Science.gov

Sample records for additive selection guidance

  1. 36 CFR 1290.7 - Additional guidance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 1290.7 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION JFK... ASSASSINATION RECORDS COLLECTION ACT OF 1992 (JFK ACT) § 1290.7 Additional guidance. (a) A government agency, office, or entity includes, for purposes of interpreting and implementing the JFK Act, all current,...

  2. 9 CFR 392.9 - Availability of additional guidance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Availability of additional guidance. 392.9 Section 392.9 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING §...

  3. 9 CFR 392.9 - Availability of additional guidance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Availability of additional guidance. 392.9 Section 392.9 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING §...

  4. 9 CFR 392.9 - Availability of additional guidance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Availability of additional guidance. 392.9 Section 392.9 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING §...

  5. 32 CFR Appendix A to Part 155 - Additional Procedural Guidance

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Guidance 1. When the DISCO cannot affirmatively find that it is clearly consistent with the national... processing the case, deny issuance of the requested security clearance, and direct the DISCO to revoke any... of the SOR and transmittal to the Director for notification of the DISCO for appropriate action....

  6. 32 CFR Appendix A to Part 155 - Additional Procedural Guidance

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Guidance 1. When the DISCO cannot affirmatively find that it is clearly consistent with the national... processing the case, deny issuance of the requested security clearance, and direct the DISCO to revoke any... of the SOR and transmittal to the Director for notification of the DISCO for appropriate action....

  7. 32 CFR Appendix A to Part 155 - Additional Procedural Guidance

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Guidance 1. When the DISCO cannot affirmatively find that it is clearly consistent with the national... processing the case, deny issuance of the requested security clearance, and direct the DISCO to revoke any... of the SOR and transmittal to the Director for notification of the DISCO for appropriate action....

  8. 32 CFR Appendix A to Part 155 - Additional Procedural Guidance

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Guidance 1. When the DISCO cannot affirmatively find that it is clearly consistent with the national... processing the case, deny issuance of the requested security clearance, and direct the DISCO to revoke any... of the SOR and transmittal to the Director for notification of the DISCO for appropriate action....

  9. 78 FR 21611 - Guidance for Industry on Self-Selection Studies for Nonprescription Drug Products; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... specific protocols. This guidance finalizes the draft guidance issued on September 19, 2011 (76 FR 58018... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Self-Selection Studies for... entitled ``Self-Selection Studies for Nonprescription Drug Products.'' This guidance is intended to...

  10. 77 FR 13384 - Additional Guidance on Airfare/Air Tour Price Advertisements; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ...The Department published a notice entitled ``Additional Guidance on Airfare/Air Tour Price Advertisements,'' in the Federal Register of February 27, 2012; the notice contained an incorrect address for the...

  11. 7 CFR 1951.240 - State Director's additional authorizations and guidance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false State Director's additional authorizations and guidance. 1951.240 Section 1951.240 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE...

  12. 7 CFR 1951.240 - State Director's additional authorizations and guidance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false State Director's additional authorizations and guidance. 1951.240 Section 1951.240 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE...

  13. Supplier Selection Using Weighted Utility Additive Method

    NASA Astrophysics Data System (ADS)

    Karande, Prasad; Chakraborty, Shankar

    2015-10-01

    Supplier selection is a multi-criteria decision-making (MCDM) problem which mainly involves evaluating a number of available suppliers according to a set of common criteria for choosing the best one to meet the organizational needs. For any manufacturing or service organization, selecting the right upstream suppliers is a key success factor that will significantly reduce purchasing cost, increase downstream customer satisfaction and improve competitive ability. The past researchers have attempted to solve the supplier selection problem employing different MCDM techniques which involve active participation of the decision makers in the decision-making process. This paper deals with the application of weighted utility additive (WUTA) method for solving supplier selection problems. The WUTA method, an extension of utility additive approach, is based on ordinal regression and consists of building a piece-wise linear additive decision model from a preference structure using linear programming (LP). It adopts preference disaggregation principle and addresses the decision-making activities through operational models which need implicit preferences in the form of a preorder of reference alternatives or a subset of these alternatives present in the process. The preferential preorder provided by the decision maker is used as a restriction of a LP problem, which has its own objective function, minimization of the sum of the errors associated with the ranking of each alternative. Based on a given reference ranking of alternatives, one or more additive utility functions are derived. Using these utility functions, the weighted utilities for individual criterion values are combined into an overall weighted utility for a given alternative. It is observed that WUTA method, having a sound mathematical background, can provide accurate ranking to the candidate suppliers and choose the best one to fulfill the organizational requirements. Two real time examples are illustrated to prove

  14. Fundamental Aspects of Selective Melting Additive Manufacturing Processes

    SciTech Connect

    van Swol, Frank B.; Miller, James E.

    2014-12-01

    Certain details of the additive manufacturing process known as selective laser melting (SLM) affect the performance of the final metal part. To unleash the full potential of SLM it is crucial that the process engineer in the field receives guidance about how to select values for a multitude of process variables employed in the building process. These include, for example, the type of powder (e.g., size distribution, shape, type of alloy), orientation of the build axis, the beam scan rate, the beam power density, the scan pattern and scan rate. The science-based selection of these settings con- stitutes an intrinsically challenging multi-physics problem involving heating and melting a metal alloy, reactive, dynamic wetting followed by re-solidification. In addition, inherent to the process is its considerable variability that stems from the powder packing. Each time a limited number of powder particles are placed, the stacking is intrinsically different from the previous, possessing a different geometry, and having a different set of contact areas with the surrounding particles. As a result, even if all other process parameters (scan rate, etc) are exactly the same, the shape and contact geometry and area of the final melt pool will be unique to that particular configuration. This report identifies the most important issues facing SLM, discusses the fundamental physics associated with it and points out how modeling can support the additive manufacturing efforts.

  15. 76 FR 58018 - Draft Guidance for Industry on Self-Selection Studies for Nonprescription Drug Products...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... provide recommendations to industry on the design of self- selection studies for nonprescription drug... guidance discusses general concepts to be considered in the design and conduct of a self-selection...

  16. 78 FR 68461 - Guidance for Industry: Studies To Evaluate the Utility of Anti-Salmonella Chemical Food Additives...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... Guidance for Industry: Studies to Evaluate the Utility of Anti-Salmonella Chemical Food Additives in Feeds... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Studies To Evaluate the Utility of Anti- Salmonella Chemical Food Additives in Feeds; Request for Comments AGENCY: Food and...

  17. 76 FR 82308 - Guidance for Industry: Current Good Tissue Practice and Additional Requirements for Manufacturers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    .... The guidance is intended for any HCT/P establishment that performs a manufacturing step and is... 1271, subpart E. The guidance is intended for any HCT/P establishment that performs a manufacturing... 16, 2009 (74 FR 3055), FDA announced the availability of the draft guidance of the same title...

  18. Day of Launch Profile Selection for Pad Abort Guidance

    NASA Technical Reports Server (NTRS)

    Whitley, Ryan J.

    2010-01-01

    A day of launch selection approach that involves choosing from an array of pitch profiles of varying loft was analyzed with the purpose of reducing the risk of a land landing failure during a pad abort. It was determined that selecting from three pitch profiles can reduce the number of waterline abort performance requirement failures approximately in half without compromising other performance metrics.

  19. Impact of Additional Guidance in Science Education on Primary Students' Conceptual Understanding

    ERIC Educational Resources Information Center

    Decristan, Jasmin; Hondrich, A. Lena; Büttner, Gerhard; Hertel, Silke; Klieme, Eckhard; Kunter, Mareike; Lühken, Arnim; Adl-Amini, Katja; Djakovic, Sanna-K.; Mannel, Susanne; Naumann, Alexander; Hardy, Ilonca

    2015-01-01

    A cognitive and a guidance dimension can describe the support of students' conceptual understanding in inquiry-based science education. The role of guidance for student learning has been intensively discussed. Furthermore, inquiry learning may pose particular challenges to students with low language proficiency. The present intervention in primary…

  20. The Competitive Influences of Perceptual Load and Working Memory Guidance on Selective Attention.

    PubMed

    Tan, Jinfeng; Zhao, Yuanfang; Wang, Lijun; Tian, Xia; Cui, Yan; Yang, Qian; Pan, Weigang; Zhao, Xiaoyue; Chen, Antao

    2015-01-01

    The perceptual load theory in selective attention literature proposes that the interference from task-irrelevant distractor is eliminated when perceptual capacity is fully consumed by task-relevant information. However, the biased competition model suggests that the contents of working memory (WM) can guide attentional selection automatically, even when this guidance is detrimental to visual search. An intriguing but unsolved question is what will happen when selective attention is influenced by both perceptual load and WM guidance. To study this issue, behavioral performances and event-related potentials (ERPs) were recorded when participants were presented with a cue to either identify or hold in memory and had to perform a visual search task subsequently, under conditions of low or high perceptual load. Behavioural data showed that high perceptual load eliminated the attentional capture by WM. The ERP results revealed an obvious WM guidance effect in P1 component with invalid trials eliciting larger P1 than neutral trials, regardless of the level of perceptual load. The interaction between perceptual load and WM guidance was significant for the posterior N1 component. The memory guidance effect on N1 was eliminated by high perceptual load. Standardized Low Resolution Electrical Tomography Analysis (sLORETA) showed that the WM guidance effect and the perceptual load effect on attention can be localized into the occipital area and parietal lobe, respectively. Merely identifying the cue produced no effect on the P1 or N1 component. These results suggest that in selective attention, the information held in WM could capture attention at the early stage of visual processing in the occipital cortex. Interestingly, this initial capture of attention by WM could be modulated by the level of perceptual load and the parietal lobe mediates target selection at the discrimination stage. PMID:26098079

  1. Getting the most out of additional guidance information in deformable image registration by leveraging multi-objective optimization

    NASA Astrophysics Data System (ADS)

    Alderliesten, Tanja; Bosman, Peter A. N.; Bel, Arjan

    2015-03-01

    Incorporating additional guidance information, e.g., landmark/contour correspondence, in deformable image registration is often desirable and is typically done by adding constraints or cost terms to the optimization function. Commonly, deciding between a "hard" constraint and a "soft" additional cost term as well as the weighting of cost terms in the optimization function is done on a trial-and-error basis. The aim of this study is to investigate the advantages of exploiting guidance information by taking a multi-objective optimization perspective. Hereto, next to objectives related to match quality and amount of deformation, we define a third objective related to guidance information. Multi-objective optimization eliminates the need to a-priori tune a weighting of objectives in a single optimization function or the strict requirement of fulfilling hard guidance constraints. Instead, Pareto-efficient trade-offs between all objectives are found, effectively making the introduction of guidance information straightforward, independent of its type or scale. Further, since complete Pareto fronts also contain less interesting parts (i.e., solutions with near-zero deformation effort), we study how adaptive steering mechanisms can be incorporated to automatically focus more on solutions of interest. We performed experiments on artificial and real clinical data with large differences, including disappearing structures. Results show the substantial benefit of using additional guidance information. Moreover, compared to the 2-objective case, additional computational cost is negligible. Finally, with the same computational budget, use of the adaptive steering mechanism provides superior solutions in the area of interest.

  2. Passive Sampling Methods for Contaminated Sediments: Practical Guidance for Selection, Calibration, and Implementation

    EPA Science Inventory

    This article provides practical guidance on the use of passive sampling methods(PSMs) that target the freely dissolved concentration (Cfree) for improved exposure assessment of hydrophobic organic chemicals in sediments. Primary considerations for selecting a PSM for a specific a...

  3. Guidance for Schools Selecting Antibullying Approaches: Translating Evidence-Based Strategies to Contemporary Implementation Realities

    ERIC Educational Resources Information Center

    Ansary, Nadia S.; Elias, Maurice J.; Greene, Michael B.; Green, Stuart

    2015-01-01

    This article synthesizes the current research on bullying prevention and intervention in order to provide guidance to schools seeking to select and implement antibullying strategies. Evidence-based best practices that are shared across generally effective antibullying approaches are elucidated, and these strategies are grounded in examples…

  4. 41 CFR 102-5.25 - What additional guidance concerning home-to-work transportation should Federal agencies issue?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What additional guidance concerning home-to-work transportation should Federal agencies issue? 102-5.25 Section 102-5.25 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION GENERAL...

  5. The temporal dynamics of visual working memory guidance of selective attention

    PubMed Central

    Tan, Jinfeng; Zhao, Yuanfang; Wu, Shanshan; Wang, Lijun; Hitchman, Glenn; Tian, Xia; Li, Ming; Hu, Li; Chen, Antao

    2014-01-01

    The biased competition model proposes that there is top-down directing of attention to a stimulus matching the contents of working memory (WM), even when the maintenance of a WM representation is detrimental to target relevant performance. Despite many studies elucidating that spatial WM guidance can be present early in the visual processing system, whether visual WM guidance also influences perceptual selection remains poorly understood. Here, we investigated the electrophysiological correlates of early guidance of attention by WM in humans. Participants were required to perform a visual search task while concurrently maintaining object representations in their visual WM. Behavioral results showed that response times (RTs) were longer when the distractor in the visual search task was held in WM. The earliest WM guidance effect was observed in the P1 component (90–130 ms), with match trials eliciting larger P1 amplitude than mismatch trials. A similar result was also found in the N1 component (160–200 ms). These P1 and N1 effects could not be attributed to bottom-up perceptual priming from the presentation of a memory cue, because there was no significant difference in early event-related potential (ERP) component when the cue was merely perceptually identified but not actively held in WM. Standardized Low Resolution Electrical Tomography Analysis (sLORETA) showed that the early WM guidance occurred in the occipital lobe and the N1-related activation occurred in the parietal gyrus. Time-frequency data suggested that alpha-band event-related spectral perturbation (ERSP) magnitudes increased under the match condition compared with the mismatch condition only when the cue was held in WM. In conclusion, the present study suggests that the reappearance of a stimulus held in WM enhanced activity in the occipital area. Subsequently, this initial capture of attention by WM could be inhibited by competing visual inputs through attention re-orientation, reflecting by the

  6. SU-E-J-06: Additional Imaging Guidance Dose to Patient Organs Resulting From X-Ray Tubes Used in CyberKnife Image Guidance System

    SciTech Connect

    Sullivan, A; Ding, G

    2015-06-15

    Purpose: The use of image-guided radiation therapy (IGRT) has become increasingly common, but the additional radiation exposure resulting from repeated image guidance procedures raises concerns. Although there are many studies reporting imaging dose from different image guidance devices, imaging dose for the CyberKnife Robotic Radiosurgery System is not available. This study provides estimated organ doses resulting from image guidance procedures on the CyberKnife system. Methods: Commercially available Monte Carlo software, PCXMC, was used to calculate average organ doses resulting from x-ray tubes used in the CyberKnife system. There are seven imaging protocols with kVp ranging from 60 – 120 kV and 15 mAs for treatment sites in the Cranium, Head and Neck, Thorax, and Abdomen. The output of each image protocol was measured at treatment isocenter. For each site and protocol, Adult body sizes ranging from anorexic to extremely obese were simulated since organ dose depends on patient size. Doses for all organs within the imaging field-of-view of each site were calculated for a single image acquisition from both of the orthogonal x-ray tubes. Results: Average organ doses were <1.0 mGy for every treatment site and imaging protocol. For a given organ, dose increases as kV increases or body size decreases. Higher doses are typically reported for skeletal components, such as the skull, ribs, or clavicles, than for softtissue organs. Typical organ doses due to a single exposure are estimated as 0.23 mGy to the brain, 0.29 mGy to the heart, 0.08 mGy to the kidneys, etc., depending on the imaging protocol and site. Conclusion: The organ doses vary with treatment site, imaging protocol and patient size. Although the organ dose from a single image acquisition resulting from two orthogonal beams is generally insignificant, the sum of repeated image acquisitions (>100) could reach 10–20 cGy for a typical treatment fraction.

  7. Learning guide for the terminal configured vehicle advanced guidance and control system mode select panel

    NASA Technical Reports Server (NTRS)

    Anderson, M. A.; Callahan, R.

    1981-01-01

    This learning guide is designed to assist pilots in taking the PLATO presimulator training course on the advanced guidance and control system mode select panel. The learning guide is divided into five sections. The first section, the introduction, presents the course goals, prerequisites, definition of PLATO activities, and a suggested approach to completing the course. The remaining four sections present the purpose, learning activities and summary of each lesson of the AGCS PLATO course, which consists of (1) AGCS introduction; (2) lower order modes; (3) higher order modes; and (4) an arrival route exercise.

  8. Practical guidance on characterizing availability in resource selection functions under a use-availability design

    USGS Publications Warehouse

    Northrup, Joseph M.; Hooten, Mevin B.; Anderson, Charles R., Jr.; Wittemyer, George

    2013-01-01

    Habitat selection is a fundamental aspect of animal ecology, the understanding of which is critical to management and conservation. Global positioning system data from animals allow fine-scale assessments of habitat selection and typically are analyzed in a use-availability framework, whereby animal locations are contrasted with random locations (the availability sample). Although most use-availability methods are in fact spatial point process models, they often are fit using logistic regression. This framework offers numerous methodological challenges, for which the literature provides little guidance. Specifically, the size and spatial extent of the availability sample influences coefficient estimates potentially causing interpretational bias. We examined the influence of availability on statistical inference through simulations and analysis of serially correlated mule deer GPS data. Bias in estimates arose from incorrectly assessing and sampling the spatial extent of availability. Spatial autocorrelation in covariates, which is common for landscape characteristics, exacerbated the error in availability sampling leading to increased bias. These results have strong implications for habitat selection analyses using GPS data, which are increasingly prevalent in the literature. We recommend researchers assess the sensitivity of their results to their availability sample and, where bias is likely, take care with interpretations and use cross validation to assess robustness.

  9. Guidance, navigation, and control subsystem equipment selection algorithm using expert system methods

    NASA Technical Reports Server (NTRS)

    Allen, Cheryl L.

    1991-01-01

    Enhanced engineering tools can be obtained through the integration of expert system methodologies and existing design software. The application of these methodologies to the spacecraft design and cost model (SDCM) software provides an improved technique for the selection of hardware for unmanned spacecraft subsystem design. The knowledge engineering system (KES) expert system development tool was used to implement a smarter equipment section algorithm than that which is currently achievable through the use of a standard data base system. The guidance, navigation, and control subsystems of the SDCM software was chosen as the initial subsystem for implementation. The portions of the SDCM code which compute the selection criteria and constraints remain intact, and the expert system equipment selection algorithm is embedded within this existing code. The architecture of this new methodology is described and its implementation is reported. The project background and a brief overview of the expert system is described, and once the details of the design are characterized, an example of its implementation is demonstrated.

  10. Protection against malevolent use of vehicles at Nuclear Power Plants. Vehicle barrier system selection guidance

    SciTech Connect

    Nebuda, D.T.

    1994-08-01

    This manual provides a simplified procedure for selecting land vehicle barriers that will stop the design basis vehicle threat adopted by the U.S. Nuclear Regulatory Commission. Proper selection and construction of vehicle barriers should prevent intrusion of the design basis vehicle. In addition, vital safety related equipment should survive a design basis vehicle bomb attack when vehicle barriers are properly selected, sited, and constructed. This manual addresses passive vehicle barriers, active vehicle barriers, and site design features that can be used to reduce vehicle impact velocity.

  11. Passive sampling methods for contaminated sediments: Practical guidance for selection, calibration, and implementation

    PubMed Central

    Ghosh, Upal; Driscoll, Susan Kane; Burgess, Robert M; Jonker, Michiel To; Reible, Danny; Gobas, Frank; Choi, Yongju; Apitz, Sabine E; Maruya, Keith A; Gala, William R; Mortimer, Munro; Beegan, Chris

    2014-01-01

    This article provides practical guidance on the use of passive sampling methods (PSMs) that target the freely dissolved concentration (Cfree) for improved exposure assessment of hydrophobic organic chemicals in sediments. Primary considerations for selecting a PSM for a specific application include clear delineation of measurement goals for Cfree, whether laboratory-based “ex situ” and/or field-based “in situ” application is desired, and ultimately which PSM is best-suited to fulfill the measurement objectives. Guidelines for proper calibration and validation of PSMs, including use of provisional values for polymer–water partition coefficients, determination of equilibrium status, and confirmation of nondepletive measurement conditions are defined. A hypothetical example is described to illustrate how the measurement of Cfree afforded by PSMs reduces uncertainty in assessing narcotic toxicity for sediments contaminated with polycyclic aromatic hydrocarbons. The article concludes with a discussion of future research that will improve the quality and robustness of Cfree measurements using PSMs, providing a sound scientific basis to support risk assessment and contaminated sediment management decisions. Integr Environ Assess Manag 2014;10:210–223. © 2014 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC. PMID:24288273

  12. Description of the attitude control, guidance and navigation space replaceable units for automated space servicing of selected NASA missions

    NASA Technical Reports Server (NTRS)

    Chobotov, V. A.

    1974-01-01

    Control elements such as sensors, momentum exchange devices, and thrusters are described which can be used to define space replaceable units (SRU), in accordance with attitude control, guidance, and navigation performance requirements selected for NASA space serviceable mission spacecraft. A number of SRU's are developed, and their reliability block diagrams are presented. An SRU assignment is given in order to define a set of feasible space serviceable spacecraft for the missions of interest.

  13. SEPS guidance and navigation autonomy selection via mission analysis. [Solar Electric Propulsion Stage for Space Transportation System

    NASA Technical Reports Server (NTRS)

    Causey, W.; Sohoni, V.; Shenfish, K. L.; Wallace, C. T.

    1975-01-01

    A systematic rationale for selecting a cost-effective guidance and navigation (G & N) autonomy level for the solar electric propulsion stage (SEPS) vehicle is developed. After a definition of autonomy levels, a mission analysis is performed for representative SEPS missions using realistic G & N sensor hardware. Cost data for fabricating, integrating and refurbishing onboard avionics hardware and the ground costs corresponding to each autonomy level are generated. Results are presented that indicate performance of various G & N sensor hardware sets and the dominating factors which influence G & N autonomy level selection.

  14. A review of selected chemical additives in cosmetic products.

    PubMed

    Juhász, Margit Lai Wun; Marmur, Ellen S

    2014-01-01

    The addition of chemical additives to consumer cosmetic products is a common practice to increase cosmetic effectiveness, maintain cosmetic efficacy, and produce a longer-lasting, more viable product. Recently, manufacturers have come under attack for the addition of chemicals including dioxane, formaldehyde, lead/lead acetate, parabens, and phthalate, as these additives may prove harmful to consumer health. Although reports show that these products may indeed adversely affect human health, these studies are conducted using levels of the aforementioned chemicals at much higher levels of exposure than those found in cosmetic products. When cosmeceuticals are used as per manufacturer's instructions, it is estimated that the levels of harmful additives found in these products are considerably lower than reported toxic concentrations. PMID:25052592

  15. GUIDANCE ON SELECTING AGE GROUPS FOR MONITORING AND ASSESSING CHILDHOOD EXPOSURES TO ENVIRONMENTAL CONTAMINANTS

    EPA Science Inventory

    This guidance document provides a set of early-lifestage age groups for Environmental Protection Agency scientists to consider when assessing children’s exposure to environmental contaminants and the resultant potential dose. These recommended age groups are based on current und...

  16. Prolyl isomerase Pin1 regulates axon guidance by stabilizing CRMP2A selectively in distal axons

    PubMed Central

    Balastik, Martin; Zhou, Xiao Zhen; Alberich-Jorda, Meritxell; Weissova, Romana; Žiak, Jakub; Pazyra-Murphy, Maria F.; Cosker, Katharina E; Machonova, Olga; Kozmikova, Iryna; Chen, Chun-Hau; Pastorino, Lucia; Asara, John M.; Cole, Adam; Sutherland, Calum; Segal, Rosalind A.; Lu, Kun Ping

    2015-01-01

    SUMMARY Axon guidance relies on precise translation of the gradients of the extracellular signals into local changes of cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood. Here we show that during embryonic development in growing axons low level of Semaphorin3A stimulation is buffered by the prolyl isomerase Pin1. We demonstrate, that Pin1 stabilizes CDK5-phosphorylated CRMP2A, the major isoform of CRMP2 in distal axons. Consequently, Pin1 knockdown or knockout reduces CRMP2A level specifically in distal axons and inhibits axon growth, which can be fully rescued by Pin1 or CRMP2A expression. Moreover, Pin1 knockdown or knockout increases sensitivity to Sema3A-induced growth cone collapse in vitro and in vivo leading to developmental abnormalities in axon guidance. These results identify an important isoform-specific function and regulation of CRMP2A in controlling axon growth, and uncover Pin1-catalyzed prolyl isomerization as a regulatory mechanism in axon guidance. PMID:26489457

  17. 36 CFR 1236.28 - What additional requirements apply to the selection and maintenance of electronic records storage...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-free. (c) For additional guidance on the maintenance and storage of CDs and DVDS, agencies may consult... retention. This test should verify that the magnetic computer tape media are free of permanent errors and...

  18. Additives

    NASA Technical Reports Server (NTRS)

    Smalheer, C. V.

    1973-01-01

    The chemistry of lubricant additives is discussed to show what the additives are chemically and what functions they perform in the lubrication of various kinds of equipment. Current theories regarding the mode of action of lubricant additives are presented. The additive groups discussed include the following: (1) detergents and dispersants, (2) corrosion inhibitors, (3) antioxidants, (4) viscosity index improvers, (5) pour point depressants, and (6) antifouling agents.

  19. Simultaneous attentional guidance by working-memory and selection history reveals two distinct sources of attention.

    PubMed

    Schwark, Jeremy D; Dolgov, Igor; Sandry, Joshua; Volkman, C Brooks

    2013-10-01

    Recent theories of attention have proposed that selection history is a separate, dissociable source of information that influences attention. The current study sought to investigate the simultaneous involvement of selection history and working-memory on attention during visual search. Experiments 1 and 2 used target feature probability to manipulate selection history and found significant effects of both working-memory and selection history, although working-memory dominated selection history when they cued different locations. Experiment 3 eliminated the contribution of voluntary refreshing of working-memory and replicated the main effects, although selection history became dominant. Using the same methodology, but with reduced probability cue validity, both effects were present in Experiment 4 and did not significantly differ in their contribution to attention. Effects of selection history and working-memory never interacted. These results suggest that selection history and working-memory are separate influences on attention and have little impact on each other. Theoretical implications for models of attention are discussed. PMID:23932997

  20. 77 FR 13999 - Notice of Availability and Opportunity for Comments (Establishment Guidance for the Selection of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... that prepare meat, poultry, or processed egg products to follow the criteria in the guidelines in... producing meat, poultry, and processed egg products for selecting a commercial or private laboratory...

  1. Conducting Video Research in the Learning Sciences: Guidance on Selection, Analysis, Technology, and Ethics

    ERIC Educational Resources Information Center

    Derry, Sharon J.; Pea, Roy D.; Barron, Brigid; Engle, Randi A.; Erickson, Frederick; Goldman, Ricki; Hall, Rogers; Koschmann, Timothy; Lemke, Jay L.; Sherin, Miriam Gamoran; Sherin, Bruce L.

    2010-01-01

    Focusing on expanding technical capabilities and new collaborative possibilities, we address 4 challenges for scientists who collect and use video records to conduct research in and on complex learning environments: (a) Selection: How can researchers be systematic in deciding which elements of a complex environment or extensive video corpus to…

  2. 34 CFR 658.34 - What additional factors does the Secretary consider in selecting grant recipients?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... does the Secretary consider in selecting grant recipients? In addition to applying the selection criteria in, as appropriate §§ 658.31, 658.32, and 658.33, the Secretary, to the extent practicable and... 34 Education 3 2014-07-01 2014-07-01 false What additional factors does the Secretary consider...

  3. 34 CFR 658.34 - What additional factors does the Secretary consider in selecting grant recipients?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... does the Secretary consider in selecting grant recipients? In addition to applying the selection criteria in, as appropriate §§ 658.31, 658.32, and 658.33, the Secretary, to the extent practicable and... 34 Education 3 2013-07-01 2013-07-01 false What additional factors does the Secretary consider...

  4. 34 CFR 658.34 - What additional factors does the Secretary consider in selecting grant recipients?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... does the Secretary consider in selecting grant recipients? In addition to applying the selection criteria in, as appropriate §§ 658.31, 658.32, and 658.33, the Secretary, to the extent practicable and... 34 Education 3 2012-07-01 2012-07-01 false What additional factors does the Secretary consider...

  5. 34 CFR 658.34 - What additional factors does the Secretary consider in selecting grant recipients?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... does the Secretary consider in selecting grant recipients? In addition to applying the selection criteria in, as appropriate §§ 658.31, 658.32, and 658.33, the Secretary, to the extent practicable and... 34 Education 3 2011-07-01 2011-07-01 false What additional factors does the Secretary consider...

  6. Space debris selection and optimal guidance for removal in the SSO with low-thrust propulsion

    NASA Astrophysics Data System (ADS)

    Olympio, J. T.; Frouvelle, N.

    2014-06-01

    The current paper deals with the mission design of a generic active space debris removal spacecraft. Considered space debris are all on sun-synchronous orbits. A perturbed Lambert's problem, modelling the transfer between two space debris is devised to take into account J2 perturbation, and to quickly evaluate mission scenarios. A robust approach, using techniques of global optimisation, is followed to find the optimal space debris sequence and mission strategy. Low-thrust optimisation is then performed to turn bi-impulse transfers into optimal low-thrust transfers, and refine the selected scenarios.

  7. Catheter-Based Ultrasound Applicators for Selective Prostate Ablation With MR-Guidance

    NASA Astrophysics Data System (ADS)

    Diederich, Chris J.; Ross, Anthony B.; Nau, Will H.; Butts, Kim; Rieke, Viola; Sommer, Graham

    2005-03-01

    The purpose of this study was to develop catheter-based ultrasound devices and techniques specifically for treating prostate cancer in conjunction with MRI thermal imaging to monitor and control treatment progression. Directional transurethral applicators have been designed with arrays of sectored tubular (90° active acoustic sector) or narrow planar transducer segments integrated with a flexible delivery catheter with a cooling balloon. Interstitial applicators (2.4 mm catheter diameter, 1.5 mm OD tubular transducers) with 180° active acoustic sectors have been developed specifically for transperineal implantation to treat the posterior portion of the prostate. Both heating strategies were evaluated via in vivo experiments within canine prostate. Both transurethral and interstitial treatment strategies demonstrated significant potential for selective thermal ablation of localized regions of the prostate, particularly when MRI thermal imaging is used to guide and assess treatment.

  8. The Effect of Training in Verbal Self-Guidance on the Self-Efficacy and Performance of Native North Americans in the Selection Interview

    ERIC Educational Resources Information Center

    Latham, Gary P.; Budworth, Marie-Helene

    2006-01-01

    Native North Americans ("n" = 35) received training in verbal self-guidance (VSG) designed to increase self-efficacy in a selection interview. At the end of the training program, the trainees who acquired skills in VSG had higher self-efficacy than the participants in the control group ("n" = 31) regarding their interview performance. They also…

  9. 34 CFR 386.20 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... selection criteria are used under this program? In addition to the criteria in 34 CFR 385.31(c), the... provide for an integration of theory and practice relevant to the educational objectives of the...

  10. 34 CFR 396.31 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... criteria in 34 CFR 396.30(c), the Secretary uses the following additional selection criterion to evaluate... interpreter training project and service providers; and (4) There are opportunities for individuals who are.... 771a(f))...

  11. 34 CFR 396.31 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... criteria in 34 CFR 396.30(c), the Secretary uses the following additional selection criterion to evaluate... interpreter training project and service providers; and (4) There are opportunities for individuals who are.... 771a(f))...

  12. 34 CFR 396.31 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... criteria in 34 CFR 396.30(c), the Secretary uses the following additional selection criterion to evaluate... interpreter training project and service providers; and (4) There are opportunities for individuals who are.... 771a(f))...

  13. Additive effects of pollinators and herbivores result in both conflicting and reinforcing selection on floral traits.

    PubMed

    Sletvold, Nina; Moritz, Kim K; Agren, Jon

    2015-01-01

    Mutualists and antagonists are known to respond to similar floral cues, and may thus cause opposing selection on floral traits. However, we lack a quantitative understanding of their independent and interactive effects. In a population of the orchid Gymnadenia conopsea, we manipulated the intensity of pollination and herbivory in a factorial design to examine whether both interactions influence selection on flowering phenology, floral display, and morphology. Supplemental hand-pollination increased female fitness by 31% and one-quarter of all plants were damaged by herbivores. Both interactions contributed to selection. Pollinators mediated selection for later flowering and herbivores for earlier flowering, while both selected for longer spurs. The strength of selection was similar for both agents, and their effects were additive. As a consequence, there was no. net selection on phenology, whereas selection on spur length was strong. The experimental results demonstrate that both pollinators and herbivores can markedly influence the strength of selection on flowering phenology and floral morphology, and cause both conflicting and reinforcing selection. They also indicate that the direction of selection on phenology will vary with the relative intensity of the mutualistic and antagonistic interaction, potentially resulting in both temporal and among-population variation in optimal flowering time. PMID:26236906

  14. Additional guidance for including nuclear safety equivalency in the Canister Storage Building and Cold Vacuum Drying Facility final safety analysis report

    SciTech Connect

    Garvin, L.J.

    1997-05-20

    This document provides guidance for the production of safety analysis reports that must meet both DOE Order 5480.23 and STD 3009, and be in compliance with the DOE regulatory policy that imposes certain NRC requirements.

  15. Effects of strongly selective additives on volume phase transition in gels

    NASA Astrophysics Data System (ADS)

    Uematsu, Yuki; Araki, Takeaki

    2012-07-01

    We investigate volume phase transition in gels immersed in mixture solvents, on the basis of a three-component Flory-Rehner theory. When the selectivity of the minority solvent component to the polymer network is strong, the gel tends to shrink with an increasing concentration of the additive, regardless of whether it is good or poor. This behavior originates from the difference of the additive concentration between inside and outside the gel. We also found the gap of the gel volume at the transition point can be controlled by adding the strongly selective solutes. By dissolving a strongly poor additive, for instance, the discontinuous volume phase transition can be extinguished. Furthermore, we observed that another volume phase transition occurs far from the original transition point. These behaviors can be well explained by a simplified theory neglecting the nonlinearity of the additive concentration.

  16. 34 CFR 386.20 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... selection criteria are used under this program? In addition to the criteria in 34 CFR 385.31(c), the... State-Federal rehabilitation service program. (1) The Secretary reviews each application for information... rehabilitation service program. (2) The Secretary looks for information that shows that the project can...

  17. 34 CFR 386.20 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... selection criteria are used under this program? In addition to the criteria in 34 CFR 385.31(c), the... State-Federal rehabilitation service program. (1) The Secretary reviews each application for information... rehabilitation service program. (2) The Secretary looks for information that shows that the project can...

  18. 34 CFR 386.20 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... selection criteria are used under this program? In addition to the criteria in 34 CFR 385.31(c), the... State-Federal rehabilitation service program. (1) The Secretary reviews each application for information... rehabilitation service program. (2) The Secretary looks for information that shows that the project can...

  19. 34 CFR 386.20 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... selection criteria are used under this program? In addition to the criteria in 34 CFR 385.31(c), the... State-Federal rehabilitation service program. (1) The Secretary reviews each application for information... rehabilitation service program. (2) The Secretary looks for information that shows that the project can...

  20. 34 CFR 658.34 - What additional factors does the Secretary consider in selecting grant recipients?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What additional factors does the Secretary consider in selecting grant recipients? 658.34 Section 658.34 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE...

  1. 34 CFR 388.20 - What additional selection criterion is used under this program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... criterion is used under this program? In addition to the selection criteria in 34 CFR 385.31(c), the.... (1) The Secretary reviews each application for information that shows that the need for the in-service training has been adequately justified. (2) The Secretary looks for information that shows—...

  2. 34 CFR 388.20 - What additional selection criterion is used under this program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... criterion is used under this program? In addition to the selection criteria in 34 CFR 385.31(c), the.... (1) The Secretary reviews each application for information that shows that the need for the in-service training has been adequately justified. (2) The Secretary looks for information that shows—...

  3. 34 CFR 388.20 - What additional selection criterion is used under this program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... criterion is used under this program? In addition to the selection criteria in 34 CFR 385.31(c), the.... (1) The Secretary reviews each application for information that shows that the need for the in-service training has been adequately justified. (2) The Secretary looks for information that shows—...

  4. 34 CFR 388.20 - What additional selection criterion is used under this program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... criterion is used under this program? In addition to the selection criteria in 34 CFR 385.31(c), the.... (1) The Secretary reviews each application for information that shows that the need for the in-service training has been adequately justified. (2) The Secretary looks for information that shows—...

  5. 34 CFR 388.20 - What additional selection criterion is used under this program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... criterion is used under this program? In addition to the selection criteria in 34 CFR 385.31(c), the.... (1) The Secretary reviews each application for information that shows that the need for the in-service training has been adequately justified. (2) The Secretary looks for information that shows—...

  6. Assessment of Service Delivery in Guidance and Counselling Units in Selected Secondary Schools in Eldoret Municipality, Kenya

    ERIC Educational Resources Information Center

    Owino, Elizabeth Akinyi

    2015-01-01

    This paper assesses the type of services delivered by the existing Guidance and Counselling units in secondary schools in Kenya based on a survey conducted in Eldoret Municipality in Uasin Gishu County, Kenya. The study adopted an ex-post facto research design the target population being all secondary schools in the Municipality where a sample was…

  7. Ultrasonic online monitoring of additive manufacturing processes based on selective laser melting

    NASA Astrophysics Data System (ADS)

    Rieder, Hans; Dillhöfer, Alexander; Spies, Martin; Bamberg, Joachim; Hess, Thomas

    2015-03-01

    Additive manufacturing processes have become commercially available and are particularly interesting for the production of free-formed parts. Selective laser melting allows to manufacture components by localized melting of successive layers of metal powder. In order to be able to describe and to understand the complex dynamics of selective laser melting processes more accurately, online measurements using ultrasound have been performed for the first time. In this contribution, we report on the integration of the measurement technique into the manufacturing facility and on a variety of promising monitoring results.

  8. Additive Manufacturing of Al-12Si Alloy Via Pulsed Selective Laser Melting

    NASA Astrophysics Data System (ADS)

    Chou, R.; Milligan, J.; Paliwal, M.; Brochu, M.

    2015-03-01

    Additive manufacturing (AM) of metallic materials is experiencing a research and commercialization craze in almost all industrial sectors. However, to date, AM has been limited to a small numbers of alloys. With respect to aluminum, two alloys received some attention: Al-12Si and Al-10Si-1Mg. In both cases, fully dense components have been achieved using a continuous-wave selective laser melting system. In this article, a new approach of selective laser melting using a pulsed-laser source as opposed to a continuous-wave laser is proposed. Pulse selective laser melting (P-SLM) would allow for greater control over the heat input and thus further optimization possibilities of the microstructure. P-SLM was demonstrated using the Al-12Si system. Si refinement below 200 nm was achieved throughout the component. Density up to 95% and high hardness of above 135 HV were obtained. The solidification mechanism is also explained.

  9. Modulation of orientation-selective neurons by motion: when additive, when multiplicative?

    PubMed Central

    Lüdge, Torsten; Urbanczik, Robert; Senn, Walter

    2014-01-01

    The recurrent interaction among orientation-selective neurons in the primary visual cortex (V1) is suited to enhance contours in a noisy visual scene. Motion is known to have a strong pop-up effect in perceiving contours, but how motion-sensitive neurons in V1 support contour detection remains vastly elusive. Here we suggest how the various types of motion-sensitive neurons observed in V1 should be wired together in a micro-circuitry to optimally extract contours in the visual scene. Motion-sensitive neurons can be selective about the direction of motion occurring at some spot or respond equally to all directions (pandirectional). We show that, in the light of figure-ground segregation, direction-selective motion neurons should additively modulate the corresponding orientation-selective neurons with preferred orientation orthogonal to the motion direction. In turn, to maximally enhance contours, pandirectional motion neurons should multiplicatively modulate all orientation-selective neurons with co-localized receptive fields. This multiplicative modulation amplifies the local V1-circuitry among co-aligned orientation-selective neurons for detecting elongated contours. We suggest that the additive modulation by direction-specific motion neurons is achieved through synaptic projections to the somatic region, and the multiplicative modulation by pandirectional motion neurons through projections to the apical region of orientation-specific pyramidal neurons. For the purpose of contour detection, the V1-intrinsic integration of motion information is advantageous over a downstream integration as it exploits the recurrent V1-circuitry designed for that task. PMID:24999328

  10. Guidance Matters

    ERIC Educational Resources Information Center

    Gartrell, Dan

    2005-01-01

    In this column, the author shares and comments on early childhood educators' use of guidance to foster young children's development and learning. He defines guidance as the commitment a teacher makes to teaching children how to solve their problems, rather than punishing them for having problems they haven't yet learned how to solve. The focus of…

  11. Resources for Guidance Program Improvement. Volume 2.

    ERIC Educational Resources Information Center

    Frenza, Mary C., Comp.; and Others

    This guide, for guidance personnel and teachers, is designed to provide ready access to current, practical programs, activities, and references for improving guidance programs. The resources are organized in four sections representing areas of basic concern for guidance personnel. Section 1 presents selected portions of guidance programs from…

  12. Isomeric Selective Studies of the Dominant Addition Channel in OH Initiated Oxidation of Isoprene

    NASA Astrophysics Data System (ADS)

    Ghosh, B.; Bugarin, A.; Connell, B.; North, S. W.

    2009-12-01

    We report the first isomeric selective study of the dominant isomeric pathway in the OH initiated oxidation of isoprene in the presence of O2 and NO using the Laser Photolysis-Laser Induced Fluorescence (LP-LIF) technique. The photolysis of monodeuterated/non deuterated 2-iodo-2-methyl-but-3-en-1-ol results exclusively in the dominant OH-isoprene addition product, providing important insight into the oxidation mechanism. Based on kinetic analysis of OH cycling experiments we have determined the rate constant for O2 addition to the hydroxy alkyl radical to be (1.0±0.5) × 10^(-12) cm^(3) s^(-1) and we find a value of (8.05±2.3) × 10^(-12) cm^(3) s^(-1) for the overall reaction rate constant of the hydroxy peroxy radical with NO. We also report the first clear experimental evidence of the (E-) form of the δ-hydroxyalkoxy channel through isotopic labeling experiments and quantify its branching ratio to be 0.1±0.025. Since it corresponds to missing carbon balance in isoprene oxidation, we have been able to identify some of the missing carbon balance. Since our measured isomeric selective rate constants for the dominant outer channel in OH initiated isoprene chemistry are similar to the overall rate constants derived from non isomeric kinetics, we predict that the remaining outer addition channel will have similar reactivity. We have extended this study to the OH initiated oxidation of 1,3-butadiene. We have obtained isomeric selective rate constants on the dominant channel of the butadiene oxidation chemistry and measured the branching ratio for the δ-hydroxyalkoxy channel. These results on butadiene studies will be discussed.

  13. Radiation exposure and associated risks to operating-room personnel during use of fluoroscopic guidance for selected orthopaedic surgical procedures

    SciTech Connect

    Miller, M.E.; Davis, M.L.; MacClean, C.R.; Davis, J.G.; Smith, B.L.; Humphries, J.R.

    1983-01-01

    Because of the increased use of fluoroscopic guidance techniques in certain orthopaedic surgical procedures, surgeons and other operating-room personnel who are involved in these procedures are voicing growing concern over possible associated radiation health hazards. Using thin-layer lithium fluoride chips for thermoluminescence dosimetry, we directly measured the radiation exposure encountered by the primary surgeon during seven operative procedures that were done utilizing fluoroscopic guidance techniques. Dosimetry studies were also carried out using a tissue-equivalent phantom model to determine the directions of maximum scatter radiation. These studies indicated that the standard protective apron that is commonly worn during the use of fluoroscopy provides adequate protection to most of the body; however, the surgeon is exposed to significant levels of scatter radiation to the head, neck, and hands, Dosimetry studies showed that positioning the fluoroscopic beam vertically to the fracture site of the supine patient, with the x-ray source posterior to the patient, provided the lowest levels of scatter radiation to the surgeon in the normal working position.

  14. Self-calibration of terrestrial laser scanners: selection of the best geometric additional parameters

    NASA Astrophysics Data System (ADS)

    Lerma, J. L.; García-San-Miguel, D.

    2014-05-01

    Systematic errors are present in laser scanning system observations due to manufacturer imperfections, wearing over time, vibrations, changing environmental conditions and, last but not least, involuntary hits. To achieve maximum quality and rigorous measurements from terrestrial laser scanners, a least squares estimation of additional calibration parameters can be used to model the a priori unknown systematic errors and therefore improve output observations. The selection of the right set of additional parameters is not trivial and requires laborious statistical analysis. Based on this requirement, this article presents an approach to determine the best set of additional parameters which provides the best mathematical solution based on a dimensionless quality index. The best set of additional parameters is the one which provides the maximum quality index (i.e. minimum value) for the group of observables, exterior orientation parameters and reference points. Calibration performance is tested using both a phase shift continuous wave scanner, FARO PHOTON 880, and a pulse-based time-of-flight system, Leica HDS3000. The improvement achieved after the geometric calibration is 30% for the former and 70% for the latter.

  15. External Standards or Standard Addition? Selecting and Validating a Method of Standardization

    NASA Astrophysics Data System (ADS)

    Harvey, David T.

    2002-05-01

    A common feature of many problem-based laboratories in analytical chemistry is a lengthy independent project involving the analysis of "real-world" samples. Students research the literature, adapting and developing a method suitable for their analyte, sample matrix, and problem scenario. Because these projects encompass the complete analytical process, students must consider issues such as obtaining a representative sample, selecting a method of analysis, developing a suitable standardization, validating results, and implementing appropriate quality assessment/quality control practices. Most textbooks and monographs suitable for an undergraduate course in analytical chemistry, however, provide only limited coverage of these important topics. The need for short laboratory experiments emphasizing important facets of method development, such as selecting a method of standardization, is evident. The experiment reported here, which is suitable for an introductory course in analytical chemistry, illustrates the importance of matrix effects when selecting a method of standardization. Students also learn how a spike recovery is used to validate an analytical method, and obtain a practical experience in the difference between performing an external standardization and a standard addition.

  16. Data acquisition and path selection decision making for an autonomous roving vehicle. [laser pointing control system for vehicle guidance

    NASA Technical Reports Server (NTRS)

    Shen, C. N.; YERAZUNIS

    1979-01-01

    The feasibility of using range/pointing angle data such as might be obtained by a laser rangefinder for the purpose of terrain evaluation in the 10-40 meter range on which to base the guidance of an autonomous rover was investigated. The decision procedure of the rapid estimation scheme for the detection of discrete obstacles has been modified to reinforce the detection ability. With the introduction of the logarithmic scanning scheme and obstacle identification scheme, previously developed algorithms are combined to demonstrate the overall performance of the intergrated route designation system using laser rangefinder. In an attempt to cover a greater range, 30 m to 100 mm, the problem estimating gradients in the presence of positioning angle noise at middle range is investigated.

  17. Ti-6Al-4V Additively Manufactured by Selective Laser Melting with Superior Mechanical Properties

    NASA Astrophysics Data System (ADS)

    Xu, W.; Sun, S.; Elambasseril, J.; Liu, Q.; Brandt, M.; Qian, M.

    2015-03-01

    The Achilles' heel of additively manufactured Ti-6Al-4V by selective laser melting (SLM) is its inferior mechanical properties compared with its wrought (forged) counterparts. Acicular α' martensite resulted from rapid cooling by SLM is primarily responsible for high strength but inadequate tensile ductility achieved in the as-fabricated state. This study presents a solution to eliminating the adverse effect of the nonequilibrium α' martensite. This is achieved by enabling in situ martensite decomposition into a novel ultrafine (200-300 nm) lamellar ( α + β) microstructure via the selection of an array of processing variables including the layer thickness, energy density, and focal offset distance. The resulting tensile elongation reached 11.4% while the yield strength was kept above 1100 MPa. These properties compare favorably with those of mill-annealed Ti-6Al-4V consisting of globular α and β. The fatigue life of SLM-fabricated Ti-6Al-4V with an ultrafine lamellar ( α + β) structure has approached that of the mill-annealed counterparts and is much superior to that of SLM-fabricated Ti-6Al-4V with α' martensite.

  18. Clinical characteristics and selection of treatment modality for patients with vitreomacular traction: real-world implementation of NICE guidance (TA297)

    PubMed Central

    Pritchard, Edward William James; Ilyas, Shams-Ulislam; Amar, Soha Khaled; Yang, Yit Chuin; Narendran, Nirodhini

    2016-01-01

    Aim To investigate the qualitative aspects in patient selection and the quantitative impact of disease burden in real world treatment of vitreomacular traction (VMT) and implementation of the National Institute for Health and Care Excellence (NICE) guidance (TA297). Methods A monocentric, retrospective review of consecutive patients undergoing optical coherence tomography (OCT) imaging over a 3 month period. Patients with VMT in at least one eye were identified for further data collection on laterality, visual acuity, symptoms, presence of epiretinal membrane, macular hole and treatment selection. Results A total of 3472 patients underwent OCT imaging with a total of 6878 eyes scanned. Out of 87 patients, 74 patients had unilateral VMT (38 right, 36 left) and 13 patients had bilateral VMT. Eighteen patients with unilateral VMT satisfied NICE criteria of severe sight problems in the affected eye. Eight were managed for a coexisting pathology, one refused treatment, one patient did not attend, two closed spontaneously, and one received ocriplasmin prior to the study start date. Only two patients with unilateral VMT received ocriplasmin and three underwent vitrectomy. Those failing to meet NICE criteria for unilateral VMT were predominantly asymptomatic (n=49) or had coexisting ERM (n=5) or both (n=2). Conclusion Ocriplasmin provides an alternative treatment for patients with symptomatic VMT. Our data shows that the majority of patients with VMT do not meet NICE TA297 primarily due to lack of symptoms. Those meeting NICE criteria, but not treated, tended to have coexisting macular pathology. Variation in patient selection due to subjective factors not outlined in NICE guidance suggests that real world outcomes of ocriplasmin therapy should be interpreted with caution. PMID:26834452

  19. Evaluation of Select Surface Processing Techniques for In Situ Application During the Additive Manufacturing Build Process

    NASA Astrophysics Data System (ADS)

    Book, Todd A.; Sangid, Michael D.

    2016-07-01

    Although additive manufacturing offers numerous performance advantages for different applications, it is not being used for critical applications due to uncertainties in structural integrity as a result of innate process variability and defects. To minimize uncertainty, the current approach relies on the concurrent utilization of process monitoring, post-processing, and non-destructive inspection in addition to an extensive material qualification process. This paper examines an alternative approach by evaluating the application of select surface process techniques, to include sliding severe plastic deformation (SPD) and fine particle shot peening, on direct metal laser sintering-produced AlSi10Mg materials. Each surface processing technique is compared to baseline as-built and post-processed samples as a proof of concept for surface enhancement. Initial results pairing sliding SPD with the manufacture's recommended thermal stress relief cycle demonstrated uniform recrystallization of the microstructure, resulting in a more homogeneous distribution of strain among the microstructure than as-built or post-processed conditions. This result demonstrates the potential for the in situ application of various surface processing techniques during the layerwise direct metal laser sintering build process.

  20. Evaluation of Select Surface Processing Techniques for In Situ Application During the Additive Manufacturing Build Process

    NASA Astrophysics Data System (ADS)

    Book, Todd A.; Sangid, Michael D.

    2016-03-01

    Although additive manufacturing offers numerous performance advantages for different applications, it is not being used for critical applications due to uncertainties in structural integrity as a result of innate process variability and defects. To minimize uncertainty, the current approach relies on the concurrent utilization of process monitoring, post-processing, and non-destructive inspection in addition to an extensive material qualification process. This paper examines an alternative approach by evaluating the application of select surface process techniques, to include sliding severe plastic deformation (SPD) and fine particle shot peening, on direct metal laser sintering-produced AlSi10Mg materials. Each surface processing technique is compared to baseline as-built and post-processed samples as a proof of concept for surface enhancement. Initial results pairing sliding SPD with the manufacture's recommended thermal stress relief cycle demonstrated uniform recrystallization of the microstructure, resulting in a more homogeneous distribution of strain among the microstructure than as-built or post-processed conditions. This result demonstrates the potential for the in situ application of various surface processing techniques during the layerwise direct metal laser sintering build process.

  1. Quality in Careers Guidance.

    ERIC Educational Resources Information Center

    Plant, Peter

    This paper examines quality issues in career guidance, counseling, and information services in Europe and elsewhere from a range of different perspectives related to economic, ethical, and/or effectiveness criteria. Selected examples from the European Union member states, Canada, and the United States are used to illustrate how quality is…

  2. Internet Guidance.

    ERIC Educational Resources Information Center

    Savage, Frank X.

    1999-01-01

    States that children need proper guidance and boundaries to reap the benefits of the Internet. Focuses on two issues: how parents can protect their children from the Internet's potential dangers and how they can help their children use the Internet to get work done. Includes suggestions for teachers to help parents meet these challenges. (VWC)

  3. GUIDANCE DOCUMENTS

    EPA Science Inventory

    Defn: Guidance Document - A peer-reviewed document stating overarching principles and practices to be followed (also includes handbook documents).

    Selective deposition of polycrystalline diamond films using photolithography with addition of nanodiamonds as nucleation centers

    NASA Astrophysics Data System (ADS)

    Okhotnikov, V. V.; Linnik, S. A.; Gaidaichuk, A. V.; Shashev, D. V.; Nazarova, G. Yu; Yurchenko, V. I.

    2016-02-01

    A new method of selective deposition of polycrystalline diamond has been developed and studied. The diamond coatings with a complex, predetermined geometry and resolution up to 5 μm were obtained. A high density of polycrystallites in the coating area was reached (up to 32·107 pcs/cm2). The uniformity of the film reached 100%, and the degree of the surface contamination by parasitic crystals did not exceed 2%. The technology was based on the application of the standard photolithography with an addition of nanodiamond suspension into the photoresist that provided the creation of the centers of further nucleation in the areas which require further overgrowth. The films were deposited onto monocrystalline silicon substrates using the method of “hot filaments” in the CVD reactor. The properties of the coating and the impact of the nanodiamond suspension concentration in the photoresist were also studied. The potential use of the given method includes a high resolution, technological efficiency, and low labor costs compared to the standard methods (laser treatment, chemical etching in aggressive environments,).

  4. Terminal Performance Objectives for Selected Programs in Business Education, Distributive Education, Work Experience Education, and Career Guidance.

    ERIC Educational Resources Information Center

    San Mateo Union High School District, CA.

    San Mateo Union High School District staff members participated in a workshop for the purpose of identifying the minimum Terminal Performance Objectives for selected programs. The objectives were written in detail to indicate (1) the student performance expected, (2) the conditions under which the student will perform, and (3) the extent to which…

  5. Rapid additive manufacturing of MR compatible multipinhole collimators with selective laser melting of tungsten powder

    SciTech Connect

    Deprez, Karel; Vandenberghe, Stefaan; Van Audenhaege, Karen; Van Vaerenbergh, Jonas; Van Holen, Roel

    2013-01-15

    Purpose: The construction of complex collimators with a high number of oblique pinholes is very labor intensive, expensive or is sometimes impossible with the current available techniques (drilling, milling or electric discharge machining). All these techniques are subtractive: one starts from solid plates and the material at the position of the pinholes is removed. The authors used a novel technique for collimator construction, called metal additive manufacturing. This process starts with a solid piece of tungsten on which a first layer of tungsten powder is melted. Each subsequent layer is then melted on the previous layer. This melting is done by selective laser melting at the locations where the CAD design file defines solid material. Methods: A complex collimator with 20 loftholes with 500 {mu}m diameter pinhole opening was designed and produced (16 mm thick and 70 Multiplication-Sign 52 mm{sup 2} transverse size). The density was determined, the production accuracy was measured (GOM ATOS II Triple Scan, Nikon AZ100M microscope, Olympus IMT200 microscope). Point source measurements were done by mounting the collimator on a SPECT detector. Because there is increasing interest in dual-modality SPECT-MR imaging, the collimator was also positioned in a 7T MRI scanner (Bruker Pharmascan). A uniform phantom was acquired using T1, T2, and T2* sequences to check for artifacts or distortion of the phantom images due to the collimator presence. Additionally, three tungsten sample pieces (250, 500, and 750 {mu}m thick) were produced. The density, attenuation (140 keV beam), and uniformity (GE eXplore Locus SP micro-CT) of these samples were measured. Results: The density of the collimator was equal to 17.31 {+-} 0.10 g/cm{sup 3} (89.92% of pure tungsten). The production accuracy ranges from -260 to +650 {mu}m. The aperture positions have a mean deviation of 5 {mu}m, the maximum deviation was 174 {mu}m and the minimum deviation was -122 {mu}m. The mean aperture diameter

  6. Real-Time Color-Doppler Guidance of HIFU for the Selective Avoidance or Occlusion of Blood Vessels

    NASA Astrophysics Data System (ADS)

    Rabkin, Brian A.; Zderic, Vesna; Vaezy, Shahram

    2005-03-01

    High-intensity focused ultrasound (HIFU) has been shown to effectively occlude blood vessels deep within tissue. The objective of the current study was to synchronize HIFU and color-Doppler ultrasound (US) for the real-time visualization of flow within blood vessels during HIFU treatment. The excitation of the HIFU was synchronized with the color-Doppler imager by collecting the excitation pulses of one of the elements of either a curved array intracavitary (C 9-5) or an intraoperative (CL 10-5) imaging probe. The collected excitation pulse was converted into a TTL-high pulse, which was delayed and gated to time the excitation duration and location of the HIFU pulse with respect to each imaging frame. The single pulse was used to drive a 3.2 MHz concave HIFU transducer (focal length of 3.5 cm, f-number 1) while the US imager was not collecting RF signals from the treatment region of the US image. The feasibility of the system was demonstrated in vivo by the selective ablation of tissue adjacent to, or the occlusion of, large vessels (including the femoral artery) both transcutaneously and interoperatively in the rabbit and pig. For the occlusion of vessels, the HIFU focus was placed immediately distal (with respect to the transducer) to the vessel at a depth of 2-2.5 cm. HIFU was applied at in situ intensities of 1000-2000 W/cm2, at a duty cycle of 50-75%, and a HIFU pulse repetition frequency (set by the US image frame rate) of 6-18 Hz. During each HIFU exposure, the HIFU pulse resulted in color interference bands running vertically within the color-Doppler window. Through the synchronization of the US imager with the HIFU excitation, the location and duration of the interference bands were set outside the treatment region within each image frame. This provided the operator with a clear view of the HIFU treatment site during therapy. Gross assessment showed necrosis of the tissue surrounding the HIFU treated vessel and occlusion of vessels up to 4 mm in diameter

  7. On the Additive and Dominant Variance and Covariance of Individuals Within the Genomic Selection Scope

    PubMed Central

    Vitezica, Zulma G.; Varona, Luis; Legarra, Andres

    2013-01-01

    Genomic evaluation models can fit additive and dominant SNP effects. Under quantitative genetics theory, additive or “breeding” values of individuals are generated by substitution effects, which involve both “biological” additive and dominant effects of the markers. Dominance deviations include only a portion of the biological dominant effects of the markers. Additive variance includes variation due to the additive and dominant effects of the markers. We describe a matrix of dominant genomic relationships across individuals, D, which is similar to the G matrix used in genomic best linear unbiased prediction. This matrix can be used in a mixed-model context for genomic evaluations or to estimate dominant and additive variances in the population. From the “genotypic” value of individuals, an alternative parameterization defines additive and dominance as the parts attributable to the additive and dominant effect of the markers. This approach underestimates the additive genetic variance and overestimates the dominance variance. Transforming the variances from one model into the other is trivial if the distribution of allelic frequencies is known. We illustrate these results with mouse data (four traits, 1884 mice, and 10,946 markers) and simulated data (2100 individuals and 10,000 markers). Variance components were estimated correctly in the model, considering breeding values and dominance deviations. For the model considering genotypic values, the inclusion of dominant effects biased the estimate of additive variance. Genomic models were more accurate for the estimation of variance components than their pedigree-based counterparts. PMID:24121775

  8. Testing for Additivity at Select Mixture Groups of Interest Based on Statistical Equivalence Testing Methods

    SciTech Connect

    Stork, LeAnna M.; Gennings, Chris; Carchman, Richard; Carter, Jr., Walter H.; Pounds, Joel G.; Mumtaz, Moiz

    2006-12-01

    Several assumptions, defined and undefined, are used in the toxicity assessment of chemical mixtures. In scientific practice mixture components in the low-dose region, particularly subthreshold doses, are often assumed to behave additively (i.e., zero interaction) based on heuristic arguments. This assumption has important implications in the practice of risk assessment, but has not been experimentally tested. We have developed methodology to test for additivity in the sense of Berenbaum (Advances in Cancer Research, 1981), based on the statistical equivalence testing literature where the null hypothesis of interaction is rejected for the alternative hypothesis of additivity when data support the claim. The implication of this approach is that conclusions of additivity are made with a false positive rate controlled by the experimenter. The claim of additivity is based on prespecified additivity margins, which are chosen using expert biological judgment such that small deviations from additivity, which are not considered to be biologically important, are not statistically significant. This approach is in contrast to the usual hypothesis-testing framework that assumes additivity in the null hypothesis and rejects when there is significant evidence of interaction. In this scenario, failure to reject may be due to lack of statistical power making the claim of additivity problematic. The proposed method is illustrated in a mixture of five organophosphorus pesticides that were experimentally evaluated alone and at relevant mixing ratios. Motor activity was assessed in adult male rats following acute exposure. Four low-dose mixture groups were evaluated. Evidence of additivity is found in three of the four low-dose mixture groups.The proposed method tests for additivity of the whole mixture and does not take into account subset interactions (e.g., synergistic, antagonistic) that may have occurred and cancelled each other out.

  9. Evolution of the additive genetic variance-covariance matrix under continuous directional selection on a complex behavioural phenotype.

    PubMed

    Careau, Vincent; Wolak, Matthew E; Carter, Patrick A; Garland, Theodore

    2015-11-22

    Given the pace at which human-induced environmental changes occur, a pressing challenge is to determine the speed with which selection can drive evolutionary change. A key determinant of adaptive response to multivariate phenotypic selection is the additive genetic variance-covariance matrix ( G: ). Yet knowledge of G: in a population experiencing new or altered selection is not sufficient to predict selection response because G: itself evolves in ways that are poorly understood. We experimentally evaluated changes in G: when closely related behavioural traits experience continuous directional selection. We applied the genetic covariance tensor approach to a large dataset (n = 17 328 individuals) from a replicated, 31-generation artificial selection experiment that bred mice for voluntary wheel running on days 5 and 6 of a 6-day test. Selection on this subset of G: induced proportional changes across the matrix for all 6 days of running behaviour within the first four generations. The changes in G: induced by selection resulted in a fourfold slower-than-predicted rate of response to selection. Thus, selection exacerbated constraints within G: and limited future adaptive response, a phenomenon that could have profound consequences for populations facing rapid environmental change. PMID:26582016

  10. 34 CFR 387.30 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... under this program? In addition to the criteria in 34 CFR 385.31(c), the Secretary uses the following... program; (iii) There is evidence of educationally focused practicum or other field experiences in...

  11. 34 CFR 387.30 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... under this program? In addition to the criteria in 34 CFR 385.31(c), the Secretary uses the following... program; (iii) There is evidence of educationally focused practicum or other field experiences in...

  12. 34 CFR 387.30 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... under this program? In addition to the criteria in 34 CFR 385.31(c), the Secretary uses the following... program; (iii) There is evidence of educationally focused practicum or other field experiences in...

  13. 34 CFR 387.30 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... under this program? In addition to the criteria in 34 CFR 385.31(c), the Secretary uses the following... program; (iii) There is evidence of educationally focused practicum or other field experiences in...

  14. 34 CFR 387.30 - What additional selection criteria are used under this program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... under this program? In addition to the criteria in 34 CFR 385.31(c), the Secretary uses the following... program; (iii) There is evidence of educationally focused practicum or other field experiences in...

  15. 34 CFR 389.30 - What additional selection criterion is used under this program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... criterion is used under this program? In addition to the criteria in 34 CFR 385.31(c), the Secretary uses... improve the competence of professional and other personnel in the rehabilitation agencies...

  16. 34 CFR 389.30 - What additional selection criterion is used under this program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... criterion is used under this program? In addition to the criteria in 34 CFR 385.31(c), the Secretary uses... improve the competence of professional and other personnel in the rehabilitation agencies...

  17. External Standards or Standard Additions? Selecting and Validating a Method of Standardization.

    ERIC Educational Resources Information Center

    Harvey, David

    2002-01-01

    Reports an experiment which is suitable for an introductory course in analytical chemistry and which illustrates the importance of matrix effects when selecting a method of standardization. Asserts that students learn how a spike recovery is used to validate an analytical method, and obtain practical experience in the difference between performing…

  18. Breeding site selection by coho salmon (Oncorhynchus kisutch) in relation to large wood additions and factors that influence reproductive success

    USGS Publications Warehouse

    Clark, Steven M.; Dunham, Jason B.; McEnroe, Jeffery R.; Lightcap, Scott W.

    2014-01-01

    The fitness of female Pacific salmon (Oncorhynchus spp.) with respect to breeding behavior can be partitioned into at least four fitness components: survival to reproduction, competition for breeding sites, success of egg incubation, and suitability of the local environment near breeding sites for early rearing of juveniles. We evaluated the relative influences of habitat features linked to these fitness components with respect to selection of breeding sites by coho salmon (Oncorhynchus kisutch). We also evaluated associations between breeding site selection and additions of large wood, as the latter were introduced into the study system as a means of restoring habitat conditions to benefit coho salmon. We used a model selection approach to organize specific habitat features into groupings reflecting fitness components and influences of large wood. Results of this work suggest that female coho salmon likely select breeding sites based on a wide range of habitat features linked to all four hypothesized fitness components. More specifically, model parameter estimates indicated that breeding site selection was most strongly influenced by proximity to pool-tail crests and deeper water (mean and maximum depths). Linkages between large wood and breeding site selection were less clear. Overall, our findings suggest that breeding site selection by coho salmon is influenced by a suite of fitness components in addition to the egg incubation environment, which has been the emphasis of much work in the past.

  19. Selection for increased desiccation resistance in Drosophila melanogaster: Additive genetic control and correlated responses for other stresses

    SciTech Connect

    Hoffmann, A.A.; Parsons, P.A. )

    1989-08-01

    Previously we found that Drosophila melanogaster lines selected for increased desiccation resistance have lowered metabolic rate and behavioral activity levels, and show correlated responses for resistance to starvation and a toxic ethanol level. These results were consistent with a prediction that increased resistance to many environmental stresses may be genetically correlated because of a reduction in metabolic energy expenditure. Here we present experiments on the genetic basis of the selection response and extend the study of correlated responses to other stresses. The response to selection was not sex-specific and involved X-linked and autosomal genes acting additively. Activity differences contributed little to differences in desiccation resistance between selected and control lines. Selected lines had lower metabolic rates than controls in darkness when activity was inhibited. Adults from selected lines showed increased resistance to a heat shock, {sup 60}Co-gamma-radiation, and acute ethanol and acetic acid stress. The desiccation, ethanol and starvation resistance of isofemale lines set up from the F2s of a cross between one of the selected and one of the control lines were correlated. Selected and control lines did not differ in ether-extractable lipid content or in resistance to acetone, ether or a cold shock.

    1. Processing of noisy magnetotelluric data using digital filters and additional data selection criteria

      NASA Astrophysics Data System (ADS)

      Fontes, S. L.; Harinarayana, T.; Dawes, G. J. K.; Hutton, V. R. S.

      1988-10-01

      Although the magnetotelluric (MT) method is known to be effective and fast in probing the electrical conductivity structure of the Earth at crustal depths, the results are often degraded by industrial and cultural noise. To obtain reliable processed results for modelling, it is first necessary to extract or select the natural signals from the contaminated time series. Various noise-reduction techniques based on digital filters are discussed with special reference to persistent noise signals, e.g. from power lines, DC-operated railways and electrical fences. Both previously suggested techniques (delay-line and notch filtering) and two other procedures (maximum entropy extension and deconvolution filtering) are applied to both synthetic data and to field observations from southern Scotland and the Italian Alps. Better quality data sets and more geophysically acceptable Earth models are shown to result. Noise of a more intermittent nature has recently been observed in MT observations near the development site of the geothermal power station on Milos, Greece. Large highly coherent electromagnetic field signals were observed to coincide with the opening and closure of the valves on the test wells. In this case, meaningful apparent resistivity curves could be obtained from an undisturbed subset of the previously accepted data, which had been selected mainly on the basis of signal power. Delay-line filtering is shown to be superior to notch filtering in eliminating non-sinusoidal noise, while both the MEM extension and the window deconvolution techniques are found to be useful in spike removal. These studies illustrate that use of an automatic data selection procedure should only be undertaken with great care in areas where the cultural noise is high. In such cases, continuous time-domain monitoring of the MT signals is recommended. The appropriate techniques of noise reduction can then be applied.

    2. 34 CFR 350.55 - What are the additional considerations for selecting Field-Initiated Project applications for...

      Code of Federal Regulations, 2014 CFR

      2014-07-01

      ... 34 Education 2 2014-07-01 2013-07-01 true What are the additional considerations for selecting Field-Initiated Project applications for funding? 350.55 Section 350.55 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION DISABILITY...

    3. 34 CFR 660.33 - What additional selection criteria does the Secretary use for an application to develop...

      Code of Federal Regulations, 2010 CFR

      2010-07-01

      ..., DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM How Does the Secretary Make a Grant... 34 Education 3 2010-07-01 2010-07-01 false What additional selection criteria does the Secretary use for an application to develop specialized instructional materials? 660.33 Section 660.33...

    4. Hyperactivity--Drug Therapy/Food Additives/Allergies. A Selective Bibliography. Exceptional Child Bibliography Series No. 602.

      ERIC Educational Resources Information Center

      ERIC Clearinghouse on Handicapped and Gifted Children, Reston, VA.

      The annotated bibliography on Hyperactivity--Drug Therapy/Food Additives/Allergies contains approximately 65 abstracts and associated indexing information for documents or journal articles published from 1968 to 1975 and selected from the computer files of the Council for Exceptional Children's Information Services and the Education Resources…

    5. 36 CFR 1236.28 - What additional requirements apply to the selection and maintenance of electronic records storage...

      Code of Federal Regulations, 2011 CFR

      2011-07-01

      ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false What additional requirements apply to the selection and maintenance of electronic records storage media for permanent records? 1236.28 Section 1236.28 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT ELECTRONIC...

    6. Additive Manufacturing by selective laser melting the realizer desktop machine and its application for the dental industry

      NASA Astrophysics Data System (ADS)

      Gebhardt, Andreas; Schmidt, Frank-Michael; Hötter, Jan-Steffen; Sokalla, Wolfgang; Sokalla, Patrick

      Additive Manufacturing of metal parts by Selective Laser Melting has become a powerful tool for the direct manufacturing of complex parts mainly for the aerospace and medical industry. With the introduction of its desktop machine, Realizer targeted the dental market. The contribution describes the special features of the machine, discusses details of the process and shows manufacturing results focused on metal dental devices.

    7. 34 CFR 660.33 - What additional selection criteria does the Secretary use for an application to develop...

      Code of Federal Regulations, 2011 CFR

      2011-07-01

      ... use for an application to develop specialized instructional materials? 660.33 Section 660.33 Education...? § 660.33 What additional selection criteria does the Secretary use for an application to develop... evaluates an application to develop specialized instructional materials on the basis of the criteria in...

    8. 34 CFR 611.12 - What additional selection criteria are used for an application proposing teacher recruitment...

      Code of Federal Regulations, 2011 CFR

      2011-07-01

      ... application proposing teacher recruitment activities? 611.12 Section 611.12 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM State Grants Program § 611.12 What additional selection criteria are used for an application proposing teacher recruitment activities? In reviewing...

    9. 34 CFR 611.22 - What additional selection criteria are used for a pre-application that proposes teacher...

      Code of Federal Regulations, 2010 CFR

      2010-07-01

      ...-application that proposes teacher recruitment activities? 611.22 Section 611.22 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.22 What additional selection criteria are used for a pre-application that proposes teacher recruitment activities? In...

    10. 34 CFR 611.12 - What additional selection criteria are used for an application proposing teacher recruitment...

      Code of Federal Regulations, 2010 CFR

      2010-07-01

      ... application proposing teacher recruitment activities? 611.12 Section 611.12 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM State Grants Program § 611.12 What additional selection criteria are used for an application proposing teacher recruitment activities? In reviewing...

    11. 34 CFR 611.22 - What additional selection criteria are used for a pre-application that proposes teacher...

      Code of Federal Regulations, 2011 CFR

      2011-07-01

      ...-application that proposes teacher recruitment activities? 611.22 Section 611.22 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.22 What additional selection criteria are used for a pre-application that proposes teacher recruitment activities? In...

    12. 34 CFR 611.24 - What additional selection criteria are used for a full application that proposes teacher...

      Code of Federal Regulations, 2010 CFR

      2010-07-01

      ... application that proposes teacher recruitment activities? 611.24 Section 611.24 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.24 What additional selection criteria are used for a full application that proposes teacher recruitment activities?...

    13. 34 CFR 611.24 - What additional selection criteria are used for a full application that proposes teacher...

      Code of Federal Regulations, 2011 CFR

      2011-07-01

      ... application that proposes teacher recruitment activities? 611.24 Section 611.24 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.24 What additional selection criteria are used for a full application that proposes teacher recruitment activities?...

    14. 34 CFR 611.22 - What additional selection criteria are used for a pre-application that proposes teacher...

      Code of Federal Regulations, 2014 CFR

      2014-07-01

      ...-application that proposes teacher recruitment activities? 611.22 Section 611.22 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.22 What additional selection criteria are used for a pre-application that proposes teacher recruitment activities? In...

    15. 34 CFR 611.24 - What additional selection criteria are used for a full application that proposes teacher...

      Code of Federal Regulations, 2014 CFR

      2014-07-01

      ... application that proposes teacher recruitment activities? 611.24 Section 611.24 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.24 What additional selection criteria are used for a full application that proposes teacher recruitment activities?...

    16. 34 CFR 611.12 - What additional selection criteria are used for an application proposing teacher recruitment...

      Code of Federal Regulations, 2014 CFR

      2014-07-01

      ... application proposing teacher recruitment activities? 611.12 Section 611.12 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM State Grants Program § 611.12 What additional selection criteria are used for an application proposing teacher recruitment activities? In reviewing...

    17. 34 CFR 611.22 - What additional selection criteria are used for a pre-application that proposes teacher...

      Code of Federal Regulations, 2013 CFR

      2013-07-01

      ...-application that proposes teacher recruitment activities? 611.22 Section 611.22 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.22 What additional selection criteria are used for a pre-application that proposes teacher recruitment activities? In...

    18. 34 CFR 611.24 - What additional selection criteria are used for a full application that proposes teacher...

      Code of Federal Regulations, 2012 CFR

      2012-07-01

      ... application that proposes teacher recruitment activities? 611.24 Section 611.24 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.24 What additional selection criteria are used for a full application that proposes teacher recruitment activities?...

    19. 34 CFR 611.12 - What additional selection criteria are used for an application proposing teacher recruitment...

      Code of Federal Regulations, 2013 CFR

      2013-07-01

      ... application proposing teacher recruitment activities? 611.12 Section 611.12 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM State Grants Program § 611.12 What additional selection criteria are used for an application proposing teacher recruitment activities? In reviewing...

    20. 34 CFR 611.22 - What additional selection criteria are used for a pre-application that proposes teacher...

      Code of Federal Regulations, 2012 CFR

      2012-07-01

      ...-application that proposes teacher recruitment activities? 611.22 Section 611.22 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.22 What additional selection criteria are used for a pre-application that proposes teacher recruitment activities? In...

    1. 34 CFR 611.24 - What additional selection criteria are used for a full application that proposes teacher...

      Code of Federal Regulations, 2013 CFR

      2013-07-01

      ... application that proposes teacher recruitment activities? 611.24 Section 611.24 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM Partnership Grants Program § 611.24 What additional selection criteria are used for a full application that proposes teacher recruitment activities?...

    2. 34 CFR 611.12 - What additional selection criteria are used for an application proposing teacher recruitment...

      Code of Federal Regulations, 2012 CFR

      2012-07-01

      ... application proposing teacher recruitment activities? 611.12 Section 611.12 Education Regulations of the... EDUCATION TEACHER QUALITY ENHANCEMENT GRANTS PROGRAM State Grants Program § 611.12 What additional selection criteria are used for an application proposing teacher recruitment activities? In reviewing...

    3. Selectivity in the Addition Reactions of Organometallic Reagents to Aziridine-2-carboxaldehydes: The Effects of Protecting Groups and Substitution Patterns

      PubMed Central

      Kulshrestha, Aman; Schomaker, Jennifer M.; Holmes, Daniel; Staples, Richard J.; Jackson, James E.; Borhan, Babak

      2014-01-01

      Good to excellent stereo-selectivity has been found in the addition reactions of Grignard and organo-zinc reagents to N-protected aziridine-2-carboxaldehydes. Specifically, high syn selectivity was obtained with benzyl-protected cis, tert-butyloxycar-bonyl-protected trans, and tosyl-pro-tected 2,3-disubstituted aziridine-2-car-boxaldehydes. Furthermore, rate and selectivity effects of ring substituents, temperature, solvent, and Lewis acid and base modifiers were studied. The diastereomeric preference of addition is dominated by the substrate aziri-dines’ substitution pattern and especially the electronic character and conformational preferences of the nitrogen protecting groups. To help rationalize the observed stereochemical outcomes, conformational and electronic structural analyses of a series of model systems representing the various substitution patterns have been explored by density functional calculations at the B3LYP/6–31G* level of theory with the SM8 solvation model to account for solvent effects. PMID:21928447

    4. Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions

      PubMed Central

      Im, G-Yoon J.; Bronner, Sarah M.; Goetz, Adam E.; Paton, Robert S.; Cheong, Paul H.-Y.; Houk, K. N.; Garg, Neil K.

      2010-01-01

      Efficient syntheses of 4,5-, 5,6-, and 6,7-indolyne precursors beginning from commercially available hydroxyindole derivatives are reported. The synthetic routes are versatile and allow access to indolyne precursors that remain unsubstituted on the pyrrole ring. Indolynes can be generated under mild fluoride-mediated conditions, trapped by a variety of nucleophilic reagents, and used to access a number of novel substituted indoles. Nucleophilic addition reactions to indolynes proceed with varying degrees of regioselectivity; distortion energies control regioselectivity and provide a simple model to predict the regioselectivity in the nucleophilic additions to indolynes and other unsymmetrical arynes. This model has led to the design of a substituted 4,5-indolyne that exhibits enhanced nucleophilic regioselectivity. PMID:21114321

    5. Site-selective DNA hydrolysis by Ce(IV)-EDTA with the use of one oligonucleotide additive bearing two monophosphates.

      PubMed

      Chen, Wen; Komiyama, Makoto

      2005-10-01

      Two deoxyuridine derivatives each bearing a monophosphate group at the 5-position with a C3 linker, were incorporated into an oligonucleotide. By using this modified oligonucleotide, a bulge was formed at a predetermined position in a DNA substrate, and two monophosphate groups were placed at both junctions of the bulge. Upon treatment of the mixture with Ce(IV)-EDTA at pH 7.0, the phosphodiester linkages at the bulge site were selectively and efficiently hydrolyzed. The monophosphate groups introduced into the bulge site greatly accelerated site-selective DNA scission. Compared with the previously reported two-additive system, which combines two oligonucleotide additives each with a monophosphate at their termini, the present one-additive system is simpler and more convenient. Furthermore, site-selective DNA hydrolysis by using this one-additive system is successful even at high reaction temperatures (e.g., 55 degrees C). This reflects the thermodynamic stability of the duplexes formed between the substrate and the additive DNA. PMID:16196014

    6. Uprated fine guidance sensor study

      NASA Technical Reports Server (NTRS)

      1984-01-01

      Future orbital observatories will require star trackers of extremely high precision. These sensors must maintain high pointing accuracy and pointing stability simultaneously with a low light level signal from a guide star. To establish the fine guidance sensing requirements and to evaluate candidate fine guidance sensing concepts, the Space Telescope Optical Telescope Assembly was used as the reference optical system. The requirements review was separated into three areas: Optical Telescope Assembly (OTA), Fine Guidance Sensing and astrometry. The results show that the detectors should be installed directly onto the focal surface presented by the optics. This would maximize throughput and minimize point stability error by not incoporating any additional optical elements.

    7. Surface-imprinted magnetic particles for highly selective sulfonamides recognition prepared by reversible addition fragmentation chain transfer polymerization.

      PubMed

      Xie, Xiaoyu; Liu, Xia; Pan, Xiaoyan; Chen, Liang; Wang, Sicen

      2016-01-01

      In this work, novel magnetic molecularly imprinted polymers (MMIPs) were prepared by reversible addition fragmentation chain transfer (RAFT) polymerization using sulfamerazine as the template. With the controlled/living property of RAFT polymerization, the resulting MMIPs showed high selectivity for sulfonamides recognition. The MMIPs were characterized by transmission electron microscopy, Fourier transform infrared, vibrating sample magnetometer, X-ray diffraction, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The static and selectivity binding experiments demonstrated the desirable adsorption capacity and high selectivity of the MMIPs. The developed MMIPs were used as the solid-phase extraction sorbents to selectively extract four sulfonamides from aqueous solution. The recoveries of the spiked pond water ranged from 61.2 to 94.1% with RSD lower than 6.5%. This work demonstrated a versatile approach for the preparation of well-constructed MMIPs for application in the field of solid-phase extraction. PMID:26637219

    8. Selectivity of molybdenum catalyst in hydrodesulfurization, hydrodenitrogenation, and hydrodeoxygenation: effect of additives on dibenzothiophene hydrodesulfurization

      SciTech Connect

      Nagai, M.; Kabe, T.

      1983-06-01

      Kinetic studies of the hydrodesulfurization of dibenzothiophene on a presulfided molybdena-alumina catalyst were carried out in a high-pressure-flow microreactor. The mechanism discussed is based on selective poisoning studies, using various nitrogen, polyaromatic, sulfur, and oxygen compounds. The nitrogen compounds inhibited the hydrogenation of dibenzothiophene because they adsorbed more strongly than did dibenzothiophene at lower temperatures. At higher temperatures, the nitrogen compounds also hinder the desulfurization together with the hydrogenation of dibenzothiophene. The sulfur and the oxygen compounds retarded all reactions of the desulfurization of dibenzothiophene. The reactions of the desulfurization, the denitrogenation, and the deoxygenation proceed on one type of site and the hydrogenation reactions on another site. 10 figures.

    9. Activation and stabilization of the hydroperoxide lyase enzymatic extract from mint leaves (Mentha spicata) using selected chemical additives.

      PubMed

      Akacha, Najla B; Karboune, Salwa; Gargouri, Mohamed; Kermasha, Selim

      2010-03-01

      The effects of selected lyoprotecting excipients and chemical additives on the specific activity and the thermal stability of the hydroperoxide lyase (HPL) enzymatic extract from mint leaves were investigated. The addition of KCl (5%, w/w) and dextran (2.5%, w/w) to the enzymatic extract, prior to lyophilization, increased the HPL specific activity by 2.0- and 1.2-fold, respectively, compared to the control lyophilized extract. From half-life time (t (1/2)), it can be seen that KCl has enhanced the HPL stability by 1.3- to 2.3-fold, during long-period storage at -20 degrees Celsius and 4 degrees Celsius. Among the selected additives used throughout this study, glycine appeared to be the most effective one. In addition to the activation effect conferred by glycine, it also enhanced the HPL thermal stability. In contrast, polyhydroxyl-containing additives were not effective for stabilizing the HPL enzymatic extract. On the other hand, there was no signification increase in HPL activity and its thermal stability with the presence of Triton X-100. The results also showed that in the presence of glycine (10%), the catalytic efficiency of HPL was increased by 2.45-fold than that without additive. PMID:19430937

    10. Rheological and sensory behaviour of rice flour dough: effect of selected additives in relation to dough flattening.

      PubMed

      Dixit, Yash; Bhattacharya, Suvendu

      2015-08-01

      The handling of rice flour doughs in terms of sheeting, flattening and rolling is difficult due to the absence of gluten forming proteins; scope exists to improve these characteristics by incorporating appropriate additives during the preparation of rice doughs. Different levels of additives such as whey protein concentrate (WPC) (0-10 %), xanthan gum (0-5 %), sucrose (0-20 %) and salt (0-2 %) have been incorporated, and the rheological (small-deformation oscillation) as well as sensory characteristics have been determined, in addition to microstructural observations and finding inter-relationships. The second order polynomial can adequately explain the rheological parameters like storage modulus, loss modulus and complex viscosity (R = 0.863-0.889, p ≤ 0.01) while it is poor for phase angle (R = 0.659, p ≤ 0.01). Among these additives, xanthan gum imparts the strongest effect (significant at p ≤ 0.01) followed by whey protein concentrate. The effects of these additives are predominantly linear though quadratic effects are also significant in several cases. A cohesive microstructure with improved binding occurs with a high level (7.5 %) of WPC. It is concluded that a judicious selection of additives in appropriate levels can develop rice doughs that possess the desirable handling properties leading to preparation of products. PMID:26243905

    11. GUIDANCE CURRICULUM FOR INCREASED SELF-UNDERSTANDING AND MOTIVATION FOR CAREER PLANNING. PLANNING AND DEVELOPMENT OF RESEARCH PROGRAMS IN SELECTED AREAS OF VOCATIONAL EDUCATION, VOLUME III, APPENDIX.

      ERIC Educational Resources Information Center

      SHERMAN, VIVIAN S.

      EXPERIMENTAL MATERIALS THAT WERE DEVELOPED FOR THE VOCATIONAL GUIDANCE OF JUNIOR HIGH SCHOOL STUDENTS WERE PRESENTED IN THIS APPENDIX TO ED 010 625. THESE MATERIALS WERE PLANNED TO ENABLE STUDENTS TO THOROUGHLY AND SYSTEMATICALLY EXPLORE THEIR OWN SELF-PERCEPTIONS, ATTITUDES, PERSONAL VALUES, ACHIEVEMENT, ABILITIES, AND DIVERSE CAREER…

    12. Design of Selective Gas Sensors Using Additive-Loaded In2O3 Hollow Spheres Prepared by Combinatorial Hydrothermal Reactions

      PubMed Central

      Kim, Sun-Jung; Hwang, In-Sung; Kang, Yun Chan; Lee, Jong-Heun

      2011-01-01

      A combinatorial hydrothermal reaction has been used to prepare pure and additive (Sb, Cu, Nb, Pd, and Ni)-loaded In2O3 hollow spheres for gas sensor applications. The operation of Pd- and Cu-loaded In2O3 sensors at 371 °C leads to selective H2S detection. Selective detection of CO and NH3 was achieved by the Ni-In2O3 sensor at sensing temperatures of 371 and 440 °C, respectively. The gas responses of six different sensors to NH3, H2S, H2, CO and CH4 produced unique gas sensing patterns that can be used for the artificial recognition of these gases. PMID:22346661

    13. Theater As A Guidance Technique

      ERIC Educational Resources Information Center

      Wolpert, William

      1973-01-01

      Guidance-drama activity provides (a) crisp definitions of selected issues; (b) potent modeling from the characters in the play, the students actively engaged in the play, and the students involved in the discussions that follow the play; and (c) a technique for peer-led discussions on sensitive issues. This article gives precise definition to the…

    14. Highly E-Selective and Enantioselective Michael Addition to Electron-Deficient Internal Alkynes Under Chiral Iminophosphorane Catalysis.

      PubMed

      Uraguchi, Daisuke; Yamada, Kohei; Ooi, Takashi

      2015-08-17

      A highly E-selective and enantioselective conjugate addition of 2-benzyloxythiazol-5(4H)-ones to β-substituted alkynyl N-acyl pyrazoles is achieved under the catalysis of a P-spiro chiral iminophosphorane. Simultaneous control of the newly generated central chirality and olefin geometry is possible with a wide array of the alkynyl Michael acceptors possessing different aromatic and aliphatic β-substituents, as well as the various α-amino acid-derived thiazolone nucleophiles. This protocol provides access to structurally diverse, optically active α-amino acids bearing a geometrically defined trisubstituted olefinic component at the α-position. PMID:26138611

    15. Asymmetric Iridium-Catalyzed C-C Coupling of Chiral Diols via Site-Selective Redox-Triggered Carbonyl Addition.

      PubMed

      Shin, Inji; Krische, Michael J

      2016-01-01

      Cyclometalated π-allyliridium C,O-benzoate complexes modified by axially chiral chelating phosphine ligands display a pronounced kinetic preference for primary alcohol dehydrogenation, enabling highly site-selective redox-triggered carbonyl additions of chiral primary-secondary 1,3-diols with exceptional levels of catalyst-directed diastereoselectivity. Unlike conventional methods for carbonyl allylation, the present redox-triggered alcohol C-H functionalizations bypass the use of protecting groups, premetalated reagents, and discrete alcohol-to-aldehyde redox reactions. PMID:26187028

    16. A review on powder-based additive manufacturing for tissue engineering: selective laser sintering and inkjet 3D printing

      NASA Astrophysics Data System (ADS)

      Farid Seyed Shirazi, Seyed; Gharehkhani, Samira; Mehrali, Mehdi; Yarmand, Hooman; Metselaar, Hendrik Simon Cornelis; Adib Kadri, Nahrizul; Azuan Abu Osman, Noor

      2015-06-01

      Since most starting materials for tissue engineering are in powder form, using powder-based additive manufacturing methods is attractive and practical. The principal point of employing additive manufacturing (AM) systems is to fabricate parts with arbitrary geometrical complexity with relatively minimal tooling cost and time. Selective laser sintering (SLS) and inkjet 3D printing (3DP) are two powerful and versatile AM techniques which are applicable to powder-based material systems. Hence, the latest state of knowledge available on the use of AM powder-based techniques in tissue engineering and their effect on mechanical and biological properties of fabricated tissues and scaffolds must be updated. Determining the effective setup of parameters, developing improved biocompatible/bioactive materials, and improving the mechanical/biological properties of laser sintered and 3D printed tissues are the three main concerns which have been investigated in this article.

    17. Many QTLs with minor additive effects are associated with a large difference in growth between two selection lines in chickens.

      PubMed

      Jacobsson, Lina; Park, Hee-Bok; Wahlberg, Per; Fredriksson, Robert; Perez-Enciso, Miguel; Siegel, Paul B; Andersson, Leif

      2005-10-01

      Two growth-selected lines in chickens have been developed from a single founder population by divergent selection for body weight at 56 days of age. After more than 40 generations of selection they show a nine-fold difference in body weight at selection age and large differences in growth rate, appetite, fat deposition and metabolic characteristics. We have generated a large intercross between these lines comprising more than 800 F2 birds. QTL mapping revealed 13 loci affecting growth. The most striking observation was that the allele in the high weight line in all cases was associated with enhanced growth, but each locus explained only a small proportion of the phenotypic variance using a standard QTL model (1.3-3.1%). This result is in sharp contrast to our previous study where we reported that the two-fold difference in adult body size between the red junglefowl and White Leghorn domestic chickens is explained by a small number of QTLs with large additive effects. Furthermore, no QTLs for anorexia or antibody response were detected despite large differences for these traits between the founder lines. The result is an excellent example where a large phenotypic difference between populations occurs in the apparent absence of any single locus with large phenotypic effects. The study underscores the need for powerful experimental designs in genetic studies of multifactorial traits. No QTL at all would have reached genome-wide significance using a less powerful design (e.g. approx. 200 F2 individuals) regardless of the nine-fold phenotypic difference between the founder lines for the selected trait. PMID:16356285

    18. Engineering the donor selectivity of D-fructose-6-phosphate aldolase for biocatalytic asymmetric cross-aldol additions of glycolaldehyde.

      PubMed

      Szekrenyi, Anna; Soler, Anna; Garrabou, Xavier; Guérard-Hélaine, Christine; Parella, Teodor; Joglar, Jesús; Lemaire, Marielle; Bujons, Jordi; Clapés, Pere

      2014-09-22

      D-Fructose-6-phosphate aldolase (FSA) is a unique catalyst for asymmetric cross-aldol additions of glycolaldehyde. A combination of a structure-guided approach of saturation mutagenesis, site-directed mutagenesis, and computational modeling was applied to construct a set of FSA variants that improved the catalytic efficiency towards glycolaldehyde dimerization up to 1800-fold. A combination of mutations in positions L107, A129, and A165 provided a toolbox of FSA variants that expand the synthetic possibilities towards the preparation of aldose-like carbohydrate compounds. The new FSA variants were applied as highly efficient catalysts for cross-aldol additions of glycolaldehyde to N-carbobenzyloxyaminoaldehydes to furnish between 80-98 % aldol adduct under optimized reaction conditions. Donor competition experiments showed high selectivity for glycolaldehyde relative to dihydroxyacetone or hydroxyacetone. These results demonstrate the exceptional malleability of the active site in FSA, which can be remodeled to accept a wide spectrum of donor and acceptor substrates with high efficiency and selectivity. PMID:25146467

    19. Effect of Powder Reuse Times on Additive Manufacturing of Ti-6Al-4V by Selective Electron Beam Melting

      NASA Astrophysics Data System (ADS)

      Tang, H. P.; Qian, M.; Liu, N.; Zhang, X. Z.; Yang, G. Y.; Wang, J.

      2015-03-01

      An advantage of the powder-bed-based metal additive manufacturing (AM) processes is that the powder can be reused. The powder reuse or recycling times directly affect the affordability of the additively manufactured parts, especially for the AM of titanium parts. This study examines the influence of powder reuse times on the characteristics of Ti-6Al-4V powder, including powder composition, particle size distribution (PSD), apparent density, tap density, flowability, and particle morphology. In addition, tensile samples were manufactured and evaluated with respect to powder reuse times and sample locations in the powder bed. The following findings were made from reusing the same batch of powder 21 times for AM by selective electron beam melting: (i) the oxygen (O) content increased progressively with increasing reuse times but both the Al content and the V content remained generally stable (a small decrease only); (ii) the powder became less spherical with increasing reuse times and some particles showed noticeable distortion and rough surfaces after being reused 16 times; (iii) the PSD became narrower and few satellite particles were observed after 11 times of reuse; (iv) reused powder showed improved flowability; and (v) reused powder showed no measurable undesired influence on the AM process and the samples exhibited highly consistent tensile properties, irrespective of their locations in the powder bed. The implications of these findings were discussed.

    20. Addition of a hypoxic cell selective cytotoxic agent (mitomycin C or porfiromycin) to Fluosol-DA/carbogen/radiation.

      PubMed

      Holden, S A; Herman, T S; Teicher, B A

      1990-05-01

      In an effort to develop effective combination treatments for use with radiation against solid tumors, the cytotoxic effects of the addition of mitomycin C or porfiromycin on treatment with Fluosol-DA/carbogen (95% O2/5% CO2) breathing and radiation in the FSaIIC tumor system were studied. In vitro mitomycin C and porfiromycin were both preferentially cytotoxic toward hypoxic FSaIIC cells. After in vivo exposure, however, the cytotoxicity of mitomycin C toward single cell tumor suspensions obtained from whole tumors was exponential over the dose range studied, but for porfiromycin a plateau in cell killing was observed. With Fluosol-DA/carbogen breathing and single dose radiation, addition of either mitomycin C or porfiromycin increased the tumor cell kill achieved at 5 Gy by approximately 1.2 and 1.0 logs, respectively. Less effect was seen with addition of the drugs at the 10 and 15 Gy radiation doses. In tumor growth delay experiments, the addition of either mitomycin C or porfiromycin to Fluosol-DA/carbogen breathing and radiation resulted in primarily an additive increase in tumor growth delay. The survival of Hoechst 33342 dye-selected tumor cell subpopulations indicated that Fluosol-DA/carbogen breathing increased the cytotoxicity of radiation (10 Gy) more in the bright cell subpopulation (4-fold) than in the dim cell subpopulation (2-fold) resulting in an overall 4-fold sparing of the dim subpopulation. Mitomycin C and porfiromycin were both more toxic toward the dim cell subpopulations. Addition of mitomycin C or porfiromycin to Fluosol-DA/carbogen breathing and radiation (10 Gy) resulted in a primarily additive effect of the drugs and radiation killing in both tumor cell subpopulations. Thus, with mitomycin C/Fluosol-DA/carbogen and radiation there was a 2-fold sparing of dim cells and with porfiromycin in the combined treatment a 1.6-fold sparing of the dim cell population. Our results indicate that treatment strategies directed against both oxic and

    1. Elementary School Guidance Bibliography.

      ERIC Educational Resources Information Center

      Biasco, Frank

      This bibliography lists articles and books dealing with elementary school guidance. The bibliography is arranged alphabetically by author. No annotations are given. Approximately 70 titles are given, covering most phases of elementary guidance. (KJ)

    2. Collective cell migration: guidance principles and hierarchies.

      PubMed

      Haeger, Anna; Wolf, Katarina; Zegers, Mirjam M; Friedl, Peter

      2015-09-01

      Collective cell migration results from the establishment and maintenance of collective polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell migration depends on a reciprocal process between cell-intrinsic multicellular organization with leader-follower cell behavior and results in mechanosensory integration of extracellular guidance cues. Important guidance mechanisms include chemotaxis, haptotaxis, durotaxis, and strain-induced mechanosensing to move cell groups along interfaces and paths of least resistance. Additional guidance mechanisms steering cell groups during specialized conditions comprise electrotaxis and passive drift. To form higher-order cell and tissue structures during morphogenesis and cancer invasion, these guidance principles act in parallel and are integrated for collective adaptation to and shaping of varying tissue environments. We review mechanochemical and electrical inputs and multiparameter signal integration underlying collective guidance, decision making, and outcome. PMID:26137890

    3. Unified powered flight guidance

      NASA Technical Reports Server (NTRS)

      Brand, T. J.; Brown, D. W.; Higgins, J. P.

      1973-01-01

      A complete revision of the orbiter powered flight guidance scheme is presented. A unified approach to powered flight guidance was taken to accommodate all phases of exo-atmospheric orbiter powered flight, from ascent through deorbit. The guidance scheme was changed from the previous modified version of the Lambert Aim Point Maneuver Mode used in Apollo to one that employs linear tangent guidance concepts. This document replaces the previous ascent phase equation document.

    4. Guidance for state attainment plans

      SciTech Connect

      Strait, R.

      1994-06-01

      Title I of the Clean Air act Amendments of 1990 significantly changed requirements for regulatory agencies to prepare state implementation plans that demonstrate attainment of the ozone National Ambient Air Quality Standards. State agencies now are required to submit plans that show how they will meet the standards by their attainment date. EPA has published a series of guidance documents to assist states in preparing their plans. In addition, the agency is developing software to assist states in projecting emissions and tracking reductions. This article summarizes the guidance documents and software program.

    5. Guidance of Nonlinear Systems

      NASA Technical Reports Server (NTRS)

      Meyer, George

      1997-01-01

      The paper describes a method for guiding a dynamic system through a given set of points. The paradigm is a fully automatic aircraft subject to air traffic control (ATC). The ATC provides a sequence of way points through which the aircraft trajectory must pass. The way points typically specify time, position, and velocity. The guidance problem is to synthesize a system state trajectory which satisfies both the ATC and aircraft constraints. Complications arise because the controlled process is multi-dimensional, multi-axis, nonlinear, highly coupled, and the state space is not flat. In addition, there is a multitude of possible operating modes, which may number in the hundreds. Each such mode defines a distinct state space model of the process by specifying the state space coordinatization, the partition of the controls into active controls and configuration controls, and the output map. Furthermore, mode transitions must be smooth. The guidance algorithm is based on the inversion of the pure feedback approximations, which is followed by iterative corrections for the effects of zero dynamics. The paper describes the structure and modules of the algorithm, and the performance is illustrated by several example aircraft maneuvers.

    6. The effect of selected alloying element additions on properties of Mg-based alloy as bioimplants: A literature review

      NASA Astrophysics Data System (ADS)

      Zhang, Li-Nan; Hou, Zeng-Tao; Ye, Xin; Xu, Zhao-Bin; Bai, Xue-Ling; Shang, Peng

      2013-09-01

      This review investigates the current application limitations of Mg and Mg alloys. The key issues hindering the application of biodegradable Mg alloys as implants are their fast degradation rate and biological consideration. We have discussed the effect of some selected alloying element additions on the properties of the Mg-based alloy, especially the nutrient elements in human (Zn, Mn, Ca, Sr). Different grain sizes, phase constituents and distributions consequently influence the mechanical properties of the Mg alloys. Solution strengthening and precipitation strengthening are enhanced by the addition of alloying elements, generally improving the mechanical properties. Besides, the hot working process can also improve the mechanical properties. Combination of different processing steps is suggested to be adopted in the fabrication of Mg-based alloys. Corrosion properties of these Mg-based alloys have been measured in vitro and in vivo. The degradation mechanism is also discussed in terms of corrosion types, rates, byproducts and response of the surrounding tissues. Moreover, the clinical response and requirements of degradable implants are presented, especially for the nutrient elements (Ca, Mn, Zn, Sr). This review provides information related to different Mg alloying elements and presents the promising candidates for an ideal implant.

    7. Cumulative dietary exposure to a selected group of pesticides of the triazole group in different European countries according to the EFSA guidance on probabilistic modelling.

      PubMed

      Boon, Polly E; van Donkersgoed, Gerda; Christodoulou, Despo; Crépet, Amélie; D'Addezio, Laura; Desvignes, Virginie; Ericsson, Bengt-Göran; Galimberti, Francesco; Ioannou-Kakouri, Eleni; Jensen, Bodil Hamborg; Rehurkova, Irena; Rety, Josselin; Ruprich, Jiri; Sand, Salomon; Stephenson, Claire; Strömberg, Anita; Turrini, Aida; van der Voet, Hilko; Ziegler, Popi; Hamey, Paul; van Klaveren, Jacob D

      2015-05-01

      The practicality was examined of performing a cumulative dietary exposure assessment according to the requirements of the EFSA guidance on probabilistic modelling. For this the acute and chronic cumulative exposure to triazole pesticides was estimated using national food consumption and monitoring data of eight European countries. Both the acute and chronic cumulative dietary exposures were calculated according to two model runs (optimistic and pessimistic) as recommended in the EFSA guidance. The exposures obtained with these model runs differed substantially for all countries, with the highest exposures obtained with the pessimistic model run. In this model run, animal commodities including cattle milk and different meat types, entered in the exposure calculations at the level of the maximum residue limit (MRL), contributed most to the exposure. We conclude that application of the optimistic model run on a routine basis for cumulative assessments is feasible. The pessimistic model run is laborious and the exposure results could be too far from reality. More experience with this approach is needed to stimulate the discussion of the feasibility of all the requirements, especially the inclusion of MRLs of animal commodities which seem to result in unrealistic conclusions regarding their contribution to the dietary exposure. PMID:25125392

    8. Effects of a selection of additives on in vitro ruminal methanogenesis and in situ and in vivo NDF digestibility.

      PubMed

      Pirondini, Mario; Colombini, Stefania; Malagutti, Luca; Rapetti, Luca; Galassi, Gianluca; Zanchi, Raffaella; Crovetto, Gianni Matteo

      2015-01-01

      The effects of 18 essential oils, yeast, Quebracho tannin and Quillaja saponin on ruminal methane and gas production (GP) were studied in vitro. A lactating cow diet was incubated with rumen inoculum. Doses of the additives (mg/L) were: essential oils = 500; tannin = 67; yeast = 8.35 and 16.7; and saponin = 300. Lemongrass, estragole, eugenol, geraniol, limonen, thyme oil and thymol produced less gas (overall mean 33.8 mL/200 mg dry matter (DM)) than control (43.6 mL/200 mg DM; P < 0.001). Methane produced (mL/200 mg DM) by guaiacol (10.7), lemongrass (9.6), limonene (11.4), thyme oil (10.9) and thymol (2.1) was lower than control (12.5) (P < 0.001). Methane percentage on total GP was lower (P < 0.001) for cinnamic alcohol (25.4), guaiacol (24.5), thymol (19.7) and vanillin (26.3) than control (28.8). In a second experiment, thymol, guaiacol and yeast were added to the diet of dry fistulated cows to determine in situ neutral detergent fiber digestibility (NDFD) of six forages and in vivo dietary NDFD. Thymol and yeast decreased in situ NDFD after 24 h (33.9% and 33.5% vs. 38.1%; P = 0.008). Thymol decreased in vivo total tract NDFD (40.8% vs. 51.4%; P = 0.02). Differences in GP and methane levels were registered within classes of additives. A careful selection of additives may allow for the manipulation of ruminal fermentation. PMID:25039484

    9. Computer simulation for the growing probability of additional offspring with an advantageous reversal allele in the decoupled continuous-time mutation-selection model

      NASA Astrophysics Data System (ADS)

      Gill, Wonpyong

      2016-01-01

      This study calculated the growing probability of additional offspring with the advantageous reversal allele in an asymmetric sharply-peaked landscape using the decoupled continuous-time mutation-selection model. The growing probability was calculated for various population sizes, N, sequence lengths, L, selective advantages, s, fitness parameters, k and measuring parameters, C. The saturated growing probability in the stochastic region was approximately the effective selective advantage, s*, when C≫1/Ns* and s*≪1. The present study suggests that the growing probability in the stochastic region in the decoupled continuous-time mutation-selection model can be described using the theoretical formula for the growing probability in the Moran two-allele model. The selective advantage ratio, which represents the ratio of the effective selective advantage to the selective advantage, does not depend on the population size, selective advantage, measuring parameter and fitness parameter; instead the selective advantage ratio decreases with the increasing sequence length.

    10. Guidance molecules in lung cancer

      PubMed Central

      Nasarre, Patrick; Potiron, Vincent; Drabkin, Harry

      2010-01-01

      Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer development, tumor angiogenesis and metastasis. This review is primarily focused on their functions in lung cancer and their involvement in lung development is also presented. Five guidance molecule families and their corresponding receptors are described, including the semaphorins/neuropilins/plexins, ephrins and Eph receptors, netrin/DCC/UNC5, Slit/Robo and Notch/Delta. In addition, the possibility to target these molecules as a therapeutic approach in cancer is discussed. PMID:20139699

    11. The revised HSE fatigue guidance

      SciTech Connect

      Stacey, A.; Sharp, J.V.

      1995-12-31

      Fatigue cracking has been a principal cause of damage to North Sea structures and consequently considerable attention has been given to the development of guidance for the prediction of fatigue performance. The fatigue guidance of the Offshore Safety Division of the Health and Safety Executive (HSE) was recently revised and published, following a significant offshore industry review in the period 1987 to 1990, and is based on the results of a considerable amount of research and development work on the fatigue behavior of welded tubular and plated joints. As a result of this review, the revised fatigue guidance incorporates several new clauses and recommendations. The revised recommendations apply to joint classification, basic design S-N curves for welded joints and cast or forged steel components, the thickness effect, the effects of environment and the treatment of low and high stress ranges. Additionally, a new appendix on the derivation of stress concentration factors is included. The new clauses cover high strength steels, bolts and threaded connectors, moorings, repaired joints and the use of fracture mechanics analysis. This paper presents an overview of the revisions to the fatigue guidance, the associated background technical information and aspects of the fatigue behavior of offshore structures which are considered to require further investigation. 67 refs., 7 figs., 8 tabs.

    12. Stressor Identification Guidance Document

      EPA Science Inventory

      EPA has made availabile the Stressor Identification Guidance Document (EPA 822-B-00-025) published under the authority of Section 304(a)(2) of the Clean Water Act (CWA). This technical guidance doc...

    13. Aiding Vertical Guidance Understanding

      NASA Technical Reports Server (NTRS)

      Feary, Michael; McCrobie, Daniel; Alkin, Martin; Sherry, Lance; Polson, Peter; Palmer, Everett; McQuinn, Noreen

      1998-01-01

      A two-part study was conducted to evaluate modern flight deck automation and interfaces. In the first part, a survey was performed to validate the existence of automation surprises with current pilots. Results indicated that pilots were often surprised by the behavior of the automation. There were several surprises that were reported more frequently than others. An experimental study was then performed to evaluate (1) the reduction of automation surprises through training specifically for the vertical guidance logic, and (2) a new display that describes the flight guidance in terms of aircraft behaviors instead of control modes. The study was performed in a simulator that was used to run a complete flight with actual airline pilots. Three groups were used to evaluate the guidance display and training. In the training, condition, participants went through a training program for vertical guidance before flying the simulation. In the display condition, participants ran through the same training program and then flew the experimental scenario with the new Guidance-Flight Mode Annunciator (G-FMA). Results showed improved pilot performance when given training specifically for the vertical guidance logic and greater improvements when given the training and the new G-FMA. Using actual behavior of the avionics to design pilot training and FMA is feasible, and when the automated vertical guidance mode of the Flight Management System is engaged, the display of the guidance mode and targets yields improved pilot performance.

    14. Evaluating Guidance Activities.

      ERIC Educational Resources Information Center

      Sanborn, Marshall P.

      This report discusses one of the consistent problems in school counseling and guidance-that of furnishing concrete evidence concerning the effects of counseling and guidance activities on the development of children. The following causal factors are discussed: (1) the difficulty of pinning down abstractly stated goals in an operational manner at…

    15. Corporate information management guidance

      SciTech Connect

      1997-08-01

      At the request of the Department of Energy`s (DOE) Information Management (IM) Council, IM representatives from nearly all Headquarters (HQ) organizations have been meeting over the past year as the Corporate Guidance Group (CGG) to develop useful and sound corporate information management (IM) guidance. The ability of the Department`s IM community to develop such unified guidance continues to be critical to the success of future Departmental IM planning processes and the establishment of a well-coordinated IM environment between Headquarters and field organizations. This report, with 26 specific corporate IM guidance items documented and unanimously agreed to, as well as 12 items recommended for further development and 3 items deferred for future consideration, represents a highly successful effort by the IM community. The effort has proven that the diverse DOE organizations can put aside individual preferences and work together towards a common and mutually beneficial goal. In examining most areas and issues associated with information management in the Department, they have developed specific, far-reaching, and useful guidance. The IM representatives recommend that the documented guidance items provided in this report and approved by the DOE IM Council be followed by all IM organizations. The representatives also strongly recommend that the guidance process developed by the CGG be the single process for developing corporate IM guidance.

    16. Ascent Guidance Comparisons

      NASA Technical Reports Server (NTRS)

      Hanson, John M.; Shrader, M. Wade; Cruzen, Craig A.

      1995-01-01

      This paper contains results from ascent guidance studies conducted at the NASA Marshall Space Flight Center. The studies include investigation of different guidance schemes for a variety of potential launch vehicles. Criteria of a successful ascent guidance scheme are low operations cost, satisfaction of load indicator constraints, and maximization of performance. Results show that open-loop designs as a function of altitude or velocity are preferable to designs that are functions of time. Optimized open-loop trajectories can increase performance while maintaining load indicators within limits. Closed-loop atmospheric schemes that involve linear tangent steering or feedback of velocity terms for trajectory modification did not yield any improvement. Early release of vacuum closed-loop guidance, including use during solid rocket booster operation, yields some improvements. Evaluation of a closed-loop optimization scheme for flying through the atmosphere shows no advantages over open-loop optimization. Dispersion study results for several potential guidance schemes and launch vehicles are included in the paper and are not a discriminator between guidance schemes. The primary cost driver is mission operations philosophy, not choice of guidance scheme. More autonomous guidance schemes can help in movement towards a philosophy that would reduce operations costs.

    17. Guidance for Total Development.

      ERIC Educational Resources Information Center

      Van Hoose, William H.

      Elementary guidance, deriving much of its content from the developmental phenomena of middle childhood, is viewed as the maximization of human potentiality in the total range of the population. Included in the list of elementary school guidance objectives are (1) aiding academic development, (2) helping children develop health self-concepts, (3)…

    18. Shuttle entry guidance revisited

      NASA Technical Reports Server (NTRS)

      Mease, Kenneth D.; Kremer, Jean-Paul

      1992-01-01

      The Shuttle entry guidance concept is reviewed which is aimed at tracking a reference drag trajectory that leads to the specified range and velocity for the initiation of the terminal energy management phase. An approximate method of constructing the domain of attraction is proposed, and its validity is ascertained by simulation. An alternative guidance law yielding global exponential tracking in the absence of control saturation is derived using a feedback linearization method. It is noted that the alternative guidance law does not improve on the stability and performance of the current guidance law, for the operating domain and control capability of the Shuttle. It is suggested that the new guidance law with a larger operating domain and increased lift-to-drag capability would be superior.

    19. Shuttle entry guidance

      NASA Technical Reports Server (NTRS)

      Harpold, J. C.; Graves, C. A., Jr.

      1978-01-01

      This paper describes the design of the entry guidance for the Space Shuttle Orbiter. This guidance provides the steering commands for trajectory control from initial penetration of the earth's atmosphere until the terminal area guidance is activated at an earth-relative speed of 2500 fps. At this point, the Orbiter is at a distance of about 50 nmi from the runway threshold, and at an altitude of about 80,000 ft. The entry guidance design is based on an analytic solution of the equations of motion defining the drag acceleration profile that meets the terminal criteria of the entry flight while maintaining the flight within systems and operational constraints. Guidance commands, which are based on a control law that ensures damping of oscillatory type trajectory motion, are computed to steer the Orbiter to this drag acceleration profile.

    20. The cyclic oxidation resistance at 1200 C of beta-NiAl, FeAl, and CoAl alloys with selected third element additions

      NASA Technical Reports Server (NTRS)

      Barrett, C. A.; Titran, R. H.

      1992-01-01

      The intermetallic compounds Beta-NiAl, FeAl, and CoAl were tested in cyclic oxidation with selected third element alloy additions. Tests in static air for 200 1-hr cycles at 1200 C indicated by specific weight change/time data and x-ray diffraction analysis that the 5 at percent alloy additions did not significantly improve the oxidation resistance over the alumina forming baseline alloys without the additions. Many of the alloy additions were actually deleterious. Ta and Nb were the only alloy additions that actually altered the nature of the oxide(s) formed and still maintained the oxidation resistance of the protective alumina scale.

    1. The dilemma of guidance in scientific inquiry teaching

      NASA Astrophysics Data System (ADS)

      Furtak, Erin Marie

      2006-04-01

      The dilemma of guidance is a universal predicament that lies at the core of teaching. That is, teachers must simultaneously allow students to explore and learn on their own, while making sure that students' efforts result in the particular understandings that we want them to learn. The space between is occupied by some level of guidance provided by the teacher to support students' learning; yet the nature of that guidance remains unknown for many teachers. This study is a mixed-method, multiple case study that explores the guidance four teachers provided their students during discussions in scientific inquiry investigations. The scientific inquiry reform movement has been around for over 40 years, and has shown positive impact on student learning; however, present descriptions of scientific inquiry teaching are vague and have led to large variations in how teachers actually implement this method in their classrooms. Through a review of literature on the role of discourse in classrooms, I developed a collection of strategies that are indicative of more or less guidance provided by the teacher during discussions. I then applied this framework in a larger study that examined the impact of formative assessment on teacher's teaching a middle school, physical science unit on sinking and floating that helps students develop a relative-density based, universal explanation for sinking and floating. From the 12 teachers who were trained to use this curriculum the larger study, I selected four for this dissertation. Two of these teachers had students who showed higher learning gains from pre- to posttests of student learning, while the other two teachers' students showed lower learning gains. This dissertation used three sources of data---videotapes of classroom discussions, teacher interviews, and measures of student learning---to explore the nature of guidance and its relationship to student learning. The four teachers' lessons were examined and their whole

    2. Next Generation Advanced Video Guidance Sensor

      NASA Technical Reports Server (NTRS)

      Lee, Jimmy; Spencer, Susan; Bryan, Tom; Johnson, Jimmie; Robertson, Bryan

      2008-01-01

      The first autonomous rendezvous and docking in the history of the U.S. Space Program was successfully accomplished by Orbital Express, using the Advanced Video Guidance Sensor (AVGS) as the primary docking sensor. The United States now has a mature and flight proven sensor technology for supporting Crew Exploration Vehicles (CEV) and Commercial Orbital Transport. Systems (COTS) Automated Rendezvous and Docking (AR&D). AVGS has a proven pedigree, based on extensive ground testing and flight demonstrations. The AVGS on the Demonstration of Autonomous Rendezvous Technology (DART)mission operated successfully in "spot mode" out to 2 km. The first generation rendezvous and docking sensor, the Video Guidance Sensor (VGS), was developed and successfully flown on Space Shuttle flights in 1997 and 1998. Parts obsolescence issues prevent the construction of more AVGS. units, and the next generation sensor must be updated to support the CEV and COTS programs. The flight proven AR&D sensor is being redesigned to update parts and add additional. capabilities for CEV and COTS with the development of the Next, Generation AVGS (NGAVGS) at the Marshall Space Flight Center. The obsolete imager and processor are being replaced with new radiation tolerant parts. In addition, new capabilities might include greater sensor range, auto ranging, and real-time video output. This paper presents an approach to sensor hardware trades, use of highly integrated laser components, and addresses the needs of future vehicles that may rendezvous and dock with the International Space Station (ISS) and other Constellation vehicles. It will also discuss approaches for upgrading AVGS to address parts obsolescence, and concepts for minimizing the sensor footprint, weight, and power requirements. In addition, parts selection and test plans for the NGAVGS will be addressed to provide a highly reliable flight qualified sensor. Expanded capabilities through innovative use of existing capabilities will also be

    3. A GUIDANCE PROJECT TO INVESTIGATE CHARACTERISTICS, BACKGROUND, AND JOB EXPERIENCES OF SUCCESSFUL AND UNSUCCESSFUL ENTRY WORKERS IN THREE SELECTED INDUSTRIES. FINAL REPORT.

      ERIC Educational Resources Information Center

      GORMAN, ROBERT E.

      FIFTEEN CERTIFIED SECONDARY SCHOOL COUNSELORS PARTICIPATED IN AN ON-THE-JOB INVESTIGATION OF THREE SELECTED INDUSTRIES IN MONTANA--MINING, LUMBERING, AND CONSTRUCTION. THE PURPOSES WERE TO (1) PROVIDE THE PARTICIPATING COUNSELORS WITH ON-THE-JOB KNOWLEDGE ESSENTIAL FOR ENGAGING IN MORE EFFECTIVE VOCATIONAL COUNSELING OF SECONDARY SCHOOL STUDENTS…

    4. 78 FR 63220 - Guidance for Industry on Acute Bacterial Skin and Skin Structure Infections: Developing Drugs for...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-10-23

      ... an endpoint for which there is a well-defined treatment effect. The guidance also provides the... endpoints for ABSSSI were included in this guidance. In addition, this guidance reflects recent...

    5. Autonomous landing guidance program

      NASA Astrophysics Data System (ADS)

      Brown, John A.

      1996-05-01

      The Autonomous Landing Guidance program is partly funded by the US Government under the Technology Reinvestment Project. The program consortium consists of avionics and other equipment vendors, airlines and the USAF. A Sextant Avionique HUD is used to present flight symbology in cursive form as well as millimeter wave radar imagery from Lear Astronics equipment and FLIR Systems dual-channel, forward-looking, infrared imagery. All sensor imagery is presented in raster form. A future aim is to fuse all imagery data into a single presentation. Sensor testing has been accomplished in a Cessna 402 operated by the Maryland Advanced Development Laboratory. Development testing is under way in a Northwest Airlines simulator equipped with HUD and image simulation. Testing is also being carried out using United Airlines Boeing 727 and USAF C-135C (Boeing 707) test aircraft. The paper addresses the technology utilized in sensory and display systems as well as modifications made to accommodate the elements in the aircraft. Additions to the system test aircraft include global positioning systems, inertial navigation systems and extensive data collection equipment. Operational philosophy and benefits for both civil and military users are apparent. Approach procedures have been developed allowing use of Category 1 ground installations in Category 3 conditions.

    6. Regulatory guidance on soil cover systems

      SciTech Connect

      Kane, J.D.

      1991-12-31

      The US Nuclear Regulatory Commission (NRC) in September 1991, completed revisions to 14 sections of the Standard Review Plan (SRP) for the Review of a License Application for a Low-Level Radioactive Waste Disposal Facility. The major purposes of the SRP are to ensure the quality and uniformity of the NRC staff`s safety reviews, and to present a well-defined base from which to evaluate the acceptability of information and data provided in the Safety Analysis Report (SAR) portion of the license application. SRP 3.2, entitled, Design Considerations for Normal and Abnormal/Accident Conditions, was one of the sections that was revised by the NRC staff. This revision was completed to provide additional regulatory guidance on the important considerations that need to be addressed for the proper design and construction of soil cover systems that are to be placed over the LLW. The cover system over the waste is acknowledged to be one of the most important engineered barriers for the long-term stable performance of the disposal facility. The guidance in revised SRP 3.2 summarizes the previous efforts and recommendations of the US Army Corps of Engineers (COE), and a peer review panel on the placement of soil cover systems. NRC published these efforts in NUREG/CR-5432. The discussions in this paper highlight selected recommendations on soil cover issues that the NRC staff considers important for ensuring the safe, long-term performance of the soil cover systems. The development phases to be discussed include: (1) cover design; (2) cover material selection; (3) laboratory and field testing; (4) field placement control and acceptance; and (5) penetrations through the constructed covers.

    7. Growth behavior of additional offspring with a beneficial reversal allele in the asymmetric sharply-peaked landscape in the coupled discrete-time mutation-selection model

      NASA Astrophysics Data System (ADS)

      Gill, Wonpyong

      2013-01-01

      The probability of additional offspring with a beneficial reversal allele for growing to a size NC for a range of population sizes N, sequence lengths L, selective advantages s, and measuring parameters C was calculated for a haploid, asexual population in the coupled discrete-time mutation-selection model in an asymmetric sharply-peaked landscape with a positive selective advantage of the reversal allele over the optimal allele. The growing probability in the stochastic region was inversely proportional to the measuring parameter when C < 1 /Ns, bent when C ≈ 1/ Ns and saturated when C > 1/ Ns. The crossing time and the time dependence of the increase in relative density of the reversal allele in the coupled discrete-time mutation-selection model was approximated using the Wright-Fisher two-allele model with the same selective advantage and corresponding effective mutation rate. The growth behavior of additional offspring with the reversal allele in the asymmetric sharply-peaked landscape in the coupled discrete-time mutation-selection model was controlled by the selective advantage of the reversal allele compared to the optimal allele and could be described by using the Wright-Fisher two-allele model, in spite of there being many other alleles with lower fitness, and in spite of there being two alleles, the optimal and reversal allele, separated by a low-fitness valley with a tunable depth and width.

    8. Effects of the Addition of Ecklonia cava Powder on the Selected Physicochemical and Sensory Quality of White Pan Bread.

      PubMed

      Lee, Jun Ho; Choi, Dong Won

      2013-12-01

      Physicochemical properties and consumer perception of white pan bread as influenced by the addition of Ecklonia cava powder (ECP) were investigated. Freeze-dried Ecklonia cava were ground, sieved through a laboratory sieve and a fraction with particles less than 250 μm was used. Amount of ECP added (0~3%) to the bread was found to affect the bread quality significantly (P<0.05). pH, bread height, and volume of the control was significantly higher than others (P<0.05) and decreased significantly (P<0.05) with the addition of ECP. Moisture content showed no significant differences (P>0.05). There were distinctive color changes with the addition of the powder: L*- and a*-values decreased but b*-value increased significantly (P<0.05). The hardness of bread was found to increase but both cohesiveness and springiness showed a reverse trend with the addition of the powder. Consumer acceptance test indicated that ECP content 1% on wheat flour could be the recommended supplementation level for the consumers without sacrificing sensory quality. PMID:24551832

    9. The effect of haptic guidance and visual feedback on learning a complex tennis task.

      PubMed

      Marchal-Crespo, Laura; van Raai, Mark; Rauter, Georg; Wolf, Peter; Riener, Robert

      2013-11-01

      While haptic guidance can improve ongoing performance of a motor task, several studies have found that it ultimately impairs motor learning. However, some recent studies suggest that the haptic demonstration of optimal timing, rather than movement magnitude, enhances learning in subjects trained with haptic guidance. Timing of an action plays a crucial role in the proper accomplishment of many motor skills, such as hitting a moving object (discrete timing task) or learning a velocity profile (time-critical tracking task). The aim of the present study is to evaluate which feedback conditions-visual or haptic guidance-optimize learning of the discrete and continuous elements of a timing task. The experiment consisted in performing a fast tennis forehand stroke in a virtual environment. A tendon-based parallel robot connected to the end of a racket was used to apply haptic guidance during training. In two different experiments, we evaluated which feedback condition was more adequate for learning: (1) a time-dependent discrete task-learning to start a tennis stroke and (2) a tracking task-learning to follow a velocity profile. The effect that the task difficulty and subject's initial skill level have on the selection of the optimal training condition was further evaluated. Results showed that the training condition that maximizes learning of the discrete time-dependent motor task depends on the subjects' initial skill level. Haptic guidance was especially suitable for less-skilled subjects and in especially difficult discrete tasks, while visual feedback seems to benefit more skilled subjects. Additionally, haptic guidance seemed to promote learning in a time-critical tracking task, while visual feedback tended to deteriorate the performance independently of the task difficulty and subjects' initial skill level. Haptic guidance outperformed visual feedback, although additional studies are needed to further analyze the effect of other types of feedback visualization on

    10. Comprehensive Guidance Programs That Work.

      ERIC Educational Resources Information Center

      Gysbers, Norman C.; And Others

      This monograph describes how the comprehensive guidance model is transforming elementary-secondary school guidance and counseling programs in schools across the country. It incorporates the ideas and experiences of 12 guidance program developers in the actual use of the comprehensive guidance model in diverse school and cultural settings. The book…

    11. Comparative characterization of the physicochemical behavior and skin permeation of extruded DPPC liposomes modified by selected additives.

      PubMed

      Biruss, Babette; Valenta, Claudia

      2007-08-01

      The purpose of the present study was to analyze the influence of cholesterol (CHOL), stearylamine (SA), dicetyl phosphate (DCP), and xylenesulfonic acid sodium salt (SXS) in extruded DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) liposomes on their size, shape, and skin permeation of the model drug progesterone. The additives were incorporated in different molar ratios in relation to the phospholipid content. It could be proven that different molar ratios of the additives to lipids were able to modify liposome size, zeta potential, and the characteristic phase transition temperature of the lipids. In standard skin diffusion experiments SA and SXS increased the progesterone permeation two- to fourfold respectively after 48 h compared to the control. PMID:17301964

    12. Metal beta-diketonate chelates as emissions-reducing fuel additives and a lanthanide-containing polymeric selective sorbent

      SciTech Connect

      Williams, E.J.

      1985-01-01

      Metal chelates of the anion of H(tod), 2,2,7-trimethyl-3,5-octanedione, have been synthesized and studied for use as emissions-reducing fuel additives. The thermal stability and volatility of complexes containing Co(III), Ni(II), Mn(II) and Ce(IV) were examined. These metal complexes exhibit very high solubilities in solvents such as n-hexane and are unusually volatile and thermally stable compounds. The structure of Cu(tod)/sub 2/ was determined by x-ray crystallography. Tests using Mn(tod)/sub 3/, Cu(tod)/sub 2/ and Ce(tod)/sub 4/ as fuel additives for gasoline engines indicated that dissolution of Mn(tod)/sub 3/ in test fuels can lower carbon monoxide levels in exhaust gas. The total hydrocarbon concentration and the relative concentrations of twenty hydrocarbon compounds in the exhaust were unaffected by the addition of these fuel additives to test fuel. A new porous polymer sorbent material has been developed which exhibits large breakthrough volumes for nucleophilic compounds. A styrene-divinylbenzene copolymer was modified such that fluorinated beta-diketone moieties were bonded to the phenyl rings in the polymer. Europium(III) ions were then incorporated in the modified polmer by complexation with the bound ligands. This study showed that the Eu(III)-containing polymer can retain nucleophilic species, such as aldehydes and ketones, when used as a trapping sorbent in air analysis. Apparently the retention of these compounds occurs via complexation with immobilized Eu(III) ions. The retention is thermally reversible, which allows sorbed compounds to be desorbed for gas chromatographic analysis.

    13. Vocational Guidance and the Labour Market: Guidance to Transform or Guidance to Domesticate?

      ERIC Educational Resources Information Center

      Kann, Ulla

      1988-01-01

      Explores the conflict in guidance arising from the desire to consider the needs of society while guaranteeing individual freedom of choice. Discusses the theoretical basis of vocational guidance. Gives examples of "domestication" and "transformation" approaches to guidance and discusses the consequences of viewing guidance as a change strategy.(KO)

    14. A comparative evaluation of the effect of various additives on selected physical properties of white mineral trioxide aggregate

      PubMed Central

      Prasad, Anushree; Pushpa, Shankarappa; Arunagiri, Doraiswamy; Sawhny, Asheesh; Misra, Abhinav; Sujatha, Ramamurthy

      2015-01-01

      Aims: This study examined the setting time, compressive strength, and pH of white mineral trioxide aggregate (MTA) mixed with various additives: Calcium chloride (CaCl2), calcium formate (CaF), disodium hydrogen orthophosphate (Na2HPO4). Materials and Methods: Group 1 (Control) was obtained by mixing MTA with distilled water. In Groups 2 and 3, MTA containing 10% CaCl2 and 20% CaF, respectively, was mixed with distilled water. In Group 4, MTA was mixed with 15% Na2HPO4. Setting time, compressive strength, and pH of each group were examined. Statistical Analysis Used: Analysis was done using Statistical Package for Social Sciences (SPSS) version 14. A P-value < 0.05 was considered statistically significant. Comparison of mean values was done using analysis of variance (ANOVA) with post-hoc Games-Howell test. Results: The setting time of test groups were significantly shorter than that of control group (P < 0.001). The compressive strengths of test groups were lower than that of control group (P < 0.001). The pH value obtained for Groups 3 and 4 were higher than that of the control group (P < 0.001). Conclusions: Study result showed that additives significantly reduced the setting time of MTA and also maintained the pH at a high value. However, there was not much improvement in the compressive strength of the material. PMID:26069412

    15. Selection of autochthonous lactic acid bacteria from goat dairies and their addition to evaluate the inhibition of Salmonella typhi in artisanal cheese.

      PubMed

      Ferrari, Iris da Silva; de Souza, Jane Viana; Ramos, Cintia Lacerda; da Costa, Mateus Matiuzzi; Schwan, Rosane Freitas; Dias, Francesca Silva

      2016-12-01

      This study aimed to select autochthonous lactic acid bacteria (LAB) with probiotic and functional properties from goat dairies and test their addition to artisanal cheese for the inhibition of Salmonella typhi. In vitro tests, including survival in the gastrointestinal tract (GIT), auto- and co-aggregation, the hemolytic test, DNase activity, antimicrobial susceptibility, antibacterial activity, tolerance to NaCl and exopolysaccharide (EPS), gas and diacetyl production were conducted for sixty isolates. Based on these tests, four LAB isolates (UNIVASF CAP 16, 45, 84 and 279) were selected and identified. Additional tests, such as production of lactic and citric acids by UNIVASF CAP isolates were performed in addition to assays of bile salt hydrolase (BSH), β-galactosidase and decarboxylase activity. The four selected LAB produced high lactic acid (>17 g/L) and low citric acid (0.2 g/L) concentrations. All selected strains showed BSH and β-galactosidase activity and none showed decarboxylase activity. Three goat cheeses (1, 2 and control) were produced and evaluated for the inhibitory action of selected LAB against Salmonella typhi. The cheese inoculated with LAB (cheese 2) decreased 0.38 log10 CFU/g of S. Typhy population while in the cheese without LAB inoculation (cheese 1) the pathogen population increased by 0.29 log units. Further, the pH value increased linearly over time, by 0.004 units per day in cheese 1. In the cheese 2, the pH value decreased linearly over time, by 0.066 units per day. The cocktail containing selected Lactobacillus strains with potential probiotic and technological properties showed antibacterial activity against S. typhi in vitro and in artisanal goat cheese. Thus, goat milk is important source of potential probiotic LAB which may be used to inhibit the growth of Salmonella population in cheese goat, contributing to safety and functional value of the product. PMID:27554143

    16. A mathematical approach to optimal selection of dose values in the additive dose method of ERP dosimetry

      SciTech Connect

      Hayes, R.B.; Haskell, E.H.; Kenner, G.H.

      1996-01-01

      Additive dose methods commonly used in electron paramagnetic resonance (EPR) dosimetry are time consuming and labor intensive. We have developed a mathematical approach for determining optimal spacing of applied doses and the number of spectra which should be taken at each dose level. Expected uncertainitites in the data points are assumed to be normally distributed with a fixed standard deviation and linearity of dose response is also assumed. The optimum spacing and number of points necessary for the minimal error can be estimated, as can the likely error in the resulting estimate. When low doses are being estimated for tooth enamel samples the optimal spacing is shown to be a concentration of points near the zero dose value with fewer spectra taken at a single high dose value within the range of known linearity. Optimization of the analytical process results in increased accuracy and sample throughput.

    17. Effect of high energy β-radiation and addition of triallyl isocyanurate on the selected properties of polylactide

      NASA Astrophysics Data System (ADS)

      Malinowski, Rafał

      2016-06-01

      Comparison of some changes occurring in polylactide (PLA) due to high energy β-radiation and addition of triallyl isocyanurate (TAIC) was the main objective of the present study. It was found that irradiation of PLA by high energy β-radiation causes essential changes in its properties, that undergoes mainly degradation, to form a porous structure. The PLA degradation can be diminished by introduction into the polymer matrix of a low-molecular mass multifunctional compound like TAIC. Upon the electron radiation, effective crosslinking of PLA by TAIC occurs. Application of TAIC favorably influences hindering of the PLA degradation or, when the doses are very large, diminishes worsening of the PLA functional qualities. It was also found that the optimum crosslinking of PLA is obtained when the electron radiation doses of the range of 40-200 kGy are applied and the amount of TAIC equal 3-5 wt% is used.

    18. Selective laser melting additive manufactured Inconel 718 superalloy parts: High-temperature oxidation property and its mechanisms

      NASA Astrophysics Data System (ADS)

      Jia, Qingbo; Gu, Dongdong

      2014-10-01

      This work presented a comprehensive study of high-temperature oxidation behaviors and mechanisms of Selective laser melting (SLM) processed Inconel 718 superalloy parts using different methods including isothermal oxidation testing, X-ray diffraction, scanning electron microscopy and energy dispersive X-ray spectroscopy. The experimental results revealed that the oxidation process of the tested parts processed at a lower volumetric laser energy density experienced the severe spallation. On reasonably increasing the applied volumetric laser energy density, the oxidation kinetics of the as-produced parts obeyed a parabolic law, exhibiting the significantly improved oxidation resistance performance. The constitutional phases within the oxidation film were identified and the corresponding formation mechanisms were elucidated in detail according to the thermodynamic principles. The cross-sectional morphologies of oxidized Inconel 718 parts indicated that the oxidation microstructure mainly consisted of an external oxidation layer and an internal oxidation zone. The oxidation process was controlled by the outward diffusion of oxide forming elements and inward penetration of oxygen, by which the interaction mechanisms between the microstructures and internal oxidation zones were clarified. On the basis of the experimental results and theoretical analyses, the physical oxidation mechanisms were accordingly established to illustrate the oxidation behaviors of SLM-processed Inconel 718 parts at elevated operative temperatures.

    19. Additional Selection for Insecticide Resistance in Urban Malaria Vectors: DDT Resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso

      PubMed Central

      Jones, Christopher M.; Toé, Hyacinthe K.; Sanou, Antoine; Namountougou, Moussa; Hughes, Angela; Diabaté, Abdoulaye; Dabiré, Roch; Simard, Frederic; Ranson, Hilary

      2012-01-01

      In the city of Bobo-Dioulasso in Burkina Faso, Anopheles arabiensis has superseded Anopheles gambiae s.s. as the major malaria vector and the larvae are found in highly polluted habitats normally considered unsuitable for Anopheles mosquitoes. Here we show that An. gambiae s.l. adults emerging from a highly polluted site in the city centre (Dioulassoba) have a high prevalence of DDT resistance (percentage mortality after exposure to diagnostic dose = 65.8% in the dry season and 70.4% in the rainy season, respectively). An investigation into the mechanisms responsible found an unexpectedly high frequency of the 1014S kdr mutation (allele frequency = 0.4), which is found at very low frequencies in An. arabiensis in the surrounding rural areas, and an increase in transcript levels of several detoxification genes, notably from the glutathione transferase and cytochrome P450 gene families. A number of ABC transporter genes were also expressed at elevated levels in the DDT resistant An. arabiensis. Unplanned urbanisation provides numerous breeding grounds for mosquitoes. The finding that Anopheles mosquitoes adapted to these urban breeding sites have a high prevalence of insecticide resistance has important implications for our understanding of the selective forces responsible for the rapid spread of insecticide resistant populations of malaria vectors in Africa. PMID:23049917

    20. From Pan-Reactive KV7 Channel Opener to Subtype Selective Opener/Inhibitor by Addition of a Methyl Group

      PubMed Central

      Blom, Sigrid Marie; Rottländer, Mario; Kehler, Jan; Bundgaard, Christoffer; Schmitt, Nicole; Jensen, Henrik Sindal

      2014-01-01

      The voltage-gated potassium channels of the KV7 family (KV7.1–5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in developing KV7 channel active drugs has been to identify compounds capable of discriminating between the neuronally expressed subtypes (KV7.2–5), aiding the identification of the subunit composition of KV7 currents in various tissues, and possessing better therapeutic potential for particular indications. By taking advantage of the structure-activity relationship of acrylamide KV7 channel openers and the effects of these compounds on mutant KV7 channels, we have designed and synthesized a novel KV7 channel modulator with a unique profile. The compound, named SMB-1, is an inhibitor of KV7.2 and an activator of KV7.4. SMB-1 inhibits KV7.2 by reducing the current amplitude and increasing the time constant for the slow component of the activation kinetics. The activation of KV7.4 is seen as an increase in the current amplitude and a slowing of the deactivation kinetics. Experiments studying mutant channels with a compromised binding site for the KV7.2–5 opener retigabine indicate that SMB-1 binds within the same pocket as retigabine for both inhibition of KV7.2 and activation of KV7.4. SMB-1 may serve as a valuable tool for KV7 channel research and may be used as a template for further design of better subtype selective KV7 channel modulators. A compound with this profile could hold novel therapeutic potential such as the treatment of both positive and cognitive symptoms in schizophrenia. PMID:24956197

    1. Aeromagnetic map and selected aeroradiometric data for the Ellicott Rock Wilderness and additions, South Carolina, North Carolina, and Georgia

      USGS Publications Warehouse

      Luce, Robert W.; Daniels, David L.

      1985-01-01

      The aeromagnetic and aeroradiometric data presented herin for the Ellicott Rock Wilderness and additions are taken from an airborne survey that covered a larger area in Georgia, North Carolina and South Carolina, and that was flown in December 1980 and January 1981 under contract to the U.S. Geological Survey. The flight lines were oriented northwest-southeast, approximately perpendicular to the general strike of the geology, at 0.5-mi (0.8-km) separation and at a nominal altitude of 500 ft (150 m) above mean terrain. A small amount of areomagnetic data from previous survey (Riggle and others, 1980) along the southeast edge of the study area is based on east-west flight lines spaced 1 mi (1.6 km) apart. Because of the rugged topography in the region, holding the airplane at a constant elevation abive the terrain was not possible. Actual ground clearance over short distances ranged between about 200 and 1200 ft. The International Geomagnetic Reference Field (IGRF) has been removed from the magnetic data (Barraclough and Fabiano, 1975) and 5000 gammas were added to make all values positive. 

    2. Creep deformation and fracture of a Cr/Mo/V bolting steel containing selected trace-element additions

      NASA Astrophysics Data System (ADS)

      Larouk, Z.; Pilkington, R.

      1999-08-01

      The article reports the creep behavior, at 565 °C, of 1Cr1Mo0.75V (Ti, B) (Durehete D1055) steel, in each of two grain sizes and doped with individual trace elements such as P, As, and Sn, in comparison to a reference cast of the base material containing 0.08 wt pct Ti. The addition of the trace elements P, As, or Sn (each <0.045 wt pct) appears to produce no significant effect on creep strength or creep crack-growth resistance at 565 °C. The fine-grained material shows low creep strength but notch strengthening, while the coarse-grained material shows higher creep strength and exhibits notch weakening for test times up to 2750 hours. From creep crack-growth tests, it appears that the C* parameter is not appropriate for correlating the creep crack-growth rate under the present test conditions. The parameters K I or σ net are found to correlate better, but, from the present data, it is not possible to judge which of these parameters is more appropriate for general use. It is suggested that the presence of Ti in CrMoV steels has an inhibiting effect on trace-element embrittlement.

    3. Selective hydrogenation of furan-containing condensation products as a source of biomass-derived diesel additives.

      PubMed

      Balakrishnan, Madhesan; Sacia, Eric R; Bell, Alexis T

      2014-10-01

      In this study, we demonstrate that while the energy density and lubricity of the C15 and C16 products of furan condensation of biomass-derived aldehydes with 2-methylfuran are consistent with requirements for diesel, these products do not meet specifications for cetane number and pour point due to their aromatic furan rings. However, a novel class of products that fully meet or exceed most specifications for diesel can be produced by converting the furan rings in these compounds to cyclic ether moieties. Full hydrodeoxygenation of furan condensation products to alkanes would require 55-60% higher hydrogen demand, starting from biomass, compared to the products of furan ring saturation, providing an additional incentive to support the saturated products. We also report here on a tunable class of catalysts that contain Pd nanoparticles supported on ionic liquid-modified SiO2 that can achieve complete saturation of the furan rings in yields of 95% without opening these rings. PMID:25169952

    4. Selection and optimization of transfection enhancer additives for increased virus-like particle production in HEK293 suspension cell cultures.

      PubMed

      Cervera, Laura; Fuenmayor, Javier; González-Domínguez, Irene; Gutiérrez-Granados, Sonia; Segura, Maria Mercedes; Gòdia, Francesc

      2015-12-01

      The manufacturing of biopharmaceuticals in mammalian cells typically relies on the use of stable producer cell lines. However, in recent years, transient gene expression has emerged as a suitable technology for rapid production of biopharmaceuticals. Transient gene expression is particularly well suited for early developmental phases, where several potential therapeutic targets need to be produced and tested in vivo. As a relatively new bioprocessing modality, a number of opportunities exist for improving cell culture productivity upon transient transfection. For instance, several compounds have shown positive effects on transient gene expression. These transfection enhancers either facilitate entry of PEI/DNA transfection complexes into the cell or nucleus or increase levels of gene expression. In this work, the potential of combining transfection enhancers to increase Gag-based virus-like particle production levels upon transfection of suspension-growing HEK 293 cells is evaluated. Using Plackett-Burman design of experiments, it is first tested the effect of eight transfection enhancers: trichostatin A, valproic acid, sodium butyrate, dimethyl sulfoxide (DMSO), lithium acetate, caffeine, hydroxyurea, and nocodazole. An optimal combination of compounds exhibiting the highest effect on gene expression levels was subsequently identified using a surface response experimental design. The optimal consisted on the addition of 20 mM lithium acetate, 3.36 mM valproic acid, and 5.04 mM caffeine which increased VLP production levels 3.8-fold, while maintaining cell culture viability at 94%. PMID:26278533

    5. Exploring Goals. Career Guidance.

      ERIC Educational Resources Information Center

      Mesa Public Schools, AZ.

      Materials contained in this career guidance unit are designed to enable senior high school students to relate their abilities scores from the Developed Abilities Performance (DAP) instrument to actual vocational areas and Long Range [occupational] Goals (LRG) for later indepth study. The length of the unit is six 55-minute periods. Instructional…

    6. Regulatory guidance document

      SciTech Connect

      1994-05-01

      The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

    7. Differentiating Classroom Guidance

      ERIC Educational Resources Information Center

      Akos, Patrick; Cockman, Caroline R.; Strickland, Cindy A.

      2007-01-01

      To differentiate is to make different, distinct, or specialized (Costello, 1994). Differentiation has become popular in education as an instructional philosophy aimed at equitably meeting the learning needs of all students in the classroom. Differentiated planning and delivery of classroom guidance is also necessary for appropriate school…

    8. The Counseling & Guidance Curriculum.

      ERIC Educational Resources Information Center

      Ediger, Marlow

      Counseling and guidance services are vital in any school curriculum. Counselors may themselves be dealing with students of diverse abilities and handicaps. Counselors may have to work with students affected by drug addiction, fetal alcohol syndrome, homelessness, poverty, Acquired Immune Deficiency Syndrome (AIDS) and divorce. Students may present…

    9. Primary Guidance Activities.

      ERIC Educational Resources Information Center

      Hauck, Ruth, Comp.

      Designed for the primary grades, the guidance activities in this document cover thirty-three topical areas: capabilities, changes, cooperation, criticism, differences, family, feelings, free time, friends, following directions, handicaps, honesty, improving environment, kindness, patience, paying attention, problem solving, rejection,…

    10. Developmental Guidance Program Implementation.

      ERIC Educational Resources Information Center

      Vernon, Ann; Strub, Richard

      This packet of materials was developed for workshops provided to teams of school counselors and administrators for the purpose of developing knowledge and competencies in the delivery of a comprehensive, sequential, developmental guidance program. Section I contains a rationale, definition, and description of program components. In section II…

    11. Vocational Development and Guidance.

      ERIC Educational Resources Information Center

      Tennyson, W. Wesley; And Others

      The vocational education volume considers questions of career development, the role of guidance in the school, vocational training, the relation of self-concept to vocational choice, and occupational information. Twenty-six papers deal with theories of vocational behavior, the success of vocational education programs, and testing information.…

    12. Direct carbon-carbon bond formation via reductive soft enolization: a syn-selective Mannich addition of α-iodo thioesters.

      PubMed

      Truong, Ngoc; Sauer, Scott J; Seraphin-Hatcher, Cyndie; Coltart, Don M

      2016-08-16

      The β-amino carboxylic acid moiety is a key feature of numerous important biologically active compounds. We describe a syn-selective direct Mannich addition reaction that uses α-iodo thioesters and sulfonyl imines and produces β-amino thioesters. Enolate formation is achieved by reductive soft enolization. The products of the reaction provide straightforward access to biologically important β-lactams through a variety of known reactions. PMID:27492274

    13. Method for continuous guidance of endoscopy

      NASA Astrophysics Data System (ADS)

      Merritt, Scott A.; Rai, Lav; Gibbs, Jason D.; Yu, Kun-Chang; Higgins, William E.

      2007-03-01

      Previous research has indicated that use of guidance systems during endoscopy can improve the performance and decrease the skill variation of physicians. Current guidance systems, however, rely on computationally intensive registration techniques or costly and error-prone electromagnetic (E/M) registration techniques, neither of which fit seamlessly into the clinical workflow. We have previously proposed a real-time image-based registration technique that addresses both of these problems. We now propose a system-level approach that incorporates this technique into a complete paradigm for real-time image-based guidance in order to provide a physician with continuously-updated navigational and guidance information. At the core of the system is a novel strategy for guidance of endoscopy. Additional elements such as global surface rendering, local cross-sectional views, and pertinent distances are also incorporated into the system to provide additional utility to the physician. Phantom results were generated using bronchoscopy performed on a rapid prototype model of a human tracheobronchial airway tree. The system has also been tested in ongoing live human tests. Thus far, ten such tests, focused on bronchoscopic intervention of pulmonary patients, have been run successfully.

    14. 77 FR 429 - Clarification and Further Guidance on the Fireworks Approvals Policy

      Federal Register 2010, 2011, 2012, 2013, 2014

      2012-01-05

      ... June 29, 2011 (76 FR 38053). Specifically, this document provides clarification and additional guidance... Pipeline and Hazardous Materials Safety Administration 49 CFR Part 173 Clarification and Further Guidance on the Fireworks Approvals Policy AGENCY: Pipeline and Hazardous Materials Safety...

    15. Survey of EPA and Other Federal Agency Scientific Data Management Policies and Guidance, 2009

      EPA Science Inventory

      The purpose of this study is to compile and assess internal Environmental Protection Agency (EPA) scientific data management (SDM) policies and guidance. Additionally, this study examines SDM policies and guidance from other Federal Agencies engaged in science and technology, an...

    16. Fine Guidance Sensing for Coronagraphic Observatories

      NASA Technical Reports Server (NTRS)

      Brugarolas, Paul; Alexander, James W.; Trauger, John T.; Moody, Dwight C.

      2011-01-01

      Three options have been developed for Fine Guidance Sensing (FGS) for coronagraphic observatories using a Fine Guidance Camera within a coronagraphic instrument. Coronagraphic observatories require very fine precision pointing in order to image faint objects at very small distances from a target star. The Fine Guidance Camera measures the direction to the target star. The first option, referred to as Spot, was to collect all of the light reflected from a coronagraph occulter onto a focal plane, producing an Airy-type point spread function (PSF). This would allow almost all of the starlight from the central star to be used for centroiding. The second approach, referred to as Punctured Disk, collects the light that bypasses a central obscuration, producing a PSF with a punctured central disk. The final approach, referred to as Lyot, collects light after passing through the occulter at the Lyot stop. The study includes generation of representative images for each option by the science team, followed by an engineering evaluation of a centroiding or a photometric algorithm for each option. After the alignment of the coronagraph to the fine guidance system, a "nulling" point on the FGS focal point is determined by calibration. This alignment is implemented by a fine alignment mechanism that is part of the fine guidance camera selection mirror. If the star images meet the modeling assumptions, and the star "centroid" can be driven to that nulling point, the contrast for the coronagraph will be maximized.

    17. Effect of selective Co addition on magnetic properties of Nd2(FeCo)14B/α-Fe nanocomposite magnets

      NASA Astrophysics Data System (ADS)

      Rong, C. Bing; Wang, Dapeng; Van Nguyen, Vuong; Daniil, Maria; Willard, Matthew A.; Zhang, Ying; Kramer, M. J.; Liu, J. Ping

      2013-01-01

      Nd2Fe14B/α-Fe-based hard/soft nanocomposite magnets with Co addition have been prepared by ball-milling and warm compaction. It was found that Co addition into the magnetically hard phase improves magnetic properties significantly, especially the remanence ratio and coercivity. The effect on the magnetic properties of the selective Co addition may be attributed to enhanced interdiffusion across the hard/soft interface that improves the interface conditions for effective interphase exchange coupling. By optimizing the Co content in the Nd15Fe79-xCoxB6 hard phase, an energy product value about 21 MG Oe can be obtained in the isotropic Nd2(FeCo)14B/α-(FeCo) nanocomposite magnets compared with 15 MG Oe of Nd2Fe14B/α-Fe nanocomposite magnets prepared under the same conditions with the same grain size and microstructure, owing to the strengthened intergranular exchange interactions.

    18. Middle School Students' Guidance and Counseling Needs

      ERIC Educational Resources Information Center

      Kesici, Sahin

      2007-01-01

      The purpose of this study is to determine the guidance and counseling needs of middle school (i.e., sixth, seventh, and eighth grades) students from their points of views by using qualitative research techniques. In addition, while collecting the data, semi-structured interview technique is used as a method of data collection. The study was…

    19. 49 CFR Appendix to Part 38 - Guidance Material

      Code of Federal Regulations, 2013 CFR

      2013-10-01

      ... 49 Transportation 1 2013-10-01 2013-10-01 false Guidance Material Appendix to Part 38... SPECIFICATIONS FOR TRANSPORTATION VEHICLES Pt. 38, App. Appendix to Part 38—Guidance Material This appendix contains materials of an advisory nature and provides additional information that should help the reader...

    20. Needed Concepts in Elementary Guidance.

      ERIC Educational Resources Information Center

      Warner, Tom, Ed.

      School administrators and developmental guidance is the topic of the first speech. Developmental guidance, concerned with personalizing the educational experience, should be available to each child to gain self-understanding. Major responsibilities of the elementary guidance department are pupil appraisal, consultation, and developmental…

    1. New Interpretations of Guidance Role

      ERIC Educational Resources Information Center

      Kerlan, Julius H.; Ryan, Charles W.

      1972-01-01

      A panoramic view of Guidance Division general sessions and workshops covering some exemplary career guidance programs, as well as such topics as career choice, leadership, evaluation, and program development and management. Presented at the Guidance division session of the American Vocational Association 1971 annual meeting. (Editor/MU)

    2. Trajectory shaping rendezvous guidance

      NASA Astrophysics Data System (ADS)

      Klumpp, A. R.

      The Space Station will bring a great increase in rendezvous traffic. Formerly, rendezvous has been expensive in terms of time and crew involvement. Multiple trajectory adjustments on separate orbits have been required to meet safety, lighting, and geometry requirements. This paper describes a new guidance technique in which the approach trajectory is shaped by a sequence of velocity increments in order to satisfy multiple constraints within a single orbit. The approach phase is planned before the mission, leaving a group of free parameters that are optimized by onboard guidance. Fuel penalties are typically a few percent, compared to unshaped Hohmann transfers, and total fuel costs can be less than those of more time-consuming ways of meeting the same requirements.

    3. Environmental guidance regulatory bulletin

      SciTech Connect

      1997-01-31

      This document describes the background on expanding public participation in the Resource Conservation and Recovery Act and DOE`s response. The bulletin also describes the changes made by the final rule to existing regulations, guidance provided by EPA in the preamble and in the revised RCRA Public Participation Manual, the relationship between public participation and environmental justice, and DOE`s recent public participation and environmental justice initiatives.

    4. Educators Guide to Free Guidance Materials: A Multimedia Guide. Thirteenth Annual Edition, 1974.

      ERIC Educational Resources Information Center

      Saterstrom, Mary H., Comp.; Steph, Joe A., Comp.

      This guide offers a complete listing of selected guidance films, filmstrips, slides, audiotapes, videotapes, scripts, charts, bulletins, pamphlets, exhibits, posters, and books available free to guidance personnel. For the convenience of the user, the guide is first grouped by areas of guidance, followed in turn by all filmstrips and slides, then…

    5. Product Evaluation of the Counseling and Career Guidance Component of the Detroit Desegregation Court Order.

      ERIC Educational Resources Information Center

      Fisher, Arnold

      The goal of the Counseling and Career Guidance Component of the Detroit (Michigan) school desegregation plan was to improve student effectiveness in the areas of personal, social, academic, and career development. Major program functions included individual and group counseling, program selection and placement guidance, career guidance, and…

    6. Safety of magnetic fusion facilities: Guidance

      SciTech Connect

      1996-05-01

      This document provides guidance for the implementation of the requirements identified in DOE-STD-6002-96, Safety of Magnetic Fusion Facilities: Requirements. This guidance is intended for the managers, designers, operators, and other personnel with safety responsibilities for facilities designated as magnetic fusion facilities. While the requirements in DOE-STD-6002-96 are generally applicable to a wide range of fusion facilities, this Standard, DOE-STD-6003-96, is concerned mainly with the implementation of those requirements in large facilities such as the International Thermonuclear Experimental Reactor (ITER). Using a risk-based prioritization, the concepts presented here may also be applied to other magnetic fusion facilities. This Standard is oriented toward regulation in the Department of Energy (DOE) environment as opposed to regulation by other regulatory agencies. As the need for guidance involving other types of fusion facilities or other regulatory environments emerges, additional guidance volumes should be prepared. The concepts, processes, and recommendations set forth here are for guidance only. They will contribute to safety at magnetic fusion facilities.

    7. Action Planning Mediates Guidance of Visual Attention from Working Memory.

      PubMed

      Feldmann-Wüstefeld, Tobias; Schubö, Anna

      2015-01-01

      Visual search is impaired when a salient task-irrelevant stimulus is presented together with the target. Recent research has shown that this attentional capture effect is enhanced when the salient stimulus matches working memory (WM) content, arguing in favor of attention guidance from WM. Visual attention was also shown to be closely coupled with action planning. Preparing a movement renders action-relevant perceptual dimensions more salient and thus increases search efficiency for stimuli sharing that dimension. The present study aimed at revealing common underlying mechanisms for selective attention, WM, and action planning. Participants both prepared a specific movement (grasping or pointing) and memorized a color hue. Before the movement was executed towards an object of the memorized color, a visual search task (additional singleton) was performed. Results showed that distraction from target was more pronounced when the additional singleton had a memorized color. This WM-guided attention deployment was more pronounced when participants prepared a grasping movement. We argue that preparing a grasping movement mediates attention guidance from WM content by enhancing representations of memory content that matches the distractor shape (i.e., circles), thus encouraging attentional capture by circle distractors of the memorized color. We conclude that templates for visual search, action planning, and WM compete for resources and thus cause interferences. PMID:26171241

    8. C-selective and diastereoselective alkyl addition to β,γ-alkynyl-α-imino esters with zinc(II)ate complexes.

      PubMed

      Hatano, Manabu; Yamashita, Kenji; Mizuno, Mai; Ito, Orie; Ishihara, Kazuaki

      2015-02-23

      Since umpolung α-imino esters contain three electrophilic centers, regioselective alkyl addition with traditional organometallic reagents has been a serious problem in the practical synthesis of versatile chiral α-amino acid derivatives. An unusual C-alkyl addition to α-imino esters using a Grignard reagent (RMgX)-derived zinc(II)ate was developed. Zinc(II)ate complexes consist of a Lewis acidic [MgX](+) moiety, a nucleophilic [R3 Zn](-) moiety, and 2 [MgX2 ]. Therefore, the ionically separated [R3 Zn](-) selectively attacks the imino carbon atom ,which is most strongly activated by chelation of [MgX](+) . In particular, chiral β,γ-alkynyl-α-imino esters can strongly promote highly regio- and diastereoselective C-alkylation because of structural considerations, and the corresponding optically active α-quaternary amino acid derivatives are obtained within 5 minutes in high to excellent yields. PMID:25598353

    9. Impacts of halogen additions on mercury oxidation, in a slipstream selective catalyst reduction (SCR), reactor when burning sub-bituminous coal.

      PubMed

      Cao, Yan; Gao, Zhengyang; Zhu, Jiashun; Wang, Quanhai; Huang, Yaji; Chiu, Chengchung; Parker, Bruce; Chu, Paul; Pant, Wei-Ping

      2008-01-01

      This paper presents a comparison of impacts of halogen species on the elemental mercury (Hg(0)) oxidation in a real coal-derived flue gas atmosphere. It is reported there is a higher percentage of Hg(0) in the flue gas when burning sub-bituminous coal (herein Powder River Basin (PRB) coal) and lignite, even with the use of selective catalytic reduction (SCR). The higher Hg(0)concentration in the flue gas makes it difficult to use the wet-FGD process for the mercury emission control in coal-fired utility boilers. Investigation of enhanced Hg(0) oxidation by addition of hydrogen halogens (HF, HCl, HBr, and HI) was conducted in a slipstream reactor with and without SCR catalysts when burning PRB coal. Two commercial SCR catalysts were evaluated. SCR catalyst no. 1 showed higher efficiencies of both NO reduction and Hg(0) oxidation than those of SCR catalyst no. 2. NH3 addition seemed to inhibit the Hg(0) oxidation, which indicated competitive processes between NH3 reduction and Hg(0) oxidation on the surface of SCR catalysts. The hydrogen halogens, in the order of impact on Hg(0) oxidation, were HBr, HI, and HCl or HF. Addition of HBr at approximately 3 ppm could achieve 80% Hg(0) oxidation. Addition of HI at approximately 5 ppm could achieve 40% Hg(0) oxidation. In comparison to the empty reactor, 40% Hg(0) oxidation could be achieved when HCl addition was up to 300 ppm. The enhanced Hg(0) oxidation by addition of HBr and HI seemed not to be correlated to the catalytic effects by both evaluated SCR catalysts. The effectiveness of conversion of hydrogen halogens to halogen molecules or interhalogens seemed to be attributed to their impacts on Hg(0) oxidation. PMID:18350905

    10. Impacts of halogen additions on mercury oxidation, in a slipstream selective catalyst reduction (SCR), reactor when burning sub-bituminous coal

      SciTech Connect

      Yan Cao; Zhengyang Gao; Jiashun Zhu; Quanhai Wang; Yaji Huang; Chengchung Chiu; Bruce Parker; Paul Chu; Wei-ping Pan

      2008-01-01

      This paper presents a comparison of impacts of halogen species on the elemental mercury (Hg(0)) oxidation in a real coal-derived flue gas atmosphere. It is reported there is a higher percentage of Hg(0) in the flue gas when burning sub-bituminous coal (herein Powder River Basin (PRB) coal) and lignite, even with the use of selective catalytic reduction (SCR). The higher Hg(0) concentration in the flue gas makes it difficult to use the wet-FGD process for the mercury emission control in coal-fired utility boilers. Investigation of enhanced Hg(0) oxidation by addition of hydrogen halogens (HF, HCl, HBr, and HI) was conducted in a slipstream reactor with and without SCR catalysts when burning PRB coal. Two commercial SCR catalysts were evaluated. SCR catalyst no. 1 showed higher efficiencies of both NO reduction and Hg(0) oxidation than those of SCR catalyst no. 2. NH{sub 3} addition seemed to inhibit the Hg(0) oxidation, which indicated competitive processes between NH{sub 3} reduction and Hg(0) oxidation on the surface of SCR catalysts. The hydrogen halogens, in the order of impact on Hg(0) oxidation, were HBr, HI, and HCl or HF. Addition of HBr at approximately 3 ppm could achieve 80% Hg(0) oxidation. Addition of HI at approximately 5 ppm could achieve 40% Hg(0) oxidation. In comparison to the empty reactor, 40% Hg(0) oxidation could be achieved when HCl addition was up to 300 ppm. The enhanced Hg(0) oxidation by addition of HBr and HI seemed not to be correlated to the catalytic effects by both evaluated SCR catalysts. The effectiveness of conversion of hydrogen halogens to halogen molecules or interhalogens seemed to be attributed to their impacts on Hg(0) oxidation. 30 refs., 4 figs.

    11. Halogen-free ionic liquid as an additive in zinc(II)-selective electrode: surface analyses as correlated to the membrane activity.

      PubMed

      Al-Asousi, Maryam F; Shoukry, Adel F; Bu-Olayan, Abdul Hadi

      2012-05-30

      Two conventional Zn(II) polyvinyl chloride (PVC) membrane electrodes have been prepared and characterized. They were based on dibenzo-24-crown-8 (DBC) as a neutral carrier, dioctyl phthalate (DOP) as a plasticizer, and potassium tetrakis (p-chlorophenyl) borate, KTpClPB or the halogen-free ionic liquid, tetraoctylammonium dodecylbenzene sulfonate [TOA][DBS] as an additive. The use of ionic liquid has been found to enhance the selectivity of the sensor. For each electrode, the surfaces of two membranes were investigated using X-ray photoelectron, ion-scattering spectroscopy and atomic force microscopy. One of the two membranes was conditioned by soaking it for 24 h in a 1.0×10(-3) M Zn(NO(3))(2) solution and the second was soaked in bi-distilled water for the same interval (24 h). Comparing the two surfaces indicated the following: (a) the high selectivity in case of using [TOA][DBS] as an additive is due to the extra mediation caused by the ionic liquid and (b) the working mechanism of the electrode is based on phase equilibrium at the surface of the membrane associated with ion transport through the bulk of the membrane. PMID:22608433

    12. Surface protein imprinted core-shell particles for high selective lysozyme recognition prepared by reversible addition-fragmentation chain transfer strategy.

      PubMed

      Li, Qinran; Yang, Kaiguang; Liang, Yu; Jiang, Bo; Liu, Jianxi; Zhang, Lihua; Liang, Zhen; Zhang, Yukui

      2014-12-24

      A novel kind of lysozyme (Lys) surface imprinted core-shell particles was synthesized by reversible addition-fragmentation chain transfer (RAFT) strategy. With controllable polymer shell chain length, such particles showed obviously improved selectivity for protein recognition. After the RAFT initial agent and template protein was absorbed on silica particles, the prepolymerization solution, with methacrylic acid and 2-hydroxyethyl methacrylate as the monomers, and N,N'-methylenebis(acrylamide) as the cross-linker, was mixed with the silica particles, and the polymerization was performed at 40 °C in aqueous phase through the oxidation-reduction initiation. Ater polymerization, with the template protein removal and destroying dithioester groups with hexylamine, the surface Lyz imprinted particles were obtained with controllable polymer chain length. The binding capacity of the Lys imprinted particles could reach 5.6 mg protein/g material, with the imprinting factor (IF) as 3.7, whereas the IF of the control material prepared without RAFT strategy was only 1.6. The absorption equilibrium could be achieved within 60 min. Moreover, Lys could be selectively recognized by the imprinted particles from both a four-proteins mixture and egg white sample. All these results demonstrated that these particles prepared by RAFT strategy are promising to achieve the protein recognition with high selectivity. PMID:25434676

    13. Phosphazene additives

      SciTech Connect

      Harrup, Mason K; Rollins, Harry W

      2013-11-26

      An additive comprising a phosphazene compound that has at least two reactive functional groups and at least one capping functional group bonded to phosphorus atoms of the phosphazene compound. One of the at least two reactive functional groups is configured to react with cellulose and the other of the at least two reactive functional groups is configured to react with a resin, such as an amine resin of a polycarboxylic acid resin. The at least one capping functional group is selected from the group consisting of a short chain ether group, an alkoxy group, or an aryloxy group. Also disclosed are an additive-resin admixture, a method of treating a wood product, and a wood product.

    14. 75 FR 29183 - Office of the Chief Financial Officer; Department of Agriculture Implementation of OMB Guidance...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2010-05-25

      ... final guidance for governmentwide nonprocurement debarment and suspension (70 FR 51863). This guidance... interim final guidance with changes (71 FR 66431). USDA's current regulation on nonprocurement debarment... governmentwide common rule on this subject issued November 26, 2003 (68 FR 66534, 66562). In addition to...

    15. Station-keeping guidance

      NASA Technical Reports Server (NTRS)

      Gustafson, D. E.; Kriegsman, B. A.

      1972-01-01

      The station-keeping guidance system is described, which is designed to automatically keep one orbiting vehicle within a prescribed zone fixed with respect to another orbiting vehicle. The active vehicle, i.e. the one performing the station-keeping maneuvers, is referred to as the shuttle. The other passive orbiting vehicle is denoted as the workshop. The passive vehicle is assumed to be in a low-eccentricity near-earth orbit. The primary navigation sensor considered is a gimballed tracking radar located on board the shuttle. It provides data on relative range and range rate between the two vehicles. Also measured are the shaft and trunnion axes gimbal angles. An inertial measurement unit (IMU) is provided on board the orbiter. The IMU is used at all times to provide an attitude reference for the vehicle. The IMU accelerometers are used periodically to monitor the velocity-correction burns applied to the shuttle during the station-keeping mode. The guidance system is capable of station-keeping the shuttle in any arbitrary position with respect to the workshop by periodically applying velocity-correction pulses to the shuttle.

    16. Bilinear tangent yaw guidance

      NASA Technical Reports Server (NTRS)

      Brusch, R. G.

      1979-01-01

      This paper presents a parametric yaw steering law which has been used to provide closed-loop yaw guidance for the launch of the HEAO (High Energy Astronomy Observatory) satellite mission using the Atlas/Centaur launch vehicle. This bilinear tangent steering law provides near optimal yaw steering for maneuvers requiring insertion into orbits with a specified inclination and node. Bilinear tangent steering is shown to be optimal in both the pitch and yaw planes when a uniform gravitational field is assumed. The conditions under which the general bilinear tangent laws degenerate into linear tangent and constant attitude laws are presented. The flight computer implementation of these laws in a rotating coordinate system using real-time integration of the equations of motion is detailed. Explicit solution of the parametric guidance equations requires the inflight solution of (2x2) two-point boundary value problems in the pitch and yaw planes. Excellent results are obtained even for very large (greater than 50 deg) out-of-plane steering angles.

    17. 32 CFR Appendix A to Part 155 - Additional Procedural Guidance

      Code of Federal Regulations, 2010 CFR

      2010-07-01

      ... prehearing conference. 10. The Administrative Judge may rule on questions of procedure, discovery, and evidence and shall conduct all proceedings in a fair, timely, and orderly manner. 11. Discovery by the applicant is limited to non-privileged documents and materials subject to control by the DOHA. Discovery...

    18. 9 CFR 392.9 - Availability of additional guidance.

      Code of Federal Regulations, 2011 CFR

      2011-01-01

      .... 392.9 Section 392.9 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.9... rulemaking may be found on the FSIS Web site at http://www/fsis.usda.gov/....

    19. 9 CFR 392.9 - Availability of additional guidance.

      Code of Federal Regulations, 2010 CFR

      2010-01-01

      .... 392.9 Section 392.9 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.9... rulemaking may be found on the FSIS Web site at http://www/fsis.usda.gov/....

    20. The National Literacy Strategy--Framework for Teaching: Additional Guidance.

      ERIC Educational Resources Information Center

      Department for Education and Skills, London (England).

      England's National Literacy Strategy is intended to raise standards of literacy for every student. Teachers should aim to include each student in the Literacy Hour. Evidence from the National Literacy Project (NLP), on which the national strategy is based, shows that students with widely varying needs can expect to improve their literacy skills in…

    1. Partial stabilization-based guidance.

      PubMed

      Shafiei, M H; Binazadeh, T

      2012-01-01

      A novel nonlinear missile guidance law against maneuvering targets is designed based on the principles of partial stability. It is demonstrated that in a real approach which is adopted with actual situations, each state of the guidance system must have a special behavior and asymptotic stability or exponential stability of all states is not realistic. Thus, a new guidance law is developed based on the partial stability theorem in such a way that the behaviors of states in the closed-loop system are in conformity with a real guidance scenario that leads to collision. The performance of the proposed guidance law in terms of interception time and control effort is compared with the sliding mode guidance law by means of numerical simulations. PMID:21963401

    2. Comparison of Thermal and Non-Thermal Processing of Swine Feed and the Use of Selected Feed Additives on Inactivation of Porcine Epidemic Diarrhea Virus (PEDV).

      PubMed

      Trudeau, Michaela P; Verma, Harsha; Sampedro, Fernando; Urriola, Pedro E; Shurson, Gerald C; McKelvey, Jessica; Pillai, Suresh D; Goyal, Sagar M

      2016-01-01

      Infection with porcine epidemic diarrhea virus (PEDV) causes diarrhea, vomiting, and high mortality in suckling pigs. Contaminated feed has been suggested as a vehicle of transmission for PEDV. The objective of this study was to compare thermal and electron beam processing, and the inclusion of feed additives on the inactivation of PEDV in feed. Feed samples were spiked with PEDV and then heated to 120-145°C for up to 30 min or irradiated at 0-50 kGy. Another set of feed samples spiked with PEDV and mixed with Ultracid P (Nutriad), Activate DA (Novus International), KEM-GEST (Kemin Agrifood), Acid Booster (Agri-Nutrition), sugar or salt was incubated at room temperature (~25°C) for up to 21 days. At the end of incubation, the virus titers were determined by inoculation of Vero-81 cells and the virus inactivation kinetics were modeled using the Weibull distribution model. The Weibull kinetic parameter delta represented the time or eBeam dose required to reduce virus concentration by 1 log. For thermal processing, delta values ranged from 16.52 min at 120°C to 1.30 min at 145°C. For eBeam processing, a target dose of 50 kGy reduced PEDV concentration by 3 log. All additives tested were effective in reducing the survival of PEDV when compared with the control sample (delta = 17.23 days). Activate DA (0.81) and KEM-GEST (3.28) produced the fastest inactivation. In conclusion, heating swine feed at temperatures over 130°C or eBeam processing of feed with a dose over 50 kGy are effective processing steps to reduce PEDV survival. Additionally, the inclusion of selected additives can decrease PEDV survivability. PMID:27341670

    3. Comparison of Thermal and Non-Thermal Processing of Swine Feed and the Use of Selected Feed Additives on Inactivation of Porcine Epidemic Diarrhea Virus (PEDV)

      PubMed Central

      Trudeau, Michaela P.; Verma, Harsha; Sampedro, Fernando; Urriola, Pedro E.; Shurson, Gerald C.; McKelvey, Jessica; Pillai, Suresh D.; Goyal, Sagar M.

      2016-01-01

      Infection with porcine epidemic diarrhea virus (PEDV) causes diarrhea, vomiting, and high mortality in suckling pigs. Contaminated feed has been suggested as a vehicle of transmission for PEDV. The objective of this study was to compare thermal and electron beam processing, and the inclusion of feed additives on the inactivation of PEDV in feed. Feed samples were spiked with PEDV and then heated to 120–145°C for up to 30 min or irradiated at 0–50 kGy. Another set of feed samples spiked with PEDV and mixed with Ultracid P (Nutriad), Activate DA (Novus International), KEM-GEST (Kemin Agrifood), Acid Booster (Agri-Nutrition), sugar or salt was incubated at room temperature (~25°C) for up to 21 days. At the end of incubation, the virus titers were determined by inoculation of Vero-81 cells and the virus inactivation kinetics were modeled using the Weibull distribution model. The Weibull kinetic parameter delta represented the time or eBeam dose required to reduce virus concentration by 1 log. For thermal processing, delta values ranged from 16.52 min at 120°C to 1.30 min at 145°C. For eBeam processing, a target dose of 50 kGy reduced PEDV concentration by 3 log. All additives tested were effective in reducing the survival of PEDV when compared with the control sample (delta = 17.23 days). Activate DA (0.81) and KEM-GEST (3.28) produced the fastest inactivation. In conclusion, heating swine feed at temperatures over 130°C or eBeam processing of feed with a dose over 50 kGy are effective processing steps to reduce PEDV survival. Additionally, the inclusion of selected additives can decrease PEDV survivability. PMID:27341670

    4. A guide to CERCLA site assessment. Environmental Guidance

      SciTech Connect

      Not Available

      1994-02-01

      This Pocket Guide is a condensed version of information provided in three EPA documents: Guidance for Performing Preliminary Assessments Under CERCLA, Guidance for Performing Site Inspections Under CERCLA, and Hazard Ranking System Guidance Manual. Additionally the guide provides a DOE perspective on site assessment issues and information on the Federal Agency Hazardous Waste Compliance Docket as well as data sources for DOE site assessments. The guide is intended to present this information in a simple, portable, and direct manner that will allow the user to effectively focus on those aspects of the site assessment process of interest. The guide is not intended as a substitute for the three EPA guidance documents mentioned previously. DOE investigators should be thoroughly familiar with the EPA guidance before conducting site assessments. Use this pocketguide as an overview of procedures and requirements and as a field guide.

    5. Endoscopic necrosectomy under fluoroscopic guidance – a single center experience

      PubMed Central

      Smoczyński, Marian; Jabłońska, Anna; Adrych, Krystian

      2015-01-01

      Introduction Our report presents a technique of necrotic tissue removal during transmural drainage of walled-off pancreatic necrosis (WOPN) that is an alternative to the one that has already been described in the literature. Aim To assess the effectiveness and safety of endoscopic necrosectomy performed during transmural drainage of symptomatic WOPN. Material and methods Within the years 2012–2013, 64 patients underwent endoscopic treatment of symptomatic WOPN in our center. Eight patients underwent endoscopic necrosectomy during transmural drainage. Fragments of necrotic tissues were removed from the collection's cavity under fluoroscopic guidance using a Dormia basket. The results and complications of treatment were compared retrospectively. Results Sixty-four patients with WOPN underwent transmural drainage under endoscopic ultrasonography (EUS) guidance. Eight patients (12.5%, 5 women and 3 men, mean age 57.25 years) were qualified for endoscopic necrosectomy. Transmural transgastric access was made in 7 patients and transduodenal access in 1 patient. Additional percutaneous drainage was used in 2 patients. Active drainage was continued for 24 days (11–44 days). The mean number of endoscopic procedures was 4.75 (3–9). The average number of necrosectomy procedures during drainage was 1.75 (1–4). Complications of endotherapy occurred in 2/8 (25%) patients, and they were not directly connected with necrosectomy. Therapeutic success after the end of active drainage was achieved in all patients. During a 6-month follow-up no recurrence of the collection was observed. Conclusions Endoscopic necrosectomy under fluoroscopic guidance is an effective and safe method of minimally invasive treatment in a selected group of patients with symptomatic WOPN. PMID:26240624

    6. Significant Promotion Effect of Mo Additive on a Novel Ce-Zr Mixed Oxide Catalyst for the Selective Catalytic Reduction of NO(x) with NH3.

      PubMed

      Ding, Shipeng; Liu, Fudong; Shi, Xiaoyan; Liu, Kuo; Lian, Zhihua; Xie, Lijuan; He, Hong

      2015-05-13

      A novel Mo-promoted Ce-Zr mixed oxide catalyst prepared by a homogeneous precipitation method was used for the selective catalytic reduction (SCR) of NO(x) with NH3. The optimal catalyst showed high NH3-SCR activity, SO2/H2O durability, and thermal stability under test conditions. The addition of Mo inhibited growth of the CeO2 particle size, improved the redox ability, and increased the amount of surface acidity, especially the Lewis acidity, all of which were favorable for the excellent NH3-SCR performance. It is believed that the catalyst is promising for the removal of NO(x) from diesel engine exhaust. PMID:25894854

    7. Microfluidic ratchets: from bacterial separation to sperm guidance

      NASA Astrophysics Data System (ADS)

      Condat, Carlos; Berdakin, Ivan; Marconi, Veronica; Guidobaldi, Alejandro; Giojalas, Laura; Silhanek, Alejandro; Jeyaram, Yogesh; Moshchalkov, Victor; Venken, Lyn; Vanderleyden, Jozef

      2013-03-01

      It has been shown that a suitably built asymmetric microdevice can be used to separate and select self-propelled microorganisms. The efficiency of this rectification effect depends on the detailed dynamics of the individual microorganism. In the case of run-and-tumble bacteria we show that the distribution of run lengths and the partial preservation of run orientation memory through a tumble are important factors when computing the rectification efficiency. In addition, we show that this ratchet effect can be used to separate or concentrate sperm cells. Using a simple phenomenological model we optimize the geometry of the confining habitat in order to accumulate the cells. Both swimming strategy and swimmer size should be taken into account to optimize the design of a micro-patterned architecture for a device that can be used for effective physical bacterial separation or sperm guidance. We acknowledge support from UNC, MINCyT and CONICET, Argentina, and FWO and KUL, Belgium.

    8. Application of the deletion/substitution/addition algorithm to selecting land use regression models for interpolating air pollution measurements in California

      NASA Astrophysics Data System (ADS)

      Beckerman, Bernardo S.; Jerrett, Michael; Martin, Randall V.; van Donkelaar, Aaron; Ross, Zev; Burnett, Richard T.

      2013-10-01

      Land use regression (LUR) models are widely employed in health studies to characterize chronic exposure to air pollution. The LUR is essentially an interpolation technique that employs the pollutant of interest as the dependent variable with proximate land use, traffic, and physical environmental variables used as independent predictors. Two major limitations with this method have not been addressed: (1) variable selection in the model building process, and (2) dealing with unbalanced repeated measures. In this paper, we address these issues with a modeling framework that implements the deletion/substitution/addition (DSA) machine learning algorithm that uses a generalized linear model to average over unbalanced temporal observations. Models were derived for fine particulate matter with aerodynamic diameter of 2.5 microns or less (PM2.5) and nitrogen dioxide (NO2) using monthly observations. We used 4119 observations at 108 sites and 15,301 observations at 138 sites for PM2.5 and NO2, respectively. We derived models with good predictive capacity (cross-validated-R2 values were 0.65 and 0.71 for PM2.5 and NO2, respectively). By addressing these two shortcomings in current approaches to LUR modeling, we have developed a framework that minimizes arbitrary decisions during the model selection process. We have also demonstrated how to integrate temporally unbalanced data in a theoretically sound manner. These developments could have widespread applicability for future LUR modeling efforts.

    9. Beyond Discipline to Guidance: A Primer on the Guidance Alternative.

      ERIC Educational Resources Information Center

      Gartrell, Dan

      As early childhood teachers apply principles of guidance rather than punishment in their classrooms, they face the challenge of avoiding a slippage into traditional discipline practices and transcending the punitive aspects of discipline. Guidance is designed to teach children democratic life skills and therefore goes beyond discipline. Teachers…

    10. Modern control theory for Army missile guidance

      NASA Astrophysics Data System (ADS)

      Travassos, R. H.; Levari, H.; Gupta, N. K.

      1982-11-01

      A Singular perturbation guidance law has been developed for medium-range surface-to-air missiles. This guidance law is a significant extension of a previously developed guidance law for short-range missiles; in medium-range intercepts, the problem of energy management should be addressed in addition to homing guidance. The mathematical formulation has been simplified by introducing separation of time scales. Target Trajectory Estimation: A recursive algorithm for estimation of autoregressive moving average (ARMA) model parameters from noisy samples has been developed. Application of this algorithm to parameter estimation problems has exhibited its fast convergence and unbiasedness in the presence of noise, even with short data records. The algorithm has two versions, a Recursive Maximum Likelihood (RML) form and a Recursive Prediction Error (RPE) form, both of which possess a parallel structure that makes them highly suitable for parallel-processing implementation. Adaptive autopilots: Lattice-form algorithms have been developed for fast, recursive identification and control of time-varying systems. These algorithms have excellent numerical properties and a modular structure that makes them suitable for on-board real-time implementation.

    11. Guidance for an aeroassisted orbital transfer vehicle

      NASA Technical Reports Server (NTRS)

      Hall, Kenneth R.

      1988-01-01

      The use of atmospheric drag for slowing satellite in high energy, high apogee orbits to a lower energy, lower apogee orbit about the Earth is investigated. The high energy orbit is assumed to intercept the Earth's atmosphere. Guidance for the atmospheric phase of the trajectory may be done using the aerodynamic forces generated by the passage through the atmosphere. This research was concerned with the investigation of several methods of guidance during the atmospheric phase to cause a significant reduction in the final velocity as the vehicle leaves the atmosphere. In addition, the velocity direction was controlled to exit to a desired target orbit. Lastly excess aerodynamic lift was used to effect a plane change between the entry orbit plane and the exit orbit plane to achieve a desired orbit plane. The guidance methods were applied to a 3 degree-of-freedom simulation which included an oblate Earth gravity model and a rotating atmosphere. Simulation results were compared on the basis of speed of computation of the guidance parameters and amount of added velocity necessary to achieve the desired orbit.

    12. Endangerment assessment guidance

      SciTech Connect

      Not Available

      1985-11-22

      The directive clarifies the requirement that an endangerment assessment be developed to support all administrative and judicial enforcement actions under Section 106 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and Section 7003 of the Resource Conservation and Recovery Act (RCRA). Before taking enforcement action under these provisions to abate the hazards or potential hazards at a site, the Environmental Protection Agency (EPA) must be able to properly document and justify its assertion that an imminent and substantial endangerment to public health or welfare or the environment may exist. The endangerment assessment provides this documentation and justification. The endangerment assessment is not necessary to support Section 104 actions. It also provides guidance on the content, timing, level of detail, format, and resources required for the preparation of endangerment assessments.

    13. Forced guidance and distribution of practice in sequential information processing.

      NASA Technical Reports Server (NTRS)

      Decker, L. R.; Rogers, C. A., Jr.

      1973-01-01

      Distribution of practice and forced guidance were used in a sequential information-processing task in an attempt to increase the capacity of human information-processing mechanisms. A reaction time index of the psychological refractory period was used as the response measure. Massing of practice lengthened response times while forced guidance shortened them. Interpretation was in terms of load reduction upon the response-selection stage of the information-processing system.-

    14. Advances in spacecraft atmospheric entry guidance

      NASA Astrophysics Data System (ADS)

      Benito Manrique, Joel

      In order to advance entry guidance technology two different research areas have been explored with the objective of increasing the reachable landing area and the landing accuracy for future Mars missions. Currently only the northern hemisphere of Mars is available for landing due to its low elevation. Only low elevation landing sites have the necessary atmospheric density to allow landing using current Entry, Descent and Landing (EDL) technology. In order to reach most of the Ancient Highlands, the majority of the southern hemisphere, advanced EDL technology is needed in multiple fields, including entry guidance. The first research area is the definition and applications of reachable and controllable sets for entry. The definition of the reachable and controllable sets provides a framework for the study of the capabilities of an entry vehicle in a given planet. Reachable and controllable sets can be used to comprehensively characterize the envelope of trajectories that a vehicle can fly, the sites it can reach and the entry states that can be accommodated. The sets can also be used for the evaluation of trajectory planning algorithms and to assist in the selection of the entry or landing sites. In essence, the reachable and controllable sets offer a powerful vehicle and trajectory analysis and design framework that allows for better mission design choices. In order to illustrate the use of the sets, they are computed for a representative Mars mission using two different vehicle configurations. The sets characterize the impact of the vehicle configuration on the entry capability. Furthermore, the sets are used to find the best skip-entry trajectory for a return from the Moon mission, highlighting the utility of the sets in atmospheric maneuvers other than entry. The second research area is the development of the components of an entry guidance algorithm that allow high elevation landing and provide as well high landing accuracy. The approach taken follows the

    15. Guidance for the New Millenium?

      ERIC Educational Resources Information Center

      McLaren, David J.

      1996-01-01

      Reviews the "Guidance Arrangements" consultation document issued with "Higher Still" (proposed new Scottish upper secondary curricula). Argues that the paper ignores the full implications for educational change in Higher Still and misses the opportunity for timely modernization of school guidance. Advocates a cross-curricular model of guidance…

    16. Push drill guidance indication apparatus

      SciTech Connect

      Bockhorst, R.W.; Elenburg, J.H.

      1984-06-05

      The present invention relates to a program controlled apparatus for providing rapid calibration and update of sensor parameters in a push drill guidance apparatus which is remotely controllable from microprocessor circuitry. A special calibration program is set into nonvolatile memory for coaction with the control processor to compute sensor parameters for storage and recall during normal programmed guidance operation.

    17. Guidance in the Secondary School

      ERIC Educational Resources Information Center

      Kumar, V. Jurist Lional

      2010-01-01

      Secondary School Students face a lot of problems in their body as well as in mind due to puberty that tends to adolescence stage. Adolescence has peculiar characters of their own. They need proper Guidance and Counselling to tackle their own problems. Guidance is described as a counselling service to assist the individual in achieving self…

    18. Discussing Diverse Perspectives on Guidance

      ERIC Educational Resources Information Center

      Gonzalez-Mena, Janet; Shareef, Intisar

      2005-01-01

      Ideas about discipline and guidance get extremely complex when they intersect with culture and oppression. Some groups of people who are targets of racism have to protect their children from the oppressive practices of racist individuals and institutions. Their methods of guidance and discipline may be different from those of groups for whom…

    19. Automated Guidance for Student Inquiry

      ERIC Educational Resources Information Center

      Gerard, Libby F.; Ryoo, Kihyun; McElhaney, Kevin W.; Liu, Ou Lydia; Rafferty, Anna N.; Linn, Marcia C.

      2016-01-01

      In 4 classroom experiments we investigated uses for technologies that automatically score student generated essays, concept diagrams, and drawings in inquiry curricula. We used the automatic scores to assign typical and research-based guidance and studied the impact of the guidance on student progress. Seven teachers and their 897 students…

    20. Guidance: Agent of the Counterculture.

      ERIC Educational Resources Information Center

      Patouillet, Raymond A.; Marin, Roselyn L.

      1979-01-01

      This article was an introduction to a convention program presented at the Florida Personnel and Guidance Association Convention (Tampa, Nov., 1977) by Raymond Patouillet, shortly before his sudden death. It encapsulates his guidance philosophy, his understanding of the human condition, and his faith in the crucial role of the caring profession.…

    1. Innovative Approaches to Career Guidance.

      ERIC Educational Resources Information Center

      Freeman, Andrew R.

      A key part of a broad-based approach to career education in Australian schools is vocational/career guidance. Various vocational guidance programs have been developed for specific groups in Australian society, including work experience, caravans, and micrographics technology for the handicapped; pre-employment courses and a family education center…

    2. Marxist Guidance: A Dialectic Lesson

      ERIC Educational Resources Information Center

      Drapela, Victor J.

      1971-01-01

      Based on primary sources published in the Soviet Bloc, this article compares the stated goals of Marxist guidance with actual outcomes, and identifies the foundations of guidance in the Soviet Bloc in terms of Marxist philosophy and social doctrine. Current symptoms of ideological unrest in socialist society as exemplified by the suppressed reform…

    3. Taxonometric Guidance for Developing Quality Assurance

      SciTech Connect

      Thomadsen, Bruce Lin, She-Woei

      2008-05-01

      A taxonomy is an ordered classification system. In error reduction analysis, an examination of the human failures that lead to an event often uses a taxonomy to classify the failures according to some aspect of their characteristics. These classifications provide insights into the forces that kept the persons involved from achieving their intended actions. They also can provide guidance for changing the situation to prevent failure in the future. For example, the corrective action would be different if a therapist pressed the wrong button because several buttons looked alike or they forgot which button to press. Different types of failures lead to particular types of remediation. Taxonomies can provide guidance in selecting between possible corrective actions.

    4. Video guidance, landing, and imaging systems

      NASA Technical Reports Server (NTRS)

      Schappell, R. T.; Knickerbocker, R. L.; Tietz, J. C.; Grant, C.; Rice, R. B.; Moog, R. D.

      1975-01-01

      The adaptive potential of video guidance technology for earth orbital and interplanetary missions was explored. The application of video acquisition, pointing, tracking, and navigation technology was considered to three primary missions: planetary landing, earth resources satellite, and spacecraft rendezvous and docking. It was found that an imaging system can be mechanized to provide a spacecraft or satellite with a considerable amount of adaptability with respect to its environment. It also provides a level of autonomy essential to many future missions and enhances their data gathering ability. The feasibility of an autonomous video guidance system capable of observing a planetary surface during terminal descent and selecting the most acceptable landing site was successfully demonstrated in the laboratory. The techniques developed for acquisition, pointing, and tracking show promise for recognizing and tracking coastlines, rivers, and other constituents of interest. Routines were written and checked for rendezvous, docking, and station-keeping functions.

    5. Signaling from axon guidance receptors.

      PubMed

      Bashaw, Greg J; Klein, Rüdiger

      2010-05-01

      Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental to our understanding of nervous system development and may suggest new strategies to promote axon regeneration after injury or disease. Signaling mechanisms that act downstream of four prominent families of axon guidance cues--netrins, semaphorins, ephrins, and slits--have been extensively studied in both invertebrate and vertebrate model systems. Although details of these signaling mechanisms are still fragmentary and there appears to be considerable diversity in how different guidance receptors regulate the motility of the axonal growth cone, a number of common themes have emerged. Here, we review recent insights into how specific receptors for each of these guidance cues engage downstream regulators of the growth cone cytoskeleton to control axon guidance. PMID:20452961

    6. RH Packaging Program Guidance

      SciTech Connect

      Washington TRU Solutions LLC

      2008-01-12

      The purpose of this program guidance document is to provide the technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package (also known as the "RH-TRU 72-B cask") and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the C of C shall govern. The C of C states: "...each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application." It further states: "...each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the Application." Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M&O) Contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC-approved, users need to be familiar with Title 10 Code of Federal Regulations (CFR) §71.8, "Deliberate Misconduct." Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the U.S. Department of Energy (DOE) Carlsbad Field Office (CBFO) shall be notified immediately. The CBFO will evaluate the issue and notify the NRC if required.In accordance with 10 CFR Part 71, "Packaging and Transportation of Radioactive Material," certificate holders, packaging users, and contractors or subcontractors who use, design, fabricate, test, maintain, or modify the packaging shall post copies of (1) 10 CFR Part 21, "Reporting of Defects and Noncompliance," regulations, (2) Section 206 of the Energy Reorganization Act of 1974, and (3) NRC Form 3, Notice to Employees. These documents must be posted in a

    7. RH Packaging Program Guidance

      SciTech Connect

      Washington TRU Solutions LLC

      2006-11-07

      The purpose of this program guidance document is to provide the technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the C of C shall govern. The C of C states: "...each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application." It further states: "...each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the Application." Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M&O) Contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC-approved, users need to be familiar with 10 Code of Federal Regulations (CFR) §71.8, "Deliberate Misconduct." Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the U.S. Department of Energy (DOE) Carlsbad Field Office (CBFO) shall be notified immediately. CBFO will evaluate the issue and notify the NRC if required. In accordance with 10 CFR Part 71, "Packaging and Transportation of Radioactive Material," certificate holders, packaging users, and contractors or subcontractors who use, design, fabricate, test, maintain, or modify the packaging shall post copies of (1) 10 CFR Part 21, "Reporting of Defects and Noncompliance," regulations, (2) Section 206 of the Energy Reorganization Act of 1974, and (3) NRC Form 3, Notice to Employees. These documents must be posted in a conspicuous location where the activities subject to

    8. Travel guidance system for vehicles

      SciTech Connect

      Takanabe, K.; Yamamoto, M.; Ito, K.; Fujinami, H.

      1987-02-24

      A travel guidance system is described for vehicles including: a heading sensor for detecting a direction of movement of a vehicle; a distance sensor for detecting a distance traveled by the vehicle; a map data storage medium preliminarily storing map data; a control unit for receiving a heading signal from the heading sensor and a distance signal from the distance sensor to successively compute a present position of the vehicle and for generating video signals corresponding to display data including map data from the map data storage medium and data of the present position; and a display having first and second display portions and responsive to the video signals from the control unit to display on the first display portion a map and a present portion mark, in which: the map data storage medium comprises means for preliminarily storing administrative division name data and landmark data; and the control unit comprises: landmark display means for: (1) determining a landmark closest to the present position, (2) causing a position of the landmark to be displayed on the map and (3) retrieving a landmark massage concerning the landmark from the storage medium to cause the display to display the landmark message on the second display portion; division name display means for retrieving the name of an administrative division to which the present position belongs from the storage medium and causing the display to display a division name message on the second display portion; and selection means for selectively actuating at least one of the landmark display means and the division name display means.

    9. Aerocapture Guidance Performance for the Neptune Orbiter

      NASA Technical Reports Server (NTRS)

      Masciarelli, James P.; Westhelle, Carlos H.; Graves, Claude A.

      2004-01-01

      A performance evaluation of the Hybrid Predictor corrector Aerocapture Scheme (HYPAS) guidance algorithm for aerocapture at Neptune is presented in this paper for a Mission to Neptune and the Neptune moon Triton'. This mission has several challenges not experienced in previous aerocapture guidance assessments. These challengers are a very high Neptune arrival speed, atmospheric exit into a high energy orbit about Neptune, and a very high ballistic coefficient that results in a low altitude acceleration capability when combined with the aeroshell LD. The evaluation includes a definition of the entry corridor, a comparison to the theoretical optimum performance, and guidance responses to variations in atmospheric density, aerodynamic coefficients and flight path angle for various vehicle configurations (ballistic numbers). The benefits of utilizing angle-of-attack modulation in addition to bank angle modulation to improve flight performance is also discussed. The results show that despite large sensitivities in apoapsis targeting, the algorithm performs within the allocated AV budget for the Neptune mission bank angle only modulation. The addition of angle-of-attack modulation with as little as 5 degrees of amplitude significantly improves the scatter in final orbit apoapsis. Although the angle-of-attack modulation complicates the vehicle design, the performance enhancement reduces aerocapture risk and reduces the propellant consumption needed to reach the high energy target orbit for a conventional propulsion system.

    10. The Influence of As-Built Surface Conditions on Mechanical Properties of Ti-6Al-4V Additively Manufactured by Selective Electron Beam Melting

      NASA Astrophysics Data System (ADS)

      Sun, Y. Y.; Gulizia, S.; Oh, C. H.; Fraser, D.; Leary, M.; Yang, Y. F.; Qian, M.

      2016-03-01

      Achieving a high surface finish is a major challenge for most current metal additive manufacturing processes. We report the first quantitative study of the influence of as-built surface conditions on the tensile properties of Ti-6Al-4V produced by selective electron beam melting (SEBM) in order to better understand the SEBM process. Tensile ductility was doubled along with noticeable improvements in tensile strengths after surface modification of the SEBM-fabricated Ti-6Al-4V by chemical etching. The fracture surfaces of tensile specimens with different surface conditions were characterised and correlated with the tensile properties obtained. The removal of a 650- μm-thick surface layer by chemical etching was shown to be necessary to eliminate the detrimental influence of surface defects on mechanical properties. The experimental results and analyses underline the necessity to modify the surfaces of SEBM-fabricated components for structural applications, particularly for those components which contain complex internal concave and convex surfaces and channels.

    11. Modeling the Microstructure Evolution During Additive Manufacturing of Ti6Al4V: A Comparison Between Electron Beam Melting and Selective Laser Melting

      NASA Astrophysics Data System (ADS)

      Vastola, G.; Zhang, G.; Pei, Q. X.; Zhang, Y.-W.

      2016-05-01

      Beam-based additive manufacturing (AM) is an innovative technique in which parts are built layerwise, starting from the material in powder form. As a developing manufacturing technique, achievement of excellent mechanical properties in the final part is of paramount importance for the mainstream adoption of this technique in industrial manufacturing lines. At the same time, AM offers an unprecedented opportunity to precisely control the manufacturing conditions locally within the part during build, enabling local influence on the formation of the texture and microstructure. In order to achieve the control of microstructure by tailoring the AM machine parameters, a full understanding and modeling of the heat transfer and microstructure evolution processes is needed. Here, we show the implementation of the non-equilibrium equations for phase formation and dissolution in an AM modeling framework. The model is developed for the Ti6Al4V alloy and allows us to show microstructure evolution as given by the AM process. The developed capability is applied to the cases of electron beam melting and selective laser melting AM techniques to explain the significantly different microstructures observed in the two processes.

    12. Selective Laser Melting Additive Manufacturing of TiC/AlSi10Mg Bulk-form Nanocomposites with Tailored Microstructures and Properties

      NASA Astrophysics Data System (ADS)

      Gu, Dongdong; Wang, Hongqiao; Chang, Fei; Dai, Donghua; Yuan, Pengpeng; Hagedorn, Yves-Christian; Meiners, Wilhelm

      The nanoscale TiC particle reinforced AlSi10Mg nanocomposite parts were produced by selective laser melting (SLM) additive manufacturing process. The influence of laser energy density (LED) on densification behavior, microstructural evolution, microhardness and wear properties of SLM-processed TiC/AlSi10Mg nanocomposites was studied. It showed that the near fully dense nanocomposite parts (>98% theoretical density) were achieved with increasing the applied LED. The TiC reinforcement in SLM-processed parts experienced a microstructural change from the standard nanoscale particle morphology (the average size 77-93 nm) to the relatively coarsened submicron structure (the mean particle size 154 nm) as the LED increased.The sufficiently high densification rate combined with the homogeneousdistribution of nanoscale TiC reinforcement throughout the matrix led to a high microhardness of 181.2 HV0.2, a considerably low coefficient of friction (COF) of 0.36, and a reduced wear rate of 2.94×10-5 mm3N-1m-1 for SLM-processed TiC/AlSi10Mg nanocomposite parts.

    13. A Honeycomb-Structured Ti-6Al-4V Oil-Gas Separation Rotor Additively Manufactured by Selective Electron Beam Melting for Aero-engine Applications

      NASA Astrophysics Data System (ADS)

      Tang, H. P.; Wang, Q. B.; Yang, G. Y.; Gu, J.; Liu, N.; Jia, L.; Qian, M.

      2016-03-01

      Oil -gas separation is a key process in an aero-engine lubrication system. This study reports an innovative development in oil -gas separation. A honeycomb-structured rotor with hexagonal cone-shaped pore channels has been designed, additively manufactured from Ti-6Al-4V using selective electron beam melting (SEBM) and assessed for oil -gas separation for aero-engine application. The Ti-6Al-4V honeycomb structure showed a high compressive strength of 110 MPa compared to less than 20 MPa for metal foam structures. The oil -gas separation efficiency of the honeycomb-structured separation rotor achieved 99.8% at the rotation speed of 6000 rpm with much lower ventilation resistance (17.3 kPa) than that of the separator rotor constructed using a Ni-Cr alloy foam structure (23.5 kPa). The honeycomb-structured Ti-6Al-4V separator rotor produced by SEBM provides a promising solution to more efficient oil -gas separation in the aero-engine lubrication system.

    14. Peacekeeper - Guidance system flight readiness review

      NASA Astrophysics Data System (ADS)

      Knight, D. S.; Harrington, E. V.

      The Ballistic Missile Office (BMO) has developed and employed a procedure to insure the flight readiness of a Peacekeeper guidance system. The goals of this additional review procedure (over and above acceptance testing) are to minimize the risk of the guidance system failure and/or achieving substantially less than the designed accuracy. The roles, mission and interaction of teams of personnel from seven associate contractors are discussed using flow diagrams. The paper also includes methods used to identify and resolve areas of concern as well as examples of actual concerns discovered. The scope is discused, including both the various technical disciplines involved and the lowest level of build and test areas reviewed. Resulting build and test improvements are shown.

    15. RH Packaging Program Guidance

      SciTech Connect

      Washington TRU Solutions, LLC

      2003-08-25

      The purpose of this program guidance document is to provide technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the SARP and/or C of C shall govern. The C of C states: ''...each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, ''Operating Procedures,'' of the application.'' It further states: ''...each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, ''Acceptance Tests and Maintenance Program of the Application.'' Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M&O) contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC approved, users need to be familiar with 10 CFR {section} 71.11, ''Deliberate Misconduct.'' Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the Carlsbad Field Office (CBFO) shall be notified immediately. CBFO will evaluate the issue and notify the NRC if required. This document details the instructions to be followed to operate, maintain, and test the RH-TRU 72-B packaging. This Program Guidance standardizes instructions for all users. Users shall follow these instructions. Following these instructions assures that operations are safe and meet the requirements of the SARP. This document is available on the Internet at: ttp://www.ws/library/t2omi/t2omi.htm. Users are responsible for ensuring they are using the current revision and change notices. Sites may prepare their own document using the word

    16. Video guidance sensor

      NASA Technical Reports Server (NTRS)

      Howard, Richard

      1991-01-01

      A Martin-Marietta study comparing the application of laser, video, or RF sensors was conducted in 1982. The study concluded that video was the most attractive sensor (the video also could be used for operator monitoring). The Retro-Reflector field Tracker from the Solar Array Flight Experiment was chosen as a 'first generation' sensor and integrated with guidance algorithms for evaluation on the air-bearing vehicle. Results indicated that this sensor was not applicable for the noise environment posed by the multi-layer insulation used on most spacecraft. A 'second generation' sensor was developed to be used with a modified RMS target. This sensor utilized two sets of laser diodes to acquire three optically filtered targets. The targets were illuminated first with a 780 nanometer diode, followed by illumination with a 830 nm diode. The second digitized picture was subtracted from the first to get a low-noise image. The centroids of the retroreflectors were used then to uniquely derive target attitude and range. The sensor presently operates to 80 feet and within +/- 40 degrees in pitch and yaw. Sensor operability is a concern if the sun is within a +/- 40 degree cone angle to the target. The present sensor performance characteristics are less than 1 percent range error and less than 1 degree angle error. Future sensor development is anticipated to extend the operating range to 150 feet and reduce the cone angle of sensor inoperability to within +/- 10 degrees of direct sunlight. Performance improvements also are anticipated. TRW currently is developing a system that utilizes dual cameras with simultaneous diode illumination. Although further development is being pursued, the basic system has proven sound, and the sensor is essentially ready for application.

    17. Effect of build geometry on the β-grain structure and texture in additive manufacture of Ti-6Al-4V by selective electron beam melting

      SciTech Connect

      Antonysamy, A.A.; Meyer, J.; Prangnell, P.B.

      2013-10-15

      With titanium alloys, the solidification conditions in Additive Manufacturing (AM) frequently lead to coarse columnar β-grain structures. The effect of geometry on the variability in the grain structure and texture, seen in Ti-6Al-4V alloy components produced by Selective Electron Beam Melting (SEBM), has been investigated. Reconstruction of the primary β-phase, from α-phase EBSD data, has confirmed that in bulk sections where in-fill “hatching” is employed growth selection favours columnar grains aligned with an <001> {sub β} direction normal to the deposited powder layers; this results in a coarse β-grain structure with a strong < 001 > {sub β} fibre texture (up 8 x random) that can oscillate between a near random distribution around the fibre axis and cube reinforcement with build height. It is proposed that this behaviour is related to the highly elongated melt pool and the raster directions alternating between two orthogonal directions every layer, which on average favours grains with cube alignment. In contrast, the outline, or “contour”, pass produces a distinctly different grain structure and texture resulting in a skin layer on wall surfaces, where nucleation occurs off the surrounding powder and growth follows the curved surface of the melt pool. This structure becomes increasingly important in thin sections. Local heterogeneities have also been found within different section transitions, resulting from the growth of skin grain structures into thicker sections. Texture simulations have shown that the far weaker α-texture (∼ 3 x random), seen in the final product, arises from transformation on cooling occurring with a near random distribution of α-plates across the 12 variants possible from the Burgers relationship. - Highlights: • Distinctly different skin and bulk structures are produced by the contour and hatching passes. • Bulk sections contain coarse β-grains with a < 001 > fibre texture in the build direction. • This

    18. GUIDANCE DOCUMENT ON ENVIRONMENTAL MODELS

      EPA Science Inventory

      This guidance provides recommendations intended to assist in the development, evaluation and application of high quality environmental models that the Environmental Protection Agency uses to address environmental problems and to support regulatory activities. These guidelines wi...

    19. The influence of Citrosept addition to drinking water and Scutellaria baicalensis root extract on the content of selected mineral elements in the blood plasma of turkey hens.

      PubMed

      Rusinek-Prystupa, Elżbieta; Lechowski, Jerzy; Zukiewicz-Sobczak, Wioletta; Sobczak, Paweł; Zawiślak, Kazimierz

      2014-01-01

      The aim of this research work was to indicate the influence of Citrosept preparation and Scutellaria baicalensis root extract, administered per os to growing turkey hens in 3 different dosages, on the content of selected mineral elements in blood plasma of slaughter turkey hens. An attempt was also made to specify the most effective dosage of the applied preparations with the highest efficiency as regards increased levels of examined macro- and microelements in the birds' blood. The research experiment was conducted on 315 turkey hens randomly divided into seven groups, each consisting of 45 turkey hens. Group K constituted the control group without experimental additions of the above-mentioned preparations. When it comes to turkey hens which belonged to groups II-IV, Citrosept preparation was instilled to water in the following dosages: Group II - 0.011 ml/kg of bm; Group III - 0.021 ml/kg of bm; Group IV - 0.042 ml/kg bm. For birds which belonged to groups V-VII preparation, which was Scutellaria baicalensis root extract, was instilled to water in the following dosages: Group V - 0.009 ml/kg of bm; Group VI - 0.018 ml/kg of bm, Group VII - 0.036 ml/kg bm. In the examined plant extracts and blood plasma of the birds the levels of Na, K, Ca, Mg, Cu, Zn, and Fe were identified. The use of examined extracts influenced the changes in the levels of all tested elements in slaughter turkey hens' blood plasma. An upward tendency was recorded which regarded the level of calcium and magnesium, and a downward tendency of sodium, potassium, copper, zinc, and iron in relation to the results achieved in the control group. PMID:25292136

    20. Developing guidance for budget impact analysis.

      PubMed

      Trueman, P; Drummond, M; Hutton, J

      2001-01-01

      The role of economic evaluation in the efficient allocation of healthcare resources has been widely debated. Whilst economic evidence is undoubtedly useful to purchasers, it does not address the issue of affordability which is an increasing concern. Healthcare purchasers are concerned not just with maximising efficiency but also with the more simplistic goal of remaining within their annual budgets. These two objectives are not necessarily consistent. This paper examines the issue of affordability, the relationship between affordability and efficiency and builds the case for why there is a growing need for budget impact models to complement economic evaluation. Guidance currently available for such models is also examined and it is concluded that this guidance is currently insufficient. Some of these insufficiencies are addressed and some thoughts on what constitutes best practice in budget impact modelling are suggested. These suggestions include consideration of transparency, clarity of perspective, reliability of data sources, the relationship between intermediate and final end-points and rates of adoption of new therapies. They also include the impact of intervention by population subgroups or indications, reporting of results, probability of re-deploying resources, the time horizon, exploring uncertainty and sensitivity analysis, and decision-maker access to the model. Due to the nature of budget impact models, the paper does not deliver stringent methodological guidance on modelling. The intention was to provide some suggestions of best practice in addition to some foundations upon which future research can build. PMID:11456210

    1. Precision visual guidance for agricultural applicator aircraft

      NASA Astrophysics Data System (ADS)

      Hartt, Joseph R.; Bletzacker, Frank R.; Forgette, T. J.; Vetter, Alan A.

      1992-07-01

      The in-cockpit swath centerline identifier (SCI) for aerial applicators uses differentially corrected global positioning system (GPS) signals to determine precise ground track of an aircraft and provide guidance to the pilot for flying patterns for aerial application of materials such as pesticides, herbicides, and fertilizers. Cross track distance from the swath centerline is provided by a heads up light bar display while detailed navigation, position, and status information is provided on an alphanumeric display on a panel mounted console. This system provides straight line guidance when executing a swath and turn-in guidance when proceeding from one swath to the next. It provides a record of the swaths which were sprayed and logs all of the associated navigation and operational data, including time. In addition, it provides navigation information from base to the fields, between fields, and return. The SCI eliminates the need for flaggers while providing improved accuracy of application. Reduced exposure to liability and improved quality control results as the position, altitude, time, and spray status are logged for post flight analysis. The SCI has been used in commercial agricultural applications. Demonstrations of the SCI showed better precision than anticipated.

    2. Information Paper 18: Guidance in Secondary Schools.

      ERIC Educational Resources Information Center

      Ashton, Terry

      1986-01-01

      Traces impetus for introduction of structured guidance into Scottish secondary schools. Identifies 1968 "Orange Paper" as first attempt to set out rationale for guidance. Describes how guidance is organized; outlines tasks of guidance teachers; and presents current developments, training requirements, and trends. (NEC)

    3. Books for Professionals: Discipline and Guidance.

      ERIC Educational Resources Information Center

      King, Margaret A.

      1994-01-01

      Reviews two books that promote a view of discipline as teaching and guidance. "Guiding Young Children" (Verna Hildebrand) offers specific child guidance techniques and a discussion of general issues affecting child guidance. "Constructive Guidance and Discipline: Preschool and Primary Education" (Majorie V. Fields and Cindy Boesser) focuses on…

    4. Measuring Client Progression in Adult Guidance

      ERIC Educational Resources Information Center

      Hearne, Lucy

      2007-01-01

      Currently, in the field of guidance, relevant stakeholders including guidance practitioners, educators and policy makers, have identified progression for adults in education and employment as one of the key outcomes of educational guidance. Lifelong guidance is now inextricably linked with lifelong learning as a mechanism to enhance individual…

    5. Effects of selected feed additives on the performance of laying hens given a diet rich in maize dried distiller's grains with solubles (DDGS).

      PubMed

      Świątkiewicz, S; Arczewska-Włosek, A; Krawczyk, J; Puchała, M; Józefiak, D

      2013-01-01

      1. A total of 192 ISA Brown hens were given diets containing a high concentration of maize dried distiller's grains with solubles (DDGS) and the effect of selected feed additives on laying performance and egg quality was determined. 2. Birds were allocated to 8 treatment groups with 12 replicates (cages) of two hens and were given, from week 26 to 55, iso-caloric and iso-nitrogenous experimental diets with or without a high concentration of DDGS (200 g/kg). The diet containing DDGS was not supplemented or supplemented with enzymes (xylanase and phytase), sodium butyrate, probiotic bacteria (Lactobacillus salivarius) and a mixture of herbal extracts (Taraxaci siccum, Urticae siccum and Salviae siccum), inulin or chitosan. 3. The inclusion of DDGS in the diet had no effect on number of eggs produced, total egg mass, mean egg weight, feed intake or feed conversion ratio. Egg and eggshell quality parameters were also unaffected by dietary DDGS. The yolk colour score (points in Roche scale) was significantly increased by DDGS inclusion. DDGS in the diet caused some changes in the yolk lipid profile that were rather unfavourable from a dietary perspective (an increase of cholesterol content, and PUFA n-6/PUFA n-3 ratio). 4. During the experimental period (26-55 weeks of age) supplementation of the diet containing a high concentration of DDGS with enzymes, inulin as well as chitosan, increased number of eggs produced and daily egg mass. In older hens (50 weeks of age) inulin positively affected eggshell quality parameters, i.e. shell percentage, thickness and density. Diet supplementation with herb extracts, inulin or chitosan, decreased the content of cholesterol in yolks. 5. The results of this study suggest that DDGS may be incorporated up to a concentration of 200 g/kg in the diet of laying hens without any negative effects on egg performance. Moreover, supplementation of xylanase and phytase, as well as inulin and chitosan, can positively affect the performance of

    6. Selective Ni-P electroless plating on photopatterned cationic adsorption films influenced by alkyl chain lengths of polyelectrolyte adsorbates and additive surfactants.

      PubMed

      Nakagawa, Masaru; Nawa, Nozomi; Iyoda, Tomokazu

      2004-10-26

      We demonstrated that the photopatterned single-layer adsorption film of poly(1-dodecyl-4-pyridinium bromide) on a silica surface was available for a template of nickel-phosphorus (Ni-P) electroless plating through sensitization with a SnCl(2) aqueous solution and activation with a PdCl(2) aqueous solution. Four kinds of poly(1-alkyl-4-vinylpyridinium halide)s bearing methyl, propyl, hexyl, and dodecyl groups were prepared. The cationic polymers were adsorbed by a negatively charged silica surface from their solutions, to form single-layer adsorption films exhibiting desorption-resistance toward deionized water and ethanol. The organic adsorption films could be decomposed completely by exposure to 172 nm deep-UV light. The formation and decomposition of the single-layer films were confirmed by deep-UV absorption spectral measurement and zeta-potential measurement. Ni-P electroless plating was carried out on the photopatterned adsorption films, using three types of SnO(x) colloidal materials without and with cationic or anionic surfactant as catalyst precursors in the sensitization step. In the case of the negatively charged SnO(x) colloids surrounded by anionic surfactant, Ni-deposition took place preferentially on the cationic adsorption films remaining in unexposed regions. The Ni-deposition was accelerated significantly on the cationic adsorption film bearing dodecyl groups. It was obvious by ICP-AES analyses that the hydrophobic long-chain dodecyl groups in the adsorption film could promote the adsorption of the negative SnO(x) colloids on the film surface, followed by much nucleus formation of zerovalent Pd catalysts useful for the electroless plating. The result of our experiment clearly showed that, in addition to electrostatic interaction, van der Waals interaction generating between the hydrophobic long-chain hydrocarbons of the adsorption film and the surfactant improved significantly the adsorption stability of the SnO(x) colloids, resulting in highly

    7. 78 FR 48201 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2013-01; Guidance for...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-08-07

      ... guidance prior to its issuance formally for public comment. On April 25, 2013 (78 FR 24439), the NRC... tsunami wave inundated the site, followed by additional waves. The tsunami caused extensive damage to site... needed in the areas of seismic and flooding design and emergency preparedness. In addition to...

    8. Food additives

      MedlinePlus

      Food additives are substances that become part of a food product when they are added during the processing or making of that food. "Direct" food additives are often added during processing to: Add nutrients ...

    9. Radon Reduction Techniques in Schools: Interim Technical Guidance.

      ERIC Educational Resources Information Center

      Environmental Protection Agency, Washington, DC.

      This technical document is intended to assist school facilities maintenance personnel in the selection, design, and operation of radon reduction systems in schools. The guidance contained in this document is based largely on research conducted in 1987 and 1988 in schools located in Maryland and Virginia. Researchers from the United States…

    10. Applications of Kelly's Personal Construct Theory to Vocational Guidance

      ERIC Educational Resources Information Center

      Paszkowska-Rogacz, Anna; Kabzinska, Zofia

      2012-01-01

      This paper outlines selected applications of Kelly's Personal Construct Theory to vocational guidance. The authors elicited personal constructs using the Rep Test (Role Construct Repertory Test) and compared them with Holland's occupational typology. The sample (N = 136, F = 85, M = 51, average age of 21.97) was composed of students of various…

    11. College Counselors' Perceptions and Practices regarding Anticipatory Guidance on Firearms

      ERIC Educational Resources Information Center

      Price, James; Mrdjenovich, Adam J.; Thompson, Amy; Dake, Joseph A.

      2009-01-01

      Objectives: This study assessed college counselors' anticipatory guidance on firearms for student clients. Participants: The membership of the Association for University and College Counseling Center Directors was used to identify a national random sample of counseling centers (n = 361). One counselor from each center was selected to survey.…

    12. TRAINING INSTITUTE FOR VOCATIONAL GUIDANCE AND COUNSELING PERSONNEL.

      ERIC Educational Resources Information Center

      WELLMAN, FRANK E.

      A MULTIDISCIPLINARY TRAINING INSTITUTE WAS PROVIDED FOR A SELECT GROUP OF 40 STATE AND LOCAL VOCATIONAL GUIDANCE AND COUNSELING PERSONNEL EMPLOYED IN LEADERSHIP POSITIONS. THE DESIGN OF THE INSTITUTE EMPHASIZED THE DEVELOPMENT OF UNDERSTANDINGS, KNOWLEDGES, AND PROFESSIONAL MATERIALS RELATED TO (1) ECONOMIC FACTORS INFLUENCING VOCATIONAL EDUCATION…

    13. Cultural Patterns of Metacognitive Guidance in Australian Homes

      ERIC Educational Resources Information Center

      Sanagavarapu, Prathyusha

      2008-01-01

      This article provides insight into the cultural patterns of metacognitive guidance that occurs among children and mothers in selected Australian homes. Fourteen Anglo Australian and eight immigrant Indian (Telugu) mothers' interactions with their 4-year-old male and female children on a puzzle-solving task were videotaped. Mother-child dyads'…

    14. GUIDANCE MANUAL ON OVERTOPPING CONTROL TECHNIQUES FOR HAZARDOUS WASTE IMPOUNDMENTS

      EPA Science Inventory

      The overall objective of the project was to provide guidance for selecting cost-effective interim management methods to control overtopping of impoundments, pits, ponds, or lagoons at uncontrolled hazardous waste sites until final remedial actions could be initiated. Hazardous wa...

    15. Information architecture. Volume 3: Guidance

      SciTech Connect

      1997-04-01

      The purpose of this document, as presented in Volume 1, The Foundations, is to assist the Department of Energy (DOE) in developing and promulgating information architecture guidance. This guidance is aimed at increasing the development of information architecture as a Departmentwide management best practice. This document describes departmental information architecture principles and minimum design characteristics for systems and infrastructures within the DOE Information Architecture Conceptual Model, and establishes a Departmentwide standards-based architecture program. The publication of this document fulfills the commitment to address guiding principles, promote standard architectural practices, and provide technical guidance. This document guides the transition from the baseline or defacto Departmental architecture through approved information management program plans and budgets to the future vision architecture. This document also represents another major step toward establishing a well-organized, logical foundation for the DOE information architecture.

    16. Autonomous Guidance, Navigation and Control

      NASA Technical Reports Server (NTRS)

      Bordano, A. J.; Mcswain, G. G.; Fernandes, S. T.

      1991-01-01

      The NASA Autonomous Guidance, Navigation and Control (GN&C) Bridging program is reviewed to demonstrate the program plan and GN&C systems for the Space Shuttle. The ascent CN&C system is described in terms of elements such as the general-purpose digital computers, sensors for the navigation subsystem, the guidance-system software, and the flight-control subsystem. Balloon-based and lidar wind soundings are used for operations assessment on the day of launch, and the guidance software is based on dedicated units for atmospheric powered flight, vacuum powered flight, and abort-specific situations. Optimization of the flight trajectories is discussed, and flight-control responses are illustrated for wavelengths of 500-6000 m. Alternate sensors are used for load relief, and adaptive GN&C systems based on alternate gain synthesis are used for systems failures.

    17. Science, Eighth Year - Resource Material for Teachers. Career Guidance Series 1967-68.

      ERIC Educational Resources Information Center

      Anker, Irving; Lloyd, Helene M.

      This resource guide contains practical suggestions for teaching of Grade 8 science to the pupils in the Career Guidance Program. The Career Guidance Program was developed for students who are over-age, frustrated, retarded in the school subject, and indifferent to education. The selection and organization of the material parallels the regular…

    18. 78 FR 32667 - Draft Guidance for Industry on Rheumatoid Arthritis: Developing Drug Products for Treatment...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-05-31

      ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled ``Rheumatoid Arthritis: Developing Drug Products for Treatment.'' This guidance outlines FDA's current thinking on the principles of clinical development relevant to dose-selection and assessment of efficacy and safety to support the approval of drug products for the treatment of......

    19. Optimal sliding guidance algorithm for Mars powered descent phase

      NASA Astrophysics Data System (ADS)

      Wibben, Daniel R.; Furfaro, Roberto

      2016-02-01

      Landing on large planetary bodies (e.g. Mars) with pinpoint accuracy presents a set of new challenges that must be addressed. One such challenge is the development of new guidance algorithms that exhibit a higher degree of robustness and flexibility. In this paper, the Zero-Effort-Miss/Zero-Effort-Velocity (ZEM/ZEV) optimal sliding guidance (OSG) scheme is applied to the Mars powered descent phase. This guidance algorithm has been specifically designed to combine techniques from both optimal and sliding control theories to generate an acceleration command based purely on the current estimated spacecraft state and desired final target state. Consequently, OSG yields closed-loop trajectories that do not need a reference trajectory. The guidance algorithm has its roots in the generalized ZEM/ZEV feedback guidance and its mathematical equations are naturally derived by defining a non-linear sliding surface as a function of the terms Zero-Effort-Miss and Zero-Effort-Velocity. With the addition of the sliding mode and using Lyapunov theory for non-autonomous systems, one can formally prove that the developed OSG law is globally finite-time stable to unknown but bounded perturbations. Here, the focus is on comparing the generalized ZEM/ZEV feedback guidance with the OSG law to explicitly demonstrate the benefits of the sliding mode augmentation. Results show that the sliding guidance provides a more robust solution in off-nominal scenarios while providing similar fuel consumption when compared to the non-sliding guidance command. Further, a Monte Carlo analysis is performed to examine the performance of the OSG law under perturbed conditions.

    20. Food additives

      PubMed Central

      Spencer, Michael

      1974-01-01

      Food additives are discussed from the food technology point of view. The reasons for their use are summarized: (1) to protect food from chemical and microbiological attack; (2) to even out seasonal supplies; (3) to improve their eating quality; (4) to improve their nutritional value. The various types of food additives are considered, e.g. colours, flavours, emulsifiers, bread and flour additives, preservatives, and nutritional additives. The paper concludes with consideration of those circumstances in which the use of additives is (a) justified and (b) unjustified. PMID:4467857

    1. Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance

      PubMed Central

      Oster, S F; Sretavan, D W

      2003-01-01

      In the past several years, a great deal has been learnt about the molecular basis through which specific neural pathways in the visual system are established during embryonic development. This review provides a framework for understanding the principles of retinal ganglion cell axon guidance, and introduces some of the families of axon guidance molecules involved. In addition, the potential relevance of retinal axon guidance to human visual developmental disorders, and to retinal axon regeneration, is discussed. PMID:12714414

    2. 20 CFR 901.72 - Additional rules.

      Code of Federal Regulations, 2011 CFR

      2011-04-01

      ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Additional rules. 901.72 Section 901.72... Additional rules. The Joint Board may, in notice or other guidance of general applicability, provide additional rules regarding the enrollment of actuaries. Effective Date Note: At 76 FR 17776, Mar. 31,...

    3. Humanizing Education Through Guidance Counseling.

      ERIC Educational Resources Information Center

      Accola, W. V.

      A computerized information retrieval system has been designed to support the secondary school counseling effort. The system, entitled Total Guidance Information Support System (TGISS), runs on an IBM System/360 Model 65 facility and uses the IBM 2848 Display Control Unit. The software consists of an interactive communications program developed in…

    4. THE STRESSOR IDENTIFICATION GUIDANCE DOCUMENT

      EPA Science Inventory

      THE STRESSOR IDENTIFICATION GUIDANCE DOCUMENT

      Susan M. Cormier, ORD/NRMRL, Susan B. Norton, ORD/NCEA, Glenn W. Suter, II ORD/NCEA, William Swietlik, OW lOST

      Science Question(s):

      MYP Science Question: How can multiple and possibly related causes of biological ...

    5. Reading Guidance: Death and Grief.

      ERIC Educational Resources Information Center

      Smith, Alice Gullen

      1989-01-01

      Gives guidelines for the librarian using reading guidance (similar to bibliotherapy). Provides a nine-item annotated bibliography of novels for children and adolescents on the subject of death and grief. Appends an embryo list of categories suitable for content analysis of any file librarians might wish to keep on books suitable for use in this…

    6. Career Guidance in Singapore Schools.

      ERIC Educational Resources Information Center

      Tan, Esther

      2002-01-01

      Reviews the history and stages of development for career guidance in Singapore schools. Asserts that to meet the challenges of the new millennium, there is a need to train professional career counselors, develop indigenous resource materials, and promote a new concept of career development among students. (Contains 15 references.) (GCP)

    7. Developing Local Lifelong Guidance Strategies.

      ERIC Educational Resources Information Center

      Watts, A. G.; Hawthorn, Ruth; Hoffbrand, Jill; Jackson, Heather; Spurling, Andrea

      1997-01-01

      Outlines the background, rationale, methodology, and outcomes of developing local lifelong guidance strategies in four geographic areas. Analyzes the main components of the strategies developed and addresses a number of issues relating to the process of strategy development. Explores implications for parallel work in other localities. (RJM)

    8. DOE Waste Treatability Group Guidance

      SciTech Connect

      Kirkpatrick, T.D.

      1995-01-01

      This guidance presents a method and definitions for aggregating U.S. Department of Energy (DOE) waste into streams and treatability groups based on characteristic parameters that influence waste management technology needs. Adaptable to all DOE waste types (i.e., radioactive waste, hazardous waste, mixed waste, sanitary waste), the guidance establishes categories and definitions that reflect variations within the radiological, matrix (e.g., bulk physical/chemical form), and regulated contaminant characteristics of DOE waste. Beginning at the waste container level, the guidance presents a logical approach to implementing the characteristic parameter categories as part of the basis for defining waste streams and as the sole basis for assigning streams to treatability groups. Implementation of this guidance at each DOE site will facilitate the development of technically defined, site-specific waste stream data sets to support waste management planning and reporting activities. Consistent implementation at all of the sites will enable aggregation of the site-specific waste stream data sets into comparable national data sets to support these activities at a DOE complex-wide level.

    9. A new paradigm in optimal missile guidance

      NASA Astrophysics Data System (ADS)

      Morgan, Robert W.

      2007-12-01

      This dissertation investigates advanced concepts in terminal missile guidance. The terminal phase of missile guidance usually lasts less than ten seconds and calls for very accurate maneuvering to ensure intercept. Technological advancements have produced increasingly sophisticated threats that greatly reduce the effectiveness of traditional approaches to missile guidance. Because of this, terminal missile guidance is, and will remain, an important and active area of research. The complexity of the problem and the desire for an optimal solution has resulted in researchers focusing on simplistic, usually linear, models. The fruit of these endeavors has resulted in some of the world's most advanced weapons systems. Even so, the resulting guidance schemes cannot possibly counter the evolving threats that will push the system outside the linear envelope for which they were designed. The research done in this dissertation greatly extends previous research in the area of optimal missile guidance. Herein it is shown that optimal missile guidance is fundamentally a pairing of an optimal guidance strategy and an optimal control strategy. The optimal guidance strategy is determined from a missile's information constraints, which are themselves largely determined from the missile's sensors. The optimal control strategy is determined by the missile's control constraints, and works to achieve a specified guidance strategy. This dichotomy of missile guidance is demonstrated by showing that missiles having different control constraints utilize the same guidance strategy so long as the information constraints are the same. This concept has hitherto been unrecognized because of the difficulty in developing an optimal control for the nonlinear set of equations that result from control constraints. Having overcome this difficulty by indirect means, evidence of the guidance strategy paradigm emerged. The guidance strategy paradigm is used to develop two advanced guidance laws. The new

    10. High spectrum selectivity and enhanced responsivity of a ZnO ultraviolet photodetector realized by the addition of ZnO nanoparticles layer.

      PubMed

      Yu, Ji; Tian, Ning

      2016-08-24

      A photodetector with a high spectrum selectivity and enhanced responsivity has been realized in the ZnO NPs coated Au/ZnO/Au structure. In this structure, the ZnO NPs act as the "filter" that filtrates out the short-wavelength photons to ensure the high spectrum selectivity of the photodetector, whereas on the other hand they act as the "scatterer" to scatter incident light in order to increase the absorption of the ZnO film and consequently enhance the responsivity of the photodetector. In this way, a photodetector with a response width of only 10 nm has been obtained, and the responsivity of the photodetector is 0.052 A W(-1) at 3 V at the wavelength of 376 nm, which is higher than that of the bare Au/ZnO/Au structured photodetector (0.028 A W(-1)). The results reported in this paper may provide a facile route to a highly spectrum-selective photodetector without performance degradation. PMID:27526634

    11. Haptic Guidance Needs to Be Intuitive Not Just Informative to Improve Human Motor Accuracy

      PubMed Central

      Mugge, Winfred; Kuling, Irene A.; Brenner, Eli; Smeets, Jeroen B. J.

      2016-01-01

      Humans make both random and systematic errors when reproducing learned movements. Intuitive haptic guidance that assists one to make the movements reduces such errors. Our study examined whether any additional haptic information about the location of the target reduces errors in a position reproduction task, or whether the haptic guidance needs to be assistive to do so. Holding a haptic device, subjects made reaches to visible targets without time constraints. They did so in a no-guidance condition, and in guidance conditions in which the direction of the force with respect to the target differed, but the force scaled with the distance to the target in the same way. We examined whether guidance forces directed towards the target would reduce subjects’ errors in reproducing a prior position to the same extent as do forces rotated by 90 degrees or 180 degrees, as it might because the forces provide the same information in all three cases. Without vision of the arm, both the accuracy and precision were significantly better with guidance directed towards the target than in all other conditions. The errors with rotated guidance did not differ from those without guidance. Not surprisingly, the movements tended to be faster when guidance forces directed the reaches to the target. This study shows that haptic guidance significantly improved motor performance when using it was intuitive, while non-intuitively presented information did not lead to any improvements and seemed to be ignored even in our simple paradigm with static targets and no time constraints. PMID:26982481

    12. Highly Effective Photonic Cue for Repulsive Axonal Guidance

      PubMed Central

      Black, Bryan J.; Gu, Ling; Mohanty, Samarendra K.

      2014-01-01

      In vivo nerve repair requires not only the ability to regenerate damaged axons, but most importantly, the ability to guide developing or regenerating axons along paths that will result in functional connections. Furthermore, basic studies in neuroscience and neuro-electronic interface design require the ability to construct in vitro neural circuitry. Both these applications require the development of a noninvasive, highly effective tool for axonal growth-cone guidance. To date, a myriad of technologies have been introduced based on chemical, electrical, mechanical, and hybrid approaches (such as electro-chemical, optofluidic flow and photo-chemical methods). These methods are either lacking in desired spatial and temporal selectivity or require the introduction of invasive external factors. Within the last fifteen years however, several attractive guidance cues have been developed using purely light based cues to achieve axonal guidance. Here, we report a novel, purely optical repulsive guidance technique that uses low power, near infrared light, and demonstrates the guidance of primary goldfish retinal ganglion cell axons through turns of up to 120 degrees and over distances of ∼90 µm. PMID:24717339

    13. Highly effective photonic cue for repulsive axonal guidance.

      PubMed

      Black, Bryan J; Gu, Ling; Mohanty, Samarendra K

      2014-01-01

      In vivo nerve repair requires not only the ability to regenerate damaged axons, but most importantly, the ability to guide developing or regenerating axons along paths that will result in functional connections. Furthermore, basic studies in neuroscience and neuro-electronic interface design require the ability to construct in vitro neural circuitry. Both these applications require the development of a noninvasive, highly effective tool for axonal growth-cone guidance. To date, a myriad of technologies have been introduced based on chemical, electrical, mechanical, and hybrid approaches (such as electro-chemical, optofluidic flow and photo-chemical methods). These methods are either lacking in desired spatial and temporal selectivity or require the introduction of invasive external factors. Within the last fifteen years however, several attractive guidance cues have been developed using purely light based cues to achieve axonal guidance. Here, we report a novel, purely optical repulsive guidance technique that uses low power, near infrared light, and demonstrates the guidance of primary goldfish retinal ganglion cell axons through turns of up to 120 degrees and over distances of ∼90 µm. PMID:24717339

    14. A Self Assessment and Program Guidance Instrument for Use in Physical Education Programs.

      ERIC Educational Resources Information Center

      Soares, Patricia; Trimble, Tom

      1983-01-01

      The Self Assessment-Program Guidance instrument aids students in selecting relevant courses of study in physical education. The instrument, which is presented and discussed, includes eight assessment and activity categories. (JMK)

    15. GUIDANCE ON FEASIBILITY STUDIES UNDER CERCLA (COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION AND LIABILITY ACT)

      EPA Science Inventory

      This guidance document is intended to provide a more detailed structure for identifying, evaluating, and selecting remedial action alternatives under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Contingency Plan (40 CFR 300)....

    16. 76 FR 75771 - Emergency Planning Guidance for Nuclear Power Plants

      Federal Register 2010, 2011, 2012, 2013, 2014

      2011-12-05

      ... Utilization Facilities'' that were published as a final rule in the Federal Register (FR) on November 23, 2011 (76 FR 72560). Additional guidance on one topic not directly related to the EP final rule (i.e... rule discussed that rule's compliance with applicable backfitting provisions (76 FR 72560; November...

    17. School Guidance Counselors' Perceptions of Actual and Preferred Job Duties

      ERIC Educational Resources Information Center

      Edwards, John Dexter

      2010-01-01

      The purpose of this study was to provide process data for school counselors, administrators, and the public, regarding school counselors' actual roles within the guidance counselor preferred job duties and actual job duties. In addition, factors including National Certification or no National Certification, years of counseling experience, and…

    18. Engineering Guidance: A Human Resource Development.

      ERIC Educational Resources Information Center

      Snarponis, Joseph M.; Prien, John D.

      1979-01-01

      Describes the role of The National Society of Professional Engineers (NSPE) in providing guidance activities for students. Discusses structional organization, goals, and guidance activities for engineering and technical and professional societies. (MA)

    19. Activity Group Guidance: A Developmental Approach

      ERIC Educational Resources Information Center

      Hillman, Bill W.; And Others

      1975-01-01

      Illustrates the content, process, and group dynamics of Activity Group Guidance. Describes and evaluates a comprehensive Activity Group Guidance program. Gives specific suggestions to counselors who wish to start Activity Groups. (Author)

    20. Hands-On Parent Support in Positive Guidance: Early Childhood Professionals as Mentors

      ERIC Educational Resources Information Center

      McFarland-Piazza, Laura; Saunders, Rachel

      2012-01-01

      This study reports findings from a follow-up study involving mothers and early childhood professionals who completed participation in a 12-week, hands-on parent education program in the United States. In this program, mothers learned about positive guidance in a weekly seminar, and additionally practised implementing positive guidance in an early…

    1. Comparison of ISO 9000 and recent software life cycle standards to nuclear regulatory review guidance

      SciTech Connect

      Preckshot, G.G.; Scott, J.A.

      1998-01-20

      Lawrence Livermore National Laboratory is assisting the Nuclear Regulatory Commission with the assessment of certain quality and software life cycle standards to determine whether additional guidance for the U.S. nuclear regulatory context should be derived from the standards. This report describes the nature of the standards and compares the guidance of the standards to that of the recently updated Standard Review Plan.

    2. 75 FR 70011 - Guidance for Industry, Mammography Quality Standards Act Inspectors, and Food and Drug...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2010-11-16

      ...The Food and Drug Administration (FDA) is announcing the availability of the guidance entitled ``The Mammography Quality Standards Act Final Regulations: Modifications and Additions to Policy Guidance Help System 13.'' This document is intended to assist mammography facilities and their personnel in meeting the requirements of the Mammography Quality Standards Act (MQSA)...

    3. Food additives.

      PubMed

      Berglund, F

      1978-01-01

      The use of additives to food fulfils many purposes, as shown by the index issued by the Codex Committee on Food Additives: Acids, bases and salts; Preservatives, Antioxidants and antioxidant synergists; Anticaking agents; Colours; Emulfifiers; Thickening agents; Flour-treatment agents; Extraction solvents; Carrier solvents; Flavours (synthetic); Flavour enhancers; Non-nutritive sweeteners; Processing aids; Enzyme preparations. Many additives occur naturally in foods, but this does not exclude toxicity at higher levels. Some food additives are nutrients, or even essential nutritents, e.g. NaCl. Examples are known of food additives causing toxicity in man even when used according to regulations, e.g. cobalt in beer. In other instances, poisoning has been due to carry-over, e.g. by nitrate in cheese whey - when used for artificial feed for infants. Poisonings also occur as the result of the permitted substance being added at too high levels, by accident or carelessness, e.g. nitrite in fish. Finally, there are examples of hypersensitivity to food additives, e.g. to tartrazine and other food colours. The toxicological evaluation, based on animal feeding studies, may be complicated by impurities, e.g. orthotoluene-sulfonamide in saccharin; by transformation or disappearance of the additive in food processing in storage, e.g. bisulfite in raisins; by reaction products with food constituents, e.g. formation of ethylurethane from diethyl pyrocarbonate; by metabolic transformation products, e.g. formation in the gut of cyclohexylamine from cyclamate. Metabolic end products may differ in experimental animals and in man: guanylic acid and inosinic acid are metabolized to allantoin in the rat but to uric acid in man. The magnitude of the safety margin in man of the Acceptable Daily Intake (ADI) is not identical to the "safety factor" used when calculating the ADI. The symptoms of Chinese Restaurant Syndrome, although not hazardous, furthermore illustrate that the whole ADI

    4. Guidance manual for managing transportation planning data. Final report

      SciTech Connect

      1997-12-31

      This guidance manual contains procedures for identifying, collecting, organizing, and using data for transportation planning purposes. Specific discussions are included on strategic assessments of data needs; a framework for organizing data, cost effectiveness of data, and the integration and consistency of data. The guidance contained herein will be of interest to planners in state departments of transportation (DOTs) and metropolitan planning organizations (MPOs). Two additional project reports are available on the Internet`s World Wide Web: the agency`s (1) Final Report and (2) Compendium of Data Collection Practices and Sources.

    5. Gut Health of Pigs: Challenge Models and Response Criteria with a Critical Analysis of the Effectiveness of Selected Feed Additives — A Review

      PubMed Central

      Adewole, D. I.; Kim, I. H.; Nyachoti, C. M.

      2016-01-01

      The gut is the largest organ that helps with the immune function. Gut health, especially in young pigs has a significant benefit to health and performance. In an attempt to maintain and enhance intestinal health in pigs and improve productivity in the absence of in-feed antibiotics, researchers have evaluated a wide range of feed additives. Some of these additives such as zinc oxide, copper sulphate, egg yolk antibodies, mannan-oligosaccharides and spray dried porcine plasma and their effectiveness are discussed in this review. One approach to evaluate the effectiveness of these additives in vivo is to use an appropriate disease challenge model. Over the years, researchers have used a number of challenge models which include the use of specific strains of enterotoxigenic Escherichia coli, bacteria lipopolysaccharide challenge, oral challenge with Salmonella enteric serotype Typhimurium, sanitation challenge, and Lawsonia intercellularis challenge. These challenge models together with the criteria used to evaluate the responses of the animals to them are also discussed in this review. PMID:26954144

    6. Gut Health of Pigs: Challenge Models and Response Criteria with a Critical Analysis of the Effectiveness of Selected Feed Additives - A Review.

      PubMed

      Adewole, D I; Kim, I H; Nyachoti, C M

      2016-07-01

      The gut is the largest organ that helps with the immune function. Gut health, especially in young pigs has a significant benefit to health and performance. In an attempt to maintain and enhance intestinal health in pigs and improve productivity in the absence of in-feed antibiotics, researchers have evaluated a wide range of feed additives. Some of these additives such as zinc oxide, copper sulphate, egg yolk antibodies, mannan-oligosaccharides and spray dried porcine plasma and their effectiveness are discussed in this review. One approach to evaluate the effectiveness of these additives in vivo is to use an appropriate disease challenge model. Over the years, researchers have used a number of challenge models which include the use of specific strains of enterotoxigenic Escherichia coli, bacteria lipopolysaccharide challenge, oral challenge with Salmonella enteric serotype Typhimurium, sanitation challenge, and Lawsonia intercellularis challenge. These challenge models together with the criteria used to evaluate the responses of the animals to them are also discussed in this review. PMID:26954144

    7. Quality Assurance in University Guidance Services

      ERIC Educational Resources Information Center

      Simon, Alexandra

      2014-01-01

      In Europe there is no common quality assurance framework for the delivery of guidance in higher education. Using a case study approach in four university career guidance services in England, France and Spain, this article aims to study how quality is implemented in university career guidance services in terms of strategy, standards and models,…

    8. Idaho Comprehensive Guidance and Counseling Program Model.

      ERIC Educational Resources Information Center

      Idaho State Dept. of Education, Boise.

      This handbook describes a series of procedures for establishing school guidance and counseling programs in Idaho based on the Missouri Comprehensive Guidance Program model developed by Dr. Norman Gysbers. It begins with a conceptual framework and moves through the development, evaluation, and refinement steps of setting guidance programs in Idaho…

    9. Computer-Assisted Guidance: Concepts and Practices.

      ERIC Educational Resources Information Center

      Katz, Martin R.; Shatkin, Laurence

      This report reviews and analyzes the development and status of computer-assisted-guidance (CAG) systems. In terms of eight major topics which are introduced in a discussion of guidance and the computer, the report discusses the capabilities of computers in reference to other resources for guidance and describes and differentiates various CAG…

    10. Assessment of Relative Velocity as Independent Variable for Space Shuttle First Stage Guidance Attitude Command Tables

      NASA Technical Reports Server (NTRS)

      Kimbrough, M.

      1977-01-01

      The selection of relative velocity as the independent variable for the space shuttle first stage guidance attitude command tables was assessed to support the first stage guidance point design. The criterion for selecting the independent variable for first stage open loop guidance is to reduce or minimize performance dispersions, primarily those affecting structural loads. The products of angle of attack and angle of sideslip times dynamic pressure are used as load indicators, and minimizing their dispersions will indicate a minimum loads dispersion. Relative velocity is shown to be an acceptable steering independent variable.

    11. Optical guidance vidicon test program

      NASA Technical Reports Server (NTRS)

      Eiseman, A. R.; Stanton, R. H.; Voge, C. C.

      1976-01-01

      A laboratory and field test program was conducted to quantify the optical navigation parameters of the Mariner vidicons. A scene simulator and a camera were designed and built for vidicon tests under a wide variety of conditions. Laboratory tests characterized error sources important to the optical navigation process and field tests verified star sensitivity and characterized comet optical guidance parameters. The equipment, tests and data reduction techniques used are described. Key test results are listed. A substantial increase in the understanding of the use of selenium vidicons as detectors for spacecraft optical guidance was achieved, indicating a reduction in residual offset errors by a factor of two to four to the single pixel level.

    12. Microfluidic control of axonal guidance

      NASA Astrophysics Data System (ADS)

      Gu, Ling; Black, Bryan; Ordonez, Simon; Mondal, Argha; Jain, Ankur; Mohanty, Samarendra

      2014-10-01

      The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may directly affect neuronal guidance during early organ development. Here, we report direct evidence of fluid flow influencing axonal migration, producing turning angles of up to 90°. Microfluidic flow simulations indicate that an axon may experience significant bending force due to cross-flow, which may contribute to the observed axonal turning. This method of flow-based guidance was successfully used to fasciculate one advancing axon onto another, showcasing the potential of this technique to be used for the formation of in vitro neuronal circuits.

    13. Teleautonomous guidance for mobile robots

      NASA Technical Reports Server (NTRS)

      Borenstein, J.; Koren, Y.

      1990-01-01

      Teleautonomous guidance (TG), a technique for the remote guidance of fast mobile robots, has been developed and implemented. With TG, the mobile robot follows the general direction prescribed by an operator. However, if the robot encounters an obstacle, it autonomously avoids collision with that obstacle while trying to match the prescribed direction as closely as possible. This type of shared control is completely transparent and transfers control between teleoperation and autonomous obstacle avoidance gradually. TG allows the operator to steer vehicles and robots at high speeds and in cluttered environments, even without visual contact. TG is based on the virtual force field (VFF) method, which was developed earlier for autonomous obstacle avoidance. The VFF method is especially suited to the accommodation of inaccurate sensor data (such as that produced by ultrasonic sensors) and sensor fusion, and allows the mobile robot to travel quickly without stopping for obstacles.

    14. National Environmental Policy Act guidance: A model process

      SciTech Connect

      Angle, B.M.; Lockhart, V.A.T.; Sema, B.; Tuott, L.C.; Irving, J.S.

      1995-04-01

      The ``Model National Environmental Policy Act (NEPA) Process`` includes: References to regulations, guidance documents, and plans; training programs; procedures; and computer databases. Legislative Acts and reference documents from Congress, US Department of Energy, and Lockheed Idaho Technologies Company provide the bases for conducting NEPA at the Idaho National Engineering Laboratory (INEL). Lockheed Idaho Technologies Company (LITCO) NEPA / Permitting Department, the Contractor Environmental Organization (CEO) is responsible for developing and maintaining LITCO NEPA and permitting policies, guidance, and procedures. The CEO develops procedures to conduct environmental evaluations based on NEPA, Council on Environmental Quality (CEQ) regulations, and DOE guidance. This procedure includes preparation or support of environmental checklists, categorical exclusion determinations, environmental assessment determinations, environmental assessments, and environmental impact statements. In addition, the CEO uses this information to train personnel conducting environmental evaluations at the INEL. Streamlining these procedures fosters efficient use of resources, quality documents, and better decisions on proposed actions.

    15. Mars Science Laboratory Entry Guidance

      NASA Technical Reports Server (NTRS)

      Mendeck, Gavin F.

      2011-01-01

      The Mars Science Laboratory will be the first Mars mission to attempt a guided entry with the objective of safely delivering the entry vehicle to a survivable parachute deploy state within 12.5 km of the pre-designated parachute deploy coordinates. The Entry Terminal Point Controller guidance algorithm is derived from the final phase Apollo Command Module guidance and, like Apollo, modulates the bank angle to control range based on deviations in range, altitude rate, and drag acceleration from a reference trajectory. For application to Mars landers which must make use of the tenuous Martian atmosphere, it is critical to balance the lift of the vehicle to minimize the range while still ensuring a safe deploy altitude. An overview of the process to generate optimized guidance settings is presented, discussing improvements made over the last nine years. Performance tradeoffs between ellipse size and deploy altitude will be presented, along with imposed constraints of entry acceleration and heating. Performance sensitivities to the bank reversal deadbands, heading alignment, attitude initialization error, and entry delivery errors are presented.

    16. Studies on the effects of essential-oil-based feed additives on performance, ileal nutrient digestibility, and selected bacterial groups in the gastrointestinal tract of piglets.

      PubMed

      Maenner, K; Vahjen, W; Simon, O

      2011-07-01

      The aim of this study was to assess the effects of 2 different phytogenic products on performance, ileal nutrient digestibility, and composition of the intestinal microbiota. The 2 phytogenic products contained different essential oil mixtures (EOM) characterized by either menthol (Mentha arvensis; EOM-M) or cinnamon aldehyde (Cinnamomum aromaticum; EOM-C) as main constituents. Three treatments consisted of control diet without EOM addition and diets supplemented with EOM-M or EOM-C. Reproducibility of the effects was examined in 4 trials with a total of 300 male castrated and female piglets weaned at 25 d of age. The number of pens per treatment in trials I through III were 7, 9, and 9, respectively, for research station conditions, and 10 in trial IV for simulated farm conditions. In research station conditions, the experimental unit consisted of flat deck pens with 2 piglets per pen, whereas it consisted of floor pens with straw bedding with 5 piglets per pen in farm conditions. The feed additives had no effect on feed intake or BW gain. Improvements (P < 0.05) in G:F were observed for EOM-M supplemented diets in 2 of 4 trials as well as for the combined data of all trials. These improvements were associated with greater (P<0.05) apparent ileal digestibility of CP and of most AA. The effect of EOM-C on these response criteria was intermediate between control and EOM-M. Real-time PCR analysis of the gastrointestinal contents for 7 bacterial groups (Lactobacillus spp., Enterococcus spp., Clostridium coccoides and Clostridium leptum cluster, Escherichia spp., and Escherichia coli toxin estII) indicated no effect of treatments on the gastrointestinal microbiota. It was concluded that EOM-M consistently improved feed efficiency in weaned piglets, and it was associated with improved ileal protein and AA digestibility. In general, however, the effectiveness of EOM as feed additives differs considerably depending on the constituents. PMID:21357448

    17. [Psychotherapeutically Competent Child Guidance-General Framework and Legal Foundations].

      PubMed

      Menne, Klaus

      2015-01-01

      Assistances in education are pedagogical and therapeutic benefits connected with it. For child guidance as an assistance in education therefore psychotherapeutic competence is constitutive. The article describes the professional and legal framework of a psychotherapy in child guidance. It specifies on the one hand the composition of the multi disciplinary team (including child and youth psychotherapists and psychological psychotherapists) and the additional therapeutic qualifications acquired by the skilled employees. On the other hand it traces the judicial border between a medical psychotherapy with its scientifically recognised psychotherapy procedures and methods and a psychotherapy in child guidance. The applicability of the new law on the rights of patients with its requirements on a contract governing medical treatment (standards of medical specialists, duty to provide information, information provided for self-determination as well as documentation) on child guidance is discussed as well. The author argues for the preservation of psychotherapeutic competence in child guidance as a benefit sui generis and sees precisely in its therapeutic competence its specific contribution to the advancement of the assistances in education. PMID:25609390

    18. Evidence-Based Background Material Underlying Guidance for Federal Agencies in Implementing Strategic Sustainability Performance Plans - Implementing Sustainability: The Institutional-Behavioral Dimension

      SciTech Connect

      Malone, Elizabeth L.; Sanquist, Tom; Wolfe, Amy K.; Diamond, Rick; Payne, Christopher; Dion, Jerry

      2013-06-01

      This document is part of a larger, programmatic effort to assist federal agencies in taking action and changing their institutions to achieve and maintain federal sustainability goals, while meeting their mission goals. FEMP is developing guidance for federal agency efforts to enable institutional behavior change for sustainability, and for making sustainability “business as usual.” The driving requirement for this change is Executive Order (EO) 13514, Federal Leadership in Environmental, Energy, and Economic Performance. FEMP emphasizes strategies for increasing energy efficiency and renewable energy utilization as critical components of attaining sustainability, and promotes additional non-energy action pathways contained in EO 13514. This report contributes to the larger goal by laying out the conceptual and evidentiary underpinnings of guidance to federal agencies. Conceptual frameworks focus and organize the development of guidance. We outline a series of progressively refined conceptual frameworks, including a multi-layer approach, key steps in sustainability implementation, a process view of specific approaches to institutional change, the agency Strategic Sustainability Performance Plans (SSPPs), and concepts related to context-specific rules, roles and tools for sustainability. Additionally, we tap pertinent bodies of literature in drawing eight evidence-based principles for behavior change. These principles are important foundations upon which to build in selecting strategies to effect change in organizations. Taken together, this report presents a suite of components that inform the training materials, presentations, web site, and other products that provide guidance to federal agencies.

    19. Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions

      PubMed Central

      Peniche, Alex G.; Renslo, Adam R.; Melby, Peter C.

      2015-01-01

      Current treatments for cutaneous and visceral leishmaniasis are toxic, expensive, difficult to administer, and limited in efficacy and availability. Disulfiram has primarily been used to treat alcoholism. More recently, it has shown some efficacy as therapy against protozoan pathogens and certain cancers, suggesting a wide range of biological activities. We used an ex vivo system to screen several thiuram disulfide compounds for antileishmanial activity. We found five compounds (compound identifier [CID] 7188, 5455, 95876, 12892, and 3117 [disulfiram]) with anti-Leishmania activity at nanomolar concentrations. We further evaluated these compounds with the addition of divalent metal salts based on studies that indicated these salts could potentiate the action of disulfiram. In addition, clinical studies suggested that zinc has some efficacy in treating cutaneous leishmaniasis. Several divalent metal salts were evaluated at 1 μM, which is lower than the normal levels of copper and zinc in plasma of healthy individuals. The leishmanicidal activity of disulfiram and CID 7188 were enhanced by several divalent metal salts at 1 μM. The in vitro therapeutic index (IVTI) of disulfiram and CID 7188 increased 12- and 2.3-fold, respectively, against L. major when combined with ZnCl2. The combination of disulfiram with ZnSO4 resulted in a 1.8-fold increase in IVTI against L. donovani. This novel combination of thiuram disulfides and divalent metal ions salts could have application as topical and/or oral therapies for treatment of cutaneous and visceral leishmaniasis. PMID:26239994

    20. Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions.

      PubMed

      Peniche, Alex G; Renslo, Adam R; Melby, Peter C; Travi, Bruno L

      2015-10-01

      Current treatments for cutaneous and visceral leishmaniasis are toxic, expensive, difficult to administer, and limited in efficacy and availability. Disulfiram has primarily been used to treat alcoholism. More recently, it has shown some efficacy as therapy against protozoan pathogens and certain cancers, suggesting a wide range of biological activities. We used an ex vivo system to screen several thiuram disulfide compounds for antileishmanial activity. We found five compounds (compound identifier [CID] 7188, 5455, 95876, 12892, and 3117 [disulfiram]) with anti-Leishmania activity at nanomolar concentrations. We further evaluated these compounds with the addition of divalent metal salts based on studies that indicated these salts could potentiate the action of disulfiram. In addition, clinical studies suggested that zinc has some efficacy in treating cutaneous leishmaniasis. Several divalent metal salts were evaluated at 1 μM, which is lower than the normal levels of copper and zinc in plasma of healthy individuals. The leishmanicidal activity of disulfiram and CID 7188 were enhanced by several divalent metal salts at 1 μM. The in vitro therapeutic index (IVTI) of disulfiram and CID 7188 increased 12- and 2.3-fold, respectively, against L. major when combined with ZnCl2. The combination of disulfiram with ZnSO4 resulted in a 1.8-fold increase in IVTI against L. donovani. This novel combination of thiuram disulfides and divalent metal ions salts could have application as topical and/or oral therapies for treatment of cutaneous and visceral leishmaniasis. PMID:26239994

    1. Irreversible Wash Aid Additive for Cesium Mitigation: Phase II. Selection and/or Modification of COTS Field Portable Waste Water Systems

      SciTech Connect

      Kaminski, Michael; Mertz, Carol; Kivenas, Nadia; Magnuson, Matthew

      2015-01-01

      After an accidental or malicious release of radioactivity, large urban areas may be contaminated, compromising response efforts by first responders and law enforcement officials. In addition, some public services (e.g., drinking water and wastewater treatment, electrical power distribution, etc.) may be disrupted. In such an event, it may be important to deploy mitigation efforts in certain areas to restore response activities and public services (Fig. S-1). This report explores the state-of-the-art approach for a system to rapidly return critical infrastructure components to service following a cesium-137 (Cs-137) radiological dispersal device (RDD) release while avoiding the spread of Cs-137 beyond its original deposition area and minimizing the amount of Cs-137-contaminated wastewater. Specifically, we describe a wash system consisting of chemical additives added to fire hydrant water and irreversible solid sequestering agents added as the water is collected and treated for recycle in situ. The wash system is intended to be a rapidly deployable, cost-effective means of mitigating an urban setting for the purpose of restoring critical infrastructure and operational activities after a radiological release.

    2. EPA guidance on improving the image of psychiatry.

      PubMed

      Möller-Leimkühler, A M; Möller, H-J; Maier, W; Gaebel, W; Falkai, P

      2016-03-01

      This paper explores causes, explanations and consequences of the negative image of psychiatry and develops recommendations for improvement. It is primarily based on a WPA guidance paper on how to combat the stigmatization of psychiatry and psychiatrists and a Medline search on related publications since 2010. Furthermore, focussing on potential causes and explanations, the authors performed a selective literature search regarding additional image-related issues such as mental health literacy and diagnostic and treatment issues. Underestimation of psychiatry results from both unjustified prejudices of the general public, mass media and healthcare professionals and psychiatry's own unfavourable coping with external and internal concerns. Issues related to unjustified devaluation of psychiatry include overestimation of coercion, associative stigma, lack of public knowledge, need to simplify complex mental issues, problem of the continuum between normality and psychopathology, competition with medical and non-medical disciplines and psychopharmacological treatment. Issues related to psychiatry's own contribution to being underestimated include lack of a clear professional identity, lack of biomarkers supporting clinical diagnoses, limited consensus about best treatment options, lack of collaboration with other medical disciplines and low recruitment rates among medical students. Recommendations are proposed for creating and representing a positive self-concept with different components. The negative image of psychiatry is not only due to unfavourable communication with the media, but is basically a problem of self-conceptualization. Much can be improved. However, psychiatry will remain a profession with an exceptional position among the medical disciplines, which should be seen as its specific strength. PMID:26874959

    3. Potlining Additives

      SciTech Connect

      Rudolf Keller

      2004-08-10

      In this project, a concept to improve the performance of aluminum production cells by introducing potlining additives was examined and tested. Boron oxide was added to cathode blocks, and titanium was dissolved in the metal pool; this resulted in the formation of titanium diboride and caused the molten aluminum to wet the carbonaceous cathode surface. Such wetting reportedly leads to operational improvements and extended cell life. In addition, boron oxide suppresses cyanide formation. This final report presents and discusses the results of this project. Substantial economic benefits for the practical implementation of the technology are projected, especially for modern cells with graphitized blocks. For example, with an energy savings of about 5% and an increase in pot life from 1500 to 2500 days, a cost savings of $ 0.023 per pound of aluminum produced is projected for a 200 kA pot.

    4. Optical technologies for intraoperative neurosurgical guidance.

      PubMed

      Valdés, Pablo A; Roberts, David W; Lu, Fa-Ke; PhD; Golby, Alexandra

      2016-03-01

      Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering, biophysics, computer science, medicine, biology, and chemistry, helping us understand light-tissue interactions to create applications with diagnostic and therapeutic value in medicine. Implementation of biomedical optics tools and principles has had a notable scientific and clinical resurgence in recent years in the neurosurgical community. This is in great part due to work in fluorescence-guided surgery of brain tumors leading to reports of significant improvement in maximizing the rates of gross-total resection. Multiple additional optical technologies have been implemented clinically, including diffuse reflectance spectroscopy and imaging, optical coherence tomography, Raman spectroscopy and imaging, and advanced quantitative methods, including quantitative fluorescence and lifetime imaging. Here we present a clinically relevant and technologically informed overview and discussion of some of the major clinical implementations of optical technologies as intraoperative guidance tools in neurosurgery. PMID:26926066

    5. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia.

      PubMed

      Chen, Jing; Pise-Masison, Cynthia A; Shih, Joanna H; Morris, John C; Janik, John E; Conlon, Kevin C; Keating, Anne; Waldmann, Thomas A

      2013-03-14

      Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4(+)CD25(+) lymphocytes caused by human T-cell lymphotropic virus type 1. Currently, there is no accepted curative therapy for ATL. In gene expression profiling, the antiapoptotic protein survivin (BIRC5) demonstrated a striking increase in ATL, and its expression was increased in patient ATL cells resistant to the anti-CD52 monoclonal antibody alemtuzumab (Campath-1H). In this study, we investigated the antitumor activity of a small-molecule survivin suppressant YM155 alone and in combination with alemtuzumab in a murine model of human ATL (MET-1). Both YM155 alone and its combination with alemtuzumab demonstrated therapeutic efficacy by lowering serum soluble IL-2Rα (sIL-2Rα) levels (P < .001) and prolonged the survival of tumor-bearing mice (P < .0001). Moreover, the combination of YM155 with alemtuzumab demonstrated markedly additive antitumor activity by significantly lowering serum sIL-2Rα levels and improving the survival of leukemia-bearing mice compared with monotherapy with either YM155 (P < .001) or alemtuzumab (P < .05). More significantly, all mice that received the combination therapy survived and were tumor free >6 months after treatment. Our data support a clinical trial of the combination of YM155 with alemtuzumab in ATL. This trial was registered at www.clinicaltrials.gov as #NCT00061048. PMID:23321252

    6. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia

      PubMed Central

      Chen, Jing; Pise-Masison, Cynthia A.; Shih, Joanna H.; Morris, John C.; Janik, John E.; Conlon, Kevin C.; Keating, Anne

      2013-01-01

      Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4+CD25+ lymphocytes caused by human T-cell lymphotropic virus type 1. Currently, there is no accepted curative therapy for ATL. In gene expression profiling, the antiapoptotic protein survivin (BIRC5) demonstrated a striking increase in ATL, and its expression was increased in patient ATL cells resistant to the anti-CD52 monoclonal antibody alemtuzumab (Campath-1H). In this study, we investigated the antitumor activity of a small-molecule survivin suppressant YM155 alone and in combination with alemtuzumab in a murine model of human ATL (MET-1). Both YM155 alone and its combination with alemtuzumab demonstrated therapeutic efficacy by lowering serum soluble IL-2Rα (sIL-2Rα) levels (P < .001) and prolonged the survival of tumor-bearing mice (P < .0001). Moreover, the combination of YM155 with alemtuzumab demonstrated markedly additive antitumor activity by significantly lowering serum sIL-2Rα levels and improving the survival of leukemia-bearing mice compared with monotherapy with either YM155 (P < .001) or alemtuzumab (P < .05). More significantly, all mice that received the combination therapy survived and were tumor free >6 months after treatment. Our data support a clinical trial of the combination of YM155 with alemtuzumab in ATL. This trial was registered at www.clinicaltrials.gov as #NCT00061048. PMID:23321252

    7. Determination of fluorine and chlorine in geological materials by induction furnace pyrohydrolysis and standard-addition ion-selective electrode measurement.

      PubMed

      Rice, T D

      1988-03-01

      Fluorine and chlorine in geological materials are volatilized by pyrohydrolysis at about 1150 degrees in a stream of oxygen (1000 ml/min) plus steam in an induction furnace. The catalyst is a 7:2:1 mixture of silica gel, tungstic oxide and potassium dihydrogen phosphate. The sample/catalyst mixture is pyrohydrolysed in a re-usable alumina crucible (already containing four drops of 1 + 3 phosphoric acid) inserted in a silica-enclosed graphite crucible. The absorption solution is buffered at pH 6.5 and spiked with 1.6 mug of fluoride and 16 mug of chloride per g of solution, to ensure rapid and linear electrode response during subsequent standard-addition measurement. The simple plastic absorption vessel has 99.5% efficiency. The 3s limits of detection are 5-10 mug/g and 40-100 mug/g for fluorine and chlorine respectively. The procedure is unsuitable for determining chlorine in coal. PMID:18964490

    8. Exploring the Use of Individualized, Reflective Guidance In an Educational Multi-User Virtual Environment

      NASA Astrophysics Data System (ADS)

      Nelson, Brian C.

      2007-02-01

      This study examines the patterns of use and potential impact of individualized, reflective guidance in an educational Multi-User Virtual Environment (MUVE). A guidance system embedded within a MUVE-based scientific inquiry curriculum was implemented with a sample of middle school students in an exploratory study investigating (a) whether access to the guidance system was associated with improved learning, (b) whether students viewing more guidance messages saw greater improvement on content tests than those viewing less, and (c) whether there were any differences in guidance use among boys and girls. Initial experimental findings showed that basic access to individualized guidance used with a MUVE had no measurable impact on learning. However, post-hoc exploratory analyses indicated that increased use of the system among those with access to it was positively associated with content test score gains. In addition, differences were found in overall learning outcomes by gender and in patterns of guidance use by boys and girls, with girls outperforming boys across a spectrum of guidance system use. Based on these exploratory findings, the paper suggests design guidelines for the development of guidance systems embedded in MUVEs and outlines directions for further research.

    9. Isotope dilution-GC-MS/MS analysis of 16 polycyclic aromatic hydrocarbons in selected medicinal herbs used as health food additives.

      PubMed

      Yu, L; Cao, Y; Zhang, J; Cui, Z; Sun, H

      2012-01-01

      Medicinal herbs have a very important role in health protection and disease control, and have been used in health foods. Polycyclic aromatic hydrocarbons (PAHs) have carcinogenic, biological and mutagenic effects. In this paper, the content of 16 PAHs as representative contaminants in nine Chinese medicinal herbs, as additives for health foods, was investigated in order to ensure food safety from this source. A highly sensitive isotope dilution-gas chromatography-tandem mass spectrometry (ID-GC-MS/MS) method combined with gel permeation chromatography (GPC) and solid-phase extraction (SPE) was developed. Calibration curves showed good linearity for all PAHs (R² > 0.999), and the limit of quantification (LOQ) ranged from 0.42 to 2.7 µg kg⁻¹. Average recoveries for these compounds were in the range of 52.5-117%, 52.6-119% and 81.4-108% at the concentrations of 10, 50 and 250 µg kg⁻¹ with RSD of 1.8-15%, 0.9-15% and 1.0-15%, respectively. The proposed method was used for the analysis of nine Chinese medicinal herbs. Total levels of PAHs varied from 98.2 µg kg⁻¹ (cassia seed) to 2245 µg kg⁻¹ (eucommia bark). The highest level was found for phenanthrene (Phe) in liquorice root (631.3 µg kg⁻¹), indigowoad leaf (551.0 µg kg⁻¹), rose flower (435.2 µg kg⁻¹) and eucommia bark (432.3 µg kg⁻¹). The proposed method could provide a useful basis for safety monitoring of herbs and risk management for PAHs in the health food industry. PMID:22870881

    10. Video Guidance, Landing, and Imaging system (VGLIS) for space missions

      NASA Technical Reports Server (NTRS)

      Schappell, R. T.; Knickerbocker, R. L.; Tietz, J. C.; Grant, C.; Flemming, J. C.

      1975-01-01

      The feasibility of an autonomous video guidance system that is capable of observing a planetary surface during terminal descent and selecting the most acceptable landing site was demonstrated. The system was breadboarded and "flown" on a physical simulator consisting of a control panel and monitor, a dynamic simulator, and a PDP-9 computer. The breadboard VGLIS consisted of an image dissector camera and the appropriate processing logic. Results are reported.

    11. A discrete adaptive guidance system for a roving vehicle

      NASA Technical Reports Server (NTRS)

      Miller, J. A.

      1977-01-01

      An adaptive guidance technique which provides a self-correcting path following capability in an environment sensitive semi-autonomous roving robot is described. A real-time maneuver planning function performs tradeoffs between speed, magnitude of expected deviations and accelerations to best satisfy the design goals of vehicle safety and reliability, subsystem autonomy, performance accuracy and operational efficiency. The appropriate combination of maneuver parameters is selected through an iterative process using knowledge of vehicle performance characteristics, environmental model updates and vehicle state

    12. An Optimal Guidance Law Applied to Quadrotor Using LQR Method

      NASA Astrophysics Data System (ADS)

      Jafari, Hamidreza; Zareh, Mehran; Roshanian, Jafar; Nikkhah, Amirali

      The optimal guidance law of an autonomous four-rotor helicopter, called the Quadrotor, using linear quadratic regulators (LQR) is presented in this paper. The dynamic equations of the Quadrotor are considered nonlinear so to find an LQR controller, it is necessary that these equations be linearized in different operation points. Due to importance of energy consumption in Quadrotors, minimum energy is selected as the optimal criteria.

    13. Total System Performance Assessment-License Application Design Selection (LADS) Phase 1 Analysis of Surface Modification Consisting of Addition of Alluvium (Feature 23a)

      SciTech Connect

      N. Erb

      1999-06-11

      The objective of this report is to document the analysis that was conducted to evaluate the effect of a potential change to the TSPA-VA base case design that could improve long-term repository performance. The design feature evaluated in this report is a modification of the topographic surface of Yucca Mountain. The modification consists of covering the land surface immediately above the repository foot-print with a thick layer of unconsolidated material utilizing rip-rap and plants to mitigate erosion. This surface modification is designated as Feature 23a or simply abbreviated as F23a. The fundamental aim of F23a is to reduce the net infiltration into the unsaturated zone by enhancing the potential for evapotranspiratiration at the surface; such a change would, in turn, reduce the seepage flux and the rate of radionuclide releases from the repository. Field and modeling studies of water movement in the unsaturated zone have indicated that shallow infiltration at the surface is almost negligible in locations where the bedrock is covered by a sufficiently thick soil layer. In addition to providing storage for meteoric water, a thick soil layer would slow the downward movement of soil moisture to such an extent that evaporation and transpiration could easily transfer most of the soil-water back to the atmosphere. Generic requirements for the effectiveness of this design feature are two-fold. First, the soil layer above the repository foot-print must be thick enough to provide sufficient storage of meteoric water (from episodic precipitation events) and accommodate plant roots. Second, the added soil layer must be engineered so as to mitigate thinning by erosional processes and have sufficient thickness to accommodate the roots of common desert plants. Under these two conditions, it is reasonable to expect that modification would be effective for a significant time period and the net infiltration and deep percolation flux would be reduced by orders of magnitude lower

    14. In visual search, guidance by surface type is different than classic guidance

      PubMed Central

      Wolfe, Jeremy M; Reijnen, Ester; Van Wert, Michael J.; Kuzmova, Yoana

      2009-01-01

      Visual search for targets among distractors is more efficient if attention can be guided to targets by attributes like color. In real-world search, we guide attention using information about surfaces. (e.g., paintings are on walls). We compare “classic” color guidance to surface guidance in “scenes” of cubes. When a target can lie on one of many surfaces, color guidance is effective but surface guidance is not (Exp. 1-3). Surface guidance works when cued surfaces are coplanar (Exp. 4) or few in number (Exp. 5). We speculate that surface guidance is slow and limited to very few surfaces at one time. PMID:19236891

    15. Flight Guidance System Requirements Specification

      NASA Technical Reports Server (NTRS)

      Miller, Steven P.; Tribble, Alan C.; Carlson, Timothy M.; Danielson, Eric J.

      2003-01-01

      This report describes a requirements specification written in the RSML-e language for the mode logic of a Flight Guidance System of a typical regional jet aircraft. This model was created as one of the first steps in a five-year project sponsored by the NASA Langley Research Center, Rockwell Collins Inc., and the Critical Systems Research Group of the University of Minnesota to develop new methods and tools to improve the safety of avionics designs. This model will be used to demonstrate the application of a variety of methods and techniques, including safety analysis of system and subsystem requirements, verification of key properties using theorem provers and model checkers, identification of potential sources mode confusion in system designs, partitioning of applications based on the criticality of system hazards, and autogeneration of avionics quality code. While this model is representative of the mode logic of a typical regional jet aircraft, it does not describe an actual or planned product. Several aspects of a full Flight Guidance System, such as recovery from failed sensors, have been omitted, and no claims are made regarding the accuracy or completeness of this specification.

    16. Family planning methods: new guidance.

      PubMed

      1996-10-01

      Presented in this report are the recommendations of two expert groups, the Technical Guidance/Competence Working Group of the US Agency for International Development's Maximizing Access and Quality Initiative and the World Health Organization's Family Planning and Population Unit, regarding currently available family planning methods. The former group addressed key biomedical questions and formulated recommendations about 11 groups of family planning methods: combined oral contraceptives, progestin-only pills during breast feeding, progestin-only injectables, combined injectable contraceptives, Norplant implants, copper-bearing IUDs, tubal occlusion, vasectomy, lactational amenorrhea method, natural family planning, and barrier methods. A table presents the relative importance, by method, of procedures such as pelvic exam, blood pressure reading, breast exam, and screening for sexually transmitted diseases and cervical cancer. The medical eligibility recommendations for each method are also presented in tabular form, with four categories for temporary methods: 1) no restrictions on use, 2) advantages generally outweigh theoretical or proven risks, 3) theoretical or proven risks usually outweigh the advantages, and 4) unacceptable health risks. Included among the 41 conditions for which eligibility criteria are specified are age, smoking, thromboembolic disorder, headaches, irregular vaginal bleeding, family history of breast cancer, obesity, drug interactions, parity, breast feeding, postpartum, and postabortion. The new guidance presented in this report enables providers to give family planning clients expanded contraceptive choices while ensuring method safety and effectiveness. PMID:9342775

    17. Aerocapture Guidance Algorithm Comparison Campaign

      NASA Technical Reports Server (NTRS)

      Rousseau, Stephane; Perot, Etienne; Graves, Claude; Masciarelli, James P.; Queen, Eric

      2002-01-01

      The aerocapture is a promising technique for the future human interplanetary missions. The Mars Sample Return was initially based on an insertion by aerocapture. A CNES orbiter Mars Premier was developed to demonstrate this concept. Mainly due to budget constraints, the aerocapture was cancelled for the French orbiter. A lot of studies were achieved during the three last years to develop and test different guidance algorithms (APC, EC, TPC, NPC). This work was shared between CNES and NASA, with a fruitful joint working group. To finish this study an evaluation campaign has been performed to test the different algorithms. The objective was to assess the robustness, accuracy, capability to limit the load, and the complexity of each algorithm. A simulation campaign has been specified and performed by CNES, with a similar activity on the NASA side to confirm the CNES results. This evaluation has demonstrated that the numerical guidance principal is not competitive compared to the analytical concepts. All the other algorithms are well adapted to guaranty the success of the aerocapture. The TPC appears to be the more robust, the APC the more accurate, and the EC appears to be a good compromise.

    18. Soil Vapor Extraction System Optimization, Transition, and Closure Guidance

      SciTech Connect

      Truex, Michael J.; Becker, Dave; Simon, Michelle A.; Oostrom, Martinus; Rice, Amy K.; Johnson, Christian D.

      2013-02-08

      Soil vapor extraction (SVE) is a prevalent remediation approach for volatile contaminants in the vadose zone. A diminishing rate of contaminant extraction over time is typically observed due to 1) diminishing contaminant mass, and/or 2) slow rates of removal for contamination in low-permeability zones. After a SVE system begins to show indications of diminishing contaminant removal rate, SVE performance needs to be evaluated to determine whether the system should be optimized, terminated, or transitioned to another technology to replace or augment SVE. This guidance specifically addresses the elements of this type of performance assessment. While not specifically presented, the approach and analyses in this guidance could also be applied at the onset of remediation selection for a site as a way to evaluate current or future impacts to groundwater from vadose zone contamination. The guidance presented here builds from existing guidance for SVE design, operation, optimization, and closure from the U.S. Environmental Protection Agency, U.S. Army Corps of Engineers, and the Air Force Center for Engineering and the Environment. The purpose of the material herein is to clarify and focus on the specific actions and decisions related to SVE optimization, transition, and/or closure.

    19. Energy angular momentum closed-loop guidance

      NASA Astrophysics Data System (ADS)

      Patera, Russell P.

      2015-03-01

      A novel guidance algorithm for launch vehicle ascent to the desired mission orbit is proposed. The algorithm uses total specific energy and orbital angular momentum as new state vector parameters. These parameters are ideally suited for the ascent guidance task, since the guidance algorithm steers the launch vehicle along a pre-flight optimal trajectory in energy angular momentum space. The guidance algorithm targets apogee, perigee, inclination and right ascension of ascending node. Computational complexities are avoided by eliminating time in the guidance computation and replacing it with angular momentum magnitude. As a result, vehicle acceleration, mass, thrust, length of motor burns, and staging times are also eliminated from the pitch plane guidance calculations. The algorithm does not involve launch vehicle or target state propagation, which results in minimal computational effort. Proof of concept of the new algorithm is presented using several numerical examples that illustrate performance results.

    20. Guidance assistance, autonomous guidance and assisted distance guidance in precision agriculture

      NASA Astrophysics Data System (ADS)

      Gomez Gil, Jaime

      The present doctoral thesis analyses the potential of technological advances in electronics, telematics and communications for their application in agriculture. Research has been carried out and some prototypes have been developed in four stages: In a first phase, it has been carried out the analysis and development of guidance assistance devices. It has been carried out the development of a microcontroller based device which has been patented by the author of this thesis and later, has been developed and commercialized by the company GMV Sistemas. In a second phase, it has been developed a module of distance guidance which allows the remote driving of an agricultural tractor. There have been made the mechanical modifications in a tractor and the necessary hardware has been installed in order to allow the remote control of the tractor steering. The laptop receives the guidance instructions by means of wireless communication from the computer installed in the base. In a third phase, there have been developed two autonomous guidance systems, one by means of GPS and the other by means of Computer Vision, using as base the platform developed in the previous phase. It is incorporated a module of path generation from the plot outline. With this trajectory, the tractor is able to do most of the farming work in a plot without the participation of the driver. The last phase has been developed at the same time than the previous ones and it is located in Precision Agriculture. In this phase it has been carried out the performance of a centrifugal spreader of fertilizer and it has been developed an application for the generation in a precise way of fertilizer maps. The carried out studies have produced real developments implanted on the machinery of the author's farm. The development of the work has been carried out on a software platform with modules which are intercommunicated between them, because a large part of the developed applications have a common base of work. This

    1. Mission-based guidance system design for autonomous UAVs

      NASA Astrophysics Data System (ADS)

      Moon, Jongki

      The advantages of UAVs in the aviation arena have led to extensive research activities on autonomous technology of UAVs to achieve specific mission objectives. This thesis mainly focuses on the development of a mission-based guidance system. Among various missions expected for future needs, autonomous formation flight (AFF) and obstacle avoidance within safe operation limits are investigated. In the design of an adaptive guidance system for AFF, the leader information except position is assumed to be unknown to a follower. Thus, the only measured information related to the leader is the line-of-sight (LOS) range and angle. Adding an adaptive element with neural networks into the guidance system provides a capability to effectively handle leader's velocity changes. Therefore, this method can be applied to the AFF control systems that use a passive sensing method. In this thesis, an adaptive velocity command guidance system and an adaptive acceleration command guidance system are developed and presented. Since relative degrees of the LOS range and angle are different depending on the outputs from the guidance system, the architecture of the guidance system changes accordingly. Simulations and flight tests are performed using the Georgia Tech UAV helicopter, the GTMax, to evaluate the proposed guidance systems. The simulation results show that the neural network (NN) based adaptive element can improve the tracking performance by effectively compensating for the effect of unknown dynamics. It has also been shown that the combination of an adaptive velocity command guidance system and the existing GTMax autopilot controller performs better than the combination of an adaptive acceleration command guidance system and the GTMax autopilot controller. The successful flight evaluation using an adaptive velocity command guidance system clearly shows that the adaptive guidance control system is a promising solution for autonomous formation flight of UAVs. In addition, an

    2. Entry vehicle performance analysis and atmospheric guidance algorithm for precision landing on Mars. M.S. Thesis - Massachusetts Inst. of Technology

      NASA Technical Reports Server (NTRS)

      Dieriam, Todd A.

      1990-01-01

      Future missions to Mars may require pin-point landing precision, possibly on the order of tens of meters. The ability to reach a target while meeting a dynamic pressure constraint to ensure safe parachute deployment is complicated at Mars by low atmospheric density, high atmospheric uncertainty, and the desire to employ only bank angle control. The vehicle aerodynamic performance requirements and guidance necessary for 0.5 to 1.5 lift drag ratio vehicle to maximize the achievable footprint while meeting the constraints are examined. A parametric study of the various factors related to entry vehicle performance in the Mars environment is undertaken to develop general vehicle aerodynamic design requirements. The combination of low lift drag ratio and low atmospheric density at Mars result in a large phugoid motion involving the dynamic pressure which complicates trajectory control. Vehicle ballistic coefficient is demonstrated to be the predominant characteristic affecting final dynamic pressure. Additionally, a speed brake is shown to be ineffective at reducing the final dynamic pressure. An adaptive precision entry atmospheric guidance scheme is presented. The guidance uses a numeric predictor-corrector algorithm to control downrange, an azimuth controller to govern crossrange, and analytic control law to reduce the final dynamic pressure. Guidance performance is tested against a variety of dispersions, and the results from selected tests are presented. Precision entry using bank angle control only is demonstrated to be feasible at Mars.

    3. Virtual Ultrasound Guidance for Inexperienced Operators

      NASA Technical Reports Server (NTRS)

      Caine, Timothy; Martin, Davis

      2012-01-01

      Medical ultrasound or echocardiographic studies are highly operator-dependent and generally require lengthy training and internship to perfect. To obtain quality echocardiographic images in remote environments, such as on-orbit, remote guidance of studies has been employed. This technique involves minimal training for the user, coupled with remote guidance from an expert. When real-time communication or expert guidance is not available, a more autonomous system of guiding an inexperienced operator through an ultrasound study is needed. One example would be missions beyond low Earth orbit, in which the time delay inherent with communication will make remote guidance impractical.

    4. Experimental and simulation study results of an Adaptive Video Guidance System /AVGS/

      NASA Technical Reports Server (NTRS)

      Schappell, R. T.; Knickerbocker, R. L.

      1975-01-01

      Studies relating to stellar-body exploration programs have pointed out the need for an adaptive guidance scheme capable of providing automatic real-time guidance and site selection capability. For the case of a planetary lander, without such guidance, targeting is limited to what are believed to be generally benign areas in order to ensure a reasonable landing-success probability. Typically, the Mars Viking Lander will be jeopardized by obstacles exceeding 22 centimers in diameter. The benefits of on-board navigation and real-time selection of a landing site and obstacle avoidance have been demonstrated by the Apollo lunar landings, in which man performed the surface sensing and steering functions. Therefore, an Adaptive Video Guidance System (AVGS) has been developed, bread-boarded, and flown on a six-degree-of-freedom simulator.

    5. Faculty of Prehospital Care, Royal College of Surgeons Edinburgh guidance for medical provision for wilderness medicine.

      PubMed

      Mellor, Adrian; Dodds, Naomi; Joshi, Raj; Hall, John; Dhillon, Sundeep; Hollis, Sarah; Davis, Pete; Hillebrandt, David; Howard, Eva; Wilkes, Matthew; Langdana, Burjor; Lee, David; Hinson, Nigel; Williams, Thomas Harcourt; Rowles, Joe; Pynn, Harvey

      2015-01-01

      To support leaders and those involved in providing medical care on expeditions in wilderness environments, the Faculty of Pre-Hospital Care (FPHC) of The Royal College of Surgeons of Edinburgh convened an expert panel of leading healthcare professionals and expedition providers. The aims of this panel were to: (1) provide guidance to ensure the best possible medical care for patients within the geographical, logistical and human factor constraints of an expedition environment. (2) Give aspiring and established expedition medics a 'benchmark' of skills they should meet. (3) Facilitate expedition organisers in selecting the most appropriate medical cover and provider for their planned activity. A system of medical planning is suggested to enable expedition leaders to identify the potential medical risks and their mitigation. It was recognised that the scope of practice for wilderness medicine covers elements of primary healthcare, pre-hospital emergency medicine and preventative medicine. Some unique competencies were also identified. Further to this, the panel recommends the use of a matrix and advisory expedition medic competencies relating to the remoteness and medical threat of the expedition. This advice is aimed at all levels of expedition medic, leader and organiser who may be responsible for delivering or managing the delivery of remote medical care for participants. The expedition medic should be someone equipped with the appropriate medical competencies, scope of practice and capabilities in the expedition environment and need not necessarily be a qualified doctor. In addition to providing guidance regarding the clinical competencies required of the expedition medic, the document provides generic guidance and signposting to the more pertinent aspects of the role of expedition medic. PMID:26629337

    6. 78 FR 38683 - Availability of Guidance: Establishments Guidance for the Selection of a Commercial or Private...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-06-27

      .../Validation_Studies_Pathogen_Detection_Methods.pdf?MOD=AJPERES . Internationally recognized independent... . SUPPLEMENTARY INFORMATION: Background In a Federal Register notice published March 8, 2012 (77 FR 13999), FSIS... regulated establishments to test for pathogens of interest (E. coli O157:H7 and STECs;...

    7. 78 FR 48175 - Retrospective Review of Draft Guidance Documents Issued Before 2010; Withdrawal of Guidances

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-08-07

      ... ``Administrative Practices and Procedures; Good Guidance Practices'' (GGP) (65 FR 56468; September 19, 2000). The... manufacturing practice (cGMP) compliance specific to manufacturing, processing, and dose unit sampling and... following guidances: 1. ``Manufacturing, Processing, or Holding Active Pharmaceutical...

    8. School counselors as gatekeepers: guidance in poor versus affluent neighborhoods.

      PubMed

      Yogev, A; Roditi, H

      1987-01-01

      Previous studies reveal that career guidance is usually based on a mixture of meritocratic criteria (academic ability and achievement) and nonmeritocratic considerations (students' SES and their social labeling by counselors). The present study argues that school counselors in affluent neighborhoods emphasize the meritocratic criteria, while those in poorer neighborhoods tend to focus on the more nonmeritocratic. This hypothesis is examined in a random sample of 210 male, primary school graduates from the 10 state schools of an Israeli town, 125 of whom are from schools in affluent neighborhoods, and 85 from schools in poorer neighborhoods. A path analysis of determinants of guidance to specific high school tracks shows that students' ethnicity and labeling as problematic directly affect guidance by counselors only in the poor neighborhoods. The effect of students' "problems" is due to their being labeled as problematic with respect to psychological or physical attributes rather than to behavioral problems at school. The findings are subsequently interpreted as reflecting a patronizing attitude toward lower status students by counselors. Additional studies which may further elaborate the determinants of guidance in poor versus affluent neighborhoods are proposed. PMID:3434387

    9. The role of registration in accurate surgical guidance.

      PubMed

      Fitzpatrick, J M

      2010-01-01

      Registration is presented as the central issue of surgical guidance. The focus is on the accuracy of approaches employed today, all of which use pre-operative images to guide surgery on rigid anatomy. The three most well-established approaches to guidance, namely the stereotactic frame, point fiducials, and surface matching, are examined in detail, together with two new approaches based on microstereotactic frames. It is shown that each method relies on the registration of points in the image to corresponding points in the operating room, and therefore that the error patterns associated with point registration are similar for all of them. Three types of registration error, namely fiducial localization error (FLE), fiducial registration error (FRE), and target registration error (TRE), are highlighted, as well as two additional guidance errors, namely target localization error and total targeting error, the latter of which is the overall error of the guidance system. Statistical relationships between TRE and FLE, between FRE and FLE, and between TRE, TLE, and TTE are given. Finally some myths concerning fiducial registration are highlighted. PMID:20718266

    10. SPAR-H Step-by-Step Guidance

      SciTech Connect

      April M. Whaley; Dana L. Kelly; Ronald L. Boring; William J. Galyean

      2012-06-01

      Step-by-step guidance was developed recently at Idaho National Laboratory for the US Nuclear Regulatory Commission on the use of the Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method for quantifying Human Failure Events (HFEs). This work was done to address SPAR-H user needs, specifically requests for additional guidance on the proper application of various aspects of the methodology. This paper overviews the steps of the SPAR-H analysis process and highlights some of the most important insights gained during the development of the step-by-step directions. This supplemental guidance for analysts is applicable when plant-specific information is available, and goes beyond the general guidance provided in existing SPAR-H documentation. The steps highlighted in this paper are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff.

    11. Can coffee improve image guidance?

      NASA Astrophysics Data System (ADS)

      Wirz, Raul; Lathrop, Ray A.; Godage, Isuru S.; Burgner-Kahrs, Jessica; Russell, Paul T.; Webster, Robert J.

      2015-03-01

      Anecdotally, surgeons sometimes observe large errors when using image guidance in endonasal surgery. We hypothesize that one contributing factor is the possibility that operating room personnel might accidentally bump the optically tracked rigid body attached to the patient after registration has been performed. In this paper we explore the registration error at the skull base that can be induced by simulated bumping of the rigid body, and find that large errors can occur when simulated bumps are applied to the rigid body. To address this, we propose a new fixation method for the rigid body based on granular jamming (i.e. using particles like ground coffee). Our results show that our granular jamming fixation prototype reduces registration error by 28%-68% (depending on bump direction) in comparison to a standard Brainlab reference headband.

    12. Endangerment assessment guidance. Final report

      SciTech Connect

      Not Available

      1985-10-21

      The directive clarifies the requirement that an endangerment assessment be developed to support all administrative and judicial enforcement actions under Section 106 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and Section 7003 of the Resource Conservation and Recovery Act (RCRA). Before taking enforcement action under these provisions to abate the hazards or potential hazards at a site, the Environmental Protection Agency (EPA) must be able to properly document and justify its assertion that an imminent and substantial endangerment to public health or welfare or the environment may exist. The endangerment assessment provides the documentation and justification. The endangerment assessment is not necessary to support Section 104 actions. It also provides guidance on the content, timing, level of detail, format, and resources required for the preparation of endangerment assessments.

    13. Longwall Guidance and Control Development

      NASA Technical Reports Server (NTRS)

      1982-01-01

      The longwall guidance and control (G&C) system was evaluated to determine which systems and subsystems lent themselves to automatic control in the mining of coal. The upper coal/shale interface was identified as the reference for a vertical G&C system, with two sensors (the natural backgound and the sensitized pick) being used to locate and track this boundary. In order to insure a relatively smooth recession surface (roof and floor of the excavated seam), a last and present cut measuring instrument (acoustic sensor) was used. Potentiometers were used to measure elevations of the shearer arms. The intergration of these components comprised the vertical control system (pitch control). Yaw and roll control were incorporated into a face alignment system which was designed to keep the coal face normal to its external boundaries. Numerous tests, in the laboratory and in the field, have confirmed the feasibility of automatic horizon control, as well as determining the face alignment.

    14. Orion Cislunar Guidance and Navigation

      NASA Technical Reports Server (NTRS)

      D'Souza, Christopher; Crain, Timothy; Clark, Fred C.

      2007-01-01

      The Orion vehicle is being designed to provide nominal crew transport to the lunar transportation stack in low Earth orbit, crew abort prior during transit to the moon, and crew return to Earth once lunar orbit is achieved. Design of guidance and navigation algorithms to perform maneuvers in support of these functions is dependent on the support provided by navigation infrastructure, the performance of the onboard GN&C system, and the choice of trajectory maneuver methodology for outbound and return mission phases. This paper documents the preliminary integrated analyses performed by members of the Orion Orbit GN&C System team investigating the navigation update accuracy of a modern equivalent to the Apollo era ground tracking network and the expected onboard dispersion and navigation errors during a lunar mission using a linear covariance error analysis technique.

    15. Guidance, Navigation, and Control Program

      NASA Technical Reports Server (NTRS)

      Hinkel, Heather; Tamblyn, Scott; Jackson, William L.; Foster, Chris; Brazzel, Jack; Manning, Thomas R.; Clark, Fred; Spehar, Pete; Barrett, Jim D.; Milenkovic, Zoran

      2011-01-01

      The Rendezvous and Proximity Operations Program (RPOP) is real-time guidance, navigation, and control (GN&C) domain piloting-aid software that provides 3D Orbiter graphics and runs on the Space Shuttle's Criticality-3 Payload and General Support Computer (PGSC) in the crew cockpit. This software provides the crew with Situational Awareness during the rendezvous and proximity operations phases of flight. RPOP can be configured from flight to flight, accounting for mission-specific flight scenarios and target vehicles, via initialization load (I-load) data files. The software provides real-time, automated, closed-loop guidance recommendations and the capability to integrate the crew s manual backup techniques. The software can bring all relative navigation sensor data, including the Orbiter's GPC (general purpose computer) data, into one central application to provide comprehensive situational awareness of the rendezvous and proximity operations trajectory. RPOP also can separately maintain trajectory estimates (past, current, and predicted) based on certain data types and co-plot them, in order to show how the various navigation solutions compare. RPOP s best estimate of the relative trajectory is determined by a relative Kalman filter processing data provided by the sensor suite s most accurate sensor, the trajectory control sensor (TCS). Integrated with the Kalman filter is an algorithm that identifies the reflector that the TCS is tracking. Because RPOP runs on PC laptop computers, the development and certification lifecycles are more agile, flexible, and cheaper than those that govern the Orbiter FSW (flight software) that runs in the GPC. New releases of RPOP can be turned around on a 3- to 6-month template, from new Change Request (CR) to certification, depending on the complexity of the changes.

    16. 78 FR 56752 - Interim Staff Guidance Specific Environmental Guidance for Integral Pressurized Water Reactors...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-09-13

      ... COMMISSION Interim Staff Guidance Specific Environmental Guidance for Integral Pressurized Water Reactors... and operate integral pressurized water reactors (iPWR). This guidance applies to environmental reviews... purchase copies of public documents at the NRC's PDR, Room O1-F21, One White Flint North, 11555...

    17. Stochastically optimized monocular vision-based navigation and guidance

      NASA Astrophysics Data System (ADS)

      Watanabe, Yoko

      The objective of this thesis is to design a relative navigation and guidance law for unmanned aerial vehicles, or UAVs, for vision-based control applications. The autonomous operation of UAVs has progressively developed in recent years. In particular, vision-based navigation, guidance and control has been one of the most focused on research topics for the automation of UAVs. This is because in nature, birds and insects use vision as the exclusive sensor for object detection and navigation. Furthermore, it is efficient to use a vision sensor since it is compact, light-weight and low cost. Therefore, this thesis studies the monocular vision-based navigation and guidance of UAVs. Since 2-D vision-based measurements are nonlinear with respect to the 3-D relative states, an extended Kalman filter (EKF) is applied in the navigation system design. The EKF-based navigation system is integrated with a real-time image processing algorithm and is tested in simulations and flight tests. The first closed-loop vision-based formation flight between two UAVs has been achieved, and the results are shown in this thesis to verify the estimation performance of the EKF. In addition, vision-based 3-D terrain recovery was performed in simulations to present a navigation design which has the capability of estimating states of multiple objects. In this problem, the statistical z-test is applied to solve the correspondence problem of relating measurements and estimation states. As a practical example of vision-based control applications for UAVs, a vision-based obstacle avoidance problem is specially addressed in this thesis. A navigation and guidance system is designed for a UAV to achieve a mission of waypoint tracking while avoiding unforeseen stationary obstacles by using vision information. An EKF is applied to estimate each obstacles' position from the vision-based information. A collision criteria is established by using a collision-cone approach and a time-to-go criterion. A minimum

    18. Guidance for performing preliminary assessments under CERCLA

      SciTech Connect

      1991-09-01

      EPA headquarters and a national site assessment workgroup produced this guidance for Regional, State, and contractor staff who manage or perform preliminary assessments (PAs). EPA has focused this guidance on the types of sites and site conditions most commonly encountered. The PA approach described in this guidance is generally applicable to a wide variety of sites. However, because of the variability among sites, the amount of information available, and the level of investigative effort required, it is not possible to provide guidance that is equally applicable to all sites. PA investigators should recognize this and be aware that variation from this guidance may be necessary for some sites, particularly for PAs performed at Federal facilities, PAs conducted under EPA`s Environmental Priorities Initiative (EPI), and PAs at sites that have previously been extensively investigated by EPA or others. The purpose of this guidance is to provide instructions for conducting a PA and reporting results. This guidance discusses the information required to evaluate a site and how to obtain it, how to score a site, and reporting requirements. This document also provides guidelines and instruction on PA evaluation, scoring, and the use of standard PA scoresheets. The overall goal of this guidance is to assist PA investigators in conducting high-quality assessments that result in correct site screening or further action recommendations on a nationally consistent basis.

    19. Vocational Guidance Requests within the International Scene

      ERIC Educational Resources Information Center

      Goodman, Jane; Gillis, Sarah

      2009-01-01

      This article summarizes the work of a diverse group of researchers and practitioners from 5 continents on "Vocational Guidance Requests Within the International Scene" presented in the discussion group at a symposium of the International Association for Educational and Vocational Guidance, the Society for Vocational Psychology, and the National…

    20. Behavioral mechanisms of mammalian sperm guidance

      PubMed Central

      Pérez-Cerezales, Serafín; Boryshpolets, Sergii; Eisenbach, Michael

      2015-01-01

      In mammals, sperm guidance in the oviduct appears essential for successful sperm arrival at the oocyte. Hitherto, three different potential sperm guidance mechanisms have been recognized: thermotaxis, rheotaxis, and chemotaxis, each of them using specific stimuli – a temperature gradient, fluid flow, and a chemoattractant gradient, respectively. Here, we review sperm behavioral in these mechanisms and indicate commonalities and differences between them. PMID:25999361

    1. HANDBOOK: HAZARDOUS WASTE INCINERATION MEASUREMENT GUIDANCE

      EPA Science Inventory

      This publication, Volume III of the Hazardous Waste Incineration Guidance Series, contains general guidance to permit writers in reviewing hazardous waste incineration permit applications and trial burn plans. he handbook is a how-to document dealing with how incineration measure...

    2. 45 CFR 1235.2 - Implementation guidance.

      Code of Federal Regulations, 2010 CFR

      2010-10-01

      ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Implementation guidance. 1235.2 Section 1235.2... SERVICE LOCALLY GENERATED CONTRIBUTIONS IN OLDER AMERICAN VOLUNTEER PROGRAMS § 1235.2 Implementation guidance. ACTION's implementation of section 224 of the DVSA is based on fundamental principles...

    3. 21 CFR 312.145 - Guidance documents.

      Code of Federal Regulations, 2013 CFR

      2013-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Miscellaneous § 312.145 Guidance documents. (a) FDA has... Evaluation and Research (CBER) maintain lists of guidance documents that apply to the centers'...

    4. 21 CFR 312.145 - Guidance documents.

      Code of Federal Regulations, 2012 CFR

      2012-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Miscellaneous § 312.145 Guidance documents. (a) FDA has... Evaluation and Research (CBER) maintain lists of guidance documents that apply to the centers'...

    5. 21 CFR 312.145 - Guidance documents.

      Code of Federal Regulations, 2014 CFR

      2014-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Miscellaneous § 312.145 Guidance documents. (a) FDA has... Evaluation and Research (CBER) maintain lists of guidance documents that apply to the centers'...

    6. 21 CFR 312.145 - Guidance documents.

      Code of Federal Regulations, 2011 CFR

      2011-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Miscellaneous § 312.145 Guidance documents. (a) FDA has... Evaluation and Research (CBER) maintain lists of guidance documents that apply to the centers'...

    7. Educational Guidance for Adults. Identifying Competences.

      ERIC Educational Resources Information Center

      Oakeshott, Martin

      A brief study conducted for the Further Education Unit, Great Britain, defined the competencies associated with educational guidance for adults. The objective was to develop a qualification for educational guidance workers with adults. The project provided an example of applying a competence model to a "higher level" interpersonal field of work.…

    8. Learners' Needs in College-Based Guidance.

      ERIC Educational Resources Information Center

      Further Education Unit, London (England).

      Recent Further Education Unit (FEU) research has provided clear evidence of technical college students' needs for career and educational guidance throughout their program of study. Inhouse technical college guidance services to individuals and institutions offer a number of benefits to both students receiving the services and the institutions…

    9. Guidance Counsellor Strategies for Handling Bullying

      ERIC Educational Resources Information Center

      Power-Elliott, Michleen; Harris, Gregory E.

      2012-01-01

      The purpose of this exploratory-descriptive study was to examine how guidance counsellors in the province of Newfoundland and Labrador would handle a specific verbal-relational bullying incident. Also of interest was guidance counsellor involvement and training in bullying programmes and Positive Behaviour Supports. Data for this study was…

    10. 78 FR 15710 - Strong Sensitizer Guidance

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-03-12

      ...The U.S. Consumer Product Safety Commission (CPSC or Commission) is announcing the availability of a document prepared by CPSC staff titled, ``Strong Sensitizer Guidance.'' This guidance document is intended to clarify the ``strong sensitizer'' definition, assist manufacturers in understanding how CPSC staff would assess whether a substance and/or product containing that substance should be......

    11. Career Guidance in the Elementary School

      ERIC Educational Resources Information Center

      Smith, Phyllis E.; Rost, Paul

      1973-01-01

      Three practical ideas that can be implemented in elementary schools are given: (1) a guidance committee (composed of representatives from each grade level and an administrator) to facilitate involvement in the school guidance program; (2) field trips to introduce students to the world of work and to establish motivations for learning subject…

    12. Social Benefits of Career Guidance. NICEC Briefing.

      ERIC Educational Resources Information Center

      Killeen, John; Watts, Tony; Kidd, Jenny

      Social benefits can be thought of as aggregates of individual benefits, though with possible "snowball" effects. Potential social benefits of career guidance fall into the following two main categories: reducing social exclusion and enhancing social development. Guidance is a way of making the structure of society work, by linking individual needs…

    13. Career Guidance in Wales: Retrospect and Prospect

      ERIC Educational Resources Information Center

      Clark, Mike; Talbot, John

      2006-01-01

      Deregulation of the LEA Careers Service followed by the establishment of the National Assembly for Wales in 1999 led, through consultation, to the establishment of a bi-lingual all-age career guidance service under the banner of Careers Wales. The article traces the history of career guidance in Wales from 1974, showing how it has taken a very…

    14. Career Guidance and Public Mental Health

      ERIC Educational Resources Information Center

      Robertson, Peter J.

      2013-01-01

      Career guidance may have the potential to promote public health by contributing positively to both the prevention of mental health conditions and to population level well-being. The policy implications of this possibility have received little attention. Career guidance agencies are well placed to reach key target groups. Producing persuasive…

    15. Foundations for Policy in Guidance and Counseling.

      ERIC Educational Resources Information Center

      Herr, Edwin L., Ed.; Pinson, Nancy M., Ed.

      This book provides educators, counselors, policy makers, and community members with information about the state of the art of federal and state policy in guidance and counseling. The two chapters in part 1, Overview, are: "Foundations for Policy in Guidance and Counseling: An Introduction", by Edwin L. Herr and Nancy M. Pinson; and "A Counselor…

    16. The Internationalization of Educational and Vocational Guidance

      ERIC Educational Resources Information Center

      Savickas, Mark L.; Van Esbroeck, Raoul; Herr, Edwin L.

      2005-01-01

      The authors identify and discuss the main themes from the discourse on the internationalization of educational and vocational guidance at the 2004 "Symposium on International Perspectives on Career Development," co sponsored by the International Association for Educational and Vocational Guidance and the National Career Development Association.…

    17. 78 FR 57450 - State Rail Plan Guidance

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-09-18

      ... authorized in the Act and available under the High-Speed Intercity Passenger Rail program. This guidance... qualifies States to receive grants for high-speed rail only. Response: Operational information about all... Federal Railroad Administration State Rail Plan Guidance AGENCY: Federal Railroad Administration...

    18. Getting Closer: Workplace Guidance for Lifelong Learning

      ERIC Educational Resources Information Center

      Plant, Peter; Turner, Bob

      2005-01-01

      The purposes of this article are twofold. First, it considers the policy links between guidance and lifelong learning, highlighting in particular the implications of findings from a recent study by the Organisation for Economic Co-operation and Development (OECD). Secondly, it critically compares two approaches to workplace guidance about…

    19. New Tools for Guidance in Business Education.

      ERIC Educational Resources Information Center

      Shimberg, Benjamin

      Several recently developed measurement instruments, the General Aptitude Test Battery (GATB), the Comparative Guidance and Placement Program (CGP), the Kuder Occupational Interest Survey (DD), the Ohio Vocational Interest Survey (OVIS), and the Gordon Occupational Check List, are considered in connection with guidance testing for occupational…

    20. Career Guidance in the Elementary School

      ERIC Educational Resources Information Center

      Leonard, George E.

      1971-01-01

      The purpose of this column is to discuss, describe and disseminate information regarding career guidance principles and practices in the elementary schools. Specifically the activities of the Developmental Career Guidance Projects in inner city Detroit are described. The activities emphasize action involvement of children while didactic learning…

    1. Elementary School Guidance Work Conference. Conference Report.

      ERIC Educational Resources Information Center

      Herr, Edwin L.; Hershberger, James K.

      In October, 1967, 100 invited participants representing all aspects of guidance, education, school administration, counselor education, psychology, and interested government agencies in Pennsylvania met for three days to listen, think, discuss, and hopefully develop some recommendations for those who want a better program of elementary guidance.…

    2. Preparation of Occupational Guidance Counselors. Final Report.

      ERIC Educational Resources Information Center

      North Carolina State Dept. of Public Instruction, Raleigh. Occupational Research Unit.

      The project had three goals: to increase the supply of elementary counselors in North Carolina, to provide guidance services to seventeen elementary schools in a satisfactory manner so the program would be adopted after expiration of the project, and to provide systematic guidance services for children in grades one through six. Four full time…

    3. Encke-Beta Predictor for Orion Bum Targeting and Guidance

      NASA Technical Reports Server (NTRS)

      Robinson, Shane; Scarritt, Sara; Goodman, John L.

      2016-01-01

      The state vector prediction algorithm selected for Orion on-board targeting and guidance is known as the Encke-Beta method. Encke-Beta uses a universal anomaly (beta) as the independent variable, valid for circular, elliptical, parabolic, and hyperbolic orbits. The variable, related to the change in eccentric anomaly, results in integration steps that cover smaller arcs of the trajectory at or near perigee, when velocity is higher. Some burns in the EM-1 and EM-2 mission plans are much longer than burns executed with the Apollo and Space Shuttle vehicles. Burn length, as well as hyperbolic trajectories, has driven the use of the Encke-Beta numerical predictor by the predictor/corrector guidance algorithm in place of legacy analytic thrust and gravity integrals.

    4. Status of automated nap-of-the-earth rotorcraft guidance

      NASA Technical Reports Server (NTRS)

      Coppenbarger, Richard A.; Cheng, Victor H. L.

      1991-01-01

      The status of automated nap-of-the-earth (NOE) flight guidance is discussed by examining two current research efforts that approach the problem of performing obstacle avoidance along a pre-planned course from different perspectives. The first, a real-time guidance system developed by Systems Technology Inc., focuses on the issue of pilot acceptable maneuvers, under the assumption of an ideal, but nonrealizable, obstacle detection system. The second, a system created at NASA Ames, concentrates on the utilization of realistic on-board sensor data for obstacle detection and avoidance-maneuver decisions. This paper examines the strengths and weaknesses of these two approaches, and how they might complement each other. The goal is an automatic NOE system that is both acceptable to pilots and capable of making intelligent use of realistic sensor information and path-selection logic.

    5. Approach guidance for outer planet pioneer missions

      NASA Technical Reports Server (NTRS)

      Bejczy, A. K.

      1975-01-01

      Onboard optical approach guidance measurements for spin-stabilized Pioneer-type spacecraft are discussed. Approach guidance measurement accuracy requirements are outlined. The application concept and operation principle of the V-slit star tracker are discussed within the context of approach guidance measurements and measurables. It is shown that the accuracy of onboard optical approach guidance measurements is inherently coupled to the stability characteristics of the spacecraft spin axis. Geometrical and physical measurement parameters are presented for Pioneer entry probe missions to Uranus via Jupiter or Saturn flyby. The impact of these parameters on both sensor instrumentation and measurement system design is discussed. The need for sensing extended objects is shown. The feasibility of implementing an onboard approach guidance measurement system for Pioneer-type spacecraft is indicated. Two Pioneer 10 onboard measurement experiments performed in May-June 1974 are described.

    6. An adaptive guidance algorithm for aerospace vehicles

      NASA Astrophysics Data System (ADS)

      Bradt, J. E.; Hardtla, J. W.; Cramer, E. J.

      The specifications for proposed space transportation systems are placing more emphasis on developing reusable avionics subsystems which have the capability to respond to vehicle evolution and diverse missions while at the same time reducing the cost of ground support for mission planning, contingency response and verification and validation. An innovative approach to meeting these goals is to specify the guidance problem as a multi-point boundary value problen and solve that problem using modern control theory and nonlinear constrained optimization techniques. This approach has been implemented as Gamma Guidance (Hardtla, 1978) and has been successfully flown in the Inertial Upper Stage. The adaptive guidance algorithm described in this paper is a generalized formulation of Gamma Guidance. The basic equations are presented and then applied to four diverse aerospace vehicles to demonstrate the feasibility of using a reusable, explicit, adaptive guidance algorithm for diverse applications and vehicles.

    7. Entry Guidance for the Reusable Launch Vehicle

      NASA Technical Reports Server (NTRS)

      Lu, Ping

      1999-01-01

      The X-33 Advanced Technology Demonstrator is a half-scale prototype developed to test the key technologies needed for a full-scale single-stage reusable launch vehicle (RLV). The X-33 is a suborbital vehicle that will be launched vertically, and land horizontally. The goals of this research were to develop an alternate entry guidance scheme for the X-33 in parallel to the actual X-33 entry guidance algorithms, provide comparative and complementary study, and identify potential new ways to improve entry guidance performance. Toward these goals, the nominal entry trajectory is defined by a piecewise linear drag-acceleration-versus-energy profile, which is in turn obtained by the solution of a semi-analytical parameter optimization problem. The closed-loop guidance is accomplished by tracking the nominal drag profile with primarily bank-angle modulation on-board. The bank-angle is commanded by a single full-envelope nonlinear trajectory control law. Near the end of the entry flight, the guidance logic is switched to heading control in order to meet strict conditions at the terminal area energy management interface. Two methods, one on ground-track control and the other on heading control, were proposed and examined for this phase of entry guidance where lateral control is emphasized. Trajectory dispersion studies were performed to evaluate the effectiveness of the entry guidance algorithms against a number of uncertainties including those in propulsion system, atmospheric properties, winds, aerodynamics, and propellant loading. Finally, a new trajectory-regulation method is introduced at the end as a promising precision entry guidance method. The guidance principle is very different and preliminary application in X-33 entry guidance simulation showed high precision that is difficult to achieve by existing methods.

    8. Space shuttle guidance, navigation, and control design equations. Volume 3: Guidance

      NASA Technical Reports Server (NTRS)

      1973-01-01

      Space shuttle guidance, navigation, and control design equations are presented. The space-shuttle mission includes three relatively distinct guidance phases which are discussed; atmospheric boost, which is characterized by an adaptive guidance law; extra-atmospheric activities; and re-entry activities, where aerodynamic surfaces are the principal effectors. Guidance tasks include pre-maneuver targeting and powered flight guidance, where powered flight is defined to include the application of aerodynamic forces as well as thruster forces. A flow chart which follows guidance activities throughout the mission from the pre-launch phase through touchdown is presented. The main guidance programs and subroutines used in each phase of a typical rendezvous mission are listed. Detailed software requirements are also presented.

    9. The UNC5C Netrin Receptor Regulates Dorsal Guidance Of Mouse Hindbrain Axons

      PubMed Central

      Kim, Doyeun; Ackerman, Susan L.

      2011-01-01

      The cerebellum receives its input from multiple precerebellar nuclei located in the brainstem, and sends processed information to other brain structures via the cerebellar deep neurons. Guidance molecules that regulate the complex migrations of precerebellar neurons and the initial guidance of their leading processes have been identified. However, the molecules necessary for dorsal guidance of precerebellar axons to the developing cerebellum, or for guidance of decussating axons of the deep nuclei are not known. To determine whether Unc5c plays a role in the dorsal guidance of precerebellar and deep cerebellar axons, we studied axonal trajectories of these neurons in Unc5c-/- mice. Our results show that Unc5c is expressed broadly in the precerebellar and deep cerebellar neurons. Unc5c deletion disrupted long-range dorsal guidance of inferior olivary and pontine axons after crossing the midline. In addition, dorsal guidance of the axons from the medial deep cerebellar and external cuneate neurons was affected in Unc5c-/- mice, as were anterior migrations of pontine neurons. Coincident with the guidance defects of their axons, degeneration of neurons in external cuneate nucleus and subdivisions of inferior olivary nucleus was observed in Unc5c-/- mice. Lastly, transgenic expression of Unc5c in deep neurons and pontine neurons by the Atoh1 promoter rescued defects of the medial deep cerebellar and pontine axons observed in Unc5c-/- embryos, demonstrating that Unc5c acts cell autonomously in the guidance of these axons. Our results suggest that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain. PMID:21307253

    10. Remediation of metal-contaminated soils with the addition of materials--part I: characterization and viability studies for the selection of non-hazardous waste materials and silicates.

      PubMed

      González-Núñez, R; Alba, M D; Orta, M M; Vidal, M; Rigol, A

      2011-11-01

      Contamination episodes in soils require interventions to attenuate their impact. These actions are often based on the addition of materials to increase contaminant retention in the soil and to dilute the contaminant concentration. Here, non-hazardous wastes (such as sugar foam, fly ash and a material produced by the zeolitization of fly ash) and silicates (including bentonites) were tested and fully characterized in the laboratory to select suitable materials for remediating metal-contaminated soils. Data from X-ray fluorescence (XRF), N(2) adsorption/desorption isotherms, X-ray diffraction (XRD) and scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM-EDX) analyses revealed the chemical composition, specific surface area and the phases appearing in the materials. A pH titration test allowed the calculation of their acid neutralization capacity (ANC). The metal sorption and desorption capacities of the waste materials and silicates were also estimated. Sugar foam, fly ash and the zeolitic material were the best candidate materials. Sugar foam was selected because of its high ANC (17000 meq kg(-1)), and the others were selected because of their larger distribution coefficients and lower sorption reversibilities than those predicted in the contaminated soils. PMID:22018740

    11. MGR COMPLIANCE PROGRAM GUIDANCE PACKAGE FOR RADIATION PROTECTION EQUIPMENT, INSTRUMENTATION AND FACILITIES

      SciTech Connect

      N /A

      2000-02-01

      This Compliance Program Guidance Package identifies the regulatory guidance and industry codes and standards addressing radiation protection equipment, instrumentation, and support facilities considered to be appropriate for radiation protection at the Monitored Geologic Repository (MGR). Included are considerations relevant to radiation monitoring instruments, calibration, contamination control and decontamination, respiratory protection equipment, and general radiation protection facilities. The scope of this Guidance Package does not include design guidance relevant to criticality monitoring, area radiation monitoring, effluent monitoring, and airborne radioactivity monitoring systems since they are considered to be the topics of specific design and construction requirements (i.e., ''fixed'' or ''built-in'' systems). This Guidance Package does not address radiation protection design issues; it addresses the selection and calibration of radiation monitoring instrumentation to the extent that the guidance is relevant to the operational radiation protection program. Radon and radon progeny monitoring instrumentation is not included in the Guidance Package since such naturally occurring radioactive materials do not fall within the NRC's jurisdiction at the MGR.

    12. Additional EIPC Study Analysis. Final Report

      SciTech Connect

      Hadley, Stanton W; Gotham, Douglas J.; Luciani, Ralph L.

      2014-12-01

      Between 2010 and 2012 the Eastern Interconnection Planning Collaborative (EIPC) conducted a major long-term resource and transmission study of the Eastern Interconnection (EI). With guidance from a Stakeholder Steering Committee (SSC) that included representatives from the Eastern Interconnection States Planning Council (EISPC) among others, the project was conducted in two phases. Phase 1 involved a long-term capacity expansion analysis that involved creation of eight major futures plus 72 sensitivities. Three scenarios were selected for more extensive transmission- focused evaluation in Phase 2. Five power flow analyses, nine production cost model runs (including six sensitivities), and three capital cost estimations were developed during this second phase. The results from Phase 1 and 2 provided a wealth of data that could be examined further to address energy-related questions. A list of 14 topics was developed for further analysis. This paper brings together the earlier interim reports of the first 13 topics plus one additional topic into a single final report.

    13. Numerical Skip-Entry Guidance

      NASA Technical Reports Server (NTRS)

      Tigges, Michael; Crull, Timothy; Rea, Jeremy; Johnson, Wyatt

      2006-01-01

      This paper assesses a preliminary guidance and targeting strategy for accomplishing Skip-Entry (SE) flight during a lunar return-capsule entry flight. One of the primary benefits of flying a SE trajectory is to provide the crew with continuous Continental United States (CONUS) landing site access throughout the lunar month. Without a SE capability, the capsule must land either in water or at one of several distributed land sites in the Southern Hemisphere for a significant portion of a lunar month using a landing and recovery scenario similar to that employed during the Apollo program. With a SE trajectory, the capsule can land either in water at a site in proximity to CONUS or at one of several distributed landing sites within CONUS, thereby simplifying the operational requirements for crew retrieval and vehicle recovery, and possibly enabling a high degree of vehicle reusability. Note that a SE capability does not require that the vehicle land on land. A SE capability enables a longer-range flight than a direct-entry flight, which permits the vehicle to land at a much greater distance from the Entry Interface (EI) point. This does not exclude using this approach to push the landing point to a water location in proximity of CONUS and utilizing water or airborne recovery forces.

    14. Optofluidic control of axonal guidance

      NASA Astrophysics Data System (ADS)

      Gu, Ling; Ordonez, Simon; Black, Bryan; Mohanty, Samarendra K.

      2013-03-01

      Significant efforts are being made for control on axonal guidance due to its importance in nerve regeneration and in the formation of functional neuronal circuitry in-vitro. These include several physical (topographic modification, optical force, and electric field), chemical (surface functionalization cues) and hybrid (electro-chemical, photochemical etc) methods. Here, we report comparison of the effect of linear flow versus microfluidic flow produced by an opticallydriven micromotor in guiding retinal ganglion axons. A circularly polarized laser tweezers was used to hold, position and spin birefringent calcite particle near growth cone, which in turn resulted in microfluidic flow. The flow rate and resulting shear-force on axons could be controlled by a varying the power of the laser tweezers beam. The calcite particles were placed separately in one chamber and single particle was transported through microfluidic channel to another chamber containing the retina explant. In presence of flow, the turning of axons was found to strongly correlate with the direction of flow. Turning angle as high as 90° was achieved. Optofluidic-manipulation can be applied to other types of mammalian neurons and also can be extended to stimulate mechano-sensing neurons.

    15. [Recipients adverse reactions: guidance supports].

      PubMed

      Bazin, A

      2010-12-01

      Since 1994, adverse effects of transfusion transmitted to the French haemovigilance network are registered on "e-fit", the database of the French agency for the safety of health products (Afssaps). In order to improve their analysis, guidance supports have been made by Afssaps working groups. Each support deals with a blood transfusion side effect and is composed of five parts including pathophysiological mechanisms, diagnostic criteria, management recommendations, etiologic investigations and rules of filing the notification form on e-fit. The major characteristics of sheets published or soon-to-be published are presented: transfusion-related acute lung injury, transfusion-transmitted bacterial infection, non-haemolytic febrile reaction, allergic reaction, transfusion-associated circulatory overload, hypotensive transfusion reaction, alloimmunization, erythrocyte incompatibility reaction and hemosiderosis. These new supports give relevant guidelines allowing a better analysis and evaluation of recipients' adverse reactions, particularly their diagnosis, gravity and accountability. They could also initiate studies in European and international haemovigilance and transfusion networks. PMID:21051267

    16. Technical bases and guidance for the use of composite soil sampling for demonstrating compliance with radiological release criteria

      SciTech Connect

      Vitkus, Timothy J.

      2012-04-24

      This guidance provides information on methodologies and the technical bases that licensees should consider for incorporating composite sampling strategies into final status survey (FSS) plans. In addition, this guidance also includes appropriate uses of composite sampling for generating the data for other decommissioning site investigations such as characterization or other preliminary site investigations.

    17. 78 FR 54949 - Major Project Financial Plan Guidance

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-09-06

      ... TRANSPORTATION Federal Highway Administration Major Project Financial Plan Guidance AGENCY: Federal Highway... Major Project Financial Plan Guidance outlining the procedures the FHWA will follow when reviewing and approving Financial Plans. The proposed Major Project Financial Plan Guidance incorporates changes...

    18. Percutaneous needle placement using laser guidance: a practical solution

      NASA Astrophysics Data System (ADS)

      Xu, Sheng; Kapoor, Ankur; Abi-Jaoudeh, Nadine; Imbesi, Kimberly; Hong, Cheng William; Mazilu, Dumitru; Sharma, Karun; Venkatesan, Aradhana M.; Levy, Elliot; Wood, Bradford J.

      2013-03-01

      In interventional radiology, various navigation technologies have emerged aiming to improve the accuracy of device deployment and potentially the clinical outcomes of minimally invasive procedures. While these technologies' performance has been explored extensively, their impact on daily clinical practice remains undetermined due to the additional cost and complexity, modification of standard devices (e.g. electromagnetic tracking), and different levels of experience among physicians. Taking these factors into consideration, a robotic laser guidance system for percutaneous needle placement is developed. The laser guidance system projects a laser guide line onto the skin entry point of the patient, helping the physician to align the needle with the planned path of the preoperative CT scan. To minimize changes to the standard workflow, the robot is integrated with the CT scanner via optical tracking. As a result, no registration between the robot and CT is needed. The robot can compensate for the motion of the equipment and keep the laser guide line aligned with the biopsy path in real-time. Phantom experiments showed that the guidance system can benefit physicians at different skill levels, while clinical studies showed improved accuracy over conventional freehand needle insertion. The technology is safe, easy to use, and does not involve additional disposable costs. It is our expectation that this technology can be accepted by interventional radiologists for CT guided needle placement procedures.

    19. Optimal guidance law in quantum mechanics

      SciTech Connect

      Yang, Ciann-Dong Cheng, Lieh-Lieh

      2013-11-15

      Following de Broglie’s idea of a pilot wave, this paper treats quantum mechanics as a problem of stochastic optimal guidance law design. The guidance scenario considered in the quantum world is that an electron is the flight vehicle to be guided and its accompanying pilot wave is the guidance law to be designed so as to guide the electron to a random target driven by the Wiener process, while minimizing a cost-to-go function. After solving the stochastic optimal guidance problem by differential dynamic programming, we point out that the optimal pilot wave guiding the particle’s motion is just the wavefunction Ψ(t,x), a solution to the Schrödinger equation; meanwhile, the closed-loop guidance system forms a complex state–space dynamics for Ψ(t,x), from which quantum operators emerge naturally. Quantum trajectories under the action of the optimal guidance law are solved and their statistical distribution is shown to coincide with the prediction of the probability density function Ψ{sup ∗}Ψ. -- Highlights: •Treating quantum mechanics as a pursuit-evasion game. •Reveal an interesting analogy between guided flight motion and guided quantum motion. •Solve optimal quantum guidance problem by dynamic programming. •Gives a formal proof of de Broglie–Bohm’s idea of a pilot wave. •The optimal pilot wave is shown to be a wavefunction solved from Schrödinger equation.

    20. Three-dimensional multimodal image-guidance for neurosurgery

      SciTech Connect

      Peters, T.; Munger, P.; Comeau, R.; Evans, A.; Olivier, A.; Davey, B.

      1996-04-01

      The authors address the use of multimodality imaging as an aid to the planning and guidance of neurosurgical procedures, and discuss the integration of anatomical (CT and MRI), vascular (DSA), and functional (PET) data for presentation to the surgeon during surgery. The workstation is an enhancement of a commercially available system, and in addition to the guidance offered via a hand-held probe, it incorporates the use of multimodality imaging and adds enhanced realism to the surgeon through the use of a stereoscopic three-dimensional (3-D) image display. The probe may be visualized stereoscopically in single or multimodality images. The integration of multimodality data in this manner provides the surgeon with a complete overview of brain structures on which he is performing surgery, or through which he is passing probes or cannulas, enabling him to avoid critical vessels and/or structures of functional significance.

    1. Fuzzy logic sliding mode control for command guidance law design.

      PubMed

      Elhalwagy, Y Z; Tarbouchi, M

      2004-04-01

      Recently, the combination of sliding mode and fuzzy logic techniques has emerged as a promising methodology for dealing with nonlinear, uncertain, dynamical systems. In this paper, a sliding mode control algorithm combined with a fuzzy control scheme is developed for the trajectory control of a command guidance system. The acceleration command input is mathematically derived. The proposed controller is used to compensate for the influence of unmodeled dynamics and to alleviate chattering. Simulation results show that the proposed controller gives good system performance in the face of system parameters variation and external disturbances. In addition, they show the effectiveness of the proposed missile guidance law against different engagement scenarios where the results demonstrate better performance over the conventional sliding mode control. PMID:15098583

    2. A Markov Chain Approach to Probabilistic Swarm Guidance

      NASA Technical Reports Server (NTRS)

      Acikmese, Behcet; Bayard, David S.

      2012-01-01

      This paper introduces a probabilistic guidance approach for the coordination of swarms of autonomous agents. The main idea is to drive the swarm to a prescribed density distribution in a prescribed region of the configuration space. In its simplest form, the probabilistic approach is completely decentralized and does not require communication or collabo- ration between agents. Agents make statistically independent probabilistic decisions based solely on their own state, that ultimately guides the swarm to the desired density distribution in the configuration space. In addition to being completely decentralized, the probabilistic guidance approach has a novel autonomous self-repair property: Once the desired swarm density distribution is attained, the agents automatically repair any damage to the distribution without collaborating and without any knowledge about the damage.

    3. Next Generation Advanced Video Guidance Sensor Development and Test

      NASA Technical Reports Server (NTRS)

      Howard, Richard T.; Bryan, Thomas C.; Lee, Jimmy; Robertson, Bryan

      2009-01-01

      The Advanced Video Guidance Sensor (AVGS) was the primary docking sensor for the Orbital Express mission. The sensor performed extremely well during the mission, and the technology has been proven on orbit in other flights too. Parts obsolescence issues prevented the construction of more AVGS units, so the next generation of sensor was designed with current parts and updated to support future programs. The Next Generation Advanced Video Guidance Sensor (NGAVGS) has been tested as a breadboard, two different brassboard units, and a prototype. The testing revealed further improvements that could be made and demonstrated capability beyond that ever demonstrated by the sensor on orbit. This paper presents some of the sensor history, parts obsolescence issues, radiation concerns, and software improvements to the NGAVGS. In addition, some of the testing and test results are presented. The NGAVGS has shown that it will meet the general requirements for any space proximity operations or docking need.

    4. Guidance manual for conducting technology demonstration activities

      SciTech Connect

      Jolley, Robert L.; Morris, Michael I.; Singh, Suman P.N.

      1991-12-01

      This demonstration guidance manual has been prepared to assist Martin Marietta Energy Systems, Inc. (Energy Systems), staff in conducting demonstrations. It is prepared in checklist style to facilitate its use and assumes that Energy Systems personnel have project management responsibility. In addition to a detailed step-by-step listing of procedural considerations, a general checklist, logic flow diagram, and several examples of necessary plans are included to assist the user in developing an understanding of the many complex activities required to manage technology demonstrations. Demonstrations are pilot-scale applications of often innovative technologies to determine the commercial viability of the technologies to perform their designed function. Demonstrations are generally conducted on well-defined problems for which existing technologies or processes are less than satisfactory in terms of effectiveness, cost, and/or regulatory compliance. Critically important issues in demonstration management include, but are not limited to, such factors as communications with line and matrix management and with the US Department of Energy (DOE) and Energy Systems staff responsible for management oversight, budgetary and schedule requirements, regulatory compliance, and safety.

    5. Ultrasound image guidance of cardiac interventions

      NASA Astrophysics Data System (ADS)

      Peters, Terry M.; Pace, Danielle F.; Lang, Pencilla; Guiraudon, Gérard M.; Jones, Douglas L.; Linte, Cristian A.

      2011-03-01

      Surgical procedures often have the unfortunate side-effect of causing the patient significant trauma while accessing the target site. Indeed, in some cases the trauma inflicted on the patient during access to the target greatly exceeds that caused by performing the therapy. Heart disease has traditionally been treated surgically using open chest techniques with the patient being placed "on pump" - i.e. their circulation being maintained by a cardio-pulmonary bypass or "heart-lung" machine. Recently, techniques have been developed for performing minimally invasive interventions on the heart, obviating the formerly invasive procedures. These new approaches rely on pre-operative images, combined with real-time images acquired during the procedure. Our approach is to register intra-operative images to the patient, and use a navigation system that combines intra-operative ultrasound with virtual models of instrumentation that has been introduced into the chamber through the heart wall. This paper illustrates the problems associated with traditional ultrasound guidance, and reviews the state of the art in real-time 3D cardiac ultrasound technology. In addition, it discusses the implementation of an image-guided intervention platform that integrates real-time ultrasound with a virtual reality environment, bringing together the pre-operative anatomy derived from MRI or CT, representations of tracked instrumentation inside the heart chamber, and the intra-operatively acquired ultrasound images.

    6. Improved image guidance of coronary stent deployment

      NASA Astrophysics Data System (ADS)

      Close, Robert A.; Abbey, Craig K.; Whiting, James S.

      2000-04-01

      Accurate placement and expansion of coronary stents is hindered by the fact that most stents are only slightly radiopaque, and hence difficult to see in a typical coronary x-rays. We propose a new technique for improved image guidance of multiple coronary stents deployment using layer decomposition of cine x-ray images of stented coronary arteries. Layer decomposition models the cone-beam x-ray projections through the chest as a set of superposed layers moving with translation, rotation, and scaling. Radiopaque markers affixed to the guidewire or delivery balloon provide a trackable feature so that the correct vessel motion can be measured for layer decomposition. In addition to the time- averaged layer image, we also derive a background-subtracted image sequence which removes moving background structures. Layer decomposition of contrast-free vessels can be used to guide placement of multiple stents and to assess uniformity of stent expansion. Layer decomposition of contrast-filled vessels can be used to measure residual stenosis to determine the adequacy of stent expansion. We demonstrate that layer decomposition of a clinical cine x-ray image sequence greatly improves the visibility of a previously deployed stent. We show that layer decomposition of contrast-filled vessels removes background structures and reduces noise.

    7. Aeroassist flight experiment guidance Quiet Time

      NASA Technical Reports Server (NTRS)

      Striepe, Scott A.; Suit, William T.

      1988-01-01

      The science experiments for the Aeroassist Flight Experiment (AFE) will be greatly enhanced by taking measurements with no Reaction Control System (RCS) contamination just before perigee. Methods of modifying the AFE guidance to accomplish this are discussed. Several methods that could give up to 30 seconds of quiet time were investigated and the results of these guidance modifications shown. A 20 second quiet time is definitely possible and a 30 second quiet time may be possible if the guidance can be inactive past perigee. Some of the most significant being the criterion for determining if the mission is threatened. A limited follow-on test program is outlined.

    8. Navigating through 'a labyrinth' of guidance.

      PubMed

      Pearson, Susan

      2014-09-01

      Devising a strategy to deliver safe water to thousands of outlets spread across numerous buildings is always going to be a challenge, so how do you navigate your way through a bewildering labyrinth of sometimes contradictory guidance documents? Is there, in fact, simply too much guidance? Posing this question at a recent one-day conference on waterborne infections in healthcare facilities, Paul Nolan, authorised water engineer (AE), and operations manager for PFI provider, Lend Lease, took delegates through a review of the latest guidance and regulations, as Susan Pearson reports. PMID:25282983

    9. 76 FR 43332 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2011-07-20

      ...; Class II Special Controls Guidance Document: Focused Ultrasound Stimulator System for Aesthetic Use... Guidance Document: Focused Ultrasound Stimulator System for Aesthetic Use.'' This guidance document describes a means by which focused ultrasound stimulator systems for aesthetic use may comply with...

    10. Low Gravity Guidance System for Airborne Microgravity Research

      NASA Technical Reports Server (NTRS)

      Rieke, W. J.; Emery, E. F.; Boyer, E. O.; Hegedus, C.; ODonoghue, D. P.

      1996-01-01

      Microgravity research techniques have been established to achieve a greater understanding of the role of gravity in the fundamentals of a variety of physical phenomena and material processing. One technique in use at the NASA Lewis Research Center involves flying Keplarian trajectories with a modified Lear Jet and DC-9 aircraft to achieve a highly accurate Microgravity environment by neutralizing accelerations in all three axis of the aircraft. The Low Gravity Guidance System (LGGS) assists the pilot and copilot in flying the trajectories by displaying the aircraft acceleration data in a graphical display format. The Low Gravity Guidance System is a microprocessor based system that acquires and displays the aircraft acceleration information. This information is presented using an electroluminescent display mounted over the pilot's instrument panel. The pilot can select the Microgravity range that is required for a given research event. This paper describes the characteristics, design, calibration and testing of the Low Gravity Guidance System Phase 3, significant lessons from earlier systems and the developmental work on future systems.

    11. Small Body GN&C Research Report: A G-Guidance Enhancement to Increase Mission Functionality

      NASA Technical Reports Server (NTRS)

      Carson, John M., III; Ackmese, Behcet

      2006-01-01

      G-Guidance is a robust G&C (guidance and control) algorithm developed under the small-body GN&C task. The G-Guidance scheme utilizes a model predictive control approach, along with a convexification of the governing dynamics, control constraints, and trajectory/state constraints. This report details an enhancement to the FY2005 G-Guidance algorithm; the addition of a fire-second approach helps to nullify velocity errors and hit desired final velocities much more precisely than the original Fire-first scheme developed in FY2005. The enhancement preserves the primary benefit of the algorithm, which is to ensure required thruster silent times during trajectory maneuvers. The fire-second scheme increases the versatility of the algorithm for missions employing G-Guidance. For instance, a landing sequence could employ the fire-second scheme to ensure a null final velocity at landing, whereas an ascent sequence could utilize a fire-first scheme to ensure there is no drift of the spacecraft toward the ground at the beginning of the maneuver. Examples are provided within to demonstrate a fire-first versus fire-second guidance scheme. As in the existing G-Guidance algorithm, the examples and schemes incorporate gravity models and thruster firing times into discrete dynamics that are solved as a optimal control problem to minimize fuel consumption or thruster energy expenditure.

    12. Mo-Fe catalysts supported on activated carbon for synthesis of liquid fuels by the Fischer-Tropsch process: effect of Mo addition on reducibility, activity, and hydrocarbon selectivity

      SciTech Connect

      Wenping Ma; Edwin L. Kugler; James Wright; Dady B. Dadyburjor

      2006-12-15

      The effects of Mo loading (0-12 wt %) on the properties of activated-carbon- (AC-) supported Fe-Cu-K catalysts and their performance for Fischer-Tropsch synthesis are studied. Physicochemical properties studied include particle size, reducibility, and dispersion, and catalytic properties include activity, selectivity, and stability. Catalysts were characterized by N{sub 2} adsorption, energy-dispersive spectroscopy, X-ray diffraction (XRD), H{sub 2} temperature-programmed reduction (TPR), and CO chemisorption. Catalyst performance was studied at 310-320{sup o}C, 2.2 MPa, 3 Nl/g-cat/h, and H{sub 2}/CO = 0.9. Reaction results in a fixed-bed reactor show that addition of 6% Mo into the Fe-Cu-K/AC catalyst improves catalyst stability without sacrificing activity, but activity is suppressed dramatically on a 12% Mo-loaded catalyst. Detectable hydrocarbons of C{sub 1} to C{sub 34} are produced on the Fe-Cu-K/AC catalysts with or without Mo. However, the addition of Mo results in the production of more CH{sub 4} and less C{sub 5+} hydrocarbons. The Mo promoter greatly enhances secondary reactions of olefins, leading to a large amount of internal olefins (i.e., other than 1-olefins) in the product. TPR shows that a strong interaction between Fe and Mo oxides is present, and the extent of reduction of Fe is suppressed after addition of Mo to the Fe-Cu-K catalyst. CO-chemisorption and XRD studies show increased iron dispersion and decreased particle size of the iron carbide and iron oxide after the addition of Mo. Segregation of iron active sites, thereby preventing them from agglomerating, and a larger number of active sites on the 6% Mo catalyst are possible reasons for the improved stability and higher activity of Mo-promoted catalysts. 54 refs., 5 figs., 6 tabs.

    13. 7 CFR 1794.7 - Guidance.

      Code of Federal Regulations, 2011 CFR

      2011-01-01

      ...)); RUS Bulletin 1794A-601 provides guidance in preparing the ER for proposed actions which require EAs... (§ 1794.22(b)) and EAs (§ 1794.23(b)). A copy of this bulletin is available upon request by contacting...

    14. 7 CFR 1794.7 - Guidance.

      Code of Federal Regulations, 2013 CFR

      2013-01-01

      ...)); RUS Bulletin 1794A-601 provides guidance in preparing the ER for proposed actions which require EAs... (§ 1794.22(b)) and EAs (§ 1794.23(b)). A copy of this bulletin is available upon request by contacting...

    15. 7 CFR 1794.7 - Guidance.

      Code of Federal Regulations, 2014 CFR

      2014-01-01

      ...)); RUS Bulletin 1794A-601 provides guidance in preparing the ER for proposed actions which require EAs... (§ 1794.22(b)) and EAs (§ 1794.23(b)). A copy of this bulletin is available upon request by contacting...

    16. 7 CFR 1794.7 - Guidance.

      Code of Federal Regulations, 2012 CFR

      2012-01-01

      ...)); RUS Bulletin 1794A-601 provides guidance in preparing the ER for proposed actions which require EAs... (§ 1794.22(b)) and EAs (§ 1794.23(b)). A copy of this bulletin is available upon request by contacting...

    17. Delta launch vehicle inertial guidance system (DIGS)

      NASA Technical Reports Server (NTRS)

      Duck, K. I.

      1973-01-01

      The Delta inertial guidance system, part of the Delta launch vehicle improvement effort, has been flown on three launches and was found to perform as expected for a variety of mission profiles and vehicle configurations.

    18. 21 CFR 316.50 - Guidance documents.

      Code of Federal Regulations, 2010 CFR

      2010-04-01

      ... USE ORPHAN DRUGS Availability of Information § 316.50 Guidance documents. FDA's Office of Orphan... Federal Register. A request for a copy of the list should be directed to the Office of Orphan...

    19. 7 CFR 1794.7 - Guidance.

      Code of Federal Regulations, 2010 CFR

      2010-01-01

      ... Analysis, Stop 1522, 1400 Independence Avenue, SW., Washington, DC 20250-1522. (b) Water and waste program... appropriate State Director. State Directors may provide supplemental guidance to meet state and local laws...

    20. Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level Resistance and Increased Replicative Capacity

      PubMed Central

      Anstett, Kaitlin; Fusco, Robert; Cutillas, Vincent; Mesplède, Thibault

      2015-01-01

      ABSTRACT We have previously shown that the addition of the raltegravir/elvitegavir (RAL/EVG) primary resistance mutation N155H to the R263K dolutegravir (DTG) resistance mutation partially compensated for the fitness cost imposed by R263K while also slightly increasing DTG resistance in vitro (K. Anstett, T. Mesplede, M. Oliveira, V. Cutillas, and M. A. Wainberg, J Virol 89:4681–4684, 2015, doi:10.1128/JVI.03485-14). Since many patients failing RAL/EVG are given DTG as part of rescue therapy, and given that the N155H substitution often is found in combination with other compensatory resistance mutations in such individuals, we investigated the effects of multiple such substitutions within integrase (IN) on each of integrase function, HIV-1 infectivity, and levels of drug resistance. To this end, each of the L74M, E92Q, T97A, E157Q, and G163R substitutions were introduced into NL4.3 subtype B HIV-1 vectors harboring N155H and R263K in tandem [termed NL4.3IN(N155H/R263K)]. Relevant recombinant integrase enzymes also were expressed, and purified and biochemical assays of strand transfer efficiency as well as viral infectivity and drug resistance studies were performed. We found that the addition of T97A, E157Q, or G163R somewhat improved the affinity of INN155H/R263K for its target DNA substrate, while the presence of L74M or E92Q had a negative effect on this process. However, viral infectivity was significantly decreased from that of NL4.3IN(N155H/R263K) after the addition of each tertiary mutation, and no increases in levels of DTG resistance were observed. This work shows that the compensatory mutations that evolve after N155H under continued DTG or RAL/EVG pressure in patients are unable to improve either enzyme efficiency or viral infectivity in an N155H/R263K background. IMPORTANCE In contrast to other drugs, dolutegravir has not selected for resistance in HIV-positive individuals when used in first-line therapy. We had previously shown that HIV containing

    1. 77 FR 14403 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2012-03-09

      ...: Norovirus Serological Reagents.'' This guidance document describes a means by which norovirus serological... by following the recommendations in the guidance document or by some other means that...

    2. Soil screening guidance: User`s guide

      SciTech Connect

      1996-04-01

      The Soil Screening Guidance is a tool that the U.S. Environmental Protection Agency (EPA) developed to help standardize and accelerate the evaluation and cleanup of contaminated soils at sites on the National Priorities List (NPL) with future residential land use. This guidance provides a methodology for environmental science/engineering professionals to calculate risk-based, site-specific, soil screening levels (SSLs) for contaminants in soil that may be used to identify areas needing further investigation at NPL sites.

    3. Vehicle health management for guidance, navigation and control systems

      NASA Technical Reports Server (NTRS)

      Radke, Kathleen; Frazzini, Ron; Bursch, Paul; Wald, Jerry; Brown, Don

      1993-01-01

      The objective of the program was to architect a vehicle health management (VHM) system for space systems avionics that assures system readiness for launch vehicles and for space-based dormant vehicles. The platforms which were studied and considered for application of VHM for guidance, navigation and control (GN&C) included the Advanced Manned Launch System (AMLS), the Horizontal Landing-20/Personnel Launch System (HL-20/PLS), the Assured Crew Return Vehicle (ACRV) and the Extended Duration Orbiter (EDO). This set was selected because dormancy and/or availability requirements are driving the designs of these future systems.

    4. Guidance for training program evaluation

      SciTech Connect

      Not Available

      1984-01-01

      An increased concern about the training of nuclear reactor operators resulted from the incident at TMI-2 in 1979. Purpose of this guide is to provide a general framework for the systematic evaluation of training programs for DOE Category-A reactors. The primary goal of such evaluations is to promote continuing quality improvements in the selection, training and qualification programs.

    5. Tunable filters for JWST Fine Guidance Sensor

      NASA Astrophysics Data System (ADS)

      Rowlands, Neil; Evans, Clinton; Greenberg, Elliot; Gregory, Phil; Scott, Alan; Thibault, Simon; Poirier, Michel; Doyon, Rene; Hutchings, John B.; Alexander, Russ

      2004-10-01

      The Canadian contribution to the James Webb Space Telescope (JWST) mission will be the Fine Guidance Sensor (FGS), incorporating a science-observing mode using tunable filters. We describe here the requirements, the opto-mechanical design concept and bread-board test results for the JWST FGS tunable filters. The FGS requires two continuously tunable filters over the wavelength ranges 1.2 - 2.4 microns and 2.4 - 4.8 microns each having a spectral resolution in the range of R~70 to 200. The selected implementation uses dielectric coated Fabry-Perot etalon plates with a small air gaps. The design finesse is ~30 and the filters are used in 3rd order. The operating temperature is ~35K. Current coating designs provide implementations that require only five blocking filters in each wavelength range to suppress unwanted orders. The filters will be scanned via the use of low voltage piezo-electric transducers. We present results from cryogenic tests of coating samples, PZT actuators and a structural model. The PZT actuators were found have a displacement of ~3.3 microns at 30K with an applied voltage of 125V, more than sufficient for the required scan of the Fabry-Perot plate spacing. The prototype etalon coating was found to be very stable cryogenically, having a measured change of transmission of only ~1% at 77K. The same coating on a 12.7 mm thick substrate, similar to that planned for the filter, was found to have a 18 nm peak-to-valley surface figure change when cooled to 30K. These results demonstrate that the development of tunable filters for the JWST FGS is on track to meet the technology readiness requirements of the program.

    6. Influence of the addition of transition metals (Cr, Zr, Mo) on the properties of MnOx-FeOx catalysts for low-temperature selective catalytic reduction of NOx by Ammonia.

      PubMed

      Zhou, Changcheng; Zhang, Yaping; Wang, Xiaolei; Xu, Haitao; Sun, Keqin; Shen, Kai

      2013-02-15

      The co-precipitation and citric acid methods were employed to prepare MnO(x)-FeO(x) catalysts for the low-temperature selective catalytic reduction (SCR) of NO(x) by ammonia. It was found that the Mn-Fe (CP) sample obtained from the co-precipitation method, which exhibited low crystalline of manganese oxides on the surface, high specific surface area and abundant acid sites at the surface, had better catalytic activity. The effects of doping different transition metals (Mo, Zr, Cr) in the Mn-Fe (CP) catalysts were further investigated. The study suggested that the addition of Cr can obviously reduce the take-off temperature of Mn-Fe catalyst to 90°C, while the impregnation of Zr and Mo raised that remarkably. The texture and micro-structure analysis revealed that for the Cr-doped Mn-Fe catalysts, the active components had better dispersion with less agglomeration and sintering and the largest BET surface specific area. In situ FTIR study indicated that the addition of Cr can increase significantly the surface acidity, especially, the Lewis acid sites, and promote the formation of the intermediate -NH(3)(+). H(2)-TPR results confirmed the better low-temperature redox properties of Mn-Fe-Cr. PMID:23142012

    7. Percutaneous Closure of Patent Ductus Arteriosus Under Echocardiographic Guidance.

      PubMed

      Khan, Muhammad Arif; ElSegaier, Milad; Galal, Mohammed Omar

      2016-06-01

      Percutaneous closure of patent ductus arteriosus (PDA) is done in the cardiac catheterization laboratory, usually under fluoroscopic and angiographic guidance. The aortogram is used for assessing PDAsize and shape the pre-device implantation. Additionally, post-device aortograms are applied for the assessment of device position, profile and residual shunt. Angiograms expose patient to radiation and possible untoward effects of contrast media. Recently, transthoracic echocardiography has been utilized to guide in PDAclosure to avoid radiation exposure as well as contrast material. On two occasions, we were obligated by special circumstances to close the PDAunder echocardiography guidance. First case was a 6-month baby girl with mild signs of heart failure having moderate size PDA. She underwent device closure under transthoracic echocardiogram as the angiographic system had stopped working during the procedure. Second case was a 6-year girl, weighting 16-kg with chronic renal failure. She had moderate size PDAclosed by device under transthoracic echocardiographic, guidance avoiding the use of contrast agent due to chronic renal failure. PMID:27353996

    8. The Role of Registration in Accurate Surgical Guidance

      PubMed Central

      Fitzpatrick, J. Michael

      2016-01-01

      Registration is presented as the central issue of surgical guidance. The focus is on the accuracy of approaches employed today, all of which use pre-operative images to guide surgery on rigid anatomy. The three most well established approaches to guidance—the stereotactic frame, point fiducials, and surface matching—are examined in detail, along with two new approaches based on microstereotactic frames. It is shown that each method relies on the registration of points in the image to corresponding points in the operating room, and therefore that the error patterns associated with point registration are similar for all of them. Three types of registration error—fiducial localization error (FLE), fiducial registration error (FRE), and target registration error (TRE) are highlighted, as well as two additional guidance errors—target localization error, and total targeting error, the latter of which is the overall error of the guidance system. Statistical relationships between TRE and FLE, between FRE and FLE, and among TRE, TLE and TTE are given. Finally some myths concerning fiducial registration are highlighted. PMID:20718266

    9. A semi-analytical guidance algorithm for autonomous landing

      NASA Astrophysics Data System (ADS)

      Lunghi, Paolo; Lavagna, Michèle; Armellin, Roberto

      2015-06-01

      One of the main challenges posed by the next space systems generation is the high level of autonomy they will require. Hazard Detection and Avoidance is a key technology in this context. An adaptive guidance algorithm for landing that updates the trajectory to the surface by means of an optimal control problem solving is here presented. A semi-analytical approach is proposed. The trajectory is expressed in a polynomial form of minimum order to satisfy a set of boundary constraints derived from initial and final states and attitude requirements. By imposing boundary conditions, a fully determined guidance profile is obtained, function of a restricted set of parameters. The guidance computation is reduced to the determination of these parameters in order to satisfy path constraints and other additional constraints not implicitly satisfied by the polynomial formulation. The algorithm is applied to two different scenarios, a lunar landing and an asteroidal landing, to highlight its general validity. An extensive Monte Carlo test campaign is conducted to verify the versatility of the algorithm in realistic cases, by the introduction of attitude control systems, thrust modulation, and navigation errors. The proposed approach proved to be flexible and accurate, granting a precision of a few meters at touchdown.

    10. Missile guidance law design using adaptive cerebellar model articulation controller.

      PubMed

      Lin, Chih-Min; Peng, Ya-Fu

      2005-05-01

      An adaptive cerebellar model articulation controller (CMAC) is proposed for command to line-of-sight (CLOS) missile guidance law design. In this design, the three-dimensional (3-D) CLOS guidance problem is formulated as a tracking problem of a time-varying nonlinear system. The adaptive CMAC control system is comprised of a CMAC and a compensation controller. The CMAC control is used to imitate a feedback linearization control law and the compensation controller is utilized to compensate the difference between the feedback linearization control law and the CMAC control. The online adaptive law is derived based on the Lyapunov stability theorem to learn the weights of receptive-field basis functions in CMAC control. In addition, in order to relax the requirement of approximation error bound, an estimation law is derived to estimate the error bound. Then the adaptive CMAC control system is designed to achieve satisfactory tracking performance. Simulation results for different engagement scenarios illustrate the validity of the proposed adaptive CMAC-based guidance law. PMID:15940993

    11. Atmospheric Ascent Guidance for Rocket-Powered Launch Vehicles

      NASA Technical Reports Server (NTRS)

      Dukeman, Greg A.

      2002-01-01

      An advanced ascent guidance algorithm for rocket- powered launch vehicles is developed. This algorithm cyclically solves the calculus-of-variations two-point boundary-value problem starting at vertical rise completion through main engine cutoff. This is different from traditional ascent guidance algorithms which operate in a simple open-loop mode until high dynamic pressure (including the critical max-Q) portion of the trajectory is over, at which time guidance operates under the assumption of negligible aerodynamic acceleration (i.e., vacuum dynamics). The initial costate guess is corrected based on errors in the terminal state constraints and the transversality conditions. Judicious approximations are made to reduce the order and complexity of the state/costate system. Results comparing guided launch vehicle trajectories with POST open-loop trajectories are given verifying the basic formulation of the algorithm. Multiple shooting is shown to be a very effective numerical technique for this application. In particular, just one intermediate shooting point, in addition to the initial shooting point, is sufficient to significantly reduce sensitivity to the guessed initial costates. Simulation results from a high-fidelity trajectory simulation are given for the case of launch to sub-orbital cutoff conditions as well as launch to orbit conditions. An abort to downrange landing site formulation of the algorithm is presented.

    12. 78 FR 55727 - Draft Guidance for Industry on Recommendations for Preparation and Submission of Animal Food...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-09-11

      ... if an animal food ingredient is already the subject of an approved FAP. Who to contact for more... Preparation and Submission of Animal Food Additive Petitions; Availability AGENCY: Food and Drug... Submission of Animal Food Additive Petitions.'' This draft guidance describes the types of information...

    13. Planning guidance for the Chemical Stockpile Emergency Preparedness Program

      SciTech Connect

      Shumpert, B.L.; Watson, A.P.; Sorensen, J.H.

      1995-02-01

      This planning guide was developed under the direction of the U.S. Army and the Federal Emergency Management Agency (FEMA) which jointly coordinate and direct the development of the Chemical Stockpile Emergency Preparedness Program (CSEPP). It was produced to assist state, local, and Army installation planners in formulating and coordinating plans for chemical events that may occur at the chemical agent stockpile storage locations in the continental United States. This document provides broad planning guidance for use by both on-post and off-post agencies and organizations in the development of a coordinated plan for responding to chemical events. It contains checklists to assist in assuring that all important aspects are included in the plans and procedures developed at each Chemical Stockpile Disposal Program (CSDP) location. The checklists are supplemented by planning guidelines in the appendices which provide more detailed guidance regarding some issues. The planning guidance contained in this document will help ensure that adequate coordination between on-post and off-post planners occurs during the planning process. This planning guide broadly describes an adequate emergency planning base that assures that critical planning decisions will be made consistently at every chemical agent stockpile location. This planning guide includes material drawn from other documents developed by the FEMA, the Army, and other federal agencies with emergency preparedness program responsibilities. Some of this material has been developed specifically to meet the unique requirements of the CSEPP. In addition to this guidance, other location-specific documents, technical studies, and support studies should be used as needed to assist in the planning at each of the chemical agent stockpile locations to address the specific hazards and conditions at each location.

    14. Cone beam CT guidance provides superior accuracy for complex needle paths compared with CT guidance

      PubMed Central

      Braak, S J; Fütterer, J J; van Strijen, M J L; Hoogeveen, Y L; de Lange, F; Schultze Kool, L J

      2013-01-01

      Objective: To determine the accuracy of cone beam CT (CBCT) guidance and CT guidance in reaching small targets in relation to needle path complexity in a phantom. Methods: CBCT guidance combines three-dimensional CBCT imaging with fluoroscopy overlay and needle planning software to provide real-time needle guidance. The accuracy of needle positioning, quantified as deviation from a target, was assessed for inplane, angulated and double angulated needle paths. Four interventional radiologists reached four targets along the three paths using CBCT and CT guidance. Accuracies were compared between CBCT and CT for each needle path and between the three approaches within both modalities. The effect of user experience in CBCT guidance was also assessed. Results: Accuracies for CBCT were significantly better than CT for the double angulated needle path (2.2 vs 6.7 mm, p<0.001) for all radiologists. CBCT guidance showed no significant differences between the three approaches. For CT, deviations increased with increasing needle path complexity from 3.3 mm for the inplane placements to 4.4 mm (p=0.007) and 6.7 mm (p<0.001) for the angulated and double angulated CT-guided needle placements, respectively. For double angulated needle paths, experienced CBCT users showed consistently higher accuracies than trained users [1.8 mm (range 1.2–2.2) vs 3.3 mm (range 2.1–7.2) deviation from target, respectively; p=0.003]. Conclusion: In terms of accuracy, CBCT is the preferred modality, irrespective of the level of user experience, for more difficult guidance procedures requiring double angulated needle paths as in oncological interventions. Advances in knowledge: Accuracy of CBCT guidance has not been discussed before. CBCT guidance allows accurate needle placement irrespective of needle path complexity. For angulated and double-angulated needle paths, CBCT is more accurate than CT guidance. PMID:23913308

    15. 76 FR 61098 - Guidance for 1-Hour SO2

      Federal Register 2010, 2011, 2012, 2013, 2014

      2011-10-03

      ...Notice is hereby given that the EPA has posted its draft non- binding guidance titled, ``Guidance for 1-Hour SO2 NAAQS SIP Submissions'' on its Web site. The EPA invites public comments on this guidance document during the comment period specified below, and plans to issue an updated version of the guidance after reviewing timely submitted...

    16. Constituent Aspects of Workplace Guidance in Secondary VET

      ERIC Educational Resources Information Center

      Swager, Robert; Klarus, Ruud; van Merriënboer, Jeroen J. G.; Nieuwenhuis, Loek F. M.

      2015-01-01

      Purpose: This paper aims to present an integrated model of workplace guidance to enhance awareness of what constitutes good guidance, to improve workplace guidance practices in vocational education and training. Design/methodology/approach: To identify constituent aspects of workplace guidance, a systematic search of Web of Science was conducted,…

    17. Earlier Guidance Opportunities: Priorities for the 1970's.

      ERIC Educational Resources Information Center

      Nemec, William E., Ed.

      "Earlier Guidance Opportunities (EGO): Priorities for the 1970's" was the topic for this Ohio Elementary Guidance Conference. In his keynote address entitled "New Perspectives on the Guidance of Younger Children - Can We Afford to Delay Vocational Guidance?" Dr. George E. Hill used EGO to say, "Education Gives Opportunity,""Ego's Grow on…

    18. Trajectory-Shaping Guidance with final speed and load factor constraints.

      PubMed

      Yu, Wenbin; Chen, Wanchun

      2015-05-01

      This paper describes the design of a guidance law used for guiding a hypersonic gliding vehicle against a ground target from a near-vertical orientation with a specified final speed and a near-zero final load factor. The guidance law consists of two terms: one is Trajectory-Shaping Guidance (TSG) used for steering the vehicle to the target from the specified orientation; the other is Final-Speed-Control Scheme (FSCS) used for controlling the vehicle to perform lateral maneuver to adjust the final speed. Further, the generalized closed form solutions of TSG are obtained from a more general linearized engagement model, where the speed of the vehicle can be an arbitrary positive function of time. By analyzing these solutions, the stability domain of the guidance coefficients is obtained such that the final load factor is zero. This domain is not affected by the change rate of the speed. Thus, according to this analysis, the proposed guidance law can achieve a near zero final load factor by properly selecting the guidance coefficients in the stability domain. PMID:25532937

    19. Launch flexibility using NLP guidance and remote wind sensing

      NASA Technical Reports Server (NTRS)

      Cramer, Evin J.; Bradt, Jerre E.; Hardtla, John W.

      1990-01-01

      This paper examines the use of lidar wind measurements in the implementation of a guidance strategy for a nonlinear programming (NLP) launch guidance algorithm. The NLP algorithm uses B-spline command function representation for flexibility in the design of the guidance steering commands. Using this algorithm, the guidance system solves a two-point boundary value problem at each guidance update. The specification of different boundary value problems at each guidance update provides flexibility that can be used in the design of the guidance strategy. The algorithm can use lidar wind measurements for on pad guidance retargeting and for load limiting guidance steering commands. Examples presented in the paper use simulated wind updates to correct wind induced final orbit errors and to adjust the guidance steering commands to limit the product of the dynamic pressure and angle-of-attack for launch vehicle load alleviation.

    20. Siloxane containing addition polyimides

      NASA Technical Reports Server (NTRS)

      Maudgal, S.; St. Clair, T. L.

      1984-01-01

      Addition polyimide oligomers have been synthesized from bis(gamma-aminopropyl) tetramethyldisiloxane and 3, 3', 4, 4'-benzophenonetetracarboxylic dianhydride using a variety of latent crosslinking groups as endcappers. The prepolymers were isolated and characterized for solubility (in amide, chlorinated and ether solvents), melt flow and cure properties. The most promising systems, maleimide and acetylene terminated prepolymers, were selected for detailed study. Graphite cloth reinforced composites were prepared and properties compared with those of graphite/Kerimid 601, a commercially available bismaleimide. Mixtures of the maleimide terminated system with Kerimid 601, in varying proportions, were also studied.

    1. Guidance and control of swarms of spacecraft

      NASA Astrophysics Data System (ADS)

      Morgan, Daniel James

      There has been considerable interest in formation flying spacecraft due to their potential to perform certain tasks at a cheaper cost than monolithic spacecraft. Formation flying enables the use of smaller, cheaper spacecraft that distribute the risk of the mission. Recently, the ideas of formation flying have been extended to spacecraft swarms made up of hundreds to thousands of 100-gram-class spacecraft known as femtosatellites. The large number of spacecraft and limited capabilities of each individual spacecraft present a significant challenge in guidance, navigation, and control. This dissertation deals with the guidance and control algorithms required to enable the flight of spacecraft swarms. The algorithms developed in this dissertation are focused on achieving two main goals: swarm keeping and swarm reconfiguration. The objectives of swarm keeping are to maintain bounded relative distances between spacecraft, prevent collisions between spacecraft, and minimize the propellant used by each spacecraft. Swarm reconfiguration requires the transfer of the swarm to a specific shape. Like with swarm keeping, minimizing the propellant used and preventing collisions are the main objectives. Additionally, the algorithms required for swarm keeping and swarm reconfiguration should be decentralized with respect to communication and computation so that they can be implemented on femtosats, which have limited hardware capabilities. The algorithms developed in this dissertation are concerned with swarms located in low Earth orbit. In these orbits, Earth oblateness and atmospheric drag have a significant effect on the relative motion of the swarm. The complicated dynamic environment of low Earth orbits further complicates the swarm-keeping and swarm-reconfiguration problems. To better develop and test these algorithms, a nonlinear, relative dynamic model with J2 and drag perturbations is developed. This model is used throughout this dissertation to validate the algorithms

    2. 78 FR 37231 - Guidance for Industry; Guidance on Abbreviated New Drug Applications: Stability Testing of Drug...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-06-20

      ...The Food and Drug Administration (FDA or Agency) is announcing the availability of a guidance entitled ``ANDAs: Stability Testing of Drug Substances and Products.'' FDA is recommending generic drug manufacturers follow the stability testing recommendations in the International Conference on Harmonisation (ICH) guidances Q1A (R2) through Q1E. The use of these ICH recommendations will......

    3. Raising the Profile of Career Guidance: Educational and Vocational Guidance Practitioner

      ERIC Educational Resources Information Center

      Hiebert, Bryan

      2009-01-01

      In 2007 the International Association for Educational and Vocational Guidance (IAEVG) launched the Educational and Vocational Guidance Practitioner credential (EVGP) as one means of formally acknowledging the knowledge, skills, and personal attributes that practitioners need in order to provide quality career development services to clients. This…

    4. FACILITATING LEARNING AND INDIVIDUAL DEVELOPMENT, TOWARD A THEORY FOR ELEMENTARY GUIDANCE. MINNESOTA GUIDANCE SERIES.

      ERIC Educational Resources Information Center

      GRAMS, ARMIN

      A THEORY UPON WHICH ELEMENTARY GUIDANCE PROGRAMS CAN BE SOUNDLY DESIGNED IS PRESENTED. A MAJOR THEME IS THAT PSYCHOLOGICAL WELL-BEING OR GOOD ADJUSTMENT IS RELATED TO LEARNED, INDIVIDUAL COMPETENCIES SUCH AS COMMUNICATION AND INTERACTION IN DEPTH WITH OTHERS. THE APPROPRIATE CONCERN OF GUIDANCE THEN BECOMES TO FOSTER THESE COMPETENCIES, THUS…

    5. Radiation Protection Guidance for Diagnostic and Interventional X-Ray Procedures; Federal Guidance Report No. 14

      EPA Science Inventory

      Federal Guidance Report No. 14 provides federal facilities that use diagnostic and interventional x-ray equipment with updated recommendations for keeping doses as low as reasonably achievable without compromising the quality of patient care, This guidance is an update of Federal...

    6. A Comparison of Two Skip Entry Guidance Algorithms

      NASA Technical Reports Server (NTRS)

      Rea, Jeremy R.; Putnam, Zachary R.

      2007-01-01

      system saturation. The comparison of the performance criteria has led to a down select and guidance merger that will take the best ideas from each algorithm to create one skip entry guidance algorithm for the Orion vehicle.

    7. Boron addition to alloys

      SciTech Connect

      Coad, B. C.

      1985-08-20

      A process for addition of boron to an alloy which involves forming a melt of the alloy and a reactive metal, selected from the group consisting of aluminum, titanium, zirconium and mixtures thereof to the melt, maintaining the resulting reactive mixture in the molten state and reacting the boric oxide with the reactive metal to convert at least a portion of the boric oxide to boron which dissolves in the resulting melt, and to convert at least portion of the reactive metal to the reactive metal oxide, which oxide remains with the resulting melt, and pouring the resulting melt into a gas stream to form a first atomized powder which is subsequently remelted with further addition of boric oxide, re-atomized, and thus reprocessed to convert essentially all the reactive metal to metal oxide to produce a powdered alloy containing specified amounts of boron.

    8. Guidance and control, 1993; Annual Rocky Mountain Guidance and Control Conference, 16th, Keystone, CO, Feb. 6-10, 1993

      NASA Technical Reports Server (NTRS)

      Culp, Robert D. (Editor); Bickley, George (Editor)

      1993-01-01

      Papers from the sixteenth annual American Astronautical Society Rocky Mountain Guidance and Control Conference are presented. The topics covered include the following: advances in guidance, navigation, and control; control system videos; guidance, navigation and control embedded flight control systems; recent experiences; guidance and control storyboard displays; and applications of modern control, featuring the Hubble Space Telescope (HST) performance enhancement study.

    9. Measuring Integrated Socioemotional Guidance at School: Factor Structure and Reliability of the Socioemotional Guidance Questionnaire (SEG-Q)

      ERIC Educational Resources Information Center

      Jacobs, Karen; Struyf, Elke

      2013-01-01

      Socioemotional guidance of students has recently become an integral part of education, however no instrument exists to measure integrated socioemotional guidance. This study therefore examines the factor structure and reliability of the Socioemotional Guidance Questionnaire. Psychometric properties of the Socioemotional Guidance Questionnaire and…

    10. Constrained reconstructions for 4D intervention guidance

      NASA Astrophysics Data System (ADS)

      Kuntz, J.; Flach, B.; Kueres, R.; Semmler, W.; Kachelrieß, M.; Bartling, S.

      2013-05-01

      Image-guided interventions are an increasingly important part of clinical minimally invasive procedures. However, up to now they cannot be performed under 4D (3D + time) guidance due to the exceedingly high x-ray dose. In this work we investigate the applicability of compressed sensing reconstructions for highly undersampled CT datasets combined with the incorporation of prior images in order to yield low dose 4D intervention guidance. We present a new reconstruction scheme prior image dynamic interventional CT (PrIDICT) that accounts for specific image features in intervention guidance and compare it to PICCS and ASD-POCS. The optimal parameters for the dose per projection and the numbers of projections per reconstruction are determined in phantom simulations and measurements. In vivo experiments in six pigs are performed in a cone-beam CT; measured doses are compared to current gold-standard intervention guidance represented by a clinical fluoroscopy system. Phantom studies show maximum image quality for identical overall doses in the range of 14 to 21 projections per reconstruction. In vivo studies reveal that interventional materials can be followed in 4D visualization and that PrIDICT, compared to PICCS and ASD-POCS, shows superior reconstruction results and fewer artifacts in the periphery with dose in the order of biplane fluoroscopy. These results suggest that 4D intervention guidance can be realized with today’s flat detector and gantry systems using the herein presented reconstruction scheme.

    11. ICDF Complex Waste Profile and Verification Sample Guidance

      SciTech Connect

      W. M. Heileson

      2006-10-01

      This guidance document will assist waste generators who characterize waste streams destined for disposal at the Idaho Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Disposal Facility (ICDF) Complex. The purpose of this document is to develop a conservative but appropriate way to (1) characterize waste for entry into the ICDF; (2) ensure compliance with the waste acceptance criteria; and (3) facilitate disposal at the ICDF landfill or evaporation pond. In addition, this document will establish the waste verification process used by ICDF personnel to ensure that untreated waste meets applicable ICDF acceptance limits

    12. Microstructure and Mechanical Properties of Long Ti-6Al-4V Rods Additively Manufactured by Selective Electron Beam Melting Out of a Deep Powder Bed and the Effect of Subsequent Hot Isostatic Pressing

      NASA Astrophysics Data System (ADS)

      Lu, S. L.; Tang, H. P.; Ning, Y. P.; Liu, N.; StJohn, D. H.; Qian, M.

      2015-09-01

      An array of eight long Ti-6Al-4V rods (diameter: 12 mm; height: 300 mm) have been additively manufactured, vertically and perpendicular to the powder bed, by selective electron beam melting (SEBM). The purpose was to identify and understand the challenges of fabricating Ti-6Al-4V samples or parts from a deep powder bed (more than 200-mm deep) by SEBM and the necessity of applying post heat treatment. The resulting microstructure and mechanical properties of these Ti-6Al-4V rods were characterized along their building ( i.e., axial) direction by dividing each rod into three segments (top, middle, and bottom), both before ( i.e., as-built) and after hot isostatic pressing (HIP). The as-built microstructure of each rod was inhomogeneous; it was coarsest in the top segment, which showed a near equilibrium α- β lamellar structure, and finest in the bottom segment, which featured a non-equilibrium mixed structure. The tensile properties varied along the rod axis, especially the ductility, but all tensile properties met the requirements specified by ASTM F3001-14. HIP increased the relative density from 99.03 pct of the theoretical density (TD) to 99.90 pct TD and homogenized the microstructure thereby leading to highly consistent tensile properties along the rod axis. The temperature of the stainless steel substrate used in the powder bed was monitored. The as-built inhomogeneous microstructure is attributed to the temperature gradient in the deep powder bed. Post heat treatment is thus necessary for Ti-6Al-4V samples or parts manufactured from a deep powder bed by SEBM. This differs from the additive manufacturing of small samples or parts from a shallow powder bed (less than 100-mm deep) by SEBM.

    13. Student Guidance and Attention to Diversity in the Processes of Quality Assurance in Higher Education

      ERIC Educational Resources Information Center

      Ferreira, Camino; Vidal, Javier; Vieira, María José

      2014-01-01

      The main objective of this article is to analyse the importance given to student guidance and diversity in the standards and criteria used in the quality accreditation and evaluation processes in Europe and the US. Agencies selected in this study are the members of ENQA (European Association for Quality Assurance in Higher Education), EQAR…

    14. Identification and Implementation of a Career Guidance and Counseling Model for Small Districts. Final Report.

      ERIC Educational Resources Information Center

      Lang, Sheri K.

      This final report describes a project that identified the core components of a model program for the delivery of career guidance and counseling to all students at grades 7-12 and then developed and implemented the program. Project activities included selection and use of an advisory committee, provision of inservice training, program development,…

    15. RADON REDUCTION TECHNIQUES FOR EXISTING DETACHED HOUSES - TECHNICAL GUIDANCE (THIRD EDITION) FOR ACTIVE SOIL DEPRESSURIZATION SYSTEMS

      EPA Science Inventory

      This technical guidance document is designed to aid in the selection, design, installation and operation of indoor radon reduction techniques using soil depressurization in existing houses. Its emphasis is on active soil depressurization; i.e., on systems that use a fan to depre...

    16. Distance Guidance for Lifelong Learners in Hong Kong: Development of an Online Programme Preference Assessment Instrument

      ERIC Educational Resources Information Center

      Zhang, Weiyuan; Ng, Tak-Kay

      2006-01-01

      In order to build a knowledge-based society and meet the needs of lifelong education, open learning opportunities are growing at exponential rates. While such growth is commendable, there appears to be a very strong demand for distance guidance services in open education programme selection. The purpose of this study was to develop the online…

    17. HUMAN FACTORS GUIDANCE FOR CONTROL ROOM EVALUATION

      SciTech Connect

      OHARA,J.; BROWN,W.; STUBLER,W.; HIGGINS,J.; WACHTEL,J.; PERSENSKY,J.J.

      2000-07-30

      The Human-System Interface Design Review Guideline (NUREG-0700, Revision 1) was developed by the US Nuclear Regulatory Commission (NRC) to provide human factors guidance as a basis for the review of advanced human-system interface technologies. The guidance consists of three components: design review procedures, human factors engineering guidelines, and a software application to provide design review support called the ``Design Review Guideline.'' Since it was published in June 1996, Rev. 1 to NUREG-0700 has been used successfully by NRC staff, contractors and nuclear industry organizations, as well as by interested organizations outside the nuclear industry. The NRC has committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool in the face of emerging and rapidly changing technology. This paper addresses the current research to update of NUREG-0700 based on the substantial work that has taken place since the publication of Revision 1.

    18. VTOL shipboard letdown guidance system analysis

      NASA Technical Reports Server (NTRS)

      Phatak, A. V.; Karmali, M. S.

      1983-01-01

      Alternative letdown guidance strategies are examined for landing of a VTOL aircraft onboard a small aviation ship under adverse environmental conditions. Off line computer simulation of shipboard landing task is utilized for assessing the relative merits of the proposed guidance schemes. The touchdown performance of a nominal constant rate of descent (CROD) letdown strategy serves as a benchmark for ranking the performance of the alternative letdown schemes. Analysis of ship motion time histories indicates the existence of an alternating sequence of quiescent and rough motions called lulls and swells. A real time algorithms lull/swell classification based upon ship motion pattern features is developed. The classification algorithm is used to command a go/no go signal to indicate the initiation and termination of an acceptable landing window. Simulation results show that such a go/no go pattern based letdown guidance strategy improves touchdown performance.

    19. Human Genetic Disorders of Axon Guidance

      PubMed Central

      Engle, Elizabeth C.

      2010-01-01

      This article reviews symptoms and signs of aberrant axon connectivity in humans, and summarizes major human genetic disorders that result, or have been proposed to result, from defective axon guidance. These include corpus callosum agenesis, L1 syndrome, Joubert syndrome and related disorders, horizontal gaze palsy with progressive scoliosis, Kallmann syndrome, albinism, congenital fibrosis of the extraocular muscles type 1, Duane retraction syndrome, and pontine tegmental cap dysplasia. Genes mutated in these disorders can encode axon growth cone ligands and receptors, downstream signaling molecules, and axon transport motors, as well as proteins without currently recognized roles in axon guidance. Advances in neuroimaging and genetic techniques have the potential to rapidly expand this field, and it is feasible that axon guidance disorders will soon be recognized as a new and significant category of human neurodevelopmental disorders. PMID:20300212

    20. Vehicle Battery Safety Roadmap Guidance

      SciTech Connect

      Doughty, D. H.

      2012-10-01

      The safety of electrified vehicles with high capacity energy storage devices creates challenges that must be met to assure commercial acceptance of EVs and HEVs. High performance vehicular traction energy storage systems must be intrinsically tolerant of abusive conditions: overcharge, short circuit, crush, fire exposure, overdischarge, and mechanical shock and vibration. Fail-safe responses to these conditions must be designed into the system, at the materials and the system level, through selection of materials and safety devices that will further reduce the probability of single cell failure and preclude propagation of failure to adjacent cells. One of the most important objectives of DOE's Office of Vehicle Technologies is to support the development of lithium ion batteries that are safe and abuse tolerant in electric drive vehicles. This Roadmap analyzes battery safety and failure modes of state-of-the-art cells and batteries and makes recommendations on future investments that would further DOE's mission.

    1. Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance

      PubMed Central

      2006-01-01

      and validly measure the specific concepts at issue. The glossary defines many of the terms used in this guidance. In particular, the term instrument refers to the actual questions or items contained in a questionnaire or interview schedule along with all the additional information and documentation that supports the use of these items in producing a PRO measure (e.g., interviewer training and instructions, scoring and interpretation manual). The term conceptual framework refers to how items are grouped according to subconcepts or domains (e.g., the item walking without help may be grouped with another item, walking with difficulty, within the domain of ambulation, and ambulation may be further grouped into the concept of physical ability). FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidance documents describe the Agency's current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word should in Agency guidance documents means that something is suggested or recommended but not required. First publication of the Draft Guidance by the Food and Drug Administration- February 2006. PMID:17034633

    2. [Guidance for education on medicines in school].

      PubMed

      Kito, Hideaki

      2013-01-01

      To promote the education on medicines in school, guidance is, as a rule, to be given in the health education of the Subject, "Health and Physical Education" indicated as a curriculum standard in lower and upper secondary school, and in the health guidance, which carry out in Special Activities and Integrated Studies, etc. Guidance is mainly carried by the teacher for health and physical in health education and school nurse teacher (yogo teacher) in health guidance. In health education we have only limited school hours, and generally use the text book. Some teachers feel resistance to teach medicines because of needs on the special knowledge, however teachers should deal with medicines based on curriculum standard. School pharmacist is a member of school, and has a special knowledge for medicines, and he/she can support teachers as a provider of teaching materials, an adviser, and for a guest teacher. It is important for school pharmacist to understand the contents indicated in curriculum standard and to use glossary to be able to understand for children. In the guidance of health, it is not necessary to teach based on curriculum standard, and it can deal with advanced contents on medicines. However it is important to understand for children what are appropriate contents according to the development stage. To use the packages and instructions for medicines provided at home are good materials for children to have interest the medicines in their guidance. The objectives of education on medicines enable children to cultivate practical abilities for the maintenance and improvement of health. PMID:24292178

    3. Functional MR imaging as a new paradigm for image guidance.

      PubMed

      Assumpcao, Lia; Choti, Michael; Pawlik, Timothy M; Gecshwind, Jean-Francois; Kamel, Ihab R

      2009-11-01

      Guidance and monitoring of locoregional minimally invasive treatment for primary or secondary liver tumor are critical to ensuring success and efficacy of therapy. In this article, we review advanced MR imaging techniques, including MR spectroscopy, diffusion and perfusion MR imaging, which can provide essential in vivo physiologic and metabolic information. These innovative imaging techniques can provide potential additional criteria to assess tumor response in addition to the accepted yet often limited Response Evaluation Criteria in Solid Tumors (RECIST) and the European Association for the Study of the Liver (EASL) criteria, which are based on decrease of tumor size and lesion enhancement, respectively. In this article, we also discuss the role of tumor size and enhancement in addition to apparent diffusion coefficient (ADC) findings after radiofrequency ablation (RFA), transarterial chemoembolization (TACE), and radioembolization. PMID:19048335

    4. Chance-Constrained Guidance With Non-Convex Constraints

      NASA Technical Reports Server (NTRS)

      Ono, Masahiro

      2011-01-01

      Missions to small bodies, such as comets or asteroids, require autonomous guidance for descent to these small bodies. Such guidance is made challenging by uncertainty in the position and velocity of the spacecraft, as well as the uncertainty in the gravitational field around the small body. In addition, the requirement to avoid collision with the asteroid represents a non-convex constraint that means finding the optimal guidance trajectory, in general, is intractable. In this innovation, a new approach is proposed for chance-constrained optimal guidance with non-convex constraints. Chance-constrained guidance takes into account uncertainty so that the probability of collision is below a specified threshold. In this approach, a new bounding method has been developed to obtain a set of decomposed chance constraints that is a sufficient condition of the original chance constraint. The decomposition of the chance constraint enables its efficient evaluation, as well as the application of the branch and bound method. Branch and bound enables non-convex problems to be solved efficiently to global optimality. Considering the problem of finite-horizon robust optimal control of dynamic systems under Gaussian-distributed stochastic uncertainty, with state and control constraints, a discrete-time, continuous-state linear dynamics model is assumed. Gaussian-distributed stochastic uncertainty is a more natural model for exogenous disturbances such as wind gusts and turbulence than the previously studied set-bounded models. However, with stochastic uncertainty, it is often impossible to guarantee that state constraints are satisfied, because there is typically a non-zero probability of having a disturbance that is large enough to push the state out of the feasible region. An effective framework to address robustness with stochastic uncertainty is optimization with chance constraints. These require that the probability of violating the state constraints (i.e., the probability of

    5. Autonomous and cooperative multi-UAV guidance in adversarial environment

      NASA Astrophysics Data System (ADS)

      Zengin, Ugur

      The research presented in this dissertation is aimed at developing rule-based autonomous and cooperative guidance strategies for UAVs to perform missions such as path planning, target tracking and rendezvous while reducing their risk/threat exposure level, and avoiding threats and/or obstacles by utilizing measurement information provided by sensors. First, a mathematical formulation is developed to represent the area of operation that contains various types of threats, obstacles, and restricted areas, in a single framework. Once constructed, there will be no need to distinguish between threats, obstacles and restricted areas as the framework already contains the information on what needs to be avoided and the level of penalty for a given position in the area. This framework provides the mathematical foundation for the guidance strategies to make intelligent decisions during the execution of the mission and also provides scalar metrics to assess the performance of a guidance strategy in a given mission. The autonomous guidance strategies are developed by using a rule-based expert system approach with the requirements of completing assigned mission or task, avoiding obstacle/restricted-areas, minimizing threat exposure level, considering the dynamic and communication constraints of the UAVs and avoiding collision. All these requirements and objectives are quantified and prioritized to facilitate the development of guidance algorithms that can be executed in real-time. The strategies consist of a set of "decision states", which contain rules to determine how the host UAV should move by generating heading and speed signals. Cooperation of multiple UAVs is modeled by minimizing a cost function, which is constructed based on the level of threat exposure for each UAV and distance of each UAV relative to the target. This improves the performance of the system in the terms of increasing the total area of coverage of the sensors onboard the UAVs, increasing the flexibility

    6. Overcoming consumer inertia to dietary guidance.

      PubMed

      Webb, Densie; Byrd-Bredbenner, Carol

      2015-07-01

      Despite 35 y of dietary guidance, there has been no substantial shift in consumer compliance. Consumers report that they seek information on nutrition and healthy eating, but most are not paying attention to dietary recommendations. For guidance to be effective, it must be realistic. Even with increasingly detailed nutrition information and evidence that diet affects health outcomes, convenience and taste remain the strongest determinants of food choices. It is up to health educators to clear up confusion and give consumers control with nutrition messages that are realistic, positive, easy to understand, and actionable without an expectation that consumers will surrender foods they love. PMID:26178023

    7. Development of mining guidance and control systems

      NASA Technical Reports Server (NTRS)

      1979-01-01

      New fundamental interface sensor concepts were identified and investigated including tabulation of the physical and performance characteristics of two new interface detector concepts: - natural background radiation and magnetic spin resonance. Studies of guidance and control techniques for the longwall miner identified three basic systems for use in automated/remote controlled longwall mining. The following projects were initiated: system study which will more completely define the longwall guidance and control system design concepts; integration of the various control functions (vertical, yaw, and roll); and hardware technical requirements.

    8. Virtual Ultrasound Guidance for Inexperienced Operators

      NASA Technical Reports Server (NTRS)

      Caine, Timothy; Martin, David

      2012-01-01

      Medical ultrasound or echocardiographic studies are highly operator-dependent and generally require lengthy training and internship to perfect. To obtain quality echocardiographic images in remote environments, such as on-orbit, remote guidance of studies has been employed. This technique involves minimal training for the user, coupled with remote guidance from an expert. When real-time communication or expert guidance is not available, a more autonomous system of guiding an inexperienced operator through an ultrasound study is needed. One example would be missions beyond low Earth orbit in which the time delay inherent with communication will make remote guidance impractical. The Virtual Ultrasound Guidance system is a combination of hardware and software. The hardware portion includes, but is not limited to, video glasses that allow hands-free, full-screen viewing. The glasses also allow the operator a substantial field of view below the glasses to view and operate the ultrasound system. The software is a comprehensive video program designed to guide an inexperienced operator through a detailed ultrasound or echocardiographic study without extensive training or guidance from the ground. The program contains a detailed description using video and audio to demonstrate equipment controls, ergonomics of scanning, study protocol, and scanning guidance, including recovery from sub-optimal images. The components used in the initial validation of the system include an Apple iPod Classic third-generation as the video source, and Myvue video glasses. Initially, the program prompts the operator to power-up the ultrasound and position the patient. The operator would put on the video glasses and attach them to the video source. After turning on both devices and the ultrasound system, the audio-video guidance would then instruct on patient positioning and scanning techniques. A detailed scanning protocol follows with descriptions and reference video of each view along with

    9. Overcoming Consumer Inertia to Dietary Guidance12

      PubMed Central

      Webb, Densie; Byrd-Bredbenner, Carol

      2015-01-01

      Despite 35 y of dietary guidance, there has been no substantial shift in consumer compliance. Consumers report that they seek information on nutrition and healthy eating, but most are not paying attention to dietary recommendations. For guidance to be effective, it must be realistic. Even with increasingly detailed nutrition information and evidence that diet affects health outcomes, convenience and taste remain the strongest determinants of food choices. It is up to health educators to clear up confusion and give consumers control with nutrition messages that are realistic, positive, easy to understand, and actionable without an expectation that consumers will surrender foods they love. PMID:26178023

    10. Ship motion pattern directed VTOL letdown guidance

      NASA Technical Reports Server (NTRS)

      Phatak, A. V.; Karmali, M. S.; Paulk, C. H., Jr.

      1983-01-01

      This paper examines ship motion pattern directed letdown guidance strategies for landing a VTOL aircraft onboard a small aviation ship under adverse environmental conditions. Off-line computer simulation of the shipboard landing task is utilized for assessing the relative merits of the proposed guidance schemes. A sum of seventy sinusoids representation is used to model the ship motion time histories. The touchdown performance of a nonimal constant-rate-of-descent (CROD) letdown strategy serves as a benchmark for ranking the performance of the alternative letdown schemes.

    11. Aeroassist flight experiment guidance, navigation and control

      NASA Technical Reports Server (NTRS)

      Brand, Timothy J.; Engel, Albert G.

      1986-01-01

      The Aeroassist Flight Experiment scheduled for the early 1990's will demonstrate the use of a low L/D lifting brake using aerodynamic drag to return a spacecraft from a high energy to a low earth orbit. The experimental vehicle will be deployed and retrieved by the Shuttle Orbiter. This paper reviews some of the challenges, problems, and solutions encountered to date during guidance system development, with emphasis on technology advances which will benefit an operational Orbit Transfer Vehicle (OTV). Key factors to be discussed include guidance alternatives, aerodynamic modeling, navigation requirements, the impact of atmospheric uncertainties, and flight profile alternatives considered during initial planning.

    12. CNES Approaching Guidance Experiment within FFIORD

      NASA Technical Reports Server (NTRS)

      Berges, Jean-Claude; Cayeux, Philippe; Gaudel-Vacaresse, Angelique; Meyssignac, Benoit

      2007-01-01

      This article outlines the relative orbit control (guidance algorithm and its preliminary performance tests evaluation) that will be tested by the CNES Team on FFIORD (Formation Flying In Orbit Ranging Demonstration) onboard PRISMA mission. After a brief summary of the PRISMA mission context, the paper provides a full description of the rendezvous function involved in the approaching guidance experiment. This FFIORD onboard function is detailed in terms of on-board algorithmic method (basic algorithm and enhanced alternative), sensibility analysis used to construct maneuver plans and preliminary tests results.

    13. POTW sludge sampling and analysis guidance document

      SciTech Connect

      Not Available

      1989-08-01

      In view of the variability of municipal sludge quality, appropriate procedures must be followed to collect and analyze samples that accurately represent each POTW's sludge quality. The manual was developed to provide that guidance to POTW operators, engineers, managers, chemists and permit writers. It was intended to provide guidance in developing and implementing a sampling and analysis program, to gather information on sludge quality and determine compliance with permit conditions. The manual is based on current, state-of-the-art field and laboratory practices and therefore is recommended for all sludge sampling and analysis programs.

    14. Aerospace plane guidance using geometric control theory

      NASA Technical Reports Server (NTRS)

      Van Buren, Mark A.; Mease, Kenneth D.

      1990-01-01

      A reduced-order method employing decomposition, based on time-scale separation, of the 4-D state space in a 2-D slow manifold and a family of 2-D fast manifolds is shown to provide an excellent approximation to the full-order minimum-fuel ascent trajectory. Near-optimal guidance is obtained by tracking the reduced-order trajectory. The tracking problem is solved as regulation problems on the family of fast manifolds, using the exact linearization methodology from nonlinear geometric control theory. The validity of the overall guidance approach is indicated by simulation.

    15. Ascent guidance algorithm using lidar wind measurements

      NASA Technical Reports Server (NTRS)

      Cramer, Evin J.; Bradt, Jerre E.; Hardtla, John W.

      1990-01-01

      The formulation of a general nonlinear programming guidance algorithm that incorporates wind measurements in the computation of ascent guidance steering commands is discussed. A nonlinear programming (NLP) algorithm that is designed to solve a very general problem has the potential to address the diversity demanded by future launch systems. Using B-splines for the command functional form allows the NLP algorithm to adjust the shape of the command profile to achieve optimal performance. The algorithm flexibility is demonstrated by simulation of ascent with dynamic loading constraints through a set of random wind profiles with and without wind sensing capability.

    16. An analysis of physical guidance as reinforcement for noncompliance.

      PubMed

      Kern, Lee; Delaney, Beth A; Hilt, Alexandra; Bailin, Deborah E; Elliot, Christina

      2002-09-01

      Physical guidance is a strategy commonly used for noncompliance. In two experiments, we evaluated reinforcing effects of physical guidance. Experiment 1 include three individuals with developmental disabilities who were noncompliant with tasks. Anecdotal observations indicated physical contact was highly reinforcing, and a functional analysis identified attention as a reinforcer for problem behavior. Two conditions compared physical guidance following noncompliance and no physical guidance following noncompliance. Results showed noncompliance increased for all three participants when physical guidance followed noncompliance. The second experiment empirically evaluated the function of noncompliance prior to examining the effect of physical guidance on noncompliance. A functional analysis, conducted with two participants, indicated noncompliance served an escape function for one and an attention function for the other. Comparisons of physical guidance and no physical guidance indicated physical guidance resulted in decreased noncompliance for the participant with an escape function but increased noncompliance for the participant with an attention function. PMID:12205825

    17. Intraoperative imaging and fluorescence image guidance in oncologic surgery using a wearable fluorescence goggle system

      NASA Astrophysics Data System (ADS)

      Mondal, Suman B.; Gao, Shengkui; Zhu, Nan; Liu, Yang; Sudlow, Gail P.; Akers, Walter J.; Liang, Rongguang; Gruev, Viktor; Achilefu, Samuel

      2014-03-01

      We have developed a wearable, fluorescence goggle based system for intraoperative imaging of tumors and image guidance in oncologic surgery. Our system can detect fluorescence from cancer selective near infra-red (NIR) contrast agent, facilitating intraoperative visualization of surgical margins and tumors otherwise not apparent to the surgeon. The fluorescence information is displayed directly to the head mounted display (HMD) of the surgeon in real time, allowing unhindered surgical procedure under image guidance. This system has the potential of improving surgical outcomes in oncologic surgery and reduce the chances of cancer recurrence.

    18. Quality assurance guidance for laboratory assessment plates in support of EM environmental sampling and analysis activities

      SciTech Connect

      Not Available

      1994-05-01

      This document is one of several guidance documents developed to support the EM (DOE Environmental Restoration and Waste Management) Analytical Services program. Its purpose is to introduce assessment plates that can be used to conduct performance assessments of an organization`s or project`s ability to meet quality goals for analytical laboratory activities. These assessment plates are provided as non-prescriptive guidance to EM-support organizations responsible for collection of environmental data for remediation and waste management programs at DOE facilities. The assessments evaluate objectively all components of the analytical laboratory process to determine their proper selection and use.

    19. Apollo experience report guidance and control systems: Primary guidance, navigation, and control system development

      NASA Technical Reports Server (NTRS)

      Holley, M. D.; Swingle, W. L.; Bachman, S. L.; Leblanc, C. J.; Howard, H. T.; Biggs, H. M.

      1976-01-01

      The primary guidance, navigation, and control systems for both the lunar module and the command module are described. Development of the Apollo primary guidance systems is traced from adaptation of the Polaris Mark II system through evolution from Block I to Block II configurations; the discussion includes design concepts used, test and qualification programs performed, and major problems encountered. The major subsystems (inertial, computer, and optical) are covered. Separate sections on the inertial components (gyroscopes and accelerometers) are presented because these components represent a major contribution to the success of the primary guidance, navigation, and control system.

    20. A Workable Program of Career Guidance

      ERIC Educational Resources Information Center

      Hunt, Myrtle E.

      1974-01-01

      Seven observations made by a career education team (a counselor, an occupational specialist, and classroom teachers) provided the basis for establishing career guidance goals. The goals were devoloped around the accepted elements of career education and implemented in a teacher-counselor shared accountability effort in Florida's Pinellas County.…

    1. Guidance for performing site inspections under CERCLA

      SciTech Connect

      Not Available

      1992-09-01

      This guidance presents EPA`s site inspection (SI) strategy. The strategy discusses procedural guidelines to investigate potential Superfund (CERCLA) sites for evaluation pursuant to the Hazard Ranking System (HRS), revised in accordance with the Superfund Amendments and Reauthorization Act of 1986. The HRS is the primary means by which EPA evaluates sites for superfund`s National Priorities List (NPL).

    2. Career Guidance and the Kuder Interest Inventories.

      ERIC Educational Resources Information Center

      Science Research Associates, Inc., Chicago, IL.

      The manual suggests various uses the guidance counselor can make of the Kuder interest surveys. Written by a counselor, the guide presents suggestions that reflect considerable experience with the Kuder tests. Guidelines for introducing, administering, and interpreting the instrument are included along with suggestions for ways to involve the…

    3. Advisory List of Instructional Media Guidance.

      ERIC Educational Resources Information Center

      North Carolina State Dept. of Public Instruction, Raleigh.

      A bibliography of materials relevant to the competency-based guidance curriculum of the North Carolina State Department of Public Instruction is presented in this document. Books for students, books for teacher/counselor use, filmstrips (sound), and videocassettes are listed. Grade ranges are provided for each item, although use of the materials…

    4. Guidance and control of flight vehicles

      NASA Technical Reports Server (NTRS)

      Breakwell, J. V.; Bryson, A. E., Jr.; Franklin, G. F.

      1971-01-01

      Progress reports on guidance and attitude control mechanisms of different flight vehicles are presented. The vehicles considered include orbiting spacecraft, supersonic aircraft, and general aviation aircraft. Data also cover orbital transfer using low thrust, automatic landing logic for aircraft, optimal and three dimensional turns for supersonic aircraft, and orbital rendezvous.

    5. Prevocational Exploration Guidance. Competency Based Curriculum.

      ERIC Educational Resources Information Center

      Harrington, Fred; And Others

      This competency-based curriculum for prevocational exploration in West Virginia provides experiences at grades 9 and 10 related to exploring careers and educational programs for those careers. The guidance units are designed to assist the counselor in providing activities that relate to ongoing hands-on activities in prevocational business,…

    6. 75 FR 76011 - Annual Guidance Agenda

      Federal Register 2010, 2011, 2012, 2013, 2014

      2010-12-07

      .... SUPPLEMENTARY INFORMATION: I. Background In the Federal Register of September 19, 2000 (65 FR 56468), FDA issued... existing guidance documents (65 FR 56468 at 56477; 21 CFR 10.115(f)(5)). The Agency is neither bound by... Administration, and Alkaline Phosphatase Activity 5100 Paint Branch Pkwy, (Compliance Policy Guide...

    7. Guidance and Counseling Research in New Zealand.

      ERIC Educational Resources Information Center

      Small, J. J.

      This review of guidance and counseling research includes reports of hypothesis testing based on hard data and behavioral analysis designs, reports of surveys and evaluations, and comments and recommenda- tions from reflections on experience and survey findings. The materials, originating from New Zealand between 1970 and 1979, are classified on…

    8. 21 CFR 601.29 - Guidance documents.

      Code of Federal Regulations, 2011 CFR

      2011-04-01

      ... for Biologics Evaluation and Research (CBER) maintains a list of guidance documents that apply to the... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS... Manufacturers Assistance (HFM-40), Center for Biologics Evaluation and Research, Food and Drug...

    9. 21 CFR 314.445 - Guidance documents.

      Code of Federal Regulations, 2010 CFR

      2010-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG Miscellaneous Provisions § 314.445 Guidance... comply with certain requirements of this part. (b) The Center for Drug Evaluation and Research...

    10. 21 CFR 601.29 - Guidance documents.

      Code of Federal Regulations, 2013 CFR

      2013-04-01

      ... for Biologics Evaluation and Research (CBER) maintains a list of guidance documents that apply to the... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS... Manufacturers Assistance (HFM-40), Center for Biologics Evaluation and Research, Food and Drug...

    11. 21 CFR 314.445 - Guidance documents.

      Code of Federal Regulations, 2013 CFR

      2013-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG Miscellaneous Provisions § 314.445 Guidance... comply with certain requirements of this part. (b) The Center for Drug Evaluation and Research...

    12. 21 CFR 314.445 - Guidance documents.

      Code of Federal Regulations, 2014 CFR

      2014-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG Miscellaneous Provisions § 314.445 Guidance... comply with certain requirements of this part. (b) The Center for Drug Evaluation and Research...

    13. 21 CFR 314.445 - Guidance documents.

      Code of Federal Regulations, 2012 CFR

      2012-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG Miscellaneous Provisions § 314.445 Guidance... comply with certain requirements of this part. (b) The Center for Drug Evaluation and Research...

    14. 21 CFR 601.29 - Guidance documents.

      Code of Federal Regulations, 2014 CFR

      2014-04-01

      ... for Biologics Evaluation and Research (CBER) maintains a list of guidance documents that apply to the... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS... Manufacturers Assistance (HFM-40), Center for Biologics Evaluation and Research, Food and Drug...

    15. 21 CFR 601.29 - Guidance documents.

      Code of Federal Regulations, 2012 CFR

      2012-04-01

      ... for Biologics Evaluation and Research (CBER) maintains a list of guidance documents that apply to the... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS... Manufacturers Assistance (HFM-40), Center for Biologics Evaluation and Research, Food and Drug...

    16. 21 CFR 314.445 - Guidance documents.

      Code of Federal Regulations, 2011 CFR

      2011-04-01

      ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG Miscellaneous Provisions § 314.445 Guidance... comply with certain requirements of this part. (b) The Center for Drug Evaluation and Research...

    17. Museum Personnel's Opinions on Mobile Guidance Systems

      ERIC Educational Resources Information Center

      Yoshimura, Hirokazu; Sekiguchi, Hiromi; Yabumoto, Yoshitaka

      2007-01-01

      While opinions from the general public are certainly important, opinions from the museum staff are also necessary to improve user service systems. this article introduces two groups of museum staff who have evaluated the usability of mobile guidance systems in Japanese museums. One group is the research team who used the PDA system in the National…

    18. IUS guidance algorithm gamma guide assessment

      NASA Technical Reports Server (NTRS)

      Bray, R. E.; Dauro, V. A.

      1980-01-01

      The Gamma Guidance Algorithm which controls the inertial upper stage is described. The results of an independent assessment of the algorithm's performance in satisfying the NASA missions' targeting objectives are presented. The results of a launch window analysis for a Galileo mission, and suggested improvements are included.

    19. Vocational Guidance for Women, 1910-1940.

      ERIC Educational Resources Information Center

      Rossiter, Margaret W.

      The kinds of vocational guidance available to women from 1910 to 1940 are discussed in this paper. As the number of women college graduates increased in the 1890s and especially in the first decade of the 20th century, concern also grew for what all these trained women would do to earn a living after they graduated and before they married (if they…

    20. Occupational Information. A Career Guidance View.

      ERIC Educational Resources Information Center

      Wolfbein, Seymour L.

      This book deals not with the administrative or information searching processes related to the guidance function of providing occupational information, but with the substantive information itself. It presents a contemporary view of values, trends, and principles, derived primarily from statistical information describing the current world of work.…