DOT National Transportation Integrated Search
2014-06-01
Roundabouts are an emerging type of intersection design and a relatively new addition to the : transportation system in the United States. This imposes two traffic engineering and research : related issues. First, data and research on traffic operati...
Accounting Issues: An Essay Series Part VII--Liabilities
ERIC Educational Resources Information Center
Laux, Judy
2008-01-01
This article, the seventh in the series, presents accounting for liabilities along with some related conceptual and measurement issues. Additional coverage is devoted to potential ethical dilemmas and both theoretical and empirical literature related to this set of accounting elements.
Special Issues in Working with Gifted Minority Adolescents.
ERIC Educational Resources Information Center
Lindstrom, Rena R.; Van Sant, Sondra
1986-01-01
Gifted adolescents from minority groups face the same issues all gifted young people face, but the addition of racial and cultural factors increases the complexity of these issues. Discusses individual versus cultural pressures that affect identity, issues related to assisting students with long-range planning, and two models for programming.…
Accounting Issues: An Essay Series Part VI--Investments in Securities
ERIC Educational Resources Information Center
Laux, Judy
2008-01-01
The sixth in a series of theory-based essays, this article presents accounting for investments in debt and equity securities along with some related conceptual and measurement issues. Additional coverage is devoted to potential ethical dilemmas and both theoretical and empirical literature related to this asset. (Contains 1 footnote.)
Attitudes toward Career Counseling: The Role of Public and Self-Stigma
ERIC Educational Resources Information Center
Ludwikowski, Wyndolyn M. A.; Vogel, David; Armstrong, Patrick Ian
2009-01-01
Although many students struggle with career-related issues in college, comparatively few engage the career services offered by their academic institutions for help with their difficulties. In addition, there is little research on the factors influencing students' decisions to engage in counseling for career-related issues, making it difficult to…
Variations in Conflictual Family Issues by Adolescent Pubertal Status, Gender, and Family Member.
ERIC Educational Resources Information Center
Papini, Dennis R.
Conflictual family issues appearing during adolescence have not been adequately dimensionalized. In addition to this problem, researchers have focused on age-related variations in family conflicts without investigating other characteristics. A study was conducted to describe organized domains of conflictual family issues and to describe variations…
Egbert, Nichole; Child, Jeffrey T; Lin, Mei-Chen; Savery, Carol; Bosley, Tammy
2017-04-17
For older adults, approaching end-of-life (EOL) brings unique transitions related to family relationships. Unfortunately, most families greatly underestimate the need to discuss these difficult issues. For example, parents approaching EOL issues often struggle with receiving assistance from others, avoiding family conflict, and maintaining their sense of personhood. In addition, discussions of EOL issues force family members to face their parents' mortality, which can be particularly difficult for adult children to process emotionally. This study explored aging issues identified by aging parents and their families as they traverse these impending EOL changes. Ten focus groups of seniors ( n = 65) were conducted. Focus groups were organized according to race (African-American/European-American), gender, and whether the older adult was living independently or in an assisted care facility. When asked open-ended questions about discussing aging and EOL issues with family members, participants revealed tensions that led us to consider Relational Dialectics Theory as a framework for analysis. The predominant tension highlighted in this report was certainty versus uncertainty, with the two sub-themes of sustained life versus sustained personhood and confronting versus avoiding EOL issues. For these data, there were more similarities than differences as a result of gender, race, or living situation than one might expect, although culture and financial status were found to be influential in the avoidance of EOL discussions. The results of this study help to provide additional insight into relational dialectics related to aging, EOL, and the importance of communication in facilitating family coping.
Reflections on a Decade of Changes in Homeschooling and the Homeschooled into Higher Education
ERIC Educational Resources Information Center
Gloeckner, Gene W.; Jones, Paul
2013-01-01
This article reviews selected research on successes of homeschooled students over the past decade. The article raises several methods issues, especially related to sampling issues and recent changes in some state laws. In addition the article reviews research collected from college admission's officers' on their perceptions and attitudes relate to…
Spouse Employment in the Army: Research Findings
1990-03-01
Teplitzky, Thomas, & Nogami, 1988). In addition to being affected by the broader work-family issues which influence most employed wives, married women...resolve this important family issue . Procedure: A major effort of the Army Family Research Program (AFRP) has been the primary and secondary analyses...19 Spouse Earnings .......... ........................... .... 20 RELATED SPOUSE EMPLOYMENT ISSUES
Related Critical Psychometric Issues and Their Resolutions during Development of PE Metrics
ERIC Educational Resources Information Center
Fox, Connie; Zhu, Weimo; Park, Youngsik; Fisette, Jennifer L.; Graber, Kim C.; Dyson, Ben; Avery, Marybell; Franck, Marian; Placek, Judith H.; Rink, Judy; Raynes, De
2011-01-01
In addition to validity and reliability evidence, other psychometric qualities of the PE Metrics assessments needed to be examined. This article describes how those critical psychometric issues were addressed during the PE Metrics assessment bank construction. Specifically, issues included (a) number of items or assessments needed, (b) training…
78 FR 6273 - Rules Relating to Additional Medicare Tax
Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-30
... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Parts 1 and 31 [REG-130074-11] RIN 1545-BK54 Rules Relating to Additional Medicare Tax Correction In proposed rule document 2012-29237, appearing on pages 72268- 72277 in the issue of Wednesday, December 5, 2012, make the following correction...
The Future of Big-City Schools; Desegregation Policies and Magnet Alternatives.
ERIC Educational Resources Information Center
Levine, Daniel U., Ed.; Havighurst, Robert J., Ed.
This book provides an in-depth analysis of urban education and related issues. The issues examined are not only fundamentally important for urban education, but in addition, several issues that have recently become prominent in considering the future of big cities are discussed. For instance, the effects of desegregation on middle class enrollment…
ERIC Educational Resources Information Center
Hefuna, M.
Presented is a bibliography of science policy literature. This issue contains more than 60 pages of categorized listings, as well as additional materials on resources, positions, teaching programs, and activities of scientific associations. The series of four issues is terminated with this issue. Notes on new institutional developments relate to…
Rosenkrantz, Andrew B; Johnson, Evan; Sanger, Joseph J
2015-10-01
This article presents our local experience in the implementation of a real-time web-based system for reporting and tracking quality issues relating to abdominal imaging examinations. This system allows radiologists to electronically submit examination quality issues during clinical readouts. The submitted information is e-mailed to a designate for the given modality for further follow-up; the designate may subsequently enter text describing their response or action taken, which is e-mailed back to the radiologist. Review of 558 entries over a 6-year period demonstrated documentation of a broad range of examination quality issues, including specific issues relating to protocol deviation, post-processing errors, positioning errors, artifacts, and IT concerns. The most common issues varied among US, CT, MRI, radiography, and fluoroscopy. In addition, the most common issues resulting in a patient recall for repeat imaging (generally related to protocol deviation in MRI and US) were identified. In addition to submitting quality problems, radiologists also commonly used the tool to provide recognition of a well-performed examination. An electronic log of actions taken in response to radiologists' submissions indicated that both positive and negative feedback were commonly communicated to the performing technologist. Information generated using the tool can be used to guide subsequent quality improvement initiatives within a practice, including continued protocol standardization as well as education of technologists in the optimization of abdominal imaging examinations.
Wilderness Medicine Newsletter, Volume 5.
ERIC Educational Resources Information Center
Wilderness Medicine Newsletter, 1994
1994-01-01
This volume of newsletters addresses issues related to the treatment and prevention of medical emergencies in the wilderness. Each issue includes feature articles, book reviews, product reviews, letters to the editor, notices of upcoming wilderness conferences and training courses, additional resources, and general information relevant to medical…
Accounting Issues: An Essay Series Part V--Intangible Assets
ERIC Educational Resources Information Center
Laux, Judy
2008-01-01
This article represents the fifth in a series of theoretical essays intended to supplement the introductory financial accounting course and investigates the accounting treatment and related conceptual connections for intangibles. In addition, intangibles present unique accounting issues, conceptual challenges, and measurement dilemmas not found…
ERIC Educational Resources Information Center
Salomone, Ronald E., Ed.
1985-01-01
Because of the wide and continuing interest in a previous issue on techniques for teaching works by Shakespeare, this journal issue presents 19 additional articles on a broad range of Shakespeare related topics. Following an introduction, the titles of the articles and their authors are as follows: (1) "Making Changes/Making Sense"…
DOT National Transportation Integrated Search
1997-01-20
This paper reviews aviation safety data and measurement issues relevant to the determination of the best means of providing safety information to the public while ensuring the integrity of the aviation safety system. In addition , the paper examines ...
Connecticut Graduation Rates. A ConnCAN Issue Brief
ERIC Educational Resources Information Center
Alexander, Jennifer; Spurrier, Alex; Sauer, Jordan
2011-01-01
For the past five years, ConnCAN (Connecticut Coalition for Achievement Now) has analyzed the state's graduation rates; this Issue Brief provides a more detailed examination of the latest data. In addition to relatively flat graduation rates across the board in Connecticut, the data reveal dramatic, persistent gaps by race. These numbers point to…
ERIC Educational Resources Information Center
Federal Council for Science and Technology, Washington, DC. Committee on Scientific and Technical Information.
An ad hoc task group was constituted by the Committee on Scientific and Technical Information (COSATI) to: (1) delineate present and future issues issues for COSATI, (3) recommend additions or deletions in the present copyright law or in the pending revision now in Congress, and (4) recommend other short or long-term actions related to authorship…
Newman, Michelle G
2016-09-01
This is the introduction to the first of two special issues in honor of the 50th anniversary of the Association for Behavioral and Cognitive Therapies. The goal of this issue is to pay tribute to prior seminal Behavior Therapy publications on etiology and mechanisms of change, to provide an updated review of important topics covered by these papers, and to make recommendations for the future. Each invited paper highlights a particular Behavior Therapy publication's contribution to our understanding and also provides an updated review or meta-analysis on the topic of the original paper. The topics covered here include mechanisms of etiology such as preparedness, reinforcement, and control. In terms of papers on mechanisms of change, we cover mechanisms related to extinction including fear activation, within- and between-session extinction, safety behaviors, and variables related to imagery. In addition, we examine principles related to generalization of learning and optimizing the impact of homework. With the two special issues of Behavior Therapy, we hope to inspire additional research and discussion. Copyright © 2016. Published by Elsevier Ltd.
Emotion-Related Self-Regulation in Children
ERIC Educational Resources Information Center
Eisenberg, Nancy; Sulik, Michael J.
2012-01-01
In this article, the authors review basic conceptual issues in research on children's emotion-related self-regulation, including the differentiation between self-regulation that is effortful and voluntary and control-related processes that are less amenable to effortful control. In addition, the authors summarize what researchers know about…
Calhoun, James A
2006-02-01
The interest and attention devoted to executive functions has grown steadily in the last several decades. The concept and definitions of executive functions and their association with certain disorders such as autism spectrum disorders (ASD) and overall cognitive, social, emotional, and behavioral functioning are important knowledge areas for those working in education, health, and mental health-related fields. It is particularly important for providers to have an understanding of the basic issues related to assessment and remediation of executive dysfunction. This article briefly addresses the background, current definitions, research, and some intervention options associated with executive functions. The intent is to present a foundation for encouraging additional research on the issues relevant to this important topic.
12 CFR 308.180 - Further proceedings.
Code of Federal Regulations, 2014 CFR
2014-01-01
... PRACTICE AND PROCEDURE Rules and Procedures Relating to the Recovery of Attorney Fees and Other Expenses... further proceedings such as an informal conference, oral argument, additional written submissions, or an... identify the information sought or the issues in dispute and shall explain why additional proceedings are...
12 CFR 308.180 - Further proceedings.
Code of Federal Regulations, 2010 CFR
2010-01-01
... PRACTICE AND PROCEDURE Rules and Procedures Relating to the Recovery of Attorney Fees and Other Expenses... further proceedings such as an informal conference, oral argument, additional written submissions, or an... identify the information sought or the issues in dispute and shall explain why additional proceedings are...
12 CFR 308.180 - Further proceedings.
Code of Federal Regulations, 2011 CFR
2011-01-01
... PRACTICE AND PROCEDURE Rules and Procedures Relating to the Recovery of Attorney Fees and Other Expenses... further proceedings such as an informal conference, oral argument, additional written submissions, or an... identify the information sought or the issues in dispute and shall explain why additional proceedings are...
12 CFR 308.180 - Further proceedings.
Code of Federal Regulations, 2012 CFR
2012-01-01
... PRACTICE AND PROCEDURE Rules and Procedures Relating to the Recovery of Attorney Fees and Other Expenses... further proceedings such as an informal conference, oral argument, additional written submissions, or an... identify the information sought or the issues in dispute and shall explain why additional proceedings are...
NASA Technical Reports Server (NTRS)
Abbott, Larry; Cox, Gary; Nguyen, Hai
2000-01-01
This article addresses the issues associated with adapting the commercial PC104Plus standard and its associated architecture to the requirements of space applications. In general, space applications exhibit extreme constraints on power, weight, and volume. EMI and EMC are also issues of significant concern. Additionally, space applications have to survive high radiation environment. Finally, NASA is always concerned about achieving cost effective solutions that are compatible with safety and launch constraints. Weight and volume constraints are directly related to high launch cost. Power on the other hand is not only related to the high launch costs, but are related to the problem of dissipating the resulting heat once in space. The article addresses why PC104Plus is an appropriate solution for the weight and volume issues. The article also addresses what NASA did electrically to reduce power consumption and mechanically dissipate the associated heat in a microgravity and vacuum environment, and how these solutions allow NASA to integrate various sizes of ruggedized custom PC104 boards with COTS, PC104 complaint boards for space applications. In addition to the mechanical changes to deal with thermal dissipation NASA also made changes to minimize EMI. Finally, radiation issues are addressed as well as the architectural and testing solutions and the implications for use of COTS PC104Plus boards.
Ethical issues in HIV prevention research with people who inject drugs.
Sugarman, Jeremy; Rose, Scott M; Metzger, David
2014-04-01
Injection drug use continues to significantly contribute to new infections with HIV. Moreover, conducting HIV prevention research with people who inject drugs (PWIDs) can be complicated for an array of practical, social, legal, and ethical reasons. It is critical that these research efforts are sensitive to the particular vulnerabilities associated with injection drug use as well as those related to being at risk of acquiring HIV so as to minimize harm to participants in research. To describe how we addressed some of these ethical challenges during the course of a large-scale multinational randomized HIV prevention trial involving PWIDs, which was successfully completed. The ethical issues encountered during the life cycle of the trial were cataloged by the principal investigator, study coordinator, and ethicist working on the trial. Relevant study documents were then reviewed to provide pertinent details. The ethical issues unique to the trial were then described. Before implementation, the trial faced particularly complex challenges related to the vulnerability of PWIDs, where HIV seroincidence rates in the population were high and legal policies and stigma regarding injection drug use was severe. Accordingly, a rapid policy assessment was commissioned, and a series of community engagement activities were conducted. During the trial, in addition to using careful standard operating procedures regarding all aspects of trial conduct and extensive staff training, the trial standardized informed consent procedures and assessed them. Furthermore, social harms were monitored along with physical harms and adverse events. Following the decision to close the study, it was critical to develop an orderly and safe process for closing it. The issue of post-trial access to the study medication and a complex intervention also surfaced for consideration. The issues described in this article are necessarily limited to how they manifested themselves within the context of a particular trial that was conducted in two countries. In addition, other stakeholders may have divergent views on the ethical issues described and may also have identified additional ethical issues that would warrant examination. Adopting similar approaches to addressing ethical issues in future research promises to facilitate this work so that needed strategies to prevent HIV infection among PWIDs can be safely and appropriately tested. Future trials enrolling PWIDs who are at risk of detainment should identify ways of mapping closely their experiences and perceptions in order to better apprehend some of the ethical issues at stake. In addition, scholarly and policy work needs to address the ethical issues related to post-trial access to multi-modal interventions that may be desired by participants, but are not shown to be effective in achieving the primary outcomes of the study.
2008-06-01
The new issue areas included any intelligence activities relating to Iraq conducted by the Policy Counterterrorism Evaluation Group and the Office of...Special Plans within the Office of the Under Secretary of Defense for Policy. The Committee pursued this issue area in 2004, but subsequently the Committee’s attention was placed on other aspects of the terms of reference.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-05
... by email to [email protected]bioethics.gov or by mail to the following address: Public Commentary, Presidential... Study of Bioethical Issues. Telephone: 202-233-3960. E-Mail: [email protected]bioethics.gov . Additional information may be obtained at http://www.bioethics.gov . SUPPLEMENTARY INFORMATION: On November 24, 2009, the...
Interests of 5th through 10th Grade Students Regarding Enviromental Protection Issues
ERIC Educational Resources Information Center
Erten, Sinan
2015-01-01
This study investigates the extent of interest among middle and high school students in environmental protection issues along with the sources of their interests and factors that impact their interests, namely people with whom they interact and courses that they take related to the environment, science and technology. In addition, it is confirmed…
Socioscientific Issues in Science Education: The Case of Turkey
ERIC Educational Resources Information Center
Topcu, Mustafa Sami; Mugaloglu, Ebru Zeynep; Guven, Devrim
2014-01-01
The purpose of this study is to identify the foci and results of studies on socioscientific issues (SSI) conducted in Turkey. Additionally, the study aimed to compare the results of this study with ones conducted internationally. For this aim, a literary review of empirical studies related to SSI conducted in Turkey was carried out. Four criteria…
Jordan: U.S. Relations and Bilateral Issues
2007-12-04
international issues over the years. The country’s small size and lack of major economic resources have made it dependent on aid from Western and friendly Arab...million ( $1.0 above the request) in International Counter- Narcotics and Law Enforcement funds. The Senate’s version would provide an additional $200.0...States and Jordan have never been linked by a formal treaty, they have cooperated on a number of regional and international issues over the years. The
NASA Technical Reports Server (NTRS)
Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.
2010-01-01
This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.
MANUAL: REAL TIME CONTROL OF COMBINED SEWERS
Managers, engineers, and operators of combined urban sewer systems are faced with difficult problems related to the operation and maintenance of their facilities. In addition to the issues related to the operation and upkeep of the system, many sewerage agencies are facing increa...
Rotavirus Vaccines: a story of success with challenges ahead
O’Ryan, Miguel
2017-01-01
Approximately 40 years have passed since the discovery of the rotavirus and 10 years since the introduction and progressive dissemination of rotavirus vaccines worldwide. Currently, 92 countries have introduced rotavirus vaccines into national or subnational programs with evident impact in disease reduction. Two vaccines have been widely used, and four additional vaccines have been licensed and are being used in defined regions. In this context, one main issue that remains unsolved is the lower vaccine efficacy/effectiveness in low-income countries. An additional partially answered issue relates to rotavirus strain circulation in vaccinated populations. These issues are discussed in this review. The most imperative challenge ahead is to fulfill the WHO’s recommendation to introduce rotavirus vaccines in all countries. PMID:28928954
Water-Related Power Plant Curtailments: An Overview of Incidents and Contributing Factors
DOE Office of Scientific and Technical Information (OSTI.GOV)
McCall, James; Macknick, Jordan; Macknick, Jordan
Water temperatures and water availability can affect the reliable operations of power plants in the United States. Data on water-related impacts on the energy sector are not consolidated and are reported by multiple agencies. This study provides an overview of historical incidents where water resources have affected power plant operations, discusses the various data sources providing information, and creates a publicly available and open access database that contains consolidated information about water-related power plant curtailment and shut-down incidents. Power plants can be affected by water resources if incoming water temperatures are too high, water discharge temperatures are too high, ormore » if there is not enough water available to operate. Changes in climate have the potential to exacerbate uncertainty over water resource availability and temperature. Power plant impacts from water resources include curtailment of generation, plant shut-downs, and requests for regulatory variances. In addition, many power plants have developed adaptation approaches to reducing the potential risks of water-related issues by investing in new technologies or developing and implementing plans to undertake during droughts or heatwaves. This study identifies 42 incidents of water-related power plant issues from 2000-2015, drawing from a variety of different datasets. These incidents occur throughout the U.S., and affect coal and nuclear plants that use once-through, recirculating, and pond cooling systems. In addition, water temperature violations reported to the Environmental Protection Agency are also considered, with 35 temperature violations noted from 2012-2015. In addition to providing some background information on incidents, this effort has also created an open access database on the Open Energy Information platform that contains information about water-related power plant issues that can be updated by users.« less
How Teachers Need to Deal with the Seen, the Unseen, the Improbable, and the Nearly Imponderable
ERIC Educational Resources Information Center
Gregory, Marshall
2010-01-01
In addition to dealing with the more or less obvious variables that affect classroom dynamics, teachers need to learn how to deal with the far more difficult issues related to learning, identity, selfhood, and autonomy. In this article, the author first discusses classroom issues that are most visible and vivid for teachers. Next, the author…
ERIC Educational Resources Information Center
Blount, Ronald L.; Piira, Tiina; Cohen, Lindsey L.; Cheng, Patricia S.
2006-01-01
This article reviews the various settings in which infants, children, and adolescents experience pain during acute medical procedures and issues related to referral of children to pain management teams. In addition, self-report, reports by others, physiological monitoring, and direct observation methods of assessment of pain and related constructs…
American Journal of Physics Resource Letters - The Future of Nuclear Power
DOE Office of Scientific and Technical Information (OSTI.GOV)
Parks, Cecil V; Flanagan, George F; Kulynych, George E
2010-01-01
This Resource Letter is intended to summarize the status of nuclear power in the world today, prospects of significant expansion of nuclear power over the next several decades, the planning of and forecasts for the addition of new power reactors, and issues surrounding the addition of these new reactors. Owing to the breadth of this subject, the list of references includes journal articles, web pages, and reports to guide the reader on the subject. The subject of nuclear power and its related issues are dynamic, so the most current information is likely to be found on reputable websites.
Modelling of additive manufacturing processes: a review and classification
NASA Astrophysics Data System (ADS)
Stavropoulos, Panagiotis; Foteinopoulos, Panagis
2018-03-01
Additive manufacturing (AM) is a very promising technology; however, there are a number of open issues related to the different AM processes. The literature on modelling the existing AM processes is reviewed and classified. A categorization of the different AM processes in process groups, according to the process mechanism, has been conducted and the most important issues are stated. Suggestions are made as to which approach is more appropriate according to the key performance indicator desired to be modelled and a discussion is included as to the way that future modelling work can better contribute to improving today's AM process understanding.
Identification of Crew-Systems Interactions and Decision Related Trends
NASA Technical Reports Server (NTRS)
Jones, Sharon Monica; Evans, Joni K.; Reveley, Mary S.; Withrow, Colleen A.; Ancel, Ersin; Barr, Lawrence
2013-01-01
NASA Vehicle System Safety Technology (VSST) project management uses systems analysis to identify key issues and maintain a portfolio of research leading to potential solutions to its three identified technical challenges. Statistical data and published safety priority lists from academic, industry and other government agencies were reviewed and analyzed by NASA Aviation Safety Program (AvSP) systems analysis personnel to identify issues and future research needs related to one of VSST's technical challenges, Crew Decision Making (CDM). The data examined in the study were obtained from the National Transportation Safety Board (NTSB) Aviation Accident and Incident Data System, Federal Aviation Administration (FAA) Accident/Incident Data System and the NASA Aviation Safety Reporting System (ASRS). In addition, this report contains the results of a review of safety priority lists, information databases and other documented references pertaining to aviation crew systems issues and future research needs. The specific sources examined were: Commercial Aviation Safety Team (CAST) Safety Enhancements Reserved for Future Implementation (SERFIs), Flight Deck Automation Issues (FDAI) and NTSB Most Wanted List and Open Recommendations. Various automation issues taxonomies and priority lists pertaining to human factors, automation and flight design were combined to create a list of automation issues related to CDM.
Evaluating Drugs and Food Additives for Public Use: A Case Studies Approach.
ERIC Educational Resources Information Center
Merritt, Sheridan V.
1980-01-01
Described is a case study used in an introductory college biology course that provides a basis for generating debate on an issue concerning the regulation of controversial food additives and prescription drugs. The case study contained within this article deals with drug screening, specifically with information related to thalidomide. (CS)
Measles and rubella eradication.
Hinman, Alan R
2018-01-02
This article discusses concepts of eradication, some issues relating to vertical and horizontal public health programs, some current issues relating to measles and rubella, and what we need to do about them. It concludes that measles and rubella/CRS can and should be eradicated. A target date should be established in 2020 (or before). Eradication can only be accomplished in the context of strengthening ongoing immunization services and strengthening surveillance so it can guide activities. Additional resources will be required to achieve the goal. Copyright © 2017 Elsevier Ltd. All rights reserved.
Finding online health-related information: usability issues of health portals.
Gurel Koybasi, Nergis A; Cagiltay, Kursat
2012-01-01
As Internet and computers become widespread, health portals offering online health-related information become more popular. The most important point for health portals is presenting reliable and valid information. Besides, portal needs to be usable to be able to serve information to users effectively. This study aims to determine usability issues emerging when health-related information is searched on a health portal. User-based usability tests are conducted and eye movement analyses are used in addition to traditional performance measures. Results revealed that users prefer systematic, simple and consistent designs offering interactive tools. Moreover, content and partitions needs to be shaped according to the medical knowledge of target users.
Determinants of Interest Rates on Corporate Bonds of Mining Enterprises
NASA Astrophysics Data System (ADS)
Ranosz, Robert
2017-09-01
This article is devoted to the determinants of interest rates on corporate bonds of mining enterprises. The study includes a comparison between the cost of foreign capital as resulting from the issue of debt instruments in different sectors of the economy in relation to the mining industry. The article also depicts the correlation between the rating scores published by the three largest rating agencies: S&P, Moody's, and Fitch. The test was based on simple statistical methods. The analysis performed indicated that there is a dependency between the factors listed and the amount of interest rates on corporate bonds of global mining enterprises. Most significant factors include the rating level and the period for which the given series of bonds was issued. Additionally, it is not without significance whether the given bond has additional options. Pursuant to the obtained results, is should be recognized that in order to reduce the interest rate on bonds, mining enterprises should pay particular attention to the rating and attempt to include additional options in issued bonds. Such additional options may comprise, for example, an ability to exchange bonds to shares or raw materials.
Ong, Leonard; Elnajjar, Pierre; Nyman, C Gregory; Mair, Thomas; Juluru, Krishna
2017-07-01
We implemented an Image Quality Reporting and Tracking Solution (IQuaRTS), directly linked from the PACS, to improve communication between radiologists and technologists. IQuaRTS launched in May 2015. We compared MRI issues filed in the period before IQuaRTS implementation (May-September 2014) using a manual system with MRI issues filed in the IQuaRTS period (May-September 2015). The unpaired t test was used for analysis. For assessment of overall results in the IQuaRTS period alone, all issues filed across all modalities were included. Summary statistics and charts were generated using Excel and Tableau. For MRI issues, the number of issues filed during the IQuaRTS period was 498 (2.5% of overall MRI examination volume) compared with 78 issues filed during the period before IQuaRTS implementation (0.4% of total examination volume) (p = 0.0001), representing a 625% relative increase. Tickets that documented excellent work were 8%. Other issues included images not pushed to PACS (20%), film library issues (19%), and documentation or labeling (8%). Of the issues filed, 55% were MRI-related and 25% were CT-related. The issues were stratified across six sites within our institution. Staff requiring additional training could be readily identified, and 80% of the issues were resolved within 72 hours. IQuaRTS is a cost-effective online issue reporting tool that enables robust data collection and analytics to be incorporated into quality improvement programs. One limitation of the system is that it must be implemented in an environment where staff are receptive to quality improvement.
Baker, Anne; Galvin, Jane; Vale, Lisa; Lindner, Helen
2012-02-01
This research project aimed to understand the challenges faced by occupational therapists when making recommendations regarding the restraint of children with additional needs in motor vehicles in Victoria, Australia. A cross-sectional survey design was used to explore current practice in relation to the prescription of motor vehicle restraints in Victoria, Australia. An electronic survey was sent to occupational therapists working with children aged from birth to 18 years in early intervention services, hospitals, schools, community services or private practice. Challenges faced by occupational therapists related to a lack of knowledge of relevant standards and legal requirements, issues seating children with behavioural difficulties, families' inability to purchase recommended equipment and constraints as a result of funding issues. Further work is required to develop appropriate resources which support occupational therapists to make car seating recommendations for children with additional needs which comply with Australian legal requirements and standards. © 2011 The Authors. Australian Occupational Therapy Journal © 2011 Occupational Therapy Australia.
77 FR 43567 - Medical Area Body Network
Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-25
... document requests comment on a number of issues related to the designation of Medical Body Area Network... also determined that additional notice and comment was required on key aspects related to the process and criteria for designating an MBAN coordinator. DATES: Comments must be filed on or before September...
DOT National Transportation Integrated Search
2003-01-01
Surveys, interviews and site visits were used to identify, observe and document geotechnical-related problems in Missouri DOT infrastructure. Documented issues were evaluated and prioritized. Additional attention was focused on Pavement Edge Drains a...
Re-Evaluating Evidence for Linguistic Relativity: Reply to Boroditsky (2001)
ERIC Educational Resources Information Center
January, David; Kako, Edward
2007-01-01
Six unsuccessful attempts at replicating a key finding in the linguistic relativity literature [Boroditsky, L. (2001). Does language shape thought?: Mandarin and English speakers' conceptions of time. "Cognitive Psychology," 43, 1-22] are reported. In addition to these empirical issues in replicating the original finding, theoretical issues…
Emotion-Related Regulation: An Emerging Construct
ERIC Educational Resources Information Center
Eisenberg, Nancy; Champion, Claire; Ma, Yue
2004-01-01
Emotion-related regulation is a topic of considerable current interest; however, this was not always true. We briefly discuss the history of interest in the topic and then the current state of the field, including definitions of the construct. In addition, we summarize some of the important issues for future attention, including definitional…
Ethical aspects of tissue engineering: a review.
de Vries, Rob B M; Oerlemans, Anke; Trommelmans, Leen; Dierickx, Kris; Gordijn, Bert
2008-12-01
Tissue engineering (TE) is a promising new field of medical technology. However, like other new technologies, it is not free of ethical challenges. Identifying these ethical questions at an early stage is not only part of science's responsibility toward society, but also in the interest of the field itself. In this review, we map which ethical issues related to TE have already been documented in the scientific literature. The issues that turn out to dominate the debate are the use of human embryonic stem cells and therapeutic cloning. Nevertheless, a variety of other ethical aspects are mentioned, which relate to different phases in the development of the field. In addition, we discuss a number of ethical issues that have not yet been raised in the literature.
The impact of globalisation, free trade and technology on food and nutrition in the new millennium.
McMichael, P
2001-05-01
The millennium promises a dramatic politicisation of the food question. In addition to the prominent issues of food security, hunger and nutrition, bioengineering, food safety and quality, there are related issues of environmental sustainability, power, sovereignty and rights. All these issues are deeply implicated in the current corporate form of globalisation, which is transforming historic global arrangements by subordinating public institutions and the question of food security to private solutions. The present paper questions the self-evident association between globalisation and nutritional improvement.
Pharmacologic issues in management of chronic disease.
DeSevo, Gina; Klootwyk, Jacqueline
2012-06-01
A significant portion of the adult population uses one or more medications on a regular basis to manage chronic conditions. As the number of medications that patients are prescribed increases, an increase in pharmacologic-related issues and complications may occur, such as polypharmacy, inappropriate prescribing, medication nonadherence and nonpersistence, and adverse drug reactions and events. Risk factors and consequences of these issues have been identified and are discussed in this article. In addition, a review is presented of the numerous methods that have been evaluated to help prevent and minimize these pharmacologic issues in the management of chronic disease. Copyright © 2012 Elsevier Inc. All rights reserved.
Code of Federal Regulations, 2010 CFR
2010-07-01
..., the parties may submit any additional relevant information relating to the violation, either prior to... to submit additional information or request a safety and health conference with the District Manager... parties to discuss the issues involved prior to the conference. (d) MSHA will consider all relevant...
1989 Exclusive Economic Zone Symposium: summary and recommendations
Lockwood, M.; Hill, G.W.
1989-01-01
Issues discussed relate to digital seafloor mapping projects, cooperative federal-state programs, and requirements for additional data and information. Symposium recommendations included the need for increased surveying in coastal waters, development of standards for digital data dissemination, increased coordination with coastal states and federal agencies, and additional geophysical measurement systems abroad all mapping ships. -from Authors
Parenting Outcomes of Single Active Duty Postpartum Women
1998-04-15
Single active duty mothers face many of the same stressors as civilian single parents, including role strain, child care issues, and lack of...discretionary time. Child care is a difficult issue for single parents who need care that is flexible, convenient, and available at a reasonable cost...Deployments, work related travel, shift work, and relocations pose additional and unique problems for child care arrangements for military (Wahl & Randall
Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-03
... research related to the Deepwater Horizon/BP oil spill in the Gulf of Mexico. To date, an additional nine... issued solely for research related to the Deepwater Horizon/BP oil spill research in the Gulf of Mexico... for research related to the oil spill in the Gulf of Mexico. Table 1--Summary of HMS Exempted Permits...
A survey of sports medicine physicians regarding psychological issues in patient-athletes.
Mann, Barton J; Grana, William A; Indelicato, Peter A; O'Neill, Daniel F; George, Steven Z
2007-12-01
To determine the extent to which sports medicine physicians encounter and discuss psychological issues among athletes they treat and to evaluate physicians' perceptions of the availability and efficacy of sport psychologists and other mental health resources. Cross-sectional study. A survey was sent via e-mail to all physician members of 4 prominent sports medicine professional associations: the American Orthopaedic Society for Sports Medicine, American College of Sports Medicine, American Medical Society for Sports Medicine, and American Osteopathic Academy of Sports Medicine. The extent to which respondents discuss psychological issues with athletes varied by subspecialty and by specific issues assessed. Fears about reinjury, fears related to surgery, and lack of patience with recovery/rehabilitation were the 3 most common injury-related topics discussed with patient-athletes. The 3 most common non-injury-related topics discussed were stress/pressure, anxiety, and burnout. Family practitioners were more likely to discuss injury-related psychological issues than were orthopaedic surgeons. Orthopaedic surgeons reported the lowest frequencies of discussing non-injury-related psychological issues. Only 19% of all respondents indicated there were adequate numbers of sport psychologists and other mental health professionals in their geographical area to treat the needs of athletes. Three quarters of respondents reported they rarely or never referred athletes to sport psychologists for injury-related issues, and two thirds indicated they rarely or never referred athletes to sport psychologists for non-injury-related problems. Respondents rated sport psychologists and athletic trainers/physical therapists to be moderately effective in working with athletes regarding psychological problems. Sports medicine physicians frequently encounter psychological issues with patient-athletes. There is a need for tools to facilitate assessment of these problems as well as greater communication between the mental health community and sports medicine physicians. In addition, knowledge of and access to professionals who are specifically trained to deal with the sometimes unique psychological needs of athletes should be improved.
Sullivan, Tami P; Weiss, Nicole H; Price, Carolina; Pugh, Nicole E
2017-10-01
Criminal protection orders (POs), with varying degrees of restrictions, are issued by the criminal justice system to enhance the safety of victims of domestic violence (DV). Limited research exists to elucidate factors associated with their issuance. Therefore, the purpose of this study was to investigate how demographic, relationship, parenting, and court-process-related factors are related to the level of restriction the PO places on the offender. Two-hundred ninety-eight women who were victims in a criminal DV case ( M age 36.4, 50.0% African American) participated in a structured interview approximately 12 to 15 months following the offenders' arraignment. Results revealed that psychological DV severity and fear of the offender in the 30 days prior to arraignment significantly predicted PO level of restriction issued. In addition, level of restriction requested by the victim significantly predicted level of restriction issued by the judge (though closer examination of the data revealed that many orders were issued at a different level of restriction than the victim requested). Other demographic, relationship, parenting, and court-process-related factors did not predict PO level of restriction issued. Findings are discussed with respect to practice and policy in the criminal justice system.
Buechner, Bianca
2012-01-01
The Presidential Commission for the Study of Bioethical Issues suggested in its report "Research Across Borders: Proceedings of the International Research Panel of the Presidential Commission for the Study of Bioethical Issues" that the United States should implement a system to compensate research subjects for research-related injuries. This article not only analyzes the Commission's recommendation critically, but also discusses if an ethical obligation exists to compensate study subjects for research-related injuries. In addition, the article compares the status quo of the United States to the one in Germany. Germany is one of the countries, which has an established insurance system for research-related injuries based on a non-fault system.
Women and traumatic brain injury.
Bell, K R; Pepping, M
2001-02-01
Women with TBI have been inadequately studied in relation to most aspects of pathophysiology, recovery, health and behavioral issues, and community integration. This is not entirely surprising in light of the preponderance of men with TBI but also reflects the traditional tendency of medical researchers to concentrate their efforts on men. Although most of the residual effects of TBI are gender-neutral, women may present some unique problems in relation to pain and endocrine issues, reproduction, and sexual functioning In addition, a woman's roles as wife, mother, and daughter are likely to result in a different constellation of family dynamics when TBI is introduced. Attention to enrollment of women in research studies and the increasing number of multi-institutional studies of TBI may provide enlightenment on these issues in the future.
Ethical perspectives in neuroscience nursing practice.
Murphy, W J; Olsen, B J
1999-09-01
The role of neuroscience nurses in relation to ethical issues has become increasingly complex. Knowledge of ethical principles and theories assists the nurse in the development of a theoretical basis for resolution of ethical issues or concerns. Additionally, the nurse must possess information regarding practice codes or standards as well as legislative requirements. The nurse must act as an advocate for the patient and society through active participation in institutional ethics committees and legislative forums.
Additive Manufacturing of Biomaterials, Tissues, and Organs.
Zadpoor, Amir A; Malda, Jos
2017-01-01
The introduction of additive manufacturing (AM), often referred to as three-dimensional (3D) printing, has initiated what some believe to be a manufacturing revolution, and has expedited the development of the field of biofabrication. Moreover, recent advances in AM have facilitated further development of patient-specific healthcare solutions. Customization of many healthcare products and services, such as implants, drug delivery devices, medical instruments, prosthetics, and in vitro models, would have been extremely challenging-if not impossible-without AM technologies. The current special issue of the Annals of Biomedical Engineering presents the latest trends in application of AM techniques to healthcare-related areas of research. As a prelude to this special issue, we review here the most important areas of biomedical research and clinical practice that have benefited from recent developments in additive manufacturing techniques. This editorial, therefore, aims to sketch the research landscape within which the other contributions of the special issue can be better understood and positioned. In what follows, we briefly review the application of additive manufacturing techniques in studies addressing biomaterials, (re)generation of tissues and organs, disease models, drug delivery systems, implants, medical instruments, prosthetics, orthotics, and AM objects used for medical visualization and communication.
Ethical Legal and Social Issues of Biobanking: Past, Present, and Future.
Bledsoe, Marianna J
2017-04-01
The past 15 years has seen considerable changes in the research environment. These changes include the development of new sophisticated genetic and genomic technologies, a proliferation of databases containing large amount of genotypic and phenotypic data, and wide-spread data sharing among many institutions, nationally and internationally. These changes have raised new questions regarding how best to protect the participants of biobanking research. In response to these questions, best practices for addressing the legal, ethical, and social issues of biobanking have been developed. In addition, new ethical guidelines related to biobanking have been established, as well as new regulations regarding privacy and human subject protections. Finally, changes in the science and the research environment have raised complex ethical issues related to biobanking, such as questions about the most appropriate consent models to use for biobanking research, commercial use and ownership issues, and whether and how to return individual research results to biobank participants. This article reviews some of the developments over the past 15 years related to the ELSI of biobanking with a look toward the future.
Drug policy, harm and human rights: a rationalist approach.
Stevens, Alex
2011-05-01
It has recently been argued that drug-related harms cannot be compared, so making it impossible to choose rationally between various drug policy options. Attempts to apply international human rights law to this area are valid, but have found it difficult to overcome the problems in applying codified human rights to issues of drug policy. This article applies the rationalist ethical argument of Gewirth (1978) to this issue. It outlines his argument to the 'principle of generic consistency' and the hierarchy of basic, nonsubtractive and additive rights that it entails. It then applies these ideas to drug policy issues, such as whether there is a right to use drugs, whether the rights of drug 'addicts' can be limited, and how different harms can be compared in choosing between policies. There is an additive right to use drugs, but only insofar as this right does not conflict with the basic and nonsubtractive rights of others. People whose freedom to choose whether to use drugs is compromised by compulsion have a right to receive treatment. They retain enforceable duties not to inflict harms on others. Policies which reduce harms to basic and nonsubtractive rights should be pursued, even if they lead to harms to additive rights. There exists a sound, rational, extra-legal basis for the discussion of drug policy and related harms which enables commensurable discussion of drug policy options. Copyright © 2011 Elsevier B.V. All rights reserved.
ERIC Educational Resources Information Center
Hoyer, Grace
2013-01-01
The purpose of this study was to explore transcultural self-efficacy in nursing education administrators/faculty and to gain understanding of confidence related to lesbian, gay, bisexual, transgender (LGBT) issues. The 83-item Transcultural Self-Efficacy Tool (TSET) with an additional 11 LGBT questions was administered to 535 nursing education…
Ethical, legal, and social issues in the translation of genomics into health care.
Badzek, Laurie; Henaghan, Mark; Turner, Martha; Monsen, Rita
2013-03-01
The rapid continuous feed of new information from scientific discoveries related to the human genome makes translation and incorporation of information into the clinical setting difficult and creates ethical, legal, and social challenges for providers. This article overviews some of the legal and ethical foundations that guide our response to current complex issues in health care associated with the impact of scientific discoveries related to the human genome. Overlapping ethical, legal, and social implications impact nurses and other healthcare professionals as they seek to identify and translate into practice important information related to new genomic scientific knowledge. Ethical and legal foundations such as professional codes, human dignity, and human rights provide the framework for understanding highly complex genomic issues. Ethical, legal, and social concerns of the health provider in the translation of genomic knowledge into practice including minimizing harms, maximizing benefits, transparency, confidentiality, and informed consent are described. Additionally, nursing professional competencies related to ethical, legal, and social issues in the translation of genomics into health care are discussed. Ethical, legal, and social considerations in new genomic discovery necessitate that healthcare professionals have knowledge and competence to respond to complex genomic issues and provide appropriate information and care to patients, families, and communities. Understanding the ethical, legal, and social issues in the translation of genomic information into practice is essential to provide patients, families, and communities with competent, safe, effective health care. © 2013 Sigma Theta Tau International.
A widely used gasoline additive, methyl tertiary butyl ether (MTBE), has been controversial, in part because of concerns about potential inhalation health effects and more recently because of added concerns about water contamination. Although many of the issues related to MTBE ha...
Publishing on the WWW. Part 1 - Static graphics
Grech, V
2000-01-01
An on-line journal's ability to publish graphics at no additional cost is a major advantage over conventional printed journals. This article outlines technical, copyright and other issues related to graphic publishing on the world-wide-web. PMID:22368588
NHEERL research is providing the scientific basis for policy decisions regarding the need for an additional safety factor for children, the need to assess cumulative exposures, and the best way to deal with risk management issues related to common mode of action. Research can be ...
The Implications of China’s Economic Statecraft
2012-03-19
the U.S. Monetary Policy , Finance and U.S. Treasury Securities Closely tied to the previously discussed issue of the renminbi exchange rate is the...largely because of its exchange rate policy . In order to limit the appreciation of the renminbi against the dollar, China must purchase U.S. dollars...additional 20 years to inch from one-third to one-half.63 Over-reliance on Foreign Trade. Closely related to its currency exchange policy issues, the
Considerations for preparing collaborative international research: a Ugandan experience.
Musil, Carol M; Mutabaazi, Jemimah; Walusimbi, Mariam; Okonsky, Jennifer G; Biribonwa, Yedidah; Eagan, Sabrina; Dimarco, Marguerite A; Mbaballi, Speciosa; Fitzpatrick, Joyce J
2004-08-01
This article describes issues to consider when planning and conducting international research projects. Key considerations include building collaboration, developing a comprehensive and feasible research plan, funding and budgets, addressing human subjects concerns, and analyzing and disseminating project findings. These considerations and related methodological issues are discussed in the context of a replication pilot project conducted outside Kampala, Uganda. Ongoing dialog, flexibility, and collaboration, in addition to good science, are critical to developing successful international research projects.
DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale
Hasin, Deborah S.; O’Brien, Charles P.; Auriacombe, Marc; Borges, Guilherme; Bucholz, Kathleen; Budney, Alan; Compton, Wilson M.; Crowley, Thomas; Ling, Walter; Petry, Nancy M.; Schuckit, Marc; Grant, Bridget F.
2013-01-01
Since DSM-IV was published in 1994, its approach to substance use disorders has come under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but concerns have also arisen. The DSM-5 Substance-Related Disorders Work Group considered these issues and recommended revisions for DSM-5. General concerns included whether to retain the division into two main disorders (dependence and abuse), whether substance use disorder criteria should be added or removed, and whether an appropriate substance use disorder severity indicator could be identified. Specific issues included possible addition of withdrawal syndromes for several substances, alignment of nicotine criteria with those for other substances, addition of biomarkers, and inclusion of nonsubstance, behavioral addictions. This article presents the major issues and evidence considered by the work group, which included literature reviews and extensive new data analyses. The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, adding cannabis and caffeine withdrawal syndromes, aligning tobacco use disorder criteria with other substance use disorders, and moving gambling disorders to the chapter formerly reserved for substance-related disorders. The proposed changes overcome many problems, while further studies will be needed to address issues for which less data were available. PMID:23903334
DSM-5 criteria for substance use disorders: recommendations and rationale.
Hasin, Deborah S; O'Brien, Charles P; Auriacombe, Marc; Borges, Guilherme; Bucholz, Kathleen; Budney, Alan; Compton, Wilson M; Crowley, Thomas; Ling, Walter; Petry, Nancy M; Schuckit, Marc; Grant, Bridget F
2013-08-01
Since DSM-IV was published in 1994, its approach to substance use disorders has come under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but concerns have also arisen. The DSM-5 Substance-Related Disorders Work Group considered these issues and recommended revisions for DSM-5. General concerns included whether to retain the division into two main disorders (dependence and abuse), whether substance use disorder criteria should be added or removed, and whether an appropriate substance use disorder severity indicator could be identified. Specific issues included possible addition of withdrawal syndromes for several substances, alignment of nicotine criteria with those for other substances, addition of biomarkers, and inclusion of nonsubstance, behavioral addictions.This article presents the major issues and evidence considered by the work group, which included literature reviews and extensive new data analyses. The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, adding cannabis and caffeine withdrawal syndromes, aligning tobacco use disorder criteria with other substance use disorders, and moving gambling disorders to the chapter formerly reserved for substance-related disorders. The proposed changes overcome many problems, while further studies will be needed to address issues for which less data were available.
Nuttall, Frank Q.
2015-01-01
The body mass index (BMI) is the metric currently in use for defining anthropometric height/weight characteristics in adults and for classifying (categorizing) them into groups. The common interpretation is that it represents an index of an individual’s fatness. It also is widely used as a risk factor for the development of or the prevalence of several health issues. In addition, it is widely used in determining public health policies.The BMI has been useful in population-based studies by virtue of its wide acceptance in defining specific categories of body mass as a health issue. However, it is increasingly clear that BMI is a rather poor indicator of percent of body fat. Importantly, the BMI also does not capture information on the mass of fat in different body sites. The latter is related not only to untoward health issues but to social issues as well. Lastly, current evidence indicates there is a wide range of BMIs over which mortality risk is modest, and this is age related. All of these issues are discussed in this brief review. PMID:27340299
Regional Seminars to Address Current Nuclear Export Control Issues
DOE Office of Scientific and Technical Information (OSTI.GOV)
Killinger, Mark H.
2002-07-01
The control of nuclear-related exports, a critical component of the nonproliferation regime, is facing several opportunities and challenges. As countries sign and ratify the International Atomic Energy Agency's (IAEA) safeguards Additional Protocol (AP), they will begin to report far more export information, including exports of a list of items similar to the Nuclear Supplier Group's Trigger List that existed when the AP was developed in the mid-1990s. This positive development contrasts with challenges such as globalization, transshipments, and tracking of end-uses. Pacific Northwest National Laboratory is proposing that the US Department of Energy (DOE) develop regional seminars that address thesemore » types of issues related to export/import controls. The DOE seminars would be designed to supplement regional seminars sponsored by the IAEA and member states on topics related to the Additional Protocol (referred to as "IAEA seminars"). The topic of nuclear export/import controls is not thoroughly addressed in the IAEA seminars. The proposed DOE seminars would therefore have two objectives: familiarizing countries with the export/import provisions of the Additional Protocol, and addressing challenges such as those noted above. The seminars would be directed particularly at countries that have not ratified the AP, and at regions where export-related problems are particularly prevalent. The intent is to encourage governments to implement more effective nuclear export control systems that meet the challenges of the 21st century.« less
75 FR 63165 - Air University Board of Visitors Meeting
Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-14
... advice and recommendations on matters pertaining to the educational, doctrinal, and research policies and... initiatives of Air University educational programs. Additionally, four working groups will meet to discuss issues relating to academic affairs; research; future learning and technology; and institutional...
76 FR 62787 - Air University Board of Visitors Meeting
Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-11
... recommendations on matters pertaining to the educational, doctrinal, and research policies and activities of Air... of Air University educational programs. Additionally, four subcommittees will meet to discuss issues relating to academic affairs; research; future learning and technology; and institutional advancement...
NASA Technical Reports Server (NTRS)
Buden, David
1992-01-01
An overview of space nuclear energy technologies is presented. The development and characteristics of radioisotope thermoelectric generators (RTG's) and space nuclear power reactors are discussed. In addition, the policy and issues related to public safety and the use of nuclear power sources in space are addressed.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-13
... Swaps g. Other Issues Related to Security-Based Swap Submissions h. Additional Comments 2. Prevention of... clearing and exchange trading due to individual business needs of certain users. Those users should retain...
DOE Office of Scientific and Technical Information (OSTI.GOV)
None, None
2004-02-28
The Department of Energy (Department) submits an Annual Report to Congress each year detailing the Department’s activities relating to the Defense Nuclear Facilities Safety Board (Board), which provides advice and recommendations to the Secretary of Energy (Secretary) regarding public health and safety issues at the Department’s defense nuclear facilities. In 2003, the Department continued ongoing activities to resolve issues identified by the Board in formal recommendations and correspondence, staff issue reports pertaining to Department facilities, and public meetings and briefings. Additionally, the Department is implementing several key safety initiatives to address and prevent safety issues: safety culture and review ofmore » the Columbia accident investigation; risk reduction through stabilization of excess nuclear materials; the Facility Representative Program; independent oversight and performance assurance; the Federal Technical Capability Program (FTCP); executive safety initiatives; and quality assurance activities. The following summarizes the key activities addressed in this Annual Report.« less
NASA Technical Reports Server (NTRS)
Wieland, P. O.; Roman, M. C.; Miller, L.
2007-01-01
On board the International Space Station, heat generated by the crew and equipment is removed by the internal active thermal control system to maintain a comfortable working environment and prevent equipment overheating. Test facilities simulating the internal active thermal control system (IATCS) were constructed at the Marshall Space Flight Center as part of the sustaining engineering activities to address concerns related to operational issues, equipment capability, and reliability. A full-scale functional simulator of the Destiny lab module IATCS was constructed and activated prior to launch of Destiny in 2001. This facility simulates the flow and thermal characteristics of the flight system and has a similar control interface. A subscale simulator was built, and activated in 2000, with special attention to materials and proportions of wetted surfaces to address issues related to changes in fluid chemistry, material corrosion, and microbial activity. The flight issues that have arisen and the tests performed using the simulator facilities are discussed in detail. In addition, other test facilities at the MSFC have been used to perform specific tests related to IATCS issues. Future testing is discussed as well as potential modifications to the simulators to enhance their utility.
Land cover, land use changes and air pollution in Asia: a synthesis
NASA Astrophysics Data System (ADS)
Vadrevu, Krishna; Ohara, Toshimasa; Justice, Chris
2017-12-01
A better understanding of land cover/land use changes (LCLUC) and their interactions with the atmospheric environment is essential for the sustainable management of natural resources, environmental protection, air quality, agricultural planning and food security. The 15 papers published in this focus issue showcase a variety of studies relating to drivers and impacts of LCLUC and air pollution in different South/Southeast Asian (S/SEA) countries. This synthesis article, in addition to giving context to the articles in this focus issue, also reviews the broad linkages between population, LCLUC and air pollution. Additionally, we identify knowledge gaps and research priorities that are essential in addressing air pollution issues in the region. We conclude that for effective pollution mitigation in S/SEA countries, quantifying drivers, sources and impacts of pollution need a thorough data analysis through ground-based instrumentation, models and integrated research approaches. We also stress the need for the development of sustainable technologies and strengthening the scientific and resource management communities through capacity building and training activities to address air pollution issues in S/SEA countries.
Code of Federal Regulations, 2011 CFR
2011-04-01
... regulations; deceptive use of a color additive for which a regulation has issued. 71.22 Section 71.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE...; deceptive use of a color additive for which a regulation has issued. The Commissioner shall refuse to issue...
ERIC Educational Resources Information Center
Jurowski, Kamil; Krzeczkowska, Malgorzata Krystyna; Jurowska, Anna
2015-01-01
The concept of oxidation state (or oxidation number) and related issues have always been difficult for students. In addition, there are misunderstandings and obscurities, which can cause improper balancing of the chemical equations (mostly in organic reactions). In particular, these problems are related to determination of the oxidation state of…
Singer, Susanne; Husson, Olga; Tomaszewska, Iwona M; Locati, Laura D; Kiyota, Naomi; Scheidemann-Wesp, Ulrike; Hofmeister, Dirk; Winterbotham, Melanie; Brannan, Christine; Araújo, Cláudia; Gamper, Eva M; Kulis, Dagmara; Rimmele, Harald; Andry, Guy; Licitra, Lisa
2016-11-01
The objectives of this study were to determine quality of life (QoL) issues that are relevant to thyroid cancer patients cross-culturally, and to identify those with highest relevance to them in addition to the more general issues covered by the core European Organisation for Research and Treatment of Cancer QoL questionnaire (EORTC QLQ-C30). A systematic literature search provided a list of potentially relevant QoL issues to supplement the core questionnaire EORTC QLQ-C30, which is widely used in research and in care and addresses QoL issues relevant to all groups of cancer patients. A panel of experts revised this list, and thyroid cancer patients rated the issues regarding their relevance for QoL by selecting the 25 issues that they would include in a thyroid cancer-specific QoL module. The literature search and expert discussion provided a list of 71 QoL issues that was rated by thyroid cancer patients (n = 110) from seven countries. All issues were of high priority to at least some of the patients. The most frequently selected issues were sudden attacks of tiredness, exhaustion, quality of sleep, employment, social support, fear of cancer progression, fear of second operation, difficulties swallowing, and globus sensation. Thyroid cancer patients cross-culturally rate fatigue-related issues as highly important for their QoL, calling for increased efforts to find successful treatments for this problem. Vocational rehabilitation is also highly relevant for them and should therefore be an important aim of multidisciplinary care. The third important area of concern is psychological issues, especially fear of progression and of additional treatments.
2012-03-01
Differences between gasoline fuel and biobutanol fuel including the effects of temperature Safety-related and health issues including safety...where engine-operating parameters such as fuel consumption , performance, and emissions are monitored under controlled conditions, with the addition...7 3.3 Power and Fuel Consumption
ERIC Educational Resources Information Center
Online-Offline, 2000
2000-01-01
This theme issue guides teachers and students to annotated listings of Web sites, CD-ROMs and computer software, videos, books, and additional resources that deal with topics related to rights and responsibilities. Sidebar features discuss animal rights, handling money responsibly, and taking responsibility for the environment. (Contains Three…
Colostomy Irrigation: Issues Most Important to Wound, Ostomy and Continence Nurses.
Tallman, Nancy J; Cobb, Martha D; Grant, Marcia; Wendel, Christopher S; Colwell, Janice; Ercolano, Elizabeth; Krouse, Robert
2015-01-01
The purpose of this study was to describe issues that WOC nurses find most important related to colostomy irrigation (CI). This is an additional analysis of a study focusing on qualitative responses to a survey querying WOC nurses about CI practices. The target population was members of the Wound, Ostomy and Continence Nurses Society. Of the 985 nurses who responded to the survey, 338 (34.3%) answered the optional open-ended question asking for additional comments. A 1-time online survey was conducted. In addition to demographic, educational information, and forced-choice questions about CI, an open-ended question asked for any additional comments about their experience with irrigation and WOC practice. Content analysis was used to identify common themes identified by WOC nurses. Three hundred thirty-eight out of 985 WOC nurses (34.3%) answered the optional open-ended question asking for additional comments; analysis for this study is based on these responses. WOC nurses who responded to the open-ended question had similar characteristics to those who responded to the entire survey but were significantly more experienced (15.1 vs 11.0 years; P < .001). Multiple themes were identified that were related to forced-choice questions in the survey, such as equipment, lack of teaching time, and increased control, while several new themes emerged, including age-related recommendations, economic/ecologic benefits, cultural implications, and misconceptions of CI. Many WOC nurses feel that CI is a valued modality of ostomy care and should be reestablished, although dissenting opinions were expressed. Additional research to increase the evidence base for this procedure is needed. New opportunities to educate WOC nurses and other healthcare professionals and teach eligible patients irrigation techniques are recommended.
Legal and Ethical Issues Regarding Social Media and Pharmacy Education
Fink, Joseph L.
2010-01-01
Widespread use of social media applications like Facebook, YouTube, and Twitter has introduced new complexities to the legal and ethical environment of higher education. Social communications have traditionally been considered private; however, now that much of this information is published online to the public, more insight is available to students' attitudes, opinions, and character. Pharmacy educators and administrators may struggle with the myriad of ethical and legal issues pertaining to social media communications and relationships with and among students. This article seeks to clarify some of these issues with a review of the legal facets and pertinent court cases related to social media. In addition, 5 core ethical issues are identified and discussed. The article concludes with recommendations for pharmacy educators with regard to preparing for and addressing potential legal issues pertaining to social media. PMID:21436925
Legal and ethical issues regarding social media and pharmacy education.
Cain, Jeff; Fink, Joseph L
2010-12-15
Widespread use of social media applications like Facebook, YouTube, and Twitter has introduced new complexities to the legal and ethical environment of higher education. Social communications have traditionally been considered private; however, now that much of this information is published online to the public, more insight is available to students' attitudes, opinions, and character. Pharmacy educators and administrators may struggle with the myriad of ethical and legal issues pertaining to social media communications and relationships with and among students. This article seeks to clarify some of these issues with a review of the legal facets and pertinent court cases related to social media. In addition, 5 core ethical issues are identified and discussed. The article concludes with recommendations for pharmacy educators with regard to preparing for and addressing potential legal issues pertaining to social media.
Murrow, J J; Coulter, R L; Coulter, M K
2000-01-01
The area of health care has been called the most important political issue of the 1990s. Attitudes toward health care reform, increasing health costs, and defensive medical practices have been examined in the public press and by academicians. In addition, a substantial amount of research has been directed toward the improvement of individual personal health due to changes in personal health-related habits and behaviors. To date, there are relatively few studies which have attempted to examine the political tendencies of a nationwide sample of respondents as they relate to personal health-related beliefs and behaviors. This article explores the consumer's views on critical questions relating to health orientations and political tendencies. The results indicate a divergence between the political orientations of respondents and their beliefs and behaviors associated with health and wellness. Implications for policy-makers are discussed.
Additive Manufacturing: Ensuring Quality for Spacecraft Applications
NASA Technical Reports Server (NTRS)
Swanson, Theodore; Stephenson, Timothy
2014-01-01
Reliable manufacturing requires that material properties and fabrication processes be well defined in order to insure that the manufactured parts meet specified requirements. While this issue is now relatively straightforward for traditional processes such as subtractive manufacturing and injection molding, this capability is still evolving for AM products. Hence, one of the principal challenges within AM is in qualifying and verifying source material properties and process control. This issue is particularly critical for applications in harsh environments and demanding applications, such as spacecraft.
Issues and Theoretical Constructs Regarding Parent Education for Autism Spectrum Disorders
Koegel, Lynn K.; Koegel, Robert L.; Ence, Whitney A.
2013-01-01
Participation of parents of children with autism is commonplace in most comprehensive intervention programs, yet, there is limited research relating to the best practices in this area. This article provides an overview of parent education programs for young children with autism and details data-driven procedures which are associated with improved parent and child outcomes. In addition, we provide a troubleshooting guide based on the literature for professionals regarding a variety of complex issues which may arise during parent education. PMID:21336525
Voltage Impacts of Utility-Scale Distributed Wind
DOE Office of Scientific and Technical Information (OSTI.GOV)
Allen, A.
2014-09-01
Although most utility-scale wind turbines in the United States are added at the transmission level in large wind power plants, distributed wind power offers an alternative that could increase the overall wind power penetration without the need for additional transmission. This report examines the distribution feeder-level voltage issues that can arise when adding utility-scale wind turbines to the distribution system. Four of the Pacific Northwest National Laboratory taxonomy feeders were examined in detail to study the voltage issues associated with adding wind turbines at different distances from the sub-station. General rules relating feeder resistance up to the point of turbinemore » interconnection to the expected maximum voltage change levels were developed. Additional analysis examined line and transformer overvoltage conditions.« less
Space, geophysical research related to Latin America - Part 2
NASA Astrophysics Data System (ADS)
Mendoza, Blanca; Shea, M. A.
2016-11-01
For the last 25 years, every two to three years the Conferencia Latinoamericana de Geofísica Espacial (COLAGE) is held in one of the Latin American countries for the purpose of promoting scientific exchange among scientists of the region and to encourage continued research that is unique to this area of the world. At the more recent conference, the community realized that many individuals both within and outside Latin America have contributed greatly to the understanding of the space sciences in this area of the world. It was therefore decided to assemble a Special Issue Space and Geophysical Physics related to Latin America, presenting recent results and where submissions would be accepted from the world wide community of scientists involved in research appropriate to Latin America. Because of the large number of submissions, these papers have been printed in two separate issues. The first issue was published in Advances in Space Research, Vol. 57, number 6 and contained 15 papers. This is the second issue and contains 25 additional papers. These papers show the wide variety of research, both theoretical and applied, that is currently being developed or related to space and geophysical sciences in the Sub-Continent.
Radiation safety issues related to radiolabeled antibodies. [Contains glossary
DOE Office of Scientific and Technical Information (OSTI.GOV)
Barber, D.E.; Baum, J.W.; Meinhold, C. B.
1991-03-01
Techniques related to the use of radiolabeled antibodies in humans are reviewed and evaluated in this report. It is intended as an informational resource for the US Nuclear Regulatory Commission (NRC) and NRC licensees. Descriptions of techniques and health and safety issues are provided. Principal methods for labeling antibodies are summarized to help identify related radiation safety problems in the preparation of dosages for administration to patients. The descriptions are derived from an extensive literature review and consultations with experts in the field. A glossary of terms and acronyms is also included. An assessment was made of the extent ofmore » the involvement of organizations (other than the NRC) with safety issues related to radiolabeled antibodies, in order to identify regulatory issues which require attention. Federal regulations and guides were also reviewed for their relevance. A few (but significant) differences between the use of common radiopharmaceuticals and radiolabeled antibodies were observed. The clearance rate of whole, radiolabeled immunoglobulin is somewhat slower than common radiopharmaceuticals, and new methods of administration are being used. New nuclides are being used or considered (e.g., Re-186 and At-211) for labeling antibodies. Some of these nuclides present new dosimetry, instrument calibration, and patient management problems. Subjects related to radiation safety that require additional research are identified. 149 refs., 3 figs., 20 tabs.« less
76 FR 74049 - National Coal Council
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-30
... DEPARTMENT OF ENERGY National Coal Council AGENCY: Office of Fossil Energy, Department of Energy..., notice is hereby given that the National Coal Council will be renewed for a two-year period beginning... general policy matters relating to coal issues. Additionally, the renewal of the Council has been...
USDA-ARS?s Scientific Manuscript database
Chemical and microbiological contamination of food during processing and preservation can result in foodborne illness outbreaks and food poisoning. Chemical contaminations can occur through exposure of foods to illegal additives, pesticides and fertilizer residues, toxic compounds formed by microbes...
A Biopsychosocial Theory of Infertility.
ERIC Educational Resources Information Center
Gerrity, Deborah A.
2001-01-01
Briefly reviews the literature on infertility and its emotional, physical, existential, and relational effects on individuals, couples, and families. Life crisis and biopsychosocial theories are discussed as they apply to persons struggling with infertility issues. In addition, stage models derived from a biopsychosocial perspective are presented.…
Reisen, Carol A; Brooks, Kelly D; Zea, Maria Cecilia; Poppen, Paul J; Bianchi, Fernanda T
2013-04-01
The current study investigated a methodological question of whether traditional, additive, quantitative data can be used to address intersectional issues, and illustrated such an approach with a sample of 301 HIV-positive, Latino gay men in the United States. Participants were surveyed using A-CASI. Hierarchical logistic set regression investigated the role of sets of variables reflecting demographic characteristics, gender nonconformity, and gay and ethnic discrimination in relation to depression and gay collective identity. Results showed the discrimination set was related to depression and to gay collective identity, as was gender nonconformity. Follow-up logistic regression showed that both types of discrimination were associated with greater depression, but gender nonconformity was not. Gay discrimination and gender nonconformity were positively associated with gay collective identity, whereas ethnic discrimination was negatively associated. Results are discussed in terms of the use of traditional quantitative data as a potential means of understanding intersectional issues, as well as of contributing to knowledge about individuals facing multiple structural inequalities.
Timing of translation in cross-language qualitative research.
Santos, Hudson P O; Black, Amanda M; Sandelowski, Margarete
2015-01-01
Although there is increased understanding of language barriers in cross-language studies, the point at which language transformation processes are applied in research is inconsistently reported, or treated as a minor issue. Differences in translation timeframes raise methodological issues related to the material to be translated, as well as for the process of data analysis and interpretation. In this article we address methodological issues related to the timing of translation from Portuguese to English in two international cross-language collaborative research studies involving researchers from Brazil, Canada, and the United States. One study entailed late-phase translation of a research report, whereas the other study involved early phase translation of interview data. The timing of translation in interaction with the object of translation should be considered, in addition to the language, cultural, subject matter, and methodological competencies of research team members. © The Author(s) 2014.
Another decade of social scientific work on sex work: a review of research 1990-2000.
Vanwesenbeeck, I
2001-01-01
The international, psychological and sociological research literature on prostitution from 1990 through 2000 is reviewed. The stage is set by scanning topics and perspectives in earlier writings. Then the research is discussed under the following headings: (a) HIV related research (HIV prevalence studies, factors in condom use, and prevention program evaluation); (b) workers' background and motivational issues (early victimization and connected factors, economic motives and connected factors); (c) work related issues (working routines, risks and stresses, and managing risk, work and identity); (d) research on clients, and (e) issues related to social and legal status. The literature is still much more about sex than it is about work. In addition, although an increasing number of authors have criticized the dominance of a deviance perspective over work perspectives on prostitution, the literature still reveals many features of stigmatization. For instance, the wrongs associated with sex work are all too often attributed to the nature of sex work itself instead of to the stigma attached to it or to specific negative circumstances. Likewise, the association between prostitution and negative features (in particular HIV and early victimization) is overwhelming, despite evidence that, for large groups of sex workers, these issues are of limited relevance. Generally, writers fail to adequately differentiate among types of sex workers. In particular, in relation to issues of health and well-being, differentiation among sex workers on the basis of specific features of their working situation (e.g., contexts, routines, relations, conditions) has hardly been studied and is recommended for the future.
EPA guidance on improving the image of psychiatry.
Möller-Leimkühler, A M; Möller, H-J; Maier, W; Gaebel, W; Falkai, P
2016-03-01
This paper explores causes, explanations and consequences of the negative image of psychiatry and develops recommendations for improvement. It is primarily based on a WPA guidance paper on how to combat the stigmatization of psychiatry and psychiatrists and a Medline search on related publications since 2010. Furthermore, focussing on potential causes and explanations, the authors performed a selective literature search regarding additional image-related issues such as mental health literacy and diagnostic and treatment issues. Underestimation of psychiatry results from both unjustified prejudices of the general public, mass media and healthcare professionals and psychiatry's own unfavourable coping with external and internal concerns. Issues related to unjustified devaluation of psychiatry include overestimation of coercion, associative stigma, lack of public knowledge, need to simplify complex mental issues, problem of the continuum between normality and psychopathology, competition with medical and non-medical disciplines and psychopharmacological treatment. Issues related to psychiatry's own contribution to being underestimated include lack of a clear professional identity, lack of biomarkers supporting clinical diagnoses, limited consensus about best treatment options, lack of collaboration with other medical disciplines and low recruitment rates among medical students. Recommendations are proposed for creating and representing a positive self-concept with different components. The negative image of psychiatry is not only due to unfavourable communication with the media, but is basically a problem of self-conceptualization. Much can be improved. However, psychiatry will remain a profession with an exceptional position among the medical disciplines, which should be seen as its specific strength.
Progression in Ethical Reasoning When Addressing Socio-scientific Issues in Biotechnology
NASA Astrophysics Data System (ADS)
Berne, Birgitta
2014-11-01
This article reports on the outcomes of an intervention in a Swedish school in which the author, a teacher-researcher, sought to develop students' (14-15 years old) ethical reasoning in science through the use of peer discussions about socio-scientific issues. Prior to the student discussions various prompts were used to highlight different aspects of the issues. In addition, students were given time to search for further information themselves. Analysis of students' written arguments, from the beginning of the intervention and afterwards, suggests that many students seem to be moving away from their use of everyday language towards using scientific concepts in their arguments. In addition, they moved from considering cloning and 'designer babies' solely in terms of the present to considering them in terms of the future. Furthermore, the students started to approach the issues in additional ways using not only consequentialism but also the approaches of virtue ethics, and rights and duties. Students' progression in ethical reasoning could be related to the characteristics of the interactions in peer discussions as students who critically and constructively argued with each other's ideas, and challenged each other's claims, made progress in more aspects of ethical reasoning than students merely using cumulative talk. As such, the work provides valuable indications for the importance of introducing peer discussions and debates about SSIs in connection to biotechnology into the teaching of science in schools.
Maddock, Jay E; McGurk, Meghan; Lee, Thomas
2015-01-01
Legislation and regulation at the state and local level can often have a greater impact on the public's health than individual-based approaches. Elected and appointed officials have an essential role in protecting and improving public health. Despite this important role, little systematic research has been done to assess the relative importance of public health issues compared to other policy issues in times of economic hardship. This study assessed attitudes of elected and appointed decision makers in Hawaii in 2007 and 2013 to determine if priorities differed before and after the economic recession. Elected and appointed state and county officials were mailed surveys at both time points. Respondents rated the importance of 23 specified problems, of which 9 asked about specific public health issues. The survey was completed by 126 (70.4%) respondents in 2007 and 117 (60.9%) in 2013. Among the public health issues, five saw significant mean decreases. These variables included climate change, pedestrian safety, government response to natural disasters, access to healthcare, and pandemic influenza. Obesity was the only public health issue to increase in importance across the two time points. In terms of relative ranking across the time points, only drug abuse and obesity were among the top 10 priorities. Lack of public health training, pandemic influenza, and government response to natural disasters were among the bottom five priorities. After the economic recession, many public health issues have a lower priority among Hawaii's policy makers than before the downturn. Additional education and advocacy is needed to keep public health issues on the minds of decision makers during tough economic times.
Meta-Analyses and Orthodontic Evidence-Based Clinical Practice in the 21st Century
Papadopoulos, Moschos A.
2010-01-01
Introduction: Aim of this systematic review was to assess the orthodontic related issues which currently provide the best evidence as documented by meta-analyses, by critically evaluating and discussing the methodology used in these studies. Material and Methods: Several electronic databases were searched and handsearching was also performed in order to identify the corresponding meta-analyses investigating orthodontic related subjects. In total, 197 studies were retrieved initially. After applying specific inclusion and exclusion criteria, 27 articles were identified as meta-analyses treating orthodontic-related subjects. Results: Many of these 27 papers presented sufficient quality and followed appropriate meta-analytic approaches to quantitatively synthesize data and presented adequately supported evidence. However, the methodology used in some of them presented weaknesses, limitations or deficiencies. Consequently, the topics in orthodontics which currently provide the best evidence, include some issues related to Class II or Class III treatment, treatment of transverse problems, external apical root resorption, dental anomalies, such as congenital missing teeth and tooth transposition, frequency of severe occlusal problems, nickel hypersensitivity, obstructive sleep apnea syndrome, and computer-assisted learning in orthodontic education. Conclusions: Only a few orthodontic related issues have been so far investigated by means of MAs. In addition, for some of these issues investigated in the corresponding MAs no definite conclusions could be drawn, due to significant methodological deficiencies of these studies. According to this investigation, it can be concluded that at the begin of the 21st century there is evidence for only a few orthodontic related issues as documented by meta-analyses, and more well-conducted high quality research studies are needed to produce strong evidence in order to support evidence-based clinical practice in orthodontics. PMID:21673839
NASA Technical Reports Server (NTRS)
Goseva-Popstojanova, Katerina; Tyo, Jacob P.; Sizemore, Brian
2017-01-01
NASA develops, runs, and maintains software systems for which security is of vital importance. Therefore, it is becoming an imperative to develop secure systems and extend the current software assurance capabilities to cover information assurance and cybersecurity concerns of NASA missions. The results presented in this report are based on the information provided in the issue tracking systems of one ground mission and one flight mission. The extracted data were used to create three datasets: Ground mission IVV issues, Flight mission IVV issues, and Flight mission Developers issues. In each dataset, we identified the software bugs that are security related and classified them in specific security classes. This information was then used to create the security vulnerability profiles (i.e., to determine how, why, where, and when the security vulnerabilities were introduced) and explore the existence of common trends. The main findings of our work include:- Code related security issues dominated both the Ground and Flight mission IVV security issues, with 95 and 92, respectively. Therefore, enforcing secure coding practices and verification and validation focused on coding errors would be cost effective ways to improve mission's security. (Flight mission Developers issues dataset did not contain data in the Issue Category.)- In both the Ground and Flight mission IVV issues datasets, the majority of security issues (i.e., 91 and 85, respectively) were introduced in the Implementation phase. In most cases, the phase in which the issues were found was the same as the phase in which they were introduced. The most security related issues of the Flight mission Developers issues dataset were found during Code Implementation, Build Integration, and Build Verification; the data on the phase in which these issues were introduced were not available for this dataset.- The location of security related issues, as the location of software issues in general, followed the Pareto principle. Specifically, for all three datasets, from 86 to 88 the security related issues were located in two to four subsystems.- The severity levels of most security issues were moderate, in all three datasets.- Out of 21 primary security classes, five dominated: Exception Management, Memory Access, Other, Risky Values, and Unused Entities. Together, these classes contributed from around 80 to 90 of all security issues in each dataset. This again proves the Pareto principle of uneven distribution of security issues, in this case across CWE classes, and supports the fact that addressing these dominant security classes provides the most cost efficient way to improve missions' security. The findings presented in this report uncovered the security vulnerability profiles and identified the common trends and dominant classes of security issues, which in turn can be used to select the most efficient secure design and coding best practices compiled by the part of the SARP project team associated with the NASA's Johnson Space Center. In addition, these findings provide valuable input to the NASA IVV initiative aimed at identification of the two 25 CWEs of ground and flight missions.
O'Connor, Jim E.; Wallick, J. Rose; Sobieszczyk, Steven; Cannon, Charles; Anderson, Scott W.
2009-01-01
This report addresses physical channel issues related to instream gravel mining on the Umpqua River and its two primary tributaries, the North and South Umpqua Rivers. This analysis constitutes a “Phase I” investigation, as designated by an interagency team cochaired by the U.S. Army Corps of Engineers, Portland District, and the Oregon Department of State Lands to address instream gravel mining issues across Oregon. Phase I analyses rely primarily on existing datasets and cursory analysis to determine the vertical stability of a channel to ascertain whether a particular river channel is aggrading, degrading, or at equilibrium. Additionally, a Phase I analysis identifies other critical issues or questions pertinent to physical channel conditions that may be related to instream gravel mining activities.This analysis can support agency permitting decisions as well as possibly indicating the need for additional studies. This specific analysis focuses on the mainstem Umpqua River from the Pacific Ocean at River Mile (RM) 0 to the confluence of the North and South Umpqua Rivers (at RM 111.8), as well as the lower 29 mi of the North Umpqua River and the lower 80 mi of the South Umpqua River (fig. 1). It is within these reaches where mining of gravel bars for aggregate has been most prevalent.
Managing the transcription revolution. Industry forces shape future of field.
Faulkner, Scott D
2003-01-01
You may be struggling with contract issues with a vendor. Or maybe you're contemplating the pros and cons of working with outsource, at-home, or overseas transcriptionists. It's a fact: if transcription processes aren't working efficiently, the entire HIM department may be adversely affected. Factor in additional concerns such as data capture for electronic health records, compliance, and patient safety, and the importance of ensuring quality and cost-efficient transcription becomes even more apparent. To help you answer some of these questions, the Journal of AHIMA is launching a four-part series dedicated to transcription issues from the HIM professional's point of view. In this issue, we begin with MTIA president Scott Faulkner's overview of the industry and where it's going next. In upcoming issues, other experts will look at controlling cost and monitoring quality, navigating new technologies, and dealing with contract-related issues.
78 FR 71592 - National Coal Council
Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-29
... DEPARTMENT OF ENERGY National Coal Council AGENCY: Department of Energy, Office of Fossil Energy..., notice is hereby given that the National Coal Council (NCC) will be renewed for a two-year period. The... matters relating to coal issues. Additionally, the renewal of the National Coal Council has been...
77 FR 58982 - New England Fishery Management Council; Public Meeting
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-25
... allowed into the Georges Bank access areas. The Committee may also develop options for additional sub-ACLs... may be incorporated into the framework, such as issues related to Georges Bank yellowtail flounder.... Special Accommodations This meeting is physically accessible to people with disabilities. Requests for...
Publishing with Undergraduates: Some Further Observations
ERIC Educational Resources Information Center
Griffiths, Mark
2015-01-01
This paper provides some additional observations on publishing with undergraduates following the short paper by Hartley (2014) in a previous issue of "Psychology Teaching Review." This paper's main focus relates to how students can develop as scholars by lecturers actively encouraging students to disseminate their written and oral…
The Relationships of Intergroup Ideologies to Ethnic Prejudice: A Meta-Analysis.
Whitley, Bernard E; Webster, Gregory D
2018-04-01
This meta-analysis summarizes the results of research on the relationships of majority group members' endorsement of assimilation, colorblindness, multiculturalism, and the relative relationships of colorblindness and multiculturalism to ethnic prejudice. Random effects analyses found that assimilation was positively related to explicit prejudice ( g. = 0.80), multiculturalism was negatively related to both explicit ( g. = -0.26) and implicit prejudice ( g. = -0.19), and colorblindness was negatively related to explicit prejudice ( g. = -0.07). Multiculturalism was more closely associated with low prejudice than colorblindness ( g. = 0.15). Effect sizes varied as a function of methodology (experimental vs. correlational), country in which research was conducted (United States vs. other countries), and, in experimental studies of multiculturalism, type of prime used (abstract vs. concrete). Discussion points include methodological issues, groups used as targets of prejudice, national diversity norms, additional issues raised in the studies reviewed, and directions for future research.
Mohr, Philip; Golley, Sinéad
2016-01-25
This study examined community responses to use of genetically modified (GM) content in food in the context of responses to familiar food additives by testing an empirically and theoretically derived model of the predictors of responses to both GM content and food integrity issues generally. A nationwide sample of 849 adults, selected at random from the Australian Electoral Roll, responded to a postal Food and Health Survey. Structural equation modelling analyses confirmed that ratings of general concern about food integrity (related to the presence of preservatives and other additives) strongly predicted negativity towards GM content. Concern about food integrity was, in turn, predicted by environmental concern and health engagement. In addition, both concern about food integrity generally and responses to GM content specifically were weakly predicted by attitudes to benefits of science and an intuitive (i.e., emotionally-based) reasoning style. Data from a follow-up survey conducted under the same conditions (N=1184) revealed that ratings of concern were significantly lower for use of genetic engineering in food than for four other common food integrity issues examined. Whereas the question of community responses to GM is often treated as a special issue, these findings support the conclusion that responses to the concept of GM content in food in Australia are substantially a specific instance of a general sensitivity towards the integrity of the food supply. They indicate that the origins of responses to GM content may be largely indistinguishable from those of general responses to preservatives and other common food additives. Copyright © 2015 Elsevier B.V. All rights reserved.
Design and analysis issues of integrated control systems for high-speed civil transports
NASA Technical Reports Server (NTRS)
Mccarty, Craig A.; Feather, John B.; Dykman, John R.; Page, Mark A.; Hodgkinson, John
1992-01-01
A study was conducted to identify, rank, and define development plans for the critical guidance and control design and analysis issues as related to economically viable and environmentally acceptable high-speed civil transport. The issues were identified in a multistep process. First, pertinent literature on supersonic cruise aircraft was reviewed, and experts were consulted to establish the fundamental characteristics and problems inherent to supersonic cruise aircraft. Next, the advanced technologies and strategies being pursued for the high-speed civil transport were considered to determine any additional unique control problems the transport may have. Finally, existing technologies and methods were examined to determine their capabilities for the design and analysis of high-speed civil transport control systems and to identify the shortcomings and issues. Three priority levels - mandatory, highly beneficial, and desirable - were established. Within each of these levels, the issues were further ranked. Technology development plans for each issue were defined. Each plan contains a task breakdown and schedule.
20 CFR 410.637 - Hearing on new issues.
Code of Federal Regulations, 2011 CFR
2011-04-01
..., TITLE IV-BLACK LUNG BENEFITS (1969- ) Determinations of Disability, Other Determinations, Administrative... party or his own motion, in addition to the matters brought before him by the request for hearing, give... or a related matter, and whether arising subsequent to the request for hearing, which may affect the...
20 CFR 410.637 - Hearing on new issues.
Code of Federal Regulations, 2010 CFR
2010-04-01
..., TITLE IV-BLACK LUNG BENEFITS (1969- ) Determinations of Disability, Other Determinations, Administrative... party or his own motion, in addition to the matters brought before him by the request for hearing, give... or a related matter, and whether arising subsequent to the request for hearing, which may affect the...
29 CFR 515.5 - Additional requirements.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS UTILIZATION... such supplements to or provisions thereof as may be issued from time to time by the Division or the... of the Division and the Secretary of Labor may at any time, upon notifying the State agency, make...
29 CFR 515.5 - Additional requirements.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS UTILIZATION... such supplements to or provisions thereof as may be issued from time to time by the Division or the... of the Division and the Secretary of Labor may at any time, upon notifying the State agency, make...
Understanding the Implications of HIV Disease in Women.
ERIC Educational Resources Information Center
Carney, Jamie S.
2003-01-01
In this article, counselors are urged to become knowledgeable about the many issues and stressors that women with HIV disease face. This article provides an overview of such concerns, including disease characteristics, progression, and symptoms. In addition, psychological, social, and relationship concerns are identified in relation to parenting,…
Accounting Issues: An Essay Series Part III--Inventory
ERIC Educational Resources Information Center
Laux, Judy
2007-01-01
The third in a series of theoretical essays intended to supplement the introductory financial accounting course, this article is dedicated to the treatment of inventory and its related conceptual connections. In addition, this paper addresses inventory measurement dilemmas, describes scandalous accounting episodes that have made the headlines, and…
Confidentiality Revisited: A Response to Manhal-Baugus (1996).
ERIC Educational Resources Information Center
Doyle, Kevin
1998-01-01
Reviews the issues relating to confidentiality raised by Manhal-Baugus (1996), identifies problem areas from the 1996 article, and offers additional information about confidentiality not included in the article. Chemical dependency counselors are urged to consider the federal law covering confidentiality of alcohol- and drug-abuse patient records…
Autism Spectrum Disorders and Implications for Teachers
ERIC Educational Resources Information Center
Echaniz, Crystal; Cronin, Kathleen A.
2014-01-01
This paper reviews characteristics of autism spectrum disorders (ASD), possible causes of ASD, current demographic information, the effects on the individual with ASD and the family, as well as diversity and multicultural issues related to autism. Additionally, the paper provides pertinent information about students with ASD for both general…
75 FR 53015 - Public Listening Session
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-30
... commercial motor vehicles (CMVs) and saving lives. In carrying out its safety mandate to reduce crashes.... Following are some of the key issues that the Agency hopes public comments will address. In addition to.../mission of improving the safety of commercial motor vehicles (CMV) and saving lives as it relates to some...
ERIC Educational Resources Information Center
Liao, Jiadong; Han, Jinghe
2012-01-01
Information behaviour is a pertinent practice throughout students' research work. However, research students, particularly those with English as an additional language, experienced challenges and complications when studying in a western university. Issues relating to their information behaviour during the research process has largely been…
Navigating the Measurement and Monitoring Maze
ERIC Educational Resources Information Center
Brigham, Frederick J.; Berkeley, Sheri; Walker, Erin
2012-01-01
Assessment of students with disabilities is a critical component of special education. In addition to the complexity of assessment (e.g., high-stakes assessments, progress monitoring, diagnosis), the issue is complicated further by the use of acronyms. This can make both explaining and understanding important information related to students very…
Factors Relating to Student Grade Obsession: A Quantitative Correlational Study
ERIC Educational Resources Information Center
Thomas, Jacqueline
2011-01-01
The intense focus of students on grades attained in academia reflects a contemporary issue in higher education. The internal pressure that students experience regarding academics fuels student grade obsession. Researchers suggest that in addition to internal pressure, financial anxiety, the need to receive academic recognition and parental…
Interim Evaluation of the National Literacy Program. Final Report
ERIC Educational Resources Information Center
Human Resources and Social Development Canada, 2007
2007-01-01
The evaluation examined issues related to: (1) Rationale and Relevance; (2) Implementation; and (3) Success. In addition, the interim evaluation was intended to: (1) Determine whether sufficient data was being collected to inform the summative evaluation and identify opportunities for improvement to fill any potential gaps; (2) Assess whether the…
75 FR 48929 - Notice of Meeting of the Agricultural Air Quality Task Force
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-12
... Agricultural Air Quality Task Force AGENCY: Natural Resources Conservation Service (NRCS), United States... Triangle Park, North Carolina 27711; (919) 541-5400. The Agricultural Air Quality Task Force (AAQTF) will meet to continue discussions on air quality issues relating to agriculture. Additionally, the Livestock...
Kansas Center for Research in Early Childhood Education Annual Report, FY 1973.
ERIC Educational Resources Information Center
Horowitz, Frances D.
This monograph is a collection of papers describing a series of loosely related studies of visual attention, auditory stimulation, and language discrimination in young infants. Titles include: (1) Infant Attention and Discrimination: Methodological and Substantive Issues; (2) The Addition of Auditory Stimulation (Music) and an Interspersed…
Sex Education for Deaf-Blind Youths and Adults.
ERIC Educational Resources Information Center
Ingraham, Cynthia L.; Vernon, McCay; Clemente, Brenda; Olney, Linda
2000-01-01
This article describes a model sex education program developed for youths and adults who are deafblind by the Helen Keller National Center for Deaf-Blind Youths and Adults. In addition, it also discusses major related issues and presents general recommendations and a resource for further information. (Contains 11 references.) (Author/CR)
1989-09-01
with increased capital expenditures, improvements in compensation, or additional labor resources or increased nonpersonnel Operation and Maintenance ( O ...facilities. These problems primarily need increased capital expenditures. Another category of problems relates to shortages of supplies, manuals, and other O ...service differ from gross reserve compen- sation because of the following factors: " Federal, state, and FICA taxes " Forgone civilian income - During
Workshop on Countering Space Adaptation with Exercise: Current Issues
NASA Technical Reports Server (NTRS)
Harris, Bernard A. (Editor); Siconolfi, Steven F. (Editor)
1994-01-01
The proceedings represent an update to the problems associated with living and working in space and the possible impact exercise would have on helping reduce risk. The meeting provided a forum for discussions and debates on contemporary issues in exercise science and medicine as they relate to manned space flight with outside investigators. This meeting also afforded an opportunity to introduce the current status of the Exercise Countermeasures Project (ECP) science investigations and inflight hardware and software development. In addition, techniques for physiological monitoring and the development of various microgravity countermeasures were discussed.
A review of nuclear thermal propulsion carbide fuel corrosion and key issues
NASA Technical Reports Server (NTRS)
Pelaccio, Dennis G.; El-Genk, Mohamed S.
1994-01-01
Corrosion (mass loss) of carbide nuclear fuels due to their exposure to hot hydrogen in nuclear thermal propulsion engine systems greatly impacts the performance, thrust-to-weight and life of such systems. This report provides an overview of key issues and processes associated with the corrosion of carbide materials. Additionally, past pertinent development reactor test observations, as well as related experimental work and analysis modeling efforts are reviewed. At the conclusion, recommendations are presented, which provide the foundation for future corrosion modeling and verification efforts.
Emergency Responses and Health Consequences after the Fukushima Accident; Evacuation and Relocation.
Hasegawa, A; Ohira, T; Maeda, M; Yasumura, S; Tanigawa, K
2016-04-01
The Fukushima accident was a compounding disaster following the strong earthquake and huge tsunami. The direct health effects of radiation were relatively well controlled considering the severity of the accident, not only among emergency workers but also residents. Other serious health issues include deaths during evacuation, collapse of the radiation emergency medical system, increased mortality among displaced elderly people and public healthcare issues in Fukushima residents. The Fukushima mental health and lifestyle survey disclosed that the Fukushima accident caused severe psychological distress in the residents from evacuation zones. In addition to psychiatric and mental health problems, there are lifestyle-related problems such as an increase proportion of those overweight, an increased prevalence of hypertension, diabetes mellitus and dyslipidaemia and changes in health-related behaviours among evacuees; all of which may lead to an increased cardiovascular disease risk in the future. The effects of a major nuclear accident on societies are diverse and enduring. The countermeasures should include disaster management, long-term general public health services, mental and psychological care, behavioural and societal support, in addition to efforts to mitigate the health effects attributable to radiation. Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Generalized Bondi-Sachs equations for characteristic formalism of numerical relativity
NASA Astrophysics Data System (ADS)
Cao, Zhoujian; He, Xiaokai
2013-11-01
The Cauchy formalism of numerical relativity has been successfully applied to simulate various dynamical spacetimes without any symmetry assumption. But discovering how to set a mathematically consistent and physically realistic boundary condition is still an open problem for Cauchy formalism. In addition, the numerical truncation error and finite region ambiguity affect the accuracy of gravitational wave form calculation. As to the finite region ambiguity issue, the characteristic extraction method helps much. But it does not solve all of the above issues. Besides the above problems for Cauchy formalism, the computational efficiency is another problem. Although characteristic formalism of numerical relativity suffers the difficulty from caustics in the inner near zone, it has advantages in relation to all of the issues listed above. Cauchy-characteristic matching (CCM) is a possible way to take advantage of characteristic formalism regarding these issues and treat the inner caustics at the same time. CCM has difficulty treating the gauge difference between the Cauchy part and the characteristic part. We propose generalized Bondi-Sachs equations for characteristic formalism for the Cauchy-characteristic matching end. Our proposal gives out a possible same numerical evolution scheme for both the Cauchy part and the characteristic part. And our generalized Bondi-Sachs equations have one adjustable gauge freedom which can be used to relate the gauge used in the Cauchy part. Then these equations can make the Cauchy part and the characteristic part share a consistent gauge condition. So our proposal gives a possible new starting point for Cauchy-characteristic matching.
van Goethem, Anne A J; van Hoof, Anne; van Aken, Marcel A G; Raaijmakers, Quinten A W; Boom, Jan; de Castro, Bram Orobio
2012-06-01
The aim of this study was to explain adolescents' volunteering in terms of their morality and identity and to examine the moderation effect of gender and age in this process. Data were collected among 698 Dutch adolescents aged 12 to 20 (M = 15.19; SD = 1.43). Adolescents' moral reasoning was positively associated with understanding moral issues and thinking about public responsibility towards these issues. In turn, moral understanding, along with being personally committed to act upon moral issues, were positively associated with identity. Extending the number of identity contexts tended to be related to being more likely to volunteer and to more volunteering involvement. Adolescents' identity integration was not related to how likely they were to volunteer, and was negatively related to their volunteering involvement. Clearer effects were found when differentiating between adolescent gender and age groups. Future research could examine this process over time, along with additional factors that may further explain adolescents' volunteering, and examine their age and gender specific effects. Copyright © 2011 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.
Issues related to development of antiepileptogenic therapies.
Pitkänen, Asla; Nehlig, Astrid; Brooks-Kayal, Amy R; Dudek, F Edward; Friedman, Daniel; Galanopoulou, Aristea S; Jensen, Frances E; Kaminski, Rafal M; Kapur, Jaideep; Klitgaard, Henrik; Löscher, Wolfgang; Mody, Istvan; Schmidt, Dieter
2013-08-01
Several preclinical proof-of-concept studies have provided evidence for positive treatment effects on epileptogenesis. However, none of these hypothetical treatments has advanced to the clinic. The experience in other fields of neurology such as stroke, Alzheimer's disease, or amyotrophic lateral sclerosis has indicated several problems in the design of preclinical studies, which likely contribute to failures in translating the positive preclinical data to the clinic. The Working Group on "Issues related to development of antiepileptogenic therapies" of the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) has considered the possible problems that arise when moving from proof-of-concept antiepileptogenesis (AEG) studies to preclinical AEG trials, and eventually to clinical AEG trials. This article summarizes the discussions and provides recommendations on how to design a preclinical AEG monotherapy trial in adult animals. We specifically address study design, animal and model selection, number of studies needed, issues related to administration of the treatment, outcome measures, statistics, and reporting. In addition, we give recommendations for future actions to advance the preclinical AEG testing. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.
Labour migration and the single European market: a synthetic and prospective note.
Ardittis, S
1990-12-01
"The present paper is an attempt to analyse and forecast the following major issues relating to migration in Europe after 1992: (i) the evolution and structure of intra-European flows in the forthcoming single European market; (ii) the integration, after 1992, of established immigrant communities, including ethnic minorities and second generation groups; (iii) future immigration from non-EC member states.... The article explains that, in addition to policy-related mutations inherent in the completion of the internal market, other factors (demographic changes and insufficient enrolment of national graduate students in key disciplines) and issues (emergence of atypical groups such as second generation and Eastern European migrants), are due to generate new patterns and modified interests in European labour migration after 1992." excerpt
Adkins, P C
1980-07-01
The Society of Thoracic Surgeons is the largest organization representing our specialty. At this time, escalating costs of medical care and the public demand for accountability have given rise to a number of issues that must be faced. The Society is in a position to lead the medical profession in addressing many of these issues. We must present a united front for our specialty and resolve problems involving our training programs, manpower, federal regulations regarding medical devices, and the Federal Trade Commission's position on advertising. Additionally, the organization must address the issue of a definition of physician competence as it relates to the certifying and recertifying process. Awareness of these problems by all members of the Society with the opportunity for open discussion is essential. It is vital that The Society of Thoracic Surgeons assume a visible positive position on these issues.
Cardenas, Stephanie A.; Kassem, Layla; Brotman, Melissa A.; Leibenluft, Ellen; McMahon, Francis J.
2016-01-01
Background Neurocognitive deficits are present in bipolar disorder (BD) patients and their unaffected (nonbipolar) relatives, but it is not clear which domains are most often impaired and the extent of the impairment resulting from shared genetic factors. In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives. Method We conducted a systematic review in Web of Science, PubMed/Medline and PsycINFO databases. Results Fifty-one articles assessing cognitive functioning in BD patients (23 studies) and unaffected relatives (28 studies) were examined. Patients and, less so, relatives show impairments in attention, processing speed, verbal learning/memory, and verbal fluency. Conclusion Studies were more likely to find impairment in patients than relatives, suggesting that some neurocognitive deficits may be a result of the illness itself and/or its treatment. However, small sample sizes, differences among relatives studied (e.g., relatedness, diagnostic status, age), and differences in assessment instruments may contribute to inconsistencies in reported neurocognitive performance among relatives. Additional studies addressing these issues are needed. PMID:27502749
Cardenas, Stephanie A; Kassem, Layla; Brotman, Melissa A; Leibenluft, Ellen; McMahon, Francis J
2016-10-01
Neurocognitive deficits are present in bipolar disorder (BD) patients and their unaffected (nonbipolar) relatives, but it is not clear which domains are most often impaired and the extent of the impairment resulting from shared genetic factors. In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives. We conducted a systematic review in Web of Science, PubMed/Medline and PsycINFO databases. Fifty-one articles assessing cognitive functioning in BD patients (23 studies) and unaffected relatives (28 studies) were examined. Patients and, less so, relatives show impairments in attention, processing speed, verbal learning/memory, and verbal fluency. Studies were more likely to find impairment in patients than relatives, suggesting that some neurocognitive deficits may be a result of the illness itself and/or its treatment. However, small sample sizes, differences among relatives studied (e.g., relatedness, diagnostic status, age), and differences in assessment instruments may contribute to inconsistencies in reported neurocognitive performance among relatives. Additional studies addressing these issues are needed. Copyright © 2016 Elsevier Ltd. All rights reserved.
Genetic Testing for Rare Cancer: The Wider Issues.
Jacobs, Chris; Pichert, Gabriella
2016-01-01
Identification of a potential genetic susceptibility to cancer and confirmation of a pathogenic gene mutation raises a number of challenging issues for the patient with cancer, their relatives and the health professionals caring for them. The specific risks and management issues associated with rare cancer types have been addressed in the earlier chapters. This chapter considers the wider issues involved in genetic counselling and genetic testing for a genetic susceptibility to cancer for patients, families and health professionals. The first part of the chapter will present the issues raised by the current practice in genetic counselling and genetic testing for cancer susceptibility. The second part of the chapter will address some of the issues raised by the advances in genetic testing technology and the future opportunities provided by personalised medicine and targeted cancer therapy. Facilitating these developments requires closer integration of genomics into mainstream cancer care, challenging the existing paradigm of genetic medicine, adding additional layers of complexity to the risk assessment and management of cancer and presenting wider issues for patients, families, health professionals and clinical services.
Customer privacy on UK healthcare websites.
Mundy, Darren P
2006-09-01
Privacy has been and continues to be one of the key challenges of an age devoted to the accumulation, processing, and mining of electronic information. In particular, privacy of healthcare-related information is seen as a key issue as health organizations move towards the electronic provision of services. The aim of the research detailed in this paper has been to analyse privacy policies on popular UK healthcare-related websites to determine the extent to which consumer privacy is protected. The author has combined approaches (such as approaches focused on usability, policy content, and policy quality) used in studies by other researchers on e-commerce and US healthcare websites to provide a comprehensive analysis of UK healthcare privacy policies. The author identifies a wide range of issues related to the protection of consumer privacy through his research analysis using quantitative results. The main outcomes from the author's research are that only 61% of healthcare-related websites in their sample group posted privacy policies. In addition, most of the posted privacy policies had poor readability standards and included a variety of privacy vulnerability statements. Overall, the author's findings represent significant current issues in relation to healthcare information protection on the Internet. The hope is that raising awareness of these results will drive forward changes in the industry, similar to those experienced with information quality.
1980-01-01
their livelihood. U.S. consumers in- directly beccme members of this alliance because their interest in taste, nutrition and price leads them to...factor arises when U.S. consumer groups become involved in the issue. Three elements trigger consumer defense of Mexican tomato imports: price, nutrition ...addition, some consumers prefer Mexican tomatoes because they are vine-ripened, a process utilizing more labor but producing more nutritional and more
The treatment of Parkinson's disease with deep brain stimulation: current issues.
Moldovan, Alexia-Sabine; Groiss, Stefan Jun; Elben, Saskia; Südmeyer, Martin; Schnitzler, Alfons; Wojtecki, Lars
2015-07-01
Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients' mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation.
Additive Manufacturing a Liquid Hydrogen Rocket Engine
NASA Technical Reports Server (NTRS)
Jones, Carl P.; Robertson, Elizabeth H.; Koelbl, Mary Beth; Singer, Chris
2016-01-01
Space Propulsion is a 5 day event being held from 2nd May to the 6th May 2016 at the Rome Marriott Park Hotel in Rome, Italy. This event showcases products like Propulsion sub-systems and components, Production and manufacturing issues, Liquid, Solid, Hybrid and Air-breathing Propulsion Systems for Launcher and Upper Stages, Overview of current programmes, AIV issues and tools, Flight testing and experience, Technology building blocks for Future Space Transportation Propulsion Systems : Launchers, Exploration platforms & Space Tourism, Green Propulsion for Space Transportation, New propellants, Rocket propulsion & global environment, Cost related aspects of Space Transportation propulsion, Modelling, Pressure-Thrust oscillations issues, Impact of new requirements and regulations on design etc. in the Automotive, Manufacturing, Fabrication, Repair & Maintenance industries.
Research Committee Issues Brief: Examining Communication and Interaction in Online Teaching
ERIC Educational Resources Information Center
Cavanaugh, Cathy; Barbour, Michael; Brown, Regina; Diamond, Daryl; Lowes, Susan; Powell, Allison; Rose, Ray; Scheick, Amy; Scribner, Donna; Van der Molen, Julia
2009-01-01
Online teaching is a complex professional practice. In addition to their content knowledge and pedagogical skill, online teachers must be qualified in methods of teaching the content online and have experience in online learning. This document examines some of the aspects of online teaching, specifically those related to communication and…
Stress Effects Related to Toxic Waste.
ERIC Educational Resources Information Center
Stefanko, Michael; And Others
The issue of accidental environmental contamination of homes and businesses has been of increasing concern. Actual costs to state and federal governments for relocation of persons and restoration of habitats have run into the tens of millions of dollars. In addition to these real costs, there have been more illusive costs to public health. These…
DOT National Transportation Integrated Search
2010-02-01
States suspend drivers licenses for a variety of offenses that are not directly related to driving safety.1 For example, all states have procedures to suspend licenses for child support arrearages. In addition, a majority of states issue suspensio...
My Life with Adeno-Associated Virus: A Long Time Spent Studying a Short Genome
2013-01-01
My 45 years of studying the molecular biology of adeno-associated virus are recounted. Additional activities as a mentor, department chair, and medical school administrator are described, as are my activities in the public sphere, which involved national issues related to science policy and medical education. PMID:23781880
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-19
... systems capacity to handle the additional traffic associated with the listing and trading of $1 strikes... Relating to Establishing Strike Price Intervals for Options on Trust Issued Receipts, Including Holding... Rules of the Boston Options Exchange Group, LLC (``BOX'') to establish strike price intervals for...
Strive for the Best: Building and Maintaining an Excellent Board
ERIC Educational Resources Information Center
Griswold, John S.; Jarvis, William F.
2014-01-01
The nature of trusteeship has changed markedly in the new century. In addition to the mission-related and financial issues with which fiduciaries have always dealt, trustees of nonprofit organizations are now regularly required to make decisions in response to media scrutiny, challenges from regulators, demands from stakeholders and constituents,…
Biomonitoring over the last 14 years has shown human exposure to environmental chemicals has increased ~10-fold (1). In addition, mortality and morbidity related cardiovascular disease continues to be the leading national and global public health issue (2, 3). The association bet...
Goals and Objectives, 1993 and 1994. Final Report.
ERIC Educational Resources Information Center
Illinois Community Coll. Board, Springfield.
In addition to its routine responsibilities, the Illinois Community College Board (ICCB) has identified special goal areas based on issues of high priority for the Illinois Community College System (ICCS) related to the Board's mission and philosophy. For 1993 and 1994, eight goals were identified: (1) accountability, i.e., to document the…
Enhancing Physical Education with Exergames and Wearable Technology
ERIC Educational Resources Information Center
Lindberg, Renny; Seo, Jungryul; Laine, Teemu H.
2016-01-01
Increases in the numbers of obese and overweight children are a major issue in post-industrial societies because obesity can lead to severe health-related problems. In addition, many challenges affect the quantity and quality of physical education (PE) provided by schools. Exergames that combine exercise with gaming have been recognized as a…
Curriculum Change Management and Workload
ERIC Educational Resources Information Center
Alkahtani, Aishah
2017-01-01
This study examines the ways in which Saudi teachers have responded or are responding to the challenges posed by a new curriculum. It also deals with issues relating to workload demands which affect teachers' performance when they apply a new curriculum in a Saudi Arabian secondary school. In addition, problems such as scheduling and sharing space…
76 FR 78641 - Southwestern Gas Storage Technical Conference; Notice of Public Conference
Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-19
... Storage Technical Conference; Notice of Public Conference Take notice that on February 16, 2012 at 9 a.m... technical conference with interested parties to discuss issues related to natural gas storage development in... Cold Weather Event of February 1-5, 2011: Causes and Recommendations, ``[a]dditional gas storage...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-25
... identified by an interagency working group that is reviewing export control issues related to homeland security. The interagency working group is made up of representatives from the Departments of Commerce, Defense, Homeland Security and State. The purpose of the interagency working group is to ensure that...
Teacher Knowledge, Instructional Expertise, and the Development of Reading Proficiency
ERIC Educational Resources Information Center
Lyon, G. Reid; Weiser, Beverly
2009-01-01
Teacher knowledge and instructional expertise have been found in correlational and pre- and post-test studies to be related to student reading achievement. This article summarizes data presented in this special issue and additional research to address four questions: (a) What do expert reading teachers know? (b) Why do teachers need to acquire…
Curriculum-based Measurement in Assessing Bilingual Students: A Promising New Direction.
ERIC Educational Resources Information Center
Bentz, Johnell; Pavri, Shireen
2000-01-01
This article discusses the problems with traditional methods of assessing bilingual students and describes curriculum-based measurement (CBM) for use with bilingual Hispanic students. Additional information about the features of CBM is presented along with issues related to the use of CBM with bilingual Hispanic students. (Contains references.)…
Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-30
... establish by regulation an additional process for the appeal of decisions of flood insurance claims issued... informal process to handle appeals regarding decisions related to coverage, or claims under the NFIP... to the flood insurance claims process. DATES: Comments must be submitted on or before September 30...
Chocolate and cardiovascular health: is it too good to be true?
Ariefdjohan, Merlin W; Savaiano, Dennis A
2005-12-01
Recent findings indicate that cocoa and chocolate, when processed appropriately, may contain relatively large amounts of flavonoids, particularly catechin and epicatechin. We review the benefits of these flavonoids, specifically with regard to cardiovascular health, and raise several unresolved issues that suggest the need for additional research and product development in this area.
Additional Security Considerations for Grid Management
NASA Technical Reports Server (NTRS)
Eidson, Thomas M.
2003-01-01
The use of Grid computing environments is growing in popularity. A Grid computing environment is primarily a wide area network that encompasses multiple local area networks, where some of the local area networks are managed by different organizations. A Grid computing environment also includes common interfaces for distributed computing software so that the heterogeneous set of machines that make up the Grid can be used more easily. The other key feature of a Grid is that the distributed computing software includes appropriate security technology. The focus of most Grid software is on the security involved with application execution, file transfers, and other remote computing procedures. However, there are other important security issues related to the management of a Grid and the users who use that Grid. This note discusses these additional security issues and makes several suggestions as how they can be managed.
USSR Space Life Sciences Digest, issue 3
NASA Technical Reports Server (NTRS)
Hooke, L. R. (Editor); Radtke, M. (Editor); Garshnek, V. (Editor); Rowe, J. E. (Editor); Teeter, R. (Editor)
1985-01-01
This is the third issue of NASA's USSR Space Life Sciences Digest. Abstracts are included for 46 Soviet periodical articles in 20 areas of aerospace medicine and space biology and published in Russian during the second third of 1985. Selected articles are illustrated with figures and tables from the original. In addition, translated introductions and tables of contents for seven Russian books on six topics related to NASA's life science concerns are presented. Areas covered are adaptation, biospherics, body fluids, botany, cardiovascular and respiratory systems, endocrinology, exobiology, gravitational biology, habitability and environmental effects, health and medical treatment, immunology, life support systems, metabolism, microbiology, musculoskeletal system; neurophysiology, nutrition, perception, personnel selection, psychology, radiobiology, and space physiology. Two book reviews translated from the Russian are included and lists of additional relevant titles available in English with pertinent ordering information are given.
USSR Space Life Sciences Digest, issue 4
NASA Technical Reports Server (NTRS)
Hooke, L. R. (Editor); Radtke, M. (Editor); Garshnek, V. (Editor); Teeter, R. (Editor); Rowe, J. E. (Editor)
1986-01-01
The fourth issue of NASA's USSR Space Life Science Digest includes abstracts for 42 Soviet periodical articles in 20 areas of aerospace medicine and space biology and published in Russian during the last third of 1985. Selected articles are illustrated with figures and tables from the original. In addition, translated introductions and tables of contents for 17 Russian books on 12 topics related to NASA's life science concerns are presented. Areas covered are: adaptation, biological rhythms, biospherics, body fluids, botany, cardiovascular and respiratory systems, cytology, developmental biology, endocrinology, exobiology, habitability and environmental effects, health and medical treatment, hematology, histology, human performance, immunology, mathematical modeling, metabolism, microbiology, musculoskeletal system, neurophysiology, nutrition, perception, personnel selection, psychology, and radiobiology. Two book reviews translated from the Russian are included and lists of additional relevant titles available in English with pertinent ordering information are given.
Stakeholder views on returning research results.
Haga, Susanne B; Zhao, Jennifer Q
2013-01-01
While the disclosure of research findings is relevant to all types of biomedical research, it has garnered particular attention with respect to genetics and genomics research due to some of the unique aspects of the data and the high public profile of the field. In this chapter, we review the attitudes of stakeholders (research participants, policymakers, and researchers) to define areas of consensus regarding the issue of returning research results across and within groups. In addition to stakeholder attitudes about obligations and interest in research results, other major related issues related to returning research results, such as informed consent, communication of research results, and cost, are discussed. Given the consensus between stakeholders to return summary reports of a study's outcomes and individual research results of clinical significance, we conclude that the time has come to encourage, if not require, researchers to consider these issues in the developmental planning stages of a project and to plan and budget accordingly. © 2013 Elsevier Inc. All rights reserved.
Developing a policy for paediatric biobanks: principles for good practice
Hens, Kristien; Van El, Carla E; Borry, Pascal; Cambon-Thomsen, Anne; Cornel, Martina C; Forzano, Francesca; Lucassen, Anneke; Patch, Christine; Tranebjaerg, Lisbeth; Vermeulen, Eric; Salvaterra, Elena; Tibben, Aad; Dierickx, Kris
2013-01-01
The participation of minors in biobank research can offer great benefits for science and health care. However, as minors are a vulnerable population they are also in need of adequate protective measures when they are enrolled in research. Research using biobanked biological samples from children poses additional ethical issues to those raised by research using adult biobanks. For example, small children have only limited capacity, if any, to understand the meaning and implications of the research and to give a documented agreement to it. Older minors are gradually acquiring this capacity. We describe principles for good practice related to the inclusion of minors in biobank research, focusing on issues related to benefits and subsidiarity, consent, proportionality and return of results. Some of these issues are currently heavily debated, and we conclude by providing principles for good practice for policy makers of biobanks, researchers and anyone involved in dealing with stored tissue samples from children. Actual implementation of the principles will vary according to different jurisdictions. PMID:22713814
Does the "new philosophy" in predictive, preventive and personalised medicine require new ethics?
Gefenas, Eugenijus; Cekanauskaite, Asta; Tuzaite, Egle; Dranseika, Vilius; Characiejus, Dainius
2011-06-01
This paper maps the ethical issues that arise in the context of personalised medicine. First, it highlights the ethical problems related to increased predictive power of modern diagnostic interventions. Such problems emerge because the ability to identify individuals or groups of individuals that can potentially benefit from a particular therapeutic intervention also raises a question of personal responsibility for health-related behaviour and lifestyle. The second major area of ethical concern is related to health prevention and distributive justice. The paper discusses the ethical challenges brought by the personalised medicine in the context of the Additional Protocol to the Convention on Human Rights and Biomedicine concerning Genetic Testing for Health Purposes. Finally, it notes that the issue of consent in the context of biobanks, the need to rethink the prevalent models of research designs and to communicate relevant findings to the donors of biological materials deserve further discussion.
Jamison, Robert N; Mao, Jianren
2015-07-01
Chronic pain is an international health issue of immense importance that is influenced by both physical and psychological factors. Opioids are useful in treating chronic pain but have accompanying complications. It is important for clinicians to understand the basics of opioid pharmacology, the benefits and adverse effects of opioids, and related problematic issues of tolerance, dependence, and opioid-induced hyperalgesia. In this article, the role of psychiatric comorbidity and the use of validated assessment tools to identify individuals who are at the greatest risk for opioid misuse are discussed. Additionally, interventional treatment strategies for patients with chronic pain who are at risk for opioid misuse are presented. Specific behavioral interventions designed to improve adherence with prescription opioids among persons treated for chronic pain, such as frequent monitoring, periodic urine screens, opioid therapy agreements, opioid checklists, and motivational counseling, are also reviewed. Use of state-sponsored prescription drug monitoring programs is also encouraged. Areas requiring additional investigation are identified, and the future role of abuse-deterrent opioids and innovative technology in addressing issues of opioid therapy and pain are presented. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
[Problems of Doctor Judym's peers].
Kamiński, J
2000-01-01
This paper is a work on the health conditions of the inhabitants of Rzeszów and the surrounding area in the second half of the 19th century as based on the mortality analysis. A comparison and contrast has been made between the daily work of a doctor nowadays and a hundred years ago. The issues have been presented at various levels, with reference to the political, socio-economic and cultural relations existing at that time. The work is enhanced with additional comments on the doctor's profession and the problem of diagnostic difficulties as well as the possibility of making a mistaken judgement. Additionally, the definition of death at that time and at present has been formulated. The issues of colleague solidarity, ethical and moral issues and the activities of the Doctors' Association over the above mentioned period are also discussed. I noted the "plague" of the time which was the provision of medical treatment by the unqualified. The above considerations may be a starting point for the present, popular discussion on the principles of a doctor's ethics and duty.
The 'Magic Light': A Discussion on Laser Ethics.
Stylianou, Andreas; Talias, Michael A
2015-08-01
Innovations in technology and science form novel fields that, although beneficial, introduce new bio-ethical issues. In their short history, lasers have greatly influenced our everyday lives, especially in medicine. This paper focuses particularly on medical and para-medical laser ethics and their origins, and presents the complex relationships within laser ethics through a three-dimensional matrix model. The term 'laser' and the myth of the 'magic light' can be identified as landmarks for laser related ethical issues. These ethical issues are divided into five major groups: (1) media, marketing, and advertising; (2) economic outcomes; (3) user training; (4) the user-patient/client relationship; and (5) other issues. In addition, issues arising from two of the most common applications of lasers, laser eye surgery and laser tattoo removal, are discussed. The aim of this paper is to demonstrate that the use of medical and para-medical lasers has so greatly influenced our lives that the scientific community must initiate an earnest discussion of medical laser ethics.
Addressing Consent Issues in Donation After Circulatory Determination of Death.
Overby, Kim J; Weinstein, Michael S; Fiester, Autumn
2015-01-01
Given the widening gap between the number of individuals on transplant waiting lists and the availability of donated organs, as well as the recent plateau in donations based on neurological criteria (i.e., brain death), there has been a growing interest in expanding donation after circulatory determination of death. While the prevalence of this form of organ donation continues to increase, many thorny ethical issues remain, often creating moral distress in both clinicians and families. In this article, we address one of these issues, namely, the challenges surrounding patient and surrogate informed consent for donation after circulatory determination of death. First we discuss several general concerns regarding consent related to this form of organ donation, and then we address additional issues that are unique to three different patient categories: adult patients with medical decision-making capacity or potential capacity, adult patients who lack capacity, and pediatric patients.
Genes, race, and psychology in the genome era: an introduction.
Anderson, Norman B; Nickerson, Kim J
2005-01-01
The mapping of the human genome has reawakened interest in the topic of race and genetics, especially the use of genetic technology to examine racial differences in complex outcomes such as health and intelligence. Advances in genomic research challenge psychology to address the myriad conceptual, methodological, and analytical issues associated with research on genetics and race. In addition, the field needs to understand the numerous social, ethical, legal, clinical, and policy implications of research in this arena. Addressing these issues should not only benefit psychology but could also serve to guide such thought in other fields, including molecular biology. The purpose of this special issue is to begin a discussion of this issue of race and genetics within the field of psychology. Several scholars who work in the fields of genetics, race, or related areas were invited to write (or had previously submitted) articles sharing their perspectives. (c) 2005 APA
Issues of organizational cybernetics and viability beyond Beer's viable systems model
NASA Astrophysics Data System (ADS)
Nechansky, Helmut
2013-11-01
The paper starts summarizing the claims of Beer's viable systems model to identify five issues any viable organizations has to deal with in an unequivocal hierarchical structure of five interrelated systems. Then the evidence is introduced for additional issues and related viable structures of organizations, which deviate from Beer's model. These issues are: (1) the establishment and (2) evolution of an organization; (3) systems for independent top-down control (like "Six Sigma"); (4) systems for independent bottom-up correction of performance problems (like "Kaizen"), both working outside a hierarchical structure; (5) pull production systems ("Just in Time") and (6) systems for checks and balances of top-level power (like boards and shareholder meetings). Based on that an evolutionary approach to organizational cybernetics is outlined, addressing the establishment of organizations and possible courses of developments, including recent developments in quality and production engineering, as well as problems of setting and changing goal values determining organizational policies.
Trust in Vaccines: Why It Takes More than Good Faith.
Begg, Norman
2013-08-12
This Vaccines issue on "Confidence in Vaccines" provides sound evidence through multiple perspectives of life-saving impacts when vaccination programs are effectively implemented in a population. Yet there remain challenges to achieving this impact, including scientific, medical, manufacturing, policy-related and logistical issues. Additionally, socio-cultural, religious and political agendas can come into play, taking public health hostage and sometimes allowing the circulation of myths regarding vaccination. All of these challenges play a role in public confidence in vaccines and vaccination. What we trust, we embrace. What we do not trust, we do not embrace.
Avoiding a fate worse than death: an argument for legalising voluntary physician-based euthanasia.
Werren, Julia; Yuksel, Necef; Smith, Saxon
2012-09-01
The legalisation of voluntary physician-based euthanasia is currently the subject of much political, social and ethical debate and there is evidence in Australia of growing support for its implementation. In addressing many of the issues that surround legalisation, the article looks at some overseas jurisdictions that have legalised euthanasia to determine whether the social, political and ethical concerns prominent in the Australian debate have proved problematic in other jurisdictions. In addition, the article examines the report on the Dying with Dignity Bill 2009 (Tas) which commented extensively on the issues relating to voluntary physician-based euthanasia.
Biosimilars and market access: a question of comparability and costs?
Simoens, Steven; Verbeken, Gilbert; Huys, Isabelle
2012-12-01
This article discusses specific issues related to the market access of biosimilars. Biopharmaceuticals are complex molecules produced by living cells. Copies of these medicines, called biosimilars, are not identical to their reference medicine and therefore specific regulatory requirements apply. When considering the use of biosimilars, the question of the degree of comparability between a biosimilar and the reference biopharmaceutical needs to be considered for registration, pricing and reimbursement purposes in addition to the cost issue. To date, many key concepts (like clinically meaningful differences) remain undefined and the question of the degree of comparability is not yet resolved.
Schuhwerk, M A; Richens, J; Zuckerman, Jane N
2006-01-01
There is a high demand for travel among HIV-positive individual. This demand arises partly from those who have benefited from advances in antiretroviral therapy as well as those with disease progression. The key to a successful and uneventful holiday lies in careful pre-trip planning, yet many patients fail to obtain advice before travelling. Travel advice for HIV patients is becoming increasingly specialized. In addition to advice on common travel-related infectious diseases, HIV-positive travellers are strongly advised to carry information with them and they need specific advice regarding country entry restrictions, HIV inclusive travel insurance, safety of travel vaccinations and highly active antiretroviral therapy-related issues. A wide range of relevant issues for the HIV-positive traveller are discussed in this review and useful websites can be found at the end.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wood, Richard Thomas; Ewing, Paul D.
The U.S. Nuclear Regulatory Commission’s (NRC’s) regulations in Part 50, “Domestic Licensing of Production and Utilization Facilities,” of Title 10 of the Code of Federal Regulations (10 CFR Part 50) state that structures, systems, and components important to safety in a nuclear power plant are to be designed to accommodate the effects of environmental conditions (i.e., remain functional under all postulated service conditions) and that design control measures such as testing are to be used to check the adequacy of design. Regulatory Guide (RG) 1.180 was developed to provide guidance to licensees and applicants on methods acceptable to the NRCmore » staff for complying with the NRC’s regulations on design, installation, and testing practices for addressing the effects of electromagnetic and radio-frequency interference (EMI/RFI) and power surges on safety-related instrumentation and control (I&C) systems. The first revision of RG 1.180 was issued in January 2000 and a second revision was issued in October 2003*. The second revision differed from the first revision in endorsing Military Standard (MIL-STD)-461E and the International Electrotechnical Commission (IEC) Standard (Std) 61000 series of EMI/RFI test methods, extending the guidance to cover signal line testing, incorporating frequency ranges where portable communications devices are experiencing increasing use, and relaxing the operating envelopes (test levels) when experience and confirmatory research warranted. It also offered exemptions from specific test criteria based on technical considerations such as plant conditions and the intended location of the safety-related I&C equipment. Since the last revision, new requirements have been identified, associated RGs have been created and updated, and additional industry guidance has been developed. Additionally, the operational environment has changed with the increase in wireless communication technology for both personal (smartphone) and industrial (remote I&C) purposes. Also, specific concerns and issues with testing methods and methodologies have been identified that must be addressed. Further, most of the standards that serve as the basis for the RG have been revised. Therefore, the NRC’s Office of Regulatory Research has contracted with Oak Ridge National Laboratory (ORNL) to incorporate new information and resolve the identified issues under NRC-HQ-60-14-D-0015, “Update to RG 1.180, Revision 2, Guidelines for Evaluating Electromagnetic and Radio-Frequency Interference in Safety-Related Instrumentation and Control Systems.” The ultimate goal of this project is to provide NRC the technical basis for developing and publishing a new revision of the RG. The focus of Task 4 was for ORNL to identify and address any new or additional EMI/RFI issues that could potentially impact the EMC of I&C systems. More specifically, ORNL was to evaluate the impact of any new issue on safety equipment in their local environments and then determine whether the issues should be included and discussed in the revision to RG 1.180 that is currently under way.« less
The study of direct-to-consumer advertising for prescription drugs.
Schommer, Jon C; Hansen, Richard A
2005-06-01
The objectives of this article are to (1) identify key methodological issues related to investigating the effects of direct-to-consumer advertising (DTCA) for prescription drugs, (2) highlight opportunities and challenges that these issues pose, and (3) provide suggestions to address these challenges and opportunities from a social and administrative pharmacy perspective. Through a review of existing literature and consultation with research colleagues, we identified 3 broad issues regarding the study of DTCA for prescription drugs: (1) the importance of problem formulation, (2) the role of health behavior and decision-making perspectives, and (3) data collection and data analysis challenges and opportunities. Based upon our findings, we developed recommendations for future research in this area. Clear problem formulation will be instructive for prioritizing research needs and for determining the role that health behavior and decision-making perspectives can serve in DTCA research. In addition, it appears that cluster bias, nonlinear relationships, mediating/moderating effects, time effects, acquiescent response, and case mix are particularly salient challenges for the DTCA research domain. We suggest that problem formulation, selection of sound theories upon which to base research, and data collection and data analysis challenges are key methodological issues related to investigating the effects of DTCA for prescription drugs.
2009-09-30
related issues-- lack of in-country materiel, problems encountered with procurement of land, lack of skilled contractors and labor , and security...have not been well-maintained because of the lack of skilled labor in the Army and Police, and among the general Afghan population. In addition, the...National Labor Relations Board—Funding of Subscription Contracts, B- 309530 (September 17, 2007). This decision provides possible exceptions to the
Teaching Environmental Geology in the 21St Century: A Workshop Report
NASA Astrophysics Data System (ADS)
Mogk, D. W.; Wiese, K.; Castendyk, D.; McDaris, J. R.
2012-12-01
Environmental Geology encompasses a range of topics that include geohazards, natural resources, issues such as climate change, human health, and environmental policy. Instruction in Environmental Geology provides students the opportunity to address the grand challenges facing humanity regarding how to live sustainably and responsibly on Earth. Instruction in Environmental Geology ranges from dedicated introductory courses, instructional modules in upper division Earth Science "core" classes, to courses in related disciplines such as environmental science, ecology, and the social and political sciences. To explore the opportunities of teaching Environmental Geology in all these contexts, the On the Cutting Edge program convened a workshop in June 2012 to bring together instructors representing a diversity of instructional settings. The goals of the workshop were to: 1) Share innovative teaching methods, approaches, and activities for teaching Environmental Geology and share ideas on how to teach in various contexts. 2) Examine where and how environmental geology topics are taught in the geoscience curriculum from introductory courses for non-majors to "core" geoscience courses for majors. 3) Consider the ways that Environmental Geology courses and topical materials can contribute to public science literacy, particularly how to make personal and societal decisions about the range of issues facing humanity and to live responsibly and sustainably on this planet. 4) Develop a list of best practices for integrating emerging environmental issues, recent natural disasters, and issues related to natural resources into course work and identifying how scientific data and research outcomes can inform public discourse on topical issues. 5) Develop strategies to reach under-represented groups and expand the diversity of students who enroll in our courses. 6) Identify topics of high interest and need for future development as teaching modules and courses. The workshop program included keynote talks, small group discussion sessions, interactive demonstrations, and opportunities to network and develop ideas for new instructional resources. The participants also reviewed over 300 teaching activities, and contributed to additional online resources focused on Environmental Geology. Field trips demonstrated teaching activities about environmental issues in local contexts. All workshop presentations, discussion summaries, teaching activity collections and related on-line resources are available on the workshop website. Faculty are encouraged to submit additional examples of Environmental Geology instructional resources.
NASA Astrophysics Data System (ADS)
Gresch, Helge; Hasselhorn, Marcus; Bögeholz, Susanne
2013-10-01
Dealing with socio-scientific issues in science classes enables students to participate productively in controversial discussions concerning ethical topics, such as sustainable development. In this respect, well-structured decision-making processes are essential for elaborate reasoning. To foster decision-making competence, a computer-based programme was developed that trains secondary school students (grades 11-13) in decision-making strategies. The main research question is: does training students to use these strategies foster decision-making competence? In addition, the influence of meta-decision aids was examined. Students conducted a task analysis to select an appropriate strategy prior to the decision-making process. Hence, the second research question is: does combining decision-making training with a task analysis enhance decision-making competence at a higher rate? To answer these questions, 386 students were tested in a pre-post-follow-up control-group design that included two training groups (decision-making strategies/decision-making strategies combined with a task analysis) and a control group (decision-making with additional ecological information instead of strategic training). An open-ended questionnaire was used to assess decision-making competence in situations related to sustainable development. The decision-making training led to a significant improvement in the post-test and the follow-up, which was administered three months after the training. Long-term effects on the quality of the students' decisions were evident for both training groups. Gains in competence when reflecting upon the decision-making processes of others were found, to a lesser extent, in the training group that received the additional meta-decision training. In conclusion, training in decision-making strategies is a promising approach to deal with socio-scientific issues related to sustainable development.
Student Identity Considerations and Implications Associated with Socioscientific Issues Instruction
NASA Astrophysics Data System (ADS)
Ruzek, Mitchel James
The purpose of this investigation was to explore how aspects of identity, perceived levels of controversy, and the strength of a student's attachment to their controversial identity relate to conceptual understanding and knowledge acquisition during socioscientific issues (SSI) based instruction in a biology classroom. The knowledge gained from this study will have the capacity to enhance our understanding of the role that attachment to identity plays during SSI negotiation. Additionally, insight was gained into the role played by aspects of identity in conceptual understanding of scientifically controversial topics during SSI based instruction. This study contributed to the existing knowledge base in science education by illuminating processes involved in socioscientific issue navigation among students of differing perceptions of controversy as well as students who held aspects of controversial identity that may or may not interact with the specific issues chosen. Students demonstrated evidence of variations of reasoning, justification, perception of controversy, and aspects of knowledge gain as they negotiated the issues of marijuana safety and fast food legality. Additionally, evidence was provided that showed general knowledge gain throughout the group during socioscientific issues instruction. It has been said that one of the appeals of the SSI instructional model is that is serves not only as a context for the delivery of content, but acts as a catalyst for various forms of epistemological beliefs and research into the development of conceptual and psychological knowledge structures (Zeidler, 2013). This investigation supports the deeper understanding of the contribution of controversy perception to epistemology as well as conceptual and psychological knowledge structures during SSI navigation.
40 CFR 1051.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2011 CFR
2011-07-01
.... In addition, within 45 days after the end of the model year, you must send us a report describing... of all applications and any summary information you send us. (2) Any of the information we specify in... temperatures and relative humidity readings) for one year after we issue the associated certificate of...
40 CFR 1051.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2012 CFR
2012-07-01
.... In addition, within 45 days after the end of the model year, you must send us a report describing... of all applications and any summary information you send us. (2) Any of the information we specify in... temperatures and relative humidity readings) for one year after we issue the associated certificate of...
40 CFR 1051.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2014 CFR
2014-07-01
.... In addition, within 45 days after the end of the model year, you must send us a report describing... of all applications and any summary information you send us. (2) Any of the information we specify in... temperatures and relative humidity readings) for one year after we issue the associated certificate of...
40 CFR 1051.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2013 CFR
2013-07-01
.... In addition, within 45 days after the end of the model year, you must send us a report describing... of all applications and any summary information you send us. (2) Any of the information we specify in... temperatures and relative humidity readings) for one year after we issue the associated certificate of...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-26
... controls on trading; information and data relating to the index, including the design, computation and... futures contract raises novel or complex issues that require additional time for review, or if the foreign... composition, computation, or method of selection of component entities of an index referenced and defined in...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-10
... retirement income decisions. 3. Disclosure of Account Balances as Monthly Income Streams. Many commenters... that, in addition to their account balance, sets forth their benefit in the form of a monthly lifetime benefit. If so, should such income streams be based on the participant's accrued benefit (account balance...
Using Generalizability Theory to Examine Different Concept Map Scoring Methods
ERIC Educational Resources Information Center
Cetin, Bayram; Guler, Nese; Sarica, Rabia
2016-01-01
Problem Statement: In addition to being teaching tools, concept maps can be used as effective assessment tools. The use of concept maps for assessment has raised the issue of scoring them. Concept maps generated and used in different ways can be scored via various methods. Holistic and relational scoring methods are two of them. Purpose of the…
Watershed Central was developed to be a bridge between sharing and searching for information relating to watershed issues. This is dependent upon active user support through additions and updates to the Watershed Central Wiki. Since the wiki is user driven, the content and applic...
Exploring Reviewer Reactions to Manuscripts Submitted to Academic Journals
ERIC Educational Resources Information Center
Coniam, David
2012-01-01
This paper extends a previous study (Coniam, 2011) into a corpus of manuscript (MS) reviews conducted for the journal System by one reviewer in the eight-year period 2003-2011. The current paper highlights additional facets of the review process that focus on issues involving authors themselves. The study examines two related sets of research…
Affirmative Action: The Answer to Discrimination? An AEI Round Table Held on May 28, 1975.
ERIC Educational Resources Information Center
Winter, Ralph K.; And Others
The participants in this discussion in addition to Ralph Winter, the moderator, include Owen Fiss and Richard Posner, professors of law; Vera Glaser and William Raspberry, newspaper columnists; and Paul Seabury, professor of political science. These specialists address various legal, ethical and practical issues related to the elimination of…
ERIC Educational Resources Information Center
Can, Ahmet
2015-01-01
The purpose of the study was to explore the influence of adjustment problems, homesickness, and perceived discrimination on the psychological well-being of international college students. Additionally, there was an examination of whether there were any gender differences as they relate to adjustment issues, homesickness, perceived discrimination…
ERIC Educational Resources Information Center
Association of Colleges of Applied Arts and Technology of Ontario, North York.
This paper estimates the expenditures, revenue, and related implications for Ontario's Colleges of Applied Arts and Technology (Canada), using a specific set of hypotheses and assumptions. The Ministry of Training, Colleges, and Universities estimates a demand for an additional 37,400 spaces (a 27% increase in full-time enrollment) by 2010. In…
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-21
... international terrorism.'' \\1\\ In addition, the Secretary is authorized to impose anti-money laundering (``AML... the MSB from being used to facilitate money laundering and the financing of terrorist activities; \\7... businesses posed a high risk of money laundering and terrorist financing. In 2006, FinCEN issued an advance...
Continuing professional education: Status, trends, and issues related to electronic delivery
NASA Technical Reports Server (NTRS)
Rothenberg, D.
1975-01-01
Four professional groups, teachers, doctors, lawyers, and engineers were examined to determine if they constitute a potential market for continuing professional education via large scale electronic technology. Data were collected in view of social and economic forces, such as mandatory periodic relicensure, additional course requirements for certification, or the economic health of supporting industries.
20 CFR 667.200 - What general fiscal and administrative rules apply to the use of WIA title I funds?
Code of Federal Regulations, 2010 CFR
2010-04-01
... 29 CFR 97.36(b)(3) (as appropriate), which address codes of conduct and conflict of interest issues... training and related services, by itself, violates these conflict of interest provisions. (5) The addition... workplace requirements. All WIA title I grant recipients and subrecipients must comply with the government...
ERIC Educational Resources Information Center
Walick, Christopher M.; Sullivan, Amanda L.
2015-01-01
Somali immigrants and refugees have entered the United States with increasing frequency due to civil war-induced violence and instability in their native country. The resultant increase of Somali students is of particular relevance to educators and school psychologists because Somali youth possess unique cultural backgrounds. In addition, refugee…
Mentoring in Black and White: The Intricacies of Cross-Cultural Mentoring
ERIC Educational Resources Information Center
Johnson-Bailey, Juanita; Cervero, Ronald M.
2004-01-01
Cross-cultural mentoring relationships can be sites of struggle around the issues of race, class and gender. In addition, the mentor/protege relationship offers micro-cosmic insight into power relations within western society. The authors of this paper, a black woman associate professor and a white male professor, use the example of their…
A Planning Model for Post-Secondary Education in West Central Minnesota.
ERIC Educational Resources Information Center
Kuch, Peter Jacob
This study presents a methodology for planning the efficient development of the educational infrastructure in a region. It is primarily concerned with solving the problem of how one allocates an exogenously fixed set of resources among different educational programs. In addition it deals with such related issues as: How does one choose among…
The term "environmental justice" is a relatively recent addition to the lexicon of public health and risk-based decision making. Although it is currently a prominent public policy issue, there is no consensus-derived definition, nor is there general agreement about via...
For Lesbian Parents: Your Guide to Helping Your Family Grow Up Happy, Healthy, and Proud.
ERIC Educational Resources Information Center
Johnson, Suzanne M.; O'Connor, Elizabeth
In addition to those adjustments that any new parents must make, lesbian mothers face numerous special concerns. This book offers information and support for lesbian parents on relations between lesbian mothers and the outside world, child development and social issues, and special circumstances. Chapter 1 introduces a group of lesbian mothers and…
The treatment of Parkinson's disease with deep brain stimulation: current issues
Moldovan, Alexia-Sabine; Groiss, Stefan Jun; Elben, Saskia; Südmeyer, Martin; Schnitzler, Alfons; Wojtecki, Lars
2015-01-01
Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients’ mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation. PMID:26330809
Beyond the 'safe sex' propaganda.
Hadzic, Maja; Khajehei, Marjan
2010-01-01
In this paper, we discuss sexual relationships among teenagers, the related issues, and suggest addressing the issues through effective education programs for both teenagers and their parents. We also discuss the main issues resulting from initiation of sexual relationship during adolescence such as unwanted pregnancy, maternal mortality, abortion, sexually transmitted diseases and damaged mental health. In addition, we highlight the lack of adequate sex education in teenagers and emphasize on the negative influence of TV programs and the harmful effects of dysfunctional families. Moreover, this article proposes equipping teenagers with knowledge that will help them understand not only physical but also emotional, social, and mental dynamics of sexual relationships. We believe that this approach would intervene much earlier in their life, help teenagers make healthy decision and minimize negative consequences of their personal choices.
Perkins, Emily R; Yancey, James R; Drislane, Laura E; Venables, Noah C; Balsis, Steve; Patrick, Christopher J
2017-01-01
Recent research initiatives have called for an increased use of biological concepts and measures in defining and studying mental health problems, but important measurement-related challenges confront efforts in this direction. This article highlights some of these challenges with reference to an intriguing measure of neural reactivity: the probe P3 response, a mid-latency brain potential evoked by an intense, unexpected acoustic-probe stimulus. Using data for a large adult sample (N=418), we report evidence that amplitude of probe P3 response to unwarned noise bursts occurring in a picture-viewing task exhibits robust, independent associations with two distinct trait constructs: weak inhibitory control (or disinhibition; DIS) and threat sensitivity (THT). Additionally, we report a selective association for THT with attentional suppression of probe P3 response during viewing of aversive pictures compared to neutral. These results point to separable elements of variance underlying the probe P3 response, including one element reflecting DIS-related variations in cognitive-elaborative processing, and others reflecting THT-related variations in aversive foreground engagement and abrupt defensive reorientation. Key measurement issues are considered in relation to these specific findings, and methodological and statistical approaches for addressing these issues are discussed in relation to advancement of a quantitatively sound, biologically informed science of psychopathology. Copyright © 2016 Elsevier B.V. All rights reserved.
Perkins, Emily R.; Yancey, James R.; Drislane, Laura E.; Venables, Noah C.; Balsis, Steve; Patrick, Christopher J.
2016-01-01
Recent research initiatives have called for an increased use of biological concepts and measures in defining and studying mental health problems, but important measurement-related challenges confront efforts in this direction. This article highlights some of these challenges with reference to an intriguing measure of neural reactivity: the probe P3 response, a mid-latency brain potential evoked by an intense, unexpected acoustic-probe stimulus. Using data for a large adult sample (N = 418), we report evidence that amplitude of probe P3 response to unwarned noise bursts occurring in a picture-viewing task exhibits robust, independent associations with two distinct trait constructs: weak inhibitory control (or disinhibition; DIS) and threat sensitivity (THT). Additionally, we report a selective association for THT with attentional suppression of probe P3 response during viewing of aversive pictures compared to neutral. These results point to separable elements of variance underlying the probe P3 response, including one element reflecting DIS-related variations in cognitive-elaborative processing, and others reflecting THT-related variations in aversive foreground engagement and abrupt defensive reorientation. Key measurement issues are considered in relation to these specific findings, and methodological and statistical approaches for addressing these issues are discussed in relation to advancement of a quantitatively sound, biologically informed science of psychopathology. PMID:27856400
Safety and Regulatory Issues of the Thorium Fuel Cycle
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ade, Brian; Worrall, Andrew; Powers, Jeffrey
2014-02-01
Thorium has been widely considered an alternative to uranium fuel because of its relatively large natural abundance and its ability to breed fissile fuel (233U) from natural thorium (232Th). Possible scenarios for using thorium in the nuclear fuel cycle include use in different nuclear reactor types (light water, high temperature gas cooled, fast spectrum sodium, molten salt, etc.), advanced accelerator-driven systems, or even fission-fusion hybrid systems. The most likely near-term application of thorium in the United States is in currently operating light water reactors (LWRs). This use is primarily based on concepts that mix thorium with uranium (UO2 + ThO2),more » add fertile thorium (ThO2) fuel pins to LWR fuel assemblies, or use mixed plutonium and thorium (PuO2 + ThO2) fuel assemblies. The addition of thorium to currently operating LWRs would result in a number of different phenomenological impacts on the nuclear fuel. Thorium and its irradiation products have nuclear characteristics that are different from those of uranium. In addition, ThO2, alone or mixed with UO2 fuel, leads to different chemical and physical properties of the fuel. These aspects are key to reactor safety-related issues. The primary objectives of this report are to summarize historical, current, and proposed uses of thorium in nuclear reactors; provide some important properties of thorium fuel; perform qualitative and quantitative evaluations of both in-reactor and out-of-reactor safety issues and requirements specific to a thorium-based fuel cycle for current LWR reactor designs; and identify key knowledge gaps and technical issues that need to be addressed for the licensing of thorium LWR fuel in the United States.« less
Space benefits: The secondary application of aerospace technology in other sectors of the economy
NASA Technical Reports Server (NTRS)
1976-01-01
A 'Benefit Briefing Notebook' was prepared for the NASA Technology Utilization Office to provide accurate, convenient, and integrated resource information on the transfer of aerospace technology to other sectors of the U.S. economy. The contents are divided into three sections: (1) transfer overview, (2) benefit cases, and (3) indexes. The transfer overview section provides a general perspective for technology transfer from NASA to other organizations. In addition to a description of the basic transfer modes, the selection criteria for notebook examples and the kinds of benefit data they contain are also presented. The benefits section is subdivided into nineteen subject areas. Each subsection presents one or more key issues of current interest, with discrete transfer cases related to each key issue. Additional transfer examples relevant to each subject area are then presented. Pertinent transfer data are given at the end of each example.
NASA Astrophysics Data System (ADS)
Meng, Fanyong
2018-02-01
Triangular fuzzy reciprocal preference relations (TFRPRs) are powerful tools to denoting decision-makers' fuzzy judgments, which permit the decision-makers to apply triangular fuzzy ratio rather than real numbers to express their judgements. Consistency analysis is one of the most crucial issues in preference relations that can guarantee the reasonable ranking order. However, all previous consistency concepts cannot well address this type of preference relations. Based on the operational laws on triangular fuzzy numbers, this paper introduces an additive consistency concept for TFRPRs by using quasi TFRPRs, which can be seen as a natural extension of the crisp case. Using this consistency concept, models to judging the additive consistency of TFRPRs and to estimating missing values in complete TFRPRs are constructed. Then, an algorithm to decision-making with TFRPRs is developed. Finally, two numerical examples are offered to illustrate the application of the proposed procedure, and comparison analysis is performed.
Zamanipoor Najafabadi, Amir H; Peeters, Marthe C M; Lobatto, Daniel J; Broekman, Marieke L D; Smith, Timothy R; Biermasz, Nienke R; Peerdeman, Saskia M; Peul, Wilco C; Taphoorn, Martin J B; van Furth, Wouter R; Dirven, Linda
2017-11-01
The clinical relevance of Health-Related Quality of Life (HRQoL) in meningioma patients has been increasingly acknowledged in recent years. Various questionnaires have been used. However, almost none of these questionnaires has been particularly developed for and/or validated in this patient group. Therefore, the aim of this study was to assess the relevance and comprehensiveness of existing HRQoL questionnaires used in meningioma research and to assess the agreement between patients and health care professionals (HCPs) on the most relevant and important HRQoL issues. A systematic literature search, following the PRISMA statement, was conducted to identify all HRQoL questionnaires used in meningioma research. Semi-structured interviews were organized with patients and HCPs to (1) assess the relevance of all issues covered by the questionnaires (score 0-3: not relevant-highly relevant), (2) assess the ten most important issues, and (3) identify new relevant HRQoL issues. Fourteen different questionnaires were found in the literature, comprising 140 unique issues. Interviews were conducted with 20 patients (median age 57, 71% female) and 10 HCPs (4 neurosurgeons, 2 neurologists, 2 radiotherapists, 1 rehabilitation specialist, 1 neuropsychologist; median experience 13 years). Meningioma patients rated 17-80% of the issues in each of the questionnaires as relevant, HCPs 90-100%. Patients and HCPs agreed on the relevance of only 49 issues (35%, Cohen's kappa: 0.027). Both patients and HCPs considered lack of energy the most important issue. Patients and HCPs suggested five additional relevant issues not covered by current HRQoL questionnaires. Existing HRQoL questionnaires currently used in meningioma patients do not fully cover all relevant issues to these patients. Agreement between patients and HCPs on the relevance of issues was poor. Both findings support the need to develop and validate a meningioma-specific HRQoL questionnaire.
Contributions to the Content Analysis of Gender Roles: An Introduction to a Special Issue
Popova, Lucy; Linz, Daniel G.
2011-01-01
This special issue on gender-related content analysis is the second of two parts (see Rudy et al. 2010b). The current special issue is more diverse than was the first in the number of countries that are represented and in the variety of media genres and content types that are included. The primary aim of this paper is to outline some of the contributions of the individual papers in this second special issue. Some of these advancements and innovations include (a) examining underresearched measures, countries, time spans, sexual orientations, and individual media programs; (b) addressing both international and intranational differences in gender-role portrayals; (c) comparing multiple content formats within the same media unit; (d) updating past findings to take into consideration the current media landscape; (e) employing established measures in novel ways and novel contexts; (f) uncovering limitations in established intercultural measures and media-effects theories; (g) suggesting variables that could predict additional differences in gender-role portrayals; (h) adopting virtually identical methods and measures across distinct content categories in order to facilitate comparisons; (i) conducting multiple tests of a given hypothesis; (j) examining, from multiple perspectives, the implications of racial differences in gender portrayals; and (k) examining the implications of underrepresentation of women and the perspectives that women hold. In addition to the original content-analytical research presented in this special issue, two reviews, one methodological and the other analytical, offer recommendations of procedures and perspectives to be implemented in future research. PMID:21423330
Contributions to the Content Analysis of Gender Roles: An Introduction to a Special Issue.
Rudy, Rena M; Popova, Lucy; Linz, Daniel G
2011-02-01
This special issue on gender-related content analysis is the second of two parts (see Rudy et al. 2010b). The current special issue is more diverse than was the first in the number of countries that are represented and in the variety of media genres and content types that are included. The primary aim of this paper is to outline some of the contributions of the individual papers in this second special issue. Some of these advancements and innovations include (a) examining underresearched measures, countries, time spans, sexual orientations, and individual media programs; (b) addressing both international and intranational differences in gender-role portrayals; (c) comparing multiple content formats within the same media unit; (d) updating past findings to take into consideration the current media landscape; (e) employing established measures in novel ways and novel contexts; (f) uncovering limitations in established intercultural measures and media-effects theories; (g) suggesting variables that could predict additional differences in gender-role portrayals; (h) adopting virtually identical methods and measures across distinct content categories in order to facilitate comparisons; (i) conducting multiple tests of a given hypothesis; (j) examining, from multiple perspectives, the implications of racial differences in gender portrayals; and (k) examining the implications of underrepresentation of women and the perspectives that women hold. In addition to the original content-analytical research presented in this special issue, two reviews, one methodological and the other analytical, offer recommendations of procedures and perspectives to be implemented in future research.
Gill, Amreeta; Shellock, Frank G
2012-01-09
Metallic skin closure staples and vessel ligation clips should be tested at 3-Tesla to characterize MRI issues in order to ensure patient safety. Therefore, metallic surgical implants were assessed at 3-Tesla for magnetic field interactions, MRI-related heating, and artifacts. A skin closure staple (Visistat Skin Stapler, staple, Polytetrafluoroethylene, PTFE, coated 316L/316LVM stainless steel; Teleflex Medical, Durham, NC) and a vessel ligation clip (Hemoclip Traditional, stainless steel; Teleflex Medical, Durham, NC) that represented the largest metallic sizes made from materials with the highest magnetic susceptibilities (i.e., based on material information) among 61 other surgical implants (52 metallic implants, 9 nonmetallic implants) underwent evaluation for magnetic field interactions, MRI-related heating, and artifacts using standardized techniques. MRI-related heating was assessed by placing each implant in a gelled-saline-filled phantom with MRI performed using a transmit/receive RF body coil at an MR system reported, whole body averaged SAR of 2.9-W/kg for 15-min. Artifacts were characterized using T1-weighted, SE and GRE pulse sequences. Each surgical implant showed minor magnetic field interactions (20- and 27-degrees, which is acceptable from a safety consideration). Heating was not substantial (highest temperature change, ≤ 1.6°C). Artifacts may create issues if the area of interest is in the same area or close to the respective surgical implant. The results demonstrated that it would be acceptable for patients with these metallic surgical implants to undergo MRI at 3-Tesla or less. Because of the materials and dimensions of the surgical implants that underwent testing, these findings pertain to 61 additional similar implants.
2012-01-01
Purpose Metallic skin closure staples and vessel ligation clips should be tested at 3-Tesla to characterize MRI issues in order to ensure patient safety. Therefore, metallic surgical implants were assessed at 3-Tesla for magnetic field interactions, MRI-related heating, and artifacts. Methods A skin closure staple (Visistat Skin Stapler, staple, Polytetrafluoroethylene, PTFE, coated 316L/316LVM stainless steel; Teleflex Medical, Durham, NC) and a vessel ligation clip (Hemoclip Traditional, stainless steel; Teleflex Medical, Durham, NC) that represented the largest metallic sizes made from materials with the highest magnetic susceptibilities (i.e., based on material information) among 61 other surgical implants (52 metallic implants, 9 nonmetallic implants) underwent evaluation for magnetic field interactions, MRI-related heating, and artifacts using standardized techniques. MRI-related heating was assessed by placing each implant in a gelled-saline-filled phantom with MRI performed using a transmit/receive RF body coil at an MR system reported, whole body averaged SAR of 2.9-W/kg for 15-min. Artifacts were characterized using T1-weighted, SE and GRE pulse sequences. Results Each surgical implant showed minor magnetic field interactions (20- and 27-degrees, which is acceptable from a safety consideration). Heating was not substantial (highest temperature change, ≤ 1.6°C). Artifacts may create issues if the area of interest is in the same area or close to the respective surgical implant. Conclusions The results demonstrated that it would be acceptable for patients with these metallic surgical implants to undergo MRI at 3-Tesla or less. Because of the materials and dimensions of the surgical implants that underwent testing, these findings pertain to 61 additional similar implants. PMID:22230200
The all electric airplane-benefits and challenges
NASA Technical Reports Server (NTRS)
Spitzer, C. R.; Hood, R. V.
1982-01-01
The all electric aircraft considered in the present investigation is an aircraft which has digital flight crucial controls, electromechanical actuators, and electrical secondary power. There are no hydraulic or pneumatic systems. The characteristics of an all electric aircraft are related to reduced acquisition cost, reduced weight, reduced fuel consumption, increased reliability, reduced support equipment, simpler maintenance, an expanded flight envelope, and improved survivability. An additional benefit is the dramatically increased design flexibility and mission adaptability. However, the implementation of the all electric aircraft concept requires the resolution of a number of major technology issues. Issues in the digital flight controls area are related to achieving the required levels of safety and reliability in a cost effective manner. Other challenges which have to be met are concerned with electromechanical actuators, environmental control and ice protection systems, and engine technology.
Blood bank on-call physician's experiences at a large university medical center.
Bryant, Barbara J; Alperin, Jack B; Indrikovs, Alexander J
2005-01-01
The responsibilities of the blood bank on-call physician (blood bank physician from here on) encompass many aspects of transfusion medicine and physician education. This physician is available 24 hours a day to address any issues concerning the collection and transfusion of blood and blood components. The purpose of this study was to identify and categorize the issues that may confront a blood bank physician. Each call received over a 4-month period was logged and the resolution documented. The calls were grouped into five categories: donor issues, therapeutic procedure issues, patient issues, physician education issues, and requests for blood components not meeting previously defined transfusion guidelines. The blood bank physician received 224 calls during the study period. To resolve each issue, an additional 1 to 14 telephone calls were needed to gather further information. Number of calls by category were donor issues, 20 (8.9%); therapeutic procedure issues, 9 (4.0%); patient issues, 4 (1.8%); physician education issues, 33 (14.7%); and requests for blood components not meeting previously defined transfusion guidelines, 158 (70.6%). Requests for blood components were denied in 39.8 percent of the cases not meeting guidelines. Other forms of therapy were warranted in 20.9 percent of the cases. This study revealed that 85.3 percent of the calls referred to the blood bank physician related to physician education and the appropriateness of blood component orders. These results emphasize the need for ongoing education of medical staff in transfusion medicine issues.
Home intravenous therapy: Part I--Issues.
McAbee, R R; Grupp, K; Horn, B
1991-01-01
Concerns related to providing home intravenous therapy were among the top ten clinical problems identified by Northwest Medicare-certified home care agencies in a 1986 survey. This paper addresses issues related to home intravenous therapy and provides lists of resources for the development of home intravenous therapy programs. Part I of the paper covers concerns related to intravenous therapy as expressed by home care agencies in the Northwest and synthesized the literature about home intravenous therapies. Survey results are presented, followed by a discussion of client and caregiver concerns. These include: discharge planning, client admission criteria and client and caregiver education. Standards, staffing, and staff education issues are discussed followed by sections on economics, marketing regulations and legal and ethical concerns. Finally, there is a discussion of issues related to specific types of intravenous therapies: parenteral nutrition, antibiotic therapy; chemotherapy; blood and blood component therapy and other less frequently used types of intravenous therapies. Each therapy is discussed with regard to complications, client and caregiver instruction and financial considerations. Part II of the paper is a resource guide which lists resources that agencies may use to develop a home intravenous therapy program. In the first section, national organizations and journals and books concerned with intravenous therapy are listed as well as journal articles, guidelines and guidebooks and client and provider educational materials. National and regional product and service representatives of intravenous therapy related companies are also listed. In the second section, addresses for the State Boards of Nursing are given for Alaska, Idaho, Montana, Oregon and Washington. Each state section includes a list of those agencies who indicated in the 1988 survey that they would be willing to share materials. In addition, product and service vendors of intravenous therapy supplies and equipment are listed for the State of Washington.
Electronic device aspects of neural network memories
NASA Technical Reports Server (NTRS)
Lambe, J.; Moopenn, A.; Thakoor, A. P.
1985-01-01
The basic issues related to the electronic implementation of the neural network model (NNM) for content addressable memories are examined. A brief introduction to the principles of the NNM is followed by an analysis of the information storage of the neural network in the form of a binary connection matrix and the recall capability of such matrix memories based on a hardware simulation study. In addition, materials and device architecture issues involved in the future realization of such networks in VLSI-compatible ultrahigh-density memories are considered. A possible space application of such devices would be in the area of large-scale information storage without mechanical devices.
O'Keeffe, Gwenn Schurgin
2012-06-01
Pediatricians care for children's growth and development from the time they are born until they become adults. In addition, pediatricians must be vigilant for external influences. Technology influences children of all ages. Seventy-five percent of teenagers own cell phones, with 25% using them for social media. Technology can lead to an increase in skills and social benefits but there is also the potential for harm such as sexting, cyberbullying, privacy issues, and Internet addiction, all of which can affect health. Pediatricians must become well versed in the new media to provide media-oriented anticipatory guidance and advice on media-related issues. Copyright © 2012 Elsevier Inc. All rights reserved.
Ethics and animal issues in US medical education.
Wiebers, D O; Barron, R A; Leaning, J; Ascione, F R
1994-11-01
Increasing public and regulatory agency concern about a variety of animal protection issues that affect the field of medicine have made these issues increasingly relevant to medical school curricula. The purpose of this study was to assess the availability and forms of medical school training relating to ethical, conceptual, and societal concerns in the use of animals within the field of medicine and the perceived need for such training. Questionnaire surveys were mailed to the Deans of the 125 accredited US medical schools, and completed by Deans or their designees within the same medical institution. Questionnaire recipients were informed that results would be compiled in a fashion that did not identify specific individuals or institutions. Survey responses were obtained from 84 medical institutions (67% response). Sixty respondents (71%) indicated that their medical school offered or sponsored some type of activity related to ethical and conceptual concerns in the use of animals in medical research and training. Most schools (43) offered informal discussions/seminars relating to these issues, but nine schools offered full formal courses with up to 15 lectures on these topics. Programme content and perceived need for additional instruction varied greatly amongst respondents. The results suggest a wide diversity amongst US medical schools in the availability and perceived importance of medical school training relating to ethical and conceptual concerns in the uses of animals in medicine. It is proposed that instruction in these areas be pursued with more concerted efforts to address the growing body of knowledge about non-human beings and the ethical implications of such knowledge.
Residential Fuel Cell Demonstration Handbook
NASA Astrophysics Data System (ADS)
Torrero, E.; McClelland, R.
2002-07-01
This report is a guide for rural electric cooperatives engaged in field testing of equipment and in assessing related application and market issues. Dispersed generation and its companion fuel cell technology have attracted increased interest by rural electric cooperatives and their customers. In addition, fuel cells are a particularly interesting source because their power quality, efficiency, and environmental benefits have now been coupled with major manufacturer development efforts. The overall effort is structured to measure the performance, durability, reliability, and maintainability of these systems, to identify promising types of applications and modes of operation, and to assess the related prospect for future use. In addition, technical successes and shortcomings will be identified by demonstration participants and manufacturers using real-world experience garnered under typical operating environments.
NASA's Hall Thruster Program 2002
NASA Technical Reports Server (NTRS)
Jankovsky, Robert S.; Jacobson, David T.; Pinero, Luis R.; Manzella, David H.; Hofer, Richard R.; Peterson, Peter Y.
2002-01-01
The NASA Hall thruster program currently supports a number of tasks related to high power thruster development for a number of customers including the Energetics Program (formerly called the Space-based Program), the Space Solar Power Program, and the In-space Propulsion Program. In program year 2002, two tasks were central to the NASA Hall thruster program: 1) the development of a laboratory Hall thruster capable of providing high thrust at high power-, and 2) investigations into operation of Hall thrusters at high specific impulse. In addition to these two primary thruster development activities, there are a number of other on-going activities supported by the NASA Hall thruster program. These additional activities are related to issues such as high-power power processor architecture, thruster lifetime, and spacecraft integration.
40 CFR 1048.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2012 CFR
2012-07-01
... § 1048.345. In addition, within 45 days after the end of the model year, you must send us a report... of all applications and any summary information you send us. (2) Any of the information we specify in... tests (such as test cell temperatures and relative humidity readings) for one year after we issue the...
40 CFR 1048.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2014 CFR
2014-07-01
... § 1048.345. In addition, within 45 days after the end of the model year, you must send us a report... of all applications and any summary information you send us. (2) Any of the information we specify in... tests (such as test cell temperatures and relative humidity readings) for one year after we issue the...
40 CFR 1048.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2011 CFR
2011-07-01
... § 1048.345. In addition, within 45 days after the end of the model year, you must send us a report... of all applications and any summary information you send us. (2) Any of the information we specify in... tests (such as test cell temperatures and relative humidity readings) for one year after we issue the...
40 CFR 1048.250 - What records must I keep and make available to EPA?
Code of Federal Regulations, 2013 CFR
2013-07-01
... § 1048.345. In addition, within 45 days after the end of the model year, you must send us a report... of all applications and any summary information you send us. (2) Any of the information we specify in... tests (such as test cell temperatures and relative humidity readings) for one year after we issue the...
ERIC Educational Resources Information Center
National Association for Environmental Education, Miami, FL.
These reports are designed to provide environmental educators with the current issues in the field. Topics discussed in these papers include general environmental concerns such as environmental controls, energy policies, environmental crises and public relations, and effects of offshore drilling on the marine environment. Illustrations for the…
ERIC Educational Resources Information Center
Zane, Thomas; Carlson, Mark; Estep, David; Quinn, Mike
2013-01-01
A defining feature of autism spectrum disorders is atypical behaviors, e.g., stereotypy, noncompliance, rituals, and aggression. Deaf and hard of hearing individuals with autism present a greater challenge because of additional issues related to their hearing status. One conceptualization of problem behavior is that it serves a communication…
A Welcome Addition to the Literature: Nonpolarized Approaches to Sexual Orientation and Religiosity
ERIC Educational Resources Information Center
Phillips, Julia C.
2004-01-01
It has been fascinating to read and reflect on this set of articles, and it is my belief that the counseling field will be strengthened as a result of this major contribution. Morrow and Beckstead's (2004 [this issue]) introductory article offers a balanced overview of the history related to conversion therapy and highlights recent research and…
ERIC Educational Resources Information Center
Symes, Wendy; Humphrey, Neil
2011-01-01
Growing numbers of pupils with autistic spectrum disorders (ASD) are attending mainstream schools, and increasing numbers of additional staff are being deployed to support them. Recent research has cast doubt on the effectiveness of this support, by highlighting issues relating to deployment and training, and to relationships with class teachers.…
ERIC Educational Resources Information Center
Coops, Nicholas C.; Marcus, Jean; Construt, Ileana; Frank, Erica; Kellett, Ron; Mazzi, Eric; Munro, Alison; Nesbit, Susan; Riseman, Andrew; Robinson, John; Schultz, Anneliese; Sipos, Yona
2015-01-01
Purpose: Delivery of sustainability-related curriculum to undergraduate students can be problematic due to the traditional "siloing" of curriculum by faculties along disciplinary lines. In addition, while there is often a ready availability of courses focused on sustainability issues in the later years of students' programs, few early…
JPRS Report, Environmental Issues
1990-06-27
multilateral cooperation in addition to military -political and international legal problems. Special attention was paid to discussing measures to protect the...Aleksandr Kanishchev] [Text] Moscow June 20 TASS—Problems related to the ecological situation around Soviet military bases in Czechoslovakia have...selves—a situation in which they make little or no provision for pollution control facilities. The regulations, expected to be based on the outcome
Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-14
... the IRIS Program, EPA provides the highest quality science-based human health assessments to support... comments included in the National Academy of Sciences (NAS) 2006 report. In addition, it includes new analyses on potential human effects that may result from exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin...
Variations of Quality of Work Life of Academic Professionals in Bangladesh: A Discriminant Analysis
ERIC Educational Resources Information Center
Taher, Md. Abu
2013-01-01
Purpose: The main purpose of this research was to analyze the key issues related to quality of work life (QWL), which have become increasingly important to HRD scholars and practitioners. In addition, the significant differences between the academic professionals of public and private universities in Bangladesh in terms of QWL were also addressed.…
Hurlimann, Thierry; Peña-Rosas, Juan Pablo; Saxena, Abha; Zamora, Gerardo; Godard, Béatrice
2017-01-01
The limited integration of ethics in nutrition-related public health policies and interventions is one major concern for those who have the task of implementing them. Ethical challenges that are overlooked during the development of such interventions could raise serious ethical issues during their implementation and even after. As a result, these decision makers need technical support and ethical guidance for adaptation of interventions to local (cultural, social, economic, etc.) contexts. The goal of this scoping review is to delineate and "map" the range of ethical issues in nutrition-related public health interventions, as well as the range of the various fields in which they may arise. A scoping review of empirical research and conceptual literature was conducted following the framework of Arksey and O'Malley. Searches using PubMed with Medical Subject Headings (MeSH) categories and Advanced Search Builder as well as in the Global Health Library were performed. The final sample consists of 169 publications. The ethics of public health prevention or treatment of obesity and non-communicable diseases is the most explicitly and frequently discussed subject. In comparison, ethical issues raised by public health interventions in the fields of undernutrition, breastfeeding, vitamin/mineral supplementation and food fortification, food security, food sustainability and food safety are addressed in a lower proportion of the sample. The results illustrate the various natures, types, and scopes of existing public health nutrition-related interventions, and the various ethical issues that may be raised by these interventions, in addition to the numerous and different contexts in which they may be implemented. The ethical issues faced in the development and implementation of nutrition-related public health interventions are varied and cannot be equated with, nor generalized about, when dealing with specific activities in this field. More importantly, these ethical issues cannot be managed without a careful consideration for the complexity of contexts in which nutrition-related interventions are expected to be implemented. These interventions engage a variety of actors with diverse perspectives and interests. We discuss these challenges and also comment on the importance of considering ethical impacts in the monitoring and evaluation of such interventions. General ethical frameworks or recommendations-although useful-cannot be expected to provide policy makers, implementators and other public health personnel with sufficient practical ethical guidance as they cannot consider and anticipate the particularities of all specific nutrition-related public health interventions and the complexity of the contexts in which they are implemented. Further research is needed in order to develop more targeted ethical frameworks.
A 100-Year Review: Animal welfare in the Journal of Dairy Science-The first 100 years.
von Keyserlingk, Marina A G; Weary, Daniel M
2017-12-01
This paper outlines the history and development of research in the area of animal welfare as reflected in the 100 yr that the Journal of Dairy Science has been published. The first paper using the term "animal welfare" was published in 1983; since then (to May 2017), 244 papers that reflect growing interest regarding how farm animals are cared for have been published. Much of the scientific work to date has focused on issues related to cow health, such as lameness, and methodologically many papers use behavioral measures. In addition to this science-based research, the journal has taken on the role of publishing work of social scientists that addresses the role of the human factors relating to animal welfare, including research on citizen, consumer, and farmer attitudes toward welfare issues. We call for further research focused on societal perspectives and for new biological research focused on developing issues, such as cow-calf separation and pasture access. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.
Fisher, Marc; Albers, Gregory W; Donnan, Geoffrey A; Furlan, Anthony J; Grotta, James C; Kidwell, Chelsea S; Sacco, Ralph L; Wechsler, Lawrence R
2005-08-01
Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug efficacy and enhancing acute stroke trial design and performance. A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval. The STAIR-IV meeting had 3 main focus areas. The first topic was novel approaches to statistical design of acute stroke trials and appropriate outcome measures. The second focus was the need for better cooperation among participants in stroke therapy development that may be addressed through a national consortium of stroke trial centers in the United States and elsewhere. Lastly, regulatory issues related to the approval of novel mono and multiple acute stroke therapies were discussed. The development of additional acute stroke therapies represents a large unmet need with many remaining challenges and also opportunities to incorporate novel approaches to clinical trial design that will lead to regulatory approval. The STAIR-IV meeting explored new concepts of trial methodology and data analysis, initiatives for implementing a US clinical trialist consortium, and pertinent regulatory issues to expedite approval of novel therapies.
NASA Astrophysics Data System (ADS)
Pei, Lidan; Jin, Feifei; Ni, Zhiwei; Chen, Huayou; Tao, Zhifu
2017-10-01
As a new preference structure, the intuitionistic fuzzy linguistic preference relation (IFLPR) was recently introduced to efficiently deal with situations in which the membership and non-membership are represented as linguistic terms. In this paper, we study the issues of additive consistency and the derivation of the intuitionistic fuzzy weight vector of an IFLPR. First, the new concepts of order consistency, additive consistency and weak transitivity for IFLPRs are introduced, and followed by a discussion of the characterisation about additive consistent IFLPRs. Then, a parameterised transformation approach is investigated to convert the normalised intuitionistic fuzzy weight vector into additive consistent IFLPRs. After that, a linear optimisation model is established to derive the normalised intuitionistic fuzzy weights for IFLPRs, and a consistency index is defined to measure the deviation degree between an IFLPR and its additive consistent IFLPR. Furthermore, we develop an automatic iterative decision-making method to improve the IFLPRs with unacceptable additive consistency until the adjusted IFLPRs are acceptable additive consistent, and it helps the decision-maker to obtain the reasonable and reliable decision-making results. Finally, an illustrative example is provided to demonstrate the validity and applicability of the proposed method.
Strawhun, Jenna; Adams, Natasha; Huss, Matthew T
2013-01-01
Because the first antistalking statute was enacted in California in 1990, stalking research has been expanded immensely, yet been largely confined to exploring traditional pursuit tactics. This study instead examined the prevalence and correlates of cyberstalking behaviors while examining the phenomenon in a more inclusive manner than previous studies focusing on cyberstalking by including social networking avenues. In addition to a measure assessing cyberstalking-related behaviors, questionnaires assessing pathological aspects of personality, including attachment style, interpersonal jealousy, interpersonal violence, and anger were also provided to participants. Results indicate that, given preliminary evidence, cyberstalking-related behaviors are related to past measures of traditional stalking and cyberstalking, although prior attachment, jealousy, and violence issues within relationships are significant predictors of cyberstalking-related behaviors. In addition, unexpected gender differences emerged. For example, women admitted greater frequencies of cyberstalking perpetration than males, signaling that further research on frequency and motivation for cyberstalking among the sexes is necessary.
A diffusion of innovations model of physician order entry.
Ash, J S; Lyman, J; Carpenter, J; Fournier, L
2001-01-01
To interpret the results of a cross-site study of physician order entry (POE) in hospitals using a diffusion of innovations theory framework. Qualitative study using observation, focus groups, and interviews. Data were analyzed by an interdisciplinary team of researchers using a grounded approach to identify themes. Themes were then interpreted using classical Diffusion of Innovations (DOI) theory as described by Rogers [1]. Four high level themes were identified: organizational issues; clinical and professional issues; technology implementation issues; and issues related to the organization of information and knowledge. Further analysis using the DOI framework indicated that POE is an especially complex information technology innovation when one considers communication, time, and social system issues in addition to attributes of the innovation itself. Implementation strategies for POE should be designed to account for its complex nature. The ideal would be a system that is both customizable and integrated with other parts of the information system, is implemented with maximum involvement of users and high levels of support, and is surrounded by an atmosphere of trust and collaboration.
Disassembling archeology, reassembling the modern world.
Carruthers, William; Van Damme, Stéphane
2017-09-01
This article provides a substantive discussion of the relevance of the history of archeology to the history of science. At the same time, the article introduces the papers contained in this special issue as exemplars of this relevance. To make its case, the article moves through various themes in the history of archeology that overlap with key issues in the history of science. The article discusses the role and tension of regimes of science in antiquarian and archeological practices, and also considers issues of scale and place, particularly in relation to the field. Additionally, the piece attends to issues of professionalization and the constitution of an archeological public, at the same time as discussing issues of empire, colonialism, and the circulation of knowledge. Meanwhile, enriching discussions within and beyond the history of science, the article discusses the history of archeology and its relationship with museums, collecting, and material culture and materiality. Finally, the piece discusses the relationship of the history of archeology with wider discussions about scientific ethics. In conclusion, the article questions whether we should speak of 'the history of archeology' at all.
Laboratory Evaluation of Energy Recovery Ventilators
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kosar, D.
Over the years, building scientists have characterized the relationship between building airtightness, exhaust-only appliances airflows, and building depressurization. Now, as the use of deep retrofit measures and new construction practices is growing to realize lower infiltration levels in increasingly tighter envelopes, performance issues can arise with the operation of exhaust-only appliances in a depressurized home. As the depressurization levels climb in tighter homes, many of these exhaust-only appliances see their rated airflows reduced and other related performance issues arise as a result. If sufficiently depressurized, atmospherically vented combustion appliances that may be present in the home can backdraft as well.more » Furthermore, when exhaust-only appliances operate and the tight home becomes depressurized, water vapor intrusion from outdoors can raise additional issues of mold in the building envelope in more humid climates.« less
Disclosure 'downunder': misadventures in Australian genetic privacy law.
Bonython, Wendy; Arnold, Bruce
2014-03-01
Along with many jurisdictions, Australia is struggling with the unique issues raised by genetic information in the context of privacy laws and medical ethics. Although the consequences of disclosure of most private information are generally confined to individuals, disclosure of genetic information has far-reaching consequences, with a credible argument that genetic relatives have a right to know about potential medical conditions. In 2006, the Privacy Act was amended to permit disclosure of an individual's genetic information, without their consent, to genetic relatives, if it was to avoid or mitigate serious illness. Unfortunately, additional amendments required for operation of the disclosure amendment were overlooked. Public Interest Determinations (PIDs)-delegated legislation issued by the privacy commissioner-have, instead, been used to exempt healthcare providers from provisions which would otherwise make disclosure unlawful. This paper critiques the PIDs using documents obtained under the Freedom of Information Act-specifically the impact of both the PIDs and the disclosure amendment on patients and relatives-and confidentiality and the procedural validity of subordinate laws regulating medical privacy.
Introduction to the Special Issue on Clinical Neuropsychology of Movement Disorders.
Tröster, Alexander I
2017-11-01
The special issue on the clinical neuropsychology of movement disorders provides an overview for the non-subspecialist clinical neuropsychologist and other clinical neuroscientists of the neuropsychological features, assessment and treatment of Parkinson's disease and Lewy body dementias, atypical parkinsonian disorders (corticobasal syndrome, progressive supranuclear palsy, and multiple system atrophy), Huntington's disease, dystonia, and amyotrophic lateral sclerosis. Additionally, articles provide overviews of neuropsychological and ethical issues related to deep brain stimulation and a discussion of non-pharamcologic and non-invasive treatment of cognitive dysfunction in Parkinson's disease. A search of PubMed using neuropsycholog* and parkinson* as search terms indicates that the number of articles dealing with neuropsychology of parkinsonian disorders has more than doubled in each of the past three decades (1990-99:269 entries, 2000-09:575 entries, 2010-17:967 entries). This rapid growth of research makes a special issue on the topic very timely. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Telemedicine: legal and licensure issues
NASA Astrophysics Data System (ADS)
Wood, Michael B.; Whelan, Leo J.
1995-10-01
The National Information Infrastructure program offers a great opportunity for the United States to capitalize on remarkable technological advancements over a broad range of applications benefiting society. One such application, telemedicine, has the potential to offer widespread access to sophisticated medical care, curtailed health care delivery costs, and homogeneous health and health-related educational opportunities. However, there are a variety of barriers to widespread application of telemedicine once the technical infrastructure of the information highway is well established and ubiquitous. These barriers include technical limitations, reimbursement issues, equipment and networking costs, and appropriate scientific studies to document efficacy and cost effectiveness. These issues may prove to be only transient disincentives which can be surmounted. Additional barriers exist, however, that may not be as readily resolved by traditional methods of analysis and more widespread practice applications. These political and regulatory obstacles will require clarification of the issues and solutions based on national consensus. It is the purpose of this discussion to amplify on these particular barriers which include licensure and tort jurisdiction.
Hospital Malnutrition Related to Fasting and Underfeeding: Is It an Ethical Issue?
Arenas Moya, Diego; Plascencia Gaitán, Alejandra; Ornelas Camacho, Denisse; Arenas Márquez, Humberto
2016-06-01
Hospital malnutrition is a relevant clinical issue present in about 50% of patients that is associated with increased morbidity, mortality, and cost of care. Because of the relation of malnutrition with chronic and acute inflammatory processes secondary to disease, nutrition therapy is considered an important medical treatment. However, there is little discussion about the impact of another critical issue related to hospital malnutrition, that is, lack of appropriate food or nutrition therapy given to the patients. Unnecessary fasting practices and the use of inappropriate nutrition prescriptions result in underfeeding that can be a related or direct cause of hospital malnutrition, independent of disease or inflammatory state. Suboptimal prescription of oral, enteral, and parenteral nutrition should be analyzed and discussed from an ethical perspective since this practice has the potential to harm patients. In addition, absence or inadequate provision of nutrition may present barriers for improved patient outcomes and could be prevented by simply recognizing lack of knowledge, skills, or experience in nutrition and entrusting nutrition prescription to interdisciplinary teams with clinicians well prepared in nutrition sciences. This article reviews potential barriers to the prevention or treatment of hospital malnutrition and proposes specific actions that can help clinicians to overcome and implement optimal nutrition not just as medical therapy but also as a basic comfort care that may help patients nutritionally, clinically, physically, and emotionally. © 2016 American Society for Parenteral and Enteral Nutrition.
NASA Astrophysics Data System (ADS)
Fetisov, K. V.; Maksimov, P. V.
2018-05-01
The paper presents the application of topology optimization and laser additive manufacturing in the design of lightweight aerospace parts. At the beginning a brief overview of the topology optimization algorithm SIMP is given, one of the most commonly used algorithm in FEA software. After that, methodology of parts design with using topology optimization is discussed as well as issues related to designing for additive manufacturing. In conclusion, the practical application of the proposed methodologies is presented using the example of one complex assembly unit. As a result of the new design approach, the mass of product was reduced five times, and twenty parts were replaced by one.
Map Changes and Theme Evolution in Work Hours: A Co-Word Analysis
Liu, Bei; Chen, Hong; Huang, Xinru
2018-01-01
(1) Background: Work hours are the basic carrier impacting employees’ work–life experience and organizational performance, and employees have greater anxiety in relation to work hours as new technology requires an increasingly faster work rhythm. However, scientific research on this topic lags far behind the practice, calling to attention the need for research on work hours from the perspective of historical evolution; (2) Methods: The Bibliometric method is used to analyze the 6364 articles and their contained 77 high-frequency keywords related to work hours from the Web of Science published between 1901 and 2017. Additionally, an individual–organization–society integrative perspective was adopted to describe the map changes and theme evolution of work hours; (3) Results and conclusions: The hot spots of research at the organizational level changed significantly around 1990, with the theme of “long work hours” becoming the core issue in recent years. Studies on the individual level have gradually moved from physiological aspects to the issues of burnout and psychological distress. Research topics related to the social level are somewhat loose, and mainly focused on work–life conflict areas. In addition, the cluster analysis based on the high-frequency keywords classifies six research types according to their research themes. Based on these findings, future trends are proposed to provide theoretical and practical reference for future studies. PMID:29789455
Furukawa, Katsutoshi; Ishiki, Aiko; Tomita, Naoki; Onaka, Yuta; Saito, Haruka; Nakamichi, Tomoko; Hara, Kazunari; Kusano, Yusuke; Ebara, Masamune; Arata, Yuki; Sakota, Miku; Miyazawa, Isabelle; Totsune, Tomoko; Okinaga, Shoji; Okamura, Nobuyuki; Kudo, Yukitsuka; Arai, Hiroyuki
2016-09-01
It is well known that the brain is one of the organs particularly affected by aging in terms of function, relative to the gastrointestinal tract and liver, which exhibit less functional decline. There is also a wide range of age-related neurological disorders such as stroke, Alzheimer's disease, and Parkinson's disease. Therefore, it is very important to understand the relationship between functional age-related change and neurological dysfunction. Neuroimaging techniques including magnetic resonance imaging and positron emission tomography have been significantly improved over recent years. Many physicians and researchers have investigated various mechanisms of age-related cerebral change and associated neurological disorders using neuroimaging techniques. In this special issue of Ageing Research Reviews, we focus on cerebral- and neuro-imaging, which are a range of tools used to visualize structure, functions, and pathogenic molecules in the nervous system. In addition, we summarize several review articles about the history, present values, and future perspectives of neuroimaging modalities. Copyright © 2016 Elsevier B.V. All rights reserved.
Integrating telemedicine and telehealth: putting it all together.
Weinstein, Ronald S; Lopez, Ana Maria; Krupinski, Elizabeth A; Beinar, Sandra J; Holcomb, Michael; McNeely, Richard A; Latifi, Rifat; Barker, Gail
2008-01-01
Telemedicine and telehealth programs are inherently complex compared with their traditional on-site health care delivery counterparts. Relatively few organizations have developed sustainable, multi-specialty telemedicine programs, although single service programs, such as teleradiology and telepsychiatry programs, are common. A number of factors are barriers to the development of sustainable telemedicine and telehealth programs. First, starting programs is often challenging since relatively few organizations have, in house, a critical mass of individuals with the skill sets required to organize and manage a telemedicine program. Therefore, it is necessary to "boot strap" many of the start-up activities using available personnel. Another challenge is to assemble a management team that has time to champion telemedicine and telehealth while dealing with the broad range of issues that often confront telemedicine programs. Telemedicine programs housed within a single health care delivery system have advantages over programs that serve as umbrella telehealth organizations for multiple health care systems. Planning a telemedicine program can involve developing a shared vision among the participants, including the parent organizations, management, customers and the public. Developing shared visions can be a time-consuming, iterative process. Part of planning includes having the partnering organizations and their management teams reach a consensus on the initial program goals, priorities, strategies, and implementation plans. Staffing requirements of telemedicine and telehealth programs may be met by sharing existent resources, hiring additional personnel, or outsourcing activities. Business models, such as the Application Service Provider (ASP) model used by the Arizona Telemedicine Program, are designed to provide staffing flexibility by offering a combination of in-house and out-sourced services, depending on the needs of the individual participating health care organizations. Telemedicine programs should perform ongoing assessments of activities, ranging from service usage to quality of service assessments, to ongoing analyses of financial performance. The financial assessments should include evaluations of costs and benefits, coding issues, reimbursement, account receivables, bad debt and network utilization. Long-range strategic planning for a telemedicine and telehealth program should be carried out on an on-going basis and should include the program's governing board. This planning process should include goal setting and the periodic updating of the program's vision and mission statements. There can be additional special issues for multi-organization telemedicine and telehealth programs. For example, authority management can require the use of innovative approaches tailored to the realities of the organizational structures of the participating members. Inter-institutional relations may introduce additional issues when competing health care organizations are utilizing shared resources. Branding issues are preferably addressed during the initial planning of a multi-organizational telemedicine and telehealth program. Ideally, public policy regarding telemedicine and telehealth within a service region will complement the objectives of telemedicine and telehealth programs within that service area.
Soffer, Michal; Rimmerman, Arie
2012-06-01
This feasibility study examines the coverage of employment-related issues related to people with disabilities in the Americans with Disabilities Act of 1990. The study is a first in a series of future studies focusing on disability issues in the international economic media. A survey of 39 newspaper articles published in the Wall Street Journal, a leading and most circulated business newspaper in the USA. Specifically, it comprised articles taken from three periods: 1990, the year the Americans with Disabilities Act was enacted; 2000, a decade later; and 2008, the year the amendments were revised with respect to definitions and employment. Data were analyzed by quantitative and qualitative content analysis. The results suggest a mixed representation: a decline in negative representations of disability throughout the years alongside the emergence of a legal-fiscal discourse of a disability that depicts persons with disabilities as a fiscal burden on employers. It seems that the new image of disability presents conflicting interests between the mission of the law, promoting employers' hiring of people with disabilities, and the economic realities of accommodating them at the workplace. Additional research is needed to examine whether this image is unique to the economic media or may reflect a concern in the business community.
2013-01-01
Background The objective was to examine feasibility of using hospital discharge register data for studying fire-related injuries. Methods The Finnish National Hospital Discharge Register (FHDR) was the database used to select relevant hospital discharge data to study usability and data quality issues. Patterns of E-coding were assessed, as well as prominent challenges in defining the incidence of injuries. Additionally, the issue of defining the relevant amount of hospital days accounted for in injury care was considered. Results Directly after the introduction of the ICD-10 classification system, in 1996, the completeness of E-coding was found to be poor, but to have improved dramatically around 2000 and thereafter. The scale of the challenges to defining the incidence of injuries was found to be manageable. In counting the relevant hospital days, psychiatric and long-term care were found to be the obvious and possible sources of overestimation. Conclusions The FHDR was found to be a feasible data source for studying fire-related injuries so long as potential challenges are acknowledged and taken into account. Hospital discharge data can be a unique and powerful means for injury research as issues of representativeness and coverage of traditional probability samples can frequently be completely avoided. PMID:23496937
Masko, Meganne K
2016-01-01
Music therapists are increasingly employed by hospices. As such, they are often called upon to provide additional spiritual care to patients receiving end-of-life care. However, researchers have not yet examined the appropriateness of music therapists providing spiritual care as part of the hospice team, or ethics and training issues related to music therapist-led spiritual care. The purpose of this study was to explore the thoughts and attitudes of hospice chaplains and music therapists (MTs) about ethics and training issues related to music therapists providing spiritual care as part of the hospice interdisciplinary team. The study used semi-structured interviews with a purposive sample of music therapists and chaplains specializing in hospice care as part of a larger exploratory mixed methods study. Each interview was recorded, transcribed, and analyzed using a two-step process including both a modified phenomenological inductive approach and thematic analysis. Participants discussed ethics and training issues related to the provision of music therapist-led spiritual care as part of the hospice team. These issues included scope of practice, cultural competence and maintaining personal boundaries, and spiritual care training topics such as educational content and educational methods. While it was clear that both chaplains and music therapists felt it was appropriate for music therapists to provide spiritual care as part of the hospice team, there is a need for formal and informal spiritual care training for music therapists doing this type of work. Training should potentially include information about comparative religions, cultural competence, scope of practice, and maintaining personal boundaries. © the American Music Therapy Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-05
... Category: For a food additive petition without complex chemistry, manufacturing, efficacy, or safety issues...) Complex Category: For a food additive petition with complex chemistry, manufacturing, efficacy, and/or... additive file without complex chemistry, manufacturing, efficacy, or safety issues, the estimated time...
Emergency Medicine and the Underage Athlete
Martin, David E.
1994-01-01
Most high school and some collegiate athletes are legal minors. In civil matters, the law treats minors (usually individuals under the age of 18 years) uniquely. Limitations exist on a minor's ability to enter into contracts, make determinations regarding medical care, and bear responsibility for personal actions. Medical professionals are often unclear on matters relating to the provision of medical care to minors. The purpose of this discourse is to present selected legal issues in the context of two fictional case studies. Case 1 presents issues regarding the definition of emergency medical conditions and the related emergency medical doctrine. Case 2 provides an example of an acute medical concern which fails to fall under emergency medical classification but rather provides a context for discussing the mature minor doctrine. Both cases are analyzed in light of these doctrines in addition to other pertinent legal considerations. PMID:16558280
A theoretical framework for psychiatric nursing practice.
Onega, L L
1991-01-01
Traditionally, specific theoretical frameworks which are congruent with psychiatric nursing practice have been poorly articulated. The purpose of this paper is to identify and discuss a philosophical base, a theoretical framework, application to psychiatric nursing, and issues related to psychiatric nursing knowledge development and practice. A philosophical framework that is likely to be congruent with psychiatric nursing, which is based on the nature of human beings, health, psychiatric nursing and reality, is identified. Aaron Antonovsky's Salutogenic Model is discussed and applied to psychiatric nursing. This model provides a helpful way for psychiatric nurses to organize their thinking processes and ultimately improve the health care services that they offer to their clients. Goal setting and nursing interventions using this model are discussed. Additionally, application of the use of Antonovsky's model is made to nursing research areas such as hardiness, uncertainty, suffering, empathy and literary works. Finally, specific issues related to psychiatric nursing are addressed.
Senior Seminar Focusing on Societal Issues Related to Chemistry and Biochemistry
NASA Astrophysics Data System (ADS)
White, Harold B., III; Johnston, Murray V.; Panar, Manuel
2000-12-01
The lack of a clearly defined content or structure provided the opportunity to transform a one-credit, pass-fail senior seminar course into a meaningful capstone experience for chemistry and biochemistry majors. In addition to individual and class exercises associated with employment, graduate school, communication skills, and professional ethics, small groups of students worked together to create informative Web sites that took positions on important societal issues related to chemistry. Each group presented a seminar and responded to questions from their peers and two or more unannounced visitors, "wild cards" who often had expertise in the seminar topic. Throughout the course, the instructors placed particular emphasis on developing students' ability to work cooperatively, locate and evaluate information, make informed judgments based on available information, and logically develop and defend their positions. Input from a retired industrial chemist helped define these skill elements.
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-17
... CFR Part 63 relating to exemptions for startup, shutdown, and malfunction (SSM). On October 16, 2009, the Court issued the mandate vacating these SSM exemption provisions, which are found at 40 CFR 63.6(f... allows sources the SSM exemption as provided for in the vacated provisions at 40 CFR 63.6(f)(1) and (h)(1...
The Current State of Physics in Cuba: A Personal Perspective
NASA Astrophysics Data System (ADS)
Alonso, Marcelo
After 40 years of absence I returned twice to Cuba, in January and December of 2000, to participate as a guest lecturer in two international scientific meetings. The first dealt with physics education, and the second with current issues related to quantum mechanics. In addition to a few participants from Europe, the US and Latin America, the two meetings were well attended by Cuban physicists.
ERIC Educational Resources Information Center
International Student Pugwash, Washington, DC.
Proceedings of a symposium which focused on issues related to nuclear weapons and arms control are presented. In addition to a list of participants (including both high school and college educators) and symposium schedule, summaries/highlights of symposium sessions are provided. These include summaries of three working groups which discussed…
DOE Office of Scientific and Technical Information (OSTI.GOV)
Burtis, M.D.
This report presents abstracts (translated into English) of important Russian-language literature concerning clouds as they relate to climate change. In addition to the bibliographic citations and abstracts translated into English, this report presents the original citations and abstracts in Russian. Author and title indexes are included to assist the reader in locating abstracts of particular interest.
China-U.S. Relations: Current Issues and Implications for U.S. Policy
2006-07-14
a meeting with President Bush at the November 2004 Asia Pacific Economic Cooperation ( APEC ) meeting in ...about China’s military ambitions and its regional economic competitiveness.38 The 2005 EAS meeting represents the latest step in a trend of growing...Sino- ASEAN regional cooperation. In addition to being part of an economic partnership in the ASEAN Plus Three (APT) grouping (including
ERIC Educational Resources Information Center
Gavazzi, Stephen M.; Bostic, Jennifer M.; Lim, Ji-Young; Yarcheck, Courtney M.
2008-01-01
Faced with anywhere between one half and two thirds of its youth having a diagnosable mental illness, the identification and treatment of mental health concerns is a critically important endeavor for professionals working with youth who have contact with the juvenile justice system. In addition, the literature suggests that factors related to both…
2013-05-01
to Lack Adequate Validation Page 35 GAO-13-557 DOD Business Systems Modernization provided a compliance dashboard to document BEA...campaigns, execute marketing campaigns, and measure and evaluate the performance of marketing campaigns. Order-to- Cash Accept and process customer... dashboards reflected related GAO reports. In addition, the department’s fiscal year 2014 investment management guidance issued by the Office of the
Uehara, Ritei; Shinohara, Ryoji; Akiyama, Yuka; Ichikawa, Kaori; Ojima, Toshiyuki; Tamakoshi, Koji; Matsuura, Kencho; Yamazaki, Yoshihisa; Yamagata, Zentaro
2016-01-01
Objectives The use of maternal and child health-related information is an issue faced by the "Healthy parents and children 21" campaign, a national campaign to improve the health standards of mothers and children in Japan. This study described the current situation and issues faced by municipalities across Japan that use this information.Methods Data across municipalities selected for the current survey of promoting the "Healthy parents and children 21" campaign in 2013 were analyzed in this study. First, we chose prefectures where collected and analyzed maternal and child health-related information was provided by the municipalities. Then, we divided the municipalities according to those prefectures where the municipalities regularly reported the maternal and child health-related information and those that did not report it regularly. Finally, the characteristics about maternal and child health in those municipalities were investigated.Results Of the 47 prefectures analyzed, 35 prefectures (74.5%) collected and analyzed maternal and child health-related information provided by the municipalities. The 35 prefectures included 1,242 municipalities, of which 700 (56.4%) regularly reported maternal and child health-related information, and 542 (43.6%) did not report it regularly. The proportion of municipalities, where information about smoking during pregnancy, immunization, or low birth weight in infants was positively used, was significantly lower among municipalities that did not regularly report maternal and child health-related information than among those that regularly reported it (P<0.001). The proportion of municipalities that coordinated projects on prevention of child abuse or low birth weight in infants with the prefectures was significantly lower among municipalities that did not regularly report maternal and child health-related information than among those that regularly reported it.Conclusion Among municipalities that did not regularly report maternal and child health-related information, coordinating projects about child abuse with the prefectures might be associated with an increase in using the information. In addition to collecting and analyzing maternal and child health-related information provided by municipalities, prefectures should help municipalities coordinate projects about those issues to increase the use of the information in municipalities.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fifield, Leonard S.; Simmons, Kevin L.; Laddha, Sachin
2010-05-17
Plant-based bio-fiber has the potential to achieve weight and cost savings over glass fiber in automotive polymer composites if moisture stability and fiber-resin compatibility issues can be solved. This paper describes the compression molding of 50vol% 2 inch random nonwoven mat kenaf fiber vinyl ester composites with and without chemical resin additives intended to improve moisture stability and resin compatibility. The 2wt% addition of n-undecanoyl chloride or 10-undecenoyl chloride to the styrene-based resin prior to molding of the kenaf composites was observed to decrease the 24hr, 25oC moisture uptake of the molded panels by more than 50%. The tensile stiffnessmore » and flexural stiffness of the soaked panels containing these additives were seen to increase by more than 30% and 70%, respectively, relative to panels made with no additives. While ‘dry’ panel (50% relative humidity at 25oC) strengths did not significantly change in the presence of the additives, tensile strength was observed to increase by more than 40% and flexural strength more than doubled for the soaked panels.« less
Ding, C Y; Cao, Y; Yang, C; Sun, F; Zhan, S Y
2017-01-10
Concerns have been raised about the reporting quality in nutritional epidemiology. Therefore, strengthening the reporting of observational studies in epidemiology-nutritional epidemiology (STROBE-nut) has been proposed by extending the STROBE statement to include additional recommendations on issues related to nutritional epidemiology and dietary assessment, aiming to provide more specific guidelines on how to report observational research in the field. This paper presents a brief introduction to STROBE-nut and also an explanation of the key points in the additional items, with an example illustrating the application of the checklist.
A review of ethical issues in dementia.
Johnson, Rebecca A; Karlawish, Jason
2015-10-01
Dementia raises many ethical issues. The present review, taking note of the fact that the stages of dementia raise distinct ethical issues, focuses on three issues associated with stages of dementia's progression: (1) how the emergence of preclinical and asymptomatic but at-risk categories for dementia creates complex questions about preventive measures, risk disclosure, and protection from stigma and discrimination; (2) how despite efforts at dementia prevention, important research continues to investigate ways to alleviate clinical dementia's symptoms, and requires additional human subjects protections to ethically enroll persons with dementia; and (3) how in spite of research and prevention efforts, persons continue to need to live with dementia. This review highlights two major themes. First is how expanding the boundaries of dementias such as Alzheimer's to include asymptomatic but at-risk persons generate new ethical questions. One promising way to address these questions is to take an integrated approach to dementia ethics, which can include incorporating ethics-related data collection into the design of a dementia research study itself. Second is the interdisciplinary nature of ethical questions related to dementia, from health policy questions about insurance coverage for long-term care to political questions about voting, driving, and other civic rights and privileges to economic questions about balancing an employer's right to a safe and productive workforce with an employee's rights to avoid discrimination on the basis of their dementia risk. The review highlights these themes and emerging ethical issues in dementia.
Genetically modified crops: detection strategies and biosafety issues.
Kamle, Suchitra; Ali, Sher
2013-06-15
Genetically modified (GM) crops are increasingly gaining acceptance but concurrently consumers' concerns are also increasing. The introduction of Bacillus thuringiensis (Bt) genes into the plants has raised issues related to its risk assessment and biosafety. The International Regulations and the Codex guidelines regulate the biosafety requirements of the GM crops. In addition, these bodies synergize and harmonize the ethical issues related to the release and use of GM products. The labeling of GM crops and their products are mandatory if the genetically modified organism (GMO) content exceeds the levels of a recommended threshold. The new and upcoming GM crops carrying multiple stacked traits likely to be commercialized soon warrant sensitive detection methods both at the DNA and protein levels. Therefore, traceability of the transgene and its protein expression in GM crops is an important issue that needs to be addressed on a priority basis. The advancement in the area of molecular biology has made available several bioanalytical options for the detection of GM crops based on DNA and protein markers. Since the insertion of a gene into the host genome may even cause copy number variation, this may be uncovered using real time PCR. Besides, assessing the exact number of mRNA transcripts of a gene, correlation between the template activity and expressed protein may be established. Here, we present an overview on the production of GM crops, their acceptabilities, detection strategies, biosafety issues and potential impact on society. Further, overall future prospects are also highlighted. Copyright © 2013 Elsevier B.V. All rights reserved.
Editorial "The Interdisciplinary Nature of SOIL"
NASA Astrophysics Data System (ADS)
Brevik, E. C.; Cerdá, A.; Mataix-Solera, J.; Pereg, L.; Quinton, J. N.; Six, J.; Van Oost, K.
2014-09-01
The holistic study of soils requires an interdisciplinary approach involving biologists, chemists, geologists, and physicists amongst others, something that has been true from the earliest days of the field. This approach has been strengthened and reinforced as current research continues to use experts trained in both soil science and related fields and by the wide array of issues impacting the world's biosphere that require an in-depth understanding of soils. Of fundamental importance amongst these issues are biodiversity, biofuels/energy security, climate change, ecosystem services, food security, human health, land degradation, and water security, each representing a critical challenge for research. In order to establish a benchmark for the type of research we seek to highlight in each issue of SOIL, here in this editorial, we outline the interdisciplinary nature of soil science research that we are seeking for in SOIL, with a focus on the myriad ways soil science can be used to expand investigation into a more holistic and therefore richer approach to soil research. In addition, we provide a selection of invited review papers in the first issue of SOIL that address the study of soils and the ways in which soil investigations are essential to other related fields. We hope that both this editorial and the first issue will serve as examples of the kinds of topics we would like to see published in SOIL and will stimulate excitement among our readers and authors to participate in this new venture.
Health and Social Care workers' perceptions of NPS use in Northern Ireland.
Campbell, Anne; O Neill, Nina; Higgins, Kathryn
2017-02-01
The EU Early Warning System currently monitors more than 560 new psychoactive substances, far outweighing the total number of illicit drugs under international control. Due to the recent emergence of NPS and rapidly changing nature of the market, evidence about the way in which the emerging drugs are managed in health and social care settings is limited. The study adopted a mixed methods design, utilising a cross sectional survey and telephone interviews to capture data from staff working in drug and alcohol related services in statutory and voluntary sectors, across the five Health and Social Care (HSC) Trust areas in Northern Ireland. 196 staff participated in the survey and 13 participated in follow up in telephone interviews between August and November 2015. Study respondents reported that addressing NPS related issues with service users was a key aspect of their daily role and function. Levels of injecting behaviours were also viewed as relatively high by study participants. Almost all workers used harm reduction as their primary approach when working with service users and the majority of respondents called for additional practical training in relation to addressing drug interactions and intervening with NPS related issues. Copyright © 2016 Elsevier B.V. All rights reserved.
Biophysical Technologies for Management of Wound Bioburden
Korzendorfer, Holly; Hettrick, Heather
2014-01-01
Significance: Chronic wounds commonly have high levels of bioburden and antibiotic-resistant pathogens. This review article focuses on findings from current literature related to four biophysical technologies (ultrasound, electrical stimulation, phototherapy, and negative pressure wound therapy) believed to be beneficial for managing wound bioburden and support healing. Recent Advances and Critical Issues: Recent advances for each modality are provided as a basic synopsis of the technology followed by brief overviews of the most recent literature addressing its effectiveness for managing wound bioburden, and critical issues for each modality are provided as conclusions. Future Directions: This review highlights the need for further clinically relevant studies examining bacterial levels in addition to healing progression for each technology. PMID:25493207
DeRanieri, Joseph T; Clements, Paul T; Clark, Kathleen; Kuhn, Douglas Wolcik; Manno, Martin S
2004-04-01
Many caregivers are encountering the issue of communicating with children and adolescents about current world events, specifically war and terrorism. As health care providers, it is important to raise awareness of how children may understand, interpret, and respond to related fears and concerns. Although honesty and reassurance are clearly the best approach, it is important to provide information that is developmentally appropriate. Providing education and guidance can reduce stress and enhance understanding of the chaotic events confronting our nation. It also provides a platform for communication and exploration should additional terrorist attacks or acts of war occur. It is important to examine how to approach children and adolescents to communicate with them about these sensitive issues.
Code of Federal Regulations, 2013 CFR
2013-04-01
... regulations; deceptive use of a color additive for which a regulation has issued. 71.22 Section 71.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE... regulation for a color additive authorizing its use generally in or on a food, drug, or cosmetic shall not be...
Code of Federal Regulations, 2012 CFR
2012-04-01
... regulations; deceptive use of a color additive for which a regulation has issued. 71.22 Section 71.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE... regulation for a color additive authorizing its use generally in or on a food, drug, or cosmetic shall not be...
Code of Federal Regulations, 2014 CFR
2014-04-01
... regulations; deceptive use of a color additive for which a regulation has issued. 71.22 Section 71.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE... regulation for a color additive authorizing its use generally in or on a food, drug, or cosmetic shall not be...
Code of Federal Regulations, 2010 CFR
2010-04-01
... regulations; deceptive use of a color additive for which a regulation has issued. 71.22 Section 71.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL COLOR ADDITIVE... regulation for a color additive authorizing its use generally in or on a food, drug, or cosmetic shall not be...
PET/CT Assessment of Response to Therapy: Tumor Change Measurement, Truth Data, and Error1
Kinahan, Paul E; Doot, Robert K; Wanner-Roybal, Michelle; Bidaut, Luc M; Armato, Samuel G; Meyer, Charles R; McLennan, Geoffrey
2009-01-01
We describe methods and issues that are relevant to the measurement of change in tumor uptake of 18F-fluorodeoxyglucose (FDG) or other radiotracers, as measured from positron emission tomography/computed tomography (PET/CT) images, and how this would relate to the establishment of PET/CT tumor imaging as a biomarker of patient response to therapy. The primary focus is on the uptake of FDG by lung tumors, but the approach can be applied to diseases other than lung cancer and to tracers other than FDG. The first issue addressed is the sources of bias and variance in the measurement of tumor uptake of FDG, and where there are still gaps in our knowledge. These are discussed in the context of measurement variation and how these would relate to the early detection of response to therapy. Some of the research efforts currently underway to identify the magnitude of some of these sources of error are described. In addition, we describe resources for these investigations that are being made available through the Reference Image Database for the Evaluation of Response project. Measures derived from PET image data that might be predictive of patient response as well as the additional issues that each of these metrics may encounter are described briefly. The relationship between individual patient response to therapy and utility for multicenter trials is discussed. We conclude with a discussion of moving from assessing measurement variation to the steps necessary to establish the efficacy of PET/CT imaging as a biomarker for response. PMID:19956382
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-04
... reports received of additional causes of HPT rotor imbalance not addressed in AD 2010-12-10, and two additional LPT rotor stage 3 disk events. We are issuing this AD to prevent critical life-limited rotating... issued. We issued those ADs to prevent critical life-limited rotating engine part failure, which could...
Psychoanalysis and the nuclear threat
DOE Office of Scientific and Technical Information (OSTI.GOV)
Levine, H.B.; Jacobs, D.; Rubin, L.J.
1988-01-01
{ital Psychoanalysis and the Nuclear Threat} provides coverage of the dynamic and clinical considerations that follow from life in the nuclear age. Of special clinical interest are chapters dealing with the developmental consequences of the nuclear threat in childhood, adolescence, and adulthood, and those exploring the technical issues raised by the occurrence in analytic and psychotherapeutic hours of material related to the nuclear threat. Additional chapters bring a psychoanalytic perspective to bear on such issues as the need to have enemies, silence as the real crime, love, work, and survival in the nuclear age, the relationship of the nuclear threatmore » to issues of mourning and melancholia, apocalyptic fantasies, the paranoid process, considerations of the possible impact of gender on the nuclear threat, and the application of psychoanalytic thinking to nuclear arms strategy. Finally, the volume includes the first case report in the English language---albeit a brief psychotherapy---involving the treatment of a Hiroshima survivor.« less
Barrett, Annette; Terry, Daniel R; Lê, Quynh; Hoang, Ha
2016-02-01
This review sought to better understand the issues and challenges experienced by community nurses working in rural areas and how these factors shape their role. Databases were searched to identify relevant studies, published between 1990 and 2015, that focussed on issues and challenges experienced by rural community nurses. Generic and grey literature relating to the subject was also searched. The search was systematically conducted multiple times to assure accuracy. A total of 14 articles met the inclusion criteria. This critical review identified common issues impacting community nursing and included role definition, organisational change, human resource, workplace and geographic challenges. Community nurses are flexible, autonomous, able to adapt care to the service delivery setting, and have a diversity of knowledge and skills. Considerably more research is essential to identify factors that impact rural community nursing practice. In addition, greater advocacy is required to develop the role.
Privacy Is Become with, Data Perturbation
NASA Astrophysics Data System (ADS)
Singh, Er. Niranjan; Singhai, Niky
2011-06-01
Privacy is becoming an increasingly important issue in many data mining applications that deal with health care, security, finance, behavior and other types of sensitive data. Is particularly becoming important in counterterrorism and homeland security-related applications. We touch upon several techniques of masking the data, namely random distortion, including the uniform and Gaussian noise, applied to the data in order to protect it. These perturbation schemes are equivalent to additive perturbation after the logarithmic Transformation. Due to the large volume of research in deriving private information from the additive noise perturbed data, the security of these perturbation schemes is questionable Many artificial intelligence and statistical methods exist for data analysis interpretation, Identifying and measuring the interestingness of patterns and rules discovered, or to be discovered is essential for the evaluation of the mined knowledge and the KDD process as a whole. While some concrete measurements exist, assessing the interestingness of discovered knowledge is still an important research issue. As the tool for the algorithm implementations we chose the language of choice in industrial world MATLAB.
Non-dairy probiotic food products: An emerging group of functional foods.
Min, Min; Bunt, Craig R; Mason, Susan L; Hussain, Malik A
2018-04-09
The functional food sector has shown tremendous growth in recent years with the application of probiotic bacteria as "food additives". The utilization of probiotic bacteria in food presents many challenges related to their growth, survival, viability, stability and functionality in food processing, storage and consumption as well as changes of sensory characteristics of probiotic foods. Although dairy foods are currently the most common food carrier to deliver probiotics, an increasing number of non-dairy food matrices exhibit potential for delivery of probiotics. This review provides more recent insight into the emergence of non-dairy probiotics products, the interactions between probiotics and different food matrices and the challenges in developing such products. Some of the technical issues are also reviewed and discussed. These issues include the efficacy of probiotic bacteria in non-chilled, low pH or high water activity foods; the potential loss of bacterial viability, additionally unwanted fermentation and changes of the sensory characteristics of food products which may result in poor microbiological quality and low acceptability to consumers.
Food additives used in meat processing according to the Polish and European Union legislation.
Uradziński, J; Weiner, M
2003-01-01
This paper presents the legal regulations related to the use of food additives in meat production in Poland and the European Union. The Polish legal definition of food additives is given as well as the classification of permitted food additives added to food and stimulants by their technological function. In addition, a definition of processing aids in the food industry is included. It shows that Polish legislation includes food additives used to ensure or improve food nutritional value, whereas in the EU legislation, these substances are not included in the list of food additives. Moreover, the Council Directives include food additive specific purity criteria, whereas the Polish regulations do not mention the legal regulations of this issue in practice. The European Union use mechanisms and procedures for the introduction of new food additives into internal markets as well as controlling the circulation of additives. The Polish legislation in practice, however, does not determine approval or methods for the introduction of new food additives to the market. Legal regulations on the monitoring of food additives no exist.
Peña-Rosas, Juan Pablo; Saxena, Abha; Zamora, Gerardo
2017-01-01
Background The limited integration of ethics in nutrition-related public health policies and interventions is one major concern for those who have the task of implementing them. Ethical challenges that are overlooked during the development of such interventions could raise serious ethical issues during their implementation and even after. As a result, these decision makers need technical support and ethical guidance for adaptation of interventions to local (cultural, social, economic, etc.) contexts. Aim The goal of this scoping review is to delineate and “map” the range of ethical issues in nutrition-related public health interventions, as well as the range of the various fields in which they may arise. Methods A scoping review of empirical research and conceptual literature was conducted following the framework of Arksey and O’Malley. Searches using PubMed with Medical Subject Headings (MeSH) categories and Advanced Search Builder as well as in the Global Health Library were performed. The final sample consists of 169 publications. Results The ethics of public health prevention or treatment of obesity and non-communicable diseases is the most explicitly and frequently discussed subject. In comparison, ethical issues raised by public health interventions in the fields of undernutrition, breastfeeding, vitamin/mineral supplementation and food fortification, food security, food sustainability and food safety are addressed in a lower proportion of the sample. The results illustrate the various natures, types, and scopes of existing public health nutrition-related interventions, and the various ethical issues that may be raised by these interventions, in addition to the numerous and different contexts in which they may be implemented. Discussion The ethical issues faced in the development and implementation of nutrition-related public health interventions are varied and cannot be equated with, nor generalized about, when dealing with specific activities in this field. More importantly, these ethical issues cannot be managed without a careful consideration for the complexity of contexts in which nutrition-related interventions are expected to be implemented. These interventions engage a variety of actors with diverse perspectives and interests. We discuss these challenges and also comment on the importance of considering ethical impacts in the monitoring and evaluation of such interventions. Conclusion General ethical frameworks or recommendations–although useful–cannot be expected to provide policy makers, implementators and other public health personnel with sufficient practical ethical guidance as they cannot consider and anticipate the particularities of all specific nutrition-related public health interventions and the complexity of the contexts in which they are implemented. Further research is needed in order to develop more targeted ethical frameworks. PMID:29073186
Intermittent Renewable Management Pilot Phase 2
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kiliccote, Sila; Homan, Gregory; Anderson, Robert
The Intermittent Renewable Management Pilot - Phase 2 (IRM2) was designed to study the feasibility of demand-side resources to participate into the California Independent System Operator (CAISO) wholesale market as proxy demand resources (PDR). The pilot study focused on understanding the issues related with direct participation of third-parties and customers including customer acceptance; market transformation challenges (wholesale market, technology); technical and operational feasibility; and value to the rate payers, DR resource owners and the utility on providing an enabling mechanism for DR resources into the wholesale markets. The customer had the option of committing to either three contiguous hour blocksmore » for 24 days or six contiguous hours for 12 days a month with day-ahead notification that aligned with the CAISO integrated forward market. As a result of their being available, the customer was paid $10/ kilowatt (kW)-month for capacity in addition to CAISO energy settlements. The participants were limited to no more than a 2 megawatt (MW) capacity with a six-month commitment. Four participants successfully engaged in the pilot. In this report, we provide the description of the pilot, participant performance results, costs and value to participants as well as outline some of the issues encountered through the pilot. Results show that participants chose to participate with storage and the value of CAISO settlements were significantly lower than the capacity payments provided by the utility as incentive payments. In addition, this pilot revealed issues both on the participant side and system operations side. These issues are summarized in the report.The Intermittent Renewable Management Pilot - Phase 2 (IRM2) was designed to study the feasibility of demand-side resources to participate into the California Independent System Operator (CAISO) wholesale market as proxy demand resources (PDR). The pilot study focused on understanding the issues related with direct participation of third-parties and customers including customer acceptance; market transformation challenges (wholesale market, technology); technical and operational feasibility; and value to the rate payers, DR resource owners and the utility on providing an enabling mechanism for DR resources into the wholesale markets.« less
The Today and Likely Tomorrow of American Race Relations
ERIC Educational Resources Information Center
Ashmore, Richard D.
1976-01-01
An introduction to a Special issue of the Journal of Social Issues (JSI) by the guest editor, which reviews psychology's concerns with race relations and race related issues during the fifties, sixties and seventies, summarizes past JSI issues pertinent to those issues, and introduces the ten articles in this issue. (Author/JM)
Cheng, Sheung-Tak; Lau, Rosanna W L; Mak, Emily P M; Ng, Natalie S S; Lam, Linda C W
2014-12-01
To describe an intervention promoting benefit-finding in Alzheimer caregivers, to discuss key issues in implementation and ways to resolve them, and to examine whether the intervention reduced burden and depression in a small randomized trial. Twenty-five caregivers were randomized into benefit-finding and psychoeducation groups. Both groups had eight weekly sessions. Outcome measures including role overload, Zarit Burden Interview, and Hamilton depression scale were collected at baseline and after treatment. Results were analyzed using analysis of covariance. Additionally, the challenges of implementing such interventions, some of which related to cultural issues, were analyzed qualitatively. Controlling for pretest, the benefit-finding group had lower depression than the psychoeducation group at post-test, despite the fact that some caregivers found benefit-finding challenging. The two groups did not differ on overload and burden. However, within-group analysis suggested that both groups showed significant reductions in overload from pretest to post-test. In addition, we discussed participants' difficulties in grasping the technique of thought modification for benefit-finding, recording such exercises at home, and sharing their thoughts and experiences in groups. We described measures undertaken in the main trial to overcome these issues. Cognitive approaches focusing on benefit-finding are feasible among Chinese caregivers, with preliminary evidence suggesting an effect on alleviating depression. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Strayer, David L; Cooper, Joel M
2015-12-01
We address several themes that emerged in the commentaries related to our target article. First, we consider the relationship between cognitive distraction and crash risk. Second, we discuss the development of our cognitive distraction scale. Third, we weigh issues of self-regulation, appropriate baselines, and satisficing. Finally, we identify several areas where additional research is needed to refine our understanding of driver distraction and crash risk. © 2015, Human Factors and Ergonomics Society.
Evolution of Ada technology in the flight dynamics area: Implementation/testing phase analysis
NASA Technical Reports Server (NTRS)
Quimby, Kelvin L.; Esker, Linda; Miller, John; Smith, Laurie; Stark, Mike; Mcgarry, Frank
1989-01-01
An analysis is presented of the software engineering issues related to the use of Ada for the implementation and system testing phases of four Ada projects developed in the flight dynamics area. These projects reflect an evolving understanding of more effective use of Ada features. In addition, the testing methodology used on these projects has changed substantially from that used on previous FORTRAN projects.
Application of the Chimera overlapped grid scheme to simulation of Space Shuttle ascent flows
NASA Technical Reports Server (NTRS)
Buning, Pieter G.; Parks, Steven J.; Chan, William M.; Renze, Kevin J.
1992-01-01
Several issues relating to the application of Chimera overlapped grids to complex geometries and flowfields are discussed. These include the addition of geometric components with different grid topologies, gridding for intersecting pieces of geometry, and turbulence modeling in grid overlap regions. Sample results are presented for transonic flow about the Space Shuttle launch vehicle. Comparisons with wind tunnel and flight measured pressures are shown.
On the minimization properties of Tisserand systems
NASA Astrophysics Data System (ADS)
Escapa, A.; Baenas, T.; Ferrándiz, J.; Getino, J.
2015-08-01
Tisserand systems are a useful concept to model the rotation of deformable sets of particles. They can be characterized by means of three alternative conditions related with the angular momentum and kinetic energy of the set. In this note, we revisit the issue providing a new proof of the equivalence between some of these defining conditions. In addition, we determine the time evolution of Tisserand systems in a clear way.
Main Chamber and Preburner Injector Technology
NASA Technical Reports Server (NTRS)
Santoro, Robert J.; Merkle, Charles L.
1999-01-01
This document reports the experimental and analytical research carried out at the Penn State Propulsion Engineering Research Center in support of NASA's plan to develop advanced technologies for future single stage to orbit (SSTO) propulsion systems. The focus of the work is on understanding specific technical issues related to bi-propellant and tri-propellant thrusters. The experiments concentrate on both cold flow demonstrations and hot-fire uni-element tests to demonstrate concepts that can be incorporated into hardware design and development. The analysis is CFD-based and is intended to support the design and interpretation of the experiments and to extrapolate findings to full-scale designs. The research is divided into five main categories that impact various SSTO development scenarios. The first category focuses on RP-1/gaseous hydrogen (GH2)/gaseous oxygen (GO2) tri-propellant combustion with specific emphasis on understanding the benefits of hydrogen addition to RP-1/oxygen combustion and in developing innovative injector technology. The second category investigates liquid oxygen (LOX)/GH2 combustion at main chamber near stoichiometric conditions to improve understanding of existing LOX/GH2 rocket systems. The third and fourth categories investigate the technical issues related with oxidizer-rich and fuel-rich propulsive concepts, issues that are necessary for developing the full-flow engine cycle. Here, injector technology issues for both LOX/GH2 and LOX/RP-1 propellants are examined. The last category, also related to the full-flow engine cycle, examines injector technology needs for GO2/GH2 propellant combustion at near-stoichiometric conditions for main chamber application.
Advantages and Challenges of Radiative Liquid Lithium Divertor
NASA Astrophysics Data System (ADS)
Ono, Masayuki
2017-10-01
Steady-state fusion power plant designs present major divertor technology challenges, including high divertor heat flux both in steady-state and during transients. In addition to these concerns, there are the unresolved technology issues of long term dust accumulation and associated tritium inventory and safety issues. The application of lithium (Li) in NSTX resulted in improved H-mode confinement, H-mode power threshold reduction, and reduction in the divertor peak heat flux while maintaining essentially Li-free core plasma operation even during H-modes. These promising results in NSTX and related modeling calculations motivated the radiative liquid Li divertor (RLLD) concept and its variant, the active liquid Li divertor concept (ARLLD), taking advantage of the enhanced Li radiation in relatively poorly confined divertor plasmas. It has been suggested that radiation-based liquid lithium (LL) divertor concepts with a modest Li-loop could provide a possible solution for the outstanding fusion reactor technology issues such as divertor heat flux mitigation and real time dust removal, while potentially improving the reactor plasma performance. Laboratory tests are also planned to investigate the Li-T recover efficiency and other relevant research topics of the RLLD. This work supported by DoE Contract No. DE-AC02-09CH11466.
Scope of Policy Issues in eHealth: Results From a Structured Literature Review
Durrani, Hammad; Nayani, Parvez; Fahim, Ammad
2012-01-01
Background eHealth is widely used as a tool for improving health care delivery and information. However, distinct policies and strategies are required for its proper implementation and integration at national and international levels. Objective To determine the scope of policy issues faced by individuals, institutions, or governments in implementing eHealth programs. Methods We conducted a structured review of both peer-reviewed and gray literature from 1998–2008. A Medline search for peer-reviewed articles found 40 papers focusing on different aspects of eHealth policy. In addition, a Google search found 20 national- and international-level policy papers and documents. We reviewed these articles to extract policy issues and solutions described at different levels of care. Results The literature search found 99 policy issues related to eHealth. We grouped these issues under the following themes: (1) networked care, (2) interjurisdictional practice, (3) diffusion of eHealth/digital divide, (4) eHealth integration with existing systems, (5) response to new initiatives, (6) goal-setting for eHealth policy, (7) evaluation and research, (8) investment, and (9) ethics in eHealth. Conclusions We provide a list of policy issues that should be understood and addressed by policy makers at global, jurisdictional, and institutional levels, to facilitate smooth and reliable planning of eHealth programs. PMID:22343270
Nuclear safety for the space exploration initiative
NASA Technical Reports Server (NTRS)
Dix, Terry E.
1991-01-01
The results of a study to identify potential hazards arising from nuclear reactor power systems for use on the lunar and Martian surfaces, related safety issues, and resolutions of such issues by system design changes, operating procedures, and other means are presented. All safety aspects of nuclear reactor power systems from prelaunch ground handling to eventual disposal were examined consistent with the level of detail for SP-100 reactor design at the 1988 System Design Review and for launch vehicle and space transport vehicle designs and mission descriptions as defined in the 90-day Space Exploration Initiative (SEI) study. Information from previous aerospace nuclear safety studies was used where appropriate. Safety requirements for the SP-100 space nuclear reactor system were compiled. Mission profiles were defined with emphasis on activities after low earth orbit insertion. Accident scenarios were then qualitatively defined for each mission phase. Safety issues were identified for all mission phases with the aid of simplified event trees. Safety issue resolution approaches of the SP-100 program were compiled. Resolution approaches for those safety issues not covered by the SP-100 program were identified. Additionally, the resolution approaches of the SP-100 program were examined in light of the moon and Mars missions.
Unique Construction and Social Experiences in Residential Remediation Sites - 13423
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jung, Paul; Scarborough, Rebecca
2013-07-01
Sevenson Environmental Services, Inc., (Sevenson) has performed several radiological remediation projects located in residential urban areas. Over the course of these projects, there has been a wide variety of experiences encountered from construction related issues to unique social situations. Some of the construction related issues included the remediation of interior basements where contaminated material was located under the footers of the structure or was used in the mortar between cinder block or field stone foundations. Other issues included site security, maintaining furnaces or other utilities, underpinning, backfilling and restoration. In addition to the radiological hazards associated with this work theremore » were occupational safety and industrial hygiene issues that had to be addressed to ensure the safety and health of neighboring properties and residents. The unique social situations at these job sites have included arson, theft/stolen property, assault/battery, prostitution, execution of arrest warrants for residents, discovery of drugs and paraphernalia, blood borne pathogens, and unexploded ordnance. Some of these situations have become a sort of comical urban legend throughout the organization. One situation had historical significance, involving the demolition of a house to save a tree older than the Declaration of Independence. All of these projects typically involve the excavation of early 20. century items such as advertisement signs, various old bottles (milk, Listerine, perfume, whisky) and other miscellaneous common trash items. (authors)« less
Plumlee, Geoffrey S.; Morton, Robert A.; Boyle, Terence P.; Medlin, Jack H.; Centeno, Jose A.
2000-01-01
This report summarizes results of a visit by the report authors to Marinduque Island, Philippines, in May 2000. The purpose of the visit was to conduct a preliminary examination of environmental problems created by a 1996 tailings spill from the Marcopper open-pit copper mine. The mine was operated from 1969-1996 by Macropper Mining Corperation, under 39.9% ownership, and design and management control of Placer Dome, Inc. Our trip expenses to and from the Philippines were funded by the USGS. In-country expenses were paid by the offices of Congressman Reyes and the Governor of Marinduque, Carmencita O. Reyes. This report includes observations we made based on our relatively short visit to the island, and observations based upon a preliminary review of the literature available on the islanda??s mining-environmental issues. In addition, we have included preliminary interpretations and analytical results of some water, sediment, and mine waste samples collected during our trip. We also highlight the environmental and human health issues we fell are in need of further study and consideration for mitigation or remediation. This report is preliminary and is not intended to be a comprehensive or final review of the islanda??s mining-environmental issues; many areas of further study are clearly neededa?|
Feasibility study for early removal of HEU from CPP-651-Phase II
DOE Office of Scientific and Technical Information (OSTI.GOV)
Smith, C.V.; Henry, R.; Milligan, C.
1997-09-01
A two-phase feasibility study was initiated in late 1996 to identify a way to expedite the removal of SNM from the CPP-651 vault. The first phase of this study provided preliminary information that appeared promising, but needed additional detailed planning and evaluate to validate the concepts and conclusions. The focus of Phase 2 was to provide the validation via resource-loaded schedules and more detailed cost estimates. Section 1 describes the purpose and objectives of the Phase 2 tasks and the programmatic drivers that influence related CPP-651 high-enriched uranium (HEU) management issues. Section 2 identifies the evaluation criteria and methodology andmore » the transfer issues and barriers preventing shipment. Section 3 provides site-specific background information for the CPP-651 facility and the Idaho National Engineering and Environmental Laboratory (INEEL) and describes the development of the basic material removal schedule, the proposed base case plan for removal of SNM, and the proposed HEU material management/shipping issues and strategies. Section 4 identifies the proposed options for accelerated removal of SNM and how they were evaluated via detailed scheduling, resource histograms, and cost analysis. Section 5 summarizes principal tasks for implementing this plan and other related HEU CPP-651 management issues that require continued planning efforts to assure successful implementation of this proposed early removal strategy.« less
Determination of urine-derived odorous compounds in a source separation sanitation system.
Liu, Bianxia; Giannis, Apostolos; Chen, Ailu; Zhang, Jiefeng; Chang, Victor W C; Wang, Jing-Yuan
2017-02-01
Source separation sanitation systems have attracted more and more attention recently. However, separate urine collection and treatment could induce odor issues, especially in large scale application. In order to avoid such issues, it is necessary to monitor the odor related compounds that might be generated during urine storage. This study investigated the odorous compounds that emitted from source-separated human urine under different hydrolysis conditions. Batch experiments were conducted to investigate the effect of temperature, stale/fresh urine ratio and urine dilution on odor emissions. It was found that ammonia, dimethyl disulfide, allyl methyl sulfide and 4-heptanone were the main odorous compounds generated from human urine, with headspace concentrations hundreds of times higher than their respective odor thresholds. Furthermore, the high temperature accelerated urine hydrolysis and liquid-gas mass transfer, resulting a remarkable increase of odor emissions from the urine solution. The addition of stale urine enhanced urine hydrolysis and expedited odor emissions. On the contrary, diluted urine emitted less odorous compounds ascribed to reduced concentrations of odorant precursors. In addition, this study quantified the odor emissions and revealed the constraints of urine source separation in real-world applications. To address the odor issue, several control strategies are recommended for odor mitigation or elimination from an engineering perspective. Copyright © 2016. Published by Elsevier B.V.
[Confronting the Health-Related Challenges of Climate Change: Nursing Education for the Future].
Wu, Pei-Chih; Lee, Chi-Chen
2016-08-01
Climate change is the greatest threat to public health in the 21st century. The increasing health impact of heat waves, the increasing magnitudes and spatial expansions of vector and water-borne diseases epidemics, and the increasing medical burdens of biological allergic illnesses, worsening local air pollution, and other related issues are expected to continue to increase in severity in the near future. All of these issues are global problems that must be faced. Adaptation strategies and action plans related to climate change are needed and emerging. Moreover, integrating the basic concepts, scientific evidences, and new technology into public and professional education systems is already recognized as a priority in the national adaptation program. Nurses stand on the frontlines of medical care and health communication. The integration of climate change and adaptation to climate change into nursing education and training is become increasingly important. This article reviews both the expected health impacts of climate change and the mitigation and adaptation strategies that have been proposed / adopted by medical care facilities around the world. Further, we outline the current, priority needs for action in medical care facilities in Taiwan in order to mitigate and adapt to climate-change-related healthcare issues. Additionally, we present an integrated strategic plan for educating healthcare professionals, including nurse, in the future. We hope that the ideas that are presented in this paper encourage multidisciplinary cooperation and help bridge the gap between technology development and practical application in Taiwan's medical care system.
Brown, Jean K; Byers, Tim; Doyle, Colleen; Coumeya, Kerry S; Demark-Wahnefried, Wendy; Kushi, Lawrence H; McTieman, Anne; Rock, Cheryl L; Aziz, Noreen; Bloch, Abby S; Eldridge, Barbara; Hamilton, Kathryn; Katzin, Carolyn; Koonce, Amy; Main, Julie; Mobley, Connie; Morra, Marion E; Pierce, Margaret S; Sawyer, Kimberly Andrews
2003-01-01
Cancer survivors are often highly motivated to seek information about food choices, physical activity, dietary supplement use, and complementary nutritional therapies to improve their treatment outcomes, quality of life, and survival. To address these concerns, the American Cancer Society (ACS) convened a group of experts in nutrition, physical activity, and cancer to evaluate the scientific evidence and best clinical practices related to optimal nutrition and physical activity after the diagnosis of cancer. This report summarizes their findings and is intended to present health care providers with the best possible information on which to help cancer survivors and their families make informed choices related to nutrition and physical activity. The report discusses nutrition and physical activity issues during the phases of cancer treatment and recovery, living after recovery from treatment, and living with advanced cancer; selected nutritional and physical activity issues such as body weight, food choices, and complementary and alternative nutritional options; and selected issues related to breast, colorectal, lung, prostate, head and neck, and upper gastrointestinal cancers. In addition, handouts containing commonly asked questions and answers and a resource list are provided for survivors and families. Tables that grade the scientific evidence for benefit versus harm related to nutrition and physical activity for breast, colorectal, lung, and prostate cancers are also included for this growing body of knowledge to provide guidance for informed decision making and to identify areas for future research.
Bodai, Balazs I; Tuso, Phillip
2015-01-01
Long-term survival rates after a diagnosis of breast cancer are steadily rising. This is good news, but clinicians must also recognize that this brings new challenges to the medical community. As breast cancer becomes a chronic condition rather than a life-threatening illness owing to advances in early diagnosis and more effective treatments, health care practitioners must recognize and manage the long-term sequelae of the constellation of therapeutic modalities. Survivors of breast cancer represent a unique and extremely complex group of patients; not only do they have the challenge of dealing with multiple long-term side effects of treatment protocols, but many are also forced to address the preexisting comorbidities of their therapies, which often include multiple other issues. Therapies have additional and/or additive side effects that may interfere with treatments directed toward the new primary diagnosis of breast cancer. Our mandate is to establish a smooth transition from patient with breast cancer to survivor of breast cancer while providing ongoing and future guidance. Certainly, the information and resources to accomplish this transition are readily available; however, they are scattered throughout the literature and therefore are not easily accessible or available to the primary care physician. It is imperative that the information available regarding survivorship issues be accessible in an organized and useful format. This article is a modest attempt to provide a comprehensive review of the long-term medical issues relevant to survivorship after the diagnosis and treatment of breast cancer. A predicted shortage of oncologists by 2020 is well-recognized. Therefore, the bulk of long-term care will become dependent on the primary care physician. This shift of care means that these physicians will need to be well educated in the long-term medical issues related to breast cancer treatment. PMID:25902343
Supporting cancer patients in illness management: usability evaluation of a mobile app.
Mirkovic, Jelena; Kaufman, David R; Ruland, Cornelia M
2014-08-13
Mobile phones and tablets currently represent a significant presence in people's everyday lives. They enable access to different information and services independent of current place and time. Such widespread connectivity offers significant potential in different app areas including health care. Our goal was to evaluate the usability of the Connect Mobile app. The mobile app enables mobile access to the Connect system, an online system that supports cancer patients in managing health-related issues. Along with symptom management, the system promotes better patient-provider communication, collaboration, and shared decision making. The Connect Mobile app enables access to the Connect system over both mobile phones and tablets. The study consisted of usability tests of a high fidelity prototype with 7 cancer patients where the objectives were to identify existing design and functionality issues and to provide patients with a real look-and-feel of the mobile system. In addition, we conducted semistructured interviews to obtain participants' feedback about app usefulness, identify the need for new system features and design requirements, and measure the acceptance of the mobile app and its features within everyday health management. The study revealed a total of 27 design issues (13 for mobile apps and 14 for tablet apps), which were mapped to source events (ie, errors, requests for help, participants' concurrent feedback, and moderator observation). We also applied usability heuristics to identify violations of usability principles. The majority of violations were related to enabling ease of input, screen readability, and glanceability (15 issues), as well as supporting an appropriate match between systems and the real world (7 issues) and consistent mapping of system functions and interactions (4 issues). Feedback from participants also showed the cancer patients' requirements for support systems and how these needs are influenced by different context-related factors, such as type of access terminal (eg, desktop computer, tablet, mobile phone) and phases of illness. Based on the observed results, we proposed design and functionality recommendations that can be used for the development of mobile apps for cancer patients to support their health management process. Understanding and addressing users' requirements is one of the main prerequisites for developing useful and effective technology-based health interventions. The results of this study outline different user requirements related to the design of the mobile patient support app for cancer patients. The results will be used in the iterative development of the Connect Mobile app and can also inform other developers and researchers in development, integration, and evaluation of mobile health apps and services that support cancer patients in managing their health-related issues.
Space Station Engineering Design Issues
NASA Technical Reports Server (NTRS)
Mcruer, Duane T.; Boehm, Barry W.; Debra, Daniel B.; Green, C. Cordell; Henry, Richard C.; Maycock, Paul D.; Mcelroy, John H.; Pierce, Chester M.; Stafford, Thomas P.; Young, Laurence R.
1989-01-01
Space Station Freedom topics addressed include: general design issues; issues related to utilization and operations; issues related to systems requirements and design; and management issues relevant to design.
First year of AIDS services delivery under Title I of the Ryan White CARE Act.
Bowen, G S; Marconi, K; Kohn, S; Bailey, D M; Goosby, E P; Shorter, S; Niemcryk, S
1992-01-01
This is a review of (a) the emergency assistance for ambulatory HIV medical and support services provided in the first year by eligible metropolitan areas (EMAs) funded under Title I of the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act of 1990, (b) the varied responses and processes by which the 16 urban areas receiving Title I funds in 1991 met legislative mandates, (c) the central nature of planning councils under Title I and their formation and functioning, and (d) issues related to current implementation and future expansion of Title I to additional eligible metropolitan areas. Integral to the review is a brief discussion of the history of AIDS and HIV infection, particularly in cities receiving CARE Act funding, an overview of Title I requirements, and a description of the organizational structures cities are using to implement Title I. Information on Title I EMAs is based on analysis of their 1991 applications, bylaws of their HIV service planning councils, intergovernmental agreements between Title I cities and other political entities, and contracts executed by Title I grantees with providers for the delivery of services. Interviews with personnel in several Title I EMAs, including planning council members and grantee staff members, provided additional information. This is the first descriptive accounting of activities related to the 1991 applications for and uses of Title I funds, and the administrative and service issues related to this process. PMID:1410229
Olsson, Silas; Hofmann, Isa; Brambilla, Piero Maria; Jacobsson, Ulf; Kennedy, Paul; Roca, Josep; Schmitt, Karl-Jürgen; Wyke, Alexandra
2004-01-01
The aim with the round table was to give additional inputs and views to the specific technology oriented presentations focusing on issues dealing with the need, patients' view, the use and the business opportunities relating to wearable eHealth systems for personalised health management. Wearable eHealth systems for personalised health management are targeting citizens, patients at health risks and patients enrolled in open care or home care for monitoring, treatment or follow up. The developments so far show promises for these group categories, and in addition, could support developments in health care organisations and systems. However, the ethical issues and data privacy nature have to be seriously taken into account. The market is not yet developed, and this is the situation both in Europe and in the US. To be able to give the customers solid product information a standardised test bed for new equipment and services might speed up the market development. In the round table discussion it was highlighted that one has to differ between needs and demands. Needs are related to the prevalence of the diseases, the health risks, etc. Demands are more related to market developments and customers' willingness to pay for the new products and services. Further, technical interoperability was seen as a fundamental prerequisite for market acceptance. As wearable eHealth systems for personalised health management differ completely from traditional way of deliver healthcare, new reimbursement systems have to be developed and implemented.
Traumatic Brain Injury Rehabilitation in Hong Kong: A Review of Practice and Research.
Yu, Junhong; Tam, Helena M K; Lee, Tatia M C
2015-01-01
The rising public health concern regarding traumatic brain injury (TBI) implies a growing need for rehabilitation services for patients surviving TBI. To this end, this paper reviews the practices and research on TBI rehabilitation in Hong Kong so as to inform future developments in this area. This paper begins by introducing the general situation of TBI patients in Hong Kong and the need for rehabilitation. Next, the trauma system in Hong Kong is introduced. Following that is a detailed description of the rehabilitation services for TBI patients in Hong Kong, as exemplified by a rehabilitation hospital in Hong Kong. This paper will also review intervention studies on rehabilitating brain-injured populations in Hong Kong with respect to various rehabilitation goals. Lastly, the implications of culture-related issues will be discussed in relation to TBI. The intervention studies conducted in Hong Kong are generally successful in achieving various rehabilitative outcomes. Additionally, certain cultural-related issues, such as the stigma associated with TBI, may impede the rehabilitative process and lead to various psychosocial problems.
Personal assistance services in the workplace: A literature review.
Dowler, Denetta L; Solovieva, Tatiana I; Walls, Richard T
2011-10-01
Personal assistance services (PAS) can be valuable adjuncts to the complement of accommodations that support workers with disabilities. This literature review explored the professional literature on the use of PAS in the workplace. Bibliographic sources were used to locate relevant research studies on the use of PAS in the workplace. The studies in this review used both qualitative and quantitative methods to identify current definitions of work-related and personal care-related PAS, agency-directed versus consumer-directed PAS, long-term and short-term funding issues, development of PAS policy, and barriers to successful implementation of PAS. The studies uncovered issues related to (a) recruiting, training, and retaining personal assistants, (b) employer concerns, (c) costs and benefits of workplace PAS, (d) wages and incentives for personal assistants, and (e) sources for financing PAS as a workplace accommodation. The findings reveal the value and benefits of effective PAS on the job. PAS can lead to successful employment of people with disabilities when other accommodations cannot provide adequate workplace support. Additionally, the evolution of workplace PAS is dependent on development of realistic PAS policy and funding options. Published by Elsevier Inc.
Factors that introduce intrasubject variability into ear-canal absorbance measurements.
Voss, Susan E; Stenfelt, Stefan; Neely, Stephen T; Rosowski, John J
2013-07-01
Wideband immittance measures can be useful in analyzing acoustic sound flow through the ear and also have diagnostic potential for the identification of conductive hearing loss as well as causes of conductive hearing loss. To interpret individual measurements, the variability in test–retest data must be described and quantified. Contributors to variability in ear-canal absorbance–based measurements are described in this article. These include assumptions related to methodologies and issues related to the probe fit within the ear and potential acoustic leaks. Evidence suggests that variations in ear-canal cross-sectional area or measurement location are small relative to variability within a population. Data are shown to suggest that the determination of the Thévenin equivalent of the ER-10C probe introduces minimal variability and is independent of the foam ear tip itself. It is suggested that acoustic leaks in the coupling of the ear tip to the ear canal lead to substantial variations and that this issue needs further work in terms of potential criteria to identify an acoustic leak. In addition, test–retest data from the literature are reviewed.
Mitchison, Deborah; Mond, Jonathan
2015-01-01
Challenges to epidemiological studies of eating and related body image disturbance disorders in males include, in addition to low base rates and the predominance of residual diagnostic categories, the female-centric nature of current classification schemes and the consequent lack of appropriate assessment instruments. In this narrative review, we summarise epidemiological data regarding the prevalence and correlates of eating disorders, related body image disturbance disorders, and eating disorder features in males. Attention is focused on disorders most likely to be observed among males, such as muscle dysmorphia and muscularity-oriented excessive exercise. It is argued that, given the multiple challenges involved in research of this kind, a focus on features is more likely to advance the field than a focus on diagnoses. In terms of correlates, we focus on impairment and help-seeking, since these issues are most relevant in informing public health burden, service provision, and related issues. We end with some thoughts about current gaps in the knowledge base and directions for future research that we consider to be most promising.
Next-Generation WDM Network Design and Routing
NASA Astrophysics Data System (ADS)
Tsang, Danny H. K.; Bensaou, Brahim
2003-08-01
Call for Papers The Editors of JON are soliciting papers on WDM Network Design and Routing. The aim in this focus issue is to publish original research on topics including - but not limited to - the following: - WDM network architectures and protocols - GMPLS network architectures - Wavelength converter placement in WDM networks - Routing and wavelength assignment (RWA) in WDM networks - Protection and restoration strategies and algorithms in WDM networks - Traffic grooming in WDM networks - Dynamic routing strategies and algorithms - Optical Burst Switching - Support of Multicast - Protection and restoration in WDM networks - Performance analysis and optimization in WDM networks Manuscript Submission To submit to this special issue, follow the normal procedure for submission to JON, indicating "WDM Network Design" in the "Comments" field of the online submission form. For all other questions relating to this focus issue, please send an e-mail to jon@osa.org, subject line "WDM Network Design." Additional information can be found on the JON website: http://www.osa-jon.org/submission/. Schedule Paper Submission Deadline: November 1, 2003 Notification to Authors: January 15, 2004 Final Manuscripts to Publisher: February 15, 2004 Publication of Focus Issue: February/March 2004
Next-Generation WDM Network Design and Routing
NASA Astrophysics Data System (ADS)
Tsang, Danny H. K.; Bensaou, Brahim
2003-10-01
Call for Papers The Editors of JON are soliciting papers on WDM Network Design and Routing. The aim in this focus issue is to publish original research on topics including - but not limited to - the following: - WDM network architectures and protocols - GMPLS network architectures - Wavelength converter placement in WDM networks - Routing and wavelength assignment (RWA) in WDM networks - Protection and restoration strategies and algorithms in WDM networks - Traffic grooming in WDM networks - Dynamic routing strategies and algorithms - Optical burst switching - Support of multicast - Protection and restoration in WDM networks - Performance analysis and optimization in WDM networks Manuscript Submission To submit to this special issue, follow the normal procedure for submission to JON, indicating "WDM Network Design" in the "Comments" field of the online submission form. For all other questions relating to this focus issue, please send an e-mail to jon@osa.org, subject line "WDM Network Design." Additional information can be found on the JON website: http://www.osa-jon.org/submission/. Schedule - Paper Submission Deadline: November 1, 2003 - Notification to Authors: January 15, 2004 - Final Manuscripts to Publisher: February 15, 2004 - Publication of Focus Issue: February/March 2004
Next-Generation WDM Network Design and Routing
NASA Astrophysics Data System (ADS)
Tsang, Danny H. K.; Bensaou, Brahim
2003-09-01
Call for Papers The Editors of JON are soliciting papers on WDM Network Design and Routing. The aim in this focus issue is to publish original research on topics including - but not limited to - the following: - WDM network architectures and protocols - GMPLS network architectures - Wavelength converter placement in WDM networks - Routing and wavelength assignment (RWA) in WDM networks - Protection and restoration strategies and algorithms in WDM networks - Traffic grooming in WDM networks - Dynamic routing strategies and algorithms - Optical burst switching - Support of multicast - Protection and restoration in WDM networks - Performance analysis and optimization in WDM networks Manuscript Submission To submit to this special issue, follow the normal procedure for submission to JON, indicating "WDM Network Design" in the "Comments" field of the online submission form. For all other questions relating to this focus issue, please send an e-mail to jon@osa.org, subject line "WDM Network Design." Additional information can be found on the JON website: http://www.osa-jon.org/submission/. Schedule - Paper Submission Deadline: November 1, 2003 - Notification to Authors: January 15, 2004 - Final Manuscripts to Publisher: February 15, 2004 - Publication of Focus Issue: February/March 2004
Taylor, Valerie H; Hensel, Jennifer
2017-08-01
Multimorbidity is significant for obesity and mental health issues. As a consequence, mental illness is overrepresented in patients seeking bariatric surgery. This review addresses that overlap, with a focus on Canadian data. The healthcare system in Canada is unique, but issues related to prevalence of mental health in patients seeking bariatric surgery are similar to those in studies conducted in other countries. Although data on suicide are lacking, Canadian data have shown similar rates of self-harm behaviours and linkages between psychopathology and weight regain after surgery. Geographic issues that make it difficult for individuals to attend regular follow-up appointments have encouraged the use of e-health tools to engage patients and ensure access to follow-up care, which may provide unique opportunities going forward. Additional work is needed to inform best practices in the Canadian system, but in keeping with other data, the consistent message from Canada is that appropriate evaluation and aftercare are essential components of a well-informed bariatric program. Copyright © 2017 Diabetes Canada. Published by Elsevier Inc. All rights reserved.
Ethical issues in microbicide clinical trials for HIV prevention.
Gangestad, Angelina K; Salata, Robert A
2012-01-01
Women account for half of new infections with HIV annually. Heterosexual transmission is the most common route of infection in resource limited settings (RLS). An effective microbicide would help decrease transmission of HIV and potentially enable women to have more control in sexual relationships. Research into microbicides is done predominantly in RLS. In addition, there will be different issues and challenges to consider with respect to rectal microbicide use in men. There exist several ethical issues around microbicide development and clinical research which we explore in this review. Respect for persons, including autonomy and protection of vulnerable populations, beneficence, and justice are explored as they relate to microbicide research. Improving standards of care in RLS, trial design, and informed consent are discussed in more detail. Special populations including pregnant women, adolescents, and men who have sex with men are considered in more detail. A multipronged approach to HIV prevention will be necessary to have an impact on HIV prevention. A continued discussion around ethical issues in regard to study design, interpretation of results and implementation of compounds brought to market will remain critically important.
Is the biggest security threat to medical information simply a lack of understanding?
Williams, Patricia A H
2011-01-01
Connecting Australian health services and the e-health initiative is a major focus in the current health environment. Many issues are presented as key to its success including solving issues with confidentiality and privacy. However, the main problem may not be these issues in sharing information but the fact that the point of origin of such records is still relatively insecure. This paper highlights why this may be the case. Research into the security of medical information has shown that many primary healthcare providers are unable to create an environment with effective information security. Numerous factors contribute to this complex situation including a trustful environment, the resultant security culture and the capability of individual healthcare organisations. Further, the growing importance of new directions in the use of patient information is considered. This paper discusses these issues and positions them within the complex environment that is healthcare. In our current health system infrastructure, the points of origin of patient information are our most vulnerable. This entwined with progressively new uses of this information expose additional security concerns, such as re-identification of information, that require attention.
Overview of transboundary pollution issues along the Mexico-US border
DOE Office of Scientific and Technical Information (OSTI.GOV)
Medina, E.J.
1996-12-31
This paper presents an overview of pollution issues affecting the Mexico-US border region, and briefly traces the development of the international legal framework which covers Mexico-US border relations on environmental issues. Examples from different border areas are used to illustrate surface water, groundwater, air pollution, and hazardous waste problems associated with the rapid growth and industrialization of areas along the border. Some of the specific issues presented include the Tijuana-San Diego sewage problem, the New River toxic discharges, Nogales Wash groundwater pollution, air pollution in Cd. Juarez-El Paso, and the Alco-Pacifico lead contamination case in Tijuana, B.C. Additional research tomore » characterize the extent of border area pollution and resultant ecological impacts is fundamental in the development of binational policies to deal with these problems. Another priority need is the application of risk assessment models, which will help policy makers on both sides of the border to coordinate efforts and allocate resources to solve this crisis. Immediate attention should be directed toward acquiring information necessary to evaluate the impacts of border-area pollution on natural ecosystems.« less
Life Cycle Assessment and Carbon Footprint in the Wine Supply-Chain
NASA Astrophysics Data System (ADS)
Pattara, Claudio; Raggi, Andrea; Cichelli, Angelo
2012-06-01
Global warming represents one of the most critical internationally perceived environmental issues. The growing, and increasingly global, wine sector is one of the industries which is under increasing pressure to adopt approaches for environmental assessment and reporting of product-related greenhouse gas emissions. The International Organization for Vine and Wine has recently recognized the need to develop a standard and objective methodology and a related tool for calculating carbon footprint (CF). This study applied this tool to a wine previously analyzed using the life cycle assessment (LCA) methodology. The objective was to test the tool as regards both its potential and possible limitations, and thus to assess its suitability as a standard tool. Despite the tool's user-friendliness, a number of limitations were noted including the lack of accurate baseline data, a partial system boundary and the impossibility of dealing with the multi-functionality issue. When the CF and LCA results are compared in absolute terms, large discrepancies become obvious due to a number of different assumptions, as well as the modeling framework adopted. Nonetheless, in relative terms the results seem to be quite consistent. However, a critical limitation of the CF methodology was its focus on a single issue, which can lead to burden shifting. In conclusion, the study confirmed the need for both further improvement and adaptation to additional contexts and further studies to validate the use of this tool in different companies.
Life cycle assessment and carbon footprint in the wine supply-chain.
Pattara, Claudio; Raggi, Andrea; Cichelli, Angelo
2012-06-01
Global warming represents one of the most critical internationally perceived environmental issues. The growing, and increasingly global, wine sector is one of the industries which is under increasing pressure to adopt approaches for environmental assessment and reporting of product-related greenhouse gas emissions. The International Organization for Vine and Wine has recently recognized the need to develop a standard and objective methodology and a related tool for calculating carbon footprint (CF). This study applied this tool to a wine previously analyzed using the life cycle assessment (LCA) methodology. The objective was to test the tool as regards both its potential and possible limitations, and thus to assess its suitability as a standard tool. Despite the tool's user-friendliness, a number of limitations were noted including the lack of accurate baseline data, a partial system boundary and the impossibility of dealing with the multi-functionality issue. When the CF and LCA results are compared in absolute terms, large discrepancies become obvious due to a number of different assumptions, as well as the modeling framework adopted. Nonetheless, in relative terms the results seem to be quite consistent. However, a critical limitation of the CF methodology was its focus on a single issue, which can lead to burden shifting. In conclusion, the study confirmed the need for both further improvement and adaptation to additional contexts and further studies to validate the use of this tool in different companies.
Demner-Fushman, D; Elhadad, N
2016-11-10
This paper reviews work over the past two years in Natural Language Processing (NLP) applied to clinical and consumer-generated texts. We included any application or methodological publication that leverages text to facilitate healthcare and address the health-related needs of consumers and populations. Many important developments in clinical text processing, both foundational and task-oriented, were addressed in community- wide evaluations and discussed in corresponding special issues that are referenced in this review. These focused issues and in-depth reviews of several other active research areas, such as pharmacovigilance and summarization, allowed us to discuss in greater depth disease modeling and predictive analytics using clinical texts, and text analysis in social media for healthcare quality assessment, trends towards online interventions based on rapid analysis of health-related posts, and consumer health question answering, among other issues. Our analysis shows that although clinical NLP continues to advance towards practical applications and more NLP methods are used in large-scale live health information applications, more needs to be done to make NLP use in clinical applications a routine widespread reality. Progress in clinical NLP is mirrored by developments in social media text analysis: the research is moving from capturing trends to addressing individual health-related posts, thus showing potential to become a tool for precision medicine and a valuable addition to the standard healthcare quality evaluation tools.
Investigation of display issues relevant to the presentation of aircraft fault information
NASA Technical Reports Server (NTRS)
Allen, Donald M.
1989-01-01
This research, performed as a part of NASA Langley's Faultfinder project, investigated display implementation issues related to the introduction of real time fault diagnostic systems into next generation commercial aircraft. Three major issues were investigated: visual display styles for presenting fault related information to the crew, the form the output from the expert system should take, and methods for filtering fault related information for presentation to the crew. Twenty-four flight familiar male volunteers participated as subjects. Five subjects were NASA test pilots, six were Commercial Airline Pilots, seven were Air Force Lear Jet pilots, and six were NASA personnel familiar with flight (non-pilots). Subjects were presented with aircraft subsystem information on a CRT screen. They were required to identify the subsystems presented in a display and to remember the state (normal or abnormal) of subsystem parameter information contained in the display. The results of the study indicated that in the simpler experimental test cases (i.e., those involving single subsystem failures and composite hypothesis displays) subjects' performance did not differ across the different display formats. However, for the more complex cases (i.e., those involving multiple subsystem faults and multiple hypotheses displays), subjects' performance was superior in the text- and picture-based display formats compared to the symbol-based format. In addition, the findings suggest that a layered approached to information display is appropriate.
Code of Federal Regulations, 2012 CFR
2012-01-01
... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...
Code of Federal Regulations, 2013 CFR
2013-07-01
... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...
Code of Federal Regulations, 2014 CFR
2014-01-01
... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...
Code of Federal Regulations, 2011 CFR
2011-01-01
... OF SPACE Location of Space Delineated Area § 102-83.30 In addition to its mission and program... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false In addition to its mission and program requirements, are there any other issues that Federal agencies must consider in...
ERIC Educational Resources Information Center
Lipton, Morris; Wender, Esther
The National Advisory Committee on Hyperkinesis and Food Additives paper summarized some research findings on the issue of the relationship between food-additive-free diets and hyperkinesis in children. Based on several challenge studies, it is concluded that the evidence generally refutes Dr. B. F. Feingold's claim that artificial colorings in…
Race, region and risk: An examination of minority proximity to noxious facilities
DOE Office of Scientific and Technical Information (OSTI.GOV)
Nieves, A.L.; Nieves, L.A.
1996-04-01
The past decade has given rise to terms like environmental racism, eco-racism, and environmental inequities to characterize a disproportional distribution of environmental disamenities among minority communities. Much of the literature supports the contention that racial and ethnic minorities and low-income groups bear a disproportionate burden of risk from hazardous activities and substances in the environment. This study expands the scope of prior studies by employing county-level data for the entire nation and including a broad range of facility types associated with environmental disamenities. In addition, it addresses the issue of the distribution of noxious facilities among white and non-white populationsmore » in an attempt to determine the relative exposure to risk among different racial and ethnic groups. In addition, the authors also explore the relative importance of nonurban versus urban residence.« less
Issues in healthcare services in Malaysia as experienced by Japanese retirees.
Kohno, Ayako; Musa, Ghazali; Nik Farid, Nik Daliana; Abdul Aziz, Norlaili; Nakayama, Takeo; Dahlui, Maznah
2016-05-05
Worldwide, international retirement migration is growing in its popularity and Japanese retirees choose Malaysia as their most preferred destination. This study examines the pertinent issues related to healthcare services as experienced by Japanese retirees in this country. From January to March 2015, we conducted focus group discussions with 30 Japanese retirees who live in Kuala Lumpur and Ipoh. Guided by the social-ecological model, we discovered seven pertinent themes: 'language barriers','healthcare decisions', 'medical check-ups','healthcare insurance', 'nursing and palliative care', 'trust and distrust of healthcare services', and 'word-of-mouth information'. We identified seven pertinent issues related to healthcare services among Japanese retirees in Malaysia, of which four are especially important. These issues are explained as integrated themes within the social-ecological model. Language barriers prohibit them from having difficulty accessing to healthcare in Malaysia, but lack of will to improve their language skills exist among them. For that reason, they rely heavily on word-of-mouth information when seeking for healthcare. As a consequence, some develop feelings of trust and distrust of healthcare services. In addition, we have identified the needs for provide nursing and palliative care among Japanese retirees in Malaysia. Based on the magnitude of the discussion, we concluded that there are four crucial healthcare issues among Japanese retirees; 'language barriers', 'trust and distrust of healthcare services', 'word-of-mouth information' and 'nursing and palliative care'. We propose that further dialogue by healthcare stakeholders should be carried out to improve further the healthcare service provisions for Japanese retirees in Malaysia.
The interdisciplinary nature of SOIL
NASA Astrophysics Data System (ADS)
Brevik, E. C.; Cerdà, A.; Mataix-Solera, J.; Pereg, L.; Quinton, J. N.; Six, J.; Van Oost, K.
2015-01-01
The holistic study of soils requires an interdisciplinary approach involving biologists, chemists, geologists, and physicists, amongst others, something that has been true from the earliest days of the field. In more recent years this list has grown to include anthropologists, economists, engineers, medical professionals, military professionals, sociologists, and even artists. This approach has been strengthened and reinforced as current research continues to use experts trained in both soil science and related fields and by the wide array of issues impacting the world that require an in-depth understanding of soils. Of fundamental importance amongst these issues are biodiversity, biofuels/energy security, climate change, ecosystem services, food security, human health, land degradation, and water security, each representing a critical challenge for research. In order to establish a benchmark for the type of research that we seek to publish in each issue of SOIL, we have outlined the interdisciplinary nature of soil science research we are looking for. This includes a focus on the myriad ways soil science can be used to expand investigation into a more holistic and therefore richer approach to soil research. In addition, a selection of invited review papers are published in this first issue of SOIL that address the study of soils and the ways in which soil investigations are essential to other related fields. We hope that both this editorial and the papers in the first issue will serve as examples of the kinds of topics we would like to see published in SOIL and will stimulate excitement among our readers and authors to participate in this new venture.
International and cross-cultural issues: six key challenges for our professions.
Marshall, Julie
2003-01-01
This paper discusses a number of key challenges facing professionals who work with people who have communication disabilities. The challenges are related to working internationally and in a cross-culturally competent way. Each challenge is discussed, drawing on material from a range of sources, including the papers in the final 2003 edition of FOLIA PHONIATRICA ET LOGOPAEDICA ('International and Cross-Cultural Issues'). The challenges discussed cover how experiences from majority world countries can be used to benefit services elsewhere, 'mainstreaming' commitment to cross-cultural competence, learning from relationships with other professionals, influencing research practice, responding to requests to work internationally and finally, dealing with cultural differences that challenge working practices. Some solutions are suggested and additional questions posed. Copyright 2003 S. Karger AG, Basel
Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-24
...This action promulgates amendments to the National Emission Standards for Hazardous Air Pollutants for Source Categories: Gasoline Distribution Bulk Terminals, Bulk Plants, and Pipeline Facilities; and Gasoline Dispensing Facilities, which EPA promulgated on January 10, 2008, and amended on March 7, 2008. In this action, EPA is finalizing amendments and clarifications to certain definitions and applicability provisions of the final rules in response to some of the issues raised in the petitions for reconsideration. In addition, several other compliance-related questions posed by various individual stakeholders and State and local agency representatives are addressed in this action. We are also denying reconsideration on one issue raised in a petition for reconsideration received by the Agency on the final rules.
Testing local anisotropy using the method of smoothed residuals I — methodology
DOE Office of Scientific and Technical Information (OSTI.GOV)
Appleby, Stephen; Shafieloo, Arman, E-mail: stephen.appleby@apctp.org, E-mail: arman@apctp.org
2014-03-01
We discuss some details regarding the method of smoothed residuals, which has recently been used to search for anisotropic signals in low-redshift distance measurements (Supernovae). In this short note we focus on some details regarding the implementation of the method, particularly the issue of effectively detecting signals in data that are inhomogeneously distributed on the sky. Using simulated data, we argue that the original method proposed in Colin et al. [1] will not detect spurious signals due to incomplete sky coverage, and that introducing additional Gaussian weighting to the statistic as in [2] can hinder its ability to detect amore » signal. Issues related to the width of the Gaussian smoothing are also discussed.« less
Real-time landslide warning during heavy rainfall
Keefer, D.K.; Wilson, R.C.; Mark, R.K.; Brabb, E.E.; Brown, W. M.; Ellen, S.D.; Harp, E.L.; Wieczorek, G.F.; Alger, C.S.; Zatkin, R.S.
1987-01-01
A real-time system for issuing warnings of landslides during major storms is being developed for the San Francisco Bay region, California. The system is based on empirical and theoretical relations between rainfall and landslide initiation, geologic determination of areas susceptible to landslides, real-time monitoring of a regional network of telemetering rain gages, and National Weather Service precipitation forecasts. This system was used to issue warnings during the storms of 12 to 21 February 1986, which produced 800 millimeters of rainfall in the region. Although analysis after the storms suggests that modifications and additional developments are needed, the system successfully predicted the times of major landslide events. It could be used as a prototype for systems in other landslide-prone regions.
Khanna, Dinesh; Hays, Ron D; Furst, Daniel E
2017-09-01
Patients with SSc have the highest mortality among the rheumatic diseases. In addition, SSc is associated with disfigurement, hand contractures, fatigue, poor sleep, severe RP with numbness and tingling of the fingers can lead to decrements in quality of life. This Points to Consider article provides practical considerations for design of trials for functional disability and other health-related quality-of-life issues. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Glossary on the environmental impact of a nuclear war. Technical note
DOE Office of Scientific and Technical Information (OSTI.GOV)
Verstraete, M.M.
1986-02-01
The glossary defines a number of words, expressions, and acronyms used in the description of the impact of nuclear war on the environment, and associated issues. Selected additional words related to the problems of armaments, disarmament, and nuclear war in general were also added for convenience, although terms and expressions specifically related to the medical aspects of the problem were not included. The glossary is an enlarged and updated version of the glossary that was published as part of the SCOPE-Enuwar study on the same subject, and published by Wiley (Pittock et al., 1986).
[The primary medical sanitary care and characteristics of drinking water supply of population].
Nechaev, V S; Saurina, O S
2016-01-01
The article considers characteristics of organization ofprimary medical sanitary care on territory with carcinogenic risks related to drinking water supply as exemplified by the Orlovskaia oblast. The importance of registration by local health authorities the sources of permanent chemical pollution of drinking water. The analysis of the State program of the Orlovskaia oblast “The development of health care in the Orlovskaia oblast in 2013-2020". The necessity of additional inclusion of issue related to healthy drinking water supply of population to prevent development of malignant neoplasms and prevalence of oncologic morbidity on oblast territory.
On Convergence Acceleration Techniques for Unstructured Meshes
NASA Technical Reports Server (NTRS)
Mavriplis, Dimitri J.
1998-01-01
A discussion of convergence acceleration techniques as they relate to computational fluid dynamics problems on unstructured meshes is given. Rather than providing a detailed description of particular methods, the various different building blocks of current solution techniques are discussed and examples of solution strategies using one or several of these ideas are given. Issues relating to unstructured grid CFD problems are given additional consideration, including suitability of algorithms to current hardware trends, memory and cpu tradeoffs, treatment of non-linearities, and the development of efficient strategies for handling anisotropy-induced stiffness. The outlook for future potential improvements is also discussed.
Creating environments that foster academic integrity.
Tippitt, Michelle Pixley; Ard, Nell; Kline, Juanita Reese; Tilghman, Joan; Chamberlain, Barbara; Meagher, P Gail
2009-01-01
A number of studies related to academic dishonesty within the nursing student population have been published; however, little has been written in the nursing literature regarding academic integrity and means of promoting this value. In addition to the many short-term solutions to prevent cheating and dissuade academic misconduct that are offered, solutions that promote long-term affective changes underlying the acquisition of academic integrity are needed. This article provides a context for discussions related to academic integrity, explores issues facing faculty when dealing with this challenge, and offers short-term and long-term strategies for creating environments that foster academic integrity.
Education and Training Issues Related to Major Disasters
2005-11-04
Mississippi that were affected by Hurricane Katrine would be permitted to reduce their academic year from 30 weeks of instructional time to 26 weeks... hurricanes . In addition, it is estimated that approximately 30 institutions of higher education (IHEs) in the affected areas have been severely damaged...of Hurricanes Katrina and Rita on employment probably resulted in the loss of between 293,000 and 480,000 jobs. Many of these individuals will not
Measure Guideline. Air Sealing Attics in Multifamily Buildings
DOE Office of Scientific and Technical Information (OSTI.GOV)
Otis, Casey; Maxwell, Sean
2012-06-01
This Building America Measure Guideline is intended for owners, builders, contractors, homeowners, and other stakeholders in the multifamily building industry, and focuses on challenges found in existing buildings for a variety of housing types. It explains why air sealing is desirable, explores related health and safety issues, and identifies common air leakage points in multifamily building attics. In addition, it also gives an overview of materials and techniques typically used to perform air sealing work.
Measure Guideline: Air Sealing Attics in Multifamily Buildings
DOE Office of Scientific and Technical Information (OSTI.GOV)
Otis, C.; Maxwell, S.
2012-06-01
This Building America Measure Guideline is intended for owners, builders, contractors, homeowners, and other stakeholders in the multifamily building industry, and focuses on challenges found in existing buildings for a variety of housing types. It explains why air sealing is desirable, explores related health and safety issues, and identifies common air leakage points in multifamily building attics. In addition, it also gives an overview of materials and techniques typically used to perform air sealing work.
Space Shuttle Five-Segment Booster (Short Course)
NASA Technical Reports Server (NTRS)
Graves, Stanley R.; Rudolphi, Michael (Technical Monitor)
2002-01-01
NASA is considering upgrading the Space Shuttle by adding a fifth segment (FSB) to the current four-segment solid rocket booster. Course materials cover design and engineering issues related to the Reusable Solid Rocket Motor (RSRM) raised by the addition of a fifth segment to the rocket booster. Topics cover include: four segment vs. five segment booster, abort modes, FSB grain design, erosive burning, enhanced propellant burn rate, FSB erosive burning model development and hardware configuration.
2015-09-01
be strengthened in both areas. • DOD has a decentralized structure to administer and oversee its existing, required compliance -based ethics program...and attributes. “Ethics” relates to DOD’s required rules-based program, which ensures compliance with standards of conduct. 2 The White House...ethical content in professional military education , developing 13 character development initiatives for general and flag officers, and establishing
Venezuela: Issues in the 111th Congress
2010-09-03
in January 2010 under the de facto government of Roberto Micheletti. In June 2009, three additional countries joined— Ecuador , St. Vincent and the...files from Colombia’s March 2008 raid of a FARC camp in Ecuador had raised questions about potential support of the FARC by the Chávez government ...has been friction in relations for almost a decade under the government of populist President Hugo Chávez. U.S. officials have expressed concerns
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kelly, J.R.; Duke, T.W.; Harwell, M.A.
Potential effects of oil drilling-fluid discharges upon Thalassia seagrass ecosystems were examined to provide general insights and raise ecotoxicological issues relevant to problems of addressing a priori, ecolgical effects of anthropogenic actions. Microcosm experiments have demonstrated effects upon both autotrophic and heterotrophic species, as well as the processes of primary productivity and decomposition. Significant ecological changes may result from disturbance effects related to the physical presence of higher particle loads, in addition to effects resulting from toxic features of drilling fluids.
Willen, Sarah S
2012-03-01
Do unauthorized im/migrants have a right to health? Do they deserve health care, or health protection, or access to the social determinants of good health? Are they party to prevailing social contracts, or does their exclusion from mainstream systems of health promotion, prevention, and care "make sense"? Questions like these, which generate considerable attention in multiple spheres of scholarship, policy, and public debate, revolve around an issue that merits substantially greater consideration among social scientists of health: health-related "deservingness." In addition to putting the issue of health-related deservingness squarely on the map as an object of analysis, this article further argues that we cannot focus solely on those with power, influence, and public voice. Rather, we also must investigate how deservingness is reckoned in relation to--and, furthermore, from the perspectives of-- unauthorized im/migrants and members of other groups commonly constructed in public and policy discourse as undeserving. Additionally, we must consider the complicated relationship between universalizing juridical arguments about formal entitlement to health rights, on one hand, and situationally specific, vernacular moral arguments about deservingness, on the other. The paper analyzes findings from a 29-month mixed-methods study conducted in Tel Aviv, Israel, that approached unauthorized im/migrants as subjects, rather than simply objects, of ethical deliberation. Participants' conceptions of health-related deservingness are investigated using two sources of data: (1) quantitative findings from a self-administered, closed-ended survey conducted with 170 im/migrant patients at an NGO-run Open Clinic (2002-2003), and (2) qualitative findings from the larger ethnographic study of which the survey was part (2000-2010). The study findings both (1) contradict commonly circulating assumptions that unauthorized im/migrants are "freeloaders," and (2) highlight the need for rigorous investigation of how unauthorized im/migrants, among other marginalized and vulnerable groups, conceptualize their own relative deservingness of health-related concern and investment. Copyright © 2011 Elsevier Ltd. All rights reserved.
Is content of medical journals related to advertisements? Case-control study.
Vlassov, Vasiliy V
2007-12-01
To assess the relatedness of journal content to paid advertisements published in the journal. The case-control study was performed on a convenience sample of 7 journals subscribed by Central Medical Library in Moscow--4 international (American Journal of Hypertension, British Journal of General Practice, The Lancet, and New England Journal of Medicine) and 3 Russian peer reviewed journals (Terapevticheskii Arkhiv, Khirurgiia, and Voeno-Meditsinskii Zhurnal). In each issue containing a paid advertisement, classifieds excluded, we searched for articles related to the advertised product and compared this issue with a control issue - the next or a later issue without this advertisement. In American Journal of Hypertension (33 issues from 2002-2004) 94 placements of advertisements were found, 7 of which were closely related to the article topic in the same issue (7/94) vs 2/66 in the control issue. The odds ratio (OR) and 95% confidence interval (CI) for advertisements to be accompanied by related articles was OR, 2.6; 95%CI, 0.5-13). In British Journal of General Practice (27 issues from 2003-2005) there were 7/63 advertisements related to the article topic vs 0/28 in the control issue (OR, 7.2; 95% CI, 1.3 to 44). In The Lancet (49 issues from 2004) there were 8/162 advertisements related to the article topic vs 8/104 in the control issue (OR, 0.6; 95% CI, 0.3-1.5). In New England Journal of Medicine (37 issues from 2004) there were 12/81 advertisements related to the article topic vs 8/75 in the control issue (OR, 1.5; 95% CI, 0.56-3.79). In Terapevticheskii Arkhiv (10 issues from 2004) there were 38/93 advertisements related to the article topic vs 1/83 in the control issue (OR, 56.66; 95% CI, 4.4-253). In Khirurgiia (25 issues from 2003-2005) there were 3/83 advertisements related to the article topic vs 0/70 in the control issue (OR, 2.7; 95% CI, 0.3-26). In Voeno-Meditsinskii Zhurnal (33 issues from 2003-2005) there were 17/31 advertisements related to the article topic vs 2/31 in the control issue (OR,17.6; 95% CI, 3.6-87). The strong relatedness between the content of the articles and advertisements placed in 3 of 7 journals and explicit placement of the advertisements face to face or overleaf the related research articles support the hypothesis that journal content is manipulated to place more emphasis on the advertisements.
Is Content of Medical Journals Related to Advertisements? Case-control Study
Vlassov, Vasiliy V.
2007-01-01
Aim To assess the relatedness of journal content to paid advertisements published in the journal. Methods The case-control study was performed on a convenience sample of 7 journals subscribed by Central Medical Library in Moscow – 4 international (American Journal of Hypertension, British Journal of General Practice, The Lancet, and New England Journal of Medicine) and 3 Russian peer reviewed journals (Terapevticheskii Arkhiv, Khirurgiia, and Voeno-Meditsinskii Zhurnal). In each issue containing a paid advertisement, classifieds excluded, we searched for articles related to the advertised product and compared this issue with a control issue – the next or a later issue without this advertisement. Results In American Journal of Hypertension (33 issues from 2002-2004) 94 placements of advertisements were found, 7 of which were closely related to the article topic in the same issue (7/94) vs 2/66 in the control issue. The odds ratio (OR) and 95% confidence interval (CI) for advertisements to be accompanied by related articles was OR, 2.6; 95%CI, 0.5-13). In British Journal of General Practice (27 issues from 2003-2005) there were 7/63 advertisements related to the article topic vs 0/28 in the control issue (OR, 7.2; 95% CI, 1.3 to 44). In The Lancet (49 issues from 2004) there were 8/162 advertisements related to the article topic vs 8/104 in the control issue (OR, 0.6; 95% CI, 0.3-1.5). In New England Journal of Medicine (37 issues from 2004) there were 12/81 advertisements related to the article topic vs 8/75 in the control issue (OR, 1.5; 95% CI, 0.56-3.79). In Terapevticheskii Arkhiv (10 issues from 2004) there were 38/93 advertisements related to the article topic vs 1/83 in the control issue (OR, 56.66; 95% CI, 4.4-253). In Khirurgiia (25 issues from 2003-2005) there were 3/83 advertisements related to the article topic vs 0/70 in the control issue (OR, 2.7; 95% CI, 0.3-26). In Voeno-Meditsinskii Zhurnal (33 issues from 2003-2005) there were 17/31 advertisements related to the article topic vs 2/31 in the control issue (OR,17.6; 95% CI, 3.6-87). Conclusions The strong relatedness between the content of the articles and advertisements placed in 3 of 7 journals and explicit placement of the advertisements face to face or overleaf the related research articles support the hypothesis that journal content is manipulated to place more emphasis on the advertisements. PMID:18074412
16 CFR 456.5 - Rules applicable to prescriptions for contact lenses and related issues.
Code of Federal Regulations, 2010 CFR
2010-01-01
... contact lenses and related issues. 456.5 Section 456.5 Commercial Practices FEDERAL TRADE COMMISSION TRADE... contact lenses and related issues. Rules applicable to prescriptions for contact lenses and related issues may be found at 16 CFR part 315 (Contact Lens Rule). [69 FR 40511, July 2, 2004] ...
Reed, David L.; Currier, Russell W.; Walton, Shelley F.; Conrad, Melissa; Sullivan, Steven A.; Carlton, Jane M.; Read, Timothy D.; Severini, Alberto; Tyler, Shaun; Eberle, R.; Johnson, Welkin E.; Silvestri, Guido; Clarke, Ian N.; Lagergård, Teresa; Lukehart, Sheila A.; Unemo, Magnus; Shafer, William M.; Beasley, R. Palmer; Bergström, Tomas; Norberg, Peter; Davison, Andrew J.; Sharp, Paul M.; Hahn, Beatrice H.; Blomberg, Jonas
2013-01-01
The following series of concise summaries addresses the evolution of infectious agents in relation to sex in animals and humans from the perspective of three specific questions: (1) what have we learned about the likely origin and phylogeny, up to the establishment of the infectious agent in the genital econiche, including the relative frequency of its sexual transmission; (2) what further research is needed to provide additional knowledge on some of these evolutionary aspects; and (3) what evolutionary considerations might aid in providing novel approaches to the more practical clinical and public health issues facing us currently and in the future? PMID:21824167
Green, J Marshall; Sabino, Jennifer; Fleming, Mark; Valerio, Ian
2015-03-01
In the recent Iraq and Afghanistan conflicts, survival rates from complex battlefield injuries have continued to improve. The resulting war-related wounds are challenging, with confounding issues making assessment of tissue perfusion subjective and variable. This review discusses the utility of intraoperative fluorescence angiography, and its usefulness as an objective tool to evaluate the perfusion of tissues in the face of complex war-related injuries. A retrospective review of all war-related traumatic and reconstructive cases employing intraoperative indocyanine green laser angiography (ICGLA) was performed. Data analyzed included indication for use, procedure success/failure rates, modifications performed, and perfusion-related complications. Anatomical regions assessed were extremity, head and neck, truncal, and intra-abdominal viscera. The endpoint of specific interest involved the decision for additional debridement of poorly perfused tissue, as based on the ICGLA findings. Over a 3-year period, this study examined 123 extremity soft tissue flaps, 41 extremity injuries including amputation and/or amputation revision cases, 13 craniofacial flaps, and 9 truncal/abdomen/gastrointestinal cases in which ICGLA was utilized to assess tissue perfusion and viability. A total of 35 (18.8%) of cases employing ICGLA required intraoperative modifications to address perfusion-related issues. Intraoperative fluorescent angiography is an objective, useful tool to assess various war-related traumatic injuries. This study expands on prior cited indications for ICGLA to include (1) guiding debridement in heavily contaminated wounds, (2) providing improved assessment of avulsion soft tissue injuries, (3) allowing for rapid detection of vascular and/or microvascular compromise in soft tissue and osseous flap reconstructions, (4) reducing and preventing perfusion-related complications in trauma, amputation closures, and reconstruction procedures, (5) contributing to better outcomes in certain complex orthopedic and composite tissue injuries, and (6) enabling improved postoperative wound and reconstruction assessment in those cases of perfusion-related issues that arise within a delayed setting. Reprint & Copyright © 2015 Association of Military Surgeons of the U.S.
Bradshaw, Catherine P.; Waasdorp, Tracy E.; O'Brennan, Lindsey M.; Gulemetova, Michaela
2014-01-01
Given growing concerns regarding the prevalence and seriousness of bullying, the National Education Association recently drew upon its membership to launch a national study of teachers’ and education support professionals’ perceptions of bullying, and need for additional training on bullying prevention efforts and school-wide policies. The data were collected from a representative sample of 5,064 National Education Association members (2,163 teachers and 2,901 education support professionals). Analyses indicated that compared to education support professionals, teachers were more likely to witness students being bullied, more likely to view bullying as a significant problem at their school, and were more likely to have students report bullying to them. Teachers were more likely to be involved in bullying policies at their school, yet both groups reported wanting more training related to cyberbullying and bullying related to students’ sexual orientation, gender issues, and racial issues. Implications for school psychologists and the development of school-wide bullying prevention efforts are discussed. PMID:25414539
NASA Astrophysics Data System (ADS)
Adrian, Brian; Zollman, Dean; Stevens, Scott
2006-02-01
To demonstrate how state-of-the-art video databases can address issues related to the lack of preparation of many physics teachers, we have created the prototype Physics Teaching Web Advisory (Pathway). Pathway's Synthetic Interviews and related video materials are beginning to provide pre-service and out-of-field in-service teachers with much-needed professional development and well-prepared teachers with new perspectives on teaching physics. The prototype was limited to a demonstration of the systems. Now, with an additional grant we will extend the system and conduct research and evaluation on its effectiveness. This project will provide virtual expert help on issues of pedagogy and content. In particular, the system will convey, by example and explanation, contemporary ideas about the teaching of physics and applications of physics education research. The research effort will focus on the value of contemporary technology to address the continuing education of teachers who are teaching in a field in which they have not been trained.
A Four-Component Model of Sexual Orientation & Its Application to Psychotherapy.
Bowins, Brad
Distress related to sexual orientation is a common focus in psychotherapy. In some instances the distress is external in nature as with persecution, and in others it is internal as with self-acceptance issues. Complicating matters, sexual orientation is a very complex topic producing a great deal of confusion for both clients and therapists. The current paper provides a four component model-sexual orientation dimensions, activation of these dimensions, the role of erotic fantasy, and social construction of sexual orientation-that in combination provide a comprehensive perspective. Activation of dimensions is a novel contribution not proposed in any other model. With improved understanding of sexual orientation issues, and utilization of this knowledge to guide interventions, psychotherapists can improve outcomes with their clients. Also described is how dimensions of sexual orientation relate to transgender. In addition to improving psychotherapy outcomes, the fourcomponent model presented can help reduce discrimination and persecution, by demonstrating that the capacity for both homoerotic and heteroerotic behavior is universal.
The status of blood banking in India.
Gupta, A
2000-01-01
This article addresses some of the issues related to blood transfusion services in India. In terms of the need for blood transfusion, it is noted that, in the country, the death toll for road accidents has increased due to the unavailability of blood transfusion services near the accident sites. Considering the importance of blood, guidelines have been prescribed for the institutions responsible for collecting, storing, labeling and supplying blood. In addition, rigid requirements in relation to the infrastructure as well as qualified medical staff who have to operate the blood tank have been specified. According to a report in 1990, the blood banking system in the country have many shortcomings, including lack of infrastructure; decentralized nature and lack of adequate human, technological and financial resources. In view of this, the National Policy framework on blood transfusion services recommended several strategies to achieve the goal of improving such services in the country. Moreover, initiatives addressing the issue of shortfall in the annual requirement of blood are cited.
Individual pay-for-performance in Canadian healthcare organizations.
Greengarten, Moshe; Hundert, Mark
2006-01-01
Pink et al. discuss some of the issues related to pay-for-performance for individual and organizational healthcare providers. This commentary addresses key success factors for the implementation of individual pay-for-performance in publicly financed Canadian healthcare organizations. Publicly financed healthcare organizations in Canada have been relatively slow to adopt performance-pay programs as compared with private sector organizations; and those that have been developed have been, for the most part, rather crude. In many cases, they have become an additional mechanism for delivering base pay, rather than a true variable-pay program that motivates and differentiates performance. In light of the many issues that need to be addressed, we feel that pay-for-performance should be introduced gradually, beginning at the most senior levels of the organization. Above all, it is critical for publicly financed healthcare organizations to recognize that introducing pay-for-performance involves not only a set of structures and processes, but also likely a profound change in organizational values and behaviours.
49 CFR 172.203 - Additional description requirements.
Code of Federal Regulations, 2011 CFR
2011-10-01
..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...
49 CFR 172.203 - Additional description requirements.
Code of Federal Regulations, 2012 CFR
2012-10-01
..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...
49 CFR 172.203 - Additional description requirements.
Code of Federal Regulations, 2014 CFR
2014-10-01
..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...
49 CFR 172.203 - Additional description requirements.
Code of Federal Regulations, 2013 CFR
2013-10-01
..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.203 Additional description requirements. (a) Special permits. Except as provided in § 173.23 of this subchapter, each shipping paper issued in... to which the special permit applies. Each shipping paper issued in connection with a shipment made...
Noto, Ana Regina; Pinsky, Ilana; Mastroianni, Fábio de Carvalho
2006-01-01
Print media is one of the key factors for defining public opinion and setting public policies regarding drugs. Therefore, surveying its content should provide us with a better understanding of the situation. The few existing surveys on this issue in Brazil point out discrepancies between print media and public health. The objective of the present survey is to enhance the analysis of drug-related stories in the Brazilian print media, based on a new time frame, in the year 2000. Major newspapers and magazines of all Brazilian state capitals have been surveyed throughout year 2000, with 4,669 stories presenting drugs as their main topic. A random sample of 964 stories underwent content analysis. Approximately half the stories (49.6%) dealt with smuggling- and repression-related issues. The remainder of the stories (50.4%) approached health, legislation, and public policy issues. Tobacco was the most widely discussed drug, with stories focusing mainly on damage caused by use and on measures for reducing consumption rates among the population. Articles about cocaine, also featured frequently in the print media, dealt mainly with the issues of drug dealing and of damage caused by cocaine use. Regarding marijuana, in addition to the law enforcement repressive approach, some articles dealt with decriminalization and therapeutic use. Articles about alcoholic beverages, featured less frequently in the print media, approached the subject matter from various angles. The number of stories on solvents and psychotropic medication was negligible. The results confirm discrepancies between print media coverage and epidemiology. They also indicate that each drug is approached differently, allowing for a better understanding of the "social climate" in Brazil regarding each drug. Of all possible social interventions for dealing with the issue repression stands out, whereas stories about treatment and damage reduction are relatively scarce. These findings suggest the need for improved communication between journalists and health professionals.
Human Health Risk Assessment of Pharmaceuticals in Water: Issues and Challenges Ahead
Kumar, Arun; Chang, Biao; Xagoraraki, Irene
2010-01-01
This study identified existing issues related to quantitative pharmaceutical risk assessment (QPhRA, hereafter) for pharmaceuticals in water and proposed possible solutions by analyzing methodologies and findings of different published QPhRA studies. Retrospective site-specific QPhRA studies from different parts of the world (U.S.A., United Kingdom, Europe, India, etc.) were reviewed in a structured manner to understand different assumptions, outcomes obtained and issues, identified/addressed/raised by the different QPhRA studies. Till date, most of the published studies have concluded that there is no appreciable risk to human health during environmental exposures of pharmaceuticals; however, attention is still required to following identified issues: (1) Use of measured versus predicted pharmaceutical concentration, (2) Identification of pharmaceuticals-of-concern and compounds needing special considerations, (3) Use of source water versus finished drinking water-related exposure scenarios, (4) Selection of representative exposure routes, (5) Valuation of uncertainty factors, and (6) Risk assessment for mixture of chemicals. To close the existing data and methodology gaps, this study proposed possible ways to address and/or incorporation these considerations within the QPhRA framework; however, more research work is still required to address issues, such as incorporation of short-term to long-term extrapolation and mixture effects in the QPhRA framework. Specifically, this study proposed a development of a new “mixture effects-related uncertainty factor” for mixture of chemicals (i.e., mixUFcomposite), similar to an uncertainty factor of a single chemical, within the QPhRA framework. In addition to all five traditionally used uncertainty factors, this uncertainty factor is also proposed to include concentration effects due to presence of different range of concentration levels of pharmaceuticals in a mixture. However, further work is required to determine values of all six uncertainty factors and incorporate them to use during estimation of point-of-departure values within the QPhRA framework. PMID:21139869
Chung, Jane; Demiris, George; Thompson, Hilaire J
2016-01-01
With the wide adoption and use of smart home applications, there is a need for examining ethical issues regarding smart home use at the intersection of aging, technology, and home environment. The purpose of this review is to provide an overview of ethical considerations and the evidence on these ethical issues based on an integrative literature review with regard to the utilization of smart home technologies by older adults and their family members. REVIEW DESIGN AND METHODS: We conducted an integrative literature review of the scientific literature from indexed databases (e. g., MEDLINE, CINAHL, and PsycINFO). The framework guiding this review is derived from previous work on ethical considerations related to telehealth use for older adults and smart homes for palliative care. Key ethical issues of the framework include privacy, informed consent, autonomy, obtrusiveness, equal access, reduction in human touch, and usability. Six hundred and thirty-five candidate articles were identified between the years 1990 and 2014. Sixteen articles were included in the review. Privacy and obtrusiveness issues appear to be the most important factors that can affect smart home technology adoption. In addition, this article recommends that stigmatization and reliability and maintenance of the system are additional factors to consider. When smart home technology is used appropriately, it has the potential to improve quality of life and maintain safety among older adults, ultimately supporting the desire of older adults for aging in place. The ability to respond to potential ethical concerns will be critical to the future development and application of smart home technologies that aim to enhance safety and independence.
NASA Astrophysics Data System (ADS)
Weiss, N. K.; Wood, J. H.
2017-12-01
TThe Citizen Science Program H2O SOS: Help Heal the Ocean—Student Operated Solutions: Operation Climate Change, teaches middle and high school students about ocean threats related to climate change through hands-on activities and learning experiences in the field. During each session (in-class or after-school as a club), students build an understanding about how climate change impacts our oceans using resources provided by ExplorOcean (hands-on activities, presentations, multi-media). Through a student leadership model, students present lessons to each other, interweaving a deep learning of science, 21st century technology, communication skills, and leadership. After participating in learning experiences and activities related to 6 key climate change concepts: 1) Introduction to climate change, 2) Increased sea temperatures, 3) Ocean acidification, 4) Sea level rise, 5) Feedback mechanisms, and 6) Innovative solutions. H2O SOS- Operation Climate change participants select one focus issue and use it to design a multi-pronged campaign to increase awareness about this issue in their local community. The campaign includes social media, an interactive activity, and a visual component. All participating clubs that meet participation and action goals earn a field trip to Ocean Quest where they dive deeper into their selected issue through hands-on activities, real-world investigations, and interviews or presentations with experts. In addition to self-selected opportunities to showcase their focus issue, teams will participate in one of several key events identified by Ocean Quest.
Carlozzi, Noelle E; Tulsky, David S; Kisala, Pamela A
2011-10-01
This 2-part qualitative study explored health-related quality of life (HRQOL) in individuals with traumatic brain injury (TBI). A community-based participatory action research design was used, which emphasizes collaboration between researchers and individuals with disabilities to ensure that results are relevant for individuals with TBI. In study 1, community members (N=20) with TBI served as "experts" during 1-on-1 semistructured interviews, reviewing current HRQOL items and identifying HRQOL issues commonly experienced by individuals with TBI. Each participant identified at least 31 issues, with most generating more than 90 responses, highlighting the multifaceted nature of HRQOL in TBI. Study 2 consisted of 7 patient/consumer groups (33 individuals with TBI), 4 caregiver groups (17 caregivers), and 2 provider groups (15 providers). Qualitative analysis of patient focus groups indicated that 48% of focus group comments were related to emotional issues; 23%, to social functioning; 14%, to physical functioning; 11%, to cognition; and 7%, to personality changes (caregiver and provider focus group analysis indicated identical patterns of findings). In addition, both studies evaluated the applicability in TBI of generic items developed by the Patient-Reported Outcomes Measurement Information System and the Neurology Quality of Life Measurement initiative. Findings suggest that although there is some overlap between current generic measures of HRQOL and concepts reported by individuals with TBI, these generic measures do not capture the full complexity of HRQOL in TBI. TBI-targeted item banks are needed to ensure sensitive assessment of HRQOL in TBI. Copyright © 2011 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
Velez-Montoya, Raul; Oliver, Scott C N; Olson, Jeffrey L; Fine, Stuart L; Quiroz-Mercado, Hugo; Mandava, Naresh
2014-03-01
To address the most dynamic and current issues concerning human genetics, risk factors, pharmacoeconomics, and prevention regarding age-related macular degeneration. An online review of the database Pubmed and Ovid was performed, searching for the key words: age-related macular degeneration, AMD, pharmacoeconomics, risk factors, VEGF, prevention, genetics and their compound phrases. The search was limited to articles published since 1985 to date. All returned articles were carefully screened and their references were manually reviewed for additional relevant data. The webpage www.clinicaltrials.gov was also accessed in search of relevant research trials. A total of 366 articles were reviewed, including 64 additional articles extracted from the references and 25 webpages and online databases from different institutions. At the end, only 244 references were included in this review. Age-related macular degeneration is a complex multifactorial disease that has an uneven manifestation around the world but with one common denominator, it is increasing and spreading. The economic burden that this disease poses in developed nations will increase in the coming years. Effective preventive therapies need to be developed in the near future.
Treatment Issues for Aboriginal Mothers with Substance Use Problems and Their Children
Niccols, Allison; Dell, Colleen Anne; Clarke, Sharon
2014-01-01
In many cultures, approximately one third of people with drug dependence are women of child-bearing age. Substance use among pregnant and parenting women is a major public health concern. Aboriginal people have some of the highest rates of substance abuse in Canada, increasing concern for detrimental health impacts, including those for women and their children. For many women, substance abuse offers a means of coping with trauma, such as childhood abuse, partner violence, and, for Aboriginal women, the intergenerational effects of colonization. In this paper, we review treatment issues for Aboriginal mothers with substance use problems and their children. We discuss gender-specific issues in substance abuse, the need for women-specific treatment, the impact of substance abuse on children and parenting, the additional risks for Aboriginal women and children, and the need for integrated programs (those that integrate pregnancy-, parenting-, and child-related services with women-specific addiction treatment). We describe New Choices as an example of an integrated program, review research on existing treatment for Aboriginal mothers with substance use issues, and describe Sheway as a promising integrated program for Aboriginal women with substance abuse issues and their young children. There are few treatment programs specifically for Aboriginal mothers with substance use issues and their children and very little research on their effectiveness. Based on our review of existing evidence, we offer recommendations for future research and practice. PMID:24976814
Managing Nicaraguan Water Resources Definition and Relative Importance of Information Needs
DOE Office of Scientific and Technical Information (OSTI.GOV)
Engi, D.; Guillen, S.M.; Vammen, K.
1999-01-01
This report provides an overview of the results of the Vital the Nicaraguan Water Resources Management Initiative, Issues process as implemented for a collaborative effort between the Nicaraguan Ministry of Environment and Natural Resources and Sandia National Laboratories. This initiative is being developed to assist in the development of an efficient and sustainable water resources management system for Nicamgua. The Vital Issues process was used to provide information for developing a project that will develop and implement an advanced information system for managing Nicaragua's water resources. Three Vital Issues panel meetings were convened to 1) develop a mission statement andmore » evaluation criteria for identifying and ranking the issues vital to water resources management in Nicaragua 2) define and rank the vital issues; and 3) identify a preliminary list of information needed to address the vital issues. The selection of panelists from the four basic institutional perspectives- government, industiy, academe, and citizens' groups (through nongovernmental organizations (NGOs))-ensured a high level of stakeholder representation on the panels. The already existing need for a water resource management information system has been magnified in the aftemnath of Hurricane Mitch. This information system would be beneficial for an early warning system in emergencies, and the modeling and simulation capabilities of the system would allow for advanced planning. Additionally, the outreach program will provide education to help Nicaraguan improve their water hygiene practices.« less
Code of Federal Regulations, 2011 CFR
2011-10-01
..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS General Administration § 493.645 Additional fee(s) applicable to approved State laboratory programs and... laboratory programs and laboratories issued a certificate of accreditation, certificate of waiver, or...
40 CFR 35.4190 - How does my group identify a qualified technical advisor?
Code of Federal Regulations, 2011 CFR
2011-07-01
... issues or public health issues as those issues relate to hazardous substance/toxic waste issues, as... public health issues must have received his or her public health or related training at accredited... hazardous or toxic waste problems, relocation, redevelopment or public health issues, and communicating...
Code of Ethical Conduct for Computer-Using Educators: An ICCE Policy Statement.
ERIC Educational Resources Information Center
Computing Teacher, 1987
1987-01-01
Prepared by the International Council for Computers in Education's Ethics and Equity Committee, this code of ethics for educators using computers covers nine main areas: curriculum issues, issues relating to computer access, privacy/confidentiality issues, teacher-related issues, student issues, the community, school organizational issues,…
Edgren, Gustaf; Hjalgrim, Henrik
2010-11-01
At current safety levels, with adverse events from transfusions being relatively rare, further progress in risk reductions will require large-scale investigations. Thus, truly prospective studies may prove unfeasible and other alternatives deserve consideration. In this review, we will try to give an overview of recent and historical developments in the use of blood donation and transfusion databases in research. In addition, we will go over important methodological issues. There are at least three nationwide or near-nationwide donation/transfusion databases with the possibility for long-term follow-up of donors and recipients. During the past few years, a large number of reports have been published utilizing such data sources to investigate transfusion-associated risks. In addition, numerous clinics systematically collect and use such data on a smaller scale. Combining systematically recorded donation and transfusion data with long-term health follow-up opens up exciting opportunities for transfusion medicine research. However, the correct analysis of such data requires close attention to methodological issues, especially including the indication for transfusion and reverse causality.
Critical issues in an electronic documentation system.
Weir, Charlene R; Nebeker, Jonathan R
2007-10-11
The Veterans Health Administration (VHA), of the U.S. Department of Veteran Affairs has instituted a medical record (EMR) that includes electronic documentation of all narrative components of the medical record. To support clinicians using the system, multiple efforts have been instituted to ease the creation of narrative reports. Although electronic documentation is easier to read and improves access to information, it also may create new and additional hazards for users. This study is the first step in a series of studies to evaluate the issues surrounding the creation and use of electronic documentation. Eighty-eight providers across multiple clinical roles were interviewed in 10 primary care sites in the VA system. Interviews were tape-recorded, transcribed and qualitatively analyzed for themes. In addition, specific questions were asked about perceived harm due to electronic documentation practices. Five themes relating to difficulties with electronic documentation were identified: 1) information overload; 2) hidden information; 3) lack of trust; 4) communication; 5) decision-making. Three providers reported that they knew of an incident where current documentation practices had caused patient harm and over 75% of respondents reported significant mis-trust of the system.
Space Fission Propulsion System Development Status
NASA Technical Reports Server (NTRS)
Houts, Mike; VanDyke, Melissa; Godfroy, Tom; Pedersen, Kevin; Martin, James; Dickens, Ricky; Williams, Eric; Harper, Roger; Salvail, Pat; Hrbud, Ivana;
2001-01-01
The world's first man-made self-sustaining fission reaction was achieved in 1942. Since then fission has been used to propel submarines, generate tremendous amounts of electricity, produce medical isotopes, and provide numerous other benefits to society. Fission systems operate independently of solar proximity or orientation, and are thus well suited for deep spare or planetary surface missions. In addition, the fuel for fission systems (enriched uranium) is virtually non-radioactive. The primary safety issue with fission systems is avoiding inadvertent system start - addressing this issue through proper system design is straightforward. Despite the relative simplicity and tremendous potential of space fission systems, the development and utilization of these systems has proven elusive. The first use of fission technology in space occurred 3 April 1965 with the US launch of the SNAP-10A reactor. There have been no additional US uses of space fission system. While space fission system were used extensively by the former Soviet Union, their application was limited to earth-orbital missions. Early space fission systems must be safely and affordably utilized if Ae are to reap the benefits of advanced space fission systems.
Cayé-Thomasen, Per; Hermansson, Ann; Bakaletz, Lauren; Hellstrøm, Sten; Kanzaki, Sho; Kerschner, Joseph; Lim, David; Lin, Jizhen; Mason, Kevin; Spratley, Jorge
2013-04-01
The pathogenesis of otitis media (OM) involves a number of factors related to the anatomy, pathology, and cell biology of the middle ear, the mastoid, the Eustachian tube, and the nasopharynx. Although some issues of pathogenesis are fairly well established, others are only marginally indicated by current knowledge, and yet others remain undisclosed. The objective of this article is to provide a state-of-the-art review on recent scientific achievements in the pathogenesis of OM, as related to anatomy, pathology, and cell biology. PubMed, Ovid Medline, and Cochrane Library. Articles published on the pathogenesis of OM and the anatomy, pathology, and cell biology of the middle ear, the mastoid, the Eustachian tube, and the nasopharynx between January 2007 and June 2011 were identified. Among almost 1900 abstracts, the authors selected 130 articles for full article review and inclusion in this report. New knowledge on a number of issues emerged, including cell-specific expression and function of fluid transportation and innate immune system molecules, mucous cell metaplasia, mucin expression, bacterial adherence, and epithelial internalization, as well as the occurrence, composition, dynamics, and potential role of bacterial biofilm. In addition, the potential role of gastroesophageal reflux disease and cigarette smoke exposure has been explored further. Over the past 4 years, considerable scientific progress has been made on the pathogenesis of OM, as related to issues of anatomy, pathology, and cell biology. Based on these new achievements and a sustained lack of essential knowledge, suggestions for future research are outlined.
Sin, Kai; Pye, Mu; Meng, Hsien-Wen
2017-01-01
Objectives Refugees resettled in the US may be at risk for cardiovascular disease (CVD). However, little is known about CVD-related issues among Karen refugees who have migrated to the US from the Thai-Myanmar border. The purpose of this study was to examine CVD-related health beliefs and lifestyle issues among Karen refugees resettled in the US. Methods Karen refugees resettled in the US from the Thai-Myanmar border (n=195) participated in a survey study on health beliefs related to CVD, salt intake, physical activity (PA), and smoking in the fall of 2016. Results A high-salt diet, physical inactivity, and smoking were major lifestyle problems. Participants who adhered to a low-salt diet considered themselves to be susceptible to CVD. Most participants did not engage in regular PA. Regular PA was associated with less perceived susceptibility to CVD and greater perceived benefits of a healthy lifestyle for decreasing the likelihood of CVD. Conclusions Each refugee population may require individualized strategies to promote PA and a healthy diet. Future studies should develop health education programs that are specifically designed for Karen refugees and evaluate such programs. In addition to health education programs on healthy lifestyle choices, tobacco cessation programs seem to be necessary for Karen refugees. At the same time, it is important to foster strategies to increase the utilization of preventive care among this population by promoting free or reduced-fee resources in the community to further promote their health. PMID:29207451
Galactic cosmic ray simulation at the NASA Space Radiation Laboratory
Norbury, John W.; Schimmerling, Walter; Slaba, Tony C.; Azzam, Edouard I.; Badavi, Francis F.; Baiocco, Giorgio; Benton, Eric; Bindi, Veronica; Blakely, Eleanor A.; Blattnig, Steve R.; Boothman, David A.; Borak, Thomas B.; Britten, Richard A.; Curtis, Stan; Dingfelder, Michael; Durante, Marco; Dynan, William S.; Eisch, Amelia J.; Elgart, S. Robin; Goodhead, Dudley T.; Guida, Peter M.; Heilbronn, Lawrence H.; Hellweg, Christine E.; Huff, Janice L.; Kronenberg, Amy; La Tessa, Chiara; Lowenstein, Derek I.; Miller, Jack; Morita, Takashi; Narici, Livio; Nelson, Gregory A.; Norman, Ryan B.; Ottolenghi, Andrea; Patel, Zarana S.; Reitz, Guenther; Rusek, Adam; Schreurs, Ann-Sofie; Scott-Carnell, Lisa A.; Semones, Edward; Shay, Jerry W.; Shurshakov, Vyacheslav A.; Sihver, Lembit; Simonsen, Lisa C.; Story, Michael D.; Turker, Mitchell S.; Uchihori, Yukio; Williams, Jacqueline; Zeitlin, Cary J.
2017-01-01
Most accelerator-based space radiation experiments have been performed with single ion beams at fixed energies. However, the space radiation environment consists of a wide variety of ion species with a continuous range of energies. Due to recent developments in beam switching technology implemented at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), it is now possible to rapidly switch ion species and energies, allowing for the possibility to more realistically simulate the actual radiation environment found in space. The present paper discusses a variety of issues related to implementation of galactic cosmic ray (GCR) simulation at NSRL, especially for experiments in radiobiology. Advantages and disadvantages of different approaches to developing a GCR simulator are presented. In addition, issues common to both GCR simulation and single beam experiments are compared to issues unique to GCR simulation studies. A set of conclusions is presented as well as a discussion of the technical implementation of GCR simulation. PMID:26948012
Galactic cosmic ray simulation at the NASA Space Radiation Laboratory.
Norbury, John W; Schimmerling, Walter; Slaba, Tony C; Azzam, Edouard I; Badavi, Francis F; Baiocco, Giorgio; Benton, Eric; Bindi, Veronica; Blakely, Eleanor A; Blattnig, Steve R; Boothman, David A; Borak, Thomas B; Britten, Richard A; Curtis, Stan; Dingfelder, Michael; Durante, Marco; Dynan, William S; Eisch, Amelia J; Robin Elgart, S; Goodhead, Dudley T; Guida, Peter M; Heilbronn, Lawrence H; Hellweg, Christine E; Huff, Janice L; Kronenberg, Amy; La Tessa, Chiara; Lowenstein, Derek I; Miller, Jack; Morita, Takashi; Narici, Livio; Nelson, Gregory A; Norman, Ryan B; Ottolenghi, Andrea; Patel, Zarana S; Reitz, Guenther; Rusek, Adam; Schreurs, Ann-Sofie; Scott-Carnell, Lisa A; Semones, Edward; Shay, Jerry W; Shurshakov, Vyacheslav A; Sihver, Lembit; Simonsen, Lisa C; Story, Michael D; Turker, Mitchell S; Uchihori, Yukio; Williams, Jacqueline; Zeitlin, Cary J
2016-02-01
Most accelerator-based space radiation experiments have been performed with single ion beams at fixed energies. However, the space radiation environment consists of a wide variety of ion species with a continuous range of energies. Due to recent developments in beam switching technology implemented at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), it is now possible to rapidly switch ion species and energies, allowing for the possibility to more realistically simulate the actual radiation environment found in space. The present paper discusses a variety of issues related to implementation of galactic cosmic ray (GCR) simulation at NSRL, especially for experiments in radiobiology. Advantages and disadvantages of different approaches to developing a GCR simulator are presented. In addition, issues common to both GCR simulation and single beam experiments are compared to issues unique to GCR simulation studies. A set of conclusions is presented as well as a discussion of the technical implementation of GCR simulation. Published by Elsevier Ltd.
Clark, Timothy D; Sandblom, Erik; Jutfelt, Fredrik
2013-08-01
Measurements of aerobic scope [the difference between minimum and maximum oxygen consumption rate ( and , respectively)] are increasing in prevalence as a tool to address questions relating to fish ecology and the effects of climate change. However, there are underlying issues regarding the array of methods used to measure aerobic scope across studies and species. In an attempt to enhance quality control before the diversity of issues becomes too great to remedy, this paper outlines common techniques and pitfalls associated with measurements of , and aerobic scope across species and under different experimental conditions. Additionally, we provide a brief critique of the oxygen- and capacity-limited thermal tolerance (OCLTT) hypothesis, a concept that is intricately dependent on aerobic scope measurements and is spreading wildly throughout the literature despite little evidence for its general applicability. It is the intention of this paper to encourage transparency and accuracy in future studies that measure the aerobic metabolism of fishes, and to highlight the fundamental issues with assuming broad relevance of the OCLTT hypothesis.
JSC Director's Discretionary Fund Program
NASA Technical Reports Server (NTRS)
Jenkins, Lyle M. (Editor)
1991-01-01
The JSC Center Director's Discretionary Fund Program 1991 Annual Report provides a brief status of the projects undertaken during the 1991 fiscal year. For this year, four space exploration initiative related issues were focused on: regenerative life support, human spacecraft design, lunar surface habitat, and in situ resource utilization. In this way, a viable program of life sciences, space sciences, and engineering research has been maintained. For additional information on any single project, the individual investigator should be contacted.
Intellectual property and networked health information: issues and principles.
Cate, F H
1996-04-01
Information networks offer enormous potential for improving the delivery of health care services, facilitating health-related decision-making, and contributing to better health. In addition, advanced information technologies offer important opportunities for new markets, targeted information products and services, greater accessibility, lower costs and prices, and more rapid and efficient distribution. Realizing the full potential of those information resources requires the resolution of significant intellectual property issues, some of which may be affected by special features of health information. For example, the government is a significant funder and originator of health-related information. In addition, much of that information is of great importance to the population and benefits not only individual users, but also employers, insurance companies, the government, and society as a whole. The government must therefore continue to provide particularly important health information to the public, and facilitate that information's accessibility and reliability, while avoiding unnecessary competition with private information providers. Congress and courts must modify or interpret current copyright law as necessary to guarantee that it does not interfere with innovation in tailored health information or exceed its constitutional boundaries and restrict access to information, as opposed to expression. Both producers and users of information must work with the government to educate the public about the availability of health information and the rights of and limitations upon users under copyright law.
Intellectual property and networked health information: issues and principles.
Cate, F H
1996-01-01
Information networks offer enormous potential for improving the delivery of health care services, facilitating health-related decision-making, and contributing to better health. In addition, advanced information technologies offer important opportunities for new markets, targeted information products and services, greater accessibility, lower costs and prices, and more rapid and efficient distribution. Realizing the full potential of those information resources requires the resolution of significant intellectual property issues, some of which may be affected by special features of health information. For example, the government is a significant funder and originator of health-related information. In addition, much of that information is of great importance to the population and benefits not only individual users, but also employers, insurance companies, the government, and society as a whole. The government must therefore continue to provide particularly important health information to the public, and facilitate that information's accessibility and reliability, while avoiding unnecessary competition with private information providers. Congress and courts must modify or interpret current copyright law as necessary to guarantee that it does not interfere with innovation in tailored health information or exceed its constitutional boundaries and restrict access to information, as opposed to expression. Both producers and users of information must work with the government to educate the public about the availability of health information and the rights of and limitations upon users under copyright law. PMID:8826629
Multi-Unit Considerations for Human Reliability Analysis
DOE Office of Scientific and Technical Information (OSTI.GOV)
St. Germain, S.; Boring, R.; Banaseanu, G.
This paper uses the insights from the Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) methodology to help identify human actions currently modeled in the single unit PSA that may need to be modified to account for additional challenges imposed by a multi-unit accident as well as identify possible new human actions that might be modeled to more accurately characterize multi-unit risk. In identifying these potential human action impacts, the use of the SPAR-H strategy to include both errors in diagnosis and errors in action is considered as well as identifying characteristics of a multi-unit accident scenario that may impact themore » selection of the performance shaping factors (PSFs) used in SPAR-H. The lessons learned from the Fukushima Daiichi reactor accident will be addressed to further help identify areas where improved modeling may be required. While these multi-unit impacts may require modifications to a Level 1 PSA model, it is expected to have much more importance for Level 2 modeling. There is little currently written specifically about multi-unit HRA issues. A review of related published research will be presented. While this paper cannot answer all issues related to multi-unit HRA, it will hopefully serve as a starting point to generate discussion and spark additional ideas towards the proper treatment of HRA in a multi-unit PSA.« less
Energy, The Environment And Astronomy: Education And Action
NASA Astrophysics Data System (ADS)
Rodgers, Bernadette; Doppmann, G.; Kalas, P.; Lacy, J.; Beck, T.; Marshall, P. J.
2010-01-01
The specter of global climate change is arguably the most pressing scientific, social and ethical issue of our time. Although the relatively small field of astronomy represents only a fraction of the total human carbon emissions, astronomers have a great potential, and therefore perhaps a great responsibility, to educate themselves and the public on this issue. In addition, the average per capita carbon emissions of professional astronomers are not small, and our profession can do much to reduce its energy consumption and maximize the cost-benefit ratio of our work. At the January AAS meeting, we are organizing a half-day splinter meeting titled "Energy, the Environment and Astronomy: Education and Action". The focus will be on energy conservation and education as it relates to professional astronomy. Education focuses on informing ourselves, our students and the general public with which we interact, about the real issues, the necessary actions, and the likely consequences of various energy consumption and carbon emission scenarios. Action focuses on effective energy conservation and renewable energy initiatives within professional astronomy. Air travel, solar energy at ground-based observatories, and Gemini's "Green Initiative” are among the topics that will be discussed. The splinter meeting will be open to all and will include expert speakers from outside astronomy, contributed talks by astronomers, and a discussion session.
Writing Stories to Enhance Scientific Literacy
NASA Astrophysics Data System (ADS)
Ritchie, Stephen M.; Tomas, Louisa; Tones, Megan
2011-03-01
In response to international concerns about scientific literacy and students' waning interest in school science, this study investigated the effects of a science-writing project about the socioscientific issue (SSI) of biosecurity on the development of students' scientific literacy. Students generated two BioStories each that merged scientific information with the narrative storylines in the project. The study was conducted in two phases. In the exploratory phase, a qualitative case study of a sixth-grade class involving classroom observations and interviews informed the design of the second, confirmatory phase of the study, which was conducted at a different school. This phase involved a mixed methods approach featuring a quasi-experimental design with two classes of Australian middle school students (i.e., sixth grade, 11 years of age, n = 55). The results support the argument that writing the sequence of stories helped the students become more familiar with biosecurity issues, develop a deeper understanding of related biological concepts, and improve their interest in science. On the basis of these findings, teachers should be encouraged to engage their students in the practice of writing about SSI in a way that integrates scientific information into narrative storylines. Extending the practice to older students and exploring additional issues related to writing about SSI are recommended for further research.
Indigenous Affairs = Asuntos Indigenas, 2000.
ERIC Educational Resources Information Center
Indigenous Affairs, 2000
2000-01-01
This document contains the four English-language issues of Indigenous Affairs published in 2000 and four corresponding issues in Spanish. The Spanish issues contain all or some of the articles contained in the English issues plus additional articles on Latin America. These periodicals provide a resource on the history, current conditions, and…
NASA Astrophysics Data System (ADS)
Blasch, Erik; Salerno, John; Kadar, Ivan; Yang, Shanchieh J.; Fenstermacher, Laurie; Endsley, Mica; Grewe, Lynne
2013-05-01
During the SPIE 2012 conference, panelists convened to discuss "Real world issues and challenges in Human Social/Cultural/Behavioral modeling with Applications to Information Fusion." Each panelist presented their current trends and issues. The panel had agreement on advanced situation modeling, working with users for situation awareness and sense-making, and HSCB context modeling in focusing research activities. Each panelist added different perspectives based on the domain of interest such as physical, cyber, and social attacks from which estimates and projections can be forecasted. Also, additional techniques were addressed such as interest graphs, network modeling, and variable length Markov Models. This paper summarizes the panelists discussions to highlight the common themes and the related contrasting approaches to the domains in which HSCB applies to information fusion applications.
Putting 'addiction' back into psychiatry: the RANZCP Section of Addiction Psychiatry.
Lubman, Dan; Jurd, Stephen; Baigent, Michael; Krabman, Peter
2008-02-01
The aim of this paper is to provide an overview of the history and activities of the RANZCP Section of Addiction Psychiatry, as well as its current challenges and opportunities. From initial exclusion to an active and growing membership, the Section of Addiction Psychiatry continues to ensure that problematic substance use and gambling remain core issues within Australasian psychiatry. In addition to commenting and contributing to ongoing clinical and policy initiatives, the Section has recently introduced an advanced training curriculum and maintains a strong partnership with the relatively new Australasian Chapter of Addiction Medicine. Its active input into education, training, media and policy development within the College guarantees that psychiatry is represented within the addiction field, and that tomorrow's psychiatrists are competent to assess and treat comorbid addiction issues.
Treating older adults with cancer: geriatric perspectives.
Klepin, Heidi D; Rodin, Miriam; Hurria, Arti
2015-01-01
The proportion of older adults (age 65 and older) in oncology practices continues to increase. Older adults present with unique issues that complicate management decisions and evidence from randomized clinical trials to inform management of these patients is lacking. Despite this, principles of geriatric medicine need to be incorporated into oncology practice to provide optimal individualized care to patients. There is increasing evidence from observational studies that geriatric assessment (GA) strategies can be applied in oncology, can help predict treatment outcomes, and can inform supportive care management for older adults. In this review, we discuss the principles of GA and their use in older adults with cancer. In addition, considerations on when to refer to a geriatrician and issues related to management of vulnerable older adults will be addressed.
Man-machine interface analysis of the flight design system
NASA Technical Reports Server (NTRS)
Ramsey, H. R.; Atwood, M. E.; Willoughby, J. K.
1978-01-01
The objective of the current effort was to perform a broad analysis of the human factors issues involved in the design of the Flight Design System (FDS). The analysis was intended to include characteristics of the system itself, such as: (1) basic structure and functional capabilities of FDS; (2) user backgrounds, capabilities, and possible modes of use; (3) FDS interactive dialogue, problem solving aids; (4) system data management capabilities; and to include, as well, such system related matters as: (1) flight design team structure; (2) roles of technicians; (3) user training; and (4) methods of evaluating system performance. Wherever possible, specific recommendations are made. In other cases, the issues which seem most important are identified. In some cases, additional analyses or experiments which might provide resolution are suggested.
Security analysis of RSA cryptosystem algorithm and it’s properties
DOE Office of Scientific and Technical Information (OSTI.GOV)
Liu, Chenglian; Guo, Yongning, E-mail: guoyn@163.com, E-mail: linjuanliucaihong@qq.com; Lin, Juan, E-mail: guoyn@163.com, E-mail: linjuanliucaihong@qq.com
2014-10-06
The information technology rapidly development and dramatically changed the life style people, in addition to shortening the distance of communication, but also promote the smooth exchange of information flows. However, derivatives to facilitate the relative safety of these issues, since into the digital information age, the majority of the practitioners of engineering and technical personnel and technical workers in terms of technology, information security is increasingly becoming an important issue. The RSA algorithm was published in 1978. It is a kind of very popular and widely application modem cryptosystem in the world. Even though there are lots of articles tomore » discuss about how to break the RSA, but it is still secure today. In this paper, the authors would like to introduce a variant attack to RSA.« less
Li, Lei; Yu, Miao; Jia, Chao; Liu, Jianxin; Lv, Yanyan; Liu, Yanhua; Zhou, Yi; Liu, Chuanting; Shao, Ziqiang
2017-06-21
Safety issues are critical barriers to large-scale energy storage applications of lithium-ion batteries (LIBs). Using an ameliorated, thermally stable, shutdown separator is an effective method to overcome the safety issues. Herein, we demonstrate a novel, cellulosic biomass-material-blended polyvinylidene fluoride separator that was prepared using a simple nonsolvent-induced phase separation technique. This process formed a microporous composite separator with reduced crystallinity, uniform pore size distribution, superior thermal tolerance, and enhanced electrolyte wettability and dielectric and mechanical properties. In addition, the separator has a superior capacity retention and a better rate capability compared to the commercialized microporous polypropylene membrane. This fascinating membrane was fabricated via a relatively eco-friendly and cost-effective method and is an alternative, promising separator for high-power LIBs.
Sušnik, Janez; Vamvakeridou-Lyroudia, Lydia S; Baumert, Niklas; Kloos, Julia; Renaud, Fabrice G; La Jeunesse, Isabelle; Mabrouk, Badr; Savić, Dragan A; Kapelan, Zoran; Ludwig, Ralf; Fischer, Georg; Roson, Roberto; Zografos, Christos
2015-01-15
CLImate-induced changes on WAter and SECurity (CLIWASEC) was a cluster of three complementary EC-FP7 projects assessing climate-change impacts throughout the Mediterranean on: hydrological cycles (CLIMB - CLimate-Induced changes on the hydrology of Mediterranean Basins); water security (WASSERMed - Water Availability and Security in Southern EuRope and the Mediterranean) and human security connected with possible hydro-climatic conflicts (CLICO - CLImate change hydro-COnflicts and human security). The Nile delta case study was common between the projects. CLIWASEC created an integrated forum for modelling and monitoring to understand potential impacts across sectors. This paper summarises key results from an integrated assessment of potential challenges to water-related security issues, focusing on expected sea-level rise impacts by the middle of the century. We use this common focus to illustrate the added value of project clustering. CLIWASEC pursued multidisciplinary research by adopting a single research objective: sea-level rise related water security threats, resulting in a more holistic view of problems and potential solutions. In fragmenting research, policy-makers can fail to understand how multiple issues can materialize from one driver. By combining efforts, an integrated assessment of water security threats in the lower Nile is formulated, offering policy-makers a clearer picture of inter-related issues to society and environment. The main issues identified by each project (land subsidence, saline intrusion - CLIMB; water supply overexploitation, land loss - WASSERMed; employment and housing security - CLICO), are in fact related. Water overexploitation is exacerbating land subsidence and saline intrusion, impacting on employment and placing additional pressure on remaining agricultural land and the underdeveloped housing market. All these have wider implications for regional development. This richer understanding could be critical in making better policy decisions when attempting to mitigate climate and social change impacts. The CLIWASEC clustering offers an encouraging path for the new European Commission Horizon 2020 programme to follow. Copyright © 2014 Elsevier B.V. All rights reserved.
Guise, Veslemøy; Anderson, Janet; Wiig, Siri
2014-11-25
Patient safety risk in the homecare context and patient safety risk related to telecare are both emerging research areas. Patient safety issues associated with the use of telecare in homecare services are therefore not clearly understood. It is unclear what the patient safety risks are, how patient safety issues have been investigated, and what research is still needed to provide a comprehensive picture of risks, challenges and potential harm to patients due to the implementation and use of telecare services in the home. Furthermore, it is unclear how training for telecare users has addressed patient safety issues. A systematic review of the literature was conducted to identify patient safety risks associated with telecare use in homecare services and to investigate whether and how these patient safety risks have been addressed in telecare training. Six electronic databases were searched in addition to hand searches of key items, reference tracking and citation tracking. Strict inclusion and exclusion criteria were set. All included items were assessed according to set quality criteria and subjected to a narrative synthesis to organise and synthesize the findings. A human factors systems framework of patient safety was used to frame and analyse the results. 22 items were included in the review. 11 types of patient safety risks associated with telecare use in homecare services emerged. These are in the main related to the nature of homecare tasks and practices, and person-centred characteristics and capabilities, and to a lesser extent, problems with the technology and devices, organisational issues, and environmental factors. Training initiatives related to safe telecare use are not described in the literature. There is a need to better identify and describe patient safety risks related to telecare services to improve understandings of how to avoid and minimize potential harm to patients. This process can be aided by reframing known telecare implementation challenges and user experiences of telecare with the help of a human factors systems approach to patient safety.
Additive manufacturing for steels: a review
NASA Astrophysics Data System (ADS)
Zadi-Maad, A.; Rohib, R.; Irawan, A.
2018-01-01
Additive manufacturing (AM) of steels involves the layer by layer consolidation of powder or wire feedstock using a heating beam to form near net shape products. For the past decades, the AM technique reaches the maturation of both research grade and commercial production due to significant research work from academic, government and industrial research organization worldwide. AM process has been implemented to replace the conventional process of steel fabrication due to its potentially lower cost and flexibility manufacturing. This paper provides a review of previous research related to the AM methods followed by current challenges issues. The relationship between microstructure, mechanical properties, and process parameters will be discussed. Future trends and recommendation for further works are also provided.
Sperm competition, immunity, selfish genes and cancer.
Lewis, Z; Price, T A R; Wedell, N
2008-10-01
Sperm competition is widespread and has played an important role in shaping male reproductive characters such as testis size and numbers of sperm produced, and this is reflected in the rapid evolution of many reproductive genes. Additionally, sperm competition has been implicated in the rapid evolution of seminal fluids. However, our understanding of the molecular basis of many traits thought to be important in sperm competition is rudimentary. Furthermore, links between sperm competition and a range of issues not directly related to reproduction are only just beginning to be explored. These include associations between sperm competition and selfish genes, immunity and diseases such as cancer.We briefly review these topics and suggest areas we consider worthy of additional research.
Thomson, H J; Winters, Z E; Brandberg, Y; Didier, F; Blazeby, J M; Mills, J
2013-03-01
A comprehensive evaluation of breast reconstruction (BRR) surgery includes measurement of patient reported outcomes (PROs). There is, however, a lack of validated BRR-specific PRO measures (PROMs) that adequately assess relevant issues. This study is developing a European Organisation for Research and Treatment of Cancer (EORTC) questionnaire/module specific for PROs in BRR to supplement the cancer-core and breast cancer EORTC questionnaires, respectively: the QLQ-C30 and QLQ-BR23. Phases I and II of questionnaire development followed EORTC guidelines including a systematic literature review to identify all potential 'issues' (concepts relevant to PROs) and semi-structured interviews with 89 patients and 9 European multi-disciplinary health care professionals (HCPs) (Sweden, Italy and the United Kingdom [UK]). Interviewers asked participants the 'relevance' of outcomes identified in the literature and captured additional 'issues' of importance. The literature search and interviews of patients and HCPs yielded 69 issues relating to BRR operationalised into 31 provisional items (single questions) for the module, which was conceptualised to contain five scales: treatment/surgery related symptoms (affecting the shoulder, arm and reconstructed breast), body image, sexuality, cosmetic outcomes (pertaining to three areas: breast, donor site and nipple) and overall satisfaction. The provisional development of the EORTC BRR module has 31 items addressing issues of importance to patients as well as HCPs. Further international testing is underway as a UK National Cancer Research Network trial to ensure that this PROM will be psychometrically and clinically robust and applicable for use in clinical trials, cohort studies, national audit and clinical practice. Copyright © 2012 Elsevier Ltd. All rights reserved.
Media ownership and news framing: an analysis of HIV/AIDS coverage by Ugandan press.
Kiwanuka-Tondo, James; Albada, Kelly F; Payton, Fay Cobb
2012-12-01
Applying framing theory, the present research analyzes trends in Ugandan news coverage and the prominent issue frames for HIV/AIDS-related stories. In order to determine the influence of other factors, such as media ownership and journalist origin, nearly 800 articles, from 2000 to 2004, were gathered from the major private newspaper and government-owned newspaper in Uganda. After systematic sampling, 365 articles constitute the sample. The results indicate that print news coverage of HIV and AIDS followed a non-linear trajectory, declining from 2000-2002 and then increasing from 2003-2004. Curative medicine emerged as the most prominent issue frame. Higher-risk behaviour was the least prominent issue frame overall. The 'solutions' issue frame nearly doubled in prominence from 2000-2004, while the HIV-prevention frame decreased from 2000-2002 and then rebounded from 2003-2004. Concerning HIV-related topics, the private newspaper included more features, printed lengthier articles, incorporated a greater variety of news frames, and published more articles by foreign journalists than the government-owned newspaper. The private newspaper employed the 'HIV-prevention,' 'action,' and 'victims' frames more often than the government-owned newspaper. Journalists at the government-owned newspaper adopted a 'solutions' frame more often than their private-press counterparts. Though foreign journalists were more likely than local journalists to employ the HIV-prevention frame, additional tests revealed that the news organisation for which the journalists worked contributed to issue framing to a greater extent than did either a local or foreign reporting origin. Local (Ugandan) journalists working for the two news organisations differed in their tendencies to apply the HIV-prevention, action, victims, and tragedy frames in news stories on HIV and AIDS, with journalists at the private newspaper using these frames more often than did journalists at the government-owned newspaper.
Supporting Cancer Patients in Illness Management: Usability Evaluation of a Mobile App
Kaufman, David R; Ruland, Cornelia M
2014-01-01
Background Mobile phones and tablets currently represent a significant presence in people’s everyday lives. They enable access to different information and services independent of current place and time. Such widespread connectivity offers significant potential in different app areas including health care. Objective Our goal was to evaluate the usability of the Connect Mobile app. The mobile app enables mobile access to the Connect system, an online system that supports cancer patients in managing health-related issues. Along with symptom management, the system promotes better patient-provider communication, collaboration, and shared decision making. The Connect Mobile app enables access to the Connect system over both mobile phones and tablets. Methods The study consisted of usability tests of a high fidelity prototype with 7 cancer patients where the objectives were to identify existing design and functionality issues and to provide patients with a real look-and-feel of the mobile system. In addition, we conducted semistructured interviews to obtain participants’ feedback about app usefulness, identify the need for new system features and design requirements, and measure the acceptance of the mobile app and its features within everyday health management. Results The study revealed a total of 27 design issues (13 for mobile apps and 14 for tablet apps), which were mapped to source events (ie, errors, requests for help, participants' concurrent feedback, and moderator observation). We also applied usability heuristics to identify violations of usability principles. The majority of violations were related to enabling ease of input, screen readability, and glanceability (15 issues), as well as supporting an appropriate match between systems and the real world (7 issues) and consistent mapping of system functions and interactions (4 issues). Feedback from participants also showed the cancer patients’ requirements for support systems and how these needs are influenced by different context-related factors, such as type of access terminal (eg, desktop computer, tablet, mobile phone) and phases of illness. Based on the observed results, we proposed design and functionality recommendations that can be used for the development of mobile apps for cancer patients to support their health management process. Conclusions Understanding and addressing users’ requirements is one of the main prerequisites for developing useful and effective technology-based health interventions. The results of this study outline different user requirements related to the design of the mobile patient support app for cancer patients. The results will be used in the iterative development of the Connect Mobile app and can also inform other developers and researchers in development, integration, and evaluation of mobile health apps and services that support cancer patients in managing their health-related issues. PMID:25119490
Elhadad, N.
2016-01-01
Summary Objectives This paper reviews work over the past two years in Natural Language Processing (NLP) applied to clinical and consumer-generated texts. Methods We included any application or methodological publication that leverages text to facilitate healthcare and address the health-related needs of consumers and populations. Results Many important developments in clinical text processing, both foundational and task-oriented, were addressed in community-wide evaluations and discussed in corresponding special issues that are referenced in this review. These focused issues and in-depth reviews of several other active research areas, such as pharmacovigilance and summarization, allowed us to discuss in greater depth disease modeling and predictive analytics using clinical texts, and text analysis in social media for healthcare quality assessment, trends towards online interventions based on rapid analysis of health-related posts, and consumer health question answering, among other issues. Conclusions Our analysis shows that although clinical NLP continues to advance towards practical applications and more NLP methods are used in large-scale live health information applications, more needs to be done to make NLP use in clinical applications a routine widespread reality. Progress in clinical NLP is mirrored by developments in social media text analysis: the research is moving from capturing trends to addressing individual health-related posts, thus showing potential to become a tool for precision medicine and a valuable addition to the standard healthcare quality evaluation tools. PMID:27830255
1993-06-01
Renal transplantation is considered now the definitive treatment for patients with end-stage renal disease (ESRD). Unfortunately, the worldwide shortage of kidneys remains the most important obstacle to transplantation. In developing countries, including those of the Middle East, the shortage is even more dramatic. Despite great efforts to establish and maintain successful transplant centers, the number of kidneys that have been transplanted in the last few years has actually declined. The lack of a dependable kidney source played well into the hands of unscrupulous entrepreneurs who started brokerage of organs for profit. In this practice, patients with ESRD travel to India and other countries to purchase kidneys from living genetically non-related poor donors. Patient care was therefore relegated to the laws of the marketplace and both patients and donors were exploited to maximize profit. Additionally, reported results of this type of transplantation were inferior to those of other types of transplantation. Not unexpectedly, these issues have created intense controversy among transplant physicians and the general public in which moral, ethical and medical issues were debated. To investigate these issues, we conducted a large multicenter study in Saudi Arabia, Bahrain and Egypt. In the first phase of this study, we surveyed 50 institutions regarding their attitude toward LNRRT, of which 22 responded. The results of our survey clearly show that patients with ESRD take the initiative in seeking LNRRT despite physician discouragement and significant financial burden.(ABSTRACT TRUNCATED AT 250 WORDS)
Trezzini, Bruno; Phillips, Barbara
2014-01-01
To identify research gaps and potential research priorities regarding the impact that legal regulations and administrative policies might have on people with spinal cord injury (SCI) living in Switzerland. We conducted semi-structured interviews with 14 healthcare professionals working for or being associated with the largest SCI clinic in Switzerland. The transcribed interviews were content analyzed, involving qualitative description, and thematic analysis techniques. Four interrelated clusters of issues were corroborated: (1) social insurance, (2) caregiving, (3) work integration, and (4) aging. In addition, two overarching themes were identified: (1) fairness considerations and (2) unavailability of systematic empirical evidence. Work capacity assessment and family caregiving were deemed to be the most pressing research priority areas. Legal frameworks do play both a direct and an indirect role in the lives of people with SCI in Switzerland. This is particularly true with regard to various issues related to the social insurance system, such as family caregiving and work capacity assessment. The salience of these topics is closely related to major sociodemographic and political driving forces, i.e. aging and social insurance reforms. Research directly involving people with SCI is needed to further substantiate and refine the findings of this study. When dealing with issues related to work reintegration, aging, social insurance, and caregiving, rehabilitation professionals should take existing legal frameworks into account. Eligibility criteria for disability benefits may influence the therapy motivation of rehabilitation clients.
Time-dependent modeling of dust injection in semi-detached ITER divertor plasma
NASA Astrophysics Data System (ADS)
Smirnov, Roman; Krasheninnikov, Sergei
2017-10-01
At present, it is generally understood that dust related issues will play important role in operation of the next step fusion devices, i.e. ITER, and in the development of future fusion reactors. Recent progress in research on dust in magnetic fusion devises has outlined several topics of particular concern: a) degradation of fusion plasma performance; b) impairment of in-vessel diagnostic instruments; and c) safety issues related to dust reactivity and tritium retention. In addition, observed dust events in fusion edge plasmas are highly irregular and require consideration of temporal evolution of both the dust and the fusion plasma. In order to address the dust-related fusion performance issues, we have coupled the dust transport code DUSTT and the edge plasma transport code UEDGE in time-dependent manner, allowing modeling of transient dust-induced phenomena in fusion edge plasmas. Using the coupled codes we simulate burst-like injection of tungsten dust into ITER divertor plasma in semi-detached regime, which is considered as preferable ITER divertor operational mode based on the plasma and heat load control restrictions. Analysis of transport of the dust and the dust-produced impurities, and of dynamics of the ITER divertor and edge plasma in response to the dust injection will be presented. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Fusion Energy Sciences, under Award Number DE-FG02-06ER54852.
Relative arrival-time upper-mantle tomography and the elusive background mean
NASA Astrophysics Data System (ADS)
Bastow, Ian D.
2012-08-01
The interpretation of seismic tomographic images of upper-mantle seismic wave speed structure is often a matter of considerable debate because the observations can usually be explained by a range of hypotheses, including variable temperature, composition, anisotropy, and the presence of partial melt. An additional problem, often overlooked in tomographic studies using relative as opposed to absolute arrival-times, is the issue of the resulting velocity model's zero mean. In shield areas, for example, relative arrival-time analysis strips off a background mean velocity structure that is markedly fast compared to the global average. Conversely, in active areas, the background mean is often markedly slow compared to the global average. Appreciation of this issue is vital when interpreting seismic tomographic images: 'high' and 'low' velocity anomalies should not necessarily be interpreted, respectively, as 'fast' and 'slow' compared to 'normal mantle'. This issue has been discussed in the seismological literature in detail over the years, yet subsequent tomography studies have still fallen into the trap of mis-interpreting their velocity models. I highlight here some recent examples of this and provide a simple strategy to address the problem using constraints from a recent global tomographic model, and insights from catalogues of absolute traveltime anomalies. Consultation of such absolute measures of seismic wave speed should be routine during regional tomographic studies, if only for the benefit of the broader Earth Science community, who readily follow the red = hot and slow, blue = cold and fast rule of thumb when interpreting the images for themselves.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-05
... additional information, and issuing decision notices and/or proofs of benefit. This notice updates this... evidence or additional information, and issuing decision notices and/or proofs of benefit. This system of... Temporary Accounts and Draft Benefit Requests), which stores draft account and case information from...
Real-time earthquake monitoring: Early warning and rapid response
NASA Technical Reports Server (NTRS)
1991-01-01
A panel was established to investigate the subject of real-time earthquake monitoring (RTEM) and suggest recommendations on the feasibility of using a real-time earthquake warning system to mitigate earthquake damage in regions of the United States. The findings of the investigation and the related recommendations are described in this report. A brief review of existing real-time seismic systems is presented with particular emphasis given to the current California seismic networks. Specific applications of a real-time monitoring system are discussed along with issues related to system deployment and technical feasibility. In addition, several non-technical considerations are addressed including cost-benefit analysis, public perceptions, safety, and liability.
Acute Neurological Issues in Pregnancy and the Peripartum
Hosley, Catherine M.; McCullough, Louise D.
2011-01-01
Acute neurological diseases requiring hospitalization are relatively rare in women of childbearing age. However, during pregnancy and the postpartum period, several diseases increase in prevalence. Some are unique to the pregnant/postpartum state including preeclampsia and delivery-associated neuropathies. Others, although indirectly related to pregnancy, such as cerebral venous thrombosis, ischemic stroke, and intracerebral hemorrhage, increase in frequency and carry considerable risk of morbidity and mortality. In addition, treatment options are often limited. This review discusses the diseases more commonly seen during pregnancy and the postpartum period, with a focus on emergent neurological diseases and their management. Interventional therapies will also be discussed. PMID:23983844
Susceptibility to acoustic trauma in young and aged gerbils
NASA Astrophysics Data System (ADS)
Boettcher, Flint A.
2002-12-01
The effect of age on susceptibility to noise-induced hearing loss (NIHL), the effect of gender on the interaction of age-related hearing loss (ARHL) and NIHL, and the relative contributions of ARHL and NIHL to total hearing loss are poorly understood. The issues are difficult to resolve empirically in human subjects because of lack of control over extrinsic variables and for ethical reasons. Accordingly, these issues were examined in a well-studied animal model of both ARHL and NIHL, the Mongolian gerbil. Animals were exposed to an intense tone (3.5 kHz, 113 dB SPL, 1 h) either as young adults (6-8 months) or near the end of the average lifespan of the species (34-38 months). Hearing thresholds were determined with the auditory brainstem response (ABR). ARHL was approximately 5-10 dB, with slightly more observed in males at 16 kHz (p<0.05). NIHL of approximately 15-20 dB was similar for the young and old groups, suggesting no differences in susceptibility as a function of age. There were no gender differences in NIHL. The relative contributions of ARHL and NIHL to total hearing loss in aged, noise-exposed gerbils were predicted by an addition of ARHL and NIHL in dB, similar to an international standard on hearing loss allocation, ISO-1999 [Determination of Occupational Noise Exposure and Estimation of Noise-Induced Hearing Impairment (1990)]. Previous evaluations of ISO-1999 using the gerbil animal model concluded that addition of ARHL and NIHL in dB overpredicts total hearing loss. However, in these studies, ARHL was large and nearly equal to NIHL. In the current study, where ARHL was much less than NIHL, addition of the two factors in dB, as recommended by ISO-1999, results in fairly accurate predictions of total hearing loss.
Thematic relatedness production norms for 100 object concepts.
Jouravlev, Olessia; McRae, Ken
2016-12-01
Knowledge of thematic relations is an area of increased interest in semantic memory research because it is crucial to many cognitive processes. One methodological issue that researchers face is how to identify pairs of thematically related concepts that are well-established in semantic memory for most people. In this article, we review existing methods of assessing thematic relatedness and provide thematic relatedness production norming data for 100 object concepts. In addition, 1,174 related concept pairs obtained from the production norms were classified as reflecting one of the five subtypes of relations: attributive, argument, coordinate, locative, and temporal. The database and methodology will be useful for researchers interested in the effects of thematic knowledge on language processing, analogical reasoning, similarity judgments, and memory. These data will also benefit researchers interested in investigating potential processing differences among the five types of semantic relations.
Brandänge, Kristina; Gustavsson, J. Petter
2000-01-01
Just after midnight on the 28th of September 1994, the Estonian-flagged ro-ro passenger ferry MV Estonia was shipwrecked on its route between Tallinn and Stockholm. Out of about 1000 persons on board only 137 survived. This paper describes the work that the Psychiatric Clinic at Ersta Hospital performed with the relatives of the MV Estonia victims after the disaster, in addition, we present data from seven consecutive Swedish nationwide surveys based on a questionnaire, which started as a correspondence between the hospital and the relatives of the Estonia victims. Findings concerning the care relatives received and issues regarding their collaboration with the decisionmaking authorities are presented. The importance of inviting the relatives to participate in discussions concerning the Estonia victims is stressed. PMID:22034392
Conceptual framework for behavioral and social science in HIV vaccine clinical research
Lau, Chuen-Yen; Swann, Edith M.; Singh, Sagri; Kafaar, Zuhayr; Meissner, Helen I.; Stansbury, James P.
2011-01-01
HIV vaccine clinical research occurs within a context where biomedical science and social issues are interlinked. Previous HIV vaccine research has considered behavioral and social issues, but often treated them as independent of clinical research processes. Systematic attention to the intersection of behavioral and social issues within a defined clinical research framework is needed to address gaps, such as those related to participation in trials, completion of trials, and the overall research experience. Rigorous attention to these issues at project inception can inform trial design and conduct by matching research approaches to the context in which trials are to be conducted. Conducting behavioral and social sciences research concurrent with vaccine clinical research is important because it can help identify potential barriers to trial implementation, as well as ultimate acceptance and dissemination of trial results. We therefore propose a conceptual framework for behavioral and social science in HIV vaccine clinical research and use examples from the behavioral and social science literature to demonstrate how the model can facilitate identification of significant areas meriting additional exploration. Standardized use of the conceptual framework could improve HIV vaccine clinical research efficiency and relevance. PMID:21821083
Conceptual framework for behavioral and social science in HIV vaccine clinical research.
Lau, Chuen-Yen; Swann, Edith M; Singh, Sagri; Kafaar, Zuhayr; Meissner, Helen I; Stansbury, James P
2011-10-13
HIV vaccine clinical research occurs within a context where biomedical science and social issues are interlinked. Previous HIV vaccine research has considered behavioral and social issues, but often treated them as independent of clinical research processes. Systematic attention to the intersection of behavioral and social issues within a defined clinical research framework is needed to address gaps, such as those related to participation in trials, completion of trials, and the overall research experience. Rigorous attention to these issues at project inception can inform trial design and conduct by matching research approaches to the context in which trials are to be conducted. Conducting behavioral and social sciences research concurrent with vaccine clinical research is important because it can help identify potential barriers to trial implementation, as well as ultimate acceptance and dissemination of trial results. We therefore propose a conceptual framework for behavioral and social science in HIV vaccine clinical research and use examples from the behavioral and social science literature to demonstrate how the model can facilitate identification of significant areas meriting additional exploration. Standardized use of the conceptual framework could improve HIV vaccine clinical research efficiency and relevance. Published by Elsevier Ltd.
NASA Astrophysics Data System (ADS)
Hahm, T. S.
2010-06-01
The 12th International Workshop on H-mode Physics and Transport Barriers was held at the Princeton Plasma Physics Laboratory, Princeton, New Jersey, USA between September 30 and October 2, 2009. This meeting was the continuation of a series of previous meetings which was initiated in 1987 and has been held bi-annually since then. Following the recent tradition at the last few meetings, the program was sub- divided into six sessions. At each session, an overview talk was presented, followed by two or three shorter oral presentations which supplemented the coverage of important issues. These talks were followed by discussion periods and poster sessions of contributed papers. The sessions were: Physics of Transition to/from Enhanced Confinement Regimes, Pedestal and Edge Localized Mode Dynamics, Plasma Rotation and Momentum Transport, Role of 3D Physics in Transport Barriers, Transport Barriers: Theory and Simulations and High Priority ITER Issues on Transport Barriers. The diversity of the 90 registered participants was remarkable, with 22 different nationalities. US participants were in the majority (36), followed by Japan (14), South Korea (7), and China (6). This special issue of Nuclear Fusion consists of a cluster of 18 accepted papers from submitted manuscripts based on overview talks and poster presentations. The paper selection procedure followed the guidelines of Nuclear Fusion which are essentially the same as for regular articles with an additional requirement on timeliness of submission, review and revision. One overview paper and five contributed papers report on the H-mode pedestal related results which reflect the importance of this issue concerning the successful operation of ITER. Four papers address the rotation and momentum transport which play a crucial role in transport barrier physics. The transport barrier transition condition is the main focus of other four papers. Finally, four additional papers are devoted to the behaviour and control of Edge Localized Modes. The selection of topics and overview speakers and the scientific programme were carried out by the International Advisory Committee, consisting of: R. Groebner (GA, USA), T.S. Hahm (PPPL, USA--Chair), A. Hubbard (MIT, USA), K. Ida (NIFS, Japan), S. Lebedev (Ioffe Institute, Russia), N. Oyama (JAEA, Japan), G. Saibene (F4E, EU) and W. Suttrop (IPP, Germany). Their work, advice, and participation contributed to the success of the meeting. Finally, I would like to express deep gratitude to J. Jones and B. Sarfaty who took care of numerous issues relating to the organization of the meeting, and to J.K. Park and several graduate students of the Princeton University Plasma Physics Program for helping with the transportation of participants.
NASA Astrophysics Data System (ADS)
Dinsmore, Daniel L.; Zoellner, Brian P.; Parkinson, Meghan M.; Rossi, Anthony M.; Monk, Mary J.; Vinnachi, Jenelle
2017-05-01
View change about socio-scientific issues has been well studied in the literature, but the change in the complexity of those views has not. In the current study, the change in the complexity of views about a specific scientific topic (i.e. genetically modified organisms; GMOs) and use of evidence in explaining those views was examined in relation to individual factors and type of text (informational, persuasive, or narrative). Undergraduate students completed measures of their prior views about GMOs their epistemic beliefs about the nature of science, and activities related to food consumption. Participants then read either an informational, persuasive, or narrative passage about GMOs and again answered a question related to their views about GMOs. Participants who read the persuasive passage decreased in the complexity of their views, while those who read the narrative and expository passage increased in the complexity of their views. Additionally, while cultural activities related to the complexity of individuals' views during the pretest, these significant differences were not evident at posttest after the text intervention. These findings can be used to help scientists and teachers better understand how to communicate information critical to understanding complex science and environmental issues to the public and their students.
Motives as predictors of the public's attitudes toward solid waste issues
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ebreo, A.; Vining, J.
2000-02-01
Surveys focusing on solid-waste-related issues, conducted over a period of several years, provided data from independent samples of residents of a Midwestern, USA, community. The collection of these data yielded useful information about the relationship between residents' recycling motives and their attitudes toward solid waste management in light of several changes in the solid waste infrastructure of the community over that time. The initial survey assessed baseline beliefs and attitudes, while later surveys were conducted after the implementation of a community educational program and a curbside recycling program. The findings indicated that for recyclers and nonrecyclers, different motives predicted endorsementmore » of solid waste programs and policies. Although a similar percentage of recyclers and nonrecyclers were in support of various proposed programs and policies, concern for the environment was found to be positively related to nonrecyclers' support of proposed programs, particularly before these programs were implemented. Prior to program implementation, motives other than environmental altruism were found to be related to recyclers' support of the programs. Additional findings support the idea that educational programs and increased accessibility to recycling opportunities affect the relationship between people's attitudes toward solid waste management and their recycling motives.« less
Verrinder, Joy M; Ostini, Remo; Phillips, Clive J C
2016-01-01
Moral judgment in relation to animal ethics issues has rarely been investigated. Among the research that has been conducted, studies of veterinary students have shown greater use of reasoning based on universal principles for animal than human ethics issues. This study aimed to identify if this was unique to students of veterinary and other animal-related professions. The moral reasoning of first year students of veterinary medicine, veterinary technology, and production animal science was compared with that of students in non-animal related disciplines of human medicine and arts. All students (n = 531) completed a moral reasoning test, the VetDIT, with animal and human scenarios. When compared with reasoning on human ethics issues, the combined group of students evaluating animal ethics issues showed higher levels of Universal Principles reasoning, lower levels of Personal Interest reasoning and similar levels of Maintaining Norms reasoning. Arts students showed more personal interest reasoning than students in most animal-related programs on both animal and human ethics issues, and less norms-based reasoning on animal ethics issues. Medical students showed more norms-based reasoning on animal ethics issues than all of the animal-related groups. There were no differences in principled reasoning on animal ethics issues between program groups. This has implications for animal-related professions and education programs showing that students' preference for principled reasoning on animal ethics issues is not unique to animal-related disciplines, and highlighting the need to develop student (and professional) capacity to apply principled reasoning to address ethics issues in animal industries to reduce the risk of moral distress.
Verrinder, Joy M.; Ostini, Remo; Phillips, Clive J. C.
2016-01-01
Moral judgment in relation to animal ethics issues has rarely been investigated. Among the research that has been conducted, studies of veterinary students have shown greater use of reasoning based on universal principles for animal than human ethics issues. This study aimed to identify if this was unique to students of veterinary and other animal-related professions. The moral reasoning of first year students of veterinary medicine, veterinary technology, and production animal science was compared with that of students in non-animal related disciplines of human medicine and arts. All students (n = 531) completed a moral reasoning test, the VetDIT, with animal and human scenarios. When compared with reasoning on human ethics issues, the combined group of students evaluating animal ethics issues showed higher levels of Universal Principles reasoning, lower levels of Personal Interest reasoning and similar levels of Maintaining Norms reasoning. Arts students showed more personal interest reasoning than students in most animal-related programs on both animal and human ethics issues, and less norms-based reasoning on animal ethics issues. Medical students showed more norms-based reasoning on animal ethics issues than all of the animal-related groups. There were no differences in principled reasoning on animal ethics issues between program groups. This has implications for animal-related professions and education programs showing that students’ preference for principled reasoning on animal ethics issues is not unique to animal-related disciplines, and highlighting the need to develop student (and professional) capacity to apply principled reasoning to address ethics issues in animal industries to reduce the risk of moral distress. PMID:26934582
45 CFR 1386.93 - Issues at hearing.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 45 Public Welfare 4 2010-10-01 2010-10-01 false Issues at hearing. 1386.93 Section 1386.93 Public... Preliminary Matters-Notice and Parties § 1386.93 Issues at hearing. (a) Prior to a hearing, the Assistant Secretary may notify the State in writing of additional issues which will be considered at the hearing. That...
NATIONAL GEOSCIENCE DATA REPOSITORY SYSTEM PHASE III: IMPLEMENTATION AND OPERATION ON THE REPOSITORY
DOE Office of Scientific and Technical Information (OSTI.GOV)
Marcus Milling
2001-10-01
The NGDRS has attained 72% of its targeted goal for cores and cuttings transfers, with over 12 million linear feet of cores and cuttings, in addition to large numbers of paleontological samples and are now available for public use. Additionally, large-scale transfers of seismic data have been evaluated, but based on the recommendation of the NGDRS steering committee, cores have been given priority because of the vast scale of the seismic data problem relative to the available funding. The rapidly changing industry conditions have required that the primary core and cuttings preservation strategy evolve as well. Additionally, the NGDRS clearinghousemore » is evaluating the viability of transferring seismic data covering the western shelf of the Florida Gulf Coast. AGI remained actively involved in assisting the National Research Council with background materials and presentations for their panel convened to study the data preservation issue. A final report of the panel is expected in early 2002. GeoTrek has been ported to Linux and MySQL, ensuring a purely open-source version of the software. This effort is key in ensuring long-term viability of the software so that is can continue basic operation regardless of specific funding levels. Work has commenced on a major revision of GeoTrek, using the open-source MapServer project and its related MapScript language. This effort will address a number of key technology issues that appear to be rising for 2002, including the discontinuation of the use of Java in future Microsoft operating systems. Discussions have been held regarding establishing potential new public data repositories, with hope for final determination in 2002.« less
40 CFR 300.220 - Related Title III issues.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Related Title III issues. 300.220 Section 300.220 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... PLAN Planning and Preparedness § 300.220 Related Title III issues. Other related Title III requirements...
Diagnostic tools in Rhinology EAACI position paper
2011-01-01
This EAACI Task Force document aims at providing the readers with a comprehensive and complete overview of the currently available tools for diagnosis of nasal and sino-nasal disease. We have tried to logically order the different important issues related to history taking, clinical examination and additional investigative tools for evaluation of the severity of sinonasal disease into a consensus document. A panel of European experts in the field of Rhinology has contributed to this consensus document on Diagnostic Tools in Rhinology. PMID:22410181
2016-08-15
we obtained an understanding of the system of quality control for the audit organization. In addition, we tested auditors ’ compliance with the...a threat to independence is initially identified after the auditor’s report is issued, the auditor should evaluate the threat’s impact on the audit...General GAS 3.02 states that in all matters relating to audit work, the audit organization and the individual auditor , whether Government or public, must
15N Fractionation in Star-Forming Regions and Solar System Objects
NASA Technical Reports Server (NTRS)
Wirstrom, Eva; Milam, Stefanie; Adande, GIlles; Charnley, Steven; Cordiner, Martin
2015-01-01
A central issue for understanding the formation and evolution of matter in the early Solar System is the relationship between the chemical composition of star-forming interstellar clouds and that of primitive Solar System materials. The pristinemolecular content of comets, interplanetary dust particles and carbonaceous chondrites show significant bulk nitrogen isotopic fractionation relative to the solar value, 14N15N 440. In addition, high spatial resolution measurements in primitive materials locally show even more extreme enhancements of 14N15N 100.
Study Designs and Statistical Analyses for Biomarker Research
Gosho, Masahiko; Nagashima, Kengo; Sato, Yasunori
2012-01-01
Biomarkers are becoming increasingly important for streamlining drug discovery and development. In addition, biomarkers are widely expected to be used as a tool for disease diagnosis, personalized medication, and surrogate endpoints in clinical research. In this paper, we highlight several important aspects related to study design and statistical analysis for clinical research incorporating biomarkers. We describe the typical and current study designs for exploring, detecting, and utilizing biomarkers. Furthermore, we introduce statistical issues such as confounding and multiplicity for statistical tests in biomarker research. PMID:23012528
NASA Astrophysics Data System (ADS)
Helsen, Jef A.; Jürgen Breme, H.
1998-10-01
Biomaterials is a field that continues to attract a significant amount of attention from researchers, industry, educationalists and regulators. This book is the first to provide readers with an understanding of fundamental theory relating to the use of metals in biomedical applications in addition to comprehensively covering applied aspects encompassing practical and technical advantages and disadvantages. Topics highlighted in the book include guidelines for selecting materials; shape memory alloys; degradation and surface modification; adhesion to ceramics and polymers; biocompartibility and tissue-implant interactions; and European and North American regulatory issues.
Exploring work-related issues on corporate sustainability.
Brunoro, C M; Bolis, I; Sznelwar, L I
2015-01-01
In a research project about work-related issues and corporate sustainability conducted in Brazil, the goal was to better understand how work-related issues were addressed in the corporate context. Particularly, there are some specific initiatives that serve as guides to organizational decisions, which make their performance indicators for the context of corporate sustainability. 1) To explore the presence of work-related issues and their origins in corporate sustainability approach, analyzing a) corporate disclosures; b) sustainability guidelines that are identified as relevant in corporate disclosures; c) documents that are related to sustainable development and also identified as key-documents for these guidelines and initiatives. 2) To present the activity-centered ergonomics and psychodynamics of work contributions to work-related issues in a corporate sustainability approach. An exploratory study based on multiple sources of evidence that were performed from 2012 to 2013, including interviews with companies that engaged in corporate sustainability and document analysis using the content analysis approach. Work-related issues have been presented since the earliest sustainable development documents. It is feasible to construct an empirical framework for work-related issues and corporate sustainability approaches. 1) Although some authors argue that corporate sustainability has its roots based only on the environmental dimension, there is strong empirical evidence showing that social dimension aspects such as work-related issues have been present since the beginning. 2) Some indicators should be redesigned to more precisely translate the reality of some workplaces, particularly those indicators related to organizational design and mental health.
Maloney, Kelly O.; Schmid, Matthias; Weller, Donald E.
2012-01-01
Issues with ecological data (e.g. non-normality of errors, nonlinear relationships and autocorrelation of variables) and modelling (e.g. overfitting, variable selection and prediction) complicate regression analyses in ecology. Flexible models, such as generalized additive models (GAMs), can address data issues, and machine learning techniques (e.g. gradient boosting) can help resolve modelling issues. Gradient boosted GAMs do both. Here, we illustrate the advantages of this technique using data on benthic macroinvertebrates and fish from 1573 small streams in Maryland, USA.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 1 2010-10-01 2010-10-01 false What additional documentation may the Secretary require to resolve eligibility or payment issues? 130.24 Section 130.24 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPASSIONATE PAYMENTS RICKY RAY HEMOPHILIA RELIEF FUND...
Kunaparaju, Sindhura; Hidalgo, Michael Sposito; Bennett, David S; Sedky, Karim
2018-06-01
Due to lack of experience, third-year medical students (MS3) may be vulnerable to boundary violations. Investigators aimed to increase awareness regarding boundary issues among MS3s and assess the effect of using videotaped scenarios and case-based discussion on medical students' comfort in managing boundary issues. A nine-question pre-course survey was administered to MS3s enrolled at Cooper Medical School of Rowan University that asked students to rate their comfort in managing various boundary challenges. MS3s then viewed seven pre-recorded boundary-related cases followed by a 10-15-min discussion after each case. A post-course survey reassessed comfort in managing boundary challenges using the same nine questions, with three additional questions assessing satisfaction with the course. Change in pre- and post-course scores were analyzed using paired t tests and effect sizes. Internal consistency was assessed using Cronbach's alpha. There was a significant difference between pre- and post-course total scores as well as seven of the nine individual scores. Effect sizes were large (d > .08). These findings indicate that students became more comfortable managing boundary issues following the course. In addition, satisfaction ratings were high indicating the course was perceived favorably. Medical students perceived the course to be beneficial and reported that it increased their awareness of boundary issues. A boundary course at the beginning of the psychiatry clerkship can improve MS3s' comfort in managing boundary challenges. With increased comfort in managing boundary, students can better focus on other aspects of their psychiatry education and on building therapeutic alliances with their patients.
DOE Office of Scientific and Technical Information (OSTI.GOV)
NONE
The Gulf of Mexico and Louisiana continue to be areas with a high level of facility removal, and the pace of removal is projected to increase. Regulations were promulgated for the Gulf of Mexico and Louisiana requiring that abandoned sites be cleared of debris that could interfere with fishing and shrimping activities. The site clearance regulations also required verification that the sites were clear. Additionally, government programs were established to compensate fishermen for losses associated with snagging their equipment on oil and gas related objects that remained on the water bottoms in areas other than active producing sites and sitesmore » that had been verified as clear of obstructions and snags. The oil and gas industry funds the compensation programs. This paper reviews the regulations and evolving operating practices in the Gulf of Mexico and Louisiana where site clearance and fisherman`s gear compensation regulations have been in place for a number of years. Although regulations and guidelines may be in place elsewhere in the world, this paper focuses on the Gulf of Mexico and Louisiana. Workshop participants are encouraged to bring up international issues during the course of the workshop. Additionally, this paper raises questions and focuses on issues that are of concern to the various Gulf of Mexico and Louisiana water surface and water bottom stakeholders. This paper does not have answers to the questions or issues. During the workshop participants will debate the questions and issues in an attempt to develop consensus opinions and/or make suggestions that can be provided to the appropriate organizations, both private and government, for possible future research or policy adjustments. Site clearance and facility removal are different activities. Facility removal deals with removal of the structures used to produce oil and gas including platforms, wells, casing, piles, pipelines, well protection structures, etc.« less
Educational Financing in Developing Countries: Research Findings and Contemporary Issues.
ERIC Educational Resources Information Center
Schiefelbein, Ernesto
This study focuses on contemporary issues of educational financing in developing countries and on available research findings as these relate, or can be related, to these issues. The first two chapters are analytical, examining common educational finance issues and testing the conventional wisdom of certain usual proposals. Chapter 1, "Issues in…
Terry, Daniel; Lê, Quynh; Nguyen, Uyen; Hoang, Ha
2015-08-12
The objective of the study was to investigate the types of workplace health and safety issues rural community nurses encounter and the impact these issues have on providing care to rural consumers. The study undertook a narrative inquiry underpinned by a phenomenological approach. Community nursing staff who worked exclusively in rural areas and employed in a permanent capacity were contacted among 13 of the 16 consenting healthcare services. All community nurses who expressed a desire to participate were interviewed. Data were collected using semistructured interviews with 15 community nurses in rural and remote communities. Thematic analysis was used to analyse interview data. The role, function and structures of community nursing services varied greatly from site to site and were developed and centred on meeting the needs of individual communities. In addition, a number of workplace health and safety challenges were identified and were centred on the geographical, physical and organisational environment that community nurses work across. The workplace health and safety challenges within these environments included driving large distances between client's homes and their office which lead to working in isolation for long periods and without adequate communication. In addition, other issues included encountering, managing and developing strategies to deal with poor client and carer behaviour; working within and negotiating working environments such as the poor condition of patient homes and clients smoking; navigating animals in the workplace; vertical and horizontal violence; and issues around workload, burnout and work-related stress. Many nurses achieved good outcomes to meet the needs of rural community health consumers. Managers were vital to ensure that service objectives were met. Despite the positive outcomes, many processes were considered unsafe by community nurses. It was identified that greater training and capacity building are required to meet the needs among all staff. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Terry, Daniel; Lê, Quynh; Nguyen, Uyen; Hoang, Ha
2015-01-01
Objectives The objective of the study was to investigate the types of workplace health and safety issues rural community nurses encounter and the impact these issues have on providing care to rural consumers. Methods The study undertook a narrative inquiry underpinned by a phenomenological approach. Community nursing staff who worked exclusively in rural areas and employed in a permanent capacity were contacted among 13 of the 16 consenting healthcare services. All community nurses who expressed a desire to participate were interviewed. Data were collected using semistructured interviews with 15 community nurses in rural and remote communities. Thematic analysis was used to analyse interview data. Results The role, function and structures of community nursing services varied greatly from site to site and were developed and centred on meeting the needs of individual communities. In addition, a number of workplace health and safety challenges were identified and were centred on the geographical, physical and organisational environment that community nurses work across. The workplace health and safety challenges within these environments included driving large distances between client’s homes and their office which lead to working in isolation for long periods and without adequate communication. In addition, other issues included encountering, managing and developing strategies to deal with poor client and carer behaviour; working within and negotiating working environments such as the poor condition of patient homes and clients smoking; navigating animals in the workplace; vertical and horizontal violence; and issues around workload, burnout and work-related stress. Conclusions Many nurses achieved good outcomes to meet the needs of rural community health consumers. Managers were vital to ensure that service objectives were met. Despite the positive outcomes, many processes were considered unsafe by community nurses. It was identified that greater training and capacity building are required to meet the needs among all staff. PMID:26270947
Strategies for teaching object-oriented concepts with Java
NASA Astrophysics Data System (ADS)
Sicilia, Miguel-Ángel
2006-03-01
A considerable amount of experiences in teaching object-oriented concepts using the Java language have been reported to date, some of which describe language pitfalls and concrete learning difficulties. In this paper, a number of additional issues that have been experienced as difficult for students to master, along with approaches intended to overcome them, are addressed. Concretely, practical issues regarding associations, interfaces, genericity and exceptions are described. These issues suggest that more emphasis is required on presenting Java programs as derivations of conceptual models, in order to guarantee that a thorough design of the object structure actually precedes implementation issues. In addition, common student misunderstandings about the uses of interfaces and exceptions point to the necessity of introducing both specific design philosophies and also a clear distinction between design-for-reuse and more specific implementation issues.
Evaluation of advanced multiplex short tandem repeat systems in pairwise kinship analysis.
Tamura, Tomonori; Osawa, Motoki; Ochiai, Eriko; Suzuki, Takanori; Nakamura, Takashi
2015-09-01
The AmpFLSTR Identifiler Kit, comprising 15 autosomal short tandem repeat (STR) loci, is commonly employed in forensic practice for calculating match probabilities and parentage testing. The conventional system exhibits insufficient estimation for kinship analysis such as sibship testing because of shortness of examined loci. This study evaluated the power of the PowerPlex Fusion System, GlobalFiler Kit, and PowerPlex 21 System, which comprise more than 20 autosomal STR loci, to estimate pairwise blood relatedness (i.e., parent-child, full siblings, second-degree relatives, and first cousins). The genotypes of all 24 STR loci in 10,000 putative pedigrees were constructed by simulation. The likelihood ratio for each locus was calculated from joint probabilities for relatives and non-relatives. The combined likelihood ratio was calculated according to the product rule. The addition of STR loci improved separation between relatives and non-relatives. However, these systems were less effectively extended to the inference for first cousins. In conclusion, these advanced systems will be useful in forensic personal identification, especially in the evaluation of full siblings and second-degree relatives. Moreover, the additional loci may give rise to two major issues of more frequent mutational events and several pairs of linked loci on the same chromosome. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
45 CFR 213.14 - Issues at hearing.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 45 Public Welfare 2 2010-10-01 2010-10-01 false Issues at hearing. 213.14 Section 213.14 Public...-Notice and Parties § 213.14 Issues at hearing. (a) The Administrator may, prior to a hearing under § 201.6 (a) or (b) of this chapter, notify the State in writing of additional issues which will be...
19 CFR 181.98 - Situations in which no NAFTA advance ruling may be issued.
Code of Federal Regulations, 2010 CFR
2010-04-01
... subpart. No advance ruling letter will be issued in regard to a completed transaction. (b) Pending matters... issue the requested advance ruling. In addition, no NAFTA advance ruling letter will be issued with... other court will not preclude the issuance of an advance ruling letter, provided neither Customs nor any...
Praestegaard, Jeanette; Gard, Gunvor
2013-02-01
An important aspect of physiotherapy professional autonomy is the ethical code of the profession, both collectively and for the individual member of the profession. The aim of this study is to explore and add additional insight into the nature and scope of ethical issues as they are understood and experienced by Danish physiotherapists in outpatient, private practice. A qualitative approach was chosen and semi-structured interviews with 21 physiotherapists were carried out twice and analyzed, using a phenomenological hermeneutic framework. One main theme emerged: The ideal of being beneficent toward the patient. Here, the ethical issues uncovered in the interviews were embedded in three code-groups: 1) ethical issues related to equality; 2) feeling obligated to do one's best; and 3) transgression of boundaries. In an ethical perspective, physiotherapy in private practice is on a trajectory toward increased professionalism. Physiotherapists in private practice have many reflections on ethics and these reflections are primarily based on individual common sense arguments and on deontological understandings. As physiotherapy by condition is characterized by asymmetrical power encounters where the parties are in close physical and emotional contact, practiced physiotherapy has many ethical issues embedded. Some physiotherapists meet these issues in a professional manner, but others meet them in unconscious or unprofessional ways. An explicit ethical consciousness among Danish physiotherapists in private practice seems to be needed. A debate of how to understand and respect the individual physiotherapist's moral versus the ethics of the profession needs to be addressed.
In and across bureaucracy: structural and administrative issues for the tobacco endgame.
Isett, Kimberley R
2013-05-01
This article assesses the structural choices for the proposed tobacco endgame strategies. I focus on the issues associated with particular structural choices for the location of the implementation. Specifically, I discuss issues related to implementation of the endgame within a specific single agency, and issues related to a more widespread, broad implementation involving several agencies. Where appropriate, I provide examples of how the dynamics discussed would apply to particular endgame strategies. Issues related to design, administration, authority and finances are raised.
In and across bureaucracy: structural and administrative issues for the tobacco endgame
Isett, Kimberley R
2013-01-01
This article assesses the structural choices for the proposed tobacco endgame strategies. I focus on the issues associated with particular structural choices for the location of the implementation. Specifically, I discuss issues related to implementation of the endgame within a specific single agency, and issues related to a more widespread, broad implementation involving several agencies. Where appropriate, I provide examples of how the dynamics discussed would apply to particular endgame strategies. Issues related to design, administration, authority and finances are raised. PMID:23591514
Nishijima, Daniel K.; Dinh, Tu; May, Larissa; Yadav, Kabir; Gaddis, Gary M.; Cone, David C.
2014-01-01
Purpose Since 2000, Academic Emergency Medicine (AEM), the journal of the Society for Academic Emergency Medicine, has presented a one-day consensus conference to generate a research agenda for advancement of a scientific topic. One of the 12 annual issues of AEM is reserved for the proceedings of these conferences. The purpose of this study was to measure academic productivity of these conferences by evaluating subsequent federal research funding received by authors of conference manuscripts and calculating citation counts of conference papers. Method This was a cross-sectional study conducted during August and September 2012. NIH RePORTER was searched to identify subsequent federal funding obtained by authors of the consensus conference issues from 2000 to 2010. Funded projects were coded as related or unrelated to conference topic. Citation counts for all conference manuscripts were quantified using Scopus and Google Scholar. Simple descriptive statistics were reported. Results 852 individual authors contributed to 280 papers published in the 11 consensus conference issues. 137 authors (16%) obtained funding for 318 projects. A median of 22 topic-related projects per conference (range 10–97 projects) accounted for a median of $20,488,331 per conference (range $7,779,512–122,918,205). The average (±SD) number of citations per paper was 15.7 ±20.5 in Scopus and 23.7 ±32.6 in Google Scholar. Conclusions The authors of consensus conference manuscripts obtained significant federal grant support for follow-up research related to conference themes. In addition, the manuscripts generated by these conferences were frequently cited. Conferences devoted to research agenda development appear to be an academically worthwhile endeavor. PMID:24280853
Relationships between school start time, sleep duration, and adolescent behaviors.
Wahlstrom, Kyla L; Berger, Aaron T; Widome, Rachel
2017-06-01
The objectives were 2-fold: (1) to examine how high school start times relate to adolescent sleep duration, and (2) to test associations between sleep duration and mental health- and substance use-related issues and behaviors in teens. This study examines selected questions from survey data collected between 2010 and 2013 high school students. Respondents included more than 9000 students in grades 9 to 12 in 8 high schools in 5 school districts across the United States. The survey instrument is the 97-item Teen Sleep Habits Survey. Logistic regression models were used to calculate adjusted odds ratios and 95% confidence intervals. Because of clustering within schools and the use of repeated measures, generalized estimating equations were used to account for variance inflation. Greater sleep duration was associated with fewer reports of various mental health- and substance use-related issues and behaviors (all P values <.01). For instance, for each additional hour of sleep reported, there was a 28% reduction in the adjusted odds of a participant reporting that he or she felt "unhappy, sad, or depressed." Later wake-up times were associated with a reduction in risk for some, but not all factors. Later start times were significantly associated with greater sleep duration. Given that later start times allow for greater sleep duration and that adequate sleep duration is associated with more favorable mental health- and substance use-related issues and behaviors, it is important that school districts prioritize exploring and implementing policies, such as delayed start times, that may increase the amount of sleep of adolescent students, which is needed for their optimal development. Copyright © 2017 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
OECD/NEA Ongoing activities related to the nuclear fuel cycle
DOE Office of Scientific and Technical Information (OSTI.GOV)
Cornet, S.M.; McCarthy, K.; Chauvin, N.
2013-07-01
As part of its role in encouraging international collaboration, the OECD Nuclear Energy Agency is coordinating a series of projects related to the Nuclear Fuel Cycle. The Nuclear Science Committee (NSC) Working Party on Scientific Issues of the Nuclear Fuel Cycle (WPFC) comprises five different expert groups covering all aspects of the fuel cycle from front to back-end. Activities related to fuels, materials, physics, separation chemistry, and fuel cycles scenarios are being undertaken. By publishing state-of-the-art reports and organizing workshops, the groups are able to disseminate recent research advancements to the international community. Current activities mainly focus on advanced nuclearmore » systems, and experts are working on analyzing results and establishing challenges associated to the adoption of new materials and fuels. By comparing different codes, the Expert Group on Advanced Fuel Cycle Scenarios is aiming at gaining further understanding of the scientific issues and specific national needs associated with the implementation of advanced fuel cycles. At the back end of the fuel cycle, separation technologies (aqueous and pyrochemical processing) are being assessed. Current and future activities comprise studies on minor actinides separation and post Fukushima studies. Regular workshops are also organized to discuss recent developments on Partitioning and Transmutation. In addition, the Nuclear Development Committee (NDC) focuses on the analysis of the economics of nuclear power across the fuel cycle in the context of changes of electricity markets, social acceptance and technological advances and assesses the availability of the nuclear fuel and infrastructure required for the deployment of existing and future nuclear power. The Expert Group on the Economics of the Back End of the Nuclear Fuel Cycle (EBENFC), in particular, is looking at assessing economic and financial issues related to the long term management of spent nuclear fuel. (authors)« less
An examination of stress and burnout in certified athletic trainers at division I-a universities.
Hendrix, A E; Acevedo, E O; Hebert, E
2000-04-01
A growing body of knowledge indicates that too much stress can negatively influence psychological and physical health. A model proposed by Smith to explore personal and situational variables, stress appraisal, and burnout has led to significant understanding of burnout of individuals working in service professions. We examined the relationship of hardiness, social support, and work-related issues relevant to athletic trainers to perceived stress and the relationship of perceived stress to burnout. Correlational analyses were performed to examine the relationships predicted by Smith's model. In addition, we conducted stepwise multiple regression analyses to assess the relative contributions of the personal and situational variables to perceived stress and to examine the relative impact of perceived stress on 3 burnout factors (emotional exhaustion, personal accomplishment, and depersonalization). One hundred eighteen certified athletic trainers working in National Collegiate Athletic Association Division I-A intercollegiate settings that maintain a football program. We assessed personal and situational variables using the Hardiness Test, the Social Support Questionnaire, and the Athletic Training Issues Survey, adapted for this study. The Perceived Stress Scale was used to assess stress appraisal, and the Maslach Burnout Inventory was used to assess 3 dimensions of burnout. Our results were in support of Smith's theoretical model of stress and burnout. Athletic trainers who scored lower on hardiness and social support and higher on athletic training issues tended to have higher levels of perceived stress. Furthermore, higher perceived stress scores were related to higher emotional exhaustion and depersonalization and lower levels of personal accomplishment. Our findings examining burnout in Division I athletic trainers were similar to those of other studies investigating coaches and coach-teachers and in support of Smith's theoretical model of stress and burnout.
Three-dimensional rendering in medicine: some common misconceptions
NASA Astrophysics Data System (ADS)
Udupa, Jayaram K.
2001-05-01
As seen in the medical imaging literature and in the poster presentations at the annual conference of the Radiological Society of North America during the past 10 years, several mis conceptions are held relating to 3D rendering of medical images. The purpose of this presentation is to illustrate and clarify these with medical examples. Most of the misconceptions have to do with a mix up of the issues related to the common visualization techniques, viz., surface rendering (SR) and volume rendering (VR), and methods of image segmentation. In our survey, we came across the following most commonly held conceptions which we believe (and shall demonstrate) are not correct: (1) SR equated to thresholding. (2) VR considered not requiring segmentation. (3) VR considered to achieve higher resolution than SR. (4) SR/VR considered to require specialized hardware to achieve adequate speed. We shall briefly define and establish some fundamental terms to obviate any potential for terminology-related misconceptions. Subsequently, we shall sort out these issues and illustrate with examples as to why the above conceptions are incorrect. There are many SR methods that use segmentations that are far superior to thresholding. All VR techniques (except the straightforward MIP) require some form of fuzzy object specification, that is, fuzzy segmentation. The details seen in renditions depend fundamentally on, in addition to the rendering method, segmentation techniques also. There are fast-software-based rendering methods that give a performance on PCs similar to or exceeding that of expensive hardware systems. Most of the difficulties encountered in visualization (and also in image processing and analysis) stem from the difficulties in segmentation. It is important to identify these and separate them from the issues related purely to 3D rendering.
Porter, Laura S; Fish, Laura; Steinhauser, Karen
2018-04-25
Couple-based communication interventions have beneficial effects for patients with cancer and their partners. However, few studies have targeted patients with advanced stages of disease and little is known about how best to assist couples in discussing issues related to life-limiting illness. The purpose of the present study was to identify themes couples addressed during a couple communication skills intervention, and the frequency with which they discussed issues related to end-of-life. Content analyses were conducted on recordings of 72 sessions from 12 couples facing advanced gastrointestinal (GI) cancer. Coding was based six themes identified a priori from the framework for understanding what patients and family value at end of life. The percent of couples addressing each theme was calculated to gauge level of importance and acceptability of these topics. The majority of couples addressed topics previously identified as salient at end-of-life, including clear decision making, affirmation of the whole person, pain and symptom management, contributing to others, and preparation for death. In addition, novel aspects to these themes emerged in the context of couples' conversations, illustrating the importance of the couple relationship in adjusting to life with a life-limiting illness and anticipating the transition to end-of-life. Findings suggest that couples likely would be receptive to an intervention that combines training in communication skills with guidance in focusing on issues related to life completion to assist with transitions at end of life. Such interventions might enhance both individuals' abilities to cope with illness-related symptoms and demands, enjoy the time they have together, and derive meaning from the experience. Copyright © 2018. Published by Elsevier Inc.
Shoulder biomechanics and the success of translational research.
Cutti, Andrea Giovanni; Chadwick, Edward K
2014-03-01
In 2009, the International Shoulder Group (ISG) had the opportunity to propose to the readers of Medical and Biological Engineering and Computing a Special Issue on shoulder biomechanics. At that time, we pointed out that the field was evolving to include more applied research. After 4 years, we can confirm that impression: 10 out of 12 papers included in this second Special Issue deal with clinical related questions, through theoretical and experimental methodologies. This demonstrates that the translational research at the base of ISG foundation in 1989 is effective. We think that the papers of this issue will have an impact on clinics in general and on the treatment of work-related injuries and diseases in particular. Based on the statistics of the Italian Workers' Compensation Authority (INAIL), injuries at the shoulder are first in terms of average duration of "temporary total disability to work". Moreover, occupational diseases at the shoulder in the industrial and services sector represented 16 % of all occupational diseases in 2012, i.e., 46 % of those related to the upper limb. These data stress the need for specific interventions, with the contribution of both researchers and policy makers. Starting from the papers included here, we would encourage additional efforts on: (1) quantitative analysis of shoulder loading during tasks associated with musculoskeletal injuries, and ways to reduce that loading, (2) simple and effective tools to improve the diagnosis and outcome assessment of motion-related shoulder diseases, and (3) the development of rehabilitation treatments focused on occupational tasks, taking advantage of state-of-the-art biofeedback technologies, and exploiting the power of biomechanical models for muscle force prediction.
A systematic review of ethical issues in vaccine studies involving pregnant women.
Beeler, Jennifer A; Lambach, Philipp; Fulton, T Roice; Narayanan, Divya; Ortiz, Justin R; Omer, Saad B
2016-08-02
Immunization during pregnancy can provide protection for mother and child. However, there have been only a limited number of studies documenting the efficacy and safety of this strategy. To determine the extent and nature of subject matter related to ethics in maternal immunization by systematically documenting the spectrum of ethical issues in vaccine studies involving pregnant women. We conducted a systematic literature review of published works pertaining to vaccine and therapeutic studies involving pregnant women through searches of PubMed, EMBASE, Web of Science, the Cochrane Database, and ClinicalTrials.gov. We selected literature meeting the inclusion criteria published between 1988 and June 2014. We systematically abstracted subject matter pertaining to ethical issues in immunization studies during pregnancy. Immunization-specific ethical issues were matched and grouped into major categories and subcategories. Seventy-seven published articles met the inclusion criteria. Published articles reported findings on data that had been collected in 26 countries, the majority of which were classified as high-income or upper-middle-income nations according to World Bank criteria. Review of these publications produced 60 immunization-specific ethical issues, grouped into six major categories. Notably, many studies demonstrated limited acknowledgment of key ethical issues including the rights and welfare of participants. Additionally, there was no discussion pertaining to the ethics of program implementation, including integration of maternal immunization programs into existing routine immunization programs. This review of ethical issues in immunization studies of pregnant women can be used to help inform future vaccine trials in this important population. Consistent documentation of these ethical issues by investigators will facilitate a broader and more nuanced discussion of ethics in immunization of pregnant women - offering new and valuable insights for programs developed to prevent disease in newborn children in low- and middle-income countries.
Primary care health issues among men who have sex with men.
Gee, Royal
2006-04-01
The purpose of the article is to examine "appropriate" health care for men who have sex with men (MSM), which is not to suggest "special" health care. As a group, MSM are at increased risk for sexually transmitted infections, anal cancer, and mental health disorders. Focus areas in this article will address health issues that the primary care nurse practitioner (NP) may encounter in clinical practice: anal carcinoma, sexually transmitted diseases (STDs), high-risk sexual practices, depression, and substance abuse were topics chosen for inclusion in this article. These topics were among those highlighted in the Healthy People 2010 Companion Document for LGBT Health, which served to examine the healthcare disparities and lack of access to needed services related to sexual orientation. Extensive literature review of research articles, journals, clinical practice guidelines, books, and public health department Internet Web sites. There are unique health disparities that exist for MSM related to social, emotional, and mental health factors, in addition to physical issues such as STDs. There is an increasing need for primary care providers to be aware of these disparities, as well as the factors that influence these disparities, in order to provide multidimensional care and health counseling that is unique to NP practice. Both the primary care NP and the patient should be aware of the unique healthcare issues among MSM that should be incorporated into the patient's routine health maintenance program. As primary care providers, it is within the standards of practice for NPs to provide culturally competent care, along with health promotion and disease prevention for MSM.
ExplorOcean H2O SOS: Help Heal the Ocean-Student Operated Solutions: Operation Climate Change
NASA Astrophysics Data System (ADS)
Weiss, N.; Wood, J. H.
2016-12-01
The ExplorOcean H2O SOS: Help Heal the Ocean—Student Operated Solutions: Operation Climate Change, teaches middle and high school students about ocean threats related to climate change through hands-on activities and learning experiences in the field. During each session (in-class or after-school as a club), students build an understanding about how climate change impacts our oceans using resources provided by ExplorOcean (hands-on activities, presentations, multi-media). Through a student leadership model, students present lessons to each other, interweaving a deep learning of science, 21st century technology, communication skills, and leadership. After participating in learning experiences and activities related to 6 key climate change concepts: 1) Introduction to climate change, 2) Increased sea temperatures, 3) Ocean acidification, 4) Sea level rise, 5) Feedback mechanisms, and 6) Innovative solutions. H2O SOS- Operation Climate change participants select one focus issue and use it to design a multi-pronged campaign to increase awareness about this issue in their local community. The campaign includes social media, an interactive activity, and a visual component. All participating clubs that meet participation and action goals earn a field trip to ExplorOcean where they dive deeper into their selected issue through hands-on activities, real-world investigations, and interviews or presentations with experts. In addition to self-selected opportunities to showcase their focus issue, teams will participate in one of several key events identified by ExplorOcean, including ExplorOcean's annual World Oceans Day Expo.
Unresolved legal questions in cross-border health care in Europe: liability and data protection.
van der Molen, I N; Commers, M J
2013-11-01
Directive 2011/24/EU was designed to clarify the rights of EU citizens in evaluating, accessing and obtaining reimbursement for cross-border care. Based on three regional case studies, the authors attempted to assess the added value of the Directive in helping clarify issues in to two key areas that have been identified as barriers to cross-border care: liability and data protection. Qualitative case study employing secondary data sources including research of jurisprudence, that set up a Legal framework as a base to investigate liability and data protection in the context of cross-border projects. By means of three case studies that have tackled liability and data protection hurdles in cross-border care implementation, this article attempts to provide insight into legal certainty and uncertainty regarding cross-border care in Europe. The case studies reveal that the Directive has not resolved core uncertainties related to liability and data protection issues within cross-border health care. Some issues related to the practice of cross-border health care in Europe have been further clarified by the Directive and some direction has been given to possible solutions for issues connected to liability and data protection. Directive 2011/24/EU is clearly a transposition of existing regulations on data protection and ECJ case law, plus a set of additional, mostly, voluntary rules that might enhance regional border cooperation. Therefore, as shown in the case studies, a practical and case by case approach is still necessary in designing and providing cross-border care. © 2013 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
Makanjuola, Titilola; Taddese, Henock B.; Booth, Andrew
2014-01-01
Objective To systematically identify from qualitative data in the published literature the main barriers to adherence to isoniazid preventive therapy (IPT) for tuberculosis (TB) among people living with HIV/AIDS (PLWHA). Methods We searched ten data sources, including MEDLINE and EMBASE for articles published in peer-reviewed journals from inception through to December 2011 for evidence relevant to IPT for TB in relation to PLWHA. Studies were assessed for quality using the CASP critical appraisal tool for qualitative studies. Data extracted from studies were then analysed thematically using thematic synthesis. Results Eight studies, two of which were conducted within the same clinical trial, met the inclusion criteria. In addition to the influence of personal characteristics, five overarching themes were identified: Individual personal beliefs; HIV treatment and related issues; Socio-economic factors; Family and other social support factors, and Relationships with health providers. The review confirms current understanding of adherence to treatment as influenced by patients' understanding of, and beliefs related to treatment regimens. This is in-turn influenced by broader factors, namely: socio-economic factors such as poverty and lack of health facilities; the level of support available to patients from family and other networks and the stigma that emanates from these relationships; and relationships with health providers, which in-turn become a delicate issue given the sensitivity of dealing with two chronic diseases of significant morbidity and mortality toll. HIV treatment related issues also influence adherence to IPT, whereby challenges related to the acceptance, organisation and administration of these two long-term treatment regimens and stigma related to HIV/AIDS, are seen to be major factors. Conclusion Understanding this complex interplay of factors more clearly is essential for healthcare decision-makers to be able to achieve the level of adherence required to effectively mitigate the threat posed by co-infection with TB and HIV/AIDS in developing countries. PMID:24498298
Research issues in preparedness for mass casualty events, disaster, war, and terrorism.
Hinton Walker, Patricia; Garmon Bibb, Sandra C; Elberson, Karen L
2005-09-01
This article provides a perspective on the types of research questions that might be explored and strategies used in relation to disaster,terrorism, and mass casualty events. Research is addressed in the context of three areas of focus: issues related to the health care provider; issues affecting the patient, individual, family, and community; and issues related to the health care system.
Practical Considerations in Donation After Circulatory Determination of Death in Switzerland.
Dalle Ave, Anne L; Shaw, David M; Elger, Bernice
2017-09-01
Faced with similar issues of organ scarcity to its neighbors, Switzerland has developed donation after circulatory determination of death (DCDD) as a way to expand the organ pool since 1985. Here, we analyze the history, practical considerations, and ethical issues relating to the Swiss donation after circulatory death programs. In Switzerland, determination of death for DCDD requires a stand-off period of 10 minutes. This time between cardiac arrest and the declaration of death is mandated in the guidelines of the Swiss Academy of Medical Sciences. As in other DCDD programs, safeguards are put to avoid physicians denying lifesaving treatment to savable patients because of being influenced by receivers' interest. An additional recommendation could be made: Recipients should be transparently informed of the worse graft outcomes with DCDD programs and given the possibility to refuse such organs.
International Space Education Outreach: Taking Exploration to the Global Classroom
NASA Technical Reports Server (NTRS)
Dreschel, T. W.; Lichtenberger, L. A.; Chetirkin, P. V.; Garner, L. C.; Barfus, J. R.; Nazarenko, V. I.
2005-01-01
With the development of the International Space Station and the need for international collaboration for returning to the moon and developing a mission to Mars, NASA has embarked on developing international educational programs related to space exploration. In addition, with the explosion of educational technology, linking students on a global basis is more easily accomplished. This technology is bringing national and international issues into the classroom, including global environmental issues, the global marketplace, and global collaboration in space. We present the successes and lessons learned concerning international educational and public outreach programs that we have been involved in for NASA as well as the importance of sustaining these international peer collaborative programs for the future generations. These programs will undoubtedly be critical in enhancing the classroom environment and will affect the achievements in and attitudes towards science, technology, engineering and mathematics.
Environmental issues and economic performance of the coal industry in Brazil
DOE Office of Scientific and Technical Information (OSTI.GOV)
Santana, E.A.; Seabra, F.; Wendhausen, J.
1996-12-31
The purpose of this study is to investigate the main sources of inefficiency of the Brazilian coal industry. In addition, the authors examine the current and the future competitiveness of the Brazilian coal industry taking into account the effects of globalization, the modernization of the mining techniques and, most important, the environmental costs regarded under the concept of sustainable development. This paper examines some of the causes behind the alleged inefficiency of coal production and coal-electric generation, with special emphasis to environmental issues. The rest of the paper is organized as follows. Section 2 outlines a profile of the energeticmore » potential of coal reserves in Brazil. In section 3, the authors discuss environmental restrictions and other features that can be related to the performance of the coal industry in Brazil.« less
USSR Space Life Sciences Digest, issue 2
NASA Technical Reports Server (NTRS)
Hooke, L. R. (Editor); Radtke, M. (Editor); Garshnek, V. (Editor); Rowe, J. E. (Editor); Teeter, R. (Editor)
1985-01-01
The second issue of the bimonthly digest of USSR Space Life Sciences is presented. Abstracts are included for 39 Soviet periodical articles in 16 areas of aerospace medicine and space biology and published in Russian during the first half of 1985. Selected articles are illustrated with figures from the original. Translated introductions and tables of contents for 14 Russian books on 11 topics related to NASA's life science concerns are presented. Areas covered are: adaptation, biospheric, body fluids, botany, cardiovascular and respiratory systems, cybernetics and biomedical data processing, gastrointestinal system, group dynamics, habitability and environmental effects, health and medical treatment, hematology, immunology, life support systems, metabolism, musculoskeletal system, neurophysiology, psychology, radiobiology, and space biology. Two book reviews translated from Russian are included and lists of additional relevant titles available either in English or in Russian only are appended.
A Flight Deck Perspective of Self-Separation
NASA Technical Reports Server (NTRS)
Lozito, Sandra; Rosekind, Mark (Technical Monitor)
1997-01-01
I will be participating on a Free Flight Human Factors Panel at the Ninth International Symposium on Aviation Psychology in Columbus, Ohio. My representation is related to the work that our group has conducted on flight deck issues associate with free flight. Our group completed a full-mission simulation study investigating procedural issues associated with airborne self-separation. Ten crews flew eight scenarios each in the B747-400 simulator at Ames. Each scenario had a representation of different conflict geometries with intruder aircraft. New alerting logic was created and integrated into the simulator to enable self-separation. In addition, new display features were created to help provide for enhanced information to the flight crew about relevant aircraft, The participants were asked to coordinate maneuvers for self-separation with the intruder aircraft. Data analyses for the many of the crew procedures have been completed.
Babovic, Sonja; Wasan, Kishor M
2011-03-01
This is a commentary on how the trade-related aspects of intellectual property rights (TRIPS) agreement has impacted India as a supplier of generic antiretrovirals (ARVs). We provide a systematic review of the issues related to the TRIPS agreement that affects India. This includes discussion around (a) the legal landscape underpinning India as a supplier of generic ARVs; (b) supply of second-line ARVs; and (c) the future of generic drug production in India. The proclamation into force of TRIPS-compliant intellectual property law in India is likely to affect its position as a supplier of affordable ARVs, especially drugs brought to market after 2005. Currently, mechanisms exist for the generic production of almost all ARVs in India, including second-line drugs; however, the manufacture of these drugs by generic pharmaceutical companies may require additional market incentives. Compulsory licensing may emerge as an additional mechanism by which India can provide affordable versions of patented drugs to Least Developed Countries (LDCs). Copyright © 2010 Wiley-Liss, Inc.
Clinical, Genetic and Environmental Factors Associated with Congenital Vertebral Malformations
Giampietro, P.F.; Raggio, C.L.; Blank, R.D.; McCarty, C.; Broeckel, U.; Pickart, M.A.
2013-01-01
Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital scoliosis and kyphosis, in addition to various syndromes and other congenital malformations. Additional information remains to be learned regarding the natural history of congenital scoliosis and related health problems. Although significant progress has been made in understanding the process of somite formation, which gives rise to vertebral bodies, there is a wide gap in our understanding of how genetic factors contribute to CVM development. Maternal diabetes during pregnancy most commonly contributes to the occurrence of CVM, followed by other factors such as hypoxia and anticonvulsant medications. This review highlights several emerging clinical issues related to CVM, including pulmonary and orthopedic outcome in congenital scoliosis. Recent breakthroughs in genetics related to gene and environment interactions associated with CVM development are discussed. The Klippel-Feil syndrome which is associated with cervical segmentation abnormalities is illustrated as an example in which animal models, such as the zebrafish, can be utilized to provide functional evidence of pathogenicity of identified mutations. PMID:23653580
Code of Federal Regulations, 2014 CFR
2014-01-01
... Energy Act of 2008 (Pub. L. 110-246). (12) Related to climate change. (i) Coordinate policy analysis, long-range planning, research, and response strategies relating to climate change issues. (ii) Provide... climate change issues. (iii) Inform the Department of scientific developments and policy issues relating...
NASA Technical Reports Server (NTRS)
Joyner, Michael
2009-01-01
The Cardiovascular Risk Standing Review Panel (SRP) evaluated several cardiovascular risks associated with space flight along with the ongoing and emerging plans to study these issues and potentially propose and/or develop countermeasures. The areas of focus included: 1) The risk of cardiac rhythm problems during prolonged space flight, and 2) Issues related to the risk of orthostatic intolerance during re-exposure to gravity. An emerging area of concern is radiation associated vascular injury. The risk of cardiac rhythm disturbances has emerged based on case reports only. No systematic study of this risk has been published. However, concerns about this risk are heightened by the age range of astronauts, the structural changes in the heart that occur during space flight, and the potential shifts in fluids and electrolytes. The current plan is to use prolonged Holter monitor EKG records made as part of the "Integrated Cardiovascular SMO" in space to determine more about the frequency and magnitude of this problem and to link this data to complementary data from the nutrition group on electrolytes. The SRP was supportive of this approach. The SRP also felt that any data related to cardiovascular risk in space should be better coordinated with the medical screening data that all astronauts undergo at regular intervals. Additionally, while there are potential privacy issues related to this suggestion, many of the current barriers to better coordination of experimental and clinical data appear to reflect longstanding cultural traditions at NASA that need rethinking. The risk of orthostatic intolerance during re-exposure to gravity was seen by the SRP as an area supported by a wealth of published physiological evidence. The SRP also felt that moving forward with the planned approach to countermeasures was reasonable and that extensive additional hypothesis testing on the physiology of orthostatic intolerance was not needed at this time. There was support for developing ground based models of limited (e.g. 1/6 th) G environments on Earth that generated a number of ideas for consideration by NASA investigators.
Absolute versus relative intensity of physical activity in a dose-response context.
Shephard, R J
2001-06-01
To examine the importance of relative versus absolute intensities of physical activity in the context of population health. A standard computer-search of the literature was supplemented by review of extensive personal files. Consensus reports (Category D Evidence) have commonly recommended moderate rather than hard physical activity in the context of population health. Much of the available literature provides Category C Evidence. It has often confounded issues of relative intensity with absolute intensity or total weekly dose of exercise. In terms of cardiovascular health, there is some evidence for a threshold intensity of effort, perhaps as high as 6 METs, in addition to a minimum volume of physical activity. Decreases in blood pressure and prevention of stroke seem best achieved by moderate rather than high relative intensities of physical activity. Many aspects of metabolic health depend on the total volume of activity; moderate relative intensities of effort are more effective in mobilizing body fat, but harder relative intensities may help to increase energy expenditures postexercise. Hard relative intensities seem needed to augment bone density, but this may reflect an associated increase in volume of activity. Hard relative intensities of exercise induce a transient immunosuppression. The optimal intensity of effort, relative or absolute, for protection against various types of cancer remains unresolved. Acute effects of exercise on mood state also require further study; long-term benefits seem associated with a moderate rather than a hard relative intensity of effort. The importance of relative versus absolute intensity of effort depends on the desired health outcome, and many issues remain to be resolved. Progress will depend on more precise epidemiological methods of assessing energy expenditures and studies that equate total energy expenditures between differing relative intensities. There is a need to focus on gains in quality-adjusted life expectancy.
The 2015 Nucleic Acids Research Database Issue and molecular biology database collection.
Galperin, Michael Y; Rigden, Daniel J; Fernández-Suárez, Xosé M
2015-01-01
The 2015 Nucleic Acids Research Database Issue contains 172 papers that include descriptions of 56 new molecular biology databases, and updates on 115 databases whose descriptions have been previously published in NAR or other journals. Following the classification that has been introduced last year in order to simplify navigation of the entire issue, these articles are divided into eight subject categories. This year's highlights include RNAcentral, an international community portal to various databases on noncoding RNA; ValidatorDB, a validation database for protein structures and their ligands; SASBDB, a primary repository for small-angle scattering data of various macromolecular complexes; MoonProt, a database of 'moonlighting' proteins, and two new databases of protein-protein and other macromolecular complexes, ComPPI and the Complex Portal. This issue also includes an unusually high number of cancer-related databases and other databases dedicated to genomic basics of disease and potential drugs and drug targets. The size of NAR online Molecular Biology Database Collection, http://www.oxfordjournals.org/nar/database/a/, remained approximately the same, following the addition of 74 new resources and removal of 77 obsolete web sites. The entire Database Issue is freely available online on the Nucleic Acids Research web site (http://nar.oxfordjournals.org/). Published by Oxford University Press on behalf of Nucleic Acids Research 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Fertility and pregnancy issues in BRCA-mutated breast cancer patients.
Lambertini, Matteo; Goldrat, Oranite; Toss, Angela; Azim, Hatem A; Peccatori, Fedro A; Ignatiadis, Michail; Del Mastro, Lucia; Demeestere, Isabelle
2017-09-01
Fertility and pregnancy-related issues represent one of the main areas of concerns for young women with breast cancer. Carrying a germline deleterious BRCA mutation adds additional burden on this regard due to the specific issues that should be considered during the oncofertility counseling of this special patient group. Despite the availability of a growing amount of data in the general breast cancer population on the feasibility and safety of fertility preservation and pregnancy after diagnosis, numerous challenges remain for BRCA-mutated breast cancer patients in whom very limited studies have been performed so far. Therefore, studies aiming to address the specific issues of these patients, including the impact of the mutation on their fertility potential, the safety and efficacy of the different strategies for fertility preservation, and the feasibility of having a pregnancy after diagnosis, should be considered a research priority. The aim of the present manuscript is to perform an in depth overview on the role of BRCA mutations in breast cancer with a specific focus on their impact on reproductive potential, and to discuss the fertility and pregnancy issues faced by BRCA-mutated breast cancer patients. The final goal of this manuscript is to highlight current and upcoming knowledge in this field for trying to help physicians dealing with these patients during oncofertility counseling. Copyright © 2017 Elsevier Ltd. All rights reserved.
Juvenile, insulin-dependent diabetes mellitus, type 1-related dermatoses.
Sehgal, V N; Bhattacharya, S N; Verma, P
2011-06-01
Juvenile insulin-dependent diabetes mellitus type 1 (IDDM) is a well-recognized worldwide entity, the significance of which has increased because of its recent upsurging trends, warranting attention on variety of its clinical expressions, in particular, pertaining to skin, an aspect seldom taken cognizance of. Hence an endeavour to recap the related dermatoses, such as limited joint mobility syndrome including sclerodermoid (scleroderma-like) changes, xerosis, necrobiosis lipoidica diabeticorum, granuloma annulare, diabetic foot syndrome, has been made. Complexities relating to the recently explored issues of atopic dermatitis and drug hypersensitivity syndrome have also been covered adequately. In addition, the current concepts of the physiopathology of type 1 diabetes-related dermatoses are briefly recapitulated for clarity. © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.
Joekes, Katherine; Van Elderen, Thérèse; Schreurs, Karlein
2007-01-01
This repeated-measures study explores how self-efficacy and overprotection relate to psychological well-being, health-related quality of life and self-management. Eighty-two cardiac patients, suffering from congestive heart failure (CHF) or myocardial infarction (MI), completed questionnaires at T1 and three months later. Perceived overprotection is associated with concurrent levels of anxiety and depression, and lowered quality of life. Self-efficacy is related to psychological well-being in both patient groups, but only associated with quality of life in CHF patients. In addition, self-efficacy predicts MI patients' self-management behaviours in the medium term. Findings have implications for cardiac rehabilitation, where attention may usefully be focused on enhancing self-efficacy and dealing with issues of support and overprotection by the partner.
Role of Plastics on Human Health.
Kumar, Pramod
2018-05-01
Plastics, currently the universal workhorse materials of modern economy, because of their low cost and varied functional properties are posing serious threat to environment and consumer's health in many direct and indirect ways. Rising concern about the impact of plastics on environment and human health, has forced the industry to look for alternatives. This review studies current understanding of benefits and concerns surrounding use of plastics, reviews literature about health effects in humans and discusses the current state of evidence, as well as future research trends. There is increasing concern regarding additives in plastics to which most people are exposed, such as phthalates, bisphenol A or polybrominated diphenyl ethers (PBDE), and their detection in humans, leading to harmful impact on health. The studies are divided, among many other issues on the fact of considering these additives as carcinogens or toxicants, but there is a consensus that these chemicals have the ability to alter the endocrine system. Human data are limited compared to large body of experimental evidence documenting reproductive or developmental toxicity in relation to these compounds in animals. The concentrations of these additives in young children, a segment particularly sensitive to exogenous insults, are typically higher, indicating the need to decrease exposure to these compounds. The rapid increase in usage of plastics and increased awareness about its health hazard has lent urgency to the whole issue.
Ethical Issues and Practical Challenges in Suicide Research.
Hom, Melanie A; Podlogar, Matthew C; Stanley, Ian H; Joiner, Thomas E
2017-03-01
Research with human subjects represents a critical avenue for suicide prevention efforts; however, such research is not without its ethical and practical challenges. Specifically, given the nature of research with individuals at elevated risk for suicide (e.g., increased concerns regarding participant safety, adverse events, liability, difficulties often arise during the institutional review board (IRB) evaluation and approval process. This paper aims to discuss IRB-related issues associated with suicide prevention research, including researcher and IRB panel member responsibilities, suicide risk assessment and management ethics and procedures, informed consent considerations, preparation of study protocols, and education and training. Points to consider and components to potentially include in an IRB application for suicide-related research are additionally provided. Literature relevant to ethics in suicide research and suicide risk assessment and management was reviewed and synthesized. Suicide research can be conducted in accordance with ethical principles while also furthering the science of suicide prevention. Despite the challenging nature of suicide prevention research, empirically informed solutions exist to address difficulties that may emerge in interfacing with IRBs. There remain areas for improvement in the IRB approval process that warrant further investigation and work.
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-29
...This final rule with comment period addresses changes to the physician fee schedule and other Medicare Part B payment policies to ensure that our payment systems are updated to reflect changes in medical practice and the relative value of services. It finalizes the calendar year (CY) 2010 interim relative value units (RVUs) and issues interim RVUs for new and revised procedure codes for CY 2011. It also addresses, implements, or discusses certain provisions of both the Affordable Care Act (ACA) and the Medicare Improvements for Patients and Providers Act of 2008 (MIPPA). In addition, this final rule with comment period discusses payments under the Ambulance Fee Schedule (AFS), the Ambulatory Surgical Center (ASC) payment system, and the Clinical Laboratory Fee Schedule (CLFS), payments to end-stage renal disease (ESRD) facilities, and payments for Part B drugs. Finally, this final rule with comment period also includes a discussion regarding the Chiropractic Services Demonstration program, the Competitive Bidding Program for durable medical equipment, prosthetics, orthotics, and supplies (CBP DMEPOS), and provider and supplier enrollment issues associated with air ambulances.
2013 Monitoring and tracking wet nitrogen deposition at Rocky Mountain National Park
Morris, Kristi; Mast, M. Alisa; Clow, David W.; Wetherbee, Gregory A.; Baron, Jill S.; Taipale, Curt; Blett, Tamara; Gay, David A.; Bowker, Daniel
2015-01-01
In 2004, multiple agencies including the Colorado Department of Public Health and Environment (CDPHE), the National Park Service (NPS), and the U.S. Environmental Protection Agency (U.S. EPA) met to address the effects and trends of nitrogen deposition and related air quality issues at Rocky Mountain National Park (RMNP). These agencies signed a Memorandum of Understanding (MOU) to facilitate interagency coordination, calling the effort the “Rocky Mountain National Park Initiative.” After much collaboration, the MOU agencies (CDPHE, NPS, and U.S. EPA) issued the Nitrogen Deposition Reduction Plan (NDRP) in 2007, which was endorsed by the three agencies and the Colorado Air Quality Control Commission (AQCC). The NDRP and other related documents are available on the CDPHE website: http://www.colorado.gov/cdphe/rmnpinitiative. The purpose of this report is to inform the MOU agencies, stakeholders, and the public about the status and trends of wet nitrogen deposition at RMNP through 2013. In addition to other types of evidence, the MOU agencies use the information provided in this annual report to determine interim milestone achievements.
Feminist conceptualizations of women's madness: a review of the literature.
Wright, N; Owen, S
2001-10-01
Gender is one aspect of an individual's identity that has been widely debated and discussed in relation to many different aspects of social life. The literature review explores how gender stereotypes affect women and their experience of mental illness. The aim is to demonstrate how a feminist perspective provides a useful lens through which women's experience of mental illness can be viewed. The papers were identified by a computerized search of the CINAHL, Medline, BIDS ISI and Mental Health Nursing Collection databases and a hand search. All papers were screened and subjected to critical review. A theoretical framework was developed that reflected two key themes to emerge from the feminist literature on women and mental illness, namely psychiatry as a method of socially controlling women and the medicalization of women's unhappiness. In addition the complexities and contradictions in the feminist arguments are highlighted. The paper concludes by considering the implications of the issues raised for nursing practice by drawing attention to the current debates on the need to focus on gender relations rather than just on women's issues.
NASA Technical Reports Server (NTRS)
VanDyke, M. K.; Martin, J. J.; Houts, M. G.
2003-01-01
Successful development of space fission systems will require an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. At the power levels under consideration (3-300 kW electric power), almost all technical issues are thermal or stress related and will not be strongly affected by the radiation environment. These issues can be resolved more thoroughly, less expensively, and in a more timely fashing with nonnuclear testing, provided it is prototypic of the system in question. This approach was used for the safe, affordable fission engine test article development program and accomplished viz cooperative efforts with Department of Energy labs, industry, universiites, and other NASA centers. This Technical Memorandum covers the analysis, testing, and data reduction of a 30-kW simulated reactor as well as an end-to-end demonstrator, including a power conversion system and an electric propulsion engine, the first of its kind in the United States.
Reliability Issues in Stirling Radioisotope Power Systems
NASA Technical Reports Server (NTRS)
Schreiber, Jeffrey; Shah, Ashwin
2005-01-01
Stirling power conversion is a potential candidate for use in a Radioisotope Power System (RPS) for space science missions because it offers a multifold increase in the conversion efficiency of heat to electric power and reduced requirement of radioactive material. Reliability of an RPS that utilizes Stirling power conversion technology is important in order to ascertain long term successful performance. Owing to long life time requirement (14 years), it is difficult to perform long-term tests that encompass all the uncertainties involved in the design variables of components and subsystems comprising the RPS. The requirement for uninterrupted performance reliability and related issues are discussed, and some of the critical areas of concern are identified. An overview of the current on-going efforts to understand component life, design variables at the component and system levels, and related sources and nature of uncertainties are also discussed. Current status of the 110 watt Stirling Radioisotope Generator (SRG110) reliability efforts is described. Additionally, an approach showing the use of past experience on other successfully used power systems to develop a reliability plan for the SRG110 design is outlined.
Novel approaches to improving the chemical safety of the meat chain towards toxicants.
Engel, E; Ratel, J; Bouhlel, J; Planche, C; Meurillon, M
2015-11-01
In addition to microbiological issues, meat chemical safety is a growing concern for the public authorities, chain stakeholders and consumers. Meat may be contaminated by various chemical toxicants originating from the environment, treatments of agricultural production or food processing. Generally found at trace levels in meat, these toxicants may harm human health during chronic exposure. This paper overviews the key issues to be considered to ensure better control of their occurrence in meat and assessment of the related health risk. We first describe potential contaminants of meat products. Strategies to move towards a more efficient and systematic control of meat chemical safety are then presented in a second part, with a focus on emerging approaches based on toxicogenomics. The third part presents mitigation strategies to limit the impact of process-induced toxicants in meat. Finally, the last part introduces methodological advances to refine chemical risk assessment related to the occurrence of toxicants in meat by quantifying the influence of digestion on the fraction of food contaminants that may be assimilated by the human body. Copyright © 2015 Elsevier Ltd. All rights reserved.
Long-term outcomes of adults with features of VACTERL association
Raam, Manu S.; Pineda-Alvarez, Daniel E.; Hadley, Donald W.; Solomon, Benjamin D.
2010-01-01
VACTERL association involves the presence of specific congenital, multi-organ malformations that tend to co-occur. Clinical and research efforts typically center on pediatric patients, and there is a scarcity of information in the literature regarding VACTERL-related issues and outcomes in adulthood. We describe here 11 adults with features of VACTERL association ascertained through our research study on the condition. In our cohort of adult patients, approximately 25% of medically significant malformations that are component features of VACTERL association, including 40% of vertebral, 50% of cardiac, and 50% of renal anomalies, were not identified during childhood. Additionally, medical sequelae of many of the primary malformations identified in infancy or early childhood persist or are first reported in adulthood. These sequelae can involve challenging medical and surgical management in adulthood. As most adults with VACTERL association are not specifically followed for VACTERL-related issues, a more uniform diagnostic work-up and a low threshold for investigation of medical sequelae of the primary disorder may enhance the quality of clinical management in these patients. PMID:20888933
WSN- and IOT-Based Smart Homes and Their Extension to Smart Buildings
Ghayvat, Hemant; Mukhopadhyay, Subhas; Gui, Xiang; Suryadevara, Nagender
2015-01-01
Our research approach is to design and develop reliable, efficient, flexible, economical, real-time and realistic wellness sensor networks for smart home systems. The heterogeneous sensor and actuator nodes based on wireless networking technologies are deployed into the home environment. These nodes generate real-time data related to the object usage and movement inside the home, to forecast the wellness of an individual. Here, wellness stands for how efficiently someone stays fit in the home environment and performs his or her daily routine in order to live a long and healthy life. We initiate the research with the development of the smart home approach and implement it in different home conditions (different houses) to monitor the activity of an inhabitant for wellness detection. Additionally, our research extends the smart home system to smart buildings and models the design issues related to the smart building environment; these design issues are linked with system performance and reliability. This research paper also discusses and illustrates the possible mitigation to handle the ISM band interference and attenuation losses without compromising optimum system performance. PMID:25946630
NASA Technical Reports Server (NTRS)
Johnson, Walter W.; Kaiser, Mary K.
2003-01-01
Perspective synthetic displays that supplement, or supplant, the optical windows traditionally used for guidance and control of aircraft are accompanied by potentially significant human factors problems related to the optical geometric conformality of the display. Such geometric conformality is broken when optical features are not in the location they would be if directly viewed through a window. This often occurs when the scene is relayed or generated from a location different from the pilot s eyepoint. However, assuming no large visual/vestibular effects, a pilot cad often learn to use such a display very effectively. Important problems may arise, however, when display accuracy or consistency is compromised, and this can usually be related to geometrical discrepancies between how the synthetic visual scene behaves and how the visual scene through a window behaves. In addition to these issues, this paper examines the potentially critical problem of the disorientation that can arise when both a synthetic display and a real window are present in a flight deck, and no consistent visual interpretation is available.
Reliability Issues in Stirling Radioisotope Power Systems
NASA Technical Reports Server (NTRS)
Shah, Ashwin R.; Schreiber, Jeffrey G.
2004-01-01
Stirling power conversion is a potential candidate for use in a Radioisotope Power System (RPS) for space science missions because it offers a multifold increase in the conversion efficiency of heat to electric power and reduced requirement of radioactive material. Reliability of an RPS that utilizes Stirling power conversion technology is important in order to ascertain long term successful performance. Owing to long life time requirement (14 years), it is difficult to perform long-term tests that encompass all the uncertainties involved in the design variables of components and subsystems comprising the RPS. The requirement for uninterrupted performance reliability and related issues are discussed, and some of the critical areas of concern are identified. An overview of the current on-going efforts to understand component life, design variables at the component and system levels, and related sources and nature of uncertainties are also discussed. Current status of the 110 watt Stirling Radioisotope Generator (SRG110) reliability efforts is described. Additionally, an approach showing the use of past experience on other successfully used power systems to develop a reliability plan for the SRG110 design is outlined.
WSN- and IOT-Based Smart Homes and Their Extension to Smart Buildings.
Ghayvat, Hemant; Mukhopadhyay, Subhas; Gui, Xiang; Suryadevara, Nagender
2015-05-04
Our research approach is to design and develop reliable, efficient, flexible, economical, real-time and realistic wellness sensor networks for smart home systems. The heterogeneous sensor and actuator nodes based on wireless networking technologies are deployed into the home environment. These nodes generate real-time data related to the object usage and movement inside the home, to forecast the wellness of an individual. Here, wellness stands for how efficiently someone stays fit in the home environment and performs his or her daily routine in order to live a long and healthy life. We initiate the research with the development of the smart home approach and implement it in different home conditions (different houses) to monitor the activity of an inhabitant for wellness detection. Additionally, our research extends the smart home system to smart buildings and models the design issues related to the smart building environment; these design issues are linked with system performance and reliability. This research paper also discusses and illustrates the possible mitigation to handle the ISM band interference and attenuation losses without compromising optimum system performance.
ERIC Educational Resources Information Center
Ashby, Nicole, Ed.
2001-01-01
This document consists of 10 issues (covering January through December 2000) of the newsletter, "Community Update," which features articles on community and family involvement in education. In addition to the articles, each issue (except the Special Issue) includes a preview of the month's Satellite Town Meeting; events and information…
Current knowledge and trends in age-related macular degeneration: today's and future treatments.
Velez-Montoya, Raul; Oliver, Scott C N; Olson, Jeffrey L; Fine, Stuart L; Mandava, Naresh; Quiroz-Mercado, Hugo
2013-09-01
To address the most dynamic and current issues concerning today's treatment options and promising research efforts regarding treatment for age-related macular degeneration. This review is aimed to serve as a practical reference for more in-depth reviews on the subject. An online review of the database PubMed and Ovid were performed, searching for the key words age-related macular degeneration, AMD, VEGF, treatment, PDT, steroids, bevacizumab, ranibizumab, VEGF-trap, radiation, combined therapy, as well as their compound phrases. The search was limited to articles published since 1985. All returned articles were carefully screened, and their references were manually reviewed for additional relevant data. The web page www.clinicaltrials.gov was also accessed in search of relevant research trials. A total of 363 articles were reviewed, including 64 additional articles extracted from the references. At the end, only 160 references were included in this review. Treatment for age-related macular degeneration is a very dynamic research field. While current treatments are mainly aimed at blocking vascular endothelial growth factor, future treatments seek to prevent vision loss because of scarring. Promising efforts have been made to address the dry form of the disease, which has lacked effective treatment.
Issues Management and the Use of Technologies in Public Relations.
ERIC Educational Resources Information Center
Ramsey, Shirley A.
1993-01-01
Finds that members of the Issues Management Association were more positively involved with two procedures--"environmental scanning for emerging issues" and "developing communication plans about the issues"--than were other public relations practitioners. Finds that respondents were highly likely to use advanced communication…
Psychological and Neural Mechanisms of Experimental Extinction: A Selective Review
Delamater, Andrew R.; Westbrook, R. Frederick
2013-01-01
The present review examines key psychological concepts in the study of experimental extinction and implications these have for an understanding of the underlying neurobiology of extinction learning. We suggest that many of the signature characteristics of extinction learning (spontaneous recovery, renewal, reinstatement, rapid reacquisition) can be accommodated by the standard associative learning theory assumption that extinction results in partial erasure of the original learning together with new inhibitory learning. Moreover, we consider recent behavioral and neural evidence that supports the partial erasure view of extinction, but also note shortcomings in our understanding of extinction circuits as these relate to the negative prediction error concept. Recent work suggests that common prediction error and stimulus-specific prediction error terms both may be required to explain neural plasticity both in acquisition and extinction learning. In addition, we suggest that many issues in the content of extinction learning have not been fully addressed in current research, but that neurobiological approaches should be especially helpful in addressing such issues. These include questions about the nature of extinction learning (excitatory CS-No US, inhibitory CS-US learning, occasion setting processes), especially as this relates to studies of the micro-circuitry of extinction, as well as its representational content (sensory, motivational, response). An additional understudied problem in extinction research is the role played by attention processes and their underlying neural networks, although some research and theory converge on the idea that extinction is accompanied by attention decrements (i.e., habituation-like processes). PMID:24104049
Psychological and neural mechanisms of experimental extinction: a selective review.
Delamater, Andrew R; Westbrook, R Frederick
2014-02-01
The present review examines key psychological concepts in the study of experimental extinction and implications these have for an understanding of the underlying neurobiology of extinction learning. We suggest that many of the signature characteristics of extinction learning (spontaneous recovery, renewal, reinstatement, rapid reacquisition) can be accommodated by the standard associative learning theory assumption that extinction results in partial erasure of the original learning together with new inhibitory learning. Moreover, we consider recent behavioral and neural evidence that supports the partial erasure view of extinction, but also note shortcomings in our understanding of extinction circuits as these relate to the negative prediction error concept. Recent work suggests that common prediction error and stimulus-specific prediction error terms both may be required to explain neural plasticity both in acquisition and extinction learning. In addition, we suggest that many issues in the content of extinction learning have not been fully addressed in current research, but that neurobiological approaches should be especially helpful in addressing such issues. These include questions about the nature of extinction learning (excitatory CS-No US, inhibitory CS-US learning, occasion setting processes), especially as this relates to studies of the micro-circuitry of extinction, as well as its representational content (sensory, motivational, response). An additional understudied problem in extinction research is the role played by attention processes and their underlying neural networks, although some research and theory converge on the idea that extinction is accompanied by attention decrements (i.e., habituation-like processes). Copyright © 2013 Elsevier Inc. All rights reserved.
A Decision Support System for effective use of probability forecasts
NASA Astrophysics Data System (ADS)
De Kleermaeker, Simone; Verkade, Jan
2013-04-01
Often, water management decisions are based on hydrological forecasts. These forecasts, however, are affected by inherent uncertainties. It is increasingly common for forecasting agencies to make explicit estimates of these uncertainties and thus produce probabilistic forecasts. Associated benefits include the decision makers' increased awareness of forecasting uncertainties and the potential for risk-based decision-making. Also, a stricter separation of responsibilities between forecasters and decision maker can be made. However, simply having probabilistic forecasts available is not sufficient to realise the associated benefits. Additional effort is required in areas such as forecast visualisation and communication, decision making in uncertainty and forecast verification. Also, revised separation of responsibilities requires a shift in institutional arrangements and responsibilities. A recent study identified a number of additional issues related to the effective use of probability forecasts. When moving from deterministic to probability forecasting, a dimension is added to an already multi-dimensional problem; this makes it increasingly difficult for forecast users to extract relevant information from a forecast. A second issue is that while probability forecasts provide a necessary ingredient for risk-based decision making, other ingredients may not be present. For example, in many cases no estimates of flood damage, of costs of management measures and of damage reduction are available. This paper presents the results of the study, including some suggestions for resolving these issues and the integration of those solutions in a prototype decision support system (DSS). A pathway for further development of the DSS is outlined.
Huffman, Laura B.; Hartenbach, Ellen M.; Carter, Jeanne; Rash, Joanne K.; Kushner, David M.
2016-01-01
Objective The diagnosis and treatment of gynecologic cancer can cause short- and long-term negative effects on sexual health and quality of life (QoL). The aim of this article is to present a comprehensive overview of the sexual health concerns of gynecologic cancer survivors and discuss evidence-based treatment options for commonly encountered sexual health issues. Methods A comprehensive literature search of English language studies on sexual health in gynecologic cancer survivors and the treatment of sexual dysfunction was conducted in MEDLINE databases. Relevant data are presented in this review. Additionally, personal and institutional practices are incorporated where relevant. Results Sexual dysfunction is prevalent among gynecologic cancer survivors as a result of surgery, radiation, and chemotherapy--negatively impacting QoL. Many patients expect their healthcare providers to address sexual health concerns, but most have never discussed sex-related issues with their physician. Lubricants, moisturizers, and dilators are effective, simple, non-hormonal interventions that can alleviate the morbidity of vaginal atrophy, stenosis, and pain. Pelvic floor physical therapy can be an additional tool to address dyspareunia. Cognitive behavioral therapy has been shown to be beneficial to patients reporting problems with sexual interest, arousal, and orgasm. Conclusion Oncology providers can make a significant impact on the QoL of gynecologic cancer survivors by addressing sexual health concerns. Simple strategies can be implemented into clinical practice to discuss and treat many sexual issues. Referral to specialized sexual health providers may be needed to address more complex problems. PMID:26556768
DOE Office of Scientific and Technical Information (OSTI.GOV)
None
2009-01-01
Since September 11, 2001, the Department of Energy has, on several occasions, revised its security posture based on identified threats and adversaries. These revisions in security posture have driven Departmental sites to upgrade their defensive and tactical equipment. Subsequent changes in the perceived threats have, in some cases, led to a reduction in the need for certain types of weapons, thus creating a pool of surplus equipment. These surplus weapons could potentially be used by other Department sites and Federal law enforcement agencies. Recent Office of Inspector General reports have raised concerns with the adequacy of controls related to defensivemore » and tactical equipment. For example, our report on Management Controls Over Defense Related High Risk Property (OAS-M-08-06, April 2008) found that administrative controls over certain defense related high risk property were not sufficient for providing accountability over these items. Because of prior reported weaknesses in controls over defensive and tactical equipment, we initiated this audit to determine whether the Department and its contractors were properly managing excess weapons inventories and selected sensitive equipment used by protective forces. Our review disclosed that the Department was not always properly managing its inventories of excess weapons and selected sensitive equipment. We identified issues with the retention of unneeded weapons at many locations and with the identification and tracking of sensitive items. More specifically: Sites maintained large inventories of weapons that were no longer needed but had not been made available for use by either other Departmental sites or other Federal law enforcement agencies. For instance, at six of the locations included in our review we identified a total of 2,635 unneeded weapons with a total acquisition value of over $2.8 million that had not been officially declared as excess - an action that would have made them available for others to use. In addition; Sites were not always identifying, tracking and properly disposing of potentially high risk and sensitive equipment. In particular, we identified control weaknesses in this area related to weapons sights and scopes. These issues occurred because the Department did not have processes in place to properly manage excess inventories of weapons. In particular, the Department does not have requirements for ensuring timely declaration of excess weapons. Additionally, certain sites indicated that they were unwilling to give up excess weapons because of the possibility that they may be needed in the future. However, other sites had a need for some of these weapons and could have avoided purchasing them had they been made available through the excess screening process. Also, we found that the Department lacks clear guidance on the identification of high risk/sensitive equipment. Except for immaterial differences, we were able to locate and verify accountability over the items of defensive and tactical equipment we selected for review. Specifically, we took statistical samples of weapons, ammunition, and other related equipment and were able to verify their existence. While these accountability measures were noteworthy, additional action is necessary to strengthen controls over weapon and sensitive equipment management. Untimely declaration of excess weapons may result in an inefficient use of scarce Government resources. Similarly, if selected high risk/sensitive equipment is not properly categorized and tracked, accountability issues may occur. To address these issues, we made recommendations aimed at improving the management of these categories of defensive and tactical equipment.« less
An online forum as a qualitative research method: practical issues.
Im, Eun-Ok; Chee, Wonshik
2006-01-01
Despite the positive aspects of online forums as a qualitative research method, very little is known on the practical issues involved in using online forums for data collection, especially for a qualitative research project. The aim of this study was to describe the practical issues encountered in implementing an online forum as a qualitative component of a larger study on cancer pain experience. Throughout the study process, the research staff recorded issues ranging from minor technical problems to serious ethical dilemmas as they arose and wrote memos about them. The memos and written records of the discussions were reviewed and analyzed using content analysis. Two practical issues related to credibility were identified: (a) a high response and retention rate and (b) automatic transcripts. An issue related to dependability was the participants' forgetfulness. The issues related to confirmability were difficulties in theoretical saturation and unstandardized computer and Internet jargon. A security issue related to hacking attempts was noted as well. The analysis of these issues suggests several implications for future researchers who want to use online forums as a qualitative data collection method.
MacLure, Katie; MacLeod, Joan; Forbes-McKay, Katrina; Paudyal, Vibhu; Cunningham, Scott; Strath, Alison; Lynch, Rory; Stewart, Derek
2016-12-01
Multi-compartment compliance aids (MCAs) are repackaging systems for solid dosage form medicines, heralded by some as a solution to non-adherence but with little evidence of benefit. The aim was to use a theoretical approach to describe the behavioural determinants impacting the use of MCAs in older people from the perspectives of the individual and health and social care providers. A case study investigation was conducted. The study took place in three very sheltered housing sites in North East Scotland. Twenty residents (≥65 years) using an MCA for at least 6 months and 34 members of their care team [17 formal carers, eight general practitioners (GPs), eight pharmacists, one family member]. Semi-structured, face-to-face interviews with items based on the Theoretical Domains Framework were conducted. Interviews were audio-recorded, transcribed and analysed thematically. Several behavioural determinants impacted the use of MCAs from the perspectives of the stakeholders involved. Goals of use related to promoting adherence and safety, with less emphasis on independence. Beliefs of consequences related to these goals and were considered of value, with additional consequences of concern around reduced awareness of medicines and complexities of changing medicines. There was a lack of clearly defined roles of professionals for all processes of MCA use, with evidence of blurring and gaps in roles. There were additional issues relating to capabilities of older people in using MCAs and capacity issues for pharmacy-supplied MCAs. Several behavioural determinants impacted the use of MCAs, and while MCAs were valued, there is a need to more clearly define, develop, implement and evaluate a model of care encompassing resident and medicines assessment, supply and ongoing review of MCAs.
Wetted Foam Liquid DT Layer ICF Experiments at the NIF
NASA Astrophysics Data System (ADS)
Olson, R. E.; Leeper, R. J.; Peterson, R. R.; Yi, S. A.; Zylstra, A. B.; Kline, J. L.; Bradley, P. A.; Yin, L.; Wilson, D. C.; Haines, B. M.; Batha, S. H.
2016-10-01
A key physics issue in indirect-drive ICF relates to the understanding of the limitations on hot spot convergence ratio (CR), principally set by the hohlraum drive symmetry, the capsule mounting hardware (the ``tent''), and the capsule fill tube. An additional key physics issue relates to the complex process by which a hot spot must be dynamically formed from the inner ice surface in a DT ice-layer implosion. These physics issues have helped to motivate the development of a new liquid DT layer wetted foam platform at the NIF that provides an ability to form the hot spot from DT vapor and experimentally study and understand hot spot formation at a variety of CR's in the range of 12
Kalkhoran, Sara; Hale, Lauren
2008-09-01
Inconsistent statistics about the number of HIV/AIDS cases in Iran and misinformation about HIV/AIDS among Iranian adolescents necessitate proper understanding and knowledge of HIV/AIDS transmission and prevention. This is particularly important since many issues related to HIV/AIDS, such as sex, homosexuality, and drug use, are taboo topics in the Islamic world. We analyzed Farsi-language educational and informational small media items to ascertain the nature of HIV/AIDS-related material available in society. While all of the documents mentioned sexual contact as a means of transmitting the virus, and the majority (87%) mentioned condom use as a preventive means, mention of homosexuality (43%) and prostitution (17%) was lacking in most. Thus, mention of "safe sex" strategies was not avoided due to fear of promoting sex outside of marriage, as has been noted in other Islamic nations. Mention of intravenous drug use in 90% of the documents shows an acknowledgment of the drug problem in the nation, and an effort to curb its harmful sequelae. Therefore, while certain issues such as sex, condoms, and drug use were well represented in the documents analyzed, additional inclusion of topics such as homosexuality and prostitution, issues already discussed infrequently in society, can help to better educate the population and curb the spread of this life-threatening disease.