible to use with conventional techniques. In addition, neural networks employ a more powerful and adaptive nonlinear equation form as compared to traditional linear, index transformations, and simple nonlinear analyses. These neural networks attributes are discussed in the context of the authors' investigations of extracting vegetation variables of ecological interest.

1. Additive composition, for gasoline

SciTech Connect

Vataru, M.

1989-01-10

An admixture is described that comprises Diesel fuel and an additive composition added thereto which is between about 0.05 to about 2.0 percent by weight of the fuel, the composition comprising: (a) between about 0.05 and 25% relative weight parts of an organic peroxide, and (b) between about 0.1 and 25% relative weight parts of detergent selected from the component group that consists of: (i) fatty amines; (ii) ethoxylated and propoxylated derivatives of fatty amines; (iii) fatty diamines; (iv) fatty imidazlines; (v) polymeric amines and derivatives thereof; (vi) combination of one or more of the (i) through (v) components with carboxylic acid or acids having from three to forth carbon atoms, (c) from about 99.0 to about 50% by weight of a hydrocarbon solvent.

SciTech Connect

Wechsler, R.J.; Brennan, R.E.

1982-07-01

Nine cases of teardrop bladder (TDB) seen at excretory urography are presented. In some of these patients, the iliopsoas muscles were at the upper limit of normal in size, and additional evaluation of the perivesical structures with computed tomography (CT) was necessary. CT demonstrated only hypertrophied muscles with or without perivesical fat. The psoas muscles and pelvic width were measured in 8 patients and compared with the measurements of a control group of males without TDB. Patients with TDB had large iliopsoas muscles and narrow pelves compared with the control group. The psoas muscle width/pelvic width ratio was significantly greater (p < 0.0005) in patients with TDB than in the control group, with values of 1.04 + 0.05 and 0.82 + 0.09, respectively. It is concluded that TDB is not an uncommon normal variant in black males. Both iliopsoas muscle hypertrophy and a narrow pelvis are factors that predispose a patient to TDB.

3. Perspectives on Additive Manufacturing

NASA Astrophysics Data System (ADS)

Bourell, David L.

2016-07-01

Additive manufacturing (AM) has skyrocketed in visibility commercially and in the public sector. This article describes the development of this field from early layered manufacturing approaches of photosculpture, topography, and material deposition. Certain precursors to modern AM processes are also briefly described. The growth of the field over the last 30 years is presented. Included is the standard delineation of AM technologies into seven broad categories. The economics of AM part generation is considered, and the impacts of the economics on application sectors are described. On the basis of current trends, the future outlook will include a convergence of AM fabricators, mass-produced AM fabricators, enabling of topology optimization designs, and specialization in the AM legal arena. Long-term developments with huge impact are organ printing and volume-based printing.

4. Sewage sludge additive

NASA Technical Reports Server (NTRS)

Kalvinskas, J. J.; Mueller, W. A.; Ingham, J. D. (Inventor)

1980-01-01

The additive is for a raw sewage treatment process of the type where settling tanks are used for the purpose of permitting the suspended matter in the raw sewage to be settled as well as to permit adsorption of the dissolved contaminants in the water of the sewage. The sludge, which settles down to the bottom of the settling tank is extracted, pyrolyzed and activated to form activated carbon and ash which is mixed with the sewage prior to its introduction into the settling tank. The sludge does not provide all of the activated carbon and ash required for adequate treatment of the raw sewage. It is necessary to add carbon to the process and instead of expensive commercial carbon, coal is used to provide the carbon supplement.

5. Construct Relevant and Irrelevant Variables in Math Problem Solving Assessment

ERIC Educational Resources Information Center

Birk, Lisa E.

2013-01-01

In this study, I examined the relation between various construct relevant and irrelevant variables and a math problem solving assessment. I used independent performance measures representing the variables of mathematics content knowledge, general ability, and reading fluency. Non-performance variables included gender, socioeconomic status,…

6. 8. Interior view, basement, west addition, looking northeast towards (exterior) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Interior view, basement, west addition, looking northeast towards (exterior) west wall of original section, bottom corbel of chimney base visible along wall - Latham House, 1200 North Quaker Lane, Alexandria, Independent City, VA

7. Steps to Independent Living Series.

ERIC Educational Resources Information Center

Lobb, Nancy

This set of six activity books and a teacher's guide is designed to help students from eighth grade to adulthood with special needs to learn independent living skills. The activity books have a reading level of 2.5 and address: (1) "How to Get Well When You're Sick or Hurt," including how to take a temperature, see a doctor, and use medicines…

8. Do rats learn conditional independence?

PubMed Central

Timberlake, William

2017-01-01

If acquired associations are to accurately represent real relevance relations, there is motivation for the hypothesis that learning will, in some circumstances, be more appropriately modelled, not as direct dependence, but as conditional independence. In a serial compound conditioning experiment, two groups of rats were presented with a conditioned stimulus (CS1) that imperfectly (50%) predicted food, and was itself imperfectly predicted by a CS2. Groups differed in the proportion of CS2 presentations that were ultimately followed by food (25% versus 75%). Thus, the information presented regarding the relevance of CS2 to food was ambiguous between direct dependence and conditional independence (given CS1). If rats learnt that food was conditionally independent of CS2, given CS1, subjects of both groups should thereafter respond similarly to CS2 alone. Contrary to the conditionality hypothesis, subjects attended to the direct food predictability of CS2, suggesting that rats treat even distal stimuli in a CS sequence as immediately relevant to food, not conditional on an intermediate stimulus. These results urge caution in representing indirect associations as conditional associations, accentuate the theoretical weight of the Markov condition in graphical models, and challenge theories to articulate the conditions under which animals are expected to learn conditional associations, if ever. PMID:28386451

9. Additive lattice kirigami.

PubMed

Castle, Toen; Sussman, Daniel M; Tanis, Michael; Kamien, Randall D

2016-09-01

Kirigami uses bending, folding, cutting, and pasting to create complex three-dimensional (3D) structures from a flat sheet. In the case of lattice kirigami, this cutting and rejoining introduces defects into an underlying 2D lattice in the form of points of nonzero Gaussian curvature. A set of simple rules was previously used to generate a wide variety of stepped structures; we now pare back these rules to their minimum. This allows us to describe a set of techniques that unify a wide variety of cut-and-paste actions under the rubric of lattice kirigami, including adding new material and rejoining material across arbitrary cuts in the sheet. We also explore the use of more complex lattices and the different structures that consequently arise. Regardless of the choice of lattice, creating complex structures may require multiple overlapping kirigami cuts, where subsequent cuts are not performed on a locally flat lattice. Our additive kirigami method describes such cuts, providing a simple methodology and a set of techniques to build a huge variety of complex 3D shapes.

10. Ceramics with Different Additives

NASA Astrophysics Data System (ADS)

Wang, Juanjuan; Feng, Lajun; Lei, Ali; Zhao, Kang; Yan, Aijun

2014-09-01

Li2CO3, MgCO3, BaCO3, and Bi2O3 dopants were introduced into CaCu3Ti4O12 (CCTO) ceramics in order to improve the dielectric properties. The CCTO ceramics were prepared by conventional solid-state reaction method. The phase structure, microstructure, and dielectric behavior were carefully investigated. The pure structure without any impurity phases can be confirmed by the x-ray diffraction patterns. Scanning Electron Microscopy (SEM) analysis illuminated that the grains of Ca0.90Li0.20Cu3Ti4O12 ceramics were greater than that of pure CCTO. It was important for the properties of the CCTO ceramics to study the additives in complex impedance spectroscopy. It was found that the Ca0.90Li0.20Cu3Ti4O12 ceramics had the higher permittivity (>45000), the lower dielectric loss (<0.025) than those of CCTO at 1 kHz at room temperature and good temperature stability from -30 to 75 °C.

11. Additive lattice kirigami

PubMed Central

Castle, Toen; Sussman, Daniel M.; Tanis, Michael; Kamien, Randall D.

2016-01-01

Kirigami uses bending, folding, cutting, and pasting to create complex three-dimensional (3D) structures from a flat sheet. In the case of lattice kirigami, this cutting and rejoining introduces defects into an underlying 2D lattice in the form of points of nonzero Gaussian curvature. A set of simple rules was previously used to generate a wide variety of stepped structures; we now pare back these rules to their minimum. This allows us to describe a set of techniques that unify a wide variety of cut-and-paste actions under the rubric of lattice kirigami, including adding new material and rejoining material across arbitrary cuts in the sheet. We also explore the use of more complex lattices and the different structures that consequently arise. Regardless of the choice of lattice, creating complex structures may require multiple overlapping kirigami cuts, where subsequent cuts are not performed on a locally flat lattice. Our additive kirigami method describes such cuts, providing a simple methodology and a set of techniques to build a huge variety of complex 3D shapes. PMID:27679822

12. Dimensionless numbers in additive manufacturing

NASA Astrophysics Data System (ADS)

Mukherjee, T.; Manvatkar, V.; De, A.; DebRoy, T.

2017-02-01

The effects of many process variables and alloy properties on the structure and properties of additively manufactured parts are examined using four dimensionless numbers. The structure and properties of components made from 316 Stainless steel, Ti-6Al-4V, and Inconel 718 powders for various dimensionless heat inputs, Peclet numbers, Marangoni numbers, and Fourier numbers are studied. Temperature fields, cooling rates, solidification parameters, lack of fusion defects, and thermal strains are examined using a well-tested three-dimensional transient heat transfer and fluid flow model. The results show that lack of fusion defects in the fabricated parts can be minimized by strengthening interlayer bonding using high values of dimensionless heat input. The formation of harmful intermetallics such as laves phases in Inconel 718 can be suppressed using low heat input that results in a small molten pool, a steep temperature gradient, and a fast cooling rate. Improved interlayer bonding can be achieved at high Marangoni numbers, which results in vigorous circulation of liquid metal, larger pool dimensions, and greater depth of penetration. A high Fourier number ensures rapid cooling, low thermal distortion, and a high ratio of temperature gradient to the solidification growth rate with a greater tendency of plane front solidification.

13. Effects of SO/sub 2/ shielding gas additions on GTA weld shape

SciTech Connect

Heiple, C.R.; Burgardt, P.

1985-06-01

Substantial increases in GTA weld depth/width ratio resulted from small additions of sulfur dioxide (SO/sub 2/) to the torch shielding gas when welding two stainless steels. The improvement was demonstrated on both Types 304 and 21-6-9 austenitic stainless steels, but would be expected for iron-base alloys generally. The weld pool shape achieved was essentially independent of variations in both SO/sub 2/ content of the torch gas and base metal composition when SO/sub 2/ in the shielding gas was in the range of 500 to 1400 ppm. With 700 ppm SO/sub 2/ in the torch gas, less than 30 ppm sulfur was added to an autogenous weld bead. For alloys where this additional sulfur can be tolerated and appropriate measures can be taken to handle the toxic SO/sub 2/, this technique offers a promising way to improve GTA weld joint penetration while suppressing variable penetration.

14. Mass-independent isotope effects.

PubMed

Buchachenko, Anatoly L

2013-02-28

Three fundamental properties of atomic nuclei-mass, spin (and related magnetic moment), and volume-are the source of isotope effects. The mostly deserved and popular, with almost hundred-year history, is the mass-dependent isotope effect. The first mass-independent isotope effect which chemically discriminates isotopes by their nuclear spins and nuclear magnetic moments rather than by their masses was detected in 1976. It was named as the magnetic isotope effect because it is controlled by magnetic interaction, i.e., electron-nuclear hyperfine coupling in the paramagnetic species, the reaction intermediates. The effect follows from the universal physical property of chemical reactions to conserve angular momentum (spin) of electrons and nuclei. It is now detected for oxygen, silicon, sulfur, germanium, tin, mercury, magnesium, calcium, zinc, and uranium in a great variety of chemical and biochemical reactions including those of medical and ecological importance. Another mass-independent isotope effect was detected in 1983 as a deviation of isotopic distribution in reaction products from that which would be expected from the mass-dependent isotope effect. On the physical basis, it is in fact a mass-dependent effect, but it surprisingly results in isotope fractionation which is incompatible with that predicted by traditional mass-dependent effects. It is supposed to be a function of dynamic parameters of reaction and energy relaxation in excited states of products. The third, nuclear volume mass-independent isotope effect is detected in the high-resolution atomic and molecular spectra and in the extraction processes, but there are no unambiguous indications of its importance as an isotope fractionation factor in chemical reactions.

15. Independent Component Analysis of Textures

NASA Technical Reports Server (NTRS)

Manduchi, Roberto; Portilla, Javier

2000-01-01

A common method for texture representation is to use the marginal probability densities over the outputs of a set of multi-orientation, multi-scale filters as a description of the texture. We propose a technique, based on Independent Components Analysis, for choosing the set of filters that yield the most informative marginals, meaning that the product over the marginals most closely approximates the joint probability density function of the filter outputs. The algorithm is implemented using a steerable filter space. Experiments involving both texture classification and synthesis show that compared to Principal Components Analysis, ICA provides superior performance for modeling of natural and synthetic textures.

16. Subgroup finding via Bayesian additive regression trees.

PubMed

Sivaganesan, Siva; Müller, Peter; Huang, Bin

2017-03-09

We provide a Bayesian decision theoretic approach to finding subgroups that have elevated treatment effects. Our approach separates the modeling of the response variable from the task of subgroup finding and allows a flexible modeling of the response variable irrespective of potential subgroups of interest. We use Bayesian additive regression trees to model the response variable and use a utility function defined in terms of a candidate subgroup and the predicted response for that subgroup. Subgroups are identified by maximizing the expected utility where the expectation is taken with respect to the posterior predictive distribution of the response, and the maximization is carried out over an a priori specified set of candidate subgroups. Our approach allows subgroups based on both quantitative and categorical covariates. We illustrate the approach using simulated data set study and a real data set. Copyright © 2017 John Wiley & Sons, Ltd.

17. Application of independent component analysis in face images: a survey

NASA Astrophysics Data System (ADS)

Huang, Yuchi; Lu, Hanqing

2003-09-01

Face technologies which can be applied to access control and surveillance, are essential to intelligent vision-based human computer interaction. The research efforts in this field include face detecting, face recognition, face retrieval, etc. However, these tasks are challenging because of variability in view point, lighting, pose and expression of human faces. The ideal face representation should consider the variability so as to we can develop robust algorithms for our applications. Independent Component Analysis (ICA) as an unsupervised learning technique has been used to find such a representation and obtained good performances in some applications. In the first part of this paper, we depict the models of ICA and its extensions: Independent Subspace Analysis (ISA) and Topographic ICA (TICA).Then we summaraize the process in the applications of ICA and its extension in Face images. At last we propose a promising direction for future research.

18. A Hard Look at Independent Study

ERIC Educational Resources Information Center

Wilson, Whitelaw

1976-01-01

Sparked by James P. Beckford's article, "Administering the Independent Study Program" (Independent School Bulletin, February 1974, p.57), the author supplemented his comments by addressing two major aspects of independent study. The first is the notion that independent study is an educational vehicle or tool and the second is how it fits in with a…

19. Conflictual Independence, Adult Attachment Orientation, and Career Indecision among Asian American Students

ERIC Educational Resources Information Center

Keller, Chad J.; Brown, Chris

2014-01-01

Due to prior research suggesting that relational variables are related to the career development process, we sought to understand how maternal conflictual independence, paternal conflictual independence, attachment anxiety, and attachment avoidance influence the career decision status of Asian American undergraduate students (N = 113). The…

20. The Functional Independence of Mands and Tacts: Has It Been Demonstrated Empirically?

ERIC Educational Resources Information Center

Gamba, Jonas; Goyos, Celso; Petursdottir, Anna Ingeborg

2015-01-01

Recently, there has been a proliferation of research on the functional independence of two of Skinner's (1957) verbal operants, the mand, and the tact. This research has produced highly variable results. In this article, we provide a critical review of the literature on mand-tact independence, a literature that has implications for both theory and…

1. Secured Independent Tools in Peritoneoscopy

PubMed Central

Davila, Fausto; Dominguez, Guillermo; Manolas, Panagiotis

2010-01-01

Background and Objectives: Secured independent tools are being introduced to aid in peritoneoscopy. We present a simple technique for anchoring instruments, powered lights, and micro machines through the abdominal wall. Methods: We used a laparoscopic trainer, micro alligator clips with one or two 2-0 nylon tails and cables for engines and lights. The above instruments were introduced via a 12-mm or 15-mm port. Clips were placed for traction, retraction and exposure, lights for illumination, and motors for potential work. A laparoscopy port closure or suture passer was introduced percutaneously to grab and extract the tails or cables outside of the simulated abdominal cavity. The engines and lights were powered by a direct electric current (DC) plugged into exteriorized cables. Results: We used 2 to 3 clips for each, and engines performed well. Conclusion: This basic simulation adds independent instruments, lights, and engines. We replaced cannulas with threads or cables in an attempt to limit the number of ports. This technique further opens the door for innovations in wired machines in laparoscopy, single-port laparoscopy, or natural orifice surgery. PMID:20932379

2. ]Space Shuttle Independent Assessment Team

NASA Technical Reports Server (NTRS)

2000-01-01

The Shuttle program is one of the most complex engineering activities undertaken anywhere in the world at the present time. The Space Shuttle Independent Assessment Team (SIAT) was chartered in September 1999 by NASA to provide an independent review of the Space Shuttle sub-systems and maintenance practices. During the period from October through December 1999, the team led by Dr. McDonald and comprised of NASA, contractor, and DOD experts reviewed NASA practices, Space Shuffle anomalies, as well as civilian and military aerospace experience. In performing the review, much of a very positive nature was observed by the SIAT, not the least of which was the skill and dedication of the workforce. It is in the unfortunate nature of this type of review that the very positive elements are either not mentioned or dwelt upon. This very complex program has undergone a massive change in structure in the last few years with the transition to a slimmed down, contractor-run operation, the Shuttle Flight Operations Contract (SFOC). This has been accomplished with significant cost savings and without a major incident. This report has identified significant problems that must be addressed to maintain an effective program. These problems are described in each of the Issues, Findings or Observations summarized, and unless noted, appear to be systemic in nature and not confined to any one Shuttle sub-system or element. Specifics are given in the body of the report, along with recommendations to improve the present systems.

3. A package for the automated classification of periodic variable stars

NASA Astrophysics Data System (ADS)

Kim, Dae-Won; Bailer-Jones, Coryn A. L.

2016-03-01

We present a machine learning package for the classification of periodic variable stars. Our package is intended to be general: it can classify any single band optical light curve comprising at least a few tens of observations covering durations from weeks to years with arbitrary time sampling. We use light curves of periodic variable stars taken from OGLE and EROS-2 to train the model. To make our classifier relatively survey-independent, it is trained on 16 features extracted from the light curves (e.g., period, skewness, Fourier amplitude ratio). The model classifies light curves into one of seven superclasses - δ Scuti, RR Lyrae, Cepheid, Type II Cepheid, eclipsing binary, long-period variable, non-variable - as well as subclasses of these, such as ab, c, d, and e types for RR Lyraes. When trained to give only superclasses, our model achieves 0.98 for both recall and precision as measured on an independent validation dataset (on a scale of 0 to 1). When trained to give subclasses, it achieves 0.81 for both recall and precision. The majority of misclassifications of the subclass model is caused by confusion within a superclass rather than between superclasses. To assess classification performance of the subclass model, we applied it to the MACHO, LINEAR, and ASAS periodic variables, which gave recall/precision of 0.92/0.98, 0.89/0.96, and 0.84/0.88, respectively. We also applied the subclass model to Hipparcos periodic variable stars of many other variability types that do not exist in our training set, in order to examine how much those types degrade the classification performance of our target classes. In addition, we investigate how the performance varies with the number of data points and duration of observations. We find that recall and precision do not vary significantly if there are more than 80 data points and the duration is more than a few weeks. The classifier software of the subclass model is available (in Python) from the GitHub repository (http

4. Mid-space-independent deformable image registration.

PubMed

Aganj, Iman; Iglesias, Juan Eugenio; Reuter, Martin; Sabuncu, Mert Rory; Fischl, Bruce

2017-02-24

Aligning images in a mid-space is a common approach to ensuring that deformable image registration is symmetric - that it does not depend on the arbitrary ordering of the input images. The results are, however, generally dependent on the mathematical definition of the mid-space. In particular, the set of possible solutions is typically restricted by the constraints that are enforced on the transformations to prevent the mid-space from drifting too far from the native image spaces. The use of an implicit atlas has been proposed as an approach to mid-space image registration. In this work, we show that when the atlas is aligned to each image in the native image space, the data term of implicit-atlas-based deformable registration is inherently independent of the mid-space. In addition, we show that the regularization term can be reformulated independently of the mid-space as well. We derive a new symmetric cost function that only depends on the transformation morphing the images to each other, rather than to the atlas. This eliminates the need for anti-drift constraints, thereby expanding the space of allowable deformations. We provide an implementation scheme for the proposed framework, and validate it through diffeomorphic registration experiments on brain magnetic resonance images.

5. Independent and linked migrants: determinants of African American interstate migration.

PubMed

Lee, S W; Roseman, C C

1997-01-01

"Through kinship and other links to destinations, many African American interstate migrants in the United States join other people in destination households. These ¿linked' migrants contrast to ¿independent migrants' who move as individuals or intact groups and set up their own households at the destination. Using U.S. Census Public Use Micro Sample data, this paper first shows that, in the 1985-90 period, about 45 percent of all Black interstate migrants were independent, compared to 38 percent who were linked to housing at the destination and 17 percent who moved into group quarters. Second, a multinomial logit model, incorporating individual and state-level variables, is specified that contrasts the determinants of independent and linked migration.... It is concluded that the understanding of Black migration must take into account a variety of factors beyond traditional labor market conditions, including links to the destination and individual housing circumstances."

6. Measurement-device-independent quantum cryptography

SciTech Connect

Xu, Feihu; Curty, Marcos; Qi, Bing; Lo, Hoi-Kwong

2014-12-18

In theory, quantum key distribution (QKD) provides information-theoretic security based on the laws of physics. Owing to the imperfections of real-life implementations, however, there is a big gap between the theory and practice of QKD, which has been recently exploited by several quantum hacking activities. To fill this gap, a novel approach, called measurement-device-independent QKD (mdiQKD), has been proposed. In addition, it can remove all side-channels from the measurement unit, arguably the most vulnerable part in QKD systems, thus offering a clear avenue toward secure QKD realisations. In this study, we review the latest developments in the framework of mdiQKD, together with its assumptions, strengths, and weaknesses.

7. Measurement-device-independent quantum cryptography

DOE PAGES

Xu, Feihu; Curty, Marcos; Qi, Bing; ...

2014-12-18

In theory, quantum key distribution (QKD) provides information-theoretic security based on the laws of physics. Owing to the imperfections of real-life implementations, however, there is a big gap between the theory and practice of QKD, which has been recently exploited by several quantum hacking activities. To fill this gap, a novel approach, called measurement-device-independent QKD (mdiQKD), has been proposed. In addition, it can remove all side-channels from the measurement unit, arguably the most vulnerable part in QKD systems, thus offering a clear avenue toward secure QKD realisations. In this study, we review the latest developments in the framework of mdiQKD,more » together with its assumptions, strengths, and weaknesses.« less

8. Response variability of frontal eye field neurons modulates with sensory input and saccade preparation but not visual search salience

PubMed Central

Purcell, Braden A.; Heitz, Richard P.; Cohen, Jeremiah Y.

2012-01-01

Discharge rate modulation of frontal eye field (FEF) neurons has been identified with a representation of visual search salience (physical conspicuity and behavioral relevance) and saccade preparation. We tested whether salience or saccade preparation are evident in the trial-to-trial variability of discharge rate. We quantified response variability via the Fano factor in FEF neurons recorded in monkeys performing efficient and inefficient visual search tasks. Response variability declined following stimulus presentation in most neurons, but despite clear discharge rate modulation, variability did not change with target salience. Instead, we found that response variability was modulated by stimulus luminance and the number of items in the visual field independently of attentional demands. Response variability declined to a minimum before saccade initiation, and presaccadic response variability was directionally tuned. In addition, response variability was correlated with the response time of memory-guided saccades. These results indicate that the trial-by-trial response variability of FEF neurons reflects saccade preparation and the strength of sensory input, but not visual search salience or attentional allocation. PMID:22956785

9. Explained variance in the thermoregulatory responses to exercise: the independent roles of biophysical and fitness/fatness-related factors

PubMed Central

Cramer, Matthew N.

2015-01-01

10. Explained variance in the thermoregulatory responses to exercise: the independent roles of biophysical and fitness/fatness-related factors.

PubMed

Cramer, Matthew N; Jay, Ollie

2015-11-01

11. Transferability of regional permafrost disturbance susceptibility modelling using generalized linear and generalized additive models

NASA Astrophysics Data System (ADS)

Rudy, Ashley C. A.; Lamoureux, Scott F.; Treitz, Paul; van Ewijk, Karin Y.

2016-07-01

To effectively assess and mitigate risk of permafrost disturbance, disturbance-prone areas can be predicted through the application of susceptibility models. In this study we developed regional susceptibility models for permafrost disturbances using a field disturbance inventory to test the transferability of the model to a broader region in the Canadian High Arctic. Resulting maps of susceptibility were then used to explore the effect of terrain variables on the occurrence of disturbances within this region. To account for a large range of landscape characteristics, the model was calibrated using two locations: Sabine Peninsula, Melville Island, NU, and Fosheim Peninsula, Ellesmere Island, NU. Spatial patterns of disturbance were predicted with a generalized linear model (GLM) and generalized additive model (GAM), each calibrated using disturbed and randomized undisturbed locations from both locations and GIS-derived terrain predictor variables including slope, potential incoming solar radiation, wetness index, topographic position index, elevation, and distance to water. Each model was validated for the Sabine and Fosheim Peninsulas using independent data sets while the transferability of the model to an independent site was assessed at Cape Bounty, Melville Island, NU. The regional GLM and GAM validated well for both calibration sites (Sabine and Fosheim) with the area under the receiver operating curves (AUROC) > 0.79. Both models were applied directly to Cape Bounty without calibration and validated equally with AUROC's of 0.76; however, each model predicted disturbed and undisturbed samples differently. Additionally, the sensitivity of the transferred model was assessed using data sets with different sample sizes. Results indicated that models based on larger sample sizes transferred more consistently and captured the variability within the terrain attributes in the respective study areas. Terrain attributes associated with the initiation of disturbances were

12. Array Independent Component Analysis with Application to Remote Sensing

NASA Astrophysics Data System (ADS)

Kukuyeva, Irina A.

2012-11-01

There are three ways to learn about an object: from samples taken directly from the site, from simulation studies based on its known scientific properties, or from remote sensing images. All three are carried out to study Earth and Mars. Our goal, however, is to learn about the second largest storm on Jupiter, called the White Oval, whose characteristics are unknown to this day. As Jupiter is a gas giant and hundreds of millions of miles away from Earth, we can only make inferences about the planet from retrieval algorithms and remotely sensed images. Our focus is to find latent variables from the remotely sensed data that best explain its underlying atmospheric structure. Principal Component Analysis (PCA) is currently the most commonly employed technique to do so. For a data set with more than two modes, this approach fails to account for all of the variable interactions, especially if the distribution of the variables is not multivariate normal; an assumption that is rarely true of multispectral images. The thesis presents an overview of PCA along with the most commonly employed decompositions in other fields: Independent Component Analysis, Tucker-3 and CANDECOMP/PARAFAC and discusses their limitations in finding unobserved, independent structures in a data cube. We motivate the need for a novel dimension reduction technique that generalizes existing decompositions to find latent, statistically independent variables for one side of a multimodal (number of modes greater than two) data set while accounting for the variable interactions with its other modes. Our method is called Array Independent Component Analysis (AICA). As the main question of any decomposition is how to select a small number of latent variables that best capture the structure in the data, we extend the heuristic developed by Ceulemans and Kiers in [10] to aid in model selection for the AICA framework. The effectiveness of each dimension reduction technique is determined by the degree of

13. Variable gravity research facility

NASA Technical Reports Server (NTRS)

1987-01-01

Eight fourth-year engineering design students formed two teams to study methods of varying the perceived gravity level in a variable gravity research facility. A tether system and an arm system were the chosen topics. Both teams have produced and built scale models of their design. In addition, a three-credit Special Topics Course (Aviation 370) was formed, as the project offers an excellent opportunity to build a multi-disciplinary program around the initial conceptualization process. Fifty students were registered in the Special Topics course. Each week during a three hour class, a guest lecturer covered one or more of the many areas associated with the concept of a variable-gravity facility. The students formed small groups organized on a multi-disciplinary basis (there were twelve separate disciplines represented by one or more students) where they discussed among themselves the various issues involved. These groups also met outside class for three or more hours each week. During class each group presented oral reports on their findings during a one-hour general question and answer period.

14. Identification of cognitive and non-cognitive predictive variables related to attrition in baccalaureate nursing education programs in Mississippi

NASA Astrophysics Data System (ADS)

Hayes, Catherine

2005-07-01

This study sought to identify a variable or variables predictive of attrition among baccalaureate nursing students. The study was quantitative in design and multivariate correlational statistics and discriminant statistical analysis were used to identify a model for prediction of attrition. The analysis then weighted variables according to their predictive value to determine the most parsimonious model with the greatest predictive value. Three public university nursing education programs in Mississippi offering a Bachelors Degree in Nursing were selected for the study. The population consisted of students accepted and enrolled in these three programs for the years 2001 and 2002 and graduating in the years 2003 and 2004 (N = 195). The categorical dependent variable was attrition (includes academic failure or withdrawal) from the program of nursing education. The ten independent variables selected for the study and considered to have possible predictive value were: Grade Point Average for Pre-requisite Course Work; ACT Composite Score, ACT Reading Subscore, and ACT Mathematics Subscore; Letter Grades in the Courses: Anatomy & Physiology and Lab I, Algebra I, English I (101), Chemistry & Lab I, and Microbiology & Lab I; and Number of Institutions Attended (Universities, Colleges, Junior Colleges or Community Colleges). Descriptive analysis was performed and the means of each of the ten independent variables was compared for students who attrited and those who were retained in the population. The discriminant statistical analysis performed created a matrix using the ten variable model that was able to correctly predicted attrition in the study's population in 77.6% of the cases. Variables were then combined and recombined to produce the most efficient and parsimonious model for prediction. A six variable model resulted which weighted each variable according to predictive value: GPA for Prerequisite Coursework, ACT Composite, English I, Chemistry & Lab I, Microbiology

15. Learning to Spell: Raising Standards in Spelling and Independent Writing

ERIC Educational Resources Information Center

McMurray, Sharon

2006-01-01

This paper considers evidence from an intervention designed to raise standards in spelling and independent writing. "The Complete Spelling Programme" (McMurray and Fleming, 1998) is designed to ensure that all processes involved in learning to spell are activated and that the interaction between them is facilitated. In addition, a number…

16. Current Climate Variability & Change

NASA Astrophysics Data System (ADS)

Diem, J.; Criswell, B.; Elliott, W. C.

2013-12-01

Current Climate Variability & Change is the ninth among a suite of ten interconnected, sequential labs that address all 39 climate-literacy concepts in the U.S. Global Change Research Program's Climate Literacy: The Essential Principles of Climate Sciences. The labs are as follows: Solar Radiation & Seasons, Stratospheric Ozone, The Troposphere, The Carbon Cycle, Global Surface Temperature, Glacial-Interglacial Cycles, Temperature Changes over the Past Millennium, Climates & Ecosystems, Current Climate Variability & Change, and Future Climate Change. All are inquiry-based, on-line products designed in a way that enables students to construct their own knowledge of a topic. Questions representative of various levels of Webb's depth of knowledge are embedded in each lab. In addition to the embedded questions, each lab has three or four essential questions related to the driving questions for the lab suite. These essential questions are presented as statements at the beginning of the material to represent the lab objectives, and then are asked at the end as questions to function as a summative assessment. For example, the Current Climate Variability & Change is built around these essential questions: (1) What has happened to the global temperature at the Earth's surface, in the middle troposphere, and in the lower stratosphere over the past several decades?; (2) What is the most likely cause of the changes in global temperature over the past several decades and what evidence is there that this is the cause?; and (3) What have been some of the clearly defined effects of the change in global temperature on the atmosphere and other spheres of the Earth system? An introductory Prezi allows the instructor to assess students' prior knowledge in relation to these questions, while also providing 'hooks' to pique their interest related to the topic. The lab begins by presenting examples of and key differences between climate variability (e.g., Mt. Pinatubo eruption) and

17. Variable conductance heat pipe technology

NASA Technical Reports Server (NTRS)

Marcus, B. D.; Edwards, D. K.; Anderson, W. T.

1973-01-01

Research and development programs in variable conductance heat pipe technology were conducted. The treatment has been comprehensive, involving theoretical and/or experimental studies in hydrostatics, hydrodynamics, heat transfer into and out of the pipe, fluid selection, and materials compatibility, in addition to the principal subject of variable conductance control techniques. Efforts were not limited to analytical work and laboratory experimentation, but extended to the development, fabrication and test of spacecraft hardware, culminating in the successful flight of the Ames Heat Pipe Experiment on the OAO-C spacecraft.

18. Independent predictors of delay in emergence from general anesthesia.

PubMed

Maeda, Shigeru; Tomoyasu, Yumiko; Higuchi, Hitoshi; Ishii-Maruhama, Minako; Egusa, Masahiko; Miyawaki, Takuya

2015-01-01

Some patients with intellectual disabilities spend longer than others in emergence from ambulatory general anesthesia for dental treatment. Although antiepileptic drugs and anesthetics might be involved, an independent predictor for delay of the emergence remains unclear. Thus, a purpose of this study is to identify independent factors affecting the delay of emergence from general anesthesia. This was a retrospective cohort study in dental patients with intellectual disabilities. Patients in need of sedative premedication were removed from participants. The outcome was time until emergence from general anesthesia. Stepwise multivariate regression analysis was used to extract independent factors affecting the outcome. Antiepileptic drugs and anesthetic parameters were included as predictor variables. The study included 102 cases. Clobazam, clonazepam, and phenobarbital were shown to be independent determinants of emergence time. Parameters relating to anesthetics, patients' backgrounds, and dental treatment were not independent factors. Delay in emergence time in ambulatory general anesthesia is likely to be related to the antiepileptic drugs of benzodiazepine or barbiturates in patients with intellectual disability.

19. Anaerobic sludge digestion with a biocatalytic additive

SciTech Connect

Ghosh, S.; Henry, M.P.; Fedde, P.A.

1982-01-01

20. Fluctuation theorems and entropy production with odd-parity variables

NASA Astrophysics Data System (ADS)

Park, Hyunggyu; Lee, Hyun Keun; Kwon, Chulan

2013-03-01

We show that the total entropy production in stochastic processes with odd-parity variables (under time reversal) is separated into three parts, only two of which satisfy the integral fluctuation theorems in general. One is the usual excess contribution, which can appear only transiently and is called non-adiabatic. Another one is attributed solely to the breakage of detailed balance. The last part not satisfying the fluctuation theorem comes from the steady-state distribution asymmetry for odd-parity variables, which is activated in a non-transient manner. The latter two parts combine together as the house-keeping (adiabatic) contribution, whose positivity is not guaranteed except when the excess contribution completely vanishes. Our finding reveals that the equilibrium requires the steady-state distribution symmetry for odd-parity variables independently, in addition to the usual detailed balance. This work was supported by Mid-career Researcher Program through NRF grant (No. 2010-0026627) funded by the MEST.

1. Instrument independent diffuse reflectance spectroscopy.

PubMed

Yu, Bing; Fu, Henry L; Ramanujam, Nirmala

2011-01-01

Diffuse reflectance spectroscopy with a fiber optic probe is a powerful tool for quantitative tissue characterization and disease diagnosis. Significant systematic errors can arise in the measured reflectance spectra and thus in the derived tissue physiological and morphological parameters due to real-time instrument fluctuations. We demonstrate a novel fiber optic probe with real-time, self-calibration capability that can be used for UV-visible diffuse reflectance spectroscopy in biological tissue in clinical settings. The probe is tested in a number of synthetic liquid phantoms over a wide range of tissue optical properties for significant variations in source intensity fluctuations caused by instrument warm up and day-to-day drift. While the accuracy for extraction of absorber concentrations is comparable to that achieved with the traditional calibration (with a reflectance standard), the accuracy for extraction of reduced scattering coefficients is significantly improved with the self-calibration probe compared to traditional calibration. This technology could be used to achieve instrument-independent diffuse reflectance spectroscopy in vivo and obviate the need for instrument warm up and post∕premeasurement calibration, thus saving up to an hour of precious clinical time.

2. Preprototype independent air revitalization subsystem

NASA Technical Reports Server (NTRS)

Schubert, F. H.; Hallick, T. M.; Woods, R. R.

1982-01-01

The performance and maturity of a preprototype, three-person capacity, automatically controlled and monitored, self-contained independent air revitalization subsystem were evaluated. The subsystem maintains the cabin partial pressure of oxygen at 22 kPa (3.2 psia) and that of carbon dioxide at 400 Pa (3 mm Hg) over a wide range of cabin air relative humidity conditions. Consumption of water vapor by the water vapor electrolysis module also provides partial humidity control of the cabin environment. During operation, the average carbon dioxide removal efficiency at baseline conditions remained constant throughout the test at 84%. The average electrochemical depolarized concentrator cell voltage at the end of the parametric/endurance test was 0.41 V, representing a very slowly decreasing average cell voltage. The average water vapor electrolysis cell voltage increased only at a rate of 20 mu/h from the initial level of 1.67 V to the final level of 1.69 V at conclusion of the testing.

3. Sampling and repeatability in the evaluation of hepatitis C virus genetic variability.

PubMed

Torres-Puente, Manuela; Bracho, M Alma; Jiménez, Nuria; García-Robles, Inmaculada; Moya, Andrés; González-Candelas, Fernando

2003-09-01

Among the experimental techniques available to study the genetic variability of RNA virus populations, the most informative involve reverse transcription (RT), amplification, cloning and sequencing. The effects of several aspects of these techniques on the estimation of genetic variability in a virus population were analysed. Hepatitis C virus populations from four patients were examined. For each patient, ten series of data derived from independent PCR amplifications of a single RT reaction were obtained. The sample size of each data set was 10 sequences (in nine series) and 100 sequences (in one series). An additional data set derived from an independent RT reaction (about 10 sequences) performed on RNA extracted from the same serum sample was also analysed. The availability of data sets of different sample sizes allowed the effect of sample size on the amount and nature of the genetic variability recovered to be examined. The repeatability of the data obtained in different amplification experiments as well as from different RT reactions was also determined, together with the best strategy to obtain a given number of sequences by comparing the set of 100 sequences obtained from a single amplification with those obtained by pooling the nine sets of 10 sequences. In all cases, these results confirm the high repeatability of the conclusions and parameters derived from the sets of 10 sequences. These results validate the use of relatively small sample sets for the evaluation of genetic variability and for the estimation of phylogenetic relationships of RNA viruses in population and epidemiological studies.

4. Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study

PubMed Central

Wackers, Frans JTh; Inzucchi, Silvio E; Jose, Powell; Weiss, Curtis; Davey, Janice A; Heller, Gary V; Iskandrian, Ami E; Young, Lawrence H

2015-01-01

Objective: The primary aim of this secondary analysis was to determine whether cardiac autonomic neuropathy independently predicted adverse cardiac outcomes in asymptomatic individuals with type 2 diabetes. Additional aims include the determination of the correlation of standard autonomic testing measures and power spectral analysis of heart rate variability, and the association of diabetes-related and cardiac risk factors with cardiac autonomic neuropathy measures. Methods: Cardiac autonomic neuropathy was assessed at the study entry into the Detection of Ischemia in Asymptomatic Diabetics study, using autonomic heart rate and blood pressure testing, and power spectral analysis of heart rate variability. All participants were prospectively followed for the composite clinical outcome of cardiac death, acute coronary syndromes, heart failure, or coronary revascularization. Results: Over 5 years of follow-up, 94 of 1119 (8.4%) subjects developed symptomatic cardiac disease. In unadjusted bivariate analyses, abnormalities in several cardiac autonomic neuropathy tests, including lower Valsalva and Standing Heart Rate Ratios, higher resting Heart Rate, greater systolic blood pressure decrease on standing, and lower low-frequency power, were predictive of symptomatic disease. Independent predictors of poor cardiac outcome were a lower Valsalva Heart Rate Ratio, non-Black ethnicity, longer diabetes duration, higher glycated hemoglobin (HbA1c), insulin use, reported numbness in the extremities, higher pulse pressure, family history of coronary artery disease, and higher waist-to-hip ratio. Clinical factors independently associated with a lower Valsalva Heart Rate Ratio were insulin use, clinical proteinuria, higher pulse pressure, use of angiotensin-converting enzyme inhibitor and non-Black ethnicity. Conclusion: Cardiac autonomic neuropathy predicted adverse cardiac outcomes in asymptomatic type 2 diabetes without known cardiac disease. Clinical variables may help to

5. Variable Selection in Semiparametric Regression Modeling.

PubMed

Li, Runze; Liang, Hua

2008-01-01

In this paper, we are concerned with how to select significant variables in semiparametric modeling. Variable selection for semiparametric regression models consists of two components: model selection for nonparametric components and select significant variables for parametric portion. Thus, it is much more challenging than that for parametric models such as linear models and generalized linear models because traditional variable selection procedures including stepwise regression and the best subset selection require model selection to nonparametric components for each submodel. This leads to very heavy computational burden. In this paper, we propose a class of variable selection procedures for semiparametric regression models using nonconcave penalized likelihood. The newly proposed procedures are distinguished from the traditional ones in that they delete insignificant variables and estimate the coefficients of significant variables simultaneously. This allows us to establish the sampling properties of the resulting estimate. We first establish the rate of convergence of the resulting estimate. With proper choices of penalty functions and regularization parameters, we then establish the asymptotic normality of the resulting estimate, and further demonstrate that the proposed procedures perform as well as an oracle procedure. Semiparametric generalized likelihood ratio test is proposed to select significant variables in the nonparametric component. We investigate the asymptotic behavior of the proposed test and demonstrate its limiting null distribution follows a chi-squared distribution, which is independent of the nuisance parameters. Extensive Monte Carlo simulation studies are conducted to examine the finite sample performance of the proposed variable selection procedures.

6. Learning Dilemmas in Undergraduate Student Independent Essays

ERIC Educational Resources Information Center

Wendt, Maria; Åse, Cecilia

2015-01-01

Essay-writing is generally viewed as the primary learning activity to foster independence and analytical thinking. In this article, we show that independent research projects do not necessarily lead to critical thinking. University-level education on conducting independent projects can, in several respects, counteract enhanced analytical skills.…

7. 47 CFR 64.904 - Independent audits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 3 2012-10-01 2012-10-01 false Independent audits. 64.904 Section 64.904... RULES RELATING TO COMMON CARRIERS Allocation of Costs § 64.904 Independent audits. (a) Each carrier... independent auditor every two years, covering the prior two year period, or have a financial audit...

8. 47 CFR 64.904 - Independent audits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 3 2013-10-01 2013-10-01 false Independent audits. 64.904 Section 64.904... RULES RELATING TO COMMON CARRIERS Allocation of Costs § 64.904 Independent audits. (a) Each carrier... independent auditor every two years, covering the prior two year period, or have a financial audit...

9. Independence, Individualism & Connection among Share Householders

ERIC Educational Resources Information Center

Natalier, Kristin

2007-01-01

How do young people who are financially dependent on their parents but living in share households conceive of the concept of independence? The meanings of independence are discussed in relation to a qualitative study of young people who described themselves as independent although they accepted money on a regular basis from their parents. Their…

10. 47 CFR 64.904 - Independent audits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Independent audits. 64.904 Section 64.904... RULES RELATING TO COMMON CARRIERS Allocation of Costs § 64.904 Independent audits. (a) Each carrier... independent auditor every two years, covering the prior two year period, or have a financial audit...

11. 45 CFR 1309.44 - Independent analysis.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Independent analysis. 1309.44 Section 1309.44... § 1309.44 Independent analysis. (a) The responsible HHS official may direct the grantee applying for funds to acquire or make major renovations to a facility to obtain an independent analysis of the...

12. 45 CFR 1309.44 - Independent analysis.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Independent analysis. 1309.44 Section 1309.44... § 1309.44 Independent analysis. (a) The responsible HHS official may direct the grantee applying for funds to acquire or make major renovations to a facility to obtain an independent analysis of the...

13. 45 CFR 1309.44 - Independent analysis.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Independent analysis. 1309.44 Section 1309.44... § 1309.44 Independent analysis. (a) The responsible HHS official may direct the grantee applying for funds to acquire or make major renovations to a facility to obtain an independent analysis of the...

14. 45 CFR 1309.44 - Independent analysis.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Independent analysis. 1309.44 Section 1309.44... § 1309.44 Independent analysis. (a) The responsible HHS official may direct the grantee applying for funds to acquire or make major renovations to a facility to obtain an independent analysis of the...

15. 45 CFR 1309.44 - Independent analysis.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Independent analysis. 1309.44 Section 1309.44... § 1309.44 Independent analysis. (a) The responsible HHS official may direct the grantee applying for funds to acquire or make major renovations to a facility to obtain an independent analysis of the...

16. 46 CFR 62.30-5 - Independence.

Code of Federal Regulations, 2010 CFR

2010-10-01

... instrumentation systems for any vital system must be independent of each other. (2) Independent sensors are not required except that sensors for primary speed, pitch, or direction of rotation control in closed loop..., or instrumentation sensors. (3) The safety trip control of § 62.35-5(b)(2) must be independent...

17. 11 CFR 100.113 - Independent expenditures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Independent expenditures. 100.113 Section 100...) Definition of Expenditure (2 U.S.C. 431(9)) § 100.113 Independent expenditures. An independent expenditure that meets the requirements of 11 CFR 104.4 or part 109 is an expenditure, and such...

18. The SU(2) action-angle variables

NASA Technical Reports Server (NTRS)

Ellinas, Demosthenes

1993-01-01

Operator angle-action variables are studied in the frame of the SU(2) algebra, and their eigenstates and coherent states are discussed. The quantum mechanical addition of action-angle variables is shown to lead to a noncommutative Hopf algebra. The group contraction is used to make the connection with the harmonic oscillator.

19. Environmental Variables as Predictors of Academic Performance.

ERIC Educational Resources Information Center

Henderson, Ronald W.

This project used six environmental variables identified by Dave (1963) and Wolf (1964) and three additional variables (identification with models, range of social interaction, and perception of practical value of education) to predict academic achievement in six-year-old Mexican-American children from an economically depressed area. The children…

20. Large Independent Primary Care Medical Groups

PubMed Central

Casalino, Lawrence P.; Chen, Melinda A.; Staub, C. Todd; Press, Matthew J.; Mendelsohn, Jayme L.; Lynch, John T.; Miranda, Yesenia

2016-01-01

PURPOSE In the turbulent US health care environment, many primary care physicians seek hospital employment. Large physician-owned primary care groups are an alternative, but few physicians or policy makers realize that such groups exist. We wanted to describe these groups, their advantages, and their challenges. METHODS We identified 21 groups and studied 5 that varied in size and location. We conducted interviews with group leaders, surveyed randomly selected group physicians, and interviewed external observers—leaders of a health plan, hospital, and specialty medical group that shared patients with the group. We triangulated responses from group leaders, group physicians, and external observers to identify key themes. RESULTS The groups’ physicians work in small practices, with the group providing economies of scale necessary to develop laboratory and imaging services, health information technology, and quality improvement infrastructure. The groups differ in their size and the extent to which they engage in value-based contracting, though all are moving to increase the amount of financial risk they take for their quality and cost performance. Unlike hospital-employed and multispecialty groups, independent primary care groups can aim to reduce health care costs without conflicting incentives to fill hospital beds and keep specialist incomes high. Each group was positively regarded by external observers. The groups are under pressure, however, to sell to organizations that can provide capital for additional infrastructure to engage in value-based contracting, as well as provide substantial income to physicians from the sale. CONCLUSIONS Large, independent primary care groups have the potential to make primary care attractive to physicians and to improve patient care by combining human scale advantages of physician autonomy and the small practice setting with resources that are important to succeed in value-based contracting. PMID:26755779

1. Calibration Variable Selection and Natural Zero Determination for Semispan and Canard Balances

NASA Technical Reports Server (NTRS)

Ulbrich, Norbert M.

2013-01-01

Independent calibration variables for the characterization of semispan and canard wind tunnel balances are discussed. It is shown that the variable selection for a semispan balance is determined by the location of the resultant normal and axial forces that act on the balance. These two forces are the first and second calibration variable. The pitching moment becomes the third calibration variable after the normal and axial forces are shifted to the pitch axis of the balance. Two geometric distances, i.e., the rolling and yawing moment arms, are the fourth and fifth calibration variable. They are traditionally substituted by corresponding moments to simplify the use of calibration data during a wind tunnel test. A canard balance is related to a semispan balance. It also only measures loads on one half of a lifting surface. However, the axial force and yawing moment are of no interest to users of a canard balance. Therefore, its calibration variable set is reduced to the normal force, pitching moment, and rolling moment. The combined load diagrams of the rolling and yawing moment for a semispan balance are discussed. They may be used to illustrate connections between the wind tunnel model geometry, the test section size, and the calibration load schedule. Then, methods are reviewed that may be used to obtain the natural zeros of a semispan or canard balance. In addition, characteristics of three semispan balance calibration rigs are discussed. Finally, basic requirements for a full characterization of a semispan balance are reviewed.

2. Progress with variable cycle engines

NASA Technical Reports Server (NTRS)

Westmoreland, J. S.

1980-01-01

The evaluation of components of an advanced propulsion system for a future supersonic cruise vehicle is discussed. These components, a high performance duct burner for thrust augmentation and a low jet noise coannular exhaust nozzle, are part of the variable stream control engine. An experimental test program involving both isolated component and complete engine tests was conducted for the high performance, low emissions duct burner with excellent results. Nozzle model tests were completed which substantiate the inherent jet noise benefit associated with the unique velocity profile possible of a coannular exhaust nozzle system on a variable stream control engine. Additional nozzle model performance tests have established high thrust efficiency levels at takeoff and supersonic cruise for this nozzle system. Large scale testing of these two critical components is conducted using an F100 engine as the testbed for simulating the variable stream control engine.

3. Model independent MRE data analysis.

PubMed

Yoshikawa, Kogo; Nakamura, Gen

2013-01-01

For the diagnosing modality called MRE (magnetic resonance elastography), the displacement vector of a wave propagating in a human tissue can be measured. The average of the local wavelength from this measured data could be an index for the diagnosing, because the local wave length becomes larger when the tissue is stiffer. By assuming that the local form of the wave is given approximately as multiple complex plane waves, we identify the real part of the complex linear phase of the strongest plane wave of this multiple complex plane waves, by first applying the FBI transform (Fourier-Bros-Iagolnitzer transform) with an appropriate size of Gaussian window and then taking the maximum of the modulus of the transform with respect to the Fourier variable. The real part of the linear phase is nothing but the real inner product of the wave vector and the position vector. Similarly the imaginary part of the linear phase describes the attenuation of the wave and it is given as a real inner product of a real vector and the position vector. This vector can also be recovered by our method. We also apply these methods to design some denoising and filtering for noisy MRE data.

4. Orientation-independent measures of ground motion

USGS Publications Warehouse

Boore, D.M.; Watson-Lamprey, Jennie; Abrahamson, N.A.

2006-01-01

The geometric mean of the response spectra for two orthogonal horizontal components of motion, commonly used as the response variable in predictions of strong ground motion, depends on the orientation of the sensors as installed in the field. This means that the measure of ground-motion intensity could differ for the same actual ground motion. This dependence on sensor orientation is most pronounced for strongly correlated motion (the extreme example being linearly polarized motion), such as often occurs at periods of 1 sec or longer. We propose two new measures of the geometric mean, GMRotDpp, and GMRotIpp, that are independent of the sensor orientations. Both are based on a set of geometric means computed from the as-recorded orthogonal horizontal motions rotated through all possible non-redundant rotation angles. GMRotDpp is determined as the ppth percentile of the set of geometric means for a given oscillator period. For example, GMRotDOO, GMRotD50, and GMRotD100 correspond to the minimum, median, and maximum values, respectively. The rotations that lead to GMRotDpp depend on period, whereas a single-period-independent rotation is used for GMRotIpp, the angle being chosen to minimize the spread of the rotation-dependent geometric mean (normalized by GMRotDpp) over the usable range of oscillator periods. GMRotI50 is the ground-motion intensity measure being used in the development of new ground-motion prediction equations by the Pacific Earthquake Engineering Center Next Generation Attenuation project. Comparisons with as-recorded geometric means for a large dataset show that the new measures are systematically larger than the geometric-mean response spectra using the as-recorded values of ground acceleration, but only by a small amount (less than 3%). The theoretical advantage of the new measures is that they remove sensor orientation as a contributor to aleatory uncertainty. Whether the reduction is of practical significance awaits detailed studies of large

5. The additive and interactive effects of parenting and temperament in predicting adjustment problems of children of divorce.

PubMed

Lengua, L J; Wolchik, S A; Sandler, I N; West, S G

2000-06-01

Investigated the interaction between parenting and temperament in predicting adjustment problems in children of divorce. The study utilized a sample of 231 mothers and children, 9 to 12 years old, who had experienced divorce within the previous 2 years. Both mothers' and children's reports on parenting, temperament, and adjustment variables were obtained and combined to create cross-reporter measures of the variables. Parenting and temperament were directly and independently related to outcomes consistent with an additive model of their effects. Significant interactions indicated that parental rejection was more strongly related to adjustment problems for children low in positive emotionality, and inconsistent discipline was more strongly related to adjustment problems for children high in impulsivity. These findings suggest that children who are high in impulsivity may be at greater risk for developing problems, whereas positive emotionality may operate as a protective factor, decreasing the risk of adjustment problems in response to negative parenting.

6. Multiple brain networks underpinning word learning from fluent speech revealed by independent component analysis.

PubMed

López-Barroso, Diana; Ripollés, Pablo; Marco-Pallarés, Josep; Mohammadi, Bahram; Münte, Thomas F; Bachoud-Lévi, Anne-Catherine; Rodriguez-Fornells, Antoni; de Diego-Balaguer, Ruth

2015-04-15

Although neuroimaging studies using standard subtraction-based analysis from functional magnetic resonance imaging (fMRI) have suggested that frontal and temporal regions are involved in word learning from fluent speech, the possible contribution of different brain networks during this type of learning is still largely unknown. Indeed, univariate fMRI analyses cannot identify the full extent of distributed networks that are engaged by a complex task such as word learning. Here we used Independent Component Analysis (ICA) to characterize the different brain networks subserving word learning from an artificial language speech stream. Results were replicated in a second cohort of participants with a different linguistic background. Four spatially independent networks were associated with the task in both cohorts: (i) a dorsal Auditory-Premotor network; (ii) a dorsal Sensory-Motor network; (iii) a dorsal Fronto-Parietal network; and (iv) a ventral Fronto-Temporal network. The level of engagement of these networks varied through the learning period with only the dorsal Auditory-Premotor network being engaged across all blocks. In addition, the connectivity strength of this network in the second block of the learning phase correlated with the individual variability in word learning performance. These findings suggest that: (i) word learning relies on segregated connectivity patterns involving dorsal and ventral networks; and (ii) specifically, the dorsal auditory-premotor network connectivity strength is directly correlated with word learning performance.

7. Variable Valve Actuation

SciTech Connect

Jeffrey Gutterman; A. J. Lasley

2008-08-31

Many approaches exist to enable advanced mode, low temperature combustion systems for diesel engines - such as premixed charge compression ignition (PCCI), Homogeneous Charge Compression Ignition (HCCI) or other HCCI-like combustion modes. The fuel properties and the quantity, distribution and temperature profile of air, fuel and residual fraction in the cylinder can have a marked effect on the heat release rate and combustion phasing. Figure 1 shows that a systems approach is required for HCCI-like combustion. While the exact requirements remain unclear (and will vary depending on fuel, engine size and application), some form of substantially variable valve actuation is a likely element in such a system. Variable valve actuation, for both intake and exhaust valve events, is a potent tool for controlling the parameters that are critical to HCCI-like combustion and expanding its operational range. Additionally, VVA can be used to optimize the combustion process as well as exhaust temperatures and impact the after treatment system requirements and its associated cost. Delphi Corporation has major manufacturing and product development and applied R&D expertise in the valve train area. Historical R&D experience includes the development of fully variable electro-hydraulic valve train on research engines as well as several generations of mechanical VVA for gasoline systems. This experience has enabled us to evaluate various implementations and determine the strengths and weaknesses of each. While a fully variable electro-hydraulic valve train system might be the 'ideal' solution technically for maximum flexibility in the timing and control of the valve events, its complexity, associated costs, and high power consumption make its implementation on low cost high volume applications unlikely. Conversely, a simple mechanical system might be a low cost solution but not deliver the flexibility required for HCCI operation. After modeling more than 200 variations of the

8. Independent Orbiter Assessment (IOA): Assessment of the pyrotechnics subsystem

NASA Technical Reports Server (NTRS)

Robinson, W. M.

1988-01-01

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA effort first completed an analysis of the Pyrotechnics (PYRO) hardware, generating draft failure modes and potential critical items. To preserve independence, this analysis was accomplished without reliance upon the results contained within the NASA FMEA/CIL documentation. The IOA results were then compared to the NASA FMEA/CIL baseline with proposed Post 51-L updates included. A resolution of each discrepancy from the comparison is provided through additional analysis as required. This report documents the results of that comparison for the Orbiter Pyrotechnics hardware.

9. Independent rate and temporal coding in hippocampal pyramidal cells

PubMed Central

Huxter, John; Burgess, Neil; O’Keefe, John

2009-01-01

Hippocampal pyramidal cells use temporal 1 as well as rate coding 2 to signal spatial aspects of the animal’s environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal EEG theta rhythm (Figure 1​; 1). These two codes could each represent a different variable 3,4. However, this requires that rate and phase can vary independently, in contrast to recent suggestions 5,6 that they are tightly coupled: both reflecting the amplitude of the cell’s input. Here we show that the time of firing and firing rate are dissociable and can represent two independent variables, viz, the animal’s location within the place field and its speed of movement through the field, respectively. Independent encoding of location together with actions and stimuli occurring there may help to explain the dual roles of the hippocampus in spatial and episodic memory 7 8 or a more general role in relational/declarative memory9,10. PMID:14574410

10. Children, Additive Change, and Calculus.

ERIC Educational Resources Information Center

Nemirovsky, Ricardo; And Others

Students can learn to solve problems of qualitative integration and differentiation independently of their study of formal calculus or algebra. This exploratory study investigated the basic intuitions that elementary school children construct in their daily experience with physical and symbolic change. Elementary school children (n=18) were…

11. Effect of two natural light regimes and nutrient addition on the forest herb Begonia decandra (Begoniaceae).

PubMed

Cordero, R A

2000-01-01

The effect of two natural light-growing conditions (understory versus light gaps) and the interaction with nutrient availability (through fertilization) were studied in the understory herb Begonia decandra, in the Luquillo Experimental Forest in Puerto Rico. Sixteen potted plants obtained from cuttings were randomly chosen and distributed in each of eighth forest environments (four light gaps and four understories), for a total of 128 plants. Fertilizer was applied to half of the plants in each site. After seven months in the two given microenvironments, increased light and fertilization resulted in greater growth and some changes in the biomass allocation patterns. All measured variables responded similarly to reported changes for tree seedlings and saplings from other tropical and subtropical regions. Total growth parameters (height, biomass and leaf area) were very sensitive to increases in the main resource (light). The addition of nutrients was less important in producing changes in the allocation variables (root to shoot ratio, leaf area ratio, and specific leaf mass) under conditions of high light availability. Changes due to nutrient levels were relatively greater on plants grown under under-story conditions. Also, small light differences among sites can cause significant changes in the variables related to total growth. Lastly, plant mortality in the nutrient treatments was found to be independent of mortality in two forest light environments. Some hypotheses about resource acquisition and plant growth are not supported by this data.

12. “Skill of Generalized Additive Model to Detect PM2.5 Health ...

EPA Pesticide Factsheets

Summary. Measures of health outcomes are collinear with meteorology and air quality, making analysis of connections between human health and air quality difficult. The purpose of this analysis was to determine time scales and periods shared by the variables of interest (and by implication scales and periods that are not shared). Hospital admissions, meteorology (temperature and relative humidity), and air quality (PM2.5 and daily maximum ozone) for New York City during the period 2000-2006 were decomposed into temporal scales ranging from 2 days to greater than two years using a complex wavelet transform. Health effects were modeled as functions of the wavelet components of meteorology and air quality using the generalized additive model (GAM) framework. This simulation study showed that GAM is extremely successful at extracting and estimating a health effect embedded in a dataset. It also shows that, if the objective in mind is to estimate the health signal but not to fully explain this signal, a simple GAM model with a single confounder (calendar time) whose smooth representation includes a sufficient number of constraints is as good as a more complex model.Introduction. In the context of wavelet regression, confounding occurs when two or more independent variables interact with the dependent variable at the same frequency. Confounding also acts on a variety of time scales, changing the PM2.5 coefficient (magnitude and sign) and its significance ac

13. How Safe Are Color Additives?

MedlinePlus

... Home For Consumers Consumer Updates How Safe are Color Additives? Share Tweet Linkedin Pin it More sharing ... Consumer Updates RSS Feed Download PDF (380 K) Color additives give the red tint to your fruit ...

14. Cognitive Variables in Problem Solving: A Nonlinear Approach

ERIC Educational Resources Information Center

Stamovlasis, Dimitrios; Tsaparlis, Georgios

2005-01-01

We employ tools of complexity theory to examine the effect of cognitive variables, such as working-memory capacity, degree of field dependence-independence, developmental level and the mobility-fixity dimension. The nonlinear method correlates the subjects' rank-order achievement scores with each cognitive variable. From the achievement scores in…

15. Causal Models with Unmeasured Variables: An Introduction to LISREL.

ERIC Educational Resources Information Center

Wolfle, Lee M.

Whenever one uses ordinary least squares regression, one is making an implicit assumption that all of the independent variables have been measured without error. Such an assumption is obviously unrealistic for most social data. One approach for estimating such regression models is to measure implied coefficients between latent variables for which…

16. Variability as an Operant?

ERIC Educational Resources Information Center

Holth, Per

2012-01-01

A series of experiments on operant variability by Neuringer and colleagues (e.g., Neuringer, 1986, 2002; Page & Neuringer, 1985) have been repeatedly cited as showing that behavioral variability can be reinforced by making reinforcement contingent on it. They showed that the degree of variability in pigeons' eight-peck sequences, as measured by U…

17. Variable rate irrigation (VRI)

Technology Transfer Automated Retrieval System (TEKTRAN)

Variable rate irrigation (VRI) technology is now offered by all major manufacturers of moving irrigation systems, mostly on center pivot irrigation systems. Variable irrigation depths may be controlled by sector only, in which case only the speed of the irrigation lateral is regulated. Or, variable ...

18. Detergent Additive for Lubricating Oils,

DTIC Science & Technology

The Russian patent pertains to a method of producing additives for lubricating oils . A method is known for producing an antiwear additive for... lubricating oils by processing phenols with phosphorus oxychloride, phosphoric acid esters are obtained. In order to give the additive detergent properties

19. Estimation of Baroreflex Function Using Independent Component Analysis of Photoplethysmography

NASA Astrophysics Data System (ADS)

Abe, Makoto; Yoshizawa, Makoto; Sugita, Norihiro; Tanaka, Akira; Homma, Noriyasu; Yambe, Tomoyuki; Nitta, Shin-Ichi

The maximum cross-correlation coefficient ρmax between blood pressure variability and heart rate variability, whose frequency components are limited to the Mayer wave-related band, is a useful index to evaluate the state of the autonomic nervous function related to baroreflex. However, measurement of continuous blood pressure with an expensive and bulky measuring device is required to calculate ρmax. The present study has proposed an easier method for obtaining ρmax with measurement of finger photoplethysmography (PPG) only. In the proposed method, independent components are extracted from feature variables specifying the PPG signal by using the independent component analysis (ICA), and then the most appropriate component is chosen out of them so that the ρmax calculated from the component can approximate its true value. The results from the experiment with a postural change performed in 18 healthy subjects have suggested that the proposed method is available for estimating ρmax by using the ICA to extract blood pressure information from the PPG signal.

20. Incorporation of additives into polymers

DOEpatents

McCleskey, T. Mark; Yates, Matthew Z.

2003-07-29

There has been invented a method for incorporating additives into polymers comprising: (a) forming an aqueous or alcohol-based colloidal system of the polymer; (b) emulsifying the colloidal system with a compressed fluid; and (c) contacting the colloidal polymer with the additive in the presence of the compressed fluid. The colloidal polymer can be contacted with the additive by having the additive in the compressed fluid used for emulsification or by adding the additive to the colloidal system before or after emulsification with the compressed fluid. The invention process can be carried out either as a batch process or as a continuous on-line process.

1. [Hypertensive urgency or high blood pressure variability?

PubMed

Rodionov, A V

2017-01-01

Hypertensive urgency (HU) is a common reason particularly for elderly patients to seek medical advice. Severe asymptomatic hypertension and situational high blood pressure (BP) in patients with its high variability is frequently taken as HU. The use of short-acting antihypertensive drugs is not only indicated in these situations, but it may also increase the risk of cardiovascular events (CVE). Over the past decade, increased BP variability is an independent predictor for a higher risk of CVE. Among the major groups of antihypertensive drugs, there are calcium antagonists, mainly amlodipine, which has the greatest potential to reduce BP variability. Thus, calcium antagonists can be considered as first-line drugs for patients with high BP variability.

2. Why a variable G. [strong equivalence principle applied to study of variable G star

NASA Technical Reports Server (NTRS)

Canuto, V. M.; Goldman, I.

1982-01-01

An attempt is made to put the possible time variability of G in a broader context. It is suggested that the variable G is a popular and incomplete representation of the problem of the validity of the strong equivalence principle (SEP). Particular reference is made to a reanalysis of Viking Mars data to study, in a model independent way, the influence of atomic clocks in recording purely gravitational phenomena. These data ought to provide the most reliable test of the variability of G and the validity of the SEP.

3. Predicting the stroke patient's ability to live independently.

PubMed

DeJong, G; Branch, L G

1982-01-01

The objective of this paper is to identify those variables that best predict a stroke patient's ability to live independently following his/her discharge from medical rehabilitation. The paper draws heavily on a formal research model grounded in independent living (IL) theory. Independent living is defined and operationalized as (1) the patient's ability to live in a nonrestrictive environment and (2) the patient's ability to live productively--not only in terms of gainful employment but also in terms of other contributions to community and family life. The main data source for the study is an extensive computer file of 84 stroke patients discharged from 8 medical rehabilitation centers. The multivariate statistical analysis indicates that 56 to 80 percent of the variance in a patient's ability to live independently can be explained or predicted mainly by the patient's marital status, age, Barthel score, communication impairments, and the ability to get into a motor vehicle. The paper concludes by discussing the implications of the findings for medical rehabilitation and public policy.

4. Additive manufacturing of optical components

NASA Astrophysics Data System (ADS)

Heinrich, Andreas; Rank, Manuel; Maillard, Philippe; Suckow, Anne; Bauckhage, Yannick; Rößler, Patrick; Lang, Johannes; Shariff, Fatin; Pekrul, Sven

2016-08-01

The development of additive manufacturing methods has enlarged rapidly in recent years. Thereby, the work mainly focuses on the realization of mechanical components, but the additive manufacturing technology offers a high potential in the field of optics as well. Owing to new design possibilities, completely new solutions are possible. This article briefly reviews and compares the most important additive manufacturing methods for polymer optics. Additionally, it points out the characteristics of additive manufactured polymer optics. Thereby, surface quality is of crucial importance. In order to improve it, appropriate post-processing steps are necessary (e.g. robot polishing or coating), which will be discussed. An essential part of this paper deals with various additive manufactured optical components and their use, especially in optical systems for shape metrology (e.g. borehole sensor, tilt sensor, freeform surface sensor, fisheye lens). The examples should demonstrate the potentials and limitations of optical components produced by additive manufacturing.

5. Independent Structural Domains in Paramyxovirus Polymerase Protein*

PubMed Central

Dochow, Melanie; Krumm, Stefanie A.; Crowe, James E.; Moore, Martin L.; Plemper, Richard K.

2012-01-01

All enzymatic activities required for genomic replication and transcription of nonsegmented negative strand RNA viruses (or Mononegavirales) are believed to be concentrated in the viral polymerase (L) protein. However, our insight into the organization of these different enzymatic activities into a bioactive tertiary structure remains rudimentary. Fragments of Mononegavirales polymerases analyzed to date cannot restore bioactivity through trans-complementation, unlike the related L proteins of segmented NSVs. We investigated the domain organization of phylogenetically diverse Paramyxovirus L proteins derived from measles virus (MeV), Nipah virus (NiV), and respiratory syncytial virus (RSV). Through a comprehensive in silico and experimental analysis of domain intersections, we defined MeV L position 615 as an interdomain candidate in addition to the previously reported residue 1708. Only position 1708 of MeV and the homologous positions in NiV and RSV L also tolerated the insertion of epitope tags. Splitting of MeV L at residue 1708 created fragments that were unable to physically interact and trans-complement, but strikingly, these activities were reconstituted by the addition of dimerization tags to the fragments. Equivalently split fragments of NiV, RSV, and MeV L oligomerized with comparable efficiency in all homo- and heterotypic combinations, but only the homotypic pairs were able to trans-complement. These results demonstrate that synthesis as a single polypeptide is not required for the Mononegavirales polymerases to adopt a proper tertiary conformation. Paramyxovirus polymerases are composed of at least two truly independent folding domains that lack a traditional interface but require molecular compatibility for bioactivity. The functional probing of the L domain architecture through trans-complementation is anticipated to be applicable to all Mononegavirales polymerases. PMID:22215662

6. Renal electrolyte circadian rhythms - Independence from feeding and activity patterns

NASA Technical Reports Server (NTRS)

Moore-Ede, M. C.; Herd, J. A.

1977-01-01

Experiments were conducted on six unanesthetized chair-acclimatized adult male squirrel monkeys (Saimiri sciureus) weighing 600-900 g to determine whether internal synchronization is the result of simple passive dependence of renal excretory rhythms on endogenous rhythms of those variable that influence electrolyte excretion such as dietary intake and muscular activity. Independence of the urinary rhythms from diurnal variations in feeding, drinking, and activity was secured by depriving the animals of food, water, and training them to perform a two-hourly schedule of feeding, drinking, and activity throughout day and night. Results indicate that the internal synchronization which is normally observed between the behavioral and urinary rhythms cannot be explained by any direct dependence of renal function on behavioral patterns. The most probable mechanism for circadian internal synchronization is that the various behavioral and renal rhythms are controlled by potentially independent separate oscillators which are normally kept in synchrony with one another.

7. Intertrial coherence and causal interaction among independent EEG components.

PubMed

Zervakis, M; Michalopoulos, K; Iordanidou, V; Sakkalis, V

2011-04-30

Over the past few years there has been an increased interest in studying the underlying neural mechanism of attention and cognitive brain activity. This paper aims towards identifying and analyzing distinct responses in an auditory working memory paradigm, as independent components with variable latency, frequency and phase characteristics. The event-related nature of components (either phase or non-phase-locked) over multiple trials is thoroughly examined through intertrial coherence measures. Furthermore, the functional coupling of independent components is investigated through the concept of partial directed coherence depicted as a directed graph. Using these tools, the paper compares issues of activation, connectivity and directionality in the synchronization maps of two populations, of control and Alzheimer's subjects. The results on real data from an oddball experiment verify and further enhance the findings of previous studies and illustrate the potential of the proposed analysis framework.

8. Image classification independent of orientation and scale

NASA Astrophysics Data System (ADS)

Arsenault, Henri H.; Parent, Sebastien; Moisan, Sylvain

1998-04-01

The recognition of targets independently of orientation has become fairly well developed in recent years for in-plane rotation. The out-of-plane rotation problem is much less advanced. When both out-of-plane rotations and changes of scale are present, the problem becomes very difficult. In this paper we describe our research on the combined out-of- plane rotation problem and the scale invariance problem. The rotations were limited to rotations about an axis perpendicular to the line of sight. The objects to be classified were three kinds of military vehicles. The inputs used were infrared imagery and photographs. We used a variation of a method proposed by Neiberg and Casasent, where a neural network is trained with a subset of the database and a minimum distances from lines in feature space are used for classification instead of nearest neighbors. Each line in the feature space corresponds to one class of objects, and points on one line correspond to different orientations of the same target. We found that the training samples needed to be closer for some orientations than for others, and that the most difficult orientations are where the target is head-on to the observer. By means of some additional training of the neural network, we were able to achieve 100% correct classification for 360 degree rotation and a range of scales over a factor of five.

9. Independent evolution of four heme peroxidase superfamilies.

PubMed

Zámocký, Marcel; Hofbauer, Stefan; Schaffner, Irene; Gasselhuber, Bernhard; Nicolussi, Andrea; Soudi, Monika; Pirker, Katharina F; Furtmüller, Paul G; Obinger, Christian

2015-05-15

Four heme peroxidase superfamilies (peroxidase-catalase, peroxidase-cyclooxygenase, peroxidase-chlorite dismutase and peroxidase-peroxygenase superfamily) arose independently during evolution, which differ in overall fold, active site architecture and enzymatic activities. The redox cofactor is heme b or posttranslationally modified heme that is ligated by either histidine or cysteine. Heme peroxidases are found in all kingdoms of life and typically catalyze the one- and two-electron oxidation of a myriad of organic and inorganic substrates. In addition to this peroxidatic activity distinct (sub)families show pronounced catalase, cyclooxygenase, chlorite dismutase or peroxygenase activities. Here we describe the phylogeny of these four superfamilies and present the most important sequence signatures and active site architectures. The classification of families is described as well as important turning points in evolution. We show that at least three heme peroxidase superfamilies have ancient prokaryotic roots with several alternative ways of divergent evolution. In later evolutionary steps, they almost always produced highly evolved and specialized clades of peroxidases in eukaryotic kingdoms with a significant portion of such genes involved in coding various fusion proteins with novel physiological functions.

10. Hybrid Scheduling Model for Independent Grid Tasks

PubMed Central

Shanthini, J.; Kalaikumaran, T.; Karthik, S.

2015-01-01

Grid computing facilitates the resource sharing through the administrative domains which are geographically distributed. Scheduling in a distributed heterogeneous environment is intrinsically very hard because of the heterogeneous nature of resource collection. Makespan and tardiness are two different measures of scheduling, and many of the previous researches concentrated much on reduction of makespan, which measures the machine utilization. In this paper, we propose a hybrid scheduling algorithm for scheduling independent grid tasks with the objective of reducing total weighted tardiness of grid tasks. Tardiness is to measure the due date performance, which has a direct impact on cost for executing the jobs. In this paper we propose BG_ATC algorithm which is a combination of best gap (BG) search and Apparent Tardiness Cost (ATC) indexing algorithm. Furthermore, we implemented these two algorithms in two different phases of the scheduling process. In addition to that, the comparison was made on results with various benchmark algorithms and the experimental results show that our algorithm outperforms the benchmark algorithms. PMID:26543897

11. Calmodulin independence of human duodenal adenylate cyclase.

PubMed Central

Smith, J A; Griffin, M; Mireylees, S E; Long, R G

1991-01-01

The calmodulin and calcium dependence of human adenylate cyclase from the second part of the duodenum was assessed in washed particulate preparations of biopsy specimens by investigating (a) the concentration dependent effects of free [Ca2+] on enzyme activity, (b) the effects of exogenous calmodulin on enzyme activity in ethylene glycol bis (b-aminoethyl ether)N,N'-tetra-acetic acid (EGTA) washed particulate preparations, and (c) the effects of calmodulin antagonists on enzyme activity. Both basal (IC50 = 193.75 (57.5) nmol/l (mean (SEM)) and NaF stimulated (IC50 = 188.0 (44.0) nmol/l) adenylate cyclase activity was strongly inhibited by free [Ca2+] greater than 90 nmol/l. Free [Ca2+] less than 90 nmol/l had no effect on adenylate cyclase activity. NaF stimulated adenylate cyclase activity was inhibited by 50% at 2.5 mmol/l EGTA. This inhibition could not be reversed by free Ca2+. The addition of exogenous calmodulin to EGTA (5 mmol/l) washed particulate preparations failed to stimulate adenylate cyclase activity. Trifluoperazine and N-(8-aminohexyl)-5-IODO-1-naphthalene-sulphonamide (IODO 8) did not significantly inhibit basal and NaF stimulated adenylate cyclase activity when measured at concentrations of up to 100 mumol/l. These results suggest that human duodenal adenylate cyclase activity is calmodulin independent but is affected by changes in free [Ca2+]. PMID:1752461

12. Source-Independent Quantum Random Number Generation

NASA Astrophysics Data System (ADS)

Cao, Zhu; Zhou, Hongyi; Yuan, Xiao; Ma, Xiongfeng

2016-01-01

Quantum random number generators can provide genuine randomness by appealing to the fundamental principles of quantum mechanics. In general, a physical generator contains two parts—a randomness source and its readout. The source is essential to the quality of the resulting random numbers; hence, it needs to be carefully calibrated and modeled to achieve information-theoretical provable randomness. However, in practice, the source is a complicated physical system, such as a light source or an atomic ensemble, and any deviations in the real-life implementation from the theoretical model may affect the randomness of the output. To close this gap, we propose a source-independent scheme for quantum random number generation in which output randomness can be certified, even when the source is uncharacterized and untrusted. In our randomness analysis, we make no assumptions about the dimension of the source. For instance, multiphoton emissions are allowed in optical implementations. Our analysis takes into account the finite-key effect with the composable security definition. In the limit of large data size, the length of the input random seed is exponentially small compared to that of the output random bit. In addition, by modifying a quantum key distribution system, we experimentally demonstrate our scheme and achieve a randomness generation rate of over 5 ×103 bit /s .

13. Nova-like variables

NASA Technical Reports Server (NTRS)

1993-01-01

On grounds of different observable characteristics five classes of nova-like objects are distinguished: the UX Ursae Majoris stars, the antidwarf novae, the DQ Herculis stars, the AM Herculis stars, and the AM Canum Venaticorum stars. Some objects have not been classified specifically. Nova-like stars share most observable features with dwarf novae, except for the outburst behavior. The understanding is that dwarf novae, UX Ursae Majoris stars, and anti-dwarf novae are basically the same sort of objects. The difference between them is that in UX Ursae Majoris stars the mass transfer through the accretion disc always is high so the disc is stationary all the time; in anti-dwarf novae for some reason the mass transfer occasionally drops considerably for some time, and in dwarf novae it is low enough for the disc to undergo semiperiodic changes between high and low accretion events. DQ Herculis stars are believed to possess weakly magnetic white dwarfs which disrupt the inner disc at some distance from the central star; the rotation of the white dwarf can be seen as an additional photometric period. In AM Herculis stars, a strongly magnetic white dwarf entirely prevents the formation of an accretion disk and at the same time locks the rotation of the white dwarf to the binary orbit. Finally, AM Canum Venaticorum stars are believed to be cataclysmic variables that consist of two white dwarf components.

14. Common Variable Immunodeficiency.

PubMed

Saikia, Biman; Gupta, Sudhir

2016-04-01

Common variable immunodeficiency (CVID) is the most common primary immunodeficiency of young adolescents and adults which also affects the children. The disease remains largely under-diagnosed in India and Southeast Asian countries. Although in majority of cases it is sporadic, disease may be inherited in a autosomal recessive pattern and rarely, in autosomal dominant pattern. Patients, in addition to frequent sino-pulmonary infections, are also susceptible to various autoimmune diseases and malignancy, predominantly lymphoma and leukemia. Other characteristic lesions include lymphocytic and granulomatous interstitial lung disease, and nodular lymphoid hyperplasia of gut. Diagnosis requires reduced levels of at least two immunoglobulin isotypes: IgG with IgA and/or IgM and impaired specific antibody response to vaccines. A number of gene mutations have been described in CVID; however, these genetic alterations account for less than 20% of cases of CVID. Flow cytometry aptly demonstrates a disturbed B cell homeostasis with reduced or absent memory B cells and increased CD21(low) B cells and transitional B cell populations. Approximately one-third of patients with CVID also display T cell functional defects. Immunoglobulin therapy remains the mainstay of treatment. Immunologists and other clinicians in India and other South East Asian countries need to be aware of CVID so that early diagnosis can be made, as currently, majority of these patients still go undiagnosed.

15. Some new addition formulae for Weierstrass elliptic functions

PubMed Central

Eilbeck, J. Chris; England, Matthew; Ônishi, Yoshihiro

2014-01-01

We present new addition formulae for the Weierstrass functions associated with a general elliptic curve. We prove the structure of the formulae in n-variables and give the explicit addition formulae for the 2- and 3-variable cases. These new results were inspired by new addition formulae found in the case of an equianharmonic curve, which we can now observe as a specialization of the results here. The new formulae, and the techniques used to find them, also follow the recent work for the generalization of Weierstrass functions to curves of higher genus. PMID:25383018

16. Bayesian Estimation of Conditional Independence Graphs Improves Functional Connectivity Estimates

PubMed Central

Hinne, Max; Janssen, Ronald J.; Heskes, Tom; van Gerven, Marcel A.J.

2015-01-01

Functional connectivity concerns the correlated activity between neuronal populations in spatially segregated regions of the brain, which may be studied using functional magnetic resonance imaging (fMRI). This coupled activity is conveniently expressed using covariance, but this measure fails to distinguish between direct and indirect effects. A popular alternative that addresses this issue is partial correlation, which regresses out the signal of potentially confounding variables, resulting in a measure that reveals only direct connections. Importantly, provided the data are normally distributed, if two variables are conditionally independent given all other variables, their respective partial correlation is zero. In this paper, we propose a probabilistic generative model that allows us to estimate functional connectivity in terms of both partial correlations and a graph representing conditional independencies. Simulation results show that this methodology is able to outperform the graphical LASSO, which is the de facto standard for estimating partial correlations. Furthermore, we apply the model to estimate functional connectivity for twenty subjects using resting-state fMRI data. Results show that our model provides a richer representation of functional connectivity as compared to considering partial correlations alone. Finally, we demonstrate how our approach can be extended in several ways, for instance to achieve data fusion by informing the conditional independence graph with data from probabilistic tractography. As our Bayesian formulation of functional connectivity provides access to the posterior distribution instead of only to point estimates, we are able to quantify the uncertainty associated with our results. This reveals that while we are able to infer a clear backbone of connectivity in our empirical results, the data are not accurately described by simply looking at the mode of the distribution over connectivity. The implication of this is that

17. Halo-independent direct detection analyses without mass assumptions

SciTech Connect

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan; McCullough, Matthew

2015-10-06

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the m{sub χ}−σ{sub n} plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the v{sub min}−g-tilde plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from v{sub min} to nuclear recoil momentum (p{sub R}), the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call h-til-tilde(p{sub R}). The entire family of conventional halo-independent g-tilde(v{sub min}) plots for all DM masses are directly found from the single h-tilde(p{sub R}) plot through a simple rescaling of axes. By considering results in h-tilde(p{sub R}) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple g-tilde(v{sub min}) plots for different DM masses. We conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.

18. Halo-independent direct detection analyses without mass assumptions

DOE PAGES

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan; ...

2015-10-06

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the mχ – σn plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the vmin – g~ plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from vmin to nuclear recoil momentum (pR),more » the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call tilde h(pR). The entire family of conventional halo-independent tilde g~(vmin) plots for all DM masses are directly found from the single tilde h~(pR) plot through a simple rescaling of axes. By considering results in tildeh~(pR) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple tilde g~(vmin) plots for different DM masses. As a result, we conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.« less

19. Halo-independent direct detection analyses without mass assumptions

SciTech Connect

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan; McCullough, Matthew

2015-10-06

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the mχ – σn plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the vmin – g~ plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from vmin to nuclear recoil momentum (pR), the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call tilde h(pR). The entire family of conventional halo-independent tilde g~(vmin) plots for all DM masses are directly found from the single tilde h~(pR) plot through a simple rescaling of axes. By considering results in tildeh~(pR) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple tilde g~(vmin) plots for different DM masses. As a result, we conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.

20. Halo-independent direct detection analyses without mass assumptions

SciTech Connect

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan; McCullough, Matthew E-mail: pjfox@fnal.gov E-mail: matthew.mccullough@cern.ch

2015-10-01

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the m{sub χ}−σ{sub n} plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the v{sub min}− g-tilde plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from v{sub min} to nuclear recoil momentum (p{sub R}), the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call h-tilde (p{sub R}). The entire family of conventional halo-independent g-tilde (v{sub min}) plots for all DM masses are directly found from the single h-tilde (p{sub R}) plot through a simple rescaling of axes. By considering results in h-tilde (p{sub R}) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple g-tilde (v{sub min}) plots for different DM masses. We conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.

1. Halo-independent direct detection analyses without mass assumptions

NASA Astrophysics Data System (ADS)

Anderson, Adam J.; Fox, Patrick J.; Kahn, Yonatan; McCullough, Matthew

2015-10-01

Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the mχ-σn plane. Recently methods which are independent of the DM halo velocity distribution have been developed which present results in the vmin-tilde g plane, but these in turn require an assumption on the dark matter mass. Here we present an extension of these halo-independent methods for dark matter direct detection which does not require a fiducial choice of the dark matter mass. With a change of variables from vmin to nuclear recoil momentum (pR), the full halo-independent content of an experimental result for any dark matter mass can be condensed into a single plot as a function of a new halo integral variable, which we call tilde h(pR). The entire family of conventional halo-independent tilde g(vmin) plots for all DM masses are directly found from the single tilde h(pR) plot through a simple rescaling of axes. By considering results in tilde h(pR) space, one can determine if two experiments are inconsistent for all masses and all physically possible halos, or for what range of dark matter masses the results are inconsistent for all halos, without the necessity of multiple tilde g(vmin) plots for different DM masses. We conduct a sample analysis comparing the CDMS II Si events to the null results from LUX, XENON10, and SuperCDMS using our method and discuss how the results can be strengthened by imposing the physically reasonable requirement of a finite halo escape velocity.

2. ErpICASSO: a tool for reliability estimates of independent components in EEG event-related analysis.

PubMed

Artoni, Fiorenzo; Gemignani, Angelo; Sebastiani, Laura; Bedini, Remo; Landi, Alberto; Menicucci, Danilo

2012-01-01

Independent component analysis and blind source separation methods are steadily gaining popularity for separating individual brain and non-brain source signals mixed by volume conduction in electroencephalographic data. Despite the advancements on these techniques, determining the number of embedded sources and their reliability are still open issues. In particular to date no method takes into account trial-to-trial variability in order to provide a reliability measure of independent components extracted in Event Related Potentials (ERPs) studies. In this work we present ErpICASSO, a new method which modifies a data-driven approach named ICASSO for the analysis of trials (epochs). In addition to ICASSO the method enables the user to estimate the number of embedded sources, and provides a quality index of each extracted ERP component by combining trial-to-trial bootstrapping and CCA projection. We applied ErpICASSO on ERPs recorded from 14 subjects presented with unpleasant and neutral pictures. We separated potentials putatively related to different systems and identified the four primary ERP independent sources. Standing on the confidence interval estimated by ErpICASSO, we were able to compare the components between neutral and unpleasant conditions. ErpICASSO yielded encouraging results, thus providing the scientific community with a useful tool for ICA signal processing whenever dealing with trials recorded in different conditions.

3. Efficient Markov Network Structure Discovery Using Independence Tests

PubMed Central

Bromberg, Facundo; Margaritis, Dimitris; Honavar, Vasant

2011-01-01

We present two algorithms for learning the structure of a Markov network from data: GSMN* and GSIMN. Both algorithms use statistical independence tests to infer the structure by successively constraining the set of structures consistent with the results of these tests. Until very recently, algorithms for structure learning were based on maximum likelihood estimation, which has been proved to be NP-hard for Markov networks due to the difficulty of estimating the parameters of the network, needed for the computation of the data likelihood. The independence-based approach does not require the computation of the likelihood, and thus both GSMN* and GSIMN can compute the structure efficiently (as shown in our experiments). GSMN* is an adaptation of the Grow-Shrink algorithm of Margaritis and Thrun for learning the structure of Bayesian networks. GSIMN extends GSMN* by additionally exploiting Pearl’s well-known properties of the conditional independence relation to infer novel independences from known ones, thus avoiding the performance of statistical tests to estimate them. To accomplish this efficiently GSIMN uses the Triangle theorem, also introduced in this work, which is a simplified version of the set of Markov axioms. Experimental comparisons on artificial and real-world data sets show GSIMN can yield significant savings with respect to GSMN*, while generating a Markov network with comparable or in some cases improved quality. We also compare GSIMN to a forward-chaining implementation, called GSIMN-FCH, that produces all possible conditional independences resulting from repeatedly applying Pearl’s theorems on the known conditional independence tests. The results of this comparison show that GSIMN, by the sole use of the Triangle theorem, is nearly optimal in terms of the set of independences tests that it infers. PMID:22822297

4. The SCN-independent clocks, methamphetamine and food restriction.

PubMed

Honma, Ken-ichi; Honma, Sato

2009-11-01

The circadian system in mammals consists of the central clock in the hypothalamic suprachiasmatic nucleus (SCN) and the peripheral clocks in a variety of tissues and organs. The SCN clock entrains to a light-dark cycle and resets the peripheral clocks. In addition, there are at least two other clocks in the circadian domain which are independent of the SCN and which entrain to nonphotic time cues: methamphetamine (MAP)-induced and restricted daily feeding (RF)-induced clocks. Neither the site nor the mechanism of SCN-independent clocks is known. Canonical clock genes for circadian oscillation are not required for the expression of either SCN-independent rhythm. The central catecholaminergic system is probably involved in the expression of the SCN-independent rhythms, especially of the MAP-induced rhythm. MAP-induced activity rhythms in rats and the sleep-wake cycles in humans share unique phenomena such as spontaneous internal desynchronization, circabidian rhythm and nonphotic entrainment, suggesting overlapping oscillatory mechanisms. The SCN-independent clock is an adaptation that regulates behavior in response to nonphotic time cues, and seems to be closely related to the arousal mechanism.

5. Independent Long Fingers are not Essential for a Grasping Hand

PubMed Central

Montagnani, Federico; Controzzi, Marco; Cipriani, Christian

2016-01-01

The human hand is a complex integrated system with motor and sensory components that provides individuals with high functionality and elegant behaviour. In direct connection with the brain, the hand is capable of performing countless actions ranging from fine digit manipulation to the handling of heavy objects. However the question of which movements mostly contribute to the manipulation skills of the hand, and thus should be included in prosthetic hands, is yet to be answered. Building from our previous work, and assuming that a hand with independent long fingers allowed performance comparable to a hand with coupled fingers, here we explored the actual contribution of independent fingers while performing activities of daily living using custom built orthoses. Our findings show that, when an opposable thumb is present, independent long fingers provide a measureable advantage in performing activities of daily living only when precision grasps are involved. In addition, the results suggest that the remarkable grasping skills of the human hand rely more on the independent abduction/adduction of the fingers than on their independent flexion/extension. These findings are of interest to the designers of artificial hands, including biomimetic prostheses and exoskeletons. PMID:27759046

6. Development Factors and Field Dependence-Independence.

DTIC Science & Technology

1984-11-01

The use of field dependence -field independence measures has been suggested for both the selection and classification of naval aviators. If measures...of field dependence -field independence are predictive of pilot proficiency, the utility of the construct for selection and classification could be...moderated by the influence of intraindividual changes in field dependence -field independence (FD-FI) over time. This report reviews (1) particulars of the

7. Responses to additional JAPC questions

SciTech Connect

Burke, T.M.

1998-02-03

The goals are to improve performance and reduce costs; the variables tested are fuel fabrication and assembly tolerances and cladding materials. Significant results are: goal lifetimes achieved; D9/HT9 alloys superior--reduced swelling potential duct mechanical attachment methods viable; test performance per design predictions.

8. Enantioselective Michael addition of water.

PubMed

Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

2015-02-09

The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry.

9. Enantioselective Michael Addition of Water

PubMed Central

Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

2015-01-01

The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry. PMID:25529526

10. Studying the variability in the Raman signature of writing pen inks.

PubMed

Braz, André; López-López, María; García-Ruiz, Carmen

2014-12-01

This manuscript aims to study the inter and intra brand, model and batch variability in the Raman spectral signature among modern pen inks that will help forensic document examiners during the interpretation process. Results showed that most oil-based samples have similar Raman signatures that are characteristic of the Crystal Violet dye, independently of the brand. Exception was the Pilot samples that use Victoria Pure Blue BO instead. This small inter-brand variability makes oil-based pens difficult to discriminate by brand. On the contrary, gel and liquid-based samples use different colorants such as Rhodamine B, Copper Phthalocyanine, Ethyl Violet and Victoria Blue B. No particular pattern was observed regarding the colorants used by each brand, except the Pilot samples that were the only brand using the Victoria Blue B dye, which is a clear distinct feature. Additionally, the intra-brand variability was also large among gel-based Pilot samples. The small spectral differences observed among several batches of Bic Crystal Medium samples demonstrated that changes were introduced in their chemical formula over the years. The intra-batch variability was small and no spectral differences were observed within batches. This manuscript demonstrates the potential of Raman spectroscopy for discriminating pens inks from different brands and models and even, batches. Additionally, the main colorants used in modern pens were also identified.

11. Some Statistical Strategies for DAE-seq Data Analysis: Variable Selection and Modeling Dependencies among Observations.

PubMed

Rashid, Naim U; Sun, Wei; Ibrahim, Joseph G

2014-01-01

In DAE (DNA After Enrichment)-seq experiments, genomic regions related with certain biological processes are enriched/isolated by an assay and are then sequenced on a high-throughput sequencing platform to determine their genomic positions. Statistical analysis of DAE-seq data aims to detect genomic regions with significant aggregations of isolated DNA fragments ("enriched regions") versus all the other regions ("background"). However, many confounding factors may influence DAE-seq signals. In addition, the signals in adjacent genomic regions may exhibit strong correlations, which invalidate the independence assumption employed by many existing methods. To mitigate these issues, we develop a novel Autoregressive Hidden Markov Model (AR-HMM) to account for covariates effects and violations of the independence assumption. We demonstrate that our AR-HMM leads to improved performance in identifying enriched regions in both simulated and real datasets, especially in those in epigenetic datasets with broader regions of DAE-seq signal enrichment. We also introduce a variable selection procedure in the context of the HMM/AR-HMM where the observations are not independent and the mean value of each state-specific emission distribution is modeled by some covariates. We study the theoretical properties of this variable selection procedure and demonstrate its efficacy in simulated and real DAE-seq data. In summary, we develop several practical approaches for DAE-seq data analysis that are also applicable to more general problems in statistics.

12. Fetal autonomic brain age scores, segmented heart rate variability analysis, and traditional short term variability

PubMed Central

Hoyer, Dirk; Kowalski, Eva-Maria; Schmidt, Alexander; Tetschke, Florian; Nowack, Samuel; Rudolph, Anja; Wallwitz, Ulrike; Kynass, Isabelle; Bode, Franziska; Tegtmeyer, Janine; Kumm, Kathrin; Moraru, Liviu; Götz, Theresa; Haueisen, Jens; Witte, Otto W.; Schleußner, Ekkehard; Schneider, Uwe

2014-01-01

Disturbances of fetal autonomic brain development can be evaluated from fetal heart rate patterns (HRP) reflecting the activity of the autonomic nervous system. Although HRP analysis from cardiotocographic (CTG) recordings is established for fetal surveillance, temporal resolution is low. Fetal magnetocardiography (MCG), however, provides stable continuous recordings at a higher temporal resolution combined with a more precise heart rate variability (HRV) analysis. A direct comparison of CTG and MCG based HRV analysis is pending. The aims of the present study are: (i) to compare the fetal maturation age predicting value of the MCG based fetal Autonomic Brain Age Score (fABAS) approach with that of CTG based Dawes-Redman methodology; and (ii) to elaborate fABAS methodology by segmentation according to fetal behavioral states and HRP. We investigated MCG recordings from 418 normal fetuses, aged between 21 and 40 weeks of gestation. In linear regression models we obtained an age predicting value of CTG compatible short term variability (STV) of R2 = 0.200 (coefficient of determination) in contrast to MCG/fABAS related multivariate models with R2 = 0.648 in 30 min recordings, R2 = 0.610 in active sleep segments of 10 min, and R2 = 0.626 in quiet sleep segments of 10 min. Additionally segmented analysis under particular exclusion of accelerations (AC) and decelerations (DC) in quiet sleep resulted in a novel multivariate model with R2 = 0.706. According to our results, fMCG based fABAS may provide a promising tool for the estimation of fetal autonomic brain age. Beside other traditional and novel HRV indices as possible indicators of developmental disturbances, the establishment of a fABAS score normogram may represent a specific reference. The present results are intended to contribute to further exploration and validation using independent data sets and multicenter research structures. PMID:25505399

13. [The research protocol IV: study variables].

PubMed

Villasís-Keever, Miguel Ángel; Miranda-Novales, María Guadalupe

2016-01-01

The variables in a research study are all that is measured, the information collected, or the data that is collected in order to answer the research questions, which are specified in the objectives. Their selection is essential to the research protocol. This article aims to point out the elements to be considered in the section of the variables. To avoid ambiguity, it is necessary to select only those that will help achieve the study objectives. It should subsequently be defined how they will be measured to ensure that the findings can be replicated; it is therefore desirable to include conceptual and operational definitions. From the methodological point of view, the classification of variables helps us understand how the relationship between them is conceptualized. Depending on the study design, the independent, dependent, universal, and confounding variables should be noted. Another indispensable element for planning statistical analyses is the scale of variable measurement. Therefore, one must specify whether the variables correspond to one of the following four: qualitative nominal, qualitative ordinal, quantitative range, or quantitative ratio. Finally, we should detail the measurement units of each variable.

14. Understanding Brown Dwarf Variability

NASA Technical Reports Server (NTRS)

Marley, Mark S.

2013-01-01

Surveys of brown dwarf variability continue to find that roughly half of all brown dwarfs are variable. While variability is observed amongst all types of brown dwarfs, amplitudes are typically greatest for L-T transition objects. In my talk I will discuss the possible physical mechanisms that are responsible for the observed variability. I will particularly focus on comparing and contrasting the effects of changes in atmospheric thermal profile and cloud opacity. The two different mechanisms will produce different variability signatures and I will discuss the extent to which the current datasets constrain both mechanisms. By combining constraints from studies of variability with existing spectral and photometric datasets we can begin to construct and test self-consistent models of brown dwarf atmospheres. These models not only aid in the interpretation of existing objects but also inform studies of directly imaged giant planets.

15. Color Addition and Subtraction Apps

ERIC Educational Resources Information Center

Ruiz, Frances; Ruiz, Michael J.

2015-01-01

Color addition and subtraction apps in HTML5 have been developed for students as an online hands-on experience so that they can more easily master principles introduced through traditional classroom demonstrations. The evolution of the additive RGB color model is traced through the early IBM color adapters so that students can proceed step by step…

16. Additive Effects on Asymmetric Catalysis.

PubMed

Hong, Liang; Sun, Wangsheng; Yang, Dongxu; Li, Guofeng; Wang, Rui

2016-03-23

This review highlights a number of additives that can be used to make asymmetric reactions perfect. Without changing other reaction conditions, simply adding additives can lead to improved asymmetric catalysis, such as reduced reaction time, improved yield, or/and increased selectivity.

17. Aerosol Variability Observed with Rpas

NASA Astrophysics Data System (ADS)

Altstädter, B.; Lampert, A.; Scholtz, A.; Bange, J.; Platis, A.; Hermann, M.; Wehner, B.

2013-08-01

To observe the origin, vertical and horizontal distribution and variability of aerosol particles, and especially ultrafine particles recently formed, we plan to employ the remotely piloted aircraft system (RPAS) Carolo-P360 "ALADINA" of TU Braunschweig. The goal of the presented project is to investigate the vertical and horizontal distribution, transport and small-scale variability of aerosol particles in the atmospheric boundary layer using RPAS. Two additional RPAS of type MASC of Tübingen University equipped with turbulence instrumentation add the opportunity to study the interaction of the aerosol concentration with turbulent transport and exchange processes of the surface and the atmosphere. The combination of different flight patterns of the three RPAS allows new insights in atmospheric boundary layer processes. Currently, the different aerosol sensors are miniaturized at the Leibniz Institute for Tropospheric Research, Leipzig and together with the TU Braunschweig adapted to fit into the RPAS. Moreover, an additional meteorological payload for measuring temperature, humidity and turbulence properties is constructed by Tübingen University. Two condensation particle counters determine the total aerosol number with a different lower detection threshold in order to investigate the horizontal and vertical aerosol variability and new particle formation (aerosol particles of some nm diameter). Further the aerosol size distribution in the range from about 0.300 to ~5 μm is given by an optical particle counter.

18. Variable frequency microwave moisture leveling

SciTech Connect

Hamann, M.R.

1999-07-01

A variable frequency microwave system was examined to replace an existing carousel resistance heating line as the method for drying of mouth swabs for the pharmaceutical industry. A pharmaceutical manufacturer located in Northern Illinois had a resistive heating system that was not drying product satisfactorily, thus requiring additional ambient drying time even after a 30-minute drying cycle. Since the swabs are used for the healthcare industry, the amount of moisture present after drying was critical to avoid the formation of mold on the product that could have lead to dissatisfied customers. Variable frequency microwave moisture leveling allowed better product quality while turning the manufacturing operation into just in time delivery. During pilot scale testing, a 300 times cycle improvement was realized for variable frequency microwave compared to the conventional carousel resistive drying unit (24 hours to 5 minutes). The projected total cost of the variable frequency microwave system is \$1 million, with 25% of the cost in the microwave unit and 70% of the cost in a new autobagging system. The author projected a \$0.58 million saving per year in reduced operational costs with productivity increases. Although the project would have had a 1.8 year payback time, it was not implemented due to the capital expense and risk of an unknown technology.

19. VARIABLE TIME DELAY MEANS

DOEpatents

Clemensen, R.E.

1959-11-01

An electrically variable time delay line is described which may be readily controlled simuitaneously with variable impedance matching means coupied thereto such that reflections are prevented. Broadly, the delay line includes a signal winding about a magnetic core whose permeability is electrically variable. Inasmuch as the inductance of the line varies directly with the permeability, the time delay and characteristic impedance of the line both vary as the square root of the permeability. Consequently, impedance matching means may be varied similariy and simultaneously w:th the electrically variable permeability to match the line impedance over the entire range of time delay whereby reflections are prevented.

20. Universality of State-Independent Violation of Correlation Inequalities for Noncontextual Theories

SciTech Connect

Badziag, Piotr; Bengtsson, Ingemar; Cabello, Adan; Pitowsky, Itamar

2009-07-31

We show that the state-independent violation of inequalities for noncontextual hidden variable theories introduced in [Phys. Rev. Lett. 101, 210401 (2008)] is universal, i.e., occurs for any quantum mechanical system in which noncontextuality is meaningful. We describe a method to obtain state-independent violations for any system of dimension d>=3. This universality proves that, according to quantum mechanics, there are no 'classical' states.

1. Additively manufactured metallic pentamode meta-materials

NASA Astrophysics Data System (ADS)

Hedayati, R.; Leeflang, A. M.; Zadpoor, A. A.

2017-02-01

Mechanical metamaterials exhibit unusual mechanical properties that originate from their topological design. Pentamode metamaterials are particularly interesting because they could be designed to possess any thermodynamically admissible elasticity tensor. In this study, we additively manufacture the metallic pentamode metamaterials from a biocompatible and mechanically strong titanium alloy (Ti-6Al-4V) using an energy distribution method developed for the powder bed fusion techniques. The mechanical properties of the developed materials were a few orders of magnitude higher than those of the similar topologies fabricated previously from polymers. Moreover, the elastic modulus and yield stress of the presented pentamode metamaterials were decoupled from their relative density, meaning that the metallic meta-biomaterials with independently tailored elastic and mass transport (permeability) properties could be designed for tissue regeneration purposes.

2. Printability of alloys for additive manufacturing

PubMed Central

Mukherjee, T.; Zuback, J. S.; De, A.; DebRoy, T.

2016-01-01

Although additive manufacturing (AM), or three dimensional (3D) printing, provides significant advantages over existing manufacturing techniques, metallic parts produced by AM are susceptible to distortion, lack of fusion defects and compositional changes. Here we show that the printability, or the ability of an alloy to avoid these defects, can be examined by developing and testing appropriate theories. A theoretical scaling analysis is used to test vulnerability of various alloys to thermal distortion. A theoretical kinetic model is used to examine predisposition of different alloys to AM induced compositional changes. A well-tested numerical heat transfer and fluid flow model is used to compare susceptibilities of various alloys to lack of fusion defects. These results are tested and validated with independent experimental data. The findings presented in this paper are aimed at achieving distortion free, compositionally sound and well bonded metallic parts. PMID:26796864

3. Printability of alloys for additive manufacturing

NASA Astrophysics Data System (ADS)

Mukherjee, T.; Zuback, J. S.; de, A.; Debroy, T.

2016-01-01

Although additive manufacturing (AM), or three dimensional (3D) printing, provides significant advantages over existing manufacturing techniques, metallic parts produced by AM are susceptible to distortion, lack of fusion defects and compositional changes. Here we show that the printability, or the ability of an alloy to avoid these defects, can be examined by developing and testing appropriate theories. A theoretical scaling analysis is used to test vulnerability of various alloys to thermal distortion. A theoretical kinetic model is used to examine predisposition of different alloys to AM induced compositional changes. A well-tested numerical heat transfer and fluid flow model is used to compare susceptibilities of various alloys to lack of fusion defects. These results are tested and validated with independent experimental data. The findings presented in this paper are aimed at achieving distortion free, compositionally sound and well bonded metallic parts.

4. Printability of alloys for additive manufacturing.

PubMed

Mukherjee, T; Zuback, J S; De, A; DebRoy, T

2016-01-22

Although additive manufacturing (AM), or three dimensional (3D) printing, provides significant advantages over existing manufacturing techniques, metallic parts produced by AM are susceptible to distortion, lack of fusion defects and compositional changes. Here we show that the printability, or the ability of an alloy to avoid these defects, can be examined by developing and testing appropriate theories. A theoretical scaling analysis is used to test vulnerability of various alloys to thermal distortion. A theoretical kinetic model is used to examine predisposition of different alloys to AM induced compositional changes. A well-tested numerical heat transfer and fluid flow model is used to compare susceptibilities of various alloys to lack of fusion defects. These results are tested and validated with independent experimental data. The findings presented in this paper are aimed at achieving distortion free, compositionally sound and well bonded metallic parts.

5. Printability of alloys for additive manufacturing

SciTech Connect

Mukherjee, T.; Zuback, J. S.; De, A.; DebRoy, T.

2016-01-22

Although additive manufacturing (AM), or three dimensional (3D) printing, provides significant advantages over existing manufacturing techniques, metallic parts produced by AM are susceptible to distortion, lack of fusion defects and compositional changes. Here we show that the printability, or the ability of an alloy to avoid these defects, can be examined by developing and testing appropriate theories. A theoretical scaling analysis is used to test vulnerability of various alloys to thermal distortion. A theoretical kinetic model is used to examine predisposition of different alloys to AM induced compositional changes. A well-tested numerical heat transfer and fluid flow model is used to compare susceptibilities of various alloys to lack of fusion defects. These results are tested and validated with independent experimental data. Here, the findings presented in this paper are aimed at achieving distortion free, compositionally sound and well bonded metallic parts.

6. Printability of alloys for additive manufacturing

DOE PAGES

Mukherjee, T.; Zuback, J. S.; De, A.; ...

2016-01-22

Although additive manufacturing (AM), or three dimensional (3D) printing, provides significant advantages over existing manufacturing techniques, metallic parts produced by AM are susceptible to distortion, lack of fusion defects and compositional changes. Here we show that the printability, or the ability of an alloy to avoid these defects, can be examined by developing and testing appropriate theories. A theoretical scaling analysis is used to test vulnerability of various alloys to thermal distortion. A theoretical kinetic model is used to examine predisposition of different alloys to AM induced compositional changes. A well-tested numerical heat transfer and fluid flow model is usedmore » to compare susceptibilities of various alloys to lack of fusion defects. These results are tested and validated with independent experimental data. Here, the findings presented in this paper are aimed at achieving distortion free, compositionally sound and well bonded metallic parts.« less

7. Teaching the Declaration of Independence. ERIC Digest.

ERIC Educational Resources Information Center

Patrick, John J.

The Declaration of Independence is the founding document of the United States. It is part of the social studies core curriculum in U.S. schools. By the time they graduate from high school, students are expected to know the main ideas in the Declaration of Independence and their significance. This digest discusses: (1) the origins of the…

8. The Public Stake in Independent Higher Education.

ERIC Educational Resources Information Center

Olson, Lawrence

The importance of higher education in providing the skilled labor force needed to respond to changing technologies; the cost-efficiency of independent higher education; and implications for government, industry, and independent higher education are considered. The most readily changing technologies include computers and electronics, satellite…

9. 33 CFR 159.93 - Independent supporting.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Independent supporting. 159.93 Section 159.93 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.93 Independent supporting....

10. 33 CFR 159.93 - Independent supporting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Independent supporting. 159.93 Section 159.93 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.93 Independent supporting....

11. 33 CFR 159.93 - Independent supporting.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Independent supporting. 159.93 Section 159.93 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.93 Independent supporting....

12. 33 CFR 159.93 - Independent supporting.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Independent supporting. 159.93 Section 159.93 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.93 Independent supporting....

13. 33 CFR 159.93 - Independent supporting.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Independent supporting. 159.93 Section 159.93 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.93 Independent supporting....

14. Hiring and Retaining Great Independent School Teachers

ERIC Educational Resources Information Center

Balossi, Matt; Hernández, Natalie R.

2016-01-01

While numerous studies measure teacher effectiveness in public schools, there is little research on teacher quality among independent schools. In fact, the topic of teacher quality in public schools receives widespread media coverage, funding, and special interest. In order to better understand how independent schools describe high-quality…

15. 38 CFR 46.8 - Independent contractors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Independent contractors... contractors. Independent contractors acting on behalf of the Department of Veterans Affairs are subject to the... provide the contractor with notice that a report of a clinical privileges action will be filed with...

16. 46 CFR 62.30-5 - Independence.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Independence. 62.30-5 Section 62.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Reliability and Safety Criteria, All Automated Vital Systems § 62.30-5 Independence. (a) Single...

17. 46 CFR 62.30-5 - Independence.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Independence. 62.30-5 Section 62.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Reliability and Safety Criteria, All Automated Vital Systems § 62.30-5 Independence. (a) Single...

18. 46 CFR 62.30-5 - Independence.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Independence. 62.30-5 Section 62.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Reliability and Safety Criteria, All Automated Vital Systems § 62.30-5 Independence. (a) Single...

19. The Independent Living Behavior Checklist: Experimental Edition.

ERIC Educational Resources Information Center

Walls, Richard T.; And Others

The document describes independent living skills, and provides information on how they can be measured. It is explained in an introductory chapter that the checklist is an extensive list of 343 independent living skill objectives specified in terms of conditions (antecedents or givens), behaviors, and standards. Objectives are classified and…

20. 29 CFR 785.30 - Independent training.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Independent training. 785.30 Section 785.30 Labor... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS HOURS WORKED Application of Principles Lectures, Meetings and Training Programs § 785.30 Independent training. Of course, if an employee on...

1. 29 CFR 785.30 - Independent training.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Independent training. 785.30 Section 785.30 Labor... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS HOURS WORKED Application of Principles Lectures, Meetings and Training Programs § 785.30 Independent training. Of course, if an employee on...

2. 29 CFR 785.30 - Independent training.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Independent training. 785.30 Section 785.30 Labor... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS HOURS WORKED Application of Principles Lectures, Meetings and Training Programs § 785.30 Independent training. Of course, if an employee on...

3. 29 CFR 785.30 - Independent training.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Independent training. 785.30 Section 785.30 Labor... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS HOURS WORKED Application of Principles Lectures, Meetings and Training Programs § 785.30 Independent training. Of course, if an employee on...

4. The New Marketing Handbook for Independent Schools.

ERIC Educational Resources Information Center

Boarding Schools, Boston, MA.

Planning coherent, relevant marketing strategies is crucial to the survival of independent education in the United States. This handbook was created for independent school marketers; principals; and development, publications, public relations, and admissions directors. It offers checklists, sidebars, callouts, and summaries that focus on…

5. 12 CFR 34.45 - Appraiser independence.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Appraiser independence. 34.45 Section 34.45 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND APPRAISALS Appraisals § 34.45 Appraiser independence. (a) Staff appraisers. If an appraisal is prepared by...

6. 12 CFR 34.45 - Appraiser independence.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Appraiser independence. 34.45 Section 34.45 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND APPRAISALS Appraisals § 34.45 Appraiser independence. (a) Staff appraisers. If an appraisal is prepared by...

7. 12 CFR 34.45 - Appraiser independence.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Appraiser independence. 34.45 Section 34.45 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND APPRAISALS Appraisals § 34.45 Appraiser independence. (a) Staff appraisers. If an appraisal is prepared by...

8. 12 CFR 34.45 - Appraiser independence.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Appraiser independence. 34.45 Section 34.45 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND APPRAISALS Appraisals § 34.45 Appraiser independence. (a) Staff appraisers. If an appraisal is prepared by...

9. 12 CFR 34.45 - Appraiser independence.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Appraiser independence. 34.45 Section 34.45 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND APPRAISALS Appraisals § 34.45 Appraiser independence. (a) Staff appraisers. If an appraisal is prepared by...

10. 46 CFR 62.30-5 - Independence.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Independence. 62.30-5 Section 62.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Reliability and Safety Criteria, All Automated Vital Systems § 62.30-5 Independence. (a) Single...

11. Teacher's Guide to Independence National Historical Park.

ERIC Educational Resources Information Center

National Park Service (Dept. of Interior), Philadelphia, PA. Independence National Historical Park.

Independence National Historical Park, located in Philadelphia, Pennsylvania, is operated by the National Park Service. The park was authorized by an Act of Congress on June 28, 1948, and formally established on July 4, 1956. The mission of Independence National Historical Park is to preserve its stories, buildings, and artifacts as a source of…

12. Accounting for Independent Schools. Second Edition.

ERIC Educational Resources Information Center

National Association of Independent Schools, Boston, MA.

This is a thoroughly revised edition of the 1969 publication, "Accounting for Independent Schools," a guide that attempted to codify basic accounting principles and practices for specific application to independent schools. The focus of the second edition is more on refining practices than on initiating them, and more on extending the managerial…

13. Independence and Community in Our Schools.

ERIC Educational Resources Information Center

Mallery, David

During the past few years a new trend in day to day schooling has developed, namely independent studies, that involves learning experience between people. This monograph presents the idea that there is a relation between independence in school programs and a desire for "community" (the coming-together of people) which is mutually nourishing.…

14. 29 CFR 785.30 - Independent training.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Independent training. 785.30 Section 785.30 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL... Lectures, Meetings and Training Programs § 785.30 Independent training. Of course, if an employee on...

15. Quantum Interference between independent environments in open quantum systems

NASA Astrophysics Data System (ADS)

Chan, Ching-Kit; Lin, Guin-Dar; Yelin, Susanne; Lukin, Mikhail

2014-03-01

When a general quantum system interacts with multiple environments, the environmental effects are usually treated in an additive manner in the master equation. This assumption becomes questionable for non-Markovian environments that have finite memory times. Here, we show that quantum interferences between independent environments exist and can qualitatively modify the dynamics of the reduced physical system. We illustrate this effect with examples of atomic systems coupled to structured reservoirs, and discuss its origin in general using a non-equilibrium diagrammatic technique. The consequential decoherence dynamics cannot be captured by an additive master equation.

16. Statistical mechanics of maximal independent sets

NASA Astrophysics Data System (ADS)

Dall'Asta, Luca; Pin, Paolo; Ramezanpour, Abolfazl

2009-12-01

The graph theoretic concept of maximal independent set arises in several practical problems in computer science as well as in game theory. A maximal independent set is defined by the set of occupied nodes that satisfy some packing and covering constraints. It is known that finding minimum and maximum-density maximal independent sets are hard optimization problems. In this paper, we use cavity method of statistical physics and Monte Carlo simulations to study the corresponding constraint satisfaction problem on random graphs. We obtain the entropy of maximal independent sets within the replica symmetric and one-step replica symmetry breaking frameworks, shedding light on the metric structure of the landscape of solutions and suggesting a class of possible algorithms. This is of particular relevance for the application to the study of strategic interactions in social and economic networks, where maximal independent sets correspond to pure Nash equilibria of a graphical game of public goods allocation.

17. 9. March 1960 FRONT ROOM OF THE ADDITION BUILT BY ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. March 1960 FRONT ROOM OF THE ADDITION BUILT BY JOHN RUSSELL POPE FACING ON MOUNT VERNON PLACE. THIS WAS EITHER A LIBRARY OR A ROOM FOR DISPLAYING TROPHIES OR OBJETS D'ART. THE VIEW IS LOOKING SOUTH, THROUGH A STAIRCASE HALL, TO THE THEATER OR BALLROOM - Garrett-Jacobs House, 7, 9, 11, 13 West Mount Vernon Place, Baltimore, Independent City, MD

18. 5. March 1960 ROOM IN BASEMENT OF THE ADDITION BUILT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. March 1960 ROOM IN BASEMENT OF THE ADDITION BUILT BY JOHN RUSSELL POPE, SUPPER ROOM, LOOKING NORTH 9I.E. IN THE DIRECTION OF MOUNT VERNON PLACE) - Garrett-Jacobs House, 7, 9, 11, 13 West Mount Vernon Place, Baltimore, Independent City, MD

19. Blind separation of convolutive sEMG mixtures based on independent vector analysis

NASA Astrophysics Data System (ADS)

Wang, Xiaomei; Guo, Yina; Tian, Wenyan

2015-12-01

An independent vector analysis (IVA) method base on variable-step gradient algorithm is proposed in this paper. According to the sEMG physiological properties, the IVA model is applied to the frequency-domain separation of convolutive sEMG mixtures to extract motor unit action potentials information of sEMG signals. The decomposition capability of proposed method is compared to the one of independent component analysis (ICA), and experimental results show the variable-step gradient IVA method outperforms ICA in blind separation of convolutive sEMG mixtures.

20. Color Addition and Subtraction Apps

NASA Astrophysics Data System (ADS)

Ruiz, Frances; Ruiz, Michael J.

2015-10-01

Color addition and subtraction apps in HTML5 have been developed for students as an online hands-on experience so that they can more easily master principles introduced through traditional classroom demonstrations. The evolution of the additive RGB color model is traced through the early IBM color adapters so that students can proceed step by step in understanding mathematical representations of RGB color. Finally, color addition and subtraction are presented for the X11 colors from web design to illustrate yet another real-life application of color mixing.

1. Pathogen-Reduced, Platelet Additive Solution, Extended Stored Platelets (PREPS)

DTIC Science & Technology

2015-10-01

trauma patients. References: 1. Slichter SJ, Harker LA. Preparation and storage of platelet concentrates . II. Storage variables influencing ...Storage variables influencing platelet viability and function. Br J Haematol 1976;34(3):403-419. 2. Becker GA, Tuccelli M, Kunicki T, et al. Studies of...platelet additive solution (PAS) to extend the life of stored platelets. Our project also aims to determine how long acceptable platelet viability can be

2. Chromospheric variability of M giant semiregular variables

NASA Astrophysics Data System (ADS)

Eaton, Joel A.; Johnson, Hollis R.; Cadmus, Robert R., Jr.

1990-11-01

The results of monitoring the chromospheric emission from three M giant semiregular variables, W Cyg, NU Pav, and Theta Aps at low dispersion with the IUE satellite are reported along with high-dispersion IUE spectra for R Lyr and Delta(2) Lyr. The chromospheric emission is variable in all of the first three stars, and the Mg II strength generally follows changes in the continuum. However, the changes are not directly proportional, and there is a phase lag between the emission in the continuum and that in the Mg II lines, at least in W Cyg and probably in NU Pav. R Lyr showed changes in Mg II lines strengths and profiles uncorrelated with Al II 2669 A strength or with the strengths of fluorescent Fe I lines. The chromospheres of all these stars are clearly modified by stellar pulsation. The position and extent of the emitting layers of the chromospheres of the stars are estimated.

3. Using an instrumental variable to test for unmeasured confounding

PubMed Central

Guo, Zijian; Cheng, Jing; Lorch, Scott A.; Small, Dylan S.

2014-01-01

An important concern in an observational study is whether or not there is unmeasured confounding, that is, unmeasured ways in which the treatment and control groups differ before treatment which affect the outcome. We develop a test of whether there is unmeasured confounding when an instrumental variable (IV) is available. An IV is a variable that is independent of the unmeasured confounding and encourages a subject to take one treatment level versus another, while having no effect on the outcome beyond its encouragement of a certain treatment level. We show what types of unmeasured confounding can be tested for with an IV and develop a test for this type of unmeasured confounding that has correct type I error rate. We show that the widely used Durbin–Wu–Hausman test can have inflated type I error rates when there is treatment effect heterogeneity. Additionally, we show that our test provides more insight into the nature of the unmeasured confounding than the Durbin–Wu–Hausman test. We apply our test to an observational study of the effect of a premature infant being delivered in a high-level neonatal intensive care unit (one with mechanical assisted ventilation and high volume) versus a lower level unit, using the excess travel time a mother lives from the nearest high-level unit to the nearest lower-level unit as an IV. PMID:24930696

4. RosettaAntibody: antibody variable region homology modeling server.

PubMed

Sircar, Aroop; Kim, Eric T; Gray, Jeffrey J

2009-07-01

The RosettaAntibody server (http://antibody.graylab.jhu.edu) predicts the structure of an antibody variable region given the amino-acid sequences of the respective light and heavy chains. In an initial stage, the server identifies and displays the most sequence homologous template structures for the light and heavy framework regions and each of the complementarity determining region (CDR) loops. Subsequently, the most homologous templates are assembled into a side-chain optimized crude model, and the server returns a picture and coordinate file. For users requesting a high-resolution model, the server executes the full RosettaAntibody protocol which additionally models the hyper-variable CDR H3 loop. The high-resolution protocol also relieves steric clashes by optimizing the CDR backbone torsion angles and by simultaneously perturbing the relative orientation of the light and heavy chains. RosettaAntibody generates 2000 independent structures, and the server returns pictures, coordinate files, and detailed scoring information for the 10 top-scoring models. The 10 models enable users to use rational judgment in choosing the best model or to use the set as an ensemble for further studies such as docking. The high-resolution models generated by RosettaAntibody have been used for the successful prediction of antibody-antigen complex structures.

5. Interannual variability in ozone removal by a temperate deciduous forest

NASA Astrophysics Data System (ADS)

Clifton, O. E.; Fiore, A. M.; Munger, J. W.; Malyshev, S.; Horowitz, L. W.; Shevliakova, E.; Paulot, F.; Murray, L. T.; Griffin, K. L.

2017-01-01

The ozone (O3) dry depositional sink and its contribution to observed variability in tropospheric O3 are both poorly understood. Distinguishing O3 uptake through plant stomata versus other pathways is relevant for quantifying the O3 influence on carbon and water cycles. We use a decade of O3, carbon, and energy eddy covariance (EC) fluxes at Harvard Forest to investigate interannual variability (IAV) in O3 deposition velocities (vd,O3). In each month, monthly mean vd,O3 for the highest year is twice that for the lowest. Two independent stomatal conductance estimates, based on either water vapor EC or gross primary productivity, vary little from year to year relative to canopy conductance. We conclude that nonstomatal deposition controls the substantial observed IAV in summertime vd,O3 during the 1990s over this deciduous forest. The absence of obvious relationships between meteorology and vd,O3 implies a need for additional long-term, high-quality measurements and further investigation of nonstomatal mechanisms.

6. Using an instrumental variable to test for unmeasured confounding.

PubMed

Guo, Zijian; Cheng, Jing; Lorch, Scott A; Small, Dylan S

2014-09-10

An important concern in an observational study is whether or not there is unmeasured confounding, that is, unmeasured ways in which the treatment and control groups differ before treatment, which affect the outcome. We develop a test of whether there is unmeasured confounding when an instrumental variable (IV) is available. An IV is a variable that is independent of the unmeasured confounding and encourages a subject to take one treatment level versus another, while having no effect on the outcome beyond its encouragement of a certain treatment level. We show what types of unmeasured confounding can be tested for with an IV and develop a test for this type of unmeasured confounding that has correct type I error rate. We show that the widely used Durbin-Wu-Hausman test can have inflated type I error rates when there is treatment effect heterogeneity. Additionally, we show that our test provides more insight into the nature of the unmeasured confounding than the Durbin-Wu-Hausman test. We apply our test to an observational study of the effect of a premature infant being delivered in a high-level neonatal intensive care unit (one with mechanical assisted ventilation and high volume) versus a lower level unit, using the excess travel time a mother lives from the nearest high-level unit to the nearest lower-level unit as an IV.

7. Young proteins experience more variable selection pressures than old proteins

PubMed Central

Vishnoi, Anchal; Kryazhimskiy, Sergey; Bazykin, Georgii A.; Hannenhalli, Sridhar; Plotkin, Joshua B.

2010-01-01

It is well known that young proteins tend to experience weaker purifying selection and evolve more quickly than old proteins. Here, we show that, in addition, young proteins tend to experience more variable selection pressures over time than old proteins. We demonstrate this pattern in three independent taxonomic groups: yeast, Drosophila, and mammals. The increased variability of selection pressures on young proteins is highly significant even after controlling for the fact that young proteins are typically shorter and experience weaker purifying selection than old proteins. The majority of our results are consistent with the hypothesis that the function of a young gene tends to change over time more readily than that of an old gene. At the same time, our results may be caused in part by young genes that serve constant functions over time, but nevertheless appear to evolve under changing selection pressures due to depletion of adaptive mutations. In either case, our results imply that the evolution of a protein-coding sequence is partly determined by its age and origin, and not only by the phenotypic properties of the encoded protein. We discuss, via specific examples, the consequences of these findings for understanding of the sources of evolutionary novelty. PMID:20921233

8. Political attitudes develop independently of personality traits.

PubMed

Hatemi, Peter K; Verhulst, Brad

2015-01-01

The primary assumption within the recent personality and political orientations literature is that personality traits cause people to develop political attitudes. In contrast, research relying on traditional psychological and developmental theories suggests the relationship between most personality dimensions and political orientations are either not significant or weak. Research from behavioral genetics suggests the covariance between personality and political preferences is not causal, but due to a common, latent genetic factor that mutually influences both. The contradictory assumptions and findings from these research streams have yet to be resolved. This is in part due to the reliance on cross-sectional data and the lack of longitudinal genetically informative data. Here, using two independent longitudinal genetically informative samples, we examine the joint development of personality traits and attitude dimensions to explore the underlying causal mechanisms that drive the relationship between these features and provide a first step in resolving the causal question. We find change in personality over a ten-year period does not predict change in political attitudes, which does not support a causal relationship between personality traits and political attitudes as is frequently assumed. Rather, political attitudes are often more stable than the key personality traits assumed to be predicting them. Finally, the results from our genetic models find that no additional variance is accounted for by the causal pathway from personality traits to political attitudes. Our findings remain consistent with the original construction of the five-factor model of personality and developmental theories on attitude formation, but challenge recent work in this area.

9. Political Attitudes Develop Independently of Personality Traits

PubMed Central

Hatemi, Peter K.; Verhulst, Brad

2015-01-01

The primary assumption within the recent personality and political orientations literature is that personality traits cause people to develop political attitudes. In contrast, research relying on traditional psychological and developmental theories suggests the relationship between most personality dimensions and political orientations are either not significant or weak. Research from behavioral genetics suggests the covariance between personality and political preferences is not causal, but due to a common, latent genetic factor that mutually influences both. The contradictory assumptions and findings from these research streams have yet to be resolved. This is in part due to the reliance on cross-sectional data and the lack of longitudinal genetically informative data. Here, using two independent longitudinal genetically informative samples, we examine the joint development of personality traits and attitude dimensions to explore the underlying causal mechanisms that drive the relationship between these features and provide a first step in resolving the causal question. We find change in personality over a ten-year period does not predict change in political attitudes, which does not support a causal relationship between personality traits and political attitudes as is frequently assumed. Rather, political attitudes are often more stable than the key personality traits assumed to be predicting them. Finally, the results from our genetic models find that no additional variance is accounted for by the causal pathway from personality traits to political attitudes. Our findings remain consistent with the original construction of the five-factor model of personality and developmental theories on attitude formation, but challenge recent work in this area. PMID:25734580

10. Melanoma biomolecules: independently identified but functionally intertwined.

PubMed

Dye, Danielle E; Medic, Sandra; Ziman, Mel; Coombe, Deirdre R

2013-09-24

The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (<1 mm thick) will have recurrence and die within 10 years, despite no evidence of local or metastatic spread at the time of diagnosis. Thus, there is a need for additional prognostic markers to help identify those patients that may be at risk of recurrent disease. Many studies and several meta-analyses have compared gene and protein expression in melanocytes, naevi, primary, and metastatic melanoma in an attempt to find informative prognostic markers for these patients. However, although a large number of putative biomarkers have been described, few of these molecules are informative when used in isolation. The best approach is likely to involve a combination of molecules. We believe one approach could be to analyze the expression of a group of interacting proteins that regulate different aspects of the metastatic pathway. This is because a primary lesion expressing proteins involved in multiple stages of metastasis may be more likely to lead to secondary disease than one that does not. This review focuses on five putative biomarkers - melanoma cell adhesion molecule (MCAM), galectin-3 (gal-3), matrix metalloproteinase 2 (MMP-2), chondroitin sulfate proteoglycan 4 (CSPG4), and paired box 3 (PAX3). The goal is to provide context around what is known about the contribution of these biomarkers to melanoma biology and metastasis. Although each of these molecules have been independently identified as likely biomarkers, it is clear from our analyses that each are closely linked with each other, with intertwined roles in melanoma biology.

11. Human skin: an independent peripheral endocrine organ.

PubMed

Zouboulis, C C

2000-01-01

The historical picture of the endocrine system as a set of discrete hormone-producing organs has been substituted by organs regarded as organized communities in which the cells emit, receive and coordinate molecular signals from established endocrine organs, other distant sources, their neighbors, and themselves. In this wide sense, the human skin and its tissues are targets as well as producers of hormones. Although the role of hormones in the development of human skin and its capacity to produce and release hormones are well established, little attention has been drawn to the ability of human skin to fulfil the requirements of a classic endocrine organ. Indeed, human skin cells produce insulin-like growth factors and -binding proteins, propiomelanocortin derivatives, catecholamines, steroid hormones and vitamin D from cholesterol, retinoids from diet carotenoids, and eicosanoids from fatty acids. Hormones exert their biological effects on the skin through interaction with high-affinity receptors, such as receptors for peptide hormones, neurotransmitters, steroid hormones and thyroid hormones. In addition, the human skin is able to metabolize hormones and to activate and inactivate them. These steps are overtaken in most cases by different skin cell populations in a coordinated way indicating the endocrine autonomy of the skin. Characteristic examples are the metabolic pathways of the corticotropin-releasing hormone/propiomelanocortin axis, steroidogenesis, vitamin D, and retinoids. Hormones exhibit a wide range of biological activities on the skin, with major effects caused by growth hormone/insulin-like growth factor-1, neuropeptides, sex steroids, glucocorticoids, retinoids, vitamin D, peroxisome proliferator-activated receptor ligands, and eicosanoids. At last, human skin produces hormones which are released in the circulation and are important for functions of the entire organism, such as sex hormones, especially in aged individuals, and insulin-like growth

12. A novel variable selection approach that iteratively optimizes variable space using weighted binary matrix sampling.

PubMed

Deng, Bai-chuan; Yun, Yong-huan; Liang, Yi-zeng; Yi, Lun-zhao

2014-10-07

In this study, a new optimization algorithm called the Variable Iterative Space Shrinkage Approach (VISSA) that is based on the idea of model population analysis (MPA) is proposed for variable selection. Unlike most of the existing optimization methods for variable selection, VISSA statistically evaluates the performance of variable space in each step of optimization. Weighted binary matrix sampling (WBMS) is proposed to generate sub-models that span the variable subspace. Two rules are highlighted during the optimization procedure. First, the variable space shrinks in each step. Second, the new variable space outperforms the previous one. The second rule, which is rarely satisfied in most of the existing methods, is the core of the VISSA strategy. Compared with some promising variable selection methods such as competitive adaptive reweighted sampling (CARS), Monte Carlo uninformative variable elimination (MCUVE) and iteratively retaining informative variables (IRIV), VISSA showed better prediction ability for the calibration of NIR data. In addition, VISSA is user-friendly; only a few insensitive parameters are needed, and the program terminates automatically without any additional conditions. The Matlab codes for implementing VISSA are freely available on the website: https://sourceforge.net/projects/multivariateanalysis/files/VISSA/.

PubMed

Simon, R A

1984-10-01

There is a long list of additives used by the pharmaceutical industry. Most of the agents used have not been implicated in hypersensitivity reactions. Among those that have, only reactions to parabens and sulfites have been well established. Parabens have been shown to be responsible for rare immunoglobulin E-mediated reactions that occur after the use of local anesthetics. Sulfites, which are present in many drugs, including agents commonly used to treat asthma, have been shown to provoke severe asthmatic attacks in sensitive individuals. Recent studies indicate that additives do not play a significant role in "hyperactivity." The role of additives in urticaria is not well established and therefore the incidence of adverse reactions in this patient population is simply not known. In double-blind, placebo-controlled studies, reactions to tartrazine or additives other than sulfites, if they occur at all, are indeed quite rare for the asthmatic population, even for the aspirin-sensitive subpopulation.

MedlinePlus

... SNIPEND SNIPSTART Find A Radiation Oncologist SNIPEND Additional Treatment Options SNIPSTART A A SNIPEND Chemotherapy Medicines prescribed ... such as antibodies, to fight cancer. Novel Targeted Therapies Cancer doctors now know much more about how ...

15. Calculators and Computers: Graphical Addition.

ERIC Educational Resources Information Center

Spero, Samuel W.

1978-01-01

A computer program is presented that generates problem sets involving sketching graphs of trigonometric functions using graphical addition. The students use calculators to sketch the graphs and a computer solution is used to check it. (MP)

16. Latent Variable Interaction Modeling.

ERIC Educational Resources Information Center

Schumacker, Randall E.

2002-01-01

Used simulation to study two different approaches to latent variable interaction modeling with continuous observed variables: (1) a LISREL 8.30 program and (2) data analysis through PRELIS2 and SIMPLIS programs. Results show that parameter estimation was similar but standard errors were different. Discusses differences in ease of implementation.…

17. A variety of variables.

PubMed

Jupiter, Daniel C

2014-01-01

In designing studies and developing plans for analyses, we must consider which tests are appropriate for the types of variables we are using. Here I describe the types of variables available to us, and I briefly consider the appropriate tools to use in their analysis.

18. Variable Density Tunnel

NASA Technical Reports Server (NTRS)

1931-01-01

Variable Density Tunnel in operation. Man at far right is probably Harold J. 'Cannonball' Tuner, longtime safety officer, who started with Curtiss in the teens. This view of the Variable Density Tunnel clearly shows the layout of the Tunnel's surroundings, as well as the plumbing and power needs of the this innovative research tool.

19. Variable volume combustor

DOEpatents

Ostebee, Heath Michael; Ziminsky, Willy Steve; Johnson, Thomas Edward; Keener, Christopher Paul

2017-01-17

The present application provides a variable volume combustor for use with a gas turbine engine. The variable volume combustor may include a liner, a number of micro-mixer fuel nozzles positioned within the liner, and a linear actuator so as to maneuver the micro-mixer fuel nozzles axially along the liner.

20. Reinforcing Saccadic Amplitude Variability

ERIC Educational Resources Information Center

Paeye, Celine; Madelain, Laurent

2011-01-01

Saccadic endpoint variability is often viewed as the outcome of neural noise occurring during sensorimotor processing. However, part of this variability might result from operant learning. We tested this hypothesis by reinforcing dispersions of saccadic amplitude distributions, while maintaining constant their medians. In a first experiment we…

1. Revisiting Gender in Open and Distance Learning--An Independent Variable or a Mediated Reality?

ERIC Educational Resources Information Center

Sen, Rekha Sharma; Samdup, Pema Eden

2009-01-01

The ideological moorings of distance education, both as a discipline and as a mode, rest on cognisance of multiple and varying contexts of learners, which it aims to address through responsive course content creation and delivery strategies. One of the frames through which the context needs to be understood is gender. There is research stating…

2. Combined prediction model of death toll for road traffic accidents based on independent and dependent variables.

PubMed

Feng, Zhong-xiang; Lu, Shi-sheng; Zhang, Wei-hua; Zhang, Nan-nan

2014-01-01

In order to build a combined model which can meet the variation rule of death toll data for road traffic accidents and can reflect the influence of multiple factors on traffic accidents and improve prediction accuracy for accidents, the Verhulst model was built based on the number of death tolls for road traffic accidents in China from 2002 to 2011; and car ownership, population, GDP, highway freight volume, highway passenger transportation volume, and highway mileage were chosen as the factors to build the death toll multivariate linear regression model. Then the two models were combined to be a combined prediction model which has weight coefficient. Shapley value method was applied to calculate the weight coefficient by assessing contributions. Finally, the combined model was used to recalculate the number of death tolls from 2002 to 2011, and the combined model was compared with the Verhulst and multivariate linear regression models. The results showed that the new model could not only characterize the death toll data characteristics but also quantify the degree of influence to the death toll by each influencing factor and had high accuracy as well as strong practicability.

3. Using Cost as an Independent Variable (CAIV) to Reduce Total Ownership Cost

DTIC Science & Technology

2006-01-31

CAIV pilot programs in each of the DoD Components that might yield valuable lessons- learned for the acquisition community. Without designated CAIV...Costs,” that comprises a collection of the lessons- learned and best practices garnered from the R-TOC Pilot programs.7 Expert Interviews Published...each of the DoD Components that might yield valuable lessons- learned for the acquisition community. However, for unknown reasons, none has been

4. Improving Students' Understanding of, and Ability to Identify Independent and Dependent Variables

ERIC Educational Resources Information Center

Aldrich, Rosalie S.

2015-01-01

Students need to have a basic understanding of research methods before obtaining a communication degree in order to become an intelligent consumer of research--someone who is able to read, understand, explain, and critically evaluate communication and other research reported in scholarly journals as well as in the popular press. These skills are…

5. On Neglect of the Independent Variable in Program Evaluation. Project MITT Occasional Paper.

ERIC Educational Resources Information Center

Charters, W. W., Jr.; Jones, John E.

This paper illustrates the need for full description and measurement of differences between "experimental" and "control" situations in school program evaluation studies. Two studies were completed at the University of Oregon involving the innovative program--differentiated staffing (DS). The first study, a doctoral investigation, sought to assess…

6. Sexuality as an Independent Variable: The Contribution to (or Protection against) Chronic Disease,

DTIC Science & Technology

1978-01-05

science has come to indict a long list of risk factors in disabling and fatal diseases: dietary intake, physical exercise activities , food chain pollutants...a plausible notion that sexual activity contributes to health outcome in a manner beyond merely serving as a mode for transmission of infectious...array the distribution of sexual activity against the distribution of health outcome is suggested.-. C-7, A3 Ś" . ... i p.1 The purpose of this

7. A Scale-Independent Clustering Method with Automatic Variable Selection Based on Trees

DTIC Science & Technology

2014-03-01

3 Figure 3. Tree with deviance in large circles and leaf number in small circles (from Buttrey, 2006...to thank my cohort and fellow Operations Research students for getting me through this program. RJ, Trish, Alok, Brennan, Hamadi, Cyrus, Dave, and...between observations, and as described by Faraway (2006) trees are unaffected by linear transformations. Since we scale the resulting deviances anyway

8. Methods for Calculating the Probability Distribution of Sums of Independent Random Variables

DTIC Science & Technology

1986-07-01

CANNON ARTY WPNS,DOVER NJ 07801-5001 ATTN: AMCPM-CAWS COMMANDER, US ARMY LOGISTICS CENTER FORT LEE, VA 23801 ATTN: ATCL-S 20 i» *. • 3rv rv»n...frM^^ M & ROUTINE FOR MAT.INVERSE (N, AM) 1 I "ROUTINE TO OBTAIN THE INVERSE 0? THE N BY M MATRIX AM VIA THE ••COMPACT FORM OF THE GAUSS -JORDAN

9. Food additives and preschool children.

PubMed

Martyn, Danika M; McNulty, Breige A; Nugent, Anne P; Gibney, Michael J

2013-02-01

Food additives have been used throughout history to perform specific functions in foods. A comprehensive framework of legislation is in place within Europe to control the use of additives in the food supply and ensure they pose no risk to human health. Further to this, exposure assessments are regularly carried out to monitor population intakes and verify that intakes are not above acceptable levels (acceptable daily intakes). Young children may have a higher dietary exposure to chemicals than adults due to a combination of rapid growth rates and distinct food intake patterns. For this reason, exposure assessments are particularly important in this age group. The paper will review the use of additives and exposure assessment methods and examine factors that affect dietary exposure by young children. One of the most widely investigated unfavourable health effects associated with food additive intake in preschool-aged children are suggested adverse behavioural effects. Research that has examined this relationship has reported a variety of responses, with many noting an increase in hyperactivity as reported by parents but not when assessed using objective examiners. This review has examined the experimental approaches used in such studies and suggests that efforts are needed to standardise objective methods of measuring behaviour in preschool children. Further to this, a more holistic approach to examining food additive intakes by preschool children is advisable, where overall exposure is considered rather than focusing solely on behavioural effects and possibly examining intakes of food additives other than food colours.

10. Basic properties and variability

NASA Technical Reports Server (NTRS)

Querci, Francois R.

1987-01-01

Giant and supergiant M, S, and C stars are discussed in this survey of research. Basic properties as determined by spectra, chemical composition, photometry, or variability type are discussed. Space motions and space distributions of cool giants are described. Distribution of these stars in our galaxy and those nearby is discussed. Mira variables in particular are surveyed with emphasis on the following topics: (1) phase lag phenomenon; (2) Mira light curves; (3) variations in color indices; (4) determination of multiple periods; (5) correlations between quantities such as period length, light-curve shape, infrared (IR) excess, and visible and IR color diagram; (6) semiregular (SR) variables and different time scales in SR light variations; (7) irregular variable Lb and Lc stars; (8) different time-scale light variations; (9) hydrogen-deficient carbon (HdC) stars, in particular RCB stars; and (10) irreversible changes and rapid evolution in red variable stars.

11. Independent association of glucocorticoids with damage accrual in SLE

PubMed Central

Apostolopoulos, Diane; Kandane-Rathnayake, Rangi; Raghunath, Sudha; Hoi, Alberta; Nikpour, Mandana; Morand, Eric F

2016-01-01

Objectives To determine factors associated with damage accrual in a prospective cohort of patients with SLE. Methods Patients with SLE who attended the Lupus Clinic at Monash Health, Australia, between 2007 and 2013 were studied. Clinical variables included disease activity (Systemic Lupus Erythematosus Disease Activity Index-2K, SLEDAI-2K), time-adjusted mean SLEDAI, cumulative glucocorticoid dose and organ damage (Systemic Lupus International Collaborating Clinics Damage Index (SDI)). Multivariate logistic regression analyses were performed to identify factors associated with damage accrual. Results A total of 162 patients were observed over a median (IQR) 3.6 (2.0–4.7) years. Seventy-five per cent (n=121) of patients received glucocorticoids. Damage accrual was significantly more frequent in glucocorticoid-exposed patients (42% vs 15%, p<0.01). Higher glucocorticoid exposure was independently associated with overall damage accrual after controlling for factors including ethnicity and disease activity and was significant at time-adjusted mean doses above 4.42 mg prednisolone/day; the OR of damage accrual in patients in the highest quartile of cumulative glucocorticoid exposure was over 10. Glucocorticoid exposure was independently associated with damage accrual in glucocorticoid-related and non-glucocorticoid related domains of the SDI. Conclusions Glucocorticoid use is independently associated with the accrual of damage in SLE, including in non-glucocorticoid related domains. PMID:27933196

12. Evaluation of certain food additives.

PubMed

2015-01-01

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, and to prepare specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of and assessment of dietary exposure to food additives, including flavouring agents. A summary follows of the Committee's evaluations of technical, toxicological and dietary exposure data for eight food additives (Benzoe tonkinensis; carrageenan; citric and fatty acid esters of glycerol; gardenia yellow; lutein esters from Tagetes erecta; octenyl succinic acid-modified gum arabic; octenyl succinic acid-modified starch; paprika extract; and pectin) and eight groups of flavouring agents (aliphatic and alicyclic hydrocarbons; aliphatic and aromatic ethers; ionones and structurally related substances; miscellaneous nitrogen-containing substances; monocyclic and bicyclic secondary alcohols, ketones and related esters; phenol and phenol derivatives; phenyl-substituted aliphatic alcohols and related aldehydes and esters; and sulfur-containing heterocyclic compounds). Specifications for the following food additives were revised: citric acid; gellan gum; polyoxyethylene (20) sorbitan monostearate; potassium aluminium silicate; and Quillaia extract (Type 2). Annexed to the report are tables summarizing the Committee's recommendations for dietary exposures to and toxicological evaluations of all of the food additives and flavouring agents considered at this meeting.

13. [INVITED] Lasers in additive manufacturing

NASA Astrophysics Data System (ADS)

Pinkerton, Andrew J.

2016-04-01

Additive manufacturing is a topic of considerable ongoing interest, with forecasts predicting it to have major impact on industry in the future. This paper focusses on the current status and potential future development of the technology, with particular reference to the role of lasers within it. It begins by making clear the types and roles of lasers in the different categories of additive manufacturing. This is followed by concise reviews of the economic benefits and disadvantages of the technology, current state of the market and use of additive manufacturing in different industries. Details of these fields are referenced rather than expanded in detail. The paper continues, focusing on current indicators to the future of additive manufacturing. Barriers to its development, trends and opportunities in major industrial sectors, and wider opportunities for its development are covered. Evidence indicates that additive manufacturing may not become the dominant manufacturing technology in all industries, but represents an excellent opportunity for lasers to increase their influence in manufacturing as a whole.

14. Telomerase recruitment requires both TCAB1 and Cajal bodies independently.

PubMed

Stern, J Lewis; Zyner, Katherine G; Pickett, Hilda A; Cohen, Scott B; Bryan, Tracy M

2012-07-01

The ability of most cancer cells to grow indefinitely relies on the enzyme telomerase and its recruitment to telomeres. In human cells, recruitment depends on the Cajal body RNA chaperone TCAB1 binding to the RNA subunit of telomerase (hTR) and is also thought to rely on an N-terminal domain of the catalytic subunit, hTERT. We demonstrate that coilin, an essential structural component of Cajal bodies, is required for endogenous telomerase recruitment to telomeres but that overexpression of telomerase can compensate for Cajal body absence. In contrast, recruitment of telomerase was sensitive to levels of TCAB1, and this was not rescued by overexpression of telomerase. Thus, although Cajal bodies are important for recruitment, TCAB1 has an additional role in this process that is independent of these structures. TCAB1 itself localizes to telomeres in a telomerase-dependent but Cajal body-independent manner. We identify a point mutation in hTERT that largely abolishes recruitment yet does not affect association of telomerase with TCAB1, suggesting that this region mediates recruitment by an independent mechanism. Our results demonstrate that telomerase has multiple independent requirements for recruitment to telomeres and that the function of TCAB1 is to directly transport telomerase to telomeres.

15. CdiA promotes receptor-independent intercellular adhesion.

PubMed

Ruhe, Zachary C; Townsley, Loni; Wallace, Adam B; King, Andrew; Van der Woude, Marjan W; Low, David A; Yildiz, Fitnat H; Hayes, Christopher S

2015-10-01

CdiB/CdiA proteins mediate inter-bacterial competition in a process termed contact-dependent growth inhibition (CDI). Filamentous CdiA exoproteins extend from CDI(+) cells and bind specific receptors to deliver toxins into susceptible target bacteria. CDI has also been implicated in auto-aggregation and biofilm formation in several species, but the contribution of CdiA-receptor interactions to these multi-cellular behaviors has not been examined. Using Escherichia coli isolate EC93 as a model, we show that cdiA and bamA receptor mutants are defective in biofilm formation, suggesting a prominent role for CdiA-BamA mediated cell-cell adhesion. However, CdiA also promotes auto-aggregation in a BamA-independent manner, indicating that the exoprotein possesses an additional adhesin activity. Cells must express CdiA in order to participate in BamA-independent aggregates, suggesting that adhesion could be mediated by homotypic CdiA-CdiA interactions. The BamA-dependent and BamA-independent interaction domains map to distinct regions within the CdiA filament. Thus, CdiA orchestrates a collective behavior that is independent of its growth-inhibition activity. This adhesion should enable 'greenbeard' discrimination, in which genetically unrelated individuals cooperate with one another based on a single shared trait. This kind-selective social behavior could provide immediate fitness benefits to bacteria that acquire the systems through horizontal gene transfer.

16. Design of Discrete Variable Structure Controller Based on Variable Boundary Layer

NASA Astrophysics Data System (ADS)

Su, Shibin; Wang, Heng; Zhang, Hua; Xiong, Wei

Variable structure control is recognized as the most efficient method for control of uncertain systems. In order to reduce the chattering and improve the stability of the Discrete-time Variable Structure Control System (DVSCS) with parameter uncertainties and external disturbances, this paper proposes a variable structure controller based on variable boundary layer. Simulations results demonstrate the controller is not only effectively reduce chattering of the DVSCS, but improve the asymptotic stability and robustness of system. In addition, the results also revealed that the controller has strong effectiveness and robustness of the trajectory tracking.

17. Additive manufacturing of hybrid circuits

SciTech Connect

Bell, Nelson S.; Sarobol, Pylin; Cook, Adam; Clem, Paul G.; Keicher, David M.; Hirschfeld, Deidre; Hall, Aaron Christopher

2016-03-26

There is a rising interest in developing functional electronics using additively manufactured components. Considerations in materials selection and pathways to forming hybrid circuits and devices must demonstrate useful electronic function; must enable integration; and must complement the complex shape, low cost, high volume, and high functionality of structural but generally electronically passive additively manufactured components. This article reviews several emerging technologies being used in industry and research/development to provide integration advantages of fabricating multilayer hybrid circuits or devices. First, we review a maskless, noncontact, direct write (DW) technology that excels in the deposition of metallic colloid inks for electrical interconnects. Second, we review a complementary technology, aerosol deposition (AD), which excels in the deposition of metallic and ceramic powder as consolidated, thick conformal coatings and is additionally patternable through masking. As a result, we show examples of hybrid circuits/devices integrated beyond 2-D planes, using combinations of DW or AD processes and conventional, established processes.

18. Trends and variability of East African rainfall and its relationship to the Mascarene High pressure system

NASA Astrophysics Data System (ADS)

Seregina, Larisa; Pinto, Joaquim G.; Fink, Andreas H.; Ermert, Volker

2016-04-01

In the recent decades, East Africa needs to deal with strong fluctuations in seasonal rainfall including precipitation extremes. In context of climate change, such extremes can become more frequent in the future. However, regional climate projections are uncertain about the future development of seasonal precipitation in the region. Rainfall regimes over East Africa are influenced by multiple factors, including two monsoon systems, several convergence zones and the Rift Valley lakes. In addition, local conditions, like topography, modulate the large-scale rainfall pattern. East African rainfall variability is also influenced by various teleconnections like the Indian Ocean Zonal Mode and El Niño Southern Oscillation. The study of past climate variability in East Africa requires sufficient observational data coverage in the region. As East Africa does not have a dense observational network of meteorological stations, satellite rainfall observations gain on importance in studies on climate variability in the region. The specific aim of the present study is the analysis of historic data from weather stations in East Africa (Kenya, Tanzania, Ruanda and Uganda), the use of gridded satellite products, and three-dimensional atmospheric reanalysis (e.g., ERA-Interim) to quantify climate variability in the recent past and to understand its causes. Climate variability and trends, including changes in extreme events, are evaluated using ETCCDI climate change and standardized precipitation indices. These climate indices are determined in order to investigate the variability of rainfall and its trends with the focus on recent decades. For seasonal trend analysis, an independent and non-calendaric rainfall onset criterion is introduced. In the follow-up, statistical and dynamical analyses are conducted to quantify the local impact of Mascarene High as a part of the Subtropical High Pressure Ridge on East African seasonal rainfall. Possible connections to pertinent large

19. Magnetically Controlled Variable Transformer

NASA Technical Reports Server (NTRS)

Kleiner, Charles T.

1994-01-01

Improved variable-transformer circuit, output voltage and current of which controlled by use of relatively small current supplied at relatively low power to control windings on its magnetic cores. Transformer circuits of this type called "magnetic amplifiers" because ratio between controlled output power and power driving control current of such circuit large. This ratio - power gain - can be as large as 100 in present circuit. Variable-transformer circuit offers advantages of efficiency, safety, and controllability over some prior variable-transformer circuits.

20. Variability study for saltstone

SciTech Connect

Harbour, J. R.; Edwards, T. B.; Hansen, E. K.; Williams, V. J.

2005-10-01

This report is a summary of the bench-scale experimental studies performed by the Savannah River National Laboratory (SRNL) for Waste Solidification Engineering (WSE) to establish the viability of a grout-based variability study. In order for a variability study to be useful, the property measurements of the fresh and cured Saltstone must be reproducible with an inherent variation that is small compared to the changes in the properties measured over the expected range of variability for a Salt Batch. This scoping task addressed the issue of reproducibility for Saltstone.

1. Materialism, status consumption, and consumer independence.

PubMed

Goldsmith, Ronald Earl; Clark, Ronald A

2012-01-01

Materialism influences many people. We focus on two aspects of this influence: reactions to prestige products and to the influence of others. A study of 187 U.S. student consumers shows that materialism is positively related to buying products that confer status. In contrast, materialism is negatively related to consumer independence, an enduring tendency to pay minimal attention to the prescribed norms of other consumers and to make product and brand decisions according to personal preferences. Consuming products for status is also negatively related to consumer independence. Moreover, the association between materialism and consumer independence is completely mediated by consuming for status. Materialism urges consumers to be status conscious so that they follow social norms in purchasing, but seeking status through goods is avoided by less materialistic, independent consumers. A second study (n = 258) also using student consumers confirmed these results.

2. Prompting Sequences in Teaching Independent Living Skills.

ERIC Educational Resources Information Center

Walls, Richard T.; And Others

1981-01-01

The effects of three prompting sequences on the acquisition of independent living skills with 14 mild and moderately mentally retarded vocational rehabilitation clients (16 to 50 years old) are examined. (Author)

3. Evidence for an Independent Syndrome of Hyperactivity.

ERIC Educational Resources Information Center

Trites, R. L.; Laprade, K.

1983-01-01

Results of a factor analysis of the Conners Teacher Rating Scales for over 9,000 children provided preliminary evidence that hyperactivity and an aggressive conduct disorder can exist independently in children. (RH)

4. Geometry independence of three-string vertices

NASA Astrophysics Data System (ADS)

Maeno, Masahiro

1989-01-01

The geometry independence of three-string vertices in both HIKKO's and Witten's string field theories is examined. A careful regularization shows that the anomaly which has been reported by Morris and Mañes vanishes.

5. The Isle of Independent Study: A Parable.

ERIC Educational Resources Information Center

Wiley, Cathy; Norberg, Carol M.

1982-01-01

The author mentions Project THINK (Tapping Heuristic Intelligence for New Knowledge) and describes the Isle of Independent Study, a seven-step procedure designed in the form of a map for use with upper elementary gifted students. (SB)

6. Energy Independence and Security Act of 2007

EPA Pesticide Factsheets

This page provides an overview of the Energy Independence and Security Act (EISA) of 2007, which aims to increase U.S. energy security, develop renewable energy production, and improve vehicle fuel economy.

7. Natural Products: An Independent Study Project

ERIC Educational Resources Information Center

Griffin, Roger W., Jr.

1974-01-01

Described is an independent study project for students in chemistry at New College, Sarasota, Florida. Six students collected and analyzed local plants to determine content of alkaloids, terpenes, and flavonoids. (RH)

8. Residential independence of elderly immigrants in Canada.

PubMed

Lee, Sharon M; Edmonston, Barry

2014-12-01

This article addresses three questions: Are elderly immigrants less likely than Canadian-born elderly people to reside independently? What are the effects of economic, cultural, and life course factors on residential independence among elderly immigrants? What are the effects of immigrant-specific characteristics such as duration of residence and cultural background? Descriptive results show that elderly immigrants are less likely to reside independently, but the large gap of over 15 per cent is reduced to 5 per cent once economic, cultural, life course, and other factors are considered in the multivariate analysis. Effects of economic, cultural, and life course factors are mostly as expected, as are those of immigrant-specific characteristics such as duration of residence. Although aging immigrants have more-varied living arrangements than their Canadian-born peers, these are likely to increasingly include residential independence.

9. List of Independent Commercial Importers (ICIs)

EPA Pesticide Factsheets

This document is a list of Independent Commercial Importers (ICIs) who currently hold a valid certificate of conformity from EPA allowing importation of certain nonconforming vehicles into the United States. (EPA publication # EPA-420-F-13-036)

10. Energy Independent Agri-Business Outreach

SciTech Connect

Niday, Karen

2011-01-30

Establish and showcase energy independence at a small to medium scale farm by installing renewable energy equipment that will enable an agribusiness to survive using only energy that is generated onsite

11. Tougher Addition Polyimides Containing Siloxane

NASA Technical Reports Server (NTRS)

St. Clair, T. L.; Maudgal, S.

1986-01-01

Laminates show increased impact resistances and other desirable mechanical properties. Bismaleamic acid extended by reaction of diaminosiloxane with maleic anhydride in 1:1 molar ratio, followed by reaction with half this molar ratio of aromatic dianhydride. Bismaleamic acid also extended by reaction of diaminosiloxane with maleic anhydride in 1:2 molar ratio, followed by reaction with half this molar ratio of aromatic diamine (Michael-addition reaction). Impact resistances improved over those of unmodified bismaleimide, showing significant increase in toughness. Aromatic addition polyimides developed as both matrix and adhesive resins for applications on future aircraft and spacecraft.

12. Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database

PubMed Central

Li, Mu; Dai, Chen-Yang; Wang, Yu-Ning; Chen, Tao; Wang, Long; Yang, Ping; Xie, Dong; Mao, Rui; Chen, Chang

2016-01-01

Background Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64–0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54–0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53–0.93, p = 0.015). Methods We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors. PMID:27780931

13. Microstructural Control of Additively Manufactured Metallic Materials

NASA Astrophysics Data System (ADS)

Collins, P. C.; Brice, D. A.; Samimi, P.; Ghamarian, I.; Fraser, H. L.

2016-07-01

In additively manufactured (AM) metallic materials, the fundamental interrelationships that exist between composition, processing, and microstructure govern these materials’ properties and potential improvements or reductions in performance. For example, by using AM, it is possible to achieve highly desirable microstructural features (e.g., highly refined precipitates) that could not otherwise be achieved by using conventional approaches. Simultaneously, opportunities exist to manage macro-level microstructural characteristics such as residual stress, porosity, and texture, the last of which might be desirable. To predictably realize optimal microstructures, it is necessary to establish a framework that integrates processing variables, alloy composition, and the resulting microstructure. Although such a framework is largely lacking for AM metallic materials, the basic scientific components of the framework exist in literature. This review considers these key components and presents them in a manner that highlights key interdependencies that would form an integrated framework to engineer microstructures using AM.

14. Superresolving multiphoton interferences with independent light sources.

PubMed

Oppel, S; Büttner, T; Kok, P; von Zanthier, J

2012-12-07

We propose to use multiphoton interferences from statistically independent light sources in combination with linear optical detection techniques to enhance the resolution in imaging. Experimental results with up to five independent thermal light sources confirm this approach to improve the spatial resolution. Since no involved quantum state preparation or detection is required, the experiment can be considered an extension of the Hanbury Brown-Twiss experiment for spatial intensity correlations of order N>2.

15. Independence Day for IgA.

PubMed

Macpherson, Andrew J; McCoy, Kathy D

2015-09-15

IgA is induced through T-cell-dependent and -independent pathways. In this issue, Bunker et al. (2015) now show that the T-cell-independent pathway is sufficient to coat most small intestinal microbes specifically, and Fransen et al. (2015) find that IgA coating promotes uptake of microbes into Peyer's patches and drives further induction in a positive-feedback loop.

16. Variability Measures of Positive Random Variables

PubMed Central

Kostal, Lubomir; Lansky, Petr; Pokora, Ondrej

2011-01-01

During the stationary part of neuronal spiking response, the stimulus can be encoded in the firing rate, but also in the statistical structure of the interspike intervals. We propose and discuss two information-based measures of statistical dispersion of the interspike interval distribution, the entropy-based dispersion and Fisher information-based dispersion. The measures are compared with the frequently used concept of standard deviation. It is shown, that standard deviation is not well suited to quantify some aspects of dispersion that are often expected intuitively, such as the degree of randomness. The proposed dispersion measures are not entirely independent, although each describes the interspike intervals from a different point of view. The new methods are applied to common models of neuronal firing and to both simulated and experimental data. PMID:21799762

17. Kolmogorov’s and Mourier’s Strong Laws for Arrays with Independent and Identically Distributed Columns

DTIC Science & Technology

1984-02-01

Variables, translated by K.L. Chung, Addison-Wesley, Mass. 3. Mourier, E. (1953). "Elements aleatoire dans un espace de Banach," Annals Institut de Henri ... Poincare * 13, p. 159-244. 4. Petrov, V.V. (1975). Sumns of Independent Random Variables, translated by A.A. Brown Springer-Verlag, New York. 5

18. The Additive Property of Energy.

ERIC Educational Resources Information Center

Tsaoussis, Dimitris S.

1995-01-01

Presents exercises that analyze the additive property of energy. Concludes that if a body has more than one component of energy depending on the same physical quantity, the body's total energy will be the algebraic sum of the components if a linear relationship exists between the energy components and that physical quantity. (JRH)

19. Tetrasulfide extreme pressure lubricant additives

SciTech Connect

Gast, L.E.; Kenney, H.E.; Schwab, A.W.

1980-08-19

A novel class of compounds has been prepared comprising the tetrasulfides of /sup 18/C hydrocarbons, /sup 18/C fatty acids, and /sup 18/C fatty and alkyl and triglyceride esters. These tetrasulfides are useful as extreme pressure lubricant additives and show potential as replacements for sulfurized sperm whale oil.

20. Out of bounds additive manufacturing

SciTech Connect

Holshouser, Chris; Newell, Clint; Palas, Sid; Love, Lonnie J.; Kunc, Vlastimil; Lind, Randall F.; Lloyd, Peter D.; Rowe, John C.; Blue, Craig A.; Duty, Chad E.; Peter, William H.; Dehoff, Ryan R.

2013-03-01

Lockheed Martin and Oak Ridge National Laboratory are working on an additive manufacturing system capable of manufacturing components measured not in terms of inches or feet, but multiple yards in all dimensions with the potential to manufacture parts that are completely unbounded in size.

1. Solar variability datalogger

DOE PAGES

Lave, Matthew; Stein, Joshua; Smith, Ryan

2016-07-28

To address the lack of knowledge of local solar variability, we have developed and deployed a low-cost solar variability datalogger (SVD). While most currently used solar irradiance sensors are expensive pyranometers with high accuracy (relevant for annual energy estimates), low-cost sensors display similar precision (relevant for solar variability) as high-cost pyranometers, even if they are not as accurate. In this work, we present evaluation of various low-cost irradiance sensor types, describe the SVD, and present validation and comparison of the SVD collected data. In conclusion, the low cost and ease of use of the SVD will enable a greater understandingmore » of local solar variability, which will reduce developer and utility uncertainty about the impact of solar photovoltaic (PV) installations and thus will encourage greater penetrations of solar energy.« less

2. Solar variability datalogger

SciTech Connect

Lave, Matthew; Stein, Joshua; Smith, Ryan

2016-07-28

To address the lack of knowledge of local solar variability, we have developed and deployed a low-cost solar variability datalogger (SVD). While most currently used solar irradiance sensors are expensive pyranometers with high accuracy (relevant for annual energy estimates), low-cost sensors display similar precision (relevant for solar variability) as high-cost pyranometers, even if they are not as accurate. In this work, we present evaluation of various low-cost irradiance sensor types, describe the SVD, and present validation and comparison of the SVD collected data. In conclusion, the low cost and ease of use of the SVD will enable a greater understanding of local solar variability, which will reduce developer and utility uncertainty about the impact of solar photovoltaic (PV) installations and thus will encourage greater penetrations of solar energy.

3. Understanding Biomass Feedstock Variability

SciTech Connect

Kevin L. Kenney; William A. Smith; Garold L. Gresham; Tyler L. Westover

2013-01-01

If the singular goal of biomass logistics and the design of biomass feedstock supply systems is to reduce the per ton supply cost of biomass, these systems may very well develop with ultimate unintended consequences of highly variable and reduced quality biomass feedstocks. This paper demonstrates that due to inherent species variabilities, production conditions, and differing harvest, collection, and storage practices, this is a very real scenario that biomass producers and suppliers as well as conversion developers should be aware of. Biomass feedstock attributes of ash, carbohydrates, moisture, and particle morphology will be discussed. We will also discuss specifications for these attributes, inherent variability of these attributes in biomass feedstocks, and approaches and solutions for reducing variability for improving feedstock quality.

4. Discovery of variable stars

NASA Technical Reports Server (NTRS)

Kurochkin, N. Y.

1973-01-01

Instrumented methods of discovering variable stars are reviewed, specifically the blink comparator, color contrast method, positive-negative method, and television method. Among the empirical methods discussed, the Van Gent method is the most important.

5. Understanding Biomass Feedstock Variability

SciTech Connect

Kevin L. Kenney; Garold L. Gresham; William A. Smith; Tyler L. Westover

2013-01-01

If the singular goal of biomass logistics and the design of biomass feedstock supply systems is to reduce the per-ton supply cost of biomass, these systems may very well develop with ultimate unintended consequences of highly variable and reduced quality biomass feedstocks. This paper demonstrates that, due to inherent species variabilities, production conditions and differing harvest, collection and storage practices, this is a very real scenario that biomass producers and suppliers as well as conversion developers should be aware of. Biomass feedstock attributes of ash, carbohydrates, moisture and particle morphology will be discussed. We will also discuss specifications for these attributes, inherent variability of these attributes in biomass feedstocks, and approaches and solutions for reducing variability for improving feedstock quality.

6. Variable pitch propeller

NASA Technical Reports Server (NTRS)

Pistolesi, Enrico

1923-01-01

The advantages of variable pitch propellers over constant pitch propellers is presented along with different methods of varying the pitch. The technique of varying the shape of the propeller is presented as the most efficient one.

7. Variable frequency drive applications guide

SciTech Connect

Laloudakis, D.J.

1991-10-01

Traditionally, fans and pumps have been designed to be capable of handling the maximum demand of the system in which they are installed. However, quite often the actual demand can vary and it can be much lower than the original design capacity. These situations have been corrected in the past through additions of outlet dampers to fans or throttling valves to pumps. While these can be effective and simple controls they severely affect the efficiency of the system. Variable frequency (speed) is the most efficient means of capacity control. The most cost effective method of achieving variable speed capacity control is using AC adjustable frequency drives. AC adjustable frequency controls convert any fixed speed AC motor into an adjustable speed device. Adjusting the speed of a motor, by controlling the frequency of the AC power to that motor, reduces its horsepower requirements. According to pump and fan laws, capacity is proportional to speed while horsepower is proportional to the cube of the speed. Therefore, by reducing the speed of an AC motor by 20 percent the horsepower requirement is reduced by nearly 50 percent. Reduced speed through variable frequency control allows for flexibility of meeting changing weather and comfort requirements without operating costly equipment at full capacity.

8. Evaluation of certain food additives.

PubMed

2012-01-01

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, with a view to concluding as to safety concerns and to preparing specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of and assessment of dietary exposure to food additives, including flavouring agents. A summary follows of the Committee's evaluations of technical, toxicological and dietary exposure data for five food additives (magnesium dihydrogen diphosphate; mineral oil (medium and low viscosity) classes II and III; 3-phytase from Aspergillus niger expressed in Aspergillus niger; serine protease (chymotrypsin) from Nocardiopsis prasina expressed in Bacillus licheniformis; and serine protease (trypsin) from Fusarium oxysporum expressed in Fusarium venenatum) and 16 groups of flavouring agents (aliphatic and aromatic amines and amides; aliphatic and aromatic ethers; aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers containing furan substitution; aliphatic linear alpha,beta-unsaturated aldehydes, acids and related alcohols, acetals and esters; amino acids and related substances; epoxides; furfuryl alcohol and related substances; linear and branched-chain aliphatic, unsaturated, unconjugated alcohols, aldehydes, acids and related esters; miscellaneous nitrogen-containing substances; phenol and phenol derivatives; pyrazine derivatives; pyridine, pyrrole and quinoline derivatives; saturated aliphatic acyclic branched-chain primary alcohols, aldehydes and acids; simple aliphatic and aromatic sulfides and thiols; sulfur-containing heterocyclic compounds; and sulfur-substituted furan derivatives). Specifications for the following food additives were revised: ethyl cellulose, mineral oil (medium viscosity), modified starches and titanium

9. Variable contour securing system

NASA Technical Reports Server (NTRS)

Zebus, P. P.; Packer, P. N.; Haynie, C. C. (Inventor)

1978-01-01

A variable contour securing system has a retaining structure for a member whose surface contains a variable contour. The retaining mechanism includes a spaced array of adjustable spindles mounted on a housing. Each spindle has a base member support cup at one end. A vacuum source is applied to the cups for seating the member adjacent to the cups. A locking mechanism sets the spindles in a predetermined position once the member has been secured to the spindle support cups.

10. VARIABLE-THROW CAM

DOEpatents

Godsil, E.C.; Robinson, E.Y.

1963-07-16

A variable-throw cam comprising inner and outer eccentric sleeves which are adjustably locked together is described. The cam throw is varied by unlocking the inner and outer sleeves, rotating the outer sleeve relative to the inner one until the desired throw is obtained, and locking the sleeves together again. The cam is useful in applications wherein a continuously-variable throw is required, e.g., ram-and-die pressing operations, cyclic fatigue testing of materials, etc. (AEC)

11. Transient design of landfill liquid addition systems.

PubMed

Jain, Pradeep; Townsend, Timothy G; Tolaymat, Thabet M

2014-09-01

12. Independent Orbiter Assessment (IOA): Assessment of the crew equipment subsystem

NASA Technical Reports Server (NTRS)

Saxon, H.; Richard, Bill; Sinclair, S. K.

1988-01-01

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA effort first completed an analysis of the Crew Equipment hardware, generating draft failure modes and potential critical items. To preserve independence, this analysis was accomplished without reliance upon the results contained within the NASA FMEA/CIL documentation. The IOA results were then compared to the NASA FMEA/CIL baseline with proposed Post 51-L updates included. A resolution of each discrepancy from the comparison is provided through additional analysis as required. This report documents the results of that comparison for the Orbiter Crew Equipment hardware. The IOA product for the Crew Equipment analysis consisted of 352 failure mode worksheets that resulted in 78 potential critical items being identified. Comparison was made to the NASA baseline which consisted of 351 FMEAs and 82 CIL items.

13. Abdominal aortic aneurysm-an independent disease to atherosclerosis?

PubMed

Toghill, Bradley J; Saratzis, Athanasios; Bown, Matthew J

Atherosclerosis and abdominal aortic aneurysms (AAAs) are multifactorial and polygenic diseases with known environmental and genetic risk factors that contribute toward disease development. Atherosclerosis represents an important independent risk factor for AAA, as people with AAA often have atherosclerosis. Studies have shown that comorbidity is usually between ~25% and 55%, but it is still not fully known whether this association is causal or a result of common shared risk profiles. Most recent epidemiological, clinical, and biological evidence suggests that the two pathologies are more distinct than traditionally thought. For instance diabetes mellitus, hypercholesterolemia, and obesity are high risk for atherosclerosis development but are not as pronounced in AAA, whereas smoking, gender, and ethnicity are particularly high risk for AAA but less so for atherosclerosis. In addition, genetic and epigenetic studies have identified independent risk loci involved in AAA susceptibility that are not associated with other cardiovascular diseases, and research on important common cardiovascular biomarkers has illustrated discrepancies in those with AAA.

14. Polarization-independent transparency window induced by complementary graphene metasurfaces

NASA Astrophysics Data System (ADS)

Lu, Wei Bing; Liu, Ji Long; Zhang, Jin; Wang, Jian; Liu, Zhen Guo

2017-01-01

A fourfold symmetric graphene-based complementary metasurface featuring a polarization-independent transparency window is proposed and numerically analysed in this paper. The unit cell of the metamaterial consists of a monolayer graphene perforated with a cross and four identical split-ring resonators deposited on a substrate. Our analysis shows that the transparency window can be interpreted as a plasmonic analogy of Autler-Townes splitting. The polarization independence is achieved due to the fourfold symmetry of graphene’s complementary structure. In addition, the frequency range of the transparency window can be dynamically tuned over a broad band by changing the chemical potential of graphene, and the width of the transparency window can also be controlled by changing the split-gap orientation. This work may lead to potential applications in many area, such as slow-light devices and optical sensing.

15. High-power, single-frequency, continuous-wave optical parametric oscillator employing a variable reflectivity volume Bragg grating.

PubMed

Zeil, Peter; Thilmann, Nicky; Pasiskevicius, Valdas; Laurell, Fredrik

2014-12-01

A continuous-wave singly-resonant optical parametric oscillator (SRO) with an optimum extraction efficiency, that can be adjusted independent of the pump power, is demonstrated. The scheme employs a variable-reflectivity volume Bragg grating (VBG) as the output coupler of a ring cavity, omitting any additional intra-cavity elements. In this configuration, we obtained a 75%-efficient SRO with a combined signal (19 W @ 1.55 µm) and idler (11 W @ 3.4 µm) output power of 30 W.

16. State-Independent Proof of Kochen—Specker Theorem with Thirty Rank-Two Projectors

NASA Astrophysics Data System (ADS)

Toh, S. P.

2013-10-01

The Kochen—Specker theorem states that noncontextual hidden variable theories are incompatible with quantum mechanics. We provide a state-independent proof of the Kochen—Specker theorem using the smallest number of projectors, i.e., thirty rank-2 projectors, associated with the Mermin pentagram for a three-qubit system.

17. Avoidance of Timeout from Response-Independent Food: Effects of Delivery Rate and Quality

ERIC Educational Resources Information Center

Richardson, Joseph V.; Baron, Alan

2008-01-01

In three experiments, a rat's lever presses could postpone timeouts from food pellets delivered on response-independent schedules. In Experiment 1, the pellets were delivered at variable-time (VT) rates ranging from VT 0.5 to VT 8 min. Experiment 2 replicated the VT 1 min and VT 8 min conditions of Experiment 1 with new subjects. Finally, subjects…

18. Re-Examining Dissociations between Remembering and Knowing: Binary Judgments vs. Independent Ratings

ERIC Educational Resources Information Center

Brown, Aaron A.; Bodner, Glen E.

2011-01-01

When participants must classify their recognition experiences as remembering or knowing, variables often have dissociative effects on the two judgments. In contrast, when participants independently rate recollection "and" familiarity only parallel effects have been reported. To investigate this discrepancy we compared the effects of masked priming…

19. Interactions of Field Independence and General Reasoning with Inductive Instruction in Mathematics.

ERIC Educational Resources Information Center

McLeod, Douglas B.; Briggs, John T.

1980-01-01

The interaction of two aptitude variables, field independence and general reasoning, with treatments that differed in sequence of instruction, was investigated using either an inductive or deductive appraoch to the learning of properties of equivalence relations. Significant interactions were found. (Author/MK)

20. Teacher Language Scaffolds the Development of Independent Strategic Reading Activities and Metacognitive Awareness in Emergent Readers

ERIC Educational Resources Information Center

Lee, Polly A.; Schmitt, Maribeth Cassidy

2014-01-01

This study investigated the influence of teacher language related to a specific network of strategies for problem solving, self-monitoring, and self-correcting on (a) the development and use of independent strategic activities and (b) metacognitive awareness variables in emergent readers. Descriptive analyses of 120 individual lessons conducted…