Science.gov

Sample records for address future challenges

  1. Oral health in Libya: addressing the future challenges.

    PubMed

    Peeran, Syed Wali; Altaher, Omar Basheer; Peeran, Syed Ali; Alsaid, Fatma Mojtaba; Mugrabi, Marei Hamed; Ahmed, Aisha Mojtaba; Grain, Abdulgader

    2014-01-01

    Libya is a vast country situated in North Africa, having a relatively better functioning economy with a scanty population. This article is the first known attempt to review the current state of oral health care in Libya and to explore the present trends and future challenges. Libyan health system, oral health care, and human resources with the present status of dental education are reviewed comprehensively. A bibliographic study of oral health research and publications has been carried out. The results point toward a common indicator that oral health-related research is low. Strategies have to be developed to educate the medical and dental professionals, to update the current curriculum and enable the system to be competent in all aspects of oral health care management. PMID:24666627

  2. Oral health in Libya: addressing the future challenges

    PubMed Central

    Peeran, Syed Wali; Altaher, Omar Basheer; Peeran, Syed Ali; Alsaid, Fatma Mojtaba; Mugrabi, Marei Hamed; Ahmed, Aisha Mojtaba; Grain, Abdulgader

    2014-01-01

    Libya is a vast country situated in North Africa, having a relatively better functioning economy with a scanty population. This article is the first known attempt to review the current state of oral health care in Libya and to explore the present trends and future challenges. Libyan health system, oral health care, and human resources with the present status of dental education are reviewed comprehensively. A bibliographic study of oral health research and publications has been carried out. The results point toward a common indicator that oral health–related research is low. Strategies have to be developed to educate the medical and dental professionals, to update the current curriculum and enable the system to be competent in all aspects of oral health care management. PMID:24666627

  3. [Addressing intimate partner violence in substance-abuse treatment programmes: a challenge for the future].

    PubMed

    Fernández-Montalvo, Javier; López-Goñi, José Javier

    2011-01-01

    There is a close relationship between substance abuse (alcohol and other drugs) and intimate partner violence. Studies carried out with male offenders and with addicted patients show a high comorbidity rate between these two phenomena. However, few batterer intervention programmes have been implemented to date in the field of drug addiction. This paper proposes, first, the need to detect cases of intimate partner violence that are camouflaged beneath a drug problem. Thus, it is important to determine the prevalence rate of intimate partner aggressors among users of drug-addiction treatment programmes, as well as identifying the specific characteristics of these patients. Second, once aggressors are identified, it would be possible to develop specific programmes for the simultaneous treatment of the two problems (addiction and intimate partner violence). Some studies have already been carried with joint treatments for addiction and intimate partner violence. The results obtained are encouraging, and show that intervention programs with addictions can be a useful framework for applying also, where necessary, specific treatments for those addicted patients with an associated problem of intimate partner violence. Finally, implications for clinical practice and future research in this field are discussed. PMID:21503558

  4. Addressing the workforce pipeline challenge

    SciTech Connect

    Leonard Bond; Kevin Kostelnik; Richard Holman

    2006-11-01

    A secure and affordable energy supply is essential for achieving U.S. national security, in continuing U.S. prosperity and in laying the foundations to enable future economic growth. To meet this goal the next generation energy workforce in the U.S., in particular those needed to support instrumentation, controls and advanced operations and maintenance, is a critical element. The workforce is aging and a new workforce pipeline, to support both current generation and new build has yet to be established. The paper reviews the challenges and some actions being taken to address this need.

  5. 2010 Community College Futures Assembly Focus: Effective Leadership-Addressing the Graduation Challenge in the 21st Century

    ERIC Educational Resources Information Center

    Campbell, Dale F.; Yu, Hongwei

    2010-01-01

    The Community College Futures Assembly has served as a national independent policy think tank since 1995. Its purpose is to articulate the critical issues facing American community colleges and recognize innovative programs. Convening annually in January in Orlando, Florida, the Assembly provides an interactive learning environment where tough…

  6. Addressing Global Data Sharing Challenges.

    PubMed

    Alter, George C; Vardigan, Mary

    2015-07-01

    This issue of the Journal of Empirical Research on Human Research Ethics highlights the ethical issues that arise when researchers conducting projects in low- and middle-income countries seek to share the data they produce. Although sharing data is considered a best practice, the barriers to doing so are considerable and there is a need for guidance and examples. To that end, the authors of this article reviewed the articles in this special issue to identify challenges common to the five countries and to offer some practical advice to assist researchers in navigating this "uncharted territory," as some termed it. Concerns around informed consent, data management, data dissemination, and validation of research contributions were cited frequently as particularly challenging areas, so the authors focused on these four topics with the goal of providing specific resources to consult as well as examples of successful projects attempting to solve many of the problems raised. PMID:26297753

  7. Addressing Global Data Sharing Challenges

    PubMed Central

    Alter, George C.

    2015-01-01

    This issue of the Journal of Empirical Research on Human Research Ethics highlights the ethical issues that arise when researchers conducting projects in low- and middle-income countries seek to share the data they produce. Although sharing data is considered a best practice, the barriers to doing so are considerable and there is a need for guidance and examples. To that end, the authors of this article reviewed the articles in this special issue to identify challenges common to the five countries and to offer some practical advice to assist researchers in navigating this “uncharted territory,” as some termed it. Concerns around informed consent, data management, data dissemination, and validation of research contributions were cited frequently as particularly challenging areas, so the authors focused on these four topics with the goal of providing specific resources to consult as well as examples of successful projects attempting to solve many of the problems raised. PMID:26297753

  8. Applying evolutionary biology to address global challenges

    PubMed Central

    Carroll, Scott P.; Jørgensen, Peter Søgaard; Kinnison, Michael T.; Bergstrom, Carl T.; Denison, R. Ford; Gluckman, Peter; Smith, Thomas B.; Strauss, Sharon Y.; Tabashnik, Bruce E.

    2014-01-01

    Two categories of evolutionary challenges result from escalating human impacts on the planet. The first arises from cancers, pathogens and pests that evolve too quickly, and the second from the inability of many valued species to adapt quickly enough. Applied evolutionary biology provides a suite of strategies to address these global challenges that threaten human health, food security, and biodiversity. This review highlights both progress and gaps in genetic, developmental and environmental manipulations across the life sciences that either target the rate and direction of evolution, or reduce the mismatch between organisms and human-altered environments. Increased development and application of these underused tools will be vital in meeting current and future targets for sustainable development. PMID:25213376

  9. Applying evolutionary biology to address global challenges.

    PubMed

    Carroll, Scott P; Jørgensen, Peter Søgaard; Kinnison, Michael T; Bergstrom, Carl T; Denison, R Ford; Gluckman, Peter; Smith, Thomas B; Strauss, Sharon Y; Tabashnik, Bruce E

    2014-10-17

    Two categories of evolutionary challenges result from escalating human impacts on the planet. The first arises from cancers, pathogens, and pests that evolve too quickly and the second, from the inability of many valued species to adapt quickly enough. Applied evolutionary biology provides a suite of strategies to address these global challenges that threaten human health, food security, and biodiversity. This Review highlights both progress and gaps in genetic, developmental, and environmental manipulations across the life sciences that either target the rate and direction of evolution or reduce the mismatch between organisms and human-altered environments. Increased development and application of these underused tools will be vital in meeting current and future targets for sustainable development. PMID:25213376

  10. GEOSS: Addressing Big Data Challenges

    NASA Astrophysics Data System (ADS)

    Nativi, S.; Craglia, M.; Ochiai, O.

    2014-12-01

    In the sector of Earth Observation, the explosion of data is due to many factors including: new satellite constellations, the increased capabilities of sensor technologies, social media, crowdsourcing, and the need for multidisciplinary and collaborative research to face Global Changes. In this area, there are many expectations and concerns about Big Data. Vendors have attempted to use this term for their commercial purposes. It is necessary to understand whether Big Data is a radical shift or an incremental change for the existing digital infrastructures. This presentation tries to explore and discuss the impact of Big Data challenges and new capabilities on the Global Earth Observation System of Systems (GEOSS) and particularly on its common digital infrastructure called GCI. GEOSS is a global and flexible network of content providers allowing decision makers to access an extraordinary range of data and information at their desk. The impact of the Big Data dimensionalities (commonly known as 'V' axes: volume, variety, velocity, veracity, visualization) on GEOSS is discussed. The main solutions and experimentation developed by GEOSS along these axes are introduced and analyzed. GEOSS is a pioneering framework for global and multidisciplinary data sharing in the Earth Observation realm; its experience on Big Data is valuable for the many lessons learned.

  11. The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations.

    PubMed

    Roe, Matthew T; Mahaffey, Kenneth W; Ezekowitz, Justin A; Alexander, John H; Goodman, Shaun G; Hernandez, Adrian; Temple, Tracy; Berdan, Lisa; Califf, Robert M; Harrington, Robert A; Peterson, Eric D; Armstrong, Paul W

    2015-06-01

    Recent developments have highlighted the challenges facing cardiovascular clinical research in global contemporary practice, particularly in North America, including shifting priorities for drug development targets, increasing regulatory requirements, and expensive operational approaches for conducting randomized clinical trials. Nonetheless, emerging trends such as the consolidation of practices and hospitals into integrated health systems, the integration of electronic health records from thousands of practices into large data repositories to support prospective research studies, and streamlined operational approaches such as registry-based trials and risk-based monitoring have created numerous opportunities to disrupt the clinical research paradigm. Within this context, academic research organizations around the globe, particularly a strengthened collaboration of 3 established academic research organizations in North America, are uniquely positioned to promote and develop grassroots collaborations across all types of clinical practices, to delineate successful solutions to obstacles that limit clinical research initiatives, and to guide the future of cardiovascular research in the global research environment. PMID:26027610

  12. Future challenges in renal transplantation.

    PubMed

    Whalen, H; Clancy, M; Jardine, A

    2012-02-01

    There is a worldwide increase in the incidence of end-stage renal disease. Renal transplantation has been shown to be cost effective, prolong survival and provide a better quality of life in comparison to dialysis. Consequently, there has been a steady increase in demand for organs leading to a shortage of available kidneys, and an increase in transplant waiting lists. Renal transplantation is therefore an expanding field with a number of unique future challenges to address. This article outlines strategies that may be employed to expand organ supply in order to meet increased demand. The ethical issues surrounding this are also summarized. Furthermore, we highlight techniques with the potential to minimize peri-transplant injury to the kidney on its journey from donor to recipient. Current and potential future management strategies to optimize graft and patient survival are also discussed. PMID:22361673

  13. The Achilles Heel of Future Economic Growth: The Workforce Development Challenge. What Is It? How Critical Is It? Who's Doing What To Address It?

    ERIC Educational Resources Information Center

    Waits, Mary Jo; Vandegrift, Judith A.

    Arizona businesses are facing a dearth of skilled workers. The work force deficit is about quantity and about quality. It is both an immediate problem and a long-term problem. It is a threat to business competitiveness and Arizona's competitive advantage, and it challenges both industry and government to find solutions. Currently the State of…

  14. Challenge for future agriculture

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Future food security will be dependent upon a combination of the stresses imposed by climate change, variability of weather within the growing season, development of cultivars more suited to different conditions, and the ability to develop effective adaptation strategies which allow these cultivars ...

  15. Addressing the challenges of emerging infectious disease.

    PubMed

    Pinner, R W

    1996-01-01

    Through the recent examples of diphtheria in the former Soviet Union, plague in India, and trends in pneumonia mortality in the United States, the author, in this article, illustrates issues in emerging infectious diseases. The Centers for Disease Control's plan, Addressing Emerging Infectious Disease Threats: A Prevention Strategy for the United States, is summarized. Initial efforts to implement this plan are described, with particular focus on the development of Emerging Infections Programs, which are conducting epidemiologic and laboratory projects on several infectious diseases, including invasive bacterial diseases, unexplained deaths, foodborne diseases, and ehrlichiosis in four population-based sites in the United States. PMID:8571983

  16. Advanced Cyberinfrastructure Investments Addressing Earth Science Challenges

    NASA Astrophysics Data System (ADS)

    Walton, A. L.; Spengler, S. J.; Zanzerkia, E. E.

    2014-12-01

    The National Science Foundation supports infrastructure development and research into Big Data challenges as part of its long-term cyberinfrastructure strategy. This strategy highlights the critical need to leverage and partner with other agencies, resources and service providers to the U.S. research community. The current cyberinfrastructure and research activities within NSF support advanced technology development, pilot demonstrations of new capabilities for the scientific community in general, and integration and interoperability of data resources across the Geoscience community. These activities include the Data Infrastructure Building Blocks, Big Data and EarthCube programs, among others. Investments are competitively solicited; the resulting portfolio of high performance computing, advanced information systems, new software capabilities, analytics and modeling supports a range of science disciplines. This presentation provides an overview of these research programs, highlighting some of the key investments in advanced analytics, coupled modeling, and seamless collaboration. Examples related to the geosciences, computer-aided discovery and hypothesis generation are highlighted.

  17. Conclusion: challenges for the future.

    PubMed

    North, D W

    1993-12-01

    The title "Challenges for the Future" implies the challenge to summarize a very complex meeting. Of necessity, I will present a personal impression. My interest is in risk assessment, which I define as a process for summarizing science in support of decision making. Risk assessment is sometimes regarded as arcane numerology, a rigid process of computing risk numbers in which much available science is unused. I am a strong advocate for the broader definition of risk assessment. It is encouraging to learn how much science is becoming available for use in risk assessment for gasoline, its components, and alternative fuels. PMID:17539103

  18. Addressing an Uncertain Future Using Scenario Analysis

    SciTech Connect

    Siddiqui, Afzal S.; Marnay, Chris

    2006-12-15

    The Office of Energy Efficiency and Renewable Energy (EERE) has had a longstanding goal of introducing uncertainty into the analysis it routinely conducts in compliance with the Government Performance and Results Act (GPRA) and for strategic management purposes. The need to introduce some treatment of uncertainty arises both because it would be good general management practice, and because intuitively many of the technologies under development by EERE have a considerable advantage in an uncertain world. For example, an expected kWh output from a wind generator in a future year, which is not exposed to volatile and unpredictable fuel prices, should be truly worth more than an equivalent kWh from an alternative fossil fuel fired technology. Indeed, analysts have attempted to measure this value by comparing the prices observed in fixed-price natural gas contracts compared to ones in which buyers are exposed to market prices (see Bolinger, Wiser, and Golove and (2004)). In addition to the routine reasons for exploring uncertainty given above, the history of energy markets appears to have exhibited infrequent, but troubling, regime shifts, i.e., historic turning points at which the center of gravity or fundamental nature of the system appears to have abruptly shifted. Figure 1 below shows an estimate of how the history of natural gas fired generating costs has evolved over the last three decades. The costs shown incorporate both the well-head gas price and an estimate of how improving generation technology has gradually tended to lower costs. The purpose of this paper is to explore scenario analysis as a method for introducing uncertainty into EERE's forecasting in a manner consistent with the preceding observation. The two questions are how could it be done, and what is its academic basis, if any. Despite the interest in uncertainty methods, applying them poses some major hurdles because of the heavy reliance of EERE on forecasting tools that are deterministic in

  19. QCD: Challenges for the future

    SciTech Connect

    Burrows, P.; Dawson, S.; Orr, L.; Smith, W.H.

    1997-01-13

    Despite many experimental verifications of the correctness of our basic understanding of QCD, there remain numerous open questions in strong interaction physics and we focus on the role of future colliders in addressing these questions. We discuss possible advances in the measurement of {alpha}{sub s}, in the study of parton distribution functions, and in the understanding of low x physics at present colliders and potential new facilities. We also touch briefly on the role of spin physics in advancing our understanding of QCD.

  20. ADDRESSING ENVIRONMENTAL ENGINEERING CHALLENGES WITH COMPUTATIONAL FLUID DYNAMICS

    EPA Science Inventory

    This paper discusses the status and application of Computational Fluid Dynamics )CFD) models to address environmental engineering challenges for more detailed understanding of air pollutant source emissions, atmospheric dispersion and resulting human exposure. CFD simulations ...

  1. The future challenge for aeropropulsion

    NASA Technical Reports Server (NTRS)

    Rosen, Robert; Bowditch, David N.

    1992-01-01

    NASA's research in aeropropulsion is focused on improving the efficiency, capability, and environmental compatibility for all classes of future aircraft. The development of innovative concepts, and theoretical, experimental, and computational tools provide the knowledge base for continued propulsion system advances. Key enabling technologies include advances in internal fluid mechanics, structures, light-weight high-strength composite materials, and advanced sensors and controls. Recent emphasis has been on the development of advanced computational tools in internal fluid mechanics, structural mechanics, reacting flows, and computational chemistry. For subsonic transport applications, very high bypass ratio turbofans with increased engine pressure ratio are being investigated to increase fuel efficiency and reduce airport noise levels. In a joint supersonic cruise propulsion program with industry, the critical environmental concerns of emissions and community noise are being addressed. NASA is also providing key technologies for the National Aerospaceplane, and is studying propulsion systems that provide the capability for aircraft to accelerate to and cruise in the Mach 4-6 speed range. The combination of fundamental, component, and focused technology development underway at NASA will make possible dramatic advances in aeropropulsion efficiency and environmental compatibility for future aeronautical vehicles.

  2. Addressing Heart Failure Challenges through Illness-Informed Social Work.

    PubMed

    Hopp, Faith Pratt; Camp, Jessica K; Perry, Tam E

    2015-08-01

    This article describes the role of social workers in addressing the needs of people with heart failure. Although previous studies have explored the role of social workers in health care settings, few studies have addressed the challenges of specific chronic diseases such as heart failure. To address this gap in the literature, this study used qualitative interviews with health care social workers (n = 8) to obtain in-depth information about activities and challenges related to heart failure care. Findings suggest that health care social workers perceive heart failure as characterized by an uncertain illness trajectory, frequent hospitalizations, and difficulties accessing formal and informal care. These findings suggest the importance of what we term illness-informed social work, a practice that combines heart failure knowledge with social work competencies to address the complex psychosocial issues in heart failure care. PMID:26285359

  3. Presidential Address: Culture and the Future of Education Research

    ERIC Educational Resources Information Center

    Halse, Christine

    2013-01-01

    Recent changes in higher education have confronted education research with a conundrum: how our traditionally multidisciplinary field can refine itself as a unified discipline. In this address I sketch out what this conundrum may mean for education research, both substantively and methodologically, in the future. I propose that one starting point…

  4. Changes, Challenges, and the Future.

    ERIC Educational Resources Information Center

    Lawler, Patricia A.; King, Kathleen P.

    2003-01-01

    An integrative approach views professional development for adult educators as learner centered and transformative; it should address motivation and technology. A new vision of professional development reconceptualizes the process to include understanding of contexts, active learning, reflection, and dialogue. (SK)

  5. Conclusion: challenges for the future

    PubMed Central

    North, D. Warner

    1993-01-01

    The title “Challenges for the Future” implies the challenge to summarize a very complex meeting. Of necessity, I will present a personal impression. My interest is in risk assessment, which I define as a process for summarizing science in support of decision making. Risk assessment is sometimes regarded as arcane numerology, a rigid process of computing risk numbers in which much available science is unused. I am a strong advocate for the broader definition of risk assessment. It is encouraging to learn how much science is becoming available for use in risk assessment for gasoline, its components, and alternative fuels. PMID:17539103

  6. The Challenge of the Future

    NASA Technical Reports Server (NTRS)

    Boyer, Justiss

    2007-01-01

    The presentation will focus primarily on Marketing and Branding Forms organizations and groups who are interested in competing in the future. The seven slides that pertain to the Shuttle program briefly describe the Oribital Processing Facilities and other important facilities, how big the Shuttle is in comparison to a D-9, and engine information. I talk about my role in the program through the Forms Management program and then move into the Marketing and Branding portion.

  7. Challenges in Diabetes Care: Can Digital Health Help Address Them?

    PubMed

    Iyengar, Varun; Wolf, Alexander; Brown, Adam; Close, Kelly

    2016-07-01

    In Brief There is great enthusiasm for the potential of digital health solutions in medicine and diabetes to address key care challenges: patient and provider burden, lack of data to inform therapeutic decision-making, poor access to care, and costs. However, the field is still in its nascent days; many patients and providers do not currently engage with digital health tools, and for those who do, the burden is still often high. Over time, digital health has excellent potential to collect data more seamlessly, make collected data more useful, and drive better outcomes at lower costs in less time. But there is still much to prove. This review offers key background information on the current state of digital health in diabetes, six of the most promising digital health technologies and services, and the challenges that remain. PMID:27621530

  8. Addressing mental health challenges facing the "Next America": A call for culture change.

    PubMed

    McLeigh, Jill D; Melton, Gary B

    2015-09-01

    Provides an editorial addressing future mental health challenges. The articles in this issue highlight the need to create environments conducive to promoting the well-being of future generations. The articles build on symposia held by the American Orthopsychiatric Association in 2015, which focused on the effects on well-being of changing sociodemographics and labor market trends. Included in these pages are articles that lay out some of the challenges young people today face and strategies for helping them transition to adulthood successfully. PMID:26460709

  9. Addressing the challenges of thermal imaging for firefighting applications

    NASA Astrophysics Data System (ADS)

    Kostrzewa, Joseph; Meyer, William H.; Poe, George; Terre, William A.; Salapow, Thomas M.; Raimondi, John

    2003-09-01

    By providing visibility through smoke and absolute darkness, thermal imaging has the potential to radically improve the effectiveness and safety of the modern firefighter. Some of the roles of thermal imaging are assisting in detection of victims; navigating through dark, smoke-filled structures; detecting indications of imminent flash-over/roll-over; identifying and attacking the seat and extension of a fire; and surveying for lingering hot spots after a fire is nearly extinguished. In many respects, thermal imaging is ideally suited for these functions. However, firefighting applications present the infrared community some unique and challenging design constraints, not the least of which is an operating environment that is in some ways more harsh than most aerospace applications. While many previous papers have described the benefits of thermal imaging for firefighters, this paper describes several specific engineering challenges of this application. These include large ambient temperature range, rapidly changing scene dynamics, extreme demands on AGC, and large dynamic range requirements. This paper describes these and other challenges in detail and explains how they were addressed and overcome in the design of Evolution 5000, a state-of-the-art thermal imager designed and manufactured by Mine Safety Appliances (MSA) using Indigo System"s Omega miniature uncooled camera core.

  10. Connectivity and complex systems in geomorphology: addressing some key challenges

    NASA Astrophysics Data System (ADS)

    Pöppl, Ronald; Turnbull-Lloyd, Laura; Parsons, Anthony; Bracken, Louise; Keesstra, Saskia; Masselink, Rens

    2016-04-01

    "Connectivity thinking" and related concepts have a long history in geomorphology. Since the beginning of the 21st century connectivity research experienced a huge boom in geomorphology as geomorphologists started to develop new concepts on connectivity to better understand the complexity of geomorphic systems and system response to change. However, progress in the field of connectivity in geomorphology has mostly been developing in a parallel manner, resulting in a multiplicity of definitions, concepts and methodological approaches. Nevertheless, a set of common key challenges amongst the different connectivity concepts and approaches used to understand complex geomorphic systems are also evident. In the course of a theory think tank of the COST Action ES1306 (CONNECTEUR - Connecting European Connectivity Research) the following five different key challenges were detected (Turnbull et al., in prep.): (i) defining the fundamental unit, (ii) distinguishing between structural and functional boundaries, (iii) emergent behavior, (iv) memory effects, (v) measuring connectivity. In this presentation we will a) discuss how these key challenges are addressed and approached in connectivity research in geomorphology, b) evaluate ways in which cross-disciplinary advances may be made by exploring potential for a common toolbox approach to the study of connectivity.

  11. Protecting the confidentiality of interim data: addressing current challenges.

    PubMed

    Fleming, Thomas R

    2015-02-01

    There is compelling evidence supporting the importance of maintaining confidentiality of interim data in clinical trials designed to reliably address the benefit-to-risk profile of interventions. While this is widely recognized, creative approaches are needed to achieve this in challenging settings where interim data are released for regulatory review and action, even though the trial would be continued to address its primary hypothesis. An illustration is the recently emerging setting of cardiovascular safety trials in type 2 diabetes mellitus. At the first stage of such trials, if large relative increases in cardiovascular major morbidity/mortality can be ruled out, data can be released solely for the purpose of allowing regulatory decision making about marketing approval. The trial is then continued in the post-marketing setting to address the primary hypothesis regarding whether smaller relative increases can be ruled out. Active rather than passive approaches are needed to protect the integrity of cardiovascular safety trials. Given the importance to trial integrity of maintaining confidentiality of interim data such as the estimated relative effect on cardiovascular risk, a Data Access Plan should be in place in these trials to ensure such data are not revealed to study participants and their caregivers, investigators involved in trial conduct, the sponsor's management team, and the public, until trial completion. A Performance Standards Document also should be developed to pre-specify targeted and minimally acceptable levels for recruitment rate, best real-world achievable adherence, avoidance of cross-ins, and retention rate. This document should specify creative approaches for achieving these targets, oversight procedures during trial conduct to monitor performance levels, and actions to be taken if emerging data indicate minimally acceptable levels are not being reached. In settings where meaningful breaches in confidentiality have occurred, such

  12. The Nation's Physician Workforce and Future Challenges.

    PubMed

    Grover, Atul; Orlowski, Janis M; Erikson, Clese E

    2016-01-01

    There is much debate about the adequacy of the U.S. physician workforce and projections of its future size, distribution and composition. Beginning with 3 observations about the workforce we believe are largely not subject to dispute, we address the debate by providing an overview of the current state of the workforce and Graduate Medical Education in the United States; a brief history of both calls for graduate medical education reform since 1910 and the recent, intense debate about the reliability of workforce projections; and a discussion of the challenges to understanding the physician workforce. We draw 3 concluding observations: (1) Precisely because projections can be unpredictable in their impact on both physician workforce behavior and public policy development, policy makers need to devote more attention to workforce projections, not less. (2) More research devoted specifically to the workforce implications of delivery and payment reforms is strongly needed. (3) Such research must be pursued with a sense of urgency, given the rapid aging of the Baby Boom generation, which will put a disproportionate demand on the nation's physician workforce. PMID:26802753

  13. The Sustainable Hydrogen Economy: Addressing the Challenges Ahead

    NASA Astrophysics Data System (ADS)

    Turner, John A.

    2006-10-01

    It is rapidly becoming apparent that energy is one of the most important issues facing our world today; in fact, in today's society energy is as important as food and water. Humankind finds itself faced the challenge of how to continue to power society, particularly in the face of the rapidly growing economies of emerging nations like India and China, and yet answer questions of sustainability, energy security, geopolitics and global environment. One of the major issues facing America and most other countries in the world is how to supply a transportation fuel, an energy carrier to replace gasoline. Hydrogen as an energy carrier, primarily derived from water, can address issues of sustainability, environmental emissions and energy security. The ``Hydrogen Economy'' then is the production of hydrogen, its distribution and utilization as an energy carrier. While the vision of a hydrogen economy has been around for over 130 years, the most recent push to use hydrogen as an energy carrier came as part of a US Presidential Initiative, announced in the 2003 State of the Union Address. It is important that we consider hydrogen in tandem with other technologies as an alternative to the once-abundant hydrocarbon resources on which our society depends. This talk will introduce sustainable energy systems, including fuel cell technology and discuss the vision, the barriers and possible pathways for the production and implementation of hydrogen into the energy infrastructure.

  14. Interweaving Knowledge Resources to Address Complex Environmental Health Challenges

    PubMed Central

    Anderson, Beth Ellen; Suk, William A.

    2015-01-01

    Background Complex problems do not respect academic disciplinary boundaries. Environmental health research is complex and often moves beyond these boundaries, integrating diverse knowledge resources to solve such challenges. Here we describe an evolving paradigm for interweaving approaches that integrates widely diverse resources outside of traditional academic environments in full partnerships of mutual respect and understanding. We demonstrate that scientists, social scientists, and engineers can work with government agencies, industry, and communities to interweave their expertise into metaphorical knowledge fabrics to share understanding, resources, and enthusiasm. Objective Our goal is to acknowledge and validate how interweaving research approaches can contribute to research-driven, solution-oriented problem solving in environmental health, and to inspire more members of the environmental health community to consider this approach. Discussion The National Institutes of Health’s National Institute of Environmental Health Sciences Superfund Research Program (SRP), as mandated by Congress, has evolved to become a program that reaches across a wide range of knowledge resources. SRP fosters interweaving multiple knowledge resources to develop innovative multidirectional partnerships for research and training. Here we describe examples of how motivation, ideas, knowledge, and expertise from different people, institutions, and agencies can integrate to tackle challenges that can be as complex as the resources they bring to bear on it. Conclusions By providing structure for interweaving science with its stakeholders, we are better able to leverage resources, increase potential for innovation, and proactively ensure a more fully developed spectrum of beneficial outcomes of research investments. Citation Anderson BE, Naujokas MF, Suk WA. 2015. Interweaving knowledge resources to address complex environmental health challenges. Environ Health Perspect 123:1095–1099

  15. Addressing Earth Science Data Access Challenges through User Experience Research

    NASA Astrophysics Data System (ADS)

    Hemmings, S. N.; Banks, B.; Kendall, J.; Lee, C. M.; Irwin, D.; Toll, D. L.; Searby, N. D.

    2013-12-01

    The NASA Capacity Building Program (Earth Science Division, Applied Sciences Program) works to enhance end-user capabilities to employ Earth observation and Earth science (EO/ES) data in decision-making. Open data access and user-tailored data delivery strategies are critical elements towards this end. User Experience (UX) and User Interface (UI) research methods can offer important contributions towards addressing data access challenges, particularly at the interface of science application/product development and product transition to end-users. This presentation focuses on developing nation contexts and describes methods, results, and lessons learned from two recent UX/UI efforts conducted in collaboration with NASA: the SERVIRglobal.net redesign project and the U.S. Water Partnership (USWP) Portal development effort. SERVIR, a collaborative venture among NASA, USAID, and global partners, seeks to improve environmental management and climate change response by helping governments and other stakeholders integrate EO and geospatial technologies into decision-making. The USWP, a collaboration among U.S. public and private sectors, harnesses U.S.-based resources and expertise to address water challenges in developing nations. SERVIR's study, conducted from 2010-2012, assessed and tested user needs, preferences, and online experiences to generate a more user-friendly online data portal at SERVIRglobal.net. The portal provides a central access interface to data and products from SERVIR's network of hubs in East Africa, the Hindu Kush Himalayas, and Mesoamerica. The second study, conducted by the USWP Secretariat and funded by the U.S. Department of State, seeks to match U.S.-based water information resources with developing nation stakeholder needs. The USWP study utilizes a multi-pronged approach to identify key design requirements and to understand the existing water data portal landscape. Adopting UX methods allows data distributors to design customized UIs that

  16. Acquired resistance to immunotherapy and future challenges.

    PubMed

    Restifo, Nicholas P; Smyth, Mark J; Snyder, Alexandra

    2016-02-01

    Advances in immunotherapy have resulted in remarkable clinical responses in some patients. However, one of the biggest challenges in cancer therapeutics is the development of resistant disease and disease progression on or after therapy. Given that many patients have now received various types of immunotherapy, we asked three scientists to give their views on the current evidence for whether acquired resistance to immunotherapy exists in patients and the future challenges posed by immunotherapy. PMID:26822578

  17. Future technology challenges for failure analysis

    SciTech Connect

    Anderson, R.E.; Soden, J.M.; Henderson, C.L.

    1995-08-01

    Failure analysis is a critical element in the integrated circuit manufacturing industry. This paper explores the challenges for IC failure analysis in the environment of present and future silicon IC technology trends, using the 1994 National Technology Roadmap for Semiconductors as a technology guide. Advanced failure analysis techniques that meet the challenges of state-of-the-art IC technology are described and their applications are discussed. New paradigms will be required for failure analysis to keep pace with future advancements in IC technology.

  18. Opinion: Challenging the Future of Education's Discourse

    ERIC Educational Resources Information Center

    Wall, Steven D.

    2010-01-01

    In this article, the author reflects on Education Secretary Arne Duncan's speech at Teachers College, Columbia University, to an audience of pre-service teachers, their professors, graduate students, and others on the future needs of education. The author found that Mr. Duncan's speech did not suffice in addressing the depth of his subject.…

  19. CHALLENGES FOR THE FUTURE IN ENVIRONMENTAL MUTAGENESIS

    EPA Science Inventory

    CHALLENGES FOR THE FUTURE IN ENVIRONMENTAL MUTAGENESIS
    Michael D. Waters
    US Environmental Protection Agency, MD-51A, Research Triangle Park, NC 27711 USA

    Our rapidly growing understanding of the structure of the human genome is forming the basis for numerous new...

  20. IFE Chamber Technology - Status and Future Challenges

    SciTech Connect

    Meier, W R; Raffrary, A R; Abdel-Khalik, S; Kulcinski, G; Latkowski, J F; Najmabadi, F; Olson, C L; Peterson, P F; Ying, A; Yoda, M

    2002-11-15

    Significant progress has been made on addressing critical issues for inertial fusion energy (IFE) chambers for heavy-ion, laser and Z-pinch drivers. A variety of chamber concepts are being investigated including dry-wall (currently favored for laser IFE), wetted-wall (applicable to both laser and ion drivers), and thick-liquid-wall favored by heavy ion and z-pinch drivers. Recent progress and remaining challenges in developing IFE chambers are reviewed.

  1. Addressing statistical and operational challenges in designing large-scale stream condition surveys.

    PubMed

    Dobbie, Melissa J; Negus, Peter

    2013-09-01

    Implementing a statistically valid and practical monitoring design for large-scale stream condition monitoring and assessment programs can be difficult due to factors including the likely existence of a diversity of ecosystem types such as ephemeral streams over the sampling domain; limited resources to undertake detailed monitoring surveys and address knowledge gaps; and operational constraints on effective sampling at monitoring sites. In statistical speak, these issues translate to defining appropriate target populations and sampling units; designing appropriate spatial and temporal sample site selection methods; selection and use of appropriate indicators; and setting effect sizes with limited ecological and statistical information about the indicators of interest. We identify the statistical and operational challenges in designing large-scale stream condition surveys and discuss general approaches for addressing them. The ultimate aim in drawing attention to these challenges is to ensure operational practicality in carrying out future monitoring programs and that the resulting inferences about stream condition are statistically valid and relevant. PMID:23344628

  2. Some Future Software Engineering Opportunities and Challenges

    NASA Astrophysics Data System (ADS)

    Boehm, Barry

    This paper provides an update and extension of a 2006 paper, “Some Future Trends and Implications for Systems and Software Engineering Processes,” Systems Engineering, Spring 2006. Some of its challenges and opportunities are similar, such as the need to simultaneously achieve high levels of both agility and assurance. Others have emerged as increasingly important, such as the challenges of dealing with ultralarge volumes of data, with multicore chips, and with software as a service. The paper is organized around eight relatively surprise-free trends and two “wild cards” whose trends and implications are harder to foresee. The eight surprise-free trends are:

  3. Futures Challenges in Thyroid Hormone Signaling Research

    PubMed Central

    Flamant, Frédéric

    2016-01-01

    The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research. PMID:27445973

  4. Futures Challenges in Thyroid Hormone Signaling Research.

    PubMed

    Flamant, Frédéric

    2016-01-01

    The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research. PMID:27445973

  5. Online Learning: Addressing Challenges and Seizing Opportunities. Hawaii

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  6. Online Learning: Addressing Challenges and Seizing Opportunities. Oklahoma

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  7. Online Learning: Addressing Challenges and Seizing Opportunities. West Virginia

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  8. Online Learning: Addressing Challenges and Seizing Opportunities. Virginia

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  9. Online Learning: Addressing Challenges and Seizing Opportunities. Louisiana

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  10. Online Learning: Addressing Challenges and Seizing Opportunities. North Carolina

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  11. Online Learning: Addressing Challenges and Seizing Opportunities. Nevada

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  12. Online Learning: Addressing Challenges and Seizing Opportunities. New York

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  13. Online Learning: Addressing Challenges and Seizing Opportunities. Illinois

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  14. Online Learning: Addressing Challenges and Seizing Opportunities. South Carolina

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  15. Online Learning: Addressing Challenges and Seizing Opportunities. Wyoming

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  16. Online Learning: Addressing Challenges and Seizing Opportunities. North Dakota

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  17. Online Learning: Addressing Challenges and Seizing Opportunities. Maine

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  18. Online Learning: Addressing Challenges and Seizing Opportunities. New Hampshire

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  19. Online Learning: Addressing Challenges and Seizing Opportunities. Minnesota

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  20. Online Learning: Addressing Challenges and Seizing Opportunities. Kentucky

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  1. Online Learning: Addressing Challenges and Seizing Opportunities. Wisconsin

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  2. Online Learning: Addressing Challenges and Seizing Opportunities. Indiana

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  3. Online Learning: Addressing Challenges and Seizing Opportunities. Washington

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  4. Online Learning: Addressing Challenges and Seizing Opportunities. Arkansas

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  5. Online Learning: Addressing Challenges and Seizing Opportunities. Michigan

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  6. Online Learning: Addressing Challenges and Seizing Opportunities. Pennsylvania

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  7. Online Learning: Addressing Challenges and Seizing Opportunities. Vermont

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  8. Online Learning: Addressing Challenges and Seizing Opportunities. Kansas

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  9. Online Learning: Addressing Challenges and Seizing Opportunities. South Dakota

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  10. Online Learning: Addressing Challenges and Seizing Opportunities. Nebraska

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  11. Online Learning: Addressing Challenges and Seizing Opportunities. Georgia

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  12. Online Learning: Addressing Challenges and Seizing Opportunities. New Jersey

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  13. Online Learning: Addressing Challenges and Seizing Opportunities. Ohio

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  14. Online Learning: Addressing Challenges and Seizing Opportunities. Maryland

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  15. Online Learning: Addressing Challenges and Seizing Opportunities. Florida

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  16. Online Learning: Addressing Challenges and Seizing Opportunities. California

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  17. Online Learning: Addressing Challenges and Seizing Opportunities. Rhode Island

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  18. Online Learning: Addressing Challenges and Seizing Opportunities. Utah

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  19. Online Learning: Addressing Challenges and Seizing Opportunities. Idaho

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  20. Online Learning: Addressing Challenges and Seizing Opportunities. Mississippi

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  1. Online Learning: Addressing Challenges and Seizing Opportunities. Texas

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  2. Online Learning: Addressing Challenges and Seizing Opportunities. Alabama

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers; (2) significant financial shortfalls; and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  3. Online Learning: Addressing Challenges and Seizing Opportunities. Tennessee

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  4. Online Learning: Addressing Challenges and Seizing Opportunities. Oregon

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  5. Online Learning: Addressing Challenges and Seizing Opportunities. Montana

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  6. Online Learning: Addressing Challenges and Seizing Opportunities. Missouri

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  7. Online Learning: Addressing Challenges and Seizing Opportunities. Arizona

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  8. Online Learning: Addressing Challenges and Seizing Opportunities. Connecticut

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  9. Online Learning: Addressing Challenges and Seizing Opportunities. Delaware

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers; (2) significant financial shortfalls; and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  10. Online Learning: Addressing Challenges and Seizing Opportunities. Colorado

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers; (2) significant financial shortfalls; and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  11. Online Learning: Addressing Challenges and Seizing Opportunities. Alaska

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  12. Online Learning: Addressing Challenges and Seizing Opportunities. New Mexico

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  13. ADDRESSING ENVIRONMENTAL ENGINEERING CHALLENGES WITH COMPUTATIONAL FLUID DYNAMICS

    EPA Science Inventory

    In the field of environmental engineering, modeling tools are playing an ever larger role in addressing air quality issues, including source pollutant emissions, atmospheric dispersion and human exposure risks. More detailed modeling of environmental flows requires tools for c...

  14. Addressing Human System Risks to Future Space Exploration

    NASA Technical Reports Server (NTRS)

    Paloski, W. H.; Francisco, D. R.; Davis, J. R.

    2015-01-01

    NASA is contemplating future human exploration missions to destinations beyond low Earth orbit, including the Moon, deep-space asteroids, and Mars. While we have learned much about protecting crew health and performance during orbital space flight over the past half-century, the challenges of these future missions far exceed those within our current experience base. To ensure success in these missions, we have developed a Human System Risk Board (HSRB) to identify, quantify, and develop mitigation plans for the extraordinary risks associated with each potential mission scenario. The HSRB comprises research, technology, and operations experts in medicine, physiology, psychology, human factors, radiation, toxicology, microbiology, pharmacology, and food sciences. Methods: Owing to the wide range of potential mission characteristics, we first identified the hazards to human health and performance common to all exploration missions: altered gravity, isolation/confinement, increased radiation, distance from Earth, and hostile/closed environment. Each hazard leads to a set of risks to crew health and/or performance. For example the radiation hazard leads to risks of acute radiation syndrome, central nervous system dysfunction, soft tissue degeneration, and carcinogenesis. Some of these risks (e.g., acute radiation syndrome) could affect crew health or performance during the mission, while others (e.g., carcinogenesis) would more likely affect the crewmember well after the mission ends. We next defined a set of design reference missions (DRM) that would span the range of exploration missions currently under consideration. In addition to standard (6-month) and long-duration (1-year) missions in low Earth orbit (LEO), these DRM include deep space sortie missions of 1 month duration, lunar orbital and landing missions of 1 year duration, deep space journey and asteroid landing missions of 1 year duration, and Mars orbital and landing missions of 3 years duration. We then

  15. A Canadian Effort to Address Fractions Teaching and Learning Challenges

    ERIC Educational Resources Information Center

    Yearley, Shelley; Bruce, Catherine D.

    2014-01-01

    Teaching and learning fraction concepts provides challenges in primary schools all over the world. In this article, Shelley Yearley and Catherine Bruce describe a fractions-based research project conducted in Ontario, Canada.

  16. Addressing Competencies for the Future in the Professional Curriculum

    PubMed Central

    Kelley, Kristi W.; Hammer, Dana P.; Haines, Stuart T.; Marlowe, Karen F.

    2009-01-01

    This paper reviews the literature, analyzes current and future practice, develops a list of competencies necessary for future pharmacists, and provides recommendations to pharmacy's academic enterprise regarding curricula of the future. Curricula of the future will center around 3 functional roles for pharmacists: patient-centered care, population-based care, and systems management; and must also foster the development of 5 cross-cutting abilities in student pharmacists: professionalism, self-directed learning, leadership and advocacy, interprofessional collaboration, and cultural competency. Future curricula must be developed in an evidence-based manner, focus less on information storage and retrieval, engage student pharmacists in a variety of highly interactive learning experiences, and expand experiential learning opportunities throughout all years. PMID:20221349

  17. Addressing competencies for the future in the professional curriculum.

    PubMed

    Jungnickel, Paul W; Kelley, Kristi W; Hammer, Dana P; Haines, Stuart T; Marlowe, Karen F

    2009-12-17

    This paper reviews the literature, analyzes current and future practice, develops a list of competencies necessary for future pharmacists, and provides recommendations to pharmacy's academic enterprise regarding curricula of the future. Curricula of the future will center around 3 functional roles for pharmacists: patient-centered care, population-based care, and systems management; and must also foster the development of 5 cross-cutting abilities in student pharmacists: professionalism, self-directed learning, leadership and advocacy, interprofessional collaboration, and cultural competency. Future curricula must be developed in an evidence-based manner, focus less on information storage and retrieval, engage student pharmacists in a variety of highly interactive learning experiences, and expand experiential learning opportunities throughout all years. PMID:20221349

  18. Addressing future challenges for cancer services: part I.

    PubMed

    Maher, Jane; Radford, Gina

    2016-02-01

    Jane Maher & Gina Radford speak to Gemma Westcott, Commissioning Editor Jane Maher has been Macmillan's Chief Medical Officer since 1999 and now shares the role as Joint Chief Medical Officer with general practitioner Rosie Loftus, reflecting the growing need for specialists and generalists to work more effectively together. She has been a National Health Service (NHS) Improvement Clinical Leader for over 10 years and is a Consultant Clinical Oncologist at Mount Vernon Cancer Centre where she has worked for more than 20 years, during which she helped develop nonsurgical oncology services in five district general hospitals. Jane chaired the Maher Committee for the Department of Health in 1995, led the UK National Audit of Late Effects Pelvic Radiotherapy for the Royal College Of Radiologists (RCR) in 2000 and, most recently, chaired the 'National Cancer Survivorship Initiative, consequences of treatment work stream'. She co-founded one of the first Cancer Support and Information services in the UK, winning the Nye Bevan award in 1992 and there are now more than 60 units based on this model. She is a member of the Older People and Cancer Clinical Advisory Group. She has written more than 100 published articles and is a UK representative for cancer survivorship in Europe and advises on Cancer survivorship programs in Denmark and Canada. Gina Radford is Deputy Chief Medical Officer for England, a post she took up in January 2015. Prior to that, she has held a number of roles in public health, at local and regional level. Most recently she was as Centre Director for Anglia and Essex for Public Health England, and as part of that role helped lead nationally on the public health response to Ebola. She was until very recently Chair of one of the NICE public health advisory committees. She has previously worked on a number of national projects, including leading the Department of Health's response to the Shipman Enquiry, undertaking a review of specialist public health for CMO Scotland, chairing a national short life working group looking at the issue of making difficult decisions in NHS Scotland, and undertaking the evaluation of the first pilot (regional bowel cancer detection pilot) for the Be Clear on Cancer National Awareness and Early Diagnosis campaign, on behalf of the Department of Health and Cancer Research UK. Outside work, Gina is a Licensed Lay Minister in the Church of England, and is training to be ordained. She enjoys riding, walking the somewhat aging dog, reading and is the village duck warden! PMID:26846997

  19. Addressing future challenges for cancer services: part II.

    PubMed

    Maher, Jane; Radford, Gina

    2016-02-01

    Jane Maher & Gina Radford speak to Gemma Westcott, Commissioning Editor Jane Maher has been Macmillan's Chief Medical Officer since 1999 and now shares the role as Joint Chief Medical Officer with general practitioner Rosie Loftus, reflecting the growing need for specialists and generalists to work more effectively together. She has been an National Health Service (NHS) improvement clinical leader for over 10 years and is a Consultant Clinical Oncologist at Mount Vernon Cancer Centre and Hillingdon Hospital where she has worked for more than 20 years, during which she helped develop nonsurgical oncology services in five district general hospitals. She is a senior Clinical Lecturer at University College London and Visiting Professor in Cancer and Supportive Care at the Centre for Complexity Management at the University of Hertfordshire. Jane chaired the Maher Committee for the Department of Health in 1995, led the UK National Audit of Late Effects Pelvic Radiotherapy for the Royal College of Radiologists (RCR) in 2000 and, most recently, chaired the National Cancer Survivorship Initiative Consequences of Treatment work stream. She co-founded one of the first Cancer Support and Information services in the UK, winning the Nye Bevan award in 1992 and there are now more than 60 units based on this model. She is a member of the Older People and Cancer Clinical Advisory Group. She has written more than 100 published articles and is a UK representative for cancer survivorship in Europe and advises on cancer survivorship programs in Denmark and Canada. Gina Radford is Deputy Chief Medical Officer for England, a post she took up in January 2015. Prior to that, she has held a number of roles in public health, at local and regional level. Most recently she was Centre Director for Anglia and Essex for Public Health England, and as a part of that role helped lead nationally on the public health response to Ebola. She was until very recently Chair of one of the NICE public health advisory committees. She has previously worked on a number of national projects, including leading the Department of Health's response to the Shipman Enquiry, undertaking a review of specialist public health for CMO Scotland, chairing a national short life working group looking at the issue of making difficult decisions in NHS Scotland, and undertaking the evaluation of the first pilot (regional bowel cancer detection pilot) for the Be Clear on Cancer National Awareness and Early Diagnosis campaign, on behalf of the Department of Health and Cancer Research UK. Outside work, Gina is a Licensed Lay Minister in the Church of England, and is training to be ordained. She enjoys riding, walking the somewhat aging dog, reading and is the village duck warden! PMID:26846998

  20. Challenges in an Aging Society: Presidential Address to APPAM

    ERIC Educational Resources Information Center

    Swartz, Katherine

    2010-01-01

    The United States is at a critical crossroads in its history right now. The public policy problems that the people are facing are complex and interrelated, and the demographic changes that are about to significantly change their country are not well understood by large numbers of people. In this presidential address to the Association for Public…

  1. Keynote address: The past, present, and future of atomic time

    NASA Technical Reports Server (NTRS)

    Ramsey, Norman F.

    1990-01-01

    The early history of atomic time and frequency standards is reviewed. The most accurate and stable present standards are described. Prospective future improvements are discussed, particularly those with laser cooling and with trapped ions and atoms.

  2. Rehabilitation centers: marketing analysis and future challenges.

    PubMed

    Chandra, Ashish; Stroube, William B; Willis, William K

    2014-01-01

    A rehabilitation center is another form of health care organization that specializes in providing care for particular conditions of patients. Patients admitted in rehab centers range from being accident victims to those suffering with a specific illness. These organizations are becoming extremely valuable in providing patient care services. However, they have not marketed themselves as aggressively as other health care organizations. This article provides an insight regarding rehab centers and examines marketing issues using a SWOT (strengths, weaknesses, opportunities, and threats) analysis. It further provides some future prospects and challenges for marketers of these organizations. PMID:25405633

  3. Addressing Challenging Behavior: Considering the Logic of Probability

    ERIC Educational Resources Information Center

    Scott, Terrance M.; Hirn, Regina G.

    2014-01-01

    When dealing with children who exhibit challenging behaviors there are no known interventions that work for all students or at all times. Thus, intervention for these students is often implemented in a trial and error manner. This article provides a logic for considering probability as a factor in selecting strategies. Understanding that some…

  4. Addressing Strategic Challenges. Annual Report, 2001-2002.

    ERIC Educational Resources Information Center

    Council of Independent Colleges, Washington, DC.

    This report describes the activities of the Council of Independent Colleges (CIC) in 2001-2002. In that year, the CIC focused on implementing new programs, services, and initiatives based on the challenges identified in the previous year during the intensive strategic planning effort. Highlights for the year include: (1) new assistance to…

  5. Addressing Reticence: The Challenge of Engaging Reluctant Adult ESL Students

    ERIC Educational Resources Information Center

    Carter, Steven J.; Henrichsen, Lynn E.

    2015-01-01

    Reticence frequently prevents adult ESL learners from learning as much as they otherwise might. The nature of second-language learning requires frequent performance that may challenge students' self-concepts, leading to reticence and self-consciousness. To reduce or prevent this problem, teachers must employ appropriate pedagogical and classroom…

  6. Addressing a Nation's Challenge: Graduate Programs in Gerontology in Israel

    ERIC Educational Resources Information Center

    Carmel, Sara; Lowenstein, Ariela

    2007-01-01

    Like other developed nations, Israel has rapidly aged. This demographic revolution has created new challenges for Israeli society. We describe the societal background, including the emerging societal needs, solutions, and problems, as well as the professional principles, which guided us in developing the first two Israeli academic programs in…

  7. Identifying and Addressing Challenges to Research in University Laboratory Preschools

    ERIC Educational Resources Information Center

    File, Nancy

    2012-01-01

    Research Findings: This essay offers a review of challenges that university laboratory preschools face in providing a site for research that fits with other components of the program mission. An argument is made to consider paradigm shifts in research questions and methods that move away from traditions within the fields that study children's…

  8. Preventing and Addressing Challenging Behavior: Common Questions and Practical Strategies

    ERIC Educational Resources Information Center

    Hemmeter, Mary Louise; Ostrosky, Michaelene M.; Corso, Robert M.

    2012-01-01

    The purpose of this article is to offer preschool teachers strategies for preventing challenging behavior and supporting the development of social skills and emotional competencies. This article is framed in a question and answer format using questions from teachers who the authors have worked with in the past. These questions and strategies are…

  9. Powering nanorobotic devices: challenges and future strategies

    NASA Astrophysics Data System (ADS)

    Sankar, Krishna Moorthi

    2014-04-01

    Nanotechnology, even after 55 years since its foundation (1959 Richard Feynman's speech - `There is lot of space in the bottom'), is still in its infancy. However, of late, there has been a large increase in the research being done in this field in many prominent Universities and Research institutions across the globe. Nanorobotics is the combination of Nanotechnology and the science of Robotics, to create robots that are only a few nanometres (10-9 metres) in size. Nanobots are yet to be made. But with the current pace of ongoing researches, scientists predict that nanobots will be made a reality by next ten years. The main proposed function of nanobots is to use them in the medical field to interact with cells or intra-cellular substances and prevent or reverse structural and genetical problems and diseases. One of the major challenges faced while creating a nanobot to travel through human body is to power it. Nanobots would require a very small yet highly potential source of energy. There are many hypothesised energy sources for nanobots which are either already available within the human body naturally or which are to be supplied externally. But, all of these energy sources pose a few challenges which need to be addressed if they are to be used to power nanobots. These challenges can be overcome using a number of strategies that can be used to make an economically, ecologically and medically viable energy source.

  10. Scientists Weigh Society's Ability to Address Major Hydrological Challenges

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2014-05-01

    The prognosis is mixed about society's ability to deal successfully with some major freshwater issues that are confronting humanity, scientists said at a 28 April news briefing about hydrological challenges that was held at the European Geosciences Union (EGU) General Assembly in Vienna, Austria. They presented an optimistic view that society can learn to cope more successfully with the natural hazards of floods and droughts but expressed pessimism about effectively dealing with the problem of water salinization from agriculture.

  11. Future Challenges and Opportunities in Aerodynamics

    NASA Technical Reports Server (NTRS)

    Kumar, Ajay; Hefner, Jerry N.

    2000-01-01

    Investments in aeronautics research and technology have declined substantially over the last decade, in part due to the perception that technologies required in aircraft design are fairly mature and readily available. This perception is being driven by the fact that aircraft configurations, particularly the transport aircraft, have evolved only incrementally, over last several decades. If however, one considers that the growth in air travel is expected to triple in the next 20 years, it becomes quickly obvious that the evolutionary development of technologies is not going to meet the increased demands for safety, environmental compatibility, capacity, and economic viability. Instead, breakthrough technologies will he required both in traditional disciplines of aerodynamics, propulsion, structures, materials, controls, and avionics as well as in the multidisciplinary integration of these technologies into the design of future aerospace vehicles concepts. The paper discusses challenges and opportunities in the field of aerodynamics over the next decade. Future technology advancements in aerodynamics will hinge on our ability, to understand, model, and control complex, three-dimensional, unsteady viscous flow across the speed range. This understanding is critical for developing innovative flow and noise control technologies and advanced design tools that will revolutionize future aerospace vehicle systems and concepts. Specifically, the paper focuses on advanced vehicle concepts, flow and noise control technologies, and advanced design and analysis tools.

  12. Expanding the role for psychology in addressing environmental challenges.

    PubMed

    Clayton, Susan; Devine-Wright, Patrick; Swim, Janet; Bonnes, Mirilia; Steg, Linda; Whitmarsh, Lorraine; Carrico, Amanda

    2016-04-01

    Environmental challenges, though daunting, present an important area for psychologists to apply their knowledge. Psychological theories, research methods, and interventions are essential for examining the questions about human impacts, tendencies, and capacities that are integral to constructing effective responses to these challenges. Although a great deal of relevant research has been done, there is scope for psychologists to be more extensively involved. Following a brief review of existing research, we outline some important new directions. We also highlight 2 key divergences, arguing that psychological research needs to expand beyond a traditional, theory-based and decontextualized approach to environmental issues to incorporate a contextualized or "place-based" approach and a willingness to collaborate in interdisciplinary research teams that focus on specific environmental problems. Suggestions for promoting such interdisciplinary collaborations are reviewed. We encourage psychologists to expand their engagement with important environmental issues through multiple research approaches in order to further their understanding of human behavior, contributions to human well-being, and relevance to other disciplines and to society. PMID:26147395

  13. Strategies to Address Common Challenges When Teaching in an Active Learning Classroom

    ERIC Educational Resources Information Center

    Petersen, Christina I.; Gorman, Kristen S.

    2014-01-01

    This chapter provides practical strategies for addressing common challenges that arise for teachers in active learning classrooms. Our strategies come from instructors with experience teaching in these environments.

  14. Strategic Science to Address Current and Future Space Weather Needs

    NASA Astrophysics Data System (ADS)

    Mannucci, A. J.; Schwadron, N.; Antiochos, S. K.; Bhattacharjee, A.; Bisi, M. M.; Gopalswamy, N.; Kamalabadi, F.; Pulkkinen, A. A.; Tobiska, W. K.; Weimer, D. R.; Withers, P.

    2014-12-01

    NASA's Living With a Star (LWS) program has contributed a wealth of scientific knowledge that is relevant to space weather and user needs. A targeted approach to science questions has resulted in leveraging new scientific knowledge to improve not only our understanding of the Heliophysics domain, but also to develop predictive capabilities in key areas of LWS science. This fascinating interplay between science and applications promises to benefit both domains. Scientists providing feedback to the LWS program are now discussing an evolution of the targeted approach that explicitly considers how new science improves, or enables, predictive capability directly. Long-term program goals are termed "Strategic Science Areas" (SSAs) that address predictive capabilities in six specific areas: geomagnetically induced currents, satellite drag, solar energetic particles, ionospheric total electron content, radio frequency scintillation induced by the ionosphere, and the radiation environment. SSAs are organized around user needs and the impacts of space weather on society. Scientists involved in the LWS program identify targeted areas of research that reference (or bear upon) societal needs. Such targeted science leads to new discoveries and is one of the valid forms of exploration. In this talk we describe the benefits of targeted science, and how addressing societal impacts in an appropriate way maintains the strong science focus of LWS, while also leading to its broader impacts.

  15. North American Water Program (NAWP): A Vision to Address North America's Freshwater Sustainability Challenges

    NASA Astrophysics Data System (ADS)

    Belvedere, D. R.; Houser, P.; van Oevelen, P. J.; Schiffer, R. A.; Entin, J. K.; Bosilovich, M. G.; Schlosser, C. A.; Wood, E. F.; Ek, M. B.

    2012-12-01

    Dramatically changing climates has had an indelible impact on North America's water crisis; the rapid melting of glaciers has profound implications for the sustainability of Canada's rivers. However, projected increases in water demand from increasing population, industrial, energy, and agriculture needs may have four times more impact on the water supply-demand imbalance than climate change. Reliable prediction of hydrologic change and extremes is of critical importance for policy and decision makers to adapt to these future water challenges. However, the models that we use to understand and forecast water availability, flooding, and drought are simply not up to the task of addressing our most pressing societal issues and national security. We need a decisive and coordinated effort to systematically improve water cycle prediction skill, coupled with reliable methodologies to translate those predictions into actionable water supply and quality information to support sustainable water management - this a primary motivation for the proposed North American Water Program (NAWP). To decisively address these challenges, we recommend that NAWP coalesce an interdisciplinary, international and interagency effort to make significant contributions to continental-to decision-scale hydroclimate science and solutions. By entraining, integrating and coordinating the vast array of interdisciplinary observational and prediction resources available, NAWP will significantly advance skill in predicting, assessing and managing variability and changes in North American water resources, as an integral part of the global climate system. We adopt three challenges to organize NAWP efforts. The first deals with developing a scientific basis and tools for mitigating and adapting to changes in the water supply-demand balance. The second challenge is benchmarking; to use incomplete and uncertain observations to assess water storage and quality dynamics, and to characterize the information

  16. North American Water Program (NAWP): A Vision to Address North America's Freshwater Sustainability Challenges

    NASA Astrophysics Data System (ADS)

    Houser, P. R.

    2013-05-01

    Dramatically changing climates has had an indelible impact on North America's water crisis; the rapid melting of glaciers has profound implications for the sustainability of Canada's rivers. However, projected increases in water demand from increasing population, industrial, energy, and agriculture needs may have four times more impact on the water supply-demand imbalance than climate change. Reliable prediction of hydrologic change and extremes is of critical importance for policy and decision makers to adapt to these future water challenges. However, the models that we use to understand and forecast water availability, flooding, and drought are simply not up to the task of addressing our most pressing societal issues and national security. We need a decisive and coordinated effort to systematically improve water cycle prediction skill, coupled with reliable methodologies to translate those predictions into actionable water supply and quality information to support sustainable water management - this a primary motivation for the proposed North American Water Program (NAWP). To decisively address these challenges, we recommend that NAWP coalesce an interdisciplinary, international and interagency effort to make significant contributions to continental-to decision-scale hydroclimate science and solutions. By entraining, integrating and coordinating the vast array of interdisciplinary observational and prediction resources available, NAWP will significantly advance skill in predicting, assessing and managing variability and changes in North American water resources, as an integral part of the global climate system. We adopt three challenges to organize NAWP efforts. The first deals with developing a scientific basis and tools for mitigating and adapting to changes in the water supply-demand balance. The second challenge is benchmarking; to use incomplete and uncertain observations to assess water storage and quality dynamics, and to characterize the information

  17. North American Water Program (NAWP): A Vision to Address North America's Freshwater Sustainability Challenges

    NASA Astrophysics Data System (ADS)

    Belvedere, D. R.; Houser, P. R.; Schiffer, R. A.; Entin, J. K.

    2013-12-01

    Dramatically changing climates has had an indelible impact on North America's water crisis; the rapid melting of glaciers has profound implications for the sustainability of Canada's rivers. However, projective increases in water demand from increasing population, industrial energy, and agriculture needs may have four times more impact on the water supply-demand imbalance than climate change. Reliable prediction of hydrologic change and extremes is of critical importance for policy and decision makers to adapt to these future water challenges. However, the models that we use to understand and forecast water availability, flooding, and drought are simply not up to the task of addressing our most pressing societal issues and national security. We need a decisive and coordinative effort to systematically improve water cycle prediction skill, coupled with reliable methodologies to translate those predictions into actionable water supply and quality information to support sustainable water management - this is a primary motivation for the proposed North American Water Program (NAWP). To decisively address these challenges, we recommend that NAWP coalesce an interdisciplinary, international and interagency effort to make significant contributions to continental-to-decision-scale hydroclimate science and solutions. By entraining, integrating and coordinating the vast array of interdisciplinary observationable and prediction resources available, NAWP will significantly advance skill in predicting, assessing, and managing variability and changes in North American water resources, as an integral part of the global climate system. We adopt three challenges to organize NAWP efforts. The first deals with developing a scientific basis and tools for mitigating and adapting to changes in the water supply-demand balance. The second challenge is benchmarking; to use incomplete and uncertain observations to assess water storage and quality dynamics, and to characterize the

  18. The future of IAEA safeguards: challenges and responses

    SciTech Connect

    Pilat, Joseph F; Budlong - Sylvester, Kory W

    2011-01-01

    For nearly two decades, the International Atomic Energy Agency (lAEA) has been transforming its safeguards system to address the challenges posed by undeclared nuclear programs, the associated revelation of an extensive non-State nuclear procurement network and other issues, including past limits to its verification mandate and the burden of noncompliance issues. Implementing the new measures, including those in the Additional Protocol, and integrating new and old safeguards measures, remains a work in progress. Implementation is complicated by factors including the limited teclmological tools that are available to address such issues as safeguarding bulk handling facilities, detection of undeclared facilities/activities, especially related to enrichment, etc. As this process continues, new challenges are arising, including the demands of expanding nuclear power production worldwide, so-called safeguards by design for a new generation of facilities, the possible IAEA role in a fissile material cutoff treaty and other elements of the arms control and disarmament agenda, the possible role in 'rollback' cases, etc. There is no doubt safeguards will need to evolve in the future, as they have over the last decades. In order for the evolutionary path to proceed, there will inter alia be a need to identify technological gaps, especially with respect to undeclared facilities, and ensure they are filled by adapting old safeguards technologies, by developing and introducing new and novel safeguards teclmologies and/or by developing new procedures and protocols. Safeguards will also need to respond to anticipated emerging threats and to future, unanticipated threats. This will require strategic planning and cooperation among Member States and with the Agency. This paper will address challenges to IAEA safeguards and the technological possibilities and R&D strategies needed to meet those challenges in the context of the forty-year evolution of safeguards, including the ongoing

  19. Psychosocial issues in space: future challenges.

    PubMed

    Sandal, G M

    2001-06-01

    As the duration of space flights increases and crews become more heterogeneous, psychosocial factors are likely to play an increasingly important role in determining mission success. The operations of the International Space Station and planning of interplanetary missions represent important future challenges for how to select, train and monitor crews. So far, empirical evidence about psychological factors in space is based on simulations and personnel in analog environments (i.e. polar expeditions, submarines). It is apparent that attempts to transfer from these environments to space requires a thorough analysis of the human behavior specific to the fields. Recommendations for research include the effects of multi-nationality on crew interaction, development of tension within crews and between Mission Control, and prediction of critical phases in adaptation over time. Selection of interpersonally compatible crews, pre-mission team training and implementation of tools for self-monitoring of psychological parameters ensure that changes in mission requirements maximize crew performance. PMID:11865868

  20. Addressing new analytical challenges in protein formulation development.

    PubMed

    Mach, Henryk; Arvinte, Tudor

    2011-06-01

    As the share of therapeutic proteins in the arsenal of modern medicine continue increasing, relatively little progress has been made in the development of analytical methods that would address specific needs encountered during the development of these new drugs. Consequently, the researchers resort to adaptation of existing instrumentation to meet the demands of rigorous bioprocess and formulation development. In this report, we present a number of such adaptations as well as new instruments that allow efficient and precise measurement of critical parameters throughout the development stage. The techniques include use of atomic force microscopy to visualize proteinacious sub-visible particles, use of extrinsic fluorescent dyes to visualize protein aggregates, particle tracking analysis, determination of the concentration of monoclonal antibodies by the analysis of second-derivative UV spectra, flow cytometry for the determination of subvisible particle counts, high-throughput fluorescence spectroscopy to study phase separation phenomena, an adaptation of a high-pressure liquid chromatography (HPLC) system for the measurement of solution viscosity and a variable-speed streamlined analytical ultracentrifugation method. An ex vivo model for understanding the factors that affect bioavailability after subcutaneous injections is also described. Most of these approaches allow not only a more precise insight into the nature of the formulated proteins, but also offer increased throughput while minimizing sample requirements. PMID:21392580

  1. Strengthening health information systems to address health equity challenges.

    PubMed Central

    Nolen, Lexi Bambas; Braveman, Paula; Dachs, J. Norberto W.; Delgado, Iris; Gakidou, Emmanuela; Moser, Kath; Rolfe, Liz; Vega, Jeanette; Zarowsky, Christina

    2005-01-01

    Special studies and isolated initiatives over the past several decades in low-, middle- and high-income countries have consistently shown inequalities in health among socioeconomic groups and by gender, race or ethnicity, geographical area and other measures associated with social advantage. Significant health inequalities linked to social (dis)advantage rather than to inherent biological differences are generally considered unfair or inequitable. Such health inequities are the main object of health development efforts, including global targets such as the Millennium Development Goals, which require monitoring to evaluate progress. However, most national health information systems (HIS) lack key information needed to assess and address health inequities, namely, reliable, longitudinal and representative data linking measures of health with measures of social status or advantage at the individual or small-area level. Without empirical documentation and monitoring of such inequities, as well as country-level capacity to use this information for effective planning and monitoring of progress in response to interventions, movement towards equity is unlikely to occur. This paper reviews core information requirements and potential databases and proposes short-term and longer term strategies for strengthening the capabilities of HIS for the analysis of health equity and discusses HIS-related entry points for supporting a culture of equity-oriented decision-making and policy development. PMID:16184279

  2. Aneesur Rahman Prize for Computational Physics Lecture: Addressing Dirac's Challenge

    NASA Astrophysics Data System (ADS)

    Chelikowsky, James

    2013-03-01

    After the invention of quantum mechanics, P. A. M. Dirac made the following observation: ``The underlying physical laws necessary for the mathematical theory of a large part of physics and the whole of chemistry are thus completely known, and the difficulty is only that the exact application of these laws leads to equations much too complicated to be soluble. It therefore becomes desirable that approximate practical methods of applying quantum mechanics should be developed, which can lead to an explanation of the main features of complex atomic systems...'' The creation of ``approximate practical methods'' in response to Dirac's challenge has included the one electron picture, density functional theory and the pseudopotential concept. The combination of such methods in conjunction with contemporary computational platforms and new algorithms offer the possibility of predicting properties of materials solely from knowledge of the atomic species present. I will give an overview of progress in this field with an emphasis on materials at the nanoscale. Support from the Department of Energy and the National Science Foundation is acknowledged.

  3. Palaeoceanography: motivations and challenges for the future.

    PubMed

    Robinson, Laura F; Siddall, Mark

    2012-12-13

    The ocean interacts with the atmosphere, biosphere and cryosphere in a complex way, modulating climate through the storage and transport of heat, nutrients and carbon. As such, it is important that we understand the ways in which the ocean behaves and the factors that can lead to change. In order to gain this understanding, we need to look back into the past, on time scales from recent decadal-scale change, through the abrupt changes of the Pleistocene and back to times when the Earth's climate was significantly different than the Holocene. A key challenge facing the field of palaeoceanography is to combine data and modelling in a common framework. Coupling palaeo-data and models should improve our knowledge of how the Earth works, and perhaps of more direct societal relevance, might enable us to provide better predictive capabilities in climate modelling. In this discussion paper, we examine the motivations, past successes and challenges facing palaeoceanographic studies. We then suggest a number of areas and approaches that we believe will allow palaeoceanography to continue to provide new insights into processes that affect future climate change. PMID:23129712

  4. Professionalism: challenges for dentistry in the future.

    PubMed

    Ozar, D T

    2012-11-01

    While countries varies significantly in the financing of dental care, they are much more alike in the delivery of dentistry. Dental care is principally provided in dental offices and clinics that are independent business entities whose business leaders are most often the dentists themselves. However society expects from dentists a level of professionalism (i.e. habitually acting ethically, both in terms of competence and conduct) in contrast to the methods and motivations of the marketplace. This is why the single most important challenge of dental professional ethics continues to be giving proper priority to patients' well being and building ethically correct decision-making relationships with patients while, at the same time, trying to maintain a successful business operation. If we look into dentistry's future, the centrality of this aspect of professional ethics is not likely to change, although the ways in which dentists might violate this trust will probably multiple as funding mechanisms become increasingly complex. It is important that dentists reflect with fresh eyes on their ethical commitments. One challenge is the increased availability of oral health information to the public and the fact that so many people are uncritical of the accuracy of information in the media and on the web. A second is the increase in the amount of health care advertising in many societies. A third is the growth of aesthetic dentistry that differs from standard oral health care in important and ethically significant ways. The fourth is insurance that frequently complicates the explanation of a patient's treatment alternatives and often brings a third party into the treatment decision relationship. The ethical challenges of each of these factors will be considered and ultimately tying it to the central theme of dental professionalism. PMID:23221268

  5. Ocean OSSEs: recent developments and future challenges

    NASA Astrophysics Data System (ADS)

    Kourafalou, V. H.

    2012-12-01

    Atmospheric OSSEs have had a much longer history of applications than OSSEs (and OSEs) in oceanography. Long standing challenges include the presence of coastlines and steep bathymetric changes, which require the superposition of a wide variety of space and time scales, leading to difficulties on ocean observation and prediction. For instance, remote sensing is critical for providing a quasi-synoptic oceanographic view, but the coverage is limited at the ocean surface. Conversely, in situ measurements are capable to monitor the entire water column, but at a single location and usually for a specific, short time. Despite these challenges, substantial progress has been made in recent years and international initiatives have provided successful OSSE/OSE examples and formed appropriate forums that helped define the future roadmap. These will be discussed, together with various challenges that require a community effort. Examples include: integrated (remote and in situ) observing system requirements for monitoring large scale and climatic changes, vs. short term variability that is particularly important on the regional and coastal spatial scales; satisfying the needs of both global and regional/coastal nature runs, from development to rigorous evaluation and under a clear definition of metrics; data assimilation in the presence of tides; estimation of real-time river discharges for Earth system modeling. An overview of oceanographic efforts that complement the standard OSSE methodology will also be given. These include ocean array design methods, such as representer-based analysis and adaptive sampling. Exciting new opportunities for both global and regional ocean OSSE/OSE studies have recently become possible with targeted periods of comprehensive data sets, such as the existing Gulf of Mexico observations from multiple sources in the aftermath of the DeepWater Horizon incident and the upcoming airborne AirSWOT, in preparation for the SWOT (Surface Water and Ocean

  6. Integrated wireless systems: The future has arrived (Keynote Address)

    NASA Astrophysics Data System (ADS)

    Rivoir, Roberto

    2005-06-01

    It is believed that we are just at the beginning with wireless, and that a new age is dawning for this breakthrough technology. Thanks to several years of industrial manufacturing in mass-market applications such as cellular phones, wireless technology has nowadays reached a level of maturity that, combined with other achievements arising from different fields, such as information technology, artificial intelligence, pervasive computing, science of new materials, and micro-electro-mechanical systems (MEMS), will enable the realization of a networked stream-flow of real-time information, that will accompany us in our daily life, in a total seamless, transparent fashion. As almost any application scenario will require the deployment of complex, miniaturized, almost "invisible" systems, operating with different wireless standards, hard technological challenges will have to be faced for designing and fabricating ultra-low-cost, reconfigurable, and multi-mode heterogeneous smart micro-devices. But ongoing, unending progresses on wireless technology keeps the promise of helping to solve important societal problems in the health-care, safety, security, industry, environment sectors, and in general opening the possibility for an improved quality of life at work, on travel, at home, practically "everywhere, anytime".

  7. Flexible Biomanufacturing Processes that Address the Needs of the Future.

    PubMed

    Diel, Bernhard; Manzke, Christian; Peuker, Thorsten

    2014-01-01

    : As the age of the blockbuster drug recedes, the business model for the biopharmaceutical industry is evolving at an ever-increasing pace. The personalization of medicine, the emergence of biosimilars and biobetters, and the need to provide vaccines globally are just some of the factors forcing biomanufacturers to rethink how future manufacturing capability is implemented. One thing is clear: the traditional manufacturing strategy of constructing large-scale, purpose-built, capital-intensive facilities will no longer meet the industry's emerging production and economic requirements. Therefore, the authors of this chapter describe the new approach for designing and implementing flexible production processes for monoclonal antibodies and focus on the points to consider as well as the lessons learned from past experience in engineering such systems. A conceptual integrated design is presented that can be used as a blueprint for next-generation biomanufacturing facilities. In addition, this chapter discusses the benefits of the new approach with respect to flexibility, cost, and schedule. The concept presented here can be applied to other biopharmaceutical manufacturing processes and facilities, including-but not limited to-vaccine manufacturing, multiproduct and/or multiprocess capability, clinical manufacturing, and so on. PMID:23949696

  8. The Future of Systems Aeronomy in Addressing New Science Frontiers

    NASA Astrophysics Data System (ADS)

    Kozyra, J. U.; Paxton, L. J.; Ridley, A.

    2005-12-01

    The future will see a new era in our ability to characterize the state of the sun-Earth system using the SEC Great Observatory, new electronic data handling and data mining technologies, high-performance sun-to-Earth models, new techniques for assimilation of sparse data, and the development of innovative worldwide research tools through integration of ground-based observing sites. The time has come to pull these developing capabilities together into an investigation that seeks to understand aeronomy at a higher level than has previously been possible. Systems Aeronomy is a study of this global system behavior but, more than that, it investigates the large-scale systems-level features that result from elemental processes, like ion-neutral coupling, plasma drifts or radiative cooling. Currently the TIMED mission is making important contributions in identifying and characterizing the "building block" processes that change, evolve and combine to form the system response. Systems Aeronomy must have observational, theoretical and computational components to succeed. One of the key requirements is the ability to capture global data sets and integrate them into a coherent picture of the ITM system and its relationship to geospace. Success requires enhanced coordination between operating satellites throughout the sun-Earth system, new techniques for creating global maps from networks of ground-based and satellite-based sensors, and a new level of international cooperation leveraging off IPY2007, IHY2007, eGY2007, CAWSES, ICESTAR, and other planned worldwide programs. Twenty years down the road, Systems Aeronomy will provide the foundation for understanding planetary atmospheres, significantly extend the range of useful space weather prediction, and provide an important approach for investigating the impacts of anthropogenic and climatological changes in the ITM and on the geospace system as a whole.

  9. Cenozoic biodiversity: goals, challenges and future prospects

    NASA Astrophysics Data System (ADS)

    Lazarus, David

    2014-05-01

    Understanding biodiversity is a major goal of modern science. Biologists document living diversity; study the factors that maintain it, and the effects biodiversity has on ecosystem services. Paleontologists try to understand these same issues by examining biodiversity in the geologic past, and how this history correlates to changes in past environments. Both research agendas are driven by concerns about how biodiversity can be sustained into the future, despite human impacts on biodiversity, including climate change. Measuring biodiversity is a major challenge. Generally only a subset of the total diversity that exist(s/ed) at any one location can actually be recorded, due to rarity of many species, or (for fossils) species that were not preserved. Taxa occurrence data not collected for biodiversity studies is also frequently incompletely recorded. Incomplete, inconsistent taxonomy; and for fossils also incorrect geologic ages for observations are other major sources of error. Several different methods are used to correct for these problems, such as subsampling occurrence data or using expert-compiled taxonomic catalogs. No method is normally fully satisfactory, but, depending on data quality, can often yield useful approximations of actual (usually relative) diversity. Assuming that diversity has been accurately estimated, a second challenge comes in comparing diversity to possible causal factors. A common approach is a statistical comparison between diversity and environmental data series. Whether this is a meaningful exercise depends on the underlying statistical model, and whether this is similar to the processes that we are trying to understand. If for example, we suspect diversity to respond largely only when environmental thresholds are crossed, a linear regression test is not very informative. Our understanding of possible processes is however still primitive, and a poor guide to model selection and analysis. Scale is also important (temporal, geographic

  10. Vegetation Hydrodynamics - Recent Developments and Future Challenges

    NASA Astrophysics Data System (ADS)

    Nepf, H. M.

    2014-12-01

    For over a century vegetation has been removed from channels and coastal zones to facilitate navigation and development. In recent decades, however, we have recognized the ecologic and economic benefits of aquatic vegetation. It buffers against coastal eutrophication, damps waves and coastal storm surge, provides habitat, inhibits bank erosion, and provides significant carbon storage. The management of watersheds and coastal zones has turned from vegetation removal to restoration. In the past 20 years, the study of vegetation hydrodynamics has accelerated to meet the need to understand feedbacks between vegetation, flow and sediment transport. This presentation will describe key features of vegetation hydrodynamics, first at the meadow scale and then at the scale of individual patches, examining how vegetation density and meadow (or patch) morphology impact flow, with subsequent implications for sediment fate. Finally, the talk highlights differences in turbulence generation between bare and vegetated beds that may limit the transfer of open channel sediment transport models to vegetated channels, creating the future challenge of defining sediment transport models appropriate for vegetated regions.

  11. Geospatial Brokering - Challenges and Future Directions

    NASA Astrophysics Data System (ADS)

    White, C. E.

    2012-12-01

    An important feature of many brokers is to facilitate straightforward human access to scientific data while maintaining programmatic access to it for system solutions. Standards-based protocols are critical for this, and there are a number of protocols to choose from. In this discussion, we will present a web application solution that leverages certain protocols - e.g., OGC CSW, REST, and OpenSearch - to provide programmatic as well as human access to geospatial resources. We will also discuss managing resources to reduce duplication yet increase discoverability, federated search solutions, and architectures that combine human-friendly interfaces with powerful underlying data management. The changing requirements witnessed in brokering solutions over time, our recent experience participating in the EarthCube brokering hack-a-thon, and evolving interoperability standards provide insight to future technological and philosophical directions planned for geospatial broker solutions. There has been much change over the past decade, but with the unprecedented data collaboration of recent years, in many ways the challenges and opportunities are just beginning.

  12. Developmental psychopathology: recent advances and future challenges

    PubMed Central

    Pollak, Seth D

    2015-01-01

    The integrative field of developmental psychopathology is having a huge impact on our understanding of human health and behavior. In this paper, I use the example of children’s early stress exposure to illustrate how developmental psychopathologists now tend to deemphasize diagnostic categories and, instead, emphasize the social and biological contexts, events and circumstances that have created opportunities for maladaptive responses and health problems in youth. This example shows that developmental psychopathology is increasing understanding of how children develop the abilities that allow them to cope effectively with challenges and what leads to failures in development of these abilities. Integrating research about the neurobiology of learning may prove to be a powerful future direction to understand how the environment regulates behavior. Learning processes become increasingly intricate and fine-tuned as relevant neuroanatomical systems develop, and as the range, complexity and amount of environmental information increases for the developing child. A focus on these processes allows psychopathologists to formulate questions about which neural mechanisms children use to process information, how these mechanisms are themselves shaped by social context, why adverse social environments confer risk for children, and, perhaps, what sorts of neutrally informed interventions might remediate the deficits in self-regulation that underlie common psychopathologies. PMID:26407771

  13. FERMI longitudinal diagnostics: results and future challenges

    NASA Astrophysics Data System (ADS)

    Veronese, Marco; Ferrari, E.; Allaria, E.; Cinquegrana, P.; Froelich, L.; Giannessi, L.; Penco, G.; Predonzani, M.; Rossi, F.; Sigalotti, P.; Ferianis, M.

    2015-05-01

    The seeded FEL FERMI has completed the commissioning of both the FEL lines, and it is now providing the user community with a coherent and tunable UV radiation (from 100 nm to 4 nm) in a number of different configurations. These also include original FEL-pump - FEL-probe schemes with twin-seeded FEL pulses. Among the key systems for the operation of FERMI, there is the femtosecond optical timing system and dedicated longitudinal diagnostics, specifically developed for FERMI. In this paper, after a short review of the FERMI optical timing system and of its routinely achieved performances, we focus on the results obtained from the suite of longitudinal diagnostics (Bunch Arrival Monitor, Electro Optical sampling station and RF deflectors) all operating in single shot and with 10s fs resolution which demonstrate the FERMI achieved performances. The longitudinal diagnostics measurements are compared between these device and other device on shot-to-shot basis, looking for correlations between machine parameters. Finally future challenges in terms of improvement of existing diagnostics, planned installations and possible upgrades are discussed.

  14. Evolution of Altimetry Calibration and Future Challenges

    NASA Technical Reports Server (NTRS)

    Fu, Lee-Lueng; Haines, Bruce J.

    2012-01-01

    Over the past 20 years, altimetry calibration has evolved from an engineering-oriented exercise to a multidisciplinary endeavor driving the state of the art. This evolution has been spurred by the developing promise of altimetry to capture the large-scale, but small-amplitude, changes of the ocean surface containing the expression of climate change. The scope of altimeter calibration/validation programs has expanded commensurately. Early efforts focused on determining a constant range bias and verifying basic compliance of the data products with mission requirements. Contemporary investigations capture, with increasing accuracies, the spatial and temporal characteristics of errors in all elements of the measurement system. Dedicated calibration sites still provide the fundamental service of estimating absolute bias, but also enable long-term monitoring of the sea-surface height and constituent measurements. The use of a network of island and coastal tide gauges has provided the best perspective on the measurement stability, and revealed temporal variations of altimeter measurement system drift. The cross-calibration between successive missions provided fundamentally new information on the performance of altimetry systems. Spatially and temporally correlated errors pose challenges for future missions, underscoring the importance of cross-calibration of new measurements against the established record.

  15. Challenges to therapy in the future.

    PubMed

    O'Morain, C; Montague, S

    2000-01-01

    Quadruple therapy (with a proton pump inhibitor (PPI), metronidazole, tetracycline and bismuth) is generally reserved for second-line treatment; however, studies using this regimen for 7 days have found it to be effective even in metronidazole-resistant strains. Resistance is an ongoing problem with antimicrobial therapy but considerable progress has now been made into understanding the underlying genetic mechanisms of this process. Metronidazole resistance in Europe is usually in the range of 20-30% of strains but may be as high as 70% in some countries. One genetic mechanism involved is thought to be a mutation of the rdxA gene. Macrolide resistance appears to be on the increase in Europe, varying from 1% in some countries to 13% in others. The genetic mechanism involved has been shown to be a point mutation of a ribosomal RNA. Amoxicillin resistance is an emerging problem that has an adverse effect on eradication rates in clinical practice. Resistance has been shown to be caused by the absence of one of the four binding proteins in the cell wall. Few novel antibiotics have been developed for use in eradication therapy, although rifabutin, secnidazole and furazolidone have shown some success as part of combination therapy. Alternative therapies that have been tested include mucosal protective agents which have been used in place of a PPI in some eradication regimens with some success, and the somatostatin analog, octreotide, that has been used as part of quadruple therapy in place of a PPI and produced eradication rates of approximately 88%. The ultimate challenge is still to develop a safe and effective vaccine against Helicobacter pylori. Current and future research will also focus on identifying genetic targets for therapy, adhesion molecule analogs to prevent binding of the bacterium, and urease inhibitors. The current triple therapy treatment options available for the eradication of Helicobacter pylori infection are over 90% effective in susceptible

  16. Spatial Epidemiology: Current Approaches and Future Challenges

    PubMed Central

    Elliott, Paul; Wartenberg, Daniel

    2004-01-01

    Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors. We focus on small-area analyses, encompassing disease mapping, geographic correlation studies, disease clusters, and clustering. Advances in geographic information systems, statistical methodology, and availability of high-resolution, geographically referenced health and environmental quality data have created unprecedented new opportunities to investigate environmental and other factors in explaining local geographic variations in disease. They also present new challenges. Problems include the large random component that may predominate disease rates across small areas. Though this can be dealt with appropriately using Bayesian statistics to provide smooth estimates of disease risks, sensitivity to detect areas at high risk is limited when expected numbers of cases are small. Potential biases and confounding, particularly due to socioeconomic factors, and a detailed understanding of data quality are important. Data errors can result in large apparent disease excess in a locality. Disease cluster reports often arise nonsystematically because of media, physician, or public concern. One ready means of investigating such concerns is the replication of analyses in different areas based on routine data, as is done in the United Kingdom through the Small Area Health Statistics Unit (and increasingly in other European countries, e.g., through the European Health and Environment Information System collaboration). In the future, developments in exposure modeling and mapping, enhanced study designs, and new methods of surveillance of large health databases promise to improve our ability to understand the complex relationships of environment to health. PMID:15198920

  17. Challenging Futures Studies To Enhance Participatory River Basin Management

    NASA Astrophysics Data System (ADS)

    van der Helm, R.

    Can the field of futures research help advance participatory management of river basins? This question is supposed to be answered by the present study of which this paper will mainly address the theoretical and conceptual point of view. The 2000 EU Framework directive on water emphasises at least two aspects that will mark the future management of river basins: the need for long-term planning, and a demand for participation. Neither the former nor the latter are new concepts as such, but its combination is in some sense revolutionary. Can long-term plans be made (and implemented) in a participative way, what tools could be useful in this respect, and does this lead to a satisfactory situation in terms of both reaching physical targets and enhancing social-institutional manageability? A possibly rich way to enter the discussion is to challenge futures research as a concept and a practice for enabling multiple stakeholders to design appropriate policies. Futures research is the overall field in which several methods and techniques (like scenario analysis) are mobilised to systematically think through and/or design the future. As such they have proven to be rich exercises to trigger ideas, stimulate debate and design desirable futures (and how to get there). More importantly these exercises have the capability to reconstitute actor relations, and by nature go beyond the institutional boundaries. Arguably the relation between futures research and the planning process is rather distant. Understandably commitments on the direct implementation of the results are hardly ever made, but its impact on changes in the capabilities of the network of actors involved may be large. As a hypothesis we consider that the distant link between an image of the future and the implementation in policy creates sufficient distance for actors to participate (in terms of responsibilities, legal constraints, etc.) and generate potentials, and enough degrees of freedom needed for a successful

  18. Challenge of the Future: Visions and Versions.

    ERIC Educational Resources Information Center

    Conboy, William A., Ed.

    This book presents background information and approximately 40 articles on various aspects of the future. It is intended for use as a textbook and/or reader in advanced high school or college level future studies courses. The objectives are to help students of the future examine major problems and issues and to encourage them to devise new models…

  19. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry

    SciTech Connect

    2011-03-07

    AMO is developing advanced technologies that cut energy use and carbon emissions in some of the most energy-intensive processes within U.S. manufacturing. The brochure describes the AMO R&D projects that address these challenges.

  20. Addressing China's grand challenge of achieving food security while ensuring environmental sustainability.

    PubMed

    Lu, Yonglong; Jenkins, Alan; Ferrier, Robert C; Bailey, Mark; Gordon, Iain J; Song, Shuai; Huang, Jikun; Jia, Shaofeng; Zhang, Fusuo; Liu, Xuejun; Feng, Zhaozhong; Zhang, Zhibin

    2015-02-01

    China's increasingly urbanized and wealthy population is driving a growing and changing demand for food, which might not be met without significant increase in agricultural productivity and sustainable use of natural resources. Given the past relationship between lack of access to affordable food and political instability, food security has to be given a high priority on national political agendas in the context of globalization. The drive for increased food production has had a significant impact on the environment, and the deterioration in ecosystem quality due to historic and current levels of pollution will potentially compromise the food production system in China. We discuss the grand challenges of not only producing more food but also producing it sustainably and without environmental degradation. In addressing these challenges, food production should be considered as part of an environmental system (soil, air, water, and biodiversity) and not independent from it. It is imperative that new ways of meeting the demand for food are developed while safeguarding the natural resources upon which food production is based. We present a holistic approach to both science and policy to ensure future food security while embracing the ambition of achieving environmental sustainability in China. It is a unique opportunity for China to be a role model as a new global player, especially for other emerging economies. PMID:26601127

  1. Addressing China’s grand challenge of achieving food security while ensuring environmental sustainability

    PubMed Central

    Lu, Yonglong; Jenkins, Alan; Ferrier, Robert C.; Bailey, Mark; Gordon, Iain J.; Song, Shuai; Huang, Jikun; Jia, Shaofeng; Zhang, Fusuo; Liu, Xuejun; Feng, Zhaozhong; Zhang, Zhibin

    2015-01-01

    China’s increasingly urbanized and wealthy population is driving a growing and changing demand for food, which might not be met without significant increase in agricultural productivity and sustainable use of natural resources. Given the past relationship between lack of access to affordable food and political instability, food security has to be given a high priority on national political agendas in the context of globalization. The drive for increased food production has had a significant impact on the environment, and the deterioration in ecosystem quality due to historic and current levels of pollution will potentially compromise the food production system in China. We discuss the grand challenges of not only producing more food but also producing it sustainably and without environmental degradation. In addressing these challenges, food production should be considered as part of an environmental system (soil, air, water, and biodiversity) and not independent from it. It is imperative that new ways of meeting the demand for food are developed while safeguarding the natural resources upon which food production is based. We present a holistic approach to both science and policy to ensure future food security while embracing the ambition of achieving environmental sustainability in China. It is a unique opportunity for China to be a role model as a new global player, especially for other emerging economies. PMID:26601127

  2. Future challenges to microbial food safety.

    PubMed

    Havelaar, Arie H; Brul, Stanley; de Jong, Aarieke; de Jonge, Rob; Zwietering, Marcel H; Ter Kuile, Benno H

    2010-05-30

    Despite significant efforts by all parties involved, there is still a considerable burden of foodborne illness, in which micro-organisms play a prominent role. Microbes can enter the food chain at different steps, are highly versatile and can adapt to the environment allowing survival, growth and production of toxic compounds. This sets them apart from chemical agents and thus their study from food toxicology. We summarize the discussions of a conference organized by the Dutch Food and Consumer Products Safety Authority and the European Food Safety Authority. The goal of the conference was to discuss new challenges to food safety that are caused by micro-organisms as well as strategies and methodologies to counter these. Management of food safety is based on generally accepted principles of Hazard Analysis Critical Control Points and of Good Manufacturing Practices. However, a more pro-active, science-based approach is required, starting with the ability to predict where problems might arise by applying the risk analysis framework. Developments that may influence food safety in the future occur on different scales (from global to molecular) and in different time frames (from decades to less than a minute). This necessitates development of new risk assessment approaches, taking the impact of different drivers of change into account. We provide an overview of drivers that may affect food safety and their potential impact on foodborne pathogens and human disease risks. We conclude that many drivers may result in increased food safety risks, requiring active governmental policy setting and anticipation by food industries whereas other drivers may decrease food safety risks. Monitoring of contamination in the food chain, combined with surveillance of human illness and epidemiological investigations of outbreaks and sporadic cases continue to be important sources of information. New approaches in human illness surveillance include the use of molecular markers for

  3. The Challenges and Potential of Nuclear Energy for Addressing Climate Change

    SciTech Connect

    Kim, Son H.; Edmonds, James A.

    2007-10-24

    The response to climate change and the stabilization of atmospheric greenhouse gas concentrations has major implications for the global energy system. Stabilization of atmospheric carbon dioxide (CO2) concentrations requires a peak and an indefinite decline of global CO2 emissions. Nuclear energy, along with other technologies, has the potential to contribute to the growing demand for energy without emitting CO2. Nuclear energy is of particular interest because of its global prevalence and its current significant contribution, nearly 20%, to the world’s electricity supply. We have investigated the value of nuclear energy in addressing climate change, and have explored the potential challenges for the rapid and large-scale expansion of nuclear energy as a response to climate change. The scope of this study is long-term and the modeling time frame extends out a century because the nature of nuclear energy and climate change dictate that perspective. Our results indicate that the value of the nuclear technology option for addressing climate change is denominated in trillions of dollars. Several-fold increases to the value of the nuclear option can be expected if there is limited availability of competing carbon-free technologies, particularly fossil-fuel based technologies that can capture and sequester carbon. Challenges for the expanded global use of nuclear energy include the global capacity for nuclear construction, proliferation, uranium availability, and waste disposal. While the economic costs of nuclear fuel and power are important, non-economic issues transcend the issues of costs. In this regard, advanced nuclear technologies and new vision for the global use of nuclear energy are important considerations for the future of nuclear power and climate change.

  4. Small molecule MALDI MS imaging: Current technologies and future challenges.

    PubMed

    Trim, Paul J; Snel, Marten F

    2016-07-15

    Imaging of specific small molecules is particularly challenging using conventional optical microscopy techniques. This has led to the development of alternative imaging modalities, including mass spectrometry (MS)-based methods. This review aims to provide an overview of the technologies, methods and future directions of laser-based mass spectrometry imaging (MSI) of small molecules. In particular it will focus on matrix-assisted laser desorption/ionization (MALDI) as the ion source, although other laser mass spectrometry methods will also be discussed to provide context, both historical and current. Small molecule MALDI MSI has been performed on a wide variety of instrument platforms: these are reviewed, as are the laser systems that are commonly used in this technique. Instrumentation and methodology cross over in the areas of achieving optimal spatial resolution, a key parameter in obtaining meaningful data. Also discussed is sample preparation, which is pivotal in maintaining sample integrity, providing a true reflection of the distribution of analytes, spatial resolution and sensitivity. Like all developing analytical techniques there are challenges to be overcome. Two of these are dealing with sample complexity and obtaining quantitative information from an imaging experiment. Both of these topics are addressed. Finally, novel experiments including non-MALDI laser ionization techniques are highlighted and a future perspective on the role of MALDI MSI in the small molecule arena is provided. PMID:26804564

  5. Management of Dynamic Biomedical Terminologies: Current Status and Future Challenges

    PubMed Central

    Dos Reis, J. C.; Pruski, C.

    2015-01-01

    Summary Objectives Controlled terminologies and their dependent artefacts provide a consensual understanding of a domain while reducing ambiguities and enabling reasoning. However, the evolution of a domain’s knowledge directly impacts these terminologies and generates inconsistencies in the underlying biomedical information systems. In this article, we review existing work addressing the dynamic aspect of terminologies as well as their effects on mappings and semantic annotations. Methods We investigate approaches related to the identification, characterization and propagation of changes in terminologies, mappings and semantic annotations including techniques to update their content. Results and conclusion Based on the explored issues and existing methods, we outline open research challenges requiring investigation in the near future. PMID:26293859

  6. Solar-powered airplanes: A historical perspective and future challenges

    NASA Astrophysics Data System (ADS)

    Zhu, Xiongfeng; Guo, Zheng; Hou, Zhongxi

    2014-11-01

    Solar-powered airplanes are studied in this research. A solar-powered airplane consumes solar energy instead of traditional fossil fuels; thus it has received a significant amount of interest from researchers and the public alike. The historical development of solar-powered airplanes is reviewed. Notable prototypes, particularly those sponsored by the government, are introduced in detail. Possible future applications of solar-powered airplanes in the civilian and military fields are proposed. Finally, the challenges being faced by solar-powered airplanes are discussed. This study proposes that the solar-powered airplanes are potential alternatives to some present technologies and that they complement current satellites, traditional airplanes, airships, and balloons. However, these planes require further development and enormous technical obstacles must be addressed.

  7. Single-cell RNA-seq: advances and future challenges

    PubMed Central

    Saliba, Antoine-Emmanuel; Westermann, Alexander J.; Gorski, Stanislaw A.; Vogel, Jörg

    2014-01-01

    Phenotypically identical cells can dramatically vary with respect to behavior during their lifespan and this variation is reflected in their molecular composition such as the transcriptomic landscape. Single-cell transcriptomics using next-generation transcript sequencing (RNA-seq) is now emerging as a powerful tool to profile cell-to-cell variability on a genomic scale. Its application has already greatly impacted our conceptual understanding of diverse biological processes with broad implications for both basic and clinical research. Different single-cell RNA-seq protocols have been introduced and are reviewed here—each one with its own strengths and current limitations. We further provide an overview of the biological questions single-cell RNA-seq has been used to address, the major findings obtained from such studies, and current challenges and expected future developments in this booming field. PMID:25053837

  8. Health Inequalities Policy in Korea: Current Status and Future Challenges

    PubMed Central

    Lee, Sang-il

    2012-01-01

    In recent years, health inequalities have become an important public health concern and the subject of both research and policy attention in Korea. Government reports, as well as many epidemiological studies, have provided evidence that a wide range of health outcomes and health-related behaviors are socioeconomically patterned, and that the magnitude of health inequalities is even increasing. However, except for the revised Health Plan 2010 targets for health equity, few government policies have explicitly addressed health inequalities. Although a number of economic and social policies may have had an impact on health inequalities, such impact has scarcely been evaluated. In this review, we describe the current status of research and policy on health inequalities in Korea. We also suggest future challenges of approaches and policies to reduce health inequalities and highlight the active and intensive engagement of many policy sectors and good evidence for interventions that will make meaningful reduction of health inequalities possible. PMID:22661869

  9. Addressing the Challenges of Mainstreaming Education for Sustainable Development in Higher Education

    ERIC Educational Resources Information Center

    Down, Lorna

    2006-01-01

    Purpose: The purpose of this paper is to address research on major challenges faced in attempting to mainstream education for sustainable development (ESD). Design/methodology/approach: The research is based on a project for infusing ESD in a teachers' college programme in Jamaica. Findings: Challenges include colleagues' scepticism, students'…

  10. Making Pedagogical Decisions to Address Challenges of Joint Jewish-Bedouin Environmental Projects in Israel

    ERIC Educational Resources Information Center

    Alkaher, Iris; Tal, Tali

    2016-01-01

    This interpretive study identifies challenges of working with Bedouin and Jewish Israeli youth in two multicultural projects: education for sustainability and place-conscious education. It also describes the ways the adult project leaders addressed these challenges and their views on the effectiveness of their decisions. Participants comprised 16…

  11. Towards addressing transient learning challenges in undergraduate physics: an example from electrostatics

    NASA Astrophysics Data System (ADS)

    Fredlund, T.; Linder, C.; Airey, J.

    2015-09-01

    In this article we characterize transient learning challenges as learning challenges that arise out of teaching situations rather than conflicts with prior knowledge. We propose that these learning challenges can be identified by paying careful attention to the representations that students produce. Once a transient learning challenge has been identified, teachers can create interventions to address it. By illustration, we argue that an appropriate way to design such interventions is to create variation around the disciplinary-relevant aspects associated with the transient learning challenge.

  12. Addressing the Grand Challenge of atmospheric carbon dioxide: geologic sequestration vs. biological recycling

    PubMed Central

    2011-01-01

    On February 15, 2008, the National Academy of Engineering unveiled their list of 14 Grand Challenges for Engineering. Building off of tremendous advancements in the past century, these challenges were selected for their role in assuring a sustainable existence for the rapidly increasing global community. It is no accident that the first five Challenges on the list involve the development of sustainable energy sources and management of environmental resources. While the focus of this review is to address the single Grand Challenge of "develop carbon sequestration methods", is will soon be clear that several other Challenges are intrinsically tied to it through the principles of sustainability. How does the realm of biological engineering play a role in addressing these Grand Challenges? PMID:22047501

  13. Remote Sensing of Ecosystem Health: Opportunities, Challenges, and Future Perspectives

    PubMed Central

    Li, Zhaoqin; Xu, Dandan; Guo, Xulin

    2014-01-01

    Maintaining a healthy ecosystem is essential for maximizing sustainable ecological services of the best quality to human beings. Ecological and conservation research has provided a strong scientific background on identifying ecological health indicators and correspondingly making effective conservation plans. At the same time, ecologists have asserted a strong need for spatially explicit and temporally effective ecosystem health assessments based on remote sensing data. Currently, remote sensing of ecosystem health is only based on one ecosystem attribute: vigor, organization, or resilience. However, an effective ecosystem health assessment should be a comprehensive and dynamic measurement of the three attributes. This paper reviews opportunities of remote sensing, including optical, radar, and LiDAR, for directly estimating indicators of the three ecosystem attributes, discusses the main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system, and provides some future perspectives. The main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system are: (1) scale issue; (2) transportability issue; (3) data availability; and (4) uncertainties in health indicators estimated from remote sensing data. However, the Radarsat-2 constellation, upcoming new optical sensors on Worldview-3 and Sentinel-2 satellites, and improved technologies for the acquisition and processing of hyperspectral, multi-angle optical, radar, and LiDAR data and multi-sensoral data fusion may partly address the current challenges. PMID:25386759

  14. Remote sensing of ecosystem health: opportunities, challenges, and future perspectives.

    PubMed

    Li, Zhaoqin; Xu, Dandan; Guo, Xulin

    2014-01-01

    Maintaining a healthy ecosystem is essential for maximizing sustainable ecological services of the best quality to human beings. Ecological and conservation research has provided a strong scientific background on identifying ecological health indicators and correspondingly making effective conservation plans. At the same time, ecologists have asserted a strong need for spatially explicit and temporally effective ecosystem health assessments based on remote sensing data. Currently, remote sensing of ecosystem health is only based on one ecosystem attribute: vigor, organization, or resilience. However, an effective ecosystem health assessment should be a comprehensive and dynamic measurement of the three attributes. This paper reviews opportunities of remote sensing, including optical, radar, and LiDAR, for directly estimating indicators of the three ecosystem attributes, discusses the main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system, and provides some future perspectives. The main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system are: (1) scale issue; (2) transportability issue; (3) data availability; and (4) uncertainties in health indicators estimated from remote sensing data. However, the Radarsat-2 constellation, upcoming new optical sensors on Worldview-3 and Sentinel-2 satellites, and improved technologies for the acquisition and processing of hyperspectral, multi-angle optical, radar, and LiDAR data and multi-sensoral data fusion may partly address the current challenges. PMID:25386759

  15. Addressing challenges and needs in patient education targeting hardly reached patients with chronic diseases

    PubMed Central

    Varming, Annemarie Reinhardt; Torenholt, Rikke; Møller, Birgitte Lund; Vestergaard, Susanne; Engelund, Gitte

    2015-01-01

    Some patients do not benefit from participation in patient education due to reasons related to disease burden, literacy, and socioeconomic challenges. In this communication, we address more specifically both the challenges that these hardly reached patients face in relation to patient education programs and the challenges educators face when conducting patient education with hardly reached patients. We define principles for the format and content of dialogue tools to better support this patient group within the population of individuals with diabetes. PMID:25729695

  16. Challenges for future space power systems

    NASA Technical Reports Server (NTRS)

    Brandhorst, Henry W., Jr.

    1989-01-01

    Forecasts of space power needs are presented. The needs fall into three broad categories: survival, self-sufficiency, and industrialization. The cost of delivering payloads to orbital locations and from Low Earth Orbit (LEO) to Mars are determined. Future launch cost reductions are predicted. From these projections the performances necessary for future solar and nuclear space power options are identified. The availability of plentiful cost effective electric power and of low cost access to space are identified as crucial factors in the future extension of human presence in space.

  17. Large-Scale Data Challenges in Future Power Grids

    SciTech Connect

    Yin, Jian; Sharma, Poorva; Gorton, Ian; Akyol, Bora A.

    2013-03-25

    This paper describes technical challenges in supporting large-scale real-time data analysis for future power grid systems and discusses various design options to address these challenges. Even though the existing U.S. power grid has served the nation remarkably well over the last 120 years, big changes are in the horizon. The widespread deployment of renewable generation, smart grid controls, energy storage, plug-in hybrids, and new conducting materials will require fundamental changes in the operational concepts and principal components. The whole system becomes highly dynamic and needs constant adjustments based on real time data. Even though millions of sensors such as phase measurement units (PMUs) and smart meters are being widely deployed, a data layer that can support this amount of data in real time is needed. Unlike the data fabric in cloud services, the data layer for smart grids must address some unique challenges. This layer must be scalable to support millions of sensors and a large number of diverse applications and still provide real time guarantees. Moreover, the system needs to be highly reliable and highly secure because the power grid is a critical piece of infrastructure. No existing systems can satisfy all the requirements at the same time. We examine various design options. In particular, we explore the special characteristics of power grid data to meet both scalability and quality of service requirements. Our initial prototype can improve performance by orders of magnitude over existing general-purpose systems. The prototype was demonstrated with several use cases from PNNL’s FPGI and was shown to be able to integrate huge amount of data from a large number of sensors and a diverse set of applications.

  18. Challenges for future space power systems

    NASA Technical Reports Server (NTRS)

    Brandhorst, Henry W., Jr.

    1989-01-01

    The future appears rich in missions that will extend the frontiers of knowledge, human presence in space, and opportunities for profitable commerce. The key to success of these ventures is the availability of plentiful, cost effective electric power and assured, low cost access to space. While forecasts of space power needs are problematic, an assessment of future needs based on terrestrial experience was made. These needs fall into three broad categories-survival, self sufficiency and industrialization. The cost of delivering payloads to orbital locations from low earth orbit (LEO) to Mars was determined and future launch cost reductions projected. From these factors, then, projections of the performance necessary for future solar and nuclear space power options were made. These goals are largely dependent upon orbital location and energy storage needs.

  19. Biological approaches for addressing the grand challenge of providing access to clean drinking water

    PubMed Central

    2011-01-01

    The U.S. National Academy of Engineering (NAE) recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF). Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of providing access to clean drinking water. This issue must be addressed in part by removing or inactivating microbial and chemical contaminants in order to properly deliver water safe for human consumption. Despite many advances in technologies this challenge is expanding due to increased pressure on fresh water supplies and to new opportunities for growth of potentially pathogenic organisms. PMID:21453515

  20. A Future Star: Challenging Stereotypes of Diversity

    ERIC Educational Resources Information Center

    Hernandez, Paul; Loebickin, Karla

    2015-01-01

    Ice-breaking discussions around race and personal perspectives can be challenging in any classroom, they also are crucial to cultivating racial consciousness among those espousing that they know better. This provides the groundwork needed to implement--in a non-threatening manner--the creative, alternative methods that will combine students'…

  1. Forgings meet the challenges of the future

    SciTech Connect

    Mochnal, G.

    1996-04-01

    To meet and exceed the requirements of the customer of the future, the forging industry is entering a new era of increased productivity and technical advancements. The tools for this task have been developed as a result of a partnership among industry, government, and academia. As another consequence of this partnership, the Forging Industry Association and the Forging Industry Educational and Research Foundation are in the process of creating a Vision of the Future. This article will discuss advances in metal-forming simulation, billet heating systems, advanced die materials, and advanced forging presses.

  2. Research Challenges in Future Health Care Systems

    NASA Astrophysics Data System (ADS)

    Kulatunga, Harini

    Future health care systems will involve a network of heterogeneous resources providing different levels of service and will comprise of a physical and a virtual decision and control layer. The initial results presented here will lead to health care delivery with on-line decision making in order to meet QoS requirements and management targets.

  3. Spacecraft 2000: The challenge of the future

    NASA Technical Reports Server (NTRS)

    Brandhorst, Henry W., Jr.; Faymon, Karl A.; Bercaw, Robert W.

    1987-01-01

    Considerable opportunity exists to improve the systems, subsystems, components, etc., included in the space station bus, the non-payload portion of the spacecraft. The steps followed to date, the challenges being faced by industry, and the progress toward establishing a new NASA initiative which will identify the technologies required to build spacecraft of the 21st century and which will implement the technology development/validation programs necessary are described.

  4. Pancreatic Cancer: Current Progress and Future Challenges

    PubMed Central

    Hussain, S. Perwez

    2016-01-01

    Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, remains one of the highly lethal malignancies. The highly refractory nature of clinically advanced disease and lack of a reliable biomarker for early detection are major obstructions in improving patient outcome. The recent efforts, however, in understanding the pancreatic tumor biology have resulted in the recognition of novel addictions as well as vulnerabilities of tumor cells and are being assessed for their clinical potential. This special issue highlights some of the recent progress, complexity and challenges towards improving disease outcome in patients with this lethal malignancy. PMID:26929733

  5. Dark polar ionosphere: Progress and future challenges

    SciTech Connect

    Carlson, H.C. Jr.

    1994-01-01

    Since the end of the 1970s, we have seen enormous progress in our understanding of the polar ionosphere and its structuring. With this benchmark issue of Radio Science it is appropriate to reflect briefly on that passage and some key questions that lie ahead. The discussion here will concentrate on the winter hemisphere, in keeping with the conditions under which most of the data studied to date have been gathered. The polar ionosphere alternates between two states, depending on whether the interplanetary magnetic field (IMF) is southward or northward. The former state is characterized by approximately 100-1000 km islands of enhanced F region plasma, originating in sunlit upper midlatitudes, entering and traversing the polar cap. They become highly structured and produce severe scintillation. Despite much progress on the source, evolution, and ultimate fate of this polar plasma, we remain challenged by the process(es) which chop entering plasma into such islands. For northward IMF we have learned much about the near-Earth processes determining the character of polar cap arcs, velocity structure and electrodynamics, and energetics. A remaining challenge is to relate these structures to the topology and driving physical processes in the magnetosphere and solar wind. Here we sketch the principles behind the progress and the context of several key problem areas ahead.

  6. Passive Thermal Control Challenges for Future Exploration Missions

    NASA Technical Reports Server (NTRS)

    Rickman, Steven L.

    2004-01-01

    This slide presentation reviews the importance of developing passive thermal control for the future exploration missions envisioned in President Bush's call for human exploration of the Moon and Mars. Included in the presentation is a review of the conditions that make the thermal control very challenging on the Moon and Mars. With the future miniaturization of electronics components, power density and the associated challenges of electronics heat dissipation will provide new challenges. There is a challenge for improvement in modeling and analysis of thermal control systems, and for improved facilities to support testing of thermal-vacuum systems.

  7. Haze in China: current and future challenges.

    PubMed

    Li, Meina; Zhang, Lulu

    2014-06-01

    Regional haze which triggered both public anxiety and official concerns has been one of the most disastrous weather events in China in recent years. Haze not only had negative impact on daily life, but also an indicator of high concentrations of PM2.5 with the potential to adversely impact public health by damaging people's respiratory, cardiovascular, blood vessel of brain and nervous system. The dust-haze is an accumulated result for a long time of both natural factors and unhealthy economic growth model. In order to tackle air pollution, a number of policies and measures which target at reducing pollution emission and promoting alternative energy production had been implemented. Although significant improvement has occurred in China, change the development mode of "high growth, high pollution" and balance environmental conservation with the well-being of the population remains a challenge for China. PMID:24637256

  8. Future Challenges for Double Beta Decay Experiments

    NASA Astrophysics Data System (ADS)

    Elliott, Steven

    2015-10-01

    Neutrino oscillation experiments have shown that at least one neutrino has a mass greater than 50 meV. In the inverted hierarchy pattern of neutrino masses, one would expect an effective Majorana neutrino mass of 15 meV or greater. This fact has led to a strong resurgence of interest in neutrinoless double beta decay experiments that can reach this mass target. If this rare nuclear decay process exists it would demonstrate that Lepton number conservation is violated, that neutrinos are their own anti-particles and the decay rate would give an indication of the neutrino mass. This presentation will summarize the double beta decay experimental program with a focus on the technical challenges that will be faced.

  9. Facial Animations: Future Research Directions & Challenges

    NASA Astrophysics Data System (ADS)

    Alkawaz, Mohammed Hazim; Mohamad, Dzulkifli; Rehman, Amjad; Basori, Ahmad Hoirul

    2014-06-01

    Nowadays, computer facial animation is used in a significant multitude fields that brought human and social to study the computer games, films and interactive multimedia reality growth. Authoring the computer facial animation, complex and subtle expressions are challenging and fraught with problems. As a result, the current most authored using universal computer animation techniques often limit the production quality and quantity of facial animation. With the supplement of computer power, facial appreciative, software sophistication and new face-centric methods emerging are immature in nature. Therefore, this paper concentrates to define and managerially categorize current and emerged surveyed facial animation experts to define the recent state of the field, observed bottlenecks and developing techniques. This paper further presents a real-time simulation model of human worry and howling with detail discussion about their astonish, sorrow, annoyance and panic perception.

  10. Cognitive Biometrics: Challenges for the Future

    NASA Astrophysics Data System (ADS)

    Revett, Kenneth; de Magalhães, Sergio Tenreiro

    Cognitive biometrics is a novel approach to user authentication/identification which utilises a biosignal based approach. Specifically, current implementations rely on the use of the electroencephalogram (EEG), electrocardiogram (ECG), and the electrodermal response (EDR) as inputs into a traditional authentication scheme. The scientific basis for the deployment of biosignals resides principally on their uniqueness -for instance the theta power band in adults presents a phenotypic/genetic correlation of approximately 75%. The numbers are roughly the same for ECG, with an heritability correlation for the peak-to-peak (R-R interval) times of over 77%. For EDR, the results indicate that there is approximately a 50% heritability score (h2). The challenge with respect to cognitive biometrics based on biosignals is to enhance the information content of the acquired data.

  11. Wind Energy Status and Future Wind Engineering Challenges: Preprint

    SciTech Connect

    Thresher, R.; Schreck, S.; Robinson, M.; Veers, P.

    2008-08-01

    This paper describes the current status of wind energy technology, the potential for future wind energy development and the science and engineering challenges that must be overcome for the technology to meet its potential.

  12. Advances and Future Challenges in Printed Batteries.

    PubMed

    Sousa, Ricardo E; Costa, Carlos M; Lanceros-Méndez, Senentxu

    2015-11-01

    There is an increasing interest in thin and flexible energy storage devices to meet modern society's needs for applications such as radio frequency sensing, interactive packaging, and other consumer products. Printed batteries comply with these requirements and are an excellent alternative to conventional batteries for many applications. Flexible and microbatteries are also included in the area of printed batteries when fabricated using printing technologies. The main characteristics, advantages, disadvantages, developments, and printing techniques of printed batteries are presented and discussed in this Review. The state-of-the-art takes into account both the research and industrial levels. On the academic level, the research progress of printed batteries is divided into lithium-ion and Zn-manganese dioxide batteries and other battery types, with emphasis on the different materials for anode, cathode, and separator as well as in the battery design. With respect to the industrial state-of-the-art, materials, device formulations, and manufacturing techniques are presented. Finally, the prospects and challenges of printed batteries are discussed. PMID:26404647

  13. Addressing Challenging Behaviors in Head Start: A Closer Look at Program Policies and Procedures

    ERIC Educational Resources Information Center

    Quesenberry, Amanda C.; Hemmeter, Mary Louise; Ostrosky, Michaelene M.

    2011-01-01

    In this study, Head Start policies and procedures related to child guidance and addressing challenging behaviors were examined. Data were gathered from six Head Start programs in the Midwest, through interviews and document analysis. The findings provide a glimpse into how Head Start programs support children's social and emotional competence and…

  14. Addressing the Challenges and Needs of English-Speaking Caribbean Immigrant Students: Guidelines for School Counselors

    ERIC Educational Resources Information Center

    Morrison, Stephaney; Bryan, Julia

    2014-01-01

    Caribbean students are among the distinct immigrant groups in U.S. public schools with particular needs to be addressed by school counselors. This article discusses the challenges Caribbean immigrant students face that create obstacles to their academic and personal/social success. Guidelines for school counselors are outlined, which can be used…

  15. The Flipped Class: A Method to Address the Challenges of an Undergraduate Statistics Course

    ERIC Educational Resources Information Center

    Wilson, Stephanie Gray

    2013-01-01

    Undergraduate statistics courses are perceived as challenging by both students and instructors. Students' attitudes, motivation, math anxiety, and preparedness can negatively impact the student and instructor experience and have the potential to negatively impact student learning. This article describes an attempt to address some of these…

  16. Social Justice Leadership and Inclusion: Exploring Challenges in an Urban District Struggling to Address Inequities

    ERIC Educational Resources Information Center

    DeMatthews, David; Mawhinney, Hanne

    2014-01-01

    Research Approach: This cross case study describes the challenges that two principals working in one urban school district addressed while attempting to transform their school cultures to embrace an inclusion model. Analysis of interviews and observations in each school revealed the actions, values, and orientations of the individual leaders and…

  17. Addressing the Challenges Encountered during a Developmental Evaluation: Implications for Evaluation Practice

    ERIC Educational Resources Information Center

    Poth, Cheryl-Anne; Pinto, Dorothy; Howery, Kathy

    2011-01-01

    This article describes three challenges encountered during a developmental evaluation and explains how these were addressed from the evaluators' perspective. The evaluation was conducted to support the implementation of a three-year educational technology leadership project funded by the Alberta provincial government. The developmental evaluation…

  18. Pediatric cataract: challenges and future directions

    PubMed Central

    Medsinge, Anagha; Nischal, Ken K

    2015-01-01

    Cataract is a significant cause of visual disability in the pediatric population worldwide and can significantly impact the neurobiological development of a child. Early diagnosis and prompt surgical intervention is critical to prevent irreversible amblyopia. Thorough ocular evaluation, including the onset, duration, and morphology of a cataract, is essential to determine the timing for surgical intervention. Detailed assessment of the general health of the child, preferably in conjunction with a pediatrician, is helpful to rule out any associated systemic condition. Although pediatric cataracts have a diverse etiology, with the majority being idiopathic, genetic counseling and molecular testing should be undertaken with the help of a genetic counselor and/or geneticist in cases of hereditary cataracts. Advancement in surgical techniques and methods of optical rehabilitation has substantially improved the functional and anatomic outcomes of pediatric cataract surgeries in recent years. However, the phenomenon of refractive growth and the process of emmetropization have continued to puzzle pediatric ophthalmologists and highlight the need for future prospective studies. Posterior capsule opacification and secondary glaucoma are still the major postoperative complications necessitating long-term surveillance in children undergoing cataract surgery early in life. Successful management of pediatric cataracts depends on individualized care and experienced teamwork. We reviewed the etiology, preoperative evaluation including biometry, choice of intraocular lens, surgical techniques, and recent developments in the field of childhood cataract. PMID:25609909

  19. Pediatric cataract: challenges and future directions.

    PubMed

    Medsinge, Anagha; Nischal, Ken K

    2015-01-01

    Cataract is a significant cause of visual disability in the pediatric population worldwide and can significantly impact the neurobiological development of a child. Early diagnosis and prompt surgical intervention is critical to prevent irreversible amblyopia. Thorough ocular evaluation, including the onset, duration, and morphology of a cataract, is essential to determine the timing for surgical intervention. Detailed assessment of the general health of the child, preferably in conjunction with a pediatrician, is helpful to rule out any associated systemic condition. Although pediatric cataracts have a diverse etiology, with the majority being idiopathic, genetic counseling and molecular testing should be undertaken with the help of a genetic counselor and/or geneticist in cases of hereditary cataracts. Advancement in surgical techniques and methods of optical rehabilitation has substantially improved the functional and anatomic outcomes of pediatric cataract surgeries in recent years. However, the phenomenon of refractive growth and the process of emmetropization have continued to puzzle pediatric ophthalmologists and highlight the need for future prospective studies. Posterior capsule opacification and secondary glaucoma are still the major postoperative complications necessitating long-term surveillance in children undergoing cataract surgery early in life. Successful management of pediatric cataracts depends on individualized care and experienced teamwork. We reviewed the etiology, preoperative evaluation including biometry, choice of intraocular lens, surgical techniques, and recent developments in the field of childhood cataract. PMID:25609909

  20. Alcoholic hepatitis: current challenges and future directions.

    PubMed

    Singal, Ashwani K; Kamath, Patrick S; Gores, Gregory J; Shah, Vijay H

    2014-04-01

    Alcoholic hepatitis is a distinct clinical syndrome among people with chronic and active alcohol abuse, with a potential for 30%-40% mortality at 1 month among those with severe disease. Corticosteroids or pentoxifylline are the current pharmacologic treatment options, but they provide only about 50% survival benefit. These agents are recommended for patients with modified discriminant function (mDF) ≥ 32 or Model for End-Stage Liver Disease score ≥ 18. The Lille score is used to determine response to steroids. Currently, a minimum of 6 months of abstinence from alcohol use is required for patients to receive a liver transplant, a requirement that cannot be met by patients with severe alcoholic hepatitis nonresponsive to steroids (Lille score ≥ 0.45). Data are emerging on the benefit of liver transplantation in select patients with first episode of severe alcoholic hepatitis. This review also focuses on recent treatment trials in alcoholic hepatitis including liver transplantation and its associated controversies, as well as possible future targets and pharmacologic treatment options for patients with alcoholic hepatitis that are being pursued through upcoming consortium studies. PMID:23811249

  1. Satellite Ocean Color: Present Status, Future Challenges

    NASA Technical Reports Server (NTRS)

    Gregg, Watson W.; McClain, Charles R.; Zukor, Dorothy J. (Technical Monitor)

    2001-01-01

    We are midway into our 5th consecutive year of nearly continuous, high quality ocean color observations from space. The Ocean Color and Temperature Scanner/Polarization and Directionality of the Earth's Reflectances (OCTS/POLDER: Nov. 1996 - Jun. 1997), the Sea-viewing Wide Field-of-view Sensor (SeaWiFS: Sep. 1997 - present), and now the Moderate Resolution Imaging Spectrometer (MODIS: Sep. 2000 - present) have and are providing unprecedented views of chlorophyll dynamics on global scales. Global synoptic views of ocean chlorophyll were once a fantasy for ocean color scientists. It took nearly the entire 8-year lifetime of limited Coastal Zone Color Scanner (CZCS) observations to compile seasonal climatologies. Now SeaWIFS produces comparably complete fields in about 8 days. For the first time, scientists may observe spatial and temporal variability never before seen in a synoptic context. Even more exciting, we are beginning to plausibly ask questions of interannual variability. We stand at the beginning of long-time time series of ocean color, from which we may begin to ask questions of interdecadal variability and climate change. These are the scientific questions being addressed by users of the 18-year Advanced Very High Resolution Radiometer time series with respect to terrestrial processes and ocean temperatures. The nearly 5-year time series of ocean color observations now being constructed, with possibilities of continued observations, can put us at comparable standing with our terrestrial and physical oceanographic colleagues, and enable us to understand how ocean biological processes contribute to, and are affected by global climate change.

  2. The Historical Context, Current Development, and Future Challenges of Distance Education in Indonesia

    ERIC Educational Resources Information Center

    Zuhairi, Aminudin; Wahyono, Effendi; Suratinah, Sharon

    2006-01-01

    This article addresses the historical context, current development, and future challenges of distance education in Indonesia. Conditions related to the geography, demography, socio-economic and cultural situations, as well as the availability of technology have encouraged the use of distance education as a valid choice in providing access to…

  3. Planning for the Future of Geo-Cybereducation: Outcomes of the Workshop, Challenges, and Future Directions

    NASA Astrophysics Data System (ADS)

    Ryan, J. G.; Eriksson, S. C.

    2010-12-01

    Inspired by the recommendations of the NSF report “Fostering Learning in the Networked World: The Cyberlearning Opportunity and Challenge” (NSF08204), the NSF National STEM Digital Learning program funded “Planning for the Future of Geocybereducation” Workshop sought to bring together leaders from the geoscience education community, from major geoscience research initiatives, and from the growing public- and private-sector geoscience information community. The objectives of the workshop were to begin conversations aimed at identifying best practices and tools for geoscience cyber-education, in the context of both the changing nature of learners and of rapidly evolving geo-information platforms, and to provide guidance to the NSF as to necessary future directions and needs for funding. 65 participants met and interacted live for the two-day workshop, with ongoing post-meeting virtual interactions via a collaborative workspace (www.geocybered.ning.com). Topics addressed included the rapidly changing character of learners, the growing capabilities of geoscience information systems and their affiliated tools, and effective models for collaboration among educators, researchers and geoinformation specialists. Discussions at the meeting focused on the implications of changing learners on the educational process, the challenges for teachers and administrators in keeping pace, and on the challenges of communication among these divergent professional communities. Ongoing virtual discussions and collaborations have produced a draft workshop document, and the workshop conveners are maintaining the workshop site as a venue for ongoing discussion and interaction. Several key challenges were evident from the workshop discussions and subsequent interactions: a) the development of most of the large geoinformatics and geoscience research efforts were not pursued with education as a significant objective, resulting in limited financial support for such activities after the

  4. Tool for evaluating research implementation challenges: A sense-making protocol for addressing implementation challenges in complex research settings

    PubMed Central

    2013-01-01

    Background Many challenges arise in complex organizational interventions that threaten research integrity. This article describes a Tool for Evaluating Research Implementation Challenges (TECH), developed using a complexity science framework to assist research teams in assessing and managing these challenges. Methods During the implementation of a multi-site, randomized controlled trial (RCT) of organizational interventions to reduce resident falls in eight nursing homes, we inductively developed, and later codified the TECH. The TECH was developed through processes that emerged from interactions among research team members and nursing home staff participants, including a purposive use of complexity science principles. Results The TECH provided a structure to assess challenges systematically, consider their potential impact on intervention feasibility and fidelity, and determine actions to take. We codified the process into an algorithm that can be adopted or adapted for other research projects. We present selected examples of the use of the TECH that are relevant to many complex interventions. Conclusions Complexity theory provides a useful lens through which research procedures can be developed to address implementation challenges that emerge from complex organizations and research designs. Sense-making is a group process in which diverse members interpret challenges when available information is ambiguous; the groups’ interpretations provide cues for taking action. Sense-making facilitates the creation of safe environments for generating innovative solutions that balance research integrity and practical issues. The challenges encountered during implementation of complex interventions are often unpredictable; however, adoption of a systematic process will allow investigators to address them in a consistent yet flexible manner, protecting fidelity. Research integrity is also protected by allowing for appropriate adaptations to intervention protocols that

  5. Future Challenges of Modeling THMC Systems

    NASA Astrophysics Data System (ADS)

    Miller, S. A.; Heinze, T.; Hamidi, S.; Galvan, B.

    2014-12-01

    and future plans, and show that a GPU-based modeling approach is fast, high-resolution, and can reproduce experimental results of fluid injection experiments with numerical resolution at the grain-scale of the experiment.

  6. Medical rescue of naval combat: challenges and future.

    PubMed

    Jin, Hai; Hou, Li-Jun; Fu, Xiao-Bing

    2015-01-01

    There has been no large-scale naval combat in the last 30 years. With the rapid development of battleships, weapons manufacturing and electronic technology, naval combat will present some new characteristics. Additionally, naval combat is facing unprecedented challenges. In this paper, we discuss the topic of medical rescue at sea: what challenges we face and what we could do. The contents discussed in this paper contain battlefield self-aid buddy care, clinical skills, organized health services, medical training and future medical research programs. We also discuss the characteristics of modern naval combat, medical rescue challenges, medical treatment highlights and future developments of medical rescue at sea. PMID:26309738

  7. Advances in addressing technical challenges of point-of-care diagnostics in resource-limited settings

    PubMed Central

    Wang, ShuQi; Lifson, Mark A.; Inci, Fatih; Liang, Li-Guo; Sheng, Ye-Feng; Demirci, Utkan

    2016-01-01

    The striking prevalence of HIV, TB and malaria, as well as outbreaks of emerging infectious diseases, such as influenza A (H7N9), Ebola and MERS, poses great challenges for patient care in resource-limited settings (RLS). However, advanced diagnostic technologies cannot be implemented in RLS largely due to economic constraints. Simple and inexpensive point-of-care (POC) diagnostics, which rely less on environmental context and operator training, have thus been extensively studied to achieve early diagnosis and treatment monitoring in non-laboratory settings. Despite great input from material science, biomedical engineering and nanotechnology for developing POC diagnostics, significant technical challenges are yet to be overcome. Summarized here are the technical challenges associated with POC diagnostics from a RLS perspective and the latest advances in addressing these challenges are reviewed. PMID:26777725

  8. Advances in addressing technical challenges of point-of-care diagnostics in resource-limited settings.

    PubMed

    Wang, ShuQi; Lifson, Mark A; Inci, Fatih; Liang, Li-Guo; Sheng, Ye-Feng; Demirci, Utkan

    2016-04-01

    The striking prevalence of HIV, TB and malaria, as well as outbreaks of emerging infectious diseases, such as influenza A (H7N9), Ebola and MERS, poses great challenges for patient care in resource-limited settings (RLS). However, advanced diagnostic technologies cannot be implemented in RLS largely due to economic constraints. Simple and inexpensive point-of-care (POC) diagnostics, which rely less on environmental context and operator training, have thus been extensively studied to achieve early diagnosis and treatment monitoring in non-laboratory settings. Despite great input from material science, biomedical engineering and nanotechnology for developing POC diagnostics, significant technical challenges are yet to be overcome. Summarized here are the technical challenges associated with POC diagnostics from a RLS perspective and the latest advances in addressing these challenges are reviewed. PMID:26777725

  9. Resourcing Future Generations - Challenges for geoscience: a new IUGS initiative

    NASA Astrophysics Data System (ADS)

    Oberhänsli, Roland; Lambert, Ian

    2014-05-01

    In a world with rapidly increasing population and technological development new space based remote sensing tools allowed for new discoveries and production of water, energy- and mineral-resources, including minerals, soils and construction materials. This has impact on politics, socio-economic development and thus calls for a strong involvement of geosciences because one of humanities biggest challenges will be, to rise living standards particularly in less developed countries. Any growth will lead to an increase of demand for natural resources. But especially for readily available mineral resources supply appears to be limited. Particularly demand for so called high-tech commodities - platinum group or rare earth elements - increased. This happened often faster than new discoveries were made. All this, while areas available for exploration decreased as the need for urban and agricultural use increased. Despite strong efforts in increasing efficiency of recycling, shortage in some commodities has to be expected. A major concern is that resources are not distributed evenly on our planet. Thus supplies depend on political stability, socio-economic standards and pricing. In the light of these statements IUGS is scoping a new initiative, Resourcing Future Generations (RFG), which is predicated on the fact that mining will continue to be an essential activity to meet the needs of future generations. RFG is aimed at identifying and addressing key challenges involved in securing natural resources to meet global needs post-2030. We consider that mineral resources should be the initial focus, but energy, soils, water resources and land use should also be covered. Addressing the multi-generational needs for mineral and other natural resources requires data, research and actions under four general themes: 1. Comprehensive evaluation and quantification of 21st century supply and demand. 2. Enhanced understanding of subsurface as it relates to mineral (energy and groundwater

  10. Future Orientation in Times of Threat and Challenge: How Resilient Adolescents Construct Their Future

    ERIC Educational Resources Information Center

    Seginer, Rachel

    2008-01-01

    Drawing on the importance of future orientation for adolescent development this analysis presents a model describing how future orientation is affected by high challenge (or resilience) in the face of political violence. The analysis consists of three parts. The first two present future orientation conceptualization and the psychological processes…

  11. Addressing Issues of Broadening Participation Highlighted in the Report on the Future of Undergraduate Geoscience Education

    NASA Astrophysics Data System (ADS)

    McDaris, J. R.; Manduca, C. A.; Macdonald, H.; Iverson, E. A. R.

    2015-12-01

    The final report for the Summit on the Future of Geoscience Education lays out a consensus on issues that must be tackled by the geoscience community collectively if there are to be enough qualified people to fill the large number of expected geoscience job vacancies over the coming decade. Focus areas cited in the report include: Strengthening the connections between two-year colleges and four-year institutions Sharing and making use of successful recruitment and retention practices for students from underrepresented groups Making students aware of high-quality job prospects in the geosciences as well as its societal relevance The InTeGrate STEP Center for the Geosciences, the Supporting and Advancing Geoscience Education at Two-Year Colleges (SAGE 2YC) program, and the Building Strong Geoscience Departments (BSGD) project together have developed a suite of web resources to help faculty and program leaders begin to address these and other issues. These resources address practices that support the whole student, both in the classroom and as a part of the co-curriculum as well as information on geoscience careers, guidance for developing coherent degree programs, practical advice for mentoring and advising, and many others. In addition to developing web resources, InTeGrate has also undertaken an effort to profile successful program practices at a variety of institutions. An analysis of these data shows several common themes (e.g. proactive marketing, community building, research experiences) that align well with the existing literature on what works to support student success. But there are also indications of different approaches and emphases between Minority Serving Institutions (MSIs) and Primarily White Institutions (PWIs) as well as between different kinds of MSIs. Highlighting the different strategies in use can point both MSIs and PWIs to possible alternate solutions to the challenges their students face. InTeGrate - http

  12. Global challenges keynote address in memoriam to colleagues lost in the Malaysia airlines 17 crash

    PubMed Central

    Hankins, Catherine A.

    2016-01-01

    ABSTRACT Six colleagues working in the HIV field were killed when their flight en route to Kuala Lumpur was shot down over the Ukraine. This report is drawn from the in memoriam keynote opening address given at the 12th International AIDS Impact conference in Amsterdam in 2015. It highlights their tangible and valued roles in the HIV response and looks forward to the road ahead. It describes the ways in which we can build on their legacy to address current global challenges in HIV prevention and treatment and to mobilise the intensified, focused resources that are needed to turn the HIV epidemic on its head. PMID:26963879

  13. HIV and Hepatitis Testing: Global Progress, Challenges, and Future Directions.

    PubMed

    Easterbrook, Philippa; Johnson, Cheryl; Figueroa, Carmen; Baggaley, Rachel

    2016-01-01

    HIV infection and viral hepatitis due to HBV and HCV infection are major causes of chronic disease worldwide, and share some common routes of transmission, epidemiology, initial barriers faced in treatment access, and in strategies for a global public health response. Testing and diagnosis of HIV, HBV, and HCV infection is the gateway for access to both care and treatment and prevention services, and crucial for an effective HIV and hepatitis epidemic response. In this review article, we first summarize the common goals and guiding principles in a public health approach to HIV and hepatitis testing. We summarize the impressive global progress in HIV testing scale-up and evolution of approaches, with expansion of provider-initiated testing and counseling in clinical settings (particularly antenatal and tuberculosis clinics), the introduction of more community based testing services, and use of rapid diagnostic tests enabling provision of same-day test results. However, 46% of all people living with HIV are still unaware of their serostatus, and many continue to be diagnosed and start antiretroviral therapy late. As testing and treatment scale-up accelerates for an "treat all" approach, other challenges to address include how to better focus testing and reach those yet undiagnosed and most at risk, especially key populations, men, adolescents, and children. We summarize future directions in HIV testing to speed scale-up and close gaps that are addressed in the WHO 2015 consolidated HIV testing guidelines. In contrast to HIV, action in hepatitis testing and treatment has been fragmented and limited to a few countries, and there remains a large burden of undiagnosed cases globally. We summarize key challenges in the hepatitis testing response, including lack of simple, reliable, and low-cost diagnostic tests, laboratory capacity, and testing facilities; inadequate data to guide country specific hepatitis testing approaches and who to screen; stigmatization and social

  14. Positive thinking about the future in newspaper reports and presidential addresses predicts economic downturn.

    PubMed

    Sevincer, A Timur; Wagner, Greta; Kalvelage, Johanna; Oettingen, Gabriele

    2014-04-01

    Previous research has shown that positive thinking, in the form of fantasies about an idealized future, predicts low effort and poor performance. In the studies reported here, we used computerized content analysis of historical documents to investigate the relation between positive thinking about the future and economic development. During the financial crisis from 2007 to 2009, the more weekly newspaper articles in the economy page of USA Today contained positive thinking about the future, the more the Dow Jones Industrial Average declined in the subsequent week and 1 month later. In addition, between the New Deal era and the present time, the more presidential inaugural addresses contained positive thinking about the future, the more the gross domestic product and the employment rate declined in the presidents' subsequent tenures. These counterintuitive findings may help reveal the psychological processes that contribute to an economic crisis. PMID:24496968

  15. Challenges Addressing Unmet Need for Contraception: Voices of Family Planning Service Providers in Rural Tanzania.

    PubMed

    Baraka, Jitihada; Rusibamayila, Asinath; Kalolella, Admirabilis; Baynes, Colin

    2015-12-01

    Provider perspectives have been overlooked in efforts to address the challenges of unmet need for family planning (FP). This qualitative study was undertaken in Tanzania, using 22 key informant interviews and 4 focus group discussions. The research documents perceptions of healthcare managers and providers in a rural district on the barriers to meeting latent demand for contraception. Social-ecological theory is used to interpret the findings, illustrating how service capability is determined by the social, structural and organizational environment. Providers' efforts to address unmet need for FP services are constrained by unstable reproductive preferences, low educational attainment, and misconceptions about contraceptive side effects. Societal and organizational factors--such as gender dynamics, economic conditions, religious and cultural norms, and supply chain bottlenecks, respectively--also contribute to an adverse environment for meeting needs for care. Challenges that healthcare providers face interact and produce an effect which hinders efforts to address unmet need. Interventions to address this are not sufficient unless the supply of services is combined with systems strengthening and social engagement strategies in a way that reflects the multi-layered, social institutional problems. PMID:27337850

  16. Blood safety: Opportunities and challenges addressed through Critical Path research at FDA.

    PubMed

    Atreya, Chintamani D; Epstein, Jay S

    2007-01-01

    New scientific discoveries and technologies create opportunities for medical and public health advancement through development of innovative products. However, novel products and technologies bring new challenges to regulation. FDA recently established a 'Critical Path' research initiative to modernize regulatory science concepts and tools to meet the challenges of the 21st century. Central to this initiative is the concept that regulatory science is distinct from the 'discovery' science that generates ideas for development of new drugs, biologics, or medical devices. In this article, the authors discuss the concepts of FDA 'Critical Path' research and review examples of such research performed in the Office of Blood Research and Review within the Center for Biologics Research and Evaluation at FDA to illustrate how the 'Critical Path' research is being used to address opportunities and challenges impacting blood and blood products.: PMID:24980841

  17. Presidential address, 1997. General surgery in the year 2000: looking to the future

    PubMed Central

    Monaghan, Edmond D.

    1998-01-01

    The goal of the 1997 Canadian Association of General Surgeons presidential address was to predict the future for general surgery in Canada in an optimistic fashion. However, on the basis of its current status, the vision for general surgery also includes the reality of the problems that the specialty will face. General surgeons must become advocates so as to help resolve these problems for the community and for their patients. PMID:9627544

  18. Presidential address, 1995. Surgery 2000: a look back to the future

    PubMed Central

    Heughan, Christopher

    1996-01-01

    The present demoralized state of Canadian surgery is due to a number of short-term influences. They include financial restraints, the desire of government agencies to off-load blame for unpopular decisions onto doctors and altered public expectations. The major long-term challenge will be a shortage of physicians and a severe shortage of general surgeons because of the superimposition of longer-term trends in medical demographics on short-term political reactions to a perceived oversupply of doctors. General surgeons need to identify the significant, long-term threats and challenges. If they can do this and plan their responses knowledgably, with some measure of altruism, the future in general surgery will be a bright one for present and future residents and medical students. PMID:8640616

  19. NASA's Earth Science Enterprise: Future Science Missions, Objectives and Challenges

    NASA Technical Reports Server (NTRS)

    Habib, Shahid

    1998-01-01

    NASA has been actively involved in studying the planet Earth and its changing environment for well over thirty years. Within the last decade, NASA's Earth Science Enterprise has become a major observational and scientific element of the U.S. Global Change Research Program. NASA's Earth Science Enterprise management has developed a comprehensive observation-based research program addressing all the critical science questions that will take us into the next century. Furthermore, the entire program is being mapped to answer five Science Themes (1) land-cover and land-use change research (2) seasonal-to-interannual climate variability and prediction (3) natural hazards research and applications (4) long-term climate-natural variability and change research and (5) atmospheric ozone research. Now the emergence of newer technologies on the horizon and at the same time continuously declining budget environment has lead to an effort to refocus the Earth Science Enterprise activities. The intent is not to compromise the overall scientific goals, but rather strengthen them by enabling challenging detection, computational and space flight technologies those have not been practically feasible to date. NASA is planning faster, cost effective and relatively smaller missions to continue the science observations from space for the next decade. At the same time, there is a growing interest in the world in the remote sensing area which will allow NASA to take advantage of this by building strong coalitions with a number of international partners. The focus of this presentation is to provide a comprehensive look at the NASA's Earth Science Enterprise in terms of its brief history, scientific objectives, organization, activities and future direction.

  20. Latin America's present and future challenges in toxicology education

    SciTech Connect

    Rojas, M. . E-mail: martini@telcel.net.ve

    2005-09-01

    Industrialization that Latin America has experienced during the past 50 years, the increase of population and the growth of chemical-related industries has generated a variety of environmental problems that must be addressed. After assessing these profound changes, greater emphasis should be placed on the study of environmental health and toxicology. Latin American countries face many problems that are common to other developing nations. Therefore, there is a demand for safety assessment and regulatory control of chemicals that create a need for increasing numbers of toxicologists. To meet this demand, educational programs in toxicology have to be designed. This paper utilizes a consultation questionnaire that includes toxicology-network members, scientists and educational institutions where toxicology is taught. An analysis of the information collected is made, with an emphasis on what we currently lack and on future challenges for toxicology professionals. Although the response from the study institutions was 65% (13 countries out of 20), the paper aims to assess the present situation of toxicology. The convenience for a certification/recognition for toxicologists is also evaluated. Action needs to be taken to promote scientific development based on regional specific needs that require increasing at the number of toxicology programs, and promoting of cooperation between academics and researchers. Among the limitations we have are the variability of curricula, objectives and priorities. The increasing globalization of markets and regulations requires the harmonization of graduate/postgraduate programs to ensure that risk assessment and management are dealt with uniformly. Cooperation among our countries and international assistance should play a more prominent role in the promotion of regional integration and the more efficient utilization of international experience in defining educational policies.

  1. Soil and water conservation: Our history and future challenges

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Remembering our past is an essential first step into the future. Building upon that philosophy, our objective is to summarize two presentations from a 2012 Soil Science Society of America (SSSA) symposium focused on soil management challenges in response to climate change in order to examine: (1) ho...

  2. 17th Workshop on MHD Stability Control: addressing the disruption challenge for ITER

    NASA Astrophysics Data System (ADS)

    Buttery, Richard

    2013-08-01

    This annual workshop on magnetohydrodynamic stability control was held on 5-7 November 2012 at Columbia University in the city of New York, in the aftermath of a violent hydrodynamic instability event termed 'Hurricane Sandy'. Despite these challenging circumstances, Columbia University managed an excellent meeting, enabling the full participation of the community. This Workshop has been held since 1996 to help in the development of understanding and control of magnetohydrodynamic (MHD) instabilities for future fusion reactors. It covers a wide range of stability topics—from disruptions, to tearing modes, error fields, edge-localized modes (ELMs), resistive wall modes (RWMs) and ideal MHD—spanning many device types (tokamaks, stellarators and reversed field pinches) to identify commonalities in the physics and a means of control. The theme for 2012 was 'addressing the disruption challenge for ITER', and thus the first day had a heavy focus on both the avoidance and mitigation of disruptions in ITER. Key elements included understanding how to apply 3D fields to maintain stability, as well as managing the disruption process itself through mitigating loads in the thermal quench and handling so called 'runaway electrons'. This culminated in a panel discussion on the disruption mitigation strategy for ITER, which noted that heat load asymmetries during the thermal quench appear to be an artifact of MHD processes, and that runaway electron generation may be inevitable, suggesting research should focus on control and dissipation of the runaway beam. The workshop was combined this year with the annual US-Japan MHD Workshop, with a special section looking more deeply at 'Fundamentals of 3D Perturbed Equilibrium Control', with interesting sessions on 3D equilibrium reconstruction, RWM physics, novel control concepts such as non-magnetic sensing, adaptive control, q < 2 tokamak operation, and the effects of flow. The final day turned to tearing mode interactions

  3. COOP+ project: Promoting the cooperation among international Research Infrastructures to address global environmental challenges.

    NASA Astrophysics Data System (ADS)

    Bonet-García, Francisco; Materia, Paola; Kutsch, Werner; de Lucas, Jesús Marco; Tjulin, Anders

    2016-04-01

    During the Anthropocene, mankind will face several global environmental challenges. One of the first and more successful responses provided by Science to these challenges is the collecting of long-term series of biophysical variables in order to improve our knowledge of natural systems. The huge amount of information gathered during the last decades by Research Infrastructures (RIs) has helped to understand the structure and functioning of natural systems at local and regional scales. But how can we address the global cross-scale and cross-disciplinary challenges posed by the global environment change? We believe that it will be necessary to observe, model better and understand the whole biosphere using long term data generated by international RIs. RIs play a key role on many of the last advances and discoveries in science, from the observation of the Higgs Boson at CERN to the exploration of the Universe by the telescopes of the European Southern Observatory in Chile. The scale of complexity, instrumentation, computing resources, technological advances, and also of the investments, and the size of research collaborations, do not have precedents in Science. RIs in environmental field are developing fast, but the corresponding communities need yet to further reflect the need for a wider global collaboration because the challenges to tackle are in essence of global nature. This contribution describes how COOP+ project (EU Horizon 2020 Coordination and Support Action) will promote the cooperation among RIs at a global scale to address global environmental challenges. Our project evolves from the experience of the sucessful FP7 COOPEUS project (see http://www.coopeus.eu), which explored the use and access to data from RIs in environmental research in Europe and USA. The general goal of COOP+ is to strengthen the links and coordination of the ESFRI RIs related to Marine Science (EMSO), Arctic and Atmospheric Research (EISCAT), Carbon Observation (ICOS) and Biodiversity

  4. Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity

    PubMed Central

    Catenacci, Daniel V.T.

    2014-01-01

    The promise of ‘personalized cancer care’ with therapies toward specific molecular aberrations has potential to improve outcomes. However, there is recognized heterogeneity within any given tumor-type from patient to patient (inter-patient heterogeneity), and within an individual (intra-patient heterogeneity) as demonstrated by molecular evolution through space (primary tumor to metastasis) and time (after therapy). These issues have become hurdles to advancing cancer treatment outcomes with novel molecularly targeted agents. Classic trial design paradigms are challenged by heterogeneity, as they are unable to test targeted therapeutics against low frequency genomic ‘oncogenic driver’ aberrations with adequate power. Usual accrual difficulties to clinical trials are exacerbated by low frequencies of any given molecular driver. To address these challenges, there is need for innovative clinical trial designs and strategies implementing novel diagnostic biomarker technologies to account for inter-patient molecular diversity and scarce tissue for analysis. Importantly, there is also need for pre-defined treatment priority algorithms given numerous aberrations commonly observed within any one individual sample. Access to multiple available therapeutic agents simultaneously is crucial. Finally intra-patient heterogeneity through time may be addressed by serial biomarker assessment at the time of tumor progression. This report discusses various ‘next-generation’ biomarker-driven trial designs and their potentials and limitations to tackle these recognized molecular heterogeneity challenges. Regulatory hurdles, with respect to drug and companion diagnostic development and approval, are considered. Focus is on the ‘Expansion Platform Design Types I and II’, the latter demonstrated with a first example, ‘PANGEA: Personalized Anti-Neoplastics for Gastro-Esophageal Adenocarcinoma’. Applying integral medium-throughput genomic and proteomic assays along with

  5. Discovery Channel Telescope software progress report: addressing early commissioning and operations challenges

    NASA Astrophysics Data System (ADS)

    Lacasse, Michael; Lotz, Paul J.

    2014-07-01

    The Discovery Channel Telescope is a 4.3m astronomical research telescope in northern Arizona constructed through a partnership between Discovery Communications and Lowell Observatory. In transition from construction phase to commissioning and operations, we faced a variety of software challenges, both foreseen and unforeseen, and addressed those with a variety of solutions including, isolation of the control systems network, development of an Operations Log application, extension of the interface to instrumentation software, improvements to engineering data analysis, provisions to avoid failure modes, and enhanced user experience. We describe these solutions and present an overview of the current project status.

  6. Skill-mix in preventive dental practice - will it help address need in the future?

    PubMed Central

    2015-01-01

    Background Population health needs are changing. The levels of dental caries and periodontal disease across the population as a whole is falling. The proportion of adults with a functional dentition in many developed countries has increased substantially and edentulous rates have dropped to some of their lowest levels. Despite this, a pronounced social gradient still exists, many adults do not attend dental services regularly and disease in young children remains intransigent amongst the poorest. New challenges are emerging too as the growing number of older people, above sixty-five years of age, retain their teeth. Methods Ensuring “the right number of people with the right skills are in the right place at the right time to provide the right services to the right people” is critical for future dental service provision, both to meet the new challenges ahead and to ensure future services are cost-effective, efficient and reduce health-inequalities. Greater use of “skill-mix” models could have a substantial role in the future, as dentistry moves from a “cure” to a “care” culture. Discussion The provision of dental services in many countries currently adopts a “one-size-fits-all”, where the dentist is the main care-giver and the emphasis is on intervention. As needs change in the future, the whole of the dental team should be utilised to deliver primary, secondary and tertiary prevention in an integrated model. Growing evidence suggests that other members of the dental team are effective in providing care, but introducing this paradigm shift is not without its challenges. The provision of incentives within funding systems and social acceptability are amongst the key determinants in producing a service that is responsive to need, improves access and delivers equity. PMID:26391730

  7. Teaching Climate Change to Future Teachers Using 'Real' Data: Challenges and Opportunities (Invited)

    NASA Astrophysics Data System (ADS)

    Petcovic, H. L.; Barone, S.; Fulford, J.

    2013-12-01

    A climate-literate public is essential to resolving pressing problems related to global change. Future elementary teachers are a critical audience in climate and climate change education, as they will introduce children in early grades (USA grades K-8, children ages 5-14) to fundamentals of the climate system, natural and anthropogenic drivers of climate change, and impacts of global change on human and natural systems. Here we describe challenges we have encountered in teaching topics of the carbon cycle, greenhouse gases, past climate, recent anthropogenic change, and carbon footprints to future elementary teachers. We also describe how we have met (to varying degrees of success) these challenges in an introductory earth science course that is specifically designed for this audience. Two prominent challenges we have encountered are: the complex nature of the scientific content of climate change, and robust misconceptions held by our students about these topics. To address the first challenge, we attempt to adjust the scientific content to a level appropriate for future K-8 teachers, without sacrificing too much accuracy or critical detail. To address the second challenge, we explicitly discuss alternate conceptions of each topic. The use of authentic data sets can also address both of these challenges. Yet incorporating 'real' climate and paleoclimate data into the classroom poses still an additional challenge of instructional design. We use a variety of teaching approaches in our laboratory-based course including student-designed experiments, computer simulations, physical models, and authentic data sets. We have found that students strongly prefer the physical models and experiments, because these are 'hands-on' and perceived as easily adaptable to the K-8 classroom. Students often express dislike for activities that use authentic data sets (for example, an activity using graphs of CO2 and methane concentrations in Vostok ice cores), in particular because they

  8. The Role of Nanoscience and Nanotechnology in Addressing the World's Energy Challenges

    NASA Astrophysics Data System (ADS)

    Dickerson, James

    2014-03-01

    The Center for Functional Nanomaterials (CFN) at Brookhaven National Laboratory in the United States provides state-of-the-art capabilities for the fabrication and study of nanoscale materials, with an emphasis on atomic-level tailoring to achieve desired properties and functions. The CFN is a science-based user facility, simultaneously developing strong scientific programs while offering broad access to its capabilities and collaboration through an active user program. The overarching scientific theme of the CFN is the development and understanding of nanoscale materials that address the Nations' challenges in energy security, consistent with the Department of Energy mission. The CFN is one of five Nanoscale Science Research Centers (NSRCs) funded by the Office of Science of the United States Department of Energy. The CFN supports Brookhaven's goal of leadership in the development of advanced materials and processes for selected energy applications. In my presentation, I will highlight the role that the CFN, through its scientific staff and this scientific user community, is playing in addressing the world's energy challenges. I will focus on several trajectories of research that are being executed at CFN, including work on photovoltaics, novel nanostructured materials for catalysis, soft and biological materials, and our state-of-the-art electron microscopy and proximal probe microscopy facilities.

  9. Some strategies to address the challenges of collecting observational data in a busy clinical environment.

    PubMed

    Jackson, Debra; McDonald, Glenda; Luck, Lauretta; Waine, Melissa; Wilkes, Lesley

    2016-01-01

    Studies drawing on observational methods can provide vital data to enhance healthcare. However, collecting observational data in clinical settings is replete with challenges, particularly where multiple data-collecting observers are used. Observers collecting data require shared understanding and training to ensure data quality, and particularly, to confirm accurate and consistent identification, discrimination and recording of data. The aim of this paper is to describe strategies for preparing and supporting multiple researchers tasked with collecting observational data in a busy, and often unpredictable, hospital environment. We hope our insights might assist future researchers undertaking research in similar settings. PMID:27188039

  10. Epigenetics of Addiction: Current Knowledge, Challenges, and Future Directions.

    PubMed

    Cecil, Charlotte A M; Walton, Esther; Viding, Essi

    2016-09-01

    Addiction to psychoactive substances is a debilitating condition underpinned by the interplay of genetic and environmental factors. At present, a key challenge for research is to delineate how, at a molecular level, these influences become "biologically embedded," contributing to the onset and persistence of addictive behaviors. Recently, epigenetic processes that regulate gene expression have emerged as a potential mechanism of interest. In this commentary, we discuss the relevance of epigenetics to addiction research, starting with the current state of knowledge, what challenges we have yet to overcome, and what the future may hold in terms of research methodology and translational potential. PMID:27588525

  11. Exoskeletons and orthoses: classification, design challenges and future directions

    PubMed Central

    Herr, Hugh

    2009-01-01

    For over a century, technologists and scientists have actively sought the development of exoskeletons and orthoses designed to augment human economy, strength, and endurance. While there are still many challenges associated with exoskeletal and orthotic design that have yet to be perfected, the advances in the field have been truly impressive. In this commentary, I first classify exoskeletons and orthoses into devices that act in series and in parallel to a human limb, providing a few examples within each category. This classification is then followed by a discussion of major design challenges and future research directions critical to the field of exoskeletons and orthoses. PMID:19538735

  12. Challenges for a local service agency to address domestic violence -a case study from rural Indonesia.

    PubMed

    Hayati, Elli Nur; Emmelin, Maria; Eriksson, Malin

    2014-11-01

    Since the launch of a Zero Tolerance Policy in Indonesia, several policies to address domestic violence have been enacted. The obligation of local governments to establish service units for women survivors of domestic violence is one of them. Since domestic violence is a sensitive and complex issue in Indonesia it is important to understand how governmentally regulated services function in practice. This case study aimed to explore challenges faced by a local service agency in managing service provision for women survivors of domestic violence in rural Indonesia. Data from one focus group discussion (12 participants), four individual interviews, six short narratives, two days of participant observation, as well as archive reviews were collected. All data were analyzed using Grounded Theory Situational Analysis. The major challenge faced by the local agency was the low priority that was given them by the local authorities, mirrored also in low involvement by the assigned volunteers in the daily service. The study also identified a gap between the socio-cultural arena and the law & policy arena that needs to be bridged to avoid that the two arenas address domestic violence in a contradictory way. Budget allocation to support the sustainability of the daily routines of service agencies has to be given priority. There is also a need for careful considerations regarding the composition of personnel involved within daily management of service agencies addressing domestic violence. To bridge the gap between the legal systems and traditional cultural values, culturally adjusted alternative justice systems could be developed to increase women's access to legal support. PMID:25363105

  13. STaRRS in Yellowstone: Addressing Challenges Facing Student-Teacher-Scientist Partnerships

    NASA Astrophysics Data System (ADS)

    Houseal, A.; Gallagher, R.; Fuhrmann, B.; Sanford, R.

    2010-12-01

    The literature outlines many challenges faced by Student-Teacher-Scientist Partnerships (STSPs) including cultural differences between the scientific research and education communities. For example, shared vocabulary terms with dissimilar definitions can create communication problems. Other issues include accuracy in data collection, meeting the needs of a very diverse group of partners, connecting students with research science in a meaningful way, and maintaining the infrastructure necessary to develop and maintain these partnerships. Additionally, evidence, other than anecdotal, of the success of these partnerships is limited, especially as school year and research cycles are often on different schedules or have very different goals. Students, Teachers, and Rangers & Research Scientists: Investigating Systems at Mammoth Hot Springs in Yellowstone National Park (STaRRS) was an STSP developed to address some of these challenges, model some solutions within an STSP, and identify some possible outcomes for participating teachers and their students. Three strategies used to address some of these challenges that will be discussed briefly in this presentation include: (a) embedding the STSP in an already existing National Park Service environmental education program; (b) development of three types of research activities connecting teachers, students, and scientists to the research, and (c) a professional development (PD) model that included all partners in an on-going year-long process. Results from an accompanying research study will also be presented. Using a pretest-intervention-posttest design, this study revealed significant changes in attitude regarding science and scientists of participating STaRRS teachers. Student data gathered using a quasi-experimental pretest-intervention-posttest treatment and comparison group design also demonstrated significant changes in their attitudes and gains in earth science content knowledge.

  14. Time for a change: addressing R&D and commercialization challenges for antibacterials

    PubMed Central

    Payne, David J.; Miller, Linda Federici; Findlay, David; Anderson, James; Marks, Lynn

    2015-01-01

    The antibacterial therapeutic area has been described as the perfect storm. Resistance is increasing to the point that our hospitals encounter patients infected with untreatable pathogens, the overall industry pipeline is described as dry and most multinational pharmaceutical companies have withdrawn from the area. Major contributing factors to the declining antibacterial industry pipeline include scientific challenges, clinical/regulatory hurdles and low return on investment. This paper examines these challenges and proposes approaches to address them. There is a need for a broader scientific agenda to explore new approaches to discover and develop antibacterial agents. Additionally, ideas of how industry and academia could be better integrated will be presented. While promising progress in the regulatory environment has been made, more streamlined regulatory paths are still required and the solutions will lie in global harmonization and clearly defined guidance. Creating the right incentives for antibacterial research and development is critical and a new commercial model for antibacterial agents will be proposed. One key solution to help resolve both the problem of antimicrobial resistance (AMR) and lack of new drug development are rapid, cost-effective, accurate point of care diagnostics that will transform antibacterial prescribing and enable more cost-effective and efficient antibacterial clinical trials. The challenges of AMR are too great for any one group to resolve and success will require leadership and partnerships among academia, industry and governments globally. PMID:25918443

  15. Time for a change: addressing R&D and commercialization challenges for antibacterials.

    PubMed

    Payne, David J; Miller, Linda Federici; Findlay, David; Anderson, James; Marks, Lynn

    2015-06-01

    The antibacterial therapeutic area has been described as the perfect storm. Resistance is increasing to the point that our hospitals encounter patients infected with untreatable pathogens, the overall industry pipeline is described as dry and most multinational pharmaceutical companies have withdrawn from the area. Major contributing factors to the declining antibacterial industry pipeline include scientific challenges, clinical/regulatory hurdles and low return on investment. This paper examines these challenges and proposes approaches to address them. There is a need for a broader scientific agenda to explore new approaches to discover and develop antibacterial agents. Additionally, ideas of how industry and academia could be better integrated will be presented. While promising progress in the regulatory environment has been made, more streamlined regulatory paths are still required and the solutions will lie in global harmonization and clearly defined guidance. Creating the right incentives for antibacterial research and development is critical and a new commercial model for antibacterial agents will be proposed. One key solution to help resolve both the problem of antimicrobial resistance (AMR) and lack of new drug development are rapid, cost-effective, accurate point of care diagnostics that will transform antibacterial prescribing and enable more cost-effective and efficient antibacterial clinical trials. The challenges of AMR are too great for any one group to resolve and success will require leadership and partnerships among academia, industry and governments globally. PMID:25918443

  16. Meeting the current and future challenges of oncology drug development

    PubMed Central

    Howie, Moira; Oliver, Kathy; Timoney, Angela; McVie, Gordon

    2013-01-01

    This breakout session highlighted four distinct perspectives from leading individuals within patient advocacy, industry, an appraisal committee and physicians on the future and challenges faced by targeted therapy in HTA evaluation. Bringing together leaders from key stakeholders in the process, it gave participants the opportunity to examine how the same HTA evaluation process is interpreted from multiple perspectives. The presentation of an industry supported “Six Nation Public Opinion Survey of Cancer Knowledge and Attitudes” provided detailed insight into how the general public, patients and caregivers view cancer alongside various available and possible future therapies. An interactive ‘perspectives activity’ session provided all participants with an opportunity to think through and discuss the HTA process, and its challenges, from the four distinct positions involved. We declare that we have no conflicts of interest. PMID:24883090

  17. The Hubble Space Telescope servicing missions: Past, present, and future operational challenges

    NASA Technical Reports Server (NTRS)

    Ochs, William R.; Barbehenn, George M.; Crabb, William G.

    1996-01-01

    The Hubble Space Telescope was designed to be serviced by the Space Shuttle to upgrade systems, replace failed components and boost the telescope into higher orbits. There exists many operational challenges that must be addressed in preparation for the execution of a servicing mission, including technical and managerial issues. The operational challenges faced by the Hubble operations and ground system project for the support of the first servicing mission and future servicing missions, are considered. The emphasis is on those areas that helped ensure the success of the mission, including training, testing and contingency planning.

  18. Megacities and Large Urban Complexes - WMO Role in Addressing Challenges and Opportunities

    NASA Astrophysics Data System (ADS)

    Terblanche, Deon; Jalkanen, Liisa

    2013-04-01

    Megacities and Large Urban Complexes - WMO Role in Addressing Challenges and Opportunities Deon E. Terblanche and Liisa Jalkanen dterblanche@wmo.int ljalkanen@wmo.int World Meteorological Organization, Geneva, Switzerland The 21st Century could amongst others, become known as the century in which our species has evolved from Homo sapiens to Homo urbanus. By now the urban population has surpassed the rural population and the rate of urbanization will continue at such a pace that by 2050 urban dwellers could outnumber their rural counterpart by more than two to one. Most of this growth in urban population will occur in developing countries and along coastal areas. Urbanization is to a large extent the outcome of humans seeking a better life through improved opportunities presented by high-density communities. Megacities and large urban complexes provide more job opportunities and social structures, better transport and communication links and a relative abundance of physical goods and services when compared to most rural areas. Unfortunately these urban complexes also present numerous social and environmental challenges. Urban areas differ from their surroundings by morphology, population density, and with high concentration of industrial activities, energy consumption and transport. They also pose unique challenges to atmospheric modelling and monitoring and create a multi-disciplinary spectrum of potential threats, including air pollution, which need to be addressed in an integrated way. These areas are also vulnerable to the changing climate and its implications to sea-level and extreme events, air quality and related health impacts. Many urban activities are significantly impacted by weather events that would not be considered to be of high impact in less densely populated areas. For instance, moderate precipitation events can cause flooding and landslides as modified urban catchments generally have higher run-off to rainfall ratios than their more pristine rural

  19. Modelling biological evolution: recent progress, current challenges and future direction

    PubMed Central

    Morozov, Andrew

    2013-01-01

    Mathematical modelling is widely recognized as a powerful and convenient theoretical tool for investigating various aspects of biological evolution and explaining the existing genetic complexity of the real world. It is increasingly apparent that understanding the key mechanisms involved in the processes of species biodiversity, natural selection and inheritance, patterns of animal behaviour and coevolution of species in complex ecological systems is simply impossible by means of laboratory experiments and field observations alone. Mathematical models are so important because they provide wide-ranging exploration of the problem without a need for experiments with biological systems—which are usually expensive, often require long time and can be potentially dangerous. However, as the number of theoretical works on modelling biological evolution is constantly accelerating each year as different mathematical frameworks and various aspects of evolutionary problems are considered, it is often hard to avoid getting lost in such an immense flux of publications. The aim of this issue of Interface Focus is to provide a useful guide to important recent findings in some key areas in modelling biological evolution, to refine the existing challenges and to outline possible future directions. In particular, the following topics are addressed here by world-leading experts in the modelling of evolution: (i) the origins of biodiversity observed in ecosystems and communities; (ii) evolution of decision-making by animals and the optimal strategy of populations; (iii) links between evolutionary and ecological processes across different time scales; (iv) quantification of biological information in evolutionary models; and (v) linking theoretical models with empirical data. Most of the works presented here are in fact contributed papers from the international conference ‘Modelling Biological Evolution’ (MBE 2013), which took place in Leicester, UK, in May 2013 and brought together

  20. Sleep medicine in Saudi Arabia: Current problems and future challenges

    PubMed Central

    BaHammam, Ahmed S.

    2011-01-01

    Sleep medicine is a relatively new specialty in the medical community. The practice of sleep medicine in Saudi Arabia (KSA) began in the mid to late nineties. Since its inception, the specialty has grown, and the number of specialists has increased. Nevertheless, sleep medicine is still underdeveloped in the KSA, particularly in the areas of clinical service, education, training and research. Based on available data, it appears that sleep disorders are prevalent among Saudis, and the demand for sleep medicine service is expected to rise significantly in the near future. A number of obstacles have been defined that hinder the progress of the specialty, including a lack of trained technicians, specialists and funding. Awareness about sleep disorders and their serious consequences is low among health care workers, health care authorities, insurance companies and the general public. A major challenge for the future is penetrating the educational system at all levels to demonstrate the high prevalence and serious consequences of sleep disorders. To attain adequate numbers of staff and facilities, the education and training of health care professionals at the level of sleep medicine specialists and sleep technologists is another important challenge that faces the specialty. This review discusses the current position of sleep medicine as a specialty in the KSA and the expected challenges of the future. In addition, it will guide clinicians interested in setting up new sleep medicine services in the KSA or other developing countries through the potential obstacles that may face them in this endeavor. PMID:21264164

  1. Nonclinical safety testing of biopharmaceuticals--Addressing current challenges of these novel and emerging therapies.

    PubMed

    Brennan, Frank R; Baumann, Andreas; Blaich, Guenter; de Haan, Lolke; Fagg, Rajni; Kiessling, Andrea; Kronenberg, Sven; Locher, Mathias; Milton, Mark; Tibbitts, Jay; Ulrich, Peter; Weir, Lucinda

    2015-10-01

    Non-clinical safety testing of biopharmaceuticals can present significant challenges to human risk assessment with these often innovative and complex drugs. Hot Topics in this field were discussed recently at the 4th Annual European Biosafe General Membership meeting. In this feature article, the presentations and subsequent discussions from the main sessions are summarized. The topics covered include: (i) wanted versus unwanted immune activation, (ii) bi-specific protein scaffolds, (iii) use of Pharmacokinetic (PK)/Pharmacodynamic (PD) data to impact/optimize toxicology study design, (iv) cytokine release and challenges to human translation (v) safety testing of cell and gene therapies including chimeric antigen receptor T (CAR-T) cells and retroviral vectors and (vi) biopharmaceutical development strategies encompassing a range of diverse topics including optimizing entry of monoclonal antibodies (mAbs) into the brain, safety testing of therapeutic vaccines, non-clinical testing of biosimilars, infection in toxicology studies with immunomodulators and challenges to human risk assessment, maternal and infant anti-drug antibody (ADA) development and impact in non-human primate (NHP) developmental toxicity studies, and a summary of an NC3Rs workshop on the future vision for non-clinical safety assessment of biopharmaceuticals. PMID:26219199

  2. Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges

    PubMed Central

    Amarasingham, Ruben; Audet, Anne-Marie J.; Bates, David W.; Glenn Cohen, I.; Entwistle, Martin; Escobar, G. J.; Liu, Vincent; Etheredge, Lynn; Lo, Bernard; Ohno-Machado, Lucila; Ram, Sudha; Saria, Suchi; Schilling, Lisa M.; Shahi, Anand; Stewart, Walter F.; Steyerberg, Ewout W.; Xie, Bin

    2016-01-01

    Context: The recent explosion in available electronic health record (EHR) data is motivating a rapid expansion of electronic health care predictive analytic (e-HPA) applications, defined as the use of electronic algorithms that forecast clinical events in real time with the intent to improve patient outcomes and reduce costs. There is an urgent need for a systematic framework to guide the development and application of e-HPA to ensure that the field develops in a scientifically sound, ethical, and efficient manner. Objectives: Building upon earlier frameworks of model development and utilization, we identify the emerging opportunities and challenges of e-HPA, propose a framework that enables us to realize these opportunities, address these challenges, and motivate e-HPA stakeholders to both adopt and continuously refine the framework as the applications of e-HPA emerge. Methods: To achieve these objectives, 17 experts with diverse expertise including methodology, ethics, legal, regulation, and health care delivery systems were assembled to identify emerging opportunities and challenges of e-HPA and to propose a framework to guide the development and application of e-HPA. Findings: The framework proposed by the panel includes three key domains where e-HPA differs qualitatively from earlier generations of models and algorithms (Data Barriers, Transparency, and Ethics) and areas where current frameworks are insufficient to address the emerging opportunities and challenges of e-HPA (Regulation and Certification; and Education and Training). The following list of recommendations summarizes the key points of the framework: Data Barriers: Establish mechanisms within the scientific community to support data sharing for predictive model development and testing.Transparency: Set standards around e-HPA validation based on principles of scientific transparency and reproducibility.Ethics: Develop both individual-centered and society-centered risk-benefit approaches to evaluate

  3. Future Earth -- New Approaches to address Climate Change and Sustainability in the MENA Region

    NASA Astrophysics Data System (ADS)

    Lange, Manfred; Abu Alhaija, Rana

    2016-04-01

    Interactions and feedbacks between rapidly increasing multiple pressures on water, energy and food security drive social-ecological systems at multiple scales towards critical thresholds in countries of the Eastern Mediterranean, the Middle East and North Africa (MENA Region). These pressures, including climate change, the growing demand on resources and resource degradation, urbanization and globalization, cause unprecedented challenges for countries and communities in the region. Responding to these challenges requires integrated science and a closer relationship with policy makers and stakeholders. Future Earth has been designed to respond to these urgent needs. In order to pursue such objectives, Future Earth is becoming the host organization for some 23 programs that were previously run under four global environmental change programmes, DIVERSITAS, the International Geosphere-Biosphere Programme (IGBP), the International Human Dimensions Programme (IHDP) and the World Climate Research Programme (WCRP). Some further projects arose out of the Earth System Science Partnership (ESSP). It thus brings together a wide spectrum of expertise and knowledge that will be instrumental in tackling urgent problems in the MENA region and the wider Mediterranean Basin. Future Earth is being administered by a globally distributed secretariat that also includes a series of Regional Centers, which will be the nuclei for the development of new regional networks. The Cyprus Institute in Nicosia, Cyprus (CyI; www.cyi.ac.cy) is hosting the Regional Center for the MENA Region. The CyI is a non-profit research and post-graduate education institution with a strong scientific and technological orientation and a distinctive regional, Eastern Mediterranean scope. Cyprus at the crossroads of three continents and open to all nations in the region provides excellent conditions for advancing the research agenda of Future Earth in the MENA Region. Given the recent and ongoing major political

  4. Addressing the Challenges of Hepatitis C Virus Resistance and Treatment Failure

    PubMed Central

    Colpitts, Che C.; Baumert, Thomas F.

    2016-01-01

    Chronic hepatitis C is a major cause of chronic liver disease, including liver cirrhosis and hepatocellular carcinoma. The development of direct-acting antivirals (DAAs) revolutionized hepatitis C virus (HCV) treatment by offering genuine prospects for the first comprehensive cure of a chronic viral infection in humans. While antiviral resistance is a significant limitation for interferon-based therapies, resistance and treatment failure still appear to be present in a small fraction of patients even in state-of-the-art DAA combination therapies. Therefore, treatment failure and resistance still remain a clinical challenge for the management of patients not responding to DAAs. In this special issue of Viruses on HCV drug resistance, mechanisms of antiviral resistance for different classes of antiviral drugs are described. Furthermore, the detection and monitoring of resistance in clinical practice, the clinical impact of resistance in different patient groups and strategies to prevent and address resistance and treatment failure using complementary antiviral strategies are reviewed. PMID:27537906

  5. Disaster response and people experiencing homelessness: Addressing challenges of a population with limited resources.

    PubMed

    Wexler, Bryan; Smith, Mary-Elise

    2015-01-01

    In this article the authors provide an overview of some issues that inhibit disaster planning and response for people experiencing homelessness and discuss the planning process conducted for this population in Worcester, MA. People experiencing homelessness face numerous challenges in preparing for disasters both natural and human caused. Similarly, providers attempting to aid these individuals must recognize and overcome various factors that hamper efforts to provide assistance. People experiencing homelessness lack the general resources many in the United States take for granted, including food, shelter, communication methods, and transportation. The population also has an increased prevalence of medical and psychiatric conditions. These factors amplify the typical difficulties in preparedness, communication, sheltering, and training for disasters. With these principles in mind, the authors reviewed the literature for best practices, identified potential stakeholders, and developed an annex to help address organization and delivery of care to those experiencing homelessness during a disaster. PMID:26150363

  6. Geriatric Telemedicine: Background and Evidence for Telemedicine as a Way to Address the Challenges of Geriatrics

    PubMed Central

    2015-01-01

    Objectives The global population of elderly people is increasing at a remarkable rate, which may be expected to continue for some time. Older patients require more care, and with the current model of care delivery, the costs may be expected to rise, although higher cost is unsustainable. For this reason, a new pattern of practice is needed. Telemedicine will be presented as a highly effective and necessary tool in geriatrics. Methods This review will present some of the background and evidence for telemedicine as a way to address the challenges of geriatrics through geriatric telemedicine. Some of the evidence for the value of telemedicine as a tool for physicians and healthcare systems is presented. Results Telemedicine offers many means to address the problems of geriatric care in creative ways. The use of electronic medicine, telecommunications, and information management has now found its way into the very fabric of health care. The use of telemedicine is a fait accompli in much of the world, and it continues to have an increasing role deeply imbedded in our electronic practices coupled with social media. Conclusions The evidence for successful incorporation of telemedicine into practice is abundant and continues to accrue. This is a great opportunity for medical practice to evolve to new levels of engagement with patients and new levels of attainment in terms of quality care. PMID:26618027

  7. Facilitators, challenges, and collaborative activities in faith and health partnerships to address health disparities.

    PubMed

    Kegler, Michelle C; Hall, Sarah M; Kiser, Mimi

    2010-10-01

    Interest in partnering with faith-based organizations (FBOs) to address health disparities has grown in recent years. Yet relatively little is known about these types of partnerships. As part of an evaluation of the Institute for Faith and Public Health Collaborations, representatives of 34 faith-health teams (n = 61) completed semi-structured interviews. Interviews were tape recorded, transcribed, and coded by two members of the evaluation team to identify themes. Major facilitators to faith-health collaborative work were passion and commitment, importance of FBOs in communities, favorable political climate, support from community and faith leaders, diversity of teams, and mutual trust and respect. Barriers unique to faith and health collaboration included discomfort with FBOs, distrust of either health agencies or FBOs, diversity within faith communities, different agendas, separation of church and state, and the lack of a common language. Findings suggest that faith-health partnerships face unique challenges but are capable of aligning resources to address health disparities. PMID:20696884

  8. Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals

    PubMed Central

    Dugas, Tammy R.; Lomnicki, Slawomir; Cormier, Stephania A.; Dellinger, Barry; Reams, Margaret

    2016-01-01

    Airborne fine and ultrafine particulate matter (PM) are often generated through widely-used thermal processes such as the combustion of fuels or the thermal decomposition of waste. Residents near Superfund sites are exposed to PM through the inhalation of windblown dust, ingestion of soil and sediments, and inhalation of emissions from the on-site thermal treatment of contaminated soils. Epidemiological evidence supports a link between exposure to airborne PM and an increased risk of cardiovascular and pulmonary diseases. It is well-known that during combustion processes, incomplete combustion can lead to the production of organic pollutants that can adsorb to the surface of PM. Recent studies have demonstrated that their interaction with metal centers can lead to the generation of a surface stabilized metal-radical complex capable of redox cycling to produce ROS. Moreover, these free radicals can persist in the environment, hence their designation as Environmentally Persistent Free Radicals (EPFR). EPFR has been demonstrated in both ambient air PM2.5 (diameter < 2.5 µm) and in PM from a variety of combustion sources. Thus, low-temperature, thermal treatment of soils can potentially increase the concentration of EPFR in areas in and around Superfund sites. In this review, we will outline the evidence to date supporting EPFR formation and its environmental significance. Furthermore, we will address the lack of methodologies for specifically addressing its risk assessment and challenges associated with regulating this new, emerging contaminant. PMID:27338429

  9. Becoming a vaccine champion: evidence-based interventions to address the challenges of vaccination.

    PubMed

    Temoka, Erick

    2013-01-01

    The incidence, prevalence, morbidity and mortality rates of vaccine-preventable diseases have decreased drastically since the advent of modern vaccination by Edward Jenner at the end of the 18th century. In recent years, however, a growing number of parents have been refusing or delaying vaccination for their children for socioeconomical, medical, religious and/or philosophical reasons. This has resulted in a loss of herd immunity that has caused a resurgence of many infectious diseases. This article describes evidence-based methods by which a pediatric clinic can become a vaccine champion by aiming at vaccination rates of 100 percent. This goal can be attained by a team effort that addresses the challenges of vaccination by using every visit as a chance to vaccinate, educate, address the fears and the concerns of the parents and provide articles and other written documentations on the benefits and side effects of vaccines. A standardized system that identifies and tracks patients who need vaccines is also essential to find those who are seldom brought to medical attention. A consistent and systematic use of these evidence-based methods by a dedicated staff is essential to attain vaccination rates close to 100 percent. PMID:23444594

  10. Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals.

    PubMed

    Dugas, Tammy R; Lomnicki, Slawomir; Cormier, Stephania A; Dellinger, Barry; Reams, Margaret

    2016-01-01

    Airborne fine and ultrafine particulate matter (PM) are often generated through widely-used thermal processes such as the combustion of fuels or the thermal decomposition of waste. Residents near Superfund sites are exposed to PM through the inhalation of windblown dust, ingestion of soil and sediments, and inhalation of emissions from the on-site thermal treatment of contaminated soils. Epidemiological evidence supports a link between exposure to airborne PM and an increased risk of cardiovascular and pulmonary diseases. It is well-known that during combustion processes, incomplete combustion can lead to the production of organic pollutants that can adsorb to the surface of PM. Recent studies have demonstrated that their interaction with metal centers can lead to the generation of a surface stabilized metal-radical complex capable of redox cycling to produce ROS. Moreover, these free radicals can persist in the environment, hence their designation as Environmentally Persistent Free Radicals (EPFR). EPFR has been demonstrated in both ambient air PM2.5 (diameter < 2.5 µm) and in PM from a variety of combustion sources. Thus, low-temperature, thermal treatment of soils can potentially increase the concentration of EPFR in areas in and around Superfund sites. In this review, we will outline the evidence to date supporting EPFR formation and its environmental significance. Furthermore, we will address the lack of methodologies for specifically addressing its risk assessment and challenges associated with regulating this new, emerging contaminant. PMID:27338429

  11. Integrated Strategy to Address Hanford’s Deep Vadose Zone Remediation Challenges

    SciTech Connect

    Triplett, Mark B.; Freshley, Mark D.; Truex, Michael J.; Wellman, Dawn M.; Gerdes, Kurt D.; Charboneau, Briant L.; Morse, John G.; Lober, Robert W.; Chronister, Glen B.

    2010-10-03

    A vast majority of Hanford’s remaining in-ground contaminants reside in the vadose zone of the Central Plateau, where reprocessing operations occurred. The vadose zone is comprised of about 75 meters of water-unsaturated sediments above groundwater. These contaminants have, and continue to release into groundwater that discharges to the Columbia River. If left untreated, these contaminants could remain a threat for centuries. Much of this contamination resides deep in the vadose zone, below the effective depth of tradition surface remedy influence. In 2008, the Department of Energy initiated deep vadose zone treatability testing to seek remedies for technetium-99 and uranium contamination. These tests include the application of desiccation for technetium-99 and reactive gas technologies for uranium. To complement these efforts, the Department of Energy has initiated a “defense-in-depth” approach to address the unique challenges for characterization and remediation of the deep vadose zone. This defense-in-depth approach will implement multiple approaches to understand and control contaminant flux from the deep vadose zone to the groundwater. Among these approaches is an increased investment in science and technology solutions to resolve deep vadose zone challenges including characterization, prediction, remediation, and monitoring.

  12. Large system change challenges: addressing complex critical issues in linked physical and social domains

    NASA Astrophysics Data System (ADS)

    Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna

    2015-04-01

    Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways

  13. Future challenges for nuclear power plant development research, and for radiological protection sciences.

    PubMed

    Lazo, Edward

    2007-11-01

    The promise of the future shines brightly for nuclear energy technology and production, yet also holds many challenges. Focus on new reactor designs is currently aiming at what is termed the fourth generation of reactors, which will come into operation after 2030. The 10 countries participating in the Generation-IV International Forum to develop the new generation of reactors have designated six reactor designs that will be studied. This paper will briefly discuss some of these challenges in new reactor designs in general. In addition to the challenges posed by new reactor designs, radiation protection is also faced with a series of challenges for the future. These are borne from experience with the implementation of the current system of radiological protection, from the evolution of radiation biological research, and from changes in society in the area of radiological risk assessment and management. This paper will address all of these emerging challenges, and point towards approaches to resolve them in the future. PMID:18049234

  14. Ethics in occupational health: deliberations of an international workgroup addressing challenges in an African context

    PubMed Central

    2014-01-01

    Background International codes of ethics play an important role in guiding professional practice in developing countries. In the occupational health setting, codes developed by international agencies have substantial import on protecting working populations from harm. This is particularly so under globalisation which has transformed processes of production in fundamental ways across the globe. As part of the process of revising the Ethical Code of the International Commission on Occupational Health, an Africa Working Group addressed key challenges for the relevance and cogency of an ethical code in occupational health for an African context through an iterative consultative process. Discussion Firstly, even in the absence of strong legal systems of enforcement, and notwithstanding the value of legal institutionalisation of ethical codes, guidelines alone may offer advantageous routes to enhancing ethical practice in occupational health. Secondly, globalisation has particularly impacted on health and safety at workplaces in Africa, challenging occupational health professionals to be sensitive to, and actively redress imbalance of power. Thirdly, the different ways in which vulnerability is exemplified in the workplace in Africa often places the occupational health professional in invidious positions of Dual Loyalty. Fourth, the particular cultural emphasis in traditional African societies on collective responsibilities within the community impacts directly on how consent should be sought in occupational health practice, and how stigma should be dealt with, balancing individual autonomy with ideas of personhood that are more collective as in the African philosophy of ubuntu. To address stigma, practitioners need to be additionally sensitive to how power imbalances at the workplace intersect with traditional cultural norms related to solidarity. Lastly, particularly in the African context, the inseparability of workplace and community means that efforts to address

  15. Water management: Current and future challenges and research directions

    NASA Astrophysics Data System (ADS)

    Cosgrove, William J.; Loucks, Daniel P.

    2015-06-01

    Water distinguishes our planet compared to all the others we know about. While the global supply of available freshwater is more than adequate to meet all current and foreseeable water demands, its spatial and temporal distributions are not. There are many regions where our freshwater resources are inadequate to meet domestic, economic development and environmental needs. In such regions, the lack of adequate clean water to meet human drinking water and sanitation needs is indeed a constraint on human health and productivity and hence on economic development as well as on the maintenance of a clean environment and healthy ecosystems. All of us involved in research must find ways to remove these constraints. We face multiple challenges in doing that, especially given a changing and uncertain future climate, and a rapidly growing population that is driving increased social and economic development, globalization, and urbanization. How best to meet these challenges requires research in all aspects of water management. Since 1965, the journal Water Resources Research has played an important role in reporting and disseminating current research related to managing the quantity and quality and cost of this resource. This paper identifies the issues facing water managers today and future research needed to better inform those who strive to create a more sustainable and desirable future.

  16. Economic concepts to address future water supply-demand imbalances in Iran, Morocco and Saudi Arabia

    NASA Astrophysics Data System (ADS)

    Hellegers, Petra; Immerzeel, Walter; Droogers, Peter

    2013-10-01

    In Middle East and North Africa (MENA) countries, renewable groundwater and surface water supply are limited while demand for water is growing rapidly. Climate change is expected to increase water demand even further. The main aim of this paper is to evaluate the water supply-demand imbalances in Iran, Morocco and Saudi Arabia in 2040-2050 under dry, average and wet climate change projections and to show on the basis of the marginal cost and marginal value of water the optimum mix of supply-side and demand-side adjustments to address the imbalance. A hydrological model has been used to estimate the water supply-demand imbalance. Water supply and demand curves have been used to explore for which (marginal value of) water usage the marginal cost of supply-enhancement becomes too expensive. The results indicate that in the future in all cases, except in Iran under the wet climate projection, the quantity of water demanded has to be reduced considerably to address the imbalance, which is indeed what is currently happening already.

  17. Future Chances and Challenges for Near Surface Geophysics

    NASA Astrophysics Data System (ADS)

    Noell, U.; Meyer, U.

    2011-12-01

    Near surface geophysics provides information from global to local scale: a) Standardized geophysical observations are utilized e.g. in risk management frameworks beyond the national level a) Specific tasks in local or regional frameworks as mine flooding or ground water recharge monitoring are required. Either way, near surface geophysics is connected more than ever to technical problems and thus is vastly adopted by engineering. This is a chance and challenge at the same time. The chance is to make near surface geophysics more useful in applied and practical issues, the challenge is to develop new profiles and research directions. Recent satellite earth observation missions have much enhanced capabilities to observe near surface features and changes but generally very limited penetration. Near surface geophysics can bridge the gap between surface characterization and subsurface structures. Subsurface structures as aquifer systems, layering, deposits and mineralization can be determined by non-invasive near surface geophysics. A special challenge here is the enhanced interpretation of the physical data combined with an improved understanding of complex subsurface processes. Moreover, the limits of the interpretation and the measurements need to be quantified. Another future challenge is to gain a better and reliable understanding of soil - water cycles and gaseous flows via near surface geophysics. New methods and techniques that did not seem feasible in the past must reviewed whilst technology developed. This includes squids for magnetics and electromagnetics applications, nuclear magnetic resonance methods etc.

  18. Accelerator Challenges and Opportunities for Future Neutrino Experiments

    SciTech Connect

    Zisman, Michael S

    2010-12-24

    There are three types of future neutrino facilities currently under study, one based on decays of stored beta-unstable ion beams (?Beta Beams?), one based on decays of stored muon beams (?Neutrino Factory?), and one based on the decays of an intense pion beam (?Superbeam?). In this paper we discuss the challenges each design team must face and the R&D being carried out to turn those challenges into technical opportunities. A new program, the Muon Accelerator Program, has begun in the U.S. to carry out the R&D for muon-based facilities, including both the Neutrino Factory and, as its ultimate goal, a Muon Collider. The goals of this program will be briefly described.

  19. Arrhythmogenic KCNE gene variants: current knowledge and future challenges

    PubMed Central

    Crump, Shawn M.; Abbott, Geoffrey W.

    2014-01-01

    There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode either ion channel pore-forming subunits or proteins that regulate aspects of ion channel biology such as function, trafficking, and localization. The human KCNE gene family comprises five potassium channel regulatory subunits, sequence variants in each of which are associated with cardiac arrhythmias. KCNE gene products exhibit promiscuous partnering and in some cases ubiquitous expression, hampering efforts to unequivocally correlate each gene to specific native potassium currents. Likewise, deducing the molecular etiology of cardiac arrhythmias in individuals harboring rare KCNE gene variants, or more common KCNE polymorphisms, can be challenging. In this review we provide an update on putative arrhythmia-causing KCNE gene variants, and discuss current thinking and future challenges in the study of molecular mechanisms of KCNE-associated cardiac rhythm disturbances. PMID:24478792

  20. Arrhythmogenic KCNE gene variants: current knowledge and future challenges.

    PubMed

    Crump, Shawn M; Abbott, Geoffrey W

    2014-01-01

    There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode either ion channel pore-forming subunits or proteins that regulate aspects of ion channel biology such as function, trafficking, and localization. The human KCNE gene family comprises five potassium channel regulatory subunits, sequence variants in each of which are associated with cardiac arrhythmias. KCNE gene products exhibit promiscuous partnering and in some cases ubiquitous expression, hampering efforts to unequivocally correlate each gene to specific native potassium currents. Likewise, deducing the molecular etiology of cardiac arrhythmias in individuals harboring rare KCNE gene variants, or more common KCNE polymorphisms, can be challenging. In this review we provide an update on putative arrhythmia-causing KCNE gene variants, and discuss current thinking and future challenges in the study of molecular mechanisms of KCNE-associated cardiac rhythm disturbances. PMID:24478792

  1. Adverse rotorcraft pilot couplings—Past, present and future challenges

    NASA Astrophysics Data System (ADS)

    Pavel, Marilena D.; Jump, Michael; Dang-Vu, Binh; Masarati, Pierangelo; Gennaretti, Massimo; Ionita, Achim; Zaichik, Larisa; Smaili, Hafid; Quaranta, Giuseppe; Yilmaz, Deniz; Jones, Michael; Serafini, Jacopo; Malecki, Jacek

    2013-10-01

    Fixed and rotary wing pilots alike are familiar with potential instabilities or with annoying limit cycle oscillations that arise from the effort of controlling aircraft with high response actuation systems. Understanding, predicting and suppressing these inadvertent and sustained aircraft oscillations, known as aircraft (rotorcraft)-pilot couplings (A/RPCs) is a challenging problem for the designers. The goal of the present paper is to give an overview on the state-of-the-art in RPC problem, underlining the future challenges in this field. It is shown that, exactly as in the case of fixed wing APCs, RPCs existed from the beginning of rotorcraft development and that the problem of eliminating them is not yet solved: the current rotorcraft modelling for RPC analysis is rather limited to the particular case analysed and there is a lack of quantitative pilot behavioural models to analyse RPCs. The paper underlines the importance of involuntary pilot control actions, generally attributed to biodynamic couplings in predicting RPCs in rotorcraft. It is also shown that recent experiences demonstrate that modern rotorcraft seem to embed tendencies predisposing the flight control system FCS system towards dangerous RPCs. As the level of automation is likely to increase in future designs, extending to smaller aircraft and to different kinds of operation, the consequences of the pilot ‘fighting’ the FCS system and inducing A/RPCs needs to be eradicated. In Europe, the ARISTOTEL project (2010-2013) has been launched with the aim of understanding and predicting modern aircraft's susceptibility to A/RPC. The present paper gives an overview of future challenges to be solved for RPC-free design and some new solutions herein.

  2. Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs

    PubMed Central

    Ray, Paresh Chandra; Yu, Hongtao; Fu, Peter P.

    2010-01-01

    Nanotechnology has gained a great deal of public interest due to the needs and applications of nanomaterials in many areas of human endeavors including industry, agriculture, business, medicine and public health. Environmental exposure to nanomaterials is inevitable as nanomaterials become part of our daily life, and as a result, nanotoxicity research is gaining attention. This review presents a summary of recent research efforts on fate, behavior and toxicity of different classes of nanomaterials in the environment. A critical evaluation of challenges and future needs for the safe environmental nanotechnology has been discussed. PMID:19204862

  3. Crab cavities: Past, present, and future of a challenging device

    SciTech Connect

    Wu, Q.

    2015-05-03

    In two-ring facilities operating with a crossing-angle collision scheme, luminosity can be limited due to an incomplete overlapping of the colliding bunches. Crab cavities then are introduced to restore head-on collisions by providing the destined opposite deflection to the head and tail of the bunch. An increase in luminosity was demonstrated at KEKB with global crab-crossing, while the Large Hardron Collider (LHC) at CERN currently is designing local crab crossing for the Hi-Lumi upgrade. Future colliders may investigate both approaches. In this paper, we review the challenges in the technology, and the implementation of crab cavities, while discussing experience in earlier colliders, ongoing R&D, and proposed implementations for future facilities, such as HiLumi-LHC, CERN’s compact linear collider (CLIC), the international linear collider (ILC), and the electron-ion collider under design at BNL (eRHIC).

  4. Project T.A.C.K.L.E. (Together, Addressing the Challenges of Knowledge and Literacy for Employees). Evaluation Report.

    ERIC Educational Resources Information Center

    General Motors Corp., Detroit, MI.

    Project TACKLE (Together, Addressing the Challenge of Knowledge and Literacy for Employees) was a cooperative project, jointly developed to address employees with the inadequate basic skills necessary to operate modernized, technical equipment and maintain job security. Approximately 500 current employees of General Motors, Flint, Michigan, used…

  5. Planetary Atmosphere and Surfaces Chamber (PASC): A Platform to Address Various Challenges in Astrobiology

    NASA Astrophysics Data System (ADS)

    Mateo-Marti, Eva

    2014-08-01

    stability and presence of certain minerals on planetary surfaces and the potential habitability of microorganisms under various planetary environmental conditions can be studied using our apparatus. Therefore, these simulation chambers can address multiple different challenging and multidisciplinary astrobiological studies.

  6. Addressing Challenges to the Design & Test of Operational Lighting Environments for the International Space Station

    NASA Technical Reports Server (NTRS)

    Clark, Toni A.

    2014-01-01

    In our day to day lives, the availability of light, with which to see our environment, is often taken for granted. The designers of land based lighting systems use sunlight and artificial light as their toolset. The availability of power, quantity of light sources, and variety of design options are often unlimited. The accessibility of most land based lighting systems makes it easy for the architect and engineer to verify and validate their design ideas. Failures with an implementation, while sometimes costly, can easily be addressed by renovation. Consider now, an architectural facility orbiting in space, 260 miles above the surface of the earth. This human rated architectural facility, the International Space Station (ISS) must maintain operations every day, including life support and appropriate human comforts without fail. The facility must also handle logistics of regular shipments of cargo, including new passengers. The ISS requires accommodations necessary for human control of machine systems. Additionally, the ISS is a research facility and supports investigations performed inside and outside its livable volume. Finally, the facility must support remote operations and observations by ground controllers. All of these architectural needs require a functional, safe, and even an aesthetic lighting environment. At Johnson Space Center, our Habitability and Human Factors team assists our diverse customers with their lighting environment challenges, via physical test and computer based analysis. Because of the complexity of ISS operational environment, our team has learned and developed processes that help ISS operate safely. Because of the dynamic exterior lighting environment, uses computational modeling to predict the lighting environment. The ISS' orbit exposes it to a sunrise every 90 minutes, causing work surfaces to quickly change from direct sunlight to earthshine to total darkness. Proper planning of vehicle approaches, robotics operations, and crewed

  7. NAIMA as a solution for future GMO diagnostics challenges.

    PubMed

    Dobnik, David; Morisset, Dany; Gruden, Kristina

    2010-03-01

    In the field of genetically modified organism (GMO) diagnostics, real-time PCR has been the method of choice for target detection and quantification in most laboratories. Despite its numerous advantages, however, the lack of a true multiplexing option may render real-time PCR less practical in the face of future GMO detection challenges such as the multiplicity and increasing complexity of new transgenic events, as well as the repeated occurrence of unauthorized GMOs on the market. In this context, we recently reported the development of a novel multiplex quantitative DNA-based target amplification method, named NASBA implemented microarray analysis (NAIMA), which is suitable for sensitive, specific and quantitative detection of GMOs on a microarray. In this article, the performance of NAIMA is compared with that of real-time PCR, the focus being their performances in view of the upcoming challenge to detect/quantify an increasing number of possible GMOs at a sustainable cost and affordable staff effort. Finally, we present our conclusions concerning the applicability of NAIMA for future use in GMO diagnostics. PMID:19821160

  8. Polar Engineering and Research to Address Operational Challenges in Austere Environments

    NASA Astrophysics Data System (ADS)

    Mercer, J. L.; Richter-Menge, J.; Weale, J. C.; Lever, J. H.; Knuth, M. A.; Shoop, S. A.; Haehnel, R.; Arcone, S. A.; Bjella, K.; Finnegan, D. C.; Courville, Z.; Tracy, B. T.

    2009-12-01

    Logistics constraints and operational challenges in the austere environs of the polar regions present unique technological and engineering problems. Working closely with universities, government agencies and industry, the U.S. Army Corps of Engineers Cold Regions Research and Engineering Lab (CRREL) routinely conducts scientific research and engineering in the Arctic, sub-Arctic and Antarctic covering a wide range of topics and applications. Current areas of focus include: improved mobility techniques for overland traverses; robotic vehicles for traversing, sampling and data collection; snow road and transportation characterization; integrated operational systems including airfield consolidation proof-of-concept studies; infrastructure technology such as firn air cooling, building design, snow foundations and sewage handling; remote/renewable autonomous power solutions for data collection; subsurface radar for crevasse detection and cryosphere characterization; ground-based lidar topographic scanning and near-real-time climate/environmental monitoring linked to AIS infrastructure. While these research and engineering efforts provide solutions and improved technology for specific problems, the impacts are many and wide-reaching and the results are often applicable to other challenging environments. Here, an overview of current research foci and projects is presented along with in-the-field applications, effects and future implications. The results and solutions of these efforts typically lead to technological improvements in operations and logistics which are cost-beneficial, thus freeing up funding dollars for fundamental scientific research. The links between basic research and applied solutions delivering far-reaching impacts (both large- and small-scale) on society, the environment, industry and scientific research are also demonstrated.

  9. Ethical concepts and future challenges of neuroimaging: an Islamic perspective.

    PubMed

    Al-Delaimy, Wael K

    2012-09-01

    Neuroscience is advancing at a rapid pace, with new technologies and approaches that are creating ethical challenges not easily addressed by current ethical frameworks and guidelines. One fascinating technology is neuroimaging, especially functional Magnetic Resonance Imaging (fMRI). Although still in its infancy, fMRI is breaking new ground in neuroscience, potentially offering increased understanding of brain function. Different populations and faith traditions will likely have different reactions to these new technologies and the ethical challenges they bring with them. Muslims are approximately one-fifth of world population and they have a specific and highly regulated ethical and moral code, which helps them deal with scientific advances and decision making processes in an Islamically ethical manner. From this ethical perspective, in light of the relevant tenets of Islam, neuroimaging poses various challenges. The privacy of spirituality and the thought process, the requirement to put community interest before individual interest, and emphasis on conscious confession in legal situations are Islamic concepts that can pose a challenge for the use of something intrusive such as an fMRI. Muslim moral concepts such as There shall be no harm inflicted or reciprocated in Islam and Necessities overrule prohibitions are some of the criteria that might appropriately be used to guide advancing neuroscience. Neuroscientists should be particularly prudent and well prepared in implementing neuroscience advances that are breaking new scientific and ethical ground. Neuroscientists should also be prepared to assist in setting the ethical frameworks in place in advance of what might be perceived as runaway applications of technology. PMID:22865482

  10. Nanomaterials and future aerospace technologies: opportunities and challenges

    NASA Astrophysics Data System (ADS)

    Vaia, Richard A.

    2012-06-01

    Two decades of extensive investment in nanomaterials, nanofabrication and nanometrology have provided the global engineering community a vast array of new technologies. These technologies not only promise radical change to traditional industries, such as transportation, information and aerospace, but may create whole new industries, such as personalized medicine and personalized energy harvesting and storage. The challenge today for the defense aerospace community is determining how to accelerate the conversion of these technical opportunities into concrete benefits with quantifiable impact, in conjunction with identifying the most important outstanding scientific questions that are limiting their utilization. For example, nanomaterial fabrication delivers substantial tailorablity beyond a traditional material data sheet. How can we integrate this tailorability into agile manufacturing and design methods to further optimize the performance, cost and durability of future resilient aerospace systems? The intersection of nano-based metamaterials and nanostructured devices with biotechnology epitomizes the technological promise of autonomous systems and enhanced human-machine interfaces. What then are the key materials and processes challenges that are inhibiting current lab-scale innovation from being integrated into functioning systems to increase effectiveness and productivity of our human resources? Where innovation is global, accelerating the use of breakthroughs, both for commercial and defense, is essential. Exploitation of these opportunities and finding solutions to the associated challenges for defense aerospace will rely on highly effective partnerships between commercial development, scientific innovation, systems engineering, design and manufacturing.

  11. Wearable technologies – future challenges for implementation in healthcare services

    PubMed Central

    2015-01-01

    The growing use of wearable technologies increases the ability to have more information from the patient including clinical, behavioural and self-monitored data. The availability and large amounts of data that did not exist before brings an opportunity to develop new tools with intelligent analyses and decision support tools for use in clinical practice. It also opens new possibilities for the patients by providing them with more information and decision support tools specially designed for them, and empowers them in managing their own health conditions, keeping their autonomy. These new developments drive a change in healthcare delivery models and the relationship between patients and healthcare providers. It raises challenges for the healthcare systems in how to implement these new technologies and the growing amount of information in clinical practice, integrate it into the clinical workflows of the various healthcare providers. The future challenge for healthcare will be how to use the developing knowledge in a way that will bring added value to healthcare professionals, healthcare organisations and patients without increasing the workload and cost of the healthcare services. For wearable technology developers, the challenge is to develop solutions that can be easily integrated and used by healthcare professionals considering the existing constraints. PMID:26609396

  12. Infant nutrition and lifelong health: current perspectives and future challenges.

    PubMed

    Robinson, S M

    2015-10-01

    Understanding the role and importance of nutrition in early postnatal life, as an influence on lifelong vulnerability to poor health, is an important part of current research. We need to be able to define optimal patterns of infant feeding, not just to support growth and development in infancy, but also as determinants of later health. To date, much of the focus on the long-term effects of infant nutrition has been on milk feeding, to compare breast and formula feeding and to evaluate the effects of exclusivity, timing and duration of feeding different types of milk in infancy; other aspects of infant feeding such as age at introduction of solid foods and type of weaning diet have received less attention, and relatively little is known about their links to later health. Contemporary data are needed to enable us to move beyond explanation of historical infant feeding data in order to understand and predict health outcomes in future generations. Ongoing and new population studies, that include infants from diverse settings, will be key to providing generalizable data that can be used to define optimal feeding practice. There are some methodological challenges ahead, although significant progress has already been made, and further progress is envisaged in the future. In particular, the opportunity to bring together epidemiological studies and new mechanistic insights that will help identify key aspects of infant nutrition and their causal effects offer great promise both in moving this field forward as well as the potential for health benefits for future generations. PMID:26088394

  13. Impact, Challenges, and Future Projections of Vaccine Trials in Africa

    PubMed Central

    Idoko, Olubukola T.; Kochhar, Sonali; Agbenyega, Tsiri E.; Ogutu, Bernhards; Ota, Martin O. C.

    2013-01-01

    Immunization remains the most cost effective method for the control of infectious diseases. Therefore, there is a global effort to deploy new vaccines for disease control and eradication. These new vaccines must be tested in the settings in which they will be used. This necessity has required the conduct of many vaccine trials in Africa, where several infectious diseases with significant public health impact are prevalent. However, these areas have peculiarities and are just beginning to gain expertise in the conduct of such trials. The vaccine developers and sponsors of these trials may also not be conversant with some issues unique to the trial site. The understanding gap from both partners can result in challenges if not addressed during the planning phase of the trial. This review seeks to highlight the issues surrounding the conduct of clinical trials in resource-constrained settings and suggests some ways of circumventing them. PMID:23468356

  14. Challenges and future directions to evaluating the association between prenatal exposure to endocrine disrupting chemicals and childhood obesity

    PubMed Central

    Romano, Megan E.; Savitz, David A.; Braun, Joseph M.

    2014-01-01

    Obesity is an increasing public health threat worldwide. However, there has been insufficient research addressing the obesogenic potential of prenatal exposure to environmental endocrine disrupting chemicals, largely due to complexities in the design, analysis, and interpretation of such studies. This review describes relevant biological mechanisms, addresses current challenges for investigators, presents potential strategies for overcoming them, and identifies areas where further development is required to improve future research. Special considerations for exposure assessment, outcome heterogeneity, and complex confounding structures are described. PMID:25328860

  15. Biologically inspired robotic inspectors: the engineering reality and future outlook (Keynote address)

    NASA Astrophysics Data System (ADS)

    Bar-Cohen, Yoseph

    2005-04-01

    Human errors have long been recognized as a major factor in the reliability of nondestructive evaluation results. To minimize such errors, there is an increasing reliance on automatic inspection tools that allow faster and consistent tests. Crawlers and various manipulation devices are commonly used to perform variety of inspection procedures that include C-scan with contour following capability to rapidly inspect complex structures. The emergence of robots has been the result of the need to deal with parts that are too complex to handle by a simple automatic system. Economical factors are continuing to hamper the wide use of robotics for inspection applications however technology advances are increasingly changing this paradigm. Autonomous robots, which may look like human, can potentially address the need to inspect structures with configuration that are not predetermined. The operation of such robots that mimic biology may take place at harsh or hazardous environments that are too dangerous for human presence. Biomimetic technologies such as artificial intelligence, artificial muscles, artificial vision and numerous others are increasingly becoming common engineering tools. Inspired by science fiction, making biomimetic robots is increasingly becoming an engineering reality and in this paper the state-of-the-art will be reviewed and the outlook for the future will be discussed.

  16. Anaesthesia in underdeveloped world: Present scenario and future challenges.

    PubMed

    Bharati, Sachidanand Jee; Chowdhury, Tumul; Gupta, Nishkarsh; Schaller, Bernhard; Cappellani, Ronald B; Maguire, Doug

    2014-01-01

    The overall mortality and morbidity in underdeveloped countries are still unchanged and preventable risks factors constitute the main burden. Among these, anaesthesia-related mortality is largely preventable. Various contributory factors related to human resources, technical resources, education/teaching system and other utilities needs further attention in poor income group countries. Therefore, we have made an attempt to address all these issues in this educational article and have given special reference to those factors that might gain importance in (near) future. Proper understanding of anaesthesia-related resources, their overall impact on health care system and their improvisation methods should be thoroughly evaluated for providing safer anaesthesia care in these countries which would certainly direct better outcome and consequently influence mortality. PMID:24970961

  17. Academic Research Library as Broker in Addressing Interoperability Challenges for the Geosciences

    NASA Astrophysics Data System (ADS)

    Smith, P., II

    2015-12-01

    Data capture is an important process in the research lifecycle. Complete descriptive and representative information of the data or database is necessary during data collection whether in the field or in the research lab. The National Science Foundation's (NSF) Public Access Plan (2015) mandates the need for federally funded projects to make their research data more openly available. Developing, implementing, and integrating metadata workflows into to the research process of the data lifecycle facilitates improved data access while also addressing interoperability challenges for the geosciences such as data description and representation. Lack of metadata or data curation can contribute to (1) semantic, (2) ontology, and (3) data integration issues within and across disciplinary domains and projects. Some researchers of EarthCube funded projects have identified these issues as gaps. These gaps can contribute to interoperability data access, discovery, and integration issues between domain-specific and general data repositories. Academic Research Libraries have expertise in providing long-term discovery and access through the use of metadata standards and provision of access to research data, datasets, and publications via institutional repositories. Metadata crosswalks, open archival information systems (OAIS), trusted-repositories, data seal of approval, persistent URL, linking data, objects, resources, and publications in institutional repositories and digital content management systems are common components in the library discipline. These components contribute to a library perspective on data access and discovery that can benefit the geosciences. The USGS Community for Data Integration (CDI) has developed the Science Support Framework (SSF) for data management and integration within its community of practice for contribution to improved understanding of the Earth's physical and biological systems. The USGS CDI SSF can be used as a reference model to map to Earth

  18. An overview of current approaches and future challenges in physiological monitoring

    NASA Technical Reports Server (NTRS)

    Horst, Richard L.

    1988-01-01

    Sufficient evidence exists from laboratory studies to suggest that physiological measures can be useful as an adjunct to behavioral and subjective measures of human performance and capabilities. Thus it is reasonable to address the conceptual and engineering challenges that arise in applying this technology in operational settings. Issues reviewed include the advantages and disadvantages of constructs such as mental states, the need for physiological measures of performance, areas of application for physiological measures in operational settings, which measures appear to be most useful, problem areas that arise in the use of these measures in operational settings, and directions for future development.

  19. Imaging of intestinal fibrosis: current challenges and future methods

    PubMed Central

    Higgins, Peter DR

    2016-01-01

    Crohn’s disease (CD) activity assessments are dominated by inflammatory changes without discrete measurement of the coexisting fibrotic contribution to total bowel damage. Intestinal fibrosis impacts the development of severe structural complications and the overall natural history of CD. Measuring intestinal fibrosis is challenging and existing methods of disease assessment are unable to reliably distinguish fibrosis from inflammation. Both the immediate clinical need to measure fibrosis for therapeutic decision-making and the near-future need for tools to assess pipeline anti-fibrotic medications highlight the demand for biomarkers of fibrosis in CD. Developing non-invasive technologies exploit changes in intestinal perfusion, mechanical properties, and macromolecular content to provide quantitative markers of fibrosis. In this review of existing and experimental technologies for imaging intestinal fibrosis, we discuss the expanding capabilities of quantitative MR and ultrasound imaging, encouraging developments in non-invasive elastography, and emerging novel methods including photoacoustic imaging. PMID:27536361

  20. Trends and future challenges in sampling the deep terrestrial biosphere.

    PubMed

    Wilkins, Michael J; Daly, Rebecca A; Mouser, Paula J; Trexler, Ryan; Sharma, Shihka; Cole, David R; Wrighton, Kelly C; Biddle, Jennifer F; Denis, Elizabeth H; Fredrickson, Jim K; Kieft, Thomas L; Onstott, Tullis C; Peterson, Lee; Pfiffner, Susan M; Phelps, Tommy J; Schrenk, Matthew O

    2014-01-01

    Research in the deep terrestrial biosphere is driven by interest in novel biodiversity and metabolisms, biogeochemical cycling, and the impact of human activities on this ecosystem. As this interest continues to grow, it is important to ensure that when subsurface investigations are proposed, materials recovered from the subsurface are sampled and preserved in an appropriate manner to limit contamination and ensure preservation of accurate microbial, geochemical, and mineralogical signatures. On February 20th, 2014, a workshop on "Trends and Future Challenges in Sampling The Deep Subsurface" was coordinated in Columbus, Ohio by The Ohio State University and West Virginia University faculty, and sponsored by The Ohio State University and the Sloan Foundation's Deep Carbon Observatory. The workshop aims were to identify and develop best practices for the collection, preservation, and analysis of terrestrial deep rock samples. This document summarizes the information shared during this workshop. PMID:25309520

  1. Diagnosing fetal alcohol spectrum disorder: History, challenges and future directions

    PubMed Central

    Benz, Jennifer; Rasmussen, Carmen; Andrew, Gail

    2009-01-01

    Fetal alcohol spectrum disorder (FASD) is one of the most common preventable causes of developmental disability, and is currently one of the most pressing public health concerns in Canada. FASD refers to the range of physical, mental, behavioural and learning disabilities that an individual may acquire as a result of maternal alcohol consumption. In the present paper, the history of the diagnostic approach to alcohol-related disorders over the past 35 years is reviewed. Research supporting the importance of early diagnosis for the long-term outcomes and management of individuals with FASD is presented, and challenges that have plagued efforts to efficiently diagnose individuals with FASD are discussed. Finally, the study reviews the future directions and implications regarding current diagnostic strategies. PMID:20357921

  2. Musculoskeletal modelling in dogs: challenges and future perspectives.

    PubMed

    Dries, Billy; Jonkers, Ilse; Dingemanse, Walter; Vanwanseele, Benedicte; Vander Sloten, Jos; van Bree, Henri; Gielen, Ingrid

    2016-05-18

    Musculoskeletal models have proven to be a valuable tool in human orthopaedics research. Recently, veterinary research started taking an interest in the computer modelling approach to understand the forces acting upon the canine musculoskeletal system. While many of the methods employed in human musculoskeletal models can applied to canine musculoskeletal models, not all techniques are applicable. This review summarizes the important parameters necessary for modelling, as well as the techniques employed in human musculoskeletal models and the limitations in transferring techniques to canine modelling research. The major challenges in future canine modelling research are likely to centre around devising alternative techniques for obtaining maximal voluntary contractions, as well as finding scaling factors to adapt a generalized canine musculoskeletal model to represent specific breeds and subjects. PMID:27102147

  3. Identifying present challenges to reliable future transdermal drug delivery products.

    PubMed

    Giannos, Steven A

    2015-01-01

    Transdermal systems have become an accepted means of drug delivery, offering clinical benefits over other dosage forms. Although transdermal delivery has been very successful as a controlled release technology platform, there are a number of challenges that prevent this delivery route from achieving its fullest commercial potential. Additionally, beginning in 1997, transdermal drug delivery companies aligned with life science industries to deliver large molecules, peptides and proteins through the skin, which is difficult due to the skin barrier properties. A number of methods and technologies have been conceived to overcome the skin barrier. Among these are mechanical, chemical and thermal permeation enhancement techniques. These methods are briefly discussed as well as future directions for transdermal therapies. PMID:26419262

  4. Summary: present and future challenges for stem cell research.

    PubMed

    Hogan, B L M

    2008-01-01

    Stem cell research is being driven forward at an intense pace by creative interactions among scientists working in different fields. These include developmental and reproductive biology, regeneration, genomics, live cell imaging, RNA biology, and cancer biology, to name a few. Numerous model systems and techniques are being exploited, and lab scientists are teaming up with bioengineers and clinicians. The ferment of ideas that makes the field so exciting was in full evidence throughout the Symposium. However, many challenges still need to be overcome to translate basic discoveries into therapeutic outcomes that will save lives and fulfill the promises that have been made. This chapter summarizes some of the highlights of the Symposium and indicates future directions that are being taken by leaders in the field. PMID:19329577

  5. Imaging of intestinal fibrosis: current challenges and future methods.

    PubMed

    Stidham, Ryan W; Higgins, Peter Dr

    2016-08-01

    Crohn's disease (CD) activity assessments are dominated by inflammatory changes without discrete measurement of the coexisting fibrotic contribution to total bowel damage. Intestinal fibrosis impacts the development of severe structural complications and the overall natural history of CD. Measuring intestinal fibrosis is challenging and existing methods of disease assessment are unable to reliably distinguish fibrosis from inflammation. Both the immediate clinical need to measure fibrosis for therapeutic decision-making and the near-future need for tools to assess pipeline anti-fibrotic medications highlight the demand for biomarkers of fibrosis in CD. Developing non-invasive technologies exploit changes in intestinal perfusion, mechanical properties, and macromolecular content to provide quantitative markers of fibrosis. In this review of existing and experimental technologies for imaging intestinal fibrosis, we discuss the expanding capabilities of quantitative MR and ultrasound imaging, encouraging developments in non-invasive elastography, and emerging novel methods including photoacoustic imaging. PMID:27536361

  6. Origins, current status, and future challenges of green chemistry.

    PubMed

    Anastas, Paul T; Kirchhoff, Mary M

    2002-09-01

    Over the course of the past decade, green chemistry has demonstrated how fundamental scientific methodologies can protect human health and the environment in an economically beneficial manner. Significant progress is being made in several key research areas, such as catalysis, the design of safer chemicals and environmentally benign solvents, and the development of renewable feedstocks. Current and future chemists are being trained to design products and processes with an increased awareness for environmental impact. Outreach activities within the green chemistry community highlight the potential for chemistry to solve many of the global environmental challenges we now face. The origins and basis of green chemistry chart a course for achieving environmental and economic prosperity inherent in a sustainable world. PMID:12234198

  7. Trends and future challenges in sampling the deep terrestrial biosphere

    PubMed Central

    Wilkins, Michael J.; Daly, Rebecca A.; Mouser, Paula J.; Trexler, Ryan; Sharma, Shihka; Cole, David R.; Wrighton, Kelly C.; Biddle, Jennifer F.; Denis, Elizabeth H.; Fredrickson, Jim K.; Kieft, Thomas L.; Onstott, Tullis C.; Peterson, Lee; Pfiffner, Susan M.; Phelps, Tommy J.; Schrenk, Matthew O.

    2014-01-01

    Research in the deep terrestrial biosphere is driven by interest in novel biodiversity and metabolisms, biogeochemical cycling, and the impact of human activities on this ecosystem. As this interest continues to grow, it is important to ensure that when subsurface investigations are proposed, materials recovered from the subsurface are sampled and preserved in an appropriate manner to limit contamination and ensure preservation of accurate microbial, geochemical, and mineralogical signatures. On February 20th, 2014, a workshop on “Trends and Future Challenges in Sampling The Deep Subsurface” was coordinated in Columbus, Ohio by The Ohio State University and West Virginia University faculty, and sponsored by The Ohio State University and the Sloan Foundation’s Deep Carbon Observatory. The workshop aims were to identify and develop best practices for the collection, preservation, and analysis of terrestrial deep rock samples. This document summarizes the information shared during this workshop. PMID:25309520

  8. A review of smart homes- present state and future challenges.

    PubMed

    Chan, Marie; Estève, Daniel; Escriba, Christophe; Campo, Eric

    2008-07-01

    In the era of information technology, the elderly and disabled can be monitored with numerous intelligent devices. Sensors can be implanted into their home for continuous mobility assistance and non-obtrusive disease prevention. Modern sensor-embedded houses, or smart houses, cannot only assist people with reduced physical functions but help resolve the social isolation they face. They are capable of providing assistance without limiting or disturbing the resident's daily routine, giving him or her greater comfort, pleasure, and well-being. This article presents an international selection of leading smart home projects, as well as the associated technologies of wearable/implantable monitoring systems and assistive robotics. The latter are often designed as components of the larger smart home environment. The paper will conclude by discussing future challenges of the domain. PMID:18367286

  9. Reducing myocardial infarct size: challenges and future opportunities

    PubMed Central

    Bulluck, Heerajnarain; Yellon, Derek M; Hausenloy, Derek J

    2016-01-01

    Despite prompt reperfusion by primary percutaneous coronary intervention (PPCI), the mortality and morbidity of patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) remain significant with 9% death and 10% heart failure at 1 year. In these patients, one important neglected therapeutic target is ‘myocardial reperfusion injury’, a term given to the cardiomyocyte death and microvascular dysfunction which occurs on reperfusing ischaemic myocardium. A number of cardioprotective therapies (both mechanical and pharmacological), which are known to target myocardial reperfusion injury, have been shown to reduce myocardial infarct (MI) size in small proof-of-concept clinical studies—however, being able to demonstrate improved clinical outcomes has been elusive. In this article, we review the challenges facing clinical cardioprotection research, and highlight future therapies for reducing MI size and preventing heart failure in patients presenting with STEMI at risk of myocardial reperfusion injury. PMID:26674987

  10. Trends and Future Challenges in Sampling the Deep Terrestrial Biosphere

    SciTech Connect

    Wilkins, Michael J.; Daly, Rebecca; Mouser, Paula J.; Trexler, Ryan; Sharma, Shihka; Cole, David R.; Wrighton, Kelly C.; Biddle , Jennifer F.; Denis, Elizabeth; Fredrickson, Jim K.; Kieft, Thomas L.; Onstott, T. C.; Peterson, Lee; Pfiffner, Susan M.; Phelps, Tommy J.; Schrenk, Matthew O.

    2014-09-12

    Research in the deep terrestrial biosphere is driven by interest in novel biodiversity and metabolisms, biogeochemical cycling, and the impact of human activities on this ecosystem. As this interest continues to grow, it is important to ensure that when subsurface investigations are proposed, materials recovered from the subsurface are sampled and preserved in an appropriate manner to limit contamination and ensure preservation of accurate microbial, geochemical, and mineralogical signatures. On February 20th, 2014, a workshop on “Trends and Future Challenges in Sampling The Deep Subsurface” was coordinated in Columbus, Ohio by The Ohio State University and West Virginia University faculty, and sponsored by The Ohio State University and the Sloan Foundation’s Deep Carbon Observatory. The workshop aims were to identify and develop best practices for the collection, preservation, and analysis of terrestrial deep rock samples. This document summarizes the information shared during this workshop.

  11. Ultrasound-enhanced transdermal delivery: recent advances and future challenges

    PubMed Central

    Oberli, Matthias A; Schoellhammer, Carl M; Langer, Robert; Blankschtein, Daniel

    2016-01-01

    The skin is a formidable diffusion barrier that restricts passive diffusion to small (<500 Da) lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug delivery are maturing as an alternative to oral drug delivery and hypodermic injections. Ultrasound can reversibly and non-invasively permeabilize the diffusion barrier posed by the skin. This review discusses the mechanisms of ultrasound-permeability enhancement, and presents technological innovations in equipment miniaturization and recent advances in permeabilization capabilities. Additionally, potentially exciting applications, including protein delivery, vaccination, gene therapy and sensing of blood analytes, are discussed. Finally, the future challenges and opportunities associated with the use of ultrasound are discussed. It is stressed that developing ultrasound for suitable applications is key to ensure commercial success. PMID:25287389

  12. Addressing Challenges to Public Understanding of Science: Epistemic Cognition, Motivated Reasoning, and Conceptual Change

    ERIC Educational Resources Information Center

    Sinatra, Gale M.; Kienhues, Dorothe; Hofer, Barbara K.

    2014-01-01

    Science is of critical importance to daily life in a knowledge society and has a significant influence on many everyday decisions. As scientific problems increase in their number and complexity, so do the challenges facing the public in understanding these issues. Our objective is to focus on 3 of those challenges: the challenge of reasoning about…

  13. Nde Challenges with Future Commercial Aircraft-A Boeing Perspective

    NASA Astrophysics Data System (ADS)

    Kollgaard, J. R.; LaRiviere, S. G.

    2008-02-01

    Commercial aircraft have undergone revolutionary changes in design, configuration and materials. This produces new challenges to the NDE community ranging from process controls of raw materials, to testing and fabrication of structural components, to service damage assessments. As we drive NDE up the value stream, it will become imperative to understand variousprocess parameters and their relationship to product quality. NDE may play a key role in characterizing and controlling those parameters. In production, inspection has become a critical aspect in the processing of large, unitized structures. Penetrant, radiographic, and magnetic particle techniques are less applicable while ultrasonics has taken on a critical role, earlier in the build process. NDE data are acquired over large areas at rates far faster than before, creating challenges in the time required to analyze and document the data. Qualified inspectors, equipment, and techniques are essential. In the field, eddy current and shear wave ultrasonic methods, long a mainstay of aircraft maintenance, are beginning to yield to ultrasonic techniques involving C-scans and linear arrays. The building of new-generation airplanes has revealed shortcomings in existing NDE technology and in some cases enhanced the case for non-traditional methods. This paper will review Boeing's experience with NDE of advanced structures, in particular those present on the Boeing 787, and summarize the Boeing outlook for future NDE needs.

  14. [Influenza vaccination. Effectiveness of current vaccines and future challenges].

    PubMed

    Ortiz de Lejarazu, Raúl; Tamames, Sonia

    2015-01-01

    Seasonal influenza is an annual challenge for health-care systems, due to factors such as co-circulation of 2 influenza A subtypes jointly with 2 influenza B lineages; the antigenic drift of these virus, which eludes natural immunity, as well as immunity conferred by vaccination; together with influenza impact in terms of morbidity and mortality. Influenza vaccines have been available for more than 70 years and they have progressed in formulation, production and delivery route. Recommendations on vaccination are focused on those with a higher probability of severe disease, and have a progressively wider coverage, and classically based on inactivated vaccines, but with an increasing importance of attenuated live vaccines. More inactivated vaccines are becoming available, from adyuvanted and virosomal vaccines to intradermal delivery, cell-culture or quadrivalent. Overall vaccine effectiveness is about 65%, but varies depending on characteristics of vaccines, virus, population and the outcomes to be prevented, and ranges from less than 10% to almost 90%. Future challenges are formulations that confer more extensive and lasting protection, as well as increased vaccination coverage, especially in groups such as pregnant women and health-care professionals, as well as being extended to paediatrics. PMID:26232121

  15. Adjuvant chemotherapy for gastric cancer: Current evidence and future challenges

    PubMed Central

    Miceli, Rosalba; Tomasello, Gianluca; Bregni, Giacomo; Di Bartolomeo, Maria; Pietrantonio, Filippo

    2014-01-01

    Gastric cancer still represents one of the major causes of cancer mortality worldwide. Patients survival is mainly related to stage, with a high proportion of patients with metastatic disease at presentation. Thus, the cure rate largely depend upon surgical resection. Despite the additional, albeit small, benefit of adjuvant chemotherapy has been clearly demonstrated, no general consensus has been reached on the best treatment option. Moreover, the narrow therapeutic index of adjuvant chemotherapy (i.e., limited survival benefit with considerable toxicity) requires a careful assessment of expected risks and benefits for individual patients. Treatment choices vary widely based on the different geographic areas, with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United States. In the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and meta-analyses. The most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery; the same Authors also showed that disease-free survival may be used as a surrogate end-point for overall survival. We finally discuss future research issues such as the need of economic evaluations, development of prognostic or predictive biomarkers, and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment. PMID:24782604

  16. Future prospects for prophylactic immune stimulation in crustacean aquaculture - the need for improved metadata to address immune system complexity.

    PubMed

    Hauton, Chris; Hudspith, Meggie; Gunton, Laetitia

    2015-02-01

    Future expansion of the crustacean aquaculture industry will be required to ensure global food security. However, this expansion must ensure: (a) that natural resources (including habitat use and fish meal) are sustainably exploited, (b) that the socio-economic development of producing nations is safeguarded, and (c) that the challenge presented by crustacean diseases is adequately met. Conventionally, the problem of disease in crustacean aquaculture has been addressed through prophylactic administration of stimulants, additives or probiotics. However, these approaches have been questioned both experimentally and philosophically. In this review, we argue that real progress in the field of crustacean immune stimulants has now slowed, with only incremental advances now being made. We further contend that an overt focus on the immune effector response has been misguided. In light of the wealth of new data reporting immune system complexity, a more refined approach is necessary - one that must consider the important role played by pattern recognition proteins. In support of this more refined approach, there is now a much greater requirement for the reporting of essential metadata. We propose a broad series of recommendations regarding the 'Minimum Information required to support a Stimulant Assessment experiment' (MISA guidelines) to foster new progression within the field. PMID:24796867

  17. OpenTopography: Addressing Big Data Challenges Using Cloud Computing, HPC, and Data Analytics

    NASA Astrophysics Data System (ADS)

    Crosby, C. J.; Nandigam, V.; Phan, M.; Youn, C.; Baru, C.; Arrowsmith, R.

    2014-12-01

    OpenTopography (OT) is a geoinformatics-based data facility initiated in 2009 for democratizing access to high-resolution topographic data, derived products, and tools. Hosted at the San Diego Supercomputer Center (SDSC), OT utilizes cyberinfrastructure, including large-scale data management, high-performance computing, and service-oriented architectures to provide efficient Web based access to large, high-resolution topographic datasets. OT collocates data with processing tools to enable users to quickly access custom data and derived products for their application. OT's ongoing R&D efforts aim to solve emerging technical challenges associated with exponential growth in data, higher order data products, as well as user base. Optimization of data management strategies can be informed by a comprehensive set of OT user access metrics that allows us to better understand usage patterns with respect to the data. By analyzing the spatiotemporal access patterns within the datasets, we can map areas of the data archive that are highly active (hot) versus the ones that are rarely accessed (cold). This enables us to architect a tiered storage environment consisting of high performance disk storage (SSD) for the hot areas and less expensive slower disk for the cold ones, thereby optimizing price to performance. From a compute perspective, OT is looking at cloud based solutions such as the Microsoft Azure platform to handle sudden increases in load. An OT virtual machine image in Microsoft's VM Depot can be invoked and deployed quickly in response to increased system demand. OT has also integrated SDSC HPC systems like the Gordon supercomputer into our infrastructure tier to enable compute intensive workloads like parallel computation of hydrologic routing on high resolution topography. This capability also allows OT to scale to HPC resources during high loads to meet user demand and provide more efficient processing. With a growing user base and maturing scientific user

  18. Estimating the Health Effects of Greenhouse Gas Mitigation Strategies: Addressing Parametric, Model, and Valuation Challenges

    PubMed Central

    Hess, Jeremy J.; Ebi, Kristie L.; Markandya, Anil; Balbus, John M.; Wilkinson, Paul; Haines, Andy; Chalabi, Zaid

    2014-01-01

    simultaneously improving health. Citation: Remais JV, Hess JJ, Ebi KL, Markandya A, Balbus JM, Wilkinson P, Haines A, Chalabi Z. 2014. Estimating the health effects of greenhouse gas mitigation strategies: addressing parametric, model, and valuation challenges. Environ Health Perspect 122:447–455; http://dx.doi.org/10.1289/ehp.1306744 PMID:24583270

  19. Novel developments in benthic modelling to address scientific and policy challenges

    NASA Astrophysics Data System (ADS)

    Lessin, Gennadi; Artioli, Yuri; Bruggeman, Jorn; Aldridge, John; Blackford, Jerry

    2016-04-01

    Understanding the role of benthic systems in supporting, regulating and providing marine ecosystem services requires better understanding of their functioning and their response and resilience to stressors. Novel observational methods for the investigation of dynamics of benthic-pelagic coupling in shelf seas are being developed and new data is being collected. Therefore there is an increasing demand for robust representation of benthic processes in marine biogeochemical and ecosystem models, which would improve our understanding of whole systems and benthic-pelagic coupling, rather than act as mere closure terms for pelagic models. However, for several decades development of benthic models has lagged behind their pelagic counterparts. To address contemporary scientific, policy and societal challenges, the biogeochemical and ecological model ERSEM (European Regional Seas Ecosystem Model), including its benthic sub-model, was recently recoded in a scalable and modular format adopting the approach of FABM (Framework for Aquatic Biogeochemical Models). Within the Shelf Sea Biogeochemistry research programme, a series of additional processes have been included, such as a sedimentary carbonate system, a resuspendable fluff layer, and the simulation of advective sediments. It was shown that the inclusion of these processes changes the dynamics of benthic-pelagic fluxes as well as modifying the benthic food web. Comparison of model results with in-situ data demonstrated a general improvement of model performance and highlighted the importance of the benthic system in overall ecosystem dynamics. As an example, our simulations have shown that inclusion of a resuspendable fluff layer facilitates regeneration of inorganic nutrients in the water column due to degradation of resuspended organic material by pelagic bacteria. Moreover, the composition of fluff was found to be important for trophic interactions, and therefore indirectly affects benthic community composition. Where

  20. Treatment-resistant depression: therapeutic trends, challenges, and future directions

    PubMed Central

    Al-Harbi, Khalid Saad

    2012-01-01

    Background Patients with major depression respond to antidepressant treatment, but 10%–30% of them do not improve or show a partial response coupled with functional impairment, poor quality of life, suicide ideation and attempts, self-injurious behavior, and a high relapse rate. The aim of this paper is to review the therapeutic options for treating resistant major depressive disorder, as well as evaluating further therapeutic options. Methods In addition to Google Scholar and Quertle searches, a PubMed search using key words was conducted, and relevant articles published in English peer-reviewed journals (1990–2011) were retrieved. Only those papers that directly addressed treatment options for treatment-resistant depression were retained for extensive review. Results Treatment-resistant depression, a complex clinical problem caused by multiple risk factors, is targeted by integrated therapeutic strategies, which include optimization of medications, a combination of antidepressants, switching of antidepressants, and augmentation with non-antidepressants, psychosocial and cultural therapies, and somatic therapies including electroconvulsive therapy, repetitive transcranial magnetic stimulation, magnetic seizure therapy, deep brain stimulation, transcranial direct current stimulation, and vagus nerve stimulation. As a corollary, more than a third of patients with treatment-resistant depression tend to achieve remission and the rest continue to suffer from residual symptoms. The latter group of patients needs further study to identify the most effective therapeutic modalities. Newer biomarker-based antidepressants and other drugs, together with non-drug strategies, are on the horizon to address further the multiple complex issues of treatment-resistant depression. Conclusion Treatment-resistant depression continues to challenge mental health care providers, and further relevant research involving newer drugs is warranted to improve the quality of life of patients

  1. Addressing the Challenges of Multi-Domain Data Integration with the SemantEco Framework

    NASA Astrophysics Data System (ADS)

    Patton, E. W.; Seyed, P.; McGuinness, D. L.

    2013-12-01

    Data integration across multiple domains will continue to be a challenge with the proliferation of big data in the sciences. Data origination issues and how data are manipulated are critical to enable scientists to understand and consume disparate datasets as research becomes more multidisciplinary. We present the SemantEco framework as an exemplar for designing an integrative portal for data discovery, exploration, and interpretation that uses best practice W3C Recommendations. We use the Resource Description Framework (RDF) with extensible ontologies described in the Web Ontology Language (OWL) to provide graph-based data representation. Furthermore, SemantEco ingests data via the software package csv2rdf4lod, which generates data provenance using the W3C provenance recommendation (PROV). Our presentation will discuss benefits and challenges of semantic integration, their effect on runtime performance, and how the SemantEco framework assisted in identifying performance issues and improved query performance across multiple domains by an order of magnitude. SemantEco benefits from a semantic approach that provides an 'open world', which allows data to incrementally change just as it does in the real world. SemantEco modules may load new ontologies and data using the W3C's SPARQL Protocol and RDF Query Language via HTTP. Modules may also provide user interface elements for applications and query capabilities to support new use cases. Modules can associate with domains, which are first-class objects in SemantEco. This enables SemantEco to perform integration and reasoning both within and across domains on module-provided data. The SemantEco framework has been used to construct a web portal for environmental and ecological data. The portal includes water and air quality data from the U.S. Geological Survey (USGS) and Environmental Protection Agency (EPA) and species observation counts for birds and fish from the Avian Knowledge Network and the Santa Barbara Long Term

  2. Estimating and disclosing the risk of developing Alzheimer’s disease: challenges, controversies and future directions

    PubMed Central

    Roberts, J Scott; Tersegno, Sarah M

    2010-01-01

    With Alzheimer’s disease increasing in prevalence and public awareness, more people are becoming interested in learning their chances of developing this condition. Disclosing Alzheimer’s disease risk has been discouraged because of the limited predictive value of available tests, lack of prevention and treatment options, and concerns regarding potential psychological and social harms. However, challenges to this status quo include the availability of direct-to-consumer health risk information (e.g., genetic susceptibility tests), as well as a growing literature suggesting that people seeking risk information for Alzheimer’s disease through formal education and counseling protocols generally find it useful and do not experience adverse effects. This paper reviews current and potential methods of risk assessment for Alzheimer’s disease, discusses the process and impact of disclosing risk to interested patients and consumers, and considers the practical and ethical challenges in this emerging area. Anticipated future directions are addressed. PMID:20856693

  3. The GÉANT network: addressing current and future needs of the HEP community

    NASA Astrophysics Data System (ADS)

    Capone, Vincenzo; Usman, Mian

    2015-12-01

    The GÉANT infrastructure is the backbone that serves the scientific communities in Europe for their data movement needs and their access to international research and education networks. Using the extensive fibre footprint and infrastructure in Europe the GÉANT network delivers a portfolio of services aimed to best fit the specific needs of the users, including Authentication and Authorization Infrastructure, end-to-end performance monitoring, advanced network services (dynamic circuits, L2-L3VPN, MD-VPN). This talk will outline the factors that help the GÉANT network to respond to the needs of the High Energy Physics community, both in Europe and worldwide. The Pan-European network provides the connectivity between 40 European national research and education networks. In addition, GÉANT also connects the European NRENs to the R&E networks in other world region and has reach to over 110 NREN worldwide, making GÉANT the best connected Research and Education network, with its multiple intercontinental links to different continents e.g. North and South America, Africa and Asia-Pacific. The High Energy Physics computational needs have always had (and will keep having) a leading role among the scientific user groups of the GÉANT network: the LHCONE overlay network has been built, in collaboration with the other big world REN, specifically to address the peculiar needs of the LHC data movement. Recently, as a result of a series of coordinated efforts, the LHCONE network has been expanded to the Asia-Pacific area, and is going to include some of the main regional R&E network in the area. The LHC community is not the only one that is actively using a distributed computing model (hence the need for a high-performance network); new communities are arising, as BELLE II. GÉANT is deeply involved also with the BELLE II Experiment, to provide full support to their distributed computing model, along with a perfSONAR-based network monitoring system. GÉANT has also

  4. Strategies for Helping Parents of Young Children Address Challenging Behaviors in the Home

    ERIC Educational Resources Information Center

    Chai, Zhen; Lieberman-Betz, Rebecca

    2016-01-01

    Challenging behavior can be defined as any repeated pattern of behavior, or perception of behavior, that interferes with or is at risk of interfering with optimal learning or engagement in prosocial interactions with peers and adults. It is generally accepted in young children that challenging behaviors serve some sort of communicative purpose--to…

  5. Getting People Involved: The Benefit of Intellectual Capital Management for Addressing HR Challenges

    ERIC Educational Resources Information Center

    Pook, Katja

    2011-01-01

    Purpose: This paper aims to explore the benefits of intellectual capital assessment for facing current challenges of human resources work and organizational development. Design/methodology/approach: The paper takes findings of studies on challenges in HR work and maps them with features of intellectual capital assessment methods. It is thus a…

  6. Strategies to Address Challenging Behaviour in Young Children with Down Syndrome

    ERIC Educational Resources Information Center

    Feeley, Kathleen; Jones, Emily

    2008-01-01

    Children with Down syndrome are at an increased risk for engaging in challenging behaviour that may present problems within community, leisure, and educational settings, and, in many instances, precludes them from accessing these environments. Factors contributing to the occurrence of challenging behaviours include characteristics associated with…

  7. 75 FR 57006 - Addressing Policy and Logistical Challenges to Smart Grid Implementation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ...The Department of Energy (DOE) is seeking comments from interested parties on policy and logistical challenges that confront smart grid implementation, as well as recommendations on how to best overcome those challenges. DOE is undertaking this Request for Information (RFI) on behalf of the Administration and in consultation with key stakeholders from state regulatory bodies. The RFI will......

  8. Challenges to the Future Development of Iran's Protected Areas System

    NASA Astrophysics Data System (ADS)

    Kolahi, Mahdi; Sakai, Tetsuro; Moriya, Kazuyuki; Makhdoum, Majid F.

    2012-10-01

    Since the 1950s, there has been a continuous increase in the number and coverage of protected areas (PAs) in Iran, and in total 253 PAs have been declared that cover 10.12 % of the country's area. This paper reviews literature addressing Iran's PAs, examines what is known about them, highlights the challenges and lessons learned, and identifies areas where more research is needed. The PA system in Iran is criticized because of (1) shortages of manpower, equipment, and financial resources; (2) de jure PAs that are often implemented as de facto reserves; (3) lack of national biodiversity indicators and objective monitoring processes; and (4) limited public participation and conflict between people over PAs. To improve, Iran's PAs system needs to be realistically supported by policies and planning instruments. In addition, the implementation of active management to restore habitat, increase education and awareness, shift practices towards the guidelines of international organizations, build capacity, and improve management and co-management by local communities needs to occur.

  9. NASA Composite Materials Development: Lessons Learned and Future Challenges

    NASA Technical Reports Server (NTRS)

    Tenney, Darrel R.; Davis, John G., Jr.; Pipes, R. Byron; Johnston, Norman

    2009-01-01

    Composite materials have emerged as the materials of choice for increasing the performance and reducing the weight and cost of military, general aviation, and transport aircraft and space launch vehicles. Major advancements have been made in the ability to design, fabricate, and analyze large complex aerospace structures. The recent efforts by Boeing and Airbus to incorporate composite into primary load carrying structures of large commercial transports and to certify the airworthiness of these structures is evidence of the significant advancements made in understanding and use of these materials in real world aircraft. NASA has been engaged in research on composites since the late 1960 s and has worked to address many development issues with these materials in an effort to ensure safety, improve performance, and improve affordability of air travel for the public good. This research has ranged from synthesis of advanced resin chemistries to development of mathematical analyses tools to reliably predict the response of built-up structures under combined load conditions. The lessons learned from this research are highlighted with specific examples to illustrate the problems encountered and solutions to these problems. Examples include specific technologies related to environmental effects, processing science, fabrication technologies, nondestructive inspection, damage tolerance, micromechanics, structural mechanics, and residual life prediction. The current state of the technology is reviewed and key issues requiring additional research identified. Also, grand challenges to be solved for expanded use of composites in aero structures are identified.

  10. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research.

    PubMed

    Gillette-Guyonnet, Sophie; Secher, Marion; Vellas, Bruno

    2013-03-01

    The prevention of dementias, such as Alzheimer's disease (AD), is a growing public health concern, due to a lack of effective curative treatment options and a rising global prevalence. Various potential risk or preventive factors have been suggested by epidemiological research, including modifiable lifestyle factors such as diet. Current epidemiological data are in favour of a protective role of certain micronutrients (B vitamins related to homocysteine metabolism, the anti-oxidant vitamins C and E, flavonoids, polyunsatured omega-3 fatty acids, vitamin D) and macronutrients (fish) in the prevention of cognitive decline and dementia/AD. Some factors have been targeted by interventions tested in randomized controlled trials (RCTs), but many of the results are conflicting with observational evidence. Epidemiological analysis of the relations between nutrient consumption and cognitive decline is complex and it is highly unlikely that a single component plays a major role. In addition, since multiple factors across the life course influence brain function in late life, multidomain interventions might be more promising in the prevention of cognitive decline and dementia/AD. Designing such trials remains very challenging for researchers. The main objective of this paper is to review the epidemiologic data linking potential protective factors to cognitive decline or dementia/AD, focusing particularly on the roles of adiposity, caloric restriction, micro (group B vitamins related to homocysteine metabolism, the anti-oxidant vitamins C and E, flavonoids, polyunsatured omega-3 fatty acids, vitamin D) and macronutrients (fish). Limitations of the current data, divergence with results of interventional prevention studies and challenges for future research are discussed. PMID:23384081

  11. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research

    PubMed Central

    Gillette‐Guyonnet, Sophie; Secher, Marion; Vellas, Bruno

    2013-01-01

    The prevention of dementias, such as Alzheimer's disease (AD), is a growing public health concern, due to a lack of effective curative treatment options and a rising global prevalence. Various potential risk or preventive factors have been suggested by epidemiological research, including modifiable lifestyle factors such as diet. Current epidemiological data are in favour of a protective role of certain micronutrients (B vitamins related to homocysteine metabolism, the anti‐oxidant vitamins C and E, flavonoids, polyunsatured omega‐3 fatty acids, vitamin D) and macronutrients (fish) in the prevention of cognitive decline and dementia/AD. Some factors have been targeted by interventions tested in randomized controlled trials (RCTs), but many of the results are conflicting with observational evidence. Epidemiological analysis of the relations between nutrient consumption and cognitive decline is complex and it is highly unlikely that a single component plays a major role. In addition, since multiple factors across the life course influence brain function in late life, multidomain interventions might be more promising in the prevention of cognitive decline and dementia/AD. Designing such trials remains very challenging for researchers. The main objective of this paper is to review the epidemiologic data linking potential protective factors to cognitive decline or dementia/AD, focusing particularly on the roles of adiposity, caloric restriction, micro (group B vitamins related to homocysteine metabolism, the anti‐oxidant vitamins C and E, flavonoids, polyunsatured omega‐3 fatty acids, vitamin D) and macronutrients (fish). Limitations of the current data, divergence with results of interventional prevention studies and challenges for future research are discussed. PMID:23384081

  12. Bacterial genetics: past achievements, present state of the field, and future challenges.

    PubMed

    Schweizer, Herbert

    2008-04-01

    Genetic tools are required to take full advantage of the wealth of information generated by genome sequencing efforts and ensuing global gene and protein expression analyses. Bacterial genetics was originally developed and refined in Escherichia coli. As a consequence, elegant plasmid, cloning, expression, and mutagenesis systems were developed over the years and a good number of them are commercially available. This is not true for other bacteria. Although the development of genetic tools has generally not kept up with the sequencing pace, substantial progress has been made in this arena with many bacterial species. This short review highlights selected topics and achievements in the field over the past 25 years and presents some strategies that may help address future challenges. BioTechniques has played an integral part in the publication of important technological advances in the field over the first 25 years of its existence and it can be anticipated that it will continue to do so in the future. PMID:18474038

  13. Graphene as cancer theranostic tool: progress and future challenges.

    PubMed

    Orecchioni, Marco; Cabizza, Roberto; Bianco, Alberto; Delogu, Lucia Gemma

    2015-01-01

    Nowadays cancer remains one of the main causes of death in the world. Current diagnostic techniques need to be improved to provide earlier diagnosis and treatment. Traditional therapy approaches to cancer are limited by lack of specificity and systemic toxicity. In this scenario nanomaterials could be good allies to give more specific cancer treatment effectively reducing undesired side effects and giving at the same time accurate diagnosis and successful therapy. In this context, thanks to its unique physical and chemical properties, graphene, graphene oxide (GO) and reduced graphene (rGO) have recently attracted tremendous interest in biomedicine including cancer therapy. Herein we analyzed all studies presented in literature related to cancer fight using graphene and graphene-based conjugates. In this context, we aimed at the full picture of the state of the art providing new inputs for future strategies in the cancer theranostic by using of graphene. We found an impressive increasing interest in the material for cancer therapy and/or diagnosis. The majority of the works (73%) have been carried out on drug and gene delivery applications, following by photothermal therapy (32%), imaging (31%) and photodynamic therapy (10%). A 27% of the studies focused on theranostic applications. Part of the works here discussed contribute to the growth of the theranostic field covering the use of imaging (i.e. ultrasonography, positron electron tomography, and fluorescent imaging) combined to one or more therapeutic modalities. We found that the use of graphene in cancer theranostics is still in an early but rapidly growing stage of investigation. Any technology based on nanomaterials can significantly enhance their possibility to became the real revolution in medicine if combines diagnosis and therapy at the same time. We performed a comprehensive summary of the latest progress of graphene cancer fight and highlighted the future challenges and the innovative possible

  14. Graphene as Cancer Theranostic Tool: Progress and Future Challenges

    PubMed Central

    Orecchioni, Marco; Cabizza, Roberto; Bianco, Alberto; Delogu, Lucia Gemma

    2015-01-01

    Nowadays cancer remains one of the main causes of death in the world. Current diagnostic techniques need to be improved to provide earlier diagnosis and treatment. Traditional therapy approaches to cancer are limited by lack of specificity and systemic toxicity. In this scenario nanomaterials could be good allies to give more specific cancer treatment effectively reducing undesired side effects and giving at the same time accurate diagnosis and successful therapy. In this context, thanks to its unique physical and chemical properties, graphene, graphene oxide (GO) and reduced graphene (rGO) have recently attracted tremendous interest in biomedicine including cancer therapy. Herein we analyzed all studies presented in literature related to cancer fight using graphene and graphene-based conjugates. In this context, we aimed at the full picture of the state of the art providing new inputs for future strategies in the cancer theranostic by using of graphene. We found an impressive increasing interest in the material for cancer therapy and/or diagnosis. The majority of the works (73%) have been carried out on drug and gene delivery applications, following by photothermal therapy (32%), imaging (31%) and photodynamic therapy (10%). A 27% of the studies focused on theranostic applications. Part of the works here discussed contribute to the growth of the theranostic field covering the use of imaging (i.e. ultrasonography, positron electron tomography, and fluorescent imaging) combined to one or more therapeutic modalities. We found that the use of graphene in cancer theranostics is still in an early but rapidly growing stage of investigation. Any technology based on nanomaterials can significantly enhance their possibility to became the real revolution in medicine if combines diagnosis and therapy at the same time. We performed a comprehensive summary of the latest progress of graphene cancer fight and highlighted the future challenges and the innovative possible

  15. [Eating disorders: state of the art research and future challenges].

    PubMed

    Voderholzer, U; Cuntz, U; Schlegl, S

    2012-11-01

    Eating disorders are a common mental disorder during adolescence and young adulthood. While prevalence rates of eating disorders dramatically increased during the second half of the last century, these rates have remained relatively stable over the last 20 years. According to ICD-10 eating disorders are diagnostically categorized as anorexia nervosa, bulimia nervosa and atypical eating disorders or eating disorders not otherwise specified. Concerning the etiology, genetic factors are involved, especially in anorexia nervosa, as well as psychological and sociocultural factors. Evidence-based recommendations are available for the treatment of bulimia nervosa and binge eating disorder and in this context cognitive behavioral therapy is seen as the first choice. In contrast, the state of knowledge concerning the treatment of anorexia nervosa is still limited, especially concerning effective treatments for adults. Recent data only provide evidence for the effectiveness of family therapy for adolescents. Due to the lack of high quality studies, research on therapy for anorexia nervosa is a future challenge. PMID:23104604

  16. Urban design and health: progress to date and future challenges.

    PubMed

    Lowe, Melanie; Boulange, Claire; Giles-Corti, Billie

    2014-04-01

    Over the last 15 years, a growing body of Australian and international evidence has demonstrated that urban design attributes are associated with a range of health outcomes. For example, the location of employment, shops and services, provision of public and active transport infrastructure and access to open space and recreational opportunities are associated with chronic disease risk factors such as physical activity levels, access to healthy food, social connectedness, and air quality. Despite the growing knowledge base, this evidence is not being consistently translated into urban planning policy and practice in Australia. Low-density neighbourhoods with poor access to public transport, shops and services continue to be developed at a rapid rate in the sprawling outer suburbs of Australian cities. This paper provides an overview of the evidence of the association between the built environment and chronic diseases, highlighting progress and future challenges for health promotion. It argues that health promotion practitioners and researchers need to more closely engage with urban planning practitioners, policymakers and researchers to encourage the creation of healthy urban environments through integrated transport, land use and infrastructure planning. There is also a need for innovative research to evaluate the effectiveness of policy options. This would help evidence to be more effectively translated into policy and practice, making Australia a leader in planning healthy communities. PMID:24739774

  17. Future challenges for the treatment of liver tumors.

    PubMed

    Di Carlo, Isidoro; Toro, Adriana

    2013-04-01

    The annual World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO) was held in Bangkok, Thailand, from 5-9 December 2012, hosted under the auspices of the President of the Association, Masatoshi Makuuchi and the General Secretary Nicolas Lygidakis. The President of the Congress and of the local committee was Nopadol Wora-Urai from Bangkok University (Bangkok, Thailand). The organization of the congress was excellent, and both the location and the kindness of the local people were marvellous. The congress was supported by 665 participants from 62 countries, including speakers from Europe, America, Africa, Asia and Australia. The program included symposia, videos, free papers and poster sessions. The scientific sessions also provided live surgery and lunch lectures. The congress offered the opportunity to exchange knowledge about the challenges and controversies involved in the management of abdominal diseases. This paper analyzes current possibilities and future expectations for the diagnosis and treatment of liver tumors, especially hepatocellular carcinomas and liver metastases from colorectal cancer. PMID:23560371

  18. Idiopathic intracranial hypertension: ongoing clinical challenges and future prospects

    PubMed Central

    Julayanont, Parunyou; Karukote, Amputch; Ruthirago, Doungporn; Panikkath, Deepa; Panikkath, Ragesh

    2016-01-01

    Idiopathic intracranial hypertension (IIH) is an uncommon disorder characterized by increased intracranial pressure without radiological or laboratory evidence of intracranial pathology except empty sella turcica, optic nerve sheath with filled out cerebrospinal fluid spaces, and smooth-walled nonflow-related venous sinus stenosis or collapse. This condition typically affects obese women. The incidence of IIH is increasing with the rising prevalence of obesity. Persistent headache is the most common symptom. Visual impairment is a serious complication that may not be recognized by the patients. This paper reviews clinical manifestations, diagnostic challenges, and current treatments of IIH in adults. Various imaging modalities have been studied on their validity for detection of IIH and papilledema. This review also includes new studies on medical, surgical, and interventional management of this condition. Acetazolamide and topiramate are the only two medications that have been studied in randomized controlled trials about their efficacy in treatment of IIH. In patients who have severe visual impairment or progressive visual deterioration despite medical management, surgical or interventional treatment may be considered. The efficacy and complications of cerebrospinal fluid diversion, optic nerve sheath fenestration, and endovascular venous stenting reported in the last 3 decades have been summarized in this review. Finally, the prospective aspects of biomarkers and treatments are proposed for future research. PMID:26929666

  19. Idiopathic intracranial hypertension: ongoing clinical challenges and future prospects.

    PubMed

    Julayanont, Parunyou; Karukote, Amputch; Ruthirago, Doungporn; Panikkath, Deepa; Panikkath, Ragesh

    2016-01-01

    Idiopathic intracranial hypertension (IIH) is an uncommon disorder characterized by increased intracranial pressure without radiological or laboratory evidence of intracranial pathology except empty sella turcica, optic nerve sheath with filled out cerebrospinal fluid spaces, and smooth-walled nonflow-related venous sinus stenosis or collapse. This condition typically affects obese women. The incidence of IIH is increasing with the rising prevalence of obesity. Persistent headache is the most common symptom. Visual impairment is a serious complication that may not be recognized by the patients. This paper reviews clinical manifestations, diagnostic challenges, and current treatments of IIH in adults. Various imaging modalities have been studied on their validity for detection of IIH and papilledema. This review also includes new studies on medical, surgical, and interventional management of this condition. Acetazolamide and topiramate are the only two medications that have been studied in randomized controlled trials about their efficacy in treatment of IIH. In patients who have severe visual impairment or progressive visual deterioration despite medical management, surgical or interventional treatment may be considered. The efficacy and complications of cerebrospinal fluid diversion, optic nerve sheath fenestration, and endovascular venous stenting reported in the last 3 decades have been summarized in this review. Finally, the prospective aspects of biomarkers and treatments are proposed for future research. PMID:26929666

  20. Application and future challenges of functional nanocarbon hybrids.

    PubMed

    Shearer, Cameron J; Cherevan, Alexey; Eder, Dominik

    2014-04-16

    Hybridizing nanocarbons, such as carbon nanotubes (CNTs) or graphene, with an active material is a powerful strategy towards designing next-generation functional materials for environmental and sustainable energy applications. While research on nanocomposites, created by dispersing the nanocarbon into polymer or ceramic matrices, began almost immediately after the popularization of CNTs and graphene in 1991 and 2004, respectively, nanocarbon hybrids are a relatively recent addition to the family of composite materials. In contrast to nanocomposites, which typically combine the intrinsic properties of both compounds, nanocarbon hybrids additionally provide access to both a large surface area required for gas/liquid-solid interactions and an extended interface, through which charge and energy transfer processes create synergistic effects that result in unique properties and superior performance. This progress report looks at the history of research on nanocarbons (fullerenes, CNTs and graphene) and their composites and hybrids, presents the origin of synergistic effects, reviews the most intriguing results on nanocarbon hybrid performance in heterogeneous catalysis, electrocatalysis, photocatalysis, batteries, supercapacitors, photovoltaics and sensors, and discusses remaining challenges and future research directions. PMID:24677386

  1. Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy

    PubMed Central

    Nau, Gerard J.; Ross, Ted M.; Evans, Thomas G.; Chakraborty, Krishnendu; Empey, Kerry M.; Flynn, JoAnne L.

    2014-01-01

    Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The “Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy” session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials. PMID:25148426

  2. Cybersuicide and the adolescent population: challenges of the future?

    PubMed

    Birbal, Ria; Maharajh, Hari D; Birbal, Risa; Clapperton, Maria; Jarvis, Johnathan; Ragoonath, Anushka; Uppalapati, Kali

    2009-01-01

    Cybersuicide is a term used in reference to suicide and its ideations on the Internet. Cybersuicide is associated with websites that lure vulnerable members of society and empower them with various methods and approaches to deliberate self-harm. Ease of accessibility to the Internet and the rate at which information is dispersed contribute to the promotion of 'offing' one's self which is particularly appealing to adolescents. This study aims to explore this phenomenon, which seems to be spreading across generations, cultures, and races. Information and articles regarding Internet suicide and other terminology, as well as sub-classifications concerning this new form of suicide, were reviewed. Through search engines such as Google, Yahoo and Wikipedia, we investigated the differentiations between 'web cam' suicide, 'net suicide packs', sites that merely offer advice on how to commit suicide and sites that are essential in providing the means of performing the act. Additionally, materials published in scientific journals and data published by the Public Health Services, Centers for Disease Control, and materials from private media agencies were reviewed. Resources were also sourced from The Faculty of Medical Sciences Library, UWI at Mt. Hope. Cybersuicide is a worldwide problem among adolescents and a challenge of the future. PMID:19702194

  3. Challenges and future in vaccines, drug development, and immunomodulatory therapy.

    PubMed

    Kling, Heather M; Nau, Gerard J; Ross, Ted M; Evans, Thomas G; Chakraborty, Krishnendu; Empey, Kerry M; Flynn, JoAnne L

    2014-08-01

    Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The "Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy" session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials. PMID:25148426

  4. Pathology of pancreatic ductal adenocarcinoma: facts, challenges and future developments.

    PubMed

    Esposito, Irene; Konukiewitz, Björn; Schlitter, Anna Melissa; Klöppel, Günter

    2014-10-14

    Despite major improvements concerning its diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology, as interface discipline between basic and clinical medicine, has substantially contributed to the recent developments and has laid the basis for further progress. The definition and classification of precursor lesions of PDAC and their molecular characterization is a fundamental step for the potential identification of biomarkers and the development of imaging methods for early detection. In addition, by integrating findings in humans with the knowledge acquired through the investigation of transgenic mouse models for PDAC, a new model for pancreatic carcinogenesis has been proposed and partially validated in individuals with genetic predisposition for PDAC. The introduction and validation of a standardized system for pathology reporting based on the axial slicing technique has shown that most pancreatic cancer resections are R1 resections and that this is due to inherent anatomical and biological properties of PDAC. This standardized assessment of prognostic relevant parameters represents the basis for the successful conduction of multicentric studies and for the interpretation of their results. Finally, recent studies have shown that distinct molecular subtypes of PDAC exist and are associated with different prognosis and therapy response. The prospective validation of these results and the integration of molecular analyses in a comprehensive pathology report in the context of individualised cancer therapy represent a major challenge for the future. PMID:25320520

  5. The acute hepatic porphyrias: current status and future challenges.

    PubMed

    Siegesmund, Marko; van Tuyll van Serooskerken, Anne-Moniek; Poblete-Gutiérrez, Pamela; Frank, Jorge

    2010-10-01

    The porphyrias are predominantly inherited metabolic disorders, which result from a specific deficiency of one of the eight enzymes along the pathway of haem biosynthesis. Historically, they have been classified into hepatic and erythropoietic forms, based on the primary site of expression of the prevailing dysfunctional enzyme. From a clinical point of view, however, it is more convenient to subdivide them into acute and non-acute porphyrias, thereby primarily considering the potential occurrence of life-threatening acute neurovisceral attacks. Unrecognised or untreated, such an acute porphyric attack is associated with a significant mortality of up to 10%. The acute hepatic porphyrias comprise acute intermittent porphyria, variegate porphyria, hereditary coproporphyria, and δ-aminolevulinic acid dehydratase deficiency porphyria. Making a precise diagnosis may be difficult because the different types of porphyrias may show overlapping clinical and biochemical characteristics. To date, the therapeutic possibilities are limited and mainly symptomatic. In this overview we report on what is currently known about pathogenesis, clinic, diagnostics, and therapy of the acute hepatic porphyrias. We further point out actual and future challenges in the management of these diseases. PMID:20955962

  6. A longitudinal study of the health status of a community of religious sisters: addressing the advantages, challenges, and limitations.

    PubMed

    Gaspar, Phyllis Meyer; Bautch, Judith C; Strodthoff, Caritas M

    2015-01-01

    Longitudinal studies are recognized as contributing to understanding the complexity of aging and generating insights that cannot be gained using other research methods. However, conducting longitudinal studies is recognized as challenging, especially among older adults. The purpose of the current review is to describe how the authors addressed the limitations and challenges of longitudinal studies in a study of the health status of a community of religious sisters. Methods of this specific longitudinal study are presented to provide background to the discussion. Challenges, limitations, and advantages of the current longitudinal study are organized into three categories (i.e., sample, method, and data analysis) that have been addressed in the literature as contributing to the fidelity of longitudinal studies. The unique characteristics of the current study sample, particularly their access to health care, creates a comparison group for the study of older women in general. PMID:25860013

  7. America's Water Supply Challenge: Adaptation to Future Population Growth and Climate Change

    NASA Astrophysics Data System (ADS)

    Mahat, V.; Brown, T. C.; Ramirez, J. A.

    2014-12-01

    Water shortages, and the prospect of such shortages, have been repeatedly faced and addressed as population and economic growth placed increasing demands on available water over the past century. Such challenges have been most common in arid areas, but also have been encountered in some more humid portions of the US during times of drought. The challenges have been met using a wide range of adaptation measures, from large infrastructure projects (e.g., major trans-basin diversions) to alterations in local water prices (e.g., increasing block pricing). The future may bring even greater adaptation challenges as, in addition to continued growth in population, climate change will reduce water supplies in many locations. In this study we report on the relative importance of changes in demand versus changes in supply in causing projected future shortages in basins throughout the contiguous U.S. under different sets of socioeconomic and climatic conditions. We then examine the degree to which projected shortages can be avoided through adaptation. The adaptations examined include reductions in demand of major water use sectors, alterations in water management infrastructure, and inter-basin water transfers.

  8. Past, Current, and Future Challenges in Linking Data to Publications

    NASA Astrophysics Data System (ADS)

    Hanson, B.

    2015-12-01

    Data are the currency of science and assure the integrity of published research. As the ability to collect, analyze, and visualize data has grown beyond what could be included in a publication, and as the value of the data become more clear (or the lack of availability of data was criticized), publishers and the scientific community developed several solutions to enhance access to underlying data. Most leading journals now require authors to agree as a condition of submission that underlying data will be included or made available; indeed, publication is the key leverage point in exposing much scholarly data. Most journals allow PDF or other supplements and links to data sets hosted by authors or labs, or better, data repositories such as Dryad, and some have banned "data not shown" or any reference to unpublished work. Many of these solutions have proven problematic and recent studies have found that large fraction of data are undiscoverable even a few years after publication. The best solution has been dedicated domain repositories collectively supported by publishers, funders, and the scientific community and where deposition is required before or at the time of publication. These provide quality control and curation and facilitate reuse. However, expanding these beyond a few key repositories and developing standardized workflows and functionality among repositories and between them and publishers has been problematic. Addressing these and other data challenges requires collaborative efforts among funders, publishers, repositories, societies, and researchers. One example is the Coalition on Publishing Data in the the Earth and space sciences, where most major publishers and repositories have signed a joint statement of commitment (COPDESS.org), and are starting work to direct and link published data to domain repositories. Much work remains to be done. Major challenges include establishing data curation practices into the workflow of science from data collection

  9. Bioenergy crop models: Descriptions, data requirements and future challenges

    SciTech Connect

    Surendran Nair, Sujith; Kang, Shujiang; Zhang, Xuesong; Miguez, Fernando; Izaurralde, Roberto C.; Post, W. M.; Dietze, Michael; Lynd, Lee R.; Wullschleger, Stan D.

    2012-03-15

    Field studies that address the production of lignocellulosic biomass as a potential source of renewable energy are making available critical information for the development, validation, and use of bioenergy crop models. A literature survey revealed that 14 models have been developed and validated for herbaceous and woody bioenergy crops, and for Crassulacean acid metabolism (CAM) crops adapted to arid lands. These models simulate field-scale production of biomass for switchgrass (ALMANAC, EPIC, and Agro-BGC), miscanthus (MISCANFOR, MISCANMOD, and WIMOVAC), sugarcane (APSIM, AUSCANE, and CANEGRO), and poplar and willow (SECRETS and 3PG). Two models are adaptations of dynamic global vegetation models and simulate biomass yields of miscanthus and sugarcane as plant function types at regional scales (Agro-IBIS and LPJmL). A model of biomass production in CAM plants has been developed (EPI), but lacks the sophistication of the other models. Except for CAM plants, all the models include representations of leaf area dynamics, radiation interception and utilization, biomass production, and partitioning of biomass to roots and shoots. A few of the models are capable of simulating soil water, nutrient, and carbon cycle processes, making them especially useful for assessing environmental consequences (e.g., erosion and nutrient losses) associated with the field-scale deployment of bioenergy crops. Similar to other process-based models, simulations are challenged by computing and data management issues and an integrated framework for model testing and inter-comparison is needed. Considerable work remains concerning the development of models for unconventional bioenergy crops like CAM plants, generation and distribution of high-quality field data for model development and validation, and development of an integrated framework for efficient execution of large-scale simulations for use in planning regional to global sustainable bioenergy production systems.

  10. Software-Based Challenges of Developing the Future Distribution Grid

    SciTech Connect

    Stewart, Emma; Kiliccote, Sila; McParland, Charles

    2014-06-01

    The software that the utility industry currently uses may be insufficient to analyze the distribution grid as it rapidly modernizes to include active resources such as distributed generation, switch and voltage control, automation, and increasingly complex loads. Although planners and operators have traditionally viewed the distribution grid as a passive load, utilities and consultants increasingly need enhanced analysis that incorporates active distribution grid loads in order to ensure grid reliability. Numerous commercial and open-source tools are available for analyzing distribution grid systems. These tools vary in complexity from providing basic load-flow and capacity analysis under steady-state conditions to time-series analysis and even geographical representations of dynamic and transient events. The need for each type of analysis is not well understood in the industry, nor are the reasons that distribution analysis requires different techniques and tools both from those now available and from those used for transmission analysis. In addition, there is limited understanding of basic capability of the tools and how they should be practically applied to the evolving distribution system. The study reviews the features and state of the art capability of current tools, including usability and visualization, basic analysis functionality, advanced analysis including inverters, and renewable generation and load modeling. We also discuss the need for each type of distribution grid system analysis. In addition to reviewing basic functionality current models, we discuss dynamics and transient simulation in detail and draw conclusions about existing software?s ability to address the needs of the future distribution grid as well as the barriers to modernization of the distribution grid that are posed by the current state of software and model development. Among our conclusions are that accuracy, data transfer, and data processing abilities are key to future

  11. The role and challenges of the food industry in addressing chronic disease

    PubMed Central

    2010-01-01

    Summary Increasingly, food companies play an important role in stemming the rising burden of nutrition-related chronic diseases. Concrete actions taken by these companies include global public commitments to address food reformulation, consumer information, responsible marketing, promotion of healthy lifestyles, and public-private partnerships. These actions are reviewed together with eleven specific PepsiCo goals and commitments that address products, the marketplace, and communities at large. Interim progress on these goals and commitments are discussed as well as constraints hampering faster progress. Further disease prevention depends on increasing implementation of private-public initiatives. PMID:20509876

  12. Digital multicolor printing: state of the art and future challenges

    NASA Astrophysics Data System (ADS)

    Kipphan, Helmut

    1995-04-01

    a very high level in technology, productivity and quality, but that there is still space for improvements and innovations. Manufacturers of equipment and producers of printed products can take part in a successful evolution-changes, chances and challenges must be recognized and considered for future orientated activities and investments.

  13. Multiscale Modeling in Computational Biomechanics: Determining Computational Priorities and Addressing Current Challenges

    SciTech Connect

    Tawhai, Merryn; Bischoff, Jeff; Einstein, Daniel R.; Erdemir, Ahmet; Guess, Trent; Reinbolt, Jeff

    2009-05-01

    Abstract In this article, we describe some current multiscale modeling issues in computational biomechanics from the perspective of the musculoskeletal and respiratory systems and mechanotransduction. First, we outline the necessity of multiscale simulations in these biological systems. Then we summarize challenges inherent to multiscale biomechanics modeling, regardless of the subdiscipline, followed by computational challenges that are system-specific. We discuss some of the current tools that have been utilized to aid research in multiscale mechanics simulations, and the priorities to further the field of multiscale biomechanics computation.

  14. Addressing Challenges in Studies of Behavioral Responses of Whales to Noise.

    PubMed

    Cato, Douglas H; Dunlop, Rebecca A; Noad, Michael J; McCauley, Robert D; Kniest, Eric; Paton, David; Kavanagh, Ailbhe S

    2016-01-01

    Studying the behavioral response of whales to noise presents numerous challenges. In addition to the characteristics of the noise exposure, many factors may affect the response and these must be measured and accounted for in the analysis. An adequate sample size that includes matching controls is crucial if meaningful results are to be obtained. Field work is thus complicated, logistically difficult, and expensive. This paper discusses some of the challenges and how they are being met in a large-scale multiplatform project in which humpback whales are exposed to the noise of seismic air guns. PMID:26610954

  15. A Problem-Solving Approach to Addressing Current Global Challenges in Education

    ERIC Educational Resources Information Center

    Chapman, Judith D.; Aspin, David N.

    2013-01-01

    This paper begins with an analysis of global problems shaping education, particularly as they impact upon learning and life chances. In addressing these problems a range of philosophical positions and controversies are considered, including: traditional romantic and institutional views of schooling; and more recent maximalist, neo-liberal,…

  16. Facilitators, Challenges, and Collaborative Activities in Faith and Health Partnerships to Address Health Disparities

    ERIC Educational Resources Information Center

    Kegler, Michelle C.; Hall, Sarah M.; Kiser, Mimi

    2010-01-01

    Interest in partnering with faith-based organizations (FBOs) to address health disparities has grown in recent years. Yet relatively little is known about these types of partnerships. As part of an evaluation of the Institute for Faith and Public Health Collaborations, representatives of 34 faith--health teams (n = 61) completed semi-structured…

  17. Addressing Wife Abuse in Mexican Immigrant Couples: Challenges for Family Social Workers

    ERIC Educational Resources Information Center

    Hancock, Tina

    2006-01-01

    This article addresses wife abuse in undocumented Mexican immigrant couples and suggests an ecosystems treatment approach that takes into consideration the structural forces of oppression and discrimination on abusive behaviors in the home and combines individual, family and community level interventions to help immigrant men stop the abuse.…

  18. Addressing Evaluation Challenges of Grassroots Family Support Programs: The MIHOW Program.

    ERIC Educational Resources Information Center

    Maloney, Erin; Davis, Kenneth

    This paper describes the process used by the Maternal Infant Health Outreach Worker Program (MIHOW), a program of the Center for Health Services at Vanderbilt University, to develop its program evaluation with limited evaluation resources. The evaluation addresses the empowerment of grassroots participants in two projects: the MIHOW Pre- and…

  19. Crop immunity against viruses: outcomes and future challenges

    PubMed Central

    Nicaise, Valérie

    2014-01-01

    Viruses cause epidemics on all major cultures of agronomic importance, representing a serious threat to global food security. As strict intracellular pathogens, they cannot be controlled chemically and prophylactic measures consist mainly in the destruction of infected plants and excessive pesticide applications to limit the population of vector organisms. A powerful alternative frequently employed in agriculture relies on the use of crop genetic resistances, approach that depends on mechanisms governing plant–virus interactions. Hence, knowledge related to the molecular bases of viral infections and crop resistances is key to face viral attacks in fields. Over the past 80 years, great advances have been made on our understanding of plant immunity against viruses. Although most of the known natural resistance genes have long been dominant R genes (encoding NBS-LRR proteins), a vast number of crop recessive resistance genes were cloned in the last decade, emphasizing another evolutive strategy to block viruses. In addition, the discovery of RNA interference pathways highlighted a very efficient antiviral system targeting the infectious agent at the nucleic acid level. Insidiously, plant viruses evolve and often acquire the ability to overcome the resistances employed by breeders. The development of efficient and durable resistances able to withstand the extreme genetic plasticity of viruses therefore represents a major challenge for the coming years. This review aims at describing some of the most devastating diseases caused by viruses on crops and summarizes current knowledge about plant–virus interactions, focusing on resistance mechanisms that prevent or limit viral infection in plants. In addition, I will discuss the current outcomes of the actions employed to control viral diseases in fields and the future investigations that need to be undertaken to develop sustainable broad-spectrum crop resistances against viruses. PMID:25484888

  20. Using a Sampling Strategy to Address Psychometric Challenges in Tutorial-Based Assessments

    ERIC Educational Resources Information Center

    Eva, Kevin W.; Solomon, Patty; Neville, Alan J.; Ladouceur, Michael; Kaufman, Karyn; Walsh, Allyn; Norman, Geoffrey R.

    2007-01-01

    Introduction: Tutorial-based assessment, despite providing a good match with the philosophy adopted by educational programmes that emphasize small group learning, remains one of the greatest challenges for educators working in this context. The current study was performed in an attempt to assess the psychometric characteristics of tutorial-based…

  1. A Model Driven Framework to Address Challenges in a Mobile Learning Environment

    ERIC Educational Resources Information Center

    Khaddage, Ferial; Christensen, Rhonda; Lai, Wing; Knezek, Gerald; Norris, Cathie; Soloway, Elliot

    2015-01-01

    In this paper a review of the pedagogical, technological, policy and research challenges and concepts underlying mobile learning is presented, followed by a brief description of categories of implementations. A model Mobile learning framework and dynamic criteria for mobile learning implementations are proposed, along with a case study of one site…

  2. Building and Sustaining Complex Systems: Addressing Common Challenges to Implementing Intensive Intervention

    ERIC Educational Resources Information Center

    McInerney, Maurice; Zumeta, Rebecca O.; Gandhi, Allison G.; Gersten, Russell

    2014-01-01

    School and district personnel have identified common challenges in implementing individualized, intensive interventions for students with severe, persistent learning and behavioral needs. The National Center on Intensive Intervention has worked with scores of local educators--including district administrators, building principals, special and…

  3. Year of Coordinated Observations, Modeling and Forecasting: Addressing the Challenge of Organized Tropical Convection

    NASA Technical Reports Server (NTRS)

    Waliser, Duane E.

    2006-01-01

    The multi-scale organization of tropical convection and scale interaction are grand challenges in the prediction of weather and climate. As part of a international effort UN Year of Planet Earth, this proposed effort to observe, model and forecast the effects of organized tropical convection is reviewed. This viewgraph presentation reviews the proposal.

  4. Addressing the Challenges Special Needs Students Face when Transitioning from the Classroom to the Workplace

    ERIC Educational Resources Information Center

    Gagliardi, Frank

    2010-01-01

    One of the biggest fears and challenges a parent of a child with special needs faces is navigating the post-22 landscape. When a child hits the age of 22, the Department of Elementary and Secondary Education (DESE) is no longer required to provide daily services and support. Whatever the abilities, or disabilities, of a child, every parent has the…

  5. Family Connections: Helping Early Head Start/Head Start Staff and Parents Address Mental Health Challenges

    ERIC Educational Resources Information Center

    Beardslee, William R.; Avery, Mary Watson; Ayoub, Catherine; Watts, Caroline L.

    2009-01-01

    Early Head Start/Head Start teachers and staff encounter parents who have wrestled with depression and other adversities every day. This article describes an innovative program of trainings for and consultation to Early Head Start/Head Start staff to help them effectively deal with mental heath challenges faced by parents and children. The program…

  6. We Are All In This Together: Supporting Children's Social Emotional Development and Addressing Challenging Behavior

    ERIC Educational Resources Information Center

    Hemmeter, Mary Louise

    2007-01-01

    Many families of children with challenging behaviors have experienced multiple changes in child care because of their child's behavior. While this is disruptive for families, it has even more serious consequences for children. For these children, consistency and continuity is critical to their long term outcomes. In order to build the capacity of…

  7. Addressing Challenges in Web Accessibility for the Blind and Visually Impaired

    ERIC Educational Resources Information Center

    Guercio, Angela; Stirbens, Kathleen A.; Williams, Joseph; Haiber, Charles

    2011-01-01

    Searching for relevant information on the web is an important aspect of distance learning. This activity is a challenge for visually impaired distance learners. While sighted people have the ability to filter information in a fast and non sequential way, blind persons rely on tools that process the information in a sequential way. Learning is…

  8. Narrative Research Addressing the Challenges of a Career in Professional Sports

    ERIC Educational Resources Information Center

    Frankl, Daniel

    2013-01-01

    The purpose of this article is to highlight the challenges that accomplished young athletes face as they aspire to become professional athletes. The data used in this study was derived from selected lived and told sport experiences of undergraduate and graduate kinesiology majors who were former competitive athletes. Additional data was derived…

  9. Government Information Focus. The Digital Divide: Understanding and Addressing the Challenge.

    ERIC Educational Resources Information Center

    Latimer, Christopher P.

    This report discusses the challenges of the Digital Divide. Part I examines the issues concerning access as it relates to schools, communities, free Internet service providers, and broadband. Part II defines technological literacy and how it pertains to the Digital Divide debate. Part III examines those who are affected by the divide and…

  10. Addressing Human Capital Challenges: Assessing the Experiences of Four Countries in the Arab Region. Research Brief

    ERIC Educational Resources Information Center

    Gonzalez, Gabriella; Karoly, Lynn A.; Constant, Louay; Salem, Hanine; Goldman, Charles A.

    2008-01-01

    This research brief describes an analysis of the reform efforts of four Arab region nations (Lebanon, Oman, Qatar, the United Arab Emirates) in response to human capital challenges they face in preparing their people to work in a global environment. (Contains 3 tables.) [For associated report, see ED503118.

  11. The Benefits and Challenges of Becoming Cross-Culturally Competent Counseling Psychologists. Presidential Address

    ERIC Educational Resources Information Center

    Heppner, P. Paul

    2006-01-01

    The central thesis of this article is that focusing on cross-cultural competence will enhance both the science and the practice of counseling psychology. Developing cross-cultural competence is a lifelong journey, replete with many joys and challenges, that will (a) increase the sophistication of our research, (b) expand the utility and…

  12. Resources for Addressing Assessment and Accountability Challenges in Providing Services to Gifted Students

    ERIC Educational Resources Information Center

    Johnsen, Susan K.

    2013-01-01

    This column focuses on the challenge of assessment and accountability in providing services to gifted students.The new Common Core State Standards in mathematics and language arts require new assessments for measuring student progress. The gifted field must be a part of the conversation in designing these tools. The National Association for Gifted…

  13. A Promising Approach to Addressing America's Biggest Challenges. Needle-Moving Community Collaboratives

    ERIC Educational Resources Information Center

    Jolin, Michele; Schmitz, Paul; Seldon, Willa

    2012-01-01

    Communities face powerful challenges--a high-school dropout epidemic, youth unemployment, teen pregnancy--that require powerful solutions. In a climate of increasingly constrained resources, those solutions must help communities to achieve more with less. A new kind of community collaborative--an approach that aspires to significant,…

  14. Mapping the Future, Mapping Education: An Analysis of the 2011 State of the Union Address

    ERIC Educational Resources Information Center

    Collin, Ross

    2012-01-01

    This article presents a discourse analysis of President Barack Obama's 2011 State of the Union Address. Fredric Jameson's concepts of cognitive mapping, cultural revolution, and the unconscious are employed to examine the president's vision of educational and economic transformation. Ultimately, it is argued this vision evokes a world in which…

  15. Toward a Predictive Understanding of Earth’s Microbiomes to Address 21st Century Challenges

    PubMed Central

    Blaser, Martin J.; Cardon, Zoe G.; Cho, Mildred K.; Dangl, Jeffrey L.; Green, Jessica L.; Knight, Rob; Maxon, Mary E.; Northen, Trent R.; Pollard, Katherine S.

    2016-01-01

    ABSTRACT Microorganisms have shaped our planet and its inhabitants for over 3.5 billion years. Humankind has had a profound influence on the biosphere, manifested as global climate and land use changes, and extensive urbanization in response to a growing population. The challenges we face to supply food, energy, and clean water while maintaining and improving the health of our population and ecosystems are significant. Given the extensive influence of microorganisms across our biosphere, we propose that a coordinated, cross-disciplinary effort is required to understand, predict, and harness microbiome function. From the parallelization of gene function testing to precision manipulation of genes, communities, and model ecosystems and development of novel analytical and simulation approaches, we outline strategies to move microbiome research into an era of causality. These efforts will improve prediction of ecosystem response and enable the development of new, responsible, microbiome-based solutions to significant challenges of our time. PMID:27178263

  16. Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

    PubMed

    Chan, Hon Fai; Ma, Siying; Leong, Kam W

    2016-06-01

    Translation of any inventions into products requires manufacturing. Development of drug/gene/cell delivery systems will eventually face manufacturing challenges, which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive cost. Microfluidicu technologies present many advantages to improve the quality of drug/gene/cell delivery systems. They also offer the benefits of automation. What remains unclear is whether they can meet the scale-up requirement. In this perspective, we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems, formation of microscale drug/cell-encapsulated particles, generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/nano-fibers. We also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems. PMID:27047674

  17. Addressing the Challenges of a Quarter Century of Giscience Education: A Flexible Higher Education Curriculum Framework

    NASA Astrophysics Data System (ADS)

    Veenendaal, B.

    2014-04-01

    A wide range of geographic information science (GIScience) educational programs currently exist, the oldest now over 25 years. Offerings vary from those specifically focussed on geographic information science, to those that utilise geographic information systems in various applications and disciplines. Over the past two decades, there have been a number of initiatives to design curricula for GIScience, including the NCGIA Core Curriculum, GIS&T Body of Knowledge and the Geospatial Technology Competency Model developments. The rapid developments in geospatial technology, applications and organisations have added to the challenges that higher educational institutions face in order to ensure that GIScience education is relevant and responsive to the changing needs of students and industry. This paper discusses some of the challenges being faced in higher education in general, and GIScience education in particular, and outlines a flexible higher education curriculum framework for GIScience.

  18. Toward a Predictive Understanding of Earth's Microbiomes to Address 21st Century Challenges.

    PubMed

    Blaser, Martin J; Cardon, Zoe G; Cho, Mildred K; Dangl, Jeffrey L; Donohue, Timothy J; Green, Jessica L; Knight, Rob; Maxon, Mary E; Northen, Trent R; Pollard, Katherine S; Brodie, Eoin L

    2016-01-01

    Microorganisms have shaped our planet and its inhabitants for over 3.5 billion years. Humankind has had a profound influence on the biosphere, manifested as global climate and land use changes, and extensive urbanization in response to a growing population. The challenges we face to supply food, energy, and clean water while maintaining and improving the health of our population and ecosystems are significant. Given the extensive influence of microorganisms across our biosphere, we propose that a coordinated, cross-disciplinary effort is required to understand, predict, and harness microbiome function. From the parallelization of gene function testing to precision manipulation of genes, communities, and model ecosystems and development of novel analytical and simulation approaches, we outline strategies to move microbiome research into an era of causality. These efforts will improve prediction of ecosystem response and enable the development of new, responsible, microbiome-based solutions to significant challenges of our time. PMID:27178263

  19. Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

    PubMed Central

    Chan, Hon Fai; Ma, Siying; Leong, Kam W.

    2016-01-01

    Translation of any inventions into products requires manufacturing. Development of drug/gene/cell delivery systems will eventually face manufacturing challenges, which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive cost. Microfluidicu technologies present many advantages to improve the quality of drug/gene/cell delivery systems. They also offer the benefits of automation. What remains unclear is whether they can meet the scale-up requirement. In this perspective, we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems, formation of microscale drug/cell-encapsulated particles, generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/nano-fibers. We also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems. PMID:27047674

  20. The Euratom Fast Collar (EFC): A Safeguards Instrument Design to Address Future Fuel Measurement Challenges

    SciTech Connect

    Evans, Louise; Swinhoe, Martyn T.; Menlove, Howard O.; Browne, Michael C.

    2012-08-13

    Summary of this presentation: (1) EFC instrument design for {sup 235}U verification measurements issued to EURATOM to issue a call for commercial tender; (2) Achieved a fast (Cd mode) measurement with less than 2% relative uncertainty in the doubles neutron counting rate in 10 minutes using a standard source strength; (3) Assay time in fast mode consistent with the needs of an inspector; (4) Extended to realistic calibration range for modern fuel designs - Relatively insensitive to gadolinia content for fuel designs with up to 32 burnable poison rods and 15 wt % gadolinia concentration, which is a realistic maximum for modern PWR fuel; (5) Improved performance over the standard thermal neutron collar with greater than twice the efficiency of the original design; (6) Novel tube pattern to reduce the impact of accidental pile-up; and (7) Joint test of prototype unit - EURATOM-LANL.

  1. Challenges created by data dissemination and access restrictions when attempting to address community concerns: individual privacy versus public wellbeing

    PubMed Central

    Colquhoun, Amy; Aplin, Laura; Geary, Janis; Goodman, Karen J.; Hatcher, Juanita

    2012-01-01

    Background Population health data are vital for the identification of public health problems and the development of public health strategies. Challenges arise when attempts are made to disseminate or access anonymised data that are deemed to be potentially identifiable. In these situations, there is debate about whether the protection of an individual's privacy outweighs potentially beneficial public health initiatives developed using potentially identifiable information. While these issues have an impact at planning and policy levels, they pose a particular dilemma when attempting to examine and address community concerns about a specific health problem. Methods Research currently underway in northern Canadian communities on the frequency of Helicobacter pylori infection and associated diseases, such as stomach cancer, is used in this article to illustrate the challenges that data controls create on the ability of researchers and health officials to address community concerns. Results Barriers are faced by public health professionals and researchers when endeavouring to address community concerns; specifically, provincial cancer surveillance departments and community-driven participatory research groups face challenges related to data release or access that inhibit their ability to effectively address community enquiries. The resulting consequences include a limited ability to address misinformation or to alleviate concerns when dealing with health problems in small communities. Conclusions The development of communication tools and building of trusting relationships are essential components of a successful investigation into community health concerns. It may also be important to consider that public wellbeing may outweigh the value of individual privacy in these situations. As such, a re-evaluation of data disclosure policies that are applicable in these circumstances should be considered. PMID:22584511

  2. "The Future of Scholarly Inquiry in Music Education": 1996 Senior Researcher Award Acceptance Address.

    ERIC Educational Resources Information Center

    Yarbrough, Cornelia

    1996-01-01

    Provides a statistical profile of the current state of music research as well as recommendations for future research. These recommendations explore and define approaches including the acquisition of interdisciplinary knowledge and skills, the importance of philosophical inquiry, and the definition and isolation of variables affecting musical…

  3. An Overview of Interdisciplinary Research at Notre Dame Addressing "Grand Challenges" in the Midwest and Great Lakes Region

    NASA Astrophysics Data System (ADS)

    Hamlet, A. F.; Bolster, D.; Tank, J. L.; Hellmann, J.; Christopher, S. F.; Sharma, A.; Chiu, C. M.

    2014-12-01

    The Midwest and Great Lakes region face a number of "Grand Challenges" associated with climate, land use, agriculture, and water resources infrastructure. These include sustainability of agricultural systems and related impacts to food security and the regional economy; sustainability of Great Lakes water levels; changing storm statistics and impacts to stormwater management and flooding; water quality in rivers and downstream receiving water bodies related to non-point source pollution on agricultural lands and combined sewer overflows in urban areas; urban impacts related to aging infrastructure and climate change, and ecosystem management and restoration. In the context of water management, groundwater resources are poorly understood in comparison with surface water resources, and regional-scale simulation models are needed to address questions of sustainability both in terms of supply and water quality. Interdisciplinary research at the University of Notre Dame is attempting to address these research challenges via 1) integrated macro-scale groundwater and surface water modeling to address issues related to sustainable water supply, ecosystem restoration, and agricultural impacts; 2) development of high-resolution regional climate models dynamically coupled to the Great Lakes to address urban impacts, changing storm statistics and to quantify precipitation and evaporation over the Great Lakes; 3) and integrated macro-scale hydrology and water quality modeling to assess the large-scale performance of innovative land management BMPs on agricultural land (such as the two-stage ditch, cover crops, and dynamic drainage control) intended to improve water quality.

  4. Powering the Future: A Wind Turbine Design Challenge

    ERIC Educational Resources Information Center

    Pries, Caitlin Hicks; Hughes, Julie

    2011-01-01

    Nothing brings out the best in eighth-grade physical science students quite like an engineering challenge. The wind turbine design challenge described in this article has proved to be a favorite among students with its focus on teamwork and creativity and its (almost) sneaky reinforcement of numerous physics concepts. For this activity, pairs of…

  5. The challenge of health & environment: profiling risks & strategic priorities for now & the future.

    PubMed

    Narain, Jai P

    2012-08-01

    A substantial burden of communicable and non-communicable diseases in the developing countries is attributable to environmental risk factors. WHO estimates that the environmental factors are responsible for an estimated 24 per cent of the global burden of disease in terms of healthy life years lost and 23 per cent of all deaths; children being the worst sufferers. Given that the environment is linked with most of the Millennium Development Goals (MDGs), without proper attention to the environmental risk factors and their management, it will be difficult to achieve many MDGs by 2015. The impact of environmental degradation on health may continue well into the future and the situation in fact, is likely to get worse. In order to address this challenge, two facts are worth noting. First, that much of the environmental disease burden is attributable to a few critical risk factors which include unsafe water and sanitation, exposure to indoor smoke from cooking fuel, outdoor air pollution, exposure to chemicals such as arsenic, and climate change. Second, that environment and health aspects must become, as a matter of urgency, a national priority, both in terms of policy and resources allocation. To meet the challenge of health and environment now and in the future, the following strategic approaches must be considered which include conducting environmental and health impact assessments; strengthening national environmental health policy and infrastructure; fostering inter-sectoral co-ordination and partnerships; mobilizing public participation; and enhancing the leadership role of health in advocacy, stewardship and capacity building. PMID:22960884

  6. The challenge of health & environment: Profiling risks & strategic priorities for now & the future

    PubMed Central

    Narain, Jai P.

    2012-01-01

    A substantial burden of communicable and non-communicable diseases in the developing countries is attributable to environmental risk factors. WHO estimates that the environmental factors are responsible for an estimated 24 per cent of the global burden of disease in terms of healthy life years lost and 23 per cent of all deaths; children being the worst sufferers. Given that the environment is linked with most of the Millennium Development Goals (MDGs), without proper attention to the environmental risk factors and their management, it will be difficult to achieve many MDGs by 2015. The impact of environmental degradation on health may continue well into the future and the situation in fact, is likely to get worse. In order to address this challenge, two facts are worth noting. First, that much of the environmental disease burden is attributable to a few critical risk factors which include unsafe water and sanitation, exposure to indoor smoke from cooking fuel, outdoor air pollution, exposure to chemicals such as arsenic, and climate change. Second, that environment and health aspects must become, as a matter of urgency, a national priority, both in terms of policy and resources allocation. To meet the challenge of health and environment now and in the future, the following strategic approaches must be considered which include conducting environmental and health impact assessments; strengthening national environmental health policy and infrastructure; fostering inter-sectoral co-ordination and partnerships; mobilizing public participation; and enhancing the leadership role of health in advocacy, stewardship and capacity building. PMID:22960884

  7. Oral food challenges in children: review and future perspectives.

    PubMed

    Greenhawt, Matthew

    2011-12-01

    Food allergy is a lifelong condition with no known treatment or cure. Allergy tests such as skin tests and blood tests are not always accurate when positive and are not necessarily diagnostic of a food allergy. A food allergy takes into consideration both the history of exposure and the testing. The food challenge is considered the diagnostic gold standard for food allergy. However, recent evidence suggests that not enough challenges are being performed. Several techniques exist with which clinicians can challenge patients. Providers who perform challenges should be familiar with assessing signs and symptoms of a potential reaction and must be prepared to treat anaphylaxis. The magnitude of the serum and skin tests may be of assistance in stratifying a patient's risk of passing a challenge, and newer diagnostic tests may help better stratify such risk of based on particular epitope recognition. PMID:21901306

  8. Swimming upstream: the challenges and rewards of evaluating efforts to address inequities and reduce health disparities.

    PubMed

    Hughes, Dana; Docto, Lindsay; Peters, Jessica; Lamb, Anne Kelsey; Brindis, Claire

    2013-06-01

    Racial and ethnic disparities in the health of Americans are widespread and persistent in the United States despite improvements in the health of Americans overall. Increasingly, strategies for reducing disparities have focused on addressing the factors that contribute to - if not fundamentally underlie - health disparities: social, economic, and environmental inequities, which limit access to resources and cause unhealthy exposures. As public health shifts to interventions that seek to improve the circumstances of disproportionately affected populations and achieve equity through policy change, alternative methods to evaluate these efforts are also required. This paper presents an example of such approaches to addressing asthma disparities through Regional Asthma Management and Prevention's (RAMP) programmatic efforts and an evaluation of these activities. The paper describes RAMP's targets and strategies, as well as the specific evaluation methods applied to each, including activity tracking, observations, surveys, key informant interviews, and case studies. Preliminary evaluation findings are presented, as are lessons learned about the efficacy of the evaluation design features - both its strengths and shortcomings. Findings discussed are intended to contribute to the growing literature that provides evidence for the application of emerging approaches to evaluation that reflect non-traditional public health and support others interested in expanding or replicating this work. PMID:23416287

  9. Cancer Core Europe: a consortium to address the cancer care-cancer research continuum challenge.

    PubMed

    Eggermont, Alexander M M; Caldas, Carlos; Ringborg, Ulrik; Medema, René; Tabernero, Josep; Wiestler, Otmar

    2014-11-01

    European cancer research for a transformative initiative by creating a consortium of six leading excellent comprehensive cancer centres that will work together to address the cancer care-cancer research continuum. Prerequisites for joint translational and clinical research programs are very demanding. These require the creation of a virtual single 'e-hospital' and a powerful translational platform, inter-compatible clinical molecular profiling laboratories with a robust underlying computational biology pipeline, standardised functional and molecular imaging, commonly agreed Standard Operating Procedures (SOPs) for liquid and tissue biopsy procurement, storage and processing, for molecular diagnostics, 'omics', functional genetics, immune-monitoring and other assessments. Importantly also it requires a culture of data collection and data storage that provides complete longitudinal data sets to allow for: effective data sharing and common database building, and to achieve a level of completeness of data that is required for conducting outcome research, taking into account our current understanding of cancers as communities of evolving clones. Cutting edge basic research and technology development serve as an important driving force for innovative translational and clinical studies. Given the excellent track records of the six participants in these areas, Cancer Core Europe will be able to support the full spectrum of research required to address the cancer research- cancer care continuum. Cancer Core Europe also constitutes a unique environment to train the next generation of talents in innovative translational and clinical oncology. PMID:25263570

  10. On the road to a stronger public health workforce: visual tools to address complex challenges.

    PubMed

    Drehobl, Patricia; Stover, Beth H; Koo, Denise

    2014-11-01

    The public health workforce is vital to protecting the health and safety of the public, yet for years, state and local governmental public health agencies have reported substantial workforce losses and other challenges to the workforce that threaten the public's health. These challenges are complex, often involve multiple influencing or related causal factors, and demand comprehensive solutions. However, proposed solutions often focus on selected factors and might be fragmented rather than comprehensive. This paper describes approaches to characterizing the situation more comprehensively and includes two visual tools: (1) a fishbone, or Ishikawa, diagram that depicts multiple factors affecting the public health workforce; and (2) a roadmap that displays key elements-goals and strategies-to strengthen the public health workforce, thus moving from the problems depicted in the fishbone toward solutions. The visual tools aid thinking about ways to strengthen the public health workforce through collective solutions and to help leverage resources and build on each other's work. The strategic roadmap is intended to serve as a dynamic tool for partnership, prioritization, and gap assessment. These tools reflect and support CDC's commitment to working with partners on the highest priorities for strengthening the workforce to improve the public's health. PMID:25439245

  11. Challenges for Future UV Imaging of the Earth's Ionosphere and High Latitude Regions

    NASA Technical Reports Server (NTRS)

    Spann, James

    2006-01-01

    Large scale imaging of Geospace has played a significant role in the recent advances in the comprehension of the coupled Solar-Terrestrial System. The Earth's ionospheric far ultraviolet emissions provide a rich tapestry of observations that play a key role in sorting out the dominant mechanisms and phenomena associated with the coupling of the ionosphere and magnetosphere (MI). The MI coupling is an integral part of the Solar-Terrestrial and as such, future observations in this region should focus on understanding the coupling and the impact of solar variability. This talk will focus on the outstanding problems associated with the coupled Solar-Terrestrial system that can be best addressed using far ultraviolet imaging of the Earthls ionosphere. Challenges of global scale imaging and high-resolution imaging will be discussed and how these are driven by unresolved compelling science questions of magnetospheric configuration, and auroral dynamics.

  12. Carbonic anhydrase mediated carbon dioxide sequestration: promises, challenges and future prospects.

    PubMed

    Yadav, Raju R; Krishnamurthi, Kannan; Mudliar, Sandeep N; Devi, S Saravana; Naoghare, Pravin K; Bafana, Amit; Chakrabarti, Tapan

    2014-06-01

    Anthropogenic activities have substantially increased the level of greenhouse gases (GHGs) in the atmosphere and are contributing significantly to the global warming. Carbon dioxide (CO2 ) is one of the major GHGs which plays a key role in the climate change. Various approaches and methodologies are under investigation to address CO2 capture and sequestration worldwide. Carbonic anhydrase (CA) mediated CO2 sequestration is one of the promising options. Therefore, the present review elaborates recent developments in CA, its immobilization and bioreactor methodologies towards CO2 sequestration using the CA enzyme. The promises and challenges associated with the efficient utilization of CA for CO2 sequestration and scale up from flask to lab-scale bioreactor are critically discussed. Finally, the current review also recommends the possible future needs and directions to utilize CA for CO2 sequestration. PMID:24740638

  13. Non-governmental organizations in international health: past successes, future challenges.

    PubMed

    Gellert, G A

    1996-01-01

    Non-governmental organizations, or NGOs, are increasingly instrumental to the implementation of international health programs. Following an overview of current conditions in global health and the problems that could be targeted by NGOs, this article describes the activities and philosophies of several representative approaches in this sector. The attributes of NGOs that increase their potential effectiveness are discussed, including ability to reach areas of severe need, promotion of local involvement, low cost of operations, adaptiveness and innovation, independence, and sustainability. A summary is provided of major future challenges in international health that may be addressed by NGOs, with particular emphasis on tobacco-related disease, communicable diseases and the AIDS epidemic, maternal mortality and women's health, injury prevention and control, and the need to secure durable financial support. PMID:10157062

  14. Developing technology-enhanced active learning for medical education: challenges, solutions, and future directions.

    PubMed

    McCoy, Lise; Pettit, Robin K; Lewis, Joy H; Bennett, Thomas; Carrasco, Noel; Brysacz, Stanley; Makin, Inder Raj S; Hutman, Ryan; Schwartz, Frederic N

    2015-04-01

    Growing up in an era of video games and Web-based applications has primed current medical students to expect rapid, interactive feedback. To address this need, the A.T. Still University-School of Osteopathic Medicine in Arizona (Mesa) has developed and integrated a variety of approaches using technology-enhanced active learning for medical education (TEAL-MEd) into its curriculum. Over the course of 3 years (2010-2013), the authors facilitated more than 80 implementations of games and virtual patient simulations into the education of 550 osteopathic medical students. The authors report on 4 key aspects of the TEAL-MEd initiative, including purpose, portfolio of tools, progress to date regarding challenges and solutions, and future directions. Lessons learned may be of benefit to medical educators at academic and clinical training sites who wish to implement TEAL-MEd activities. PMID:25830576

  15. Information resources for assessing health effects from chemical exposure: Challenges, priorities, and future issues

    SciTech Connect

    Seigel, S.

    1990-12-31

    Issues related to developing information resources for assessing the health effects from chemical exposure include the question of how to address the individual political issues relevant to identifying and determining the timeliness, scientific credibility, and completeness of such kinds of information resources. One of the important ways for agencies to share information is through connection tables. This type of software is presently being used to build information products for some DHHS agencies. One of the challenges will be to convince vendors of data of the importance of trying to make data files available to communities that need them. In the future, information processing will be conducted with neural networks, object-oriented database management systems, and fuzzy-set technologies, and meta analysis techniques.

  16. IT-enabled Community Health Interventions: Challenges, Opportunities, and Future Directions

    PubMed Central

    Kharrazi, Hadi; Weiner, Jonathan P.

    2014-01-01

    Rising health information technology (HIT) adoption and the increasing interoperability of health data have propelled the role of IT in community-wide health transformations. Disseminating the challenges and opportunities that the early adopters of community-wide HIT interventions have experienced is critical for empowering the growing demand for community-based health systems. This special issue of eGEMs addresses that need. This issue includes a variety of community-based HIT projects covering topics such as governance, informatics, and learning health systems. These projects represent a diverse set of stakeholders, a wide selection of data sources, and multiple information platforms to collate or exchange data. We hope that this special issue of eGEMs will be the first of several future issues dedicated to community-wide HIT transformations. PMID:25848627

  17. Key issues in space nuclear power challenges for the future

    NASA Technical Reports Server (NTRS)

    Brandhorst, Henry W., Jr.

    1991-01-01

    The future appears rich in missions that will extend the frontiers of knowledge, human presence in space, and opportunities for profitable commerce. Key to the success of these ventures is the availability of plentiful, cost effective electric power and assured, low cost access to space. While forecasts of space power needs are problematic, an assessment of future needs based on terrestrial experience has been made. These needs fall into three broad categories: survival, self sufficiency, and industrialization. The cost of delivering payloads to orbital locations from LEO to Mars has been determined and future launch cost reductions projected. From these factors, then, projections of the performance necessary for future solar and nuclear space power options has been made. These goals are largely dependent upon orbital location and energy storage needs. Finally the cost of present space power systems has been determined and projections made for future systems.

  18. The future of human embryonic stem cell research: addressing ethical conflict with responsible scientific research.

    PubMed

    Gilbert, David M

    2004-05-01

    Embryonic stem (ES) cells have almost unlimited regenerative capacity and can potentially generate any body tissue. Hence they hold great promise for the cure of degenerative human diseases. But their derivation and the potential for misuse have raised a number of ethical issues. These ethical issues threaten to paralyze pubic funding for ES cell research, leaving experimentation in the hands of the private sector and precluding the public's ability to monitor practices, research alternatives, and effectively address the very ethical issues that are cause for concern in the first place. With new technology being inevitable, and the potential for abuse high, government must stay involved if the public is to play a role in shaping the direction of research. In this essay, I will define levels of ethical conflict that can be delineated by the anticipated advances in technology. From the urgent need to derive new ES cell lines with existing technology, to the most far-reaching goal of deriving genetically identical tissues from an adult patients cells, technology-specific ethical dilemmas can be defined and addressed. This staged approach provides a solid ethical framework for moving forward with ES cell research. Moreover, by anticipating the moral conflicts to come, one can predict the types of scientific advances that could overcome these conflicts, and appropriately direct federal funding toward these goals to offset potentially less responsible research directives that will inevitably go forward via private or foreign funding. PMID:15114283

  19. Replicating a self-affirmation intervention to address gender differences: Successes and challenges

    NASA Astrophysics Data System (ADS)

    Kost-Smith, Lauren E.; Pollock, Steven J.; Finkelstein, Noah D.; Cohen, Geoffrey L.; Ito, Tiffany A.; Miyake, Akira

    2012-02-01

    We previously reported on the success of a psychological intervention implemented to reduce gender differences in achievement in an introductory college physics course. In this prior study, we found that the gender gap on exams and the FMCE among students who completed two 15-minute self-affirmation writing exercises was significantly reduced compared to the gender gap among students who completed neutral writing exercises. In a follow-up study we replicated the self-affirmation intervention in a later semester of the same course, with the same instructor. In this paper, we report the details and preliminary results of the replication study, where we find similar patterns along exams and course grades, but do not observe these patterns along the FMCE. We begin to investigate the critical features of replicating educational interventions, finding that replicating educational interventions is challenging, complex, and involves potentially subtle factors, some of which we explore and others that require further research.

  20. An introduction to electronic learning and its use to address challenges in surgical training.

    PubMed

    Baran, Szczepan W; Johnson, Elizabeth J; Kehler, James

    2009-06-01

    The animal research community faces a shortage of surgical training opportunities along with an increasing demand for expertise in surgical techniques. One possible means of overcoming this challenge is the use of computer-based or electronic learning (e-learning) to disseminate material to a broad range of animal users. E-learning platforms can take many different forms, ranging from simple text documents that are posted online to complex virtual courses that incorporate dynamic video or audio content and in which students and instructors can interact in real time. The authors present an overview of e-learning and discuss its potential benefits as a supplement to hands-on rodent surgical training. They also discuss a few basic considerations in developing and implementing electronic courses. PMID:19455166

  1. ENERGY EFFICIENCY CHALLENGES ADDRESSED THROUGH THE USE OF ADVANCED REFRACTORY CERAMIC MATERIALS

    SciTech Connect

    Hemrick, James Gordon

    2014-01-01

    Refractory ceramics can play a critical role in improving the energy efficiency of traditional industrial processes through increased furnace efficiency brought about by the employment of novel refractory systems and techniques. Examples of advances in refractory materials related to aluminum, gasification, glass, and lime are highlighted. Energy savings are realized based on reduction of chemical reactions, elimination of mechanical degradation caused by the service environment, reduction of temperature limitations of materials, and elimination of costly installation and repair needs. Key results of projects resulting from US Department of Energy (DOE) funded research programs are discussed with emphasis on applicability of these results to high temperature furnace applications and needed research directions for the future.

  2. DIII-D research to address key challenges for ITER and fusion energy

    NASA Astrophysics Data System (ADS)

    Buttery, R. J.; the DIII-D Team

    2015-10-01

    DIII-D has made significant advances in the scientific basis for fusion energy. The physics mechanism of resonant magnetic perturbation (RMP) edge localized mode (ELM) suppression is revealed as field penetration at the pedestal top, and reduced coil set operation was demonstrated. Disruption runaway electrons were effectively quenched by shattered pellets; runaway dissipation is explained by pitch angle scattering. Modest thermal quench radiation asymmetries are well described NIMROD modelling. With good pedestal regulation and error field correction, low torque ITER baselines have been demonstrated and shown to be compatible with an ITER test blanket module simulator. However performance and long wavelength turbulence degrade as low rotation and electron heating are approached. The alternative QH mode scenario is shown to be compatible with high Greenwald density fraction, with an edge harmonic oscillation demonstrating good impurity flushing. Discharge optimization guided by the EPED model has discovered a new super H-mode with doubled pedestal height. Lithium injection also led to wider, higher pedestals. On the path to steady state, 1 MA has been sustained fully noninductively with βN = 4 and RMP ELM suppression, while a peaked current profile scenario provides attractive options for ITER and a βN = 5 future reactor. Energetic particle transport is found to exhibit a critical gradient behaviour. Scenarios are shown to be compatible with radiative and snowflake divertor techniques. Physics studies reveal that the transition to H mode is locked in by a rise in ion diamagnetic flows. Intrinsic rotation in the plasma edge is demonstrated to arise from kinetic losses. New 3D magnetic sensors validate linear ideal MHD, but identify issues in nonlinear simulations. Detachment, characterized in 2D with sub-eV resolution, reveals a radiation shortfall in simulations. Future facility development targets burning plasma physics with torque free electron heating, the

  3. Soil Contamination and Remediation Strategies. Current research and future challenge

    NASA Astrophysics Data System (ADS)

    Petruzzelli, G.

    2012-04-01

    eliminating the source of pollution, but also on blocking the pathways from contaminants to receptors or reducing the exposure to contaminants,. Future challenge integration of sustainability into remediation decision-making. Soil is not a waste! There is a growing interest in the clean up approaches that maintain soil quality after remediation treatments. This issue is of great importance in the U.S.A. where the EPA from 2009 is promoting innovative clean-up strategies (Green Remediation). Green remediation is defined as the practice of considering all environmental effects of remedy and incorporating options to maximize environmental benefit of cleanup actions . These remediation strategies restore contaminated sites to productive use with a great attention to the global environmental quality, including the preservation of soil functionality according to the following principles: use minimally invasive technologies; use passive energy technologies such as bioremediation and phytoremediation as primary remedies or finishing steps where possible and effective; minimize soil and habitat disturbance; minimize bioavailability of contaminants trough adequate contaminant source and plume control If we move from the current definition of remedial targets based on total concentrations, technologies with low impact on the environment can be utilized reducing the wrong choice to disposal soil in landfill destroying quickly a not renewable essential resource.

  4. Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks.

    PubMed

    Haque, Azizul; Hober, Didier; Blondiaux, Joel

    2015-10-01

    Ebola virus can cause severe hemorrhagic disease with high fatality rates. Currently, no specific therapeutic agent or vaccine has been approved for treatment and prevention of Ebola virus infection of humans. Although the number of Ebola cases has fallen in the last few weeks, multiple outbreaks of Ebola virus infection and the likelihood of future exposure highlight the need for development and rapid evaluation of pre- and postexposure treatments. Here, we briefly review the existing and future options for anti-Ebola therapy, based on the data coming from rare clinical reports, studies on animals, and results from in vitro models. We also project the mechanistic hypotheses of several potential drugs against Ebola virus, including small-molecule-based drugs, which are under development and being tested in animal models or in vitro using various cell types. Our paper discusses strategies toward identifying and testing anti-Ebola virus properties of known and medically approved drugs, especially those that can limit the pathological inflammatory response in Ebola patients and thereby provide protection from mortality. We underline the importance of developing combinational therapy for better treatment outcomes for Ebola patients. PMID:26248374

  5. Addressing Future Epidemics: Historical Human Rights Lessons from the AIDS Pandemic

    PubMed Central

    Mehta, Ambar; Quinn, Thomas C.

    2016-01-01

    Introduction The Ebola epidemic in West Africa sparked many ethical and polarizing public health questions on how to adequately control transmission of the virus. These deliberations had and will continue to influence patients, healthcare workers, public perceptions of disease, and governmental responses. Such extensive and potential ramifications warranted an analysis of prior epidemics to sufficiently inform policy makers and prepare them and other authorities for future epidemics. We analyzed how the general public, medical institutions, federal government, and patients themselves responded during the early stages of the AIDS pandemic in two different countries and cultures, the United States and India. Discussion Our analysis identified four key findings pertaining to the human rights of patients and healthcare workers and to the crucial roles of the government and medical community. The first demands that authoritative officials acknowledge the presence of high-risk behaviors and properly educate the public without stigmatizing groups of individuals. For this task, the medical community and federal government must form and display to the public a respectful and collaborative partnership towards battling the epidemic. These two synergistic endeavors will then allow appropriate officials to implement effective, yet civil, interventions for limiting transmission. Finally, the same officials must ensure that their interventions maintain the human rights of high-risk populations and of healthcare workers. Conclusions Applying these findings to future epidemics of infectious diseases can aid policy makers in navigating complicated ethical and public health questions, and help prevent them from repeating past mistakes in handling epidemics. PMID:27284578

  6. Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks

    PubMed Central

    Hober, Didier; Blondiaux, Joel

    2015-01-01

    Ebola virus can cause severe hemorrhagic disease with high fatality rates. Currently, no specific therapeutic agent or vaccine has been approved for treatment and prevention of Ebola virus infection of humans. Although the number of Ebola cases has fallen in the last few weeks, multiple outbreaks of Ebola virus infection and the likelihood of future exposure highlight the need for development and rapid evaluation of pre- and postexposure treatments. Here, we briefly review the existing and future options for anti-Ebola therapy, based on the data coming from rare clinical reports, studies on animals, and results from in vitro models. We also project the mechanistic hypotheses of several potential drugs against Ebola virus, including small-molecule-based drugs, which are under development and being tested in animal models or in vitro using various cell types. Our paper discusses strategies toward identifying and testing anti-Ebola virus properties of known and medically approved drugs, especially those that can limit the pathological inflammatory response in Ebola patients and thereby provide protection from mortality. We underline the importance of developing combinational therapy for better treatment outcomes for Ebola patients. PMID:26248374

  7. Status of Global Threat Reduction Initiative's Activities Underway to Address Major Domestic Radiological Security Challenges - 12105

    SciTech Connect

    Cuthbertson, Abigail; Jennison, Meaghan

    2012-07-01

    During their service lives, radioactive sealed sources are used for a wide variety of essential purposes. However, each year, thousands of radioactive sealed sources that pose a potential risk to national security, health, and safety become disused and unwanted in the United States. Due to their concentrated activity and portability, these sources could be used in radiological dispersal devices ('dirty bombs'). For more than a decade, the National Nuclear Security Administration and the U.S. Department of Energy, through the Global Threat Reduction Initiative Offsite Source Recovery Project (GTRI/OSRP), have facilitated the removal and disposition of thousands of disused/unwanted sources worldwide. However, the ability of GTRI/OSRP to continue its work is critically dependent on the ability to transport and appropriately dispose of these sources. On that front, GTRI/OSRP progress includes development of two prototype Type B transport containers and significant efforts toward certification, increased commercial disposal access for risk-significant sealed sources at commercial sites, and cooperation through the International Atomic Energy Agency to increase source repatriation. Disused sealed sources continue to pose a national security concern. The impact of a dirty bomb detonation could be costly both financially and to those exposed to the resulting radiation. However, significant progress has been made since 2008 on each of the challenges identified in the DHS Sealed Source Security Workshop. Not only will there be increased opportunity for commercial disposal of many sizes and types of sealed sources, but also stakeholders are studying front-end solutions to the problem of disused sealed sources, such as financial assurance and recycle. The lack of sealed source transport containers is also likely to be mitigated with the development and certification by NNSA of two new Type B models. Internationally, increased efforts at source repatriation will mitigate the

  8. The future water environment--using scenarios to explore the significant water management challenges in England and Wales to 2050.

    PubMed

    Henriques, C; Garnett, K; Weatherhead, E K; Lickorish, F A; Forrow, D; Delgado, J

    2015-04-15

    Society gets numerous benefits from the water environment. It is crucial to ensure that water management practices deliver these benefits over the long-term in a sustainable and cost-effective way. Currently, hydromorphological alterations and nutrient enrichment pose the greatest challenges in European water bodies. The rapidly changing climatic and socio-economic boundary conditions pose further challenges to water management decisions and the achievement of policy goals. Scenarios are a strategic tool useful in conducting systematic investigations of future uncertainties pertaining to water management. In this study, the use of scenarios revealed water management challenges for England and Wales to 2050. A set of existing scenarios relevant to river basin management were elaborated through stakeholder workshops and interviews, relying on expert knowledge to identify drivers of change, their interdependencies, and influence on system dynamics. In a set of four plausible alternative futures, the causal chain from driving forces through pressures to states, impacts and responses (DPSIR framework) was explored. The findings suggest that scenarios driven by short-term economic growth and competitiveness undermine current environmental legislative requirements and exacerbate the negative impacts of climate change, producing a general deterioration of water quality and physical habitats, as well as reduced water availability with adverse implications for the environment, society and economy. Conversely, there are substantial environmental improvements under the scenarios characterised by long-term sustainability, though achieving currently desired environmental outcomes still poses challenges. The impacts vary across contrasting generic catchment types that exhibit distinct future water management challenges. The findings suggest the need to address hydromorphological alterations, nutrient enrichment and nitrates in drinking water, which are all likely to be

  9. PM₂.₅ opened a door to public participation addressing environmental challenges in China.

    PubMed

    Huang, Ganlin

    2015-02-01

    China has long been regarded as a centralized society where the public has little influence on decision-making. Such a top-down management scheme is perceived as a major obstacle to address complicated environment issues. The recent public campaign in China to urge creation of a nationwide PM₂.₅ monitoring network and mitigation plan provides an unprecedented case of how the public participated and influenced policy-making in a centralized society. This paper reviews key incidents in the campaign chronologically. Here we identify information technology, public awareness of air quality's health impacts and the fact air quality affects everyone as public goods as the major factors promoting public participation. This case demonstrates that public participation can happen in a centralized, top-down society such as China. Continued environmental deterioration may stimulate similar campaigns for other issues. We anticipate this essay to be a starting point for more studies on how environmental issues stimulate incremental social change by making people involved in decision-making process, especially in societies where they are rarely able to do so. PMID:25499795

  10. Challenges in Renewable Natural Resources: A Guide to Alternative Futures.

    ERIC Educational Resources Information Center

    Theobald, Robert

    First presented at a United States Department of Agriculture (USDA) conference on renewable resources, this material includes information and discussion on critical issues, policies, and future alternatives for natural resources in the United States. (CO)

  11. Addressing the Challenges of Anomaly Detection for Cyber Physical Energy Grid Systems

    SciTech Connect

    Ferragut, Erik M; Laska, Jason A; Melin, Alexander M; Czejdo, Bogdan

    2013-01-01

    The consolidation of cyber communications networks and physical control systems within the energy smart grid introduces a number of new risks. Unfortunately, these risks are largely unknown and poorly understood, yet include very high impact losses from attack and component failures. One important aspect of risk management is the detection of anomalies and changes. However, anomaly detection within cyber security remains a difficult, open problem, with special challenges in dealing with false alert rates and heterogeneous data. Furthermore, the integration of cyber and physical dynamics is often intractable. And, because of their broad scope, energy grid cyber-physical systems must be analyzed at multiple scales, from individual components, up to network level dynamics. We describe an improved approach to anomaly detection that combines three important aspects. First, system dynamics are modeled using a reduced order model for greater computational tractability. Second, a probabilistic and principled approach to anomaly detection is adopted that allows for regulation of false alerts and comparison of anomalies across heterogeneous data sources. Third, a hierarchy of aggregations are constructed to support interactive and automated analyses of anomalies at multiple scales.

  12. Vision for cross-layer optimization to address the dual challenges of energy and reliability

    SciTech Connect

    Quinn, Heather M; Dehon, Andre; Carter, Nicholas P

    2009-01-01

    We are rapidly approaching an inflection point where the conventional target of producing perfect, identical transistors that operate without upset can no longer be maintained while continuing to reduce the energy per operation. With power requirements already limiting chip performance, continuing to demand perfect, upset-free transistors would mean the end of scaling benefits. The big challenges in device variability and reliability are driven by uncommon tails in distributions, infrequent upsets, one-size-fits-all technology requirements, and a lack of information about the context of each operation. Solutions co-designed across traditional layer boundaries in our system stack can change the game, allowing architecture and software (a) to compensate for uncommon variation, environments, and events, (b) to pass down invariants and requirements for the computation, and (c) to monitor the health of collections of deVices. Cross-layer codesign provides a path to continue extracting benefits from further scaled technologies despite the fact that they may be less predictable and more variable. While some limited multi-layer mitigation strategies do exist, to move forward redefining traditional layer abstractions and developing a framework that facilitates cross-layer collaboration is necessary.

  13. Addressing everyday challenges: feasibility of a family caregiver training program for people with dementia.

    PubMed

    DiZazzo-Miller, Rosanne; Samuel, Preethy S; Barnas, Jean M; Welker, Keith M

    2014-01-01

    OBJECTIVE. The purpose of this study was to examine the feasibility and efficacy of the Family Caregiver Training Program for assisting with the basic activities of daily living of people with dementia. METHOD. A one-group pretest-posttest research design with a 3-mo follow-up was used to examine the efficacy of a manualized education program for caregivers. The 6-hr training was delivered to 72 family caregivers over 3 consecutive weeks (2 hr/wk) by trained clinicians. RESULTS. Caregivers showed a significant gain in knowledge of how to effectively assist with communication and nutrition, t(52) = 7.05, p < .000; transfers and toileting, t(45) = 3.10, p < .003; and bathing and dressing, t(44) = 2.71, p < .01, of their care recipients. CONCLUSION. Our findings demonstrate that this manualized intervention protocol is a promising method of equipping family members with the skills needed to face their everyday challenges in caring for people with dementia. PMID:24581408

  14. Addressing fundamental architectural challenges of an activity-based intelligence and advanced analytics (ABIAA) system

    NASA Astrophysics Data System (ADS)

    Yager, Kevin; Albert, Thomas; Brower, Bernard V.; Pellechia, Matthew F.

    2015-06-01

    The domain of Geospatial Intelligence Analysis is rapidly shifting toward a new paradigm of Activity Based Intelligence (ABI) and information-based Tipping and Cueing. General requirements for an advanced ABIAA system present significant challenges in architectural design, computing resources, data volumes, workflow efficiency, data mining and analysis algorithms, and database structures. These sophisticated ABI software systems must include advanced algorithms that automatically flag activities of interest in less time and within larger data volumes than can be processed by human analysts. In doing this, they must also maintain the geospatial accuracy necessary for cross-correlation of multi-intelligence data sources. Historically, serial architectural workflows have been employed in ABIAA system design for tasking, collection, processing, exploitation, and dissemination. These simpler architectures may produce implementations that solve short term requirements; however, they have serious limitations that preclude them from being used effectively in an automated ABIAA system with multiple data sources. This paper discusses modern ABIAA architectural considerations providing an overview of an advanced ABIAA system and comparisons to legacy systems. It concludes with a recommended strategy and incremental approach to the research, development, and construction of a fully automated ABIAA system.

  15. Strategies for Integrated Analysis of Genetic, Epigenetic, and Gene Expression Variation in Cancer: Addressing the Challenges

    PubMed Central

    Thingholm, Louise B.; Andersen, Lars; Makalic, Enes; Southey, Melissa C.; Thomassen, Mads; Hansen, Lise Lotte

    2016-01-01

    The development and progression of cancer, a collection of diseases with complex genetic architectures, is facilitated by the interplay of multiple etiological factors. This complexity challenges the traditional single-platform study design and calls for an integrated approach to data analysis. However, integration of heterogeneous measurements of biological variation is a non-trivial exercise due to the diversity of the human genome and the variety of output data formats and genome coverage obtained from the commonly used molecular platforms. This review article will provide an introduction to integration strategies used for analyzing genetic risk factors for cancer. We critically examine the ability of these strategies to handle the complexity of the human genome and also accommodate information about the biological and functional interactions between the elements that have been measured—making the assessment of disease risk against a composite genomic factor possible. The focus of this review is to provide an overview and introduction to the main strategies and to discuss where there is a need for further development. PMID:26870081

  16. Addressing the Real-World Challenges in the Development of Propulsion IVHM Technology Experiment (PITEX)

    NASA Technical Reports Server (NTRS)

    Maul, William A.; Chicatelli, Amy; Fulton, Christopher E.; Balaban, Edward; Sweet, Adam; Hayden, Sandra Claire; Bajwa, Anupa

    2005-01-01

    The Propulsion IVHM Technology Experiment (PITEX) has been an on-going research effort conducted over several years. PITEX has developed and applied a model-based diagnostic system for the main propulsion system of the X-34 reusable launch vehicle, a space-launch technology demonstrator. The application was simulation-based using detailed models of the propulsion subsystem to generate nominal and failure scenarios during captive carry, which is the most safety-critical portion of the X-34 flight. Since no system-level testing of the X-34 Main Propulsion System (MPS) was performed, these simulated data were used to verify and validate the software system. Advanced diagnostic and signal processing algorithms were developed and tested in real-time on flight-like hardware. In an attempt to expose potential performance problems, these PITEX algorithms were subject to numerous real-world effects in the simulated data including noise, sensor resolution, command/valve talkback information, and nominal build variations. The current research has demonstrated the potential benefits of model-based diagnostics, defined the performance metrics required to evaluate the diagnostic system, and studied the impact of real-world challenges encountered when monitoring propulsion subsystems.

  17. Addressing the Numerical Challenges Associated With Laser-Induced Melt Convection

    NASA Astrophysics Data System (ADS)

    Weston, Brian; Nourgaliev, Robert; Delplanque, Jean Pierre; Anderson, Andy

    2015-11-01

    We present a new robust and efficient numerical framework for simulating multi-material flows with phase change. The work is motivated by laser-induced phase change applications, particularly the selective laser melting (SLM) process in additive manufacturing. Physics-based simulations of the laser melt dynamics requires a fully compressible framework, since incompressible flow solvers are inefficient for stiff systems, arising from laser-induced rapid phase change. In this study, the liquid and solid phases are both modeled with the compressible Navier-Stokes equations. The solid phase has an additional combined variable viscosity and drag force model to suppress the velocity in the solid. Our all-speed Navier-Stokes solver is based on a fully-implicit, high-order reconstructed Discontinuous Galerkin method. A Newton-Krylov based framework is used to solve the resulting set of non-linear equations, enabling robust simulations of the highly stiff compressible Navier-Stokes equations. We demonstrate the method's capabilities for phase change on several different melting and freezing configurations, including a three-dimensional laser-induced melt convection problem. Future model enhancements will incorporate material evaporation and rapid solidification.

  18. Development of irradiation capabilities to address the challenges of the nuclear industry

    NASA Astrophysics Data System (ADS)

    Leay, L.; Bower, W.; Horne, G.; Wady, P.; Baidak, A.; Pottinger, M.; Nancekievill, M.; Smith, A. D.; Watson, S.; Green, P. R.; Lennox, B.; LaVerne, J. A.; Pimblott, S. M.

    2015-01-01

    With the announcement of the U.K. new nuclear build and the requirement to decommission old facilities, researchers require bespoke facilities to undertake experiments to inform decision making. This paper describes development of The University of Manchester's Dalton Cumbrian Facility, a custom built research environment which incorporates a 5 MV tandem ion accelerator as well as a self-shielded 60Co irradiator. The ion accelerator allows the investigation into the radiolytic consequences of various charged particles, including protons, alpha particles and a variety of heavier (metal and nonmetal) ions, while the 60Co irradiator allows the effects of gamma radiation to be studied. Some examples of work carried out at the facility are presented to demonstrate how this equipment can improve our mechanistic understanding of various aspects of the deleterious effects of radiation in the nuclear industry. These examples include applications in waste storage and reprocessing as well as geological storage and novel surveying techniques. The outlook for future research is also discussed.

  19. Technical Reference Suite Addressing Challenges of Providing Assurance for Fault Management Architectural Design

    NASA Technical Reports Server (NTRS)

    Fitz, Rhonda; Whitman, Gerek

    2016-01-01

    Research into complexities of software systems Fault Management (FM) and how architectural design decisions affect safety, preservation of assets, and maintenance of desired system functionality has coalesced into a technical reference (TR) suite that advances the provision of safety and mission assurance. The NASA Independent Verification and Validation (IV&V) Program, with Software Assurance Research Program support, extracted FM architectures across the IV&V portfolio to evaluate robustness, assess visibility for validation and test, and define software assurance methods applied to the architectures and designs. This investigation spanned IV&V projects with seven different primary developers, a wide range of sizes and complexities, and encompassed Deep Space Robotic, Human Spaceflight, and Earth Orbiter mission FM architectures. The initiative continues with an expansion of the TR suite to include Launch Vehicles, adding the benefit of investigating differences intrinsic to model-based FM architectures and insight into complexities of FM within an Agile software development environment, in order to improve awareness of how nontraditional processes affect FM architectural design and system health management. The identification of particular FM architectures, visibility, and associated IV&V techniques provides a TR suite that enables greater assurance that critical software systems will adequately protect against faults and respond to adverse conditions. Additionally, the role FM has with regard to strengthened security requirements, with potential to advance overall asset protection of flight software systems, is being addressed with the development of an adverse conditions database encompassing flight software vulnerabilities. Capitalizing on the established framework, this TR suite provides assurance capability for a variety of FM architectures and varied development approaches. Research results are being disseminated across NASA, other agencies, and the

  20. 2015 Presidential Address: 75 Years of Battling Diabetes--Our Global Challenge.

    PubMed

    Dagogo-Jack, Samuel

    2016-01-01

    This address was delivered by Samuel Dagogo-Jack, MD, President, Medicine & Science, of the American Diabetes Association (ADA), at the Association's 75th Scientific Sessions in Boston, MA, on 7 June 2015. Dr. Dagogo-Jack is a professor of medicine and the director of the Division of Endocrinology, Diabetes and Metabolism and the director of the Clinical Research Center at The University of Tennessee Health Science Center, Memphis, TN, where he holds the A.C. Mullins Endowed Chair in Translational Research. He has been an ADA volunteer since 1991 and has served on several national committees and chaired the Association's Research Grant Review Committee. At the local level, he has served on community leadership boards in St. Louis, MO, and Tennessee. A physician-scientist, Dr. Dagogo-Jack's current research focuses on the interaction of genetic and environmental factors in the prediction and prevention of prediabetes, diabetes, and diabetes complications. He is the principal investigator of the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study and also directs The University of Tennessee site for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and the Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS). Dr. Dagogo-Jack earned his medical and research doctorate degrees from the University of Ibadan College of Medicine in Nigeria, holds a master's of science from the University of Newcastle upon Tyne in England, and completed his postdoctoral fellowship training in metabolism at the Washington University School of Medicine in St. Louis in Missouri. A board-certified endocrinologist, Dr. Dagogo-Jack has been elected to the Association of American Physicians and is the 2015 recipient of the Banting Medal for Leadership from the ADA. The ADA and Diabetes Care thank Dr. Dagogo-Jack for his outstanding leadership and service to the Association. PMID:26696655

  1. Northern Eurasia Future Initiative: Facing the Challenges of Global Change in the 21st century

    NASA Astrophysics Data System (ADS)

    Groisman, Pavel; Gutman, Garik; Gulev, Sergey; Maksyutov, Shamil; Qi, Jiaguo

    2016-04-01

    During the past 12 years, the Northern Eurasia Earth Science Partnership Initiative (NEESPI) - an interdisciplinary program of internationally-supported Earth systems and science research - has addressed large-scale and long-term manifestations of climate and environmental changes over Northern Eurasia and their impact on the Global Earth system. With more than 1500 peer-reviewed journal publications and 40 books to its credit, NEESPI's activities resulted in significant scientific outreach. This created a new research realm through self-organization of NEESPI scientists in a broad research network, accumulation of knowledge while developing new tools (observations, models, and collaborative networks) and producing new, exciting results that can be applied to directly support decision-making for societal needs. This realm was summed up at the Synthesis NEESPI Workshop in Prague, Czech Republic (April 9-12, 2015) where it was decided to shift gradually the foci of regional studies in Northern Eurasia towards applications with the following major Science Question: " What dynamic and interactive change(s) will affect societal well-being, activities, and health, and what might be the mitigation and adaptation strategies that could support sustainable development and decision-making activities in Northern Eurasia?". To answer this question requires a stronger socio-economic component in the ongoing and future regional studies focused on sustainable societal development under changing climatic and environmental conditions, especially, under conditions when societal decision-making impacts and feeds back on the environment. This made the NEESPI studies closer to the ICSU research initiative "Future Earth". Accordingly, the NEESPI Research Team decided to reorganize in the nearest future NEESPI into "Northern Eurasia Future Initiative" (NEFI) and began development of its Programmatic White Paper (in preparation at the time of this abstract submission). The NEFI research

  2. Northern Eurasia Future Initiative: Facing the Challenges of Global Change in the 21st century

    NASA Astrophysics Data System (ADS)

    Groisman, P. Y.; Gulev, S.; Maksyutov, S. S.; Qi, J.

    2015-12-01

    During the past 10 years, the Northern Eurasia Earth Science Partnership Initiative (NEESPI) - an interdisciplinary program of internationally-supported Earth systems and science research - has addressed large-scale and long-term manifestations of climate and environmental changes over Northern Eurasia and their impact on the Global Earth system. With more than 1480 peer-reviewed journal publications and 40 books to its credit, NEESPI's activities resulted in significant scientific outreach. This created a new research realm through self-organization of NEESPI scientists in a broad research network, accumulation of knowledge while developing new tools (observations, models, and collaborative networks) and producing new, exciting results that can be applied to directly support decision-making for societal needs. This realm was summed up at the Synthesis NEESPI Workshop in Prague, Czech Republic (April 9-12, 2015) where it was decided to shift gradually the foci of regional studies in Northern Eurasia towards applications with the following major Science Question: " What dynamic and interactive change(s) will affect societal well-being, activities, and health, and what might be the mitigation and adaptation strategies that could support sustainable development and decision-making activities in Northern Eurasia?". To answer this question requires a stronger socio-economic component in the ongoing and future regional studies focused on sustainable societal development under changing climatic and environmental conditions, especially, under conditions when societal decision-making impacts and feeds back on the environment. This made the NEESPI studies closer to the ICSU research initiative "Future Earth". Accordingly, the NEESPI Research Team decided to reorganize in the nearest future NEESPI into "Northern Eurasia Future Initiative" (NEFI) and began development of its Programmatic White Paper (in preparation at the time of this abstract submission). The NEFI research

  3. A Framework to Address Challenges in Communicating the Developmental Origins of Health and Disease.

    PubMed

    Winett, Liana; Wallack, Lawrence; Richardson, Dawn; Boone-Heinonen, Janne; Messer, Lynne

    2016-09-01

    Findings from the field of Developmental Origins of Health and Disease (DOHaD) suggest that some of the most pressing public health problems facing communities today may begin much earlier than previously understood. In particular, this body of work provides evidence that social, physical, chemical, environmental, and behavioral influences in early life play a significant role in establishing vulnerabilities for chronic disease later in life. Further, because this work points to the importance of adverse environmental exposures that cluster in population groups, it suggests that existing opportunities to intervene at a population level may need to refocus their efforts "upstream" to sufficiently combat the fundamental causes of disease. To translate these findings into improved public health, however, the distance between scientific discovery and population application will need to be bridged by conversations across a breadth of disciplines and social roles. And importantly, those involved will likely begin without a shared vocabulary or conceptual starting point. The purpose of this paper is to support and inform the translation of DOHaD findings from the bench to population-level health promotion and disease prevention, by: (1) discussing the unique communication challenges inherent to translation of DOHaD for broad audiences, (2) introducing the First-hit/Second-hit Framework with an epidemiologic planning matrix as a model for conceptualizing and structuring communication around DOHaD, and (3) discussing the ways in which patterns of communicating DOHaD findings can expand the range of solutions considered and encourage discussion of population-level solutions in relation to one another, rather than in isolation. PMID:27449924

  4. How can present and future satellite missions support scientific studies that address ocean acidification?

    USGS Publications Warehouse

    Salisbury, Joseph; Vandemark, Douglas; Jonsson, Bror; Balch, William; Chakraborty, Sumit; Lohrenz, Steven; Chapron, Bertrand; Hales, Burke; Mannino, Antonio; Mathis, Jeremy T.; Reul, Nicolas; Signorini, Sergio; Wanninkhof, Rik; Yates, Kimberly K.

    2016-01-01

    Space-based observations offer unique capabilities for studying spatial and temporal dynamics of the upper ocean inorganic carbon cycle and, in turn, supporting research tied to ocean acidification (OA). Satellite sensors measuring sea surface temperature, color, salinity, wind, waves, currents, and sea level enable a fuller understanding of a range of physical, chemical, and biological phenomena that drive regional OA dynamics as well as the potentially varied impacts of carbon cycle change on a broad range of ecosystems. Here, we update and expand on previous work that addresses the benefits of space-based assets for OA and carbonate system studies. Carbonate chemistry and the key processes controlling surface ocean OA variability are reviewed. Synthesis of present satellite data streams and their utility in this arena are discussed, as are opportunities on the horizon for using new satellite sensors with increased spectral, temporal, and/or spatial resolution. We outline applications that include the ability to track the biochemically dynamic nature of water masses, to map coral reefs at higher resolution, to discern functional phytoplankton groups and their relationships to acid perturbations, and to track processes that contribute to acid variation near the land-ocean interface.

  5. Measurement in Service Businesses: Challenges and Future Directions

    NASA Astrophysics Data System (ADS)

    Tyagi, Rajesh Kumar

    This chapter presents challenges faced by service businesses while implementing a measurement system. A review of existing frameworks is presented and a new framework, the Service Scorecard, is introduced. The Service Scorecard is an adaptation of the Six Sigma Business Scorecard for the service sector. The framework has also been influenced by existing frameworks such as the Malcom Baldrige award criteria, the Balanced Scorecard, the European Quality award and the Service Profit Chain model. The seven elements of the Service Scorecard are Growth, Leadership, Acceleration, Collaboration, Innovation, Execution, and Retention. The examples of measurement systems are presented with concrete real-world case examples. Final thoughts and the challenges faced are also presented.

  6. The Future of Education Research Publishing: Challenges and Responses

    ERIC Educational Resources Information Center

    Post, David

    2014-01-01

    This special issue of "Education Policy Analysis Archives" addresses scholarly production and publishing (the two are intimately related) in the field of education. Worldwide scholars are facing similar global pressures for "excellence," where the personal and institutional production of relevant scholarship is being compared…

  7. Constructing Pragmatic Socioeconomic Status Assessment Tools to Address Health Equality Challenges

    PubMed Central

    Tajik, Parvin; Majdzadeh, Reza

    2014-01-01

    Background: A key challenge for equality evaluation and monitoring, mainly in developing countries, is assessing socioeconomic status (SES) of individuals. This difficulty along with low technical competency, have resulted in many health information collected in these countries which are devoid of suitable SES indices. However, simplifying data collection requirements for estimating economic parameters seems to guarantee their wide adoption by survey and health information system (HIS) designers, resulting in immediate production of equity-oriented policy-relevant information. The goal of this study is obtaining adequate number of variables, which their combination can provide a valid assessment of SES in Iranian population. Methods: The data source was Living Standards Measurement Study of Iran (2006). Data of 27,000 households on the ownership of 33 household assets was used for this analysis. Households of this study were divided into 5 groups in terms of SES status using principle component analysis. Then selection was made among the 33 variables so that a combination with minimum necessary number for obtaining SES status is reached. Agreement of the new combination (including minimum number of variables) with full variable combination (including all 33 variables) was assessed using weighted kappa. Results: A minimum set of six variables including having kitchen, bathroom, vacuum cleaner, washing machine, freezer and personal computer could successfully discriminate SES of the population. Comparing this 6 item-index with the whole 33 item-index revealed that 65% of households were in the same quintiles, with a weighted kappa statistics of 0.76. For households in different quintiles, movement was generally limited to one quintile, with just 2% of households moving two or more quintiles. Conclusions: The proposed simple index is completely applicable in current Iran's society. It can be used in different survey and studies. The development is quite simple and can

  8. Regional initiatives to address the challenges of tuberculosis in children: perspectives from the Asia-Pacific region.

    PubMed

    Graham, Stephen M; Grzemska, Malgorzata; Brands, Annemieke; Nguyen, Huong; Amini, James; Triasih, Rina; Talukder, Khurshid; Ahmed, Shakil; Amanullah, Farhana; Kumar, Blessina; Tufail, Pervaiz; Detjen, Anne; Marais, Ben; Hennig, Cornelia; Islam, Tauhid

    2015-03-01

    Increasing attention is being given to the challenges of management and prevention of tuberculosis in children and adolescents. There have been a number of recent important milestones achieved at the global level to address this previously neglected disease. There is now a need to increase activities and build partnerships at the regional and national levels in order to address the wide policy-practice gaps for implementation, and to take the key steps outlined in the Roadmap for Child Tuberculosis published in 2013. In this article, we provide the rationale and suggest strategies illustrated with examples to improve diagnosis, management, outcomes and prevention for children with tuberculosis in the Asia-Pacific region, with an emphasis on the need for greatly improved recording and reporting. Effective collaboration with community engagement between the child health sector, the National Tuberculosis control Programmes, community-based services and the communities themselves are essential. PMID:25809775

  9. Mentally ill mothers who have killed: three cases addressing the issue of future parenting capability.

    PubMed

    Jacobsen, T; Miller, L J

    1998-05-01

    Many parents with severe and chronic mental illness lose custody of their children due to child abuse or neglect. These children may linger in foster care for long periods of time until decisions about custody are made. Recent proposals to shorten the time that children remain in the foster care system include the use of categories of abuse to guide decisions about custody. One proposal has been to "fast-track" cases involving parents with long-standing mental disorders by automatically terminating parental rights. This approach assumes that a severe and chronic mental disorder is incompatible with safe parenting. This report describes three cases of mentally ill mothers who lost custody of their children after they killed someone. The mothers were nonetheless found to be at low risk for future child maltreatment and violence according to evaluation with two current methodologies, Parenting Risk Assessment and Risk of Violence Assessment. The cases question the assumption that mental illness is incompatible with safe parenting and underscore the fact that evaluation of the parenting competency of mentally ill parents is rarely clear-cut. PMID:9603571

  10. What the Future Holds: Pressures, Challenges and Opportunities.

    ERIC Educational Resources Information Center

    Henchey, Norman

    1981-01-01

    Discusses pressures on education in the 1980s: declining enrollments, school criticism, increasing government control, demands for parent participation, competition for public resources, rising energy costs, growing media impact, climate of uncertainty and turbulence. Describes roles administrators can utilize in meeting these challenges:…

  11. Terrestrial Models and Global Change: Challenges for the Future

    NASA Technical Reports Server (NTRS)

    Hurtt, George C.; Moorcroft, Paul R.; Pacala, Stephen W.; Levin, Simon A.

    1998-01-01

    A wide variety of models have illustrated the potential importance of terrestrial biological feedbacks on climate and climate change, yet our ability to make precise predictions is severely limited, due to a high degree of uncertainty. In this paper, after briefly reviewing current models, we present challenges for new terrestrial models and introduce a simple mechanistic approach that may complement existing approaches.

  12. Soil science in Mexico: history, challenges, and future

    Technology Transfer Automated Retrieval System (TEKTRAN)

    There is a lack of information on the history of soil science in developing countries, such as Mexico. Scientists, farmers, and government agencies can use this type of information to identify the benefits, current state of understanding, and recognize the challenges associated with managing soil r...

  13. The Future of Management Education in Australia: Challenges and Innovations

    ERIC Educational Resources Information Center

    Hall, Richard; Agarwal, Renu; Green, Roy

    2013-01-01

    Purpose -- The purpose of this paper is to undertake a survey of the external and internal forces changing the nature of business schools and business education. It aims to investigate how management education responds to increasing productivity, innovation and capability challenges, examine how MBA programs currently meet these demands, and how…

  14. Future opportunities and challenges in remote sensing of drought

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Drought is a common feature of climate throughout the world with a broad footprint of impacts influencing natural systems and many sectors of society. This natural hazard can further exacerbate many important challenges confronting society today, including food security, freshwater availability, an...

  15. Institutional Strain and Precarious Values in Meeting Future Nuclear Challenges

    SciTech Connect

    Bruce Matthews; Todd R. LaPorte

    1998-11-01

    This paper explores the implications of moderately expanding plutonium "pit" production capability within the strongly R&D culture of Los Alamos National Laboratory, especially in terms of the lab's current capacity or "fitness for the future" in which institutional stewardship of the nation's nuclear deterrent capability becomes a primary objective. The institutional properties needed to assure "future fitness" includes the organizational requisites highly reliable operations and sustained institutional constancy in a manner that evokes deep public trust and confidence. Estimates are made of the degree to which the key Division and most relevant Program office in this evolution already exhibits them.

  16. New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences

    PubMed Central

    Hood, Leroy E.; Omenn, Gilbert S.; Moritz, Robert L.; Aebersold, Ruedi; Yamamoto, Keith R.; Amos, Michael; Hunter-Cevera, Jennie; Locascio, Laurie

    2014-01-01

    This White Paper sets out a Life Sciences Grand Challenge for Proteomics Technologies to enhance our understanding of complex biological systems, link genomes with phenotypes, and bring broad benefits to the biosciences and the US economy. The paper is based on a workshop hosted by the National Institute of Standards and Technology (NIST) in Gaithersburg, MD, 14–15 February 2011, with participants from many federal R&D agencies and research communities, under the aegis of the US National Science and Technology Council (NSTC). Opportunities are identified for a coordinated R&D effort to achieve major technology-based goals and address societal challenges in health, agriculture, nutrition, energy, environment, national security, and economic development. PMID:22807061

  17. Addressing the next challenges: A summary of the 22nd international symposium on hepatitis C virus and related viruses.

    PubMed

    Baumert, Thomas F; Schuster, Catherine; Cosset, François-Loïc; Dubuisson, Jean; Hofmann, Maike; Tautz, Norbert; Zeisel, Mirjam B; Thimme, Robert

    2016-04-01

    Following the discovery of the hepatitis C virus (HCV) more than 25years ago the field has succeeded to develop methods that have changed the safety of blood products, understand the molecular virology, epidemiology and clinical disease of HCV, and identify specific targets for the development of direct-acting antivirals for HCV cure. Nevertheless, major clinical and scientific challenges remain: therapy is still only available to a fraction of infected patients worldwide and many patients remain undiagnosed and/or live in countries where therapy is unattainable. An urgently needed HCV vaccine to eradicate infection remains still elusive. Scientifically, major questions remain regarding the life cycle, pathogenesis and mechanisms of viral clearance and persistence. Addressing these challenges, this meeting report reviews key findings of the 22nd International Symposium on Hepatitis C Virus and Related Viruses in Strasbourg, France from October 9 to 13, 2015. PMID:26780288

  18. Next biotech plants: new traits, crops, developers and technologies for addressing global challenges.

    PubMed

    Ricroch, Agnès E; Hénard-Damave, Marie-Cécile

    2016-08-01

    Most of the genetically modified (GM) plants currently commercialized encompass a handful of crop species (soybean, corn, cotton and canola) with agronomic characters (traits) directed against some biotic stresses (pest resistance, herbicide tolerance or both) and created by multinational companies. The same crops with agronomic traits already on the market today will continue to be commercialized, but there will be also a wider range of species with combined traits. The timeframe anticipated for market release of the next biotech plants will not only depend on science progress in research and development (R&D) in laboratories and fields, but also primarily on how demanding regulatory requirements are in countries where marketing approvals are pending. Regulatory constraints, including environmental and health impact assessments, have increased significantly in the past decades, delaying approvals and increasing their costs. This has sometimes discouraged public research entities and small and medium size plant breeding companies from using biotechnology and given preference to other technologies, not as stringently regulated. Nevertheless, R&D programs are flourishing in developing countries, boosted by the necessity to meet the global challenges that are food security of a booming world population while mitigating climate change impacts. Biotechnology is an instrument at the service of these imperatives and a wide variety of plants are currently tested for their high yield despite biotic and abiotic stresses. Many plants with higher water or nitrogen use efficiency, tolerant to cold, salinity or water submergence are being developed. Food security is not only a question of quantity but also of quality of agricultural and food products, to be available and accessible for the ones who need it the most. Many biotech plants (especially staple food) are therefore being developed with nutritional traits, such as biofortification in vitamins and metals. The main

  19. A framework for modeling anthropogenic impacts on waterbird habitats: addressing future uncertainty in conservation planning

    USGS Publications Warehouse

    Matchett, Elliott L.; Fleskes, Joseph P.; Young, Charles A.; Purkey, David R.

    2015-01-01

    The amount and quality of natural resources available for terrestrial and aquatic wildlife habitats are expected to decrease throughout the world in areas that are intensively managed for urban and agricultural uses. Changes in climate and management of increasingly limited water supplies may further impact water resources essential for sustaining habitats. In this report, we document adapting a Water Evaluation and Planning (WEAP) system model for the Central Valley of California. We demonstrate using this adapted model (WEAP-CVwh) to evaluate impacts produced from plausible future scenarios on agricultural and wetland habitats used by waterbirds and other wildlife. Processed output from WEAP-CVwh indicated varying levels of impact caused by projected climate, urbanization, and water supply management in scenarios used to exemplify this approach. Among scenarios, the NCAR-CCSM3 A2 climate projection had a greater impact than the CNRM-CM3 B1 climate projection, whereas expansive urbanization had a greater impact than strategic urbanization, on annual availability of waterbird habitat. Scenarios including extensive rice-idling or substantial instream flow requirements on important water supply sources produced large impacts on annual availability of waterbird habitat. In the year corresponding with the greatest habitat reduction for each scenario, the scenario including instream flow requirements resulted in the greatest decrease in habitats throughout all months of the wintering period relative to other scenarios. This approach provides a new and useful tool for habitat conservation planning in the Central Valley and a model to guide similar research investigations aiming to inform conservation, management, and restoration of important wildlife habitats.

  20. Past successes and future challenges: Improving the urban environment

    SciTech Connect

    Gade, M.

    1994-12-31

    The author discusses issues related to the Chicago urban environment from her perspective in the Illinois Environmental Protection Agency. Understanding of the ozone air pollution problem in the Chicago area has undergone significant changes in the past three years, and there is still more to be understood about the complex factors which contribute to ozone pollution over urban areas such as Chicago. Ability to address these problems to present clean air standards is not in hand at present. The author asserts that information, and the ability of governmental agencies to ingest and respond to that information in a timely manner is a key to improvement of the environment in urban areas in reasonable time spans. In addition cost and price information on environmental control and protection needs to be more clearly presented to the people so they can understand the difficult choices which must be made in addressing these environmental problems.

  1. Brief psychodynamic psychotherapies. Past, present, and future challenges

    PubMed Central

    Kay, Jerald

    1997-01-01

    The future educational and research needs of brief psychodynamic psychotherapy are discussed. Specific shortcomings of current education and training in brief dynamic therapies are elucidated. Many of these are relevant to psychotherapy instruction in graduate medical education in nondynamic treatments as well. Educational and technological recommendations are suggested to remedy these shortcomings. PMID:9292447

  2. The Future of Global Change: A Challenge to Librarians.

    ERIC Educational Resources Information Center

    Eisenbeis, Kathleen M.

    1995-01-01

    Discusses the evolving Global Change Data and Information System (GCDIS) and the need for librarians and information scientists to become part of the user-feedback process to make the GCDIS effective, both now and in the future when public access through the Internet will be possible. (LRW)

  3. Experiential Learning in Retrospect: A Future Organizational Challenge?

    ERIC Educational Resources Information Center

    Olsson, Annika; Bjoorn, Urban; Jonson, Gunilla

    2008-01-01

    Purpose: The purpose of this paper is to describe a retrospective reflection over unconscious, emergent learning among employees of an organization and to suggest how to capture these moments of experiential learning for future organizational learning. Design/methodology/approach: Action research in organizations is undertaken in interaction with…

  4. Future Directions, Challenges and Opportunities in Nuclear Energy

    SciTech Connect

    Andy Klein; Jack Lance

    2006-07-01

    The renaissance of nuclear energy for electricity and hydrogen production and process heat for other potential applications is moving ahead rapidly. Both near- and far-term roles are envisioned for this important energy technology, and each of these roles will have its own particular technical challenges and opportunities. Numerous power producers world-wide are actively considering the construction of new nuclear power plants for the production of electricity in the near-term. The U.S. Department of Energy has announced plans to develop both the next generation of nuclear power plants and the technology necessary to recycle used nuclear fuel. These exciting technologies will bring novel challenges to their developers and designers as they push the knowledge base in materials utilization, high temperatures and pressures, extended operating cycles, and extreme operating environments. Development of the techniques and methods to interrogate, understand, manage and control these devices will be crucial to enabling the full extension of these technologies.

  5. Awake craniotomy: A qualitative review and future challenges

    PubMed Central

    Ghazanwy, Mahmood; Chakrabarti, Rajkalyan; Tewari, Anurag; Sinha, Ashish

    2014-01-01

    Neurosurgery in awake patients incorporates newer technologies that require the anesthesiologists to update their skills and evolve their methodologies. They need effective communication skills and knowledge of selecting the right anesthetic drugs to ensure adequate analgesia, akinesia, along with patient satisfaction with the anesthetic conduct throughout the procedure. The challenge of providing adequate anesthetic care to an awake patient for intracranial surgery requires more than routine vigilance about anesthetic management. PMID:25422613

  6. Future of the Book? Challenge of the Digital World

    ERIC Educational Resources Information Center

    Pledger, Pat

    2010-01-01

    In the last ten years there has been much speculation about the role of e-books and e-book readers. This paper will look at the impact of e-book readers on publishing and reading, the types of e-book readers, their advantages and disadvantages. Some ideas for future e-books and e-book readers and their use in the library and classroom will be…

  7. Future challenges and DOE/NNSA-JAEA cooperation for the development of advanced safeguards

    SciTech Connect

    Stevens, Rebecca S; Mc Clelland - Kerr, John; Senzaki, Masao; Hori, Masato

    2009-01-01

    The United States Department of Energy/National Nuclear Security Administration (DOE/NNSA) has been cooperating with Japan on nuclear safeguards for over thirty years. DOE/NNSA has collaborated with the Japan Atomic Energy Agency (JAEA) and its predecessors in addressing the need for innovative solutions to nuclear transparency and verification issues in one of the world's most advanced nuclear fuel cycle states. This collaboration includes over ninety activities that have involved nearly every facility in the JAEA complex and many national laboratories in the U.S. complex. The partnership has yielded new technologies and approaches that have benefited international safeguards not only in Japan, but around the world. The International Atomic Energy Agency uses a number of safeguards solutions developed under this collaboration to improve its inspection efforts in Japan and elsewhere. Japanese facilities serve as test beds for emerging safeguards technologies and are setting the trend for new nuclear energy and fuel cycle development worldwide. The collaboration continues to be an essential component of U.S. safeguards outreach and is integral to the DOE/NNSA's Next Generation Safeguards Initiative. In addition to fostering international safeguards development, the cooperation is an opportunity for U.S. scientists to work in facilities that have no analog in the United States, thus providing crucial real-life experience for and aiding development of the next generation of U.S. safeguards specialists. It is also an important element of promoting regional transparency thereby building confidence in the peaceful nature of nuclear programs in the region. The successes engendered by this partnership provide a strong basis for addressing future safeguards challenges, in Japan and elsewhere. This paper summarizes these challenges and the associated cooperative efforts that are either underway or anticipated.

  8. Challenges of the NGSS for Future Geoscience Education

    NASA Astrophysics Data System (ADS)

    Wysession, M. E.; Colson, M.; Duschl, R. A.; Lopez, R. E.; Messina, P.; Speranza, P.

    2013-12-01

    The new Next Generation Science Standards (NGSS), which spell out a set of K-12 performance expectations for life science, physical science, and Earth and space science (ESS), pose a variety of opportunities and challenges for geoscience education. Among the changes recommended by the NGSS include establishing ESS on an equal footing with both life science and physical sciences, at the full K-12 level. This represents a departure from the traditional high school curriculum in most states. In addition, ESS is presented as a complex, integrated, interdisciplinary, quantitative Earth Systems-oriented set of sciences that includes complex and politically controversial topics such as climate change and human impacts. The geoscience communities will need to mobilize in order to assist and aid in the full implementation of ESS aspects of the NGSS in as many states as possible. In this context, the NGSS highlight Earth and space science to an unprecedented degree. If the NGSS are implemented in an optimal manner, a year of ESS will be taught in both middle and high school. In addition, because of the complexity and interconnectedness of the ESS content (with material such as climate change and human sustainability), it is recommended (Appendix K of the NGSS release) that much of it be taught following physics, chemistry, and biology. However, there are considerable challenges to a full adoption of the NGSS. A sufficient work force of high school geoscientists qualified in modern Earth Systems Science does not exist and will need to be trained. Many colleges do not credit high school geoscience as a lab science with respect to college admission. The NGSS demand curricular practices that include analyzing and interpreting real geoscience data, and these curricular modules do not yet exist. However, a concerted effort on the part of geoscience research and education organizations can help resolve these challenges.

  9. Water challenges of the future; how scientific understanding can help

    NASA Astrophysics Data System (ADS)

    Young, G.

    2012-04-01

    Demands for water resources are diverse and are increasing as human populations grow and become more concentrated in urban areas and as economies develop. Water is essential for many uses including the basic human needs of food and the maintenance of good health, for many industries and the creation of electrical energy and as vital for the sustenance of the natural ecosystems on which all life is dependent. At the same time threats from water - floods, droughts - are increasing with these extreme events becoming more common and more intense in many regions of the world and as more people locate in flood- and drought-prone regions. In general, the challenges for water managers are thus becoming greater; managers not only are having to make increasingly difficult decisions regarding allocation of water resources between competing uses as demand outstrips supply, but they also have to take measures to protect societies from the ravages of extreme events. The intensity of the challenges facing water managers is not uniform throughout the world - many nations in the less developed world experiencing far greater problems than most highly developed nations - but the trend towards greater challenges is clear. Decision-makers, whether at the international, national, provincial or local level benefit from reliable information on water resources. They need information on the availability in quantity and quality of water from a variety of sources - surface waters, aquifers or from artificial sources such as re-cycling of wastewater and desalination techniques. Managers also need reliable predictions on water availability for the various uses to which water is put - such predictions are needed on time scales from weeks to decades to inform decision-making. Predictions are also needed on the probabilities of occurrence of extreme events. Thus hydrological scientists developing predictive models and working within a fast-changing world have much to contribute to the needs of

  10. Review: New Vaccine Against Tuberculosis: Current Developments and Future Challenges

    NASA Astrophysics Data System (ADS)

    Liu, Jun

    2009-04-01

    Tuberculosis (TB) continues to be a global health threat. BCG was developed as an attenuated live vaccine for tuberculosis control nearly a century ago. Despite being the most widely used vaccine in human history, BCG is not an ideal vaccine and has two major limitations: its poor efficacy against adult pulmonary TB and its disconcerting safety in immunocompromised individuals. A safer and more effective TB vaccine is urgently needed. This review article discusses current strategies to develop the next generation of TB vaccines to replace BCG. While some progresses have been made in the past decade, significant challenges lie ahead.

  11. The quantified patient of the future: Opportunities and challenges.

    PubMed

    Majmudar, Maulik D; Colucci, Lina Avancini; Landman, Adam B

    2015-09-01

    The healthcare system is undergoing rapid transformation as national policies increase patient access, reward positive health outcomes, and push for an end to the current era of episodic care. Advances in health sensors are rapidly moving diagnostic and monitoring capabilities into consumer products, enabling new care models. Although hospitals and health care providers have been slow to embrace novel health technologies, such innovations may help meet mounting pressure to provide timely, high quality, and low-cost care to large populations. This leading edge perspective focuses on the quantified-self movement and highlights the opportunities and challenges for patients, providers, and researchers. PMID:26384227

  12. Current concepts and future challenges in facial transplantation.

    PubMed

    Lengelé, Benoît G

    2009-07-01

    Facial allotransplantation has become a surgical reality. The first successful segmental human face transplants have demonstrated that facial allografts are reliable, their rejection can be prevented by low-dose immunosuppression, and their neurologic recovery enables oral and expressive functions of the face to be restored. Clinical facts have shown that the risk-benefit balance is acceptable in the medium term, that at the neurocognitive level the allograft is reintegrated in the body scheme of the recipient, and that it does not engender a donor identity transfer. This article presents a classification of facial allografts and discusses the technical, immunologic, and ethical challenges that lie ahead. PMID:19505618

  13. Eleventh annual Warren K. Sinclair keynote address-science, radiation protection and NCRP: building on the past, looking to the future.

    PubMed

    Bushberg, Jerrold T

    2015-02-01

    The many reports and other authoritative documents developed and published by the National Council on Radiation Protection and Measurements (NCRP) have been of great service to the nation and the radiation protection community since its Congressional charter was signed into law 50 y ago. There will be a continuing need for NCRP to identify the principles upon which radiation protection is to be based and to provide guidance on best practices for the practical application of those principles for the many beneficial uses of radiation in society. The unique and invaluable resource that is NCRP is in large part due to the selfless dedication and numerous contributions of its Council and scientific committee members. The multidisciplinary composition of these leading experts and their collective input on complex questions provide a unique synergy that results in a comprehensive and well-balanced approach to addressing current and future radiation protection challenges. Subsequent articles in these proceedings covering a broad range of relevant topics will review sentinel accomplishments of the past as well as current work and future challenges that are in keeping with NCRP's mission to advance the science of radiation protection in the public interest. PMID:25551490

  14. Challenges for a Local Service Agency to Address Domestic Violence –A Case Study From Rural Indonesia

    PubMed Central

    Hayati, Elli Nur; Emmelin, Maria; Eriksson, Malin

    2014-01-01

    Since the launch of a Zero Tolerance Policy in Indonesia, several policies to address domestic violence have been enacted. The obligation of local governments to establish service units for women survivors of domestic violence is one of them. Since domestic violence is a sensitive and complex issue in Indonesia it is important to understand how governmentally regulated services function in practice. This case study aimed to explore challenges faced by a local service agency in managing service provision for women survivors of domestic violence in rural Indonesia. Data from one focus group discussion (12 participants), four individual interviews, six short narratives, two days of participant observation, as well as archive reviews were collected. All data were analyzed using Grounded Theory Situational Analysis. The major challenge faced by the local agency was the low priority that was given them by the local authorities, mirrored also in low involvement by the assigned volunteers in the daily service. The study also identified a gap between the socio-cultural arena and the law & policy arena that needs to be bridged to avoid that the two arenas address domestic violence in a contradictory way. Budget allocation to support the sustainability of the daily routines of service agencies has to be given priority. There is also a need for careful considerations regarding the composition of personnel involved within daily management of service agencies addressing domestic violence. To bridge the gap between the legal systems and traditional cultural values, culturally adjusted alternative justice systems could be developed to increase women’s access to legal support. PMID:25363105

  15. Rheology of Rings: Current Status and Future Challenges

    NASA Astrophysics Data System (ADS)

    McKenna, Gregory

    Understanding the dynamics of circular or ring-like polymers has been a subject of investigation since the 1980s and is one which remains an area that is not fully understood. Part of the reason for this is the difficulty of making synthetic rings of sufficient size to establish the nature of the entanglement dynamics, if entanglements even exist in these materials. Furthermore, there is now strong evidence that small amounts of linear impurities can impact the dynamics. Hence, one of the major challenges to our understanding of ring dynamics is to make large molecular weight rings of sufficient purity that the dynamics of the rings themselves can be determined. In the present work the current state of understanding of the dynamics of rings is outlined and current work from our group of collaborators to make extremely large circular polymers using Echeverria Coli as a route to make pure rings (circular DNA) in sufficient quantity and size to determine the dynamics of these materials will be shown. First results of ring dynamics in dilute solution are presented and new results on concentrated and entangled solutions will be discussed. Remaining challenges will be elucidated. Partially supported by the John R. Bradford Endowment and the Paul Whitfield Horn Professorship at Texas Tech University.

  16. Future Challenges and Opportunities in Online Prescription Drug Promotion Research

    PubMed Central

    Southwell, Brian G.; Rupert, Douglas J.

    2016-01-01

    Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to conventional broadcast and print advertising and ways in which it differs. We also highlight five key areas for future research: branded drug website influence on consumer knowledge and behavior, interactive features on branded drug websites, mobile viewing of branded websites and mobile advertisements, online promotion and non-US audiences, and social media and medication decisions. PMID:26927597

  17. Challenges and Future Opportunities in Our Nation's Space Program

    NASA Technical Reports Server (NTRS)

    Clements, Greg

    2011-01-01

    For the first time in decades, there is a significant amount of change in our nation's space program. Along with change, there are opportunities, and NASA has begun a set of planning to be prepared for the future, emphasizing innovation and technology development, increased emphasis on collaboration, commercially-provided access to space, and the need for reinvention. This discussion will briefly give an overview of NASA, showcase some of the diverse activities that are part of our nation' fs space program, identify some of the new changes envisioned to NASA's mission, and how our space program can continue to inspire the nation during changing times.

  18. Clinical Research with Transcranial Direct Current Stimulation (tDCS): Challenges and Future Directions

    PubMed Central

    Brunoni, Andre Russowsky; Nitsche, Michael A.; Bolognini, Nadia; Bikson, Marom; Wagner, Tim; Merabet, Lotfi; Edwards, Dylan J.; Valero-Cabre, Antoni; Rotenberg, Alexander; Pascual-Leone, Alvaro; Ferrucci, Roberta; Priori, Alberto; Boggio, Paulo; Fregni, Felipe

    2011-01-01

    Background Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers low-intensity, direct current to cortical areas facilitating or inhibiting spontaneous neuronal activity. In the past ten years, tDCS physiological mechanisms of action have been intensively investigated giving support for the investigation of its applications in clinical neuropsychiatry and rehabilitation. However, new methodological, ethical, and regulatory issues emerge when translating the findings of preclinical and phase I studies into phase II and III clinical studies. The aim of this comprehensive review is to discuss the key challenges of this process and possible methods to address them. Methods We convened a workgroup of researchers in the field to review, discuss and provide updates and key challenges of neuromodulation use for clinical research. Main Findings/Discussion We reviewed several basic and clinical studies in the field and identified potential limitations, taking into account the particularities of the technique. We review and discuss the findings into four topics: (i) mechanisms of action of tDCS, parameters of use and computer-based human brain modeling investigating electric current fields and magnitude induced by tDCS; (ii) methodological aspects related to the clinical research of tDCS as divided according to study phase (i.e., preclinical, phase I, phase II and phase III studies); (iii) ethical and regulatory concerns; (iv) future directions regarding novel approaches, novel devices, and future studies involving tDCS. Finally, we propose some alternative methods to facilitate clinical research on tDCS. PMID:22037126

  19. Credentialing in radiology: Current practice and future challenges

    PubMed Central

    Youssef, Adam; McCoubrie, Paul

    2016-01-01

    Radiology has changed significantly in recent years. The volume of work has increased dramatically as has its complexity. Future radiologists need an adequate training and expertise in conventional practice as well as new techniques. This comes at a time when other stakeholders outside of radiology are voicing their own concerns. The rightly justified increasing focus on patient safety has placed even more emphasis on the demonstration of competent practice by all health care professionals. Credentialing has been put forward as a way to ensure a doctor is competent in specific areas. Credentialing may be an alien concept to many radiology trainees but moves are afoot in the United Kingdom to bring it to the forefront of its postgraduate medical training. Credentialing began in 20th century North America where it was linked to the process of privileging. It subsequently garnered a strong patient safety focus and has become a part of the international healthcare agenda. Not everyone agrees with credentialing, it has many criticisms including the risk of speciality “turf wars” and the stifling of medical excellence to name just a couple. Is credentialing in radiology here to stay or will it pass by quietly? This paper reviews the global credentialing movement and discusses how this may impact on future radiology training, using the United Kingdom as its case example. PMID:27247716

  20. Credentialing in radiology: Current practice and future challenges.

    PubMed

    Youssef, Adam; McCoubrie, Paul

    2016-05-28

    Radiology has changed significantly in recent years. The volume of work has increased dramatically as has its complexity. Future radiologists need an adequate training and expertise in conventional practice as well as new techniques. This comes at a time when other stakeholders outside of radiology are voicing their own concerns. The rightly justified increasing focus on patient safety has placed even more emphasis on the demonstration of competent practice by all health care professionals. Credentialing has been put forward as a way to ensure a doctor is competent in specific areas. Credentialing may be an alien concept to many radiology trainees but moves are afoot in the United Kingdom to bring it to the forefront of its postgraduate medical training. Credentialing began in 20(th) century North America where it was linked to the process of privileging. It subsequently garnered a strong patient safety focus and has become a part of the international healthcare agenda. Not everyone agrees with credentialing, it has many criticisms including the risk of speciality "turf wars" and the stifling of medical excellence to name just a couple. Is credentialing in radiology here to stay or will it pass by quietly? This paper reviews the global credentialing movement and discusses how this may impact on future radiology training, using the United Kingdom as its case example. PMID:27247716

  1. Proteomics of Staphylococcus aureus--current state and future challenges.

    PubMed

    Hecker, Michael; Engelmann, Susanne; Cordwell, Stuart J

    2003-04-01

    This paper presents a short review of the proteome of Staphylococcus aureus, a gram-positive human pathogen of increasing importance for human health as a result of the increasing antibiotic resistance. A proteome reference map is shown which can be used for future studies and is followed by a demonstration of how proteomics could be applied to obtain new information on S. aureus physiology. The proteomic approach can provide new data on the regulation of metabolism as well as of the stress or starvation responses. Proteomic signatures encompassing specific stress or starvation proteins are excellent tools to predict the physiological state of a cell population. Furthermore proteomics is very useful for analysing the size and function of known and unknown regulons and will open a new dimension in the comprehensive understanding of regulatory networks in pathogenicity. Finally, some fields of application of S. aureus proteomics are discussed, including proteomics and strain evaluation, the role of proteomics for analysis of antibiotic resistance or for discovering new targets and diagnostics tools. The review also shows that the post-genome era of S. aureus which began in 2001 with the publication of the genome sequence is still in a preliminary stage, however, the consequent application of proteomics in combination with DNA array techniques and supported by bioinformatics will provide a comprehensive picture on cell physiology and pathogenicity in the near future. PMID:12659740

  2. Ionospheric Electric Field and Energetic Particles; Past Successes, Future Challenges

    NASA Astrophysics Data System (ADS)

    Rodger, A. S.

    2005-12-01

    The International Geophysical Year (1957-58) saw a step-increase in the number of ionospheric observations in both polar regions and the establishment of the World Data Centres allowing free exchange of information. Exploitation of these data from such networks of observatories, combined with the early satellite measurements, demonstrated that electric fields and energetic particles driven by solar wind-magnetosphere interactions are of paramount importance in determining the structure and dynamics of the high-latitude ionosphere. Over the next five decades, much greater understanding of the interactions of the solar wind-magnetosphere-ionosphere system has been achieved. Many features and phenomena can now be predicted with a good degree of accuracy, given the initial solar wind conditions. A few scientific milestones will be presented, many of which have resulted from technical innovations, such as coherent and incoherent radars, and optical imaging. The International Heliophysical and Polar Years offer an excellent opportunity to address the outstanding issues of geospace research. Specific examples will be described. These include the spatial and temporal deposition of energy into the ionosphere and thermosphere by particles and electric fields both on the day side and nightside as a result of reconnection and substorms, and the interaction of micro-scale processes on the meso and macro-scale structure of the coupled system. Such complex topics can now be addressed for the first time with the enhanced capabilities of the ground-based networks of observatories, well complemented by remote sensing from satellites. The outcome will be much improved understanding of the closely-coupled SW-M-I-T system and hence better predictions both for space weather and Sun-Earth connections.

  3. Addressing the Creationist Challenge.

    ERIC Educational Resources Information Center

    Seaford, H. Wade, Jr.

    1990-01-01

    Describes a method of contrasting "scientific creationism" and evolution, or pseudo-science and science, that was utilized in a freshman seminar at Dickinson College. Discusses how the seminar format fostered analytical thinking, research, and writing skills. Presents responses given by creationist students after the course. (JS)

  4. Technical challenges for the future of high energy lasers

    NASA Astrophysics Data System (ADS)

    LaFortune, K. N.; Hurd, R. L.; Fochs, S. N.; Rotter, M. D.; Pax, P. H.; Combs, R. L.; Olivier, S. S.; Brase, J. M.; Yamamoto, R. M.

    2007-02-01

    The Solid-State, Heat-Capacity Laser (SSHCL) program at Lawrence Livermore National Laboratory is a multi-generation laser development effort scalable to the megawatt power levels with current performance approaching 100 kilowatts. This program is one of many designed to harness the power of lasers for use as directed energy weapons. There are many hurdles common to all of these programs that must be overcome to make the technology viable. There will be a in-depth discussion of the general issues facing state-of-the-art high energy lasers and paths to their resolution. Despite the relative simplicity of the SSHCL design, many challenges have been uncovered in the implementation of this particular system. An overview of these and their resolution are discussed. The overall system design of the SSHCL, technological strengths and weaknesses, and most recent experimental results will be presented.

  5. Key challenges in future Li-battery research.

    PubMed

    Tarascon, J-M

    2010-07-28

    Batteries are a major technological challenge in this new century as they are a key method to make more efficient use of energy. Although today's Li-ion technology has conquered the portable electronic markets and is still improving, it falls short of meeting the demands dictated by the powering of both hybrid electric vehicles and electric vehicles or by the storage of renewable energies (wind, solar). There is room for optimism as long as we pursue paradigm shifts while keeping in mind the concept of materials sustainability. Some of these concepts, relying on new ways to prepare electrode materials via eco-efficient processes, on the use of organic rather than inorganic materials or new chemistries will be discussed. Achieving these concepts will require the inputs of multiple disciplines. PMID:20566508

  6. Recapitalizing EMSL: Meeting Future Science and Technology Challenges

    SciTech Connect

    Felmy, Andrew R.

    2008-07-01

    EMSL, located in Richland, Washington, is a national scientific user facility operated for the U.S. Department of Energy (DOE) by the Pacific Northwest National Laboratory. The vision that directed the development of EMSL as a problem-solving environment for environmental molecular science has led to significant scientific progress in many areas ranging from subsurface science to atmospheric sciences, and from biochemistry to catalysis. Our scientific staff and users are recognized nationally and internationally for their significant contributions to solving challenging scientific problems. We have explored new scientific frontiers and organized a vibrant and diverse user community in support of our mission as a national scientific user facility that provides integrated experimental and computational resources in the environmental molecular sciences. Users from around the world - from academia to industry and national laboratories to international research organizations - use the resources of EMSL because of the quality of science that we enable.

  7. Technical challenges for the future of high energy lasers

    SciTech Connect

    LaFortune, K N; Hurd, R L; Fochs, S N; Rotter, M D; Pax, P H; Combs, R L; Olivier, S S; Brase, J M; Yamamoto, R M

    2007-01-10

    The Solid-State, Heat-Capacity Laser (SSHCL) program at Lawrence Livermore National Laboratory is a multi-generation laser development effort scalable to the megawatt power levels with current performance approaching 100 kilowatts. This program is one of many designed to harness the power of lasers for use as directed energy weapons. There are many hurdles common to all of these programs that must be overcome to make the technology viable. There will be a in-depth discussion of the general issues facing state-of-the-art high energy lasers and paths to their resolution. Despite the relative simplicity of the SSHCL design, many challenges have been uncovered in the implementation of this particular system. An overview of these and their resolution are discussed. The overall system design of the SSHCL, technological strengths and weaknesses, and most recent experimental results will be presented.

  8. Research in mosquito control: current challenges for a brighter future.

    PubMed

    Benelli, Giovanni

    2015-08-01

    Mosquitoes (Diptera: Culicidae) are a key threat for millions of people worldwide, since they act as vectors for devastating pathogens and parasites. In this scenario, vector control is crucial. Mosquito larvae are usually targeted using organophosphates, insect growth regulators, and microbial agents. Indoor residual spraying and insecticide-treated bed nets are also employed. However, these chemicals have negative effects on human health and the environment and induce resistance in a number of vectors. Newer and safer tools have been recently implemented to enhance control of mosquitoes. Here, I focus on some crucial challenges about eco-friendly control of mosquito vectors, mainly the improvement of behavior-based control strategies (sterile insect technique ("SIT") and "boosted SIT") and plant-borne mosquitocidals, including green-synthesized nanoparticles. A number of hot areas that need further research and cooperation among parasitologists, entomologists, and behavioral ecologists are highlighted. PMID:26093499

  9. Successes, Challenges and Future Outlook of Multivariate Analysis In HEP

    NASA Astrophysics Data System (ADS)

    Voss, Helge

    2015-05-01

    Multivariate techniques using machine learning algorithms have become an integral part in many High Energy Physics data analyses. This article is intended to sketch how this development took place by pointing out a few analyses that pushed forward the exploitation of these powerful analysis techniques. This article does not focus on controversial issues like for example how systematic uncertainties can be dealt with when using such techniques, which have been widely discussed previously by other authors. The main purpose here is to point to the gain in physics reach of the physics experiments due to the adaptation of machine learning techniques and to the challenges the HEP community faces in the light a rapid development in the field of machine learning if we want to make successful use of these powerful selection and reconstruction techniques.

  10. Cell carriers for oncolytic viruses: current challenges and future directions.

    PubMed

    Roy, Dominic G; Bell, John C

    2013-01-01

    The optimal route for clinical delivery of oncolytic viruses is thought to be systemic intravenous injection; however, the immune system is armed with several highly efficient mechanisms to remove pathogens from the circulatory system. To overcome the challenges faced in trying to delivery oncolytic viruses specifically to tumors via the bloodstream, carrier cells have been investigated to determine their suitability as delivery vehicles for systemic administration of oncolytic viruses. Cell carriers protect viruses from neutralization, one of the most limiting aspects of oncolytic virus interaction with the immune system. Cell carriers can also possess inherent tumor tropism, thus directing the delivery of the virus more specifically to a tumor. With preclinical studies already demonstrating the success and feasibility of this approach with multiple oncolytic viruses, clinical evaluation of cell-mediated delivery of viruses is on the horizon. Meanwhile, ongoing preclinical studies are aimed at identifying new cellular vehicles for oncolytic viruses and improving current promising cell carrier platforms. PMID:27512657

  11. Future challenges in the elimination of bacterial meningitis.

    PubMed

    Bottomley, Matthew J; Serruto, Davide; Sáfadi, Marco Aurélio Palazzi; Klugman, Keith P

    2012-05-30

    Despite the widespread implementation of several effective vaccines over the past few decades, bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis and Group B Streptococcus (GBS) still results in unacceptably high levels of human mortality and morbidity. A residual disease burden due to bacterial meningitis is also apparent due to a number of persistent or emerging pathogens, including Mycobacterium tuberculosis, Escherichia coli, Staphylococcus aureus, Salmonella spp. and Streptococcus suis. Here, we review the current status of bacterial meningitis caused by these pathogens, highlighting how past and present vaccination programs have attempted to counter these pathogens. We discuss how improved pathogen surveillance, implementation of current vaccines, and development of novel vaccines may be expected to further reduce bacterial meningitis and related diseases in the future. PMID:22607903

  12. Technical and Observational Challenges for Future Time-Domain Surveys

    NASA Astrophysics Data System (ADS)

    Bloom, Joshua S.

    2012-04-01

    By the end of the last decade, robotic telescopes were established as effective alternatives to the traditional role of astronomer in planning, conducting and reducing time-domain observations. By the end of this decade, machines will play a much more central role in the discovery and classification of time-domain events observed by such robots. While this abstraction of humans away from the real-time loop (and the nightly slog of the nominal scientific process) is inevitable, just how we will get there as a community is uncertain. I discuss the importance of machine learning in astronomy today, and project where we might consider heading in the future. I will also touch on the role of people and organisations in shaping and maximising the scientific returns of the coming data deluge.

  13. Current and future challenges in space weather science

    NASA Astrophysics Data System (ADS)

    Zhukov, Andrei

    The main objective of the space weather science is to provide a scientific basis for reliable space weather forecasting. The importance of space weather forecasting is increasing as our society is becoming more and more dependent on advanced technologies that may be affected by adverse space weather conditions. Space weather forecasting is still a difficult task and requires specific observational inputs that are reviewed in this presentation, with an emphasis on solar and interplanetary weather. A list of key observations that are essential for real-time operational space weather forecasting is established. Further on, the use of observational data to produce reliable predictions requires development of empirical and statistical methods, as well as physical models. Scientific basis of space weather forecasting is briefly described. Several important problems are emphasized, and possible ways of improving our predictive capabilities are discussed, including possible novel space observations to be made in future.

  14. Stem Cells toward the Future: The Space Challenge.

    PubMed

    Bradamante, Silvia; Barenghi, Livia; Maier, Jeanette A M

    2014-01-01

    Astronauts experience weightlessness-induced bone loss due to an unbalanced process of bone remodeling that involves bone mesenchymal stem cells (bMSCs), as well as osteoblasts, osteocytes, and osteoclasts. The effects of microgravity on osteo-cells have been extensively studied, but it is only recently that consideration has been given to the role of bone MSCs. These live in adult bone marrow niches, are characterized by their self-renewal and multipotent differentiation capacities, and the published data indicate that they may lead to interesting returns in the biomedical/bioengineering fields. This review describes the published findings concerning bMSCs exposed to simulated/real microgravity, mainly concentrating on how mechanosignaling, mechanotransduction and oxygen influence their proliferation, senescence and differentiation. A comprehensive understanding of bMSC behavior in microgravity and their role in preventing bone loss will be essential for entering the future age of long-lasting, manned space exploration. PMID:25370198

  15. The Internet for neurosurgeons: current resources and future challenges.

    PubMed

    Hughes, Mark A; Brennan, Paul M

    2011-06-01

    Our professional and personal lives depend increasingly on access to information via the Internet. As an open access resource, the Internet is on the whole unbridled by censorship and can facilitate the rapid propagation of ideas and discoveries. At the same time, this liberty in sharing information, being unregulated and often free from external validation, can be oppressive; overloading the user and hindering effective decision-making. It can be difficult, if not impossible, to reliably ascertain the provenance of data and opinion. We must, therefore, discern what is useful, relevant, and above all reliable if we are to harness the Internet's potential to improve training, delivery of care, research, and provision of patient information. This article profiles the resources currently available to neurosurgeons, asks how we can sort the informational wheat from the chaff, and explores where future developments might further influence neurosurgical practice. PMID:21501057

  16. Opportunities and challenges for a sustainable energy future.

    PubMed

    Chu, Steven; Majumdar, Arun

    2012-08-16

    Access to clean, affordable and reliable energy has been a cornerstone of the world's increasing prosperity and economic growth since the beginning of the industrial revolution. Our use of energy in the twenty-first century must also be sustainable. Solar and water-based energy generation, and engineering of microbes to produce biofuels are a few examples of the alternatives. This Perspective puts these opportunities into a larger context by relating them to a number of aspects in the transportation and electricity generation sectors. It also provides a snapshot of the current energy landscape and discusses several research and development opportunities and pathways that could lead to a prosperous, sustainable and secure energy future for the world. PMID:22895334

  17. Future Challenges and Opportunities: Toward Culturally Responsible Training in School Psychology

    ERIC Educational Resources Information Center

    Lopez, Emilia C.; Bursztyn, Alberto M.

    2013-01-01

    This article argues that school psychology programs must prepare future school psychologists to address the needs of our increasingly diverse society. Providing training and field experiences that are grounded in multicultural practices, research, and advocacy will foster greater competence in addressing diverse schools', students', and families'…

  18. Future Opportunities and Challenges in Remote Sensing of Drought

    NASA Technical Reports Server (NTRS)

    Wardlow, Brian D.; Anderson, Martha C.; Sheffield, Justin; Doorn, Brad; Zhan, Xiwu; Rodell, Matt

    2011-01-01

    The value of satellite remote sensing for drought monitoring was first realized more than two decades ago with the application of Normalized Difference Index (NDVI) data from the Advanced Very High Resolution Radiometer (AVHRR) for assessing the effect of drought on vegetation. Other indices such as the Vegetation Health Index (VHI) were also developed during this time period, and applied to AVHRR NDVI and brightness temperature data for routine global monitoring of drought conditions. These early efforts demonstrated the unique perspective that global imagers such as AVHRR could provide for operational drought monitoring through their near-daily, global observations of Earth's land surface. However, the advancement of satellite remote sensing of drought was limited by the relatively few spectral bands of operational global sensors such as AVHRR, along with a relatively short period of observational record. Remote sensing advancements are of paramount importance given the increasing demand for tools that can provide accurate, timely, and integrated information on drought conditions to facilitate proactive decision making (NIDIS, 2007). Satellite-based approaches are key to addressing significant gaps in the spatial and temporal coverage of current surface station instrument networks providing key moisture observations (e.g., rainfall, snow, soil moisture, ground water, and ET) over the United States and globally (NIDIS, 2007). Improved monitoring capabilities will be particularly important given increases in spatial extent, intensity, and duration of drought events observed in some regions of the world, as reported in the International Panel on Climate Change (IPCC) report (IPCC, 2007). The risk of drought is anticipated to further increase in some regions in response to climatic changes in the hydrologic cycle related to evaporation, precipitation, air temperature, and snow cover (Burke et al., 2006; IPCC, 2007; USGCRP, 2009). Numerous national, regional, and

  19. Meeting the Demand for Future Dental School Faculty: Trends, Challenges, and Responses.

    ERIC Educational Resources Information Center

    Haden, N. Karl; Weaver, Richard G.; Valachovic, Richard W.

    2002-01-01

    Presents data from the American Dental Education Association's 2001-02 survey of vacant budgeted faculty positions and examines challenges likely to exacerbate faculty shortages in the immediate future. (EV)

  20. Culicoides Latreille (Diptera: Ceratopogonidae) taxonomy: Current challenges and future directions

    PubMed Central

    Harrup, L.E.; Bellis, G.A.; Balenghien, T.; Garros, C.

    2015-01-01

    Culicoides Latreille biting midges (Diptera: Ceratopogonidae) cause a significant biting nuisance to humans, livestock and equines, and are the biological vectors of a range of internationally important pathogens of both veterinary and medical importance. Despite their economic significance, the delimitation and identification of species and evolutionary relationships between species within this genus remains at best problematic. To date no phylogenetic study has attempted to validate the subgeneric classification of the genus and the monophyly of many of the subgenera remains doubtful. Many informal species groupings are also known to exist but few are adequately described, further complicating accurate identification. Recent contributions to Culicoides taxonomy at the species level have revealed a high correlation between morphological and molecular analyses although molecular analyses are revealing the existence of cryptic species. This review considers the methods for studying the systematics of Culicoides using both morphological and genetic techniques, with a view to understanding the factors limiting our current understanding of Culicoides biology and hence arbovirus epidemiology. In addition, we examine the global status of Culicoides identification, highlighting areas that are poorly addressed, including the potential implementation of emerging technologies. PMID:25535946

  1. Organic matter turnover in subsoils: current knowledge and future challenges

    NASA Astrophysics Data System (ADS)

    Marschner, Bernd

    2014-05-01

    In the past, carbon flux measurements and modelling have mostly considered the topsoil where C-concentrations, root densities and microbial activities are generally highest. However, depending on climate zone and land use, this soil compartment contains only 30-50% of the C-stocks of the first meter. If the deeper subsoil down to 3 m is also considered, the contribution of topsoil carbon stocks to total soil C-pools is only 20-40%. Another distinct property of subsoil organic matter is its high apparent 14C age. The 14C age of bulk soil organic matter below 30 cm depth generally increases continuously indicating mean residence times of several 103 to 104 years. Large pool size and high radiocarbon age suggest that subsoil OM has accumulated at very low rates over very long time periods and therefore appears to be very stable. In this review, several hypotheses for explaining why subsoil SOM is so seemingly old and inert are presented. These questions are being addressed in a recently granted German research unit consisting of 9 subprojects from all soil science disciplines using field measurements of C-fluxes, 14C analyses and conducting field and lab experiments.

  2. Progress in interventional cardiology: challenges for the future.

    PubMed

    Simsekyilmaz, Sakine; Liehn, Elisa A; Militaru, Constantin; Vogt, Felix

    2015-03-01

    Cardiovascular disease is the leading cause of death in the western and developing countries. Percutaneous transluminal coronary interventions have become the most prevalent treatment option for coronary artery disease; however, due to serious complications, such as stent thrombosis and in-stent restenosis (ISR), the efficacy and safety of the procedure remain important issues to address. Strategies to overcome these aspects are under extensive investigation. In this review, we summarise relevant milestones during the time to overcome these limitations of coronary stents, such as the development of polymer-free drug-eluting stents (DES) to avoid pro-inflammatory response due to the polymer coating or the developement of stents with cell-directing drugs to, simultaneously, improve re-endothelialisation and inhibit ISR amongst other techniques most recently developed, which have not fully entered the clinical stage. Also the novel concept of fully biodegradable DES featured by the lack of a permanent foreign body promises to be a beneficial and applicable tool to restore a natural vessel with maintained vasomotion and to enable optional subsequent surgical revascularisation. PMID:25608683

  3. Immunotherapy for Prostate Cancer – Recent Developments and Future Challenges

    PubMed Central

    Schweizer, Michael T.; Drake, Charles G.

    2014-01-01

    Since the approval of sipuleucel-T for men with metastatic castrate resistant prostate cancer in 2010, great strides in the development of anti-cancer immunotherapies have been made. Current drug development in this area has focused primarily on antigen specific [i.e. cancer vaccines and antibody based therapies)] or checkpoint inhibitor therapies, with the checkpoint inhibitors perhaps gaining the most attention as of late. Indeed, drugs blocking the inhibitory signal generated by the engagement of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) found on T-cells has emerged as potent means to combat the immunosuppressive milieu. The anti-CTLA-4 monoclonal antibody ipilimumab has already been approved in advanced melanoma and two phase III trials evaluating ipilimumab in men with metastatic castrate-resistant prostate cancer are underway. A phase III trial evaluating ProstVac-VF, a poxvirus-based therapeutic prostate cancer vaccine, is also underway. While there has been reason for encouragement over the past few years, many questions regarding the use of immunotherapies remain. Namely it is unclear what stage of disease is most likely to benefit from these approaches, how best to incorporate said treatments with each other and into our current treatment regimens and which therapy is most appropriate for which disease. Herein we review some of the recent advances in immunotherapy as related to the treatment of prostate cancer and outline some of the challenges that lie ahead. PMID:24477411

  4. Future Accelerator Challenges in Support of High-Energy Physics

    SciTech Connect

    Zisman, Michael S.; Zisman, M.S.

    2008-05-03

    Historically, progress in high-energy physics has largely been determined by development of more capable particle accelerators. This trend continues today with the imminent commissioning of the Large Hadron Collider at CERN, and the worldwide development effort toward the International Linear Collider. Looking ahead, there are two scientific areas ripe for further exploration--the energy frontier and the precision frontier. To explore the energy frontier, two approaches toward multi-TeV beams are being studied, an electron-positron linear collider based on a novel two-beam powering system (CLIC), and a Muon Collider. Work on the precision frontier involves accelerators with very high intensity, including a Super-BFactory and a muon-based Neutrino Factory. Without question, one of the most promising approaches is the development of muon-beam accelerators. Such machines have very high scientific potential, and would substantially advance the state-of-the-art in accelerator design. The challenges of the new generation of accelerators, and how these can be accommodated in the accelerator design, are described. To reap their scientific benefits, all of these frontier accelerators will require sophisticated instrumentation to characterize the beam and control it with unprecedented precision.

  5. Nuclear Power Plant NDE Challenges - Past, Present, and Future

    SciTech Connect

    Doctor, S. R.

    2007-03-21

    The operating fleet of U.S. nuclear power plants was built to fossil plant standards (of workmanship, not fitness for service) and with good engineering judgment. Fortuitously, those nuclear power plants were designed using defense-in-depth concepts, with nondestructive examination (NDE) an important layer, so they can tolerate almost any component failure and still continue to operate safely. In the 30+ years of reactor operation, many material failures have occurred. Unfortunately, NDE has not provided the reliability to detect degradation prior to initial failure (breaching the pressure boundary). However, NDE programs have been improved by moving from prescriptive procedures to performance demonstrations that quantify inspection effectiveness for flaw detection probability and sizing accuracy. Other improvements include the use of risk-informed strategies to ensure that reactor components contributing the most risk receive the best and most frequent inspections. Another challenge is the recent surge of interest in building new nuclear power plants in the United States to meet increasing domestic energy demand. New construction will increase the demand for NDE but also offers the opportunity for more proactive inspections. This paper reviews the inception and evolution of NDE for nuclear power plants over the past 40 years, recounts lessons learned, and describes the needs remaining as existing plants continue operation and new construction is contemplated.

  6. Future prospects and challenges of vaccines against filariasis.

    PubMed

    Babayan, Simon A; Allen, J E; Taylor, D W

    2012-05-01

    Filarial infections remain a major public health and socio-economic problem across the tropics, despite considerable effort to reduce disease burden or regionally eliminate the infection with mass drug administration programmes. The sustainability of these programmes is now open to question owing to a range of issues, not least of which is emerging evidence for drug resistance. Vaccination, if developed appropriately, remains the most cost-effective means of long-term disease control. The rationale for the feasibility of vaccination against filarial parasites including onchocerciasis (river blindness, Onchocerca volvulus) and lymphatic filariasis (Wuchereria bancrofti or Brugia malayi) is founded on evidence from both humans and animal models for the development of protective immunity. Nonetheless, enormous challenges need to be faced in terms of overcoming parasite-induced suppression without inducing pathology as well as the need to both recognize and tackle evolutionary and ecological obstacles to successful vaccine development. Nonetheless, new technological advances in addition to systems biology approaches offer hope that optimal immune responses can be induced that will prevent infection, disease and/or transmission. PMID:22150082

  7. Recent Discoveries and Future Challenges in Atmospheric Organic Chemistry.

    PubMed

    Glasius, Marianne; Goldstein, Allen H

    2016-03-15

    Earth's atmosphere contains a multitude of organic compounds, which differ by orders of magnitude regarding fundamental properties such as volatility, reactivity, and propensity to form cloud droplets, affecting their impact on global climate and human health. Despite recent major research efforts and advances, there are still substantial gaps in understanding of atmospheric organic chemistry, hampering efforts to understand, model, and mitigate environmental problems such as aerosol formation in both polluted urban and more pristine regions. The analytical toolbox available for chemists to study atmospheric organic components has expanded considerably during the past decade, opening new windows into speciation, time resolution and detection of reactive and semivolatile compounds at low concentrations. This has provided unprecedented opportunities, but also unveiled new scientific challenges. Specific groundbreaking examples include the role of epoxides in aerosol formation especially from isoprene, the importance of highly oxidized, reactive organics in air-surface processes (whether atmosphere-biosphere exchange or aerosols), as well as the extent of interactions of anthropogenic and biogenic emissions and the resulting impact on atmospheric organic chemistry. PMID:26862779

  8. Telocytes in the reproductive organs: Current understanding and future challenges.

    PubMed

    Cretoiu, Dragos; Cretoiu, Sanda Maria

    2016-07-01

    Over the past decades, we were witnessing spectacular molecular medicine advances. However, many of the reproductive medicine problems, such as fertility issues and premature birth still represent major challenges for obstetrics and gynecology worldwide. A new cell population - the telocytes (TCs) - were described in the interstitial space of many organs, and their possible implications in many important physiological and pathological processes should not be overlooked. In this article, we present a historical perspective outlining the landmarks in the discovery, evolution and achievements in the field of TCs over the last ten years. We focused on the potential roles of TCs in morphogenesis and maintenance of the normal three-dimensional architecture of tissues, in controlling of the stem cell microenvironment, as having anti-inflammatory and cancer-suppressing properties, participating in the immune surveillance, all mediated by direct homo- and heterocellular junctions or indirectly by extracellular vesicle release. Here, we overview the advances on TCs research in the reproductive organs (uterus and fallopian tube), accessory reproductive organs of female (mammary glands) and the temporary endocrine organ-placenta. PMID:27021165

  9. Retinal pigment epithelium transplantation: concepts, challenges, and future prospects

    PubMed Central

    Alexander, P; Thomson, H A J; Luff, A J; Lotery, A J

    2015-01-01

    The retinal pigment epithelium (RPE) is a single layer of cells that supports the light-sensitive photoreceptor cells that are essential for retinal function. Age-related macular degeneration (AMD) is a leading cause of visual impairment, and the primary pathogenic mechanism is thought to arise in the RPE layer. RPE cell structure and function are well understood, the cells are readily sustainable in laboratory culture and, unlike other cell types within the retina, RPE cells do not require synaptic connections to perform their role. These factors, together with the relative ease of outer retinal imaging, make RPE cells an attractive target for cell transplantation compared with other cell types in the retina or central nervous system. Seminal experiments in rats with an inherited RPE dystrophy have demonstrated that RPE transplantation can prevent photoreceptor loss and maintain visual function. This review provides an update on the progress made so far on RPE transplantation in human eyes, outlines potential sources of donor cells, and describes the technical and surgical challenges faced by the transplanting surgeon. Recent advances in the understanding of pluripotent stem cells, combined with novel surgical instrumentation, hold considerable promise, and support the concept of RPE transplantation as a regenerative strategy in AMD. PMID:26043704

  10. Retinal pigment epithelium transplantation: concepts, challenges, and future prospects.

    PubMed

    Alexander, P; Thomson, H A J; Luff, A J; Lotery, A J

    2015-08-01

    The retinal pigment epithelium (RPE) is a single layer of cells that supports the light-sensitive photoreceptor cells that are essential for retinal function. Age-related macular degeneration (AMD) is a leading cause of visual impairment, and the primary pathogenic mechanism is thought to arise in the RPE layer. RPE cell structure and function are well understood, the cells are readily sustainable in laboratory culture and, unlike other cell types within the retina, RPE cells do not require synaptic connections to perform their role. These factors, together with the relative ease of outer retinal imaging, make RPE cells an attractive target for cell transplantation compared with other cell types in the retina or central nervous system. Seminal experiments in rats with an inherited RPE dystrophy have demonstrated that RPE transplantation can prevent photoreceptor loss and maintain visual function. This review provides an update on the progress made so far on RPE transplantation in human eyes, outlines potential sources of donor cells, and describes the technical and surgical challenges faced by the transplanting surgeon. Recent advances in the understanding of pluripotent stem cells, combined with novel surgical instrumentation, hold considerable promise, and support the concept of RPE transplantation as a regenerative strategy in AMD. PMID:26043704

  11. [Cancer-related Cognitive Impairment: Current Knowledge and Future Challenges].

    PubMed

    Tanimukai, Hitoshi

    2015-01-01

    Cancer patients often suffer from various distresses, including cognitive impairment. Cognitive impairment during and after cancer diagnosis and treatment are collectively called "Cancer-related cognitive impairment (CRCI)". The number of publications about cognitive impairment due to cancer therapy, especially chemotherapy, hormonal therapy, and radiotherapy, has been growing. Patients often worry not only about their disease condition and therapies, but also experience concerns regarding their memory, attention, and ability to concentrate. Even subtle CRCI can have a significant impact on social relationships, the ability to work, undergo treatment, accomplish meaningful goals, and the quality of life. Longitudinal studies of cancer patients indicated that up to 75% experience CRCI during treatment. Furthermore, CRCI may persist for many years following treatment. However, it is not well understood by most physicians and medical staff. CRCI can be mediated through increased inflammatory cytokines and hormonal changes. In addition, the biology of the cancer, stress, and attentional fatigue can also contribute to CRCI. Genetic factors and co-occurring symptoms may explain some of the inter-individual variability in CRCI. Researchers and patients are actively trying to identify effective interventional methods and useful coping strategies. Many patients are willing to discuss their disease condition and future treatment with medical staff and/or their families. Some patients also hope to discuss their end-of-life care. However, it is difficult to express their will after developing cognitive impairment. Advance care planning (ACP) can help in such situations. This process involves discussion between a patient, their family, and clinicians to clarify and reflect on values, treatment preferences, and goals to develop a shared understanding of how end-of-life care should proceed. The number of cancer patients with cognitive impairment has been increasing owing to the

  12. Addressing the Photometric Calibration Challenge: Explicit Determination of the Instrumental Response and Atmospheric Response Functions, and Tying it All Together.

    NASA Astrophysics Data System (ADS)

    Stubbs, C. W.; Tonry, J. L.

    2016-05-01

    Photometric calibration is currently the dominant source of systematic uncertainty in exploiting type Ia supernovae to determine the nature of the dark energy. We review our ongoing program to address this calibration challenge by performing measurements of both the instrumental response function and the optical transmission function of the atmosphere. A key aspect of this approach is to complement standard star observations by using NIST-calibrated photodiodes as a metrology foundation for optical flux measurements. We present our first attempt to assess photometric consistency between synthetic photometry and observations, by comparing predictions based on a NIST-diode-based determination of the PanSTARRS-1 instrumental response and empirical atmospheric transmission measurements, with fluxes we obtained from observing spectrophotometric standards.

  13. Proteins interacting with monoamine transporters: current state and future challenges.

    PubMed

    Sager, Jonathan J; Torres, Gonzalo E

    2011-08-30

    Plasma membrane and vesicular transporters for the biogenic amines, dopamine, norepinephrine, and serotonin, represent a group of proteins that play a crucial role in the regulation of neurotransmission. Clinically, mono amine transporters are the primary targets for the actions of many therapeutic agents used to treat mood disorders, as well as the site of action for highly addictive psychostimulants such as cocaine, amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine. Over the past decade, the use of approaches such as yeast two-hybrid and proteomics has identified a multitude of transporter interacting proteins, suggesting that the function and regulation of these transporters are more complex than previously anticipated. With the increasing number of interacting proteins, the rules dictating transporter synthesis, assembly, targeting, trafficking, and function are beginning to be deciphered. Although many of these protein interactions have yet to be fully characterized, current knowledge is beginning to shed light on novel transporter mechanisms involved in monoamine homeostasis, the molecular actions of psychostimulants, and potential disease mechanisms. While future studies resolving the spatial and temporal resolution of these, and yet unknown, interactions will be needed, the realization that monoamine transporters do not work alone opens the path to a plethora of possible pharmacological interventions. PMID:21797260

  14. Water management in Egypt for facing the future challenges

    PubMed Central

    Omar, Mohie El Din M.; Moussa, Ahmed M.A.

    2016-01-01

    The current water shortage in Egypt is 13.5 Billion cubic meter per year (BCM/yr) and is expected to continuously increase. Currently, this water shortage is compensated by drainage reuse which consequently deteriorates the water quality. Therefore, this research was commenced with the objective of assessing different scenarios for 2025 using the Water Evaluation and Planning (WEAP) model and by implementing different water sufficiency measures. Field data were assembled and analyzed, and different planning alternatives were proposed and tested in order to design three future scenarios. The findings indicated that water shortage in 2025 would be 26 BCM/yr in case of continuation of current policies. Planning alternatives were proposed to the irrigation canals, land irrigation timing, aquatic weeds in waterways and sugarcane areas in old agricultural lands. Other measures were suggested to pumping rates of deep groundwater, sprinkler and drip irrigation systems in new agricultural lands. Further measures were also suggested to automatic daily surveying for distribution leak and managing the pressure effectively in the domestic and industrial water distribution systems. Finally, extra measures for water supply were proposed including raising the permitted withdrawal limit from deep groundwater and the Nubian aquifer and developing the desalination resource. The proposed planning alternatives would completely eliminate the water shortage in 2025. PMID:27222745

  15. Ebola: lessons learned and future challenges for Europe.

    PubMed

    Quaglio, GianLuca; Goerens, Charles; Putoto, Giovanni; Rübig, Paul; Lafaye, Pierre; Karapiperis, Theodoros; Dario, Claudio; Delaunois, Paul; Zachariah, Rony

    2016-02-01

    The Ebola virus epidemic has topped media and political agendas for months; several countries in west Africa have faced the worst Ebola epidemic in history. At the beginning of the disease outbreak, European Union (EU) policies were notably absent regarding how to respond to the crisis. Although the epidemic is now receding from public view, this crisis has undoubtedly changed the European public perception of Ebola virus disease, which is no longer regarded as a bizarre entity confined in some unknown corner in Africa. Policy makers and researchers in Europe now have an opportunity to consider the lessons learned. In this Personal View, we discuss the EU's response to the Ebola crisis in west Africa. Unfortunately, although ample resources and opportunities for humanitarian and medical action existed, the EU did not use them to promote a rapid and well coordinated response to the Ebola crisis. Lessons learned from this crisis should be used to improve the role of the EU in similar situations in the future, ensuring that European aid can be effectively deployed to set up an improved emergency response system, and supporting the establishment of sustainable health-care services in west Africa. PMID:26627138

  16. Water management in Egypt for facing the future challenges.

    PubMed

    Omar, Mohie El Din M; Moussa, Ahmed M A

    2016-05-01

    The current water shortage in Egypt is 13.5 Billion cubic meter per year (BCM/yr) and is expected to continuously increase. Currently, this water shortage is compensated by drainage reuse which consequently deteriorates the water quality. Therefore, this research was commenced with the objective of assessing different scenarios for 2025 using the Water Evaluation and Planning (WEAP) model and by implementing different water sufficiency measures. Field data were assembled and analyzed, and different planning alternatives were proposed and tested in order to design three future scenarios. The findings indicated that water shortage in 2025 would be 26 BCM/yr in case of continuation of current policies. Planning alternatives were proposed to the irrigation canals, land irrigation timing, aquatic weeds in waterways and sugarcane areas in old agricultural lands. Other measures were suggested to pumping rates of deep groundwater, sprinkler and drip irrigation systems in new agricultural lands. Further measures were also suggested to automatic daily surveying for distribution leak and managing the pressure effectively in the domestic and industrial water distribution systems. Finally, extra measures for water supply were proposed including raising the permitted withdrawal limit from deep groundwater and the Nubian aquifer and developing the desalination resource. The proposed planning alternatives would completely eliminate the water shortage in 2025. PMID:27222745

  17. Future of printing: changes and challenges, technologies and markets

    NASA Astrophysics Data System (ADS)

    Kipphan, Helmut

    1998-01-01

    Digitalization within the graphic arts industry is described and it is explained how it is improving and changing the print production strategies and which new kinds of print production systems are developed or can be expected. The relationship of printed media and electronic media is analyzed and a positioning for the next century is given. The state of the art of conventional printing technologies, especially using direct imagine techniques, and their position within the digital workflow are shortly described. Non-impact printing multicolor printing systems are explained, based on general design criteria and linked to existing and newly announced equipment. The use of high-tech components for building up successful systems with high reliability, high quality and low production costs is included with some examples. Digital printing systems open many opportunities in print production: distributed printing, personalization, print and book on demand are explained as examples. The overview of the several printing technologies and their positioning regarding quality and productivity leads to the scenario about the important position of printed media, also in the distant future.

  18. Infectious Diseases, Urbanization and Climate Change: Challenges in Future China

    PubMed Central

    Tong, Michael Xiaoliang; Hansen, Alana; Hanson-Easey, Scott; Cameron, Scott; Xiang, Jianjun; Liu, Qiyong; Sun, Yehuan; Weinstein, Philip; Han, Gil-Soo; Williams, Craig; Bi, Peng

    2015-01-01

    China is one of the largest countries in the world with nearly 20% of the world’s population. There have been significant improvements in economy, education and technology over the last three decades. Due to substantial investments from all levels of government, the public health system in China has been improved since the 2003 severe acute respiratory syndrome (SARS) outbreak. However, infectious diseases still remain a major population health issue and this may be exacerbated by rapid urbanization and unprecedented impacts of climate change. This commentary aims to explore China’s current capacity to manage infectious diseases which impair population health. It discusses the existing disease surveillance system and underscores the critical importance of strengthening the system. It also explores how the growing migrant population, dramatic changes in the natural landscape following rapid urbanization, and changing climatic conditions can contribute to the emergence and re-emergence of infectious disease. Continuing research on infectious diseases, urbanization and climate change may inform the country’s capacity to deal with emerging and re-emerging infectious diseases in the future. PMID:26371017

  19. Infectious Diseases, Urbanization and Climate Change: Challenges in Future China.

    PubMed

    Tong, Michael Xiaoliang; Hansen, Alana; Hanson-Easey, Scott; Cameron, Scott; Xiang, Jianjun; Liu, Qiyong; Sun, Yehuan; Weinstein, Philip; Han, Gil-Soo; Williams, Craig; Bi, Peng

    2015-09-01

    China is one of the largest countries in the world with nearly 20% of the world's population. There have been significant improvements in economy, education and technology over the last three decades. Due to substantial investments from all levels of government, the public health system in China has been improved since the 2003 severe acute respiratory syndrome (SARS) outbreak. However, infectious diseases still remain a major population health issue and this may be exacerbated by rapid urbanization and unprecedented impacts of climate change. This commentary aims to explore China's current capacity to manage infectious diseases which impair population health. It discusses the existing disease surveillance system and underscores the critical importance of strengthening the system. It also explores how the growing migrant population, dramatic changes in the natural landscape following rapid urbanization, and changing climatic conditions can contribute to the emergence and re-emergence of infectious disease. Continuing research on infectious diseases, urbanization and climate change may inform the country's capacity to deal with emerging and re-emerging infectious diseases in the future. PMID:26371017

  20. Pediatric hypertension: recent trends and accomplishments, future challenges.

    PubMed

    Flynn, Joseph T

    2008-06-01

    Publication of the Fourth Report on high blood pressure (BP) in children and adolescents by the National High BP Education Program (NHBPEP) in 2004 has been followed by a remarkable increase in interest in pediatric hypertension. New data have emerged on the epidemiology of hypertension in the young, the influence of the childhood obesity epidemic on BP, how ambulatory BP monitoring (ABPM) can be used in evaluating elevated BP and the extent of hypertensive target-organ damage in the pediatric age group. Exciting new information on drug treatment of pediatric hypertension has been produced by industry-sponsored clinical trials of antihypertensive medications spurred by the FDA Modernization Act (FDAMA) and successor legislation. Despite these trends, recognition of elevated BP in children and adolescents by primary care providers remains problematic. This article will highlight these and other aspects of pediatric hypertension, hopefully providing a snapshot of where we are in early 2008, and pointing out areas where further work is needed in order to reduce the future burden of adult cardiovascular disease. PMID:18437129

  1. Vascular Complications and Diabetes: Current Therapies and Future Challenges

    PubMed Central

    Willard, Abbott L.; Herman, Ira M.

    2012-01-01

    Diabetic retinal complications, including macular edema (DME) and proliferative diabetic retinopathy (PDR), are the leading cause of new cases of blindness among adults aged 20–74. Chronic hyperglycemia, considered the underlying cause of diabetic retinopathy, is thought to act first through violation of the pericyte-endothelial coupling. Disruption of microvascular integrity leads to pathologic consequences including hypoxia-induced imbalance in vascular endothelial growth factor (VEGF) signaling. Several anti-VEGF medications are in clinical trials for use in arresting retinal angiogenesis arising from DME and PDR. Although a review of current clinical trials shows promising results, the lack of large prospective studies, head-to-head therapeutic comparisons, and potential long-term and systemic adverse events give cause for optimistic caution. Alternative therapies including targeting pathogenic specific angiogenesis and mural-cell-based therapeutics may offer innovative solutions for currently intractable clinical problems. This paper describes the mechanisms behind diabetic retinal complications, current research supporting anti-VEGF medications, and future therapeutic directions. PMID:22272370

  2. Bioenergy crop models: Descriptions, data requirements and future challenges

    SciTech Connect

    Nair, S. Surendran; Kang, Shujiang; Zhang, Xuesong; Miguez, Fernando; Izaurralde, Dr. R. Cesar; Post, Wilfred M; Dietze, Michael; Lynd, L.; Wullschleger, Stan D

    2012-01-01

    Field studies that address the production of lignocellulosic biomass as a source of renewable energy provide critical data for the development of bioenergy crop models. A literature survey revealed that 14 models have been used for simulating bioenergy crops including herbaceous and woody bioenergy crops, and for crassulacean acid metabolism (CAM) crops. These models simulate field-scale production of biomass for switchgrass (ALMANAC, EPIC, and Agro-BGC), miscanthus (MISCANFOR, MISCANMOD, and WIMOVAC), sugarcane (APSIM, AUSCANE, and CANEGRO), and poplar and willow (SECRETS and 3PG). Two models are adaptations of dynamic global vegetation models and simulate biomass yields of miscanthus and sugarcane at regional scales (Agro-IBIS and LPJmL). Although it lacks the complexity of other bioenergy crop models, the environmental productivity index (EPI) is the only model used to estimate biomass production of CAM (Agave and Opuntia) plants. Except for the EPI model, all models include representations of leaf area dynamics, phenology, radiation interception and utilization, biomass production, and partitioning of biomass to roots and shoots. A few models simulate soil water, nutrient, and carbon cycle dynamics, making them especially useful for assessing the environmental consequences (e.g., erosion and nutrient losses) associated with the large-scale deployment of bioenergy crops. The rapid increase in use of models for energy crop simulation is encouraging; however, detailed information on the influence of climate, soils, and crop management practices on biomass production is scarce. Thus considerable work remains regarding the parameterization and validation of process-based models for bioenergy crops; generation and distribution of high-quality field data for model development and validation; and implementation of an integrated framework for efficient, high-resolution simulations of biomass production for use in planning sustainable bioenergy systems.

  3. Multigenerational Challenges and the Future of Graduate Medical Education

    PubMed Central

    Boysen, Philip G.; Daste, Laurie; Northern, Theresa

    2016-01-01

    Background: Demographics are changing on a global scale. In the United States, an aging population continues to work, either by preference or because of insufficient resources to retire. Of even greater importance, a younger generation, referred to as the Millennial Generation, will soon predominate in the workforce and even now accounts for nearly 100% of resident physicians. By the year 2020, there will be 5 generations in the workplace. Methods: This paper defines and details the characteristics of the 5 generations and examines how the vision, attitudes, values, and expectations of the most recent generations will reshape the workforce and graduate medical education. Results: The need for change is imminent to educate the next generation of physicians. Among the changes necessary to adapt to the multigenerational challenges ahead are adopting mobile devices as preferred communication tools; using social networking sites to recruit residents; adding games, simulations, and interactive videos to the curriculum to engage students; breaking down departmental silos and forming learning teams that come from different specialties; developing benchmarks and milestones to measure progress; extending the social learning ecosystem beyond the resident years; embracing diversity as the norm for both practice and learning; and providing both coaching and mentoring. Conclusion: For decades, resident physicians have shown commitment, tenacity, and selflessness while shouldering the dual responsibility of patient care and the pursuit of their own education and skills development. Resident engagement has been shown to drive change in undergraduate medical education and in the learning and performance of their teachers. The latter is evidence of reverse mentoring that will be a major factor for improvement in this digital age. We have only to embrace this opportunity to the benefit of our patients, our learners, and ourselves. PMID:27046415

  4. Telecytology: Clinical applications, current challenges, and future benefits

    PubMed Central

    Thrall, Michael; Pantanowitz, Liron; Khalbuss, Walid

    2011-01-01

    Telecytology is the interpretation of cytology material at a distance using digital images. For more than a decade, pioneering efforts to introduce telecytology into clinical practice have been reported. A Medline search for “telecytology” and “cytology” reveals a voluminous literature, though much of what has been published to date is based on technologies that are rapidly becoming obsolete. The technological limitations of previous techniques, including the transmission of static digital images and dynamic streaming images, have limited telecytology to minor niches. The primary problem with these technologies is that the remote viewer can only see a small fraction of the material on the original slides, introducing the possibility of diagnostic error based not only on image quality but also on image selection. Remote robotic microscopy offers one possible solution to this problem, but to date has found limited acceptance, principally attributable to slow operating times. Whole slide imaging seems to be a much more promising solution, though cytology-specific literature regarding its use is still scant. The advent of whole slide imaging opens up new possibilities for telecytology by enabling high-quality images of entire cytology specimens to be available to anyone, anywhere via the Internet. Although challenges remain, especially with regard to capturing the full microscopy experience including multiple planes of focus and sharp high-powered images, rapidly advancing technology promises to overcome these limitations. Increasing application of whole slide imaging technology in surgical pathology will undoubtedly also increase its application to cytology due to the increasing affordability and practicality of the equipment as it serves a larger number of useful roles within a pathology department. The current and expanding applications of telecytology for clinical practice, education, quality assurance, and testing will be reviewed. PMID:22276242

  5. Future nuclear fuel cycles: Prospect and challenges for actinide recycling

    NASA Astrophysics Data System (ADS)

    Warin, Dominique

    2010-03-01

    The global energy context pleads in favour of a sustainable development of nuclear energy since the demand for energy will likely increase, whereas resources will tend to get scarcer and the prospect of global warming will drive down the consumption of fossil fuel. In this context, nuclear power has the worldwide potential to curtail the dependence on fossil fuels and thereby to reduce the amount of greenhouse gas emissions while promoting energy independence. How we deal with nuclear radioactive waste is crucial in this context. In France, the public's concern regarding the long-term waste management made the French Governments to prepare and pass the 1991 and 2006 Acts, requesting in particular the study of applicable solutions for still minimizing the quantity and the hazardousness of final waste. This necessitates High Active Long Life element (such as the Minor Actinides MA) recycling, since the results of fuel cycle R&D could significantly change the challenges for the storage of nuclear waste. HALL recycling can reduce the heat load and the half-life of most of the waste to be buried to a couple of hundred years, overcoming the concerns of the public related to the long-life of the waste and thus aiding the "burying approach" in securing a "broadly agreed political consensus" of waste disposal in a geological repository. This paper presents an overview of the recent R and D results obtained at the CEA Atalante facility on innovative actinide partitioning hydrometallurgical processes. For americium and curium partitioning, these results concern improvements and possible simplifications of the Diamex-Sanex process, whose technical feasibility was already demonstrated in 2005. Results on the first tests of the Ganex process (grouped actinide separation for homogeneous recycling) are also discussed. In the coming years, next steps will involve both better in-depth understanding of the basis of these actinide partitioning processes and, for the new promising

  6. Geomorphology of ice stream beds: recent progress and future challenges

    NASA Astrophysics Data System (ADS)

    Stokes, Chris R.

    2016-04-01

    Ice sheets lose mass primarily by melting and discharge via rapidly-flowing ice streams. Surface and basal melting (e.g. of ice shelves) are closely linked to atmospheric and oceanic conditions, but the mechanisms that drive changes in ice stream discharge are more complex; and are influenced by conditions at their bed which can sustain, enhance or inhibit their motion. Although explicit comparisons are rare, the ice-bed interface is similar to the 'boundary layer' in fluvial and aeolian environments, where shear stresses (both basal and lateral in the case of ice streams) oppose the flow of the overlying medium. The analogy extends further because processes within the boundary layer create a distinctive geomorphology (and roughness) that is characterised by subglacial bedforms that resemble features in fluvial and aeolian environments. Their creation results from erosion, transport and deposition of sediment which is poorly constrained, but which is intimately linked to the mechanisms through which ice streams are able to flow rapidly. The study of ice stream geomorphology is, therefore, critical to our understanding of their dynamics. Despite difficulty in observing the subglacial environment of active ice streams, our understanding of their geomorphology has grown rapidly in the last three decades, from almost complete ignorance to a detailed knowledge of their geomorphological products. This has been brought about by two main approaches: (i) geophysical investigation of modern (active) ice streams, and (ii) sedimentological and geomorphological investigation of palaeo-ice stream beds. The aim of this paper is to review progress in these two areas, highlight the key questions that remain, and discuss the opportunities that are likely to arise that will enable them to be addressed. It is clear that whilst these two main approaches have led to important advances, they have often been viewed as separate sub-disciplines, with minimal cross-pollination of ideas and

  7. Support for international agricultural research: current status and future challenges.

    PubMed

    Zeigler, Robert S; Mohanty, Samarendu

    2010-11-30

    The success of the first Green Revolution in the form of abundant food supplies and low prices over the past two decades has diverted the world's attention from agriculture to other pressing issues. This has resulted in lower support for the agricultural research work primarily undertaken by the 15 research centers of the Consultative Group on International Agricultural Research (CGIAR). The total support in real dollars for most of the last three decades has been more or less flat although the number of centers increased from 4 to 15. However, since 2000, the funding situation has improved for the CGIAR centers, with almost all the increase coming from grants earmarked for specific research projects. Even for some centers such as the International Rice Research Institute (IRRI), the downward trend continued as late as 2006 with the budget in real dollars reaching the 1978 level of support. The recent food crisis has renewed the call for a second Green Revolution by revitalizing yield growth to feed the world in the face of growing population and a shrinking land base for agricultural use. The slowdown in yield growth because of decades of neglect in agricultural research and infrastructure development has been identified as the underlying reason for the recent food crisis. For the second Green Revolution to be successful, the CGIAR centers will have to play a complex role by expanding productivity in a sustainable manner with fewer resources. Thus, it is crucial to examine the current structure of support for the CGIAR centers and identify the challenges ahead in terms of source and end use of funds for the success of the second Green Revolution. The objective of this paper is to provide a historical perspective on the support to the CGIAR centers and to examine the current status of funding, in particular, the role of project-specific grants in rebuilding capacity of these centers. The paper will also discuss the nature of the support (unrestricted vs. project

  8. Erosion in Mediterranean landscapes: Changes and future challenges

    NASA Astrophysics Data System (ADS)

    García-Ruiz, José M.; Nadal-Romero, Estela; Lana-Renault, Noemí; Beguería, Santiago

    2013-09-01

    Intense erosion processes are widespread in the Mediterranean region, and include sheet wash erosion, rilling, gullying, shallow landsliding, and the development of large and active badlands in both subhumid and semi-arid areas. This review analyses the main environmental and human features related to soil erosion processes, and the main factors that explain the extreme variability of factors influencing soil erosion, particularly recent land use changes. The importance of erosion in the Mediterranean is related to the long history of human activity in a region characterized by low levels of annual precipitation, the occurrence of intense rainstorms and long-lasting droughts, high evapotranspiration, the presence of steep slopes and the occurrence of recent tectonic activity, together with the recurrent use of fire, overgrazing and farming. These factors have resulted in a complex landscape in which intensification and abandonment, wealth and poverty can co-exist. The changing conditions of national and international markets and the evolution of population pressure are now the main drivers explaining land use changes, including farmland abandonment in mountain areas, the expansion of some subsidized crops to marginal lands, and the development of new terraces affected by landslides and intense soil erosion during extreme rainstorm events. The occurrence of human-related forest fires affecting thousands of hectares each year is a significant problem in both the northern and southern areas of the Mediterranean basin. Here, we highlight the rise of new scientific challenges in controlling the negative consequences of soil erosion in the Mediterranean region: 1) to reduce the effects and extent of forest fires, and restructure the spatial organization of abandoned landscapes; 2) to provide guidance for making the EU agricultural policy more adapted to the complexity and fragility of Mediterranean environments; 3) to develop field methods and models to improve the

  9. Moving NASA Beyond Low Earth Orbit: Future Human-Automation-Robotic Integration Challenges

    NASA Technical Reports Server (NTRS)

    Marquez, Jessica

    2016-01-01

    This presentation will provide an overview of current human spaceflight operations. It will also describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. Additionally, there are many implications regarding advanced automation and robotics, and this presentation will outline future human-automation-robotic integration challenges.

  10. Detecting Chemical Weapons: Threats, Requirements, Solutions, and Future Challenges

    NASA Astrophysics Data System (ADS)

    Boso, Brian

    2011-03-01

    mobility spectrometry, and amplifying fluorescence polymers. In the future the requirements for detection equipment will continue to become even more stringent. The continuing increase in the sheer number of threats that will need to be detected, the development of binary agents requiring that even the precursor chemicals be detected, the development of new types of agents unlike any of the current chemistries, and the expansion of the list of toxic industrial chemical will require new techniques with higher specificity and more sensitivity.

  11. Past and future challenges from a display mask writer perspective

    NASA Astrophysics Data System (ADS)

    Ekberg, Peter; von Sydow, Axel

    2012-06-01

    Since its breakthrough, the liquid crystal technology has continued to gain momentum and the LCD is today the dominating display type used in desktop monitors, television sets, mobile phones as well as other mobile devices. To improve production efficiency and enable larger screen sizes, the LCD industry has step by step increased the size of the mother glass used in the LCD manufacturing process. Initially the mother glass was only around 0.1 m2 large, but with each generation the size has increased and with generation 10 the area reaches close to 10 m2. The increase in mother glass size has in turn led to an increase in the size of the photomasks used - currently the largest masks are around 1.6 × 1.8 meters. A key mask performance criterion is the absence of "mura" - small systematic errors captured only by the very sensitive human eye. To eliminate such systematic errors, special techniques have been developed by Micronic Mydata. Some mura suppressing techniques are described in this paper. Today, the race towards larger glass sizes has come to a halt and a new race - towards higher resolution and better image quality - is ongoing. The display mask is therefore going through a change that resembles what the semiconductor mask went through some time ago: OPC features are introduced, CD requirements are increasing sharply and multi tone masks (MTMs) are widely used. Supporting this development, Micronic Mydata has introduced a number of compensation methods in the writer, such as Z-correction, CD map and distortion control. In addition, Micronic Mydata MMS15000, the world's most precise large area metrology tool, has played an important role in improving mask placement quality and is briefly described in this paper. Furthermore, proposed specifications and system architecture concept for a new generation mask writers - able to fulfill future image quality requirements - is presented in this paper. This new system would use an AOD/AOM writing engine and be

  12. Hepatitis C in the Russian Federation: challenges and future directions

    PubMed Central

    Mukomolov, Sergey; Trifonova, Galina; Levakova, Irina; Bolsun, Daria; Krivanogova, Eugenia

    2016-01-01

    carcinoma will be seen in the near future that will require urgent preventive and therapeutic measures. PMID:27217802

  13. Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective.

    PubMed

    Díaz-Zuccarini, V; Narracott, A J; Burriesci, G; Zervides, C; Rafiroiu, D; Jones, D; Hose, D R; Lawford, P V

    2009-07-13

    This paper describes the use of diverse software tools in cardiovascular applications. These tools were primarily developed in the field of engineering and the applications presented push the boundaries of the software to address events related to venous and arterial valve closure, exploration of dynamic boundary conditions or the inclusion of multi-scale boundary conditions from protein to organ levels. The future of cardiovascular research and the challenges that modellers and clinicians face from validation to clinical uptake are discussed from an end-user perspective. PMID:19487202

  14. Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective

    PubMed Central

    Díaz-Zuccarini, V.; Narracott, A.J.; Burriesci, G.; Zervides, C.; Rafiroiu, D.; Jones, D.; Hose, D.R.; Lawford, P.V.

    2009-01-01

    This paper describes the use of diverse software tools in cardiovascular applications. These tools were primarily developed in the field of engineering and the applications presented push the boundaries of the software to address events related to venous and arterial valve closure, exploration of dynamic boundary conditions or the inclusion of multi-scale boundary conditions from protein to organ levels. The future of cardiovascular research and the challenges that modellers and clinicians face from validation to clinical uptake are discussed from an end-user perspective. PMID:19487202

  15. Progress in aptamer-mediated drug delivery vehicles for cancer targeting and its implications in addressing chemotherapeutic challenges.

    PubMed

    Zhu, Jie; Huang, He; Dong, Shiwu; Ge, Liang; Zhang, Yuan

    2014-01-01

    Aptamers are novel oligonucleotides with flexible three-dimensional configurations that recognize and bind to their cognate targets, including tumor surface receptors, in a high-affinity and highly specific manner. Because of their unique intrinsic properties, a variety of aptamer-mediated nanovehicles have been developed to directionally transport anti-cancer drugs to tumor sites to minimize systemic cytotoxicity and to enhance permeation by these tumoricidal agents. Despite advances in the selection and synthesis of aptamers and in the conjugation and self-assembly of nanotechnologies, current chemotherapy and drug delivery systems face great challenges. These challenges are due to the limitations of aptamers and vehicles and because of complicated tumor mechanisms, including heterogeneity, anti-cancer drug resistance, and hypoxia-induced aberrances. In this review, we will summarize current approaches utilizing tumor surface hallmarks and aptamers and their roles and mechanisms in therapeutic nanovehicles targeting tumors. Delivery forms include nanoparticles, nanotubes, nanogels, aptamer-drug conjugates, and novel molecular trains. Moreover, the obstacles posed by the aforementioned issues will be highlighted, and possible solutions will be acknowledged. Furthermore, future perspectives will be presented, including cutting-edge integration with RNA interference nanotechnology and personalized chemotherapy, which will facilitate innovative approaches to aptamer-based therapeutics. PMID:25057317

  16. Progress in Aptamer-Mediated Drug Delivery Vehicles for Cancer Targeting and Its Implications in Addressing Chemotherapeutic Challenges

    PubMed Central

    Zhu, Jie; Huang, He; Dong, Shiwu; Ge, Liang; Zhang, Yuan

    2014-01-01

    Aptamers are novel oligonucleotides with flexible three-dimensional configurations that recognize and bind to their cognate targets, including tumor surface receptors, in a high-affinity and highly specific manner. Because of their unique intrinsic properties, a variety of aptamer-mediated nanovehicles have been developed to directionally transport anti-cancer drugs to tumor sites to minimize systemic cytotoxicity and to enhance permeation by these tumoricidal agents. Despite advances in the selection and synthesis of aptamers and in the conjugation and self-assembly of nanotechnologies, current chemotherapy and drug delivery systems face great challenges. These challenges are due to the limitations of aptamers and vehicles and because of complicated tumor mechanisms, including heterogeneity, anti-cancer drug resistance, and hypoxia-induced aberrances. In this review, we will summarize current approaches utilizing tumor surface hallmarks and aptamers and their roles and mechanisms in therapeutic nanovehicles targeting tumors. Delivery forms include nanoparticles, nanotubes, nanogels, aptamer-drug conjugates, and novel molecular trains. Moreover, the obstacles posed by the aforementioned issues will be highlighted, and possible solutions will be acknowledged. Furthermore, future perspectives will be presented, including cutting-edge integration with RNA interference nanotechnology and personalized chemotherapy, which will facilitate innovative approaches to aptamer-based therapeutics. PMID:25057317

  17. English for Scientific Purposes (EScP): Technology, Trends, and Future Challenges for Science Education

    NASA Astrophysics Data System (ADS)

    Liu, Gi-Zen; Chiu, Wan-Yu; Lin, Chih-Chung; Barrett, Neil E.

    2014-09-01

    To date, the concept of English for Specific Purposes has brought about a great impact on English language learning across various disciplines, including those in science education. Hence, this review paper aimed to address current English language learning in the science disciplines through the practice of computer-assisted language learning to identify the use of learning technologies in science-based literacy. In the literature review, the researchers found that science-based literacy instruction shares many pedagogical aims with English language teaching in terms of reading, writing, listening and speaking, allowing it to be classified as English for Scientific Purposes (EScP). To answer the research questions, the researchers conducted the survey by extracting related articles and teaching examples from the Web of Science. In the search procedure, the researchers used the keywords science OR scientific AND technolog* OR comput* in ten selected journals of social science citation index. Only articles which are specified as journal articles rather than other document types were included. After compiling the corpora, the researchers compared the trends, methodologies and results of EScP instruction in science education. The implications of this study include the opportunities, advantages and challenges for EScP instruction in science education to further develop better educational approaches, adopt new technologies, as well as offer some directions for researchers to conduct future studies.

  18. Intelligent Assistive Technology Applications to Dementia Care: Current Capabilities, Limitations, and Future Challenges

    PubMed Central

    Bharucha, Ashok J.; Anand, Vivek; Forlizzi, Jodi; Dew, Mary Amanda; Reynolds, Charles F.; Stevens, Scott; Wactlar, Howard

    2009-01-01

    The number of older Americans afflicted by Alzheimer disease and related dementias will triple to 13 million persons by 2050, thus greatly increasing healthcare needs. An approach to this emerging crisis is the development and deployment of intelligent assistive technologies that compensate for the specific physical and cognitive deficits of older adults with dementia, and thereby also reduce caregiver burden. The authors conducted an extensive search of the computer science, engineering, and medical databases to review intelligent cognitive devices, physiologic and environmental sensors, and advanced integrated sensor networks that may find future applications in dementia care. Review of the extant literature reveals an overwhelming focus on the physical disability of younger persons with typically nonprogressive anoxic and traumatic brain injuries, with few clinical studies specifically involving persons with dementia. A discussion of the specific capabilities, strengths, and limitations of each technology is followed by an overview of research methodological challenges that must be addressed to achieve measurable progress to meet the healthcare needs of an aging America. PMID:18849532

  19. English for Scientific Purposes (EScP): Technology, Trends, and Future Challenges for Science Education

    NASA Astrophysics Data System (ADS)

    Liu, Gi-Zen; Chiu, Wan-Yu; Lin, Chih-Chung; Barrett, Neil E.

    2014-12-01

    To date, the concept of English for Specific Purposes has brought about a great impact on English language learning across various disciplines, including those in science education. Hence, this review paper aimed to address current English language learning in the science disciplines through the practice of computer-assisted language learning to identify the use of learning technologies in science-based literacy. In the literature review, the researchers found that science-based literacy instruction shares many pedagogical aims with English language teaching in terms of reading, writing, listening and speaking, allowing it to be classified as English for Scientific Purposes (EScP). To answer the research questions, the researchers conducted the survey by extracting related articles and teaching examples from the Web of Science. In the search procedure, the researchers used the keywords science OR scientific AND technolog* OR comput* in ten selected journals of social science citation index. Only articles which are specified as journal articles rather than other document types were included. After compiling the corpora, the researchers compared the trends, methodologies and results of EScP instruction in science education. The implications of this study include the opportunities, advantages and challenges for EScP instruction in science education to further develop better educational approaches, adopt new technologies, as well as offer some directions for researchers to conduct future studies.

  20. Addressing challenges of training a new generation of clinician-innovators through an interdisciplinary medical technology design program: Bench-to-Bedside.

    PubMed

    Loftus, Patrick D; Elder, Craig T; D'Ambrosio, Troy; Langell, John T

    2015-01-01

    Graduate medical education has traditionally focused on training future physicians to be outstanding clinicians with basic and clinical science research skills. This focus has resulted in substantial knowledge gains, but a modest return on investment based on direct improvements in clinical care. In today's shifting healthcare landscape, a number of important challenges must be overcome to not only improve the delivery of healthcare, but to prepare future physicians to think outside the box, focus on and create healthcare innovations, and navigate the complex legal, business and regulatory hurdles of bringing innovation to the bedside. We created an interdisciplinary and experiential medical technology design competition to address these challenges and train medical students interested in moving new and innovative clinical solutions to the forefront of medicine. Medical students were partnered with business, law, design and engineering students to form interdisciplinary teams focused on developing solutions to unmet clinical needs. Over the course of six months teams were provided access to clinical and industry mentors, $500 prototyping funds, development facilities, and non-mandatory didactic lectures in ideation, design, intellectual property, FDA regulatory requirements, prototyping, market analysis, business plan development and capital acquisition. After four years of implementation, the program has supported 396 participants, seen the development of 91 novel medical devices, and launched the formation of 24 new companies. From our perspective, medical education programs that develop innovation training programs and shift incentives from purely traditional basic and clinical science research to also include high-risk innovation will see increased student engagement in improving healthcare delivery and an increase in the quality and quantity of innovative solutions to medical problems being brought to market. PMID:25984273

  1. Principles of Positive Behaviour Supports: Using the FBA as a Problem-Solving Approach to Address Challenging Behaviours beyond Special Populations

    ERIC Educational Resources Information Center

    Moreno, Gerardo; Bullock, Lyndal M.

    2011-01-01

    The Functional Behavioural Assessment (FBA) is an investigative process that examines the context of challenging behaviours in the classroom. Information gleaned from the FBA process is used to develop a behaviour intervention plan to address the challenging behaviour and teach a socially acceptable replacement behaviour. However, the FBA has…

  2. Building organizational technical capabilities: a new approach to address the office of environmental management cleanup challenges in the 21. century

    SciTech Connect

    Fiore, J.J.; Rizkalla, E.I.

    2007-07-01

    The United States Department of Energy (DOE), Office of Environmental Management (EM) is responsible for the nations nuclear weapons program legacy wastes cleanup. The EM cleanup efforts continue to progress, however the cleanup continues to be technologically complex, heavily regulated, long-term, and a high life cycle cost estimate (LCCE) effort. Over the past few years, the EM program has undergone several changes to accelerate its cleanup efforts with varying degrees of success. Several cleanup projects continued to experience schedule delays and cost growth. The schedule delays and cost growth have been attributed to several factors such as changes in technical scope, regulatory and safety considerations, inadequacy of acquisition approach and project management. This article will briefly review the background and schools of thought on strategic management and organizational change practiced in the United States over the last few decades to improve an organisation's competitive edge and cost performance. The article will briefly review examples such as the change at General Electric, and the recent experience obtained from the nuclear industry, namely the long-term response to the 1986 Chernobyl accident. The long-term response to Chernobyl, though not a case of organizational change, could provide some insight in the strategic management approaches used to address people issues. The article will discuss briefly EM attempts to accelerate cleanup over the past few years, and the subsequent paradigm shift. The paradigm shift targets enhancing and/or creating organizational capabilities to achieve cost savings. To improve its ability to address the 21. century environmental cleanup challenges and achieve cost savings, EM has initiated new corporate changes to develop new and enhance existing capabilities. These new and enhanced organizational capabilities include a renewed emphasis on basics, especially technical capabilities including safety, project management

  3. In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market

    PubMed Central

    Geris, L.; Guyot, Y.; Schrooten, J.; Papantoniou, I.

    2016-01-01

    The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as academic research institutes are in need of tools to advance their understanding and, at the same time, reduce their R&D costs, increase product quality and productivity, and reduce the time to market. An additional difficulty is the regulatory path that needs to be followed, which is challenging in the case of cell-based therapeutic products and should rely on the implementation of quality by design (QbD) principles. In silico modelling is a tool that allows the above-mentioned challenges to be addressed in the field of regenerative medicine. This review discusses such in silico models and focuses more specifically on the bioprocess. Three (clusters of) examples related to this subject are discussed. The first example comes from the pharmaceutical engineering field where QbD principles and their implementation through the use of in silico models are both a regulatory and economic necessity. The second example is related to the production of red blood cells. The described in silico model is mainly used to investigate the manufacturing process of the cell-therapeutic product, and pays special attention to the economic viability of the process. Finally, we describe the set-up of a model capturing essential events in the development of a tissue-engineered combination product in the context of bone tissue engineering. For each of the examples, a short introduction to some economic aspects is given, followed by a description of the in silico tool or tools that have been developed to allow the implementation of QbD principles and optimal design. PMID:27051516

  4. Biaxial tension of fibrous tissue: using finite element methods to address experimental challenges arising from boundary conditions and anisotropy.

    PubMed

    Jacobs, Nathan T; Cortes, Daniel H; Vresilovic, Edward J; Elliott, Dawn M

    2013-02-01

    Planar biaxial tension remains a critical loading modality for fibrous soft tissue and is widely used to characterize tissue mechanical response, evaluate treatments, develop constitutive formulas, and obtain material properties for use in finite element studies. Although the application of tension on all edges of the test specimen represents the in situ environment, there remains a need to address the interpretation of experimental results. Unlike uniaxial tension, in biaxial tension the applied forces at the loading clamps do not transmit fully to the region of interest (ROI), which may lead to improper material characterization if not accounted for. In this study, we reviewed the tensile biaxial literature over the last ten years, noting experimental and analysis challenges. In response to these challenges, we used finite element simulations to quantify load transmission from the clamps to the ROI in biaxial tension and to formulate a correction factor that can be used to determine ROI stresses. Additionally, the impact of sample geometry, material anisotropy, and tissue orientation on the correction factor were determined. Large stress concentrations were evident in both square and cruciform geometries and for all levels of anisotropy. In general, stress concentrations were greater for the square geometry than the cruciform geometry. For both square and cruciform geometries, materials with fibers aligned parallel to the loading axes reduced stress concentrations compared to the isotropic tissue, resulting in more of the applied load being transferred to the ROI. In contrast, fiber-reinforced specimens oriented such that the fibers aligned at an angle to the loading axes produced very large stress concentrations across the clamps and shielding in the ROI. A correction factor technique was introduced that can be used to calculate the stresses in the ROI from the measured experimental loads at the clamps. Application of a correction factor to experimental biaxial

  5. In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market.

    PubMed

    Geris, L; Guyot, Y; Schrooten, J; Papantoniou, I

    2016-04-01

    The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as academic research institutes are in need of tools to advance their understanding and, at the same time, reduce their R&D costs, increase product quality and productivity, and reduce the time to market. An additional difficulty is the regulatory path that needs to be followed, which is challenging in the case of cell-based therapeutic products and should rely on the implementation of quality by design (QbD) principles. In silico modelling is a tool that allows the above-mentioned challenges to be addressed in the field of regenerative medicine. This review discusses such in silico models and focuses more specifically on the bioprocess. Three (clusters of) examples related to this subject are discussed. The first example comes from the pharmaceutical engineering field where QbD principles and their implementation through the use of in silico models are both a regulatory and economic necessity. The second example is related to the production of red blood cells. The described in silico model is mainly used to investigate the manufacturing process of the cell-therapeutic product, and pays special attention to the economic viability of the process. Finally, we describe the set-up of a model capturing essential events in the development of a tissue-engineered combination product in the context of bone tissue engineering. For each of the examples, a short introduction to some economic aspects is given, followed by a description of the in silico tool or tools that have been developed to allow the implementation of QbD principles and optimal design. PMID:27051516

  6. Community challenges in biomedical text mining over 10 years: success, failure and the future.

    PubMed

    Huang, Chung-Chi; Lu, Zhiyong

    2016-01-01

    One effective way to improve the state of the art is through competitions. Following the success of the Critical Assessment of protein Structure Prediction (CASP) in bioinformatics research, a number of challenge evaluations have been organized by the text-mining research community to assess and advance natural language processing (NLP) research for biomedicine. In this article, we review the different community challenge evaluations held from 2002 to 2014 and their respective tasks. Furthermore, we examine these challenge tasks through their targeted problems in NLP research and biomedical applications, respectively. Next, we describe the general workflow of organizing a Biomedical NLP (BioNLP) challenge and involved stakeholders (task organizers, task data producers, task participants and end users). Finally, we summarize the impact and contributions by taking into account different BioNLP challenges as a whole, followed by a discussion of their limitations and difficulties. We conclude with future trends in BioNLP challenge evaluations. PMID:25935162

  7. Addressing Methodological Challenges in Large Communication Datasets: Collecting and Coding Longitudinal Interactions in Home Hospice Cancer Care

    PubMed Central

    Reblin, Maija; Clayton, Margaret F; John, Kevin K; Ellington, Lee

    2015-01-01

    In this paper, we present strategies for collecting and coding a large longitudinal communication dataset collected across multiple sites, consisting of over 2000 hours of digital audio recordings from approximately 300 families. We describe our methods within the context of implementing a large-scale study of communication during cancer home hospice nurse visits, but this procedure could be adapted to communication datasets across a wide variety of settings. This research is the first study designed to capture home hospice nurse-caregiver communication, a highly understudied location and type of communication event. We present a detailed example protocol encompassing data collection in the home environment, large-scale, multi-site secure data management, the development of theoretically-based communication coding, and strategies for preventing coder drift and ensuring reliability of analyses. Although each of these challenges have the potential to undermine the utility of the data, reliability between coders is often the only issue consistently reported and addressed in the literature. Overall, our approach demonstrates rigor and provides a “how-to” example for managing large, digitally-recorded data sets from collection through analysis. These strategies can inform other large-scale health communication research. PMID:26580414

  8. Addressing Methodological Challenges in Large Communication Data Sets: Collecting and Coding Longitudinal Interactions in Home Hospice Cancer Care.

    PubMed

    Reblin, Maija; Clayton, Margaret F; John, Kevin K; Ellington, Lee

    2016-07-01

    In this article, we present strategies for collecting and coding a large longitudinal communication data set collected across multiple sites, consisting of more than 2000 hours of digital audio recordings from approximately 300 families. We describe our methods within the context of implementing a large-scale study of communication during cancer home hospice nurse visits, but this procedure could be adapted to communication data sets across a wide variety of settings. This research is the first study designed to capture home hospice nurse-caregiver communication, a highly understudied location and type of communication event. We present a detailed example protocol encompassing data collection in the home environment, large-scale, multisite secure data management, the development of theoretically-based communication coding, and strategies for preventing coder drift and ensuring reliability of analyses. Although each of these challenges has the potential to undermine the utility of the data, reliability between coders is often the only issue consistently reported and addressed in the literature. Overall, our approach demonstrates rigor and provides a "how-to" example for managing large, digitally recorded data sets from collection through analysis. These strategies can inform other large-scale health communication research. PMID:26580414

  9. A holistic, multi-scale dynamic downscaling framework for climate impact assessments and challenges of addressing finer-scale watershed dynamics

    NASA Astrophysics Data System (ADS)

    Kim, Jongho; Ivanov, Valeriy Y.

    2015-03-01

    We present a state-of-the-art holistic, multi-scale dynamic downscaling approach suited to address climate change impacts on hydrologic metrics and hydraulic regime of surface flow at the "scale of human decisions" in ungauged basins. The framework rests on stochastic and physical downscaling techniques that permit one-way crossing 106-100 m scales, with a specific emphasis on 'nesting' hydraulic assessments within a coarser-scale hydrologic model. Future climate projections for the location of Manchester watershed (MI) are obtained from an ensemble of General Circulation Models of the 3rd phase of the Coupled Model Intercomparison Project database and downscaled to a "point" scale using a weather generator. To represent the natural variability of historic and future climates, we generated continuous time series of 300 years for the locations of 3 meteorological stations located in the vicinity of the ungauged basin. To make such a multi-scale approach computationally feasible, we identified the months of May and August as the periods of specific interest based on ecohydrologic considerations. Analyses of historic and future simulation results for the identified periods show that the same median rainfall obtained by accounting for climate natural variability triggers hydrologically-mediated non-uniqueness in flow variables resolved at the hydraulic scale. An emerging challenge is that uncertainty initiated at the hydrologic scale is not necessarily preserved at smaller-scale flow variables, because of non-linearity of underlying physical processes, which ultimately can mask climate uncertainty. We stress the necessity of augmenting climate-level uncertainties of emission scenario, multi-model, and natural variability with uncertainties arising due to non-linearities in smaller-scale processes.

  10. Challenging future, challenging past: the relationship of social integration and psychological impairment in traumatized refugees

    PubMed Central

    Schick, Matthis; Zumwald, Andre; Knöpfli, Bina; Nickerson, Angela; Bryant, Richard A.; Schnyder, Ulrich; Müller, Julia; Morina, Naser

    2016-01-01

    Background Refugees have been shown to present high prevalence rates of trauma-related mental disorders. Despite their psychological impairment, they are expected to meet high functional requirements in terms of social integration into, and financial independence from, the host society. Methods This cross-sectional study examined the relationship of mental health problems, post-migration living difficulties (PMLD), and social integration in a sample of 104 refugees seeking treatment for severe posttraumatic stress and comorbid symptoms in two outpatient clinics in Switzerland. Results Despite an average time of residence in Switzerland of over 10 years, participants showed poor integration and a high number of PMLD. Integration difficulties were closely associated with psychological symptoms, but not with socio-demographic parameters such as education or visa status. Conclusions Psychological impairment in treatment-seeking traumatized refugees is associated with poor integration. To foster social integration, it is crucial to better understand and address the specific needs of this highly vulnerable population. PMID:26886484

  11. The Future of Teaching and Learning: Challenging Standards and High Expectations. Satellite Town Meeting #73. [Videotape].

    ERIC Educational Resources Information Center

    Chamber of Commerce of the United States, Washington, DC.

    This 60-minute VHS videotape of a U.S. Department of Education Satellite Town Meeting focuses on the future of learning in U.S. schools and what it will take to create challenging, exciting, high performing schools. It explains that there cannot be excellent learning without excellent teaching. The 1985 National Teacher of the Year co-hosts this…

  12. The Web's Impact on Social Work Education: Opportunities, Challenges, and Future Directions.

    ERIC Educational Resources Information Center

    Sandell, Karen S.; Hayes, Sherman

    2002-01-01

    Examines the ways in which social work educators who are interested in Web technology but not expert in its applications can use the World Wide Web. Current opportunities and challenges in integrating technology into social work education are discussed, and future directions in the use of technology are explored. (EV)

  13. Wavelet image processing applied to optical and digital holography: past achievements and future challenges

    NASA Astrophysics Data System (ADS)

    Jones, Katharine J.

    2005-08-01

    The link between wavelets and optics goes back to the work of Dennis Gabor who both invented holography and developed Gabor decompositions. Holography involves 3-D images. Gabor decompositions involves 1-D signals. Gabor decompositions are the predecessors of wavelets. Wavelet image processing of holography, both optical holography and digital holography, will be examined with respect to past achievements and future challenges.

  14. Future Challenges in Higher Education--Bologna Experts' Community Case Study

    ERIC Educational Resources Information Center

    Yemini, Miri

    2012-01-01

    This work presents results from systematic analysis of the challenges for the future of higher education in European and neighboring countries as it was extracted from the Bologna experts and Higher Education Reform experts' opinions. Opinions of more than 100 experts from 35 countries were documented and analyzed. Significant differences in the…

  15. Hitting the Moving Target: Challenges of Creating a Dynamic Curriculum Addressing the Ethical Dimensions of Geospatial Data

    ERIC Educational Resources Information Center

    Carr, John; Vallor, Shannon; Freundschuh, Scott; Gannon, William L.; Zandbergen, Paul

    2014-01-01

    While established ethical norms and core legal principles concerning the protection of privacy may be easily identified, applying these standards to rapidly evolving digital information technologies, markets for digital information and convulsive changes in social understandings of privacy is increasingly challenging. This challenge has been…

  16. Scholarship in Academic Surgery: History, Challenges, and Ideas for the Future

    PubMed Central

    Stein, Sharon L.

    2013-01-01

    The role of academic surgery is changing. Traditional roles of the triple threat researcher, clinician and teacher, were formulated by Osler and improved upon by Boyle in the 1990s. These include application and integration of research to clinical problems. However, new pressures exist on the academic surgeon. Financial pressures rising costs of health care and decreased research funding all need to be addressed. In addition, retention and advancement of faculty is more difficult with increased emphasis of clinical practice in academic medicine. The future of academic medicine will require personal optimization as a multifaceted academician, businessman, and administrator, as well as rethinking how academic medicine may function in the future. PMID:24436678

  17. Top 10 Ways To Improve Public Schools. Innovative Solutions To Help Address the Issues and Challenges Facing Most Public School Districts.

    ERIC Educational Resources Information Center

    Texas State Comptroller of Public Accounts, Austin.

    This report offers the top 10 challenges identified by public schools and the ways that the Texas School Performance Review (TSPR) suggests that these issues be addressed. The TSPR ensures that scarce education resources are spent in the classroom. For a TSPR review, the TSPR team is invited in for months of detailed study, during which it asks…

  18. Reaching Each Student: National Challenge and Organizational Commitment. Addresses to the College Board National Forum, October 31-November 2, 1990, Boston, Massachusetts.

    ERIC Educational Resources Information Center

    College Board, New York, NY.

    Four speakers addressed the College Board National Forum on "Reaching Each Student" in the Fall of 1990 in Boston, Massachusetts. John F. Akers, Chairman of the Board at International Business Machines in his speech "Reaching Each Student: A Business Perspective" challenged the College Board to work with American business to change the educational…

  19. Preparing Early Childhood Educators to Address Young Children's Social-Emotional Development and Challenging Behavior: A Survey of Higher Education Programs in Nine States

    ERIC Educational Resources Information Center

    Hemmeter, Mary Louise; Santos, Rosa Milagros; Ostrosky, Michaelene M.

    2008-01-01

    This article presents results from a survey of faculty members from 2- and 4-year higher education programs in nine states that prepare teachers to work with preschool children. The purpose of the study was to determine how professors address content related to social-emotional development and challenging behaviors, how well prepared they believe…

  20. Endovascular Interventions in Acute Ischemic Stroke: Recent Evidence, Current Challenges, and Future Prospects.

    PubMed

    Appireddy, Ramana; Zerna, Charlotte; Menon, Bijoy K; Goyal, Mayank

    2016-07-01

    After many years of clinical research, endovascular thrombectomy has been conclusively proven to be an effective treatment in acute ischemic stroke. The evidence is compelling; however, it is generated in high volume stroke centers with stroke expertise. Challenges remain ahead on translating and implementing this evidence in routine clinical care across the world. The current evidence has opened up avenues for further research and innovation in this field. In this review, we will discuss the evolution of evidence on endovascular thrombectomy followed by a discussion of challenges and future prospects in this exciting field of stroke care. PMID:27221502