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Sample records for additional nih resources

  1. The NIH Roadmap Epigenomics Program data resource.

    PubMed

    Chadwick, Lisa Helbling

    2012-06-01

    The NIH Roadmap Reference Epigenome Mapping Consortium is developing a community resource of genome-wide epigenetic maps in a broad range of human primary cells and tissues. There are large amounts of data already available, and a number of different options for viewing and analyzing the data. This report will describe key features of the websites where users will find data, protocols and analysis tools developed by the consortium, and provide a perspective on how this unique resource will facilitate and inform human disease research, both immediately and in the future. PMID:22690667

  2. The NIH-NIAID Filariasis Research Reagent Resource Center

    PubMed Central

    Michalski, Michelle L.; Griffiths, Kathryn G.; Williams, Steven A.; Kaplan, Ray M.; Moorhead, Andrew R.

    2011-01-01

    Filarial worms cause a variety of tropical diseases in humans; however, they are difficult to study because they have complex life cycles that require arthropod intermediate hosts and mammalian definitive hosts. Research efforts in industrialized countries are further complicated by the fact that some filarial nematodes that cause disease in humans are restricted in host specificity to humans alone. This potentially makes the commitment to research difficult, expensive, and restrictive. Over 40 years ago, the United States National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH-NIAID) established a resource from which investigators could obtain various filarial parasite species and life cycle stages without having to expend the effort and funds necessary to maintain the entire life cycles in their own laboratories. This centralized resource (The Filariasis Research Reagent Resource Center, or FR3) translated into cost savings to both NIH-NIAID and to principal investigators by freeing up personnel costs on grants and allowing investigators to divert more funds to targeted research goals. Many investigators, especially those new to the field of tropical medicine, are unaware of the scope of materials and support provided by the FR3. This review is intended to provide a short history of the contract, brief descriptions of the fiilarial species and molecular resources provided, and an estimate of the impact the resource has had on the research community, and describes some new additions and potential benefits the resource center might have for the ever-changing research interests of investigators. PMID:22140585

  3. NIH Quickfinder

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues NIH Quickfinder Past Issues / Fall 2006 Table of Contents ... information or to contact any of the following NIH institutes, centers, and offices directly, please call or ...

  4. Production scheduling with discrete and renewable additional resources

    NASA Astrophysics Data System (ADS)

    Kalinowski, K.; Grabowik, C.; Paprocka, I.; Kempa, W.

    2015-11-01

    In this paper an approach to planning of additional resources when scheduling operations are discussed. The considered resources are assumed to be discrete and renewable. In most research in scheduling domain, the basic and often the only type of regarded resources is a workstation. It can be understood as a machine, a device or even as a separated space on the shop floor. In many cases, during the detailed scheduling of operations the need of using more than one resource, required for its implementation, can be indicated. Resource requirements for an operation may relate to different resources or resources of the same type. Additional resources are most often referred to these human resources, tools or equipment, for which the limited availability in the manufacturing system may have an influence on the execution dates of some operations. In the paper the concept of the division into basic and additional resources and their planning method was shown. A situation in which sets of basic and additional resources are not separable - the same additional resource may be a basic resource for another operation is also considered. Scheduling of operations, including greater amount of resources can cause many difficulties, depending on whether the resource is involved in the entire time of operation, only in the selected part(s) of operation (e.g. as auxiliary staff at setup time) or cyclic - e.g. when an operator supports more than one machine, or supervises the execution of several operations. For this reason the dates and work times of resources participation in the operation can be different. Presented issues are crucial when modelling of production scheduling environment and designing of structures for the purpose of scheduling software development.

  5. GeneEd—A Genetics Educational Resource | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Genetics 101 GeneEd — A Genetics Educational Resource Past Issues / Summer 2013 Table of ... GeneEd website as part of her lessons on genetics. A recently developed educational website about genetics— GeneEd. ...

  6. Managing Urban School System Resources: New Procedures, Addition Actors.

    ERIC Educational Resources Information Center

    Hentschke, Guilbert C.

    In recent years urban school systems have had to face unusually severe economic constraints. In the process of adjusting to these constraints, urban systems will likely seek new ways to reallocate existing resources and will undertake more cooperative ventures with other organizational entities to gain access to additional resources. Four…

  7. Campus Grids: Bringing Additional Computational Resources to HEP Researchers

    NASA Astrophysics Data System (ADS)

    Weitzel, Derek; Fraser, Dan; Bockelman, Brian; Swanson, David

    2012-12-01

    It is common at research institutions to maintain multiple clusters that represent different owners or generations of hardware, or that fulfill different needs and policies. Many of these clusters are consistently under utilized while researchers on campus could greatly benefit from these unused capabilities. By leveraging principles from the Open Science Grid it is now possible to utilize these resources by forming a lightweight campus grid. The campus grids framework enables jobs that are submitted to one cluster to overflow, when necessary, to other clusters within the campus using whatever authentication mechanisms are available on campus. This framework is currently being used on several campuses to run HEP and other science jobs. Further, the framework has in some cases been expanded beyond the campus boundary by bridging campus grids into a regional grid, and can even be used to integrate resources from a national cyberinfrastructure such as the Open Science Grid. This paper will highlight 18 months of operational experiences creating campus grids in the US, and the different campus configurations that have successfully utilized the campus grid infrastructure.

  8. NIH Loses a Friend

    MedlinePlus

    ... work as pathology researchers. They made a tremendous team, providing NIH with outstanding competence, integrity, and vision for over 50 years. She held the most important leadership posts in recent NIH history. Dr. Ruth Kirschstein ...

  9. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... on. NIH Quickfinder and NIH Medline Plus Advisory Group Past Issues / Summer 2015 Table of Contents For ... nih.gov (301) 402-1770 NIH MedlinePlus Advisory Group Marin P. Allen, Ph.D., Office of Communications ...

  10. The Job Demands-Resources Model: An Analysis of Additive and Joint Effects of Demands and Resources

    ERIC Educational Resources Information Center

    Hu, Qiao; Schaufeli, Wilmar B.; Taris, Toon W.

    2011-01-01

    The present study investigated the additive, synergistic, and moderating effects of job demands and job resources on well-being (burnout and work engagement) and organizational outcomes, as specified by the Job Demands-Resources (JD-R) model. A survey was conducted among two Chinese samples: 625 blue collar workers and 761 health professionals. A…

  11. Aggregation of Cricket Activity in Response to Resource Addition Increases Local Diversity

    PubMed Central

    Szinwelski, Neucir; Rosa, Cassiano Sousa; Solar, Ricardo Ribeiro de Castro; Sperber, Carlos Frankl

    2015-01-01

    Crickets are often found feeding on fallen fruits among forest litter. Fruits and other sugar-rich resources are not homogeneously distributed, nor are they always available. We therefore expect that crickets dwelling in forest litter have a limited supply of sugar-rich resource, and will perceive this and displace towards resource-supplemented sites. Here we evaluate how sugar availability affects cricket species richness and abundance in old-growth Atlantic forest by spraying sugarcane syrup on leaf litter, simulating increasing availability, and collecting crickets via pitfall trapping. We found an asymptotic positive association between resource addition and species richness, and an interaction between resource addition and species identity on cricket abundance, which indicates differential effects of resource addition among cricket species. Our results indicate that 12 of the 13 cricket species present in forest litter are maintained at low densities by resource scarcity; this highlights sugar-rich resource as a short-term driver of litter cricket community structure in tropical forests. When resource was experimentally increased, species richness increased due to behavioral displacement. We present evidence that the density of many species is limited by resource scarcity and, when resources are added, behavioral displacement promotes increased species packing and alters species composition. Further, our findings have technical applicability for increasing sampling efficiency of local cricket diversity in studies aiming to estimate species richness, but with no regard to local environmental drivers or species-abundance characteristics. PMID:26436669

  12. Mineral resources of the Buffalo Hump and Sand Dunes Addition Wilderness Study Areas, Sweetwater County, Wyoming

    SciTech Connect

    Gibbons, A.B.; Barbon, H.N.; Kulik, D.M. ); McDonnell, J.R. Jr. )

    1990-01-01

    The authors present a study to assess the potential for undiscovered mineral resources and appraise the identified resources of the Buffalo Hump and Sand Dunes Addition Wilderness Study Areas, southwestern Wyoming, There are no mines, prospects, or mineralized areas nor any producing oil or gas wells; however, there are occurrences of coal, claystone and shale, and sand. There is a moderate resource potential for oil shale and natural gas and a low resource potential for oil, for metals, including uranium, and for geothermal sources.

  13. NIH Pain Consortium

    MedlinePlus

    Skip Navigation Search: header Home About PC Symposia & Meetings NIH Pain Programs Funding Opportunities Conferences & Seminars Federal Pain Activities News & Health Info Recent News Congratulations to 2016 Mitchell Max Awardee, Dr. Ditre Asst. ...

  14. NIH Loses a Friend

    MedlinePlus

    ... page please turn Javascript on. NIH Loses a Friend Past Issues / Fall 2009 Table of Contents Donald ... changingthefaceofmedicine/ . Sincerely, Donald West King, M.D., Chairman Friends of the National Library of Medicine Let Us ...

  15. Gastrointestinal disorders - resources

    MedlinePlus

    Digestive disease - resources; Resources - gastrointestinal disorders ... org American Liver Foundation -- www.liverfoundation.org National Digestive Diseases Information Clearinghouse -- digestive.niddk.nih.gov

  16. Welcome to NIH MedlinePlus, the magazine

    MedlinePlus

    ... Past Issues Welcome to NIH Medline Plus , the magazine Past Issues / Summer 2006 Table of Contents For ... MedlinePlus Web site. Your physician has made this magazine available to you as a free health resource; ...

  17. The NIH Human Microbiome Project

    PubMed Central

    Peterson, Jane; Garges, Susan; Giovanni, Maria; McInnes, Pamela; Wang, Lu; Schloss, Jeffery A.; Bonazzi, Vivien; McEwen, Jean E.; Wetterstrand, Kris A.; Deal, Carolyn; Baker, Carl C.; Di Francesco, Valentina; Howcroft, T. Kevin; Karp, Robert W.; Lunsford, R. Dwayne; Wellington, Christopher R.; Belachew, Tsegahiwot; Wright, Michael; Giblin, Christina; David, Hagit; Mills, Melody; Salomon, Rachelle; Mullins, Christopher; Akolkar, Beena; Begg, Lisa; Davis, Cindy; Grandison, Lindsey; Humble, Michael; Khalsa, Jag; Little, A. Roger; Peavy, Hannah; Pontzer, Carol; Portnoy, Matthew; Sayre, Michael H.; Starke-Reed, Pamela; Zakhari, Samir; Read, Jennifer; Watson, Bracie; Guyer, Mark

    2009-01-01

    The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 “normal” volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here. PMID:19819907

  18. Alzheimer - resources

    MedlinePlus

    Resources - Alzheimer ... The following organizations are good resources for information on Alzheimer disease : Alzheimer's Association -- www.alz.org Alzheimer's Disease Education and Referral Center -- www.nia.nih.gov/alzheimers ...

  19. Epilepsy - resources

    MedlinePlus

    Resources - epilepsy ... The following organizations are good resources for information on epilepsy : Epilepsy Foundation -- www.efa.org National Institute of Neurologic Disorders and Stroke -- www.ninds.nih.gov/disorders/ ...

  20. Additives

    NASA Technical Reports Server (NTRS)

    Smalheer, C. V.

    1973-01-01

    The chemistry of lubricant additives is discussed to show what the additives are chemically and what functions they perform in the lubrication of various kinds of equipment. Current theories regarding the mode of action of lubricant additives are presented. The additive groups discussed include the following: (1) detergents and dispersants, (2) corrosion inhibitors, (3) antioxidants, (4) viscosity index improvers, (5) pour point depressants, and (6) antifouling agents.

  1. 42 CFR 68.16 - Additional conditions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.16 Additional conditions. (a) When a shortage of funds exists, participants may be funded only partially, as determined by the NIH. However, once an NIH LRP contract has been signed by both parties, the NIH will obligate such funds...

  2. 42 CFR 68.16 - Additional conditions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.16 Additional conditions. (a) When a shortage of funds exists, participants may be funded only partially, as determined by the NIH. However, once an NIH LRP contract has been signed by both parties, the NIH will obligate such funds...

  3. 15 CFR 270.204 - Provision of additional resources and services needed by a Team.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Provision of additional resources and services needed by a Team. 270.204 Section 270.204 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NATIONAL CONSTRUCTION SAFETY TEAMS...

  4. NIH Precision Medicine Initiative | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. Feature: NIH Precision Medicine Initiative NIH Precision Medicine Initiative Past Issues / Fall 2015 Table of Contents Connections to Precision Medicine Precision medicine is already saving lives. Read the ...

  5. NIH Quickfinder | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370-2943 National Institute on Deafness and Other Communication Disorders (NIDCD) www.nidcd.nih.gov 1-800- ...

  6. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... fic.nih.gov National Center for Complementary and Alternative Medicine (NCCAM) www.nccam.nih.gov 1-888-644- ... Institute Chris Thomsen , National Center for Complementary and Alternative Medicine Larry Thompson , National Human Genome Research Institute Anne ...

  7. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... nih.gov (301) 443-1124 National Institute of Environmental Health Sciences (NIEHS) www.niehs.nih.gov (919) 541-3345 ... Public Liaison, NIH Christine Bruske , National Institute of Environmental Health Sciences Vicky Cahan , National Institute on Aging Kym Collins- ...

  8. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370-2943 National Institute on Deafness and Other Communication Disorders (NIDCD) www.nidcd.nih.gov 1-800- ...

  9. NIH Research to Results

    MedlinePlus

    ... Past Issues Special Section: Focus on Communication NIH Research to Results Past Issues / Fall 2008 Table of Contents For an enhanced version of this page please turn Javascript on. NIDCD-funded researchers from ... An NIDCD-funded research team says it might be possible in the ...

  10. NIH Research to Results

    MedlinePlus

    ... Current Issue Past Issues Sexually Transmitted Diseases NIH Research to Results Past Issues / Fall 2008 Table of Contents For an enhanced version of this page please turn Javascript on. Testing very young babies ... according to recent research funded by the National Institute of Allergy and ...

  11. Resources

    MedlinePlus

    ... palate - resources Colon cancer - resources Cystic fibrosis - resources Depression - resources Diabetes - resources Digestive disease - resources Drug abuse - resources Eating disorders - resources Elder care - resources Epilepsy - resources Family troubles - ...

  12. Resources allocation in healthcare for cancer: a case study using generalised additive mixed models.

    PubMed

    Musio, Monica; Sauleau, Erik A; Augustin, Nicole H

    2012-11-01

    Our aim is to develop a method for helping resources re-allocation in healthcare linked to cancer, in order to replan the allocation of providers. Ageing of the population has a considerable impact on the use of health resources because aged people require more specialised medical care due notably to cancer. We propose a method useful to monitor changes of cancer incidence in space and time taking into account two age categories, according to healthcar general organisation. We use generalised additive mixed models with a Poisson response, according to the methodology presented in Wood, Generalised additive models: an introduction with R. Chapman and Hall/CRC, 2006. Besides one-dimensional smooth functions accounting for non-linear effects of covariates, the space-time interaction can be modelled using scale invariant smoothers. Incidence data collected by a general cancer registry between 1992 and 2007 in a specific area of France is studied. Our best model exhibits a strong increase of the incidence of cancer along time and an obvious spatial pattern for people more than 70 years with a higher incidence in the central band of the region. This is a strong argument for re-allocating resources for old people cancer care in this sub-region. PMID:23242683

  13. NIH Peer Review

    PubMed Central

    Vancea, Adrian; Chen, Mei-Ching; Chacko, George

    2015-01-01

    The National Institutes of Health (NIH) is the largest source of funding for biomedical research in the world. Funding decisions are made largely based on the outcome of a peer review process that is intended to provide a fair, equitable, timely, and unbiased review of the quality, scientific merit, and potential impact of the research. There have been concerns about the criteria reviewers are using, and recent changes in review procedures at the NIH now make it possible to conduct an analysis of how reviewers evaluate applications for funding. This study examined the criteria and overall impact scores recorded by assigned reviewers for R01 grant applications. The results suggest that all the scored review criteria, including innovation, are related to the overall impact score. Further, good scores are necessary on all five scored review criteria, not just the score for research methodology, in order to achieve a good overall impact score. PMID:27239158

  14. Resources

    MedlinePlus

    ... Diabetes - resources Digestive disease - resources Drug abuse - resources Eating disorders - resources Elder care - resources Epilepsy - resources Family troubles - resources Gastrointestinal disorders - resources Hearing impairment - resources ...

  15. Incrementality and additionality: A new dimension to North-South resource transfers

    SciTech Connect

    Jordan, A. . School of Environmental Sciences); Werksman, J. . Foundation for International Environmental Law and Development)

    1994-06-01

    In the last four years, incrementality'' and additionality'' have emerged as new terms in the evolving lexicon of international environmental diplomacy. As Parties to the Conventions on Climate Change, Biodiversity and the Ozone Layer, industrialized states undertake to provide sufficient additional resources (the principle of additionality) to meet the incremental cost (the concept of incrementality) of measures undertaken by the developing countries to tackle global environmental problems. Issues of incrementality and additionality go to the heart of a much deeper and highly contentious debate on who should pay the costs of responding to global environmental problems; on how the payment should be made; on which agency or agencies should manage the transfers; and upon which parties should be compensated. Every sign is that if the overall North to South transfer breaks down or is retarded, then the process of implementing the aforementioned agreements may be jeopardized. This paper reviews the emergency of the two terms in international environmental politics; it pinpoints the theoretical and practical difficulties of defining and implementing them; and it assesses whether these difficulties and conflicts of opinion may, in some manner, be resolved.

  16. Hemophilia - resources

    MedlinePlus

    Resources - hemophilia ... The following organizations provide further information on hemophilia : Centers for Disease Control and Prevention -- www.cdc.gov/ncbddd/hemophilia/index.html National Heart, Lung, and Blood Institute -- www.nhlbi.nih.gov/ ...

  17. NIH Quickfinder | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 1770 NIH MedlinePlus Advisory Group Marin P. Allen, Ph.D., Office of Communications and Public Liaison, NIH ... of Allergy and Infectious Diseases Richard E. Manrow, Ph.D., National Cancer Institute John McGrath, Ph.D., ...

  18. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... call or go online as noted below: Institutes National Library of Medicine (NLM) www.nlm.nih.gov 1-888-FIND- ... of Communications and Public Liaison, NIH Joyce Backus, National Library of Medicine (ex-officio) Christine Bruske, National Institute of Environmental ...

  19. Healthlines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... NIH researchers report promising results in prevention and treatment of Ebola virus disease (from left) NIH Director Dr. Francis Collins, NIAID Director Dr. Anthony Fauci, and NIH Clinical Center Director Dr. John Gallin exit the Clinical Center ...

  20. NIH Researchers Identify OCD Risk Gene

    MedlinePlus

    ... Home Current Issue Past Issues Research News From NIH NIH Researchers Identify OCD Risk Gene Past Issues / Summer ... page please turn Javascript on. Scientists at the NIH's National Institute on Alcohol Abuse and Alcoholism (NIAAA) ...

  1. Doing business with the NIH

    PubMed Central

    Ben-Menachem, Gil; Ferguson, Steven M; Balakrishnan, Krishna

    2009-01-01

    Young biotech startups can benefit hugely from the US National Institutes of Health (NIH), not least because of the agency's non-dilutive funding, guidance, and opportunities for collaboration. Increasingly, however, there is a fair bit of misunderstanding about what the NIH can and cannot do for a biotech entrepreneur. PMID:16475248

  2. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... nih.gov (301) 443-1124 National Institute of Environmental Health Sciences (NIEHS) www.niehs.nih.gov (919) 541-3345 ... Medicine (ex-officio) Christine Bruske, National Institute of Environmental Health Sciences Vicky Cahan, National Institute on Aging Kym Collins- ...

  3. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 301) 46-0357 Office of Behavioral and Social Sciences Research (OBSSR) http://obssr.od.nih.gov (301) 402-1146 Office of Rare Diseases Research (ORDR) National Center for Advancing Translational Sciences (NCATS) http://rarediseases.info.nih.gov Genetic and ...

  4. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH Medlineplus the Magazine

    MedlinePlus

    ... gov (301) 496-0357 Office of Behavioral and Social Sciences Research (OBSSR) http://obssr.od.nih.gov (301) 402-1146 Office of Rare Diseases Research (ORDR) http://rarediseases.info.nih.gov Genetic and Rare Disease Information Center 1-888-205- ...

  5. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... call or go online as noted below: Institutes National Library of Medicine (NLM) www.nlm.nih.gov 1-888-FIND- ... of Communications and Public Liaison, NIH Joyce Backus, National Library of Medicine (ex-officio) Karina Boehm, National Institute of Dental ...

  6. NIH Quickfinder | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Liaison, NIH Diane Striar, National Heart, Lung, and Blood Institute Chris Thomsen, National Center for Complementary and Alternative Medicine Larry Thompson, National Human Genome Research Institute Anne Thurn, Ph.D., Office of Dietary Supplements Summer 2011 Issue: ...

  7. NIH Quickfinder | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 301) 46-0357 Office of Behavioral and Social Sciences Research (OBSSR) http://obssr.od.nih.gov (301) 402- ... officio) Christine Bruske, National Institute of Environmental Health Sciences ... Research Mary Beth Kester, National Institute of Biomedical Imaging ...

  8. NIH Quickfinder | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 226-4267) National Institute of Biological Imaging and Bioengineering (NIBIB) www.nibib.nih.gov (301) 451-6772 ... Beth Kester, National Institute of Biomedical Imaging and Bioengineering Kathy Kranzfelder, National Institute of Diabetes and Digestive ...

  9. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... 451-6772 National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370- ... Ph.D. , National Institute of Child Health and Human Development Gregory Roa , National Institute of Alcohol Abuse and ...

  10. NIH Quickfinder | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370- ... Ph.D., National Institute of Child Health and Human Development Naomi Miller, National Library of Medicine (ex-officio) ...

  11. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... 451-6772 National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370- ... Ph.D. , National Institute of Child Health and Human Development Gregory Roa , National Institute on Alcohol Abuse and ...

  12. Latest NIH Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: Quit Smoking Latest NIH Research Past Issues / Winter 2011 Table of Contents Many factors contribute to a person's learning to smoke, continuing to smoke, and having difficulty ...

  13. NIH Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Memory & Forgetfulness NIH Research Past Issues / Summer 2013 Table ... agency for research on Alzheimer's disease and related memory research. An analysis funded by the NIA finds ...

  14. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... Ph.D. , National Institute of Child Health and Human Development Gregory Roa , National Institute of Alcohol Abuse and Alcoholism Dennis Rodrigues , Office of Communications and Public Liaison, NIH Chris Thomsen , National Center ...

  15. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... Ph.D. , National Institute of Child Health and Human Development Gregory Roa , National Institute of Alcohol Abuse and Alcoholism Dennis Rodrigues , Office of Communications and Public Liaison, NIH Diane Striar , National Heart, ...

  16. NIH Quickfinder and NIH MedlinePlus Advisory Group

    MedlinePlus

    ... Ph.D. , National Institute of Child Health and Human Development Gregory Roa , National Institute on Alcohol Abuse and Alcoholism Dennis Rodrigues , Office of Communications and Public Liaison, NIH Chris Thomsen , National Center ...

  17. Memory and Forgetfulness: NIH Research

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Memory & Forgetfulness NIH Research Past Issues / Summer 2013 Table ... agency for research on Alzheimer's disease and related memory research. An analysis funded by the NIA finds ...

  18. Basic Science and The NIH

    PubMed Central

    Varmus, Harold

    1994-01-01

    The following is an edited version of the Keynote Speech delivered at the Annual Meeting of the American Society for Cell Biology by Harold Varmus, Director of the National Institutes of Health. The address, entitled Basic Science and the NIH, was given at the opening of the meeting in New Orleans on December 11, 1993. It was Varmus' first public policy talk as NIH Director. PMID:8049519

  19. NIH Funding for Biomedical Imaging

    NASA Astrophysics Data System (ADS)

    Conroy, Richard

    Biomedical imaging, and in particular MRI and CT, is often identified as among the top 10 most significant advances in healthcare in the 20th century. This presentation will describe some of the recent advances in medical physics and imaging being funded by NIH in this century and current funding opportunities. The presentation will also highlight the role of multidisciplinary research in bringing concepts from the physical sciences and applying them to challenges in biological and biomedical research.. NIH Funding for Biomedical Imaging.

  20. Muscular dystrophy - resources

    MedlinePlus

    Resources - muscular dystrophy ... The following organizations are good resources for information on muscular dystrophy : Muscular Dystrophy Association -- www.mdausa.org National Institute of Neurological Disorders and Stroke -- www.ninds.nih. ...

  1. Lung disease - resources

    MedlinePlus

    Resources - lung disease ... The following organizations are good resources for information on lung disease : American Lung Association -- www.lung.org National Heart, Lung, and Blood Institute -- www.nhlbi.nih.gov ...

  2. Spinal injury - resources

    MedlinePlus

    Resources - spinal injury ... The following organizations are good resources for information on spinal injury : National Institute of Neurological Disorders and Stroke -- www.ninds.nih.gov The National Spinal Cord Injury ...

  3. Kidney disease - resources

    MedlinePlus

    Resources - kidney disease ... The following organizations are good resources for information on kidney disease: National Kidney Disease Education Program -- www.nkdep.nih.gov National Kidney Foundation -- www.kidney.org National ...

  4. Cerebral palsy - resources

    MedlinePlus

    Resources - cerebral palsy ... The following organizations are good resources for information on cerebral palsy : National Institute of Neurological Disorders and Stroke -- www.ninds.nih.gov/disorders/cerebral_palsy/cerebral_palsy. ...

  5. Seasonal Allergy Research at NIH | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn Javascript on. Feature: Managing Allergies Seasonal Allergy Research at NIH Past Issues / Summer 2011 Table ... www.nlm.nih.gov/medlineplus/allergy.html MedlinePlus: Hay Fever www.nlm.nih.gov/medlineplus/hayfever.html National ...

  6. Seasonal Allergy Research at NIH | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn Javascript on. Feature: Managing Allergies Seasonal Allergy Research at NIH Past Issues / Spring 2013 Table ... www.nlm.nih.gov/medlineplus/allergy.html MedlinePlus: Hay Fever www.nlm.nih.gov/medlineplus/hayfever.html National ...

  7. NIH Research Radio” Podcasts | NIH MedlinePlus the Magazine

    MedlinePlus

    ... version of this page please turn Javascript on. “NIH Research Radio” Podcasts Past Issues / Winter 2012 Table of Contents Tune in to NIH for Health! NIH: The World’s Leader in Biomedical ...

  8. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 22NIAMS (1-877-226-4267) National Institute of Biomedical Imaging and Bioengineering (NIBIB) www.nibib.nih.gov ( ... National Cancer Institute Thomas Johnson, National Institute of Biomedical Imaging and Bioengineering Kathy Kranzfelder, National Institute of ...

  9. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 226-4267) National Institute of Biomedical Imaging and Bioengineering (NIBIB) www.nibib.nih.gov (301) 451-6772 ... Thomas Johnson, National Institute of Biomedical Imaging and Bioengineering Kathy Kranzfelder, National Institute of Diabetes and Digestive ...

  10. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 226-4267) National Institute of Biomedical Imaging and Bioengineering (NIBIB) www.nibib.nih.gov (301) 451-6772 ... Raymond MacDougall, National Institute of Biomedical Imaging and Bioengineering John Ohab, National Human Genome Research Institute Stephanie ...

  11. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370- ... Ph.D., National Institute of Child Health and Human Development Naomi Miller, National Library of Medicine (ex-officio) ...

  12. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... gov (301) 402-0911 National Institute on Aging (NIA) www.nia.nih.gov Aging information 1-800-222-2225 ... Content Strategist, National Institute of Mental Health Fall 2015 Issue: Volume 10 Number 3 Page 29

  13. "Bionic Man" Showcases Medical Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... For more info, videos, and other resources on biotechnology and medical imaging, visit www.nibib.nih.gov " ... web tool showcasing the latest research advances in biotechnology. It features fourteen technologies being developed by NIBIB- ...

  14. Analysis of the effects of section 29 tax credits on reserve additions and production of gas from unconventional resources

    SciTech Connect

    Not Available

    1990-09-01

    Federal tax credits for production of natural gas from unconventional resources can stimulate drilling and reserves additions at a relatively low cost to the Treasury. This report presents the results of an analysis of the effects of a proposed extension of the Section 29 alternative fuels production credit specifically for unconventional gas. ICF Resources estimated the net effect of the extension of the credit (the difference between development activity expected with the extension of the credit and that expected if the credit expires in December 1990 as scheduled). The analysis addressed the effect of tax credits on project economics and capital formation, drilling and reserve additions, production, impact on the US and regional economies, and the net public sector costs and incremental revenues. The analysis was based on explicit modeling of the three dominant unconventional gas resources: Tight sands, coalbed methane, and Devonian shales. It incorporated the most current data on resource size, typical well recoveries and economics, and anticipated activity of the major producers. Each resource was further disaggregated for analysis based on distinct resource characteristics, development practices, regional economics, and historical development patterns.

  15. Education for Homeless Adults: Strategies for Implementation. Volume II - Resources and Additional Lessons.

    ERIC Educational Resources Information Center

    Hudson River Center for Program Development, Glenmont, NY.

    This document, the second in a series of guidebooks that were developed for educators of homeless adults in New York, offers strategies and plans for sample lessons in which a holistic approach is used to help homeless adults and families improve their lives through education. The guidebook begins with lists of print and nonprint resources,…

  16. Thermal modeling of NiH2 batteries

    NASA Technical Reports Server (NTRS)

    Ponthus, Agnes-Marie; Alexandre, Alain

    1994-01-01

    The following are discussed: NiH2 battery mission and environment; NiH2 cell heat dissipation; Nodal software; model development general philosophy; NiH2 battery model development; and NiH2 experimental developments.

  17. Healthlines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... report promising results in prevention and treatment of Ebola virus disease (from left) NIH Director Dr. Francis ... Gallin exit the Clinical Center with recently discharged Ebola patient Nina Pham (next to Dr. Fauci). NIH's ...

  18. Back Cover: NIH MedlinePlus Salud

    MedlinePlus

    ... Bar Home Current Issue Past Issues NIH MedlinePlus Salud Past Issues / Winter 2009 Table of Contents For ... this page please turn Javascript on. ¡A su salud! Los Institutos Nacionales de la Salud (NIH, por ...

  19. Healthlines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... html. Photo courtesy of NIH From DNA to Beer: A Unique Look at the Mighty Microbe A ... consume. The exhibition is called From DNA to Beer: Harnessing Nature in Medicine and Industry. NIH's National ...

  20. NIH Clinical Research Trials and You

    MedlinePlus

    ... Act News & Events News Releases Videos Images Events Social Media & Outreach More » Quick Links NIH News in Health ... with Us Contact Us Bookmark & Share Email Updates Social Media & Outreach Twitter Facebook YouTube Footer NIH Home En ...

  1. NIH Researchers Identify OCD Risk Gene

    MedlinePlus

    ... News From NIH NIH Researchers Identify OCD Risk Gene Past Issues / Summer 2006 Table of Contents For ... and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive- ...

  2. Back Cover: NIH MedlinePlus Salud

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues NIH MedlinePlus Salud Past Issues / Winter 2009 Table of ... su salud! Los Institutos Nacionales de la Salud (NIH, por sus siglas en inglés), la Sociedad de ...

  3. Teaching English as an Additional Language 5-11: A Whole School Resource File

    ERIC Educational Resources Information Center

    Scott, Caroline

    2011-01-01

    There are increasing numbers of children with little or no English entering English speaking mainstream lessons. This often leaves them with unique frustrations due to limited English language proficiency and disorientation. Teachers often feel unable to cater sufficiently for these new arrivals. "Teaching English as an Additional Language Ages…

  4. NIH Quickfinder and NIH Medline Plus Advisory Group | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 301) 496-0357 Office of Behavioral and Social Sciences Research (OBSSR) obssr.od.nih.gov (301) 402-1146 ... Karina Boehm, National Institute of Dental and Craniofacial Research Christine Bruske, National Institute of Environmental Health Sciences Vicky Cahan, National Institute on Aging Kym Collins- ...

  5. Myasthenia gravis - resources

    MedlinePlus

    Resources - myasthenia gravis ... The following organizations provide information on myasthenia gravis : Myasthenia Gravis Foundation of America -- www.myasthenia.org National Institute of Neurological Disorders and Stroke -- www.ninds.nih.gov/disorders/myasthenia_ ...

  6. Elder care - resources

    MedlinePlus

    The following organizations are good resources for information on aging and elder care: Administration on Aging -- www.aoa.gov Eldercare Locator -- www.eldercare.gov National Institute on Aging -- www.nia.nih.gov

  7. The diffusion tensor imaging (DTI) component of the NIH MRI study of normal brain development (PedsDTI).

    PubMed

    Walker, Lindsay; Chang, Lin-Ching; Nayak, Amritha; Irfanoglu, M Okan; Botteron, Kelly N; McCracken, James; McKinstry, Robert C; Rivkin, Michael J; Wang, Dah-Jyuu; Rumsey, Judith; Pierpaoli, Carlo

    2016-01-01

    The NIH MRI Study of normal brain development sought to characterize typical brain development in a population of infants, toddlers, children and adolescents/young adults, covering the socio-economic and ethnic diversity of the population of the United States. The study began in 1999 with data collection commencing in 2001 and concluding in 2007. The study was designed with the final goal of providing a controlled-access database; open to qualified researchers and clinicians, which could serve as a powerful tool for elucidating typical brain development and identifying deviations associated with brain-based disorders and diseases, and as a resource for developing computational methods and image processing tools. This paper focuses on the DTI component of the NIH MRI study of normal brain development. In this work, we describe the DTI data acquisition protocols, data processing steps, quality assessment procedures, and data included in the database, along with database access requirements. For more details, visit http://www.pediatricmri.nih.gov. This longitudinal DTI dataset includes raw and processed diffusion data from 498 low resolution (3 mm) DTI datasets from 274 unique subjects, and 193 high resolution (2.5 mm) DTI datasets from 152 unique subjects. Subjects range in age from 10 days (from date of birth) through 22 years. Additionally, a set of age-specific DTI templates are included. This forms one component of the larger NIH MRI study of normal brain development which also includes T1-, T2-, proton density-weighted, and proton magnetic resonance spectroscopy (MRS) imaging data, and demographic, clinical and behavioral data. PMID:26048622

  8. NIH Roadmap & the Common Fund - Cancer Imaging Program

    Cancer.gov

    The NIH Roadmap for Medical Research is a series of high impact, trans-NIH programs supported by the NIH Common Fund. These programs address challenges that are priorities for the NIH and medical research but are issues that require the cooperation of more than one NIH institute to address.

  9. NIH Research on Treating Pain | NIH MedlinePlus the Magazine

    MedlinePlus

    ... the NIH Clinical Center. The NIH Pain and Palliative Care Service conducts studies in pain and symptom management, quality of life, complementary therapies, and palliative medicine outcomes. Hospice care is end-of-life ...

  10. NIH Research Addresses Aging Issues and Disparities in Oral Health | NIH MedlinePlus the Magazine

    MedlinePlus

    ... JavaScript on. Feature: Oral Health and Aging NIH Research Addresses Aging Issues and Disparities in Oral Health ... NIH Why is it important to have a research focus on older adults? One reason is that ...

  11. Asthma: NIH-Sponsored Research and Clinical Trials | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Asthma Asthma: NIH-Sponsored Research and Clinical Trials Past Issues / Fall 2011 Table of Contents NIH-Sponsored Research Asthma in the Inner City: Recognizing that asthma severity ...

  12. 10 New NIH Research Highlights | NIH MedlinePlus the Magazine

    MedlinePlus

    ... turn JavaScript on. Feature: NIH Research Update 10 New NIH Research Highlights Spring 2016 Table of Contents ... Tumor Test May Help Women Avoid Chemotherapy A new test may help some women diagnosed with early- ...

  13. NIH Research on Concussion and the Brain | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Feature: Concussion NIH Research on Concussion and the Brain Past Issues / Summer 2015 Table of Contents Dr. ... chronic traumatic encephalopathy (CTE). "Boxing, Football and the Brain" One study, funded in part by NIH, is ...

  14. From the NIH Director: The Importance of Clinical Trials | NIH MedlinePlus the Magazine

    MedlinePlus

    ... on. From the NIH Director: The Importance of Clinical Trials Past Issues / Summer 2011 Table of Contents NIH ... early June to attendees of a 2011 conference, “Clinical Trials: New Challenges and Opportunities,” cosponsored by the National ...

  15. NIH Research Radio” Podcasts | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. “NIH Research Radio” Podcasts Past Issues / Winter 2012 Table of Contents ... Biomedical Research and Information www.nih.gov/news/radio/nihpodcast.htm Brought to you by the National ...

  16. The Children's Inn at NIH Anniversary Key Messages | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: The Children's Inn The Children's Inn at NIH Past Issues / Summer 2014 ... Contents Anniversary Key Messages Playground and Park at The Children's Inn at NIH. Photo courtesy of Mahan ...

  17. NIH Research on Concussion and the Brain | NIH MedlinePlus the Magazine

    MedlinePlus

    ... on. Feature: Concussion NIH Research on Concussion and the Brain Past Issues / Summer 2015 Table of Contents ... called chronic traumatic encephalopathy (CTE). "Boxing, Football and the Brain" One study, funded in part by NIH, ...

  18. 10 New NIH Research Highlights | NIH MedlinePlus the Magazine

    MedlinePlus

    ... turn JavaScript on. Feature: NIH Research Update 10 New NIH Research Highlights Past Issues / Spring 2016 Table ... Tumor Test May Help Women Avoid Chemotherapy A new test may help some women diagnosed with early- ...

  19. Web resources for model organism studies.

    PubMed

    Tang, Bixia; Wang, Yanqing; Zhu, Junwei; Zhao, Wenming

    2015-02-01

    An ever-growing number of resources on model organisms have emerged with the continued development of sequencing technologies. In this paper, we review 13 databases of model organisms, most of which are reported by the National Institutes of Health of the United States (NIH; http://www.nih.gov/science/models/). We provide a brief description for each database, as well as detail its data source and types, functions, tools, and availability of access. In addition, we also provide a quality assessment about these databases. Significantly, the organism databases instituted in the early 1990s--such as the Mouse Genome Database (MGD), Saccharomyces Genome Database (SGD), and FlyBase--have developed into what are now comprehensive, core authority resources. Furthermore, all of the databases mentioned here update continually according to user feedback and with advancing technologies. PMID:25707592

  20. The NIH Countermeasures Against Chemical Threats Program: overview and special challenges.

    PubMed

    Jett, David A

    2016-06-01

    Intentional exposures to toxic chemicals can stem from terrorist attacks, such as the release of sarin in the Tokyo subway system in 1995, as well as from toxic industrial accidents that are much more common. Developing effective medical interventions is a critical component of the overall strategy to overcome the challenges of chemical emergencies. These challenges include the rapid and lethal mode of action of many toxic chemicals that require equally fast-acting therapies, the large number of chemicals that are considered threats, and the diverse demographics and vulnerabilities of those who may be affected. In addition, there may be long-term deleterious effects in survivors of a chemical exposure. Several U.S. federal agencies are invested in efforts to improve preparedness and response capabilities during and after chemical emergencies. For example, the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) Program supports investigators who are developing therapeutics to reduce mortality and morbidity from chemical exposures. The program awards grants to individual laboratories and includes contract resource facilities and interagency agreements with Department of Defense laboratories. The range of high-quality research within the NIH CounterACT Program network is discussed. PMID:27398820

  1. Estimating the NIH Efficient Frontier

    PubMed Central

    2012-01-01

    Background The National Institutes of Health (NIH) is among the world’s largest investors in biomedical research, with a mandate to: “…lengthen life, and reduce the burdens of illness and disability.” Its funding decisions have been criticized as insufficiently focused on disease burden. We hypothesize that modern portfolio theory can create a closer link between basic research and outcome, and offer insight into basic-science related improvements in public health. We propose portfolio theory as a systematic framework for making biomedical funding allocation decisions–one that is directly tied to the risk/reward trade-off of burden-of-disease outcomes. Methods and Findings Using data from 1965 to 2007, we provide estimates of the NIH “efficient frontier”, the set of funding allocations across 7 groups of disease-oriented NIH institutes that yield the greatest expected return on investment for a given level of risk, where return on investment is measured by subsequent impact on U.S. years of life lost (YLL). The results suggest that NIH may be actively managing its research risk, given that the volatility of its current allocation is 17% less than that of an equal-allocation portfolio with similar expected returns. The estimated efficient frontier suggests that further improvements in expected return (89% to 119% vs. current) or reduction in risk (22% to 35% vs. current) are available holding risk or expected return, respectively, constant, and that 28% to 89% greater decrease in average years-of-life-lost per unit risk may be achievable. However, these results also reflect the imprecision of YLL as a measure of disease burden, the noisy statistical link between basic research and YLL, and other known limitations of portfolio theory itself. Conclusions Our analysis is intended to serve as a proof-of-concept and starting point for applying quantitative methods to allocating biomedical research funding that are objective, systematic, transparent

  2. The NIH Extracellular RNA Communication Consortium

    PubMed Central

    Ainsztein, Alexandra M.; Brooks, Philip J.; Dugan, Vivien G.; Ganguly, Aniruddha; Guo, Max; Howcroft, T. Kevin; Kelley, Christine A.; Kuo, Lillian S.; Labosky, Patricia A.; Lenzi, Rebecca; McKie, George A.; Mohla, Suresh; Procaccini, Dena; Reilly, Matthew; Satterlee, John S.; Srinivas, Pothur R.; Church, Elizabeth Stansell; Sutherland, Margaret; Tagle, Danilo A.; Tucker, Jessica M.; Venkatachalam, Sundar

    2015-01-01

    The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena. The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies. The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies, (c) identifying exRNA biomarkers of disease, (d) demonstrating clinical utility of exRNAs as therapeutic agents and developing scalable technologies required for these studies, and (e) developing a community resource, the exRNA Atlas, to provide the scientific community access to exRNA data, standardized exRNA protocols, and other useful tools and technologies generated by funded investigators. PMID:26320938

  3. NIH Quickfinder and NIH MedlinePlus Advisory Group - Fall 2010 | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 1770 NIH MedlinePlus Advisory Group Marin P. Allen, Ph.D., Office of Communications and Public Liaison, NIH ... of Allergy and Infectious Diseases Richard E. Manrow, Ph.D., National Cancer Institute John McGrath, Ph.D., ...

  4. NIH Quickfinder and NIH MedlinePlus Advisory Group - Winter 2010 | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 1770 NIH MedlinePlus Advisory Group Marin P. Allen, Ph.D., Office of Communications and Public Liaison, NIH ... of Allergy and Infectious Diseases Richard E. Manrow, Ph.D., National Cancer Institute John McGrath, Ph.D., ...

  5. Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine

    MedlinePlus

    ... Issues Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine Past Issues / Winter 2007 Table of Contents For ... Javascript on. Among those attending the NIH MedlinePlus magazine launch on Capitol Hill were (l-r) NIH ...

  6. NIH Clinical Center: There’s No Other Hospital Like It | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 000 patients since the hospital opened in 1953. Photo: NIH Clinical Center Home to the NIH Undiagnosed ... basic and clinical science to advance medical knowledge. Photo: NIH Clinical Center History of Medical Milestones At ...

  7. NIH Research: Children Research Volunteers Receive Care and Help Advance Knowledge | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. NIH Research: Children Research Volunteers Receive Care and Help Advance Knowledge Past ... NIH Clinical Center. Photo: NIH Clinical Center Children research volunteers receive care and help advance knowledge I ...

  8. Latest Research from NIH's National Institute of Dental and Craniofacial Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Health Latest Research from NIH's National Institute of Dental and Craniofacial Research Past Issues / Summer 2012 Table ... D., is director of NIH's National Institute of Dental and Craniofacial Research (NIDCR). The NIH's National Institute ...

  9. NIH Quickfinder and NIH MedlinePlus Advisory Group - Spring - Summer 2010 | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Current Issue Past Issues NIH Quickfinder Past Issues / Spring - Summer 2010 Table of Contents For more information ... Institute of Arthritis and Musculoskeletal and Skin Diseases Spring / Summer 2010 Issue: Volume 5 Number 2 Page ...

  10. NIH Quickfinder and NIH MedlinePlus Advisory Group - Fall 2010 | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370- ... Ph.D., National Institute of Child Health and Human Development Naomi Miller, National Library of Medicine (ex-officio) ...

  11. NIH Quickfinder and NIH MedlinePlus Advisory Group - Winter 2010 | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370- ... Ph.D., National Institute of Child Health and Human Development Naomi Miller, National Library of Medicine (ex-officio) ...

  12. Welcome to NIH MedlinePlus magazine!

    MedlinePlus

    ... Current Issue Past Issues Welcome to NIH MedlinePlus magazine! Past Issues / Winter 2009 Table of Contents For ... Produced by the National Institutes of Health, the magazine and its companion Web site medlineplus.gov are ...

  13. Healthlines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... better socially," said James Griffin, PhD, of the Child Development and Behavior Branch at NIH's Eunice Kennedy Shriver ... interaction research program to support studies relevant to child development, health, and the therapeutic use of animals. A ...

  14. NIH Research Leads to Cervical Cancer Vaccine

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues Sexually Transmitted Diseases NIH Research Leads to Cervical Cancer Vaccine Past ... gov . What's New Community-wide treatment of ... of Allergy and Infectious Diseases (NIAID). The study was conducted in a rural ...

  15. RACE, ETHNICITY, AND NIH RESEARCH AWARDS

    PubMed Central

    Ginther, Donna K.; Schaffer, Walter T.; Schnell, Joshua; Masimore, Beth; Liu, Faye; Haak, Laurel L.; Kington, Raynard

    2012-01-01

    We investigated the association between a U.S. National Institutes of Health (NIH) R01 applicant’s self-identified race or ethnicity and the probability of receiving an award by using data from the NIH IMPAC II grant database, the Thomson Reuters Web of Science, and other sources. Although proposals with strong priority scores were equally likely to be funded regardless of race, we find that Asians are 4 percentage points and black or African-American applicants are 13 percentage points less likely to receive NIH investigator-initiated research funding compared with whites. After controlling for the applicant’s educational background, country of origin, training, previous research awards, publication record, and employer characteristics, we find that black or African-American applicants remain 10 percentage points less likely than whites to be awarded NIH research funding. Our results suggest some leverage points for policy intervention. PMID:21852498

  16. Health Lines | NIH Medlineplus the Magazine

    MedlinePlus

    ... nccam.nih.gov/timetotalk . Remember This: Nutrients in Fish May Boost Memory If you want to stay ... That's a type of fat found in most fish, especially fatty fish like salmon and herring. Researchers ...

  17. NIH Research Leads to Cervical Cancer Vaccine

    MedlinePlus

    ... Issues Sexually Transmitted Diseases NIH Research Leads to Cervical Cancer Vaccine Past Issues / Fall 2008 Table of Contents ... in women, the cause of the majority of cervical cancers. Photo courtesy of Judy Folkenberg, NLM Writer By ...

  18. Health Lines | NIH Medlineplus the Magazine

    MedlinePlus

    ... timetotalk . Remember This: Nutrients in Fish May Boost Memory If you want to stay sharp as you ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Two other NIH Institutes funded the ...

  19. NIH/NSF accelerate biomedical research innovations

    Cancer.gov

    A collaboration between the National Science Foundation and the National Institutes of Health will give NIH-funded researchers training to help them evaluate their scientific discoveries for commercial potential, with the aim of accelerating biomedical in

  20. NIH Seeks Reduction in "Indirect Costs."

    ERIC Educational Resources Information Center

    Culliton, Barbara J.

    1983-01-01

    The National Institute of Health (NIH) is currently seeking a reduction in indirect costs associated with the awarding of research funds. Various issues related to these costs, which are causing tension between university administrators and academic researchers, are discussed. (JN)

  1. Dr. Francis Collins Is New NIH Director

    MedlinePlus

    ... Top genetics researcher led mapping of the human genome. Francis S. Collins, M.D., Ph.D., a physician ... who served as Director of the National Human Genome Research Institute (NHGRI) at NIH from 1993-2008. ...

  2. Healthlines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Fall 2013 Table of Contents A display in "Genome: Unlocking Life's Code" exhibition at the National Museum ... Natural History in Washington, DC. NIH's National Human Genome Research Institute and the Smithsonian Institution developed the ...

  3. Focus on Communication: NIH Research to Results

    MedlinePlus

    ... Current Issue Past Issues Special Section: Focus on Communication NIH Research to Results Past Issues / Fall 2008 ... grew new hair cells. Read More "Focus on Communication" Articles Living with Hearing Loss / Anatomy of the ...

  4. Input on NIH Toolbox inclusion criteria

    PubMed Central

    Victorson, David; Debb, Scott M.; Gershon, Richard C.

    2013-01-01

    Objective: The NIH Toolbox is intended to be responsive to the needs of investigators evaluating neurologic and behavioral function in diverse settings. Early phases of the project involved gathering information and input from potential end users. Methods: Information was collected through literature and instrument database reviews, requests for information, consensus meetings, and expert interviews and integrated into the NIH Toolbox development process in an iterative manner. Results: Criteria for instrument inclusion, subdomains to be assessed, and preferences regarding instrument cost and length were obtained. Existing measures suitable for inclusion in the NIH Toolbox and areas requiring new measure development were identified. Conclusion: The NIH Toolbox was developed with explicit input from potential end users regarding many of its key features. PMID:23479548

  5. Healthlines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... their health." Promising Method for Early Detection of Pancreatic Cancer Nearly 50,000 Americans will be diagnosed with pancreatic cancer in 2015, according to NIH's National Cancer Institute ( ...

  6. 77 FR 27785 - Request for Information Regarding the NIH-Industry Program To Discover New Therapeutic Uses for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... program will focus on discovering new therapeutic uses of existing molecules (Therapeutics Discovery). The... be submitted electronically to Therapeutics.Discovery@nih.gov . For additional information, please... (Therapeutics Discovery). Many discontinued compounds and biologics that have already been tested in...

  7. Aging as an evolvability-increasing program which can be switched off by organism to mobilize additional resources for survival.

    PubMed

    Skulachev, Maxim V; Severin, Fedor F; Skulachev, Vladimir P

    2015-01-01

    During the last decade, several pieces of convincing evidence were published indicating that aging of living organisms is programmed, being a particular case of programmed death of organism (phenoptosis). Among them, the following observations can be mentioned. (1) Species were described that show negligible aging. In mammals, the naked mole rat is the most impressive example. This is a rodent of mouse size living at least 10-fold longer than a mouse and having fecundity higher than a mouse and no agerelated diseases. (2) In some species with high aging rate, genes responsible for active organization of aging by poisoning of the organism with endogenous metabolites have been identified. (3) In women, standard deviations divided by the mean are the same for age of menarche (an event controlled by the ontogenetic program) and for age of menopause (an aging-related event). (4) Inhibitors of programmed cell death (apoptosis and necrosis) retard and in certain cases even reverse the development of age-dependent pathologies. (5) In aging species, the rate of aging is regulated by the individual which responds by changes in this rate to changes in the environmental conditions. In this review, we consider point (5) in detail. Data are summarized suggesting that inhibition of aging rate by moderate food restriction can be explained assuming that such restriction is perceived by the organism as a signal of future starvation. In response to this dramatic signal, the organism switches off such an optional program as aging, mobilizing in such a way additional reserves for survival. A similar explanation is postulated for geroprotective effects of heavy muscle work, a lowering or a rise in the external temperature, small amounts of metabolic poisons (hormesis), low doses of radiation, and other deleterious events. On the contrary, sometimes certain positive signals can prolong life by inhibiting the aging program in individuals who are useful for the community (e

  8. NIH Quickfinder and NIH MedlinePlus Advisory Group - Winter 2011

    MedlinePlus

    ... 1770 NIH MedlinePlus Advisory Group Marin P. Allen, Ph.D., Office of Communications and Public Liaison, NIH ... of Allergy and Infectious Diseases Richard E. Manrow, Ph.D., National Cancer Institute John McGrath, Ph.D., ...

  9. 77 FR 54584 - Final Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... in the Federal Register (74 FR 9411) to revise the NIH Guidelines in two regards. The first was to..., NIH/OBA revised the proposal and published a notice for comment on April 22, 2010 (75 FR 21008...-1, Experiments Involving the Cloning of Toxin Molecules with LD50 of Less Than 100 Nanograms...

  10. Resources.

    ERIC Educational Resources Information Center

    Stewart, John; MacDonald, Ian

    1980-01-01

    Presents a guide to resources on television drama available to teachers for classroom use in television curriculum. Lists American and British television drama videorecordings of both series and individual presentations and offers a bibliography of "one-off" single fiction plays produced for British television. (JMF)

  11. National Survey of Laboratory Animal Facilities and Resources. Fiscal Year 1978.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC. Inst. of Lab. Animal Resources.

    Reported is a national survey of laboratory animal facilities and resources conducted by the Institute of Laboratory Animal Resources (ILAR) at the request of the Animal Resources Program Branch of the NIH Division of Research Resources. Two earlier surveys (1964 and 1970) had been conducted by ILAR at the request of NIH. Since these reports were…

  12. Addition to Transition Assessment Resources: A Template for Determining the Use of Guardianship Alternatives for Students Who Have Intellectual Disability

    ERIC Educational Resources Information Center

    Millar, Dorothy Squatrito

    2014-01-01

    The main purpose of this article is to add to the transition assessment resources by introducing the Guardianship Alternative Assessment Template (GAAT) as it relates to guardianship prevention for youth and adults who have an intellectual disability. Guardianship refers to a legal intervention when a court determines that adult individuals are…

  13. Deep Vein Thrombosis: Symptoms, Diagnosis, Treatment and Latest NIH Research

    MedlinePlus

    ... Vein Thrombosis: Symptoms, Diagnosis, Treatment and Latest NIH Research Past Issues / Spring 2011 Table of Contents Symptoms ... without the monitoring required for warfarin. Latest NIH Research The National Heart, Lung, and Blood Institute (NHLBI) ...

  14. From the NIH Director: A Global Health System

    MedlinePlus

    ... Issue Past Issues From the NIH Director: A Global Health System Past Issues / Spring 2008 Table of ... officials the issues of world health and NIH's global outreach. He spoke with MedlinePlus ' Christopher Klose on ...

  15. Help Stop the Flu | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Health and Human Services (HHS). Latest NIH Flu Research Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and ... research program. NIAID works nationally with academic medical centers ...

  16. In Tribute: Senator Edward M. Kennedy, Friend of NIH

    MedlinePlus

    ... Javascript on. In Tribute: Senator Edward M. Kennedy, Friend of NIH Past Issues / Fall 2009 Table of ... NICHD) in Shriver's honor. Senator Edward M. Kennedy, Friend of NIH "… deep compassion for those in need." ...

  17. Mentoring in Medicine | NIH MedlinePlus the Magazine

    MedlinePlus

    ... http://m.medlineplus.gov/spanish Tune in: NIH Radio Free podcast audio reports on your computer or personal audio player www.nih.gov/news/radio/nihpodcast.htm Summer 2013 Issue: Volume 8 Number ...

  18. NIH-Supported Clinical Trial Finds Antidepressant Reduces Alzheimer's Agitation

    MedlinePlus

    ... Plan National Alzheimer's Project Act (NAPA) About ADEAR NIH-supported clinical trial finds antidepressant reduces Alzheimer’s agitation February 25, 2014 NIH-funded researchers are testing interventions to alleviate psychiatric ...

  19. NIH Research: Children Research Volunteers Receive Care and Help Advance Knowledge | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Center than at any other place in the world,” said Dr. John I. Gallin, NIH Clinical Center ... NIH Clinical Center, children are treated to a world-class staff of specialists and support services. A ...

  20. Subscribe to NIH MedlinePlus the Magazine

    MedlinePlus

    ... turn Javascript on. Subscribe to NIH MedlinePlus the magazine NIH MedlinePlus the magazine is published quarterly, in print and on the ... up for a free subscription to NIH MedlinePlus Magazine. Librarians may order this magazine in bulk . Please ...

  1. Mary Tyler Moore Helps Launch NIH MedlinePlus Magazine

    MedlinePlus

    ... Javascript on. Among those attending the NIH MedlinePlus magazine launch on Capitol Hill were (l-r) NIH Director Dr. Elias Zerhouni, Rep. Ralph Regula (R-OH), Mary Tyler Moore, former Rep. Paul Rogers, and NLM ... issue of NIH MedlinePlus magazine. In September, the FNLM was fortunate to have ...

  2. How to Write an NIH R13 Conference Grant Application

    ERIC Educational Resources Information Center

    Sonis, Jeffrey H.; Triffleman, Elisa; King, Lynda; King, Daniel

    2009-01-01

    Objective: The purpose of this article is to provide recommendations for writing a successful R13 conference grant proposal for the National Institutes of Health (NIH). Methods: The authors reviewed successful NIH conference grant proposal abstracts. They also reflect on their own experience in writing an NIH conference grant proposal and…

  3. 42 CFR 52a.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false How will NIH evaluate applications? 52a.5 Section 52a.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CENTER GRANTS § 52a.5 How will NIH evaluate applications? (a) NIH considers...

  4. 42 CFR 52a.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false How will NIH evaluate applications? 52a.5 Section 52a.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CENTER GRANTS § 52a.5 How will NIH evaluate applications? (a) NIH considers...

  5. 42 CFR 52a.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How will NIH evaluate applications? 52a.5 Section 52a.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CENTER GRANTS § 52a.5 How will NIH evaluate applications? (a) NIH considers...

  6. 42 CFR 52a.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false How will NIH evaluate applications? 52a.5 Section 52a.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CENTER GRANTS § 52a.5 How will NIH evaluate applications? (a) NIH considers...

  7. 42 CFR 52a.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false How will NIH evaluate applications? 52a.5 Section 52a.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CENTER GRANTS § 52a.5 How will NIH evaluate applications? (a) NIH considers...

  8. NIH and NCI grant-related changes during fiscal years 2014 and 2015

    NASA Astrophysics Data System (ADS)

    Wong, Rosemary S. L.

    2015-03-01

    The 2014 fiscal year (FY) continued to be a challenging one for all federal agencies despite the many Congressional strategies proposed to address the U.S. budget deficit. The Bipartisan Budget Act of 2013 passed by the House and Senate in December 2013 approved a two-year spending bill which cancelled the FY2014 and FY2015 required sequestration cuts (i.e., 4-5% National Institute of Health (NIH)/National Cancer Institute (NCI) budget reduction initiated on March 1, 2013), but extended the sequestration period through FY2023. This bill passage helped minimize any further budget reductions and resulted in a final FY2014 NIH budget of 29.9 billion and a NCI budget of 4.9 billion. Both NIH and NCI worked hard to maintain awarding the same number of NIH/NCI investigator-initiated R01 and exploratory R21 grants funded in FY2014 and similar to the level seen in FY2013 and previous years (see Tables 1 and 2). Since Congress only recently passed the 2015 spending bill in December 16, 2014, the final NIH and NCI budget appropriations for FY2015 remains unknown at this time and most likely will be similar to the FY2014 budget level. The NCI overall success and funding rates for unsolicited investigator-initiated R01 applications remained at 15%, while the success rate for exploratory R21 applications was 12% in FY2014 with similar rates seen in FY2013 (see Tables 1 and 2). The success rate for biomedical research applications in the Photodynamic Therapy and laser research field will be provided for the past few years. NIH provides numerous resources to help inform the extramural biomedical research community of new and current grant applicants about new grant policy changes and the grant submission and review processes.

  9. The Children's Inn at NIH Anniversary Key Messages | NIH MedlinePlus the Magazine

    MedlinePlus

    ... through mutual support including therapeutic, recreational, and educational programming. Establishment of The Inn took hard work, dedication ... 7 million for the expansion project. fast facts 1 The Children's Inn, located on the NIH campus ...

  10. NIH Quickfinder and NIH MedlinePlus Advisory Group - Summer 2009

    MedlinePlus

    ... Current Issue Past Issues NIH Quickfinder Past Issues / Summer 2009 Table of Contents For an enhanced version ... Institute of Arthritis and Musculoskeletal and Skin Diseases Summer 2009 Issue: Volume 4 Number 3 Page 29

  11. The NIH Undiagnosed Diseases Program | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Genome Research Institute (NHGRI). The National Institutes of Health (NIH) has been bringing sick people to its ... Inherited Disorder Researchers for the National Institutes of Health’s Undiagnosed Diseases Program (UDP) have pinpointed a genetic ...

  12. NIH Quickfinder and NIH MedlinePlus Advisory Group - Fall 2009

    MedlinePlus

    ... 226-4267) National Institute of Biological Imaging and Bioengineering (NIBIB) www.nibib.nih.gov (301) 451-6772 ... Beth Kester, National Institute of Biomedical Imaging and Bioengineering Kathy Kranzfelder, National Institute of Diabetes and Digestive ...

  13. NIH Quickfinder and NIH MedlinePlus Advisory Group - Winter 2011

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) www.nichd.nih.gov 1-800-370- ... Ph.D., National Institute of Child Health and Human Development Naomi Miller, National Library of Medicine (ex-officio) ...

  14. Deep Vein Thrombosis: Symptoms, Diagnosis, Treatment and Latest NIH Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Deep Vein Thrombosis Deep Vein Thrombosis: Symptoms, Diagnosis, Treatment and Latest NIH ... of Contents Symptoms The signs and symptoms of deep vein thrombosis (DVT) may be related to DVT ...

  15. For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine | NIH ...

    MedlinePlus

    ... turn Javascript on. For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine Past ... hearing from you. The Friends of the National Library of Medicine has a warm and mutually appreciative ...

  16. For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus Magazine | NIH ...

    MedlinePlus

    ... page please turn Javascript on. For Distinguished Public Service: Medical Library Association Honors FNLM and NIH MedlinePlus ... Dr. Donald West King with the Distinguished Public Service Award at the MLA’s recent national conference. Let ...

  17. The Children's Inn at NIH turns 25 | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: The Children's Inn The Children's Inn at NIH turns 25 Past Issues / ... home …" for all families! What to Expect at The Children's Inn The Children's Inn enhances opportunities for ...

  18. The Children's Inn at NIH - Three Stories | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: The Children's Inn The Children's Inn at NIH - Three Stories Past Issues / Summer 2014 Table of Contents Kristal Nemeroff—The Patient Kristal Nemeroff, age 2, at the Children's ...

  19. NIH Research on Treating Pain | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: Chronic Pain NIH Research on Treating Pain Past Issues / Spring 2011 Table of Contents Among ... enhance pain research and promote collaboration among researchers. Pain at End of Life Chronic pain management at ...

  20. Emotion assessment using the NIH Toolbox

    PubMed Central

    Butt, Zeeshan; Pilkonis, Paul A.; Cyranowski, Jill M.; Zill, Nicholas; Hendrie, Hugh C.; Kupst, Mary Jo; Kelly, Morgen A. R.; Bode, Rita K.; Choi, Seung W.; Lai, Jin-Shei; Griffith, James W.; Stoney, Catherine M.; Brouwers, Pim; Knox, Sarah S.; Cella, David

    2013-01-01

    One of the goals of the NIH Toolbox for Assessment of Neurological and Behavioral Function was to identify or develop brief measures of emotion for use in prospective epidemiologic and clinical research. Emotional health has significant links to physical health and exerts a powerful effect on perceptions of life quality. Based on an extensive literature review and expert input, the Emotion team identified 4 central subdomains: Negative Affect, Psychological Well-Being, Stress and Self-Efficacy, and Social Relationships. A subsequent psychometric review identified several existing self-report and proxy measures of these subdomains with measurement characteristics that met the NIH Toolbox criteria. In cases where adequate measures did not exist, robust item banks were developed to assess concepts of interest. A population-weighted sample was recruited by an online survey panel to provide initial item calibration and measure validation data. Participants aged 8 to 85 years completed self-report measures whereas parents/guardians responded for children aged 3 to 12 years. Data were analyzed using a combination of classic test theory and item response theory methods, yielding efficient measures of emotional health concepts. An overview of the development of the NIH Toolbox Emotion battery is presented along with preliminary results. Norming activities led to further refinement of the battery, thus enhancing the robustness of emotional health measurement for researchers using the NIH Toolbox. PMID:23479549

  1. Healthline | NIH MedlinePlus the Magazine

    MedlinePlus

    ... brain activity with a powerful and fast MEG brain imaging scanner. NIH Research Uncovers New Clue to Treating Depression Scientists have made a new discovery in their attempt to find a ... a signal in the brain that may help to identify which patients will ...

  2. Motor assessment using the NIH Toolbox

    PubMed Central

    Magasi, Susan; McCreath, Heather E.; Bohannon, Richard W.; Wang, Ying-Chih; Bubela, Deborah J.; Rymer, William Z.; Beaumont, Jennifer; Rine, Rose Marie; Lai, Jin-Shei; Gershon, Richard C.

    2013-01-01

    Motor function involves complex physiologic processes and requires the integration of multiple systems, including neuromuscular, musculoskeletal, and cardiopulmonary, and neural motor and sensory-perceptual systems. Motor-functional status is indicative of current physical health status, burden of disease, and long-term health outcomes, and is integrally related to daily functioning and quality of life. Given its importance to overall neurologic health and function, motor function was identified as a key domain for inclusion in the NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox). We engaged in a 3-stage developmental process to: 1) identify key subdomains and candidate measures for inclusion in the NIH Toolbox, 2) pretest candidate measures for feasibility across the age span of people aged 3 to 85 years, and 3) validate candidate measures against criterion measures in a sample of healthy individuals aged 3 to 85 years (n = 340). Based on extensive literature review and input from content experts, the 5 subdomains of dexterity, strength, balance, locomotion, and endurance were recommended for inclusion in the NIH Toolbox motor battery. Based on our validation testing, valid and reliable measures that are simultaneously low-cost and portable have been recommended to assess each subdomain, including the 9-hole peg board for dexterity, grip dynamometry for upper-extremity strength, standing balance test, 4-m walk test for gait speed, and a 2-minute walk test for endurance. PMID:23479547

  3. Proposed NIH Budget Includes Mandatory Funding.

    PubMed

    2016-05-01

    President Obama has proposed an overall budget increase of $825 million for the NIH in fiscal year 2017 compared with 2016. That money would be reserved for three efforts: the NCI's "moonshot" initiative, the Precision Medicine Initiative cohort program, and the BRAIN program. PMID:26984350

  4. Norming plans for the NIH Toolbox

    PubMed Central

    Havlik, Richard; Cook, Karon F.; Hays, Ron D.; Wallner-Allen, Kathleen; Korper, Samuel P.; Lai, Jin-Shei; Nord, Christine; Zill, Nicholas; Choi, Seung; Yost, Kathleen J.; Ustsinovich, Vitali; Brouwers, Pim; Hoffman, Howard J.; Gershon, Richard

    2013-01-01

    Objective: The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a comprehensive battery of brief assessment tools. The purpose of this article is to describe plans to establish normative reference values for the NIH Toolbox measures. Methods: A large sample will be obtained from the US population for the purpose of calculating normative values. The sample will be stratified by age (ages 3–85 years), sex, and language preference (English or Spanish) and have a total sample size of at least 4,205. The sample will include a minimum of 25–100 individuals in each targeted demographic and language subgroup. Results: Norming methods will include poststratification adjustment calculated using iterative proportional fitting, also known as raking, so that the weighted sample will have the same distribution on key demographic variables as the US population described in the 2010 Census. Conclusions: As with any set of norms, users should be mindful of the reference population and make conclusions consistent with the limitations of normative sampling, since it is not a probability-based sample. However, the NIH Toolbox norming study has been designed to minimize bias and maximize representativeness and precision of estimates. The availability of a "toolbox" of normed measures will be an important foundation for addressing critical research questions in neurologic and behavioral health. PMID:23479550

  5. Healthlines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... squamous cell carcinoma is usually not life-threatening. Photo courtesy of NIGMS.NIH.GOV A new exhibit gives people a unique look at life. Life: Magnified is a collection of scientific images of blood, bacteria, viruses, and more, enlarged up to 50,000 times. ...

  6. Committee approves bill to boost NIH funding.

    PubMed

    2015-08-01

    A U.S. House of Representatives committee approved the 21st Century Cures Act. If passed by Congress, the bill would boost funding for the NIH and FDA and introduce new strategies for accelerating the approval of drugs and devices. PMID:26116105

  7. Examining the Predictive Validity of NIH Peer Review Scores

    PubMed Central

    Lindner, Mark D.; Nakamura, Richard K.

    2015-01-01

    The predictive validity of peer review at the National Institutes of Health (NIH) has not yet been demonstrated empirically. It might be assumed that the most efficient and expedient test of the predictive validity of NIH peer review would be an examination of the correlation between percentile scores from peer review and bibliometric indices of the publications produced from funded projects. The present study used a large dataset to examine the rationale for such a study, to determine if it would satisfy the requirements for a test of predictive validity. The results show significant restriction of range in the applications selected for funding. Furthermore, those few applications that are funded with slightly worse peer review scores are not selected at random or representative of other applications in the same range. The funding institutes also negotiate with applicants to address issues identified during peer review. Therefore, the peer review scores assigned to the submitted applications, especially for those few funded applications with slightly worse peer review scores, do not reflect the changed and improved projects that are eventually funded. In addition, citation metrics by themselves are not valid or appropriate measures of scientific impact. The use of bibliometric indices on their own to measure scientific impact would likely increase the inefficiencies and problems with replicability already largely attributed to the current over-emphasis on bibliometric indices. Therefore, retrospective analyses of the correlation between percentile scores from peer review and bibliometric indices of the publications resulting from funded grant applications are not valid tests of the predictive validity of peer review at the NIH. PMID:26039440

  8. NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping.

    PubMed

    Laughlin, Maren R; Lloyd, K C Kent; Cline, Gary W; Wasserman, David H

    2012-10-01

    The Mouse Metabolic Phenotyping Centers (MMPCs) were founded in 2001 by the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high-quality phenotyping services for mouse models of diabetes, obesity, and their complications. The intent is to allow researchers to take optimum advantage of the many new mouse models produced in labs and in high-throughput public efforts. The six MMPCs are located at universities around the country and perform complex metabolic tests in intact mice and hormone and analyte assays in tissues on a fee-for-service basis. Testing is subsidized by the NIH in order to reduce the barriers for mouse researchers. Although data derived from these tests belong to the researcher submitting mice or tissues, these data are archived after publication in a public database run by the MMPC Coordinating and Bioinformatics Unit. It is hoped that data from experiments performed in many mouse models of metabolic diseases, using standard protocols, will be useful in understanding the nature of these complex disorders. The current areas of expertise include energy balance and body composition, insulin action and secretion, whole-body and tissue carbohydrate and lipid metabolism, cardiovascular and renal function, and metabolic pathway kinetics. In addition to providing services, the MMPC staff provides expertise and advice to researchers, and works to develop and refine test protocols to best meet the community's needs in light of current scientific developments. Test technology is disseminated by publications and through annual courses. PMID:22940748

  9. Using the NIH Toolbox in special populations

    PubMed Central

    Manly, Jennifer; Wallner-Allen, Kathleen; Fox, Nathan; Purnell, Christy; Hendrie, Hugh; Havlik, Richard; Harniss, Mark; Magasi, Susan; Correia, Helena; Gershon, Richard

    2013-01-01

    Background: In order to develop health outcomes measures that are relevant and applicable to the general population, it is essential to consider the needs and requirements of special subgroups, such as the young, elderly, disabled, and people of different ethnic and cultural backgrounds, within that population. Methods: The NIH Toolbox project convened several working groups to address assessment issues for the following subgroups: pediatric, geriatric, cultural, non–English-speaking, and disabled. Each group reviewed all NIH Toolbox instruments in their entirety. Results: Each working group provided recommendations to the scientific study teams regarding instrument content, presentation, and administration. When feasible and appropriate, instruments and administration procedures have been modified in accordance with these recommendations. Conclusion: Health outcome measurement can benefit from expert input regarding assessment considerations for special subgroups. PMID:23479537

  10. Politicizing NIH funding: a bridge to nowhere

    PubMed Central

    Epstein, Jonathan A.

    2011-01-01

    We live in a time of increased spending, mounting debt, and few remedies for balancing the federal budget that have bipartisan support. Unfortunately, one recent target for decreased allocations of the federal budget is the NIH; the discussion of the awarded grants and the grant funding process has been skewed and altered to present medical research in an unfriendly light, and this can have very damaging repercussions. Politicizing this process could ultimately challenge human health, technology, and economic growth. PMID:21881213

  11. Seeking NIH funding: Defining the process

    NASA Astrophysics Data System (ADS)

    Shekim, Lana

    2003-04-01

    The presentation will provide a brief introduction to the National Institute on Deafness and other Communication Disorders (NIDCD) with emphasis on the Voice and Speech program in the Division of Extramural Research. The process of seeking NIH funding will be outlined and a number of funding mechanisms will be described. The peer review process and the time course of a grant application will be highlighted.

  12. Cognition assessment using the NIH Toolbox

    PubMed Central

    Dikmen, Sureyya S.; Heaton, Robert K.; Tulsky, David S.; Zelazo, Philip D.; Bauer, Patricia J.; Carlozzi, Noelle E.; Slotkin, Jerry; Blitz, David; Wallner-Allen, Kathleen; Fox, Nathan A.; Beaumont, Jennifer L.; Mungas, Dan; Nowinski, Cindy J.; Richler, Jennifer; Deocampo, Joanne A.; Anderson, Jacob E.; Manly, Jennifer J.; Borosh, Beth; Havlik, Richard; Conway, Kevin; Edwards, Emmeline; Freund, Lisa; King, Jonathan W.; Moy, Claudia; Witt, Ellen; Gershon, Richard C.

    2013-01-01

    Cognition is 1 of 4 domains measured by the NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIH-TB), and complements modules testing motor function, sensation, and emotion. On the basis of expert panels, the cognition subdomains identified as most important for health, success in school and work, and independence in daily functioning were Executive Function, Episodic Memory, Language, Processing Speed, Working Memory, and Attention. Seven measures were designed to tap constructs within these subdomains. The instruments were validated in English, in a sample of 476 participants ranging in age from 3 to 85 years, with representation from both sexes, 3 racial/ethnic categories, and 3 levels of education. This report describes the development of the Cognition Battery and presents results on test-retest reliability, age effects on performance, and convergent and discriminant construct validity. The NIH-TB Cognition Battery is intended to serve as a brief, convenient set of measures to supplement other outcome measures in epidemiologic and longitudinal research and clinical trials. With a computerized format and national standardization, this battery will provide a “common currency” among researchers for comparisons across a wide range of studies and populations. PMID:23479546

  13. Cognition assessment using the NIH Toolbox.

    PubMed

    Weintraub, Sandra; Dikmen, Sureyya S; Heaton, Robert K; Tulsky, David S; Zelazo, Philip D; Bauer, Patricia J; Carlozzi, Noelle E; Slotkin, Jerry; Blitz, David; Wallner-Allen, Kathleen; Fox, Nathan A; Beaumont, Jennifer L; Mungas, Dan; Nowinski, Cindy J; Richler, Jennifer; Deocampo, Joanne A; Anderson, Jacob E; Manly, Jennifer J; Borosh, Beth; Havlik, Richard; Conway, Kevin; Edwards, Emmeline; Freund, Lisa; King, Jonathan W; Moy, Claudia; Witt, Ellen; Gershon, Richard C

    2013-03-12

    Cognition is 1 of 4 domains measured by the NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIH-TB), and complements modules testing motor function, sensation, and emotion. On the basis of expert panels, the cognition subdomains identified as most important for health, success in school and work, and independence in daily functioning were Executive Function, Episodic Memory, Language, Processing Speed, Working Memory, and Attention. Seven measures were designed to tap constructs within these subdomains. The instruments were validated in English, in a sample of 476 participants ranging in age from 3 to 85 years, with representation from both sexes, 3 racial/ethnic categories, and 3 levels of education. This report describes the development of the Cognition Battery and presents results on test-retest reliability, age effects on performance, and convergent and discriminant construct validity. The NIH-TB Cognition Battery is intended to serve as a brief, convenient set of measures to supplement other outcome measures in epidemiologic and longitudinal research and clinical trials. With a computerized format and national standardization, this battery will provide a "common currency" among researchers for comparisons across a wide range of studies and populations. PMID:23479546

  14. Gustation assessment using the NIH Toolbox

    PubMed Central

    Mennella, Julie A.; Duffy, Valerie B.; Pelchat, Marcia L.; Griffith, James W.; Smutzer, Gregory; Cowart, Beverly J.; Breslin, Paul A.S.; Bartoshuk, Linda M.; Hastings, Lloyd; Victorson, David; Hoffman, Howard J.

    2013-01-01

    The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a set of brief measures for the assessment of cognitive function, emotional health, motor function, and sensory function for use in clinical trials and in epidemiologic and longitudinal studies. Gustatory perception is assessed as 1 of 6 areas of sensory function. A team of 11 scientists with expertise in taste perception selected 2 gustatory measures, 1 of which can be used in young pediatric populations. The measure selected for young pediatric populations assesses sucrose (sweet) taste preference and can also be used across the age span of 5 to 85 years. For adult populations, the selected measure is a regional test, which assesses variability in perceived intensity of quinine hydrochloride (bitter) when applied to the tongue tip as well as perceived with the whole mouth. The team also recommends the regional test for assessing other tastants, such as sodium chloride (salty). Validation studies have demonstrated that the measures modified for the NIH Toolbox correlate with more traditional assessments, and can identify known population differences in gustation. PMID:23479539

  15. Food Resources of Stream Macronivertebrates Determined by Natural-Abundance stable C and N Isotopes and a 15N Tracer Addition

    SciTech Connect

    Mulholland, P. J.

    2000-01-01

    Trophic relationships were examined using natural-abundance {sup 13}C and {sup 15}N analyses and a {sup 15}N-tracer addition experiment in Walker Branch, a 1st-order forested stream in eastern Tennessee. In the {sup 15}N-tracer addition experiment, we added {sup 15}NH{sub 4} to stream water over a 6-wk period in early spring, and measured {sup 15}N:{sup 14}N ratios in different taxa and biomass compartments over distance and time. Samples collected from a station upstream from the {sup 15}N addition provided data on natural-abundance {sup 13}C:{sup 12}C and {sup 15}N:{sup 14}N ratios. The natural-abundance {sup 15}N analysis proved to be of limited value in identifying food resources of macroinvertebrates because {sup 15}N values were not greatly different among food resources. In general, the natural-abundance stable isotope approach was most useful for determining whether epilithon or detritus were important food resources for organisms that may use both (e.g., the snail Elimia clavaeformis), and to provide corroborative evidence of food resources of taxa for which the {sup 15}N tracer results were not definitive. The {sup 15}N tracer results showed that the mayflies Stenonema spp. and Baetis spp. assimilated primarily epilithon, although Baetis appeared to assimilate a portion of the epilithon (e.g., algal cells) with more rapid N turnover than the bulk pool sampled. Although Elimia did not reach isotopic equilibrium during the tracer experiment, application of a N-turnover model to the field data suggested that it assimilated a combination of epilithon and detritus. The amphipod Gammarus minus appeared to depend mostly on fine benthic organic matter (FBOM), and the coleopteran Anchytarsus bicolor on epixylon. The caddisfly Diplectrona modesta appeared to assimilate primarily a fast N-turnover portion of the FBOM pool, and Simuliidae a fast N-turnover component of the suspended particulate organic matter pool rather than the bulk pool sampled. Together, the

  16. Mineral resources of the Sheep Mountain Wilderness study area and the Cucamonga Wilderness and additions, Los Angeles and San Bernardino counties, California

    USGS Publications Warehouse

    Evans, James G.; Pankraatz, Leroy; Ridenour, James; Schmauch, Steven W.; Zilka, Nicholas T.

    1977-01-01

    A mineral survey of the Sheep Mountain Wilderness study area and Cucamonga Wilderness area and additions by the U.S. Geological Survey and Bureau of Mines in 1975 covered about 66,500 acres (26,500 ha) of the San Bernardino and Angeles National Forests in southern California. The two study areas are separated by San Antonio Canyon. The mineral resource potential was evaluated through geological, geochemical, and geophysical studies by the Geological Survey and through evaluation of mines and prospects by the Bureau of Mines.

  17. Do you have NIH funding? Then read this.

    PubMed

    Neill, Ushma S; Kosht, Karen

    2005-06-01

    In the "Policy on enhancing public access to archived publications resulting from NIH-funded research," the NIH requests that all publications resulting from primary research supported by NIH grants be deposited in PubMed Central (PMC), the online repository of the National Library of Medicine. The NIH requests that all manuscripts accepted for publication after May 2, 2005 be deposited in PMC, and that those manuscripts be made freely available to the public within 12 months of publication. The JCI supports this policy: we will continue to make all content freely available in PMC immediately upon publication, and the entire JCI archive is freely available through PMC. PMID:15931367

  18. Nesting material and number of females per cage: effects on mouse productivity in BALB/c, C57BL/6J, DBA/2 and NIH/S mice.

    PubMed

    Eskola, S; Kaliste-Korhonen, E

    1999-04-01

    Two different materials-aspen wood-wool and paper towel-were compared as nesting material for three inbred mouse strains (BALB/c, C57BL/6J and DBA/2) housed in barrier conditions. In addition, the effect of varying the number of females per cage (one to three per cage) of these three strains and with NIH/S outbred mouse stock was studied. The number of litters, litter size and neonatal mortality were determined, as well as age, sex and weight of weanlings. The type of nesting material did not affect the characteristics monitored. In all strains, the number of weanlings per female was greatest in singly-housed females. In terms of the number of weanlings per cage, two females per cage gave the best result. In DBA/2 mice, neonatal mortality increased when several females were caged together. PMID:10780814

  19. The NIH Undiagnosed Diseases Program | NIH MedlinePlus the Magazine

    MedlinePlus

    ... rare diseases,” says Eric D. Green, M.D., Ph.D., director of the National Human Genome Research ... approach,” says NIH Director Francis S. Collins, M.D., Ph.D. “The disorder had long-evaded conventional diagnosis.” ...

  20. Parkinson's Disease Research at NIH | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: Parkinson's Disease Parkinson's Disease Research at NIH Past Issues / Winter 2014 Table ... of its research: MedlinePlus . www.medlineplus.gov . Type "Parkinson's disease" in the Search box. NIHSeniorHealth —Parkinson's Disease http:// ...

  1. Precision Medicine: Healthcare Tailored to You | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. Feature: NIH Precision Medicine Initiative Precision Medicine: Healthcare Tailored to You Past Issues / Fall 2015 ... NIH researchers and fellow scientists working on precision medicine efforts gather on the NIH campus in Bethesda, ...

  2. Life Works: Explore Health and Medical Science Careers | NIH MedlinePlus the Magazine

    MedlinePlus

    ... at science.education.nih.gov/LifeWorks Darryl Lowery Photo courtesy of NIH Office of Science Education Darryl ... a refresher course and another test.” Vivian Morales Photo courtesy of NIH Office of Science Education Vivian ...

  3. Identifying the Right Disease Targets to Develop Better Drugs, Faster | NIH MedlinePlus the Magazine

    MedlinePlus

    ... initial $230 million invested by NIH through the Foundation for the NIH, and half coming from the ... Idec GlaxoSmithKline Lilly Non-Profit Organizations Alzheimer's Association Foundation for the NIH Geoffrey Beene Foundation USAgainst Alzheimers ...

  4. 42 CFR 63.5 - How will NIH make awards?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false How will NIH make awards? 63.5 Section 63.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.5 How will NIH make awards? Subject to the regulations of this part, the Director may...

  5. 42 CFR 63.5 - How will NIH make awards?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false How will NIH make awards? 63.5 Section 63.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.5 How will NIH make awards? Subject to the regulations of this part, the Director may...

  6. 42 CFR 63.5 - How will NIH make awards?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How will NIH make awards? 63.5 Section 63.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.5 How will NIH make awards? Subject to the regulations of this part, the Director may...

  7. 42 CFR 63.9 - How may NIH terminate awards?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false How may NIH terminate awards? 63.9 Section 63.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.9 How may NIH terminate awards? The Director may terminate a traineeship at...

  8. 42 CFR 63.5 - How will NIH make awards?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false How will NIH make awards? 63.5 Section 63.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.5 How will NIH make awards? Subject to the regulations of this part, the Director may...

  9. 42 CFR 63.5 - How will NIH make awards?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false How will NIH make awards? 63.5 Section 63.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.5 How will NIH make awards? Subject to the regulations of this part, the Director may...

  10. 42 CFR 63.9 - How may NIH terminate awards?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false How may NIH terminate awards? 63.9 Section 63.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.9 How may NIH terminate awards? The Director may terminate a traineeship at...

  11. 42 CFR 63.9 - How may NIH terminate awards?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false How may NIH terminate awards? 63.9 Section 63.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.9 How may NIH terminate awards? The Director may terminate a traineeship at...

  12. 42 CFR 63.9 - How may NIH terminate awards?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How may NIH terminate awards? 63.9 Section 63.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.9 How may NIH terminate awards? The Director may terminate a traineeship at...

  13. 42 CFR 63.9 - How may NIH terminate awards?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false How may NIH terminate awards? 63.9 Section 63.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING TRAINEESHIPS § 63.9 How may NIH terminate awards? The Director may terminate a traineeship at...

  14. Studies Evaluating NIH Training Grant and Fellowship Programs. Final Report.

    ERIC Educational Resources Information Center

    Holmstron, Engin I.

    The study describes current utilization of National Institute of Health (NIH) and National Institute of Mental Health (NIMH) graduate training support of institutions, departments, and individuals; it also assesses the impact of possible or actual changes in funding mechanisms. Statistical data show that NIH average contributions vary from 8 to…

  15. 42 CFR 52b.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How will NIH evaluate applications? 52b.5 Section 52b.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.5 How will NIH evaluate applications? (a) In evaluating...

  16. 42 CFR 52b.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false How will NIH evaluate applications? 52b.5 Section 52b.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.5 How will NIH evaluate applications? (a) In evaluating...

  17. 42 CFR 52b.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false How will NIH evaluate applications? 52b.5 Section 52b.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.5 How will NIH evaluate applications? (a) In evaluating...

  18. 42 CFR 52b.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false How will NIH evaluate applications? 52b.5 Section 52b.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.5 How will NIH evaluate applications? (a) In evaluating...

  19. 42 CFR 52b.5 - How will NIH evaluate applications?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false How will NIH evaluate applications? 52b.5 Section 52b.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.5 How will NIH evaluate applications? (a) In evaluating...

  20. The 50 Ah NiH2 CPV qualification tests

    NASA Technical Reports Server (NTRS)

    Garner, J. C.; Barnes, Wilbert L.; Hickman, Gary L.

    1995-01-01

    In 1992, the Naval Research Laboratory (NRL) started a program to qualify a large diameter common pressure vessel (CPV) nickel-hydrogen (NiH2) batteries for use on future Navy/NRL spacecraft electrical power subsystems. NRL's involvement with the qualification of CPV NiH2 batteries dates back to 1988 when COMSAT and Johnson Controls, Inc. initiated a joint effort to fly the first ever NiH2 CPV in space. A later NRL-JCI cooperative research and development agreement led to the launch of a space experiment in 1993 and to the use of a single NiH2 CPV battery on the BMDO Clementine spacecraft in 1994. NRL initiated procurement of two, 50 Ah CPV NiH2 batteries in the Fall of 1992. The two batteries were delivered to NRL in June 1994. NiH2 CPV batteries have almost 2x the specific energy (Wh/kg) of nickel cadium batteries and 2x the energy density (Wh/l) of individual pressure vessel NiH2 CPV's. This presentation discusses the results of electrical and mechanical qualification tests conducted at NRL. The tests included electrical characterization, standard capacity, random vibration, peak load, and thermal vacuum. The last slides of the presentation show initial results from the life cycle tests of the second NiH2 CPV battery at 40% depth of discharge and a temperature of 10 C.

  1. Publishing Practices of NIH-Funded Faculty at MIT

    ERIC Educational Resources Information Center

    Crummett, Courtney; Duranceau, Ellen Finnie; Gabridge, Tracy A.; Green, Remlee S.; Kajosalo, Erja; Noga, Michael M.; Silver, Howard J.; Stout, Amy

    2010-01-01

    Faculty and researchers who receive substantial funding from NIH were interviewed about their publication practices. Qualitative data was collected from interviews of eleven faculty members and one researcher representing six academic departments who received NIH funding. Interview responses were analyzed to identify a representative publication…

  2. Assessment of NIH Minority Research and Training Programs: Phase 3

    ERIC Educational Resources Information Center

    National Academies Press, 2005

    2005-01-01

    This report provides an assessment of NIH's programs for increasing the participation in biomedical science of individuals from underrepresented minority groups. The report examines, using available data and the results of a survey of NIH trainees, the characteristics and outcomes of programs at the undergraduate, graduate, postdoctoral, and…

  3. National Institutes of Health, Rodent 4 (NIH.R4); Calcium Metabolism and Vascular Function After Spaceflight: A Collaborative Series with NASA and NIH

    NASA Technical Reports Server (NTRS)

    Reiss-Bubenheim, Debra; Steele, Marianne; Aquillina, Rudy; Savage, Paul D. (Technical Monitor)

    1997-01-01

    The NIH.R4 payload was a collaborative experiment conducted by NASA's Ames Research Center in conjunction with the National Institutes of Health (NIH). This middeck payload was the fourth in a series of experiments focusing on developmental biology and the effects of microgravity on mammalian systems. The NIH.R4 payload was flown onboard STS-80, which launched November 19, 1996, and landed at Kennedy Space Center on December 7, 1996, and was the longest shuttle mission to date. Fourteen male Spontaneously Hypertensive rats (SHR) were flown; seven in each of two Animal Enclosure Modules (AEM) in the shuttle middeck. The flight animals were exposed to 18 days of microgravity. Two synchronous control groups were utilized for this study in addition to an asynchronous post-flight AEM control study conducted at the PI lab. The animals were fed two different calcium diets in the NASA food bar (2.0% and 0.2%) three weeks prior to launch and insight. Blood pressures were taken at pre-determined intervals and were the basis for flight selection. Upon recovery Dwight animals blood pressure was measured and a variety of tissues were collected. Project testing and data will be presented.

  4. The NIH Toolbox Cognition Battery: Results from a Large Normative Developmental Sample (PING)

    PubMed Central

    Akshoomoff, Natacha; Newman, Erik; Thompson, Wesley K.; McCabe, Connor; Bloss, Cinnamon S.; Chang, Linda; Amaral, David G.; Casey, B. J.; Ernst, Thomas M.; Frazier, Jean A.; Gruen, Jeffrey R.; Kaufmann, Walter E.; Kenet, Tal; Kennedy, David N.; Libiger, Ondrej; Mostofsky, Stewart; Murray, Sarah S.; Sowell, Elizabeth R.; Schork, Nicholas; Dale, Anders M.; Jernigan, Terry L.

    2014-01-01

    Objective The NIH Toolbox Cognition Battery (NTCB) was designed to provide a brief, efficient computerized test of key neuropsychological functions appropriate for use in children as young as 3 years of age. This report describes the performance of a large group of typically developing children and adolescents and examines the impact of age and sociocultural variables on test performance. Method The NTCB was administered to a sample of 1020 typically developing males and females ranging in age from 3 to 20 years, diverse in terms of socioeconomic status (SES) and race/ethnicity, as part of the new publicly accessible Pediatric Imaging, Neurocognition, and Genetics (PING) data resource, at 9 sites across the United States. Results General additive models of nonlinear age-functions were estimated from age-differences in test performance on the 8 NTCB subtests while controlling for family SES and genetic ancestry factors (GAFs). Age accounted for the majority of the variance across all NTCB scores, with additional significant contributions of gender on some measures, and of SES and race/ethnicity (GAFs) on all. After adjusting for age and gender, SES and GAFs explained a substantial proportion of the remaining unexplained variance in Picture Vocabulary scores. Conclusions The results highlight the sensitivity to developmental effects and efficiency of this new computerized assessment battery for neurodevelopmental research. Limitations are observed in the form of some ceiling effects in older children, some floor effects, particularly on executive function tests in the youngest participants, and evidence for variable measurement sensitivity to cultural/socioeconomic factors. PMID:24219608

  5. National Institutes of Health Osteoporosis and Related Bone Diseases~National Resource Center

    MedlinePlus

    ... Publications View Publications View Publications View Publications Research Resources Clinical Trials www.clinicaltrials.gov MedlinePlus www.nlm. ... The NIH Osteoporosis and Related Bone Diseases ~ National Resource Center is supported by the National Institute of ...

  6. Summary of an NIH workshop to identify research needs to improve the monitoring of iodine status in the United States and to inform the DRI.

    PubMed

    Swanson, Christine A; Zimmermann, Michael B; Skeaff, Sheila; Pearce, Elizabeth N; Dwyer, Johanna T; Trumbo, Paula R; Zehaluk, Christina; Andrews, Karen W; Carriquiry, Alicia; Caldwell, Kathleen L; Egan, S Kathleen; Long, Stephen E; Bailey, Regan Lucas; Sullivan, Kevin M; Holden, Joanne M; Betz, Joseph M; Phinney, Karen W; Brooks, Stephen P J; Johnson, Clifford L; Haggans, Carol J

    2012-06-01

    The Office of Dietary Supplements (ODS) at the NIH sponsored a workshop on May 12-13, 2011, to bring together representatives from various NIH institutes and centers as a first step in developing an NIH iodine research initiative. The workshop also provided an opportunity to identify research needs that would inform the dietary reference intakes for iodine, which were last revised in 2001. Iodine is required throughout the life cycle, but pregnant women and infants are the populations most at risk of deficiency, because iodine is required for normal brain development and growth. The CDC monitors iodine status of the population on a regular basis, but the status of the most vulnerable populations remains uncertain. The NIH funds very little investigator-initiated research relevant to iodine and human nutrition, but the ODS has worked for several years with a number of other U.S. government agencies to develop many of the resources needed to conduct iodine research of high quality (e.g., validated analytical methods and reference materials for multiple types of samples). Iodine experts, scientists from several U.S. government agencies, and NIH representatives met for 2 d to identify iodine research needs appropriate to the NIH mission. PMID:22551802

  7. Summary of an NIH Workshop to Identify Research Needs to Improve the Monitoring of Iodine Status in the United States and to Inform the DRI123

    PubMed Central

    Swanson, Christine A.; Zimmermann, Michael B.; Skeaff, Sheila; Pearce, Elizabeth N.; Dwyer, Johanna T.; Trumbo, Paula R.; Zehaluk, Christina; Andrews, Karen W.; Carriquiry, Alicia; Caldwell, Kathleen L.; Egan, S. Kathleen; Long, Stephen E.; Bailey, Regan Lucas; Sullivan, Kevin M.; Holden, Joanne M.; Betz, Joseph M.; Phinney, Karen W.; Brooks, Stephen P. J.; Johnson, Clifford L.; Haggans, Carol J.

    2012-01-01

    The Office of Dietary Supplements (ODS) at the NIH sponsored a workshop on May 12–13, 2011, to bring together representatives from various NIH institutes and centers as a first step in developing an NIH iodine research initiative. The workshop also provided an opportunity to identify research needs that would inform the dietary reference intakes for iodine, which were last revised in 2001. Iodine is required throughout the life cycle, but pregnant women and infants are the populations most at risk of deficiency, because iodine is required for normal brain development and growth. The CDC monitors iodine status of the population on a regular basis, but the status of the most vulnerable populations remains uncertain. The NIH funds very little investigator-initiated research relevant to iodine and human nutrition, but the ODS has worked for several years with a number of other U.S. government agencies to develop many of the resources needed to conduct iodine research of high quality (e.g., validated analytical methods and reference materials for multiple types of samples). Iodine experts, scientists from several U.S. government agencies, and NIH representatives met for 2 d to identify iodine research needs appropriate to the NIH mission. PMID:22551802

  8. Expression of Nanog gene promotes NIH3T3 cell proliferation

    SciTech Connect

    Zhang Jingyu; Wang Xia; Chen Bing; Suo Guangli; Zhao Yanhong; Duan Ziyuan; Dai Jianwu . E-mail: jwdai@genetics.ac.cn

    2005-12-16

    Cells are the functional elements in tissue engineering and regenerative medicine. A large number of cells are usually needed for these purposes. However, there are numbers of limitations for in vitro cell proliferation. Nanog is an important self-renewal determinant in embryonic stem cells. However, it remains unknown whether Nanog will influence the cell cycle and cell proliferation of mature cells. In this study, we expressed Nanog in NIH3T3 cells and showed that expression of Nanog in NIH3T3 promoted cells to enter into S phase and enhanced cell proliferation. This suggests that Nanog gene might function in a similar fashion in mature cells as in ES cells. In addition, it may provide an approach for in vitro cell expansion.

  9. 75 FR 69687 - Office of Biotechnology Activities Recombinant DNA Research: Proposed Actions Under the NIH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities Recombinant DNA Research: Proposed Actions Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines... the NIH Recombinant DNA Advisory Committee (RAC) and specifically approved by the NIH Director as...

  10. Sizing the Problem of Improving Discovery and Access to NIH-Funded Data: A Preliminary Study

    PubMed Central

    2015-01-01

    Objective This study informs efforts to improve the discoverability of and access to biomedical datasets by providing a preliminary estimate of the number and type of datasets generated annually by research funded by the U.S. National Institutes of Health (NIH). It focuses on those datasets that are “invisible” or not deposited in a known repository. Methods We analyzed NIH-funded journal articles that were published in 2011, cited in PubMed and deposited in PubMed Central (PMC) to identify those that indicate data were submitted to a known repository. After excluding those articles, we analyzed a random sample of the remaining articles to estimate how many and what types of invisible datasets were used in each article. Results About 12% of the articles explicitly mention deposition of datasets in recognized repositories, leaving 88% that are invisible datasets. Among articles with invisible datasets, we found an average of 2.9 to 3.4 datasets, suggesting there were approximately 200,000 to 235,000 invisible datasets generated from NIH-funded research published in 2011. Approximately 87% of the invisible datasets consist of data newly collected for the research reported; 13% reflect reuse of existing data. More than 50% of the datasets were derived from live human or non-human animal subjects. Conclusion In addition to providing a rough estimate of the total number of datasets produced per year by NIH-funded researchers, this study identifies additional issues that must be addressed to improve the discoverability of and access to biomedical research data: the definition of a “dataset,” determination of which (if any) data are valuable for archiving and preservation, and better methods for estimating the number of datasets of interest. Lack of consensus amongst annotators about the number of datasets in a given article reinforces the need for a principled way of thinking about how to identify and characterize biomedical datasets. PMID:26207759

  11. 42 CFR 68a.15 - Additional conditions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Additional conditions. 68a.15 Section 68a.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS FROM DISADVANTAGED BACKGROUNDS (CR-LRP) §...

  12. 42 CFR 68a.15 - Additional conditions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Additional conditions. 68a.15 Section 68a.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS...

  13. 42 CFR 68a.15 - Additional conditions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Additional conditions. 68a.15 Section 68a.15 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS...

  14. NIH scientists provide new insight into rare kidney cancer

    Cancer.gov

    NIH scientists have discovered a unique feature of a rare, hereditary form of kidney cancer that may provide a better understanding of its progression and metastasis, possibly laying the foundation for the development of new targeted therapies.

  15. Physical Activity | NIH MedlinePlus the Magazine

    MedlinePlus

    ... visit www.niddk.nih.gov/health-information/health-communication-programs/win/Pages/community-groups-organizations.aspx Find Out More School Health: medlineplus.gov/schoolhealth.html Healthy Back to ...

  16. Transforming Discovery into Health | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn Javascript on. Transforming Discovery into Health, From NIH Director Dr. Francis S. Collins Past Issues / ... social sciences research initiative. Shortening the Pathway to Health Whatever the disease, be it depression, diabetes, or ...

  17. Preventing Falls | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Osteoporosis Preventing Falls Past Issues / Winter 2011 Table of ... next to your bed Free NIH Videos About Osteoporosis The NIHSeniorHealth Web site features five brief, informative ...

  18. We Can! | NIH MedlinePlus the Magazine

    MedlinePlus

    ... child-centered nutrition and physical activity program from four NIH Institutes. "My mom and I work together ... Human Development, and the National Cancer Institute. The Weight-control Information Network (WIN) , sponsored by the National Institute ...

  19. NIH Abroad: Inspiring the Next Generation of Global Health Researchers

    MedlinePlus

    ... Section NIH Abroad: Inspiring the Next Generation of Global Health Researchers Past Issues / Spring 2008 Table of ... turn Javascript on. Inspiring the Next Generation of Global Health Researchers Fogarty scholar helps Zambians fight cervical ...

  20. Advances in Sleep Studies | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: Sleep Disorders Advances in Sleep Studies Past Issues / Summer 2015 ... is the director of the National Center on Sleep Disorders Research (NCSDR) in the NIH's National Heart, Lung, ...

  1. Precision Medicine In Action | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. Feature: NIH Precision Medicine Initiative Precision Medicine In Action Past Issues / Fall 2015 Table of ... Dishman "I am totally motivated to support precision medicine because I am one of the early prototype ...

  2. Cracking the Genetic Code | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Cracking the Genetic Code, From NIH Director Dr. Francis S. Collins Past ... moment in science in 2000: Cracking of the genetic code raised the prospect of pinpointing the root ...

  3. US bill seeks to overturn NIH research-archiving rule

    NASA Astrophysics Data System (ADS)

    Gwynne, Peter

    2012-03-01

    A bipartisan bill introduced in the US House of Representatives aims to reverse 2008 legislation that requires recipients of National Institutes of Health (NIH) grants to make copies of their peer-reviewed papers freely available online.

  4. What is COPD? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... please turn JavaScript on. Feature: The Challenge of COPD What is COPD? Past Issues / Fall 2014 Table of Contents COPD ... a walk, even washing and dressing. What Is COPD? Watch an animation at: www.nhlbi.nih.gov/ ...

  5. Diabetes Complications | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Diabetes Complications Tailoring Diabetes Treatment to the Patient Past Issues / Fall 2012 ... been reported for the treatment of type 2 diabetes. How was the NIH involved? These are guidelines ...

  6. Treating Cataracts | NIH MedlinePlus the Magazine

    MedlinePlus

    ... her experience recently with NIH MedlinePlus magazine. What did you notice about your vision that told you ... how long it would take to recover. Where did you go for information about cataracts and surgery? ...

  7. Progress in Paralysis | NIH MedlinePlus the Magazine

    MedlinePlus

    ... the NIH's National Institute of Biomedical Imaging and Bioengineering (NIBIB) Photo courtesy of National Institute of Biomedical Imaging and Bioengineering Roderic I. Pettigrew, Ph.D., M.D., is ...

  8. Symptoms, Treatment and Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... affects more than two million Americans," observes Mark Johnson, professor of biomedical and mechanical engineering at Northwestern University's McCormick School of Engineering and Applied Science. Johnson led the research, supported by NIH and other ...

  9. Facing Fibromyalgia | NIH MedlinePlus the Magazine

    MedlinePlus

    ... with NIH MedlinePlus magazine about her conditions. When did you start having symptoms of fibromyalgia? I actually ... with my right wrist since the third grade. Did your problems become more severe over time? Yes, ...

  10. NIH's National Institute of Nursing Research Is Changing Lives

    MedlinePlus

    ... Current Issue Past Issues NIH's National Institute of Nursing Research Is Changing Lives Past Issues / Spring 2008 ... on. From childbirth to end-of-life care, nursing research is aimed at helping patients across the ...

  11. The Zika Virus | NIH MedlinePlus the Magazine

    MedlinePlus

    ... please turn JavaScript on. Feature: Infectious Diseases The Zika Virus Past Issues / Spring 2016 Table of Contents ... Photo Courtesy of NIH "You could have a Zika virus vaccine in large-scale clinical trials in ...

  12. Protect Yourself Against HPV | NIH MedlinePlus the Magazine

    MedlinePlus

    ... and his NIH colleague Dr. John Schiller. Both HPV vaccines, called Gardasil and Cervarix, protect against the two ... part of the throat (the oropharynx). Thus, the HPV vaccines should protect against all these forms of cancer. ...

  13. Cracking the Genetic Code | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Cracking the Genetic Code, From NIH Director Dr. Francis S. Collins ... must be a lot going on there. "Over the next 10 years, more and more people will ...

  14. Drug Facts Chat Day: NIH Experts Answer Students' Drug Questions

    MedlinePlus

    ... Home Current Issue Past Issues Drug Facts Chat Day: NIH Experts Answer Students' Drug Questions Past Issues / ... Drug Abuse during their first Drug Facts Chat Day. Photo courtesy of NIDA The questions poured in… ...

  15. NIH Scientists Shed Light on Mystery Surrounding Hepatitis B Virus

    MedlinePlus

    ... Research 2013 January 2013 (historical) NIH Scientists Shed Light on Mystery Surrounding Hepatitis B Virus Discovery Is ... the University of Oxford, U.K., have shed light on a long-standing enigma about the structure ...

  16. NIH MedlinePlus the Magazine: Health, Medical & Wellness Articles

    MedlinePlus

    ... sponsorship and other charitable donations for NIH MedlinePlus magazine's publication and distribution, many more thousands of Americans will gain valuable, free access to the world's best online medical library, ... 4720 Montgomery Lane, Suite 500, Bethesda, MD 20814.

  17. [The status of NIHS Information and Computing Infrastructure (NICI)].

    PubMed

    Nakata, K; Nakano, T; Takai, T; Komine, K; Kaminuma, T

    2000-01-01

    From 1999 to 2000, NIHS Information and Computing Infrastructure (NICI) were newly renovated. The purposes of the renovation are (1) the improvement of the communication for business works in NIHS, (2) supporting for the research, (3) supporting for the administration work. The Internet connection speed was upgraded from 256 Kbps to 1.5 Mbps. The high quality network sever machines and database server machines were installed. The large-scale software systems were renewed their versions. Four experimental stations for medical plants at Hokkaido, Izu, Wakayama and Tanegashima connected to NIHS at Tokyo or Osaka branch by ISDN. We describe the providing information on NIHS home page, and how to utilize NICI for our research and official works. PMID:11534109

  18. From the NIH Director: The Value of Medical Research

    MedlinePlus

    ... 1940s and 1950s, NIH implemented the double-blind, randomized, prospective trial. It remains the gold standard today. ... demonstrate, in a statistically valid way, through a randomized trial, that the mortality rate from heart disease ...

  19. Survey of community engagement in NIH-funded research.

    PubMed

    Hood, Nancy E; Brewer, Tracy; Jackson, Rebecca; Wewers, Mary Ellen

    2010-02-01

    Community engagement is an innovative and required component for Clinical and Translational Science Awards (CTSAs) funded by the National Institutes of Health (NIH). However, the extent of community engagement in NIH-funded research has not been previously examined. This study assessed baseline prevalence of community engagement activities among NIH-funded studies at a large Midwestern university with a CTSA. An online survey was e-mailed to principal investigators of recent NIH-funded studies (N = 480). Investigators were asked to identify what types of community engagement activities had occurred for each study. Responses were received for 40.4% (194/480) of studies. Overall, 42.6% reported any community engagement activities. More collaborative types of engagement (e.g., community advisory board) were less common than activities requiring less engagement (e.g., sharing study results with community members). Studies with more collaborative community engagement were less likely to be described as basic or preclinical research compared to all other studies. Given NIH's inclusive call for community engagement in research, relatively few NIH-funded studies reported community engagement activities, although this study used a broad definition of community and a wide range of types of engagement. These findings may be used to inform the goals of CTSA community engagement programs. PMID:20443949

  20. NIH Clinical Center: There’s No Other Hospital Like It | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Center houses 240 inpatient beds, 82 day-hospital stations, and more than 1,600 laboratories that conduct ... steps away from the NIH Clinical Center, providing space for solitude, family meetings, and supportive fellowship. Training ...

  1. Mobile Technology and Health Care, From NIH Director Dr. Francis S. Collins | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn Javascript on. Mobile Technology and Health Care, From NIH Director Dr. Francis S. Collins Past Issues / Winter 2011 Table of Contents Mobile health, or mHealth for short, uses mobile technologies for ...

  2. New NIH-funded Ultrasound Technology is Changing Lives around the World | NIH MedlinePlus the Magazine

    MedlinePlus

    ... version of this page please turn Javascript on. New NIH-funded Ultrasound Technology is Changing Lives around ... on applying these devices," says Dr. Thomenius. "The new targets are primary care doctors, anesthesiologists, interventionalists, and ...

  3. Resources, resources, resources....

    PubMed

    1997-01-01

    Several resources provided by different types of organizations are available to transgender people in the New York area. Some of these organizations include the Gender Identity Project, Harlem United Community AIDS Center, Hetrick Martin Institute, SafeSpace and Youth Enrichment Services (YES). Organization telephone numbers, addresses, and their targeted audiences are provided. PMID:11364801

  4. Assessment of potential additions to conventional oil and gas resources of the world (outside the United States) from reserve growth, 2012

    USGS Publications Warehouse

    Klett, Timothy R.; Cook, Troy A.; Charpentier, Ronald R.; Tennyson, Marilyn E.; Attanasi, E.D.; Freeman, Phil A.; Ryder, Robert T.; Gautier, Donald L.; Verma, Mahendra K.; Le, Phuong A.; Schenk, Christopher J.

    2012-01-01

    The U.S. Geological Survey estimated volumes of technically recoverable, conventional petroleum resources resulting from reserve growth for discovered fields outside the United States that have reported in-place oil and gas volumes of 500 million barrels of oil equivalent or greater. The mean volumes were estimated at 665 billion barrels of crude oil, 1,429 trillion cubic feet of natural gas, and 16 billion barrels of natural gas liquids. These volumes constitute a significant portion of the world's oil and gas resources.

  5. Genetic manipulation: NIH concede part of Rifkin suit.

    PubMed

    Budiansky, S

    Officials at the National Institutes of Health (NIH) have acceded to a major claim in a lawsuit brought by anti-genetic engineering activist Jeremy Rifkin to halt field trials involving the release of recombinant organisms into the environment. In an appeal filed with the U.S. Circuit Court of Appeals in Washington, NIH agreed to produce an environmental assessment of individual experiments as demanded by U.S. District Court Judge John Sirica in May, while continuing to appeal Sirica's ruling that an impact statement on the full environmental release program is required. The appeals court is scheduled to hear the case in December. Meanwhile, on another front, the NIH Recombinant DNA Advisory Committee has rejected another Rifkin proposal to ban all transfers of genetic materials from one mammalian species to the germline of another. PMID:6594575

  6. NIH Precision Medicine Initiative: Implications for Diabetes Research.

    PubMed

    Fradkin, Judith E; Hanlon, Mary C; Rodgers, Griffin P

    2016-07-01

    In his January 2015 State of the Union address, President Barack Obama announced a new Precision Medicine Initiative (PMI) to personalize approaches toward improving health and treating disease (www.whitehouse.gov/precision-medicine). He stated that the goal of such an initiative was "to bring us closer to curing diseases like cancer and diabetes, and to give all of us access to the personalized information we need to keep ourselves and our families healthier." Since that time, the National Institutes of Health (NIH) has taken a leadership role in implementing the President's vision related to biomedical research (www.nih.gov/precisionmedicine). Here, we discuss the NIH component of the PMI, related ongoing diabetes research, and near-term research that could position the diabetes field to take full advantage of the opportunities that stem from the PMI. PMID:27289128

  7. Assessment of potential additions to conventional oil and gas resources in discovered fields of the United States from reserve growth, 2012

    USGS Publications Warehouse

    U.S. Geological Survey Reserve Growth Assessment Team

    2012-01-01

    The U.S. Geological Survey estimated volumes of technically recoverable, conventional petroleum resources that have the potential to be added to reserves from reserve growth in 70 discovered oil and gas accumulations of the United States, excluding Federal offshore areas. The mean estimated volumes are 32 billion barrels of crude oil, 291 trillion cubic feet of natural gas, and 10 billion barrels of natural gas liquids.

  8. To Your Health: NLM update transcript - NIH MedlinePlus magazine Spring 2016

    MedlinePlus

    ... To Your Health: NLM update Transcript NIH MedlinePlus magazine Spring 2016 : 06/06/2016 To use the ... weekly topics. The new edition of NIH MedlinePlus magazine covers fibromyalgia, health disparities, as well as women ...

  9. NIH's National Institute of General Medical Sciences celebrates 45 years of Discovery for Health

    MedlinePlus

    ... Alison Davis NIH's National Institute of General Medical Sciences celebrates 45 years of Discovery for Health The National Institute of General Medical Sciences (NIGMS) is the NIH institute that primarily supports ...

  10. Peanut Allergy Prevention Strategy is Nutritionally Safe, NIH-funded Study Shows

    MedlinePlus

    ... Stem Cell Information OppNet NIDB NIH Blueprint for Neuroscience Research Institutes at NIH List of Institutes, Centers & ... These findings are a secondary result from the Learning Early About Peanut Allergy (LEAP) clinical trial, which ...

  11. New NIH Director Dr. Francis Collins on Medical Research That Benefits Everyone's Health

    MedlinePlus

    ... benefit everyone's health." — NIH Director Dr. Francis Collins Healthcare Reform— We can put science to work to better ... of this? Under the American Recovery and Reinvestment Act, NIH has received $10 billion in stimulus funding, ...

  12. Alcohol Use Disorders, Research Findings | NIH MedlinePlus the Magazine

    MedlinePlus

    ... rethinkingdrinking.niaaa.nih.gov/default.asp Fetal alcohol spectrum disorders web page www.niaaa.nih.gov/research/major-initiatives/fetal-alcohol-spectrum-disorders . Spectrum e-zine story: Underage drinking: One ...

  13. 75 FR 42114 - Office of Biotechnology Activities; Recombinant DNA Research: Proposed Action Under the NIH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities; Recombinant DNA Research: Proposed Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH... transgenic rodents by recombinant DNA technology must be registered with the Institutional...

  14. Coffee to Go: Woman "Thinks" First Cup in 15 Years | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Out More National Institute of Biomedical Imaging and Bioengineering (NIBIB) www.nibib.nih.gov/ NIBIB Rehabilitation Engineering ... of NIH's National Institute of Biomedical Imaging and Bioengineering (NIBIB), which supports the research. The ultimate goal ...

  15. Despite the Shutdown, Rescheduled NIH Research Festival Brings Science to the Forefront | Poster

    Cancer.gov

    By Andrea Frydl, Contributing Writer Although it was delayed by almost a month because of the federal shutdown, the NIH Research Festival still took place at the NIH Clinical Center in Bethesda, Md., and attendance was high.

  16. 78 FR 50424 - NIH Cooperative Research and Development Agreement Program: Invitation To Solicit Nonclinical and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... HUMAN SERVICES National Institutes of Health NIH Cooperative Research and Development Agreement Program: Invitation To Solicit Nonclinical and Clinical Research Proposals From NIH Intramural Research Program... organizations); public and private foundations and nonprofit organizations to solicit research proposals...

  17. Alcohol Use Disorders, Research Findings | NIH MedlinePlus the Magazine

    MedlinePlus

    ... booklet www.rethinkingdrinking.niaaa.nih.gov/default.asp Fetal alcohol spectrum disorders web page www.niaaa.nih.gov/research/major-initiatives/fetal-alcohol-spectrum-disorders . Spectrum e-zine story: Underage drinking: One step ...

  18. FNLM 2013 Events & Programs Announced | NIH MedlinePlus the Magazine

    MedlinePlus

    ... http://m.medlineplus.gov/spanish Tune in: NIH Radio Free podcast audio reports on your computer or personal audio player www.nih.gov/news/radio/nihpodcast.htm Winter 2013 Issue: Volume 7 Number ...

  19. National Center for Biotechnology Information Celebrates 25th Anniversary | NIH MedlinePlus the Magazine

    MedlinePlus

    ... http://m.medlineplus.gov/spanish Tune in: NIH Radio Free podcast audio reports on your computer or personal audio player www.nih.gov/news/radio/nihpodcast.htm Winter 2014 Issue: Volume 8 Number ...

  20. Building Paths to Health Careers | NIH MedlinePlus the Magazine

    MedlinePlus

    ... http://m.medlineplus.gov/spanish Tune in: NIH Radio Free podcast audio reports on your computer or personal audio player www.nih.gov/news/radio/nihpodcast.htm Spring 2012 Issue: Volume 7 Number ...

  1. Go4Life® Making Smart Food Choices | NIH MedlinePlus the Magazine

    MedlinePlus

    ... turn JavaScript on. Feature: Healthy Aging Making Smart Food Choices Past Issues / Winter 2015 Table of Contents ... NIH www.nia.nih.gov/Go4Life Making Smart Food Choices To maintain a healthy weight, balance the ...

  2. NIH Researchers Find Resveratrol Helps Protect Against Diabetes in Animal Study

    MedlinePlus

    ... Us FAQs Stay Connected You are here Home NIH researchers find resveratrol helps protect against diabetes in ... 10.2337/db13-0266 Share this: ​ Connect with NIH Disclaimer Accessibility Policies Contact Us FOIA Get Acrobat ( ...

  3. Precision Medicine: Healthcare Tailored to You | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: NIH Precision Medicine Initiative Precision Medicine: Healthcare Tailored to You Past Issues / Fall 2015 Table of Contents NIH researchers and fellow scientists working on precision medicine ...

  4. 75 FR 2551 - NIH Consensus Development Conference: Lactose Intolerance and Health; Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health NIH Consensus Development Conference: Lactose Intolerance and Health; Notice Notice is hereby given by the National Institutes of Health (NIH) of the ``NIH Consensus Development Conference:...

  5. NIH workshop summary: shaping the development of an iodine research initiative for the U.S.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Office of Dietary Supplements (ODS) at NIH sponsored a workshop May 12–13, 2011, to bring together representatives from various NIH Institutes and Centers as a first step in developing an NIH iodine initiative. The workshop also provided an opportunity to identify research needs that would infor...

  6. 76 FR 3150 - Office of Biotechnology Activities; Recombinant DNA Research: Action Under the NIH Guidelines for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ...). On July 20, 2010 the NIH Office of Biotechnology Activities (OBA) published a proposed action (75 FR... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities; Recombinant DNA Research: Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH...

  7. 42 CFR 68.6 - How do individuals apply to participate in the NIH LRPs?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false How do individuals apply to participate in the NIH... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.6 How do individuals apply to participate in the NIH LRPs? An application for participation in an...

  8. 42 CFR 68.15 - When can an NIH LRP payment obligation be discharged in bankruptcy?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false When can an NIH LRP payment obligation be... HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.15 When can an NIH LRP payment obligation be discharged in bankruptcy? Any...

  9. 42 CFR 68.15 - When can an NIH LRP payment obligation be discharged in bankruptcy?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false When can an NIH LRP payment obligation be... HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.15 When can an NIH LRP payment obligation be discharged in bankruptcy? Any...

  10. 42 CFR 68.8 - What do the NIH LRPs provide to participants?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false What do the NIH LRPs provide to participants? 68.8..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.8 What do the NIH LRPs provide to participants? (a) Loan repayments: For each year of the applicable service...

  11. 42 CFR 68.8 - What do the NIH LRPs provide to participants?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false What do the NIH LRPs provide to participants? 68.8..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.8 What do the NIH LRPs provide to participants? (a) Loan repayments: For each year of the applicable service...

  12. 42 CFR 68.6 - How do individuals apply to participate in the NIH LRPs?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false How do individuals apply to participate in the NIH... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.6 How do individuals apply to participate in the NIH LRPs? An application for participation in an...

  13. NIH Casts Critical Eye on How It Gives Grants

    ERIC Educational Resources Information Center

    Brainard, Jeffrey

    2007-01-01

    The National Institutes of Health's methods for reviewing and financing academic research proposals are often praised as the gold standard. Some American scientists, though, have recently offered less flattering descriptions, like "broken" and "arbitrary." NIH officials have heard both arguments, and plenty in between, in recent months. They have…

  14. NIH Turns Blind Eye to Academics' Financial Conflicts, Audit Says

    ERIC Educational Resources Information Center

    Brainard, Jeffrey

    2008-01-01

    Hundreds of financial conflicts of interest among university researchers have not been investigated by the National Institutes of Health, an agency that should police them, according to a new audit report. The report, by the inspector general of the Department of Health and Human Services--NIH's parent agency--describes a dysfunctional system that…

  15. HealthLines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... than 100,000 patients covering nearly a decade. Researchers say a clinical trial would be an important next step. NIH's National Library of Medicine helped fund the study. Anti-Smoking Med Shows Promise for Treating Alcohol Dependence A smoking-cessation medicine may be a ...

  16. NIH researchers complete whole-exome sequencing of skin cancer

    Cancer.gov

    A team led by researchers at NIH is the first to systematically survey the landscape of the melanoma genome, the DNA code of the deadliest form of skin cancer. The researchers have made surprising new discoveries using whole-exome sequencing, an approach that decodes the 1-2 percent of the genome that contains protein-coding genes.

  17. I. NIH Toolbox Cognition Battery (CB): introduction and pediatric data.

    PubMed

    Weintraub, Sandra; Bauer, Patricia J; Zelazo, Philip David; Wallner-Allen, Kathleen; Dikmen, Sureyya S; Heaton, Robert K; Tulsky, David S; Slotkin, Jerry; Blitz, David L; Carlozzi, Noelle E; Havlik, Richard J; Beaumont, Jennifer L; Mungas, Dan; Manly, Jennifer J; Borosh, Beth G; Nowinski, Cindy J; Gershon, Richard C

    2013-08-01

    This monograph presents the pediatric portion of the National Institutes of Health (NIH) Toolbox Cognition Battery (CB) of the NIH Toolbox for the Assessment of Neurological and Behavioral Function. The NIH Toolbox is an initiative of the Neuroscience Blueprint, a collaborative framework through which 16 NIH Institutes, Centers, and Offices jointly support neuroscience-related research, to accelerate discoveries and reduce the burden of nervous system disorders. The CB is one of four modules that measure cognitive, emotional, sensory, and motor health across the lifespan. The CB is unique in its continuity across childhood, adolescence, early adulthood, and old age, and in order to help create a common currency among disparate studies, it is also available at low cost to researchers for use in large-scale longitudinal and epidemiologic studies. This chapter describes the evolution of the CB; methods for selecting cognitive subdomains and instruments; the rationale for test design; and a validation study in children and adolescents, ages 3-15 years. Subsequent chapters feature detailed discussions of each test measure and its psychometric properties (Chapters 2-6), the factor structure of the test battery (Chapter 7), the effects of age and education on composite test scores (Chapter 8), and a final summary and discussion (Chapter 9). As the chapters in this monograph demonstrate, the CB has excellent psychometric properties, and the validation study provided evidence for the increasing differentiation of cognitive abilities with age. PMID:23952199

  18. NIH Peer Review: Scored Review Criteria and Overall Impact

    ERIC Educational Resources Information Center

    Lindner, Mark D.; Vancea, Adrian; Chen, Mei-Ching; Chacko, George

    2016-01-01

    The National Institutes of Health (NIH) is the largest source of funding for biomedical research in the world. Funding decisions are made largely based on the outcome of a peer review process that is intended to provide a fair, equitable, timely, and unbiased review of the quality, scientific merit, and potential impact of the research. There have…

  19. Policy Implications of Aging in the NIH-Funded Workforce.

    PubMed

    Heggeness, Misty L; Carter-Johnson, Frances; Schaffer, Walter T; Rockey, Sally J

    2016-07-01

    Because of national interest in the "graying" of the biomedical workforce, we examine aging and funding within the pool of NIH-funded investigators and applicants, particularly in the growing field of stem cell research. We provide evidence of a maturing and more competitive stem cell workforce and discuss policy implications. PMID:27392223

  20. How Is Psoriasis Treated? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Javascript on. Feature: Living with Psoriasis How Is Psoriasis Treated? Past Issues / Fall 2013 Table of Contents Find Out More MedlinePlus — www.medlineplus.gov National Institute of Arthritis and Musculoskeletal and Skin Diseases — www.niams.nih. ...

  1. 42 CFR 52e.6 - How will NIH evaluate applications?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the applicable cost principles prescribed in subpart Q of 45 CFR part 74. ... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.6 How will NIH... the prevention, diagnosis, or treatment of heart, blood vessel, lung, or blood diseases of...

  2. 42 CFR 52e.6 - How will NIH evaluate applications?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the applicable cost principles prescribed in subpart Q of 45 CFR part 74. ... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.6 How will NIH... the prevention, diagnosis, or treatment of heart, blood vessel, lung, or blood diseases of...

  3. 42 CFR 52e.6 - How will NIH evaluate applications?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the applicable cost principles prescribed in subpart Q of 45 CFR part 74. ... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.6 How will NIH... the prevention, diagnosis, or treatment of heart, blood vessel, lung, or blood diseases of...

  4. 42 CFR 52e.6 - How will NIH evaluate applications?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the applicable cost principles prescribed in subpart Q of 45 CFR part 74. ... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.6 How will NIH... the prevention, diagnosis, or treatment of heart, blood vessel, lung, or blood diseases of...

  5. 42 CFR 52e.6 - How will NIH evaluate applications?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the applicable cost principles prescribed in subpart Q of 45 CFR part 74. ... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.6 How will NIH... the prevention, diagnosis, or treatment of heart, blood vessel, lung, or blood diseases of...

  6. Subscribe to NIH MedlinePlus the Magazine

    MedlinePlus

    ... published quarterly, in print and on the Web. Print subscriptions Sign up for a free subscription to NIH MedlinePlus Magazine. Librarians may order this magazine in bulk . Please note that print orders are only shipped within the United States. ...

  7. Precision Medicine In Action | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn JavaScript on. Feature: NIH Precision Medicine Initiative Precision Medicine In Action Past Issues / Fall 2015 Table of ... Eric Dishman "I am totally motivated to support precision medicine because I am one of the early prototype ...

  8. Keep Gum Disease Away! | NIH MedlinePlus the Magazine

    MedlinePlus

    ... to be very careful when it comes to oral surgery. "Remember, it can't be done twice. So get the most experienced team possible." And he's become a stickler for good dental ... NIH Senior Health: http://nihseniorhealth.gov Registry ...

  9. Ni-H2 cell characterization for INTELSAT programs

    NASA Technical Reports Server (NTRS)

    Dunnet, Andrew F.; Earl, Martin W.

    1994-01-01

    Various Ni/H2 cell designs manufactured for INTELSAT Programs during the past decade have been characterized electrically as a function of temperature. The resulting data for these INTELSAT V, VI, VII and VIIA cells are assembled in a manner which allows ready comparison of performance. Also included is a detailed description of each design.

  10. NIH Health Disparities Strategic Plan, Fiscal Years 2004-2008

    ERIC Educational Resources Information Center

    National Human Genome Research Institute, 2008

    2008-01-01

    The National Human Genome Research Institute (NHGRI) led the National Institutes of Health's (NIH) contribution to the International Human Genome Project, whose primary goal was the sequencing of the human genome. This project was successfully completed in April 2003. Now, the NHGRI's mission is focused on a broad range of studies aimed at…

  11. NIH Mulls Ways to Lure Back Veteran Peer Reviewers

    ERIC Educational Resources Information Center

    Brainard, Jeffrey

    2008-01-01

    Not long ago, academic scientists welcomed calls from the National Institutes of Health (NIH) asking them to volunteer as peer reviewers. Many were glad for the opportunity to help distribute billions of dollars in federal biomedical-research grants even though the service required a big time commitment--the equivalent of one month a year to…

  12. A Crowdsourcing Evaluation of the NIH Chemical Probes

    PubMed Central

    Oprea, Tudor I.; Bologa, Cristian G.; Boyer, Scott; Curpan, Ramona F.; Glen, Robert C.; Hopkins, Andrew L.; Lipinski, Christopher A.; Marshall, Garland R.; Martin, Yvonne C.; Ostopovici-Halip, Liliana; Rishton, Gilbert; Ursu, Oleg; Vaz, Roy J.; Waller, Chris; Waldmann, Herbert; Sklar, Larry A.

    2013-01-01

    Between 2004 and 2008, the NIH molecular libraries and imaging initiative (MLI) pilot phase funded ten high-throughput Screening Centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the MLI output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes. PMID:19536101

  13. HealthLines | NIH MedlinePlus the Magazine

    MedlinePlus

    ... a statin at two Boston hospitals. Researchers developed software that allowed them to scour more than 5 million notes on more than 100,000 patients covering nearly a decade. Researchers say a clinical trial would be an important next step. NIH's National ...

  14. How Is Psoriasis Treated? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn Javascript on. Feature: Living with Psoriasis How Is Psoriasis Treated? Past Issues / Fall 2013 Table of Contents ... nih.gov/ Clinical Trials — www.clinicaltrials.gov National Psoriasis Foundation — www.psoriasis.org American Academy of Dermatology — ...

  15. S.T.A.R.T.T. plus: addition of prehospital personnel to a national multidisciplinary crisis resource management trauma team training course

    PubMed Central

    Gillman, Lawrence M.; Martin, Doug; Engels, Paul T.; Brindley, Peter; Widder, Sandy; French, Cheryl

    2016-01-01

    Summary The Simulated Trauma and Resuscitation Team Training (S.T.A.R.T.T.) course is a unique multidisciplinary trauma team training course deliberately designed to address the common crisis resource management (CRM) skills of trauma team members. Moreover, the curriculum has been updated to also target the specific learning needs of individual participating professionals: physicians, nurses and respiratory therapists. This commentary outlines further modifications to the course curriculum in order to address the needs of a relatively undertargeted group: prehospital personnel (i.e., emergency medical services). Maintenance of high participant satisfaction, regardless of profession, suggests that the S.T.A.R.T.T. course can be readily modified to incorporate prehospital personnel without losing its utility or popularity. PMID:26574706

  16. Clinical research at a crossroads: the NIH roadmap.

    PubMed

    Zerhouni, Elias A

    2006-05-01

    As a result of the NIH investment in biomedical research, over the past 30 years we have seen many great advances impacting the health of our nation which have been fostered by the effective translation of scientific advances. However, rising costs for both research and health care mean that the NIH must make strategic decisions that maximize the return on its investment. Because treating end-stage disease is so costly, both personally and financially, learning how to pre-empt illness through molecular knowledge and behavioral interventions is the only viable strategy for maintaining the nation's health in the coming years. In order to speed scientific discovery and its efficient translation to patient care, the NIH developed the Roadmap for Biomedical Research. The Roadmap provides an incubator space for funding innovative programs to address a panoply of scientific challenges and has engendered a new culture of cooperation among researchers seeking new avenues for collaboration. An important feature of the Roadmap is the Clinical and Translational Science Awards (CTSA). The program's goals are to eliminate growing barriers between clinical and basic research, to address the increasing complexities involved in conducting clinical research, and to help institutions nationwide create an academic home for clinical and translational science. By adopting a strong strategic vision now, the NIH will be able to stand at the ready as future challenges and opportunities emerge. In keeping with our mission, the NIH's current and future actions will be defined by the requirements of the scientific community and the public health needs of the nation. PMID:17152855

  17. REPORT OF THE NIH TASK FORCE ON RESEARCH STANDARDS FOR CHRONIC LOW BACK PAIN

    PubMed Central

    Deyo, Richard A.; Dworkin, Samuel F.; Amtmann, Dagmar; Andersson, Gunnar; Borenstein, David; Carragee, Eugene; Carrino, John; Chou, Roger; Cook, Karon; DeLitto, Anthony; Goertz, Christine; Khalsa, Partap; Loeser, John; Mackey, Sean; Panagis, James; Rainville, James; Tosteson, Tor; Turk, Dennis; Von Korff, Michael; Weiner, Debra K.

    2014-01-01

    Despite rapidly increasing intervention, functional disability due to chronic low back pain (cLBP) has increased in recent decades. We often cannot identify mechanisms to explain the major negative impact cLBP has on patients’ lives. Such cLBP is often termed non-specific, and may be due to multiple biologic and behavioral etiologies. Researchers use varied inclusion criteria, definitions, baseline assessments, and outcome measures, which impede comparisons and consensus. The NIH Pain Consortium therefore charged a Research Task Force (RTF) to draft standards for research on cLBP. The resulting multidisciplinary panel recommended using 2 questions to define cLBP; classifying cLBP by its impact (defined by pain intensity, pain interference, and physical function); use of a minimal data set to describe research participants (drawing heavily on the PROMIS methodology); reporting “responder analyses” in addition to mean outcome scores; and suggestions for future research and dissemination. The Pain Consortium has approved the recommendations, which investigators should incorporate into NIH grant proposals. The RTF believes these recommendations will advance the field, help to resolve controversies, and facilitate future research addressing the genomic, neurologic, and other mechanistic substrates of chronic low back pain. We expect the RTF recommendations will become a dynamic document, and undergo continual improvement. Perspective A Task Force was convened by the NIH Pain Consortium, with the goal of developing research standards for chronic low back pain. The results included recommendations for definitions, a minimal dataset, reporting outcomes, and future research. Greater consistency in reporting should facilitate comparisons among studies and the development of phenotypes. PMID:24787228

  18. Report of the NIH Task Force on Research Standards for Chronic Low Back Pain†

    PubMed Central

    Deyo, Richard A.; Dworkin, Samuel F.; Amtmann, Dagmar; Andersson, Gunnar; Borenstein, David; Carragee, Eugene; Carrino, John; Chou, Roger; Cook, Karon; DeLitto, Anthony; Goertz, Christine; Khalsa, Partap; Loeser, John; Mackey, Sean; Panagis, James; Rainville, James; Tosteson, Tor; Turk, Dennis; Von Korff, Michael; Weiner, Debra K.

    2015-01-01

    Despite rapidly increasing intervention, functional disability due to chronic low back pain (cLBP) has increased in recent decades. We often cannot identify mechanisms to explain the major negative impact cLBP has on patients’ lives. Such cLBP is often termed non-specific, and may be due to multiple biologic and behavioral etiologies. Researchers use varied inclusion criteria, definitions, baseline assessments, and outcome measures, which impede comparisons and consensus. The NIH Pain Consortium therefore charged a Research Task Force (RTF) to draft standards for research on cLBP. The resulting multidisciplinary panel recommended using 2 questions to define cLBP; classifying cLBP by its impact (defined by pain intensity, pain interference, and physical function); use of a minimal data set to describe research participants (drawing heavily on the PROMIS methodology); reporting “responder analyses” in addition to mean outcome scores; and suggestions for future research and dissemination. The Pain Consortium has approved the recommendations, which investigators should incorporate into NIH grant proposals. The RTF believes these recommendations will advance the field, help to resolve controversies, and facilitate future research addressing the genomic, neurologic, and other mechanistic substrates of chronic low back pain. We expect the RTF recommendations will become a dynamic document, and undergo continual improvement. Perspective A Task Force was convened by the NIH Pain Consortium, with the goal of developing research standards for chronic low back pain. The results included recommendations for definitions, a minimal dataset, reporting outcomes, and future research. Greater consistency in reporting should facilitate comparisons among studies and the development of phenotypes. PMID:26388962

  19. Animal-Assisted Therapy for Patients Undergoing Treatment at NIH Clinical Center | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. Feature: Therapy Dogs Animal-Assisted Therapy for Patients Undergoing Treatment at NIH Clinical Center ... She and her friendly beagle, Juno, are trusted animal-assisted therapy volunteers. Accompanied by Parker or other Clinical Center ...

  20. NIH Research: “The public wants diseases cured...” | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. NIH Research: “The public wants diseases cured...” Past Issues / Fall 2011 ... steroids to patient-specific action plans.” What are the challenges of research? Dr. Metcalfe: You have to ...

  1. Resource Manual

    ERIC Educational Resources Information Center

    Human Development Institute, 2008

    2008-01-01

    This manual was designed primarily for use by individuals with developmental disabilities and related conditions. The main focus of this manual is to provide easy-to-read information concerning available resources, and to provide immediate contact information for the purpose of applying for resources and/or locating additional information. The…

  2. Reliability study of the NiH2 strain gage

    NASA Technical Reports Server (NTRS)

    Klein, Glenn C.; Rash, Donald E., Jr.

    1993-01-01

    This paper summarizes a joint study by Gates Aerospace Batteries (GAB) and the Reliability Analysis Center (RAC). This study characterizes the reliability and robustness of the temperature compensated strain gages currently specified for sensing of internal pressure of NiH2 cells. These strain gages are characterized as fully encapsulated, metallic foil grids with known resistance that varies with deformation. The measurable deformation, when typically installed on the hemispherical portion of a NiH2 cell, is proportional to the material stresses as generated by internal cell pressures. The internal pressure sensed in this manner is calibrated to indicate the state-of-charge for the cell. This study analyzes and assesses both robustness and reliability for the basic design of the strain gage, the installation of the strain gage, and the circuitry involved.

  3. Grantsmanship Resources

    Cancer.gov

    Grants-related information is available to scientists and institutional science management officials about NIH and NCI funding and scientific review policies and procedures, preparation of grant applications, and funding instruments.

  4. Writing a Successful NIH Mentored Career Development Grant (K Award)

    PubMed Central

    Brock, Malcolm V.; Bouvet, Michael

    2014-01-01

    Surgery is a labor-intensive, time-consuming profession. Young faculty members in surgery are saddled with many clinical time constraints that often allow precious few moments for academic pursuits. Consequently, K award submissions from surgeons trail nonsurgeons. The National Institutes of Health (NIH), however, is actively trying to encourage participation of surgeons in basic science research, translational research, clinical outcomes research, and even in prevention/control research. But, at the same time, the NIH has newly implemented a policy that has made the grant review process more restrictive by only allowing 2 submissions of any grant application. It is imperative, therefore, for junior faculty surgeons to learn “grantsmanship” and have the ability to construct succinct, competitive K award grants. Although most of this information is public knowledge and made available by the NIH itself, many of the practical points presented here are tailored to the special needs of clinically active surgical researchers. Often, these “hints” are buried on expansive websites that require considerable time to read and navigate. The authors have a long combined experience on a study section dedicated to adjudicating K awards. The goal of this review is to present concise, useful information about common errors, research plan dos and don’ts, template examples of superior mentored letters, and many other suggestions that may assist any first-time candidate for these awards. PMID:20485135

  5. Public Access and Use of Health Research: An Exploratory Study of the National Institutes of Health (NIH) Public Access Policy Using Interviews and Surveys of Health Personnel

    PubMed Central

    Willinsky, John; Maggio, Lauren

    2011-01-01

    Background In 2008, the National Institutes of Health (NIH) Public Access Policy mandated open access for publications resulting from NIH funding (following a 12-month embargo). The large increase in access to research that will take place in the years to come has potential implications for evidence-based practice (EBP) and lifelong learning for health personnel. Objective This study assesses health personnel’s current use of research to establish whether grounds exist for expecting, preparing for, and further measuring the impact of the NIH Public Access Policy on health care quality and outcomes in light of time constraints and existing information resources. Methods In all, 14 interviews and 90 surveys of health personnel were conducted at a community-based clinic and an independent teaching hospital in 2010. Health personnel were asked about the research sources they consulted and the frequency with which they consulted these sources, as well as motivation and search strategies used to locate articles, perceived level of access to research, and knowledge of the NIH Public Access Policy. Results In terms of current access to health information, 65% (57/88) of the health personnel reported being satisfied, while 32% (28/88) reported feeling underserved. Among the sources health personnel reported that they relied upon and consulted weekly, 83% (73/88) reported turning to colleagues, 77% (67/87) reported using synthesized information resources (eg, UpToDate and Cochrane Systematic Reviews), while 32% (28/88) reported that they consulted primary research literature. The dominant resources health personnel consulted when actively searching for health information were Google and Wikipedia, while 27% (24/89) reported using PubMed weekly. The most prevalent reason given for accessing research on a weekly basis, reported by 35% (31/88) of survey respondents, was to help a specific patient, while 31% (26/84) were motivated by general interest in research. Conclusions

  6. Food additives

    MedlinePlus

    Food additives are substances that become part of a food product when they are added during the processing or making of that food. "Direct" food additives are often added during processing to: Add nutrients ...

  7. Food additives

    PubMed Central

    Spencer, Michael

    1974-01-01

    Food additives are discussed from the food technology point of view. The reasons for their use are summarized: (1) to protect food from chemical and microbiological attack; (2) to even out seasonal supplies; (3) to improve their eating quality; (4) to improve their nutritional value. The various types of food additives are considered, e.g. colours, flavours, emulsifiers, bread and flour additives, preservatives, and nutritional additives. The paper concludes with consideration of those circumstances in which the use of additives is (a) justified and (b) unjustified. PMID:4467857

  8. Database resources of the National Center for Biotechnology Information: update.

    PubMed

    Wheeler, David L; Church, Deanna M; Edgar, Ron; Federhen, Scott; Helmberg, Wolfgang; Madden, Thomas L; Pontius, Joan U; Schuler, Gregory D; Schriml, Lynn M; Sequeira, Edwin; Suzek, Tugba O; Tatusova, Tatiana A; Wagner, Lukas

    2004-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's website. NCBI resources include Entrez, PubMed, PubMed Central, LocusLink, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SARS Coronavirus Resource, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. PMID:14681353

  9. Database resources of the National Center for Biotechnology Information.

    PubMed

    Wheeler, David L; Barrett, Tanya; Benson, Dennis A; Bryant, Stephen H; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M; Dicuccio, Michael; Edgar, Ron; Federhen, Scott; Feolo, Michael; Geer, Lewis Y; Helmberg, Wolfgang; Kapustin, Yuri; Khovayko, Oleg; Landsman, David; Lipman, David J; Madden, Thomas L; Maglott, Donna R; Miller, Vadim; Ostell, James; Pruitt, Kim D; Schuler, Gregory D; Shumway, Martin; Sequeira, Edwin; Sherry, Steven T; Sirotkin, Karl; Souvorov, Alexandre; Starchenko, Grigory; Tatusov, Roman L; Tatusova, Tatiana A; Wagner, Lukas; Yaschenko, Eugene

    2008-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data available through NCBI's web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace, Assembly, and Short Read Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Database of Genotype and Phenotype, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting the web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:18045790

  10. Database resources of the National Center for Biotechnology Information.

    PubMed

    Wheeler, David L; Barrett, Tanya; Benson, Dennis A; Bryant, Stephen H; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Geer, Lewis Y; Kapustin, Yuri; Khovayko, Oleg; Landsman, David; Lipman, David J; Madden, Thomas L; Maglott, Donna R; Ostell, James; Miller, Vadim; Pruitt, Kim D; Schuler, Gregory D; Sequeira, Edwin; Sherry, Steven T; Sirotkin, Karl; Souvorov, Alexandre; Starchenko, Grigory; Tatusov, Roman L; Tatusova, Tatiana A; Wagner, Lukas; Yaschenko, Eugene

    2007-01-01

    In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link(BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace and Assembly Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Viral Genotyping Tools, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:17170002

  11. Database resources of the National Center for Biotechnology Information: update

    PubMed Central

    Wheeler, David L.; Church, Deanna M.; Edgar, Ron; Federhen, Scott; Helmberg, Wolfgang; Madden, Thomas L.; Pontius, Joan U.; Schuler, Gregory D.; Schriml, Lynn M.; Sequeira, Edwin; Suzek, Tugba O.; Tatusova, Tatiana A.; Wagner, Lukas

    2004-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI’s website. NCBI resources include Entrez, PubMed, PubMed Central, LocusLink, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SARS Coronavirus Resource, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. PMID:14681353

  12. Transformation of human cells by DNAs ineffective in transformation of NIH 3T3 cells

    SciTech Connect

    Sutherland, B.M.; Bennett, P.B.; Freeman, A.G.; Moore, S.P.; Strickland, P.T.

    1985-04-01

    Neonatal human foreskin fibroblasts can be transformed to anchorage-independent growth by transfection with DNAs inefficient in transforming NIH 3T3 cells. Human cells transfected with DNA from GM 1312, a multiple myeloma cell line, or MOLT-4, a permanent lymphoblast line, grow without anchorage at a much higher frequency than do the parental cells and their DNAs can transform human cell recipients to anchorage-independent growth; they have extended but not indefinite life spans and are nontumorigenic. Human fibroblasts are also transformed by DNAs from two multiple myeloma lines that also transform 3T3 cells; however, restriction analysis suggests that different transforming genes in this DNA are acting in the human and murine systems. These results indicate that the human cell transfection system allows detection of transforming genes not effective in the 3T3 system and points out the possibility of detection of additional transforming sequences even in DNAs that do transform murine cells.

  13. The art and science of integrating Undoing Racism with CBPR: challenges of pursuing NIH funding to investigate cancer care and racial equity.

    PubMed

    Yonas, Michael A; Jones, Nora; Eng, Eugenia; Vines, Anissa I; Aronson, Robert; Griffith, Derek M; White, Brandolyn; DuBose, Melvin

    2006-11-01

    In this nation, the unequal burden of disease among People of Color has been well documented. One starting point to eliminating health disparities is recognizing the existence of inequities in health care delivery and identifying the complexities of how institutional racism may operate within the health care system. In this paper, we explore the integration of community-based participatory research (CBPR) principles with an Undoing Racism process to conceptualize, design, apply for, and secure National Institutes of Health (NIH) funding to investigate the complexities of racial equity in the system of breast cancer care. Additionally, we describe the sequence of activities and "necessary conflicts" managed by our Health Disparities Collaborative to design and submit an application for NIH funding. This process of integrating CBPR principles with anti-racist community organizing presented unique challenges that were negotiated only by creating a strong foundation of trusting relationships that viewed conflict as being necessary. The process of developing a successful NIH grant proposal illustrated a variety of important lessons associated with the concepts of cultural humility and cultural safety. For successfully conducting CBPR, major challenges have included: assembling and mobilizing a partnership; the difficulty of establishing a shared vision and purpose for the group; the problem of maintaining trust; and the willingness to address differences in institutional cultures. Expectation, acceptance and negotiation of conflict were essential in the process of developing, preparing and submitting our NIH application. Central to negotiating these and other challenges has been the utilization of a CBPR approach. PMID:17072760

  14. Resource Economics

    NASA Astrophysics Data System (ADS)

    Conrad, Jon M.

    1999-10-01

    Resource Economics is a text for students with a background in calculus, intermediate microeconomics, and a familiarity with the spreadsheet software Excel. The book covers basic concepts, shows how to set up spreadsheets to solve dynamic allocation problems, and presents economic models for fisheries, forestry, nonrenewable resources, stock pollutants, option value, and sustainable development. Within the text, numerical examples are posed and solved using Excel's Solver. Through these examples and additional exercises at the end of each chapter, students can make dynamic models operational, develop their economic intuition, and learn how to set up spreadsheets for the simulation of optimization of resource and environmental systems.

  15. The Pilot Phase of the NIH Chemical Genomics Center

    PubMed Central

    Thomas, Craig J.; Auld, Douglas S.; Huang, Ruili; Huang, Wenwei; Jadhav, Ajit; Johnson, Ronald L.; Leister, William; Maloney, David J.; Marugan, Juan J.; Michael, Sam; Simeonov, Anton; Southall, Noel; Xia, Menghang; Zheng, Wei; Inglese, James; Austin, Christopher P.

    2010-01-01

    The NIH Chemical Genomics Center (NCGC) was the inaugural center of the Molecular Libraries and Screening Center Network (MLSCN). Along with the nine other research centers of the MLSCN, the NCGC was established with a primary goal of bringing industrial technology and experience to empower the scientific community with small molecule compounds for use in their research. We intend this review to serve as 1) an introduction to the NCGC standard operating procedures, 2) an overview of several of the lessons learned during the pilot phase and 3) a review of several of the innovative discoveries reported during the pilot phase of the MLSCN. PMID:19807664

  16. Food additives.

    PubMed

    Berglund, F

    1978-01-01

    The use of additives to food fulfils many purposes, as shown by the index issued by the Codex Committee on Food Additives: Acids, bases and salts; Preservatives, Antioxidants and antioxidant synergists; Anticaking agents; Colours; Emulfifiers; Thickening agents; Flour-treatment agents; Extraction solvents; Carrier solvents; Flavours (synthetic); Flavour enhancers; Non-nutritive sweeteners; Processing aids; Enzyme preparations. Many additives occur naturally in foods, but this does not exclude toxicity at higher levels. Some food additives are nutrients, or even essential nutritents, e.g. NaCl. Examples are known of food additives causing toxicity in man even when used according to regulations, e.g. cobalt in beer. In other instances, poisoning has been due to carry-over, e.g. by nitrate in cheese whey - when used for artificial feed for infants. Poisonings also occur as the result of the permitted substance being added at too high levels, by accident or carelessness, e.g. nitrite in fish. Finally, there are examples of hypersensitivity to food additives, e.g. to tartrazine and other food colours. The toxicological evaluation, based on animal feeding studies, may be complicated by impurities, e.g. orthotoluene-sulfonamide in saccharin; by transformation or disappearance of the additive in food processing in storage, e.g. bisulfite in raisins; by reaction products with food constituents, e.g. formation of ethylurethane from diethyl pyrocarbonate; by metabolic transformation products, e.g. formation in the gut of cyclohexylamine from cyclamate. Metabolic end products may differ in experimental animals and in man: guanylic acid and inosinic acid are metabolized to allantoin in the rat but to uric acid in man. The magnitude of the safety margin in man of the Acceptable Daily Intake (ADI) is not identical to the "safety factor" used when calculating the ADI. The symptoms of Chinese Restaurant Syndrome, although not hazardous, furthermore illustrate that the whole ADI

  17. NIH Research: Dr. Anthony S. Fauci: "An AIDS-free generation is closer than we might think" | NIH MedlinePlus the ...

    MedlinePlus

    ... Javascript on. NIH Research: Dr. Anthony S. Fauci: "An AIDS-free generation is closer than we might think" ... Washington Post . What's the current state of the AIDS epidemic? The number of people contracting HIV infection ...

  18. Space Station Freedom NiH2 cell testing program

    NASA Technical Reports Server (NTRS)

    Moore, Bruce; Frate, Dave

    1994-01-01

    Testing for the Space Station Freedom Nickel Hydrogen Cell Test Program began in 1990 at Crave Division, Naval Surface Warfare Center. The program has included receipt inspection, random vibration, acceptance, characterization, and life cycle testing of Ni-H2 cells in accordance with the NASA LeRC Interagency Order C-31001-J. A total of 400 Ni-H2 cells have been received at NAVSURFWARCENDIV Crane from three separate manufacturers; Yardney Technical Products (Yardney), Eagle Picher Industries (Eagle Picher), and Gates Energy Products (Gates). Of those, 308 cells distributed among 39 packs have undergone life cycle testing under a test regime simulating low earth orbit conditions. As of 30 September 1993, there are 252 cells assembled into 32 packs still on life cycle test. Since the beginning of the program, failed cells have been detected in all phases of testing. The failures include the following; seven 65 AmpHr and 81 AmpHr Yardney cells were found to be leaking KOH on receipt, one 65 AmpHr Eagle Picher cell failed the acceptance test, one 65 AmpHr Gates cell failed during the characterization test, and six 65 AmpHr Gates cells failed the random vibration test. Of the 39 life cycle packs, testing on seven packs, 56 cells, has been suspended because of low end of discharge voltages. All of the failed life cycle packs were cycled at 60% depth of discharge.

  19. Space Station Freedom NiH2 cell testing program

    NASA Astrophysics Data System (ADS)

    Moore, Bruce; Frate, Dave

    1994-02-01

    Testing for the Space Station Freedom Nickel Hydrogen Cell Test Program began in 1990 at Crave Division, Naval Surface Warfare Center. The program has included receipt inspection, random vibration, acceptance, characterization, and life cycle testing of Ni-H2 cells in accordance with the NASA LeRC Interagency Order C-31001-J. A total of 400 Ni-H2 cells have been received at NAVSURFWARCENDIV Crane from three separate manufacturers; Yardney Technical Products (Yardney), Eagle Picher Industries (Eagle Picher), and Gates Energy Products (Gates). Of those, 308 cells distributed among 39 packs have undergone life cycle testing under a test regime simulating low earth orbit conditions. As of 30 September 1993, there are 252 cells assembled into 32 packs still on life cycle test. Since the beginning of the program, failed cells have been detected in all phases of testing. The failures include the following; seven 65 AmpHr and 81 AmpHr Yardney cells were found to be leaking KOH on receipt, one 65 AmpHr Eagle Picher cell failed the acceptance test, one 65 AmpHr Gates cell failed during the characterization test, and six 65 AmpHr Gates cells failed the random vibration test. Of the 39 life cycle packs, testing on seven packs, 56 cells, has been suspended because of low end of discharge voltages. All of the failed life cycle packs were cycled at 60% depth of discharge.

  20. Language measures of the NIH Toolbox Cognition Battery.

    PubMed

    Gershon, Richard C; Cook, Karon F; Mungas, Dan; Manly, Jennifer J; Slotkin, Jerry; Beaumont, Jennifer L; Weintraub, Sandra

    2014-07-01

    Language facilitates communication and efficient encoding of thought and experience. Because of its essential role in early childhood development, in educational achievement and in subsequent life adaptation, language was included as one of the subdomains in the NIH Toolbox for the Assessment of Neurological and Behavioral Function Cognition Battery (NIHTB-CB). There are many different components of language functioning, including syntactic processing (i.e., morphology and grammar) and lexical semantics. For purposes of the NIHTB-CB, two tests of language--a picture vocabulary test and a reading recognition test--were selected by consensus based on literature reviews, iterative expert input, and a desire to assess in English and Spanish. NIHTB-CB's picture vocabulary and reading recognition tests are administered using computer adaptive testing and scored using item response theory. Data are presented from the validation of the English versions in a sample of adults ages 20-85 years (Spanish results will be presented in a future publication). Both tests demonstrated high test-retest reliability and good construct validity compared to corresponding gold-standard measures. Scores on the NIH Toolbox measures were consistent with age-related expectations, namely, growth in language during early development, with relative stabilization into late adulthood. PMID:24960128

  1. The rising cost of NIH-funded biomedical research?

    PubMed

    Kennedy, T J

    1990-02-01

    During the last decade, total appropriations for the NIH have grown in current as well as constant dollars. Constant dollar expenditures for indirect costs and research project grants have increased, as also has the number of the latter, while such expenditures for research centers, training, and research contracts have shrunk. The most impressive redistribution in emphasis has been toward traditional research project grants (R01s). The size of the average R01 award, discounted for inflation, has grown at an annual rate of 1.1% during the last decade and 1.3% since fiscal year (FY) 1970; that of the average research program project (P01) has declined over the same periods, after a slight rise in the early 1970s. Factors contributing to the modest rise in the real (constant-dollar) size of the average R01 are explored. The regularity with which current-services-requirements estimates for the NIH exceed inflation reflects real growth in the program, particularly in the category of research project grants; the artifact of basing calculations on the post-rather than pre-"negotiated" levels of awards in the "current" year; and the extent to which the project periods of awards have been extended. The effect of lengthening project periods is slow to become manifest, but inexorably swells the pool of non-competing awards; decisions in this area undertaken in 1985, and continued at least through FY 1988, could very significantly increase current services requirements in FYs 1991 and 1992. PMID:2302301

  2. 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research | Division of Cancer Prevention

    Cancer.gov

    The NIH Pain Consortium will convene the 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research, featuring keynote speakers and expert panel sessions on Innovative Models and Methods. The first keynote address will be delivered by David J. Clark, MD, PhD, Stanford University entitled “Challenges of Translational Pain Research: What Makes a Good Model?” |

  3. On the Front Lines of Rare Disease Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... and Translational Science Awards Program. Find Out More National Center for Advancing Translational Sciences (NCATS): https://ncats.nih.gov/ MedlinePlus: www.nlm.nih.gov/medlineplus/rarediseases.html Rare Disease United Foundation: rarediseaseunited.org How important is medical research on ...

  4. 75 FR 15710 - Submission for OMB Review; Comment Request; Process Evaluation of the NIH's Roadmap...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... control number. Proposed Collection: The National Institute of Dental and Craniofacial Research of the National Institutes of Heath requests a two-year clearance for Title: ``Process Evaluation of the NIH... Institute of Dental and Craniofacial Research (NIDCR), NIH. You may reach Dr. Hamann by telephone on...

  5. 76 FR 44339 - Office of Biotechnology Activities; Recombinant DNA Research: Action Under the NIH Guidelines for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... HUMAN SERVICES National Institutes of Health Office of Biotechnology Activities; Recombinant DNA Research: Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines... attenuated strains of bacteria and viruses that are frequently used in recombinant DNA research. OBA is...

  6. NIH Study Provides Clarity on Supplements for Protection Against Blinding Eye Disease

    MedlinePlus

    ... for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov . NIH…Turning Discovery Into Health ® References AREDS2 Research Group. “Lutein/Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration. The Age-Related Eye Disease ...

  7. Symptoms, Causes, Diagnosis, and Treatment of Lupus | NIH MedlinePlus the Magazine

    MedlinePlus

    ... box NIH Accelerating Medicines Partnership www.nih.gov/science/amp/index.htm Lupus Foundation of America (LFA) and Julian Lennon www.lupus.org www.lupus.org/lennon American College of Rheumatology www.rheumatology.org Alliance for Lupus Research, Inc www.lupusresearch.org Lupus ...

  8. Beyond Patents and Royalties: Perception and Reality of Doing Business with the NIH

    PubMed Central

    Ben-Menachem, Gil; Ferguson, Steven M.; Balakrishnan, Krishna

    2009-01-01

    Young, and mid size biotech companies can benefit hugely from the US National Institutes of Health (NIH), not least because of the agency's non-dilutive funding, guidance, and opportunities for collaboration. Increasingly, however, there is a fair bit of misunderstanding about what the NIH can and cannot do for a biotech entrepreneur. PMID:19779601

  9. Hubris in Grantland: Languor and Laissez-faire Greet Conflict of Interest at the NIH

    ERIC Educational Resources Information Center

    Greenberg, Daniel S.

    2010-01-01

    New rules are coming for sanitizing conflicts of interest in research financed by the National Institutes of Health (NIH), dispenser of the government's biggest budget for civilian science, some $31 billion this year. The conflicted need not fear. The draft rules, soon to be made final, continue the NIH's longtime practice of trust but don't…

  10. The Brain Takes Center Stage at 2014 NIH Research Festival | Poster

    Cancer.gov

    By Andrea Frydl, Contributing Writer The 2014 NIH Research Festival, Sept. 22–24, focused on the human brain for two, very specific, reasons: to coincide with the White House BRAIN Initiative and to highlight the John Edward Porter Neuroscience Research Center, which opened earlier this year on the NIH campus.

  11. Welcome from Library Director Donald A.B. Lindberg, M.D. | NIH MedlinePlus the Magazine

    MedlinePlus

    ... http://m.medlineplus.gov/spanish Tune in: NIH Radio Free podcast audio reports on your computer or personal audio player www.nih.gov/news/radio/nihpodcast.htm Spring 2013 Issue: Volume 8 Number ...

  12. All in the Family: When High Blood Cholesterol Occurs in Families | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Program booklet: www.nhlbi.nih.gov/health/public/heart/chol/wyntk.pdf What You Need To Know About High Blood Cholesterol www.nhlbi.nih.gov/health/public/heart/chol/cholesterol_atglance.htm Your Guide to Lowering ...

  13. Regulation of p53 in NIH3T3 mouse fibroblasts following hyperosmotic stress.

    PubMed

    Lambert, Ian Henry; Enghoff, Maria Stine; Brandi, Marie-Luise; Hoffmann, Else Kay

    2015-06-01

    The aim of this project was to analyze the regulation of p53 expression in NIH3T3 fibroblasts under the influence of increasing hyperosmotic stress. Expression of p53 showed a biphasic response pattern in NIH3T3 cells under increasing osmotic stress (337 mOsm to 737 mOsm) with a maximum at 587 mOsm. Under isotonic conditions p53 expression increased after addition of the proteasome inhibitor MG132 indicating that cellular p53 levels in unperturbed cells is kept low by proteasomal degradation. However, under hypertonic conditions p53 synthesis as well as p53 degradation were significantly reduced and it is demonstrated that the increase in p53 expression observed when tonicity is increased from 337 to 587 mOsm reflects that degradation is more inhibited than synthesis, whereas the decrease in p53 expression at higher tonicities reflects that synthesis is more inhibited than degradation. The activity of the p53 regulating proteins p38 MAP kinase and the ubiquitin ligase MDM2 were studied as a function of increasing osmolarity. MDM2 protein expression was unchanged at all osmolarities, whereas MDM2 phosphorylation (Ser(166)) increased at osmolarities up to 537 mOsm and remained constant at higher osmolarities. Phosphorylation of p38 increased at osmolarities up to 687 mOsm which correlated with an increased phosphorylation of p53 (Ser(15)) and the decreased p53 degradation. Caspase-3 activity increased gradually with hypertonicity and at 737 mOsm both Caspase-3 activity and annexin V binding are high even though p53 expression and activity are low, indicating that initiation of apoptosis under severe hypertonic conditions is not strictly controlled by p53. PMID:26056062

  14. Estimates of intakes and internal doses from ingestion of {sup 32}P at MIT and NIH

    SciTech Connect

    Stabin, M.G.; Toohey, R.E.

    1996-06-01

    A researcher at Massachusetts Institute of Technology (MIT) became internally contaminated with {sup 32}P, probably due to an intentional act. The incident occurred on or about 14 August 1995. Subsequent measurement of activity in urine and a single whole body count were used to estimate the individual`s intake, with the assumption of ingestion as the route of intake. Two separate Sets of urine data were analyzed-one supplied by MIT and one from independent analyses of urine samples conducted at Oak Ridge Institute for Science and Education (ORISE); the former data set contained 35 samples, the latter 49. In addition, the results of 35 whole body counts, provided by MIT from a chair-type counter calibrated for 32p, were used to obtain a separate estimate of intake. The kinetic model for 32P proposed in ICRP Publication 30 and implemented in NUREG/CR-4884 was used to interpret the data. The data were analyzed using both the weighted and unweighted least squares techniques. All of the intake estimates were in very good agreement with each other, ranging from 18-22 MBq. Based on the dose model in ICRP 30, this would indicate a committed effective dose equivalent of 38-46 mSv. The incident was helpful in assessing the value of the least squares techniques in determining estimates of intake and dose. The ICRP model tended to slightly overestimate the whole body retention data and underestimate the urinary excretion at later times. Further results obtained by visual best fit and development of an individual-specific kinetic and dose model will also be discussed. This incident was quite similar to another case of ingestion of 32p that occurred at the National Institute of Health (NIH) on 28 June 1995. Dose assessment for the NIH case will also be presented if the data are available for public release.

  15. Regulation of p53 in NIH3T3 mouse fibroblasts following hyperosmotic stress

    PubMed Central

    Lambert, Ian Henry; Enghoff, Maria Stine; Brandi, Marie-Luise; Hoffmann, Else Kay

    2015-01-01

    The aim of this project was to analyze the regulation of p53 expression in NIH3T3 fibroblasts under the influence of increasing hyperosmotic stress. Expression of p53 showed a biphasic response pattern in NIH3T3 cells under increasing osmotic stress (337 mOsm to 737 mOsm) with a maximum at 587 mOsm. Under isotonic conditions p53 expression increased after addition of the proteasome inhibitor MG132 indicating that cellular p53 levels in unperturbed cells is kept low by proteasomal degradation. However, under hypertonic conditions p53 synthesis as well as p53 degradation were significantly reduced and it is demonstrated that the increase in p53 expression observed when tonicity is increased from 337 to 587 mOsm reflects that degradation is more inhibited than synthesis, whereas the decrease in p53 expression at higher tonicities reflects that synthesis is more inhibited than degradation. The activity of the p53 regulating proteins p38 MAP kinase and the ubiquitin ligase MDM2 were studied as a function of increasing osmolarity. MDM2 protein expression was unchanged at all osmolarities, whereas MDM2 phosphorylation (Ser166) increased at osmolarities up to 537 mOsm and remained constant at higher osmolarities. Phosphorylation of p38 increased at osmolarities up to 687 mOsm which correlated with an increased phosphorylation of p53 (Ser15) and the decreased p53 degradation. Caspase-3 activity increased gradually with hypertonicity and at 737 mOsm both Caspase-3 activity and annexin V binding are high even though p53 expression and activity are low, indicating that initiation of apoptosis under severe hypertonic conditions is not strictly controlled by p53. PMID:26056062

  16. The challenge for NIH ethics policies: preserving public trust and biomedical progress.

    PubMed

    Bravo, Norka Ruiz

    2007-03-01

    Recently updated ethics rules for employees of the National Institutes of Health (NIH) aim to prevent inappropriate influences on research decisions while preserving employees' professional and scientific interactions. Specific provisions require NIH employees to report their financial holdings in "substantially affected organizations" and require senior employees to divest all holdings greater than $15,000 in any single such organization. Outside institutions that receive NIH grants are bound by separate disclosure requirements. Public-private partnerships have become more important to NIH efforts to advance biomedical research in light of flat NIH budgets in recent years. Such partnerships open the door, however, to financial conflicts that must be prevented or managed in order to maintain scientific integrity and public trust. PMID:17469471

  17. Lost in Translation: NIH Funding for Family Medicine Research Remains Limited.

    PubMed

    Cameron, Brianna J; Bazemore, Andrew W; Morley, Christopher P

    2016-01-01

    Departments of Family Medicine (DFMs) in the United States consistently received around 0.2% of total research funding dollars and 0.3% of all awards awarded by the National Institutes of Health (NIH) across the years 2002 to 2014. We used the NIH Reporter tool to quantify the amount of funding and the number of grants received by DFMs from the NIH from 2002 to 2014, using criteria similar to those applied by previous researchers. NIH funding to DFMs as remained fairly consistent across the time period, at roughly 0.2% of total NIH funding and 0.3% of total grants awarded. Changing these proportions will likely require considerable effort to build research capacity within DFMs and their frontline practice research networks, and to shift policymaker and funder perceptions of the value of the FM research enterprise. PMID:27613784

  18. Gene expression in amygdala as a function of differential trait anxiety levels in genetically heterogeneous NIH-HS rats.

    PubMed

    Díaz-Morán, Sira; Palència, Marta; Mont-Cardona, Carme; Cañete, Toni; Blázquez, Gloria; Martínez-Membrives, Esther; López-Aumatell, Regina; Sabariego, Marta; Donaire, Rocío; Morón, Ignacio; Torres, Carmen; Martínez-Conejero, José Antonio; Tobeña, Adolf; Esteban, Francisco José; Fernández-Teruel, Alberto

    2013-09-01

    To identify genes involved in anxiety/fear traits, we analyzed the gene expression profile in the amygdala of genetically heterogeneous NIH-HS rats. The NIH-HS rat stock has revealed to be a unique genetic resource for the fine mapping of Quantitative Trait Loci (QTLs) to very small genomic regions, due to the high amount of genetic recombinants accumulated along more than 50 breeding generations, and for the same reason it can be expected that those genetically heterogeneous rats should be especially useful for studying differential gene expression as a function of anxiety-(or other)-related traits. We selected high- and low-anxious NIH-HS rats differing in their number of avoidances in a single 50-trial session of the two-way active avoidance task. Rats were also tested in unconditioned anxiety tests (e.g., elevated zero-maze). Three weeks after behavioural testing, the amygdala was dissected and prepared for the microarray study. There appeared 6 significantly down-regulated and 28 up-regulated genes (fold-change >|2|, FDR<0.05) between the low- and high-anxious groups, with central nervous system-related functions. Regression analyses (stepwise) revealed that differential expression of some genes could be predictive of anxiety/fear responses. Among those genes for which the present results suggest a link with individual differences in trait anxiety, six relevant genes were examined with qRT-PCR, four of which (Ucn3, Tacr3, H2-M9 and Arr3) were validated. Remarkably, some of them are characterized by sharing known functions related with hormonal HPA-axis responses to (and/or modulation of) stress, anxiety or fear, and putative involvement in related neurobehavioural functions. The results confirm the usefulness of NIH-HS rats as a good animal model for research on the neurogenetic basis of anxiety and fear, while suggesting the involvement of some neuropeptide/neuroendocrine pathways on the development of differential anxiety profiles. PMID:23777796

  19. Guidance from an NIH Workshop on Designing, Implementing, and Reporting Clinical Studies of Soy Interventions1–4

    PubMed Central

    Klein, Marguerite A.; Nahin, Richard L.; Messina, Mark J.; Rader, Jeanne I.; Thompson, Lilian U.; Badger, Thomas M.; Dwyer, Johanna T.; Kim, Young S.; Pontzer, Carol H.; Starke-Reed, Pamela E.; Weaver, Connie M.

    2010-01-01

    The NIH sponsored a scientific workshop, “Soy Protein/Isoflavone Research: Challenges in Designing and Evaluating Intervention Studies,” July 28–29, 2009. The workshop goal was to provide guidance for the next generation of soy protein/isoflavone human research. Session topics included population exposure to soy; the variability of the human response to soy; product composition; methods, tools, and resources available to estimate exposure and protocol adherence; and analytical methods to assess soy in foods and supplements and analytes in biologic fluids and other tissues. The intent of the workshop was to address the quality of soy studies, not the efficacy or safety of soy. Prior NIH workshops and an evidence-based review questioned the quality of data from human soy studies. If clinical studies are pursued, investigators need to ensure that the experimental designs are optimal and the studies properly executed. The workshop participants identified methodological issues that may confound study results and interpretation. Scientifically sound and useful options for dealing with these issues were discussed. The resulting guidance is presented in this document with a brief rationale. The guidance is specific to soy clinical research and does not address nonsoy-related factors that should also be considered in designing and reporting clinical studies. This guidance may be used by investigators, journal editors, study sponsors, and protocol reviewers for a variety of purposes, including designing and implementing trials, reporting results, and interpreting published epidemiological and clinical studies. PMID:20392880

  20. Potlining Additives

    SciTech Connect

    Rudolf Keller

    2004-08-10

    In this project, a concept to improve the performance of aluminum production cells by introducing potlining additives was examined and tested. Boron oxide was added to cathode blocks, and titanium was dissolved in the metal pool; this resulted in the formation of titanium diboride and caused the molten aluminum to wet the carbonaceous cathode surface. Such wetting reportedly leads to operational improvements and extended cell life. In addition, boron oxide suppresses cyanide formation. This final report presents and discusses the results of this project. Substantial economic benefits for the practical implementation of the technology are projected, especially for modern cells with graphitized blocks. For example, with an energy savings of about 5% and an increase in pot life from 1500 to 2500 days, a cost savings of $ 0.023 per pound of aluminum produced is projected for a 200 kA pot.

  1. Phosphazene additives

    SciTech Connect

    Harrup, Mason K; Rollins, Harry W

    2013-11-26

    An additive comprising a phosphazene compound that has at least two reactive functional groups and at least one capping functional group bonded to phosphorus atoms of the phosphazene compound. One of the at least two reactive functional groups is configured to react with cellulose and the other of the at least two reactive functional groups is configured to react with a resin, such as an amine resin of a polycarboxylic acid resin. The at least one capping functional group is selected from the group consisting of a short chain ether group, an alkoxy group, or an aryloxy group. Also disclosed are an additive-resin admixture, a method of treating a wood product, and a wood product.

  2. 78 FR 18613 - Notice of the Implementation of the National Institutes of Health (NIH) Electronic Vendor Invoice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ... Health (NIH) Electronic Vendor Invoice Program (eVIP) SUMMARY: The purpose of this notice is to announce the future implementation of the Electronic Vendor Invoice Program (eVIP) at the National Institutes of Health (NIH) and the planned modification of NIH awards to require vendors to use the eVIP...

  3. 75 FR 54640 - Notice of a Meeting of a Working Group of the NIH Blue Ribbon Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... HUMAN SERVICES National Institutes of Health Notice of a Meeting of a Working Group of the NIH Blue Ribbon Panel The purpose of this notice is to inform the public about a meeting of the NIH Blue Ribbon..., at any time, members of the public may file written comments to the following address: NIH...

  4. Database resources of the National Center for Biotechnology Information

    PubMed Central

    2015-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (Bookshelf, PubMed Central (PMC) and PubReader); medical genetics (ClinVar, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen); genes and genomics (BioProject, BioSample, dbSNP, dbVar, Epigenomics, Gene, Gene Expression Omnibus (GEO), Genome, HomoloGene, the Map Viewer, Nucleotide, PopSet, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser, Trace Archive and UniGene); and proteins and chemicals (Biosystems, COBALT, the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB), Protein Clusters, Protein and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for many of these databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov. PMID:25398906

  5. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Sayers, Eric W.; Barrett, Tanya; Benson, Dennis A.; Bolton, Evan; Bryant, Stephen H.; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M.; DiCuccio, Michael; Federhen, Scott; Feolo, Michael; Geer, Lewis Y.; Helmberg, Wolfgang; Kapustin, Yuri; Landsman, David; Lipman, David J.; Lu, Zhiyong; Madden, Thomas L.; Madej, Tom; Maglott, Donna R.; Marchler-Bauer, Aron; Miller, Vadim; Mizrachi, Ilene; Ostell, James; Panchenko, Anna; Pruitt, Kim D.; Schuler, Gregory D.; Sequeira, Edwin; Sherry, Stephen T.; Shumway, Martin; Sirotkin, Karl; Slotta, Douglas; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A.; Wagner, Lukas; Wang, Yanli; John Wilbur, W.; Yaschenko, Eugene; Ye, Jian

    2010-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, Reference Sequence, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Peptidome, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:19910364

  6. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Sayers, Eric W.; Barrett, Tanya; Benson, Dennis A.; Bolton, Evan; Bryant, Stephen H.; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M.; DiCuccio, Michael; Federhen, Scott; Feolo, Michael; Fingerman, Ian M.; Geer, Lewis Y.; Helmberg, Wolfgang; Kapustin, Yuri; Krasnov, Sergey; Landsman, David; Lipman, David J.; Lu, Zhiyong; Madden, Thomas L.; Madej, Tom; Maglott, Donna R.; Marchler-Bauer, Aron; Miller, Vadim; Karsch-Mizrachi, Ilene; Ostell, James; Panchenko, Anna; Phan, Lon; Pruitt, Kim D.; Schuler, Gregory D.; Sequeira, Edwin; Sherry, Stephen T.; Shumway, Martin; Sirotkin, Karl; Slotta, Douglas; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A.; Wagner, Lukas; Wang, Yanli; Wilbur, W. John; Yaschenko, Eugene; Ye, Jian

    2012-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Website. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Genome and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, BioProject, BioSample, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Probe, Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), Biosystems, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:22140104

  7. Database resources of the National Center for Biotechnology Information

    PubMed Central

    2013-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI, http://www.ncbi.nlm.nih.gov) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, the Genetic Testing Registry, Genome and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, BioProject, BioSample, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Probe, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page. PMID:23193264

  8. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Sayers, Eric W.; Barrett, Tanya; Benson, Dennis A.; Bolton, Evan; Bryant, Stephen H.; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M.; DiCuccio, Michael; Federhen, Scott; Feolo, Michael; Fingerman, Ian M.; Geer, Lewis Y.; Helmberg, Wolfgang; Kapustin, Yuri; Landsman, David; Lipman, David J.; Lu, Zhiyong; Madden, Thomas L.; Madej, Tom; Maglott, Donna R.; Marchler-Bauer, Aron; Miller, Vadim; Mizrachi, Ilene; Ostell, James; Panchenko, Anna; Phan, Lon; Pruitt, Kim D.; Schuler, Gregory D.; Sequeira, Edwin; Sherry, Stephen T.; Shumway, Martin; Sirotkin, Karl; Slotta, Douglas; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A.; Wagner, Lukas; Wang, Yanli; Wilbur, W. John; Yaschenko, Eugene; Ye, Jian

    2011-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Electronic PCR, OrfFinder, Splign, ProSplign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), IBIS, Biosystems, Peptidome, OMSSA, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:21097890

  9. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Acland, Abigail; Agarwala, Richa; Barrett, Tanya; Beck, Jeff; Benson, Dennis A.; Bollin, Colleen; Bolton, Evan; Bryant, Stephen H.; Canese, Kathi; Church, Deanna M.; Clark, Karen; DiCuccio, Michael; Dondoshansky, Ilya; Federhen, Scott; Feolo, Michael; Geer, Lewis Y.; Gorelenkov, Viatcheslav; Hoeppner, Marilu; Johnson, Mark; Kelly, Christopher; Khotomlianski, Viatcheslav; Kimchi, Avi; Kimelman, Michael; Kitts, Paul; Krasnov, Sergey; Kuznetsov, Anatoliy; Landsman, David; Lipman, David J.; Lu, Zhiyong; Madden, Thomas L.; Madej, Tom; Maglott, Donna R.; Marchler-Bauer, Aron; Karsch-Mizrachi, Ilene; Murphy, Terence; Ostell, James; O'Sullivan, Christopher; Panchenko, Anna; Phan, Lon; Pruitt, Don Preussm Kim D.; Rubinstein, Wendy; Sayers, Eric W.; Schneider, Valerie; Schuler, Gregory D.; Sequeira, Edwin; Sherry, Stephen T.; Shumway, Martin; Sirotkin, Karl; Siyan, Karanjit; Slotta, Douglas; Soboleva, Alexandra; Soussov, Vladimir; Starchenko, Grigory; Tatusova, Tatiana A.; Trawick, Bart W.; Vakatov, Denis; Wang, Yanli; Ward, Minghong; John Wilbur, W.; Yaschenko, Eugene; Zbicz, Kerry

    2014-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI, http://www.ncbi.nlm.nih.gov) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, PubReader, Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Primer-BLAST, COBALT, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, the Genetic Testing Registry, Genome and related tools, the Map Viewer, Trace Archive, Sequence Read Archive, BioProject, BioSample, ClinVar, MedGen, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Probe, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All these resources can be accessed through the NCBI home page. PMID:24259429

  10. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Sayers, Eric W.; Barrett, Tanya; Benson, Dennis A.; Bryant, Stephen H.; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M.; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Feolo, Michael; Geer, Lewis Y.; Helmberg, Wolfgang; Kapustin, Yuri; Landsman, David; Lipman, David J.; Madden, Thomas L.; Maglott, Donna R.; Miller, Vadim; Mizrachi, Ilene; Ostell, James; Pruitt, Kim D.; Schuler, Gregory D.; Sequeira, Edwin; Sherry, Stephen T.; Shumway, Martin; Sirotkin, Karl; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A.; Wagner, Lukas; Yaschenko, Eugene; Ye, Jian

    2009-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the web applications is custom implementation of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:18940862

  11. Database resources of the National Center for Biotechnology Information

    PubMed Central

    2016-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (PubMed Central (PMC), Bookshelf and PubReader), health (ClinVar, dbGaP, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen), genomes (BioProject, Assembly, Genome, BioSample, dbSNP, dbVar, Epigenomics, the Map Viewer, Nucleotide, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser and the Trace Archive), genes (Gene, Gene Expression Omnibus (GEO), HomoloGene, PopSet and UniGene), proteins (Protein, the Conserved Domain Database (CDD), COBALT, Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB) and Protein Clusters) and chemicals (Biosystems and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for most of these databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:26615191

  12. Database resources of the National Center for Biotechnology Information.

    PubMed

    2016-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank(®) nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (PubMed Central (PMC), Bookshelf and PubReader), health (ClinVar, dbGaP, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen), genomes (BioProject, Assembly, Genome, BioSample, dbSNP, dbVar, Epigenomics, the Map Viewer, Nucleotide, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser and the Trace Archive), genes (Gene, Gene Expression Omnibus (GEO), HomoloGene, PopSet and UniGene), proteins (Protein, the Conserved Domain Database (CDD), COBALT, Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB) and Protein Clusters) and chemicals (Biosystems and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for most of these databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:26615191

  13. Database resources of the National Center for Biotechnology Information.

    PubMed

    2013-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI, http://www.ncbi.nlm.nih.gov) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, the Genetic Testing Registry, Genome and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, BioProject, BioSample, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Probe, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page. PMID:23193264

  14. Database resources of the National Center for Biotechnology.

    PubMed

    Wheeler, David L; Church, Deanna M; Federhen, Scott; Lash, Alex E; Madden, Thomas L; Pontius, Joan U; Schuler, Gregory D; Schriml, Lynn M; Sequeira, Edwin; Tatusova, Tatiana A; Wagner, Lukas

    2003-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, PubMed, PubMed Central (PMC), LocusLink, the NCBITaxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR (e-PCR), Open Reading Frame (ORF) Finder, References Sequence (RefSeq), UniGene, HomoloGene, ProtEST, Database of Single Nucleotide Polymorphisms (dbSNP), Human/Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker (MM), Evidence Viewer (EV), Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. PMID:12519941

  15. Database resources of the National Center for Biotechnology Information.

    PubMed

    Wheeler, David L; Barrett, Tanya; Benson, Dennis A; Bryant, Stephen H; Canese, Kathi; Church, Deanna M; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Helmberg, Wolfgang; Kenton, David L; Khovayko, Oleg; Lipman, David J; Madden, Thomas L; Maglott, Donna R; Ostell, James; Pontius, Joan U; Pruitt, Kim D; Schuler, Gregory D; Schriml, Lynn M; Sequeira, Edwin; Sherry, Steven T; Sirotkin, Karl; Starchenko, Grigory; Suzek, Tugba O; Tatusov, Roman; Tatusova, Tatiana A; Wagner, Lukas; Yaschenko, Eugene

    2005-01-01

    In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data retrieval systems and computational resources for the analysis of data in GenBank and other biological data made available through NCBI's website. NCBI resources include Entrez, Entrez Programming Utilities, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of the resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov. PMID:15608222

  16. Database resources of the National Center for Biotechnology Information.

    PubMed

    Sayers, Eric W; Barrett, Tanya; Benson, Dennis A; Bolton, Evan; Bryant, Stephen H; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M; Dicuccio, Michael; Federhen, Scott; Feolo, Michael; Fingerman, Ian M; Geer, Lewis Y; Helmberg, Wolfgang; Kapustin, Yuri; Krasnov, Sergey; Landsman, David; Lipman, David J; Lu, Zhiyong; Madden, Thomas L; Madej, Tom; Maglott, Donna R; Marchler-Bauer, Aron; Miller, Vadim; Karsch-Mizrachi, Ilene; Ostell, James; Panchenko, Anna; Phan, Lon; Pruitt, Kim D; Schuler, Gregory D; Sequeira, Edwin; Sherry, Stephen T; Shumway, Martin; Sirotkin, Karl; Slotta, Douglas; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A; Wagner, Lukas; Wang, Yanli; Wilbur, W John; Yaschenko, Eugene; Ye, Jian

    2012-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Website. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Genome and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, BioProject, BioSample, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Probe, Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), Biosystems, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:22140104

  17. Database resources of the National Center for Biotechnology Information.

    PubMed

    Sayers, Eric W; Barrett, Tanya; Benson, Dennis A; Bolton, Evan; Bryant, Stephen H; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M; Dicuccio, Michael; Federhen, Scott; Feolo, Michael; Geer, Lewis Y; Helmberg, Wolfgang; Kapustin, Yuri; Landsman, David; Lipman, David J; Lu, Zhiyong; Madden, Thomas L; Madej, Tom; Maglott, Donna R; Marchler-Bauer, Aron; Miller, Vadim; Mizrachi, Ilene; Ostell, James; Panchenko, Anna; Pruitt, Kim D; Schuler, Gregory D; Sequeira, Edwin; Sherry, Stephen T; Shumway, Martin; Sirotkin, Karl; Slotta, Douglas; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A; Wagner, Lukas; Wang, Yanli; John Wilbur, W; Yaschenko, Eugene; Ye, Jian

    2010-01-01

    In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, Reference Sequence, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Peptidome, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:19910364

  18. Database resources of the National Center for Biotechnology Information.

    PubMed

    Sayers, Eric W; Barrett, Tanya; Benson, Dennis A; Bryant, Stephen H; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Feolo, Michael; Geer, Lewis Y; Helmberg, Wolfgang; Kapustin, Yuri; Landsman, David; Lipman, David J; Madden, Thomas L; Maglott, Donna R; Miller, Vadim; Mizrachi, Ilene; Ostell, James; Pruitt, Kim D; Schuler, Gregory D; Sequeira, Edwin; Sherry, Stephen T; Shumway, Martin; Sirotkin, Karl; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A; Wagner, Lukas; Yaschenko, Eugene; Ye, Jian

    2009-01-01

    In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the web applications is custom implementation of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:18940862

  19. Database resources of the National Center for Biotechnology Information.

    PubMed

    Wheeler, David L; Barrett, Tanya; Benson, Dennis A; Bryant, Stephen H; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Geer, Lewis Y; Helmberg, Wolfgang; Kapustin, Yuri; Kenton, David L; Khovayko, Oleg; Lipman, David J; Madden, Thomas L; Maglott, Donna R; Ostell, James; Pruitt, Kim D; Schuler, Gregory D; Schriml, Lynn M; Sequeira, Edwin; Sherry, Stephen T; Sirotkin, Karl; Souvorov, Alexandre; Starchenko, Grigory; Suzek, Tugba O; Tatusov, Roman; Tatusova, Tatiana A; Wagner, Lukas; Yaschenko, Eugene

    2006-01-01

    In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Retroviral Genotyping Tools, HIV-1, Human Protein Interaction Database, SAGEmap, Gene Expression Omnibus, Entrez Probe, GENSAT, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. PMID:16381840

  20. Database resources of the National Center for Biotechnology Information.

    PubMed

    Sayers, Eric W; Barrett, Tanya; Benson, Dennis A; Bolton, Evan; Bryant, Stephen H; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M; DiCuccio, Michael; Federhen, Scott; Feolo, Michael; Fingerman, Ian M; Geer, Lewis Y; Helmberg, Wolfgang; Kapustin, Yuri; Landsman, David; Lipman, David J; Lu, Zhiyong; Madden, Thomas L; Madej, Tom; Maglott, Donna R; Marchler-Bauer, Aron; Miller, Vadim; Mizrachi, Ilene; Ostell, James; Panchenko, Anna; Phan, Lon; Pruitt, Kim D; Schuler, Gregory D; Sequeira, Edwin; Sherry, Stephen T; Shumway, Martin; Sirotkin, Karl; Slotta, Douglas; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A; Wagner, Lukas; Wang, Yanli; Wilbur, W John; Yaschenko, Eugene; Ye, Jian

    2011-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Electronic PCR, OrfFinder, Splign, ProSplign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), IBIS, Biosystems, Peptidome, OMSSA, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:21097890

  1. Database resources of the National Center for Biotechnology Information.

    PubMed

    2015-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank(®) nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (Bookshelf, PubMed Central (PMC) and PubReader); medical genetics (ClinVar, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen); genes and genomics (BioProject, BioSample, dbSNP, dbVar, Epigenomics, Gene, Gene Expression Omnibus (GEO), Genome, HomoloGene, the Map Viewer, Nucleotide, PopSet, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser, Trace Archive and UniGene); and proteins and chemicals (Biosystems, COBALT, the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB), Protein Clusters, Protein and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for many of these databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov. PMID:25398906

  2. Database resources of the National Center for Biotechnology Information.

    PubMed

    2014-01-01

    In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI, http://www.ncbi.nlm.nih.gov) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, PubReader, Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Primer-BLAST, COBALT, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, the Genetic Testing Registry, Genome and related tools, the Map Viewer, Trace Archive, Sequence Read Archive, BioProject, BioSample, ClinVar, MedGen, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Probe, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All these resources can be accessed through the NCBI home page. PMID:24259429

  3. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Wheeler, David L.; Barrett, Tanya; Benson, Dennis A.; Bryant, Stephen H.; Canese, Kathi; Church, Deanna M.; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Helmberg, Wolfgang; Kenton, David L.; Khovayko, Oleg; Lipman, David J.; Madden, Thomas L.; Maglott, Donna R.; Ostell, James; Pontius, Joan U.; Pruitt, Kim D.; Schuler, Gregory D.; Schriml, Lynn M.; Sequeira, Edwin; Sherry, Steven T.; Sirotkin, Karl; Starchenko, Grigory; Suzek, Tugba O.; Tatusov, Roman; Tatusova, Tatiana A.; Wagner, Lukas; Yaschenko, Eugene

    2005-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data retrieval systems and computational resources for the analysis of data in GenBank and other biological data made available through NCBI's website. NCBI resources include Entrez, Entrez Programming Utilities, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of the resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov. PMID:15608222

  4. Database resources of the National Center for Biotechnology

    PubMed Central

    Wheeler, David L.; Church, Deanna M.; Federhen, Scott; Lash, Alex E.; Madden, Thomas L.; Pontius, Joan U.; Schuler, Gregory D.; Schriml, Lynn M.; Sequeira, Edwin; Tatusova, Tatiana A.; Wagner, Lukas

    2003-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, PubMed, PubMed Central (PMC), LocusLink, the NCBITaxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR (e-PCR), Open Reading Frame (ORF) Finder, References Sequence (RefSeq), UniGene, HomoloGene, ProtEST, Database of Single Nucleotide Polymorphisms (dbSNP), Human/Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker (MM), Evidence Viewer (EV), Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. PMID:12519941

  5. The Homeodomain Resource: a comprehensive collection of sequence, structure, interaction, genomic and functional information on the homeodomain protein family

    PubMed Central

    Moreland, R. Travis; Ryan, Joseph F.; Pan, Christopher; Baxevanis, Andreas D.

    2009-01-01

    The Homeodomain Resource is a curated collection of sequence, structure, interaction, genomic and functional information on the homeodomain family. The current version builds upon previous versions by the addition of new, complete sets of homeodomain sequences from fully sequenced genomes, the expansion of existing curated homeodomain information and the improvement of data accessibility through better search tools and more complete data integration. This release contains 1534 full-length homeodomain-containing sequences, 93 experimentally derived homeodomain structures, 101 homeodomain protein–protein interactions, 107 homeodomain DNA-binding sites and 206 homeodomain proteins implicated in human genetic disorders. Database URL: The Homeodomain Resource is freely available and can be accessed at http://research.nhgri.nih.gov/homeodomain/ PMID:20157477

  6. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine.

    PubMed

    Flannery, Brenna M; Silverman, Jill L; Bruun, Donald A; Puhger, Kyle R; McCoy, Mark R; Hammock, Bruce D; Crawley, Jacqueline N; Lein, Pamela J

    2015-01-01

    Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison that is thought to trigger seizures by inhibiting the function of the type A gamma-aminobutyric acid receptor (GABAAR). Acute intoxication with TETS can cause vomiting, convulsions, status epilepticus (SE) and even death. Clinical case reports indicate that individuals who survive poisoning may exhibit long-term neuropsychological issues and cognitive deficits. Therefore, the objective of this research was to determine whether a recently described mouse model of acute TETS intoxication exhibits persistent behavioral deficits. Young adult male NIH Swiss mice received a seizure-inducing dose of TETS (0.15mg/kg, ip) and then were rescued from lethality by administration of diazepam (5mg/kg, ip) approximately 20min post-TETS-exposure. TETS-intoxicated mice typically exhibited 2 clonic seizures prior to administration of diazepam with no subsequent seizures post-diazepam injection as assessed using behavioral criteria. Seizures lasted an average of 72s. Locomotor activity, anxiety-like and depression-relevant behaviors and cognition were assessed at 1week, 1month and 2months post-TETS exposure using open field, elevated-plus maze, light↔dark transitions, tail suspension, forced swim and novel object recognition tasks. Interestingly, preliminary validation tests indicated that NIH Swiss mice do not respond to the shock in fear conditioning tasks. Subsequent evaluation of hot plate and tail flick nociception tasks revealed that this strain exhibits significantly decreased pain sensitivity relative to age- and sex-matched C57BL/6J mice, which displayed normal contextual fear conditioning. NIH Swiss mice acutely intoxicated with TETS exhibited no significant anxiety-related, depression-relevant, learning or memory deficits relative to vehicle controls at any of the time points assessed with the exception of significantly increased locomotor activity at 2months post-TETS intoxication. The general absence

  7. The NIH Toolbox Pattern Comparison Processing Speed Test: Normative Data

    PubMed Central

    Carlozzi, Noelle E.; Beaumont, Jennifer L.; Tulsky, David S.; Gershon, Richard C.

    2015-01-01

    The NIH Toolbox Pattern Comparison Processing Speed Test was developed to assess processing speed. While initial validation work provides preliminary support for this test in both children and adults, more work is needed to ensure dependability and generalizability. Thus, this replication study examines descriptive data (including age effects), test–retest reliability, and construct validity in n = 4,859 participants ages 3–85 years (matched to 2010 census data). Although the Pattern Comparison was not appropriate for all 3 and 4 years old, by ages 5 and 6, more meaningful scores were apparent. There was evidence for convergent and discriminant validity. There was also a moderate practice effect (i.e., increase of 5.5 points) over a 1-week time frame. Pattern Comparison exhibits a number of strengths: it is appropriate for use across the lifespan (ages 5–85), it is short and easy to administer, and there is support for construct validity. PMID:26025230

  8. The NIH Toolbox Pattern Comparison Processing Speed Test: Normative Data.

    PubMed

    Carlozzi, Noelle E; Beaumont, Jennifer L; Tulsky, David S; Gershon, Richard C

    2015-08-01

    The NIH Toolbox Pattern Comparison Processing Speed Test was developed to assess processing speed. While initial validation work provides preliminary support for this test in both children and adults, more work is needed to ensure dependability and generalizability. Thus, this replication study examines descriptive data (including age effects), test-retest reliability, and construct validity in n = 4,859 participants ages 3-85 years (matched to 2010 census data). Although the Pattern Comparison was not appropriate for all 3 and 4 years old, by ages 5 and 6, more meaningful scores were apparent. There was evidence for convergent and discriminant validity. There was also a moderate practice effect (i.e., increase of 5.5 points) over a 1-week time frame. Pattern Comparison exhibits a number of strengths: it is appropriate for use across the lifespan (ages 5-85), it is short and easy to administer, and there is support for construct validity. PMID:26025230

  9. Tightening Conflict-of-Interest Policies: The Impact of 2005 Ethics Rules at the NIH

    PubMed Central

    Zinner, Darren E.; DesRoches, Catherine M.; Bristol, Steffanie J.; Clarridge, Brian; Campbell, Eric G.

    2013-01-01

    Purpose To determine both the intended and unintended effects of the National Institutes of Health (NIH) 2005 ethics rules by examining changes in publishing rates and the frequency of external relationships among NIH scientists. Method After identifying eligible intramural scientists and administrators from institute’s web pages and central directories, a mailed survey was administered to 900 NIH research faculty between October 2008 and January 2009 (response rate 70.1%).A Results Eighty percent of respondents believed the NIH ethics rules were too restrictive. While nearly half (45%) of respondents believed the rules positively impacted the public’s trust in the NIH, over three-quarters (77%) believed the rules hindered the NIH’s ability to complete its mission. Implementation of the ethics rules significantly decreased self-reported GIRs among NIH faculty (from 51.8% to 33.2%, P<.01), including significant drops in consulting (33.1% to 7.8%, P<.01) and scientific advisory board membership (31.5% to 16.0%, P<.01). The policy had limited impact on NIH faculty participation in non-industrial professional service roles and had no detectable change in publishing behavior (5.29 articles per researcher per year from 2002–2005 vs. 5.26 from 2005–2008, P = .88). Conclusions The NIH ethics rules accomplished much of what they were intended to do, limiting relationships with industry while maintaining NIH researchers’ association with external scientific and professional organizations. However, the rules negatively affected personnel morale and the perceived progress of research. PMID:20852402

  10. Off the Roadmap? Family Medicine’s Grant Funding and Committee Representation at NIH

    PubMed Central

    Lucan, Sean C.; Phillips, Robert L.; Bazemore, Andrew W.

    2008-01-01

    PURPOSE Family medicine is challenged to develop its own research infrastructure and to inform and contribute to a national translational-research agenda. Toward these ends, understanding family medicine’s engagement with the National Institutes of Health (NIH) is important. METHODS We descriptively analyzed NIH grants to family medicine from 2002 through 2006 and the current NIH advisory committee memberships. RESULTS Grants (and dollars) awarded to departments of family medicine increased from 89 ($25.6 million) in 2002, to 154 ($44.6 million) in 2006. These values represented only 0.20% (0.15% for dollars) and 0.33% (0.22% for dollars), respectively, of total NIH awards. Nearly 75% of family medicine grants came from just 6 of NIH’s grant-funding 24 institutes and centers. Although having disproportionately fewer grant continuations (62% vs 72%) and R awards (68% vs 74%)—particularly R01 awards (53% vs 84%)—relative to NIH grantees overall, family medicine earned proportionately more new (28% vs 21%) and K awards (25% vs 9%) and had more physician principal investigators (52% vs 15%). Ten of the nation’s 132 departments of family medicine (7.6%) earned almost 50% of all family medicine awards. Representatives from family medicine were on 6.4% of NIH advisory committees (0.38% of all members); family physicians were on 2.7% (0.16% of members). CONCLUSIONS Departments of family medicine, and family physicians in particular, receive a miniscule proportion of NIH grant funding and have correspondingly minimal representation on standing NIH advisory committees. Family medicine’s engagement at the NIH remains near well-documented historic lows, undermining family medicine’s potential for translating medical knowledge into community practice, and advancing knowledge to improve health care and health for the US population as a whole. PMID:19001306

  11. Effect of Handling, Storage and Cycling on Ni-H2 Cells: Second Plateau Phenomenon

    NASA Technical Reports Server (NTRS)

    Vaidyanathan, Hari; Rao, Gopalakrishna

    2001-01-01

    Proper handling of Ni-H2 cells/batteries in storage, during I&T, and at launch site is very important to preserve the useful energy and to extend the mission life. Cell reversal test is not a prudent test to verify or quantify the nickel pre-charge in Ni-H2 cells/batteries. The second plateau is due to the formation of Ni(+3) that is electrochemically inactive. Gas analysis of the cell, and chemical analysis of the positive plate are confirmatory tests to determine the nature of pre-charge in Ni-H2 cells.

  12. GeneEd—A Genetics Educational Resource | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 9-12 to learn genetics. Topics include cell biology, DNA, genes, chromosomes, and much more. GeneEd also provides lesson plans, genetic educational materials, printable activity sheets, and other ...

  13. Recommended Resources about Eleanor Roosevelt.

    ERIC Educational Resources Information Center

    Social Education, 1984

    1984-01-01

    Books, films, and additional resources available from the National Women's History Resource Service are included in this annotated listing of resource materials which can be used to teach about Eleanor Roosevelt in elementary and secondary social studies classrooms. (RM)

  14. The origin and implementation of the Broadening Experiences in Scientific Training programs: an NIH common fund initiative.

    PubMed

    Meyers, Frederick J; Mathur, Ambika; Fuhrmann, Cynthia N; O'Brien, Theresa C; Wefes, Inge; Labosky, Patricia A; Duncan, D'Anne S; August, Avery; Feig, Andrew; Gould, Kathleen L; Friedlander, Michael J; Schaffer, Chris B; Van Wart, Audra; Chalkley, Roger

    2016-02-01

    Recent national reports and commentaries on the current status and needs of the U.S. biomedical research workforce have highlighted the limited career development opportunities for predoctoral and postdoctoral trainees in academia, yet little attention is paid to preparation for career pathways outside of the traditional faculty path. Recognizing this issue, in 2013, the U.S. National Institutes of Health (NIH) Common Fund issued a request for application titled "NIH Director's Biomedical Research Workforce Innovation Award: Broadening Experiences in Scientific Training (BEST)." These 5-yr 1-time grants, awarded to 17 single or partnering institutions, were designed to develop sustainable approaches to broaden graduate and postgraduate training, aimed at creating training programs that reflect the range of career options that trainees may ultimately pursue. These institutions have formed a consortium in order to work together to develop, evaluate, share, and disseminate best practices and challenges. This is a first report on the early experiences of the consortium and the scope of participating BEST programs. In this report, we describe the state of the U.S. biomedical workforce and development of the BEST award, variations of programmatic approaches to assist with program design without BEST funding, and novel approaches to engage faculty in career development programs. To test the effectiveness of these BEST programs, external evaluators will assess their outcomes not only over the 5 yr grant period but also for an additional 10 yr beyond award completion. PMID:26432783

  15. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.

    PubMed

    Akkina, Ramesh; Allam, Atef; Balazs, Alejandro B; Blankson, Joel N; Burnett, John C; Casares, Sofia; Garcia, J Victor; Hasenkrug, Kim J; Kashanchi, Fatah; Kitchen, Scott G; Klein, Florian; Kumar, Priti; Luster, Andrew D; Poluektova, Larisa Y; Rao, Mangala; Sanders-Beer, Brigitte E; Shultz, Leonard D; Zack, Jerome A

    2016-02-01

    The number of humanized mouse models for the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and other infectious diseases has expanded rapidly over the past 8 years. Highly immunodeficient mouse strains, such as NOD/SCID/gamma chain(null) (NSG, NOG), support better human hematopoietic cell engraftment. Another improvement is the derivation of highly immunodeficient mice, transgenic with human leukocyte antigens (HLAs) and cytokines that supported development of HLA-restricted human T cells and heightened human myeloid cell engraftment. Humanized mice are also used to study the HIV reservoir using new imaging techniques. Despite these advances, there are still limitations in HIV immune responses and deficits in lymphoid structures in these models in addition to xenogeneic graft-versus-host responses. To understand and disseminate the improvements and limitations of humanized mouse models to the scientific community, the NIH sponsored and convened a meeting on April 15, 2015 to discuss the state of knowledge concerning these questions and best practices for selecting a humanized mouse model for a particular scientific investigation. This report summarizes the findings of the NIH meeting. PMID:26670361

  16. Nanofiber Alignment Regulates NIH3T3 Cell Orientation and Cytoskeletal Gene Expression on Electrospun PCL+Gelatin Nanofibers

    PubMed Central

    Fee, Timothy; Surianarayanan, Swetha; Downs, Crawford; Zhou, Yong; Berry, Joel

    2016-01-01

    To examine the influence of substrate topology on the behavior of fibroblasts, tissue engineering scaffolds were electrospun from polycaprolactone (PCL) and a blend of PCL and gelatin (PCL+Gel) to produce matrices with both random and aligned nanofibrous orientations. The addition of gelatin to the scaffold was shown to increase the hydrophilicity of the PCL matrix and to increase the proliferation of NIH3T3 cells compared to scaffolds of PCL alone. The orientation of nanofibers within the matrix did not have an effect on the proliferation of adherent cells, but cells on aligned substrates were shown to elongate and align parallel to the direction of substrate fiber alignment. A microarray of cyotoskeleton regulators was probed to examine differences in gene expression between cells grown on an aligned and randomly oriented substrates. It was found that transcriptional expression of eight genes was statistically different between the two conditions, with all of them being upregulated in the aligned condition. The proteins encoded by these genes are linked to production and polymerization of actin microfilaments, as well as focal adhesion assembly. Taken together, the data indicates NIH3T3 fibroblasts on aligned substrates align themselves parallel with their substrate and increase production of actin and focal adhesion related genes. PMID:27196306

  17. Nanofiber Alignment Regulates NIH3T3 Cell Orientation and Cytoskeletal Gene Expression on Electrospun PCL+Gelatin Nanofibers.

    PubMed

    Fee, Timothy; Surianarayanan, Swetha; Downs, Crawford; Zhou, Yong; Berry, Joel

    2016-01-01

    To examine the influence of substrate topology on the behavior of fibroblasts, tissue engineering scaffolds were electrospun from polycaprolactone (PCL) and a blend of PCL and gelatin (PCL+Gel) to produce matrices with both random and aligned nanofibrous orientations. The addition of gelatin to the scaffold was shown to increase the hydrophilicity of the PCL matrix and to increase the proliferation of NIH3T3 cells compared to scaffolds of PCL alone. The orientation of nanofibers within the matrix did not have an effect on the proliferation of adherent cells, but cells on aligned substrates were shown to elongate and align parallel to the direction of substrate fiber alignment. A microarray of cyotoskeleton regulators was probed to examine differences in gene expression between cells grown on an aligned and randomly oriented substrates. It was found that transcriptional expression of eight genes was statistically different between the two conditions, with all of them being upregulated in the aligned condition. The proteins encoded by these genes are linked to production and polymerization of actin microfilaments, as well as focal adhesion assembly. Taken together, the data indicates NIH3T3 fibroblasts on aligned substrates align themselves parallel with their substrate and increase production of actin and focal adhesion related genes. PMID:27196306

  18. NIH study uncovers new mechanism of action for class of chemotherapy drugs

    Cancer.gov

    NIH researchers have discovered a significant new mechanism of action for a class of chemotherapy drugs known as poly (ADP-ribose) polymerase inhibitors, or PARP inhibitors. They have also identified differences in the toxic capabilities of three drugs in

  19. LABORATORY MEASUREMENTS OF NiH BY FOURIER TRANSFORM DISPERSED FLUORESCENCE

    SciTech Connect

    Vallon, Raphael; Richard, Cyril; Crozet, Patrick; Wannous, Ghassan; Ross, Amanda

    2009-05-01

    Red and orange bands of laser-induced fluorescence in NiH have been recorded on a Fourier transform interferometer at Doppler resolution. The spectra show strong transitions to low-lying vibronic states which are not thermally populated in a laboratory source, and therefore do not appear in laser excitation spectra, but which would be expected to contribute significantly to any stellar spectrum. The strongest bands belong to the G[{omega}' 5/2]-X {sub 2} {sup 2}{delta}{sub 3/2}, I[{omega}' 3/2]-X {sub 2}, and {sup 2}{delta}{sub 3/2} I[{omega}' 3/2]-W {sub 1} {sup 2}{pi}{sub 3/2} systems. Measurements are reported for {sup 58}NiH, {sup 60}NiH, and {sup 62}NiH.

  20. Videos from the National Eye Institute: Eye Diseases | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: Vision Videos from the National Eye Institute: Eye Diseases Past ... the early detection of eye disease. Share these videos with friends, family and colleagues. www.nei.nih. ...

  1. Go4Life:Success Stories | NIH MedlinePlus the Magazine

    MedlinePlus

    ... routine and a low-fat diet. NIHSenior Health Videos Exercising with the NIH Directors The leadership of ... nihseniorhealth.gov/videolist.html#exercise . Click to play video Richard J. Hodes, M.D., Director, National Institute ...

  2. Exercise Is Key to Healthy Aging | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn JavaScript on. NIH Research Exercise Is Key to Healthy Aging Past Issues / Winter ... to exercise regularly—at any age! Why is exercise so important? Exercise is perhaps the best demonstrated ...

  3. Diagnosis & Treatment | Coronary Artery Disease | NIH MedlinePlus the Magazine

    MedlinePlus

    ... blockage is. Treatment Latest NIH Research Recent gene-mapping research has found the largest set of genes ... the arteries and improves blood flow to the brain, helping prevent a stroke. Fall 2010 Issue: Volume ...

  4. Methods and management: NIH administrators, federal oversight, and the Framingham Heart Study.

    PubMed

    Patel, Sejal S

    2012-01-01

    This article explores the 1965 controversy over the Framingham Heart Study in the midst of growing oversight into the management of science at the National Institutes of Health (NIH). It describes how, beginning in the early 1960s, federal overseers demanded that NIH administrators adopt particular management styles in administering programs and how these growing pressures led administrators to favor investigative pursuits that allowed for easy prospective accounting of program payoffs, especially those based on experimental methods designed to examine discrete interventions or outcomes of interest. In light of this changing managerial culture within the NIH, the Framingham study and other population laboratories-with their bases in observation and in open-ended study designs-became harder for NIH administrators to justify and defend. PMID:22643985

  5. Globetrotting to a Good Night's Sleep | NIH MedlinePlus the Magazine

    MedlinePlus

    ... is one of the most common and troubling sleep disorders. At least 1 in 10 older adults, and ... have sleep apnea. To Find Out More MedlinePlus Sleep Disorders www.nlm.nih.gov/medlineplus/sleepdisorders.html NHLBI ...

  6. Suicide in the Military: Army-NIH Funded Study Points to Risk and Protective Factors

    MedlinePlus

    ... Office 301-443-4536 NIMHpress@nih.gov More Science News about Basic Research Military Service Members Suicide ... the Field News from the Field NIMH-Funded Science on EurekAlert Lack of Sleep Increases a Child's ...

  7. NIGMS Researcher Explores Skin Cities | NIH MedlinePlus the Magazine

    MedlinePlus

    ... coming to NIH to tackle bacterial genomics. Beneficial Bacteria Bacteria aren't all bad. Many are harmless, and ... protect us by taking up space where harmful bacteria would otherwise live. It might sound unhealthy or ...

  8. 76 FR 62816 - Office of Biotechnology Activities; Recombinant DNA Research: Action Under the NIH Guidelines for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... experts from NIH, CDC, and academia. These proposed changes were published in the Federal Register (76 FR...) classification for several common attenuated strains of bacteria and viruses that are frequently used...

  9. What Research is being done? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: Stroke Rehabilitation What Research is Being Done? Past Issues / Spring ... of Contents To Find Out More MedlinePlus: Stroke Rehabilitation www.nlm.nih.gov/medlineplus/strokerehabilitation.html National ...

  10. Cancer Survivor Eric Dishman Is On a Precision Medicine Mission | NIH MedlinePlus the Magazine

    MedlinePlus

    ... devices can encourage healthy behaviors Lay the scientific foundation for precision medicine for many diseases Find Out More National Center for Advancing Translational Sciences (NCATS) : https://ncats.nih.gov MedlinePlus: (search for ...

  11. HealthLines - Plan to Get Your Flu Shot | NIH MedlinePlus the Magazine

    MedlinePlus

    ... supplements with an anti-inflammatory drug and a placebo (or dummy pill). Researchers say people who took ... of the treatments was significantly better than the placebo. Two components of NIH funded the study, which ...

  12. ASD: What Are Autism Spectrum Disorders? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... the parents/caregivers, teachers, school psychologists, and other child development specialists work together to design an Individualized Education ... search box. Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) booklets: www.nichd.nih.gov/publications/pubs/ ...

  13. Healthy Aging: What's On Your Plate? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn JavaScript on. Feature: Healthy Aging What's On Your Plate? Past Issues / Winter 2015 ... On Your Plate? Smart Food Choices for Healthy Aging www.nia.nih.gov/health/publication/whats-your- ...

  14. NIH Scientists Map Genetic Changes That Drive Tumors in a Common Pediatric Soft-Tissue Cancer

    MedlinePlus

    ... Press Releases NCI Press Release NIH scientists map genetic changes that drive tumors in a common pediatric ... Office 301-496-6641 Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric ...

  15. More Young Adults at Risk for High Blood Pressure | NIH MedlinePlus the Magazine

    MedlinePlus

    ... young adults have high blood pressure. NIH-funded analysis indicates higher risk for young adults than previously ... 12 ounces of beer or five ounces of wine.) Finally, quit smoking. Among other things, smoking damages ...

  16. What Do We Know About Preventing Alzheimer's? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... read Participating in Alzheimer's Research: For Yourself and Future Generations http://www.nia.nih.gov/alzheimers/publication/participating-alzheimers-research/introduction . You can also contact the NIA Alzheimer's Disease Education and Referral (ADEAR) Center at 1-800- ...

  17. Risk Factors, Treatment and Research | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Feature: Fighting Gum Disease Risk Factors, Treatment and Research Past Issues / Fall 2010 Table of Contents Risk ... out whether it offers this service. Latest NIH Research Researchers supported by the National Institute of Dental ...

  18. Developing Safe and Effective Medicines for Children | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD). She is also helping to make drugs ... Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is the lead NIH agency helping to ...

  19. 75 FR 63489 - Proposed Collection; Comment Request; NIH Office of Intramural Training & Education Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ..., scientific discipline interests, educational history, standardized examination scores, reference information, resume ] components, employment history, employment interests, dissertation research details, letters of... educational level individuals into the National Institutes of Health Intramural Research Program (NIH-IRP)...

  20. Paralyzed Patients Regain Voluntary Movement | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: Spinal Cord Stimulation Paralyzed Patients Regain Voluntary Movement Past Issues / ... Groundbreaking NIH study spurs hope for those with spinal cord injury Flex a muscle, any muscle? Certainly, it's ...

  1. Methods and Management: NIH Administrators, Federal Oversight, and the Framingham Heart Study

    PubMed Central

    Patel, Sejal S.

    2012-01-01

    Summary This article explores the 1965 controversy over the Framingham Heart Study in the midst of growing oversight into the management of science at the National Institutes of Health (NIH). It describes how, beginning in the early 1960s, federal overseers demanded that NIH administrators adopt particular management styles in administering programs and how these growing pressures led administrators to favor investigative pursuits that allowed for easy prospective accounting of program payoffs, especially those based on experimental methods designed to examine discrete interventions or outcomes of interest. In light of this changing managerial culture within the NIH, the Framingham study and other population laboratories—with their bases in observation and in open-ended study designs—became harder for NIH administrators to justify and defend. PMID:22643985

  2. NIH Researchers Identify New Gene Mutation Associated with ALS and Dementia

    MedlinePlus

    ... NIH researchers identify new gene mutation associated with ALS and dementia April 7, 2014 A rare mutation ... cell, has been linked with development of familial amyotrophic lateral sclerosis (ALS). This finding, from a research team led ...

  3. To Your Health: NLM update transcript - NIH MedlinePlus magazine Spring 2016

    MedlinePlus

    ... The new edition of NIH MedlinePlus magazine covers fibromyalgia, health disparities, as well as women and heart ... MedlinePlus magazine also provides a special section about fibromyalgia, a chronic pain condition that impacts five million ...

  4. The Future of Personalized Medicine | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. The Future of Personalized Medicine, From NIH Director Dr. Francis S. ... your physician to be sure you are taking advantage of all possible methods for surveillance and early ...

  5. Dr. Lindberg's Legacy : Charting A New Course | NIH MedlinePlus the Magazine

    MedlinePlus

    ... B. Lindberg, MD Pioneering Leader for Medicine and Computers Retires as Director of the National Library of ... leaders at NIH and a pioneer in applying computer and communications technology to biomedical research, health care, ...

  6. Five Decades of Discovery: National Institute of General Medical Sciences | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Decades of Discovery: National Institute of General Medical Sciences Past Issues / Summer 2012 Table of Contents It ... anniversary of the National Institute of General Medical Sciences (NIGMS), known to many as NIH's "basic research ...

  7. 78 FR 17935 - Proposed Collection; Comment Request: NIH Office of Intramural Training & Education Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... (NIH) will publish periodic summaries of proposed projects to be submitted to the Office of Management... annual reporting burden is displayed in the following table: Estimated No. Estimated No. of...

  8. Living Well with COPD, Q&A: Grace Anne Koppel | NIH MedlinePlus the Magazine

    MedlinePlus

    ... The NIH's COPD Learn More Breathe Better ® Campaign Network is now in all 50 states and the ... Learn More Breathe Better® program encourages Breathe Better Network members and all those interested in raising COPD ...

  9. Putting A Face On Rare Diseases | NIH MedlinePlus the Magazine

    MedlinePlus

    ... part of this global observance. Since 2010, the slogan for NIH's event has been "Patients & Researchers—Partners for Life." This slogan aligns with NCATS' philosophy that researchers must work ...

  10. Cholesterol Levels: What You Need to Know | NIH MedlinePlus the Magazine

    MedlinePlus

    ... please turn Javascript on. Feature: High Cholesterol Cholesterol Levels: What You Need to Know Past Issues / Summer 2012 Table of Contents Measuring Cholesterol Levels Learn more at MedlinePlus: https://www.nlm.nih. ...

  11. What Do Fats Do in the Body? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... on NIH Research What Do Fats Do in the Body? Past Issues / Spring 2013 Table of Contents ... gov/insidelifescience/ When you have your cholesterol checked, the doctor typically gives you your levels of three ...

  12. Turning Discovery Into Health – Asthma | NIH MedlinePlus the Magazine

    MedlinePlus

    ... untargeted research. NIH not only supports these basic advances but also conducts the clinical and translational research that transforms discoveries into medical practice in four areas: chronic diseases, infectious diseases, personalized medicine and new technologies, and health at all ages. ...

  13. More Young Adults at Risk for High Blood Pressure | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Feature: High Blood Pressure More Young Adults at Risk for High Blood Pressure Past Issues / Fall 2011 ... high blood pressure. NIH-funded analysis indicates higher risk for young adults than previously believed. With more ...

  14. Paralyzed Patients Regain Voluntary Movement | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Groundbreaking NIH study spurs hope for those with spinal cord injury Flex a muscle, any muscle? Certainly, it's second ... little realistic hope of any meaningful recovery from spinal cord injury may benefit from this intervention," says NIBIB Director ...

  15. Approaching Health Disparities from a Population Perspective: The NIH Centers for Population Health and Health Disparities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Addressing health disparities has been a national challenge for decades. The NIH-sponsored Centers for Population Health and Health Disparities (CPHHDs) represent the first federal initiative to support transdisciplinary multilevel research on the determinants of health disparities. Using preliminar...

  16. Healthy Aging: What's On Your Plate? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... 2015 Table of Contents What's On Your Plate? Smart Food Choices for Healthy Aging www.nia.nih. ... on 2,000 calories a day with these smart food choices. Get more nutrition information online with ...

  17. Sex Differences in Application, Success, and Funding Rates for NIH Extramural Programs

    PubMed Central

    Pohlhaus, Jennifer Reineke; Jiang, Hong; Wagner, Robin M.; Schaffer, Walter T.; Pinn, Vivian W.

    2011-01-01

    Purpose The authors provide an analysis of sex differences in National Institutes of Health (NIH) award programs to inform potential initiatives for promoting diversity in the research workforce. Method In 2010, the authors retrieved data for NIH extramural grants in the electronic Research Administration Information for Management, Planning, and Coordination II database, and used statistical analysis to determine any sex differences in securing NIH funding, as well as subsequent success of researchers who had already received independent NIH support. Results Success and funding rates for men and women were not significantly different in most award programs. Furthermore, in programs where participation was lower for women than men, the disparity was primarily related to a lower percentage of women applicants compared to men, rather than decreased success rates or funding rates. However, for subsequent grants, both application and funding rates were generally higher for men than for women. Conclusions Cross-sectional analysis showed that women and men were generally equally successful at all career stages, but longitudinal analysis showed that men with previous experience as NIH grantees had higher application and funding rates than women at similar career points. On average, although women received larger R01 awards than men, men had more R01 awards than women at all points in their careers. Therefore, while greater participation of women in NIH programs is underway, further action will be required to eradicate remaining sex differences. PMID:21512358

  18. [Envelope protein of Jaagsiekte sheep retrovious expressed in NIH3T3 cells promotes cell proliferation].

    PubMed

    DU, Fangyuan; Chen, Dayong; Zhang, Yufei; Sun, Xiaolin; Guo, Wenqing; Liu, Shuying

    2016-09-01

    Objective To explore the influence of the exogenous Jaagsiekte sheep retrovious (exJSRV) envelope protein (Env) on NIH3T3 cell proliferation. Methods A recombinant plasmid pcDNA4/myc-His/exJSRV- env carrying exJSRV- env gene was constructed, and then the correctness of the recombinant plasmid was identified by PCR, restriction enzyme digestion and sequencing. The recombinant plasmid pcDNA4/myc-His/exJSRV- env was transiently transfected into NIH3T3 cells by Lipofectamine(TM) LTX. After the transfection of the recombinant plasmid, the expression of exJSRV- env was detected by reverse transcription PCR and Western blotting. The effect of Env on cell proliferation was investigated by CCK-8 assay and plate colony formation assay. Results The recombinant eukaryotic expression plasmid containing exJSRV- env was successfully constructed as identified by PCR, restriction enzyme identification and sequencing. After the recombinant plasmid was transiently transfected into NIH3T3 cells, reverse transcription PCR and Western blotting showed the expression of exJSRV- env , and Env promoted NIH3T3 cell proliferation significantly. Conclusion JSRV Env was expressed successfully in the NIH3T3 cells and promoted the proliferation of NIH3T3 cells. PMID:27609573

  19. Singly Bonded Monoadduct rather than Methanofullerene: Manipulating the Addition Pattern of Trimetallic Nitride Clusterfullerene through One Endohedral Metal Atom Substitution.

    PubMed

    Wang, Song; Huang, Jing; Gao, Congli; Jin, Fei; Li, Qunxiang; Xie, Suyuan; Yang, Shangfeng

    2016-06-01

    Bingel-Hirsch reactions of trimetallic nitride clusterfullerenes (NCFs) generally yield methanofullerene (cyclopropane) adducts instead of singly bonded derivatives, which have been reported for monometallofullerenes. Herein, we report the synthesis and characterization of the Bingel-Hirsch derivative of a mixed metal nitride clusterfullerene (MMNCF) TiY2 N@Ih -C80 . Surprisingly, in contrast to the reported Bingel-Hirsch cyclopropane adducts of the analogous NCF Y3 N@Ih -C80 , the Bingel-Hirsch derivative of TiY2 N@Ih -C80 is the first singly bonded monoadduct (labeled as TiY2 N@C80 -Mono) to be reported, which was determined unambiguously by single-crystal X-ray crystallography. Besides, the reactivity of TiY2 N@Ih -C80 was found to be significantly improved relative to that of Y3 N@Ih -C80 . Upon substituting one endohedral yttrium (Y) atom of Y3 N@Ih -C80 with titanium (Ti), the Bingel-Hirsch derivative changes from the cyclopropane to the singly bonded monoadduct, revealing that not only the reactivity but also the addition pattern of NCFs can be manipulated simultaneously through one endohedral metal atom substitution. PMID:27115985

  20. Advances in Patient-Reported Outcomes: The NIH PROMIS® Measures

    PubMed Central

    Broderick, Joan E.; DeWitt, Esi Morgan; Rothrock, Nan; Crane, Paul K.; Forrest, Christopher B.

    2013-01-01

    Patient-reported outcomes (PRO) are questionnaire measures of patients’ symptoms, functioning, and health-related quality of life. They are designed to provide important clinical information that generally cannot be captured with objective medical testing. In 2004, the National Institutes of Health launched a research initiative to improve the clinical research enterprise by developing state-of-the-art PROs. The NIH Patient-Reported Outcomes Measurement System (PROMIS) and Assessment Center are the products of that initiative. Adult, pediatric, and parent-proxy item banks have been developed by using contemporary psychometric methods, yielding rapid, accurate measurements. PROMIS currently provides tools for assessing physical, mental, and social health using short-form and computer-adaptive testing methods. The PROMIS tools are being adopted for use in clinical trials and translational research. They are also being introduced in clinical medicine to assess a broad range of disease outcomes. Recent legislative developments in the United States support greater efforts to include patients’ reports of health experience in order to evaluate treatment outcomes, engage in shared decision-making, and prioritize the focus of treatment. PROs have garnered increased attention by the Food and Drug Administration (FDA) for evaluating drugs and medical devices. Recent calls for comparative effectiveness research favor inclusion of PROs. PROs could also potentially improve quality of care and disease outcomes, provide patient-centered assessment for comparative effectiveness research, and enable a common metric for tracking outcomes across providers and medical systems. PMID:25848562

  1. Thermal modeling of a Ni-H2 battery cell

    NASA Technical Reports Server (NTRS)

    Ryu, Si-Ok; Dewitt, K. J.; Keith, T. G.

    1991-01-01

    The nickel-hydrogen secondary battery has many desirable features which make it attractive for satellite power systems. It can provide a significant improvement over the energy density of present spacecraft nickel-cadnium batteries, combined with longer life, tolerance to overcharge and possibility of state-of-charge indication. However, to realize these advantages, accurate thermal modeling of nickel-hydrogen cells is required in order to properly design the battery pack so that it operates within a specified temperature range during the operation. Maintenance of a low operating temperature and a uniform temperature profile within the cell will yield better reliability, improved cycle life and better charge/discharge efficiencies. This research has the objective of developing and testing a thermal model which can be used to characterize battery operation. Primarily, temperature distribution with the heat generation rates as a function of position and time will be evaluated for a Ni-H2 cell in the three operating modes: (1) charge cycle, (2) discharge cycle, and (3) overcharge condition, if applicable. Variables to be examined include charging current, discharge rates, state of charge, pressure and temperature. Once the thermal model has been developed, this resulting model will predict the actual operating temperature and temperature gradient for the specific cell geometry to be used.

  2. Air Force NiH2 IPV storage testing

    SciTech Connect

    Smellie, S.; Hill, C.A.

    1996-02-01

    USAF Phillips Laboratory Nickel Hydrogen IPV storage test, performed at the Naval Surface Warfare Center (NSWC) at Crane Indiana, is discussed. The storage tests is just one component of the USAF Phillips Laboratory Nickel Hydrogen IPV Test Program. The plan was to store cells for a defined period and cycle matching cells to determine the effect on cycle life. The storage period was completed in April 95 and the cycling cells have achieved five years of real time LEO cycling. The two main objectives of the storage test are: to investigate various methods on NiH2 cells by using two different manufacturers and two different storage methods or conditions, and to determine the effect of storage method on cycle performance and cycle life by using matching cells cycling at 25% depth of discharge. The comparisons between individual cycle performance as well as cycle life are also reported. During the test the following variables has been considered: constant potential, cell current, open circuit voltage, and temperature. The results of the test are also discussed using charts and tables.

  3. Ni-H2 cell separator matrix engineering

    NASA Technical Reports Server (NTRS)

    Scott, W. E.

    1992-01-01

    This project was initiated to develop alternative separator materials to the previously used asbestos matrices which were removed from the market for health and environmental reasons. The objective of the research was to find a material or combination of materials that had the following characteristics: (1) resistant to the severe conditions encountered in Ni-H2 cells; (2) satisfactory electrical, electrolyte management, and thermal management properties to function properly; (3) environmentally benign; and (4) capable of being manufactured into a separator matrix. During the course of the research it was discovered that separators prepared from wettable polyethylene fibers along and in combination with potassium titanate pigment performed satisfactory in preliminary characterization tests. Further studies lead to the optimization of the separator composition and manufacturing process. Single ply separator sheets were manufactured with 100 percent polyethylene fibers and also with a combination of polyethylene fibers and potassium titanate pigment (PKT) in the ratio of 60 percent PKT and 40 percent fibers. A pilot paper machine was used to produce the experimental separator material by a continuous, wet laid process. Both types of matrices were produced at several different area densities (grams/sq m).

  4. Multireference and relativistic effects in NiH

    NASA Astrophysics Data System (ADS)

    Marian, Christel M.; Blomberg, Margareta R. A.; Siegbahn, Per E. M.

    1989-09-01

    Large multireference CI calculations have been performed for the ground state of NiH. The effects of relativity were investigated using both a variational (no pair) theory and perturbation theory. The largest CI calculations included up to 29 reference states and were performed at the contracted CI level. The calculated and experimental results (within parentheses) are for Re 2.76 a0 (2.76 a0), for ωe 1997 cm-1 (2003 cm-1) and for the dipole moment μ 2.32 D (2.4±0.1 D). The effects of relativity are -0.03 a0, +60 cm-1 and -0.3 D, respectively. The effects of going from a reference selection threshold of 0.05 to a selection threshold of 0.02 and a different set of CASSCF orbitals was before applying Davidson's correction +0.07 a0 for Re and about +30 cm-1 for ωe, and after applying this correction +0.06 a0 and -80 cm-1, respectively. The most accurate results for the dipole moment was obtained using the multireference ACPF method.

  5. Kids Create Healthy Comics | NIH MedlinePlus the Magazine

    MedlinePlus

    ... information resources, and educate their peers. The National Library of Medicine (NLM) is supporting this new "Health Information Literacy Project," developed by the South Carolina Area Health ...

  6. DoD–NCCAM/NIH Workshop on Acupuncture for Treatment of Acute Pain

    PubMed Central

    Belard, Jean Louis; Glowa, John; Khalsa, Partap; Weber, Wendy; Huntley, Kristen

    2013-01-01

    Abstract The Department of Defense (DoD) and the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health (NIH) cosponsored a workshop that explored the possible benefits of acupuncture treatment for acute pain. One goal of the workshop was to establish a roadmap to building an evidence base on that would indicate whether acupuncture is helpful for treating active-duty military personnel experiencing acute pain. The workshop highlighted brief presentations on the most current research on acupuncture and acute pain mechanisms. The impact of various modifiers (stress, genetics, population, phenotypes, etc.) on acute pain pathways and response to acupuncture treatment was discussed. Additional presentations focused on common neural mechanisms, an overview of real-world experience with using acupuncture to treat traumatic acute pain, and best tools and methods specific for acupuncture studies. Three breakout groups addressed the gaps, opportunities, and barriers to acupuncture use for acute pain in military and trauma settings. Different models of effectiveness research and optimal research designs for conducting trials in acute traumatic pain were also discussed. PMID:23020611

  7. Herpes - resources

    MedlinePlus

    Genital herpes - resources; Resources - genital herpes ... following organizations are good resources for information on genital herpes : March of Dimes -- www.marchofdimes.com/pregnancy/complications- ...

  8. Resource Economics

    NASA Astrophysics Data System (ADS)

    Conrad, Jon M.

    2000-01-01

    Resource Economics is a text for students with a background in calculus, intermediate microeconomics, and a familiarity with the spreadsheet software Excel. The book covers basic concepts, shows how to set up spreadsheets to solve dynamic allocation problems, and presents economic models for fisheries, forestry, nonrenewable resources, stock pollutants, option value, and sustainable development. Within the text, numerical examples are posed and solved using Excel's Solver. These problems help make concepts operational, develop economic intuition, and serve as a bridge to the study of real-world problems of resource management. Through these examples and additional exercises at the end of Chapters 1 to 8, students can make dynamic models operational, develop their economic intuition, and learn how to set up spreadsheets for the simulation of optimization of resource and environmental systems. Book is unique in its use of spreadsheet software (Excel) to solve dynamic allocation problems Conrad is co-author of a previous book for the Press on the subject for graduate students Approach is extremely student-friendly; gives students the tools to apply research results to actual environmental issues

  9. Profiling the NIH Small Molecule Repository for Compounds That Generate H2O2 by Redox Cycling in Reducing Environments

    PubMed Central

    2010-01-01

    We have screened the Library of Pharmacologically Active Compounds (LOPAC) and the National Institutes of Health (NIH) Small Molecule Repository (SMR) libraries in a horseradish peroxidase–phenol red (HRP-PR) H2O2 detection assay to identify redox cycling compounds (RCCs) capable of generating H2O2 in buffers containing dithiothreitol (DTT). Two RCCs were identified in the LOPAC set, the ortho-naphthoquinone β-lapachone and the para-naphthoquinone NSC 95397. Thirty-seven (0.02%) concentration-dependent RCCs were identified from 195,826 compounds in the NIH SMR library; 3 singleton structures, 9 ortho-quinones, 2 para-quinones, 4 pyrimidotriazinediones, 15 arylsulfonamides, 2 nitrothiophene-2-carboxylates, and 2 tolyl hydrazides. Sixty percent of the ortho-quinones and 80% of the pyrimidotriazinediones in the library were confirmed as RCCs. In contrast, only 3.9% of the para-quinones were confirmed as RCCs. Fifteen of the 251 arylsulfonamides in the library were confirmed as RCCs, and since we screened 17,868 compounds with a sulfonamide functional group we conclude that the redox cycling activity of the arylsulfonamide RCCs is due to peripheral reactive enone, aromatic, or heterocyclic functions. Cross-target queries of the University of Pittsburgh Drug Discovery Institute (UPDDI) and PubChem databases revealed that the RCCs exhibited promiscuous bioactivity profiles and have populated both screening databases with significantly higher numbers of active flags than non-RCCs. RCCs were promiscuously active against protein targets known to be susceptible to oxidation, but were also active in cell growth inhibition assays, and against other targets thought to be insensitive to oxidation. Profiling compound libraries or the hits from screening campaigns in the HRP-PR H2O2 detection assay significantly reduce the timelines and resources required to identify and eliminate promiscuous nuisance RCCs from the candidates for lead optimization. PMID:20070233

  10. Frontiers in glycomics: bioinformatics and biomarkers in disease. An NIH white paper prepared from discussions by the focus groups at a workshop on the NIH campus, Bethesda MD (September 11-13, 2006).

    PubMed

    Packer, Nicolle H; von der Lieth, Claus-Wilhelm; Aoki-Kinoshita, Kiyoko F; Lebrilla, Carlito B; Paulson, James C; Raman, Rahul; Rudd, Pauline; Sasisekharan, Ram; Taniguchi, Naoyuki; York, William S

    2008-01-01

    Key issues relating to glycomics research were discussed after the workshop entitled "Frontiers in Glycomics: Bioinformatics and Biomarkers in Disease" by two focus groups nominated by the organizers. The groups focused on two themes: (i) glycomics as the new frontier for the discovery of biomarkers of disease and (ii) requirements for the development of informatics for glycomics and glycobiology. The mandate of the focus groups was to build consensus on these issues and develop a summary of findings and recommendations for presentation to the NIH and the greater scientific community. A list of scientific priorities was developed, presented, and discussed at the workshops. Additional suggestions were solicited from workshop participants and collected using the workshop mailing list. The results are summarized in this White Paper, authored by the co-chairs of the focus groups. PMID:18095367

  11. ABSL-4 Aerobiology Biosafety and Technology at the NIH/NIAID Integrated Research Facility at Fort Detrick

    PubMed Central

    Lackemeyer, Matthew G.; de Kok-Mercado, Fabian; Wada, Jiro; Bollinger, Laura; Kindrachuk, Jason; Wahl-Jensen, Victoria; Kuhn, Jens H.; Jahrling, Peter B.

    2014-01-01

    The overall threat of a viral pathogen to human populations is largely determined by the modus operandi and velocity of the pathogen that is transmitted among humans. Microorganisms that can spread by aerosol are considered a more challenging enemy than those that require direct body-to-body contact for transmission, due to the potential for infection of numerous people rather than a single individual. Additionally, disease containment is much more difficult to achieve for aerosolized viral pathogens than for pathogens that spread solely via direct person-to-person contact. Thus, aerobiology has become an increasingly necessary component for studying viral pathogens that are naturally or intentionally transmitted by aerosol. The goal of studying aerosol viral pathogens is to improve public health preparedness and medical countermeasure development. Here, we provide a brief overview of the animal biosafety level 4 Aerobiology Core at the NIH/NIAID Integrated Research Facility at Fort Detrick, Maryland, USA. PMID:24402304

  12. Developable resources

    SciTech Connect

    Hunt, R.T.; Hunt, J.M.

    1995-01-01

    In the United States, it has become the conventional wisdom that all developable conventional hydropower resources have been exhausted. Studies by the US Department of Energy (DOE) and other agencies find differently. The root of disagreement may lie in the definition of what is developable. Environmental special interest groups now define developable hydropower sites as those having zero effect on the environment. As a result they conclude there are no additional developable hydropower sites. By contrast, the definition used by DOE and others is broader as it balances economic, technical, and environmental factors in accordance with the Federal Power Act.

  13. The INTELSAT Experience with Reconditioning of NiH2 Batteries

    NASA Technical Reports Server (NTRS)

    Scalici, Frank; Dunnet, Andrew; Xu, Daphne

    1997-01-01

    INTELSAT has been reconditioning NiH2 batteries since 1983 when the INTELSAT V F-6 geosynchronous communications satellite was launched. This was the first commercial use of NiH2 batteries. INTELSAT has continued this practice on all 46 NiH2 batteries it has operated in-orbit. The batteries are of several types including the classic INTELSAT cell, the HAC re-circulating design, and the Gates Mantech design. Reconditioning is performed twice each year, prior to the Eclipse Season. At this time Water Migration problems, if present, are dealt with. Temperature limits are imposed for the discharge and charge cycles as a safety precaution. In support of in-orbit operations, it is INTELSAT's practice to perform ground based life tests. In-orbit data and ground tests results are presented and the benefits of reconditioning noted.

  14. Calculated electric dipole moment of NiH X2Delta

    NASA Technical Reports Server (NTRS)

    Walch, S.; Bauschlicher, C. W., Jr.; Langhoff, S. R.

    1985-01-01

    A calculated dipole moment of 2.39 D at R sub e = 2.79 a sub 0 is reported, obtained from complete active space SCF/configuration interaction calculations plus one natural orbital iteration. The calculation is in good agreement with the experimental value of 2.4 + or - 0.1 D measured for the lowest vibrational level. In agreement with Gray et al. (1985), it is found that the dipole moment is strongly correlated with the 3d electron population; the good agreement with experiment thus provides verification of the mixed state model of NiH. It is concluded that the electric dipole moment of NiH is a sensitive test of the quality of the NiH wave function.

  15. An analysis of the NIH-supported sickle cell disease research portfolio.

    PubMed

    Gavini, Nara; Hoots, W Keith; Mensah, George A; Hanspal, Manjit

    2015-02-01

    Sickle cell disease (SCD), an inherited blood disorder is due to a single amino acid substitution on the beta chain of hemoglobin, and is characterized by anemia, severe infections, acute and chronic pain, and multi-organ damage. The National Institutes of Health (NIH) is dedicated to support basic, translational and clinical science research to improve care and ultimately, to find a cure for SCD that causes such suffering. This report provides a detailed analysis of grants funded by the NIH for SCD research in Fiscal Years 2007 through 2013. During this period, the NIH supported 247 de novo grants totaling $272,210,367 that address various aspects of SCD. 83% of these funds supported research project grants investigating the following 5 scientific themes: Pathology of Sickle Red Blood Cells; Globin Gene Expression; Adhesion and Vascular Dysfunction; Neurological Complications and Organ-specific Dysfunction; and Pain Management and Intervention. The remaining 17% of total funds supported career development and training grants; Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants; large Center grants; and Conference grants. Further analysis showed that the National Heart, Lung, and Blood Institute (NHLBI) is the largest funder of SCD research within NIH with 67% of total grants, contributing 77% of total funds; followed by the National Institute for Digestive Diseases and Kidney (NIDDK) that is funding 19% of grants, contributing 13% of total funds. The remaining 14% of grants totaling 10% of the funds were supported by all other NIH Institutes/Centers (ICs) combined. In summary, the NIH is using multiple funding mechanisms to support a sickle cell disease research agenda that is intended to advance the detection, treatment, and cure of this debilitating genetic disease. PMID:25466208

  16. NIH Director's Pioneer Awards: could the selection process be biased against women?

    PubMed

    Carnes, Molly; Geller, Stacie; Fine, Eve; Sheridan, Jennifer; Handelsman, Jo

    2005-10-01

    One of the first National Institutes of Health (NIH) Roadmap initiatives to be launched was the Director's Pioneer Award. This award was established to "identify and fund investigators of exceptionally creative abilities and diligence, for a sufficient term (five years) to allow them to develop and test far-ranging ideas." Nine excellent scientists were chosen as NIH Pioneers, but the selection of all men is at odds with the percentage of women receiving doctoral degrees for the past three decades, serving as principal investigators on NIH research grants, and achieving recognition as scientific innovators in non-NIH award competitions. The absence of women Pioneers provokes the following question: In the context of extant research on the impact of gender-based assumptions on evaluation of men and women in traditionally male fields, such as science, were there aspects about the process of nomination, evaluation, and selection that inadvertently favored men? We present evidence to suggest that women scientists would be disadvantaged by the following components of the NIH Director's Pioneer Award initiative: (1) time pressure placed on evaluators, (2) absence of face-to-face discussion about applicants, (3) ambiguity of performance criteria, given the novelty of the award, combined with an emphasis on subjective assessment of leadership, potential achievements rather than actual accomplishments, and risk taking, (4) emphasis on self-promotion, (5) weight given to letters of recommendation, and (6) the need for finalists to make a formal, in-person presentation in which the individual and not his or her science was the focus of evaluation. We offer an analysis of this process to encourage the NIH to embark on self-study and to educate all reviewers regarding an evidence-based approach to gender and evaluation. PMID:16232100

  17. Recent advances in Ni-H2 technology at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Gonzalezsanabria, O. D.; Britton, D. L.; Smithrick, J. J.; Reid, M. A.

    1986-01-01

    The NASA Lewis Research Center has concentrated its efforts on advancing the Ni-H2 system technology for low Earth orbit applications. Component technology as well as the design principles were studied in an effort to understand the system behavior and failure mechanisms in order to increase performance and extend cycle life. The design principles were previously addressed. The component development is discussed, in particular the separator and nickel electrode and how these efforts will advance the Ni-H2 system technology.

  18. Characteristics of storage related capacity loss in Ni/H2 cells

    NASA Technical Reports Server (NTRS)

    Vaidyanathan, Hari

    1993-01-01

    The changes in the capacity, voltage and pressure profile of flight configuration Ni/H2 cells when they are stored for extended periods is examined. The Ni/H2 cells exhibit capacity fade phenomenon regardless of their design when they are stored at room temperature. Capacity loss also occurs if old cells (5 years old) are stored in a very low rate trickle charge (C/200 rate) condition. A periodic recharge technique leads to pressure rise in the cells. Conventional trickle charge (C/100 rate) helps in minimizing or eliminating the second plateau which is one of the characteristics of the capacity fade phenomenon.

  19. Evaluating the NIH Library Editing Service: Pilot Study Used to Analyze Service Impact

    PubMed Central

    Clark, Cindy; Sullivan, Brigit

    2014-01-01

    Evidence-based librarianship drives initiatives and priorities in today’s research centers. To evaluate the effectiveness of the National Institutes of Health (NIH) Library’s Editing Service, librarians conducted a pilot study comparing edited manuscripts with the published versions. Using a random number generator, five published journal articles were chosen for evaluation from a pool of NIH manuscripts (n=147) edited between January 2008 and February 2012. A rubric delineating categories of frequently-checked writing elements was used to facilitate quantitative analysis. Findings showed that 84% of editors’ suggestions were accepted for three of the published papers that were submitted to the originally intended journal. PMID:25530651

  20. Morrison Receives NIH Award for Major Ras/Raf Breakthroughs | Poster

    Cancer.gov

    By Ashley DeVine, Staff Writer Deborah Morrison, Ph.D., laboratory chief, Laboratory of Cell and Developmental Signaling, Center for Cancer Research (CCR), received an NIH Director’s Award in June “for major breakthroughs in elucidating the mechanisms of Ras/Raf signaling that will be critical for diagnosis and treatment of disease,” according to the NIH Director’s Awards Ceremony brochure. She was nominated by Ira Daar, Ph.D., senior investigator, Developmental Signal Transduction Section, Laboratory of Cell and Developmental Signaling, CCR.

  1. 75 FR 2552 - NIH State-of-the-Science Conference: Enhancing Use and Quality of Colorectal Cancer Screening

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ..., particularly breast and cervical cancer. Reasons for this disparity are complex. Unlike most other preventive... Quality of Colorectal Cancer Screening Notice is hereby given by the National Institutes of Health (NIH) of the ``NIH State-of-the-Science Conference: Enhancing Use and Quality of Colorectal...

  2. 78 FR 71624 - Submission for OMB Review; 30-Day Comment Request; Data Collection To Understand How NIH Programs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... Collection To Understand How NIH Programs Apply Methodologies To Improve Their Research Programs (MIRP... understand how NIH programs apply methodologies to improve their research programs (MIRP), 0925- NEW... for formative research activities relating to the collection of data to assist the Institute...

  3. 76 FR 61719 - Notice of a meeting of a working group of the NIH Blue Ribbon Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... HUMAN SERVICES National Institutes of Health Notice of a meeting of a working group of the NIH Blue Ribbon Panel The purpose of this notice is to inform the public about a meeting of the NIH Blue Ribbon..., Senior Health Policy Analyst, Office of Biotechnology Activities, Office of Science Policy, Office of...

  4. Colleagues Pay Tribute to Dr. Donald A.B. Lindberg, Retiring After Three Decades of NLM Leadership | NIH MedlinePlus ...

    MedlinePlus

    ... Outgoing NLM Director Dr. Donald A.B. Lindberg. Photo courtesy of Ernie Branson, NIH On March 30, ... of Don's influence and inspiration. Dr. Vivian Pinn Photo courtesy of Ernie Branson, NIH Peter Reinecke Photo ...

  5. Research jobs for recent college graduates: A comparison between traditional lab technician positions and NIH's postbaccalaureate IRTA fellowship.

    PubMed

    Herbert, J Taylor

    2003-01-01

    The features that distinguish the Postbaccalaureate IRTA experience from a normal lab tech job are the enhanced educational opportunities, greater independence, more organized social outlets and networking opportunities, life in the DC Metro area, and the NIH itself. Also, research experience looks great on a CV when applying for research jobs or graduate schools, and the NIH name and Postbaccalaureate IRTA fellowship are impressive to potential employers and admissions committees. On the other hand, lab tech jobs often require fewer commitments outside of a normal 9-to-5 work day and usually have better pay and benefits than the Postbaccalaureate IRTA fellowship. In addition, working at a specific university often carries the benefit of being closer to one's family, friends, and/or significant others. Someone who does not like cities can choose to work at a university that has ready access to the beach, mountains, or regions of the country that are more personally appealing than the Washington, DC, area. Lab tech jobs also usually require at least a two year commitment, whereas the Postbac IRTA fellowship is generally a one year commitment (possibly two). Regardless of which option you choose, you should be active in searching for a job that lets you fulfill the goals you set for yourself in the years between graduating and starting graduate or medical school. Whether those goals are to publish, get experience, save money, or just enjoy yourself, with careful questioning and circumspection, you should be able to maximize the possibility that you will meet your goals. PMID:23741203

  6. Hubble Space Telescope On-orbit NiH2 Battery Performance

    NASA Technical Reports Server (NTRS)

    Rao, Gopalakrishna M.; Krol, Stanley J., Jr.

    2002-01-01

    This paper summarizes the Hubble Space Telescope (HST) nickel-hydrogen (NiH2) battery performance from launch to the present time. Over the life of HST vehicle configuration, charge system degradation and failures together with thermal design limitations have had a significant effect on the capacity of the HST batteries. Changes made to the charge system configuration in order to protect against power system failures and to maintain battery thermal stability resulted in undercharging of the batteries. This undercharging resulted in decreased usable battery capacity as well as battery cell voltage/capacity divergence. This cell divergence was made evident during on-orbit battery capacity measurements by a relatively shallow slope of the discharge curve following the discharge knee. Early efforts to improve the battery performance have been successful. On-orbit capacity measurement data indicates increases in the usable battery capacity of all six batteries as well as improvements in the battery cell voltage/capacity divergence. Additional measures have been implemented to improve battery performance, however, failures within the HST Power Control Unit (PCU) have prevented verification of battery status. As this PCU fault prevents the execution of on-orbit capacity testing, the HST Project has based the battery capacity on trends, which utilizes previous on-orbit battery capacity test data, for science mission and servicing mission planning. The Servicing Mission 38 (SM-3B) in March 2002 replaced the faulty PCU. Following the servicing mission, on-orbit capacity test resumed. A summary of battery performance is reviewed since launch in this paper.

  7. Dealing with Diverticulitis | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Walking really does speed recovery—it gets your system moving again! That, plus good pain management, assured my recovery was excellent. “…so painful, I couldn't walk across the room.” — Sharon Ellison , Facilitator, Educational Resources for Learning Disabled Youth Washington, DC I gradually began to ...

  8. Herpes - resources

    MedlinePlus

    Genital herpes - resources; Resources - genital herpes ... The following organizations are good resources for information on genital herpes : March of Dimes -- www.marchofdimes.com/pregnancy/complications-herpes National Institute of Allergy and Infectious Disease -- ...

  9. Fungal genome resources at NCBI.

    PubMed

    Robbertse, B; Tatusova, T

    2011-09-01

    The National Center for Biotechnology Information (NCBI) is well known for the nucleotide sequence archive, GenBank and sequence analysis tool BLAST. However, NCBI integrates many types of biomolecular data from variety of sources and makes it available to the scientific community as interactive web resources as well as organized releases of bulk data. These tools are available to explore and compare fungal genomes. Searching all databases with Fungi [organism] at http://www.ncbi.nlm.nih.gov/ is the quickest way to find resources of interest with fungal entries. Some tools though are resources specific and can be indirectly accessed from a particular database in the Entrez system. These include graphical viewers and comparative analysis tools such as TaxPlot, TaxMap and UniGene DDD (found via UniGene Homepage). Gene and BioProject pages also serve as portals to external data such as community annotation websites, BioGrid and UniProt. There are many different ways of accessing genomic data at NCBI. Depending on the focus and goal of research projects or the level of interest, a user would select a particular route for accessing genomic databases and resources. This review article describes methods of accessing fungal genome data and provides examples that illustrate the use of analysis tools. PMID:22737589

  10. 42 CFR 68a.1 - What is the scope and purpose of the NIH Clinical Research Loan Repayment Program for Individuals...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What is the scope and purpose of the NIH Clinical..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS FROM DISADVANTAGED BACKGROUNDS (CR-LRP) § 68a.1 What is the scope and purpose of the NIH...

  11. 42 CFR 68a.1 - What is the scope and purpose of the NIH Clinical Research Loan Repayment Program for Individuals...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What is the scope and purpose of the NIH Clinical..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR INDIVIDUALS FROM DISADVANTAGED BACKGROUNDS (CR-LRP) § 68a.1 What is the scope and purpose of the NIH...

  12. 42 CFR 68.11 - What does an individual have to do in return for loan repayments received under the NIH LRPs?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... loan repayments received under the NIH LRPs? 68.11 Section 68.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH... received under the NIH LRPs? Individuals must agree to: (a) Engage in qualified research for the...

  13. 42 CFR 68.11 - What does an individual have to do in return for loan repayments received under the NIH LRPs?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... loan repayments received under the NIH LRPs? 68.11 Section 68.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH... received under the NIH LRPs? Individuals must agree to: (a) Engage in qualified research for the...

  14. Guidance from an NIH workshop on designing,implementing, and reporting clinical studies of soy interventions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The NIH sponsored a scientific workshop, “Soy Protein/Isoflavone Research: Challenges in Designing and Evaluating Intervention Studies,” July 28–29, 2009. The workshop goal was to provide guidance for the next generation of soy protein/isoflavone human research. Session topics included population ex...

  15. NIH Courts Younger Researchers, Even as It Debates How Far to Go

    ERIC Educational Resources Information Center

    Basken, Paul

    2012-01-01

    On the surface, a gathering held for young research faculty last week at Cold Spring Harbor Laboratory was a clear expression of determination by the National Institutes of Health (NIH) to help them compete for grants. The agency fears that continued Congressional budget cuts, combined with the growing number of scientists who work later into…

  16. DCP Leading NIH Glycoscience Common Fund Program; Funding Opportunities Open | Division of Cancer Prevention

    Cancer.gov

    NCI's Division of Cancer Prevention is a leading participant for a key initiative in the National Institutes of Health (NIH) Glycoscience Common Fund program. This program supports development of accessible and affordable new tools and technologies for studying the role complex carbohydrates in health and disease. |

  17. Accelerating Research Productivity in Social Work Programs: Perspectives on NIH's Postdoctoral T32 Research Training Mechanism

    ERIC Educational Resources Information Center

    Matthieu, Monica M.; Bellamy, Jennifer L.; Pena, Juan B.; Scott, Lionel D., Jr.

    2008-01-01

    This article describes the experiences of four social work researchers who pursued an alternative career path immediately following their doctorate in social work by accepting a postdoctoral training fellowship funded by the National Institutes of Health (NIH). As schools of social work look for creative ways to build research capacity, this…

  18. 77 FR 41191 - Proposed Collection; Comment Request: Effectiveness of the NIH Curriculum Supplements Programs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ...In compliance with the requirements of section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, for opportunity for public comment on proposed data collection projects, the Office of Science Education, the National Institutes of Health (NIH), will publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget (OMB) for review and approval. Proposed......

  19. Effect of Handling, Storage and Cycling on Ni-H2 Cells: Second Plateau Phenomenon

    NASA Technical Reports Server (NTRS)

    Vaidyanathan, Hari; Rao, Gopalakrishna M.; Day, John H. (Technical Monitor)

    2000-01-01

    A viewgraph presentation outlines the effects of handling, storing, and cycling of NiH2 cells, particularly the second plateau phenomenon. Details are given on the criteria for cell selection, cell history, the second plateau capacity at C/2 discharge, and cell reversal test conditions. Tables display a gas analysis and nickel precharge.

  20. ASD: What Are Autism Spectrum Disorders? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... who is trying to play with them Training adolescents and adults with ASD in employment skills, such as writing a resume and interviewing for a job Videos and Audio About ASD from the National Institute of Mental Health (NIMH) www.nimh.nih.gov/news/media/index-autism.shtml At its website, NIMH offers ...

  1. 76 FR 30178 - Submission for OMB review; Comment Request; Process Evaluation of the NIH Roadmap Epigenomics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ...Under the provisions of Section 3507(a)(1)(D) of the Paperwork Reduction Act of 1995, the National Institute on Drug Abuse (NIDA), the National Institutes of Health (NIH), has submitted to the Office of Management and Budget (OMB) a request to review and approve the information collection listed below. This proposed information collection was previously published in the Federal Register in......

  2. 75 FR 63833 - Proposed Collection; Comment Request; the NIH-American Association for Retired Persons (AARP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... Cancer Institute (NCI), the National Institutes of Health (NIH) will publish periodic summaries of... Respondents: U.S. adults (aged 50 and over). The annual reporting burden is displayed in the table below. The.... ] Table 1--Estimates of Annual Burden Hours Average time per Instrument(s) tested Frequency of...

  3. Life after the NIH: After a Flawed Policy, What's next for Librarians and Open Access?

    ERIC Educational Resources Information Center

    Albanese, Andrew Richard

    2005-01-01

    On January 15, 2005, a standing-room-only crowd of librarians listened as a panel of experts, moderated by Columbia University's Jim Neal, voiced support for the National Institute of Health's (NIH) proposal to mandate free online access to the research it funds. This article briefly discusses some personal accounts where open access would have…

  4. To Your Health: NLM update transcript - NIH MedlinePlus magazine Summer 2016

    MedlinePlus

    ... National Library of Medicine (NLM). Here is what's new this week in To Your Health, a consumer health oriented podcast from NLM, that helps you use MedlinePlus to follow up on weekly topics. The new edition of NIH MedlinePlus magazine covers the Zika ...

  5. Playing Fair?: Minority Research Institutions Call for NIH to Address Funding Disparities

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2012-01-01

    When Ph.D. science and health researchers are seeking financial support for their health science studies, more often than not they apply to the federal government's National Institutes of Health (NIH) for an RO1 research grant, which boosts a project's standing in the research community as well as the career of the applicant. Even before the NIH…

  6. NIH's National Institute of General Medical Sciences celebrates 45 years of Discovery for Health

    MedlinePlus

    ... NIGMS researchers that helps extend our overall medical knowledge. Jeremy M. Berg, Ph.D. NIGMS Director Photo courtesy of NIH/ NIGMS True or False One of the valuable aspects of basic research is the discovery of new, previously unimagined scientific connections. For example: ...

  7. Healthy Aging with Go4Life® | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn JavaScript on. Feature: Healthy Aging Healthy Aging with Go4Life ® Past Issues / Winter 2015 Table of Contents Go4Life from the National Institute on Aging at NIH is a national exercise and physical ...

  8. The National Institute of Biomedical Imaging and Bioengineering and NIH grant process: an overview.

    PubMed

    Wolbarst, Anthony B; Hendee, William R

    2007-01-01

    The National Institutes of Health (NIH) comprise the largest single source of funding in the world for the support of biomedical research. Much of the work of the NIH focuses on the elucidation of fundamental biophysical, biochemical, and biologic aspects of the molecular, cellular, and tissue processes underlying both healthy and diseased states of biologic systems and on the development of cures for the latter. In 2000, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) was created with a somewhat different focus: Rather than concentration on a specific organ system or category of disease, the primary objective of the NIBIB is the advancement of technologies and tools that contribute to all aspects of biomedical research and health care delivery, especially in the imaging sciences and bioengineering. This article provides an overview of the ways in which NIH funds research, with an emphasis on NIBIB support of biomedical imaging. It is intended for radiologists, radiation oncologists, medical physicists, and other readers of this journal, especially those with limited experience in the complex process of obtaining NIH grant support. PMID:17185660

  9. The NIH R03 Award: An Initial Funding Step for Social Work Researchers

    ERIC Educational Resources Information Center

    Langhorst, Diane M.; Svikis, Dace S.

    2007-01-01

    Social workers in academic and agency settings have the opportunity to do funded research using the National Institutes of Health (NIH) R03 small grant mechanism designed for discrete, clearly defined projects that can be completed within a 1- to 2-year time period with limited funding. This article describes the R03 mechanism and provides a guide…

  10. Human c-fgr induces a monocyte-specific enzyme in NIH 3T3 cells

    SciTech Connect

    Inoue, Kazushi; Akiyama, Tetsu; Toyoshima, Kumao ); Wongsasant, Budsaba )

    1991-12-01

    The mutant c-fgr protein (p58{sup c-fgr/F523}) containing Phe-523 instead of Tyr-523 exhibited transforming activity in NIH 3T3 cells like other protein-tyrosine kinases of the src family, but normal p58{sup c-fgr} (p58{sup c-fgr/wt}) did not. The mutant protein showed tyrosine kinase activity threefold higher than that of the normal protein in vitro. Surprisingly, transfection of the normal c-fgr gene into NIH 3T3 cells resulted in induction of sodium fluoride (NaF)-sensitive {alpha}-naphthyl butyrate esterase ({alpha}-NBE), marker enzyme of cells of monocytic origin, which was not induced in v-src-, v-fgr-, or lyn-transfected NIH 3T3 cells. The NaF-sensitive {alpha}-NBE induced in c-fgr transfectants was shown by isoelectric focusing to have a pI of 5.2 to 5.4, a range which was the same as those for thioglycolate-induced murine peritoneal macrophages and 1{alpha}, 25-dihydroxyvitamin D{sub 3}-treated WEHI-3B cells. Immunoblotting studies with antophosphotyrosine antibodies revealed that 58-, 62-, 75-, 120-, 200-, and 230-kDa proteins were commonly phosphorylated at tyrosine residues in NIH 3T3 cells transfected with normal and mutated c-fgr, while 95-kDa protein was significantly phosphorylated at tyrosine residues in NIH 3T3 cells transfected with normal and mutated c-fgr, while 95-kDa protein was significantly phosphorylated at tyrosine residues in cells transfected with the mutated c-fgr. These findings suggest that tyrosine phosphorylation of specific cellular substrate proteins is important in induction of NaF-sensitive {alpha}-NBE and cell transformation by p58{sup c-fgr}.

  11. Kentucky Department for Natural Resources and Environmental Protection permit application for air contaminant source: SRC-I demonstration plant, Newman, Kentucky. Supplement I. [Additional information on 38 items requested by KY/DNREP

    SciTech Connect

    Pearson, Jr., John F.

    1981-02-13

    In response to a letter from KY/DNREP, January 19, 1981, ICRC and DOE have prepared the enclosed supplement to the Kentucky Department for Natural Resources and Environmental Protection Permit Application for Air Contaminant Source for the SRC-I Demonstration Plant. Each of the 38 comments contained in the letter has been addressed in accordance with the discussions held in Frankfort on January 28, 1981, among representatives of KY/DNREP, EPA Region IV, US DOE, and ICRC. The questions raised involve requests for detailed information on the performance and reliability of proprietary equipment, back-up methods, monitoring plans for various pollutants, composition of wastes to flares, emissions estimates from particular operations, origin of baseline information, mathematical models, storage tanks, dusts, etc. (LTN)

  12. Act for Better Child Care Services of 1988. Report from the Committee on Labor and Human Resources Together with Additional Views (To Accompany S. 1885). 100th Congress, 2nd Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    The Act for Better Child Care Services of 1988, additional views of members of the United States Senate, and related materials are reported. The purpose of the Act is to increase the availability, affordability, and quality of child care throughout the nation. The legislation provides direct financial assistance to low-income and working families…

  13. What is Migraine? | NIH MedlinePlus the Magazine

    MedlinePlus

    ... person to person. Triggers include sudden changes in weather or environment, too much or not enough sleep, ... by hormonal shifts in addition to stress and weather changes." Duvick says diet is also a factor, ...

  14. Protect Yourself Against HPV | NIH MedlinePlus the Magazine

    MedlinePlus

    ... In addition, the vaccines are recommended for teen boys and girls not yet vaccinated, young women through age 26, and young men through age 21. The vaccines are also suggested for gay and bisexual men and certain people with weakened ...

  15. SIPSEY WILDERNESS AND ADDITIONS, ALABAMA.

    USGS Publications Warehouse

    Schweinfurth, Stanley P.; Mory, Peter C.

    1984-01-01

    On the basis of geologic, geochemical, and mineral surveys the Sipsey Wilderness and additions are deemed to have little promise for the occurrence of metallic mineral resources. Although limestone, shale, and sandstone resources that occur in the area are physically suitable for a variety of uses, similar materials are available outside the area closer to transportation routes and potential markets. A small amount of coal has been identified in the area, occurring as nonpersistent beds less than 28 in. thick. Oil and (or) natural gas resources may be present if suitable structural traps exist in the subsurface. Therefore, the area has a probable oil and gas potential. Small amounts of asphaltic sandstone and limestone, commonly referred to as tar sands, may also occur in the subsurface. 5 refs.

  16. Earth Resources

    ERIC Educational Resources Information Center

    Brewer, Tom

    1970-01-01

    Reviews some of the more concerted, large-scale efforts in the earth resources areas" in order to help the computer community obtain insights into the activities it can jointly particpate in withthe earth resources community." (Author)

  17. Breastfeeding - resources

    MedlinePlus

    Resources - breastfeeding ... The following organizations are good resources for information on breastfeeding and breastfeeding problems : La Leche League International Inc. -- www.lalecheleague.org March of Dimes -- www.marchofdimes.com/ ...

  18. SIDS - resources

    MedlinePlus

    Resources - SIDS ... The following organizations are good resources for information on SIDS : American SIDS Institute -- www.sids.org Centers for Disease Control and Prevention -- www.cdc.gov/sids National ...

  19. Scoliosis - resources

    MedlinePlus

    Resources - scoliosis ... The following organizations are good resources for information on scoliosis : American Academy of Orthopedic Surgeons -- orthoinfo.aaos.org/topic.cfm?topic=A00626 National Institute of Arthritis and ...

  20. Infertility - resources

    MedlinePlus

    Resources - infertility ... The following organizations are good resources for information on infertility : Centers for Disease Control and Prevention -- www.cdc/gov/reproductivehealth/infertility March of Dimes -- www.marchofdimes.com/ ...

  1. Psoriasis - resources

    MedlinePlus

    Resources - psoriasis ... The following organizations are good resources for information about psoriasis : American Academy of Dermatology -- www.aad.org/skin-conditions/dermatology-a-to-z/psoriasis National Institute of ...

  2. Alcoholism - resources

    MedlinePlus

    Resources - alcoholism ... The following organizations are good resources for information on alcoholism : Alcoholics Anonymous -- www.aa.org Al-Anon/Alateen -- www.al-anon.org/home National Institute on Alcohol ...

  3. Incontinence - resources

    MedlinePlus

    Resources - incontinence ... The following organizations are good resources for information on incontinence. Fecal incontinence : The American Congress of Obstetricians and Gynecologists -- www.acog.org/~/media/for%20patients/faq139.ashx ...

  4. Cancer - resources

    MedlinePlus

    Resources - cancer ... The following organizations are good resources for information on cancer : American Cancer Society -- www.cancer.org Cancer Care -- www.cancercare.org National Cancer Institute -- www.cancer.gov

  5. Lupus - resources

    MedlinePlus

    Resources - lupus ... The following organizations are good resources for information on systemic lupus erythematosus : The Lupus Foundation of America -- www.lupus.org The National Institute of Arthritis and Musculoskeletal ...

  6. ALS - resources

    MedlinePlus

    Resources - ALS ... The following organizations are good resources for information on amyotrophic lateral sclerosis : Muscular Dystrophy Association -- mda.org/disease/amyotrophic-lateral-sclerosis National Amyotrophic Lateral Sclerosis (ALS) Registry -- ...

  7. Blindness - resources

    MedlinePlus

    Resources - blindness ... The following organizations are good resources for information on blindness : American Foundation for the Blind -- www.afb.org Foundation Fighting Blindness -- www.blindness.org National Eye Institute -- ...

  8. Scleroderma - resources

    MedlinePlus

    Resources - scleroderma ... The following organizations are good resources for information on scleroderma : American College of Rheumatology -- www.rheumatology.org/practice/clinical/patients/diseases_and_conditions/scleroderma.asp National Institute ...

  9. Migraine - resources

    MedlinePlus

    Resources - migraine ... The following organizations are good resources for information on migraines : American Migraine Foundation -- www.americanmigrainefoundation.org National Headache Foundation -- www.headaches.org National Institute of Neurological Disorders ...

  10. Ostomy - resources

    MedlinePlus

    Resources - ostomy ... The following organizations are good resources for information on ostomies: American Society of Colon and Rectal Surgeons -- www.fascrs.org/patients/treatments-screening and www.fascrs.org/ ...

  11. Establishment of the 3rd national standard for lot release testing of the Japanese encephalitis vaccine (Nakayama-NIH strain) in Korea.

    PubMed

    Lee, Sunmi; Moon, Hyungsil; Kim, Min Gyu; Kim, Do Keun; Chung, Hye Joo; Park, Yong Keun; Oh, Ho Jung

    2016-07-01

    In Korea, 2 inactivated Japanese encephalitis vaccines from Nakayama-NIH and Beijing-1 strain have been utilized to date. The 1(st) national standard for lot release testing of the JE vaccine was established in 2002. The 2(nd) national standard, established in 2007, is currently in use for JE vaccine (Nakayama-NIH strain) potency testing. However, the supply of this standard is expected to be exhausted by 2015, necessitating the establishment of a new national standard with quality equivalent to that of the existing standard. Quality control tests were performed to verify that the new standard candidate material was equivalent to that of the 2(nd) national standard, proving its appropriateness for potency testing of JE vaccine. In addition, based on the results of a collaborative study conducted among 4 institutions including Ministry of Food and Drug Safety, the potency of the new national standard material was determined to be 2.69 neutralizing-antibody titer (log10) per vial. Therefore, the newly established national standard material is expected to be used for the Japanese encephalitis vaccine lot release in Korea. PMID:26890572

  12. Establishment of the 3rd national standard for lot release testing of the Japanese encephalitis vaccine (Nakayama-NIH strain) in Korea

    PubMed Central

    Lee, Sunmi; Moon, Hyungsil; Kim, Min Gyu; Kim, Do Keun; Chung, Hye Joo; Park, Yong Keun; Oh, Ho Jung

    2016-01-01

    ABSTRACT In Korea, 2 inactivated Japanese encephalitis vaccines from Nakayama-NIH and Beijing-1 strain have been utilized to date. The 1st national standard for lot release testing of the JE vaccine was established in 2002. The 2nd national standard, established in 2007, is currently in use for JE vaccine (Nakayama-NIH strain) potency testing. However, the supply of this standard is expected to be exhausted by 2015, necessitating the establishment of a new national standard with quality equivalent to that of the existing standard. Quality control tests were performed to verify that the new standard candidate material was equivalent to that of the 2nd national standard, proving its appropriateness for potency testing of JE vaccine. In addition, based on the results of a collaborative study conducted among 4 institutions including Ministry of Food and Drug Safety, the potency of the new national standard material was determined to be 2.69 neutralizing-antibody titer (log10) per vial. Therefore, the newly established national standard material is expected to be used for the Japanese encephalitis vaccine lot release in Korea. PMID:26890572

  13. Welcome from Library Director Donald A.B. Lindberg, M.D. | NIH MedlinePlus the Magazine

    MedlinePlus

    ... turn Javascript on. Welcome to the NIH MedlinePlus Magazine. Past Issues / Spring 2013 Table of Contents Donald ... about their efforts to cure disease. Lastly, the magazine's lively graphics, fun quizzes and practical tips have ...

  14. NIH Researchers Find Vitamin D Binding Protein May Help to Assess Vitamin D Deficiency in African and White Americans

    MedlinePlus

    ... here Home NIH researchers find vitamin D binding protein may help to assess vitamin D deficiency in ... Americans November 21, 2013 Measuring vitamin D binding protein (VDBP) may be important for accurately determining vitamin ...

  15. The World Leader in Health Information and Innovation Celebrates 175 Years | NIH MedlinePlus the Magazine

    MedlinePlus

    ... building on the NIH campus in Bethesda, Md. Photo courtesy of jessicamarcotte.com By Dr. Donald A. ... Office, Ford's Theatre, and the Army Medical Library Photos: National Library of Medicine Lister Hill researchers use ...

  16. Dr. George Koob: "Alcohol use disorders are a major problem …" | NIH MedlinePlus the Magazine

    MedlinePlus

    ... JavaScript on. Feature: Rethinking Drinking Dr. George Koob: "Alcohol use disorders are a major problem …" Past Issues / ... is Director of the NIH's National Institute on Alcohol Abuse and Alcoholism. A renowned expert on how ...

  17. Medical Movies on the Web Debuts with Gene Kelly's "Combat Fatigue Irritability" 1945 Film | NIH MedlinePlus the ...

    MedlinePlus

    ... please turn JavaScript on. Medical Movies on the Web Debuts with Gene Kelly's "Combat Fatigue Irritability" 1945 ... of Medicine To view Medical Movies on the Web, go to: www.nlm.nih.gov/hmd/collections/ ...

  18. Model for the First NIH-funded Center of Excellence in End-of-Life Research

    PubMed Central

    Keenan, Gail M.; Kavanaugh, Karen; Wilkie, Diana J.; Bonner, Gloria; Ryan, Catherine; Fischer, Dena J.; Savage, Teresa; Choi, Heeseung; Burgener, Sandy C.; Foreman, Marquis D.; Yan, Han

    2013-01-01

    Centers of excellence are widely acknowledged as a mechanism to promote scientific advances in a particular field of science, but until recently there have been no end-of-life or palliative care research centers funded by the National Institutes of Health (NIH). The purpose of this article is to describe aims, framework, and organizational structure of the first NIH-funded Center of Excellence on end-of-life research, the Center for End-of-Life Transition Research (CEoLTR), and the advances in end-of-life research that the CEoLTR will facilitate. The teams of researchers involved in the CEoLTR have grown impressively since it was funded in 2007. Collectively, the teams are on target to accomplish all of the original goals for this five year award. PMID:23762014

  19. From the NIH: A Systems Approach to Increasing the Diversity of the Biomedical Research Workforce.

    PubMed

    Valantine, Hannah A; Lund, P Kay; Gammie, Alison E

    2016-01-01

    The National Institutes of Health (NIH) is committed to attracting, developing, and supporting the best scientists from all groups as an integral part of excellence in training. Biomedical research workforce diversity, capitalizing on the full spectrum of skills, talents, and viewpoints, is essential for solving complex human health challenges. Over the past few decades, the biomedical research workforce has benefited from NIH programs aimed at enhancing diversity. However, there is considerable room for improvement, particularly at the level of independent scientists and within scientific leadership. We provide a rationale and specific opportunities to develop and sustain a diverse biomedical research workforce through interventions that promote the successful transitions to different stages on the path toward completion of training and entry into the biomedical workforce. PMID:27587850

  20. From the NIH: A Systems Approach to Increasing the Diversity of the Biomedical Research Workforce

    PubMed Central

    Valantine, Hannah A.; Lund, P. Kay; Gammie, Alison E.

    2016-01-01

    The National Institutes of Health (NIH) is committed to attracting, developing, and supporting the best scientists from all groups as an integral part of excellence in training. Biomedical research workforce diversity, capitalizing on the full spectrum of skills, talents, and viewpoints, is essential for solving complex human health challenges. Over the past few decades, the biomedical research workforce has benefited from NIH programs aimed at enhancing diversity. However, there is considerable room for improvement, particularly at the level of independent scientists and within scientific leadership. We provide a rationale and specific opportunities to develop and sustain a diverse biomedical research workforce through interventions that promote the successful transitions to different stages on the path toward completion of training and entry into the biomedical workforce. PMID:27587850