Science.gov

Sample records for address delete entry

  1. Personalized exon skipping strategies to address clustered non-deletion dystrophin mutations.

    PubMed

    Forrest, Sarah; Meloni, Penny L; Muntoni, Francesco; Kim, Jihee; Fletcher, Sue; Wilton, Steve D

    2010-12-01

    Antisense oligomer induced exon skipping is showing promise as a therapy to reduce the severity of Duchenne muscular dystrophy. To date, the focus has been on excluding single exons flanking frame-shifting deletions in the dystrophin gene. However, a third of all Duchenne muscular dystrophy causing mutations are more subtle DNA changes. Thirty nine dystrophin exons are potentially frame-shifting and mutations in these will require the targeted removal of exon blocks to generate in-frame transcripts. We report that clustered non-deletion mutations in the dystrophin gene respond differently to different antisense oligomer preparations targeting the same dual exon block, the removal of which bypasses the mutation and restores the open reading-frame. The personalized nature of the responses to antisense oligomer application presents additional challenges to the induction of multi-exon skipping with a single oligomer preparation.

  2. Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons

    PubMed Central

    Jambunathan, Nithya; Charles, Anu-Susan; Subramanian, Ramesh; Saied, Ahmad A.; Naderi, Misagh; Rider, Paul; Brylinski, Michal; Chouljenko, Vladimir N.

    2015-01-01

    ABSTRACT We have shown previously that herpes simplex virus 1 (HSV-1) lacking expression of the entire glycoprotein K (gK) or expressing gK with a 38-amino-acid deletion (gKΔ31–68 mutation) failed to infect ganglionic neurons after ocular infection of mice. We constructed a new model for the predicted three-dimensional structure of gK, revealing that the gKΔ31–68 mutation spans a well-defined β-sheet structure within the amino terminus of gK, which is conserved among alphaherpesviruses. The HSV-1(McKrae) gKΔ31–68 virus was tested for the ability to enter into ganglionic neuronal axons in cell culture of explanted rat ganglia using a novel virus entry proximity ligation assay (VEPLA). In this assay, cell surface-bound virions were detected by the colocalization of gD and its cognate receptor nectin-1 on infected neuronal surfaces. Capsids that have entered into the cytoplasm were detected by the colocalization of the virion tegument protein UL37, with dynein required for loading of virion capsids onto microtubules for retrograde transport to the nucleus. HSV-1(McKrae) gKΔ31–68 attached to cell surfaces of Vero cells and ganglionic axons in cell culture as efficiently as wild-type HSV-1(McKrae). However, unlike the wild-type virus, the mutant virus failed to enter into the axoplasm of ganglionic neurons. This work suggests that the amino terminus of gK is a critical determinant for entry into neuronal axons and may serve similar conserved functions for other alphaherpesviruses. IMPORTANCE Alphaherpesviruses, unlike beta- and gammaherpesviruses, have the unique ability to infect and establish latency in neurons. Glycoprotein K (gK) and the membrane protein UL20 are conserved among all alphaherpesviruses. We show here that a predicted β-sheet domain, which is conserved among alphaherpesviruses, functions in HSV-1 entry into neuronal axons, suggesting that it may serve similar functions for other herpesviruses. These results are in agreement with our

  3. Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation

    PubMed Central

    Chen, Jin; Li, Zhaozhong; Hatcher, Jeffery T.; Chen, Qing-Hui; Chen, Li; Wurster, Robert D.; Chan, Sic L.; Cheng, Zixi

    2017-01-01

    Transient receptor potential canonical 6 (TRPC6) channels are permeable to Na+ and Ca2+ and are widely expressed in the brain. In this study, the role of TRPC6 was investigated following ischemia/reperfusion (I/R) and oxygen-glucose deprivation (OGD). We found that TRPC6 expression was increased in wild-type (WT) mice cortical neurons following I/R and in primary neurons with OGD, and that deletion of TRPC6 reduced the I/R-induced brain infarct in mice and the OGD- /neurotoxin-induced neuronal death. Using live-cell imaging to examine intracellular Ca2+ levels ([Ca2+]i), we found that OGD induced a significant higher increase in glutamate-evoked Ca2+ influx compared to untreated control and such an increase was reduced by TRPC6 deletion. Enhancement of TRPC6 expression using AdCMV-TRPC6-GFP infection in WT neurons increased [Ca2+]i in response to glutamate application compared to AdCMV-GFP control. Inhibition of N-methyl-d-aspartic acid receptor (NMDAR) with MK801 decreased TRPC6-dependent increase of [Ca2+]i in TRPC6 infected cells, indicating that such a Ca2+ influx was NMDAR dependent. Furthermore, TRPC6-dependent Ca2+ influx was blunted by blockade of Na+ entry in TRPC6 infected cells. Finally, OGD-enhanced Ca2+ influx was reduced, but not completely blocked, in the presence of voltage-dependent Na+ channel blocker tetrodotoxin (TTX) and dl-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) blocker CNQX. Altogether, we concluded that I/R-induced brain damage was, in part, due to upregulation of TRPC6 in cortical neurons. We postulate that overexpression of TRPC6 following I/R may induce neuronal death partially through TRPC6-dependent Na+ entry which activated NMDAR, thus leading to a damaging Ca2+ overload. These findings may provide a potential target for future intervention in stroke-induced brain damage.

  4. Modulated Entry

    NASA Technical Reports Server (NTRS)

    Grant, Frederick C.

    1960-01-01

    The technique of modulation, or variable coefficients, is discussed and the analytical formulation is reviewed. Representative numerical results of the use of modulation are shown for the lifting and nonlifting cases. These results include the effects of modulation on peak acceleration, entry corridor, and heat absorption. Results are given for entry at satellite speed and escape speed. The indications are that coefficient modulation on a vehicle with good lifting capability offers the possibility of sizable loading reductions or, alternatively, wider corridors; thus, steep entries become practical from the loading standpoint. The amount of steepness depends on the acceptable heating penalty. The price of sizable fractions of the possible gains does not appear to be excessive.

  5. 19 CFR 142.49 - Deletion of C-4 Code.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... with any justification and without prior notification in cases of willfulness or when public health... 19 Customs Duties 2 2011-04-01 2011-04-01 false Deletion of C-4 Code. 142.49 Section 142.49... TREASURY (CONTINUED) ENTRY PROCESS Line Release § 142.49 Deletion of C-4 Code. (a) By Customs. A...

  6. 19 CFR 142.49 - Deletion of C-4 Code.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... with any justification and without prior notification in cases of willfulness or when public health... 19 Customs Duties 2 2012-04-01 2012-04-01 false Deletion of C-4 Code. 142.49 Section 142.49... TREASURY (CONTINUED) ENTRY PROCESS Line Release § 142.49 Deletion of C-4 Code. (a) By Customs. A...

  7. 19 CFR 142.49 - Deletion of C-4 Code.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... with any justification and without prior notification in cases of willfulness or when public health... 19 Customs Duties 2 2013-04-01 2013-04-01 false Deletion of C-4 Code. 142.49 Section 142.49... TREASURY (CONTINUED) ENTRY PROCESS Line Release § 142.49 Deletion of C-4 Code. (a) By Customs. A...

  8. AFMLTA 19th Biennial Conference Horwood Address: Accomplished Teaching of Languages and Cultures Doesn't Happen by Chance: Reflective Journal Entries of a "Returnee" to the Learner Seat

    ERIC Educational Resources Information Center

    Harbon, Lesley

    2014-01-01

    The following is the text of the Horwood Address delivered by Associate Professor Lesley Harbon from the University of Sydney at the AFMLTA Biennial Conference in Canberra 2013. The focus of the Address is accomplished teaching of languages and cultures, known to us all through the AFMLTA's work on Professional Standards published in 2005.…

  9. GOCE Re-Entry Campaign

    NASA Astrophysics Data System (ADS)

    Bastida, B.; Flohrer, T.; Lemmens, S.; Krag, H.

    2015-03-01

    Every year ESA, through the Space Debris Office, participates to an Inter-Agency Space Debris Coordination Committee (IADC) Re-entry Test Campaign.. For the campaign of 2013, ESA’s proposal to select GOCE's re-entry was accepted. The campaign opened on the 21st October 2013 after fuel depletion of the drag-compensating ion propulsion. GOCE was expected to enter into a phase of attitude-controlled fine-pointing mode (FPM) until the attitude controllers would be unable to cope with the atmospheric torques and then the satellite would enter in a phase of fully uncontrolled flight. In this paper, we present the evolution of ESA’s daily predictions on the re-entry epoch using different sources of orbital information. The uncertainties on the spacecraft operability (i.e. the physical limits of the attitude controller) led to a non-standard re-entry scenario were different attitudes had to be considered (instead of the commonly assumed random tumbling mode case that is used whenever no information on the physical properties of a re-entering object is available). A daily assessment of the status, in coordination with the flight control team, was required and implied a continuous update on the predicted failure point of the attitude controller. This in turn imposed the need for considering an asymmetric re-entry window. These operation-bound uncertainties were simulated to predict the attitude evolution after failure at different altitudes and their effects evaluated to be taken into account for the re-entry predictions. We present ESA’s re-entry prediction activities for GOCE, internally, and within the IADC, and address specific technical aspects and challenges for re-entry predictions, which are related to the expected and occurred attitude of GOCE during the final re-entry phase.

  10. Orion Entry Handling Qualities Assessments

    NASA Technical Reports Server (NTRS)

    Bihari, B.; Tiggers, M.; Strahan, A.; Gonzalez, R.; Sullivan, K.; Stephens, J. P.; Hart, J.; Law, H., III; Bilimoria, K.; Bailey, R.

    2011-01-01

    The Orion Command Module (CM) is a capsule designed to bring crew back from the International Space Station (ISS), the moon and beyond. The atmospheric entry portion of the flight is deigned to be flown in autopilot mode for nominal situations. However, there exists the possibility for the crew to take over manual control in off-nominal situations. In these instances, the spacecraft must meet specific handling qualities criteria. To address these criteria two separate assessments of the Orion CM s entry Handling Qualities (HQ) were conducted at NASA s Johnson Space Center (JSC) using the Cooper-Harper scale (Cooper & Harper, 1969). These assessments were conducted in the summers of 2008 and 2010 using the Advanced NASA Technology Architecture for Exploration Studies (ANTARES) six degree of freedom, high fidelity Guidance, Navigation, and Control (GN&C) simulation. This paper will address the specifics of the handling qualities criteria, the vehicle configuration, the scenarios flown, the simulation background and setup, crew interfaces and displays, piloting techniques, ratings and crew comments, pre- and post-fight briefings, lessons learned and changes made to improve the overall system performance. The data collection tools, methods, data reduction and output reports will also be discussed. The objective of the 2008 entry HQ assessment was to evaluate the handling qualities of the CM during a lunar skip return. A lunar skip entry case was selected because it was considered the most demanding of all bank control scenarios. Even though skip entry is not planned to be flown manually, it was hypothesized that if a pilot could fly the harder skip entry case, then they could also fly a simpler loads managed or ballistic (constant bank rate command) entry scenario. In addition, with the evaluation set-up of multiple tasks within the entry case, handling qualities ratings collected in the evaluation could be used to assess other scenarios such as the constant bank angle

  11. Addressing healthcare.

    PubMed

    Daly, Rich

    2013-02-11

    Though President Barack Obama has rarely made healthcare references in his State of the Union addresses, health policy experts are hoping he changes that strategy this year. "The question is: Will he say anything? You would hope that he would, given that that was the major issue he started his presidency with," says Dr. James Weinstein, left, of the Dartmouth-Hitchcock health system.

  12. Schizophrenia and chromosomal deletions

    SciTech Connect

    Lindsay, E.A.; Baldini, A.; Morris, M. A.

    1995-06-01

    Recent genetic linkage analysis studies have suggested the presence of a schizophrenia locus on the chromosomal region 22q11-q13. Schizophrenia has also been frequently observed in patients affected with velo-cardio-facial syndrome (VCFS), a disorder frequently associated with deletions within 22q11.1. It has been hypothesized that psychosis in VCFS may be due to deletion of the catechol-o-methyl transferase gene. Prompted by these observations, we screened for 22q11 deletions in a population of 100 schizophrenics selected from the Maryland Epidemiological Sample. Our results show that there are schizophrenic patients carrying a deletion of 22q11.1 and a mild VCFS phenotype that might remain unrecognized. These findings should encourage a search for a schizophrenia-susceptibility gene within the deleted region and alert those in clinical practice to the possible presence of a mild VCFS phenotype associated with schizophrenia. 9 refs.

  13. Orthopoxvirus species and strain differences in cell entry

    SciTech Connect

    Bengali, Zain; Satheshkumar, P.S.; Moss, Bernard

    2012-11-25

    Vaccinia virus (VACV) enters cells by a low pH endosomal route or by direct fusion with the plasma membrane. We previously found differences in entry properties of several VACV strains: entry of WR was enhanced by low pH, reduced by bafilomycin A1 and relatively unaffected by heparin, whereas entry of IHD-J, Copenhagen and Elstree were oppositely affected. Since binding and entry modes may have been selected by specific conditions of in vitro propagation, we now examined the properties of three distinct, recently isolated cowpox viruses and a monkeypox virus as well as additional VACV and cowpox virus strains. The recent isolates were more similar to WR than to other VACV strains, underscoring the biological importance of endosomal entry by orthopoxviruses. Sequence comparisons, gene deletions and gene swapping experiments indicated that viral determinants, other than or in addition to the A26 and A25 'fusion-suppressor' proteins, impact entry properties.

  14. Technology for Entry Probes

    NASA Technical Reports Server (NTRS)

    Cutts, James A.; Arnold, James; Venkatapathy, Ethiraj; Kolawa, Elizabeth; Munk, Michelle; Wercinski, Paul; Laub, Bernard

    2005-01-01

    A viewgraph describing technologies for entry probes is presented. The topics include: 1) Entry Phase; 2) Descent Phase; 3) Long duration atmospheric observations; 4) Survivability at high temperatures; and 5) Summary.

  15. 78 FR 53733 - Procurement List Additions and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List Additions and Deletions AGENCY: Committee for Purchase from People Who are Blind or Severely Disabled. ACTION: Additions to and Deletions from the...: September 30, 2013. ADDRESSES: Committee for Purchase From People Who Are Blind or Severely Disabled, 1401...

  16. 76 FR 29209 - Procurement List Additions and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List Additions and Deletions AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Additions to and deletions from the.... ADDRESSES: Committee for Purchase From People Who Are Blind or Severely Disabled, Jefferson Plaza 2,...

  17. 49 CFR 380.503 - Entry-level driver training requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Entry-level driver training requirements. 380.503... SPECIAL TRAINING REQUIREMENTS Entry-Level Driver Training Requirements § 380.503 Entry-level driver training requirements. Entry-level driver training must include instruction addressing the following...

  18. 49 CFR 380.503 - Entry-level driver training requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Entry-level driver training requirements. 380.503... SPECIAL TRAINING REQUIREMENTS Entry-Level Driver Training Requirements § 380.503 Entry-level driver training requirements. Entry-level driver training must include instruction addressing the following...

  19. Inaugural address

    NASA Astrophysics Data System (ADS)

    Joshi, P. S.

    2014-03-01

    From jets to cosmos to cosmic censorship P S Joshi Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India E-mail: psj@tifr.res.in 1. Introduction At the outset, I should like to acknowledge that part of the title above, which tries to capture the main flavour of this meeting, and has been borrowed from one of the plenary talks at the conference. When we set out to make the programme for the conference, we thought of beginning with observations on the Universe, but then we certainly wanted to go further and address deeper questions, which were at the very foundations of our inquiry, and understanding on the nature and structure of the Universe. I believe, we succeeded to a good extent, and it is all here for you in the form of these Conference Proceedings, which have been aptly titled as 'Vishwa Mimansa', which could be possibly translated as 'Analysis of the Universe'! It is my great pleasure and privilege to welcome you all to the ICGC-2011 meeting at Goa. The International Conference on Gravitation and Cosmology (ICGC) series of meetings are being organized by the Indian Association for General Relativity and Gravitation (IAGRG), and the first such meeting was planned and conducted in Goa in 1987, with subsequent meetings taking place at a duration of about four years at various locations in India. So, it was thought appropriate to return to Goa to celebrate the 25 years of the ICGC meetings. The recollections from that first meeting have been recorded elsewhere here in these Proceedings. The research and teaching on gravitation and cosmology was initiated quite early in India, by V V Narlikar at the Banares Hindu University, and by N R Sen in Kolkata in the 1930s. In course of time, this activity grew and gained momentum, and in early 1969, at the felicitation held for the 60 years of V V Narlikar at a conference in Ahmedabad, P C Vaidya proposed the formation of the IAGRG society, with V V Narlikar being the first President. This

  20. Convocation address.

    PubMed

    Kakodkar, A

    1999-07-01

    This convocation addressed by Dr. Anil Kakodkar focuses on the challenges faced by graduating students. In his speech, he emphasized the high level of excellence achieved by the industrial sector; however, he noted that there has been a loss of initiative in maximizing value addition, which was worsened by an increasing population pressure. In facing a stiff competition in the external and domestic markets, it is imperative to maximize value addition within the country in a competitive manner and capture the highest possible market share. To achieve this, high-quality human resources are central. Likewise, family planning programs should become more effective and direct available resources toward national advantage. To boost the domestic market, he suggests the need to search for strengths to achieve leadership position in those areas. First, an insight into the relationship between the lifestyles and the needs of our people and the natural resource endowment must be gained. Second, remodeling of the education system must be undertaken to prepare the people for adding the necessary innovative content in our value addition activities. Lastly, Dr. Kakodkar emphasizes the significance of developing a strong bond between parents and children to provide a sound foundation and allow the education system to grow upon it.

  1. Clinical data entry.

    PubMed Central

    van Mulligen, E. M.; Stam, H.; van Ginneken, A. M.

    1998-01-01

    Routine capture of patient data for a computer-based patient record system remains a subject of study. Time constraints that require fast data entry and maximal expression power are in favor of free text data entry. However, using patient data directly for decision support systems, for quality assessment, etc. requires structured data entry, which appears to be more tedious and time consuming. In this paper, a prototype clinical data entry application is described that combines free text and structured data entry in one single application and allows clinicians to smoothly switch between these two different input styles. A knowledge base involving a semantic network of clinical data entry terms and their properties and relationships is used by this application to support structured data entry. From structured data, sentences are generated and shown in a text processor together with the free text. This presentation metaphor allows for easy integrated presentation of structured data and free text. Images Figure 1 Figure 2 PMID:9929186

  2. Opening Address

    NASA Astrophysics Data System (ADS)

    Yamada, T.

    2014-12-01

    Ladies and Gentlemen, it is my great honor and pleasure to present an opening address of the 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3). On the behalf of the organizing committee, I certainly welcome all your visits to KGU Kannai Media Center belonging to Kanto Gakuin University, and stay in Yokohama. In particular, to whom come from abroad more than 17 countries, I would appreciate your participations after long long trips from your homeland to Yokohama. The first international workshop on "State of the Art in Nuclear Cluster Physics", called SOTANCP, was held in Strasbourg, France, in 2008, and the second one was held in Brussels, Belgium, in 2010. Then the third workshop is now held in Yokohama. In this period, we had the traditional 10th cluster conference in Debrecen, Hungary, in 2012. Thus we have the traditional cluster conference and SOTANCP, one after another, every two years. This obviously shows our field of nuclear cluster physics is very active and flourishing. It is for the first time in about 10 years to hold the international workshop on nuclear cluster physics in Japan, because the last cluster conference held in Japan was in Nara in 2003, about 10 years ago. The president in Nara conference was Prof. K. Ikeda, and the chairpersons were Prof. H. Horiuchi and Prof. I. Tanihata. I think, quite a lot of persons in this room had participated at the Nara conference. Since then, about ten years passed. So, this workshop has profound significance for our Japanese colleagues. The subjects of this workshop are to discuss "the state of the art in nuclear cluster physics" and also discuss the prospect of this field. In a couple of years, we saw significant progresses of this field both in theory and in experiment, which have brought better and new understandings on the clustering aspects in stable and unstable nuclei. I think, the concept of clustering has been more important than ever. This is true also in the

  3. Presidential address.

    PubMed

    Vohra, U

    1993-07-01

    The Secretary of India's Ministry of Health and Family Welfare serves as Chair of the Executive Council of the International Institute for Population Sciences in Bombay. She addressed its 35th convocation in 1993. Global population stands at 5.43 billion and increases by about 90 million people each year. 84 million of these new people are born in developing countries. India contributes 17 million new people annually. The annual population growth rate in India is about 2%. Its population size will probably surpass 1 billion by the 2000. High population growth rates are a leading obstacle to socioeconomic development in developing countries. Governments of many developing countries recognize this problem and have expanded their family planning programs to stabilize population growth. Asian countries that have done so and have completed the fertility transition include China, Japan, Singapore, South Korea, and Thailand. Burma, Malaysia, North Korea, Sri Lanka, and Vietnam have not yet completed the transition. Afghanistan, Bangladesh, Iran, Nepal, and Pakistan are half-way through the transition. High population growth rates put pressure on land by fragmenting finite land resources, increasing the number of landless laborers and unemployment, and by causing considerable rural-urban migration. All these factors bring about social stress and burden civic services. India has reduced its total fertility rate from 5.2 to 3.9 between 1971 and 1991. Some Indian states have already achieved replacement fertility. Considerable disparity in socioeconomic development exists among states and districts. For example, the states of Bihar, Madhya Pradesh, Rajasthan, and Uttar Pradesh have female literacy rates lower than 27%, while that for Kerala is 87%. Overall, infant mortality has fallen from 110 to 80 between 1981 and 1990. In Uttar Pradesh, it has fallen from 150 to 98, while it is at 17 in Kerala. India needs innovative approaches to increase contraceptive prevalence rates

  4. Welcome Address

    NASA Astrophysics Data System (ADS)

    Kiku, H.

    2014-12-01

    Ladies and Gentlemen, It is an honor for me to present my welcome address in the 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3), as the president of Kanto Gakuin University. Particularly to those from abroad more than 17 countries, I am very grateful for your participation after long long trips from your home to Yokohama. On the behalf of the Kanto Gakuin University, we certainly welcome your visit to our university and stay in Yokohama. First I would like to introduce Kanto Gakuin University briefly. Kanto Gakuin University, which is called KGU, traces its roots back to the Yokohama Baptist Seminary founded in 1884 in Yamate, Yokohama. The seminary's founder was Albert Arnold Bennett, alumnus of Brown University, who came to Japan from the United States to establish a theological seminary for cultivating and training Japanese missionaries. Now KGU is a major member of the Kanto Gakuin School Corporation, which is composed of two kindergartens, two primary schools, two junior high schools, two senior high schools as well as KGU. In this university, we have eight faculties with graduate school including Humanities, Economics, Law, Sciences and Engineering, Architecture and Environmental Design, Human and Environmental Studies, Nursing, and Law School. Over eleven thousands students are currently learning in our university. By the way, my major is the geotechnical engineering, and I belong to the faculty of Sciences and Engineering in my university. Prof. T. Yamada, here, is my colleague in the same faculty. I know that the nuclear physics is one of the most active academic fields in the world. In fact, about half of the participants, namely, more than 50 scientists, come from abroad in this conference. Moreover, I know that the nuclear physics is related to not only the other fundamental physics such as the elementary particle physics and astrophysics but also chemistry, medical sciences, medical cares, and radiation metrology

  5. Entry at Venus

    NASA Technical Reports Server (NTRS)

    Venkatapathy, Ethiraj; Smith, Brandon

    2016-01-01

    This is lecture to be given at the IPPW 2016, as part of the 2 day course on Short Course on Destination Venus: Science, Technology and Mission Architectures. The attached presentation material is intended to be introduction to entry aspects of Venus in-situ robotic missions. The presentation introduces the audience to the aerodynamic and aerothermodynamic aspects as well as the loads, both aero and thermal, generated during entry. The course touches upon the system design aspects such as TPS design and both high and low ballistic coefficient entry system concepts that allow the science payload to be protected from the extreme entry environment and yet meet the mission objectives.

  6. Adding and Deleting Images

    EPA Pesticide Factsheets

    Images are added via the Drupal WebCMS Editor. Once an image is uploaded onto a page, it is available via the Library and your files. You can edit the metadata, delete the image permanently, and/or replace images on the Files tab.

  7. Stardust Entry Reconstruction

    NASA Technical Reports Server (NTRS)

    Desai, Prasun N.; Qualls, Garry D.

    2008-01-01

    An overview of the reconstruction analyses performed for the Stardust capsule entry is described. The results indicate that the actual entry was very close to the pre-entry predictions. The capsule landed 8.1 km north-northwest of the desired target at Utah Test and Training Range. Analyses of infrared video footage and radar range data (obtained from tracking stations) during the descent show that drogue parachute deployment was 4.8 s later than the pre-entry prediction, while main parachute deployment was 19.3 s earlier than the pre-set timer indicating that main deployment was actually triggered by the backup baroswitch. Reconstruction of a best estimated trajectory revealed that the aerodynamic drag experienced by the capsule during hypersonic flight was within 1% of pre-entry predications. Observations of the heatshield support the pre-entry estimates of small hypersonic angles of attack, since there was very little, if any, charring of the shoulder region or the aftbody. Through this investigation, an overall assertion can be made that all the data gathered from the Stardust capsule entry were consistent with flight performance close to nominal pre-entry predictions. Consequently, the design principles and methodologies utilized for the flight dynamics, aerodynamics, and aerothermodynamics analyses have been corroborated.

  8. Deletion (2)(q37)

    SciTech Connect

    Stratton, R.F.; Tolworthy, J.A.; Young, R.S.

    1994-06-01

    We report on a 5-month-old girl with widely spaced nipples, redundant nuchal skin, coarctation of the aorta, anal atresia with distal fistula, postnatal growth retardation, hypotonia, and sparse scalp hair. Initial clinical assessment suggested the diagnosis of Ullrich-Turner syndrome. Chromosome analysis showed a 46,XX,del(2)(q37) karyotype in peripheral lymphocytes. We compare her findings to those of other reported patients with terminal deletions of 2q. 8 refs., 2 figs., 1 tab.

  9. Orion Entry Monitor

    NASA Technical Reports Server (NTRS)

    Smith, Kelly M.

    2016-01-01

    NASA is scheduled to launch the Orion spacecraft atop the Space Launch System on Exploration Mission 1 in late 2018. When Orion returns from its lunar sortie, it will encounter Earth's atmosphere with speeds in excess of 11 kilometers per second, and Orion will attempt its first precision-guided skip entry. A suite of flight software algorithms collectively called the Entry Monitor has been developed in order to enhance crew situational awareness and enable high levels of onboard autonomy. The Entry Monitor determines the vehicle capability footprint in real-time, provides manual piloting cues, evaluates landing target feasibility, predicts the ballistic instantaneous impact point, and provides intelligent recommendations for alternative landing sites if the primary landing site is not achievable. The primary engineering challenges of the Entry Monitor is in the algorithmic implementation in making a highly reliable, efficient set of algorithms suitable for onboard applications.

  10. Worldwide growth market forecast for re-entry drilling

    SciTech Connect

    1996-10-01

    Operators worldwide hail re-entry drilling as the fastest growing development technique in the business. With re-entry technology advancing on a number of fronts, the only question seems to be which re-entry technique is best to get optimum well productivity. Discussions now address how best to proceed: traditional re-entry (RED), coiled tubing drilling (CTD) or short radius (SRD). New technology is definitely fueling a methodology shift in favor of coiled tubing drilling and short radius drilling. Petroleum Engineer International explored the booming re-entry business with operators from the North Sea and North American markets. The paper contains the operators` thoughts on re-entry drilling.

  11. Optimizing TLB entries for mixed page size storage in contiguous memory

    DOEpatents

    Chen, Dong; Gara, Alan; Giampapa, Mark E.; Heidelberger, Philip; Kriegel, Jon K.; Ohmacht, Martin; Steinmacher-Burow, Burkhard

    2013-04-30

    A system and method for accessing memory are provided. The system comprises a lookup buffer for storing one or more page table entries, wherein each of the one or more page table entries comprises at least a virtual page number and a physical page number; a logic circuit for receiving a virtual address from said processor, said logic circuit for matching the virtual address to the virtual page number in one of the page table entries to select the physical page number in the same page table entry, said page table entry having one or more bits set to exclude a memory range from a page.

  12. Shuttle entry guidance

    NASA Technical Reports Server (NTRS)

    Harpold, J. C.; Graves, C. A., Jr.

    1978-01-01

    This paper describes the design of the entry guidance for the Space Shuttle Orbiter. This guidance provides the steering commands for trajectory control from initial penetration of the earth's atmosphere until the terminal area guidance is activated at an earth-relative speed of 2500 fps. At this point, the Orbiter is at a distance of about 50 nmi from the runway threshold, and at an altitude of about 80,000 ft. The entry guidance design is based on an analytic solution of the equations of motion defining the drag acceleration profile that meets the terminal criteria of the entry flight while maintaining the flight within systems and operational constraints. Guidance commands, which are based on a control law that ensures damping of oscillatory type trajectory motion, are computed to steer the Orbiter to this drag acceleration profile.

  13. Orbiter entry aerothermodynamics

    NASA Technical Reports Server (NTRS)

    Ried, R. C.

    1985-01-01

    The challenge in the definition of the entry aerothermodynamic environment arising from the challenge of a reliable and reusable Orbiter is reviewed in light of the existing technology. Select problems pertinent to the orbiter development are discussed with reference to comprehensive treatments. These problems include boundary layer transition, leeward-side heating, shock/shock interaction scaling, tile gap heating, and nonequilibrium effects such as surface catalysis. Sample measurements obtained from test flights of the Orbiter are presented with comparison to preflight expectations. Numerical and wind tunnel simulations gave efficient information for defining the entry environment and an adequate level of preflight confidence. The high quality flight data provide an opportunity to refine the operational capability of the orbiter and serve as a benchmark both for the development of aerothermodynamic technology and for use in meeting future entry heating challenges.

  14. Mobile physician order entry.

    PubMed

    Ying, Alan

    2003-01-01

    Because both computerized physician order entry (CPOE) systems and mobile technologies such as handheld devices have the potential to greatly impact the industry's future, IT vendors, hospitals, and clinicians are simply merging them into a logical convergence--"CPOE on a handheld"--with an expectation of full functionality on all platforms: computer workstations, rolling laptops, tablet PCs, and handheld devices. For these trends to succeed together, however, this expectation must be revised to establish a distinct category--mobile physician order entry (MPOE)--that is different from CPOE in form, function, and implementation.

  15. Atmospheric Entry Studies for Uranus

    NASA Technical Reports Server (NTRS)

    Agrawal, Parul; Allen, Gary A.; Hwang, Helen; Prabhu, Dinesh; Aliaga, Jose; Marley, Mark; McGuire, Kathy; Huynh, Loc; Garcia, Joseph; Moses, Robert; Winski, Rick; Skylanskiy, Evgeniy

    2013-01-01

    The Objectives of this work are: 1) Establish a range of probe atmospheric entry environments based on the Uranus Flagship mission outlined in the Planetary Science Decadal Survey for two launch windows: Year 2021 and 2034. 2) Define Uranus entry trade space by performing parametric studies, by varying vehicle mass and size and entry Flight Path Angle (FPA). 3) Investigate various trajectory options, including direct ballistic entry and aero-capture entry. 4) Identify entry technologies that could be leveraged to enable a viable mission to Uranus that meets science objectives.

  16. Think Exit at Entry

    ERIC Educational Resources Information Center

    O'Rourke, Tom; Satterfield, Coy E.

    2005-01-01

    This paper describes the "Think Exit at Entry" program that has become the guiding principle for the Georgia Department of Juvenile Justice (DJJ). The Georgia DJJ believes that the transition process begins the day the youth enters the system and continues well after release from the institution. Literature points the need for transition…

  17. 9. FIRST FLOOR, ENTRY HALL, LOOKING SOUTHWEST TOWARDS FRONT ENTRY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. FIRST FLOOR, ENTRY HALL, LOOKING SOUTHWEST TOWARDS FRONT ENTRY WITH OPEN DOORWAY TO WINDER STAIRWAY ON RIGHT - Open Gate Farm, House, Ridge Road, 1 mile East of Elephant Road, Perkasie, Bucks County, PA

  18. DLMS Voice Data Entry.

    DTIC Science & Technology

    1980-06-01

    RUN program features a syntactic structure based upon a group of subroutines to perform a group of functions involved in data entry for the DLMS...Code # 120 AGRICULTURAL 430 10 HOSPITAL GABLE 632 121 STOCKYARD 433 151 OBSERVATORY .640 122 WIND I LL 434 152 OBSERVATORY DOME 641 123 CEMETARY BLGS ...associated with each word or group of words. To illustrate the procedure to be followed with the CREATE program, an example is in order. In this example

  19. Contextual analysis of machine-printed addresses

    NASA Astrophysics Data System (ADS)

    Cullen, Peter B.; Ho, Tin K.; Hull, Jonathan J.; Prussak, Michal; Srihari, Sargur N.

    1992-08-01

    The assignment of a nine digit ZIP Code (ZIP + 4 Code) to the digital image of a machine printed address block is a problem of central importance in automated mail sorting. This problem is especially difficult since most addresses do not contain ZIP + 4 Codes and often the information that must be read to match an address to one of the 28 million entries in the ZIP + 4 file is either erroneous, incomplete, or missing altogether. This paper discusses a system for interpreting a machine printed address and assigning a ZIP + 4 Code that uses a constraint satisfaction approach. Words in an address block are first segmented and parsed to assign probable semantic categories. Word images are then recognized by a combination of digit, character, and word recognition algorithms. The control structure uses a constraint satisfaction problem solving approach to match the recognition results to an entry in the ZIP + 4 file. It is shown how this technique can both determine correct responses as well as compensate for incomplete or erroneous information. Experimental results demonstrate the success of this system. In a recent test on over 1000 machine printed address blocks, the ZIP + 4 encode rate was over 73 percent. This compares to the success rate of current postal OCRs which is about 45 percent. Additionally, the word recognition algorithm recognizes over 92 percent of the input images (over 98 percent in the top 10 choices.

  20. A Gestalt approach to Gram-negative entry.

    PubMed

    Silver, Lynn L

    2016-12-15

    A major obstacle confronting the discovery and development of new antibacterial agents to combat resistant Gram-negative (GN) organisms is the lack of a rational process for endowing compounds with properties that allow (or promote) entry into the bacterial cytoplasm. The major permeability difference between GN and Gram-positive (GP) bacteria is the GN outer membrane (OM) which is a permeability barrier itself and potentiates efflux pumps that expel compounds. Based on the fact that OM-permeable and efflux-deleted GNs are sensitive to many anti-GP drugs, recent efforts to approach the GN entry problem have focused on ways of avoiding efflux and transiting or compromising the OM, with the tacit assumption that this could allow entry of compounds into the GN cytoplasm. But bypassing the OM and efflux obstacles does not take into account the additional requirement of penetrating the cytoplasmic membrane (CM) whose sieving properties appear to be orthogonal to that of the OM. That is, tailoring compounds to transit the OM may well compromise their ability to enter the cytoplasm. Thus, a Gestalt approach to understanding the chemical requirements for GN entry seems a useful adjunct. This might consist of characterizing compounds which reach the cytoplasm, grouping (or binning) by routes of entry and formulating chemical 'rules' for those bins. This will require acquisition of data on large numbers of compounds, using non-activity-dependent methods of measuring accumulation in the cytoplasm.

  1. Entry Systems Panel

    NASA Technical Reports Server (NTRS)

    Rasky, Daniel J.; Rummler, Donald R.; Bersch, Charlie; Dixon, Sidney C.

    1993-01-01

    As general findings, lessons learned from shuttle are: (1) bridge established between development center (JSC) Research Centers (ARC, LARC), and industry (RI, LMSC, Corning, Mansville, 3M LTV, Union Carbide, Hexcel) for shuttle TPS; (2) not all test results adequately analyzed or in hindsight, completely encompassing all failure modes; (3) gap heating effects from ground facilities not totally indicative of flight experience; (4) need to design with operations in mind (not just to cost) example: moisture intrusion of GR/EP, many other examples; (5) RSI- developed as point design for maneuvering entry vehicle of high L/D; and (6) RSI - 15 years from invention to use on flight hardware.

  2. Planetary entry experiments

    NASA Technical Reports Server (NTRS)

    Craig, Roger A.

    1994-01-01

    The final report summarizes the results from three research areas: (1) window design for the radiometric measurement of the forebody radiative heating experienced by atmospheric entry spaceraft; (2) survey of the current understanding of chemical species on selected solar system bodies and assess the importance of measurements with regard to vehicle environment and with regard to understanding of planetary atmospheres with emphasis on Venus, Mars, and Titan; and (3) measure and analyze the radiation (VUV to near-IR) from the shock heated gas cap of a blunt body in an Ames arc Jet wind-tunnel facility.

  3. Predictors of student success in entry-level science courses

    NASA Astrophysics Data System (ADS)

    Singh, Mamta K.

    Although the educational evaluation process is useful and valuable and is supported by the Higher Education Act, a strong research base for program evaluation of college entry-level science courses is still lacking. Studies in science disciplines such as, biology, chemistry, and physics have addressed various affective and demographic factors and their relationships to student achievement. However, the literature contains little information that specifically addresses student biology content knowledge skills (basics and higher order thinking skills) and identifies factors that affect students' success in entry-level college science courses. These gate-keeping courses require detailed evaluation if the goal of an institution is to increase students' performance and success in these courses. These factors are, in fact, a stepping stone for increasing the number of graduates in Science, Technology, Engineering, and Mathematics (STEM) majors. The present study measured students' biology content knowledge and investigated students' performance and success in college biology, chemistry, and physics entry-level courses. Seven variables---gender, ethnicity, high school Grade Point Average (GPA), high school science, college major, school financial aid support, and work hours were used as independent variables and course final performance as a dichotomous dependent variable. The sample comprised voluntary student participants in entry-level science courses. The study attempted to explore eight research questions. Content knowledge assessments, demographic information analysis, multiple regression analysis, and binary logistic regression analysis were used to address research questions. The results suggested that high school GPA was a consistently good predictor of students' performance and success in entry-level science courses. Additionally, high school chemistry was a significant predictor variable for student success in entry-level biology and chemistry courses

  4. Entry guidance and entry autopilot (STS-1 baseline)

    NASA Astrophysics Data System (ADS)

    Harpold, J. C.; Hill, O.

    1980-08-01

    Preliminary entry guidance and autopilot software formulations, for use in the Mission Control Center (MCC) entry processor, are presented. The MCC requirements are met by a definition of coordinate systems, a list of parameter definitions for the software formulations, a description of the entry guidance detailed formulation requirements, a description of the detailed autopilot formualtion requirements, a description of the targeting routine, and a set of formulation flow charts.

  5. Entry guidance and entry autopilot (STS-1 baseline)

    NASA Technical Reports Server (NTRS)

    Harpold, J. C.; Hill, O.

    1980-01-01

    Preliminary entry guidance and autopilot software formulations, for use in the Mission Control Center (MCC) entry processor, are presented. The MCC requirements are met by a definition of coordinate systems, a list of parameter definitions for the software formulations, a description of the entry guidance detailed formulation requirements, a description of the detailed autopilot formualtion requirements, a description of the targeting routine, and a set of formulation flow charts.

  6. An Entry Flight Controls Analysis for a Reusable Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Calhoun, Philip

    2000-01-01

    The NASA Langley Research Center has been performing studies to address the feasibility of various single-stage to orbit concepts for use by NASA and the commercial launch industry to provide a lower cost access to space. Some work on the conceptual design of a typical lifting body concept vehicle, designated VentureStar(sup TM) has been conducted in cooperation with the Lockheed Martin Skunk Works. This paper will address the results of a preliminary flight controls assessment of this vehicle concept during the atmospheric entry phase of flight. The work includes control analysis from hypersonic flight at the atmospheric entry through supersonic speeds to final approach and landing at subsonic conditions. The requirements of the flight control effectors are determined over the full range of entry vehicle Mach number conditions. The analysis was performed for a typical maximum crossrange entry trajectory utilizing angle of attack to limit entry heating and providing for energy management, and bank angle to modulation of the lift vector to provide downrange and crossrange capability to fly the vehicle to a specified landing site. Sensitivity of the vehicle open and closed loop characteristics to CG location, control surface mixing strategy and wind gusts are included in the results. An alternative control surface mixing strategy utilizing a reverse aileron technique demonstrated a significant reduction in RCS torque and fuel required to perform bank maneuvers during entry. The results of the control analysis revealed challenges for an early vehicle configuration in the areas of hypersonic pitch trim and subsonic longitudinal controllability.

  7. Advertising and generic market entry.

    PubMed

    Königbauer, Ingrid

    2007-03-01

    The effect of purely persuasive advertising on generic market entry and social welfare is analysed. An incumbent has the possibility to invest in advertising which affects the prescribing physician's perceived relative qualities of the brand-name and the generic version of the drug. Advertising creates product differentiation and can induce generic market entry which is deterred without differentiation due to strong Bertrand competition. However, over-investment in advertising can deter generic market entry under certain conditions and reduces welfare as compared to accommodated market entry.

  8. Membrane fusion during poxvirus entry.

    PubMed

    Moss, Bernard

    2016-12-01

    Poxviruses comprise a large family of enveloped DNA viruses that infect vertebrates and invertebrates. Poxviruses, unlike most DNA viruses, replicate in the cytoplasm and encode enzymes and other proteins that enable entry, gene expression, genome replication, virion assembly and resistance to host defenses. Entry of vaccinia virus, the prototype member of the family, can occur at the plasma membrane or following endocytosis. Whereas many viruses encode one or two proteins for attachment and membrane fusion, vaccinia virus encodes four proteins for attachment and eleven more for membrane fusion and core entry. The entry-fusion proteins are conserved in all poxviruses and form a complex, known as the Entry Fusion Complex (EFC), which is embedded in the membrane of the mature virion. An additional membrane that encloses the mature virion and is discarded prior to entry is present on an extracellular form of the virus. The EFC is held together by multiple interactions that depend on nine of the eleven proteins. The entry process can be divided into attachment, hemifusion and core entry. All eleven EFC proteins are required for core entry and at least eight for hemifusion. To mediate fusion the virus particle is activated by low pH, which removes one or more fusion repressors that interact with EFC components. Additional EFC-interacting fusion repressors insert into cell membranes and prevent secondary infection. The absence of detailed structural information, except for two attachment proteins and one EFC protein, is delaying efforts to determine the fusion mechanism.

  9. The state-of-the-art port of entry workshop

    SciTech Connect

    Godfrey, B.

    1995-05-01

    The increased demand for freight movements through international ports of entry and the signing of the North American Free Trade Agreement (NAFTA) have increased freight traffic at border ports of entry. The State-of-the-Art Port of Entry Workshop initiated a dialogue among technologists and stakeholders to explore the potential uses of technology at border crossings and to set development priorities. International ports of entry are both information and labor intensive, and there are many promising technologies that could be used to provide timely information and optimize inspection resources. Participants universally held that integration of technologies and operations is critical to improving port services. A series of Next Steps was developed to address stakeholder issues and national priorities, such as the National Transportation Policy and National Drug Policy. This report documents the views of the various stakeholders and technologists present at the workshop and outlines future directions of study.

  10. Water Entry of Projectiles

    NASA Astrophysics Data System (ADS)

    Truscott, Tadd T.; Epps, Brenden P.; Belden, Jesse

    2014-01-01

    The free-surface impact of solid objects has been investigated for well over a century. This canonical problem is influenced by many physical parameters, including projectile geometry, material properties, fluid properties, and impact parameters. Through advances in high-speed imaging and visualization techniques, discoveries about the underlying physics have improved our understanding of these phenomena. Improvements to analytical and numerical models have led to critical insights into cavity formation, the depth and time of pinch-off, forces, and trajectories for myriad different impact parameters. This topic spans a wide range of regimes, from low-speed entry phenomena dominated by surface tension to high-speed ballistics, for which cavitation is important. This review surveys experimental, theoretical, and numerical studies over this broad range, utilizing canonical images where possible to enhance intuition and insight into the rich phenomena.

  11. Shuttle entry guidance revisited

    NASA Astrophysics Data System (ADS)

    Mease, Kenneth D.; Kremer, Jean-Paul

    1992-08-01

    The Shuttle entry guidance concept is reviewed which is aimed at tracking a reference drag trajectory that leads to the specified range and velocity for the initiation of the terminal energy management phase. An approximate method of constructing the domain of attraction is proposed, and its validity is ascertained by simulation. An alternative guidance law yielding global exponential tracking in the absence of control saturation is derived using a feedback linearization method. It is noted that the alternative guidance law does not improve on the stability and performance of the current guidance law, for the operating domain and control capability of the Shuttle. It is suggested that the new guidance law with a larger operating domain and increased lift-to-drag capability would be superior.

  12. Shuttle entry guidance revisited

    NASA Technical Reports Server (NTRS)

    Mease, Kenneth D.; Kremer, Jean-Paul

    1992-01-01

    The Shuttle entry guidance concept is reviewed which is aimed at tracking a reference drag trajectory that leads to the specified range and velocity for the initiation of the terminal energy management phase. An approximate method of constructing the domain of attraction is proposed, and its validity is ascertained by simulation. An alternative guidance law yielding global exponential tracking in the absence of control saturation is derived using a feedback linearization method. It is noted that the alternative guidance law does not improve on the stability and performance of the current guidance law, for the operating domain and control capability of the Shuttle. It is suggested that the new guidance law with a larger operating domain and increased lift-to-drag capability would be superior.

  13. Image compression using address-vector quantization

    NASA Astrophysics Data System (ADS)

    Nasrabadi, Nasser M.; Feng, Yushu

    1990-12-01

    A novel vector quantization scheme, the address-vector quantizer (A-VQ), is proposed which exploits the interblock correlation by encoding a group of blocks together using an address-codebook (AC). The AC is a set of address-codevectors (ACVs), each representing a combination of addresses or indices. Each element of the ACV is an address of an entry in the LBG-codebook, representing a vector-quantized block. The AC consists of an active (addressable) region and an inactive (nonaddressable) region. During encoding the ACVs in the AC are reordered adaptively to bring the most probable ACVs into the active region. When encoding an ACV, the active region is checked, and if such an address combination exists, its index is transmitted to the receiver. Otherwise, the address of each block is transmitted individually. The SNR of the images encoded by the A-VQ method is the same as that of a memoryless vector quantizer, but the bit rate is by a factor of approximately two.

  14. Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry.

    PubMed

    Lin, Han-Xin; Feng, Yan; Tu, Xinming; Zhao, Xuesen; Hsieh, Chih-Heng; Griffin, Lauren; Junop, Murray; Zhang, Chengsheng

    2011-09-01

    The spike (S) protein of human coronavirus NL63 (HCoV-NL63) mediates both cell attachment by binding to its receptor hACE2 and membrane fusion during virus entry. We have previously identified the receptor-binding domain (RBD) and residues important for RBD-hACE2 association. Here, we further characterized the S protein by investigating the roles of the cytoplasmic tail and 19 residues located in the RBD in protein accumulation, receptor binding, and pseudotype virus entry. For these purposes, we first identified an entry-efficient S gene template from a pool of gene variants and used it as a backbone to generate a series of cytoplasmic tail deletion and single residue substitution mutants. Our results showed that: (i) deletion of 18aa from the C-terminus enhanced the S protein accumulation and virus entry, which might be due to the deletion of intracellular retention signals; (ii) further deletion to residue 29 also enhanced the amount of S protein on the cell surface and in virion, but reduced virus entry by 25%, suggesting that residues 19-29 contributes to membrane fusion; (iii) a 29aa-deletion mutant had a defect in anchoring on the plasma membrane, which led to a dramatic decrease of S protein in virion and virus entry; (iv) a total of 15 residues (Y498, V499, V531, G534, G537, D538, S540, G575, S576, E582, W585, Y590, T591, V593 and G594) within RBD were important for receptor binding and virus entry. They probably form three receptor binding motifs, and the third motif is conserved between NL63 and SARS-CoV.

  15. Parachute Swivel Mechanism for planetary entry

    NASA Technical Reports Server (NTRS)

    Birner, R.; Kaese, J.; Koller, F.; Muehlner, E.; Luhmann, H.-J.

    1993-01-01

    A parachute swivel mechanism (PSM) for planetary entry missions such as a Mars probe (MARSNET) or return of cometary material samples (ROSETTA mission) has been developed. The purpose of the PSM is to decouple the spin of the probe from the parachute, with low friction torque, during both the deployment and descent phases. Critical requirements are high shock loads, low friction, low temperatures, and several years of storage in the deep space environment (during the cruise phase of the probe, prior to operation). The design uses a main thrust ball bearing to cope with the load requirement and a smaller thrust ball bearing for guiding of the shaft. Except for use on the Viking and Galileo swivels, it appears that this type of bearing has very rarely been employed in space mechanisms, so that little is known of its friction behavior with dry lubrication. A slip ring assembly allows the transfer of electrical power for post-reefing of the parachute. A test program has been conducted covering the environmental conditions of Mars entry and Earth reentry. This paper describes requirement constraints, model missions of planetary entries, a bearing trade-off, analyses performed, design details, the lubrication system, and test results (friction torque versus load/spin rate). In addition, the design of the test rig is addressed.

  16. 19 CFR 10.31 - Entry; bond.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... not over $250, the form prescribed for the informal entry of importations by mail, in baggage, or by... consumption entry summary, each temporary importation bond entry summary shall include: (i) The HTSUS... consumption entry on the date of the original arrival. (d) (e) The entry or invoice shall: (1) Describe...

  17. Montana Rivers Information System : Edit/Entry Program User's Manual.

    SciTech Connect

    United States. Bonneville Power Administration; Montana Department of Fish, Wildlife and Parks

    1992-07-01

    The Montana Rivers Information System (MRIS) was initiated to assess the state`s fish, wildlife, and recreation value; and natural cultural, and geologic features. The MRIS is now a set of data bases containing part of the information in the Natural Heritage Program natural features and threatened and endangered species data bases and comprises of the Montana Interagency Stream Fisheries Database; the MDFWP Recreation Database; and the MDFWP Wildlife Geographic Information System. The purpose of this User`s Manual is to describe to the user how to maintain the MRIS database of their choice by updating, changing, deleting, and adding records using the edit/entry programs; and to provide to the user all information and instructions necessary to complete data entry into the MRIS databases.

  18. 77 FR 2560 - Agency Information Collection Activities: Entry Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... Affairs, Office of Management and Budget. Comments should be addressed to the OMB Desk Officer for Customs... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Entry Summary AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: 30-Day notice...

  19. Integrated alarm annunciation and entry control systems -- Survey results

    SciTech Connect

    Clever, J.J.; Arakaki, L.H.; Monaco, F.M.; Juarros, L.E.; Quintana, G.R.

    1993-10-01

    This report provides the results and analyses of a detailed survey undertaken in Summer 1993 to address integrated intrusion detection alarm annunciation and entry control system issues. This survey was undertaken as a first attempt toward beginning to answer questions about integrated systems and commercial capabilities to meet or partially meet US Department of Energy (DOE) site needs.

  20. Predictors of Student Success in Entry-Level Science Courses

    ERIC Educational Resources Information Center

    Singh, Mamta K.

    2009-01-01

    Although the educational evaluation process is useful and valuable and is supported by the Higher Education Act, a strong research base for program evaluation of college entry-level science courses is still lacking. Studies in science disciplines such as, biology, chemistry, and physics have addressed various affective and demographic factors and…

  1. Multiple Deep Jovian Atmospheric Entry Probes: Building on the Galileo Probe

    NASA Technical Reports Server (NTRS)

    Spilker, T.; Hubbard, W.

    1998-01-01

    Following on the very successful Galileo Entry Probe mission, studies underway at the Jet Propulsion Laboratory (JPL) address the feasibility and cost of the Jupiter Deep Multi-probes (JDMP) mission to deliver and support multiple deep (100 bar level or deeper) atmospheric entry probes to Jupiter.

  2. 19 CFR 142.17 - One entry summary for multiple entries.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false One entry summary for multiple entries. 142.17...; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Entry Summary Documentation § 142.17 One entry summary for multiple entries. (a) Requirements. Except as provided in paragraph (b) of this section, the...

  3. 19 CFR 142.17 - One entry summary for multiple entries.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false One entry summary for multiple entries. 142.17...; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Entry Summary Documentation § 142.17 One entry summary for multiple entries. (a) Requirements. Except as provided in paragraph (b) of this section, the...

  4. 19 CFR 142.17 - One entry summary for multiple entries.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false One entry summary for multiple entries. 142.17...; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Entry Summary Documentation § 142.17 One entry summary for multiple entries. (a) Requirements. Except as provided in paragraph (b) of this section, the...

  5. 19 CFR 142.17 - One entry summary for multiple entries.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false One entry summary for multiple entries. 142.17...; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Entry Summary Documentation § 142.17 One entry summary for multiple entries. (a) Requirements. Except as provided in paragraph (b) of this section, the...

  6. Heatshield for Extreme Entry Environment Technology (HEEET)

    NASA Technical Reports Server (NTRS)

    Venkatapathy, E.; Ellerby, D.; Stackpoole, M..; Peterson, K.; Gage, P.; Beerman, A.; Blosser, M.; Chinnapongse, R.; Dillman, R.; Feldman, J.; Gasch, M.; Munk, M.; Prabhu, D.; Poteet, C.

    2013-01-01

    Heat-shield for Extreme Entry Technology (HEEET) project is based on the 3-D Woven TPS, an emerging innovative and game changing technology funded by SMD and STMD to fill the ablative TPS gap that exists currently for reaching the depths of Saturn and Venus. Woven TPS technology will address the challenges currently faced by the Venus, Saturn, and higher speed sample return mission Science community due to lack of availability of the only TPS, namely Carbon Phenolic and enable the Science community to move forward with proposals in this decade with Woven TPS. This presentation describes the approach in maturing the technology in the next three years enabling NF-4 mission proposers to address the challenges of Venus, Saturn or higher speed sample return missions.

  7. ESA Venus Entry Probe Study

    NASA Technical Reports Server (NTRS)

    vandenBerg, M. L.; Falkner, P.; Phipps, A.; Underwood, J. C.; Lingard, J. S.; Moorhouse, J.; Kraft, S.; Peacock, A.

    2005-01-01

    The Venus Entry Probe is one of ESA s Technology Reference Studies (TRS). The purpose of the Technology Reference Studies is to provide a focus for the development of strategically important technologies that are of likely relevance for future scientific missions. The aim of the Venus Entry Probe TRS is to study approaches for low cost in-situ exploration of Venus and other planetary bodies with a significant atmosphere. In this paper, the mission objectives and an outline of the mission concept of the Venus Entry Probe TRS are presented.

  8. 27. View of entry door to vestibule to MWOC entry ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. View of entry door to vestibule to MWOC entry door in transmitter building no. 102 (note coded key pad to left and intercom phone on left) and door to the central systems monitor room (CSMR) to right (out of sight). - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  9. Adaptable Deployable Entry and Placement Technology (ADEPT)

    NASA Video Gallery

    The Adaptable, Deployable Entry Placement Technology (ADEPT) Project will test and demonstrate a deployable aeroshell concept as a viable thermal protection system for entry, descent, and landing o...

  10. Addressing Ozone Layer Depletion

    EPA Pesticide Factsheets

    Access information on EPA's efforts to address ozone layer depletion through regulations, collaborations with stakeholders, international treaties, partnerships with the private sector, and enforcement actions under Title VI of the Clean Air Act.

  11. Deletion 14q and pericentric inversion 14.

    PubMed Central

    Nielsen, J; Homma, A; Rasmussen, K; Ried, E; Sorensen, K; Saldana-Garcia, P

    1978-01-01

    A woman with deletion 14q as well as inversion 14 is presented, and physical signs are compared with those of patients with deletion long arm 13. No previous case of deletion long arm 14 has been published. Images PMID:671492

  12. Entry, Descent, Landing Animation (Animation)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Click on the image for Entry, Descent, Landing animation

    This animation illustrates the path the Stardust return capsule will follow once it enters Earth's atmosphere.

  13. Atmospheric maneuvering during Martian entry

    NASA Astrophysics Data System (ADS)

    Tauber, Michael E.; Bowles, Jeffrey V.; Yang, Lily

    A comparative-advantages study is made of two different Martian atmospheric entry maneuvers, on the basis of calculation results for the case of a vehicle with a maximum L/D ratio of 2.3. Entries from a highly elliptical Martian orbit at 5 km/sec are more difficult than those from a lower altitude and speed orbit at 3.5 km/sec, due to their more stringent guidance requirements. Efforts to reduce the deceleration for the higher speed entry by lift-modulation achieved a 40-percent reduction, but at the cost of a 50-percent decrease in lateral range. The lower-speed entry's gliding trajectory is noted to encounter a far more benign atmospheric environment.

  14. Re-entry Experiment Launch

    NASA Video Gallery

    On August 10, 2009, NASA successfully launched the Inflatable Re-entry Vehicle Experiment (IRVE) and proved that spacecraft can use inflatable heat shields to reduce speed and provide protection du...

  15. Atmospheric Entry of Carbonate Micrometeoroids

    NASA Astrophysics Data System (ADS)

    Micca Longo, G.; Longo, S.

    2017-02-01

    Micrometeoroids have similarities in chemistry and mineralogy to the CI, CM, and CR chondrites. A first study of carbonate micrometeoroids atmospheric entry is performed. A thermal decomposition model of initially pure magnesium carbonate is proposed.

  16. The Montana Rivers Information System: Edit/entry program user`s manual

    SciTech Connect

    Not Available

    1992-07-01

    The Montana Rivers Information System (MRIS) was initiated to assess the state`s fish, wildlife, and recreation value; and natural cultural and geologic features. The MRIS is now a set of data bases containing part of the information in the Natural Heritage Program natural features and threatened and endangered species data bases. The purpose of this User`s Manual is to: (1) describe to the user how to maintain the MRIS database of their choice by updating, changing, deleting, and adding records using the edit/entry programs; and (2) provide to the user all information and instructions necessary to complete data entry into the MRIS databases.

  17. 19 CFR 191.143 - Drawback entry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed...

  18. 19 CFR 191.143 - Drawback entry.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed...

  19. 19 CFR 191.143 - Drawback entry.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed...

  20. 19 CFR 191.143 - Drawback entry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed...

  1. 19 CFR 191.143 - Drawback entry.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed...

  2. Lunar Entry Downmode Options for Orion

    NASA Technical Reports Server (NTRS)

    Smith, Kelly; Rea, Jeremy

    2016-01-01

    Traditional ballistic entry does not scale well to higher energy entry trajectories. Clutch algorithm is a two-stage approach with the capture stage and load relief stage. Clutch may offer expansion of the operational entry corridor. Clutch is a candidate solution for Exploration Mission-2's degraded entry mode.

  3. 19 CFR 142.16 - Entry summary documentation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry summary documentation. 142.16 Section 142.16... TREASURY (CONTINUED) ENTRY PROCESS Entry Summary Documentation § 142.16 Entry summary documentation. (a) Entry summary not filed at time of entry. When the entry documentation is filed before the entry...

  4. Herpes Simplex Virus Type 2 Glycoprotein H Interacts with Integrin αvβ3 To Facilitate Viral Entry and Calcium Signaling in Human Genital Tract Epithelial Cells

    PubMed Central

    Cheshenko, Natalia; Trepanier, Janie B.; González, Pablo A.; Eugenin, Eliseo A.; Jacobs, William R.

    2014-01-01

    ABSTRACT Herpes simplex virus (HSV) entry requires multiple interactions at the cell surface and activation of a complex calcium signaling cascade. Previous studies demonstrated that integrins participate in this process, but their precise role has not been determined. These studies were designed to test the hypothesis that integrin αvβ3 signaling promotes the release of intracellular calcium (Ca2+) stores and contributes to viral entry and cell-to-cell spread. Transfection of cells with small interfering RNA (siRNA) targeting integrin αvβ3, but not other integrin subunits, or treatment with cilengitide, an Arg-Gly-Asp (RGD) mimetic, impaired HSV-induced Ca2+ release, viral entry, plaque formation, and cell-to-cell spread of HSV-1 and HSV-2 in human cervical and primary genital tract epithelial cells. Coimmunoprecipitation studies and proximity ligation assays indicated that integrin αvβ3 interacts with glycoprotein H (gH). An HSV-2 gH-null virus was engineered to further assess the role of gH in the virus-induced signaling cascade. The gH-2-null virus bound to cells and activated Akt to induce a small Ca2+ response at the plasma membrane, but it failed to trigger the release of cytoplasmic Ca2+ stores and was impaired for entry and cell-to-cell spread. Silencing of integrin αvβ3 and deletion of gH prevented phosphorylation of focal adhesion kinase (FAK) and the transport of viral capsids to the nuclear pore. Together, these findings demonstrate that integrin signaling is activated downstream of virus-induced Akt signaling and facilitates viral entry through interactions with gH by activating the release of intracellular Ca2+ and FAK phosphorylation. These findings suggest a new target for HSV treatment and suppression. IMPORTANCE Herpes simplex viruses are the leading cause of genital disease worldwide, the most common infection associated with neonatal encephalitis, and a major cofactor for HIV acquisition and transmission. There is no effective vaccine

  5. Addressing Social Issues.

    ERIC Educational Resources Information Center

    Schoebel, Susan

    1991-01-01

    Maintains that advertising can help people become more aware of social responsibilities. Describes a successful nationwide newspaper advertising competition for college students in which ads address social issues such as literacy, drugs, teen suicide, and teen pregnancy. Notes how the ads have helped grassroots programs throughout the United…

  6. Invitational Addresses, 1965.

    ERIC Educational Resources Information Center

    Gates, Arthur I.; And Others

    The full texts of invitational addresses given at the 1965 International Reading Association (IRA) Convention in Detroit, Michigan, by six recipients of IRA citation awards are presented. Gates suggests steps IRA should take to revive and redirect reading research. McCallister discusses the implications of the changing and expanding vocabulary of…

  7. States Address Achievement Gaps.

    ERIC Educational Resources Information Center

    Christie, Kathy

    2002-01-01

    Summarizes 2 state initiatives to address the achievement gap: North Carolina's report by the Advisory Commission on Raising Achievement and Closing Gaps, containing an 11-point strategy, and Kentucky's legislation putting in place 10 specific processes. The North Carolina report is available at www.dpi.state.nc.us.closingthegap; Kentucky's…

  8. Addressing Sexual Harassment

    ERIC Educational Resources Information Center

    Young, Ellie L.; Ashbaker, Betty Y.

    2008-01-01

    This article discusses ways on how to address the problem of sexual harassment in schools. Sexual harassment--simply defined as any unwanted and unwelcome sexual behavior--is a sensitive topic. Merely providing students, parents, and staff members with information about the school's sexual harassment policy is insufficient; schools must take…

  9. Inflatable Re-entry Vehicle Experiment (IRVE-4) Overview

    NASA Technical Reports Server (NTRS)

    Litton, Daniel K.; Bose, David M.; Cheatwood, F. McNeil; Hughes, Stephen; Wright, Henry S.; Lindell, Michael C.; Derry, Stephen D.; Olds, Aaron

    2011-01-01

    The suite of Inflatable Re-Entry Vehicle Experiments (IRVE) is designed to further our knowledge and understanding of Hypersonic Inflatable Aerodynamic Decelerators (HIADs). Before infusion into a future mission, three challenges need to be addressed: surviving the heat pulse during re-entry, demonstrating system performance at relevant scales, and demonstrating controllability in the atmosphere. IRVE-4 will contribute to a better understanding of controllability by characterizing how a HIAD responds to a set of controlled inputs. The ability to control a HIAD is vital for missions that are g-limited, require precision targeting and guidance for aerocapture or entry, descent, and landing. The IRVE-4 flight test will focus on taking a first look into controlling a HIAD. This paper will give an overview of the IRVE-4 mission including the control response portion of the flight test sequence, and will provide a review of the mission s development.

  10. Mars Science Laboratory Entry Guidance

    NASA Technical Reports Server (NTRS)

    Mendeck, Gavin F.

    2011-01-01

    The Mars Science Laboratory will be the first Mars mission to attempt a guided entry with the objective of safely delivering the entry vehicle to a survivable parachute deploy state within 12.5 km of the pre-designated parachute deploy coordinates. The Entry Terminal Point Controller guidance algorithm is derived from the final phase Apollo Command Module guidance and, like Apollo, modulates the bank angle to control range based on deviations in range, altitude rate, and drag acceleration from a reference trajectory. For application to Mars landers which must make use of the tenuous Martian atmosphere, it is critical to balance the lift of the vehicle to minimize the range while still ensuring a safe deploy altitude. An overview of the process to generate optimized guidance settings is presented, discussing improvements made over the last nine years. Performance tradeoffs between ellipse size and deploy altitude will be presented, along with imposed constraints of entry acceleration and heating. Performance sensitivities to the bank reversal deadbands, heading alignment, attitude initialization error, and entry delivery errors are presented.

  11. 19 CFR 143.36 - Form of immediate delivery, entry and entry summary.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Form of immediate delivery, entry and entry summary. 143.36 Section 143.36 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing § 143.36 Form of immediate delivery, entry and...

  12. The second extracellular loop dictates Occludin-mediated HCV entry.

    PubMed

    Liu, Shufeng; Kuo, Wayne; Yang, Wei; Liu, Weiqun; Gibson, Gregory A; Dorko, Kenneth; Watkins, Simon C; Strom, Stephen C; Wang, Tianyi

    2010-11-10

    Recent findings have implicated tight junction (TJ) protein Occludin (OCLN) as an essential factor for hepatitis C virus (HCV) to enter human hepatocytes. To gain insights into OCLN-mediated HCV entry, we created a panel of OCLN deletion mutants and found that without impairing OCLN's cell surface localization, removal of the extracellular loop 2 (EL2) from OCLN abolished both its ability to mediate HIV-HCV pseudotypes' (HCVpp) entry as well as its ability to coprecipitate HCV glycoprotein E2. Recombinant OCLN EL2, however, failed to robustly bind soluble E2 (sE2) in pull-down assays. Subsequent studies revealed that OCLN formed complex with Dynamin II, an important GTPase for endocytosis, in an EL2-dependent fashion. HCVpp, as well as cell culture grown HCV (HCVcc), was sensitive to Dynamin knockdown or inhibition. We conclude that OCLN EL2 dictates the Dynamin-dependent HCV entry. Furthermore, OCLN could function to bridge virions to Dynamin-dependent endocytic machineries.

  13. The water entry of water

    NASA Astrophysics Data System (ADS)

    Speirs, Nathan; Pan, Zhao; Belden, Jesse; Truscott, Tadd

    2016-11-01

    Though water entry has been studied for over a century, there has been a disconnect between solid object water entry and research on liquid impacting on a liquid pool. In addition, few have studied multiple objects impacting a liquid bath sequentially. We show that the impact of multi-droplet streams and liquid jets on a liquid pool display similar behavior to solid body water entry. In particular, the cavities of both droplet streams and jets exhibit three types of cavity seal previously found for hydrophobic spheres at low Bond numbers. Additionally, low-frequency droplet streams create three novel cavity seal types, which can be predicted with a new non-dimensional frequency. The cavity depth for both droplet and jet impact is rationalized by an energy scaling analysis. Finally, we examine the similarities and differences in cavity dynamics for multi-droplet streams and continuous liquid jets.

  14. Content Addressable Memory Project

    DTIC Science & Technology

    1990-11-01

    The Content Addressable M1-emory Project consists of the development of several experimental software systems on an AMT Distributed Array Processor...searching (database) compiler algorithms memory management other systems software) Linear C is an unlovely hybrid language which imports the CAM...memory from AMT’s operating system for the DAP; how- ever, other than this limitation, the memory management routines work exactly as their C counterparts

  15. MSL EDL Entry Guidance using the Entry Terminal Point Controller

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The Mars Science Laboratory will be the first Mars mission to attempt a guided entry with the objective of safely delivering the entry vehicle to a survivable parachute deploy state within 10 km of the pre-designated landing site. The Entry Terminal Point Controller guidance algorithm is derived from the final phase Apollo Command Module guidance and, like Apollo, modulates the bank angle to control range based on deviations in range, altitude rate, and drag acceleration from a reference trajectory. For application to Mars landers which must make use of the tenuous Martian atmosphere, it is critical to balance the lift of the vehicle to minimize the range while still ensuring a safe deploy altitude. An overview of the process to generate optimized guidance settings is presented, discussing improvements made over the last four years. Performance tradeoffs between ellipse size and deploy altitude will be presented, along with imposed constraints of entry acceleration and heating. Performance sensitivities to the bank reversal deadbands, heading alignment, attitude initialization error, and atmospheric delivery errors are presented. Guidance settings for contingency operations, such as those appropriate for severe dust storm scenarios, are evaluated.

  16. Contributions of herpes simplex virus type 1 envelope proteins to entry by endocytosis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Herpes simplex virus (HSV) proteins specifically required for endocytic entry but not direct penetration have not been identified. HSVs deleted of gE, gG, gI, gJ, gM, UL45, or Us9 entered cells via either pH-dependent or pH-independent endocytosis and were inactivated by mildly acidic pH. Thus, the ...

  17. 19 CFR 141.64 - Review and correction of entry and entry summary documentation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY OF MERCHANDISE Presentation of Entry Papers § 141.64... be reviewed before acceptance to ensure that all entry and statistical requirements are complied...

  18. Bioreactors Addressing Diabetes Mellitus

    PubMed Central

    Minteer, Danielle M.; Gerlach, Jorg C.

    2014-01-01

    The concept of bioreactors in biochemical engineering is a well-established process; however, the idea of applying bioreactor technology to biomedical and tissue engineering issues is relatively novel and has been rapidly accepted as a culture model. Tissue engineers have developed and adapted various types of bioreactors in which to culture many different cell types and therapies addressing several diseases, including diabetes mellitus types 1 and 2. With a rising world of bioreactor development and an ever increasing diagnosis rate of diabetes, this review aims to highlight bioreactor history and emerging bioreactor technologies used for diabetes-related cell culture and therapies. PMID:25160666

  19. Bioreactors addressing diabetes mellitus.

    PubMed

    Minteer, Danielle M; Gerlach, Jorg C; Marra, Kacey G

    2014-11-01

    The concept of bioreactors in biochemical engineering is a well-established process; however, the idea of applying bioreactor technology to biomedical and tissue engineering issues is relatively novel and has been rapidly accepted as a culture model. Tissue engineers have developed and adapted various types of bioreactors in which to culture many different cell types and therapies addressing several diseases, including diabetes mellitus types 1 and 2. With a rising world of bioreactor development and an ever increasing diagnosis rate of diabetes, this review aims to highlight bioreactor history and emerging bioreactor technologies used for diabetes-related cell culture and therapies.

  20. Content addressable memory project

    NASA Technical Reports Server (NTRS)

    Hall, J. Storrs; Levy, Saul; Smith, Donald E.; Miyake, Keith M.

    1992-01-01

    A parameterized version of the tree processor was designed and tested (by simulation). The leaf processor design is 90 percent complete. We expect to complete and test a combination of tree and leaf cell designs in the next period. Work is proceeding on algorithms for the computer aided manufacturing (CAM), and once the design is complete we will begin simulating algorithms for large problems. The following topics are covered: (1) the practical implementation of content addressable memory; (2) design of a LEAF cell for the Rutgers CAM architecture; (3) a circuit design tool user's manual; and (4) design and analysis of efficient hierarchical interconnection networks.

  1. Numerical Skip-Entry Guidance

    NASA Technical Reports Server (NTRS)

    Tigges, Michael; Crull, Timothy; Rea, Jeremy; Johnson, Wyatt

    2006-01-01

    This paper assesses a preliminary guidance and targeting strategy for accomplishing Skip-Entry (SE) flight during a lunar return-capsule entry flight. One of the primary benefits of flying a SE trajectory is to provide the crew with continuous Continental United States (CONUS) landing site access throughout the lunar month. Without a SE capability, the capsule must land either in water or at one of several distributed land sites in the Southern Hemisphere for a significant portion of a lunar month using a landing and recovery scenario similar to that employed during the Apollo program. With a SE trajectory, the capsule can land either in water at a site in proximity to CONUS or at one of several distributed landing sites within CONUS, thereby simplifying the operational requirements for crew retrieval and vehicle recovery, and possibly enabling a high degree of vehicle reusability. Note that a SE capability does not require that the vehicle land on land. A SE capability enables a longer-range flight than a direct-entry flight, which permits the vehicle to land at a much greater distance from the Entry Interface (EI) point. This does not exclude using this approach to push the landing point to a water location in proximity of CONUS and utilizing water or airborne recovery forces.

  2. Planetary Landers and Entry Probes

    NASA Astrophysics Data System (ADS)

    Ball, Andrew J.; Garry, James R. C.; Lorenz, Ralph D.; Kerzhanovich, Viktor V.

    2007-05-01

    Preface; Acknowledgements; Part I. Engineering Issues Specific to Entry Probes, Landers or Penetrators: 1. Mission goals and system engineering; 2. Accommodation, launch, cruise and arrival from orbit or interplanetary trajectory; 3. Entering atmospheres; 4. Descent through an atmosphere; 5. Descent to an airless body; 6. Planetary balloons, aircraft, submarines and cryobots; 7. Arrival at a surface; 8. Thermal control of landers and entry probes; 9. Power systems; 10. Communication and tracking of entry probes; 11. Radiation environment; 12. Surface activities: arms, drills, moles and mobility; 13. Structures; 14. Contamination of spacecraft and planets; Part II. Previous Atmosphere/Surface Vehicles and Their Payloads: 15. Destructive impact probes; 16. Atmospheric entry probes; 17. Pod landers; 18. Legged landers; 19. Payload delivery penetrators; 20. Small body surface missions; Part III. 'Case Studies': 21. Surveyor landers; 22. Galileo probe; 23. Huygens; 24. Mars Pathfinder and Sojourner; 25. Deep Space 2 Mars microprobes; 26. Rosetta lander Philae; 27. Mars exploration rovers: Spirit and Opportunity; Appendix: Some key parameters for bodies in the Solar System; List of acronyms; Bibliography; References; Index.

  3. Planetary Landers and Entry Probes

    NASA Astrophysics Data System (ADS)

    Ball, Andrew; Garry, James; Lorenz, Ralph; Kerzhanovich, Viktor

    2010-02-01

    Preface; Acknowledgements; Part I. Engineering Issues Specific to Entry Probes, Landers or Penetrators: 1. Mission goals and system engineering; 2. Accommodation, launch, cruise and arrival from orbit or interplanetary trajectory; 3. Entering atmospheres; 4. Descent through an atmosphere; 5. Descent to an airless body; 6. Planetary balloons, aircraft, submarines and cryobots; 7. Arrival at a surface; 8. Thermal control of landers and entry probes; 9. Power systems; 10. Communication and tracking of entry probes; 11. Radiation environment; 12. Surface activities: arms, drills, moles and mobility; 13. Structures; 14. Contamination of spacecraft and planets; Part II. Previous Atmosphere/Surface Vehicles and Their Payloads: 15. Destructive impact probes; 16. Atmospheric entry probes; 17. Pod landers; 18. Legged landers; 19. Payload delivery penetrators; 20. Small body surface missions; Part III. 'Case Studies': 21. Surveyor landers; 22. Galileo probe; 23. Huygens; 24. Mars Pathfinder and Sojourner; 25. Deep Space 2 Mars microprobes; 26. Rosetta lander Philae; 27. Mars exploration rovers: Spirit and Opportunity; Appendix: Some key parameters for bodies in the Solar System; List of acronyms; Bibliography; References; Index.

  4. Addressing Environmental Health Inequalities

    PubMed Central

    Gouveia, Nelson

    2016-01-01

    Environmental health inequalities refer to health hazards disproportionately or unfairly distributed among the most vulnerable social groups, which are generally the most discriminated, poor populations and minorities affected by environmental risks. Although it has been known for a long time that health and disease are socially determined, only recently has this idea been incorporated into the conceptual and practical framework for the formulation of policies and strategies regarding health. In this Special Issue of the International Journal of Environmental Research and Public Health (IJERPH), “Addressing Environmental Health Inequalities—Proceedings from the ISEE Conference 2015”, we incorporate nine papers that were presented at the 27th Conference of the International Society for Environmental Epidemiology (ISEE), held in Sao Paulo, Brazil, in 2015. This small collection of articles provides a brief overview of the different aspects of this topic. Addressing environmental health inequalities is important for the transformation of our reality and for changing the actual development model towards more just, democratic, and sustainable societies driven by another form of relationship between nature, economy, science, and politics. PMID:27618906

  5. 19 CFR 141.91 - Entry without required invoice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... summary (or the entry, if there is no entry summary) documentation, unless the invoice is needed for... the date of the entry summary (or the entry, if there is no entry summary) is required to be filed... required invoice is not available in proper form at the time the entry or entry summary documentation...

  6. Content addressable memory project

    NASA Technical Reports Server (NTRS)

    Hall, Josh; Levy, Saul; Smith, D.; Wei, S.; Miyake, K.; Murdocca, M.

    1991-01-01

    The progress on the Rutgers CAM (Content Addressable Memory) Project is described. The overall design of the system is completed at the architectural level and described. The machine is composed of two kinds of cells: (1) the CAM cells which include both memory and processor, and support local processing within each cell; and (2) the tree cells, which have smaller instruction set, and provide global processing over the CAM cells. A parameterized design of the basic CAM cell is completed. Progress was made on the final specification of the CPS. The machine architecture was driven by the design of algorithms whose requirements are reflected in the resulted instruction set(s). A few of these algorithms are described.

  7. 19 CFR 149.6 - Entry and entry summary documentation and Importer Security Filing submitted via a single...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry and entry summary documentation and Importer...) IMPORTER SECURITY FILING § 149.6 Entry and entry summary documentation and Importer Security Filing... of this part via the same electronic transmission as entry or entry/entry summary...

  8. 19 CFR 149.6 - Entry and entry summary documentation and Importer Security Filing submitted via a single...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Entry and entry summary documentation and Importer...) IMPORTER SECURITY FILING § 149.6 Entry and entry summary documentation and Importer Security Filing... of this part via the same electronic transmission as entry or entry/entry summary...

  9. 19 CFR 149.6 - Entry and entry summary documentation and Importer Security Filing submitted via a single...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Entry and entry summary documentation and Importer...) IMPORTER SECURITY FILING § 149.6 Entry and entry summary documentation and Importer Security Filing... of this part via the same electronic transmission as entry or entry/entry summary...

  10. 19 CFR 149.6 - Entry and entry summary documentation and Importer Security Filing submitted via a single...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Entry and entry summary documentation and Importer...) IMPORTER SECURITY FILING § 149.6 Entry and entry summary documentation and Importer Security Filing... of this part via the same electronic transmission as entry or entry/entry summary...

  11. 19 CFR 149.6 - Entry and entry summary documentation and Importer Security Filing submitted via a single...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Entry and entry summary documentation and Importer...) IMPORTER SECURITY FILING § 149.6 Entry and entry summary documentation and Importer Security Filing... of this part via the same electronic transmission as entry or entry/entry summary...

  12. 32 CFR 770.28 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Installations in the... State of Hawaii, entry into a naval installation is not permitted without the permission of...

  13. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  14. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  15. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  16. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  17. 32 CFR 770.50 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.50 Entry restrictions. Except for military personnel and civilian employees...

  18. Passenger Deletions Generate Therapeutic Vulnerabilities in Cancer

    PubMed Central

    Muller, Florian L.; Colla, Simona; Aquilanti, Elisa; Manzo, Veronica; Genovese, Giannicola; Lee, Jaclyn; Eisenson, Dan; Narurkar, Rujuta; Deng, Pingna; Nezi, Luigi; Lee, Michelle; Hu, Baoli; Hu, Jian; Sahin, Ergun; Ong, Derrick; Fletcher-Sananikone, Eliot; Ho, Dennis; Kwong, Lawrence; Brennan, Cameron; Wang, Y. Alan; Chin, Lynda; DePinho, Ronald A.

    2013-01-01

    Inactivation of tumor suppressor genes via homozygous deletion is a prototypic event in the cancer genome, yet such deletions often encompass neighboring genes. We hypothesized that homozygous deletions in such passenger genes can expose cancer-specific therapeutic vulnerabilities in the case where the collaterally deleted gene is a member of a functionally redundant family of genes exercising an essential function. The glycolytic gene Enolase 1 (ENO1) in the 1p36 locus is deleted in Glioblastoma (GBM), which is tolerated by expression of ENO2. We demonstrate that shRNA-mediated extinction of ENO2 selectively inhibits growth, survival, and tumorigenic potential of ENO1-deleted GBM cells and that the enolase inhibitor phosphonoacetohydroxamate (PhAH) is selectively toxic to ENO1-deleted GBM cells relative to ENO1-intact GBM cells or normal astrocytes. The principle of collateral vulnerability should be applicable to other passenger deleted genes encoding functionally-redundant essential activities and provide an effective treatment strategy for cancers harboring such genomic events. PMID:22895339

  19. Using Competencies to Assess Entry-Level Knowledge of Students Graduating from Parks and Recreation Academic Programs

    ERIC Educational Resources Information Center

    Hurd, Amy R.; Elkins, Daniel J.; Beggs, Brent A.

    2014-01-01

    To address the Council on Accreditation of Parks, Recreation, Tourism, and Related Professions accreditation standard 7.01.01, the Entry Level Competency Assessment was developed to measure 46 competencies in four categories needed by entry level professionals. Students rated their competence prior to beginning their senior internship. The results…

  20. The role of digital data entry in participatory environmental monitoring.

    PubMed

    Brammer, Jeremy R; Brunet, Nicolas D; Burton, A Cole; Cuerrier, Alain; Danielsen, Finn; Dewan, Kanwaljeet; Herrmann, Thora Martina; Jackson, Micha V; Kennett, Rod; Larocque, Guillaume; Mulrennan, Monica; Pratihast, Arun Kumar; Saint-Arnaud, Marie; Scott, Colin; Humphries, Murray M

    2016-12-01

    Many argue that monitoring conducted exclusively by scientists is insufficient to address ongoing environmental challenges. One solution entails the use of mobile digital devices in participatory monitoring (PM) programs. But how digital data entry affects programs with varying levels of stakeholder participation, from nonscientists collecting field data to nonscientists administering every step of a monitoring program, remains unclear. We reviewed the successes, in terms of management interventions and sustainability, of 107 monitoring programs described in the literature (hereafter programs) and compared these with case studies from our PM experiences in Australia, Canada, Ethiopia, Ghana, Greenland, and Vietnam (hereafter cases). Our literature review showed that participatory programs were less likely to use digital devices, and 2 of our 3 more participatory cases were also slow to adopt digital data entry. Programs that were participatory and used digital devices were more likely to report management actions, which was consistent with cases in Ethiopia, Greenland, and Australia. Programs engaging volunteers were more frequently reported as ongoing, but those involving digital data entry were less often sustained when data collectors were volunteers. For the Vietnamese and Canadian cases, sustainability was undermined by a mismatch in stakeholder objectives. In the Ghanaian case, complex field protocols diminished monitoring sustainability. Innovative technologies attract interest, but the foundation of effective participatory adaptive monitoring depends more on collaboratively defined questions, objectives, conceptual models, and monitoring approaches. When this foundation is built through effective partnerships, digital data entry can enable the collection of more data of higher quality. Without this foundation, or when implemented ineffectively or unnecessarily, digital data entry can be an additional expense that distracts from core monitoring objectives

  1. Overview of entry risk predictions

    NASA Astrophysics Data System (ADS)

    Mrozinski, R.; Mendeck, G.; Cutri-Kohart, R.

    Risk to people on the ground from uncontrolled entries of spacecraft is a primary concern when analyzing end-of-life disposal options for satellites. Countries must balance this risk with the need to mitigate an exponentially growing space debris population. Currently the United States does this via guidelines that call for a satellite to be disposed of in a controlled manner if an uncontrolled entry would be too risky to people on the ground. This risk is measured by a quantity called "casualty expectation", or E , where casualty expectation is defined as the expectedc number of people suffering death or injury due to a spacecraft entry event. If Ec exceeds 1 in 10,000, U. S. guidelines state that the entry should be controlled rather than uncontrolled. Since this guideline can have serious impacts on the cost, lifetime, and even the mission and functionality of a satellite, it is critical that this quantity be estimated well, and decision makers understand all assumptions and limitations inherent in the resulting value. This paper discusses several issues regarding estimates of casualty expectation, beginning with an overview of relevant United States policies and guidelines. The equation the space industry typically uses to estimate casualty expectation is presented, along with a look at the sensitivity of the results to the typical assumptions, models, and initial condition uncertainties. Differences in these modeling issues with respect to launch failure Ec estimates are included in the discussion. An alternate quantity to assess risks due to spacecraft entries is introduced. "Probability of casualty", or Pc , is defined as the probability of one or more instances of people suffering death or injury due to a spacecraft entry event. The equation to estimate Pc is derived, where the same assumptions, modeling, and initial condition issues for Ec apply. Several examples are then given of both Ec and Pc estimate calculations. Due to the difficult issues in

  2. 32 CFR 809a.3 - Unauthorized entry.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Unauthorized entry. 809a.3 Section 809a.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION INSTALLATION ENTRY POLICY, CIVIL DISTURBANCE INTERVENTION AND DISASTER ASSISTANCE Installation Entry Policy §...

  3. 19 CFR 122.42 - Aircraft entry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Aircraft entry. 122.42 Section 122.42 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements...

  4. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  5. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  6. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  7. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  8. 32 CFR 770.18 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.18 Entry restrictions. Except for military personnel and civilian employees of the United States in the performance of their official duties, entry upon Naval Submarine Base,...

  9. 32 CFR 770.51 - Entry procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Entry procedures. 770.51 Section 770.51 National... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.51 Entry procedures. (a) Any person or group of persons desiring the advance consent of...

  10. 32 CFR 770.51 - Entry procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Entry procedures. 770.51 Section 770.51 National... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.51 Entry procedures. (a) Any person or group of persons desiring the advance consent of...

  11. 32 CFR 770.51 - Entry procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Entry procedures. 770.51 Section 770.51 National... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.51 Entry procedures. (a) Any person or group of persons desiring the advance consent of...

  12. 32 CFR 770.51 - Entry procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Entry procedures. 770.51 Section 770.51 National... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Puget Sound Naval Shipyard, Bremerton, Washington § 770.51 Entry procedures. (a) Any person or group of persons desiring the advance consent of...

  13. 32 CFR 763.4 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Entry restrictions. 763.4 Section 763.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY ISLANDS UNDER NAVY JURISDICTION RULES GOVERNING PUBLIC ACCESS Entry Regulations for Kaho'olawe Island, Hawaii § 763.4 Entry restrictions....

  14. 19 CFR 122.42 - Aircraft entry.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Aircraft entry. 122.42 Section 122.42 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing...

  15. 19 CFR 122.42 - Aircraft entry.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Aircraft entry. 122.42 Section 122.42 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing...

  16. 19 CFR 122.42 - Aircraft entry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Aircraft entry. 122.42 Section 122.42 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing...

  17. 19 CFR 122.42 - Aircraft entry.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Aircraft entry. 122.42 Section 122.42 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing...

  18. 10 CFR 1048.3 - Unauthorized entry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Unauthorized entry. 1048.3 Section 1048.3 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) TRESPASSING ON STRATEGIC PETROLEUM RESERVE FACILITIES AND OTHER PROPERTY § 1048.3 Unauthorized entry. Unauthorized entry into or upon an SPR facility or real...

  19. 10 CFR 1048.3 - Unauthorized entry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Unauthorized entry. 1048.3 Section 1048.3 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) TRESPASSING ON STRATEGIC PETROLEUM RESERVE FACILITIES AND OTHER PROPERTY § 1048.3 Unauthorized entry. Unauthorized entry into or upon an SPR facility or real...

  20. Deletion of Prepl Causes Growth Impairment and Hypotonia in Mice

    PubMed Central

    Lone, Anna Mari; Leidl, Mathias; McFedries, Amanda K.; Horner, James W.; Creemers, John; Saghatelian, Alan

    2014-01-01

    Genetic studies of rare diseases can identify genes of unknown function that strongly impact human physiology. Prolyl endopeptidase-like (PREPL) is an uncharacterized member of the prolyl peptidase family that was discovered because of its deletion in humans with hypotonia-cystinuria syndrome (HCS). HCS is characterized by a number of physiological changes including diminished growth and neonatal hypotonia or low muscle tone. HCS patients have deletions in other genes as well, making it difficult to tease apart the specific role of PREPL. Here, we develop a PREPL null (PREPL−/−) mouse model to address the physiological role of this enzyme. Deletion of exon 11 from the Prepl gene, which encodes key catalytic amino acids, leads to a loss of PREPL protein as well as lower Prepl mRNA levels. PREPL−/− mice have a pronounced growth phenotype, being significantly shorter and lighter than their wild type (PREPL+/+) counterparts. A righting assay revealed that PREPL−/− pups took significantly longer than PREPL+/+ pups to right themselves when placed on their backs. This deficit indicates that PREPL−/− mice suffer from neonatal hypotonia. According to these results, PREPL regulates growth and neonatal hypotonia in mice, which supports the idea that PREPL causes diminished growth and neonatal hypotonia in humans with HCS. These animals provide a valuable asset in deciphering the underlying biochemical, cellular and physiological pathways that link PREPL to HCS, and this may eventually lead to new insights in the treatment of this disease. PMID:24586561

  1. [Keynote address: Climate change

    SciTech Connect

    Forrister, D.

    1994-12-31

    Broadly speaking, the climate issue is moving from talk to action both in the United States and internationally. While few nations have adopted strict controls or stiff new taxes, a number of them are developing action plans that are making clear their intention to ramp up activity between now and the year 2000... and beyond. There are sensible, economically efficient strategies to be undertaken in the near term that offer the possibility, in many countries, to avoid more draconian measures. These strategies are by-and-large the same measures that the National Academy of Sciences recommended in a 1991 report called, Policy Implications of Greenhouse Warming. The author thinks the Academy`s most important policy contribution was how it recommended the nations act in the face of uncertain science and high risks--that cost effective measures are adopted as cheap insurance... just as nations insure against other high risk, low certainty possibilities, like catastrophic health insurance, auto insurance, and fire insurance. This insurance theme is still right. First, the author addresses how the international climate change negotiations are beginning to produce insurance measures. Next, the author will discuss some of the key issues to watch in those negotiations that relate to longer-term insurance. And finally, the author will report on progress in the United States on the climate insurance plan--The President`s Climate Action Plan.

  2. 19 CFR 143.36 - Form of immediate delivery, entry and entry summary.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Form of immediate delivery, entry and entry summary. (a) Electronic form of data. If Customs determines... 19 Customs Duties 2 2011-04-01 2011-04-01 false Form of immediate delivery, entry and entry summary. 143.36 Section 143.36 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF...

  3. 76 FR 82315 - Agency Information Collection Activities: Entry/Immediate Delivery Application and Simplified Entry

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... Delivery Application and Simplified Entry AGENCY: U.S. Customs and Border Protection, Department of... Delivery Application (Forms 3461 and 3461 ALT) and Simplified Entry. This is a proposed revision and... forms of information. Title: Entry/Immediate Delivery Application and Simplified Entry. OMB Number:...

  4. Re-entry residency training

    PubMed Central

    Jamieson, Jean L.; Webber, Eric M.; Sivertz, Kristin S.

    2010-01-01

    ABSTRACT OBJECTIVE To identify and quantify the reasons general practitioners and family physicians consider retraining and their reasons for not pursuing further training. DESIGN Population-based mailed survey. SETTING British Columbia. PARTICIPANTS Family physicians and general practitioners identified by the College of Physicians and Surgeons of British Columbia. MAIN OUTCOME MEASURES Practising physicians’ level of awareness of the University of British Columbia’s re-entry training program, the number and demographic characteristics of those who had considered retraining, their specialties of interest, and the barriers and possible inducements to retraining. RESULTS Only half of the survey respondents were aware of the re-entry training program at the University of British Columbia. A small but substantial number of practising general practitioners and family physicians were interested in taking specialty training from the Royal College of Physicians and Surgeons of Canada. While several training programs were particularly popular (ie, anesthesia and psychiatry—18.5% of respondents for each), almost every specialty training program was mentioned. Physicians identified the length and hours of training, financial issues, family issues, and the need for relocation as obstacles to retraining. The availability of part-time training, regional training, and return-of-service financial assistance were all identified as potential inducements. CONCLUSION To meet the needs of practising physicians, re-entry training programs will need to consider flexibility, where feasible, with regard to choice of specialty, intensity, and location of postgraduate training. PMID:20547505

  5. Fragmentation and ablation during entry

    SciTech Connect

    Canavan, G.H.

    1997-09-01

    This note discusses objects that both fragment and ablate during entry, using the results of previous reports to describe the velocity, pressure, and fragmentation of entering objects. It shows that the mechanisms used there to describe the breakup of non-ablating objects during deceleration remain valid for most ablating objects. It treats coupled fragmentation and ablation during entry, building on earlier models that separately discuss the entry of objects that are hard, whose high heat of ablation permits little erosion, and those who are strong whose strength prevents fragmentation, which are discussed in ``Radiation from Hard Objects,`` ``Deceleration and Radiation of Strong, Hard, Asteroids During Atmospheric Impact,`` and ``Meteor Signature Interpretation.`` This note provides a more detailed treatment of the further breakup and separation of fragments during descent. It replaces the constraint on mass per unit area used earlier to determine the altitude and magnitude of peak power radiation with a detailed analytic solution of deceleration. Model predictions are shown to be in agreement with the key features of numerical calculations of deceleration. The model equations are solved for the altitudes of maximum radiation, which agree with numerical integrations. The model is inverted analytically to infer object size and speed from measurements of peak power and altitude to provide a complete model for the approximate inversion of meteor data.

  6. The Hera Saturn entry probe mission

    NASA Astrophysics Data System (ADS)

    Mousis, O.; Atkinson, D. H.; Spilker, T.; Venkatapathy, E.; Poncy, J.; Frampton, R.; Coustenis, A.; Reh, K.; Lebreton, J.-P.; Fletcher, L. N.; Hueso, R.; Amato, M. J.; Colaprete, A.; Ferri, F.; Stam, D.; Wurz, P.; Atreya, S.; Aslam, S.; Banfield, D. J.; Calcutt, S.; Fischer, G.; Holland, A.; Keller, C.; Kessler, E.; Leese, M.; Levacher, P.; Morse, A.; Muñoz, O.; Renard, J.-B.; Sheridan, S.; Schmider, F.-X.; Snik, F.; Waite, J. H.; Bird, M.; Cavalié, T.; Deleuil, M.; Fortney, J.; Gautier, D.; Guillot, T.; Lunine, J. I.; Marty, B.; Nixon, C.; Orton, G. S.; Sánchez-Lavega, A.

    2016-10-01

    The Hera Saturn entry probe mission is proposed as an M-class mission led by ESA with a contribution from NASA. It consists of one atmospheric probe to be sent into the atmosphere of Saturn, and a Carrier-Relay spacecraft. In this concept, the Hera probe is composed of ESA and NASA elements, and the Carrier-Relay Spacecraft is delivered by ESA. The probe is powered by batteries, and the Carrier-Relay Spacecraft is powered by solar panels and batteries. We anticipate two major subsystems to be supplied by the United States, either by direct procurement by ESA or by contribution from NASA: the solar electric power system (including solar arrays and the power management and distribution system), and the probe entry system (including the thermal protection shield and aeroshell). Hera is designed to perform in situ measurements of the chemical and isotopic compositions as well as the dynamics of Saturn's atmosphere using a single probe, with the goal of improving our understanding of the origin, formation, and evolution of Saturn, the giant planets and their satellite systems, with extrapolation to extrasolar planets. Hera's aim is to probe well into the cloud-forming region of the troposphere, below the region accessible to remote sensing, to the locations where certain cosmogenically abundant species are expected to be well mixed. By leading to an improved understanding of the processes by which giant planets formed, including the composition and properties of the local solar nebula at the time and location of giant planet formation, Hera will extend the legacy of the Galileo and Cassini missions by further addressing the creation, formation, and chemical, dynamical, and thermal evolution of the giant planets, the entire solar system including Earth and the other terrestrial planets, and formation of other planetary systems.

  7. Coupling approaches used in atmospheric entry models

    NASA Astrophysics Data System (ADS)

    Gritsevich, M. I.

    2012-09-01

    While a planet orbits the Sun, it is subject to impact by smaller objects, ranging from tiny dust particles and space debris to much larger asteroids and comets. Such collisions have taken place frequently over geological time and played an important role in the evolution of planets and the development of life on the Earth. Though the search for near-Earth objects addresses one of the main points of the Asteroid and Comet Hazard, one should not underestimate the useful information to be gleaned from smaller atmospheric encounters, known as meteors or fireballs. Not only do these events help determine the linkages between meteorites and their parent bodies; due to their relative regularity they provide a good statistical basis for analysis. For successful cases with found meteorites, the detailed atmospheric path record is an excellent tool to test and improve existing entry models assuring the robustness of their implementation. There are many more important scientific questions meteoroids help us to answer, among them: Where do these objects come from, what are their origins, physical properties and chemical composition? What are the shapes and bulk densities of the space objects which fully ablate in an atmosphere and do not reach the planetary surface? Which values are directly measured and which are initially assumed as input to various models? How to couple both fragmentation and ablation effects in the model, taking real size distribution of fragments into account? How to specify and speed up the recovery of a recently fallen meteorites, not letting weathering to affect samples too much? How big is the pre-atmospheric projectile to terminal body ratio in terms of their mass/volume? Which exact parameters beside initial mass define this ratio? More generally, how entering object affects Earth's atmosphere and (if applicable) Earth's surface? How to predict these impact consequences based on atmospheric trajectory data? How to describe atmospheric entry

  8. 1p36 deletion syndrome: an update.

    PubMed

    Jordan, Valerie K; Zaveri, Hitisha P; Scott, Daryl A

    2015-01-01

    Deletions of chromosome 1p36 affect approximately 1 in 5,000 newborns and are the most common terminal deletions in humans. Medical problems commonly caused by terminal deletions of 1p36 include developmental delay, intellectual disability, seizures, vision problems, hearing loss, short stature, distinctive facial features, brain anomalies, orofacial clefting, congenital heart defects, cardiomyopathy, and renal anomalies. Although 1p36 deletion syndrome is considered clinically recognizable, there is significant phenotypic variation among affected individuals. This variation is due, at least in part, to the genetic heterogeneity seen in 1p36 deletions which include terminal and interstitial deletions of varying lengths located throughout the 30 Mb of DNA that comprise chromosome 1p36. Array-based copy number variant analysis can easily identify genomic regions of 1p36 that are deleted in an affected individual. However, predicting the phenotype of an individual based solely on the location and extent of their 1p36 deletion remains a challenge since most of the genes that contribute to 1p36-related phenotypes have yet to be identified. In addition, haploinsufficiency of more than one gene may contribute to some phenotypes. In this article, we review recent successes in the effort to map and identify the genes and genomic regions that contribute to specific 1p36-related phenotypes. In particular, we highlight evidence implicating MMP23B, GABRD, SKI, PRDM16, KCNAB2, RERE, UBE4B, CASZ1, PDPN, SPEN, ECE1, HSPG2, and LUZP1 in various 1p36 deletion phenotypes.

  9. 1p36 deletion syndrome: an update

    PubMed Central

    Jordan, Valerie K; Zaveri, Hitisha P; Scott, Daryl A

    2015-01-01

    Deletions of chromosome 1p36 affect approximately 1 in 5,000 newborns and are the most common terminal deletions in humans. Medical problems commonly caused by terminal deletions of 1p36 include developmental delay, intellectual disability, seizures, vision problems, hearing loss, short stature, distinctive facial features, brain anomalies, orofacial clefting, congenital heart defects, cardiomyopathy, and renal anomalies. Although 1p36 deletion syndrome is considered clinically recognizable, there is significant phenotypic variation among affected individuals. This variation is due, at least in part, to the genetic heterogeneity seen in 1p36 deletions which include terminal and interstitial deletions of varying lengths located throughout the 30 Mb of DNA that comprise chromosome 1p36. Array-based copy number variant analysis can easily identify genomic regions of 1p36 that are deleted in an affected individual. However, predicting the phenotype of an individual based solely on the location and extent of their 1p36 deletion remains a challenge since most of the genes that contribute to 1p36-related phenotypes have yet to be identified. In addition, haploinsufficiency of more than one gene may contribute to some phenotypes. In this article, we review recent successes in the effort to map and identify the genes and genomic regions that contribute to specific 1p36-related phenotypes. In particular, we highlight evidence implicating MMP23B, GABRD, SKI, PRDM16, KCNAB2, RERE, UBE4B, CASZ1, PDPN, SPEN, ECE1, HSPG2, and LUZP1 in various 1p36 deletion phenotypes. PMID:26345236

  10. Atmospheric Entry Experiments at IRS

    NASA Astrophysics Data System (ADS)

    Auweter-Kurtz, M.; Endlich, P.; Herdrich, G.; Kurtz, H.; Laux, T.; Löhle, S.; Nazina, N.; Pidan, S.

    2002-01-01

    Entering the atmosphere of celestial bodies, spacecrafts encounter gases at velocities of several km/s, thereby being subjected to great heat loads. The thermal protection systems and the environment (plasma) have to be investigated by means of computational and ground facility based simulations. For more than a decade, plasma wind tunnels at IRS have been used for the investigation of TPS materials. Nevertheless, ground tests and computer simulations cannot re- place space flights completely. Particularly, entry mission phases encounter challenging problems, such as hypersonic aerothermodynamics. Concerning the TPS, radiation-cooled materials used for reuseable spacecrafts and ablator tech- nologies are of importance. Besides the mentioned technologies, there is the goal to manage guidance navigation, con- trol, landing technology and inflatable technologies such as ballutes that aim to keep vehicles in the atmosphere without landing. The requirement to save mass and energy for planned interplanetary missions such as Mars Society Balloon Mission, Mars Sample Return Mission, Mars Express or Venus Sample Return mission led to the need for manoeuvres like aerocapture, aero-breaking and hyperbolic entries. All three are characterized by very high kinetic vehicle energies to be dissipated by the manoeuvre. In this field flight data are rare. The importance of these manoeuvres and the need to increase the knowledge of required TPS designs and behavior during such mission phases point out the need of flight experiments. As result of the experience within the plasma diagnostic tool development and the plasma wind tunnel data base, flight experiments like the PYrometric RE-entry EXperiment PYREX were developed, fully qualified and successfully flown. Flight experiments such as the entry spectrometer RESPECT and PYREX on HOPE-X are in the conceptual phase. To increase knowledge in the scope of atmospheric manoeuvres and entries, data bases have to be created combining both

  11. 78 FR 21916 - Procurement List; Proposed Additions and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... Commissaryagency (DECA), Fort Lee, VA Deletions The following products and service are proposed for deletion from... Activity: Defense Commissaryagency (DECA), Fort Lee, VA Barry S. Lineback, Director, Business...

  12. The interaction between claudin-1 and dengue viral prM/M protein for its entry.

    PubMed

    Che, Pulin; Tang, Hengli; Li, Qianjun

    2013-11-01

    Dengue disease is becoming a huge public health concern around the world as more than one-third of the world's population living in areas at risk of infection. In an effort to assess host factors interacting with dengue virus, we identified claudin-1, a major tight junction component, as an essential cell surface protein for dengue virus entry. When claudin-1 was knocked down in Huh 7.5 cells via shRNA, the amount of dengue virus entering host cells was reduced. Consequently, the progeny virus productions were decreased and dengue virus-induced CPE was prevented. Furthermore, restoring the expression of claudin-1 in the knockdown cells facilitated dengue virus entry. The interaction between claudin-1 and dengue viral prM protein was further demonstrated using the pull-down assay. Deletion of the extracellular loop 1 (ECL1) of claudin-1 abolished such interaction, so did point mutations C54A, C64A and I32M on ECL1. These results suggest that the interaction between viral protein prM and host protein claudin-1 was essential for dengue entry. Since host and viral factors involved in virus entry are promising therapeutic targets, determining the essential role of claudin-1 could lead to the discovery of entry inhibitors with attractive therapeutic potential against dengue disease.

  13. The Phys4Entry database

    NASA Astrophysics Data System (ADS)

    Laricchiuta, Annarita

    2012-10-01

    The Phys4Entry DB is a database of state-selected dynamical information for elementary processes relevant to the state-to-state kinetic modeling of planetary-atmosphere entry conditions. The DB is intended to the challenging goal of complementing the information in the existing web-access databases, collecting and validating data of collisional dynamics of elementary processes involving ground and excited chemical species, with resolution on the electronic, vibrational and rotational degrees of freedom. Four relevant classes of elementary processes are considered, i.e. electron-molecule collisions, atom/molecule-molecule collisions, atom/molecule surface interaction and photon-induced processes, constructing a taxonomy for process classification. Data populating the DB are largely originated by the coordinated research activity done in the frame of the Phys4Entry FP7 project, considering different theoretical approaches from quantum to semi-classical or quasi-classical molecular dynamics. Nevertheless the results, obtained in the Bari plasma chemistry labs in years of research devoted to the construction of reliable state-to-state kinetic models for hydrogen and air plasmas, are also transferred to the DB. Two DB interfaces have been created for different roles allowed to different actions: the contributor, uploading new processes, and the inquirer, submitting queries, to access the complete information about the records, through a graphical tool, displaying energy or roto-vibrational dependence of dynamical data, or through the export action to download ascii datafiles. The DB is expected to have a significant impact on the modeling community working also in scientific fields different from the aerothermodynamics (i.e. fusion, environment, ), making practicable the state-to-state approach.

  14. Atlas F entry aerothermic study

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The feasibility of obtaining heat transfer data on an expended Atlas F booster launch vehicle was investigated in the altitude range of 300,000 to 200,000 feet during entry conditions, with a velocity in the range of 20,000 to 25,000 feet per second, and through a range of vehicle attitudes of plus or minus 90 degrees. These data are desired for correlation with turbulent heat transfer and boundary layer transition data obtained from wind tunnel test facilities. The data would also be valuable in assessing rarified gas and surface catalicity effects in a real gas environment.

  15. The Reach Address Database (RAD)

    EPA Pesticide Factsheets

    The Reach Address Database (RAD) stores reach address information for each Water Program feature that has been linked to the underlying surface water features (streams, lakes, etc) in the National Hydrology Database (NHD) Plus dataset.

  16. Overview of entry risk predictions

    NASA Astrophysics Data System (ADS)

    Mrozinski, R. B.; Mendeck, G. F.; Cutri-Kohart, R. M.

    2004-01-01

    This paper discusses many aspects of "casualty expectation", defined as the expected number of people suffering death or injury due to a spacecraft entry event, normally used when planning the end-of-life disposal of satellites. United States guidelines state a disposal via atmospheric entry should be controlled rather than uncontrolled whenever casualty expectation estimates exceed a specified limit. Since this guideline can have serious impacts on the cost, lifetime, and even the mission and functionality of a satellite, it is critical that casualty expectation ( Ec) be estimated well, and decision-makers understand all assumptions and limitations inherent in the result. This paper begins with an overview of relevant United States guidelines. The equation the space industry typically uses to estimate Ec is presented, along with its sensitivity to typical assumptions, models, and initial condition uncertainties. An alternate quantity is introduced, called "probability of casualty", or Pc. Two examples are given of both Ec and Pc estimations. Because Ec and Pc are dependent on variables with significant uncertainty, confidence in the estimates themselves can be challenged. Fortunately, a precise value is rarely needed. Results typically are well above or well below guideline limits to the extent that even if all variable values were certain, the resulting recommended course of action would not change. Ec and Pc are then ideal to use in relative analyses using a standard tool to assess compliance with guidelines.

  17. Low levels of LTR retrotransposon deletion by ectopic recombination in the gigantic genomes of salamanders.

    PubMed

    Frahry, Matthew Blake; Sun, Cheng; Chong, Rebecca A; Mueller, Rachel Lockridge

    2015-02-01

    Across the tree of life, species vary dramatically in nuclear genome size. Mutations that add or remove sequences from genomes-insertions or deletions, or indels-are the ultimate source of this variation. Differences in the tempo and mode of insertion and deletion across taxa have been proposed to contribute to evolutionary diversity in genome size. Among vertebrates, most of the largest genomes are found within the salamanders, an amphibian clade with genome sizes ranging from ~14 to ~120 Gb. Salamander genomes have been shown to experience slower rates of DNA loss through small (i.e., <30 bp) deletions than do other vertebrate genomes. However, no studies have addressed DNA loss from salamander genomes resulting from larger deletions. Here, we focus on one type of large deletion-ectopic-recombination-mediated removal of LTR retrotransposon sequences. In ectopic recombination, double-strand breaks are repaired using a "wrong" (i.e., ectopic, or non-allelic) template sequence-typically another locus of similar sequence. When breaks occur within the LTR portions of LTR retrotransposons, ectopic-recombination-mediated repair can produce deletions that remove the internal transposon sequence and the equivalent of one of the two LTR sequences. These deletions leave a signature in the genome-a solo LTR sequence. We compared levels of solo LTRs in the genomes of four salamander species with levels present in five vertebrates with smaller genomes. Our results demonstrate that salamanders have low levels of solo LTRs, suggesting that ectopic-recombination-mediated deletion of LTR retrotransposons occurs more slowly than in other vertebrates with smaller genomes.

  18. Optimal firm growth under the threat of entry.

    PubMed

    Kort, Peter M; Wrzaczek, Stefan

    2015-10-01

    The paper studies the incumbent-entrant problem in a fully dynamic setting. We find that under an open-loop information structure the incumbent anticipates entry by overinvesting, whereas in the Markov perfect equilibrium the incumbent slightly underinvests in the period before the entry. The entry cost level where entry accommodation passes into entry deterrence is lower in the Markov perfect equilibrium. Further we find that the incumbent's capital stock level needed to deter entry is hump shaped as a function of the entry time, whereas the corresponding entry cost, where the entrant is indifferent between entry and non-entry, is U-shaped.

  19. Preventing re-entry to foster care.

    PubMed

    Carnochan, Sarah; Rizik-Baer, Daniel; Austin, Michael J

    2013-01-01

    Re-entry to foster care generally refers to circumstances in which children who have been discharged from foster care to be reunified with their family of origin, adopted, or provided kinship guardianship are returned to foster care. In the context of the federal performance measurement system, re-entry refers specifically to a return to foster care following an unsuccessful reunification. The federal Children and Family Services Review measures re-entry to foster care with a single indicator, called the permanency of reunification indicator, one of four indicators comprising the reunification composite measure. This review focuses on research related to the re-entry indicator, including the characteristics of children, caregivers and families, as well as case and child welfare services that are associated with a higher or lower risk of re-entry to foster care. Promising post-reunification services designed to prevent re-entry to foster care are described.

  20. Peer Relations at School Entry: Sex Differences in the Outcomes of Foster Care

    PubMed Central

    Leve, Leslie D.; Fisher, Philip A.; DeGarmo, David S.

    2008-01-01

    Converging research indicates that foster children with maltreatment histories have more behavior problems and poorer peer relations than biologically reared, nonmaltreated youth. However, little is known about whether such deficits in peer relations work independently or as a result of increased behavior problems, and whether outcomes for foster children differ by sex. To address these questions, multiagent methods were used to assess peer relations at school entry among maltreated foster children and a comparison sample of low-income, nonmaltreated, biologically reared children (N = 121). Controlling for caregiver-reported behavior problems prior to school entry, results from a multigroup SEM analysis suggested that there were significant relationships between foster care status and poor peer relations at school entry and between foster care status and the level of behavior problems prior to school entry for girls only. These Sex × Foster care status interactions suggest the need for gender-sensitive interventions with maltreated foster children. PMID:19234614

  1. Somatic mosaicism for a DMD gene deletion

    SciTech Connect

    Saito, Kayoko; Ikeya, Kiyoko; Kondo, Eri

    1995-03-13

    Mosaicism is a mixed state, with two cell populations of different genetic origins caused by a cell mutation occurring after fertilization. In the present case, DNA analysis of lymphocytes led to a DMD diagnosis before death. Postmortem immunocytochemical and DNA analysis showed somatic mosaicism. At age 18 years, blood lymphocyte DNA analysis showed a DMD gene deletion, upstream from exon 7 to the 5{prime} end containing both muscle and brain promoters. As the patient`s mother and elder sister had no deletions, he was considered to have a new mutation. Immunocytochemical studies of postmortem tissues showed that dystrophin was absent from the tongue, deltoid, intercostal, psoas and rectus femoris muscles, but there was a mix of dystrophin-positive and negative fibers in the rectus abdominis, cardiac, temporalis and sternocleidomastoid muscles. All diaphragm cells were dystrophin positive. Polymerase chain reaction (PCR) amplification from all tissues except the temporalis and sternocleidomastoid muscles, diaphragm and kidney, in which no deletion was found, showed the deletion from at least exon 6 to the 5{prime} end containing both muscle and brain promoters. In this case, a genomic deletion of the DMD gene contributed to the formation of tissues derived from both ectoderm and endoderm, and cells of mesodermal origin showed genotypic and phenotypic heterogeneity. Our results indicate a mutation of the present case may have occurred just before the period of germ layer formation. 34 refs., 7 figs.

  2. HADES PC network: an automated data entry system

    SciTech Connect

    Hegemann, D.L.

    1986-09-12

    Mound's Health Physics section is faced with an increasing need to store and retrieve radiological data. This need has been addressed by the Health Physics Automated Data Entry System (HADES) which assumed a full production status on April 1, 1986. Mound's Technical Computer Support group implemented HADES in a series of phases which allowed high priority needs to be immediately supported. As a result of the system's personal computer-based structure, additional capabilities such as automated data acquisition were easily brought on-line. Since its inception in the first quarter of 1984, HADES has matured into a cost-efficient automated data acquisition system for Mound's Health Physics section.

  3. Clinical molecular testing: subspecialty, entry-level or specialist certification?

    PubMed

    Lennon, Alan; Hu, Peter

    2011-01-01

    Some clinical laboratories require workers who have basic knowledge in molecular techniques (such as fluorescent in situ hybridization and polymerase chain reaction). Exclusively molecular diagnostic laboratories need workers to be competent in a variety of cutting edge molecular technologies, such as DNA sequencing, array-based comparative genomic hybridization, quantitative polymerase chain reaction, and many other techniques. Having only one certification for molecular biology at the entry level, as newly prescribed by the Board of Certification, doesn't accurately define the two very differently trained types of people these differing types of laboratories require. Creating a second molecular certification, at the specialist level, would address this issue positively.

  4. CONTENT-ADDRESSABLE MEMORY SYSTEMS,

    DTIC Science & Technology

    The utility of content -addressable memories (CAM’s) within a general purpose computing system is investigated. Word cells within CAM may be...addressed by the character of all or a part of cell contents . Multimembered sets of word cells may be addressed simultaneously. The distributed logical...package is developed which allows simulation of CAM commands within job programs run on the IBM 7090 and derives tallies of execution times corresponding to a particular realization of a CAM system . (Author)

  5. Monosomy 1p36 deletion syndrome.

    PubMed

    Gajecka, Marzena; Mackay, Katherine L; Shaffer, Lisa G

    2007-11-15

    Monosomy 1p36 results from a heterozygous deletion of the most distal chromosomal band on the short arm of chromosome 1. Occurring in approximately 1 in 5,000 live births, monosomy 1p36 is the most common terminal deletion observed in humans. Monosomy 1p36 is associated with mental retardation, developmental delay, hearing impairment, seizures, growth impairment, hypotonia, and heart defects. The syndrome is also characterized by several distinct dysmorphic features, including large anterior fontanels, microcephaly, brachycephaly, deep-set eyes, flat nose and nasal bridge, and pointed chin. Several genes have been proposed as causative for individual features of the phenotype. In addition, based upon molecular characterization of subjects with monosomy 1p36, several mechanisms for the generation and stabilization of terminal deletions have been proposed.

  6. Method for introducing unidirectional nested deletions

    DOEpatents

    Dunn, John J.; Quesada, Mark A.; Randesi, Matthew

    2001-01-01

    Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment in the context of a cloning vector which contains an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment. Also disclosed is a method for producing single-stranded DNA probes utilizing the same cloning vector. An optimal vector, PZIP is described. Methods for introducing unidirectional deletions into a terminal location of a cloned DNA sequence which is inserted into the vector of the present invention are also disclosed. These methods are useful for introducing deletions into either or both ends of a cloned DNA insert, for high throughput sequencing of any DNA of interest.

  7. 19 CFR 10.78 - Entry.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Entry. (a) No entry shall be required for fish or other marine products taken on the high seas by... or other products are brought into port by the taking vessel or are transferred at sea to another... enterprise conducted under the American flag by vessels of the United States on the high seas or in...

  8. 19 CFR 10.78 - Entry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Entry. (a) No entry shall be required for fish or other marine products taken on the high seas by... or other products are brought into port by the taking vessel or are transferred at sea to another... enterprise conducted under the American flag by vessels of the United States on the high seas or in...

  9. 19 CFR 10.78 - Entry.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Entry. (a) No entry shall be required for fish or other marine products taken on the high seas by... or other products are brought into port by the taking vessel or are transferred at sea to another... enterprise conducted under the American flag by vessels of the United States on the high seas or in...

  10. 19 CFR 10.78 - Entry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Entry. (a) No entry shall be required for fish or other marine products taken on the high seas by... or other products are brought into port by the taking vessel or are transferred at sea to another... enterprise conducted under the American flag by vessels of the United States on the high seas or in...

  11. 19 CFR 10.78 - Entry.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Entry. (a) No entry shall be required for fish or other marine products taken on the high seas by... or other products are brought into port by the taking vessel or are transferred at sea to another... enterprise conducted under the American flag by vessels of the United States on the high seas or in...

  12. 32 CFR 245.27 - Data entry.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Data entry. 245.27 Section 245.27 National... Under ESCAT § 245.27 Data entry. Aircraft will file IFR or VFR flight plans, assigned a discrete... entered in the remarks section of the flight plan. The EATPL number will be passed with flight plan...

  13. 32 CFR 245.27 - Data entry.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Data entry. 245.27 Section 245.27 National... Under ESCAT § 245.27 Data entry. Aircraft will file IFR or VFR flight plans, assigned a discrete... entered in the remarks section of the flight plan. The EATPL number will be passed with flight plan...

  14. 32 CFR 245.27 - Data entry.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Data entry. 245.27 Section 245.27 National... Under ESCAT § 245.27 Data entry. Aircraft will file IFR or VFR flight plans, assigned a discrete... entered in the remarks section of the flight plan. The EATPL number will be passed with flight plan...

  15. 32 CFR 245.27 - Data entry.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Data entry. 245.27 Section 245.27 National... Under ESCAT § 245.27 Data entry. Aircraft will file IFR or VFR flight plans, assigned a discrete... entered in the remarks section of the flight plan. The EATPL number will be passed with flight plan...

  16. 32 CFR 245.27 - Data entry.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Data entry. 245.27 Section 245.27 National... Under ESCAT § 245.27 Data entry. Aircraft will file IFR or VFR flight plans, assigned a discrete... entered in the remarks section of the flight plan. The EATPL number will be passed with flight plan...

  17. 21 CFR 1316.05 - Entry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Entry. 1316.05 Section 1316.05 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE ADMINISTRATIVE FUNCTIONS, PRACTICES, AND PROCEDURES Administrative Inspections § 1316.05 Entry. An inspection shall be carried out by an inspector. Any...

  18. 32 CFR 770.19 - Entry procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.19 Entry procedures. (a) Any person or group of persons desiring the advance consent of the... Commanding Officer, Naval Submarine Base, Bangor, 1100 Hunley Road, Silverdale, WA 98315. (b) Each...

  19. 32 CFR 770.19 - Entry procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.19 Entry procedures. (a) Any person or group of persons desiring the advance consent of the... Commanding Officer, Naval Submarine Base, Bangor, 1100 Hunley Road, Silverdale, WA 98315. (b) Each...

  20. 32 CFR 770.19 - Entry procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.19 Entry procedures. (a) Any person or group of persons desiring the advance consent of the... Commanding Officer, Naval Submarine Base, Bangor, 1100 Hunley Road, Silverdale, WA 98315. (b) Each...

  1. 32 CFR 770.19 - Entry procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.19 Entry procedures. (a) Any person or group of persons desiring the advance consent of the... Commanding Officer, Naval Submarine Base, Bangor, 1100 Hunley Road, Silverdale, WA 98315. (b) Each...

  2. 32 CFR 770.19 - Entry procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base, Bangor, Silverdale, Washington § 770.19 Entry procedures. (a) Any person or group of persons desiring the advance consent of the... Commanding Officer, Naval Submarine Base, Bangor, 1100 Hunley Road, Silverdale, WA 98315. (b) Each...

  3. Space X First Entry Sample Analysis

    NASA Technical Reports Server (NTRS)

    James, John T.

    2012-01-01

    The toxicological assessment of one sample collected on May 26, 2012 and returned to earth on May 31, 2012 was analyzed for pollutants that had offgassed into the Dragon capsule by the time of first entry operations performed by the ISS crew. The components identified in the first-entry sample and their contributions to the total T-value are shown.

  4. Specification of the Model 3 Entry Lexicon.

    ERIC Educational Resources Information Center

    Rhode, Mary

    The Model 3 communication skills lexicon consists of three lists of words developed by the Southwest Regional Laboratory (SWRL) for use in communication skills instruction in K-6. This report documents the procedures followed in compiling the entry lexicon, the first component of the Model 3 communication skills lexicon. The entry lexicon is…

  5. Magnetohydrodynamic Power Generation in the Laboratory Simulated Martian Entry Plasma

    NASA Technical Reports Server (NTRS)

    Vuskovic, L.; Popovic, S.; Drake, J.; Moses, R. W.

    2005-01-01

    This paper addresses the magnetohydrodynamic (MHD) conversion of the energy released during the planetary entry phase of an interplanetary vehicle trajectory. The effect of MHD conversion is multi-fold. It reduces and redirects heat transferred to the vehicle, and regenerates the dissipated energy in reusable and transportable form. A vehicle on an interplanetary mission carries about 10,000 kWh of kinetic energy per ton of its mass. This energy is dissipated into heat during the planetary atmospheric entry phase. For instance, the kinetic energy of Mars Pathfinder was about 4220 kWh. Based on the loss in velocity, Mars Pathfinder lost about 92.5% of that energy during the plasma-sustaining entry phase that is approximately 3900 kWh. An ideal MHD generator, distributed over the probe surface of Mars Pathfinder could convert more than 2000 kWh of this energy loss into electrical energy, which correspond to more than 50% of the kinetic energy loss. That means that the heat transferred to the probe surface can be reduced by at least 50% if the converted energy is adequately stored, or re-radiated, or directly used. Therefore, MHD conversion could act not only as the power generating, but also as the cooling process. In this paper we describe results of preliminary experiments with light and microwave emitters powered by model magnetohydrodynamic generators and discuss method for direct use of converted energy.

  6. Automated entry technologies for confined space work activities: A survey.

    PubMed

    Botti, Lucia; Ferrari, Emilio; Mora, Cristina

    2017-04-01

    Work in confined spaces poses a significant risk to workers and rescuers involved in the emergency response when an accident occurs. Despite several standards and regulations define the safety requirements for such activities, injuries, and fatalities still occur. Furthermore, the on-site inspections after accidents often reveal that both employers and employees fail to implement safe entry procedures. Removing the risk is possible by avoiding the worker entry, but many activities require the presence of the operator inside the confined space to perform manual tasks. The following study investigates the available technologies for hazardous confined space work activities, e.g., cleaning, inspecting, and maintenance tasks. The aim is to provide a systematic review of the automated solutions for high-risk activities in confined spaces, considering the non-man entry as the most effective confined space safety strategy. Second, this survey aims to provide suggestions for future research addressing the design of new technologies. The survey consists of about 60 papers concerning innovative technologies for confined space work activities. The document review shows that several solutions have been developed and automation can replace the workers for a limited number of hazardous tasks. Several activities still require the manual intervention due to the complex characteristics of confined spaces, e.g., to remove the remains of the automatic cleaning process from the bottom of a tank. The results show that available technologies require more flexibility to adapt to such occupational environments and further research is needed.

  7. Orion Entry Display Feeder and Interactions with the Entry Monitor System

    NASA Technical Reports Server (NTRS)

    Baird, Darren; Bernatovich, Mike; Gillespie, Ellen; Kadwa, Binaifer; Matthews, Dave; Penny, Wes; Zak, Tim; Grant, Mike; Bihari, Brian

    2010-01-01

    The Orion spacecraft is designed to return astronauts to a landing within 10 km of the intended landing target from low Earth orbit, lunar direct-entry, and lunar skip-entry trajectories. Al pile the landing is nominally controlled autonomously, the crew can fly precision entries manually in the event of an anomaly. The onboard entry displays will be used by the crew to monitor and manually fly the entry, descent, and landing, while the Entry Monitor System (EMS) will be used to monitor the health and status of the onboard guidance and the trajectory. The entry displays are driven by the entry display feeder, part of the Entry Monitor System (EMS). The entry re-targeting module, also part of the EMS, provides all the data required to generate the capability footprint of the vehicle at any point in the trajectory, which is shown on the Primary Flight Display (PFD). It also provides caution and warning data and recommends the safest possible re-designated landing site when the nominal landing site is no longer within the capability of the vehicle. The PFD and the EMS allow the crew to manually fly an entry trajectory profile from entry interface until parachute deploy having the flexibility to manually steer the vehicle to a selected landing site that best satisfies the priorities of the crew. The entry display feeder provides data from the ENIS and other components of the GNC flight software to the displays at the proper rate and in the proper units. It also performs calculations that are specific to the entry displays and which are not made in any other component of the flight software. In some instances, it performs calculations identical to those performed by the onboard primary guidance algorithm to protect against a guidance system failure. These functions and the interactions between the entry display feeder and the other components of the EMS are described.

  8. Deletion 22q13.3 syndrome.

    PubMed

    Phelan, Mary C

    2008-05-27

    The deletion 22q13.3 syndrome (deletion 22q13 syndrome or Phelan-McDermid syndrome) is a chromosome microdeletion syndrome characterized by neonatal hypotonia, global developmental delay, normal to accelerated growth, absent to severely delayed speech, and minor dysmorphic features. The deletion occurs with equal frequency in males and females and has been reported in mosaic and non-mosaic forms. Due to lack of clinical recognition and often insufficient laboratory testing, the syndrome is under-diagnosed and its true incidence remains unknown. Common physical traits include long eye lashes, large or unusual ears, relatively large hands, dysplastic toenails, full brow, dolicocephaly, full cheeks, bulbous nose, and pointed chin. Behavior is autistic-like with decreased perception of pain and habitual chewing or mouthing. The loss of 22q13.3 can result from simple deletion, translocation, ring chromosome formation and less common structural changes affecting the long arm of chromosome 22, specifically the region containing the SHANK3 gene. The diagnosis of deletion 22q13 syndrome should be considered in all cases of hypotonia of unknown etiology and in individuals with absent speech. Although the deletion can sometimes be detected by high resolution chromosome analysis, fluorescence in situ hybridization (FISH) or array comparative genomic hybridization (CGH) is recommended for confirmation. Differential diagnosis includes syndromes associated with hypotonia, developmental delay, speech delay and/or autistic-like affect (Prader-Willi, Angelman, Williams, Smith-Magenis, Fragile X, Sotos, FG, trichorhinophalangeal and velocardiofacial syndromes, autism spectrum disorders, cerebral palsy). Genetic counseling is recommended and parental laboratory studies should be considered to identify cryptic rearrangements and detect parental mosaicism. Prenatal diagnosis should be offered for future pregnancies in those families with inherited rearrangements. Individuals with

  9. 19 CFR 143.35 - Procedure for electronic entry summary.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Procedure for electronic entry summary. 143.35...; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing § 143.35 Procedure for electronic entry summary. In order to obtain entry summary processing electronically, the...

  10. 19 CFR 142.3 - Entry documentation required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry documentation required. 142.3 Section 142.3... TREASURY (CONTINUED) ENTRY PROCESS Entry Documentation § 142.3 Entry documentation required. (a) Contents. Except as provided in paragraph (b) of this section, the entry documentation required to secure...

  11. 19 CFR 143.35 - Procedure for electronic entry summary.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Procedure for electronic entry summary. 143.35...; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing § 143.35 Procedure for electronic entry summary. In order to obtain entry summary processing electronically, the...

  12. 50 CFR 91.22 - Display of contest entries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false Display of contest entries. 91.22 Section... Administering the Contest § 91.22 Display of contest entries. The Federal Duck Stamp Office assigns all eligible entries a number as entries are received. That office displays the entries in numerical order at...

  13. 50 CFR 91.22 - Display of contest entries.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Display of contest entries. 91.22 Section... Administering the Contest § 91.22 Display of contest entries. The Federal Duck Stamp Office assigns all eligible entries a number as entries are received. That office displays the entries in numerical order at...

  14. 50 CFR 91.22 - Display of contest entries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false Display of contest entries. 91.22 Section... Administering the Contest § 91.22 Display of contest entries. The Federal Duck Stamp Office assigns all eligible entries a number as entries are received. That office displays the entries in numerical order at...

  15. 50 CFR 91.22 - Display of contest entries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Display of contest entries. 91.22 Section... Administering the Contest § 91.22 Display of contest entries. The Federal Duck Stamp Office assigns all eligible entries a number as entries are received. That office displays the entries in numerical order at...

  16. 50 CFR 91.22 - Display of contest entries.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Display of contest entries. 91.22 Section... Administering the Contest § 91.22 Display of contest entries. The Federal Duck Stamp Office assigns all eligible entries a number as entries are received. That office displays the entries in numerical order at...

  17. 50 CFR 679.83 - Rockfish Program entry level fishery.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Rockfish Program entry level fishery. 679... ALASKA Rockfish Program § 679.83 Rockfish Program entry level fishery. (a) Rockfish entry level fishery—(1) General. A rockfish entry level harvester and rockfish entry level processor may participate...

  18. 50 CFR 679.83 - Rockfish Program entry level fishery.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Rockfish Program entry level fishery. 679... ALASKA Rockfish Program § 679.83 Rockfish Program entry level fishery. (a) Rockfish entry level fishery—(1) General. A rockfish entry level harvester and rockfish entry level processor may participate...

  19. Equilibrium radiative heating tables for Earth entry

    NASA Technical Reports Server (NTRS)

    Sutton, Kenneth; Hartung, Lin C.

    1990-01-01

    The recent resurgence of interest in blunt-body atmospheric entry for applications such as aeroassisted orbital transfer and planetary return has engendered a corresponding revival of interest in radiative heating. Radiative heating may be of importance in these blunt-body flows because of the highly energetic shock layer around the blunt nose. Sutton developed an inviscid, stagnation point, radiation coupled flow field code for investigating blunt-body atmospheric entry. The method has been compared with ground-based and flight data, and reasonable agreement has been found. To provide information for entry body studies in support of lunar and Mars return scenarios of interest in the 1970's, the code was exercised over a matrix of Earth entry conditions. Recently, this matrix was extended slightly to reflect entry vehicle designs of current interest. Complete results are presented.

  20. Thermal Soak Analysis of Earth Entry Vehicles

    NASA Technical Reports Server (NTRS)

    Agrawal, Parul; Sepka, Steven A.; Aliaga, Jose F.; Venkatapathy, Ethiraj; Samareh, Jamshid A.

    2012-01-01

    The Multi-Mission Earth Entry Vehicle project is developing an integrated tool called Multi Mission System Analysis for Planetary Entry Descent and Landing that will provide key technology solutions including mass sizing, aerodynamics, aerothermodynamics, and thermal and structural analysis for any given sample return mission. Thermal soak analysis and temperature predictions of various components including the payload container of the entry vehicle are part of the solution that this tool will offer to mission designers. The present paper focuses on the thermal soak analysis of an entry vehicle design based on the Mars Sample Return entry vehicle geometry and discusses a technical approach to develop parametric models for thermal soak analysis that will be integrated into the tool.

  1. SLO3 K+ channels control calcium entry through CATSPER channels in sperm.

    PubMed

    Chávez, Julio César; Ferreira, Juan José; Butler, Alice; De La Vega Beltrán, José Luis; Treviño, Claudia L; Darszon, Alberto; Salkoff, Lawrence; Santi, Celia M

    2014-11-14

    Here we show how a sperm-specific potassium channel (SLO3) controls Ca(2+) entry into sperm through a sperm-specific Ca(2+) channel, CATSPER, in a totally unanticipated manner. The genetic deletion of either of those channels confers male infertility in mice. During sperm capacitation SLO3 hyperpolarizes the sperm, whereas CATSPER allows Ca(2+) entry. These two channels may be functionally connected, but it had not been demonstrated that SLO3-dependent hyperpolarization is required for Ca(2+) entry through CATSPER channels, nor has a functional mechanism linking the two channels been shown. In this study we show that Ca(2+) entry through CATSPER channels is deficient in Slo3 mutant sperm lacking hyperpolarization; we also present evidence supporting the hypothesis that SLO3 channels activate CATSPER channels indirectly by promoting a rise in intracellular pH through a voltage-dependent mechanism. This mechanism may work through a Na(+)/H(+) exchanger (sNHE) and/or a bicarbonate transporter, which utilizes the inward driving force of the Na(+) gradient, rendering it intrinsically voltage-dependent. In addition, the sperm-specific Na(+)/H(+) exchanger (sNHE) possess a putative voltage sensor that might be activated by membrane hyperpolarization, thus increasing the voltage sensitivity of internal alkalization.

  2. Phenotypic variability in Angelman syndrome: comparison among different deletion classes and between deletion and UPD subjects.

    PubMed

    Varela, Monica Castro; Kok, Fernando; Otto, Paulo Alberto; Koiffmann, Celia Priszkulnik

    2004-12-01

    Angelman syndrome (AS) can result from either a 15q11-q13 deletion (del), paternal uniparental disomy (UPD), imprinting, or UBE3A mutations. Here, we describe the phenotypic and behavioral variability detected in 49 patients with different classes of deletions and nine patients with UPD. Diagnosis was made by methylation pattern analysis of exon 1 of the SNRPN-SNURF gene and by microsatellite profiling of loci within and outside the 15q11-q13 region. There were no major phenotypic differences between the two main classes (BP1-BP3; BP2-BP3) of AS deletion patients, except for the absence of vocalization, more prevalent in patients with BP1-BP3 deletions, and for the age of sitting without support, which was lower in patients with BP2-BP3 deletions. Our data suggest that gene deletions (NIPA1, NIPA2, CYF1P1, GCP5) mapped to the region between breakpoints BP1 and BP2 may be involved in the severity of speech impairment, since all BP1-BP3 deletion patients showed complete absence of vocalization, while 38.1% of the BP2-BP3 deletion patients were able to pronounce syllabic sounds, with doubtful meaning. Compared to UPD patients, deletion patients presented a higher incidence of swallowing disorders (73.9% del x 22.2% UPD) and hypotonia (73.3% del x 28.57% UPD). In addition, children with UPD showed better physical growth, fewer or no seizures, a lower incidence of microcephaly, less ataxia and higher cognitive skills. As a consequence of their milder or less typical phenotype, AS may remain undiagnosed, leading to an overall underdiagnosis of the disease.

  3. 78 FR 16521 - Agency Information Collection Activities: Declaration for Free Entry of Unaccompanied Articles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ..., Office of Management and Budget. Comments should be addressed to the OMB Desk Officer for U.S. Customs... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Declaration for Free Entry of Unaccompanied Articles AGENCY: U.S. Customs and Border Protection, Department of...

  4. 22q11 deletion syndrome: current perspective

    PubMed Central

    Hacıhamdioğlu, Bülent; Hacıhamdioğlu, Duygu; Delil, Kenan

    2015-01-01

    Chromosome 22q11 is characterized by the presence of chromosome-specific low-copy repeats or segmental duplications. This region of the chromosome is very unstable and susceptible to mutations. The misalignment of low-copy repeats during nonallelic homologous recombination leads to the deletion of the 22q11.2 region, which results in 22q11 deletion syndrome (22q11DS). The 22q11.2 deletion is associated with a wide variety of phenotypes. The term 22q11DS is an umbrella term that is used to encompass all 22q11.2 deletion-associated phenotypes. The haploinsufficiency of genes located at 22q11.2 affects the early morphogenesis of the pharyngeal arches, heart, skeleton, and brain. TBX1 is the most important gene for 22q11DS. This syndrome can ultimately affect many organs or systems; therefore, it has a very wide phenotypic spectrum. An increasing amount of information is available related to the pathogenesis, clinical phenotypes, and management of this syndrome in recent years. This review summarizes the current clinical and genetic status related to 22q11DS. PMID:26056486

  5. Nature of frequent deletions in CEBPA.

    PubMed

    Fuchs, Ota; Kostecka, Arnost; Provaznikova, Dana; Krasna, Blazena; Brezinova, Jana; Filkukova, Jitka; Kotlin, Roman; Kouba, Michal; Kobylka, Petr; Neuwirtova, Radana; Jonasova, Anna; Caniga, Miroslav; Schwarz, Jiri; Markova, Jana; Maaloufova, Jacqueline; Sponerova, Dana; Novakova, Ludmila; Cermak, Jaroslav

    2009-01-01

    C/EBPalpha (CCAAT/enhancer binding protein alpha) belongs to the family of leucine zipper transcription factors and is necessary for transcriptional control of granulocyte, adipocyte and hepatocyte differentiation, glucose metabolism and lung development. C/EBPalpha is encoded by an intronless gene. CEBPA mutations cause a myeloid differentiation block and were detected in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), multiple myeloma and non-Hodgkin's lymphoma (NHL) patients. In this study we identified in 41 individuals from 824 screened individuals (290 AML patients, 382 MDS patients, 56 NHL patients and 96 healthy individuals) a single class of 23 deletions in CEBPA gene which involved a direct repeat of at least 2 bp. These mutations are characterised by the loss of one of two same repeats at the ends of deleted sequence. Three most frequent repeats included in these deletions in CEBPA gene are CGCGAG (493-498_865-870), GCCAAGCAGC (508-517_907-916) and GG (486-487_885-886), all according to GenBank accession no. NM_004364.2. A mechanism for deletion formation between two repetitive sequences can be recombination events in the repair process. Double-stranded cut in DNA can initiate these recombination events of adjacent DNA sequences.

  6. Deletion 5q35.3

    SciTech Connect

    Stratton, R.F.; Tedrowe, N.A.; Tolworthy, J.A.; Patterson, R.M.; Ryan, S.G.; Young, R.S.

    1994-06-01

    The authors report on a 15-month-old boy with a de novo deletion of the terminal band of 5q, macrocephaly, mild retrognathia, anteverted nares with low flat nasal bridge, telecanthus, minor earlobe anomalies, bellshaped chest, diastasis recti, short fingers, and mild developmental delay.

  7. Viral cell recognition and entry.

    PubMed Central

    Rossmann, M. G.

    1994-01-01

    Rhinovirus infection is initiated by the recognition of a specific cell-surface receptor. The major group of rhinovirus serotypes attach to intercellular adhesion molecule-1 (ICAM-1). The attachment process initiates a series of conformational changes resulting in the loss of genomic RNA from the virion. X-ray crystallography and sequence comparisons suggested that a deep crevice or canyon is the site on the virus recognized by the cellular receptor molecule. This has now been verified by electron microscopy of human rhinovirus 14 (HRV14) and HRV16 complexed with a soluble component of ICAM-1. A hydrophobic pocket underneath the canyon is the site of binding of various hydrophobic drug compounds that can inhibit attachment and uncoating. This pocket is also associated with an unidentified, possibly cellular in origin, "pocket factor." The pocket factor binding site overlaps the binding site of the receptor. It is suggested that competition between the pocket factor and receptor regulates the conformational changes required for the initiation of the entry of the genomic RNA into the cell. PMID:7849588

  8. LABORATORY VOICE DATA ENTRY SYSTEM.

    SciTech Connect

    PRAISSMAN,J.L.SUTHERLAND,J.C.

    2003-04-01

    We have assembled a system using a personal computer workstation equipped with standard office software, an audio system, speech recognition software and an inexpensive radio-based wireless microphone that permits laboratory workers to enter or modify data while performing other work. Speech recognition permits users to enter data while their hands are holding equipment or they are otherwise unable to operate a keyboard. The wireless microphone allows unencumbered movement around the laboratory without a ''tether'' that might interfere with equipment or experimental procedures. To evaluate the potential of voice data entry in a laboratory environment, we developed a prototype relational database that records the disposal of radionuclides and/or hazardous chemicals Current regulations in our laboratory require that each such item being discarded must be inventoried and documents must be prepared that summarize the contents of each container used for disposal. Using voice commands, the user enters items into the database as each is discarded. Subsequently, the program prepares the required documentation.

  9. Entry Guidance for the Reusable Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Lu, Ping

    1999-01-01

    The X-33 Advanced Technology Demonstrator is a half-scale prototype developed to test the key technologies needed for a full-scale single-stage reusable launch vehicle (RLV). The X-33 is a suborbital vehicle that will be launched vertically, and land horizontally. The goals of this research were to develop an alternate entry guidance scheme for the X-33 in parallel to the actual X-33 entry guidance algorithms, provide comparative and complementary study, and identify potential new ways to improve entry guidance performance. Toward these goals, the nominal entry trajectory is defined by a piecewise linear drag-acceleration-versus-energy profile, which is in turn obtained by the solution of a semi-analytical parameter optimization problem. The closed-loop guidance is accomplished by tracking the nominal drag profile with primarily bank-angle modulation on-board. The bank-angle is commanded by a single full-envelope nonlinear trajectory control law. Near the end of the entry flight, the guidance logic is switched to heading control in order to meet strict conditions at the terminal area energy management interface. Two methods, one on ground-track control and the other on heading control, were proposed and examined for this phase of entry guidance where lateral control is emphasized. Trajectory dispersion studies were performed to evaluate the effectiveness of the entry guidance algorithms against a number of uncertainties including those in propulsion system, atmospheric properties, winds, aerodynamics, and propellant loading. Finally, a new trajectory-regulation method is introduced at the end as a promising precision entry guidance method. The guidance principle is very different and preliminary application in X-33 entry guidance simulation showed high precision that is difficult to achieve by existing methods.

  10. Advances in spacecraft atmospheric entry guidance

    NASA Astrophysics Data System (ADS)

    Benito Manrique, Joel

    In order to advance entry guidance technology two different research areas have been explored with the objective of increasing the reachable landing area and the landing accuracy for future Mars missions. Currently only the northern hemisphere of Mars is available for landing due to its low elevation. Only low elevation landing sites have the necessary atmospheric density to allow landing using current Entry, Descent and Landing (EDL) technology. In order to reach most of the Ancient Highlands, the majority of the southern hemisphere, advanced EDL technology is needed in multiple fields, including entry guidance. The first research area is the definition and applications of reachable and controllable sets for entry. The definition of the reachable and controllable sets provides a framework for the study of the capabilities of an entry vehicle in a given planet. Reachable and controllable sets can be used to comprehensively characterize the envelope of trajectories that a vehicle can fly, the sites it can reach and the entry states that can be accommodated. The sets can also be used for the evaluation of trajectory planning algorithms and to assist in the selection of the entry or landing sites. In essence, the reachable and controllable sets offer a powerful vehicle and trajectory analysis and design framework that allows for better mission design choices. In order to illustrate the use of the sets, they are computed for a representative Mars mission using two different vehicle configurations. The sets characterize the impact of the vehicle configuration on the entry capability. Furthermore, the sets are used to find the best skip-entry trajectory for a return from the Moon mission, highlighting the utility of the sets in atmospheric maneuvers other than entry. The second research area is the development of the components of an entry guidance algorithm that allow high elevation landing and provide as well high landing accuracy. The approach taken follows the

  11. Entry, Descent, and Landing With Propulsive Deceleration

    NASA Technical Reports Server (NTRS)

    Palaszewski, Bryan

    2012-01-01

    The future exploration of the Solar System will require innovations in transportation and the use of entry, descent, and landing (EDL) systems at many planetary landing sites. The cost of space missions has always been prohibitive, and using the natural planetary and planet s moons atmospheres for entry, descent, and landing can reduce the cost, mass, and complexity of these missions. This paper will describe some of the EDL ideas for planetary entry and survey the overall technologies for EDL that may be attractive for future Solar System missions.

  12. Adjustable Bracket For Entry Of Welding Wire

    NASA Technical Reports Server (NTRS)

    Gilbert, Jeffrey L.; Gutow, David A.

    1993-01-01

    Wire-entry bracket on welding torch in robotic welding system provides for adjustment of angle of entry of welding wire over range of plus or minus 30 degrees from nominal entry angle. Wire positioned so it does not hide weld joint in view of through-the-torch computer-vision system part of robot-controlling and -monitoring system. Swiveling bracket also used on nonvision torch on which wire-feed-through tube interferes with workpiece. Angle simply changed to one giving sufficient clearance.

  13. Parachute design for Galileo Jupiter entry probe

    NASA Technical Reports Server (NTRS)

    Rodier, R. W.; Thuss, R. C.; Terhune, J. E.

    1981-01-01

    This paper discusses the parachute subsystem used on an atmospheric entry probe that will descend through the clouds of Jupiter. The entry probe is a part of the Galileo Project to be launched in 1985 aboard the Space Shuttle; the entry probe will encounter the planet in 1988. The parachute subsystem consists of a pilot parachute and a main parachute, and both are of conventional conical ribbon design. Key considerations in the design of the parachutes and a summary of the parachute subsystem test program, which includes two air drop tests and a systems drop test (balloon launched), are presented.

  14. Available hardware for automated entry control

    SciTech Connect

    Holmes, J.P.

    1990-11-01

    Automated entry control has become an increasingly important issue at facilities where budget constraints are limiting options for manned entry control points. Three questions are immediately raised when automated entry control is considered: What hardware is available How much does it cost How effective is it in maintaining security Ongoing work at Sandia National Labs is attempting to answer these questions and establish a data base for use by facility security managers working the problem of how to maintain security on a limited budget. 14 refs.

  15. Texting while driving: is speech-based text entry less risky than handheld text entry?

    PubMed

    He, J; Chaparro, A; Nguyen, B; Burge, R J; Crandall, J; Chaparro, B; Ni, R; Cao, S

    2014-11-01

    Research indicates that using a cell phone to talk or text while maneuvering a vehicle impairs driving performance. However, few published studies directly compare the distracting effects of texting using a hands-free (i.e., speech-based interface) versus handheld cell phone, which is an important issue for legislation, automotive interface design and driving safety training. This study compared the effect of speech-based versus handheld text entries on simulated driving performance by asking participants to perform a car following task while controlling the duration of a secondary text-entry task. Results showed that both speech-based and handheld text entries impaired driving performance relative to the drive-only condition by causing more variation in speed and lane position. Handheld text entry also increased the brake response time and increased variation in headway distance. Text entry using a speech-based cell phone was less detrimental to driving performance than handheld text entry. Nevertheless, the speech-based text entry task still significantly impaired driving compared to the drive-only condition. These results suggest that speech-based text entry disrupts driving, but reduces the level of performance interference compared to text entry with a handheld device. In addition, the difference in the distraction effect caused by speech-based and handheld text entry is not simply due to the difference in task duration.

  16. Stakeholder identification of advanced technology opportunities at international ports of entry

    SciTech Connect

    Parker, S.K.; Icerman, L.

    1997-01-01

    As part of the Advanced Technologies for International and Intermodal Ports of Entry (ATIPE) Project, a diverse group of stakeholders was engaged to help identify problems experienced at inland international border crossings, particularly those at the US-Mexican border. The fundamental issue at international ports of entry is reducing transit time through the required documentation and inspection processes. Examples of other issues or problems, typically manifested as time delays at border crossings, repeatedly mentioned by stakeholders include: (1) lack of document standardization; (2) failure to standardize inspection processes; (3) inadequate information and communications systems; (4) manual fee and tariff collection; (5) inconsistency of processes and procedures; and (6) suboptimal cooperation among governmental agencies. Most of these issues can be addressed to some extent by the development of advanced technologies with the objective of allowing ports of entry to become more efficient while being more effective. Three categories of technologies were unambiguously of high priority to port of entry stakeholders: (1) automated documentation; (2) systems integration; and (3) vehicle and cargo tracking. Together, these technologies represent many of the technical components necessary for pre-clearance of freight approaching international ports of entry. Integration of vehicle and cargo tracking systems with port of entry information and communications systems, as well as existing industry legacy systems, should further enable border crossings to be accomplished consistently with optimal processing times.

  17. 9 CFR 93.806 - Animals refused entry.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Elephants, Hippopotami, Rhinoceroses, and Tapirs § 93.806 Animals refused entry. Any elephant, hippopotamus, rhinoceros, or tapir refused entry into...

  18. 9 CFR 93.806 - Animals refused entry.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Elephants, Hippopotami, Rhinoceroses, and Tapirs § 93.806 Animals refused entry. Any elephant, hippopotamus, rhinoceros, or tapir refused entry into...

  19. 9 CFR 93.806 - Animals refused entry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Elephants, Hippopotami, Rhinoceroses, and Tapirs § 93.806 Animals refused entry. Any elephant, hippopotamus, rhinoceros, or tapir refused entry into...

  20. 9 CFR 93.806 - Animals refused entry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Elephants, Hippopotami, Rhinoceroses, and Tapirs § 93.806 Animals refused entry. Any elephant, hippopotamus, rhinoceros, or tapir refused entry into...

  1. 9 CFR 93.806 - Animals refused entry.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Elephants, Hippopotami, Rhinoceroses, and Tapirs § 93.806 Animals refused entry. Any elephant, hippopotamus, rhinoceros, or tapir refused entry into...

  2. Address tracing for parallel machines

    NASA Technical Reports Server (NTRS)

    Stunkel, Craig B.; Janssens, Bob; Fuchs, W. Kent

    1991-01-01

    Recently implemented parallel system address-tracing methods based on several metrics are surveyed. The issues specific to collection of traces for both shared and distributed memory parallel computers are highlighted. Five general categories of address-trace collection methods are examined: hardware-captured, interrupt-based, simulation-based, altered microcode-based, and instrumented program-based traces. The problems unique to shared memory and distributed memory multiprocessors are examined separately.

  3. Generic aerocapture atmospheric entry study, volume 1

    NASA Technical Reports Server (NTRS)

    1980-01-01

    An atmospheric entry study to fine a generic aerocapture vehicle capable of missions to Mars, Saturn, and Uranus is reported. A single external geometry was developed through atmospheric entry simulations. Aerocapture is a system design concept which uses an aerodynamically controlled atmospheric entry to provide the necessary velocity depletion to capture payloads into planetary orbit. Design concepts are presented which provide the control accuracy required while giving thermal protection for the mission payload. The system design concepts consist of the following elements: (1) an extendable biconic aerodynamic configuration with lift to drag ratio between 1.0 and 2.0; (2) roll control system concepts to control aerodynamic lift and disturbance torques; (3) aeroshell design concepts capable of meeting dynamic pressure loads during aerocapture; and (4) entry thermal protection system design concepts to meet thermodynamic loads during aerocapture.

  4. Remodeling of Calcium Entry Pathways in Cancer.

    PubMed

    Villalobos, Carlos; Sobradillo, Diego; Hernández-Morales, Miriam; Núñez, Lucía

    2016-01-01

    Ca(2+) entry pathways play important roles in control of many cellular functions, including long-term proliferation, migration and cell death. In recent years, it is becoming increasingly clear that, in some types of tumors, remodeling of Ca(2+) entry pathways could contribute to cancer hallmarks such as excessive proliferation, cell migration and invasion as well as resistance to cell death or survival. In this chapter we briefly review findings related to remodeling of Ca(2+) entry pathways in cancer with emphasis on the mechanisms that contribute to increased store-operated Ca(2+) entry (SOCE) and store-operated currents (SOCs) in colorectal cancer cells. Finally, since SOCE appears critically involved in colon tumorogenesis, the inhibition of SOCE by aspirin and other NSAIDs and its possible contribution to colon cancer chemoprevention is reviewed.

  5. Multiscale perspectives of virus entry via endocytosis.

    PubMed

    Barrow, Eric; Nicola, Anthony V; Liu, Jin

    2013-06-05

    Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strategies. Virus entry via endocytosis is a complex process involving hundreds of cellular proteins. The entire process is dictated by events occurring at multiple time and length scales. In this review, we discuss and evaluate the available means to investigate virus endocytic entry, from both experimental and theoretical/numerical modeling fronts, and highlight the importance of multiscale features. The complexity of the process requires investigations at a systems biology level, which involves the combination of different experimental approaches, the collaboration of experimentalists and theorists across different disciplines, and the development of novel multiscale models.

  6. Aerocapture Inflatable Decelerator for Planetary Entry

    NASA Technical Reports Server (NTRS)

    Reza, Sajjad; Hund, Richard; Kustas, Frank; Willcockson, William; Songer, Jarvis; Brown, Glen

    2007-01-01

    Forward Attached Inflatable Decelerators, more commonly known as inflatable aeroshells, provide an effective, cost efficient means of decelerating spacecrafts by using atmospheric drag for aerocapture or planetary entry instead of conventional liquid propulsion deceleration systems. Entry into planetary atmospheres results in significant heating and aerodynamic pressures which stress aeroshell systems to their useful limits. Incorporation of lightweight inflatable decelerator surfaces with increased surface-area footprints provides the opportunity to reduce heat flux and induced temperatures, while increasing the payload mass fraction. Furthermore, inflatable aeroshell decelerators provide the needed deceleration at considerably higher altitudes and Mach numbers when compared with conventional rigid aeroshell entry systems. Inflatable aeroshells also provide for stowage in a compact space, with subsequent deployment of a large-area, lightweight heatshield to survive entry heating. Use of a deployable heatshield decelerator enables an increase in the spacecraft payload mass fraction and may eliminate the need for a spacecraft backshell.

  7. Entry/Exit Port testing, test report

    SciTech Connect

    Winkelman, R.H.

    1993-05-01

    The Waste Receiving and Processing Module I (WRAP-1) facility must have the ability to allow 55-gallon drums to enter and exit glovebox enclosures. An Entry/Exit Port (Appendix 1, Figure 1), designed by United Engineers and Constructors (UE&C), is one method chosen for drum transfer. The Entry/Exit Port is to be used for entry of 55-gallon drums into both process entry gloveboxes, exit of 55-gallon drum waste pucks from the low-level waste (LLW) glovebox, and loadout of waste from the restricted waste management glovebox. The Entry/Exit Port relies on capture velocity air flow and a neoprene seal to provide alpha confinement when the Port is in the open and closed positions, respectively. Since the glovebox is in a slight vacuum, air flow is directed into the glovebox through the space between the overpack drum and glovebox floor. The air flow is to direct any airborne contamination into the glovebox. A neoprene seal is used to seal the Port door to the glovebox floor, thus maintaining confinement in the closed position. Entry/Exit Port testing took place February 17, 1993, through April 14, 1993, in the 305 building of Westinghouse Hanford Company. Testing was performed in accordance with the Entry/Exit Port Testing Test Plan, document number WHC-SD-WO26-TP-005. A prototype Entry/Exit Port built at the Hanford Site was tested using fluorescent paint pigment and smoke candles as simulant contaminants. This test report is an interim test report. Further developmental testing is required to test modifications made to the Port as the original design of the Port did not provide complete confinement during all stages of operation.

  8. Orion Capsule Handling Qualities for Atmospheric Entry

    NASA Technical Reports Server (NTRS)

    Tigges, Michael A.; Bihari, Brian D.; Stephens, John-Paul; Vos, Gordon A.; Bilimoria, Karl D.; Mueller, Eric R.; Law, Howard G.; Johnson, Wyatt; Bailey, Randall E.; Jackson, Bruce

    2011-01-01

    Two piloted simulations were conducted at NASA's Johnson Space Center using the Cooper-Harper scale to study the handling qualities of the Orion Command Module capsule during atmospheric entry flight. The simulations were conducted using high fidelity 6-DOF simulators for Lunar Return Skip Entry and International Space Station Return Direct Entry flight using bank angle steering commands generated by either the Primary (PredGuid) or Backup (PLM) guidance algorithms. For both evaluations, manual control of bank angle began after descending through Entry Interface into the atmosphere until drogue chutes deployment. Pilots were able to use defined bank management and reversal criteria to accurately track the bank angle commands, and stay within flight performance metrics of landing accuracy, g-loads, and propellant consumption, suggesting that the pilotability of Orion under manual control is both achievable and provides adequate trajectory performance with acceptable levels of pilot effort. Another significant result of these analyses is the applicability of flying a complex entry task under high speed entry flight conditions relevant to the next generation Multi Purpose Crew Vehicle return from Mars and Near Earth Objects.

  9. Hypersonic and planetary entry flight mechanics

    NASA Technical Reports Server (NTRS)

    Vinh, N. X.; Busemann, A.; Culp, R. D.

    1980-01-01

    The book treats hypersonic flight trajectories and atmospheric entry flight mechanics in light of their importance for space shuttle entry. Following a review of the structures of planetary atmospheres and aerodynamic forces, equations are derived for flight over a spherical planet, and the performance of long-range hypervelocity vehicles in extra-atmospheric flight is analyzed. Consideration is then given to vehicle trajectories in the powered and atmospheric reentry phases of flight, and several first-order solutions are derived for various planetary entry situations. The second-order theory of Loh for entry trajectories is presented along with the classical theories of Yaroshevskii and Chapman for entry into planetary atmospheres, and the thermal problems encountered in hypersonic flight are analyzed. A unified theory for entry into planetary atmospheres is then introduced which allows the performance of a general type of lifting vehicle to be studied, and applied to the analysis of orbit contraction due to atmospheric drag, flight with lift modulation and lateral maneuvers.

  10. Models of radon entry: A review

    SciTech Connect

    Gadgil, A.J.

    1991-08-01

    This paper reviews existing models of radon entry into houses. The primary mechanism of radon entry in houses with high indoor concentrations is, in most cases, convective entry of radon bearing soil-gas from the surrounding soil. The driving force for this convective entry is the small indoor-outdoor pressure difference arising from the stack effect and other causes. Entry points for the soil-gas generally are the cracks or gaps in the building substructure, or though other parts of the building shell in direct contact with the soil, although entry may also occur by flow though permeable concrete or cinder block walls of the substructure. Models using analytical solutions to idealized geometrical configurations with simplified boundary conditions obtain analytical tractability of equations to be solved at the cost of severe approximations; their strength is in the insights they offer with their solutions. Models based on lumped parameters attempt to characterize the significant physical behavioral characteristics of the soil-gas and radon flow. When realistic approximations are desired for the boundary conditions and terms in the governing equations, numerical models must be used; these are usually based on finite difference or finite element solutions to the governing equations. Limited data are now available for experimental verification of model predictions. The models are briefly reviewed and their strengths and limitations are discussed.

  11. Trajectory Reconstruction for the Genesis Entry

    NASA Technical Reports Server (NTRS)

    Desai, Prasun N.; Qualls, Garry D.; Schoenenberger, Mark

    2005-01-01

    An overview of the reconstruction analyses performed for the Genesis capsule entry is described. The results indicate that the actual entry prior to the drogue deployment failure was very close to the pre-entry predictions. The capsule landed 8.3 km south of the desired target at Utah Test and Training Range. Analysis on infrared video footage (obtained from the tracking stations) during the descent estimated the onset of the capsule tumble at Mach 0.9. Frequency analysis on the infrared video data indicates that the aerodynamics generated for the Genesis capsule reasonably predicted the drag and static stability. Observations of the heatshield support the pre-entry simulation estimates of a small hypersonic angles-of-attack, since there is very little, if any, charring of the shoulder region or the afterbody. Through this investigation, an overall assertion can be made that all the data gathered from the Genesis entry is consistent with flight performance close to the nominal pre-entry prediction. Consequently, the design principles and methodologies utilized for the flight dynamics, aerodynamics, and aerothermodynamics analyses have been corroborated.

  12. Well engineering for re-entry operations

    SciTech Connect

    1996-10-01

    Oil and gas operators are constantly looking at their existing assets for ways to increase their value. Several operators consider a re-entry program as the principle leveraging technology in strategic acquisitions. Much of the current re-entry operations effort targets the longer reach sidetrack and multilateral well markets. The key to this effort, whether it involves coiled tubing drilling, short radius drilling or multilateral well technologies, is re-entry well engineering. The engineer evaluating a re-entry prospect must apply significant levels of reservoir engineering, rock mechanics, completion engineering and drilling engineering to properly design the well and develop successful procedures. Re-entry drilling means that the operator is working with proven or probable reserves. Completion design and engineering are the most important aspects of well design once the target has been selected. Ultimately, the completion design selected will dictate the type of re-entry program: slot recovery, drilling out below the current casing shoe, or section milling and whipstock sidetracking. It can also dictate the principle aspects of the drilling program. The acceptable wellbore inclination build rates (dogleg severity), wellbore length, and drilling fluid selection are commonly influenced and even dictated by the completion design. These factors are discussed.

  13. Nipah virus entry can occur by macropinocytosis

    SciTech Connect

    Pernet, Olivier; Pohl, Christine; Ainouze, Michelle; Kweder, Hasan; Buckland, Robin

    2009-12-20

    Nipah virus (NiV) is a zoonotic biosafety level 4 paramyxovirus that emerged recently in Asia with high mortality in man. NiV is a member, with Hendra virus (HeV), of the Henipavirus genus in the Paramyxoviridae family. Although NiV entry, like that of other paramyxoviruses, is believed to occur via pH-independent fusion with the host cell's plasma membrane we present evidence that entry can occur by an endocytic pathway. The NiV receptor ephrinB2 has receptor kinase activity and we find that ephrinB2's cytoplasmic domain is required for entry but is dispensable for post-entry viral spread. The mutation of a single tyrosine residue (Y304F) in ephrinB2's cytoplasmic tail abrogates NiV entry. Moreover, our results show that NiV entry is inhibited by constructions and drugs specific for the endocytic pathway of macropinocytosis. Our findings could potentially permit the rapid development of novel low-cost antiviral treatments not only for NiV but also HeV.

  14. Duplication/deletion of chromosome 8p

    SciTech Connect

    Priest, J.H.

    1995-09-11

    The article by Guo et al. provides evidence for deletion of D8S596 loci (assigned to 8p23) in at least some patients with inverted duplications of 8p. Cytogenetic break points forming the inverted duplication are remarkably similar among most of their patients and those reported previously, suggesting a common mechanism for this interesting rearrangement. Why should similar breaks occur in 8p and why is a FISH signal absent in the distal short arm when the ONCOR digoxigenin-labeled probe for loci D8S596 is used? Other studies also indicate that duplication for the region 8p12-p22 is associated with a deletion distal to the duplication itself. 4 refs.

  15. Planetary/DOD entry technology flight experiments. Volume 2: Planetary entry flight experiments

    NASA Technical Reports Server (NTRS)

    Christensen, H. E.; Krieger, R. J.; Mcneilly, W. R.; Vetter, H. C.

    1976-01-01

    The technical feasibility of launching a high speed, earth entry vehicle from the space shuttle to advance technology for the exploration of the outer planets' atmospheres was established. Disciplines of thermodynamics, orbital mechanics, aerodynamics propulsion, structures, design, electronics and system integration focused on the goal of producing outer planet environments on a probe shaped vehicle during an earth entry. Major aspects of analysis and vehicle design studied include: planetary environments, earth entry environment capability, mission maneuvers, capabilities of shuttle upper stages, a comparison of earth entry planetary environments, experiment design and vehicle design.

  16. Genetics Home Reference: 1p36 deletion syndrome

    MedlinePlus

    ... Understand Genetics Home Health Conditions 1p36 deletion syndrome 1p36 deletion syndrome Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description 1p36 deletion syndrome is a disorder that typically causes severe intellectual ...

  17. Characterization of five partial deletions of the factor VIII gene

    SciTech Connect

    Youssoufian, H.; Antonarakis, S.E.; Aronis, S.; Tsiftis, G.; Phillips, D.G.; Kazazian, H.H. Jr.

    1987-06-01

    Hemophilia A is an X-linked disorder of coagulation caused by a deficiency of factor VIII. By using cloned DNA probes, the authors have characterized the following five different partial deletions of the factor VIII gene from a panel of 83 patients with hemophilia A: (i) a 7-kilobase (kb) deletion that eliminates exon 6; (ii) a 2.5-kb deletion that eliminates 5' sequences of exon 14; (iii) a deletion of at least 7 kb that eliminates exons 24 and 25; (iv) a deletion of at least 16 kb that eliminates exons 23-25; and (v) a 5.5-kb deletion that eliminates exon 22. The first four deletions are associated with severe hemophilia A. By contrast, the last deletion is associated with moderate disease, possibly because of in-frame splicing from adjacent exons. None of those patients with partial gene deletions had circulating inhibitors to factor VIII. One deletion occurred de novo in a germ cell of the maternal grandmother, while a second deletion occurred in a germ cell of the maternal grandfather. These observations demonstrate that de novo deletions of X-linked genes can occur in either male or female gametes.

  18. Genetics Home Reference: 22q11.2 deletion syndrome

    MedlinePlus

    ... Home Health Conditions 22q11.2 deletion syndrome 22q11.2 deletion syndrome Enable Javascript to view the expand/ ... Download PDF Open All Close All Description 22q11.2 deletion syndrome (which is also known by several ...

  19. Characterizing Deletion Transformations across Dialects using a Sophisticated Tying Mechanism

    DTIC Science & Technology

    2011-03-30

    suggest nrle candidates for further linguistic studies. Potential appli- cations include forensic phonetics, accent training, and dialect recognition...03-2011 Technical Paper MAR 2011 - APR 2011 Characterizing Deletion Transformations across Dialects using a Sophisticated Tying Mechanism FA8720-05...modeling deletion transformations between dialects . We empirically show that the proposed tying mechanism reduces deletion errors by 33% when compared to a

  20. Immune function in patients with chromosome deletions.

    PubMed Central

    Nurmi, T; Uhari, M; Linna, S L; Silvennoinen-Kassinen, S; Koskela, M; Kiuttu, J; Tiilikainen, A

    1982-01-01

    Non-specific, cell-mediated and humoral immunity were evaluated in six patients with different autosomal deletions, and in two patients with X-chromosome deletions. Six had an increased number of bacterial, viral, and mycotic infections. Mild disturbances were found in the immunological functions of almost every patient. Granulocyte phagocytosis and killing of bacteria were normal in all patients. The chemotactic response was increased in two, and normal in the others. The responses to phytohaemagglutinin and pokeweed mitogen were normal in all patients and the response to concanavalin A was decreased in one patient. The lymphocyte response to purified protein derivative was decreased in the patients as a group when compared to the controls (P less than 0 . 005), but normal to oidiomycin. The number of acid-alpha-naphthyl acetate esterase positive cells was low in four patients. One had a high titre of antinuclear and antithyroid antibodies. One had a low concentration of serum IgA, C3 and C4. One had a high concentration of IgM. Two had elevated levels of C3 and C4. Our results show that several different chromosomal deletions are associated with immunological abnormality. PMID:6979446

  1. Chromosome 11q13 deletion syndrome

    PubMed Central

    Kim, Yu-Seon; Kim, Gun-Ha; Byeon, Jung Hye; Eun, So-Hee

    2016-01-01

    Chromosome 11q13 deletion syndrome has been previously reported as either otodental syndrome or oculo-oto-dental syndrome. The otodental syndrome is characterized by dental abnormalities and high-frequency sensorineural hearing loss, and by ocular coloboma in some cases. The underlying genetic defect causing otodental syndrome is a hemizygous microdeletion involving the FGF3 gene on chromosome 11q13.3. Recently, a new form of severe deafness, microtia (small ear) and small teeth, without the appearance of eye abnormalities, was also reported. In this report, we describe a 1-year-old girl presenting with ptosis of the left upper eyelid, right auricular deformity, high-arched palate, delayed dentition, simian line on the right hand, microcephaly, and developmental delay. In this patient, we identified a deletion in the chromosome 11q13.2-q13.3 (2.75 Mb) region by using an array-comparative genomic hybridization analysis. The deletion in chromosome 11q13 results in a syndrome characterized by variable clinical manifestations. Some of these manifestations involve craniofacial dysmorphology and require a functional workup for hearing, ophthalmic examinations, and long-term dental care. PMID:28018436

  2. 76 FR 2111 - Notice of Receipt of Requests for Amendments to Delete Uses in Certain Pesticide Registrations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ...-5805. FOR FURTHER INFORMATION CONTACT: Christopher Green, Information Technology and Resources...., NW., Washington, DC 20460-0001; telephone number: (703) 347-0367; e-mail address: green.christopher... requests have a 30-day comment period. Table 1--Requests for Amendments to Delete Uses in Certain...

  3. Entry Mechanisms of Herpes Simplex Virus 1 into Murine Epidermis: Involvement of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors

    PubMed Central

    Petermann, Philipp; Thier, Katharina; Rahn, Elena; Rixon, Frazer J.; Bloch, Wilhelm; Özcelik, Semra; Krummenacher, Claude; Barron, Martin J.; Dixon, Michael J.; Scheu, Stefanie; Pfeffer, Klaus

    2014-01-01

    ABSTRACT Skin keratinocytes represent a primary entry site for herpes simplex virus 1 (HSV-1) in vivo. The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) act as efficient receptors for both serotypes of HSV and are sufficient for disease development mediated by HSV-2 in mice. How HSV-1 enters skin and whether both nectin-1 and HVEM are involved are not known. We addressed the impact of nectin-1 during entry of HSV-1 into murine epidermis and investigated the putative contribution of HVEM. Using ex vivo infection of murine epidermis, we showed that HSV-1 entered the basal keratinocytes of the epidermis very efficiently. In nectin-1-deficient epidermis, entry was strongly reduced. Almost no entry was observed, however, in nectin-1-deficient keratinocytes grown in culture. This observation correlated with the presence of HVEM on the keratinocyte surface in epidermis and with the lack of HVEM expression in nectin-1-deficient primary keratinocytes. Our results suggest that nectin-1 is the primary receptor in epidermis, while HVEM has a more limited role. For primary murine keratinocytes, on which nectin-1 acts as a single receptor, electron microscopy suggested that HSV-1 can enter both by direct fusion with the plasma membrane and via endocytic vesicles. Thus, we concluded that nectin-1 directs internalization into keratinocytes via alternative pathways. In summary, HSV-1 entry into epidermis was shown to strongly depend on the presence of nectin-1, but the restricted presence of HVEM can potentially replace nectin-1 as a receptor, illustrating the flexibility employed by HSV-1 to efficiently invade tissue in vivo. IMPORTANCE Herpes simplex virus (HSV) can cause a range of diseases in humans, from uncomplicated mucocutaneous lesions to life-threatening infections. The skin is one target tissue of HSV, and the question of how the virus overcomes the protective skin barrier and penetrates into the tissue to reach its receptors is still open. Previous

  4. 19 CFR 142.44 - Entry number range.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry number range. 142.44 Section 142.44 Customs... (CONTINUED) ENTRY PROCESS Line Release § 142.44 Entry number range. After an application for Line Release has received final approval, filers must provide the port director, in writing, with a range of entry...

  5. 19 CFR 142.44 - Entry number range.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Entry number range. 142.44 Section 142.44 Customs... (CONTINUED) ENTRY PROCESS Line Release § 142.44 Entry number range. After an application for Line Release has received final approval, filers must provide the port director, in writing, with a range of entry...

  6. 19 CFR 142.44 - Entry number range.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Entry number range. 142.44 Section 142.44 Customs... (CONTINUED) ENTRY PROCESS Line Release § 142.44 Entry number range. After an application for Line Release has received final approval, filers must provide the port director, in writing, with a range of entry...

  7. 19 CFR 142.44 - Entry number range.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Entry number range. 142.44 Section 142.44 Customs... (CONTINUED) ENTRY PROCESS Line Release § 142.44 Entry number range. After an application for Line Release has received final approval, filers must provide the port director, in writing, with a range of entry...

  8. 19 CFR 142.44 - Entry number range.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Entry number range. 142.44 Section 142.44 Customs... (CONTINUED) ENTRY PROCESS Line Release § 142.44 Entry number range. After an application for Line Release has received final approval, filers must provide the port director, in writing, with a range of entry...

  9. 7 CFR 319.24-5 - Condition of entry.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Corn Diseases Regulations Governing Entry of Indian Corn Or Maize § 319.24-5 Condition of entry. The corn shall not be removed from the port of entry... Quarantine Programs, that the corn has been properly sterilized and released for entry without...

  10. 7 CFR 319.24-5 - Condition of entry.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Corn Diseases Regulations Governing Entry of Indian Corn Or Maize § 319.24-5 Condition of entry. The corn shall not be removed from the port of entry... Quarantine Programs, that the corn has been properly sterilized and released for entry without...

  11. 7 CFR 319.24-5 - Condition of entry.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Corn Diseases Regulations Governing Entry of Indian Corn Or Maize § 319.24-5 Condition of entry. The corn shall not be removed from the port of entry... Quarantine Programs, that the corn has been properly sterilized and released for entry without...

  12. 7 CFR 319.24-5 - Condition of entry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Corn Diseases Regulations Governing Entry of Indian Corn Or Maize § 319.24-5 Condition of entry. The corn shall not be removed from the port of entry... Quarantine Programs, that the corn has been properly sterilized and released for entry without...

  13. 7 CFR 319.24-5 - Condition of entry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Corn Diseases Regulations Governing Entry of Indian Corn Or Maize § 319.24-5 Condition of entry. The corn shall not be removed from the port of entry... Quarantine Programs, that the corn has been properly sterilized and released for entry without...

  14. 7 CFR 319.8-26 - Material refused entry.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., or other expenses incidental to the safeguarding or disposal of material refused entry by the... 7 Agriculture 5 2014-01-01 2014-01-01 false Material refused entry. 319.8-26 Section 319.8-26... Provisions § 319.8-26 Material refused entry. Any material refused entry for noncompliance with...

  15. 7 CFR 319.8-26 - Material refused entry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., or other expenses incidental to the safeguarding or disposal of material refused entry by the... 7 Agriculture 5 2011-01-01 2011-01-01 false Material refused entry. 319.8-26 Section 319.8-26... Provisions § 319.8-26 Material refused entry. Any material refused entry for noncompliance with...

  16. 7 CFR 319.8-26 - Material refused entry.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., or other expenses incidental to the safeguarding or disposal of material refused entry by the... 7 Agriculture 5 2012-01-01 2012-01-01 false Material refused entry. 319.8-26 Section 319.8-26... Provisions § 319.8-26 Material refused entry. Any material refused entry for noncompliance with...

  17. 7 CFR 319.8-26 - Material refused entry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., or other expenses incidental to the safeguarding or disposal of material refused entry by the... 7 Agriculture 5 2010-01-01 2010-01-01 false Material refused entry. 319.8-26 Section 319.8-26... Provisions § 319.8-26 Material refused entry. Any material refused entry for noncompliance with...

  18. 48 CFR 52.225-8 - Duty-Free Entry.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Duty-Free Entry. 52.225-8...-Free Entry. As prescribed in 25.1101(e), insert the following clause: Duty-Free Entry (OCT 2010) (a... accorded duty-free entry. (c) Except as provided in paragraph (d) of this clause or elsewhere in...

  19. 48 CFR 52.225-8 - Duty-Free Entry.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Duty-Free Entry. 52.225-8...-Free Entry. As prescribed in 25.1101(e), insert the following clause: Duty-Free Entry (OCT 2010) (a... accorded duty-free entry. (c) Except as provided in paragraph (d) of this clause or elsewhere in...

  20. 48 CFR 52.225-8 - Duty-Free Entry.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Duty-Free Entry. 52.225-8...-Free Entry. As prescribed in 25.1101(e), insert the following clause: Duty-Free Entry (OCT 2010) (a... accorded duty-free entry. (c) Except as provided in paragraph (d) of this clause or elsewhere in...

  1. 48 CFR 52.225-8 - Duty-Free Entry.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Duty-Free Entry. 52.225-8...-Free Entry. As prescribed in 25.1101(e), insert the following clause: Duty-Free Entry (OCT 2010) (a... accorded duty-free entry. (c) Except as provided in paragraph (d) of this clause or elsewhere in...

  2. 7 CFR 319.8-26 - Material refused entry.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., or other expenses incidental to the safeguarding or disposal of material refused entry by the... 7 Agriculture 5 2013-01-01 2013-01-01 false Material refused entry. 319.8-26 Section 319.8-26... Provisions § 319.8-26 Material refused entry. Any material refused entry for noncompliance with...

  3. Molecular refinement of the 1p36 deletion syndrome reveals size diversity and a preponderance of maternally derived deletions.

    PubMed

    Wu, Y Q; Heilstedt, H A; Bedell, J A; May, K M; Starkey, D E; McPherson, J D; Shapira, S K; Shaffer, L G

    1999-02-01

    The deletion of chromosome 1p36 is a newly recognized, relatively common contiguous gene deletion syndrome with a variable phenotype. The clinical features have recently been delineated and molecular analysis indicates that the prevalence of certain phenotypic features appears to correlate with deletion size. Phenotype/genotype comparisons have allowed the assignment of certain clinical features to specific deletion intervals, significantly narrowing the regions within which to search for candidate genes. We have extensively characterized the deletion regions in 30 cases using microsatellite markers and fluorescence in situ hybridization analyses. The map order of 28 microsatellite markers spanning the deletion region was obtained by a combination of genotypic analysis and physical mapping. The deletion region was divided into six intervals and breakpoints were found to cluster in mainly two regions. Molecular analysis of the deletions showed that two patients had complex re-arrangements; these cases shared their distal and proximal breakpoints in the two common breakpoint regions. Of the de novo deletions ( n = 28) in whichparental samples were available and the analysis was informative ( n = 27), there were significantly morematernally derived deletions ( n = 21) than paternally derived deletions ( n = 6) (chi1(2) = 8.35, P < 0.0001). Phenotype/genotype correlations and refinements of critical regions in our naturally occurring deletion panel have delineated specific areas in which to focus the search for the causative genes for the features of this syndrome.

  4. Every Other Day. Keynote Address.

    ERIC Educational Resources Information Center

    Tiller, Tom

    Schools need to be reoriented and restructured so that what is taught and learned, and the way in which it is taught and learned, are better integrated with young people's real-world experiences. Many indicators suggest that the meaningful aspects of school have been lost in the encounter with modern times. The title of this address--"Every…

  5. Agenda to address climate change

    SciTech Connect

    1998-10-01

    This document looks at addressing climate change in the 21st century. Topics covered are: Responding to climate change; exploring new avenues in energy efficiency; energy efficiency and alternative energy; residential sector; commercial sector; industrial sector; transportation sector; communities; renewable energy; understanding forests to mitigate and adapt to climate change; the Forest Carbon budget; mitigation and adaptation.

  6. Addressing Phonological Questions with Ultrasound

    ERIC Educational Resources Information Center

    Davidson, Lisa

    2005-01-01

    Ultrasound can be used to address unresolved questions in phonological theory. To date, some studies have shown that results from ultrasound imaging can shed light on how differences in phonological elements are implemented. Phenomena that have been investigated include transitional schwa, vowel coalescence, and transparent vowels. A study of…

  7. Keynote Address: Rev. Mark Massa

    ERIC Educational Resources Information Center

    Massa, Mark S.

    2011-01-01

    Rev. Mark S. Massa, S.J., is the dean and professor of Church history at the School of Theology and Ministry at Boston College. He was invited to give a keynote to begin the third Catholic Higher Education Collaborative Conference (CHEC), cosponsored by Boston College and Fordham University. Fr. Massa's address posed critical questions about…

  8. State of the Lab Address

    ScienceCinema

    King, Alex

    2016-07-12

    In his third-annual State of the Lab address, Ames Laboratory Director Alex King called the past year one of "quiet but strong progress" and called for Ames Laboratory to continue to build on its strengths while responding to changing expectations for energy research.

  9. Research strategies for addressing uncertainties

    USGS Publications Warehouse

    Busch, David E.; Brekke, Levi D.; Averyt, Kristen; Jardine, Angela; Welling, Leigh; Garfin, Gregg; Jardine, Angela; Merideth, Robert; Black, Mary; LeRoy, Sarah

    2013-01-01

    Research Strategies for Addressing Uncertainties builds on descriptions of research needs presented elsewhere in the book; describes current research efforts and the challenges and opportunities to reduce the uncertainties of climate change; explores ways to improve the understanding of changes in climate and hydrology; and emphasizes the use of research to inform decision making.

  10. Command generator tracker based direct model reference adaptive tracking guidance for Mars atmospheric entry

    NASA Astrophysics Data System (ADS)

    Li, Shuang; Peng, Yuming

    2012-01-01

    In order to accurately deliver an entry vehicle through the Martian atmosphere to the prescribed parachute deployment point, active Mars entry guidance is essential. This paper addresses the issue of Mars atmospheric entry guidance using the command generator tracker (CGT) based direct model reference adaptive control to reduce the adverse effect of the bounded uncertainties on atmospheric density and aerodynamic coefficients. Firstly, the nominal drag acceleration profile meeting a variety of constraints is planned off-line in the longitudinal plane as the reference model to track. Then, the CGT based direct model reference adaptive controller and the feed-forward compensator are designed to robustly track the aforementioned reference drag acceleration profile and to effectively reduce the downrange error. Afterwards, the heading alignment logic is adopted in the lateral plane to reduce the crossrange error. Finally, the validity of the guidance algorithm proposed in this paper is confirmed by Monte Carlo simulation analysis.

  11. High proportion of 22q13 deletions and SHANK3 mutations in Chinese patients with intellectual disability.

    PubMed

    Gong, Xiaohong; Jiang, Yu-Wu; Zhang, Xin; An, Yu; Zhang, Jun; Wu, Ye; Wang, Jingmin; Sun, Yangfei; Liu, Yanyan; Gao, Xuewu; Shen, Yiping; Wu, Xiru; Qiu, Zilong; Jin, Li; Wu, Bai-Lin; Wang, Hongyan

    2012-01-01

    Intellectual disability (ID) is a heterogeneous disorder caused by chromosomal abnormalities, monogenic factors and environmental factors. 22q13 deletion syndrome is a genetic disorder characterized by severe ID. Although the frequency of 22q13 deletions in ID is unclear, it is believed to be largely underestimated. To address this issue, we used Affymetrix Human SNP 6.0 array to detect the 22q13 deletions in 234 Chinese unexplained ID patients and 103 controls. After the Quality Control (QC) test of raw data, 22q13 deletions were found in four out of 230 cases (1.7%), while absent in parents of the cases and 101 controls. A review of genome-wide microarray studies in ID was performed and the frequency of 22q13 deletions from the literatures was 0.24%, much lower than our report. The overlapping region shared by all 4 cases encompasses the gene SHANK3. A heterozygous de novo nonsense mutation Y1015X of SHANK3 was identified in one ID patient. Cortical neurons were prepared from embryonic mice and were transfected with a control plasmid, shank3 wild-type (WT) or mutant plasmids. Overexpression of the Y1015 mutant in neurons significantly affected neurite outgrowth compared with shank3 WT. These findings suggest that 22q13 deletions may be a more frequent cause for Chinese ID patients than previously thought, and the SHANK3 gene is involved in the neurite development.

  12. Lowering Entry Barriers for Multidisciplinary Cyber(e)-Infrastructures

    NASA Astrophysics Data System (ADS)

    Nativi, S.

    2012-04-01

    Multidisciplinarity is more and more important to study the Earth System and address Global Changes. To achieve that, multidisciplinary cyber(e)-infrastructures are an important instrument. In the last years, several European, US and international initiatives have been started to carry out multidisciplinary infrastructures, including: the Spatial Information in the European Community (INSPIRE), the Global Monitoring for Environment and Security (GMES), the Data Observation Network for Earth (DataOne), and the Global Earth Observation System of Systems (GEOSS). The majority of these initiatives are developing service-based digital infrastructures asking scientific Communities (i.e. disciplinary Users and data Producers) to implement a set of standards for information interoperability. For scientific Communities, this has represented an entry barrier which has proved to be high, in several cases. In fact, both data Producers and Users do not seem to be willing to invest precious resources to become expert on interoperability solutions -on the contrary, they are focused on developing disciplinary and thematic capacities. Therefore, an important research topic is lowering entry barriers for joining multidisciplinary cyber(e)-Infrastructures. This presentation will introduce a new approach to achieve multidisciplinary interoperability underpinning multidisciplinary infrastructures and lowering the present entry barriers for both Users and data Producers. This is called the Brokering approach: it extends the service-based paradigm by introducing a new a Brokering layer or cloud which is in charge of managing all the interoperability complexity (e.g. data discovery, access, and use) thus easing Users' and Producers' burden. This approach was successfully experimented in the framework of several European FP7 Projects and in GEOSS.

  13. Mars 2020 Entry, Descent and Landing Instrumentation (MEDLI2)

    NASA Technical Reports Server (NTRS)

    Bose, Deepak; Wright, Henry; White, Todd; Schoenenberger, Mark; Santos, Jose; Karlgaard, Chris; Kuhl, Chris; Oishi, TOmo; Trombetta, Dominic

    2016-01-01

    This paper will introduce Mars Entry Descent and Landing Instrumentation (MEDLI2) on NASA's Mars2020 mission. Mars2020 is a flagship NASA mission with science and technology objectives to help answer questions about possibility of life on Mars as well as to demonstrate technologies for future human expedition. Mars2020 is scheduled for launch in 2020. MEDLI2 is a suite of instruments embedded in the heatshield and backshell thermal protection systems of Mars2020 entry vehicle. The objectives of MEDLI2 are to gather critical aerodynamics, aerothermodynamics and TPS performance data during EDL phase of the mission. MEDLI2 builds up the success of MEDLI flight instrumentation on Mars Science Laboratory mission in 2012. MEDLI instrumentation suite measured surface pressure and TPS temperature on the heatshield during MSL entry into Mars. MEDLI data has since been used for unprecedented reconstruction of aerodynamic drag, vehicle attitude, in-situ atmospheric density, aerothermal heating, transition to turbulence, in-depth TPS performance and TPS ablation. [1,2] In addition to validating predictive models, MEDLI data has highlighted extra margin available in the MSL forebody TPS, which can potentially be used to reduce vehicle parasitic mass. MEDLI2 expands the scope of instrumentation by focusing on quantities of interest not addressed in MEDLI suite. The type the sensors are expanded and their layout on the TPS modified to meet these new objectives. The paper will provide key motivation and governing requirements that drive the choice and the implementation of the new sensor suite. The implementation considerations of sensor selection, qualification, and demonstration of minimal risk to the host mission will be described. The additional challenges associated with mechanical accommodation, electrical impact, data storage and retrieval for MEDLI2 system, which extends sensors to backshell will also be described.

  14. Entry Year Pilot Project: A Reflective Approach to Mentoring Ohio's Entry Year Teachers.

    ERIC Educational Resources Information Center

    Murray, Susan R.; Hillkirk, Keith

    This monograph describes Ohio University College of Education's Entry Year Pilot Project. The College of Education was awarded grant money to create and implement a mentoring program to help entry-year teachers through their first year and through the Praxis III assessment. The project involved beginning teachers, school-level mentors, and…

  15. 76 FR 66875 - Informal Entry Limit and Removal of a Formal Entry Requirement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... reduced the value of that amount in real terms. Consequently, CBP proposes to raise the current informal... reduce the administrative burden on importers and other entry filers. Moreover, CBP proposes to remove... proposed change will reduce the overall administrative burden on importers and ] other entry filers...

  16. Atmospheric Entry Studies for Venus Missions: 45 Sphere-Cone Rigid Aeroshells and Ballistic Entries

    NASA Technical Reports Server (NTRS)

    Prabhu, Dinesh K.; Spilker, Thomas R.; Allen, Gary A., Jr.; Hwang, Helen H.; Cappuccio, Gelsomina; Moses, Robert W.

    2013-01-01

    The present study considers direct ballistic entries into the atmosphere of Venus using a 45deg sphere-cone rigid aeroshell, a legacy shape that has been used successfully in the past in the Pioneer Venus Multiprobe Mission. For a number of entry mass and heatshield diameter combinations (i.e., various ballistic coefficients) and entry velocities, the trajectory space in terms of entry flight path angles between skip out and -30deg is explored with a 3DoF trajectory code, TRAJ. From these trajectories, the viable entry flight path angle space is determined through the use of mechanical and thermal performance limits on the thermal protection material and science payload; the thermal protection material of choice is entry-grade carbon phenolic, for which a material thermal response model is available. For mechanical performance, a 200 g limit is placed on the peak deceleration load experienced by the science instruments, and 10 bar is assumed as the pressure limit for entry-grade carbon-phenolic material. For thermal performance, inflection points in the total heat load distribution are used as cut off criteria. Analysis of the results shows the existence of a range of critical ballistic coefficients beyond which the steepest possible entries are determined by the pressure limit of the material rather than the deceleration load limit.

  17. Effect of Cognitive Entry Behaviors and Affective Entry Characteristics on Learning Level

    ERIC Educational Resources Information Center

    Çaliskan, Muhittin

    2014-01-01

    In this study, the effect of cognitive entry behaviors and affective entry characteristics on learning level was investigated. The study was conducted on 258 first year students attending the Faculty of Education in the autumn semester of the 2011-2012 academic year. The study was conducted using the relational survey model and data was collected…

  18. Thermal Analysis Methods For Earth Entry Vehicle

    NASA Technical Reports Server (NTRS)

    Amundsen, Ruth M.; Dec, John A.; Lindell, Michael C.

    2000-01-01

    Thermal analysis of a vehicle designed to return samples from another planet, such as the Earth Entry vehicle for the Mars Sample Return mission, presents several unique challenges. The Earth Entry Vehicle (EEV) must contain Martian material samples after they have been collected and protect them from the high heating rates of entry into the Earth's atmosphere. This requirement necessitates inclusion of detailed thermal analysis early in the design of the vehicle. This paper will describe the challenges and solutions for a preliminary thermal analysis of an Earth Entry Vehicle. The aeroheating on the vehicle during entry would be the main driver for the thermal behavior, and is a complex function of time, spatial position on the vehicle, vehicle temperature, and trajectory parameters. Thus, the thermal analysis must be closely tied to the aeroheating analysis in order to make accurate predictions. Also, the thermal analysis must account for the material response of the ablative thermal protection system (TPS). For the exo-atmospheric portion of the mission, the thermal analysis must include the orbital radiation fluxes on the surfaces. The thermal behavior must also be used to predict the structural response of the vehicle (the thermal stress and strains) and whether they remain within the capability of the materials. Thus, the thermal analysis requires ties to the three-dimensional geometry, the aeroheating analysis, the material response analysis, the orbital analysis, and the structural analysis. The goal of this paper is to describe to what degree that has been achieved.

  19. Feasibility study of low angle planetary entry. [probe design for Jovian entry

    NASA Technical Reports Server (NTRS)

    Defrees, R. E.

    1975-01-01

    The feasibility of a Jovian entry by a probe originally designed for Saturn and Uranus entries is examined. An entry probe is described which is capable of release near an outer planet's sphere of influence and descent to a predetermined target entry point in the planet's atmosphere. The probe is designed so as to survive the trapped particle radiation belts and an entry heating pulse. Data is gathered and relayed to an overflying spacecraft bus during descent. Probe variations for two similar missions are described. In the first flyby of Jupiter by a Pioneer spacecraft launched during the 1979 opportunity is examined parametrically. In the second mission an orbiter based on Pioneer and launched in 1980 is defined in specific terms. The differences rest in the science payloads and directly affected wiring and electronics packages.

  20. MCC level C formulation requirements. Entry guidance and entry autopilot, optional TAEM targeting

    NASA Technical Reports Server (NTRS)

    Harpold, J. C.

    1980-01-01

    The level C software formulations requirements for the entry guidance and the simplified autopilot to be used by the Mission Control Center (MCC) entry processor are presented. The modifications required to functionally simulate optional Terminal Area Energy Management (TAEM) targeting capability (OTT) are incorporated. Implementation of this logic in the MCC must be coordinated with flight software OTT implementation and MCC TAEM guidance OTT. The entry guidance logic is based on the orbiter avionics entry guidance software. Descriptions of the entry guidance detailed formulation requirements, the detailed autopilot formulation requirements, and the targeting routine are given. Also included are a definition of coordinate systems, a list of parameter definitions for the software formulations, and a set of formulation flow charts.

  1. Shuttle program. MCC Level C formulation requirements: Entry guidance and entry autopilot

    NASA Technical Reports Server (NTRS)

    Harpold, J. C.; Hill, O.

    1980-01-01

    A set of preliminary entry guidance and autopilot software formulations is presented for use in the Mission Control Center (MCC) entry processor. These software formulations meet all level B requirements. Revision 2 incorporates the modifications required to functionally simulate optimal TAEM targeting capability (OTT). Implementation of this logic in the MCC must be coordinated with flight software OTT implementation and MCC TAEM guidance OTT. The entry guidance logic is based on the Orbiter avionics entry guidance software. This MCC requirements document contains a definition of coordinate systems, a list of parameter definitions for the software formulations, a description of the entry guidance detailed formulation requirements, a description of the detailed autopilot formulation requirements, a description of the targeting routine, and a set of formulation flow charts.

  2. Evaluation of Mars Entry Reconstructured Trajectories Based on Hypothetical 'Quick-Look' Entry Navigation Data

    NASA Technical Reports Server (NTRS)

    Pastor, P. Rick; Bishop, Robert H.; Striepe, Scott A.

    2000-01-01

    A first order simulation analysis of the navigation accuracy expected from various Navigation Quick-Look data sets is performed. Here quick-look navigation data are observations obtained by hypothetical telemetried data transmitted on the fly during a Mars probe's atmospheric entry. In this simulation study, navigation data consists of 3-axis accelerometer sensor and attitude information data. Three entry vehicle guidance types are studied: I. a Maneuvering entry vehicle (as with Mars 01 guidance where angle of attack and bank angle are controlled); II. Zero angle-of-attack controlled entry vehicle (as with Mars 98); and III. Ballistic, or spin stabilized entry vehicle (as with Mars Pathfinder);. For each type, sensitivity to progressively under sampled navigation data and inclusion of sensor errors are characterized. Attempts to mitigate the reconstructed trajectory errors, including smoothing, interpolation and changing integrator characteristics are also studied.

  3. PE_PGRS33 Contributes to Mycobacterium tuberculosis Entry in Macrophages through Interaction with TLR2.

    PubMed

    Palucci, Ivana; Camassa, Serena; Cascioferro, Alessandro; Sali, Michela; Anoosheh, Saber; Zumbo, Antonella; Minerva, Mariachiara; Iantomasi, Raffaella; De Maio, Flavio; Di Sante, Gabriele; Ria, Francesco; Sanguinetti, Maurizio; Palù, Giorgio; Brennan, Michael J; Manganelli, Riccardo; Delogu, Giovanni

    2016-01-01

    PE_PGRS represent a large family of proteins typical of pathogenic mycobacteria whose members are characterized by an N-terminal PE domain followed by a large Gly-Ala repeat-rich C-terminal domain. Despite the abundance of PE_PGRS-coding genes in the Mycobacterium tuberculosis (Mtb) genome their role and function in the biology and pathogenesis still remains elusive. In this study, we generated and characterized an Mtb H37Rv mutant (MtbΔ33) in which the structural gene of PE_PGRS33, a prototypical member of the protein family, was inactivated. We showed that this mutant entered macrophages with an efficiency up to ten times lower than parental or complemented strains, while its efficiency in infecting pneumocytes remained unaffected. Interestingly, the lack of PE_PGRS33 did not affect the intracellular growth of this mutant in macrophages. Using a series of functional deletion mutants of the PE_PGRS33 gene to complement the MtbΔ33 strain, we demonstrated that the PGRS domain is required to mediate cell entry into macrophages, with the key domain encompassing position 140-260 amino acids of PE_PGRS33. PE_PGRS33-mediated entry into macrophages was abolished in TLR2-deficient mice, as well as following treatment with wortmannin or an antibody against the complement receptor 3 (CR3), indicating that PE_PGRS33-mediated entry of Mtb in macrophages occurs through interaction with TLR2.

  4. Glycoprotein D actively induces rapid internalization of two nectin-1 isoforms during herpes simplex virus entry

    SciTech Connect

    Stiles, Katie M.; Krummenacher, Claude

    2010-03-30

    Entry of herpes simplex virus (HSV) occurs either by fusion at the plasma membrane or by endocytosis and fusion with an endosome. Binding of glycoprotein D (gD) to a receptor such as nectin-1 is essential in both cases. We show that virion gD triggered the rapid down-regulation of nectin-1 with kinetics similar to those of virus entry. In contrast, nectin-1 was not constitutively recycled from the surface of uninfected cells. Both the nectin-1alpha and beta isoforms were internalized in response to gD despite having different cytoplasmic tails. However, deletion of the nectin-1 cytoplasmic tail slowed down-regulation of nectin-1 and internalization of virions. These data suggest that nectin-1 interaction with a cytoplasmic protein is not required for its down-regulation. Overall, this study shows that gD binding actively induces the rapid internalization of various forms of nectin-1. We suggest that HSV activates a nectin-1 internalization pathway to use for endocytic entry.

  5. Atomic clusters with addressable complexity

    NASA Astrophysics Data System (ADS)

    Wales, David J.

    2017-02-01

    A general formulation for constructing addressable atomic clusters is introduced, based on one or more reference structures. By modifying the well depths in a given interatomic potential in favour of nearest-neighbour interactions that are defined in the reference(s), the potential energy landscape can be biased to make a particular permutational isomer the global minimum. The magnitude of the bias changes the resulting potential energy landscape systematically, providing a framework to produce clusters that should self-organise efficiently into the target structure. These features are illustrated for small systems, where all the relevant local minima and transition states can be identified, and for the low-energy regions of the landscape for larger clusters. For a 55-particle cluster, it is possible to design a target structure from a transition state of the original potential and to retain this structure in a doubly addressable landscape. Disconnectivity graphs based on local minima that have no direct connections to a lower minimum provide a helpful way to visualise the larger databases. These minima correspond to the termini of monotonic sequences, which always proceed downhill in terms of potential energy, and we identify them as a class of biminimum. Multiple copies of the target cluster are treated by adding a repulsive term between particles with the same address to maintain distinguishable targets upon aggregation. By tuning the magnitude of this term, it is possible to create assemblies of the target cluster corresponding to a variety of structures, including rings and chains.

  6. Woven Thermal Protection System Based Heat-shield for Extreme Entry Environments Technology (HEEET)

    NASA Technical Reports Server (NTRS)

    Chinnapongse, Ronald; Ellerbe, Donald; Stackpoole, Maragaret; Venkatapathy, Ethiraj; Beerman, Adam; Feldman, Jay; Peterson Keith; Prabhu, Dinesh; Dillman, Robert; Munk, Michelle

    2013-01-01

    NASA's future robotic missions utilizing an entry system into Venus and the outer planets, namely, Saturn, Uranus, Neptune, result in extremely severe entry conditions that exceed the capabilities of state of the art low to mid density ablators such as PICA or Avcoat. Therefore mission planners typically assume the use of a fully dense carbon phenolic heat shield similar to what was flown on Pioneer Venus and Galileo. Carbon phenolic (CP) is a robust TPS material however its high density and relatively high thermal conductivity constrain mission planners to steep entries, with high heat fluxes and pressures and short entry durations, in order for CP to be feasible from a mass perspective. The high entry conditions pose challenges for certification in existing ground based test facilities and the longer-­-term sustainability of CP will continue to pose challenges. In 2012 the Game Changing Development Program (GCDP) in NASA's Space Technology Mission Directorate funded NASA ARC to investigate the feasibility of a Woven Thermal Protection System (WTPS) to meet the needs of NASA's most challenging entry missions. This project was highly successful demonstrating that a Woven TPS solution compares favorably to CP in performance in simulated reentry environments and provides the opportunity to manufacture graded materials that should result in overall reduced mass solutions and enable a much broader set of missions than does CP. Building off the success of the WTPS project GCDP has funded a follow on project to further mature and scale up the WTPS concept for insertion into future NASA robotic missions. The matured WTPS will address the CP concerns associated with ground based test limitations and sustainability. This presentation will briefly discuss results from the WTPS Project and the plans for WTPS maturation into a heat-­-shield for extreme entry environment.

  7. Woven Thermal Protection System Based Heat-shield for Extreme Entry Environments Technology (HEEET)

    NASA Technical Reports Server (NTRS)

    Ellerby, Donald; Venkatapathy, Ethiraj; Stackpoole, Margaret; Chinnapongse, Ronald; Munk, Michelle; Dillman, Robert; Feldman, Jay; Prabhu, Dinesh; Beerman, Adam

    2013-01-01

    NASA's future robotic missions utilizing an entry system into Venus and the outer planets, namely, Saturn, Uranus, Neptune, result in extremely high entry conditions that exceed the capabilities of state of the art low to mid density ablators such as PICA or Avcoat. Therefore mission planners typically assume the use of a fully dense carbon phenolic heat shield similar to what was flown on Pioneer Venus and Galileo. Carbon phenolic is a robust TPS material however its high density and relatively high thermal conductivity constrain mission planners to steep entries, with high heat fluxes and pressures and short entry durations, in order for CP to be feasible from a mass perspective. The high entry conditions pose challenges for certification in existing ground based test facilities and the longer-term sustainability of CP will continue to pose challenges. In 2012 the Game Changing Development Program (GCDP) in NASA's Space Technology Mission Directorate funded NASA ARC to investigate the feasibility of a Woven Thermal Protection System (WTPS) to meet the needs of NASA's most challenging entry missions. This project was highly successful demonstrating that a Woven TPS solution compares favorably to CP in performance in simulated reentry environments and provides the opportunity to manufacture graded materials that should result in overall reduced mass solutions and enable a much broader set of missions than does CP. Building off the success of the WTPS project GCDP has funded a follow on project to further mature and scale up the WTPS concept for insertion into future NASA robotic missions. The matured WTPS will address the CP concerns associated with ground based test limitations and sustainability. This presentation will briefly discuss results from the WTPS Project and the plans for WTPS maturation into a heat-shield for extreme entry environment.

  8. Public university entry in Ghana: Is it equitable?

    NASA Astrophysics Data System (ADS)

    Yusif, Hadrat; Yussof, Ishak; Osman, Zulkifly

    2013-06-01

    Public universities in Ghana are highly subsidised by the central government and account for about 80 per cent of university students in the country. Yet issues of fairness in terms of entry into the public university system have so far hardly been addressed. To find out whether participation in public university education is equitable, the authors of this paper carried out a binary logistic regression analysis. Individual data were collected from 1,129 (614 male and 515 female) final year senior high school (SHS) students for the 2009 cohort. The authors measured student, father and mother characteristics likely to influence admission to a public university. The results show that the major predictors of public university entry are students' academic ability, quality of SHS attended and number of siblings. This seems to suggest that there is a significant bias in the selection of students from different socio-economic groups for admission to highly subsidised public universities. The implication is that public financing of university education in Ghana may not be equitable.

  9. Submicroscopic deletions at 22q11.2: Variability of the clinical picture and delineation of a commonly deleted region

    SciTech Connect

    Lindsay, E.A.; Shaffer, L.G.; Greenberg, F.

    1995-03-27

    DiGeorge anomaly (DGA) and velo-cardio-facial syndrome (VCFS) are frequently associated with monosomy of chromosome region 22q11. Most patients have a submicroscopic deletion, recently estimated to be at least 1-2 Mb. It is not clear whether individuals who present with only some of the features of these conditions have the deletion, and if so, whether the size of the deletion varies from those with more classic phenotypes. We have used fluorescence in situ hybridization (FISH) to assess the deletion status of 85 individuals referred to us for molecular analysis, with a wide range of DGA-like or VCFS-like clinical features. The test probe used was the cosmid sc11.1, which detects two loci about 2 Mb apart in 22q11.2. Twenty-four patients carried the deletion. Of the deleted patients, most had classic DGA or VCFS phenotypes, but 6 deleted patients had mild phenotypes, including 2 with minor facial anomalies and velopharyngeal incompetence as the only presenting signs. Despite the great phenotypic variability among the deleted patients, none had a deletion smaller than the 2-Mb region defined by sc11.1. Smaller deletions were not detected in patients with particularly suggestive phenotypes who were not deleted for sc11.1, even when tested with two other probes from the DGA/VCFS region. 24 refs., 2 figs., 2 tabs.

  10. Challenges to Computational Aerothermodynamic Simulation and Validation for Planetary Entry Vehicle Analysis

    NASA Technical Reports Server (NTRS)

    Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, Bil

    2010-01-01

    Challenges to computational aerothermodynamic (CA) simulation and validation of hypersonic flow over planetary entry vehicles are discussed. Entry, descent, and landing (EDL) of high mass to Mars is a significant driver of new simulation requirements. These requirements include simulation of large deployable, flexible structures and interactions with reaction control system (RCS) and retro-thruster jets. Simulation of radiation and ablation coupled to the flow solver continues to be a high priority for planetary entry analyses, especially for return to Earth and outer planet missions. Three research areas addressing these challenges are emphasized. The first addresses the need to obtain accurate heating on unstructured tetrahedral grid systems to take advantage of flexibility in grid generation and grid adaptation. A multi-dimensional inviscid flux reconstruction algorithm is defined that is oriented with local flow topology as opposed to grid. The second addresses coupling of radiation and ablation to the hypersonic flow solver - flight- and ground-based data are used to provide limited validation of these multi-physics simulations. The third addresses the challenges of retro-propulsion simulation and the criticality of grid adaptation in this application. The evolution of CA to become a tool for innovation of EDL systems requires a successful resolution of these challenges.

  11. Challenges to Computational Aerothermodynamic Simulation and Validation for Planetary Entry Vehicle Analysis

    NASA Technical Reports Server (NTRS)

    Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, Bil

    2010-01-01

    Challenges to computational aerothermodynamic (CA) simulation and validation of hypersonic flow over planetary entry vehicles are discussed. Entry, descent, and landing (EDL) of high mass to Mars is a significant driver of new simulation requirements. These requirements include simulation of large deployable, flexible structures and interactions with reaction control system (RCS) and retro-thruster jets. Simulation of radiation and ablation coupled to the flow solver continues to be a high priority for planetary entry analyses, especially for return to Earth and outer planet missions. Three research areas addressing these challenges are emphasized. The first addresses the need to obtain accurate heating on unstructured tetrahedral grid systems to take advantage of flexibility in grid generation and grid adaptation. A multi-dimensional inviscid flux reconstruction algorithm is defined that is oriented with local flow topology as opposed to grid. The second addresses coupling of radiation and ablation to the hypersonic flow solver--flight- and ground-based data are used to provide limited validation of these multi-physics simulations. The third addresses the challenges of retro-propulsion simulation and the criticality of grid adaptation in this application. The evolution of CA to become a tool for innovation of EDL systems requires a successful resolution of these challenges.

  12. Cubesat Application for Planetary Entry Missions (CAPE)

    NASA Technical Reports Server (NTRS)

    Esper, Jaime; Baumann, Jean-Pierre; Herdrich, Georg

    2013-01-01

    The Cubesat Application for Planetary Entry Missions (CAPE) concept describes a high-performing Cubesat system which includes a propulsion module and miniaturized technologies capable of surviving atmospheric entry heating, while reliably transmitting scientific and engineering data. The Micro Return Capsule 2 (MIRKA2) is CAPE’s first planetary entry probe flight prototype. Within this context, this paper summarizes CAPE’s configuration and typical operational scenario. It also summarizes MIRKA2’s design and basic aerodynamic characteristics, and discusses potential challenges drawn from the experience of missions such as Stardust and MUSES-C. CAPE not only opens the door to new planetary mission capabilities, it also offers relatively low-cost opportunities especially suitable to university participation.

  13. Earth Entry Vehicle for Mars Sample Return

    NASA Technical Reports Server (NTRS)

    Mitcheltree, R. A.; Braun, R. D.; Hughes. S. J.; Simonsen, L. C.

    2000-01-01

    The driving requirement for design of a Mars Sample return mission is assuring containment of the returned samples. The impact of this requirement on developmental costs, mass allocation, and design approach of the Earth Entry Vehicle is significant. A simple Earth entry vehicle is described which can meet these requirements and safely transport the Mars Sample Return mission's sample through the Earth's atmosphere to a recoverable location on the surface. Detailed analysis and test are combined with probabilistic risk assessment to design this entirely passive concept that circumvents the potential failure modes of a parachute terminal descent system. The design also possesses features that mitigate other risks during the entry, descent, landing and recovery phases. The results of a full-scale drop test are summarized.

  14. Abrasion Collar Around Shrapnel Entry Wound.

    PubMed

    Gujaral, Pootheril Balan; Ajay, Balachandran

    2017-02-28

    Abrasion collar is usually described as a feature of bullet entry wounds caused by friction and indentation. The present case is that of the peculiar entry wound caused by a piece of flying shrapnel which was ejected from a furnace in a steel plant. The scrap metal which exploded in the plant was sourced from the West Asia region. The entry wound on the chest was circular and had an abrasion collar around it. The projectile was a cylindrical object of obscure origin. The forensic science laboratory put forth the possibility that the projectile was a component of an artillery fuze. A decades old study which employed high-speed photography has rejected the possibility that abrasion collars are produced by friction. High-velocity projectiles other than bullets can also produce abrasion collars as the rubbing of the bullet against the skin or its rotation are not the causative mechanisms.

  15. Writing and deleting single magnetic skyrmions.

    PubMed

    Romming, Niklas; Hanneken, Christian; Menzel, Matthias; Bickel, Jessica E; Wolter, Boris; von Bergmann, Kirsten; Kubetzka, André; Wiesendanger, Roland

    2013-08-09

    Topologically nontrivial spin textures have recently been investigated for spintronic applications. Here, we report on an ultrathin magnetic film in which individual skyrmions can be written and deleted in a controlled fashion with local spin-polarized currents from a scanning tunneling microscope. An external magnetic field is used to tune the energy landscape, and the temperature is adjusted to prevent thermally activated switching between topologically distinct states. Switching rate and direction can then be controlled by the parameters used for current injection. The creation and annihilation of individual magnetic skyrmions demonstrates the potential for topological charge in future information-storage concepts.

  16. Targeted gene deletion in Zygosaccharomyces bailii.

    PubMed

    Mollapour, M; Piper, P

    2001-01-30

    Yeasts of the genus Zygosaccharomyces are notable agents of large-scale food spoilage. Despite the economic importance of these organisms, little is known about the stress adaptations whereby they adapt to many of the more severe conditions of food preservation. In this study it was shown that genes of Z. bailii, a yeast notable for its high resistances to food preservatives and ethanol, can be isolated by complementation of the corresponding mutant strains of Saccharomyces cerevisiae. It was also discovered that the acquisition by S. cerevisiae of a single small Z. bailii gene (ZbYME2) was sufficient for the former yeast to acquire the ability to degrade two major food preservatives, benzoic acid and sorbic acid. Using DNA cassettes containing dominant selectable markers and methods originally developed for performing gene deletions in S. cerevisiae, the two copies of ZbYME2 in the Z. bailii genome were sequentially deleted. The resulting Zbyme2/Zbyme2 homozygous deletant strain had lost any ability to utilize benzoate as sole carbon source and was more sensitive to weak acid preservatives during growth on glucose. Thus, ZbYME2, probably the nuclear gene for a mitochondrial mono-oxygenase function, is essential for Z. bailii to degrade food preservatives. This ability to catabolize weak acid preservatives is a significant factor contributing to the preservative resistance of Z. bailii under aerobic conditions. This study is the first to demonstrate that it is possible to delete in Z. bailii genes that are suspected as being important for growth of this organism in preserved foods and beverages. With the construction of further mutant of Z. bailii strains, a clearer picture should emerge of how this yeast adapts to the conditions of food preservation. This information will, in turn, allow the design of new preservation strategies. GenBank Accession Nos: ZbURA3 (AF279259), ZbTIM9 (AF279260), ZbYME2 (AF279261), ZbTRP1 (AF279262), ZbHHT1(AF296170).

  17. General practice career intentions among graduate-entry students: a cross-sectional study at Ireland's newest medical school.

    PubMed

    Lane, G; Dunne, C; English, A; Finucane, P; O'Connor, R; Griffin, M; O'Sullivan, B; Hanrahan, C; McGrath, D; O'Donovan, N; Cullen, W

    2014-02-01

    Increased care provision and clinical activity in General Practice in Ireland will have important manpower implications. Recent developments in medical education policy including the introduction of graduate-entry medical degree programmes may help address this issue. The aim of this study was to determine GP career intentions among students on an Irish graduate-entry medical degree programme and to identify factors that influence these. An electronic cross-sectional study of students at University of Limerick Graduate-Entry Medical School (UL-GEMS) was undertaken. We received 139 replies (78% response rate). 41 (29%) reported GP was their current preferred career choice, while 29 (19%) reported it was their preferred career choice on entry to medical school. This first study to present data on GP career intentions among graduate-entry students in Ireland highlights the specialty as a popular preferred career choice among students, both on entry to, and during medical school. The study also identifies factors which are likely to be important in determining career intentions. Further research to examine this issue at other graduate-entry medical schools in Ireland and to determine whether our findings are pursued over time amongst graduates is a priority.

  18. Project Prometheus and Future Entry Probe Missions

    NASA Technical Reports Server (NTRS)

    Spilker, Thomas R.

    2005-01-01

    A viewgraph presentation on project Prometheus and future entry probe missions is shown. The topics include: 1) What Is Project Prometheus?; 2) What Capabilities Can Project Prometheus Offer? What Mission Types Are Being Considered?; 3) Jupiter Icy Moons Orbiter (JIMO); 4) How Are Mission Opportunities Changing?; 5) Missions Of Interest a Year Ago; 6) Missions Now Being Considered For Further Study; 7) Galileo-Style (Conventional) Probe Delivery; 8) Galileo-Style Probe Support; 9) Conventional Delivery and Support of Multiple Probes; 10) How Entry Probe Delivery From an NEP Vehicle Is Different; and 11) Concluding Remarks.

  19. Automated Re-Entry System using FNPEG

    NASA Technical Reports Server (NTRS)

    Johnson, Wyatt R.; Lu, Ping; Stachowiak, Susan J.

    2017-01-01

    This paper discusses the implementation and simulated performance of the FNPEG (Fully Numerical Predictor-corrector Entry Guidance) algorithm into GNC FSW (Guidance, Navigation, and Control Flight Software) for use in an autonomous re-entry vehicle. A few modifications to FNPEG are discussed that result in computational savings -- a change to the state propagator, and a modification to cross-range lateral logic. Finally, some Monte Carlo results are presented using a representative vehicle in both a high-fidelity 6-DOF (degree-of-freedom) sim as well as in a 3-DOF sim for independent validation.

  20. Computational Fluid Dynamics for Atmospheric Entry

    DTIC Science & Technology

    2009-09-01

    Atmospheric entry 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT... Atmospheric Entry 15 - 4 RTO-EN-AVT-162 and was performed on 16 million element hybrid unstructured grid. Not shown in this image is that the...conserved quantities and the non-conserved quantities such as pressure and temperature are discussed in this section. The total energy, E, is made up of

  1. STS-121: Discovery Entry Flight Director Post Landing Press Conference

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Steve Stitch, STS-121 Entry Flight Director, and Wayne Hale, Space Shuttle Program is shown in this post landing press conference. Steve Stitch begins with discussing the following topics: 1) Weather at Kennedy Space Center; 2) Gap filler protrusion; 3) De-orbit burn; 4) Space Shuttle Landing; 5) Global Position Satellite System (GPSS) performance; and 6) Post-landing rain showers. Wayne Hale discusses external tank observations at launch and the goals that were obtained by this flight, which are to deliver 4000 pounds of scientific equipment, increase the crew members to three on the International Space Station (ISS), and repair the ISS. Questions from the press on lessons learned from the Auxiliary Power Unit (APU) leak, and flight readiness reviews are addressed.

  2. AZF deletions in infertile men from the Republic of Macedonia.

    PubMed

    Plaseski, Toso; Novevski, Predrag; Kocevska, Borka; Dimitrovski, Cedomir; Efremov, Georgi D; Plaseska-Karanfilska, Dijana

    2006-07-01

    Y chromosome deletions in the three azoospermia factor (AZF) regions constitute the most common genetic cause of spermatogenic failure. The aim of this study was to estimate the length and boundaries of the AZF deletions and to correlate the AZF deletions with the sperm concentrations, testicular histology, Y haplogroups and the ethnic origin of the men with deletions. PCR analysis of STS loci in the three AZF regions was used to characterize the deletions. Y haplogroup was predicted from a set of 17 Y short tandem repeats (STR) marker values. A total of nine men out of 218 infertile/subfertile men showed the presence of Y microdeletions. In eight patients the results were consistent with the presence of AZFc deletions, while in one patient a larger deletion involving both AZFb and AZFc regions was detected. In two patients, the deletion, initially diagnosed as AZFc, involved part of the distal part of the AZFb region and in one of them the deletion also extended into the region distal to the AZFc. The 3.5 Mb AZFc deletion, due to homologous recombination between b2 and b4 amplicons, was detected in six men (66.7% of all Y deletions), thus being the most common type of AZF deletion among infertile men from the Republic of Macedonia. Patients with the 3.5 Mb AZFc deletion had azoospermia or severe oligozoospermia and variable histological results [Sertoly cell only syndrome (SCOS), maturity arrest (MA) and hypospermatogenesis (HSG)]. They were of different ethnic origin (Macedonian, Albanian and Romany) and belonged to different Y haplogroups (I1b, J2, E3b and G).

  3. Presence of Large Deletions in Kindreds with Autism

    PubMed Central

    Yu, Chang-En; Dawson, Geraldine; Munson, Jeffrey; D’Souza, Ian; Osterling, Julie; Estes, Annette; Leutenegger, Anne-Louise; Flodman, Pamela; Smith, Moyra; Raskind, Wendy H.; Spence, M. Anne; McMahon, William; Wijsman, Ellen M.; Schellenberg, Gerard D.

    2002-01-01

    Autism is caused, in part, by inheritance of multiple interacting susceptibility alleles. To identify these inherited factors, linkage analysis of multiplex families is being performed on a sample of 105 families with two or more affected sibs. Segregation patterns of short tandem repeat polymorphic markers from four chromosomes revealed null alleles at four marker sites in 12 families that were the result of deletions ranging in size from 5 to >260 kb. In one family, a deletion at marker D7S630 was complex, with two segments deleted (37 kb and 18 kb) and two retained (2,836 bp and 38 bp). Three families had deletions at D7S517, with each family having a different deletion (96 kb, 183 kb, and >69 kb). Another three families had deletions at D8S264, again with each family having a different deletion, ranging in size from <5.9 kb to >260 kb. At a fourth marker, D8S272, a 192-kb deletion was found in five families. Unrelated subjects and additional families without autism were screened for deletions at these four sites. Families screened included 40 families from Centre d'Etude du Polymorphisme Humaine and 28 families affected with learning disabilities. Unrelated samples were 299 elderly control subjects, 121 younger control subjects, and 248 subjects with Alzheimer disease. The deletion allele at D8S272 was found in all populations screened. For the other three sites, no additional deletions were identified in any of the groups without autism. Thus, these deletions appear to be specific to autism kindreds and are potential autism-susceptibility alleles. An alternative hypothesis is that autism-susceptibility alleles elsewhere cause the deletions detected here, possibly by inducing errors during meiosis. PMID:12058345

  4. Method for introducing unidirectional nested deletions

    DOEpatents

    Dunn, John J.; Quesada, Mark A.; Randesi, Matthew

    1999-07-27

    Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning vector having an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation. Also disclosed is a method for producing single-stranded DNA probes. In this embodiment, single-stranded gapped DNA, produced as described above, is contacted with a DNA polymerase in the presence of labeled nucleotides to fill in the gap. This DNA is then linearized by digestion with a restriction enzyme which cuts outside the DNA segment of interest. The product of this digestion is then denatured to produce a labeled single-stranded nucleic acid probe.

  5. Method for introducing unidirectional nested deletions

    DOEpatents

    Dunn, J.J.; Quesada, M.A.; Randesi, M.

    1999-07-27

    Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector. The cloning vector has an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation. Also disclosed is a method for producing single-stranded DNA probes. In this embodiment, single-stranded gapped DNA, produced as described above, is contacted with a DNA polymerase in the presence of labeled nucleotides to fill in the gap. This DNA is then linearized by digestion with a restriction enzyme which cuts outside the DNA segment of interest. The product of this digestion is then denatured to produce a labeled single-stranded nucleic acid probe. 1 fig.

  6. Deletion of ultraconserved elements yields viable mice

    SciTech Connect

    Ahituv, Nadav; Zhu, Yiwen; Visel, Axel; Holt, Amy; Afzal, Veena; Pennacchio, Len A.; Rubin, Edward M.

    2007-07-15

    Ultraconserved elements have been suggested to retainextended perfect sequence identity between the human, mouse, and ratgenomes due to essential functional properties. To investigate thenecessities of these elements in vivo, we removed four non-codingultraconserved elements (ranging in length from 222 to 731 base pairs)from the mouse genome. To maximize the likelihood of observing aphenotype, we chose to delete elements that function as enhancers in amouse transgenic assay and that are near genes that exhibit markedphenotypes both when completely inactivated in the mouse as well as whentheir expression is altered due to other genomic modifications.Remarkably, all four resulting lines of mice lacking these ultraconservedelements were viable and fertile, and failed to reveal any criticalabnormalities when assayed for a variety of phenotypes including growth,longevity, pathology and metabolism. In addition more targeted screens,informed by the abnormalities observed in mice where genes in proximityto the investigated elements had been altered, also failed to revealnotable abnormalities. These results, while not inclusive of all thepossible phenotypic impact of the deleted sequences, indicate thatextreme sequence constraint does not necessarily reflect crucialfunctions required for viability.

  7. FLPP IXV Re-Entry Vehicle, Hypersonic Aerodynamics Characterisation

    NASA Astrophysics Data System (ADS)

    Tran, Ph.; Dormieux, M.; Fontaine, J.; Gülhan, A.; Tribot, J.-P.; Binetti, P.; Walloschek, T.

    2009-01-01

    The general objective of the IXV project (Intermediate eXperimental Vehicle), led by NGL Prime in the framework of the ESA FLPP programme (Future Launchers Preparatory Programme), is to improve European capabilities in the strategic field of atmospheric re-entry for space transportation, exploration, and scientific applications. One of the key objectives and challenges of the IXV project is the vehicle re-entry guidance and control demonstration which requires an accurate determination of the aerodynamic characteristics. This paper deals with all the aerodynamic characterization in the hypersonic flow regime. Wind tunnel tests (WTT) and CFD matrices have been defined in order to provide good coverage of the foreseen flight domain, account for uncertainties, and exploit the synergy between experimental and computational activity. WTT have been performed in DLR-H2K (M=6 and 8.7) and ONERA-S4Ma (M=10) facilities, gathering forces and moment data, as well as pressure in key areas. Consistency of the two campaigns results will be addressed. These results have highlighted some flow peculiarities in the deflected flap region. Comparisons with CFD show good agreement with ground experimental results. For flight conditions, real gas and viscous effects play a significant role in the trim conditions that only CFD can currently address; this identification was supported by different partners involved in the project (CFS engineering, DLR, CIRA, and the University of Rome) providing a valuable description of key flow phenomena affecting aerodynamic characteristics. Moreover, at high altitude, limited DSMC computations have been performed for bridging function correction.

  8. Identifying and Addressing Vaccine Hesitancy

    PubMed Central

    Kestenbaum, Lori A.; Feemster, Kristen A.

    2015-01-01

    In the 20th century, the introduction of multiple vaccines significantly reduced childhood morbidity, mortality, and disease outbreaks. Despite, and perhaps because of, their public health impact, an increasing number of parents and patients are choosing to delay or refuse vaccines. These individuals are described as vaccine hesitant. This phenomenon has developed due to the confluence of multiple social, cultural, political and personal factors. As immunization programs continue to expand, understanding and addressing vaccine hesitancy will be crucial to their successful implementation. This review explores the history of vaccine hesitancy, its causes, and suggested approaches for reducing hesitancy and strengthening vaccine acceptance. PMID:25875982

  9. Identifying and addressing vaccine hesitancy.

    PubMed

    Kestenbaum, Lori A; Feemster, Kristen A

    2015-04-01

    In the 20th century, the introduction of multiple vaccines significantly reduced childhood morbidity, mortality, and disease outbreaks. Despite, and perhaps because of, their public health impact, an increasing number of parents and patients are choosing to delay or refuse vaccines. These individuals are described as "vaccine hesitant." This phenomenon has developed due to the confluence of multiple social, cultural, political, and personal factors. As immunization programs continue to expand, understanding and addressing vaccine hesitancy will be crucial to their successful implementation. This review explores the history of vaccine hesitancy, its causes, and suggested approaches for reducing hesitancy and strengthening vaccine acceptance.

  10. Nanoscale content-addressable memory

    NASA Technical Reports Server (NTRS)

    Davis, Bryan (Inventor); Principe, Jose C. (Inventor); Fortes, Jose (Inventor)

    2009-01-01

    A combined content addressable memory device and memory interface is provided. The combined device and interface includes one or more one molecular wire crossbar memories having spaced-apart key nanowires, spaced-apart value nanowires adjacent to the key nanowires, and configurable switches between the key nanowires and the value nanowires. The combination further includes a key microwire-nanowire grid (key MNG) electrically connected to the spaced-apart key nanowires, and a value microwire-nanowire grid (value MNG) electrically connected to the spaced-apart value nanowires. A key or value MNGs selects multiple nanowires for a given key or value.

  11. Addressing inequities in healthy eating.

    PubMed

    Friel, Sharon; Hattersley, Libby; Ford, Laura; O'Rourke, Kerryn

    2015-09-01

    What, when, where and how much people eat is influenced by a complex mix of factors at societal, community and individual levels. These influences operate both directly through the food system and indirectly through political, economic, social and cultural pathways that cause social stratification and influence the quality of conditions in which people live their lives. These factors are the social determinants of inequities in healthy eating. This paper provides an overview of the current evidence base for addressing these determinants and for the promotion of equity in healthy eating.

  12. Addressing the workforce pipeline challenge

    SciTech Connect

    Leonard Bond; Kevin Kostelnik; Richard Holman

    2006-11-01

    A secure and affordable energy supply is essential for achieving U.S. national security, in continuing U.S. prosperity and in laying the foundations to enable future economic growth. To meet this goal the next generation energy workforce in the U.S., in particular those needed to support instrumentation, controls and advanced operations and maintenance, is a critical element. The workforce is aging and a new workforce pipeline, to support both current generation and new build has yet to be established. The paper reviews the challenges and some actions being taken to address this need.

  13. RTLS entry ranging analysis. [space shuttle reentry trajectory

    NASA Technical Reports Server (NTRS)

    Crull, T. J.

    1975-01-01

    Definition of the ranging capability of a mission 3A return-to-launch-site entry is reported. The limits on downrange and crossrange are established at the initiation of RTLS entry so that terminal area energy management interface conditions were achieved satisfactorily. The downrange and crossrange limits were defined for both nominal RTLS entry conditions and a composite set of dispersed RTLS entry conditions. The results indicate a wide range of acceptable downrange and crossrange positions are available at RTLS entry initiation for nominal conditions. This is greatly reduced when dispersions are considered. For dispersed RTLS entry conditions, an 18 nautical mile range of acceptable downranges is available at zero crossrange.

  14. Are there ethnic differences in deletions in the dystrophin gene?

    SciTech Connect

    Banerjee, M.; Verma, I.C.

    1997-01-20

    We studied 160 cases of Duchenne muscular dystrophy (DMD) drawn from all parts of India, using multiplex PCR of 27 exons. Of these, 103 (64.4%) showed intragenic deletions. Most (69.7%) of the deletions involved exons 45-51. The phenotype of cases with deletion of single exons did not differ significantly from those with deletion of multiple exons. The distribution of deletions in studies from different countries was variable, but this was accounted for either by the small number of cases studied, or by fewer exons analyzed. It is concluded that there is likely to be no ethnic difference with respect to deletions in the DMD gene. 38 refs., 2 figs., 3 tabs.

  15. Thinking and Reading for Entry Level Workers.

    ERIC Educational Resources Information Center

    Allentown Literacy Council, PA.

    A pilot project demonstrated that cooperative training programs are effective and cost efficient for small businesses. Common entry-level reading and thinking tasks were identified in a variety of occupational areas. Five growing occupational areas were identified: industrial/machine operator; health care; food preparation; hotel/hospitality; and…

  16. 32 CFR 770.44 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New... upon Naval Submarine Base New London, or remaining thereon by any person for any purpose without the advance consent of the Commanding Officer, Naval Submarine Base New London, or his...

  17. 32 CFR 770.29 - Entry procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Installations in the State of Hawaii... requests by individuals to visit a naval installation. Consistent with such considerations, visits by... group desiring to enter a particular naval installation or portion thereof, shall submit a...

  18. 32 CFR 770.45 - Entry procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton... consent of the Commanding Officer, Naval Submarine Base New London, or his authorized representative shall, in writing, submit a request to the Commanding Officer, Naval Submarine Base New London, at...

  19. 32 CFR 763.4 - Entry restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... from Commander Naval Base. This prohibition applies to all areas of Kaho'olawe Island reserved for naval purposes by Executive Order 10436. (b) Entry by any person into the restricted waters adjacent to Kaho'olawe Island for any purpose is prohibited without advance authorization from Commander Naval...

  20. Food Distribution. The Supermarket Entry Occupations.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

    This guide is designed to assist the coordinator of the Marketing and Distributive Education Cooperative Education Program in improving and expanding the instructional activities needed to prepare individuals to function in the food industry's entry-level jobs. The instructional material provides information about what is expected of a student…

  1. 19 CFR 128.23 - Entry requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Entry requirements. 128.23 Section 128.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... utilizing the procedures in this part shall comply with the requirements of the Customs Automated...

  2. TEST CELL STUDIES OF RADON ENTRY

    EPA Science Inventory

    The report gives results of a study to contrast the effectiveness of slab-in-stem wall (SSW) with floating slab (FS) construction practices, to measure radon transport and entry for model testing, to develop protocols relevant to depressurized radon measurements, and to determine...

  3. HIV-1 Entry Inhbitors: An Overview

    PubMed Central

    Kuritzkes, Daniel R.

    2009-01-01

    Purpose of review This review provides an overview of HIV-1 entry inhibitors, with a focus on chemokine receptor antagonists. Recent findings Entry of HIV-1 into target cells is an ordered multi-step process involving attachment, co-receptor binding and fusion. Inhibitors of each step have been identified and shown to have antiviral activity in clinical trials. Phase 1-2 trials of monoclonal antibodies and small-molecule attachment inhibitors have demonstrated activity in HIV-1-infected subjects, but none has progressed to later phase clinical trials. The post-attachment inhibitor ibalizumab has shown activity in phase 1 and 2 trials; further studies are anticipated. The CCR5 antagonists maraviroc (now been approved for clinical use) and vicriviroc (in phase 3 trials) have shown significant benefit in controlled trials in treatment-experienced subjects; additional CCR5 antagonists are in various stages of clinical development. Targeting CXCR4 has proven to be more challenging. Although proof of concept has been demonstrated in phase 1-2 trials of two compounds, neither proved suitable for chronic administration. Little progress has been reported in developing longer acting or orally bioavailable fusion inhibitors. Summary ACCR5 antagonist and a fusion inhibitor are approved for use as HIV-1 entry inhibitors. Development of drugs targeting other steps in HIV-1 entry is ongoing. PMID:19339945

  4. Voice Data Entry in NISTARS Warehouses

    DTIC Science & Technology

    1993-01-28

    2.1 Advantages of Voice Interface Technology .......................................... 2 2.2 NISTARS W ork Station Overview...20 4. Voice Interface Implementation Plan .................................................................... 21 4.1 Integration Options...offers little opportunity for voice interface integration. Normal processing requires no more than a <Task Complete> key entry to the computer. Even

  5. Entry Level Skills Program Implementation Guide.

    ERIC Educational Resources Information Center

    Institute for Services to Education, Inc., Washington, DC.

    A guide to the implementation of the Entry Level Skills Program (ELSP) and a conceptual framework for evaluation research is presented. Attention is directed to strategies for the attainment of goals and management of the ELSP project, which is a developmental program for freshmen students who have not acquired the full range or level of cognitive…

  6. 32 CFR 770.44 - Entry restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New... upon Naval Submarine Base New London, or remaining thereon by any person for any purpose without the advance consent of the Commanding Officer, Naval Submarine Base New London, or his...

  7. 32 CFR 770.45 - Entry procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton... consent of the Commanding Officer, Naval Submarine Base New London, or his authorized representative shall, in writing, submit a request to the Commanding Officer, Naval Submarine Base New London, at...

  8. 32 CFR 770.45 - Entry procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton... consent of the Commanding Officer, Naval Submarine Base New London, or his authorized representative shall, in writing, submit a request to the Commanding Officer, Naval Submarine Base New London, at...

  9. 32 CFR 770.44 - Entry restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New... upon Naval Submarine Base New London, or remaining thereon by any person for any purpose without the advance consent of the Commanding Officer, Naval Submarine Base New London, or his...

  10. 32 CFR 770.45 - Entry procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton... consent of the Commanding Officer, Naval Submarine Base New London, or his authorized representative shall, in writing, submit a request to the Commanding Officer, Naval Submarine Base New London, at...

  11. 32 CFR 770.45 - Entry procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton... consent of the Commanding Officer, Naval Submarine Base New London, or his authorized representative shall, in writing, submit a request to the Commanding Officer, Naval Submarine Base New London, at...

  12. 32 CFR 770.44 - Entry restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New... upon Naval Submarine Base New London, or remaining thereon by any person for any purpose without the advance consent of the Commanding Officer, Naval Submarine Base New London, or his...

  13. 32 CFR 770.44 - Entry restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... LIMITING PUBLIC ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New... upon Naval Submarine Base New London, or remaining thereon by any person for any purpose without the advance consent of the Commanding Officer, Naval Submarine Base New London, or his...

  14. Radiation and critical shocks in atmospheric entry

    SciTech Connect

    Canavan, G.H.

    1997-12-01

    Sub- and supercritical shock waves are produced during atmospheric entry. The radiation efficiency of the former increases strongly with velocity and altitude; that of the latter increases with altitude, but decreases with supercritical velocities. These efficiencies shift the region of maximum radiation one to two scale heights higher and decrease overall radiation efficiency.

  15. Simplified modeling for infiltration and radon entry

    SciTech Connect

    Sherman, M.H.

    1992-08-01

    Air leakage in the envelopes of residential buildings is the primary mechanism for provided ventilation to those buildings. For radon the same mechanisms that drive the ventilation, drive the radon entry This paper attempts to provide a simplified physical model that can be used to understand the interactions between the building leakage distribution, the forces that drive infiltration and ventilation, and indoor radon concentrations, Combining both ventilation and entry modeling together allows an estimation of Radon concentration and exposure to be made and demonstrates how changes in the envelope or ventilation system would affect it. This paper will develop simplified modeling approaches for estimating both ventilation rate and radon entry rate based on the air tightness of the envelope and the driving forces. These approaches will use conventional leakage values (i.e. effective leakage area ) to quantify the air tightness and include natural and mechanical driving forces. This paper will introduce a simplified parameter, the Radon Leakage Area, that quantifies the resistance to radon entry. To be practical for dwellings, modeling of the occupant exposures to indoor pollutants must be simple to use and not require unreasonable input data. This paper presents the derivation of the simplified physical model, and applies that model to representative situations to explore the tendencies to be expected under different circumstances.

  16. 19 CFR 128.23 - Entry requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... System (ACS). These requirements include those under the Automated Manifest System (AMS), Cargo Selectivity, Statement Processing, the Automated Broker Interface System (ABI), and enhancements of ACS. (2... Commercial System (ACS). (3) Paper entry document waiver. The port director is authorized, at the time...

  17. Managed entry agreements for pharmaceuticals in Australia.

    PubMed

    Vitry, Agnes; Roughead, Elizabeth

    2014-09-01

    In Australia, a number of managed entry agreements have been developed to enable national coverage of new medicines. Non-outcome based agreements are usually pricing arrangements that involve price or volume rebate agreements. In February 2013, there were at least 71 special pricing arrangements in place, including 26 for medicines restricted to use in hospitals. Health outcome based agreements can be made at the individual or population level. At the individual level, there were 28 medicines funded subject to continuation rules involving documentation of adequate benefit within the individual; some of these medicines also had price agreements in place. At the population level, only one outcome-based agreement has been implemented so far, for bosentan, a medicine marketed for pulmonary hypertension. In May 2010, a memorandum of understanding signed between the Australian Government and Medicines Australia, the peak pharmaceutical industry organisation, included the possibility for industry to request consideration of a 'Managed Entry Scheme' as part of the funding submission process for medicines with high clinical needs. It includes the possibility of a randomised controlled trial (RCT)-based entry scheme. Although this form of managed entry has yet not been trialed in Australia, several 2012/2013 funding recommendations included requests by the decision making committee for further evidence development.

  18. Shuttle Entry Imaging Using Infrared Thermography

    NASA Technical Reports Server (NTRS)

    Horvath, Thomas; Berry, Scott; Alter, Stephen; Blanchard, Robert; Schwartz, Richard; Ross, Martin; Tack, Steve

    2007-01-01

    During the Columbia Accident Investigation, imaging teams supporting debris shedding analysis were hampered by poor entry image quality and the general lack of information on optical signatures associated with a nominal Shuttle entry. After the accident, recommendations were made to NASA management to develop and maintain a state-of-the-art imagery database for Shuttle engineering performance assessments and to improve entry imaging capability to support anomaly and contingency analysis during a mission. As a result, the Space Shuttle Program sponsored an observation campaign to qualitatively characterize a nominal Shuttle entry over the widest possible Mach number range. The initial objectives focused on an assessment of capability to identify/resolve debris liberated from the Shuttle during entry, characterization of potential anomalous events associated with RCS jet firings and unusual phenomenon associated with the plasma trail. The aeroheating technical community viewed the Space Shuttle Program sponsored activity as an opportunity to influence the observation objectives and incrementally demonstrate key elements of a quantitative spatially resolved temperature measurement capability over a series of flights. One long-term desire of the Shuttle engineering community is to calibrate boundary layer transition prediction methodologies that are presently part of the Shuttle damage assessment process using flight data provided by a controlled Shuttle flight experiment. Quantitative global imaging may offer a complementary method of data collection to more traditional methods such as surface thermocouples. This paper reviews the process used by the engineering community to influence data collection methods and analysis of global infrared images of the Shuttle obtained during hypersonic entry. Emphasis is placed upon airborne imaging assets sponsored by the Shuttle program during Return to Flight. Visual and IR entry imagery were obtained with available airborne

  19. NPL deletion policy for RCRA-regulated TSD facilities finalized

    SciTech Connect

    1995-05-01

    Under a new policy published by EPA on March 20, 1995, certain sites may be deleted from the National Priorities List (NPL) and deferred to RCRA corrective action. To be deleted from the NPL, a site must (1) be regulated under RCRA as a treatment, storage, or disposal (TSD) facility and (2) meet the four criteria specified by EPA. The new NPL deletion policy, which does not pertain to federal TSD facilities, became effective on April 19, 1995. 1 tab.

  20. Content-addressable holographic databases

    NASA Astrophysics Data System (ADS)

    Grawert, Felix; Kobras, Sebastian; Burr, Geoffrey W.; Coufal, Hans J.; Hanssen, Holger; Riedel, Marc; Jefferson, C. Michael; Jurich, Mark C.

    2000-11-01

    Holographic data storage allows the simultaneous search of an entire database by performing multiple optical correlations between stored data pages and a search argument. We have recently developed fuzzy encoding techniques for this fast parallel search and demonstrated a holographic data storage system that searches digital data records with high fidelity. This content-addressable retrieval is based on the ability to take the two-dimensional inner product between the search page and each stored data page. We show that this ability is lost when the correlator is defocussed to avoid material oversaturation, but can be regained by the combination of a random phase mask and beam confinement through total internal reflection. Finally, we propose an architecture in which spatially multiplexed holograms are distributed along the path of the search beam, allowing parallel search of large databases.

  1. Addressing viral resistance through vaccines

    PubMed Central

    Laughlin, Catherine; Schleif, Amanda; Heilman, Carole A

    2015-01-01

    Antimicrobial resistance is a serious healthcare concern affecting millions of people around the world. Antiviral resistance has been viewed as a lesser threat than antibiotic resistance, but it is important to consider approaches to address this growing issue. While vaccination is a logical strategy, and has been shown to be successful many times over, next generation viral vaccines with a specific goal of curbing antiviral resistance will need to clear several hurdles including vaccine design, evaluation and implementation. This article suggests that a new model of vaccination may need to be considered: rather than focusing on public health, this model would primarily target sectors of the population who are at high risk for complications from certain infections. PMID:26604979

  2. Addressing Failures in Exascale Computing

    SciTech Connect

    Snir, Marc; Wisniewski, Robert; Abraham, Jacob; Adve, Sarita; Bagchi, Saurabh; Balaji, Pavan; Belak, J.; Bose, Pradip; Cappello, Franck; Carlson, Bill; Chien, Andrew; Coteus, Paul; DeBardeleben, Nathan; Diniz, Pedro; Engelmann, Christian; Erez, Mattan; Fazzari, Saverio; Geist, Al; Gupta, Rinku; Johnson, Fred; Krishnamoorthy, Sriram; Leyffer, Sven; Liberty, Dean; Mitra, Subhasish; Munson, Todd; Schreiber, Rob; Stearley, Jon; Van Hensbergen, Eric

    2014-01-01

    We present here a report produced by a workshop on Addressing failures in exascale computing' held in Park City, Utah, 4-11 August 2012. The charter of this workshop was to establish a common taxonomy about resilience across all the levels in a computing system, discuss existing knowledge on resilience across the various hardware and software layers of an exascale system, and build on those results, examining potential solutions from both a hardware and software perspective and focusing on a combined approach. The workshop brought together participants with expertise in applications, system software, and hardware; they came from industry, government, and academia, and their interests ranged from theory to implementation. The combination allowed broad and comprehensive discussions and led to this document, which summarizes and builds on those discussions.

  3. Addressing failures in exascale computing

    SciTech Connect

    Snir, Marc; Wisniewski, Robert W.; Abraham, Jacob A.; Adve, Sarita; Bagchi, Saurabh; Balaji, Pavan; Belak, Jim; Bose, Pradip; Cappello, Franck; Carlson, William; Chien, Andrew A.; Coteus, Paul; Debardeleben, Nathan A.; Diniz, Pedro; Engelmann, Christian; Erez, Mattan; Saverio, Fazzari; Geist, Al; Gupta, Rinku; Johnson, Fred; Krishnamoorthy, Sriram; Leyffer, Sven; Liberty, Dean; Mitra, Subhasish; Munson, Todd; Schreiber, Robert; Stearly, Jon; Van Hensbergen, Eric

    2014-05-01

    We present here a report produced by a workshop on “Addressing Failures in Exascale Computing” held in Park City, Utah, August 4–11, 2012. The charter of this workshop was to establish a common taxonomy about resilience across all the levels in a computing system; discuss existing knowledge on resilience across the various hardware and software layers of an exascale system; and build on those results, examining potential solutions from both a hardware and software perspective and focusing on a combined approach. The workshop brought together participants with expertise in applications, system software, and hardware; they came from industry, government, and academia; and their interests ranged from theory to implementation. The combination allowed broad and comprehensive discussions and led to this document, which summarizes and builds on those discussions.

  4. Light addressable photoelectrochemical cyanide sensor

    SciTech Connect

    Licht, S.; Myung, N.; Sun, Y.

    1996-03-15

    A sensor is demonstrated that is capable of spatial discrimination of cyanide with use of only a single stationary sensing element. Different spatial regions of the sensing element are light activated to reveal the solution cyanide concentration only at the point of illumination. In this light addressable photoelectrochemical (LAP) sensor the sensing element consists of an n-CdSe electrode immersed in solution, with the open-circuit potential determined under illumination. In alkaline ferro-ferri-cyanide solution, the open-circuit photopotential is highly responsive to cyanide, with a linear response of (120 mV) log [KCN]. LAP detection with a spatial resolution of {+-}1 mm for cyanide detection is demonstrated. The response is almost linear for 0.001-0.100 m cyanide with a resolution of 5 mV. 38 refs., 7 figs., 1 tab.

  5. Molecular mapping within the mouse albino-deletion complex.

    PubMed

    Johnson, D K; Hand, R E; Rinchik, E M

    1989-11-01

    Induced germ-line deletion mutations in the mouse provide a malleable experimental system for in-depth molecular and functional analysis of large segments of the mammalian genome. To obtain an initial bank of molecular probes for the region of mouse chromosome 7 associated with the albino-deletion complex, random anonymous DNA clones, derived from a library constructed from flow-sorted chromosomes, were screened on DNAs from Mus musculus-Mus spretus F1 hybrids carrying large, multilocus, lethal albino deletions. Clones falling within a given deletion interval can easily be recognized because hybridization bands that represent restriction fragment length polymorphisms specific for the mutant (deleted) chromosome inherited from the M. musculus parent will be absent. Among 72 informative clones used as probes, one, which defines the locus D7OR1, mapped within two deletions that are 6-11 centimorgans in length. Submapping of this anonymous clone across a panel of 27 smaller deletions localized D7OR1 distal to a chromosomal subregion important for survival of the preimplantation embryo, proximal to globin [beta-chain (Hbb)], and near the shaker-1 (sh-1) locus. The results of these deletion-mapping experiments were also confirmed by standard three-point linkage analysis. This strategy for selection and rapid mapping of anonymous DNA probes to chromosomal segments corresponding to germ-line deletion mutations should contribute to the generation of more detailed physical and functional maps of genomic regions associated with mutant developmental phenotypes.

  6. Comprehensive Analysis of Pathogenic Deletion Variants in Fanconi Anemia Genes

    PubMed Central

    Flynn, Elizabeth K.; Kamat, Aparna; Lach, Francis P.; Donovan, Frank X.; Kimble, Danielle C.; Narisu, Narisu; Sanborn, Erica; Boulad, Farid; Davies, Stella M.; Gillio, Alfred P.; Harris, Richard E.; MacMillan, Margaret L.; Wagner, John E.; Smogorzewska, Agata; Auerbach, Arleen D.; Ostrander, Elaine A.; Chandrasekharappa, Settara C.

    2014-01-01

    Fanconi anemia (FA) is a rare recessive disease resulting from mutations in one of at least 16 different genes. Mutation types and phenotypic manifestations of FA are highly heterogeneous and influence the clinical management of the disease. We analyzed 202 FA families for large deletions, using high-resolution Comparative Genome Hybridization arrays (arrayCGH), Single Nucleotide Polymorphism arrays (SNParrays) and DNA sequencing. We found pathogenic deletions in 88 FANCA, seven FANCC, two FANCD2, and one FANCB families. We find 35% of FA families carry large deletions, accounting for 18% of all FA pathogenic variants. Cloning and sequencing across the deletion breakpoints revealed that 52 FANCA deletion ends, and one FANCC deletion end extended beyond the gene boundaries, potentially affecting neighboring genes with phenotypic consequences. Seventy-five percent of the FANCA deletions are Alu-Alu mediated, predominantly by AluY elements, and appear to be caused by Non-Allelic Homologous Recombination. Individual Alu hotspots were identified. Defining the haplotypes of four FANCA deletions shared by multiple families revealed that three share a common ancestry. Knowing the exact molecular changes that lead to the disease may be critical for a better understanding of the FA phenotype, and to gain insight into the mechanisms driving these pathogenic deletion variants. PMID:25168418

  7. Deletion mapping of genetic regions associated with apomixis in Hieracium.

    PubMed

    Catanach, Andrew S; Erasmuson, Sylvia K; Podivinsky, Ellen; Jordan, Brian R; Bicknell, Ross

    2006-12-05

    Although apomixis has been quoted as a technology with the potential to deliver benefits similar in scale to those achieved with the Green Revolution, very little is currently known of the genetic mechanisms that control this trait in plants. To address this issue, we developed Hieracium, a genus of daisies native to Eurasia and North America, as a genetic model to study apomixis. In a molecular mapping study, we defined the number of genetic loci involved in apomixis, and we explored dominance and linkage relationships between these loci. To avoid difficulties often encountered with inheritance studies of apomicts, we based our mapping effort on the use of deletion mutagenesis, coupled with amplified fragment length polymorphism (AFLP) as a genomic fingerprinting tool. The results indicate that apomixis in Hieracium caespitosum is controlled at two principal loci, one of which regulates events associated with the avoidance of meiosis (apomeiosis) and the other, an unlinked locus that controls events associated with the avoidance of fertilization (parthenogenesis). AFLP bands identified as central to both loci were isolated, sequenced, and used to develop sequence-characterized amplified region (SCAR) markers. The validity of the AFLP markers was verified by using a segregating population generated by hybridization. The validity of the SCAR markers was verified by their pattern of presence/absence in specific mutants. The mutants, markers, and genetic data derived from this work are now being used to isolate genes controlling apomixis in this system.

  8. Deletion of Carboxypeptidase N Delays Onset of Experimental Cerebral Malaria

    PubMed Central

    Darley, M. M.; Ramos, T.N.; Wetsel, R.A.; Barnum, S.R.

    2012-01-01

    SUMMARY Complement contributes to inflammation during pathogen infections, however less is known regarding its role during malaria and, the severest form of the disease, cerebral malaria. Recent studies have shown that deletion of the complement anaphylatoxins receptors, C3aR and C5aR, does alter disease susceptibility in experimental cerebral malaria (ECM). This does not however, preclude C3a- and C5a-mediated contributions to inflammation in ECM and raises the possibility that carboxypeptidase regulation of anaphylatoxin activity rapidly over rides their functions. To address this question we performed ECM using carboxypeptidase N-deficient (CPN−/−) mice. Unexpectedly, we found that CPN−/− mice survived longer than wild type mice but were fully susceptible to ECM. CD4+ and CD8+ T cell infiltration was not reduced at the peak of disease in CPN−/− mice and there was no corresponding reduction in pro-inflammatory cytokine production. Our results indicate that carboxypeptidases contribute to the pathogenesis of ECM and that, studies examining the contribution of other carboxypeptidase families and family members may provide greater insight into the role these enzymes play in malaria. PMID:22708514

  9. Deletion of carboxypeptidase N delays onset of experimental cerebral malaria.

    PubMed

    Darley, M M; Ramos, T N; Wetsel, R A; Barnum, S R

    2012-01-01

    Complement contributes to inflammation during pathogen infections; however, less is known regarding its role during malaria and in the severest form of the disease, cerebral malaria. Recent studies have shown that deletion of the complement anaphylatoxins receptors, C3aR and C5aR, does not alter disease susceptibility in experimental cerebral malaria (ECM). This does not, however, preclude C3a- and C5a-mediated contributions to inflammation in ECM and raises the possibility that carboxypeptidase regulation of anaphylatoxin activity rapidly over rides their functions. To address this question, we performed ECM using carboxypeptidase N-deficient (CPN(-/-)) mice. Unexpectedly, we found that CPN(-/-) mice survived longer than wild-type mice, but they were fully susceptible to ECM. CD4(+) and CD8(+) T cell infiltration was not reduced at the peak of disease in CPN(-/-) mice, and there was no corresponding reduction in pro-inflammatory cytokine production. Our results indicate that carboxypeptidases contribute to the pathogenesis of ECM and that studies examining the contribution of other carboxypeptidase families and family members may provide greater insight into the role these enzymes play in malaria.

  10. Analytic Guidance for the First Entry in a Skip Atmospheric Entry

    NASA Technical Reports Server (NTRS)

    Garcia-Llama, Eduardo

    2007-01-01

    This paper presents an analytic method to generate a reference drag trajectory for the first entry portion of a skip atmospheric entry. The drag reference, expressed as a polynomial function of the velocity, will meet the conditions necessary to fit the requirements of the complete entry phase. The generic method proposed to generate the drag reference profile is further simplified by thinking of the drag and the velocity as density and cumulative distribution functions respectively. With this notion it will be shown that the reference drag profile can be obtained by solving a linear algebraic system of equations. The resulting drag profile is flown using the feedback linearization method of differential geometric control as guidance law with the error dynamics of a second order homogeneous equation in the form of a damped oscillator. This approach was first proposed as a revisited version of the Space Shuttle Orbiter entry guidance. However, this paper will show that it can be used to fly the first entry in a skip entry trajectory. In doing so, the gains in the error dynamics will be changed at a certain point along the trajectory to improve the tracking performance.

  11. 76 FR 28057 - Agency Information Collection Activities: Request for Entry or Departure for Flights To and From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... of Management and Budget. Comments should be addressed to the OMB Desk Officer for Customs and Border... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Request for Entry or Departure for Flights To and From Cuba AGENCY: U.S. Customs and Border Protection, Department of...

  12. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  13. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  14. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  15. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  16. 19 CFR 151.64 - Extra copy of entry summary.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate...

  17. 9. INTERIOR, VIEW SHOWING MAIN STAIRWAY AND ENTRY HALL THROUGH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. INTERIOR, VIEW SHOWING MAIN STAIRWAY AND ENTRY HALL THROUGH ENTRY INTO PARLOR. TAKEN FROM SOUTHWEST CORNER OF PARLOR, LOOKING NORTHWEST - Farquhar House, 1601 Sandy Spring Road (Route 108), Sandy Spring, Montgomery County, MD

  18. The HIV-1 Entry Process: A Stoichiometric View.

    PubMed

    Brandenberg, Oliver F; Magnus, Carsten; Regoes, Roland R; Trkola, Alexandra

    2015-12-01

    HIV-1 infection starts with fusion of the viral and the host cell membranes, a process mediated by the HIV-1 envelope glycoprotein trimer. The number of trimers required to complete membrane fusion, referred to as HIV-1 entry stoichiometry, remains under debate. A precise definition of HIV-1 entry stoichiometry is important as it reflects the efficacy of the viral entry process and steers the infectivity of HIV-1 virion populations. Initial estimates suggested a unanimous entry stoichiometry across HIV-1 strains while recent findings showed that HIV-1 strains can differ in entry stoichiometry. Here, we review current analyses of HIV-1 entry stoichiometry and point out future research directions to further define the interplay between entry stoichiometry, virus entry fitness, transmission, and susceptibility to antibody neutralization.

  19. 19 CFR 142.3a - Entry numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is...

  20. 19 CFR 142.3a - Entry numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is...

  1. 19 CFR 142.3a - Entry numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is...

  2. 19 CFR 142.3a - Entry numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is...

  3. 19 CFR 142.3a - Entry numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is...

  4. 7 CFR 319.69-3 - Entry inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Packing Materials Rules and Regulations § 319.69-3 Entry inspection. All packing materials shall be subject to inspection at time of entry....

  5. View of entry portal into bomb shelter. Wood blocking has ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of entry portal into bomb shelter. Wood blocking has been installed to prevent entry, view facing northwest - U.S. Naval Base, Pearl Harbor, Splinterproof Shelter, Seventh Street between Avenues E & G, Pearl City, Honolulu County, HI

  6. View of entry portal into bomb shelter. Wood blocking has ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of entry portal into bomb shelter. Wood blocking has been installed to prevent entry, view facing north - U.S. Naval Base, Pearl Harbor, Splinterproof Shelter, Seventh Street between Avenues E & G, Pearl City, Honolulu County, HI

  7. Stair and entry room, bunkhouse, first floor interior. Door from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Stair and entry room, bunkhouse, first floor interior. Door from entry hall leads to toilets and bathing rooms. A coat and hat rack is on each side of the door. - Sespe Ranch, Bunkhouse, 2896 Telegraph Road, Fillmore, Ventura County, CA

  8. Local Calcium Entry and the Guidance of Growth

    NASA Technical Reports Server (NTRS)

    Robinson, K. R.

    1983-01-01

    The role of calcium in developing cells is illustrated. The Fucus egg, a brown algae is used to describe this phenomenom. Results of local calcium entry and forced calcium entry into the eggs are given.

  9. ISBD (S) and Title Main Entry for Serials

    ERIC Educational Resources Information Center

    Spalding, C. Sumner

    1975-01-01

    I shall side with the IFLA 1961 decision to accord main entry under corporate bodies for the publications resulting from their corporate activity, monographic or serial. I find the case for arbitrary entry under title to be essentially weak. (Author)

  10. A region addresses patient safety.

    PubMed

    Feinstein, Karen Wolk; Grunden, Naida; Harrison, Edward I

    2002-06-01

    The Pittsburgh Regional Healthcare Initiative (PRHI) is a coalition of 35 hospitals, 4 major insurers, more than 30 major and small-business health care purchasers, dozens of corporate and civic leaders, organized labor, and partnerships with state and federal government all working together to deliver perfect patient care throughout Southwestern Pennsylvania. PRHI believes that in pursuing perfection, many of the challenges facing today's health care delivery system (eg, waste and error in the delivery of care, rising costs, frustration and shortage among clinicians and workers, financial distress, overcapacity, and lack of access to care) will be addressed. PRHI has identified patient safety (nosocomial infections and medication errors) and 5 clinical areas (obstetrics, orthopedic surgery, cardiac surgery, depression, and diabetes) as ideal starting points. In each of these areas of work, PRHI partners have assembled multifacility/multidisciplinary groups charged with defining perfection, establishing region-wide reporting systems, and devising and implementing recommended improvement strategies and interventions. Many design and conceptual elements of the PRHI strategy are adapted from the Toyota Production System and its Pittsburgh derivative, the Alcoa Business System. PRHI is in the proof-of-concept phase of development.

  11. 9 CFR 98.9 - Embryos refused entry.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Embryos refused entry. 98.9 Section 98... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.9 Embryos refused entry. Any embryo refused entry into...

  12. 9 CFR 98.9 - Embryos refused entry.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Embryos refused entry. 98.9 Section 98... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.9 Embryos refused entry. Any embryo refused entry into...

  13. 9 CFR 98.9 - Embryos refused entry.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Embryos refused entry. 98.9 Section 98... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.9 Embryos refused entry. Any embryo refused entry into...

  14. 9 CFR 98.9 - Embryos refused entry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Embryos refused entry. 98.9 Section 98... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.9 Embryos refused entry. Any embryo refused entry into...

  15. 9 CFR 98.9 - Embryos refused entry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Embryos refused entry. 98.9 Section 98... EMBRYOS AND ANIMAL SEMEN Ruminant and Swine Embryos from Regions Free of Rinderpest and Foot-and-Mouth Disease; and Embryos of Horses and Asses § 98.9 Embryos refused entry. Any embryo refused entry into...

  16. 7 CFR 322.21 - Post-entry handling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Will the facility's entryways, windows, and other structures, including water, air, and waste handling... 7 Agriculture 5 2011-01-01 2011-01-01 false Post-entry handling. 322.21 Section 322.21 Agriculture... Organisms § 322.21 Post-entry handling. (a) Immediately following clearance at the port of entry,...

  17. 19 CFR 128.25 - Formal entry procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Formal entry procedures. 128.25 Section 128.25... TREASURY EXPRESS CONSIGNMENTS Procedures § 128.25 Formal entry procedures. Formal entry, as provided for under 19 U.S.C. 1484 in parts 141, 142, and 143 (except for subpart C), of this chapter, is required...

  18. Open Entry/Open Exit Study. Final Report.

    ERIC Educational Resources Information Center

    Berg, Marvin

    Open entry/open exit refers to formats and procedures which allow learners to enter a program whenever they are ready and available, and allows them to leave or complete programs when competencies for job entry are attained. This study sought to provide base data on the concept of open entry/open exit by surveying involved individuals and to…

  19. 31 CFR 357.0 - Book-entry systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Book-entry systems. 357.0 Section 357..., DEPARTMENT OF THE TREASURY BUREAU OF THE FISCAL SERVICE REGULATIONS GOVERNING BOOK-ENTRY TREASURY BONDS... General Information § 357.0 Book-entry systems. (a) Treasury securities. Treasury securities...

  20. 31 CFR 337.6 - Conversions to book-entry.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Conversions to book-entry. 337.6... HOUSING ADMINISTRATION DEBENTURES Certificated Debentures § 337.6 Conversions to book-entry. Upon implementation of the book-entry debenture system, to be announced in advance by separate public notice, all...

  1. 31 CFR 337.6 - Conversions to book-entry.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Conversions to book-entry. 337.6... HOUSING ADMINISTRATION DEBENTURES Certificated Debentures § 337.6 Conversions to book-entry. Upon implementation of the book-entry debenture system, to be announced in advance by separate public notice, all...

  2. 31 CFR 337.6 - Conversions to book-entry.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Conversions to book-entry. 337.6... HOUSING ADMINISTRATION DEBENTURES Certificated Debentures § 337.6 Conversions to book-entry. Upon implementation of the book-entry debenture system, to be announced in advance by separate public notice, all...

  3. 31 CFR 337.6 - Conversions to book-entry.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Conversions to book-entry. 337.6... FEDERAL HOUSING ADMINISTRATION DEBENTURES Certificated Debentures § 337.6 Conversions to book-entry. Upon implementation of the book-entry debenture system, to be announced in advance by separate public notice, all...

  4. 31 CFR 357.0 - Book-entry systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Book-entry systems. 357.0 Section 357..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING BOOK-ENTRY TREASURY BONDS, NOTES... General Information § 357.0 Book-entry systems. (a) Treasury securities. Treasury securities...

  5. 31 CFR 357.0 - Book-entry systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Book-entry systems. 357.0 Section 357..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING BOOK-ENTRY TREASURY BONDS, NOTES... General Information § 357.0 Book-entry systems. (a) Treasury securities. Treasury securities...

  6. 31 CFR 357.0 - Book-entry systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Book-entry systems. 357.0 Section 357..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING BOOK-ENTRY TREASURY BONDS, NOTES... General Information § 357.0 Book-entry systems. (a) Treasury securities. Treasury securities...

  7. 14 CFR 375.24 - Entry and clearance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Entry and clearance. 375.24 Section 375.24 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) SPECIAL... Entry and clearance. All U.S. entry and clearance requirements for aircraft, passengers, crews,...

  8. 77 FR 5681 - Establishment of Global Entry Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... assist in developing a marketing strategy. The firm has created a new Global Entry logo and tag line... and 235 RIN 1651-AA73 Establishment of Global Entry Program AGENCY: U.S. Customs and Border Protection... international trusted traveler program called Global Entry. This voluntary program allows U.S. Customs...

  9. Requirements for Entry to Higher Education in the European Community.

    ERIC Educational Resources Information Center

    EURYDICE European Unit, Brussels (Belgium).

    This report provides information about student mobility within the European Community, and how it is linked to the requirements for entry to higher education. The report is divided into two sections. The first is a brief discussion of the six specific factors studied: (1) entry requirement qualifications and examinations; (2) entry requirement…

  10. 50 CFR 660.334 - Limited entry permits-endorsements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... permit with an “A” endorsement entitles the holder to participate in the limited entry fishery for all... transferable with the limited entry permit to another person, or to a different vessel under the same ownership under § 660.335. An “A” endorsement expires on failure to renew the limited entry permit to which it...

  11. 9 CFR 590.430 - Limitation on entry of material.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Entry of Material into Official Egg Products Plants § 590.430 Limitation on entry of material. (a) The Administrator shall limit the entry of eggs and egg products and other materials into official plants under...

  12. 9 CFR 590.430 - Limitation on entry of material.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Entry of Material into Official Egg Products Plants § 590.430 Limitation on entry of material. (a) The Administrator shall limit the entry of eggs and egg products and other materials into official plants under...

  13. 9 CFR 590.430 - Limitation on entry of material.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Entry of Material into Official Egg Products Plants § 590.430 Limitation on entry of material. (a) The Administrator shall limit the entry of eggs and egg products and other materials into official plants under...

  14. 9 CFR 590.430 - Limitation on entry of material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Entry of Material into Official Egg Products Plants § 590.430 Limitation on entry of material. (a) The Administrator shall limit the entry of eggs and egg products and other materials into official plants under...

  15. 9 CFR 590.430 - Limitation on entry of material.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE EGG PRODUCTS INSPECTION INSPECTION OF EGGS AND EGG PRODUCTS (EGG PRODUCTS INSPECTION ACT) Entry of Material into Official Egg Products Plants § 590.430 Limitation on entry of material. (a) The Administrator shall limit the entry of eggs and egg products and other materials into official plants under...

  16. 30 CFR 877.11 - Written consent for entry.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Written consent for entry. 877.11 Section 877... ABANDONED MINE LAND RECLAMATION RIGHTS OF ENTRY § 877.11 Written consent for entry. Written consent from the... police power will be undertaken only after reasonable efforts have been made to obtain written consent....

  17. 30 CFR 877.11 - Written consent for entry.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Written consent for entry. 877.11 Section 877... ABANDONED MINE LAND RECLAMATION RIGHTS OF ENTRY § 877.11 Written consent for entry. Written consent from the... police power will be undertaken only after reasonable efforts have been made to obtain written consent....

  18. 30 CFR 877.11 - Written consent for entry.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Written consent for entry. 877.11 Section 877... ABANDONED MINE LAND RECLAMATION RIGHTS OF ENTRY § 877.11 Written consent for entry. Written consent from the... police power will be undertaken only after reasonable efforts have been made to obtain written consent....

  19. 19 CFR 143.16 - Substitution of warehouse entry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Substitution of warehouse entry. 143.16 Section 143.16 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... warehouse entry. The importer may substitute an entry for warehouse at any time within 1 year from the...

  20. 7 CFR 322.20 - Ports of entry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Organisms § 322.20 Ports of entry. A restricted organism may be imported only at a port of entry staffed by an APHIS inspector. 5 After a restricted organism has been cleared for importation at the port of entry, the organism can only be transported by a bonded commercial carrier immediately and directly...

  1. 7 CFR 322.20 - Ports of entry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Organisms § 322.20 Ports of entry. A restricted organism may be imported only at a port of entry staffed by an APHIS inspector. 5 After a restricted organism has been cleared for importation at the port of entry, the organism can only be transported by a bonded commercial carrier immediately and directly...

  2. 30 CFR 75.326 - Mean entry air velocity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Mean entry air velocity. 75.326 Section 75.326... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.326 Mean entry air velocity. In exhausting face ventilation systems, the mean entry air velocity shall be at least 60 feet per...

  3. 31 CFR 357.0 - Book-entry systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Book-entry systems. 357.0 Section 357..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING BOOK-ENTRY TREASURY BONDS, NOTES AND BILLS HELD IN LEGACY TREASURY DIRECT General Information § 357.0 Book-entry systems. (a)...

  4. 31 CFR 337.6 - Conversions to book-entry.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Conversions to book-entry. 337.6... HOUSING ADMINISTRATION DEBENTURES Certificated Debentures § 337.6 Conversions to book-entry. Upon implementation of the book-entry debenture system, to be announced in advance by separate public notice, all...

  5. 19 CFR 141.18 - Entry by nonresident corporation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry by nonresident corporation. 141.18 Section....18 Entry by nonresident corporation. A nonresident corporation (i.e., one which is not incorporated... entry is located who is authorized to accept service of process against that corporation or, in the...

  6. 30 CFR 75.326 - Mean entry air velocity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... concentrations in accordance with the applicable levels. Mean entry air velocity shall be determined at or near... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Mean entry air velocity. 75.326 Section 75.326... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.326 Mean entry air velocity....

  7. 30 CFR 75.326 - Mean entry air velocity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... concentrations in accordance with the applicable levels. Mean entry air velocity shall be determined at or near... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Mean entry air velocity. 75.326 Section 75.326... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.326 Mean entry air velocity....

  8. 30 CFR 75.326 - Mean entry air velocity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... concentrations in accordance with the applicable levels. Mean entry air velocity shall be determined at or near... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Mean entry air velocity. 75.326 Section 75.326... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.326 Mean entry air velocity....

  9. 30 CFR 75.326 - Mean entry air velocity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... concentrations in accordance with the applicable levels. Mean entry air velocity shall be determined at or near... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Mean entry air velocity. 75.326 Section 75.326... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.326 Mean entry air velocity....

  10. 46 CFR 78.37-10 - Official log entries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 3 2014-10-01 2014-10-01 false Official log entries. 78.37-10 Section 78.37-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Logbook Entries § 78.37-10 Official log entries. (a) In addition to other items required to be entered in the...

  11. 46 CFR 78.37-10 - Official log entries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Official log entries. 78.37-10 Section 78.37-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Logbook Entries § 78.37-10 Official log entries. (a) In addition to other items required to be entered in the...

  12. Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis.

    PubMed

    Jackson, A; Carrara, P; Duke, V; Sinclair, P; Papaioannou, M; Harrison, C J; Foroni, L

    2000-06-01

    Two distinct regions of minimal deletion (RMD) have been identified at 6q25-q27 in non-Hodgkin's lymphoma (RMD-1), and at 6q21-q23 in acute lymphoblastic leukemia (ALL; RMD-2) by loss of heterozygosity and fluorescence in situ hybridization studies. In this study, 30 overlapping yeast artificial chromosomes (YACs), 1 expressed sequence tag, and 11 novel YAC ends were identified using bidirectional YAC walks between markers D6S447 (proximal) and D6S246 (distal) in RMD-2. The genes AF6q21, human homologue of the Drosophila tailless (HTLX), CD24 antigen, the Kruppel-like zinc finger BLIMP1, and cyclin C (CCNC), previously mapped to 6q21, were accurately positioned in a telomere-to-centromere orientation. Approximately 3.5 Mb were found to separate the BLIMP1 (adjacent to D6S447) and AF6q21 genes (telomeric to D6S246). Deletions of 6q were investigated in 21 cases of ALL using the newly characterized YAC clones in dual-color fluorescence in situ hybridization studies. A region centromeric to D6S447 (containing marker D6S283) and a region telomeric to marker CHLC.GGAT16CO2 (and containing marker D6S268) were identified as distinct and nonoverlapping regions of deletion in ALL.

  13. Summary analysis of the Gemini entry aerodynamics

    NASA Technical Reports Server (NTRS)

    Whitnah, A. M.; Howes, D. B.

    1972-01-01

    The aerodynamic data that were derived in 1967 from the analysis of flight-generated data for the Gemini entry module are presented. These data represent the aerodynamic characteristics exhibited by the vehicle during the entry portion of Gemini 2, 3, 5, 8, 10, 11, and 12 missions. For the Gemini, 5, 8, 10, 11, and 12 missions, the flight-generated lift-to-drag ratios and corresponding angles of attack are compared with the wind tunnel data. These comparisons show that the flight generated lift-to-drag ratios are consistently lower than were anticipated from the tunnel data. Numerous data uncertainties are cited that provide an insight into the problems that are related to an analysis of flight data developed from instrumentation systems, the primary functions of which are other than the evaluation of flight aerodynamic performance.

  14. Lunar Entry Downmode Options for Orion

    NASA Technical Reports Server (NTRS)

    Smith, Kelly M.; Rea, Jeremy

    2016-01-01

    For Exploration Missions 1 and 2, the Orion capsules will be entering the Earth's atmosphere with speeds in excess of 11 km/s. In the event of a degraded Guidance, Navigation, and Control system, attempting the nominal guided entry may be inadvisable due to the potential for failures that result in a loss of vehicle (or crew, when crew are aboard). In such a case, a method of assuring Earth capture, water landing, and observence of trajectory constraints (heating, loads) is desired. Such a method should also be robust to large state uncertainty and variations in entry interface states. This document will explore four approaches evaluated and their performance in ensuring a safe return of the Orion capsule in the event of onboard system degradation.

  15. Orion Exploration Mission Entry Interface Target Line

    NASA Technical Reports Server (NTRS)

    Rea, Jeremy R.

    2016-01-01

    The Orion Multi-Purpose Crew Vehicle is required to return to the continental United States at any time during the month. In addition, it is required to provide a survivable entry from a wide range of trans-lunar abort trajectories. The Entry Interface (EI) state must be targeted to ensure that all requirements are met for all possible return scenarios, even in the event of no communication with the Mission Control Center to provide an updated EI target. The challenge then is to functionalize an EI state constraint manifold that can be used in the on-board targeting algorithm, as well as the ground-based trajectory optimization programs. This paper presents the techniques used to define the EI constraint manifold and to functionalize it as a set of polynomials in several dimensions.

  16. Electroosmotic Entry Flow with Joule Heating Effects

    NASA Astrophysics Data System (ADS)

    Prabhakaran, Rama; Kale, Akshay; Xuan, Xiangchun

    Electrokinetic flow, which transports liquids by electroosmosis and samples by electrophoresis, is the transport method of choice in microfluidic chips over traditional pressure-driven flows. Studies on electrokinetic flows have so far been almost entirely limited to inside microchannels. Very little work has been done on the electroosmotic fluid entry from a reservoir to a microchannel, which is the origin of all fluid and sample motions in microchips. We demonstrate in this talk that strong vortices of opposite circulating directions can be generated in electroosmotic entry flows. We also develop a two-dimensional depth-averaged numerical model of the entire microchip to predict and understand the fluid temperature and flow fields at the reservoir-microchannel junction.

  17. Forty Meters from Entry to Victoria Crater

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view is presented as a cylindrical projection with geometric seam correction.

  18. Concepts of papillomavirus entry into host cells.

    PubMed

    Day, Patricia M; Schelhaas, Mario

    2014-02-01

    Papillomaviruses enter basal cells of stratified epithelia. Assembly of new virions occurs in infected cells during terminal differentiation. This unique biology is reflected in the mechanism of entry. Extracellularly, the interaction of nonenveloped capsids with several host cell proteins, after binding, results in discrete conformational changes. Asynchronous internalization occurs over several hours by an endocytic mechanism related to, but distinct from macropinocytosis. Intracellular trafficking leads virions through the endosomal system, and from late endosomes to the trans-Golgi-network, before nuclear delivery. Here, we discuss the existing data with the aim to synthesize an integrated model of the stepwise process of entry, thereby highlighting key open questions. Additionally, we relate data from experiments with cultured cells to in vivo results.

  19. Tactile Data Entry for Extravehicular Activity

    NASA Technical Reports Server (NTRS)

    Adams, Richard J.; Olowin, Aaron B.; Hannaford, Blake; Sands, O Scott

    2012-01-01

    In the task-saturated environment of extravehicular activity (EVA), an astronaut's ability to leverage suit-integrated information systems is limited by a lack of options for data entry. In particular, bulky gloves inhibit the ability to interact with standard computing interfaces such as a mouse or keyboard. This paper presents the results of a preliminary investigation into a system that permits the space suit gloves themselves to be used as data entry devices. Hand motion tracking is combined with simple finger gesture recognition to enable use of a virtual keyboard, while tactile feedback provides touch-based context to the graphical user interface (GUI) and positive confirmation of keystroke events. In human subject trials, conducted with twenty participants using a prototype system, participants entered text significantly faster with tactile feedback than without (p = 0.02). The results support incorporation of vibrotactile information in a future system that will enable full touch typing and general mouse interactions using instrumented EVA gloves.

  20. Cell entry of hepatitis C virus

    SciTech Connect

    Bartosch, Birke . E-mail: Birke.Bartosch@ens-lyon.fr; Cosset, Francois-Loic . E-mail: Francois-Loic.Cosset@ens-lyon.fr

    2006-04-25

    Hepatitis C virus (HCV), an important human pathogen, is an enveloped, positive-stranded RNA virus classified in the hepacivirus genus of the Flaviviridae family. Cell attachment of flaviviruses generally leads to endocytosis of bound virions. Systems that support HCV replication and particle formation in vitro are emerging only now, 16 years after the discovery of the virus. Albeit this limitation, the route of HCV cell entry as well as 'capture' molecules involved in low-affinity interactions for the initial contact of HCV with target cells and potential high-affinity receptor candidates that may mediate HCV trafficking and fusion has been described. The objective of this review is to summarize the contribution of different HCV model systems to our current knowledge about structure of the HCV GPs E1 and E2 and their roles in cell entry comprising cell attachment, interactions with cellular receptors, endocytosis, and fusion.

  1. Determining the identifiability of DNA database entries.

    PubMed Central

    Malin, B.; Sweeney, L.

    2000-01-01

    CleanGene is a software program that helps determine the identifiability of sequenced DNA, independent of any explicit demographics or identifiers maintained with the DNA. The program computes the likelihood that the release of DNA database entries could be related to specific individuals that are the subjects of the data. The engine within CleanGene relies on publicly available health care data and on knowledge of particular diseases to help relate identified individuals to DNA entries. Over 20 diseases, ranging over ataxias, blood diseases, and sex-linked mutations are accounted for, with 98-100% of individuals found identifiable. We assume the genetic material is released in a linear sequencing format from an individual's genome. CleanGene and its related experiments are useful tools for any institution seeking to provide anonymous genetic material for research purposes. PMID:11079941

  2. Joule heating effects on electroosmotic entry flow.

    PubMed

    Prabhakaran, Rama Aravind; Zhou, Yilong; Patel, Saurin; Kale, Akshay; Song, Yongxin; Hu, Guoqing; Xuan, Xiangchun

    2017-03-01

    Electroosmotic flow is the transport method of choice in microfluidic devices over traditional pressure-driven flow. To date, however, studies on electroosmotic flow have been almost entirely limited to inside microchannels. This work presents the first experimental study of Joule heating effects on electroosmotic fluid entry from the inlet reservoir (i.e., the well that supplies fluids and samples) to the microchannel in a polymer-based microfluidic chip. Electrothermal fluid circulations are observed at the reservoir-microchannel junction, which grow in size and strength with the increasing alternating current to direct current voltage ratio. Moreover, a 2D depth-averaged numerical model is developed to understand the effects of Joule heating on fluid temperature and flow fields in electrokinetic microfluidic chips. This model overcomes the problems encountered in previous unrealistic 2D and costly 3D models, and is able to predict the observed electroosmotic entry flow patterns with a good agreement.

  3. Data entry and error embedding system

    NASA Technical Reports Server (NTRS)

    Woo, Jr., John (Inventor); Woo, Daniel N. (Inventor)

    1998-01-01

    A data entry and error embedding system in which, first, a document is bitmapped and recorded in a first memory. Then, it is displayed, and portions of it to be replicated by data entry are underlayed by a window, into which window replicated data is entered in location and size such that it is juxtaposed just below that which is replicated, enhancing the accuracy of replication. Second, with this format in place, selected portions of the replicated data are altered by the insertion of character or word substitutions, thus the embedding of errors. Finally, a proofreader would endeavor to correct the error embedded data and a record of his or her changes recorded. In this manner, the skill level of the proofreader and accuracy of the data are computed.

  4. 29 CFR 1610.20 - Deletion of exempted matters.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Deletion of exempted matters. 1610.20 Section 1610.20 Labor... Production or Disclosure Under 5 U.S.C. 552 § 1610.20 Deletion of exempted matters. Where requested records contain matters which are exempted under 5 U.S.C. 552(b) but which matters are reasonably segregable...

  5. 29 CFR 1610.20 - Deletion of exempted matters.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Deletion of exempted matters. 1610.20 Section 1610.20 Labor... Production or Disclosure Under 5 U.S.C. 552 § 1610.20 Deletion of exempted matters. Where requested records contain matters which are exempted under 5 U.S.C. 552(b) but which matters are reasonably segregable...

  6. Exon deletions of the phenylalanine hydroxylase gene in Italian hyperphenylalaninemics

    PubMed Central

    Calì, Francesco; Ruggeri, Giuseppa; Vinci, Mirella; Meli, Concetta; Carducci, Carla; Leuzzi, Vincenzo; Pozzessere, Simone; Schinocca, Pietro; Ragalmuto, Alda; Chiavetta, Valeria; Miccichè, Salvatore

    2010-01-01

    A consistent finding of many studies describing the spectrum of mutant phenylalanine hydroxylase (PAH) alleles underlying hyperphenylalaninemia is the impossibility of achieving a 100% mutation ascertainment rate using conventional gene-scanning methods. These methods include denaturing gradient gel electrophoresis (DGGE), denaturing high performance liquid chromatography (DHPLC), and direct sequencing. In recent years, it has been shown that a significant proportion of undetermined alleles consist of large deletions overlapping one or more exons. These deletions have been difficult to detect in compound heterozygotes using gene-scanning methods due to a masking effect of the non-deleted allele. To date, no systematic search has been carried out for such exon deletions in Italian patients with phenylketonuria or mild hyperphenylalaninemia. We used multiplex ligation- dependent probe amplification (MLPA), comparative multiplex dosage analysis (CMDA), and real-time PCR to search for both large deletions and duplications of the phenylalanine hydroxylase gene in Italian hyperphenylalaninemia patients. Four deletions removing different phenylalanine hydroxylase (PAH) gene exons were identified in 12 patients. Two of these deletions involving exons 4-5-6-7-8 (systematic name c.353-?_912 + ?del) and exon 6 (systematic name c.510-?_706 + ?del) have not been reported previously. In this study, we show that exon deletion of the PAH gene accounts for 1.7% of all mutant PAH alleles in Italian hyperphenylalaninemics. PMID:19946181

  7. 37 CFR 2.35 - Adding, deleting, or substituting bases.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Adding, deleting, or... OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.35 Adding... add, substitute or delete a basis, unless the applicant meets the requirements for...

  8. 37 CFR 2.35 - Adding, deleting, or substituting bases.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Adding, deleting, or... OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.35 Adding... add, substitute or delete a basis, unless the applicant meets the requirements for...

  9. 37 CFR 2.35 - Adding, deleting, or substituting bases.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Adding, deleting, or... OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.35 Adding... add, substitute or delete a basis, unless the applicant meets the requirements for...

  10. 37 CFR 2.35 - Adding, deleting, or substituting bases.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Adding, deleting, or... OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.35 Adding... add, substitute or delete a basis, unless the applicant meets the requirements for...

  11. 37 CFR 2.35 - Adding, deleting, or substituting bases.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Adding, deleting, or... OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.35 Adding... add, substitute or delete a basis, unless the applicant meets the requirements for...

  12. 75 FR 60739 - Procurement List; Additions and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List; Additions and Deletions AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Additions to and Deletions... will be furnished by nonprofit agencies employing persons who are blind or have other...

  13. Linguistic and Psychomotor Development in Children with Chromosome 14 Deletions

    ERIC Educational Resources Information Center

    Zampini, Laura; D'Odorico, Laura; Zanchi, Paola; Zollino, Marcella; Neri, Giovanni

    2012-01-01

    The present study focussed on a specific type of rare genetic condition: chromosome 14 deletions. Children with this genetic condition often show developmental delays and brain and neurological problems, although the type and severity of symptoms varies depending on the size and location of the deleted genetic material. The specific aim of the…

  14. A Note On Deletion Rules in Fast Speech.

    ERIC Educational Resources Information Center

    Hewlett, Nigel

    In fast speech, certain segments pronounced in careful speech may be deleted. Rules of a generative phonology have been used to account for fast speech forms. An alternative approach is suggested which views fast speech deletions as merely limiting cases of segment reduction, under conditions of increased tempo and/or casualness. To complement…

  15. 78 FR 20622 - Procurement List, Proposed Additions and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List, Proposed Additions and Deletions AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Proposed Additions to and... disabilities, and delete services previously provided by such agencies. Comments Must Be Received On or...

  16. 77 FR 12816 - Procurement List Proposed Addition and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List Proposed Addition and Deletions AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Proposed addition to and... disabilities and delete products previously furnished by such agencies. Comments Must Be Received On or...

  17. Towards earlier diagnosis of 22q11 deletions

    PubMed Central

    Tobias, E; Morrison, N; Whiteford, M; Tolmie, J

    1999-01-01

    Over a 7 year period, 551 patients were investigated for the presence of a chromosome 22q11 deletion by fluorescence in situ hybridisation. Analysis of the presenting features of the 67 individuals with this chromosome deletion permitted us to devise guidelines to facilitate early diagnosis.

 PMID:10569971

  18. Coexistence of 9p Deletion Syndrome and Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Günes, Serkan; Ekinci, Özalp; Ekinci, Nuran; Toros, Fevziye

    2017-01-01

    Deletion or duplication of the short arm of chromosome 9 may lead to a variety of clinical conditions including craniofacial and limb abnormalities, skeletal malformations, mental retardation, and autism spectrum disorder. Here, we present a case report of 5-year-old boy with 9p deletion syndrome and autism spectrum disorder.

  19. Multivariate Variable Deletion Methods: Don't Do Stepwise

    ERIC Educational Resources Information Center

    Kadhi, TauGamba

    2003-01-01

    This paper explains the theory and methodology behind the use of variable deletion in canonical correlational analysis (CCA). Both the Capraro and Capraro (2002) and the Cantrell (1997) data tables are evaluated and explained in order to clarify strategies utilized. Understanding of variable deletion strategies and their proper usages in a CCA…

  20. Using Topic Modeling and Text Embeddings to Predict Deleted Tweets

    SciTech Connect

    Potash, Peter J.; Bell, Eric B.; Harrison, Joshua J.

    2016-02-29

    Predictive models for tweet deletion have been a relatively unexplored area of Twitter-related computational research. We first approach the deletion of tweets as a spam detection problem, applying a small set of handcrafted features to improve upon the current state-of-the- art in predicting deleted tweets. Next, we apply our approach to a dataset of deleted tweets that better reflects the current deletion rate. Since tweets are deleted for reasons beyond just the presence of spam, we apply topic modeling and text embeddings in order to capture the semantic content of tweets that can lead to tweet deletion. Our goal is to create an effective model that has a low-dimensional feature space and is also language-independent. A lean model would be computationally advantageous processing high-volumes of Twitter data, which can reach 9,885 tweets per second. Our results show that a small set of spam-related features combined with word topics and character-level text embeddings provide the best f1 when trained with a random forest model. The highest precision of the deleted tweet class is achieved by a modification of paragraph2vec to capture author identity.

  1. N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function.

    PubMed

    Yashiroda, Hideki; Toda, Yousuke; Otsu, Saori; Takagi, Kenji; Mizushima, Tsunehiro; Murata, Shigeo

    2015-01-01

    The proteasome core particle (CP) is a conserved protease complex that is formed by the stacking of two outer α-rings and two inner β-rings. The α-ring is a heteroheptameric ring of subunits α1 to α7 and acts as a gate that restricts entry of substrate proteins into the catalytic cavity formed by the two abutting β-rings. The 31-kDa proteasome inhibitor (PI31) was originally identified as a protein that binds to the CP and inhibits CP activity in vitro, but accumulating evidence indicates that PI31 is required for physiological proteasome activity. To clarify the in vivo role of PI31, we examined the Saccharomyces cerevisiae PI31 ortholog Fub1. Fub1 was essential in a situation where the CP assembly chaperone Pba4 was deleted. The lethality of Δfub1 Δpba4 was suppressed by deletion of the N terminus of α7 (α7ΔN), which led to the partial activation of the CP. However, deletion of the N terminus of α3, which activates the CP more efficiently than α7ΔN by gate opening, did not suppress Δfub1 Δpba4 lethality. These results suggest that the α7 N terminus has a role in CP activation different from that of the α3 N terminus and that the role of Fub1 antagonizes a specific function of the α7 N terminus.

  2. Space X1 First Entry Sample

    NASA Technical Reports Server (NTRS)

    James, John T.

    2012-01-01

    One mini-grab sample container (m-GSC) was returned aboard Space X1 because of the importance of quickly knowing first-entry conditions in this new commercial module. This sample was analyzed alongside samples of the portable clean room (PCR) used in the Space X complex at KSC. The recoveries of C-13-acetone, fluorobenzene, and chlorobenzene from the GSCs averaged 130, 129, and 132 %, respectively.

  3. Hypersonic Flight Mechanics. [for atmospheric entry trajectories

    NASA Technical Reports Server (NTRS)

    Busemann, A.; Vinh, N. X.; Culp, R. D.

    1976-01-01

    The effects of aerodynamic forces on trajectories at orbital speeds are discussed in terms of atmospheric models. The assumptions for the model are spherical symmetry, nonrotating, and an exponential atmosphere. The equations of flight, and the performance in extra-atmospheric flight are discussed along with the return to the atmosphere, and the entry. Solutions of the exact equations using directly matched asymptotic expansions are presented.

  4. Rarefied Flows of Planetary Entry Capsules

    NASA Technical Reports Server (NTRS)

    Moss, James N.

    1997-01-01

    The impact of rarefaction on entry capsules and spacecraft aerothermodynamics is emphasized for various aeroassist missions. The capability of the direct simulation Monte Carlo (DSMC) method to simulate such flows is demonstrated through examples of validation studies and applications. Several space flight projects and ground-based experiments are reviewed for which rarefaction effects have significant effect on spacecraft performance or experimental measurements. This review clearly demonstrates the significant role that the DSMC method plays in characterizing such flows.

  5. Filter for interpretation of fragmentation during entry

    SciTech Connect

    Canavan, G.H.

    1997-10-01

    Objects that fragment cascade and decelerate abruptly, producing short, bright, signatures which can be used to estimate object diameter and speed. Other objects can be incorporated into a generalized fragmentation filter. This note summarizes the results of previous reports on the prediction and inversion of signatures from objects that radiate, ablate, and fragment during entry and uses them to produce models for the parameters of entering objects.

  6. Crew Exploration Vehicle (CEV) Skip Entry Trajectory

    DTIC Science & Technology

    2008-03-01

    stage reusable launch system . The first stage Launch Assist Platform (LAP) lifts the vehicle to an altitude from which the OV can reach its orbit... Orion Skip Entry Guidance Algorithms”, AIAA-2077-6424 10. NASA Exploration Systems Architecture Study (ESAS), November 2005 11. Vinh, N. X., and...Requirements for the Degree of Master of Science in Space Systems Emre Kaya, BS First Lieutenant, TuAF March 2008 APPROVED FOR PUBLIC

  7. The Pioneer Venus Orbiter entry phase

    NASA Technical Reports Server (NTRS)

    Strangeway, R. J.

    1993-01-01

    In October, 1992 the Pioneer Venus Orbiter entered the atmosphere of Venus, ending nearly 14 years of observations at Venus. Prior to the entry into the atmosphere and subsequent loss of the spacecraft careful management of spacecraft resources had allowed the acquisition of much low altitude data over the nightside of the planet. The long duration of the Pioneer Venus mission has enabled us to study the ionosphere and atmosphere of Venus under different levels of solar activity.

  8. Kinetics of virus entry by endocytosis

    NASA Astrophysics Data System (ADS)

    Zhdanov, Vladimir P.

    2015-04-01

    Entry of virions into the host cells is either endocytotic or fusogenic. In both cases, it occurs via reversible formation of numerous relatively weak bonds resulting in wrapping of a virion by the host membrane with subsequent membrane rupture or scission. The corresponding kinetic models are customarily focused on the formation of bonds and do not pay attention to the energetics of the whole process, which is crucially dependent, especially in the case of endocytosis, on deformation of actin filaments forming the cytoskeleton of the host cell. The kinetic model of endocytosis, proposed by the author, takes this factor into account and shows that the whole process can be divided into a rapid initial transient stage and a long steady-state stage. The entry occurs during the latter stage and can be described as a first-order reaction. Depending on the details of the dependence of the grand canonical potential on the number of bonds, the entry can be limited either by the interplay of bond formation and membrane rupture (or scission) or by reaching a maximum of this potential.

  9. Atmospheric entry heating of cosmic dust

    NASA Technical Reports Server (NTRS)

    Flynn, George J.

    1987-01-01

    A computer simulation of the atmospheric entry deceleration and heating for micrometeorites into a planetary atmosphere was developed. The results of this model were compared to an earlier model. The major difference between the extent of heating experienced in the two models results from an underestimation of the atmospheric density at altitudes above 130 km in the earlier model. Thus the earlier model systematically overestimates the peak temperature reached on atmospheric entry. The discrepancies are small for near vertical entry and/or high density particles, where little deceleration is experienced at high altitudes. For particles entering at grazing incidence and/or of low density the discrepancies are more pronounced. Gravitational enhancement, which is a function of geocentric velocity at the collection opportunity, was found to bias near Earth cosmic dust collections in favor of low velocity particles. The effect is to increase the proportion of low velocity dust, predominately from asteroids, in the stratospheric cosmic dust collections and on Earth orbiting spacecraft impact surfaces over its proportion in the interplanetary dust cloud.

  10. Cell entry by human pathogenic arenaviruses.

    PubMed

    Rojek, Jillian M; Kunz, Stefan

    2008-04-01

    The arenaviruses Lassa virus (LASV) in Africa and Machupo (MACV), Guanarito (GTOV) and Junin viruses (JUNV) in South America cause severe haemorrhagic fevers in humans with fatality rates of 15-35%. The present review focuses on the first steps of infection with human pathogenic arenaviruses, the interaction with their cellular receptor molecules and subsequent entry into the host cell. While similarities exist in genomic organization, structure and clinical disease caused by pathogenic Old World and New World arenaviruses these pathogens use different primary receptors. The Old World arenaviruses employ alpha-dystroglycan, a cellular receptor for proteins of the extracellular matrix, and the human pathogenic New World arenaviruses use the cellular cargo receptor transferrin receptor 1. While the New World arenavirus JUNV enters cells via clathrin-dependent endocytosis, evidence occurred for clathrin-independent entry of the prototypic Old World arenavirus lymphocytic choriomeningitis virus. Upon internalization, arenaviruses are delivered to the endosome, where pH-dependent membrane fusion is mediated by the envelope glycoprotein (GP). While arenavirus GPs share characteristics with class I fusion GPs of other enveloped viruses, unusual mechanistic features of GP-mediated membrane fusion have recently been discovered for arenaviruses with important implications for viral entry.

  11. Radon entry control in new house construction.

    PubMed

    Najafi, F T; Lalwani, L; Li, W G

    1995-07-01

    People exposed to high concentration levels of radon face an increased risk of developing lung cancer. The risk is directly proportional to the length and level of radon exposure. Because of health reasons, it is safer to build new houses with radon mitigation systems installed in slab-on-grade houses. However, the interrelationships between parameters and factors governing radon entry and control are highly complex. A study performed by the University of Florida has examined the effectiveness of different radon entry control approaches. The analysis was based on 47 houses from three research projects conducted by the University of Florida (14 houses), Florida Solar Energy Center (13 houses), and GEOMET Technologies (20 houses). The evaluation of the performance and effectiveness of improved floor slabs, space conditioning, and ventilating systems were analyzed. Statistical analyses of the interrelationship between various parameters were also performed. Study findings such as the important factors in reducing radon entry and the effectiveness of passive construction approach and active subslab depressurization systems are presented in this paper.

  12. Orion Entry, Descent, and Landing Simulation

    NASA Technical Reports Server (NTRS)

    Hoelscher, Brian R.

    2007-01-01

    The Orion Entry, Descent, and Landing simulation was created over the past two years to serve as the primary Crew Exploration Vehicle guidance, navigation, and control (GN&C) design and analysis tool at the National Aeronautics and Space Administration (NASA). The Advanced NASA Technology Architecture for Exploration Studies (ANTARES) simulation is a six degree-of-freedom tool with a unique design architecture which has a high level of flexibility. This paper describes the decision history and motivations that guided the creation of this simulation tool. The capabilities of the models within ANTARES are presented in detail. Special attention is given to features of the highly flexible GN&C architecture and the details of the implemented GN&C algorithms. ANTARES provides a foundation simulation for the Orion Project that has already been successfully used for requirements analysis, system definition analysis, and preliminary GN&C design analysis. ANTARES will find useful application in engineering analysis, mission operations, crew training, avionics-in-the-loop testing, etc. This paper focuses on the entry simulation aspect of ANTARES, which is part of a bigger simulation package supporting the entire mission profile of the Orion vehicle. The unique aspects of entry GN&C design are covered, including how the simulation is being used for Monte Carlo dispersion analysis and for support of linear stability analysis. Sample simulation output from ANTARES is presented in an appendix.

  13. Hood entry coefficients of compound exhaust hoods.

    PubMed

    Figueroa, Crescente E

    2011-12-01

    A traditional method for assessing the flow rate in ventilation systems is based on multiple readings of velocity or velocity pressure (VP) (usually 10 or 20 points) taken in ductwork sections located away from fittings (> seven × diameters of straight duct). This study seeks to eliminate the need for a multiple-point evaluation and replace it with a simplified method that requires only a single measurement of hood static pressure (SP(h)) taken at a more accessible location (< three × diameters of straight duct from the hood entry). The SP(h) method is widely used for the assessment of flow rate in simple hoods. However, industrial applications quite often use compound hoods that are regularly of the slot/plenum type. For these hoods, a "compound coefficient of entry" has not been published, which makes the use of the hood static pressure method unfeasible. This study proposes a model for the computation of a "compound coefficient of entry" and validates the use of this model to assess flow rate in two systems of well-defined geometry (multi-slotted/plenum and single-slotted/tapered or "fish-tail" types). When using a conservative value of the slot loss factor (1.78), the proposed model yielded an estimate of the volumetric flow rate within 10% of that provided by a more comprehensive method of assessment. The simplicity of the hood static pressure method makes it very desirable, even in the upper range of experimental error found in this study.

  14. Orion Entry Flight Control Stability and Performance

    NASA Technical Reports Server (NTRS)

    Strahan, Alan L.; Loe, Greg R.; Seiler, Pete

    2007-01-01

    The Orion Spacecraft will be required to perform entry and landing functions for both Low Earth Orbit (LEO) and Lunar return missions, utilizing only the Command Module (CM) with its unique systems and GN&C design. This paper presents the current CM Flight Control System (FCS) design to support entry and landing, with a focus on analyses that have supported its development to date. The CM FCS will have to provide for spacecraft stability and control while following guidance or manual commands during exo-atmospheric flight, after Service Module separation, translational powered flight required of the CM, atmospheric flight supporting both direct entry and skip trajectories down to drogue chute deploy, and during roll attitude reorientation just prior to touchdown. Various studies and analyses have been performed or are on-going supporting an overall FCS design with reasonably sized Reaction Control System (RCS) jets, that minimizes fuel usage, that provides appropriate command following but with reasonable stability and control margin. Results from these efforts to date are included, with particular attention on design issues that have emerged, such as the struggle to accommodate sub-sonic pitch and yaw control without using excessively large jets that could have a detrimental impact on vehicle weight. Apollo, with a similar shape, struggled with this issue as well. Outstanding CM FCS related design and analysis issues, planned for future effort, are also briefly be discussed.

  15. Growth patterns of patients with 1p36 deletion syndrome.

    PubMed

    Sangu, Noriko; Shimojima, Keiko; Shimada, Shino; Ando, Tomohiro; Yamamoto, Toshiyuki

    2014-05-01

    1p36 deletion syndrome is one of the most common subtelomeric deletion syndromes. Obesity is frequently observed in patients with this syndrome. Thus, it is important to evaluate the growth status of an individual patient. For this purpose, we accumulated recorded growth data from 44 patients with this syndrome and investigated the growth patterns of patients. Most of the patients showed weight parameters within normal limits, whereas a few of these patients showed intrauterine growth delay and microcephaly. The length of the patients after birth was under the 50th centile in most patients. Many patients showed poor weight gain after birth, and only two female patients were overweight. These findings indicate two different phenotypes of the 1p36 deletion syndrome. The overweight patients with 1p36 deletion started excessive weight gain after two years of life. This characteristic of the patients with 1p36 deletion syndrome is similar to Prader-Willi syndrome.

  16. Delineation of 14q32.3 deletion syndrome.

    PubMed

    Ortigas, A P; Stein, C K; Thomson, L L; Hoo, J J

    1997-06-01

    A patient with a 14q32.3 terminal band deletion and cat cry is reported. Review of four other 14q32.3 deletion cases suggests the possible presence of a recognisable 14q32.3 terminal deletion syndrome, which is characterised by (1) apparently postnatal onset of small head size in comparison to body size, (2) high forehead with lateral hypertrichosis, (3) epicanthic folds, (4) broad nasal bridge, (5) high arched palate, (6) single palmar crease, and (7) mild to moderate developmental delay. Although none of the above seven features in unique to this syndrome, and indeed are quite common in other chromosomal disorders or genetic syndromes, patients with a terminal 14q32.3 deletion do show a recognisable facial gestalt. Interestingly, unlike ring chromosome 14, the 14q32.3 terminal deletion has rarely been reported, possibly because it is harder to detect, and an optimal chromosome preparation is required for its identification.

  17. Molecular mimicry and clonal deletion: A fresh look.

    PubMed

    Rose, Noel R

    2015-06-21

    In this article, I trace the historic background of clonal deletion and molecular mimicry, two major pillars underlying our present understanding of autoimmunity and autoimmune disease. Clonal deletion originated as a critical element of the clonal selection theory of antibody formation in order to explain tolerance of self. If we did have complete clonal deletion, there would be major voids, the infamous "black holes", in our immune repertoire. For comprehensive, protective adaptive immunity, full deletion is necessarily a rare event. Molecular mimicry, the sharing of epitopes among self and non-self antigens, is extraordinary common and provides the evidence that complete deletion of self-reactive clones is rare. If molecular mimicry were not common, protective adaptive immunity could not be all-encompassing. By taking a fresh look at these two processes together we can envision their evolutionary basis and understand the need for regulatory devices to prevent molecular mimicry from progressing to autoimmune disease.

  18. Attenuation of monkeypox virus by deletion of genomic regions

    USGS Publications Warehouse

    Lopera, Juan G.; Falendysz, Elizabeth A.; Rocke, Tonie E.; Osorio, Jorge E.

    2015-01-01

    Monkeypox virus (MPXV) is an emerging pathogen from Africa that causes disease similar to smallpox. Two clades with different geographic distributions and virulence have been described. Here, we utilized bioinformatic tools to identify genomic regions in MPXV containing multiple virulence genes and explored their roles in pathogenicity; two selected regions were then deleted singularly or in combination. In vitro and in vivostudies indicated that these regions play a significant role in MPXV replication, tissue spread, and mortality in mice. Interestingly, while deletion of either region led to decreased virulence in mice, one region had no effect on in vitro replication. Deletion of both regions simultaneously also reduced cell culture replication and significantly increased the attenuation in vivo over either single deletion. Attenuated MPXV with genomic deletions present a safe and efficacious tool in the study of MPX pathogenesis and in the identification of genetic factors associated with virulence.

  19. 19 CFR 132.14 - Special permits for immediate delivery; entry of merchandise before presenting entry summary for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... merchandise before presenting entry summary for consumption; permits of delivery. 132.14 Section 132.14... merchandise before presenting entry summary for consumption; permits of delivery. (a) Effect of issuance of... documentation before the proper presentation of an entry summary for consumption, or a withdrawal...

  20. An address geocoding solution for Chinese cities

    NASA Astrophysics Data System (ADS)

    Zhang, Xuehu; Ma, Haoming; Li, Qi

    2006-10-01

    We introduce the challenges of address geocoding for Chinese cities and present a potential solution along with a prototype system that deal with these challenges by combining and extending current geocoding solutions developed for United States and Japan. The proposed solution starts by separating city addresses into "standard" addresses which meet a predefined address model and non-standard ones. The standard addresses are stored in a structured relational database in their normalized forms, while a selected portion of the non-standard addresses are stored as aliases to the standard addresses. An in-memory address index is then constructed from the address database and serves as the basis for real-time address matching. Test results were obtained from two trials conducted in the city Beijing. On average 80% matching rate were achieved. Possible improvements to the current design are also discussed.

  1. Science Rationale for Jupiter Entry Probe as Part of JIMO

    NASA Technical Reports Server (NTRS)

    Young, R. E.; Spilker, T. R.

    2003-01-01

    A Jupiter atmospheric entry probe as part of JIMO is a cost effective way to address fundamental science questions identified in the National Research Council Solar System Exploration Decadal Survey (SSEDS): New Frontiers in the Solar System, An Integrated Ex- ploration Strategy. Compared to either the cost of an entirely separate Jupiter mission, or the cost of JIMO itself, inclusion of such a probe on JIMO would be cost advantageous. The probe itself could be relatively simple, and could build on the Galileo Probe heritage. The SSEDS specifically identified the distribution of water across the Solar System as a Key Scientific Question. Correspondingly, knowing the water abun dance on Jupiter is fundamental to understanding almost every aspect of the evolution of the early solar nebula. The Galileo Probe obtained the abundance of several key elements in Jupiter's atmosphere, which data have already caused major rethinking of theories of how Jupiter formed and how the early solar nebula evolved. However, because of a combination of circumstances, the global abundance of the key element oxygen, in the form of water, was not obtained. Without knowledge of the jovian water abundance, further progress in understanding Solar System evolution and planet formation will be greatly inhibited. Therefore, quantifying jovian water abundance should be a goal of the very next mission to the jovian system. Such a measurement would be impossible via remote sensing from the JIMO orbiter because of the large distances the JIMO orbiter maintains from Jupiter. A Jupiter atmospheric entry probe as part of JIMO could achieve the fundamental water measurement. In order that a probe avoid repeating the Galileo probe's experience of failing to obtain the jovian water abundance, the probe should go deep, to at least 100 bars pressure. Probes to 100 bars have been accomplished many times in descending to the surface of Venus, and at 100 bars the temperature of the jovian atmosphere is 60

  2. Mesh-Based Entry Vehicle and Explosive Debris Re-Contact Probability Modeling

    NASA Technical Reports Server (NTRS)

    McPherson, Mark A.; Mendeck, Gavin F.

    2011-01-01

    The risk to a crewed vehicle arising from potential re-contact with fragments from an explosive breakup of any jettisoned spacecraft segments during entry has long sought to be quantified. However, great difficulty lies in efficiently capturing the potential locations of each fragment and their collective threat to the vehicle. The method presented in this paper addresses this problem by using a stochastic approach that discretizes simulated debris pieces into volumetric cells, and then assesses strike probabilities accordingly. Combining spatial debris density and relative velocity between the debris and the entry vehicle, the strike probability can be calculated from the integral of the debris flux inside each cell over time. Using this technique it is possible to assess the risk to an entry vehicle along an entire trajectory as it separates from the jettisoned segment. By decoupling the fragment trajectories from that of the entry vehicle, multiple potential separation maneuvers can then be evaluated rapidly to provide an assessment of the best strategy to mitigate the re-contact risk.

  3. 'Deletion rescue' by mitotic 11q uniparental disomy in a family with recurrence of 11q deletion Jacobsen syndrome.

    PubMed

    Johnson, J P; Haag, M; Beischel, L; McCann, C; Phillips, S; Tunby, M; Hansen, J; Schwanke, C; Reynolds, J F

    2014-04-01

    We describe a family with recurrent 11q23-qter deletion Jacobsen syndrome in two affected brothers, with unique mosaic deletion 'rescue' through development of uniparental disomy (UPD) in the mother and one of the brothers. Inheritance studies show that the deleted chromosome is of maternal origin in both boys, and microarray shows a break near the ASAM gene. Parental lymphocyte chromosomes were normal. However, the mother is homozygous in lymphocytes for all loci within the deleted region in her sons, and presumably has UPD for this region. In addition, she is mosaic for the 11q deletion seen in her sons at a level of 20-30% in skin fibroblasts. We hypothesize that one of her #11 chromosomes shows fragility, that breakage at 11q23 occurred with telomeric loss in some cells, but 'rescue' from the deletion occurred in most cells by the development of mitotic UPD. She apparently carries the 11q deletion in her germ line resulting in recurrence of the syndrome. The older son is mosaic for the 11q cell line (70-88%, remainder 46,XY), and segmental UPD11 'rescue' apparently also occurred in his cytogenetically normal cells. This is a novel phenomenon restoring disomy to an individual with a chromosomal deletion.

  4. Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1.

    PubMed

    Xu, Ningyong; Cioffi, Donna L; Alexeyev, Mikhail; Rich, Thomas C; Stevens, Troy

    2015-02-15

    Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC). Orai1 silencing increases sodium permeability and decreases membrane-associated calcium, although it is not known whether Orai1 is an important determinant of cytosolic sodium transitions. We test the hypothesis that, upon activation of store-operated calcium entry channels, Orai1 is a critical determinant of cytosolic sodium transitions. Activation of store-operated calcium entry channels transiently increased cytosolic calcium and sodium, characteristic of release from an intracellular store. The sodium response occurred more abruptly and returned to baseline more rapidly than did the transient calcium rise. Extracellular choline substitution for sodium did not inhibit the response, although 2-aminoethoxydiphenyl borate and YM-58483 reduced it by ∼50%. After this transient response, cytosolic sodium continued to increase due to influx through activated store-operated calcium entry channels. The magnitude of this sustained increase in cytosolic sodium was greater when experiments were conducted in low extracellular calcium and when Orai1 expression was silenced; these two interventions were not additive, suggesting a common mechanism. 2-Aminoethoxydiphenyl borate and YM-58483 inhibited the sustained increase in cytosolic sodium, only in the presence of Orai1. These studies demonstrate that sodium permeates activated store-operated calcium entry channels, resulting in an increase in cytosolic sodium; the magnitude of this response is determined by Orai1.

  5. Physician order entry of ultrasound examination with handheld wireless terminal

    NASA Astrophysics Data System (ADS)

    Matsuya, Shiro; Onogi, Yuzo; Shinohara, Nobuo; Yamaguchi, Izumi; Watanabe, Hiroki; Ohe, Kazuhiko; Yamaguchi, Kenichi; Niidome, Takuro; Oyama, Hiroshi

    2004-04-01

    Although our hospital has an electronic order entry system, physician order entries must be performed using one of a limited number of terminals which are located in places like nurse stations. Due to this limitation, the mobility of the ultrasound machine cannot be fully exploited if a physician wants to perform a mobile ultrasound examination far from an entry terminal. In addition, this situation increases the possibility that a physician will fail to issue a paper voucher of the examination. In an attempt to resolve these problems, we have developed a mobile physician order entry system that incorporates ultrasound machines equipped with handheld wireless terminals, which use the 802.11b standard and the bandwidth is 11 Mbps. This is an efficient way to order ultrasound examination entries because physicians can register entries at any location in a hospital ward. In addition, the proposed system is a reliable method by which to attach images upon ultrasound examination entry.

  6. Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene.

    PubMed

    Rinchik, E M; Carpenter, D A; Handel, M A

    1995-07-03

    Variability and complexity of phenotypes observed in microdeletion syndromes can be due to deletion of a single gene whose product participates in several aspects of development or can be due to the deletion of a number of tightly linked genes, each adding its own effect to the syndrome. The p6H deletion in mouse chromosome 7 presents a good model with which to address this question of multigene vs. single-gene pleiotropy. Mice homozygous for the p6H deletion are diluted in pigmentation, are smaller than their littermates, and manifest a nervous jerky-gait phenotype. Male homozygotes are sterile and exhibit profound abnormalities in spermiogenesis. By using N-ethyl-N-nitrosourea (EtNU) mutagenesis and a breeding protocol designed to recover recessive mutations expressed hemizygously opposite a large p-locus deletion, we have generated three noncomplementing mutations that map to the p6H deletion. Each of these EtNU-induced mutations has adverse effects on the size, nervous behavior, and progression of spermiogenesis that characterize p6H deletion homozygotes. Because EtNU is thought to induce primarily intragenic (point) mutations in mouse stem-cell spermatogonia, we propose that the trio of phenotypes (runtiness, nervous jerky gait, and male sterility) expressed in p6H deletion homozygotes is the result of deletion of a single highly pleiotropic gene. We also predict that a homologous single locus, quite possibly tightly linked and distal to the D15S12 (P) locus in human chromosome 15q11-q13, may be associated with similar developmental abnormalities in humans.

  7. Entry, Descent, and Landing Operations Analysis for the Stardust Re-Entry Capsule

    NASA Technical Reports Server (NTRS)

    Desao, Prasun N.; Lyons, Dan T.; Tooley, Jeff; Kangas, Julie

    2006-01-01

    On the morning of January 15, 2006, the Stardust capsule successfully landed at the Utah Test and Training range in northwest Utah returning cometary samples from the comet Wild-2. An overview of the entry, descent, and landing (EDL) trajectory analysis that was performed for targeting during the Stardust Mission Navigation Operations Phase upon final approach to Earth is described. In addition, how the predicted landing location and the resulting overall 99 percentile landing footprint ellipse obtained from a Monte Carlo analysis changed over the final days and hours prior to entry is also presented. The navigation and EDL operations effort accurately delivered the entry capsule to the desired landing site. The final landing location was 8.1 km from the target, which was well within the allowable landing area.

  8. Entry trajectory, entry environment, and analysis of spacecraft motion for the RAM C-3 flight experiment

    NASA Technical Reports Server (NTRS)

    Weaver, W. L.; Bowen, J. T.

    1972-01-01

    The RAM C-3 flight experiment was launched to study the problem of radiofrequency blackout at an entry velocity of 24,300 ft/sec. The flight is described, and data for the entry trajectory and environment, which include the effects of actual temperature measured the day of launch, are presented. An analysis of entry spacecraft motions was performed. This analysis included the determination of wind angles from measured accelerations and estimates of wind angles at high altitudes from gyro-measured rotation rates. The maximum wind angles were found to be less than 5 deg to the point of pitch-roll resonance where the total wind angle increased to 8.5 deg and the roll rate started decreasing. A plausible cause for the decrease in roll rate was shown to be a combination of trim angle and an offset center of gravity.

  9. Assessment of the ATV-1 Re-Entry Observation Campaign for Future Re-Entry Missions

    NASA Astrophysics Data System (ADS)

    Lips, T.; Lohle, S.; Marynowsky, T.; Rees, D.; Stenbeak-Nielsen, H. C.; Beks, M. L.; Hatton, J.

    2010-09-01

    This paper summarizes the midterm results of the currently ongoing ESA study “Assessment of the ATV-1 Reentry Observation Campaign for Future Re-entry Missions”. The primary objective of this study is to investigate the data obtained during a joint ESA/NASA airborne observation campaign of the destructive re-entry of ATV-1 Jules Verne which occurred on September 29, 2008. The presented results are focused on spectroscopic fragment characterization(material identification), frame-by-frame fragment tracking(manual and automatic) for various video recordings, 3D triangulation of the tracked fragments, and fragment propagation until complete demise or ground impact, including the actual size and location of the ATV-1 debris footprint. Fragment propagation analyses comprise also the derivation of aerodynamic fragment properties and potential delta velocities. These parameters are of high importance for the re-entry safety analysis for ATV-2 Johannes Kepler.

  10. Addressing EO-1 Spacecraft Pulsed Plasma Thruster EMI Concerns

    NASA Technical Reports Server (NTRS)

    Zakrzwski, C. M.; Davis, Mitch; Sarmiento, Charles; Bauer, Frank H. (Technical Monitor)

    2001-01-01

    The Pulsed Plasma Thruster (PPT) Experiment on the Earth Observing One (EO-1) spacecraft has been designed to demonstrate the capability of a new generation PPT to perform spacecraft attitude control. Results from PPT unit level radiated electromagnetic interference (EMI) tests led to concerns about potential interference problems with other spacecraft subsystems. Initial plans to address these concerns included firing the PPT at the spacecraft level both in atmosphere, with special ground support equipment. and in vacuum. During the spacecraft level tests, additional concerns where raised about potential harm to the Advanced Land Imager (ALI). The inadequacy of standard radiated emission test protocol to address pulsed electromagnetic discharges and the lack of resources required to perform compatibility tests between the PPT and an ALI test unit led to changes in the spacecraft level validation plan. An EMI shield box for the PPT was constructed and validated for spacecraft level ambient testing. Spacecraft level vacuum tests of the PPT were deleted. Implementation of the shield box allowed for successful spacecraft level testing of the PPT while eliminating any risk to the ALI. The ALI demonstration will precede the PPT demonstration to eliminate any possible risk of damage of ALI from PPT operation.

  11. 22q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basis

    PubMed Central

    Squarcione, Chiara; Torti, Maria Chiara; Di Fabio, Fabio; Biondi, Massimo

    2013-01-01

    The 22q11.2 deletion syndrome (22q11DS) is caused by an autosomal dominant microdeletion of chromosome 22 at the long arm (q) 11.2 band. The 22q11DS is among the most clinically variable syndromes, with more than 180 features related with the deletion, and is associated with an increased risk of psychiatric disorders, accounting for up to 1%–2% of schizophrenia cases. In recent years, several genes located on chromosome 22q11 have been linked to schizophrenia, including those encoding catechol-O-methyltransferase and proline dehydrogenase, and the interaction between these and other candidate genes in the deleted region is an important area of research. It has been suggested that haploinsufficiency of some genes within the 22q11.2 region may contribute to the characteristic psychiatric phenotype and cognitive functioning of schizophrenia. Moreover, an extensive literature on neuroimaging shows reductions of the volumes of both gray and white matter, and these findings suggest that this reduction may be predictive of increased risk of prodromal psychotic symptoms in 22q11DS patients. Experimental and standardized cognitive assessments alongside neuroimaging may be important to identify one or more endophenotypes of schizophrenia, as well as a predictive prodrome that can be preventively treated during childhood and adolescence. In this review, we summarize recent data about the 22q11DS, in particular those addressing the neuropsychiatric and cognitive phenotypes associated with the deletion, underlining the recent advances in the studies about the genetic architecture of the syndrome. PMID:24353423

  12. How to Get Entry-Level Employment at the Top 100 Advertising Agencies.

    ERIC Educational Resources Information Center

    Donnelly, William J.

    1994-01-01

    Reports on a survey which quantifies the entry-level market in top advertising agencies. Discusses employment projections, entry-level job distribution, source of entry-level employment, college degree of entry-level employees, academic major of entry-level employees, and entry-level assignments by major. Concludes that an advertising major is far…

  13. ``Black Holes" and Bacterial Pathogenicity: A Large Genomic Deletion that Enhances the Virulence of Shigella spp. and Enteroinvasive Escherichia coli

    NASA Astrophysics Data System (ADS)

    Maurelli, Anthony T.; Fernandez, Reinaldo E.; Bloch, Craig A.; Rode, Christopher K.; Fasano, Alessio

    1998-03-01

    Plasmids, bacteriophages, and pathogenicity islands are genomic additions that contribute to the evolution of bacterial pathogens. For example, Shigella spp., the causative agents of bacillary dysentery, differ from the closely related commensal Escherichia coli in the presence of a plasmid in Shigella that encodes virulence functions. However, pathogenic bacteria also may lack properties that are characteristic of nonpathogens. Lysine decarboxylate (LDC) activity is present in ≈ 90% of E. coli strains but is uniformly absent in Shigella strains. When the gene for LDC, cadA, was introduced into Shigella flexneri 2a, virulence became attenuated, and enterotoxin activity was inhibited greatly. The enterotoxin inhibitor was identified as cadaverine, a product of the reaction catalyzed by LDC. Comparison of the S. flexneri 2a and laboratory E. coli K-12 genomes in the region of cadA revealed a large deletion in Shigella. Representative strains of Shigella spp. and enteroinvasive E. coli displayed similar deletions of cadA. Our results suggest that, as Shigella spp. evolved from E. coli to become pathogens, they not only acquired virulence genes on a plasmid but also shed genes via deletions. The formation of these ``black holes,'' deletions of genes that are detrimental to a pathogenic lifestyle, provides an evolutionary pathway that enables a pathogen to enhance virulence. Furthermore, the demonstration that cadaverine can inhibit enterotoxin activity may lead to more general models about toxin activity or entry into cells and suggests an avenue for antitoxin therapy. Thus, understanding the role of black holes in pathogen evolution may yield clues to new treatments of infectious diseases.

  14. "Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli.

    PubMed

    Maurelli, A T; Fernández, R E; Bloch, C A; Rode, C K; Fasano, A

    1998-03-31

    Plasmids, bacteriophages, and pathogenicity islands are genomic additions that contribute to the evolution of bacterial pathogens. For example, Shigella spp., the causative agents of bacillary dysentery, differ from the closely related commensal Escherichia coli in the presence of a plasmid in Shigella that encodes virulence functions. However, pathogenic bacteria also may lack properties that are characteristic of nonpathogens. Lysine decarboxylase (LDC) activity is present in approximately 90% of E. coli strains but is uniformly absent in Shigella strains. When the gene for LDC, cadA, was introduced into Shigella flexneri 2a, virulence became attenuated, and enterotoxin activity was inhibited greatly. The enterotoxin inhibitor was identified as cadaverine, a product of the reaction catalyzed by LDC. Comparison of the S. flexneri 2a and laboratory E. coli K-12 genomes in the region of cadA revealed a large deletion in Shigella. Representative strains of Shigella spp. and enteroinvasive E. coli displayed similar deletions of cadA. Our results suggest that, as Shigella spp. evolved from E. coli to become pathogens, they not only acquired virulence genes on a plasmid but also shed genes via deletions. The formation of these "black holes," deletions of genes that are detrimental to a pathogenic lifestyle, provides an evolutionary pathway that enables a pathogen to enhance virulence. Furthermore, the demonstration that cadaverine can inhibit enterotoxin activity may lead to more general models about toxin activity or entry into cells and suggests an avenue for antitoxin therapy. Thus, understanding the role of black holes in pathogen evolution may yield clues to new treatments of infectious diseases.

  15. Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.

    PubMed

    Zhang, Yuening; Li, Muyan; Xiao, Feifan; Teng, Ruobing; Zhang, Chengdong; Lan, Aihua; Gu, Kailong; Li, Jiatong; Wang, Di; Li, Hongtao; Jiang, Li; Zeng, Siping; He, Min; Huang, Yi; Guo, Peifen; Zhang, Xinhua; Yang, Xiaoli

    2015-10-15

    This study aims to investigate the effect of the partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility through a comprehensive literature search. All case-control studies related to partial DAZ1/2 and DAZ3/4 deletions and male infertility risk were included in our study. Odd ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and its precision, respectively. Eleven partial DAZ1/2 deletion and nine partial DAZ3/4 deletion studies were included. Partial DAZ1/2 deletion was significantly associated with male infertility risk in the overall analysis (ORs=2.58, 95%CI: 1.60-4.18, I(2)=62.1%). Moreover, in the subgroup analysis stratified by ethnicity, partial DAZ1/2 deletion was significantly associated with male infertility risk in the East Asian populations under the random effect model (ORs=2.96, 95%CI: 1.87-4.71, I(2)=51.3%). Meanwhile, the analysis suggested that partial DAZ3/4 deletion was not associated with male infertility risk in East-Asian ethnicity (ORs=1.02, 95%CI: 0.54-1.92, I(2)=71.3%), but not in Non-East Asian under the random effect model (ORs=3.56, 95%CI: 1.13-11.23, I(2)=0.0%,). More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%). In our meta-analysis, partial DAZ1/2 deletion is a risk factor for male infertility and different ethnicities have different influences, whereas partial DAZ3/4 deletion has no effect on fertility but partial DAZ3/4 deletion might have an impact on Non-East Asian male.

  16. Gene deletion in urothelium by specific expression of Cre recombinase.

    PubMed

    Mo, Lan; Cheng, Jin; Lee, Eva Y-H P; Sun, Tung-Tien; Wu, Xue-Ru

    2005-09-01

    Urothelium that lines almost the entire urinary tract acts as a permeability barrier and is involved in the pathogenesis of major urinary diseases, including urothelial carcinoma, urinary tract infection, and interstitial cystitis. However, investigation of urothelial biology and diseases has been hampered by the lack of tissue-specific approaches. To address this deficiency, we sought to develop a urothelium-specific knockout system using the Cre/loxP strategy. Transgenic mouse lines were generated in which a 3.6-kb mouse uroplakin II (UPII) promoter was used to drive the expression of Cre recombinase (Cre). Among the multiple tissues analyzed, Cre was found to be expressed exclusively in the urothelia of the transgenic mice. Crossing a UPII-Cre transgenic line with a ROSA26-LacZ reporter line, in which LacZ expression depends on Cre-mediated deletion of a floxed "stop" sequence, led to LacZ expression only in the urothelium. Gene recombination was also observed when the UPII-Cre line was crossed to an independent line in which a part of the p53 gene was flanked by the loxP sequences (floxed p53). Truncation of the p53 gene and mRNA was observed exclusively in the urothelia of double transgenic mice harboring both the UPII-Cre transgene and the floxed p53 allele. These results demonstrate for the first time the feasibility and potentially wide applicability of the UPII-Cre transgenic mice to inactivate any genes of interest in the urothelium.

  17. 22q11.2 deletion syndrome

    PubMed Central

    McDonald-McGinn, Donna M.; Sullivan, Kathleen E.; Marino, Bruno; Philip, Nicole; Swillen, Ann; Vorstman, Jacob A. S.; Zackai, Elaine H.; Emanuel, Beverly S.; Vermeesch, Joris R.; Morrow, Bernice E.; Scambler, Peter J.; Bassett, Anne S.

    2016-01-01

    22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder, estimated to result mainly from de novo non-homologous meiotic recombination events occurring in approximately 1 in every 1,000 fetuses. The first description in the English language of the constellation of findings now known to be due to this chromosomal difference was made in the 1960s in children with DiGeorge syndrome, who presented with the clinical triad of immunodeficiency, hypoparathyroidism and congenital heart disease. The syndrome is now known to have a heterogeneous presentation that includes multiple additional congenital anomalies and later-onset conditions, such as palatal, gastrointestinal and renal abnormalities, autoimmune disease, variable cognitive delays, behavioural phenotypes and psychiatric illness — all far extending the original description of DiGeorge syndrome. Management requires a multidisciplinary approach involving paediatrics, general medicine, surgery, psychiatry, psychology, interventional therapies (physical, occupational, speech, language and behavioural) and genetic counselling. Although common, lack of recognition of the condition and/or lack of familiarity with genetic testing methods, together with the wide variability of clinical presentation, delays diagnosis. Early diagnosis, preferably prenatally or neonatally, could improve outcomes, thus stressing the importance of universal screening. Equally important, 22q11.2DS has become a model for understanding rare and frequent congenital anomalies, medical conditions, psychiatric and developmental disorders, and may provide a platform to better understand these disorders while affording opportunities for translational strategies across the lifespan for both patients with 22q11.2DS and those with these associated features in the general population. PMID:27189754

  18. Radiation Database for Earth and Mars Entry

    DTIC Science & Technology

    2008-11-17

    Htot = − 2∑ α=1 h2 8π2Mα ∇2α − Ne∑ i=1 h2 8π2me ∇2i + Vn,n + Vn,e + Ve,e + Hsf (38) were Mα is the mass of nucleus α and me the electron mass. The...nuclear-electron potential energy, the electron-electron potential energy. The last term Hsf includes the different terms linked to interaction of spin...and angular momenta leading to the fine structure: Hsf = HSO +HSS +HSR (39) Radiation Database for Earth and Mars Entry RTO-EN-AVT-162 8 - 9 HSO

  19. Evolved Acceleration Guidance for Planetary Entry

    NASA Astrophysics Data System (ADS)

    Mease, K. D.; Leavitt, J. A.; Ferch, M.

    The U.S. Apollo and Shuttle programs have proven the viability and effectiveness of acceleration guidance. New capabilities have been developed to augment this basic concept. Algorithms have been designed for low lift to drag ratio vehicles and for mid to high lift to drag ratio vehicles. These algorithms have been tested for Mars landing and for earth entry of reusable launch vehicles and have performed well in both cases. Also the trajectory planner has been incorporated into a landing footprint generator that is designed for on-board use.

  20. About Pascal's tetrahedron with hypercomplex entries

    NASA Astrophysics Data System (ADS)

    Cruz, C.; Falcão, M. I.; Malonek, H. R.

    2013-10-01

    It is evident, that the properties of monogenic polynomials in (n + 1)-real variables significantly depend on the generators e1,e2,...,en of the underlying 2n-dimensional Clifford algebra Cℓ0,n over R and their interactions under multiplication. The case of n = 3 is studied through the consideration of Pascal's tetrahedron with hypercomplex entries as special case of the general Pascal simplex for arbitrary n, which represents a useful geometric arrangement of all possible products. The different layers Lk of Pascal's tetrahedron (or pyramid) are built by ordered symmetric products contained in the trinomial expansion of (e1+e2+e3)k,k = 0,1,....

  1. Anatomy of an entry vehicle experiment

    NASA Technical Reports Server (NTRS)

    Eide, D. G.; Wurster, K. E.; Helms, V. T.; Ashby, G. C.

    1981-01-01

    The anatomy and evolution of a simple small-scale unmanned entry vehicle is described that is delivered to orbit by the shuttle and entered into the atmosphere from orbit to acquire flight data to improve our knowledge of boundary-layer behavior and evaluate advanced thermal protection systems. The anatomy of the experiment includes the justification for the experiments, instrumentation, configuration, material, and operational needs, and the translation of these needs into a configuration, weight statement, aerodynamics, program cost, and trajectory. Candidates for new instrumentation development are also identified for nonintrusive measurements of the boundary-layer properties.

  2. Distant entry pneumothorax in a competitive fencer.

    PubMed Central

    Harmer, P A; Moriarity, J; Walsh, M; Bean, M; Cramer, J

    1996-01-01

    An elite level fencer sustained a penetrating wound to the upper arm after his opponent's blade broke. Standard care for a deep puncture wound was given but it was some time before the athlete presented symptoms of a pneumothorax, which was confirmed by radiograph. Although resolution of this case was unremarkable, the possibility of penetrating thoracic injury, even when the point of entry is well outside the thorax and the athlete is not immediately symptomatic, should be born in mind by medical personnel working with fencers. Images Figure 1 Figure 2 PMID:8889127

  3. Distant entry pneumothorax in a competitive fencer.

    PubMed

    Harmer, P A; Moriarity, J; Walsh, M; Bean, M; Cramer, J

    1996-09-01

    An elite level fencer sustained a penetrating wound to the upper arm after his opponent's blade broke. Standard care for a deep puncture wound was given but it was some time before the athlete presented symptoms of a pneumothorax, which was confirmed by radiograph. Although resolution of this case was unremarkable, the possibility of penetrating thoracic injury, even when the point of entry is well outside the thorax and the athlete is not immediately symptomatic, should be born in mind by medical personnel working with fencers.

  4. 16 CFR 0.2 - Official address.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Official address. The principal office of the Commission is at Washington, DC. All communications to the Commission should be addressed to the Federal Trade Commission, 600 Pennsylvania Avenue, NW, Washington,...

  5. 16 CFR 0.2 - Official address.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Official address. The principal office of the Commission is at Washington, DC. All communications to the Commission should be addressed to the Federal Trade Commission, 600 Pennsylvania Avenue, NW, Washington,...

  6. 16 CFR 0.2 - Official address.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Official address. The principal office of the Commission is at Washington, DC. All communications to the Commission should be addressed to the Federal Trade Commission, 600 Pennsylvania Avenue, NW, Washington,...

  7. Why is entry exclusion an essential feature of conjugative plasmids?

    PubMed

    Garcillán-Barcia, M Pilar; de la Cruz, Fernando

    2008-07-01

    Entry exclusion is a property of plasmids by which the cells that contain them become bad recipients in additional conjugation rounds. This work reviews entry exclusion essential features and analyzes the mechanisms of action of the best studied systems. We searched for homologs of the proteins responsible for experimentally known exclusion systems. Results were used to classify exclusion systems in families of related elements. We arrive to the conclusion that all conjugative plasmids contain at least one entry exclusion gene. Although entry exclusion genes seem to be part of the plasmid conjugative machinery, they are systematically absent in phylogenetically related type IV protein exporting machines involved in virulence for plants and animals. We infer from this fact that entry exclusion is an essential feature of conjugative plasmid biology. Mathematical models suggest that plasmids expressing entry exclusion selectively eliminate plasmids lacking it, reinforcing its essential character and suggesting that entry exclusion plays a direct role in plasmid survival. Other experimental results confirm that entry exclusion is essential for the stability of a conjugative plasmid. We suggest that entry exclusion limits the damage of lethal zygosis (bacterial death produced by excessive rounds of conjugation). Additionally, it avoids competition in a host among identical plasmid backbones. Conversely, the lack of entry exclusion in conjugative transposons can be understood as a means of generating rapid evolutionary change.

  8. Drug patent expirations and the speed of generic entry.

    PubMed Central

    Bae, J P

    1997-01-01

    OBJECTIVE: Using recent data, to analyze the generic drug entry phenomenon to determine the factors that influence the speed and likelihood of generic drug entries. DATA SOURCES: Data for 81 drugs that have lost patent between 1987 and 1994. Patent and exclusive marketing rights expiration dates: Food and Drug Administration's (FDA) Approved Drug Products with Therapeutic Equivalent Evaluations (1986-1989). Generic entry dates: FDA Drug and Device Product Approvals (Jan. 1987-Dec. 1994). Numbers of pending generic applications: FDA Office of Generic Drugs Quantitative Report-ANDAs and AADAs (Nov. 1990-Jan. 1993). Sales revenue: Pharmaceutical Data Services, Walsh-America. STUDY DESIGN: This study appropriately recognizes generic entry as a survival problem, and uses a proportional hazard method for analysis. PRINCIPAL FINDINGS: (1) There is a negative relationship between an innovative drug's sales revenue and the time to generic entry. (2) Entries of generics tend to be slower for drugs that have either very few or a very large number of competing brands in the marketplace. (3) The time to generic entry increased overall between 1987 and 1994. (4) Drugs that primarily treat chronic symptoms tend to enter faster than the types of drugs that primarily treat acute illnesses. CONCLUSIONS: The analysis shows that the generic industry is targeting large-revenue products and chronic drug markets. Entry of a generic drug is influenced by the existing branded substitutes in the marketplace. Surprisingly, the generic drug entry process has slowed despite many changes that would facilitate entry. PMID:9108806

  9. Attenuated Response to Methamphetamine Sensitization and Deficits in Motor Learning and Memory after Selective Deletion of [beta]-Catenin in Dopamine Neurons

    ERIC Educational Resources Information Center

    Diaz-Ruiz, Oscar; Zhang, YaJun; Shan, Lufei; Malik, Nasir; Hoffman, Alexander F.; Ladenheim, Bruce; Cadet, Jean Lud; Lupica, Carl R.; Tagliaferro, Adriana; Brusco, Alicia; Backman, Cristina M.

    2012-01-01

    In the present study, we analyzed mice with a targeted deletion of [beta]-catenin in DA neurons (DA-[beta]cat KO mice) to address the functional significance of this molecule in the shaping of synaptic responses associated with motor learning and following exposure to drugs of abuse. Relative to controls, DA-[beta]cat KO mice showed significant…

  10. Entry, Descent, and Landing with Propulsive Deceleration: Supersonic Retropropulsion Wind Tunnel Testing and Shock Phenomena

    NASA Technical Reports Server (NTRS)

    Palaszewski, Bryan

    2014-01-01

    The future exploration of the Solar System will require innovations in transportation and the use of entry, descent, and landing (EDL) systems at many planetary landing sites. The cost of space missions has always been prohibitive, and using the natural planetary and planet's moon atmospheres for entry, and descent can reduce the cost, mass, and complexity of these missions. This paper will describe some of the EDL ideas for planetary entry and survey the overall technologies for EDL that may be attractive for future Solar System missions. Future EDL systems may include an inflatable decelerator for the initial atmospheric entry and an additional supersonic retropropulsion (SRP) rocket system for the final soft landing. A three engine retropropulsion configuration with a 2.5 in. diameter sphere-cone aeroshell model was tested in the NASA Glenn Research Center's 1- by 1-ft (1×1) Supersonic Wind Tunnel (SWT). The testing was conducted to identify potential blockage issues in the tunnel, and visualize the rocket flow and shock interactions during supersonic and hypersonic entry conditions. Earlier experimental testing of a 70deg Viking-like (sphere-cone) aeroshell was conducted as a baseline for testing of a SRP system. This baseline testing defined the flow field around the aeroshell and from this comparative baseline data, retropropulsion options will be assessed. Images and analyses from the SWT testing with 300- and 500-psia rocket engine chamber pressures are presented here. In addition, special topics of electromagnetic interference with retropropulsion induced shock waves and retropropulsion for Earth launched booster recovery are also addressed.

  11. Entry, Descent, and Landing with Propulsive Deceleration: Supersonic Retropropulsion Wind Tunnel Testing and Shock Phenomena

    NASA Technical Reports Server (NTRS)

    Palaszewski, Bryan

    2013-01-01

    The future exploration of the Solar System will require innovations in transportation and the use of entry, descent, and landing (EDL) systems at many planetary landing sites. The cost of space missions has always been prohibitive, and using the natural planetary and planet's moon atmospheres for entry, and descent can reduce the cost, mass, and complexity of these missions. This paper will describe some of the EDL ideas for planetary entry and survey the overall technologies for EDL that may be attractive for future Solar System missions. Future EDL systems may include an inflatable decelerator for the initial atmospheric entry and an additional supersonic retro-propulsion (SRP) rocket system for the final soft landing. A three engine retro-propulsion configuration with a 2.5 inch diameter sphere-cone aeroshell model was tested in the NASA Glenn 1x1 Supersonic Wind Tunnel (SWT). The testing was conducted to identify potential blockage issues in the tunnel, and visualize the rocket flow and shock interactions during supersonic and hypersonic entry conditions. Earlier experimental testing of a 70 degree Viking-like (sphere-cone) aeroshell was conducted as a baseline for testing of a supersonic retro-propulsion system. This baseline testing defined the flow field around the aeroshell and from this comparative baseline data, retro-propulsion options will be assessed. Images and analyses from the SWT testing with 300- and 500-psia rocket engine chamber pressures are presented here. In addition, special topics of electromagnetic interference with retro-propulsion induced shock waves and retro-propulsion for Earth launched booster recovery are also addressed.

  12. 47 CFR 97.23 - Mailing address.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Mailing address. 97.23 Section 97.23 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO... name and mailing address. The mailing address must be in an area where the amateur service is...

  13. 47 CFR 97.23 - Mailing address.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Mailing address. 97.23 Section 97.23 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO... name and mailing address. The mailing address must be in an area where the amateur service is...

  14. 47 CFR 97.23 - Mailing address.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Mailing address. 97.23 Section 97.23 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO... name and mailing address. The mailing address must be in an area where the amateur service is...

  15. 47 CFR 97.23 - Mailing address.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Mailing address. 97.23 Section 97.23 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO... name and mailing address. The mailing address must be in an area where the amateur service is...

  16. 47 CFR 97.23 - Mailing address.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Mailing address. 97.23 Section 97.23 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AMATEUR RADIO... name and mailing address. The mailing address must be in an area where the amateur service is...

  17. 37 CFR 41.10 - Correspondence addresses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Correspondence addresses. 41... Correspondence addresses. Except as the Board may otherwise direct, (a) Appeals. Correspondence in an application... correspondence in an application or a patent involved in an appeal to the Board for which an address is...

  18. 37 CFR 41.10 - Correspondence addresses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Correspondence addresses. 41... Correspondence addresses. Except as the Board may otherwise direct, (a) Appeals. Correspondence in an application... correspondence in an application or a patent involved in an appeal to the Board for which an address is...

  19. 47 CFR 13.10 - Licensee address.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Licensee address. 13.10 Section 13.10 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.10 Licensee address. In accordance with § 1.923 of this chapter all applications must specify an address where...

  20. 32 CFR 516.7 - Mailing addresses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Mailing addresses. 516.7 Section 516.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION General § 516.7 Mailing addresses. Mailing addresses for organizations referenced...