Science.gov

Sample records for address regulatory issues

  1. Addressing Social Issues.

    ERIC Educational Resources Information Center

    Schoebel, Susan

    1991-01-01

    Maintains that advertising can help people become more aware of social responsibilities. Describes a successful nationwide newspaper advertising competition for college students in which ads address social issues such as literacy, drugs, teen suicide, and teen pregnancy. Notes how the ads have helped grassroots programs throughout the United…

  2. Addressing Student Life Issues.

    ERIC Educational Resources Information Center

    Kolvitz, Marcia, Ed.

    These two conference papers from the Biennial Conference on Postsecondary Education for Persons who are Deaf or Hard of Hearing focus on campus life issues for individuals with deafness or hard of hearing. The first paper, "A Customized Residence Hall Experience for Students Who Are Deaf or Hard of Hearing" (Nancy Kasinski and others), describes…

  3. Addressing Transgender Issues in Schools

    ERIC Educational Resources Information Center

    Cavanagh, Marian

    2016-01-01

    As mainstream media focus more attention on transgender issues, and as anti-discrimination laws evolve, a shift is taking place on campuses. Many schools now include gender identity and expression in their inclusivity work and seek to establish policies and procedures to support transgender students and their families. It's not an easy task. In…

  4. Federal Offices That Address Women's Issues.

    ERIC Educational Resources Information Center

    Weber, Patricia A.; And Others

    This directory contains a listing of federal offices that address women's issues. Among the departments and agencies included are: the executive branch and the executive agencies departments of agriculture, commerce, defense (Air Force, Army, Coast Guard, Marine Corps, National Guard and Navy), education, health and human services, housing and…

  5. Addressing Issues Related to Technology and Engineering

    ERIC Educational Resources Information Center

    Technology Teacher, 2008

    2008-01-01

    This article presents an interview with Michael Hacker and David Burghardt, codirectors of Hoftra University's Center for Technological Literacy. Hacker and Burghardt address issues related to technology and engineering. They argue that teachers need to be aware of the problems kids are facing, and how to present these problems in an engaging…

  6. Versions to Address Business Process Flexibility Issue

    NASA Astrophysics Data System (ADS)

    Chaâbane, Mohamed Amine; Andonoff, Eric; Bouaziz, Rafik; Bouzguenda, Lotfi

    This paper contributes to address an important issue in business process management: the Business Process (BP) flexibility issue. First, it defends that versions are an interesting solution to deal with both a priori (when designing BPs) and a posteriori (when executing BPs) flexibility. It also explains why previous contributions about versions of BPs are incomplete, and need to be revisited. Then, the paper presents a meta-model for BP versions, which combines five perspectives -the functional, process, informational, organizational and operation perspectives- for BP modelling, and which allows a comprehensive description of versionalized BPs.

  7. Recent NRC research activities addressing valve and pump issues

    SciTech Connect

    Morrison, D.L.

    1996-12-01

    The mission of the U.S. Nuclear Regulatory Commission (NRC) is to ensure the safe design, construction, and operation of commercial nuclear power plants and other facilities in the U.S.A. One of the main roles that the Office of Nuclear Regulatory Research (RES) plays in achieving the NRC mission is to plan, recommend, and implement research programs that address safety and technical issues deemed important by the NRC. The results of the research activities provide the bases for developing NRC positions or decisions on these issues. Also, RES performs confirmatory research for developing the basis to evaluate industry responses and positions on various regulatory requirements. This presentation summarizes some recent RES supported research activities that have addressed safety and technical issues related to valves and pumps. These activities include the efforts on determining valve and motor-operator responses under dynamic loads and pressure locking events, evaluation of monitoring equipment, and methods for detecting and trending aging of check valves and pumps. The role that RES is expected to play in future years to fulfill the NRC mission is also discussed.

  8. Rational Rhymes for Addressing Common Childhood Issues

    ERIC Educational Resources Information Center

    Warren, Jeffrey M.

    2011-01-01

    Music-based interventions are valuable tools counselors can use when working with children. Specific types of music-based interventions, such as songs or rhymes, can be especially pertinent in addressing the thoughts, feelings, and behaviors of children. Rational-emotive behavior therapy (REBT) provides a therapeutic framework that encourages…

  9. Religious Diversity in Schools: Addressing the Issues

    ERIC Educational Resources Information Center

    Whittaker, Catharine R.; Salend, Spencer; Elhoweris, Hala

    2009-01-01

    The vignettes presented in this article indicate that today's schools are made up of diverse groups of students including those from a variety of religious and spiritual backgrounds. Students feel safe and are better able to learn when issues of diversity are handled with sensitivity. This article provides guidelines and strategies for helping…

  10. Detecting and addressing adolescent issues and concerns

    PubMed Central

    Lewin, Warren; Knäuper, Bärbel; Roseman, Michelle; Adler, Perry; Malus, Michael

    2009-01-01

    ABSTRACT OBJECTIVE To assess the efficacy of a previsit questionnaire (PVQ), implemented without formal training, that was designed to screen for biomedical and psychosocial health issues and concerns among adolescent patients in a hospital-based primary care clinic, and to examine the subsequent action taken for health issues and concerns identified with the PVQ. DESIGN Retrospective review of adolescent medical charts, using a pre-post design. SETTING An outpatient primary care clinic located in an urban teaching hospital in Montreal, Que. PARTICIPANTS A total of 210 adolescent patients aged 13 to 19 who visited the clinic between 2000 and 2004. MAIN OUTCOME MEASURES The type (medical vs psychosocial) and number of issues detected and actions taken by physicians in one-to-one consultations with adolescent patients 2 years before (2000–2002) and 2 years after (2002–2004) PVQ implementation, as noted in the patients’ medical charts. RESULTS In total, 105 charts were reviewed for each group. An increase in the number of psychosocial issues was detected following the introduction of the PVQ. An increase in the frequency of action taken for psychosocial concerns and a decrease in the frequency of medical action taken by physicians were found after PVQ implementation. More notations related to psychosocial concerns were also found in the adolescents’ charts after introduction of the PVQ. CONCLUSION A PVQ is an effective strategy to improve adolescent screening for psychosocial issues and concerns. Implementing such a questionnaire requires no training and can therefore be easily incorporated into clinical practice. PMID:19602665

  11. Regulatory evaluation and acceptance issues for phytotechnology projects.

    PubMed

    Flechas, Felix W; Latady, Marisa

    2003-01-01

    The use of plant based systems in hazardous waste management or site clean up is growing at a rapid rate. Major hurdles to implementation will be encountered by proponents if essential regulatory policies and regulations are not understood or addressed early in the project development. Understanding the regulatory requirements or issues as they relate to innovative clean up approaches such as phytotechnologies are critical to the successful implementation and long-term monitoring of these technologies. This chapter will address the issues that regulators may have in applying phytotechnologies to site conditions or contaminants, designing phytoremediation projects, monitoring or maintaining the systems for the long-term, establishing performance criteria, and demonstrating achievement of performance goals. PMID:12674403

  12. Software programs that address site-specific inventory characteristics issues.

    SciTech Connect

    Dare, J. H.; Cournoyer, M. E.

    2001-01-01

    The proper characterization of Hazardous, Mixed Low-Level, and Mixed Transuranic waste enhances productivity and safety. Hazardous material criteria that need to be considered include physical and health hazards inherent to the waste stream. Other factors that may influence characterization include: particulate diameter, complexing or chelating agent properties, lead, and mercury content, pressurized containers, and P-listed wastes. To meet these requirements are only a simple matter of generating a database with the proper fields. Manufactures and institutional databases bank huge sources of information, such as, work control documents, substance identification, container types, components of mixtures, physical property data, and regulatory data. In this report, utilization of commercially available software programs to take advantage of these resources in addressing waste characterization issues are presented. The application of user-friendly programs eliminates part of the tediousness associated with the complex requirements of certifying to general waste acceptance criteria with minimal impact on programmatic work. In other words, tapping into manufacturer and institutional database provides a way to take advantage of the combined expertise of these resources in managing a cost effective waste certification program as well as adding a quality assurance element to the program.

  13. Addressing Physical and Emotional Issues in Children's Literature

    ERIC Educational Resources Information Center

    Johnson, Jonathon

    2010-01-01

    The purpose of this paper is to examine how physical and mental disabilities are addressed in children's literature. Many authors are able to integrate the issues into their work in a way that enhances the story and benefits the reader. As young readers learn about the issues and struggles faced by children with mental and physical disabilities,…

  14. Regulatory approaches for addressing dissolved oxygen concerns at hydropower facilities

    SciTech Connect

    Peterson, Mark J.; Cada, Glenn F.; Sale, Michael J.; Eddlemon, Gerald K.

    2003-03-01

    Low dissolved oxygen (DO) concentrations are a common water quality problem downstream of hydropower facilities. At some facilities, structural improvements (e.g. installation of weir dams or aerating turbines) or operational changes (e.g., spilling water over the dam) can be made to improve DO levels. In other cases, structural and operational approaches are too costly for the project to implement or are likely to be of limited effectiveness. Despite improvements in overall water quality below dams in recent years, many hydropower projects are unable to meet state water quality standards for DO. Regulatory agencies in the U.S. are considering or implementing dramatic changes in their approach to protecting the quality of the Nation’s waters. New policies and initiatives have emphasized flexibility, increased collaboration and shared responsibility among all parties, and market-based, economic incentives. The use of new regulatory approaches may now be a viable option for addressing the DO problem at some hydropower facilities. This report summarizes some of the regulatory-related options available to hydropower projects, including negotiation of site-specific water quality criteria, use of biological monitoring, watershed-based strategies for the management of water quality, and watershed-based trading. Key decision points center on the health of the local biological communities and whether there are contributing impacts (i.e., other sources of low DO effluents) in the watershed. If the biological communities downstream of the hydropower project are healthy, negotiation for site-specific water quality standards or biocriteria (discharge performance criteria based on characteristics of the aquatic biota) might be pursued. If there are other effluent dischargers in the watershed that contribute to low DO problems, watershed-scale strategies and effluent trading may be effective. This report examines the value of regulatory approaches by reviewing their use in

  15. Summary Report Panel 2: Regulatory Issues.

    PubMed

    Johnson, Craig; Dolman, Sarah

    2016-01-01

    The Effects of Noise on Aquatic Life 2013 Conference convened four panels to discuss specific topics related to the effects of anthropogenic noise on aquatic ecosystems. The second of these four panels, the Regulatory Issues Panel, brought together several different perspectives: representatives of agencies responsible for regulating activities that introduce anthropogenic noise into aquatic ecosystems: representatives of the regulated industries, agencies, and consultancies that advise regulators and regulated industries; and nongovernmental organizations and other stakeholders with an interest in anthropogenic noise. The goal of the panel was to help develop a more productive relationship between these groups. PMID:26611097

  16. Effective Organizational Structures and Processes: Addressing Issues of Change

    ERIC Educational Resources Information Center

    Andrade, Maureen Snow

    2016-01-01

    This chapter describes organizational structures and processes at the institutional and project levels for the development and support of distance learning initiatives. It addresses environmental and stakeholder issues and explores principles and strategies of effective leadership for change creation and management.

  17. Addressing the Developmental Issues of Lesbian and Gay College Students.

    ERIC Educational Resources Information Center

    Marso, Joan L.

    This paper addresses the developmental stages and issues faced by lesbian and gay college students between the ages of 18 and 25. Over and above the developmental stages faced by all students, lesbian and gay students frequently struggle with their sexual identity and development and the range of problems and emotions associated with coming to…

  18. Family Connections: Addressing Behavior Issues--Practical Tips for Parents

    ERIC Educational Resources Information Center

    LaCaze, Donna; Kirylo, James D.

    2012-01-01

    When parents get together, the subject of appropriately addressing the behavior of their children often comes to the forefront of conversations. Parents share various challenges they face with their children, including issues associated with listening, eating vegetables, doing chores, and a host of other discipline-related situations. The plethora…

  19. Addressing Consent Issues in Donation After Circulatory Determination of Death.

    PubMed

    Overby, Kim J; Weinstein, Michael S; Fiester, Autumn

    2015-01-01

    Given the widening gap between the number of individuals on transplant waiting lists and the availability of donated organs, as well as the recent plateau in donations based on neurological criteria (i.e., brain death), there has been a growing interest in expanding donation after circulatory determination of death. While the prevalence of this form of organ donation continues to increase, many thorny ethical issues remain, often creating moral distress in both clinicians and families. In this article, we address one of these issues, namely, the challenges surrounding patient and surrogate informed consent for donation after circulatory determination of death. First we discuss several general concerns regarding consent related to this form of organ donation, and then we address additional issues that are unique to three different patient categories: adult patients with medical decision-making capacity or potential capacity, adult patients who lack capacity, and pediatric patients. PMID:26225503

  20. Adequacy of human reliability data for addressing risk reduction issues at commercial nuclear power plants

    SciTech Connect

    Ryan, T.G.; O'Brien, J.N.; Spettell, C.M.

    1985-01-01

    This paper describes the results of an assessment of how well currently available Probabilistic Risk Assessment (PRA) data address a representative set of human risk issues of current concern to the US Nuclear Regulatory Commission (NRC). A three-step process was used to make that assessment. First, all Human Reliability Analysis (HRA) data included in 19 PRAs were identified, collected, and stored on a computer. Second, a list of human risk ''working level issues'' of concern to NRC was compiled. Finally, the HRA/PRA data which were collected from 19 PRAs were compared to the data needs to assess the extent to which currently available PRA data are useful in addressing human risk issues of concern to NRC. Less than 1% of the data needs were determined to be addressed by currently available PRA data. Findings indicate that PRA data could be far more useful in addressing human risk issues with modification of the development process and documentation structure of PRAs. In addition, information from non-PRA sources could be integrated with PRA data to address many other issues. 7 refs., 13 tabs.

  1. Extending the ARS Experimental Watersheds to Address Regional Issues

    NASA Astrophysics Data System (ADS)

    Marks, D.; Goodrich, D. C.; Winstral, A.; Bosch, D. D.; Pool, D.

    2001-12-01

    The USDA-Agricultural Research Service's (ARS) Watershed Research Program maintains and operates a diverse, geog raphically distributed, nested, multi-scale, national ex perimental watershed network. This network, much of which has been operational for more than 40 years (several more than 60 years), constitutes one the best networks of its kind in the world. The watershed network and its instrumentation was primarily established to assess the hydrologic impacts of watershed conservation and management practices. It has evolved, through development of long-term hydrologic data, as a network of high quality outdoor laboratories for addressing emerging science issues facing hydrologists and resource managers. While the value of the experimental watershed for investigating precipitation, climatic, and hydrologic processes is unquestioned, extending the results from these investigations to other sites and larger areas is more difficult. ARS experimental watersheds are a few hundred km2 or smaller making it challenging to address regional scale issues. To address this the ARS watershed program is, with a suite of partners from universities and other federal agencies, enlarging its research focus to extend beyond the boundaries of the experimental watershed. In this poster we present several examples of this effort, with suggestions on how, using the experimental watershed and its core, a larger scale hydrologic observatory could be developed and maintained.

  2. Introduction: the need to address older women's mental health issues.

    PubMed

    Malatesta, Victor J

    2007-01-01

    Women are the primary consumers of mental health services. Ironically, research addressing their unique needs lags behind that of men's issues. The aging process introduces an important variable that accentuates the relative lack of information and specific treatment guidelines for older women who are confronted by mental health problems. This volume offers a comprehensive overview for the health professional who is seeking a greater depth of understanding with respect to the study of mental health problems in general, and how these issues pertain specifically to women and the aging process. A second goal of this project is to provide the practicing therapist and counselor with a research update and a broad clinical perspective offered by seasoned clinicians. Using current psychiatric diagnosis as a framework, the contributions address the range of mental health problems, including dementia and cognitive impairment, schizophrenia, alcohol abuse, mood and anxiety disorders, traumatic and dissociative conditions, sexual and eating disorders, and personality disorders. It is hoped that this book will inform, inspire and encourage students and health professionals in their work with middle aged and older women who are facing mental health challenges. PMID:17588876

  3. Exploring the ethical and regulatory issues in pragmatic clinical trials.

    PubMed

    Califf, Robert M; Sugarman, Jeremy

    2015-10-01

    The need for high-quality evidence to support decision making about health and health care by patients, physicians, care providers, and policy-makers is well documented. However, serious shortcomings in evidence persist. Pragmatic clinical trials that use novel techniques including emerging information and communication technologies to explore important research questions rapidly and at a fraction of the cost incurred by more "traditional" research methods promise to help close this gap. Nevertheless, while pragmatic clinical trials can bridge clinical practice and research, they may also raise difficult ethical and regulatory challenges. In this article, the authors briefly survey the current state of evidence that is available to inform clinical care and other health-related decisions and discuss the potential for pragmatic clinical trials to improve this state of affairs. They then propose a new working definition for pragmatic research that centers upon fitness for informing decisions about health and health care. Finally, they introduce a project, jointly undertaken by the National Institutes of Health Health Care Systems Research Collaboratory and the National Patient-Centered Clinical Research Network (PCORnet), which addresses 11 key aspects of current systems for regulatory and ethical oversight of clinical research that pose challenges to conducting pragmatic clinical trials. In the series of articles commissioned on this topic published in this issue of Clinical Trials, each of these aspects is addressed in a dedicated article, with a special focus on the interplay between ethical and regulatory considerations and pragmatic clinical research aimed at informing "real-world" choices about health and health care. PMID:26374676

  4. Western Wind Strategy: Addressing Critical Issues for Wind Deployment

    SciTech Connect

    Douglas Larson; Thomas Carr

    2012-03-30

    The goal of the Western Wind Strategy project was to help remove critical barriers to wind development in the Western Interconnection. The four stated objectives of this project were to: (1) identify the barriers, particularly barriers to the operational integration of renewables and barriers identified by load-serving entities (LSEs) that will be buying wind generation, (2) communicate the barriers to state officials, (3) create a collaborative process to address those barriers with the Western states, utilities and the renewable industry, and (4) provide a role model for other regions. The project has been on the forefront of identifying and informing state policy makers and utility regulators of critical issues related to wind energy and the integration of variable generation. The project has been a critical component in the efforts of states to push forward important reforms and innovations that will enable states to meet their renewable energy goals and lower the cost to consumers of integrating variable generation.

  5. Legal and regulatory issues affecting compressed air energy storage

    SciTech Connect

    Hendrickson, P.L.

    1981-07-01

    Several regulatory and legal issues that can potentially affect implementation of a compressed air energy storage (CAES) system are discussed. This technology involves the compression of air using base load electric power for storage in an underground storage medium. The air is subsequently released and allowed to pass through a turbine to generate electricity during periods of peak demand. The storage media considered most feasible are a mined hard rock cavern, a solution-mined cavern in a salt deposit, and a porous geologic formation (normally an aquifer) of suitable structure. The issues are discussed in four categories: regulatory issues common to most CAES facilities regardless of storage medium, regulatory issues applicable to particular CAES reservoir media, issues related to possible liability from CAES operations, and issues related to acquisition of appropriate property rights for CAES implementation. The focus is on selected federal regulation. Lesser attention is given to state and local regulation. (WHK)

  6. Legal and regulatory issues affecting aquifer thermal energy storage

    SciTech Connect

    Hendrickson, P.L.

    1981-10-01

    This document updates and expands the report with a similar title issued in October 1980. This document examines a number of legal and regulatory issues that potentially can affect implementation of the aquifer thermal energy storage (ATES) concept. This concept involves the storage of thermal energy in an underground aquifer until a later date when it can be effectively utilized. Either heat energy or chill can be stored. Potential end uses of the energy include district space heating and cooling, industrial process applications, and use in agriculture or aquaculture. Issues are examined in four categories: regulatory requirements, property rights, potential liability, and issues related to heat or chill delivery.

  7. Addressing security issues related to virtual institute distributed activities

    NASA Astrophysics Data System (ADS)

    Stytz, Martin R.; Banks, Sheila B.

    2008-03-01

    One issue confounding the development and experimentation of distributed modeling and simulation environments is the inability of the project team to identify and collaborate with resources, both human and technical, from outside the United States. This limitation is especially significant within the human behavior representation area where areas such as cultural effects research and joint command team behavior modeling require the participation of various cultural and national representatives. To address this limitation, as well as other human behavior representation research issues, NATO Research and Technology Organization initiated a project to develop a NATO virtual institute that enables more effective and more collaborative research into human behavior representation. However, in building and operating a virtual institute one of the chief concerns must be the cyber security of the institute. Because the institute "exists" in cyberspace, all of its activities are susceptible to cyberattacks, subterfuge, denial of service and all of the vulnerabilities that networked computers must face. In our opinion, for the concept of virtual institutes to be successful and useful, their operations and services must be protected from the threats in the cyber environment. A key to developing the required protection is the development and promulgation of standards for cyber security. In this paper, we discuss the types of cyber standards that are required, how new internet technologies can be exploited and can benefit the promulgation, development, maintenance, and robustness of the standards. This paper is organized as follows. Section One introduces the concept of the virtual institutes, the expected benefits, and the motivation for our research and for research in this area. Section Two presents background material and a discussion of topics related to VIs, uman behavior and cultural modeling, and network-centric warfare. Section Three contains a discussion of the

  8. Air toxics regulatory issues facing urban settings.

    PubMed Central

    Olden, K; Guthrie, J

    1996-01-01

    Biomarker research does not exist in isolation. Its usefulness can only be realized when it is translated into prevention strategies to protect public health. In the context of air toxics, these prevention strategies begin with the development of regulatory standards derived from risk assessment schemes. The Clean Air Act Amendments of 1990 list 189 air toxics, including many volatile organics, metals, and pesticides. The National Institute of Environmental Health Sciences (NIEHS), through its affiliation with the National Toxicology Program, has generated toxicity and carcinogenicity data on more than 100 of these air toxics. The NIEHS extramural and intramural research portfolios support a variety of projects that develop and validate biomarkers for use in environmental health science and risk assessment. Biomarkers have a tremendous potential in the areas of regulating air toxics and protecting public health. Risk assessors need data provided by biomarkers of exposure, biomarkers of dose/pharmacokinetics, biomarkers of susceptibility or individual variability, and biomarkers of effects. The greatest benefit would be realized if biomarkers could be employed in four areas of primary and secondary prevention. The first is the use of biomarkers to enhance extrapolation of animal data to human exposure situations in establishing risk standards. The second is the use of biomarkers that assess noncancer, as well as cancer, end points. Important health end points include pulmonary dysfunction, immunotoxicity, and neurotoxicity. Third, biomarkers that serve as early waming signs to detect intermediate effects would enhance our ability to design timely and cost-effective intervention strategies. Finally, biomarkers used to evaluate the effectiveness of intervention strategies, both in clinical and regulatory settings, would enable us to ensure that programs designed to protect public health do, in fact, achieve the desired outcome. PMID:8933026

  9. Issues in mass spectrometry between bench chemists and regulatory laboratory managers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    At the 123rd AOAC Annual Meeting in Philadelphia, 45 residue chemists gathered for a roundtable discussion of mass spectrometry (MS) for regulatory purposes involving chemical residues analysis. The session was conceived to address current technical and communication issues about MS between “bench ...

  10. US domestic and international regulatory issues

    NASA Technical Reports Server (NTRS)

    Levin, Lon C.; Nash, Dennis C.

    1993-01-01

    The U.S. domestic and international regulatory and policy milestones since 1982, when NASA filed its petition with the Federal Communications Commission (FCC) to establish the U.S. domestic Mobile Satellite Service (MSS), are described. In 1985, the FCC proposed to establish MSS services and allocate spectrum for such service. In 1986, the FCC allocated L-band spectrum for MSS. In 1987, at the Mobile World Administrative Radio Conference (MOB WARC-87), despite U.S., Canadian, and Mexican efforts, the WARC did not adopt a multi-service, generic MSS allocation. In 1989, the FCC licensed the first MSS system. After two decisions by the U.S. Court of Appeals, the FCC's licensing actions remain intact. The FCC also has permitted Comsat to provide international aeronautical and land MSS via the Inmarsat system. Inmarsat, however, may not serve the domestic U.S. market. In 1991, the FCC accepted applications for MSS systems, most of which were non-geostationary proposals, for operation in the Radiodetermination Satellite Service (RDSS) bands, and the VHF and UHF bands. In 1992, the FCC proposed rules for non-geostationary MSS systems and applied a negotiated rulemaking procedure to each. Also in 1992, the U.S. position for flexibility in existing MSS bands and for additional worldwide MSS allocations was adopted in large part at the 1992 World Administrative Radio Conference (WARC-92).

  11. In search of the silver bullet: regulatory models to address childhood obesity.

    PubMed

    Rothenberg, Joan R

    2010-01-01

    The concern over obesity today has evolved beyond an issue of personal vanity to a serious national health issue affecting millions of Americans. Obesity in children is especially alarming. Overweight children and adolescents are at risk for health problems throughout their lives. While under-nutrition or diet insufficiencies were once major obstacles in the development of healthy infants and children, the epidemic of childhood obesity marks the start of the 21st century with equally menacing health consequences. Childhood obesity creates an increased burden of disease on our economy with increased indirect economic costs of time lost from work for parents and time lost from school for the child. Data raise the possibility that the current generation of children could suffer greater illness or experience a shorter lifespan than that of their parents. Some experts believe that government mandated restrictions on dietary choices would alleviate the obesity problem, while others find such actions to be an unwarranted government intrusion. Still, as concerns about obesity continue to grow, especially regarding children, some say government intervention of some type is necessary to solve the problem. This paper examines the history and factors involved in the childhood obesity epidemic, explores regulatory options for its resolution, and provides an overview of obesity as a serious challenge to public health, and the health of children in particular. The federal agencies who share the responsibility for regulating food in the United States and their efforts to address the obesity problem are discussed as a background to various state and federal regulatory models influencing dietary choices. The effectiveness of proposed regulations and alternatives to government intervention suggest that the resolution of the childhood obesity issue requires a coordinated, multilevel approach. PMID:24475539

  12. Legislative and regulatory issues related to reusable launch systems

    NASA Astrophysics Data System (ADS)

    Peinemann, Manfred K. A.

    1996-03-01

    The development of reusable launch systems with private investment funds for primarily commercial launch services raises a number of novel legal and regulatory issues. The issues discussed include requirements for a whole new spectrum of safety and environmental issues; new certification rules, procedures and oversight organizations; liability and jurisdiction definitions, taxation treatments; government commitments and/or participation in commercial enterprises; and international legal and business issues. The satisfactory solution to all of these issues is a necessary condition for the development and operation of reusable launch vehicles to be a viable commercial enterprise.

  13. NARUC winter meetings address key issues for utility industry

    SciTech Connect

    Rodgers, L.M.

    1990-04-12

    This article reports on the National Association of Regulatory Utility Commissioners (NARUC) meeting of February, 1990. The topics covered by the report include acid rain (including emissions trading), electric and magnetic fields (as air pollution), energy conservation (including a call for increased funding of research, development and commercialization of energy conservation and renewable energy technologies), natural gas, and telecommunications.

  14. Abandoning pipelines working group regulatory issues

    SciTech Connect

    1997-03-01

    The history of hydrocarbon development in Louisiana and off its coast is one of the interdependence of technological innovation, entrepreneurial risk-taking, resource management, judicial decisions, legislation, marketing, employee good will, infrastructure and support services, coupled with favorable geologic structures that made early exploration and development relatively easy. Mariners sailing off the coast of Louisiana and Texas in the 1600`s recorded one of the earliest known natural oil seeps. They shrugged it off as unimportant, as there was no market for the substance they witnessed. The seepage, however, provided a tiny clue to the vast storehouse of hydrocarbons trapped in the earth`s crust extending from the uplands, through Louisiana`s swamps and marshes, and into the subaqueous habitats of the Gulf of Mexico-the world`s ninth largest body of water. In all cases, each move into a new geographic province required considerable change in operation philosophy and in the science supporting the exploration and development activity. As technology changed, or was developed to meet the industry`s needs, new frontiers were explored. However, with time-as is the case with any nonrenewable resource-fields and wells lost their productive life. They had to be abandoned. In fact, the Minerals Management Service suggests that within the next 10 years the offshore industry will remove 150 platforms per year, or nearly half of the current number of production units. The industry will be asked to dispose of nearly one unit every 2.4 days. If this is the case, abandonment issues are going to continue to surface.

  15. Addressing Teachers' Feelings of Lack of Control over Policy Issues

    ERIC Educational Resources Information Center

    Judson, Eugene

    2014-01-01

    This study reports on how an American Education System course, traditionally taught with broad objectives, was contextualized for science teachers. Using pre-assessment data, specific policy issues were targeted with the objective of increasing teachers' feelings of influence over issues. The approach used was adapted from exposure therapy, a…

  16. Human cytomegalovirus and transplantation: drug development and regulatory issues.

    PubMed

    McIntosh, Megan; Hauschild, Benjamin; Miller, Veronica

    2016-01-01

    Cytomegalovirus (CMV) infection is highly prevalent worldwide and can cause serious disease among immunocompromised individuals, including persons with HIV and transplant recipients on immunosuppressive therapies. It can also result in congenital cytomegalovirus when women are infected during pregnancy. Treatment and prevention of CMV in solid organ and haematopoietic stem cell transplant recipients is accomplished in one of three ways: (1) prophylactic therapy to prevent CMV viraemia; (2) pre-emptive therapy for those with low levels of replicating virus; and (3) treatment for established disease. Despite the high prevalence of CMV, there are few available approved drug therapies, and those that are available are hampered by toxicity and less-than-optimal efficacy. New therapies are being developed and tested; however, inconsistency in standardisation of virus levels and questions about potential endpoints in clinical trials present regulatory hurdles that must be addressed. This review covers the current state of CMV therapy, drugs currently under investigation, and clinical trial issues and questions that are in need of resolution. PMID:27482453

  17. Imaginative Thinking: Addressing Social Justice Issues through MovieMaker

    ERIC Educational Resources Information Center

    Boske, Christa A.

    2009-01-01

    Purpose: The purpose of this paper is to examine the experiences of aspiring school leaders who utilized artmaking in this case, photography, poetry, music, collage, and short films through Microsoft MovieMaker as a means for addressing injustices within surrounding school communities. The paper aims to explore how aspiring school leaders…

  18. Teaching Writing in a Digital Age: Addressing Issues of Access

    ERIC Educational Resources Information Center

    Cottrill, Brittany B.

    2010-01-01

    The way people write and communicate has changed both inside and outside the university, and because of this writing instructors are professionally responsible for addressing these changes in the classroom. Technologies have affected writing for thousands of years. From the invention of the printing press to the Internet, challenges to writing…

  19. Teacher Education's Responsibility to Address Diversity Issues: Enhancing Institutional Capacity.

    ERIC Educational Resources Information Center

    Melnick, Susan L.; Zeichner, Kenneth M.

    1998-01-01

    Preservice teachers must be prepared to address substantial student diversity and to educate all students to higher levels of understanding and competence. Many teacher educators are not competent to prepare new teachers in this area. Several approaches to handling institutional aspects of teacher education for diversity are discussed, noting…

  20. Bulimia: Issues a University Counseling Center Needs To Address.

    ERIC Educational Resources Information Center

    Whitner, Phillip A.; Shetterly, Arminta

    The eating disorder known as bulimia is a relatively new and baffling phenomenon. This paper raises questions that college and university counseling center professionals need to address regarding this phenomenon. The first section focuses on defining the term "bulimia" and its evolution. The second section identifies numerous symptoms that need to…

  1. Addressing the human factors issues associated with control room modifications

    SciTech Connect

    O`Hara, J.; Stubler, W.; Kramer, J.

    1998-03-01

    Advanced human-system interface (HSI) technology is being integrated into existing nuclear plants as part of plant modifications and upgrades. The result of this trend is that hybrid HSIs are created, i.e., HSIs containing a mixture of conventional (analog) and advanced (digital) technology. The purpose of the present research is to define the potential effects of hybrid HSIs on personnel performance and plant safety and to develop human factors guidance for safety reviews of them where necessary. In support of this objective, human factors issues associated with hybrid HSIs were identified. The issues were evaluated for their potential significance to plant safety, i.e., their human performance concerns have the potential to compromise plant safety. The issues were then prioritized and a subset was selected for design review guidance development.

  2. Adolescent Social Issues: Using Media to Address Crucial Concerns.

    ERIC Educational Resources Information Center

    Sokoloff, Michele

    1987-01-01

    This article describes media resources available to help adolescents deal with a variety of social concerns, including substance abuse, dropouts, Acquired Immune Deficiency Syndrome (AIDS), suicide, and pregnancy. A list of 56 companies that provide resources dealing with social issues is also provided. (LRW)

  3. Creating Art Environments That Address Social Justice Issues

    ERIC Educational Resources Information Center

    Tremblay, Gail

    2013-01-01

    In this article, I examine strategies for teaching students to make socially conscious art using a variety of media that emphasizes installation work. I present issues of social justice in the contemporary art world and include concerns of censorship that artists sometimes confront. I offer examples of team taught coordinated studies programs…

  4. Courts Continue to Address the Wealth Disparity Issue.

    ERIC Educational Resources Information Center

    La Morte, Michael W.

    1989-01-01

    A review of case law on the constitutionality of state school finance provisions on equal protection and equal adequacy grounds is provided. Protracted rounds of litigation over the years in several states and a rash of recent suits reveal that this issue remains lively and contentious. (TJH)

  5. The Courage To Care: Addressing Sexual Minority Issues on Campus.

    ERIC Educational Resources Information Center

    Ottenritter, Nan

    1998-01-01

    Sexual minority students face issues similar to those of ethnic and racial minority students. This article provides a framework for assessing the community college's inclusion of sexual minority students: lesbians, gays, bisexual, and transgender (LGBT) individuals. The first section of the article assesses community colleges in terms of sexual…

  6. Legal Considerations of Internet Use--Issues To Be Addressed.

    ERIC Educational Resources Information Center

    Thomas, Daphyne Saunders; Forcht, Karen A.; Counts, Peter

    1998-01-01

    Explores issues related to legal considerations of the widespread use of the Internet worldwide. Topics considered include: e-mail; data theft and piracy; search and seizure; electronic banking; offensive behavior; liability; copyright infringement; laws regulating the Internet; and the Telecommunications Act. (PEN)

  7. Teaching for Diversity: Addressing Diversity Issues in Responsive ESL Instruction

    ERIC Educational Resources Information Center

    Fu, Jing

    2013-01-01

    Student diversity has become a typical phenomenon in American public schools. The impact of increasing diversity on literacy instruction is unchallenged. Teachers reinforce this message by often citing ESL student diversity as a barrier for literacy teaching. In order to better understand the complexity of diversity issues, I explored two ESL…

  8. Plan for addressing issues relating to oil shale plant siting

    SciTech Connect

    Noridin, J. S.; Donovan, R.; Trudell, L.; Dean, J.; Blevins, A.; Harrington, L. W.; James, R.; Berdan, G.

    1987-09-01

    The Western Research Institute plan for addressing oil shale plant siting methodology calls for identifying the available resources such as oil shale, water, topography and transportation, and human resources. Restrictions on development are addressed: land ownership, land use, water rights, environment, socioeconomics, culture, health and safety, and other institutional restrictions. Descriptions of the technologies for development of oil shale resources are included. The impacts of oil shale development on the environment, socioeconomic structure, water availability, and other conditions are discussed. Finally, the Western Research Institute plan proposes to integrate these topics to develop a flow chart for oil shale plant siting. Western Research Institute has (1) identified relative topics for shale oil plant siting, (2) surveyed both published and unpublished information, and (3) identified data gaps and research needs. 910 refs., 3 figs., 30 tabs.

  9. Reservoir technology research at LBL addressing geysers issues

    SciTech Connect

    Lippmann, M.J.; Bodvarsson, G.S.

    1990-04-01

    The Geothermal Technology Division of the Department of Energy is redirecting a significant part of its Reservoir Technology funding to study problems now being experienced at The Geysers. These include excessive pressure drawdown and associated decline in well flow rates, corrosion due to high chloride concentration in the produced steam and high concentration of noncondensible gases in some parts of the field. Lawrence Berkeley Laboratory (LBL) is addressing some of these problems through field, laboratory and theoretical studies. 11 refs., 6 figs.

  10. Regulatory issues and assumptions associated with barriers in the vadose zone surrounding buried waste

    SciTech Connect

    Siskind, B.; Heiser, J.

    1993-02-01

    One of the options for control of contaminant migration from buried waste sites is the construction of a subsurface barrier that consists of a wall of low permeability material. The barrier material should be compatible with soil and waste conditions specific to the site and have as low an effective diffusivity as is reasonably achievable to minimize or inhibit transport of moisture and contaminants. This report addresses the regulatory issues associated with the use of non-traditional organic polymer barriers as well as the use of soil-bentonite or cement-bentonite mixtures for such barriers, considering barriers constructed from these latter materials to be a regulatory baseline. The regulatory issues fall into two categories. The first category consists of issues associated with the acceptability of such barriers to the EPA as a method for achieving site or performanceimprovement. The second category encompasses those regulatory issues concerning health, safety and the environment which must be addressed regarding barrier installation and performance, especially if non-traditional materials are to be used.

  11. Regulatory affairs issues and legal ontologies in drug development.

    PubMed

    Munteanu, Cristian Robert; Dorado, Julian; Matei-Ilfoveanu, Ion; Nita, Silvia Ana

    2013-01-01

    It usually can take more than ten years from the time a new drug is discovered, until can be launched on the market. Regulatory requirements are part of the process of drug discovery and drug development. It acts at every developmental stage. Regulatory affairs works to establish an effective and uniform balance between voluntary and regulatory compliance and agency responsiveness to consumer needs. It evaluates and coordinates all proposed legal actions to ascertain compliance with regulatory policy. The ontology presented for regulatory affairs and drug research and development gives us the possibility to correlate information from different levels and to discover new relationships between the legal aspects. In addition, the transparency of the information is affected by the inability of existing integration strategies to organize and apply the available knowledge to the range of real scientific and business issue in critical safety and regulatory applications. Therefore, the semantic technologies based on ontologies make the knowledge reusable by several applications across business, from discovery to corporate affairs. PMID:23277001

  12. Geriatric education centers address medication issues affecting older adults.

    PubMed Central

    Kahl, A; Blandford, D H; Krueger, K; Zwick, D I

    1992-01-01

    Serious problems have been identified in the prescribing of medications for elderly patients and use of prescription and nonprescription drugs by older persons. Overuse, underuse, and inappropriate use of drugs by the elderly have been widely documented, and the harmful consequences have been described. This paper reviews information concerning the need for action to improve health professionals' knowledge and skills with respect to drugs and the elderly and activities being undertaken by geriatric education centers (GECs) to enhance these capacities. Grant support for the centers from the Health Resources and Services Administration, a Public Health Service component agency, began in 1983. In fiscal year 1992 there are 31 centers operating in 26 States. The centers are multi-institutional and conduct four types of educational activities. These include review of pharmacological issues for multidisciplinary groups, specialized training for pharmacists, discipline-specific programs focusing on medication issues, and activities aimed at educating the public. Examples of the GECs' educational activities are given. PMID:1738807

  13. Ethnocentric approach to address South Asian health issues.

    PubMed

    Sharif, A

    2012-09-01

    South Asian populations have distinct healthcare requirements to other ethnic demographics. Epidemiologically they constitute a high-risk group for many public health diseases such as cardiovascular disease, chronic kidney disease and diabetes mellitus. Despite individuals of South Asian backgrounds encompassing many individual countries, cultures, religions and backgrounds they share many common health concerns that are poorly tackled in established models of healthcare delivery. To successfully address this burgeoning public health burden, it is important for healthcare professionals and providers to appreciate the need for an ethnocentric approach to South Asian health requirements. Key stakeholders need to understand the need for an integrated ethnocentric approach to challenge the poor health status of this population. Appreciation of the socio-cultural dimension to South Asian healthcare requirements should help guide targeted and focused strategies to improve the outlook for this unique population at high public health risk. PMID:22753671

  14. Addressing Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) Issues in Teacher Education: Teacher Candidates' Perceptions

    ERIC Educational Resources Information Center

    Kitchen, Julian; Bellini, Christine

    2012-01-01

    Homophobic harassment and bullying are persistent issues in Canadian schools despite recent initiatives to improve school climate. Among the reasons is that educators feel reluctant or ill-prepared to address these issues. The purpose of this paper is to examine how teacher education can help make schools safer by addressing LGBTQ issues and…

  15. Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells

    PubMed Central

    Knoepfler, Paul S

    2013-01-01

    The production of human induced pluripotent stem cells (hiPSCs) has greatly expanded the realm of possible stem cell-based regenerative medicine therapies and has particularly exciting potential for autologous therapies. However, future therapies based on hiPSCs will first have to address not only similar regulatory issues as those facing human embryonic stem cells with the US FDA and international regulatory agencies, but also hiPSCs have raised unique concerns as well. While the first possible clinical use of hiPSCs remains down the road, as a field it would be wise for us to anticipate potential roadblocks and begin formulating solutions. In this article, I discuss the potential regulatory issues facing hiPSCs and propose some potential changes in the direction of the field in response. PMID:22830621

  16. Gender Differences in Cancer Susceptibility: An Inadequately Addressed Issue

    PubMed Central

    Dorak, M. Tevfik; Karpuzoglu, Ebru

    2012-01-01

    The gender difference in cancer susceptibility is one of the most consistent findings in cancer epidemiology. Hematologic malignancies are generally more common in males and this can be generalized to most other cancers. Similar gender differences in non-malignant diseases including autoimmunity, are attributed to hormonal or behavioral differences. Even in early childhood, however, where these differences would not apply, there are differences in cancer incidence between males and females. In childhood, few cancers are more common in females, but overall, males have higher susceptibility. In Hodgkin lymphoma, the gender ratio reverses toward adolescence. The pattern that autoimmune disorders are more common in females, but cancer and infections in males suggests that the known differences in immunity may be responsible for this dichotomy. Besides immune surveillance, genome surveillance mechanisms also differ in efficiency between males and females. Other obvious differences include hormonal ones and the number of X chromosomes. Some of the differences may even originate from exposures during prenatal development. This review will summarize well-documented examples of gender effect in cancer susceptibility, discuss methodological issues in exploration of gender differences, and present documented or speculated mechanisms. The gender differential in susceptibility can give important clues for the etiology of cancers and should be examined in all genetic and non-genetic association studies. PMID:23226157

  17. Electric utility industry addresses issue of global climate change

    SciTech Connect

    Not Available

    1989-04-01

    Global climate change is a high priority issue for the electric utility industry, and careful consideration is under-way of numerous options to deal effectively with the potential consequences. The earth's temperature has risen about 0.5 degrees Celsius during the past 100 years. It is not known, however, whether this warning is part of a natural cycle or whether man-made emissions will cause additional warning. Scientists speculate the earth's temperature would have to rise another four to five degrees Celsius for significant adverse effects to result from global warming. The utility industry plans to give careful consideration to an array of supply and demand options, he said. Reliable and affordable electric generation is imperative to our society and will be increasingly important in helping societies adapt if global warning does occur. The nation needs a balanced energy mix to ensure an adequate energy supply. The development of new clean coal burning technologies is essential and should be accelerated to increase efficiency and minimize atmospheric emissions. The utility industry is also looking at processes that will reduce CO{sub 2} emissions in the industrial and transportation sectors.

  18. "Cairo must address the equity issue." Interview: Sandra Postel.

    PubMed

    1994-01-01

    Sandra Postel, of the Worldwatch Institute, believes that inequalities in consumption and income foster environmental degradation. The richest 20% are getting richer and consuming excessively. The bottom 20%, comprising about 1 billion people, are getting poorer and are degrading their environment in order to survive. Per capita availability of resources is continually being reduced. If there is a desire to improve the quality of life for the poorest segment of the world population, then the richest must forfeit something. Environmental taxation could reduce excessive consumption in general; this strategy would be the most efficient and useful. Taxes would be placed on pollution and resources in danger of depletion; income taxes could be reduced to balance the impact of increased taxes on the economy. Wealthy countries must make a renewed commitment to poverty alleviation and to realistic sustainable development. Aid budgets should no longer reflect military priorities or strategic objectives. Trade is clearly related to the environment and poverty, and these connections must be made publicly known. National and international trade policies must deal with poverty issues and not contribute to further environmental destruction. Eliminating debt problems is another problem in need of change. The World Bank and structural adjustment policies have not proved to be environmentally sound and have not benefitted the poor. Evaluation of programs is needed, and lending policies should reflect the growing awareness of the problems of the poor and environmental consequences. Consumption of energy, wood, paper, and water are all higher among industrialized wealthy countries. Technology needs to be applied to maximize resource use, and policies must reflect this commitment. Israel has set a good example with water consumption reduction through advanced technology. PMID:12345839

  19. Developing integrated methods to address complex resource and environmental issues

    USGS Publications Warehouse

    2016-01-01

    IntroductionThis circular provides an overview of selected activities that were conducted within the U.S. Geological Survey (USGS) Integrated Methods Development Project, an interdisciplinary project designed to develop new tools and conduct innovative research requiring integration of geologic, geophysical, geochemical, and remote-sensing expertise. The project was supported by the USGS Mineral Resources Program, and its products and acquired capabilities have broad applications to missions throughout the USGS and beyond.In addressing challenges associated with understanding the location, quantity, and quality of mineral resources, and in investigating the potential environmental consequences of resource development, a number of field and laboratory capabilities and interpretative methodologies evolved from the project that have applications to traditional resource studies as well as to studies related to ecosystem health, human health, disaster and hazard assessment, and planetary science. New or improved tools and research findings developed within the project have been applied to other projects and activities. Specifically, geophysical equipment and techniques have been applied to a variety of traditional and nontraditional mineral- and energy-resource studies, military applications, environmental investigations, and applied research activities that involve climate change, mapping techniques, and monitoring capabilities. Diverse applied geochemistry activities provide a process-level understanding of the mobility, chemical speciation, and bioavailability of elements, particularly metals and metalloids, in a variety of environmental settings. Imaging spectroscopy capabilities maintained and developed within the project have been applied to traditional resource studies as well as to studies related to ecosystem health, human health, disaster assessment, and planetary science. Brief descriptions of capabilities and laboratory facilities and summaries of some

  20. How State Regulatory Agencies Address Privatization: The Case of Wastewater Treatment.

    ERIC Educational Resources Information Center

    Heilman, John G.; Johnson, Gerald W.

    1991-01-01

    How state agencies have addressed privatization in a service setting (municipal wastewater treatment) is discussed. The implications for evaluations of many types of programs, particularly those of local service programs regulated by the states, are explored. Data from a national survey of state environmental regulatory agencies are highlighted.…

  1. Issue-Specific Barriers to Addressing Environmental Issues in the Classroom: An Exploratory Study

    ERIC Educational Resources Information Center

    Kim, Chankook; Fortner, Rosanne W.

    2006-01-01

    To explore issue-specific barriers to teaching environmental issues, the authors investigated secondary science teachers' perceived current and preferred teaching levels for 23 environmental issues and perceived barriers to teaching the selected issues. Subjects in this graduate project were 41 secondary science teachers self-selected to answer a…

  2. Utilizing Internet-based Community Collaboration Tools and Geobrowsers to Address Issues of Water Resource Sustainability

    NASA Astrophysics Data System (ADS)

    D'Agnese, F. A.

    2007-12-01

    More frequently society is demanding that earth- and environmental-resource issues be evaluated and addressed by interdisciplinary investigators from the scientific, engineering, planning, and regulatory communities. Often these investigators are required to interact with a larger community of public stakeholders. Also, these investigators, by necessity, develop databases and models derived from disparate data sets that are often large, complex, and vary dramatically in scale and quality. The tools to facilitate the interactions of these communities of individuals have only recently garnered the appropriate sophistication to enable real-time data viewing, encoding, browsing, and modeling. At the same time, the advent of second-generation internet, or Web 2.0, technologies found in web-based communities and hosted services (such as social-networking, wikis, weblogs, social bookmarking, podcasts, and RSS web feeds) have fused with the more traditional two- and three-dimensional geographic information systems. This "mash-up" of web-based and stand-alone tools and services creates a highly interactive user environment that is favorable to real-time collaboration, community discussion, and broad public dissemination in a wide-area distributed network. These tools and services are being utilized to facilitate the investigations and conversations of scientists and other stakeholders addressing water resource sustainability issues in the desert southwestern United States. The data and models derived from these investigations are visualized using industry standard tools like ArcGIS, Google Earth, and Google Maps to enable ease-of-use by both the technical and the public stakeholder communities.

  3. ENRICH Forum: Ethical aNd Regulatory Issues in Cancer ResearcH

    Cancer.gov

    ENRICH Forum: Ethical aNd Regulatory Issues in Cancer ResearcH, designed to stimulate dialogue on ethical and regulatory issues in cancer research and promote awareness of developing policies and best practices.

  4. RFID in healthcare environment: electromagnetic compatibility regulatory issues.

    PubMed

    Censi, Federica; Calcagnini, Giovanni; Mattei, Eugenio; Triventi, Michele; Bartolini, Pietro

    2010-01-01

    Several wireless technology applications (RFID, WiFi, GSM, GPRS) have been developed to improve patient care, reaching a significant success and diffusion in healthcare. Given the potential development of such a technology, care must be paid on the potential risks deriving from the use of wireless device in healthcare, among which one of the most important is the electromagnetic interference with medical devices. The analysis of the regulatory issues concerning the electromagnetic compatibility of medical devices is essential to evaluate if and how the application of the current standards allows an effective control of the possible risks associated to the electromagnetic interference on medical devices. PMID:21096973

  5. U.S. perspective on mycotoxin regulatory issues.

    PubMed

    Park, Douglas L; Troxell, Terry C

    2002-01-01

    Control programs set up by the Food and Drug Administration (FDA) for aflatoxin, an unavoidable natural contaminant produced by specific molds that invade a number of feedstuffs and basic foods, provide an example of forces that affect risk assessment and management strategies by a regulatory agency. More recently, on an international scale, efforts to establish international food standards for fumonisin, deoxynivalenol, ochratoxin A, zearalenone, and patulin, as well as for aflatoxin, demonstrate the complexity of developing regulations and/or standards designed to protect consumer health and ensure fair trade practices on a global scale. Current FDA regulations for aflatoxins address public health concerns for potential contamination in basic foods, residues in milk, and animal feeds for numerous commodities and applications. Regulatory limits, sampling and analytical procedures, decontamination and/or diversion to less risk uses for contaminated product are components of mycotoxin control programs. Current efforts by FDA to establish regulatory controls for deoxynivalenol, fumonisin, and patulin add further insight on the role that safety and risk assessment procedures play in the development of action levels and advisories for mycotoxins. PMID:11922095

  6. 75 FR 44781 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... COMMISSION SECURITIES AND EXCHANGE COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues...''). ACTION: Notice of Meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting...

  7. 76 FR 6120 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... COMMISSION SECURITIES AND EXCHANGE COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues...''). ACTION: Notice of Meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting...

  8. 75 FR 66362 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... COMMISSION SECURITIES AND EXCHANGE COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues...''). ACTION: Notice of meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting...

  9. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  10. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  11. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  12. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  13. 10 CFR Appendix A to Part 73 - U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false U.S. Nuclear Regulatory Commission Offices and Classified Mailing Addresses A Appendix A to Part 73 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Pt. 73, App. A Appendix A to Part 73—U.S. Nuclear Regulatory...

  14. NIH Research Addresses Aging Issues and Disparities in Oral Health | NIH MedlinePlus the Magazine

    MedlinePlus

    ... JavaScript on. Feature: Oral Health and Aging NIH Research Addresses Aging Issues and Disparities in Oral Health ... NIH Why is it important to have a research focus on older adults? One reason is that ...

  15. The New ASERVIC Competencies for Addressing Spiritual and Religious Issues in Counseling

    ERIC Educational Resources Information Center

    Cashwell, Craig S.; Watts, Richard E.

    2010-01-01

    In 2009, leaders in the Association for Spiritual, Ethical and Religious Values in Counseling (ASERVIC) developed new competencies for addressing spiritual and religious issues in counseling. This article briefly addresses the need for new ASERVIC competencies, provides an overview of the process whereby the new competencies emerged, and concludes…

  16. Addressing Individual Difficulties in Reading: Issues Relating to Reading Recovery and Pause, Prompt, Praise

    ERIC Educational Resources Information Center

    Wearmouth, Janice

    2004-01-01

    Recently the DfES has issued guidance on ways to address the needs of students who experience difficulties in literacy through Wave Three provision in the National Literacy Strategy (DfES, 2002). This guidance raises the issue of what kind of programmes might be initiated in mainstream schools that will improve what is available generally for…

  17. Sarah's Story: Using Ritual Therapy to Address Psychospiritual Issues in Treating Survivors of Childhood Sexual Abuse.

    ERIC Educational Resources Information Center

    Parker, Radha J.; Horton, H. Shelton, Jr.; Watson, Terri

    1997-01-01

    Describes an individual's healing from the trauma of childhood sexual abuse through counseling, spiritual growth, and the use of therapeutic ritual. Explores relationships between the psychospiritual issues associated with childhood sexual abuse and commonly designated treatment goals. Claims that addressing psychospiritual issues is crucial in…

  18. Bringing a probiotic-containing functional food to the market: microbiological, product, regulatory and labeling issues.

    PubMed

    Sanders, M E; Huis in't Veld, J

    1999-01-01

    Properly formulated probiotic-containing foods offer consumers a low risk, low cost dietary component that has the potential to promote health in a variety of ways. Several such products are available commercially, although markets in Japan and Europe are more developed than in the USA. Once healthful attributes of a probiotic product have been identified, there remain microbiological, product, regulatory and labeling issues to be addressed prior to marketing. Microbiological and product issues include safety, effective scale-up for manufacturing, definition of probiotic activity, probiotic stability in the product over the course of product manufacture, shelf-life and consumption, definition of effective dose and target population(s), and development of quality assurance approaches. Examples of probiotic-containing foods are given. Regulatory and labeling issues are complicated because they differ for each country, but are likewise critical because they provide the means for communication of the product benefits to the consumer. The regulatory climate worldwide appears to be one of caution about overstating the benefits of such products but at the same time not preventing corporate commitment to marketing. PMID:10532385

  19. 76 FR 2924 - Proposed Generic Communications; Draft NRC Regulatory Issue Summary 2011-XX; Adequacy of Station...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... Electric Distribution System Voltages AGENCY: Nuclear Regulatory Commission. ACTION: Notice of opportunity... protection) setting bases and Transmission Network/ Offsite/Onsite station electric power system design bases... INFORMATION: ] NRC Regulatory Issue Summary 2011-XX; Adequacy of Station Electric Distribution System...

  20. Regulatory policy issues and the Clean Air Act: Issues and papers from the state implementation workshops

    SciTech Connect

    Rose, K.; Burns, R.E.

    1993-07-01

    The National Regulatory Research Institute (NRRI), with funding from the US Environmental Protection Agency (EPA) and the US Department of Energy (DOE), conducted four regional workshops` on state public utility commission implementation of the Clean Air Act Amendments of 1990 (CAAA). The workshops had four objectives: (1) to discuss key issues and concerns on CAAA implementation, (2) to encourage a discussion among states on issues of common interests, (3) to attempt to reach consensus, where possible, on key issues, and (4) to provide the workshop participants with information and materials to assist in developing state rules, orders, and procedures. From the federal perspective, a primary goal was to ensure that workshop participants return to their states with a comprehensive background and understanding of how state commission actions may affect implementation of the CAAA and to be able to provide guidance to their jurisdictional utilities. It was hoped that this would reduce some of the uncertainty utilities face and assist in the development of an efficient allowance market. This report is divided into two main sections. In Section II, eleven principal issues are identified and discussed. These issues were chosen because they were either the most frequently discussed or they were related to the questions asked in response to the speakers` presentations. This section does not cover all the issues relevant to state implementation nor all the issues discussed at the workshops; rather, Section II is intended to provide an overview of the,planning, ratemaking, and multistate issues. Part III is a series of workshop papers presented by some of the speakers. Individual papers have been cataloged separately.

  1. Regulatory issues and assumptions associated with polymers for subsurface barriers surrounding buried waste

    SciTech Connect

    Heiser, J.; Siskind, B.

    1993-11-01

    One of the options for control of contaminant migration from buried waste sites is the construction of a subsurface barrier that consists of a wall of low permeability material. Subsurface barriers will improve remediation performance by removing pathways for contaminant transport due to groundwater movement, meteorological water infiltration, vapor- and gas-phase transport, transpiration, etc. Subsurface barriers may be used to {open_quotes}direct{close_quotes} contaminant movement to collection sumps/lysimeters in cases of unexpected remediation failures or transport mechanisms, to contain leakage from underground storage tanks, and to restrict in-situ soil cleanup operation and chemicals. Brookhaven National Laboratory is currently investigating advanced polymer materials for subsurface barriers. This report addresses the regulatory aspects of using of non-traditional polymer materials as well as soil-bentonite or cement-bentonite mixtures for such barriers. The regulatory issues fall into two categories. The first category consists of issues associated with the acceptability of subsurface barriers to the Environmental Protection Agency (EPA) as a method for achieving waste site performance improvement. The second category encompasses those regulatory issues concerning health, safety and the environment which must be addressed regarding barrier installation and performance, especially if non-traditional materials are to be used. Since many of EPA`s concerns regarding subsurface barriers focus on the chemicals used during installation of these barriers the authors discuss the results of a search of the Federal Register and the Code of Federal Regulations for references in Titles 29 and 40 pertaining to key chemicals likely to be utilized in installing non-traditional barrier materials. The use of polymeric materials in the construction industry has been accomplished with full compliance with the applicable health, safety, and environmental regulations.

  2. The Importance of Exposure in Addressing Current and Emerging Air Quality Issues

    EPA Science Inventory

    The air quality issues that we face today and will face in the future are becoming increasingly more complex and require an improved understanding of human exposure to be effectively addressed. The objectives of this paper are (1) to discuss how concepts of human exposure and ex...

  3. From Professional Development to Classroom Instruction: Addressing Issues Related to Science Inquiry Discourse

    ERIC Educational Resources Information Center

    Oliveira, Alandeom W.

    2009-01-01

    In this rejoinder, I first provide a more detailed account of the discourse-focused professional development activities facilitated as part of the SMIT'N program, specifically addressing issues raised by van Zee with regard to the institute's overall format, goals and development strategies. Next, I resort to Peter Medawar's metaphorical view of…

  4. 49 CFR 192.933 - What actions must be taken to address integrity issues?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false What actions must be taken to address integrity issues? 192.933 Section 192.933 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND...

  5. Are Educational Leadership Candidates Prepared to Address Diversity Issues in Schools?

    ERIC Educational Resources Information Center

    Chan, Tak C.

    2006-01-01

    Standard 4 of the Educational Leadership Constituency Council (ELCC) Standards addresses school diversity issues and specifies requirements that all educational leadership programs need to meet. In response, all educational leadership programs in Georgia referenced ELCC Standards and have worked to foster diversity as a priority in their programs.…

  6. Race and Science: Using a Comprehensive Interdisciplinary Approach To Address Complex Issues.

    ERIC Educational Resources Information Center

    Eisen, Arri; Cimino, Ashley; Aparicio, Hugo; Marsteller, Patricia; Kushner, Howard

    2003-01-01

    Describes an interdisciplinary approach that integrates the strengths of a research and teaching institution to address issues in a complex problem: the study of race, science, and health. The model involved a feedback loop among two undergraduate courses and a weekly seminar. (SLD)

  7. Addressing Issues of Religious Difference through Values Education: An Islam Instance

    ERIC Educational Resources Information Center

    Lovat, Terence; Clement, Neville; Dally, Kerry; Toomey, Ron

    2010-01-01

    The article's main focus is on exploring ways in which modern forms of values education are being utilized to address major issues of social dissonance, with special focus on dissonance related to religious difference between students of Islamic and non-Islamic backgrounds. The article begins by appraising philosophical and neuroscientific…

  8. Beyond the Dialectics and Polemics: Canadian Catholic Schools Addressing LGBT Youth Issues

    ERIC Educational Resources Information Center

    Liboro, Renato M.; Travers, Robb; St. John, Alex

    2015-01-01

    In 2012, Canadian media coverage on Bill 13--an Ontario legislative proposal to require all publicly funded schools to support Gay-Straight Alliances as a means of addressing issues concerning bullied lesbian, gay, bisexual, and transgender (LGBT) students--instigated a divisive exchange among representatives of the Ontario Catholic school sector.…

  9. Recommendations and Strategies for Addressing Comprehensive Health Issues on Two-Year College Campuses.

    ERIC Educational Resources Information Center

    Winter, Gene M.; And Others

    The Two-Year College Development Center invited representatives from two-year colleges throughout New York to attend a two-day meeting to address comprehensive health issues, particularly pertaining to the transmission and prevention of Acquired Immune Deficiency Syndrome (AIDS), as well as other infectious and chronic diseases. The attending…

  10. Clinical Behaviors for Addressing Religious/Spiritual Issues: Do We Practice What We Preach?

    ERIC Educational Resources Information Center

    Cashwell, Craig S.; Young, J. Scott; Fulton, Cheryl L.; Willis, Ben T.; Giordano, Amanda; Daniel, Laura Wyatt; Crockett, Jamie; Tate, B. Nicole; Welch, Metoka L.

    2013-01-01

    To determine if counselors integrate clinical behaviors for addressing religious/spiritual issues in counseling consistent with their ratings of the importance of such behaviors, the authors conducted a national survey of American Counseling Association (ACA) members. Seventy-eight ACA members rated the importance of and frequency with which they…

  11. Regulatory issues associated with closure of the Hanford AX Tank Farm ancillary equipment

    SciTech Connect

    Becker, D.L.

    1998-09-02

    Liquid mixed, high-level radioactive waste has been stored in underground single-shell tanks at the US Department of Energy`s (DOE`s) Hanford Site. After retrieval of the waste from the single-shell tanks, the DOE will proceed with closure of the tank farm. The 241-AX Tank Farm includes four one-million gallon single-shell tanks in addition to sluice lines, transfer lines, ventilation headers, risers, pits, cribs, catch tanks, buildings, well and associated buried piping. This equipment is classified as ancillary equipment. This document addresses the requirements for regulatory close of the ancillary equipment in the Hanford Site 241-AX Tank Farm. The options identified for physical closure of the ancillary equipment include disposal in place, disposal in place after treatment, excavation and disposal on site in an empty single-shell tank, and excavation and disposal outside the AX Tank Farm. The document addresses the background of the Hanford Site and ancillary equipment in the AX Tank Farm, regulations for decontamination and decommissioning of radioactively contaminated equipment, requirements for the cleanup and disposal of radioactive wastes, cleanup and disposal requirements governing hazardous and mixed waste, and regulatory requirements and issues associated with each of the four physical closure options. This investigation was conducted by the Sandia National Laboratories, Albuquerque, New Mexico, during Fiscal Year 1998 for the Hanford Tanks Initiative Project.

  12. Regulatory and ethical issues for phase I in utero gene transfer studies.

    PubMed

    Strong, Carson

    2011-11-01

    Clinical gene transfer research has involved adult and child subjects, and it is expected that gene transfer in fetal subjects will occur in the future. Some genetic diseases have serious adverse effects on the fetus before birth, and there is hope that prenatal gene therapy could prevent such disease progression. Research in animal models of prenatal gene transfer is actively being pursued. The prospect of human phase I in utero gene transfer studies raises important regulatory and ethical issues. One issue not previously addressed arises in applying U.S. research regulations to such studies. Specifically, current regulations state that research involving greater than minimal risk to the fetus and no prospect of direct benefit to the fetus or pregnant woman is not permitted. Phase I studies will involve interventions such as needle insertions through the uterus, which carry risks to the fetus including spontaneous abortion and preterm birth. It is possible that these risks will be regarded as exceeding minimal. Also, some regard the probability of therapeutic benefit in phase I studies to be so low that these studies do not satisfy the regulatory requirement that they "hold out the prospect of direct benefit" to subjects. On the basis of these considerations, investigators and institutional review boards might reasonably conclude that some phase I in utero studies are not to be permitted. This paper identifies considerations that are relevant to such judgments and explores ethically acceptable ways in which phase I studies can be designed so that they are permitted by the regulations. PMID:21846200

  13. Multiple views to address diversity issues: an initial dialog to advance the chiropractic profession

    PubMed Central

    Johnson, Claire; Killinger, Lisa Zaynab; Christensen, Mark G.; Hyland, John K.; Mrozek, John P.; Zuker, R. Fred; Kizhakkeveettil, Anupama; Perle, Stephen M.; Oyelowo, Tolu

    2012-01-01

    The purpose of this article is to provide expert viewpoints on the topic of diversity in the chiropractic profession, including cultural competency, diversity in the profession, educational and clinical practice strategies for addressing diversity, and workforce issues. Over the next decades, changing demographics in North America will alter how the chiropractic profession functions on many levels. As the population increases in diversity, we will need to prepare our workforce to meet the needs of future patients and society. PMID:23966884

  14. The role of Violence Against Women Act in addressing intimate partner violence: a public health issue.

    PubMed

    Modi, Monica N; Palmer, Sheallah; Armstrong, Alicia

    2014-03-01

    Intimate partner violence (IPV) is defined as violence committed by a current or former boyfriend or girlfriend, spouse or ex-spouse. Each year, 1.3 to 5.3 million women in the United States experience IPV. The large number of individuals affected, the enormous healthcare costs, and the need for a multidisciplinary approach make IPV an important healthcare issue. The Violence Against Women Act (VAWA) addresses domestic violence, dating violence, sexual assault, and stalking. It emphasizes development of coordinated community care among law enforcement, prosecutors, victim services, and attorneys. VAWA was not reauthorized in 2012 because it lacked bipartisan support. VAWA 2013 contains much needed new provisions for Native Americans; lesbian, gay, bisexual, transgender, gay, and queer (LGBTQ) individuals; and victims of human trafficking but does not address the large amount of intimate partner violence in America's immigrant population. There are important remaining issues regarding intimate partner violence that need to be addressed by future legislation. This review examines the role of legislation and addresses proposals for helping victims of IPV. PMID:24299159

  15. The Role of Violence Against Women Act in Addressing Intimate Partner Violence: A Public Health Issue

    PubMed Central

    Modi, Monica N.; Palmer, Sheallah

    2014-01-01

    Abstract Intimate partner violence (IPV) is defined as violence committed by a current or former boyfriend or girlfriend, spouse or ex-spouse. Each year, 1.3 to 5.3 million women in the United States experience IPV. The large number of individuals affected, the enormous healthcare costs, and the need for a multidisciplinary approach make IPV an important healthcare issue. The Violence Against Women Act (VAWA) addresses domestic violence, dating violence, sexual assault, and stalking. It emphasizes development of coordinated community care among law enforcement, prosecutors, victim services, and attorneys. VAWA was not reauthorized in 2012 because it lacked bipartisan support. VAWA 2013 contains much needed new provisions for Native Americans; lesbian, gay, bisexual, transgender, gay, and queer (LGBTQ) individuals; and victims of human trafficking but does not address the large amount of intimate partner violence in America's immigrant population. There are important remaining issues regarding intimate partner violence that need to be addressed by future legislation. This review examines the role of legislation and addresses proposals for helping victims of IPV. PMID:24299159

  16. Prescription Drug Abuse: Epidemiology, Regulatory Issues, Chronic Pain Management with Narcotic Analgesics

    PubMed Central

    Manubay, Jeanne M.; Muchow, Carrie; Sullivan, Maria A.

    2012-01-01

    Synopsis The epidemic of prescription drug abuse has reached a critical level, which has received national attention. Physicians must learn strategies to effectively treat chronic pain, and help reduce the rates of prescription drug abuse. This chapter will provide insight into the epidemiology of prescription drug abuse, explain regulatory issues, and provide guidelines for the assessment and management of pain, particularly with chronic opioid therapy. The use of informed consent forms, treatment agreements, risk documentation tools, and regular monitoring of the 4 “A's” helps to educate patients, as well as guide management based on treatment goals. By using universal precautions, and being aware of aberrant behaviors, physicians may feel more confident in identifying and addressing problematic behaviors. PMID:21356422

  17. Regulatory issues concerning the safety, efficacy and quality of herbal remedies.

    PubMed

    Rousseaux, Colin G; Schachter, Howard

    2003-12-01

    Herbal remedies and alternative medicines are used throughout the world, and in the past herbs were often the original sources of most drugs. Today we are witnessing an increase in herbal remedy use throughout the Western world raising the question as to how safe are these preparations for the unborn fetus? Many women use herbal products during pregnancy. The dilemma facing most regulatory authorities is that the public considers these products as either traditional medicines or natural food supplements. The user sees no reason for regulation. Most countries have laws concerning foods, drugs, and cosmetics, the details of which seldom clearly define to what section of the law and regulations alternative remedies belong. In most countries alternative remedies are regulated as foods, provided that no medicinal claim is made on the label. The global regulatory sector, however, is changing rapidly. The Therapeutic Goods Administration (TGA) in Australia created a Complimentary Medicines Evaluation Committee in late 1997 to address this issue, and Canada has created a new Natural Health Products Directorate in the realigned Therapeutic Products and Foods Branch in 2000. In parallel, the European Agency for the Evaluation of Medicinal Products has drafted test procedures and acceptance criteria for herbal drug preparations and herbal medicinal products. In the US, the Food and Drug Administration classifies these natural products as dietary supplements. Manufacturers must label a dietary supplement thus: "this statement has not been evaluated by the FDA [, and] this product is not intended to diagnose, treat, cure or prevent any disease." Whether these products are foods or drugs is undecided. To add complexity to this issue, most of the potential deleterious effects of natural products on the unborn may be related to hormonal effects (e.g., phytoestrogens) and nutriceutical drug interactions (e.g., St. John's Wort and antidepressants), rather than direct embryotoxicity

  18. Science Teachers' Use of Mass Media to Address Socio-Scientific and Sustainability Issues

    NASA Astrophysics Data System (ADS)

    Klosterman, Michelle L.; Sadler, Troy D.; Brown, Julie

    2012-01-01

    The currency, relevancy and changing nature of science makes it a natural topic of focus for mass media outlets. Science teachers and students can capitalize on this wealth of scientific information to explore socio-scientific and sustainability issues; however, without a lens on how those media are created and how representations of science are constructed through media, the use of mass media in the science classroom may be risky. Limited research has explored how science teachers naturally use mass media to explore scientific issues in the classroom or how mass media is used to address potential overlaps between socio-scientific-issue based instruction and education for sustainability. This naturalistic study investigated the reported and actual classroom uses of mass media by secondary science teachers' to explore socio-scientific and sustainability issues as well as the extent to which their instructional approaches did or did not overlap with frameworks for SSI-based instruction, education for sustainability, and media literacy education. The results of this study suggest that secondary science teachers use mass media to explore socio-scientific and sustainability issues, but their use of frameworks aligned with SSI-based, education for sustainability, and media literacy education was limited. This paper provides suggestions for how we, as science educators and researchers, can advance a teaching and learning agenda for encouraging instruction that more fully utilizes the potential of mass media to explore socio-scientific issues in line with perspectives from education for sustainability.

  19. Steam generators regulatory practices and issues in Spain

    SciTech Connect

    Mendoza, C.; Castelao, C.; Ruiz-Colino, J.; Figueras, J.M.

    1997-02-01

    This paper presents the actual status of Spanish Steam Generator tubes, actions developed by PWR plant owners and submitted to CSN, and regulatory activities related to tube degradation mechanisms analysis; NDT tube inspection techniques; tube, tubesheet and TSPs integrity studies; tube plugging/repair criteria; preventive and corrective measures including whole SGs replacement; tube leak measurement methods and other operational aspects.

  20. SOFTWARE TOOLS THAT ADDRESS HAZARDOUS MATERIAL ISSUES DURING NUCLEAR FACILITY D and D

    SciTech Connect

    M. COURNOYER; R. GRUNDEMANN

    2001-03-01

    The 49-year-old Chemistry and Metallurgy Research (CMR) Facility is where analytical chemistry and metallurgical studies on samples of plutonium and nuclear materials are conduct in support of the Department of Energy's nuclear weapons program. The CMR Facility is expected to be decontaminated and decommissioned (D and D) over the next ten to twenty years. Over the decades, several hazardous material issues have developed that need to be address. Unstable chemicals must be properly reassigned or disposed of from the workspace during D and D operation. Materials that have critical effects that are primarily chronic in nature, carcinogens, reproductive toxin, and materials that exhibit high chronic toxicity, have unique decontamination requirements, including the decontrolling of areas where these chemicals were used. Certain types of equipment and materials that contain mercury, asbestos, lead, and polychlorinated biphenyls have special provisions that must be addressed. Utilization of commercially available software programs for addressing hazardous material issues during D and D operations such as legacy chemicals and documentation are presented. These user-friendly programs eliminate part of the tediousness associated with the complex requirements of legacy hazardous materials. A key element of this approach is having a program that inventories and tracks all hazardous materials. Without an inventory of chemicals stored in a particular location, many important questions pertinent to D and D operations can be difficult to answer. On the other hand, a well-managed inventory system can address unstable and highly toxic chemicals and hazardous material records concerns before they become an issue. Tapping into the institutional database provides a way to take advantage of the combined expertise of the institution in managing a cost effective D and D program as well as adding a quality assurance element to the program. Using laboratory requirements as a logic flow

  1. Regulatory Issues Encountered when Conducting Longitudinal Substance Abuse Research

    PubMed Central

    Evans, Elizabeth; Murphy, Debra A.; Grella, Christine E.; Mouttapa, Michele; Hser, Yih-Ing

    2008-01-01

    Objective To summarize challenges unique to obtaining Institutional Review Board (IRB) approval for longitudinal substance abuse research, focusing on solutions and lessons learned. Methods Thirteen senior Principal Investigators with experience conducting research on substance abuse treatment and health services outcomes recalled instances from the prior 5 years when obtaining UCLA and non-UCLA IRB approval was hampered by differences in the interpretation of regulatory guidelines and how those differences were resolved. Principal Findings Comprehensive yet flexible research protocols regarding (1) informed and voluntary consent, (2) participant payment, and (3) re-contact efforts are essential for securing IRB approval of longitudinal substance abuse studies. Specific examples of lessons learned are provided. Conclusions Experiences can help researchers to provide appropriate and explicit justification for longitudinal substance abuse research protocols, thereby minimizing the burden and cost associated with meeting regulatory requirements as well as enhancing the efficiency, quantity, and quality of data collected. PMID:20379383

  2. Legal & regulatory issues affecting participation in distributed resource markets

    SciTech Connect

    Nimmons, J.T.

    1996-12-31

    This paper describes recent research co-sponsored by the National Renewable Energy Laboratory and four investor-owned utilities. Its purpose was to investigate how legal and regulatory factors will shape strategic decisions on the roles of utilities and others in the development of distributed resources. The work was performed during 1995 and early 1996 by John Nimmons & Associates, with support from Thomas J. Starts, Energy & Environmental Economics, and Awad & Singer.

  3. 75 FR 34704 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... COMMISSION COMMODITY FUTURES TRADING COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory... (``CFTC'') (each, an ``Agency,'' and collectively, ``Agencies''). ACTION: Notice of Meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. ] SUMMARY: The Joint CFTC-SEC Advisory...

  4. 75 FR 28667 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... COMMISSION COMMODITY FUTURES TRADING COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory... (``CFTC'') (each, an ``Agency,'' and collectively, ``Agencies''). ACTION: Notice of meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory...

  5. 76 FR 28791 - Strategy To Address Recommendations Issued by the Institute of Medicine in November 2010 Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... HUMAN SERVICES Centers for Disease Control and Prevention Strategy To Address Recommendations Issued by...), requests input on the NIOSH, NPPTL strategy to address the recommendations issued by the Institute of... information received in response to this notice will be available for public examination and copying at...

  6. Legal, regulatory & institutional issues facing distributed resources development

    SciTech Connect

    1996-10-01

    This report describes legal, regulatory, and institutional considerations likely to shape the development and deployment of distributed resources. It is based on research co-sponsored by the National Renewable Energy Laboratory (NREL) and four investor-owned utilities (Central & South West Services, Cinergy Corp., Florida Power Corporation, and San Diego Gas & Electric Company). The research was performed between August 1995 and March 1996 by a team of four consulting firms experienced in energy and utility law, regulation, and economics. It is the survey phase of a project known as the Distributed Resources Institutional Analysis Project.

  7. Understanding how older adults living in deprived neighbourhoods address ageing issues.

    PubMed

    Bielderman, Annemiek; Schout, Gert; de Greef, Mathieu; van der Schans, Cees

    2015-08-01

    Older adults living in deprived areas are at risk of developing frailty and becoming care dependent. The aim of this qualitative study is to explore how community-dwelling, older adults living in deprived neighbourhoods address ageing issues. In-depth interviews were conducted with 20 participants who were community-dwelling (independently living), aged 65 years and older, not dependent on care, and living in a socioeconomically deprived urban neighbourhood in the northern part of the Netherlands. Data were analysed using the constant comparative method. Our findings emphasise the resourcefulness of these older adults when coping with apparent adversities. Simultaneously, the findings convey deficits concerning knowledge about ageing and health. Despite this, it appeared that these older adults possess an optimistic view of life, accept their situation, and are content with the capacities they still possess. Perspectives on how older adults address ageing issues are important for developing leads for nursing practice. Nurses will be challenged to recognise the coping strategies of older adults, particularly considering their deficits in health knowledge. The results of this study may serve as a basis for community nurses to manage care for older adults in deprived neighbourhoods. PMID:26252237

  8. Nanosilver and global public health: international regulatory issues.

    PubMed

    Faunce, Thomas; Watal, Aparna

    2010-06-01

    Silver in nanoparticle form is used extensively worldwide in hospital and general practice settings, in dressings as a treatment for external wounds, burns and ulcers. Nanosilver is also an increasingly important coating over embedded medical devices, inhibiting the development of biofilm. Nanosilver disinfectant sprays and polymer coatings are being widely promoted as protective against viral infections. In addition, nanosilver is widely used for its antibacterial properties in food processing and packaging, as well as in consumer products used for domestic cleaning and clothing. This article argues that medical devices, therapeutic products, and domestic food and goods containing nanosilver, although offering therapeutic benefits, must be subject to precautionary regulation owing to associated public health and environmental risks, particularly from large volumes of nanosilver in waste water. The article first examines the use of nanosilver in a variety of contemporary medical and domestic products, the utilization of which may assist in resolving global public health problems, such as restricted access to safe food, water and medical care. It then discusses the mechanisms of toxicity for nanosilver, whether it should be classified as a new chemical entity for regulatory purposes and whether its increased usage poses significant environmental and public health risks. The article next critically analyses representative international regulatory regimes (the USA, EU, UK and Australia) for medical and domestic use of nanosilver. The conclusion includes a set of recommendations for improving international regulation of nanosilver. PMID:20528456

  9. QA/QC issues to aid regulatory acceptance of microarray gene expression data.

    PubMed

    Fuscoe, James C; Tong, Weida; Shi, Leming

    2007-06-01

    The U.S. Food and Drug Administration is responsible for (1) promoting and protecting public health by assuring the safety and effectiveness of medicines and medical devices and (2) advancing public health by helping to speed innovations that make medicines and foods safer, more effective, and more affordable. The genomics revolution has dramatically increased our knowledge of basic biology but this has not resulted in the expected acceleration of new medical product development. The Agency's Critical Path to New Medical Products stresses that new tools are needed to address this pipeline problem. Microarray technology is one of these promising tools although questions have risen about the reproducibility of measurements. The Microarray Quality Control (MAQC) Project was initiated by FDA scientists to address this issue. This large project, which evaluated reference RNA samples on seven microarray platforms, found good intralaboratory repeatability and interlaboratory reproducibility. In addition, there was high cross-platform consistency. All data are available free of cost and the reference RNA samples are available for proficiency testing. Thus, current microarray technology appears to provide both reliability and consistency for regulatory submissions. PMID:17567852

  10. Addressing earthquake strong ground motion issues at the Idaho National Engineering Laboratory

    SciTech Connect

    Wong, I.G. ); Silva, W.J.; Stark, C.L. ); Jackson, S.; Smith, R.P. )

    1991-01-01

    In the course of reassessing seismic hazards at the Idaho National Engineering Laboratory (INEL), several key issues have been raised concerning the effects of the earthquake source and site geology on potential strong ground motions that might be generated by a large earthquake. The design earthquake for the INEL is an approximate moment magnitude (M{sub w}) 7 event that may occur on the southern portion of the Lemhi fault, a Basin and Range normal fault that is located on the northwestern boundary of the eastern Snake River Plain and the INEL, within 10 to 27km of several major facilities. Because the locations of these facilities place them at close distances to a large earthquake and generally along strike of the causative fault, the effects of source rupture dynamics (e.g., directivity) could be critical in enhancing potential ground shaking at the INEL. An additional source issue that has been addressed is the value of stress drop to use in ground motions predictions. In terms of site geology, it has been questioned whether the interbedded volcanic stratigraphy beneath the ESRP and the INEL attenuates ground motions to a greater degree than a typical rock site in the western US. These three issues have been investigated employing a stochastic ground motion methodology which incorporates the Band-Limited-White-Noise source model for both a point source and finite fault, random vibration theory and an equivalent linear approach to model soil response.

  11. Addressing earthquake strong ground motion issues at the Idaho National Engineering Laboratory

    SciTech Connect

    Wong, I.G.; Silva, W.J.; Stark, C.L.; Jackson, S.; Smith, R.P.

    1991-12-31

    In the course of reassessing seismic hazards at the Idaho National Engineering Laboratory (INEL), several key issues have been raised concerning the effects of the earthquake source and site geology on potential strong ground motions that might be generated by a large earthquake. The design earthquake for the INEL is an approximate moment magnitude (M{sub w}) 7 event that may occur on the southern portion of the Lemhi fault, a Basin and Range normal fault that is located on the northwestern boundary of the eastern Snake River Plain and the INEL, within 10 to 27km of several major facilities. Because the locations of these facilities place them at close distances to a large earthquake and generally along strike of the causative fault, the effects of source rupture dynamics (e.g., directivity) could be critical in enhancing potential ground shaking at the INEL. An additional source issue that has been addressed is the value of stress drop to use in ground motions predictions. In terms of site geology, it has been questioned whether the interbedded volcanic stratigraphy beneath the ESRP and the INEL attenuates ground motions to a greater degree than a typical rock site in the western US. These three issues have been investigated employing a stochastic ground motion methodology which incorporates the Band-Limited-White-Noise source model for both a point source and finite fault, random vibration theory and an equivalent linear approach to model soil response.

  12. Ethical and regulatory issues of pragmatic cluster randomized trials in contemporary health systems

    PubMed Central

    Anderson, Monique L; Califf, Robert M; Sugarman, Jeremy

    2015-01-01

    Cluster randomized trials (CRTs) randomly assign groups of individuals to examine research questions or test interventions and measure their effects on individuals. Recent emphasis on quality improvement, comparative effectiveness, and learning health systems has prompted expanded use of pragmatic CRTs in routine healthcare settings, which in turn poses practical and ethical challenges that current oversight frameworks may not adequately address. The 2012 Ottawa Statement provides a basis for considering many issues related to pragmatic CRTs but challenges remain, including some arising from the current U.S. research and healthcare regulations. In order to examine the ethical, regulatory, and practical questions facing pragmatic CRTs in healthcare settings, the National Institutes of Health (NIH) Health Care Systems Research Collaboratory convened a workshop in Bethesda, Maryland in July of 2013. Attendees included experts in clinical trials, patient advocacy, research ethics, and research regulations from academia, industry, the NIH, and other federal agencies. Workshop participants identified substantial barriers to implementing these types of CRTs, including issues related to research design, gatekeepers and governance in health systems, consent, institutional review boards, data monitoring, privacy, and special populations. We describe these barriers and suggest means for understanding and overcoming them to facilitate pragmatic CRTs in healthcare settings. PMID:25733677

  13. Athletics and Moral Development: Regulatory and Ethical Issues.

    ERIC Educational Resources Information Center

    Baldizan, Liz; Frey, James H.

    1995-01-01

    Using the Defining Issues Test, examined whether athletic participation enhances or detracts from moral development when female and male athletes (n=37) were compared with nonathletes (n=21) at a western university. Males scored lower than females and athletes tended to score lower than nonathletes. (JBJ)

  14. Clinical data and regulatory issues of biosimilar products.

    PubMed

    Stevenson, James G

    2015-12-01

    Biologics are a fast-growing segment of pharmaceutical development. Many are effective in the treatment of illnesses such as cancers, rheumatoid arthritis, and multiple sclerosis. Biologics encompass a range of compounds, including recombinant hormones, growth factors, monoclonal antibodies, recombinant vaccines, and blood products. Many of these drugs are facing patent expiration, and pharmaceutical research is focusing on the development of generic substitutes, or "biosimilars." Because biologics generally exhibit high molecular complexity, the process of development and approval of biosimilars is complicated. Unlike standard small molecule generics where an identical drug copy is expected, variations in biosimilars may be inherent because the sponsor does not have knowledge of the originator's processes. Because of this intricacy, regulatory requirements are needed to ensure biosimilarity, comparability, and interchangeability with respect to efficacy and safety. Clinician awareness of the similarities and differences between original biopharmaceuticals and biosimilars, as well as their impact on efficacy and safety, is imperative. PMID:26788808

  15. Overview of Variable Renewable Energy Regulatory Issues: A Clean Energy Regulators Initiative Report

    SciTech Connect

    Miller, M.; Cox, S.

    2014-05-01

    This CERI report aims to provide an introductory overview of key regulatory issues associated with the deployment of renewable energy -- particularly variable renewable energy (VRE) sources such wind and solar power. The report draws upon the research and experiences from various international contexts, and identifies key ideas that have emerged from the growing body of VRE deployment experience and regulatory knowledge. The report assumes basic familiarity with regulatory concepts, and although it is not written for a technical audience, directs the reader to further reading when available. VRE deployment generates various regulatory issues: substantive, procedural, and public interest issues, and the report aims to provide an empirical and technical grounding for all three types of questions as appropriate.

  16. Large system change challenges: addressing complex critical issues in linked physical and social domains

    NASA Astrophysics Data System (ADS)

    Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna

    2015-04-01

    Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways

  17. Afterschool: A Strategy for Addressing and Preventing Middle School Bullying. MetLife Foundation Afterschool Alert. Issue Brief No. 51

    ERIC Educational Resources Information Center

    Afterschool Alliance, 2011

    2011-01-01

    The Afterschool Alliance, in partnership with MetLife Foundation, is proud to present the second in a series of four issue briefs examining critical issues facing middle school youth and the vital role afterschool programs play in addressing these issues. This brief focuses on bullying awareness and prevention. Bullying is a dangerous behavior…

  18. Addressing the ethical, legal, and social issues raised by voting by persons with dementia.

    PubMed

    Karlawish, Jason H; Bonnie, Richard J; Appelbaum, Paul S; Lyketsos, Constantine; James, Bryan; Knopman, David; Patusky, Christopher; Kane, Rosalie A; Karlan, Pamela S

    2004-09-15

    This article addresses an emerging policy problem in the United States participation in the electoral process by citizens with dementia. At present, health care professionals, family caregivers, and long-term care staff lack adequate guidance to decide whether individuals with dementia should be precluded from or assisted in casting a ballot. Voting by persons with dementia raises a series of important questions about the autonomy of individuals with dementia, the integrity of the electoral process, and the prevention of fraud. Three subsidiary issues warrant special attention: development of a method to assess capacity to vote; identification of appropriate kinds of assistance to enable persons with cognitive impairment to vote; and formulation of uniform and workable policies for voting in long-term care settings. In some instances, extrapolation from existing policies and research permits reasonable recommendations to guide policy and practice. However, in other instances, additional research is necessary. PMID:15367557

  19. Closing the gaps in knowledge, policy and action to address water issues in forests

    NASA Astrophysics Data System (ADS)

    Adams, Paul W.

    1993-10-01

    Water issues on forest lands involve many human elements and needs that are not addressed by advanced physical and biological research and technology. Major gaps in our knowledge of important patterns of climate, soils, and terrain can be filled by relatively basic data collection and monitoring programs. Careful analysis of existing data and field experience also can reveal appropriate directions for management. A focus on problem-solving can direct research more effectively towards the resolution of key issues. Despite their impact, resource policies have widely varying scientific foundations. Policy-makers need sound processes for policy development, including timely technical input that is clear, objective, and related to socio-economic considerations. Resource polices should be consistent and include not only regulation, but also research, education, assistance, and incentives. Knowledge and sound policies still may not produce the desired on-the-ground actions, however, because of variable awareness, understanding, skill, or supervision in the field. Education and training programs are important not only for resource technicians, but also for contractors, operators, and other forest workers. Good planning, communication, and field coordination further insure that problems are avoided and new opportunities for effective actions are identified.

  20. Feasibility of a mindfulness-based intervention to address youth issues in Vietnam.

    PubMed

    Le, Thao N; Trieu, Don T

    2016-06-01

    Youth problems including risky sex, drug use, violence and mental health issues are on the rise in Vietnam. Mindfulness is proposed as one way to address unskillful responses to stress that give rise to these behavioral and psychosocial issues in Vietnam. This study explores the feasibility of a mindfulness program for adolescents and young adults in a central city in Vietnam. The mindfulness-based intervention was comprised 1-h daily session over 3 weeks that was conducted at two different sites, one with handicapped adolescents/young adults at the Vocational School for Handicapped and the other with at-risk youth at a semi-private high school. Forty-two Vietnamese youth participants and five Vietnamese teachers/facilitators who were trained in the mindfulness program provided personal reflections of their experiences. Analyses of the qualitative data suggest that mindfulness was enthusiastically received and accepted by both youth and teachers. There is strong indication that mindfulness is promising as a prevention strategy to help with stress and to build important life skills among Vietnamese youth. PMID:25452422

  1. Can Go address the multicore issues of today and the manycore problems of tomorrow?

    NASA Astrophysics Data System (ADS)

    Binet, Sébastien

    2012-06-01

    Current High Energy and Nuclear Physics (HENP) libraries and frameworks were written before multicore systems became widely deployed and used. From this environment, a 'single-thread' processing model naturally emerged but the implicit assumptions it encouraged are greatly impairing our abilities to scale in a multicore/manycore world. While parallel programming - still in an intensive phase of R&D despite the 30+ years of literature on the subject - is an obvious topic to consider, other issues (build scalability, code clarity, code deployment and ease of coding) are worth investigating when preparing for the manycore era. Moreover, if one wants to use another language than C++, a language better prepared and tailored for expressing concurrency, one also needs to ensure a good and easy reuse of already field-proven libraries. We present the work resulting from such investigations applied to the Go programming language. We first introduce the concurrent programming facilities Go is providing and how its module system addresses the build scalability and dependency hell issues. We then describe the process of leveraging the many (wo)man-years put into scientific Fortran/C/C++ libraries and making them available to the Go ecosystem. The ROOT data analysis framework, the C-BLAS library and the Herwig-6 MonteCarlo generator will be taken as examples. Finally, performances of the tools involved in a small analysis written in Go and using ROOT I/O library will be presented.

  2. Regulatory issues in cell-based therapy for clinical purposes.

    PubMed

    Casaroli-Marano, Ricardo P; Tabera, Jaime; Vilarrodona, Anna; Trias, Esteve

    2014-01-01

    Rapid development in the fields of cellular and molecular biology, biotechnology, and bioengineering medicine has brought new, highly innovative treatments and medicinal products, some of which contain viable cells and tissues associated with scaffolds and devices. These new cell-based therapy approaches in regenerative medicine have great potential for use in the treatment of a number of diseases that at present cannot be managed effectively. Given the unique challenges associated with the development of human cell-based medicinal products, great care is required in the development of procedures, practices, and regulation. In cell therapy, appropriate methodologies in the areas of production, reproducibility, maintenance, and delivery are essential for accurate definition and reliable assurance of the suitability and quality of the final products. Recently, the official European Community agencies (EMA) and the relevant authority in the USA (FDA) have made significant efforts to establish regulatory guidance for use in the application of the cell-based therapies for human patients. The guidelines surrounding cell-based therapy take into account the current legislation, but focus less on the heterogeneity and requirements of individual human cell-based products, including specific combination products and applications. When considering guidelines and regulation, a risk assessment approach is an effective method of identifying priority areas for the development of human cell-based medicinal products. Additionally, effective design and thorough validation of the manufacturing process in line with existing Good Manufacturing Practices (GMPs) and quality control regimes and a program that ensures the traceability and biovigilance of the final products are also all essential elements to consider. PMID:24732772

  3. Progress in Addressing DNFSB Recommendation 2002-1 Issues: Improving Accident Analysis Software Applications

    SciTech Connect

    VINCENT, ANDREW

    2005-04-25

    Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2002-1 (''Quality Assurance for Safety-Related Software'') identified a number of quality assurance issues on the use of software in Department of Energy (DOE) facilities for analyzing hazards, and designing and operating controls to prevent or mitigate potential accidents. Over the last year, DOE has begun several processes and programs as part of the Implementation Plan commitments, and in particular, has made significant progress in addressing several sets of issues particularly important in the application of software for performing hazard and accident analysis. The work discussed here demonstrates that through these actions, Software Quality Assurance (SQA) guidance and software tools are available that can be used to improve resulting safety analysis. Specifically, five of the primary actions corresponding to the commitments made in the Implementation Plan to Recommendation 2002-1 are identified and discussed in this paper. Included are the web-based DOE SQA Knowledge Portal and the Central Registry, guidance and gap analysis reports, electronic bulletin board and discussion forum, and a DOE safety software guide. These SQA products can benefit DOE safety contractors in the development of hazard and accident analysis by precluding inappropriate software applications and utilizing best practices when incorporating software results to safety basis documentation. The improvement actions discussed here mark a beginning to establishing stronger, standard-compliant programs, practices, and processes in SQA among safety software users, managers, and reviewers throughout the DOE Complex. Additional effort is needed, however, particularly in: (1) processes to add new software applications to the DOE Safety Software Toolbox; (2) improving the effectiveness of software issue communication; and (3) promoting a safety software quality assurance culture.

  4. Warren K. Sinclair keynote address: contemporary issues in risk-informed decision making on the disposition of radioactive waste.

    PubMed

    Garrick, B John

    2006-11-01

    A consistent and transparent risk-informed approach to managing nuclear waste is plagued with different regulators, different rules and regulations for different waste types, different compliance requirements, and indecisions about probabilistic vs. deterministic models. Low-activity waste management is particularly void of a path forward with respect to being risk-informed. Risk assessment is not referenced in the statutes on low-activity waste even though both the U.S. Environmental Protection Agency and U.S. Nuclear Regulatory Commission (U.S. NRC) have policies to apply consistent risk management approaches to all of their programs. The U.S. NRC has developed guidance on the preparation of probabilistic performance assessments for low-activity waste facilities, but there have been no serious takers and a lack of initiative on the part of licensees. Thus, little to no experience exists on risk-informing low-activity waste. The missed opportunities include establishing a risk basis that would allow for simpler, safer, and much less costly alternatives for low-activity waste disposal while enabling society to have the full benefit of radiation technologies. There is hope that congressional action or regulatory rule making will address some of these issues with the result being the adoption of a more general and unified approach to risk-informed regulation of all types of waste. Just as much of the initiative for risk-informed nuclear power came from industry, it must also be the case for nuclear waste. A start would be the adoption of a basic framework of risk assessment in waste management applicable to all types of waste--radioactive and nonradioactive. The "set of triplets" risk assessment framework that is applicable to any kind of risk is an established alternative. It is believed that such a framework with the support of a regulatory structure made compatible through appropriate rulemaking or congressional action, and the experience of the probabilistic

  5. Levothyroxine: therapeutic use and regulatory issues related to bioequivalence.

    PubMed

    Wartofsky, Leonard

    2002-06-01

    Levothyroxine is the overwhelming choice of clinicians for the treatment of hypothyroidism and for the suppression of goitre and thyroid nodules in selected cases. The monitoring of serum levels of thyroid stimulating hormone is necessary for appropriate dosage adjustment of levothyroxine. Levothyroxine has a narrow therapeutic index: both underdosage (subclinical hypothyroidism) and excessive dosage (subclinical hyperthyroidism) are associated with adverse symptoms and pathophysiological effects and are to be avoided. The consequent necessity for careful titration of doses has had an impact on the issue of switchability, or bioequivalence, of the various marketed levothyroxine products. In this article, the basis for concern about currently accepted standards of the FDA for pharmacological bioequivalence are examined in the context of levothyroxine. The history and status of the recent request by the FDA for a new drug application for all levothyroxine products, and its impact on the market leader Synthroid, is also discussed. PMID:12036412

  6. Regulatory framework in assisted reproductive technologies, relevance and main issues.

    PubMed

    Merlet, Françoise

    2009-01-01

    Assisted reproductive technologies (ART) have changed life for the past 25 years and many ethical and social issues have emerged following this new method of conception. In order to protect individuals against scientific and ethical abuses without inhibiting scientific progress, a specific legal framework is necessary. The first French law on Bioethics was voted after an extensive debate in 1994 then reviewed in 2004. This review previously scheduled every five years is currently being discussed. Legal provisions applying to ART are part of a large framework including the protection of the patients' rights and biomedical research. The key principles consist of respect for human life and ban on commercial practices of human body parts, eugenic practices and any kind of cloning. These key principles apply to ART. Donation is anonymous and free. Created in 2004, the Agence de la biomédecine is a government agency and one of the main tools of the French regulations. The missions focus on improving the quality and the safety of the management of ART. Evaluation of activities is available to all from the annual report. The agency represents the French competent authority for medical and scientific aspects of ART. Substantial differences in European legislations exist from the open-up "laissez faire" to the most restrictive one. As a consequence a large reproductive tourism has developed particularly for egg donation or surrogacy. The medical and ethical conditions of management of patients and donors represent the main critical points. In order to avoid ethical abuses, homogenization regarding the key principles is necessary in Europe. It is an opportunity to reassert that human body parts should not be a source of financial gain. PMID:20067901

  7. Addressing Issues of Broadening Participation Highlighted in the Report on the Future of Undergraduate Geoscience Education

    NASA Astrophysics Data System (ADS)

    McDaris, J. R.; Manduca, C. A.; Macdonald, H.; Iverson, E. A. R.

    2015-12-01

    The final report for the Summit on the Future of Geoscience Education lays out a consensus on issues that must be tackled by the geoscience community collectively if there are to be enough qualified people to fill the large number of expected geoscience job vacancies over the coming decade. Focus areas cited in the report include: Strengthening the connections between two-year colleges and four-year institutions Sharing and making use of successful recruitment and retention practices for students from underrepresented groups Making students aware of high-quality job prospects in the geosciences as well as its societal relevance The InTeGrate STEP Center for the Geosciences, the Supporting and Advancing Geoscience Education at Two-Year Colleges (SAGE 2YC) program, and the Building Strong Geoscience Departments (BSGD) project together have developed a suite of web resources to help faculty and program leaders begin to address these and other issues. These resources address practices that support the whole student, both in the classroom and as a part of the co-curriculum as well as information on geoscience careers, guidance for developing coherent degree programs, practical advice for mentoring and advising, and many others. In addition to developing web resources, InTeGrate has also undertaken an effort to profile successful program practices at a variety of institutions. An analysis of these data shows several common themes (e.g. proactive marketing, community building, research experiences) that align well with the existing literature on what works to support student success. But there are also indications of different approaches and emphases between Minority Serving Institutions (MSIs) and Primarily White Institutions (PWIs) as well as between different kinds of MSIs. Highlighting the different strategies in use can point both MSIs and PWIs to possible alternate solutions to the challenges their students face. InTeGrate - http

  8. The National Academy of Sciences offers a new framework for addressing global warming issues.

    PubMed

    Barnard, R C; Morgan, D L

    2000-02-01

    The recent landmark report by the National Academy of Sciences reviewed the science on which the Kyoto Protocol was based. NAS concluded that the policy choices and the mandatory reductions in greenhouse gases by the developed nations were based on incomplete science with significant uncertainties. In view of these uncertainties the NAS report developed a comprehensive strategic 10-year research program to address the basic issue of whether human activity that results in environmental changes is responsible for climate changes. The report provides a new framework for consideration of global warming issues. The UN International Panel on Climate Change (the UN science advisor) in its 1997 report to the Kyoto parties pointed out the confusing difference between scientific usage of the term "climate change" that distinguishes human from natural causes of change and the official usage that combines natural and human causes of changes in climate. The conclusion of the UN panel on human causes is equivocal. The 1999 report of the U.S. Global Science Research Committee also reached an equivocal conclusion on human causes and announced a 10-year research program to be developed in consultation with NAS. The precautionary measures provided in the 1992 UN Framework Convention differ from the ill-defined "precautionary principle" based on fear of uncertainty, and are consistent with the objectives of the NAS proposed research program. These developments together with the third report of the UN Intergovernmental Science Panel on developments in climate science due in 2001 merit consideration by the convention of the parties under the Kyoto Protocol. PMID:10715229

  9. Legal and regulatory issues affecting the aquifer thermal energy storage concept

    SciTech Connect

    Hendrickson, P.L.

    1980-10-01

    A number of legal and regulatory issus that potentially can affect implementation of the Aquifer Thermal Energy Storage (ATES) concept are examined. This concept involves the storage of thermal energy in an underground aquifer until a later date when it can be effectively utilized. Either heat energy or chill can be stored. Potential end uses of the energy include district space heating and cooling, industrial process applications, and use in agriculture or aquaculture. Issues are examined in four categories: regulatory requirements, property rights, potential liability, and issues related to heat or chill delivery.

  10. When Academic Assistance Is Not Enough: Addressing the Mental Health Issues of Adolescents and Adults with Learning Disabilities.

    ERIC Educational Resources Information Center

    Price, Lynda A.; And Others

    1994-01-01

    This article addresses theoretical and practical issues in the provision of mental health services to address psychosocial problems of secondary and postsecondary students with learning disabilities. Examples are offered of case studies and interventions from two federally funded research/demonstration projects at the University of Minnesota: the…

  11. A modular approach to addressing model design, scale, and parameter estimation issues in distributed hydrological modelling

    NASA Astrophysics Data System (ADS)

    Leavesley, G. H.; Markstrom, S. L.; Restrepo, P. J.; Viger, R. J.

    2002-02-01

    A modular approach to model design and construction provides a flexible framework in which to focus the multidisciplinary research and operational efforts needed to facilitate the development, selection, and application of the most robust distributed modelling methods. A variety of modular approaches have been developed, but with little consideration for compatibility among systems and concepts. Several systems are proprietary, limiting any user interaction. The US Geological Survey modular modelling system (MMS) is a modular modelling framework that uses an open source software approach to enable all members of the scientific community to address collaboratively the many complex issues associated with the design, development, and application of distributed hydrological and environmental models. Implementation of a common modular concept is not a trivial task. However, it brings the resources of a larger community to bear on the problems of distributed modelling, provides a framework in which to compare alternative modelling approaches objectively, and provides a means of sharing the latest modelling advances. The concepts and components of the MMS are described and an example application of the MMS, in a decision-support system context, is presented to demonstrate current system capabilities.

  12. A modular approach to addressing model design, scale, and parameter estimation issues in distributed hydrological modelling

    USGS Publications Warehouse

    Leavesley, G.H.; Markstrom, S.L.; Restrepo, P.J.; Viger, R.J.

    2002-01-01

    A modular approach to model design and construction provides a flexible framework in which to focus the multidisciplinary research and operational efforts needed to facilitate the development, selection, and application of the most robust distributed modelling methods. A variety of modular approaches have been developed, but with little consideration for compatibility among systems and concepts. Several systems are proprietary, limiting any user interaction. The US Geological Survey modular modelling system (MMS) is a modular modelling framework that uses an open source software approach to enable all members of the scientific community to address collaboratively the many complex issues associated with the design, development, and application of distributed hydrological and environmental models. Implementation of a common modular concept is not a trivial task. However, it brings the resources of a larger community to bear on the problems of distributed modelling, provides a framework in which to compare alternative modelling approaches objectively, and provides a means of sharing the latest modelling advances. The concepts and components of the MMS are described and an example application of the MMS, in a decision-support system context, is presented to demonstrate current system capabilities. Copyright ?? 2002 John Wiley and Sons, Ltd.

  13. 32 CFR Appendix C to Part 22 - Administrative Requirements and Issues To Be Addressed in Award Terms and Conditions

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Administrative Requirements and Issues To Be Addressed in Award Terms and Conditions C Appendix C to Part 22 National Defense Department of Defense... AND ADMINISTRATION Pt. 22, App. C Appendix C to Part 22—Administrative Requirements and Issues To...

  14. 32 CFR Appendix C to Part 22 - Administrative Requirements and Issues To Be Addressed in Award Terms and Conditions

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Administrative Requirements and Issues To Be Addressed in Award Terms and Conditions C Appendix C to Part 22 National Defense Department of Defense... AND ADMINISTRATION Pt. 22, App. C Appendix C to Part 22—Administrative Requirements and Issues To...

  15. 32 CFR Appendix C to Part 22 - Administrative Requirements and Issues To Be Addressed in Award Terms and Conditions

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Administrative Requirements and Issues To Be Addressed in Award Terms and Conditions C Appendix C to Part 22 National Defense Department of Defense... AND ADMINISTRATION Pt. 22, App. C Appendix C to Part 22—Administrative Requirements and Issues To...

  16. Earthquake Seismic Risk Reduction in Ohio: ODNR's Efforts to Address Issues with Natural and Induced Seismicity

    NASA Astrophysics Data System (ADS)

    Besana-Ostman, G. M.

    2013-05-01

    With the increasing concerns regarding both natural and induced seismicity in Ohio, ODNR (Ohio Department of Natural Resources) initial efforts on seismic risk reduction paved way to various changes and improvement to tackle several major issues. For natural earthquakes, regional seismicity indicates a NE-SW structure in the northern portion of the area associated with a number of moderate historical earthquakes but no active trace identified. On the other hand, earthquakes of 1986 and 2011 are most probably incidents of induced seismicity that trigger more public uproar against disposal of regulated waste waters through injections. ODNR, in efforts to adapt with increasing need to regulate all operations related to both the Utica and Marcellus shale play within the state, had recently strengthen itself both through additional human resources and improved infrastructure. Tougher regulations and additional field tests were required that took effect immediately when a M4 earthquake was associated with the operations of an injection well. Public meetings were undertaken focused on educating many local inhabitants related to oil and gas operations, hydraulic fracturing, injection wells, and seismicity. Trainings for new and existing staff were regularly done especially for field inspection, data management and technology advancements. Considering the existing seismic stations that are few and distant related to sites of the injection wells, additional seismic stations were installed to gather baseline data and monitor for earthquakes within the injection area(s). Furthermore, to assess if the sites of the injection wells are safe from active structures, initial geomorphic and structural analyses indicated possible active faults in the northern portion of state oriented NE-SW. With the above-mentioned recent changes, ODNR had made a significant leap not only in the improvement of its principal regulatory role in the state for oil and gas operations but also in its

  17. Rewarding altruism: addressing the issue of payments for volunteers in public health initiatives.

    PubMed

    South, Jane; Purcell, Martin E; Branney, Peter; Gamsu, Mark; White, Judy

    2014-03-01

    Lay involvement in public health programmes occurs through formalised lay health worker (LHW) and other volunteer roles. Whether such participation should be supported, or indeed rewarded, by payment is a critical question. With reference to policy in England, UK, this paper argues how framing citizen involvement in health only as time freely given does not account for the complexities of practice, nor intrinsic motivations. The paper reports results on payment drawn from a study of approaches to support lay people in public health roles, conducted in England, 2007-9. The first phase of the study comprised a scoping review of 224 publications, three public hearings and a register of projects. Findings revealed the diversity of approaches to payment, but also the contested nature of the topic. The second phase investigated programme support matters in five case studies of public health projects, which were selected primarily to reflect role types. All five projects involved volunteers, with two utilising forms of payment to support engagement. Interviews were conducted with a sample of project staff, LHWs (paid and unpaid), external partners and service users. Drawing on both lay and professional perspectives, the paper explores how payment relates to social context as well as various motivations for giving, receiving or declining financial support. The findings show that personal costs are not always absorbed, and that there is a potential conflict between financial support, whether sessional payment or expenses, and welfare benefits. In identifying some of the advantages and disadvantages of payment, the paper highlights the complexity of an issue often addressed only superficially. It concludes that, in order to support citizen involvement, fairness and value should be considered alongside pragmatic matters of programme management; however policy conflicts need to be resolved to ensure that employment and welfare rights are maintained. PMID:24581065

  18. Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals

    PubMed Central

    Dugas, Tammy R.; Lomnicki, Slawomir; Cormier, Stephania A.; Dellinger, Barry; Reams, Margaret

    2016-01-01

    Airborne fine and ultrafine particulate matter (PM) are often generated through widely-used thermal processes such as the combustion of fuels or the thermal decomposition of waste. Residents near Superfund sites are exposed to PM through the inhalation of windblown dust, ingestion of soil and sediments, and inhalation of emissions from the on-site thermal treatment of contaminated soils. Epidemiological evidence supports a link between exposure to airborne PM and an increased risk of cardiovascular and pulmonary diseases. It is well-known that during combustion processes, incomplete combustion can lead to the production of organic pollutants that can adsorb to the surface of PM. Recent studies have demonstrated that their interaction with metal centers can lead to the generation of a surface stabilized metal-radical complex capable of redox cycling to produce ROS. Moreover, these free radicals can persist in the environment, hence their designation as Environmentally Persistent Free Radicals (EPFR). EPFR has been demonstrated in both ambient air PM2.5 (diameter < 2.5 µm) and in PM from a variety of combustion sources. Thus, low-temperature, thermal treatment of soils can potentially increase the concentration of EPFR in areas in and around Superfund sites. In this review, we will outline the evidence to date supporting EPFR formation and its environmental significance. Furthermore, we will address the lack of methodologies for specifically addressing its risk assessment and challenges associated with regulating this new, emerging contaminant. PMID:27338429

  19. Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals.

    PubMed

    Dugas, Tammy R; Lomnicki, Slawomir; Cormier, Stephania A; Dellinger, Barry; Reams, Margaret

    2016-01-01

    Airborne fine and ultrafine particulate matter (PM) are often generated through widely-used thermal processes such as the combustion of fuels or the thermal decomposition of waste. Residents near Superfund sites are exposed to PM through the inhalation of windblown dust, ingestion of soil and sediments, and inhalation of emissions from the on-site thermal treatment of contaminated soils. Epidemiological evidence supports a link between exposure to airborne PM and an increased risk of cardiovascular and pulmonary diseases. It is well-known that during combustion processes, incomplete combustion can lead to the production of organic pollutants that can adsorb to the surface of PM. Recent studies have demonstrated that their interaction with metal centers can lead to the generation of a surface stabilized metal-radical complex capable of redox cycling to produce ROS. Moreover, these free radicals can persist in the environment, hence their designation as Environmentally Persistent Free Radicals (EPFR). EPFR has been demonstrated in both ambient air PM2.5 (diameter < 2.5 µm) and in PM from a variety of combustion sources. Thus, low-temperature, thermal treatment of soils can potentially increase the concentration of EPFR in areas in and around Superfund sites. In this review, we will outline the evidence to date supporting EPFR formation and its environmental significance. Furthermore, we will address the lack of methodologies for specifically addressing its risk assessment and challenges associated with regulating this new, emerging contaminant. PMID:27338429

  20. A Consideration to Two Main Ethical Issues in Educational Research, and How May These Be Addressed

    ERIC Educational Resources Information Center

    Abed, Mohaned Ghazi

    2015-01-01

    This paper has firstly discussed the topic of Ethical Issues in Education, and has accordingly highlighted the fact that ethics are not something to deem at the commencement of a research project or fieldwork, but rather throughout the entire research process. Furthermore, two of the most important ethical issues have been given…

  1. Pursuing Justice for Refugee Students: Addressing Issues of Cultural (Mis)Recognition

    ERIC Educational Resources Information Center

    Keddie, Amanda

    2012-01-01

    In this paper Nancy Fraser's conceptual tools are drawn on to theorise issues of justice in a culturally diverse primary school in Australia where approximately 30% of the student population are immigrant/refugees. The paper examines justice issues of cultural recognition in relation to refugee student identity, behaviour and assessment. Drawing…

  2. 18 CFR 2.1a - Public suggestions, comments, proposals on substantial prospective regulatory issues and problems.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., comments, proposals on substantial prospective regulatory issues and problems. 2.1a Section 2.1a... problems. (a) The Commission by this policy statement explicitly encourages the public, including those... substantial prospective regulatory policy issues and problems, the resolution of which will have a...

  3. 18 CFR 2.1a - Public suggestions, comments, proposals on substantial prospective regulatory issues and problems.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., comments, proposals on substantial prospective regulatory issues and problems. 2.1a Section 2.1a... problems. (a) The Commission by this policy statement explicitly encourages the public, including those... substantial prospective regulatory policy issues and problems, the resolution of which will have a...

  4. 2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections.

    PubMed

    Garofolo, Fabio; Rocci, Mario L; Dumont, Isabelle; Martinez, Suzanne; Lowes, Steve; Woolf, Eric; van Amsterdam, Peter; Bansal, Surendra; Barra, Ariadna Cristina Gomes; Bauer, Ronald; Booth, Brian P; Carrasco-Triguero, Montserrat; DeSilva, Binodh; Dunn, John; Gallicano, Keith; Gouty, Dominique; Ho, Stacy; Hucker, Richard; Jemal, Mohammed; Katori, Noriko; Le Blaye, Olivier; Lee, Jean; Li, Wenkui; Michael, Steve; Nehls, Corey; Nicholson, Robert; Ormsby, Eric; Tang, Daniel; Viswanathan, C T; Weiner, Russell; Young, Graeme

    2011-09-01

    The 5th Workshop on Recent Issues in Bioanalysis (WRIB) was organized by the Calibration and Validation Group as a 2-day full immersion workshop for pharmaceutical companies, CROs and regulatory agencies to discuss, review, share perspectives, provide potential solutions and agree upon a consistent approach to recent issues in the bioanalysis of both small and large molecules. High quality, better compliance to regulations and scientific excellence are the foundation of this workshop. As in the previous editions of this significant event, recommendations were made and a consensus was reached among panelists and attendees, including industry leaders and regulatory experts representing the global bioanalytical community, on many 'hot' topics in bioanalysis. This 2011 White Paper is based on the conclusions from this workshop, and aims to provide a practical reference guide on those topics. PMID:21942519

  5. Dilemmas with Dilemmas...Exploring the Suitability of Dilemma Stories as a Way of Addressing Ethical Issues in Science Education.

    ERIC Educational Resources Information Center

    Settelmaier, Elisabeth

    Traditionally, many science educators have taught science without addressing ethical questions. However, the inclusion of moral discourse in science teaching may help educators to bring to the fore problematic issues in relation to science, and it may offer an opportunity for students to practice their future engagement in the public discourse…

  6. Core Issues that Must be Addressed in Order to Improve Vocational Education and Training in Indonesia. An Institutional Analysis

    ERIC Educational Resources Information Center

    Cully, John H.

    2007-01-01

    Indonesia, like many other countries has to come to terms with the challenges of a rapidly advancing economic globalization. In order to address the major issues involved the government must take some very essential steps that are practical, attainable and sustainable. With global economies evolving from a traditional resource structure to that of…

  7. Teaching for Change: Addressing Issues of Difference in the College Classroom. Reprint Series No. 25. Harvard Educational Review.

    ERIC Educational Resources Information Center

    Geismar, Kathryn, Ed.; Nicoleau, Guitele, Ed.

    Contributors to this collection of essays describe how they address issues of race, gender, and class in their college courses as they attempt to ensure that their curricula and class discussions represent the perspectives of all students. Essays include: (1) "Introduction" (Kathryn Giesmar and Guitele Nicoleau); (2) "Dialogue across Differences:…

  8. ISSUES THAT MUST BE ADDRESSED FOR RISK ASSESSMENT OF MIXED EXPOSURES: THE EPA EXPERIENCE WITH AIR QUALITY

    EPA Science Inventory

    Issues that Must be Addressed for Risk Assessment of Mixed Exposures: The EPA Experience with Air Quality

    Daniel L. Costa, Sc.D.

    Abstract
    Humans are routinely exposed to a complex mixture of air pollutants in both their outdoor and indoor environments. The wide...

  9. Encouraging Pre-Service Teachers to Address Issues of Sexual Orientation in Their Classrooms: Walking the Walk & Talking the Talk

    ERIC Educational Resources Information Center

    Hansen, Laurie E.

    2015-01-01

    The purpose of this article is to describe ways that teacher educators can encourage future teachers to address lesbian, gay, bisexual, or transgender (LGBT) issues in their own classrooms. The Gay, Lesbian, Straight Education Network's ThinkB4YouSpeak Educator's Guide served as the framework for the activities that the author has implemented in…

  10. The Constellation-EdF nuclear joint venture: regulatory issues and subsequent resolutions

    SciTech Connect

    Pfaff, Ryan; Lubow, Howard; Malko, J. Robert

    2010-03-15

    Corporate restructurings of electric utilities in the U.S. have become a significant and controversial issue due to the differing perspectives of electric utility executives and regulatory commissioners relating to corporate restructuring associated with mergers, diversification, and functional separation of generation, transmission, and distribution. The Maryland Public Service Commission assessed a joint venture between Constellation Energy Group and Electricite de France that reflects these tradeoffs. (author)

  11. 2016 State of the State Addresses: Governors' Top Education Issues. Education Trends

    ERIC Educational Resources Information Center

    Auck, Alyssa; Railey, Hunter

    2016-01-01

    Each year, governors take the stage to highlight accomplishments and outline policy priorities for their states. In an effort to provide up-to-date information on education policy trends, Education Commission of the States tracks all education policy proposals and accomplishments featured by governors in these State of the State addresses. At the…

  12. Afterschool in Action: How Innovative Afterschool Programs Address Critical Issues Facing Middle School Youth

    ERIC Educational Resources Information Center

    Afterschool Alliance, 2012

    2012-01-01

    Over the last four years, the Afterschool Alliance and MetLife Foundation have worked together to identify exemplary, and often lesser-known afterschool programs across the nation. For the past two years, efforts have focused on finding innovative afterschool programs serving middle school students. This focus was developed to address the need for…

  13. Addressing Air, Land & Water Nitrogen Issues under Changing Climate Trends & Variability

    EPA Science Inventory

    The climate of western U.S. dairy producing states is anticipated to change significantly over the next 50 to 75 years. A multimedia modeling system based upon the “nitrogen cascade” concept has been configured to address three aspects of sustainability (environmenta...

  14. Open Lives, Safe Schools: Addressing Gay and Lesbian Issues in Education.

    ERIC Educational Resources Information Center

    Walling, Donovan R., Ed.

    In all but a handful of states, it is legal to discriminate against individuals on the basis of sexual orientation. Ways in which homophobia and anti-gay sentiments affect education in the United States are addressed in this collection of essays. They are written for educators and others concerned about schooling, from kindergarten through…

  15. Use of Social Software to Address Literacy and Identity Issues in Second Language Learning

    ERIC Educational Resources Information Center

    Hutchinson, Jill

    2009-01-01

    The emerging trend of social software technology can address many different second language (L2) learner needs through authentic social interaction and a variety of scaffolding processes. Social software connects education with real-life learning and interests, and engages and motivates students. It can facilitate learning environments that are…

  16. Teaching Water: Connecting across Disciplines and into Daily Life to Address Complex Societal Issues

    ERIC Educational Resources Information Center

    Eisen, Arri; Hall, Anne; Lee, Tong Soon; Zupko, Jack

    2009-01-01

    A central problem in higher education is how to best develop in students interdisciplinary thinking and application skills necessary to work and engage effectively in the twenty-first century. Traditional university structures make addressing this problem especially challenging. Using as a model courses with diverse perspectives on water taught by…

  17. Bridging the Gap: Essential Issues to Address in Recurring Writing Center Appointments with Chinese ELL Students

    ERIC Educational Resources Information Center

    Nan, Frances

    2012-01-01

    As the population of international--and particularly Chinese--students grows in US academic institutions, it is critical that writing center tutors be able to address these students' needs. However, whereas writing tutors at the author's institution are often taught to be indirect and focus on higher order concerns, such strategies are not always…

  18. Governors' Top Education Issues: 2015 State of the State Addresses. ECS Education Trends

    ERIC Educational Resources Information Center

    Aragon, Stephanie; Rowland, Julie

    2015-01-01

    Education Commission of the States (ECS) strives to keep its constituency apprised of education policy trends across the states. To provide a comprehensive overview of educational priorities outlined by governors, ECS summarized the education proposals and accomplishments detailed in every 2015 State of the State address delivered to date. Each…

  19. Standards, Assessment, and Readiness: Addressing Postsecondary Transition Issues across State Lines

    ERIC Educational Resources Information Center

    Michelau, Demarée K.

    2015-01-01

    This brief describes major challenges ahead for states, institutions, and most importantly, students as the standards and assessments from the Common Core Standards (CCSS) are implemented. It also offers recommendations to create a network structure that would assist K-12 and higher education leaders in addressing those challenges. To begin the…

  20. Addressing Agricultural Issues in Health Care Education: An Occupational Therapy Curriculum Program Description

    ERIC Educational Resources Information Center

    Smallfield, Stacy; Anderson, Angela J.

    2008-01-01

    Context: Medical and allied health professionals who work in agricultural states frequently address the needs of clients who live and work in rural and frontier environments. The primary occupations of those living in rural areas include farming, ranching, or other agriculture-related work. Farming is consistently ranked as one of the most…

  1. Ghost Surgery: A Frank Look at the Issue and How to Address It.

    PubMed

    Dunn, Debra

    2015-12-01

    Ghost surgery occurs when a physician assistant, a surgical assistant, an RN first assistant, a resident, or another surgeon assists on or performs an operative or other invasive procedure without the patient's knowledge, regardless of whether the surgeon who obtained the consent was scrubbed in or not. This practice denies patients important information, eliminates their ability to provide informed consent, and represents an ethical issue that nurses must deal with when working with peers and patients. The American Nurses Association developed the Code of Ethics for Nurses to help guide nursing practice, and the provisions within the code embody the ethical issues that should guide nurses' practice in advocating for patients. PMID:26616321

  2. School-Based Programs Addressing Gay/Lesbian/Bisexual Youth Issues.

    ERIC Educational Resources Information Center

    Rienzo, Barbara A.; And Others

    1997-01-01

    Homosexual adolescents are at risk within schools for many health problems. Hostile school environments can often exacerbate their problems. This article summarizes research on issues related to youth sexual orientation, noting controversies surrounding school involvement in the United States and describing programs instituted by school…

  3. A Critical Look at Physical Education and What Must Be Done to Address Obesity Issues

    ERIC Educational Resources Information Center

    Prusak, Keven; Graser, Susan Vincent; Pennington, Todd; Zanandrea, Maria; Wilkinson, Carol; Hager, Ron

    2011-01-01

    Historically, physical education (PE) has been designed to do one thing--teach sport skills. However, it is now being asked to deal with lifestyle issues such as obesity and inactivity. Since the target and purposes of PE have changed, a fundamental shift in the way it is delivered is essential to its survival. This article highlights some…

  4. Where We Live: A Curriculum Guide. ABE Materials that Address Housing Issues.

    ERIC Educational Resources Information Center

    Ellowitch, Azi

    This curriculum was developed to give adult basic education (ABE) teachers starting points for developing their own units around housing-related issues. The texts have been chosen thematically, rather than by skill level. The materials are designed for group work--oral reading and discussion. Readings focus on housing repairs, court procedures,…

  5. History Museums and Social Cohesion: Building Identity, Bridging Communities, and Addressing Difficult Issues

    ERIC Educational Resources Information Center

    Rosenberg, Tracy Jean

    2011-01-01

    Museums have the capacity to enhance social cohesion, which is the product of a trusting, connected community. History museums and historic sites, in particular, can serve communities by stimulating dialogue on difficult issues, accurately representing all the people of a nation, and creating forums for discussion among groups with disparate…

  6. Science Teachers' Use of Mass Media to Address Socio-Scientific and Sustainability Issues

    ERIC Educational Resources Information Center

    Klosterman, Michelle L.; Sadler, Troy D.; Brown, Julie

    2012-01-01

    The currency, relevancy and changing nature of science makes it a natural topic of focus for mass media outlets. Science teachers and students can capitalize on this wealth of scientific information to explore socio-scientific and sustainability issues; however, without a lens on how those media are created and how representations of science are…

  7. The Role of Sexual Trauma in the Treatment of Chemically Dependent Women: Addressing the Relapse Issue.

    ERIC Educational Resources Information Center

    Wadsworth, Rick; And Others

    1995-01-01

    Explores issues surrounding sexual trauma and chemical dependency. Aims to provide direction for relapse prevention with a relapse-prone population and explores application of traditional milieu substance-abuse treatment for sexual-trauma survivors. Makes recommendations for working with sexual-trauma survivors who are also substance abusers. (RJM)

  8. Skirting the Issue: Teachers' Experiences "Addressing Sexuality in Middle School Language Arts"

    ERIC Educational Resources Information Center

    Puchner, Laurel; Klein, Nicole Aydt

    2012-01-01

    The goal of this study was to examine perceptions, attitudes, and reported practices of a group of middle level Language Arts teachers concerning sexuality-related issues. Through interviews with 15 teachers, the study found that sexuality was in one sense pervasive, as it came up frequently in the teachers' practice. Yet at the same time the…

  9. Contemporary Issues on Campuses: Today's Activities Professionals Must Address Everything from AIDS Education to Crime Prevention.

    ERIC Educational Resources Information Center

    Scopes, Jack

    1990-01-01

    Some approaches to dealing with contemporary issues on campus include Acquired Immune Deficiency Syndrome awareness--safe sex parties; crime prevention--students helping students, legislation, workshops and conferences; alcohol awareness--designated driver program and starting a nonalcoholic bar; cults on campus; sexual assault--"Hours Til…

  10. Extending Transition to Address Guardianship Alternatives: An Issue Concerning Students Who Have Intellectual Disability

    ERIC Educational Resources Information Center

    Millar, Dorothy Squatrito

    2014-01-01

    As students who have intellectual disability reach or have reached the age of majority, concerns regarding their competence to make informed decisions are often raised, as is the issue of adult guardianship. Guardianship refers to when a judge appoints an adult to be the guardian of another adult (ward) who has been determined to be unable to care…

  11. Progression in Ethical Reasoning When Addressing Socio-Scientific Issues in Biotechnology

    ERIC Educational Resources Information Center

    Berne, Birgitta

    2014-01-01

    This article reports on the outcomes of an intervention in a Swedish school in which the author, a teacher-researcher, sought to develop students' (14-15 years old) ethical reasoning in science through the use of peer discussions about socio-scientific issues. Prior to the student discussions various prompts were used to highlight different…

  12. 2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 2 - hybrid LBA/LCMS and input from regulatory agencies).

    PubMed

    Ackermann, Brad; Neubert, Hendrik; Hughes, Nicola; Garofolo, Fabio; Abberley, Lee; Alley, Stephen C; Brown-Augsburger, Patricia; Bustard, Mark; Chen, Lin-Zhi; Heinrich, Julia; Katori, Noriko; Kaur, Surinder; Kirkovsky, Leo; Laterza, Omar F; Le Blaye, Olivier; Lévesque, Ann; Santos, Gustavo Mendes Lima; Olah, Timothy; Savoie, Natasha; Skelly, Michael; Spitz, Susan; Szapacs, Matthew; Tampal, Nilufer; Wang, Jian; Welink, Jan; Wieling, Jaap; Haidar, Sam; Vinter, Stephen; Whale, Emma; Witte, Bärbel

    2015-12-01

    The 2015 9th Workshop on Recent Issues in Bioanalysis (9th WRIB) took place in Miami, Florida with participation of over 600 professionals from pharmaceutical and biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. It is once again a 5-day week long event - a full immersion bioanalytical week - specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest in bioanalysis. The topics covered included both small and large molecules, and involved LCMS, hybrid LBA/LCMS, LBA approaches including the focus on biomarkers and immunogenicity. This 2015 White Paper encompasses recommendations that emerged from the extensive discussions held during the workshop, and is aimed at providing the bioanalytical community with key information and practical solutions on topics and issues addressed, in an effort to advance scientific excellence, improve quality and deliver better regulatory compliance. Due to its length, the 2015 edition of this comprehensive White Paper has been divided into three parts. Part 2 covers the recommendations for hybrid LBA/LCMS and regulatory agencies' inputs. Part 1 (small molecule bioanalysis using LCMS) and Part 3 (large molecule bioanalysis using LBA, biomarkers and immunogenicity) will be published in volume 7 of Bioanalysis, issues 22 and 24, respectively. PMID:26627049

  13. Addressing lesbian, gay, bisexual, and transgender issues from the inside: one federal agency's approach.

    PubMed

    Craft, E M; Mulvey, K P

    2001-06-01

    The mission of the Substance Abuse and Mental Health Services Administration (SAMHSA) is to protect and serve underserved and vulnerable populations. Congress established SAMHSA under Public Law 102-321 on October 1, 1992, to strengthen the nation's health care capacity to provide prevention, diagnosis, and treatment services for substance abuse and mental illnesses. SAMHSA works in partnership with states, communities, and private organizations to address the needs of people with substance abuse and mental illnesses as well as the community risk factors that contribute to these illnesses. As part of its efforts to address the unique needs of special populations, SAMHSA has reached out to the lesbian, gay, bisexual, and transgender (LGBT) community. SAMHSA and its centers (Center for Substance Abuse Treatment, Center for Substance Abuse Prevention, and Center for Mental Health Services) have made a concerted effort, through both policy and programs, to develop services responsive to this community. PMID:11392928

  14. Evaluating programs that address ideological issues: ethical and practical considerations for practitioners and evaluators.

    PubMed

    Lieberman, Lisa D; Fagen, Michael C; Neiger, Brad L

    2014-03-01

    There are important practical and ethical considerations for organizations in conducting their own, or commissioning external, evaluations and for both practitioners and evaluators, when assessing programs built on strongly held ideological or philosophical approaches. Assessing whether programs "work" has strong political, financial, and/or moral implications, particularly when expending public dollars, and may challenge objectivity about a particular program or approach. Using a case study of the evaluation of a school-based abstinence-until-marriage program, this article discusses the challenges, lessons learned, and ethical responsibilities regarding decisions about evaluation, specifically associated with ideologically driven programs. Organizations should consider various stakeholders and views associated with their program to help identify potential pitfalls in evaluation. Once identified, the program or agency needs to carefully consider its answers to two key questions: Do they want the answer and are they willing to modify the program? Having decided to evaluate, the choice of evaluator is critical to assuring that ethical principles are maintained and potential skepticism or criticism of findings can be addressed appropriately. The relationship between program and evaluator, including agreements about ownership and eventual publication and/or promotion of data, should be addressed at the outset. Programs and organizations should consider, at the outset, their ethical responsibility when findings are not expected or desired. Ultimately, agencies, organizations, and programs have an ethical responsibility to use their data to provide health promotion programs, whether ideologically founded or not, that appropriately and effectively address the problems they seek to solve. PMID:24532788

  15. Safety and licensing issues that are being addressed by the Power Burst Facility test programs. [PWR; BWR

    SciTech Connect

    McCardell, R.K.; MacDonald, P.E.

    1980-01-01

    This paper presents an overview of the results of the experimental program being conducted in the Power Burst Facility and the relationship of these results to certain safety and licensing issues. The safety issues that were addressed by the Power-Cooling-Mismatch, Reactivity Initiated Accident, and Loss of Coolant Accident tests, which comprised the original test program in the Power Burst Facility, are discussed. The resolution of these safety issues based on the results of the thirty-six tests performed to date, is presented. The future resolution of safety issues identified in the new Power Burst Facility test program which consists of tests which simulate BWR and PWR operational transients, anticipated transients without scram, and severe fuel damage accidents, is described.

  16. Addressing weight-related issues in an elementary school: what do students, parents, and school staff recommend?

    PubMed

    Haines, Jess; Neumark-Sztainer, Dianne; Thiel, Lynnell

    2007-01-01

    This study examined weight-related issues affecting elementary school children to gain insight into how best to address these issues within a school-based intervention. The study population included 21 students, 12 school staff members, and 21 parents from a school that serves an ethnically-diverse population. Data were collected using focus groups and individual interviews and were analyzed using qualitative research methodology. Weight-related teasing and poor body image emerged as prominent issues affecting students. Results suggest that programs aimed at the prevention of weight-related disorders should go beyond issues of nutrition and physical activity and include strategies to reduce weight-related mistreatment and to improve students' body image. PMID:17162638

  17. Policing Matters: Addressing the Controversial Issue of Policing Through Education for Reconciliation

    NASA Astrophysics Data System (ADS)

    Cusack, Mella

    2009-05-01

    Policing is widely held to constitute a contentious issue in classrooms on both sides of the border on the island of Ireland, despite the fact that the ongoing peace process has led to a normalising of cross-border policing relationships. The Education for Reconciliation Project works with teachers and members of the two police services to produce teaching/learning modules on law and policing for use in Citizenship Education classrooms. This paper examines the commonly-held teacher perception of policing as a controversial issue and the reasons why these perceptions exist. It takes into consideration the opinion that it is time for schools to begin work on policing, and investigates the implications for practice.

  18. Addressing non-communicable diseases in disaster risk reduction - an issue of equity.

    PubMed

    Gnanapragasam, Sam; Aitsi-Selmi, Amina; Rashbrook, Elaine; Murray, Virginia

    2016-06-01

    The issues raised by noncommunicable diseases (NCDs) during and after disasters are a challenge to equity within local communities, as well as between countries. Individuals with NCDs are particularly vulnerable in disasters and their aftermath given health systems are disrupted. Although welcome progress has been made in taking NCDs and equity into account in the UN General Assembly ratified agreement, the Sendai Framework for disaster risk reduction 2015-2030, there is need now for a clear plan of implementation. PMID:27001076

  19. Progression in Ethical Reasoning When Addressing Socio-scientific Issues in Biotechnology

    NASA Astrophysics Data System (ADS)

    Berne, Birgitta

    2014-11-01

    This article reports on the outcomes of an intervention in a Swedish school in which the author, a teacher-researcher, sought to develop students' (14-15 years old) ethical reasoning in science through the use of peer discussions about socio-scientific issues. Prior to the student discussions various prompts were used to highlight different aspects of the issues. In addition, students were given time to search for further information themselves. Analysis of students' written arguments, from the beginning of the intervention and afterwards, suggests that many students seem to be moving away from their use of everyday language towards using scientific concepts in their arguments. In addition, they moved from considering cloning and 'designer babies' solely in terms of the present to considering them in terms of the future. Furthermore, the students started to approach the issues in additional ways using not only consequentialism but also the approaches of virtue ethics, and rights and duties. Students' progression in ethical reasoning could be related to the characteristics of the interactions in peer discussions as students who critically and constructively argued with each other's ideas, and challenged each other's claims, made progress in more aspects of ethical reasoning than students merely using cumulative talk. As such, the work provides valuable indications for the importance of introducing peer discussions and debates about SSIs in connection to biotechnology into the teaching of science in schools.

  20. Approaches of the German food industry for addressing the issue of food losses.

    PubMed

    Richter, Beate; Bokelmann, Wolfgang

    2016-02-01

    In the food industry the subject of food losses is of great importance due to economic balance and an efficient application of resources as well as the development of an efficient food chain system. This paper presents the explorative results of a quantitative survey of leading companies of the German food industry to evaluate the relevance and handling of this issue. The investigation reveals that the topic food losses have a high significance in the food industry which will probably increase in future. A sample breakdown by branches indicates that the issue has the highest relevance for companies in the confectionery industry. These companies as well as those in the meat and fish industry want to consider the subject prospectively more powerful in their companies. Across the food industry, there is no communication to consumers of the efforts concerning food losses. And companies in the confectionery industry and in the fruit and vegetable industry rather want to engage more powerful in this topic if consumers' interest increases. But in order to minimize food losses at all stages along the supply chain, communication and collaboration at all stages is essential, especially the communication to consumers. Thus, it has to be verified whether a suitable communication can lead to advantages in competition and become an important issue for companies to differentiate from competitors. PMID:26691601

  1. Instream sand and gravel mining: Environmental issues and regulatory process in the United States

    USGS Publications Warehouse

    Meador, M.R.; Layher, A.O.

    1998-01-01

    Sand and gravel are widely used throughout the U.S. construction industry, but their extraction can significantly affect the physical, chemical, and biological characteristics of mined streams. Fisheries biologists often find themselves involved in the complex environmental and regulatory issues related to instream sand and gravel mining. This paper provides an overview of information presented in a symposium held at the 1997 midyear meeting of the Southern Division of the American Fisheries Society in San Antonio, Texas, to discuss environmental issues and regulatory procedures related to instream mining. Conclusions from the symposium suggest that complex physicochemical and biotic responses to disturbance such as channel incision and alteration of riparian vegetation ultimately determine the effects of instream mining. An understanding of geomorphic processes can provide insight into the effects of mining operations on stream function, and multidisciplinary empirical studies are needed to determine the relative effects of mining versus other natural and human-induced stream alterations. Mining regulations often result in a confusing regulatory process complicated, for example, by the role of the U.S. Army Corps of Engineers, which has undergone numerous changes and remains unclear. Dialogue among scientists, miners, and regulators can provide an important first step toward developing a plan that integrates biology and politics to protect aquatic resources.

  2. The forgotten educational needs of the house staff: training internal medicine residents to address end-of-life issues.

    PubMed

    Kerai, Sara Moore; Wheeler, Margot

    2013-01-01

    An intervention was conducted, aimed at providing residents in internal medicine with communication skills to address end-of-life issues with patients. Residents participated in two 1-hour educational sessions designed to teach a communication protocol, enhance listening skills, and to provide practice in effective communication in a safe, small-group format. An anonymous on-line survey assessed the effectiveness of the intervention. Twenty-five residents completed the intervention. There was a trend toward increased comfort level in addressing end-of-life issues among residents who completed the intervention, versus a comparison group. Residents who completed the intervention reported that using the words "death" and "dying" with patients and families was an important teaching point. PMID:23977790

  3. In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market

    PubMed Central

    Geris, L.; Guyot, Y.; Schrooten, J.; Papantoniou, I.

    2016-01-01

    The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as academic research institutes are in need of tools to advance their understanding and, at the same time, reduce their R&D costs, increase product quality and productivity, and reduce the time to market. An additional difficulty is the regulatory path that needs to be followed, which is challenging in the case of cell-based therapeutic products and should rely on the implementation of quality by design (QbD) principles. In silico modelling is a tool that allows the above-mentioned challenges to be addressed in the field of regenerative medicine. This review discusses such in silico models and focuses more specifically on the bioprocess. Three (clusters of) examples related to this subject are discussed. The first example comes from the pharmaceutical engineering field where QbD principles and their implementation through the use of in silico models are both a regulatory and economic necessity. The second example is related to the production of red blood cells. The described in silico model is mainly used to investigate the manufacturing process of the cell-therapeutic product, and pays special attention to the economic viability of the process. Finally, we describe the set-up of a model capturing essential events in the development of a tissue-engineered combination product in the context of bone tissue engineering. For each of the examples, a short introduction to some economic aspects is given, followed by a description of the in silico tool or tools that have been developed to allow the implementation of QbD principles and optimal design. PMID:27051516

  4. In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market.

    PubMed

    Geris, L; Guyot, Y; Schrooten, J; Papantoniou, I

    2016-04-01

    The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as academic research institutes are in need of tools to advance their understanding and, at the same time, reduce their R&D costs, increase product quality and productivity, and reduce the time to market. An additional difficulty is the regulatory path that needs to be followed, which is challenging in the case of cell-based therapeutic products and should rely on the implementation of quality by design (QbD) principles. In silico modelling is a tool that allows the above-mentioned challenges to be addressed in the field of regenerative medicine. This review discusses such in silico models and focuses more specifically on the bioprocess. Three (clusters of) examples related to this subject are discussed. The first example comes from the pharmaceutical engineering field where QbD principles and their implementation through the use of in silico models are both a regulatory and economic necessity. The second example is related to the production of red blood cells. The described in silico model is mainly used to investigate the manufacturing process of the cell-therapeutic product, and pays special attention to the economic viability of the process. Finally, we describe the set-up of a model capturing essential events in the development of a tissue-engineered combination product in the context of bone tissue engineering. For each of the examples, a short introduction to some economic aspects is given, followed by a description of the in silico tool or tools that have been developed to allow the implementation of QbD principles and optimal design. PMID:27051516

  5. Scalable human ES culture for therapeutic use: propagation, differentiation, genetic modification and regulatory issues.

    PubMed

    Rao, M

    2008-01-01

    Embryonic stem cells unlike most adult stem cell populations can replicate indefinitely while preserving genetic, epigenetic, mitochondrial and functional profiles. ESCs are therefore an excellent candidate cell type for providing a bank of cells for allogenic therapy and for introducing targeted genetic modifications for therapeutic intervention. This ability of prolonged self-renewal of stem cells and the unique advantages that this offers for gene therapy, discovery efforts, cell replacement, personalized medicine and other more direct applications requires the resolution of several important manufacturing, gene targeting and regulatory issues. In this review, we assess some of the advance made in developing scalable culture systems, improvement in vector design and gene insertion technology and the changing regulatory landscape. PMID:18004405

  6. Nutritional issues for older adults: addressing degenerative ageing with long-term studies.

    PubMed

    de Groot, Lisette C P G M

    2016-05-01

    The ageing process is influenced by a variety of factors, including extrinsic, malleable lifestyle variables. The present paper deals with the epidemiological evidence for the role of dietary patterns and key nutritional concerns in relation to survival and ageing-related disorders that present themselves in later life. Healthful dietary patterns appear to be most relevant in old age. Specific nutritional concerns are related to vitamin D, vitamin B12 and protein malnutrition. An important challenge to further expand the knowledge base is currently addressed by the NuAge project, acknowledging the complexity of the ageing process and integrating different dimensions of research into human healthy ageing. In the meantime, reversing poor adherence to existing guidelines for a healthy diet remains a first challenge in public health nutritional practices. PMID:26915284

  7. Religiosity/spirituality of German doctors in private practice and likelihood of addressing R/S issues with patients.

    PubMed

    Voltmer, Edgar; Bussing, Arndt; Koenig, Harold G; Al Zaben, Faten

    2014-12-01

    This study examined the self-assessed religiosity and spirituality (R/S) of a representative sample of German physicians in private practice (n = 414) and how this related to their addressing R/S issues with patients. The majority of physicians (49.3 %)reported a Protestant denomination, with the remainder indicating mainly either Catholic(12.5 %) or none (31.9 %). A significant proportion perceived themselves as either religious(42.8 %) or spiritual (29.0 %). Women were more likely to rate themselves R/S than did men. Women (compared to men) were also somewhat more likely to attend religious services (7.4 vs. 2.1 % at least once a week) and participate in private religious activities(14.9 vs. 13.7 % at least daily), although these differences were not statistically significant.The majority of physicians (67.2 %) never/seldom addressed R/S issues with a typical patient. Physicians with higher self-perceived R/S and more frequent public and private religious activity were much more likely to address R/S issues with patients. Implications for patient care and future research are discussed. PMID:24077926

  8. Developing and Using Benchmarks for Eddy Current Simulation Codes Validation to Address Industrial Issues

    NASA Astrophysics Data System (ADS)

    Mayos, M.; Buvat, F.; Costan, V.; Moreau, O.; Gilles-Pascaud, C.; Reboud, C.; Foucher, F.

    2011-06-01

    To achieve performance demonstration, which is a legal requirement for the qualification of NDE processes applied on French nuclear power plants, the use of modeling tools is a valuable support, provided that the employed models have been previously validated. To achieve this, in particular for eddy current modeling, a validation methodology based on the use of specific benchmarks close to the actual industrial issue has to be defined. Nonetheless, considering the high variability in code origin and complexity, the feedback from experience on actual cases has shown that it was critical to define simpler generic and public benchmarks in order to perform a preliminary selection. A specific Working Group has been launched in the frame of COFREND, the French Association for NDE, resulting in the definition of several benchmark problems. This action is now ready for mutualization with similar international approaches.

  9. Introduction: what are the issues in addressing the allergenic potential of genetically modified foods?

    PubMed Central

    Metcalfe, Dean D

    2003-01-01

    There is growing concern among the general public and the scientific community regarding the potential toxicity of genetically modified organisms (GMOs). The use of biotechnology to enhance pest resistance or nutritional value has raised a number of fundamental questions including the consequences of insertion of reporter genes, the spread of resistance genes to surrounding plants, and the use of suicide genes to prohibit reuse of seed from engineered plants. Of particular interest is the ability of proteins from GMOs to elicit potentially harmful immunologic responses, including allergic hypersensitivity. The lack of information of the potential toxicity of these products suggests a need to identify the critical issues and research needs regarding these materials and to develop testing strategies to examine the allergenicity of these compounds. PMID:12826482

  10. Introduction: what are the issues in addressing the allergenic potential of genetically modified foods?

    PubMed

    Metcalfe, Dean D

    2003-06-01

    There is growing concern among the general public and the scientific community regarding the potential toxicity of genetically modified organisms (GMOs). The use of biotechnology to enhance pest resistance or nutritional value has raised a number of fundamental questions including the consequences of insertion of reporter genes, the spread of resistance genes to surrounding plants, and the use of suicide genes to prohibit reuse of seed from engineered plants. Of particular interest is the ability of proteins from GMOs to elicit potentially harmful immunologic responses, including allergic hypersensitivity. The lack of information of the potential toxicity of these products suggests a need to identify the critical issues and research needs regarding these materials and to develop testing strategies to examine the allergenicity of these compounds. PMID:12826482

  11. Regulatory policy issues and the Clean Air Act: An interim report on the state implementation workshops

    SciTech Connect

    Rose, K.; Burns, R.E.

    1992-08-01

    The National Regulatory Research Institute (NRRI), with funding from the U.S. Environmental Protection Agency (EPA) and U.S. Department of Energy (DOE), conducted two workshops on state public utility commission implementation of the Clean Air Act Amendments of 1990 (CAAA). The first workshop was held in Charlotte, North Carolina for southern and eastern states in April 1992 and the second was held in St. Louis, Missouri for Midwestern states in May. The workshops had four objectives: (1) discuss key issues and concerns on CAAA implementation, (2) encourage a discussion among states on issues of common interest, (3) attempt to reach consensus, where possible, on some key issues, and (4) provide the workshop participants with information and materials to assist in developing rules, orders, and procedures in their state. Of primary interest from the federal perspective was for workshop participants to return to their states with additional background and understanding of how state commission actions may affect implementation of the CAAA and enable them to provide guidance to their jurisdictional utilities. It was hoped this would reduce some of the uncertainty utilities face and assist in the development of an efficient allowance market. The basic format of the workshops was that invited speakers made presentations on specific issues. {open_quotes}Primary participants{close_quotes} from each state and other workshop attendees then discussed the issues raised by the speakers and other related concerns. The primary participants were state commissioners, commission staff, representatives from state consumer advocate organizations, EPA, DOE, and the Federal Energy Regulatory Commission (FERC). Other attendees were utility representatives, consultants, and other interested parties. All participants were given a workbook with excerpts from an NRRI report on CAAA implementation and papers or outlines from speakers.

  12. Safety and regulatory issues regarding stem cell therapies: one clinic's perspective.

    PubMed

    Centeno, Christopher J; Bashir, Jamil

    2015-04-01

    Stem cells therapies have been in preclinical development for the past 2 decades. A rapidly evolving regulatory landscape has restrained many of these technologies from advancing from the bench to the bedside. Although the large-scale clinical safety of stem cell therapies remains to be fully tested, the total number of patients who have safely received these therapies is large and growing. Prima facie evidence would dictate that certain types of cell therapy are likely safer than others. Understanding the current regulation regarding stem cells involves a discussion of their safety profile, as the 2 issues are closely intertwined. PMID:25864659

  13. Biomedical research, a tool to address the health issues that affect African populations

    PubMed Central

    2013-01-01

    Traditionally, biomedical research endeavors in low to middle resources countries have focused on communicable diseases. However, data collected over the past 20 years by the World Health Organization (WHO) show a significant increase in the number of people suffering from non-communicable diseases (e.g. heart disease, diabetes, cancer and pulmonary diseases). Within the coming years, WHO predicts significant decreases in communicable diseases while non-communicable diseases are expected to double in low and middle income countries in sub-Saharan Africa. The predicted increase in the non-communicable diseases population could be economically burdensome for the basic healthcare infrastructure of countries that lack resources to address this emerging disease burden. Biomedical research could stimulate development of healthcare and biomedical infrastructure. If this development is sustainable, it provides an opportunity to alleviate the burden of both communicable and non-communicable diseases through diagnosis, prevention and treatment. In this paper, we discuss how research using biomedical technology, especially genomics, has produced data that enhances the understanding and treatment of both communicable and non-communicable diseases in sub-Saharan Africa. We further discuss how scientific development can provide opportunities to pursue research areas responsive to the African populations. We limit our discussion to biomedical research in the areas of genomics due to its substantial impact on the scientific community in recent years however, we also recognize that targeted investments in other scientific disciplines could also foster further development in African countries. PMID:24143865

  14. Integrated resource planning for local gas distribution companies: A critical review of regulatory policy issues

    SciTech Connect

    Harunuzzaman, M.; Islam, M.

    1994-08-01

    According to the report, public utility commissions (PUCs) are increasingly adopting, or considering the adoption of integrated resource planning (IRP) for local gas distribution companies (LDCs). The Energy Policy Act of 1992 (EPAct) requires PUCs to consider IRP for gas LDCs. This study has two major objectives: (1) to help PUCs develop appropriate regulatory approaches with regard to IRP for gas LDCs; and (2) to help PUCs respond to the EPAct directive. The study finds that it is appropriate for PUCs to pursue energy efficiency within the traditional regulatory framework of minimizing private costs of energy production and delivery; and PUCs should play a limited role in addressing environmental externalities. The study also finds that in promoting energy efficiency, PUCs should pursue policies that are incentive-based, procompetitive, and sensitive to rate impacts. The study evaluates a number of traditional and nontraditional ratemaking mechanisms on the basis of cost minimization, energy efficiency, competitiveness, and other criteria. The mechanisms evaluated include direct recovery of DSM expenses, lost revenue adjustments for DSM options, revenue decoupling mechanisms, sharing of DSM cost savings, performance-based rate of return for DSM, provision of DSM as a separate service, deregulation of DSM service, price caps, and deregulation of the noncore gas market. The study concludes with general recommendations for regulatory approaches and ratemaking mechanisms that PUCs may wish to consider in advancing IRP objectives.

  15. Evaluation of Geese Theatre's Re-Connect program: addressing resettlement issues in prison.

    PubMed

    Harkins, Leigh; Pritchard, Cecilia; Haskayne, Donna; Watson, Andy; Beech, Anthony R

    2011-06-01

    This study examined the impact of Geese Theatre's Re-Connect program on a sample of offenders who attended it. This program used theatre performance, experiential exercises, skills practice role-plays, and metaphors such as the masks to invite a group of offenders to consider and explore issues connected with their release and reconnecting with a life outside prison. Pre- and postprogram psychometric tests, behavior ratings, and interviews were completed to assess the effectiveness of the program. Significant changes were observed from pre- to posttreatment in terms of self-efficacy, motivation to change, and improved confidence in skills (i.e., social and friendship, occupational, family and intimacy, dealing with authority, alternatives to aggression or offending, and self-management and self-control skills). Improved behavior and engagement within the program was observed over the 3 days of the program. Interviews also revealed the positive impact the program had on the participants. This provides evidence supporting the short-term effectiveness of the Re-Connect program. PMID:20472705

  16. Addressing oral health disparities, inequity in access and workforce issues in a developing country.

    PubMed

    Singh, Abhinav; Purohit, Bharathi M

    2013-10-01

    The health sector challenges in India like those in other low and middle income countries are formidable. India has almost one-third of the world's dental schools. However, provisions of oral health-care services are few in rural parts of India where the majority of the Indian population resides. Disparities exist between the oral health status in urban and rural areas. The present unequal system of mainly private practice directed towards a minority of the population and based on reparative services needs to be modified. National oral health policy needs to be implemented as a priority, with an emphasis on strengthening dental care services under public health facilities. A fast-changing demographic profile and its implications needs to be considered while planning for the future oral health-care workforce. Current oral health status in developing countries, including India, is a result of government public health policies, not lack of dentists. The aim of the article is to discuss pertinent issues relating to oral health disparities, equity in health-care access, dental workforce planning and quality concerns pertaining to the present-day dental education and practices in India, which have implications for other developing countries. PMID:24074015

  17. Methods to address poultry robustness and welfare issues through breeding and associated ethical considerations

    PubMed Central

    Muir, William M.; Cheng, Heng-Wei; Croney, Candace

    2014-01-01

    As consumers and society in general become more aware of ethical and moral dilemmas associated with intensive rearing systems, pressure is put on the animal and poultry industries to adopt alternative forms of housing. This presents challenges especially regarding managing competitive social interactions between animals. However, selective breeding programs are rapidly advancing, enhanced by both genomics and new quantitative genetic theory that offer potential solutions by improving adaptation of the bird to existing and proposed production environments. The outcomes of adaptation could lead to improvement of animal welfare by increasing fitness of the animal for the given environments, which might lead to increased contentment and decreased distress of birds in those systems. Genomic selection, based on dense genetic markers, will allow for more rapid improvement of traits that are expensive or difficult to measure, or have a low heritability, such as pecking, cannibalism, robustness, mortality, leg score, bone strength, disease resistance, and thus has the potential to address many poultry welfare concerns. Recently selection programs to include social effects, known as associative or indirect genetic effects (IGEs), have received much attention. Group, kin, multi-level, and multi-trait selection including IGEs have all been shown to be highly effective in reducing mortality while increasing productivity of poultry layers and reduce or eliminate the need for beak trimming. Multi-level selection was shown to increases robustness as indicated by the greater ability of birds to cope with stressors. Kin selection has been shown to be easy to implement and improve both productivity and animal well-being. Management practices and rearing conditions employed for domestic animal production will continue to change based on ethical and scientific results. However, the animal breeding tools necessary to provide an animal that is best adapted to these changing conditions

  18. Using Next Generation Science Standards (NGSS) Practices to Address Scientific Misunderstandings Around Complex Environmental Issues

    NASA Astrophysics Data System (ADS)

    Turrin, M.; Kenna, T. C.

    2014-12-01

    The new NGSS provide an important opportunity for scientists to develop curriculum that links the practice of science to research-based data in order to improve understanding in areas of science that are both complex and confusing. Our curriculum focuses in particular on the fate and transport of anthropogenic radionuclides. Radioactivity, both naturally occurring and anthropogenic, is highly debated and largely misunderstood, and for large sections of the population is a source of scientific misunderstanding. Developed as part of the international GEOTRACES project which focuses on identifying ocean processes and quantifying fluxes that control the distributions of selected trace elements and isotopes in the ocean, and on establishing the sensitivity of these distributions to changing environmental conditions, the curriculum topic fits nicely into the applied focus of NGSS with both environmental and topical relevance. Our curriculum design focuses on small group discussion driven by questions, yet unlike more traditional curriculum pieces these are not questions posed to the students, rather they are questions posed by the students to facilitate their deeper understanding. Our curriculum design challenges the traditional question/answer memorization approach to instruction as we strive to develop an educational approach that supports the practice of science as well as the NGSS Cross Cutting Concepts and the Science & Engineering Practices. Our goal is for students to develop a methodology they can employ when faced with a complex scientific issue. Through background readings and team discussions they identify what type of information is important for them to know and where to find a reliable source for that information. Framing their discovery around key questions such as "What type of radioactive decay are we dealing with?", "What is the potential half-life of the isotope?", and "What are the pathways of transport of radioactivity?" allows students to evaluate a

  19. End of Life and Life After Death - Issues to be Addressed.

    PubMed

    Sridhar, Poojar; Renuka, Pramod Kallur Parameshwar; Bonanthaya, Ravikiran

    2012-09-01

    Being an Oncologist, I have seen many patients suffering from cancer. It pains a lot looking at them fighting the battle of life, though knowing that they would lose miserably and surrender meekly as majority of the patients report to the hospital at an advanced stage of disease and only palliative care may be the option. There is an urgent need to create - Cancer Awareness in the villages and also about the end of life care in all terminally ill patients. 20 patients in the terminal phase were questioned regarding end of life care. The common questions they asked are, why has God punished me like this? Why me on earth? Should I die so early? Why should I leave my near and dear ones and go far away, from the point of no return? Do I ever see them again? With deep sorrow and sigh, they suffer till the last breath, having the feeling of insecurity as what would happen to their dear ones. In the terminal phase, the patients wishes must be respected and their needs must be fulfilled. The health care professionals should plan an appropriate care for each patient. Most of them feel that the best place to be in end of life is the home. Research has shown that Hospice care may improve the quality of life of a patient who is dying and of the patient's family. Communication about end of life care and decision making during the final moments of a person's life are very important. The patients suffering are mainly due to the physical, psychological, social and spiritual issues. Death of a terminally ill patient should never be a sudden loss. All healthcare professionals, Social workers and Non-Governmental Organisations must install the life after death of the person, who has struggled for every breath and assure that he/she shall rest in peace and shall smile seeing their near and dear ones living with dignity and pride in the society. Ultimately, the patient must have dignity in dying. PMID:23440306

  20. Secondary Education Systemic Issues: Addressing Possible Contributors to a Leak in the Science Education Pipeline and Potential Solutions

    NASA Astrophysics Data System (ADS)

    Young, Hollie

    2005-06-01

    To maintain the legacy of cutting edge scientific innovation in the United States our country must address the many pressing issues facing science education today. One of the most important issues relating to science education is the under-representation of African Americans and Hispanics in the science, technology, and engineering workforce. Foreshadowing such under-representation in the workforce are the disproportionately low rates of African American and Hispanic students attaining college degrees in science and related fields. Evidence suggests disparate systemic factors in secondary science education are contributing to disproportionately low numbers of African American and Hispanic students in the science education pipeline. The present paper embarks on a critical analysis of the issue by elucidating some of the systemic factors within secondary education that contribute to the leak in the science education pipeline. In addition, this review offers a synthesis and explication of some of the policies and programs being implemented to address disparate systemic factors in secondary schools. Finally, recommendations are offered regarding potential mechanisms by which disparities may be alleviated.

  1. 2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 2 - hybrid LBA/LCMS, ELN & regulatory agencies' input).

    PubMed

    Dufield, Dawn; Neubert, Hendrik; Garofolo, Fabio; Kirkovsky, Leo; Stevenson, Lauren; Dumont, Isabelle; Kaur, Surinder; Xu, Keyang; Alley, Stephen C; Szapacs, Matthew; Arnold, Mark; Bansal, Surendra; Haidar, Sam; Welink, Jan; Le Blaye, Olivier; Wakelin-Smith, Jason; Whale, Emma; Ishii-Watabe, Akiko; Bustard, Mark; Katori, Noriko; Amaravadi, Lakshmi; Aubry, Anne-Françoise; Beaver, Chris; Bergeron, Annik; Cai, Xiao-Yan; Cojocaru, Laura; DeSilva, Binodh; Duggan, Jeff; Fluhler, Eric; Gorovits, Boris; Gupta, Swati; Hayes, Roger; Ho, Stacy; Ingelse, Benno; King, Lindsay; Lévesque, Ann; Lowes, Steve; Ma, Mark; Musuku, Adrien; Myler, Heather; Olah, Timothy; Patel, Shefali; Rose, Mark; Schultz, Gary; Smeraglia, John; Swanson, Steven; Torri, Albert; Vazvaei, Faye; Wilson, Amanda; Woolf, Eric; Xue, Li; Yang, Tong-Yuan

    2014-01-01

    The 2014 8th Workshop on Recent Issues in Bioanalysis (8th WRIB), a 5-day full immersion in the evolving field of bioanalysis, took place in Universal City, California, USA. Close to 500 professionals from pharmaceutical and biopharmaceutical companies, contract research organizations and regulatory agencies worldwide convened to share, review, discuss and agree on approaches to address current issues of interest in bioanalysis. The topics covered included both small and large molecules, and involved LCMS, hybrid LBA/LCMS, LBA approaches and immunogenicity. From the prolific discussions held during the workshop, specific recommendations are presented in this 2014 White Paper. As with the previous years' editions, this paper acts as a practical tool to help the bioanalytical community continue advances in scientific excellence, improved quality and better regulatory compliance. Due to its length, the 2014 edition of this comprehensive White Paper has been divided into three parts for editorial reasons. This publication (Part 2) covers the recommendations for Hybrid LBA/LCMS, Electronic Laboratory Notebook and Regulatory Agencies' Input. Part 1 (Small molecules bioanalysis using LCMS) was published in the Bioanalysis issue 6(22) and Part 3 (Large molecules bioanalysis using LBA and Immunogenicity) will be published in the Bioanalysis issue 6(24). PMID:25529890

  2. The triad of success in personalised medicine: pharmacogenomics, biotechnology and regulatory issues from a Central European perspective.

    PubMed

    Mesko, Bertalan; Zahuczky, Gabor; Nagy, Laszlo

    2012-09-15

    The population of the world has recently passed the 7 billion milestone and as the cost of human genome sequencing is rapidly declining, sequence data of billions of people should be accessible much sooner than anyone would have predicted 10 years ago. This will form the basis of personalised medicine. However it is still not clear, even in principle, whether these data, combined with data of the expression of one's genome in various cells and tissues relevant to different diseases, could be used effectively in clinical medicine and healthcare, or in predicting responses to different therapies. Therefore this is an important issue which needs to be addressed before more resources are wasted on less than informative studies and surveys simply because technologies exist. As a typical example, we have selected and summarise here key studies from the biomedical literature that focus on gene expression profiling of the response to biologic therapies in peripheral blood and biopsy samples in autoimmune diseases such as rheumatoid arthritis, spondylarthropathy, inflammatory bowel diseases and psoriasis. We also present the state of the biotechnology market from a European perspective, discuss how spin-offs leverage the power of genomic technologies and describe how they might contribute to personalised medicine. As ethical, legal and social issues are essential in the area of genomics, we analysed these aspects and present here the European situation with a special focus on Hungary. We propose that the synergy of these three issues: pharmacogenomics, biotechnology and regulatory issues should be considered a triad necessary to succeed in personalised medicine. PMID:22414700

  3. Langley's DEVELOP Team Applies NASA's Earth Observations to Address Environmental Issues Across the Country and Around the Globe

    NASA Technical Reports Server (NTRS)

    Childs, Lauren M.; Miller, Joseph E.

    2011-01-01

    The DEVELOP National Program was established over a decade ago to provide students with experience in the practical application of NASA Earth science research results. As part of NASA's Applied Sciences Program, DEVELOP focuses on bridging the gap between NASA technology and the public through projects that innovatively use NASA Earth science resources to address environmental issues. Cultivating a diverse and dynamic group of students and young professionals, the program conducts applied science research projects during three terms each year (spring, summer, and fall) that focus on topics ranging from water resource management to natural disasters.

  4. Do Supplemental Remedial Reading Programs Address the Motivational Issues of Struggling Readers? An Analysis of Five Popular Programs

    PubMed Central

    Quirk, Matthew P.; Schwanenflugel, Paula J.

    2009-01-01

    Five popular, but distinctly different, remedial reading programs were reviewed regarding the potential to motivate children to read. It is argued that current remedial reading program designs and research on program effectiveness ignore the impact that motivation has on struggling readers. In addition, we develop a theory of reading motivation specific to struggling readers that highlights motivational constructs we feel are important to the improvement of reading skill for this population of students. The three aspects of reading motivation most relevant to the instruction of remedial readers include: (a) improving reading self-efficacy; (b) making internal and controllable outcome attributions for successes and failures associated with reading; and (c) establishing personally relevant value in becoming a better reader. We conclude that, while most programs address some motivational issues and other issues not at all, most programs could make minor modifications that would greatly enhance their motivational impact. PMID:20076771

  5. Hardware-in-the-loop environment facility to address pilot-vehicle-interface issues of a fighter aircraft

    NASA Astrophysics Data System (ADS)

    Pandurangareddy, Meenige

    2002-07-01

    The evolution of Pilot-Vehicle-Interface (PVI) of a fighter aircraft is a complex task. The PVI design involves both static and dynamic issues. Static issues involve the study of reach of controls and switches, ejection path clearance, readability of indicators and display symbols, etc. Dynamic issues involve the study of the effect of aircraft motion on display symbols, pilot emergency handling, situation awareness, weapon aiming, etc. This paper describes a method of addressing the above issues by building a facility with cockpit, which is ergonomically similar to the fighter cockpit. The cockpit is also fitted with actual displays, controls and switches. The cockpit is interfaced with various simulation models of aircraft and outside-window-image generators. The architecture of the facility is designed to represent the latencies of the aircraft and facilitates replacement of simulation models with actual units. A parameter injection facility could be used to induce faults in a comprehensive manner. Pilots could use the facility right from familiarising themselves with procedures to start the engine, take-off, navigate, aim the weapons, handling of emergencies and landing. This approach is being followed and further being enhanced on Cockpit-Environment-Facility (CEF) at Aeronautical Development Agency (ADA), Bangalore, India.

  6. Comprehensive Lifecycle Planning and Management System For Addressing Water Issues Associated With Shale Gas Development In New York, Pennsylvania, And West Virginia

    SciTech Connect

    Arthur, J. Daniel

    2012-07-01

    The objective of this project is to develop a modeling system to allow operators and regulators to plan all aspects of water management activities associated with shale gas development in the target project area of New York, Pennsylvania, and West Virginia (target area ), including water supply, transport, storage, use, recycling, and disposal and which can be used for planning, managing, forecasting, permit tracking, and compliance monitoring. The proposed project is a breakthrough approach to represent the entire shale gas water lifecycle in one comprehensive system with the capability to analyze impacts and options for operational efficiency and regulatory tracking and compliance, and to plan for future water use and disposition. It will address all of the major water-related issues of concern associated with shale gas development in the target area, including water withdrawal, transport, storage, use, treatment, recycling, and disposal. It will analyze the costs, water use, and wastes associated with the available options, and incorporate constraints presented by permit requirements, agreements, local and state regulations, equipment and material availability, etc. By using the system to examine the water lifecycle from withdrawals through disposal, users will be able to perform scenario analysis to answer "what if" questions for various situations. The system will include regulatory requirements of the appropriate state and regional agencies and facilitate reporting and permit applications and tracking. These features will allow operators to plan for more cost effective resource production. Regulators will be able to analyze impacts of development over an entire area. Regulators can then make informed decisions about the protections and practices that should be required as development proceeds. This modeling system will have myriad benefits for industry, government, and the public. For industry, it will allow planning all water management operations for a

  7. Regulatory Safety Issues in the Structural Design Criteria of ASME Section III Subsection NH and for Very High Temperatures for VHTR & GEN IV

    SciTech Connect

    William J. O’Donnell; Donald S. Griffin

    2007-05-07

    The objective of this task is to identify issues relevant to ASME Section III, Subsection NH [1], and related Code Cases that must be resolved for licensing purposes for VHTGRs (Very High Temperature Gas Reactor concepts such as those of PBMR, Areva, and GA); and to identify the material models, design criteria, and analysis methods that need to be added to the ASME Code to cover the unresolved safety issues. Subsection NH was originally developed to provide structural design criteria and limits for elevated-temperature design of Liquid Metal Fast Breeder Reactor (LMFBR) systems and some gas-cooled systems. The U.S. Nuclear Regulatory Commission (NRC) and its Advisory Committee for Reactor Safeguards (ACRS) reviewed the design limits and procedures in the process of reviewing the Clinch River Breeder Reactor (CRBR) for a construction permit in the late 1970s and early 1980s, and identified issues that needed resolution. In the years since then, the NRC and various contractors have evaluated the applicability of the ASME Code and Code Cases to high-temperature reactor designs such as the VHTGRs, and identified issues that need to be resolved to provide a regulatory basis for licensing. This Report describes: (1) NRC and ACRS safety concerns raised during the licensing process of CRBR , (2) how some of these issues are addressed by the current Subsection NH of the ASME Code; and (3) the material models, design criteria, and analysis methods that need to be added to the ASME Code and Code Cases to cover unresolved regulatory issues for very high temperature service.

  8. Vitrification of underground storage tanks: Technology development, regulatory issues, and cost analysis

    SciTech Connect

    Tixier, J.S.; Corathers, L.A.; Anderson, L.D.

    1992-03-01

    In situ vitrification (ISV), developed by the Pacific Northwest Laboratory (PNL) for the US Department of Energy (DOE), is a thermal treatment process for the remediation of hazardous, radioactive, or mixed waste sites. The process has been broadly patented both domestically and abroad. Since the inception of ISV in 1980, developmental activities have been focused on applications to contaminated soils, and more recently the potential for application to buried wastes and underground structures (tanks). Research performed to date on the more advanced ISV applications (i.e., application to buried wastes and underground tanks) shows that significant technical and economic potential exists for using ISV to treat buried wastes and underground structures containing radionuclides and/or hazardous constituents. Present ISV applications are directed to the treatment of contaminated soils; the likelihood of using ISV to treat underground tanks depends on the resolution of significant technical and institutional issues related to this advanced application. This paper describes the ISV process and summarizes the technical progress of underground tank vitrification (UTV), discusses pertinent regulatory issues facing the use of UTV, and presents the potential cost of UTV relative to other remedial action alternatives.

  9. A Cost-Efficient LDPC Decoder for DVB-S2 with the Solution to Address Conflict Issue

    NASA Astrophysics Data System (ADS)

    Ying, Yan; Bao, Dan; Yu, Zhiyi; Zeng, Xiaoyang; Chen, Yun

    In this paper, a cost-efficient LDPC decoder for DVB-S2 is presented. Based on the Normalized Min-Sum algorithm and the turbo-decoding message-passing (TDMP) algorithm, a dual line-scan scheduling is proposed to enable hardware reusing. Furthermore, we present the solution to the address conflict issue caused by the characteristic of the parity-check matrix defined by DVB-S2 LDPC codes. Based on SMIC 0.13µm standard CMOS process, the LDPC decoder has an area of 12.51mm2. The required operating frequency to meet the throughput requirement of 135Mbps with maximum iteration number of 30 is 105MHz. Compared with the latest published DVB-S2 LDPC decoder, the proposed decoder reduces area cost by 34%.

  10. Patient and healthcare perspectives on the importance and efficacy of addressing spiritual issues within an interdisciplinary bone marrow transplant clinic: a qualitative study

    PubMed Central

    Sinclair, Shane; McConnell, Shelagh; Raffin Bouchal, Shelley; Ager, Naree; Booker, Reanne; Enns, Bert; Fung, Tak

    2015-01-01

    Objectives The purpose of this study was to use a qualitative approach to better understand the importance and efficacy of addressing spiritual issues within an interdisciplinary bone marrow transplant clinic from the perspectives of patients and healthcare providers. Setting Participants were recruited from the bone marrow transplant clinic of a large urban outpatient cancer care centre in western Canada. Participants: Focus groups were conducted with patients (n=7) and healthcare providers (n=9) to explore the importance of addressing spiritual issues across the treatment trajectory and to identify factors associated with effectively addressing these needs. Results Data were analysed using the qualitative approach of latent content analysis. Addressing spiritual issues was understood by patients and healthcare providers, as a core, yet under addressed, component of comprehensive care. Both sets of participants felt that addressing basic spiritual issues was the responsibility of all members of the interdisciplinary team, while recognising the need for specialised and embedded support from a spiritual care professional. While healthcare providers felt that the impact of the illness and treatment had a negative effect on patients’ spiritual well-being, patients felt the opposite. Skills, challenges, key time points and clinical indicators associated with addressing spiritual issues were identified. Conclusions Despite a number of conceptual and clinical challenges associated with addressing spiritual issues patients and their healthcare providers emphasised the importance of an integrated approach whereby basic spiritual issues are addressed by members of the interdisciplinary team and by an embedded spiritual care professional, who in addition also provides specialised support. The identification of clinical issues associated with addressing spiritual needs provides healthcare providers with clinical guidance on how to better integrate this aspect of care into

  11. Practical guidelines addressing ethical issues pertaining to the curation of human locus-specific variation databases (LSDBs)

    PubMed Central

    Povey, Sue; Al Aqeel, Aida I; Cambon-Thomsen, Anne; Dalgleish, Raymond; den Dunnen, Johan T; Firth, Helen V; Greenblatt, Marc S; Barash, Carol Isaacson; Parker, Michael; Patrinos, George P; Savige, Judith; Sobrido, Maria-Jesus; Winship, Ingrid; Cotton, Richard GH

    2010-01-01

    More than 1,000 Web-based locus-specific variation databases (LSDBs) are listed on the Website of the Human Genetic Variation Society (HGVS). These individual efforts, which often relate phenotype to genotype, are a valuable source of information for clinicians, patients, and their families, as well as for basic research. The initiators of the Human Variome Project recently recognized that having access to some of the immense resources of unpublished information already present in diagnostic laboratories would provide critical data to help manage genetic disorders. However, there are significant ethical issues involved in sharing these data worldwide. An international working group presents second-generation guidelines addressing ethical issues relating to the curation of human LSDBs that provide information via a Web-based interface. It is intended that these should help current and future curators and may also inform the future decisions of ethics committees and legislators. These guidelines have been reviewed by the Ethics Committee of the Human Genome Organization (HUGO). Hum Mutat 31:–6, 2010. © 2010 Wiley-Liss, Inc. PMID:20683926

  12. Addressing the Federal-State-Local Interface Issues During a Catastrophic Event Such as an Anthrax Attack

    SciTech Connect

    Stein, Steven L.; Lesperance, Ann M.; Upton, Jaki F.

    2010-02-01

    On October 9, 2008, federal, state and local policy makers, emergency managers, and medical and public health officials convened in Seattle, Washington, for a workshop on Addressing the Federal-State-Local Interface Issues During a Catastrophic Event Such as an Anthrax Attack. The day-long symposium was aimed at generating a dialogue about recovery and restoration through a discussion of the associated challenges that impact entire communities, including people, infrastructure, and critical systems. The Principal Federal Official (PFO) provided an overview of the role of the PFO in a catastrophic event. A high-level summary of an anthrax scenario was presented. The remainder of the day was focused on interactive discussions among federal, state and local emergency management experts in the areas of: • Decision-making, prioritization, and command and control • Public health/medical services • Community resiliency and continuity of government. Key topics and issues that resulted from discussions included: • Local representation in the Joint Field Office (JFO) • JFO transition to the Long-Term Recovery Office • Process for prioritization of needs • Process for regional coordination • Prioritization - process and federal/military intervention • Allocation of limited resources • Re-entry decision and consistency • Importance of maintaining a healthy hospital system • Need for a process to establish a consensus on when it is safe to re-enter. This needs to be across all jurisdictions including the military. • Insurance coverage for both private businesses and individuals • Interaction between the government and industry. The symposium was sponsored by the Interagency Biological Restoration Demonstration, a collaborative regional program jointly funded by the U.S. Department of Homeland Security and the U.S. Department of Defense. To aid the program’s efforts and inform the development of blueprint for recovery from a biological incident

  13. Current issues and actions

    SciTech Connect

    Black, D.G.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the progress that has been made toward achieving full regulatory compliance at the Hanford Site. Ongoing compliance self-assessments, implementation of the Tri-Party Agreement, and public meetings continue to identify environmental compliance issues. These issues are discussed openly with the regulatory agencies and with the public to ensure that all environmental compliance issues are addressed.

  14. Interactive efforts to address DSM and IRP issues: Findings from the first year of a two-year study

    SciTech Connect

    Schweitzer, M.; English, M.; Altman, J.; Yourstone, E.

    1993-04-01

    This report presents findings from the first year of a two-year study of interactive efforts involving utilities and non-utility parties (NUPS) working together to prepare plans, develop Demand-Side Management (DSM) programs, or otherwise promote integrated planning and the use of cost-effective DSM measures. Of the ten cases covered in the current study, seven involved the collaborative approach to NUP involvement, which generally is marked by intensive utility-NUP interactions designed to reach consensus on a broad range of important issues; in collaboratives, outside consultants often are provided to enhance the technical capabilities of the NUPS. Another of the cases in this study involved a ``cooperative arrangement,`` whereby a utility and a NLT worked together in a focused short-term effort to develop a single DSM program. The intense interaction involved in this approach makes it very similar to a collaborative, except that both the scope and the duration of the effort were much more limited than in a normal collaborative. The ninth case concerned a task force run by state regulatory staff that was charged with the limited job of studying various cost-effectiveness tests available for assessing prospective DSM measures. All of these approaches (collaborative, cooperative arrangement, and task force) are types of interactive effort, as that term is used in this report. The final case concerned NUPs` attempts to encourage greater utility use of DSM in Florida but, to date, no interactive effort has been initiated there. Three main features of interactive efforts are described in this report: (1) the participants involved; (2) the context in which the efforts took place; and (3) key characteristics of the interactive process. This report also examines the outcomes achieved by the interactive efforts. These outcomes can be divided into two general categories: Product-related and participant-related.

  15. Interactive efforts to address DSM and IRP issues: Findings from the first year of a two-year study

    SciTech Connect

    Schweitzer, M. ); English, M.; Altman, J. . Energy, Environment and Resources Center); Yourstone, E. )

    1993-04-01

    This report presents findings from the first year of a two-year study of interactive efforts involving utilities and non-utility parties (NUPS) working together to prepare plans, develop Demand-Side Management (DSM) programs, or otherwise promote integrated planning and the use of cost-effective DSM measures. Of the ten cases covered in the current study, seven involved the collaborative approach to NUP involvement, which generally is marked by intensive utility-NUP interactions designed to reach consensus on a broad range of important issues; in collaboratives, outside consultants often are provided to enhance the technical capabilities of the NUPS. Another of the cases in this study involved a cooperative arrangement,'' whereby a utility and a NLT worked together in a focused short-term effort to develop a single DSM program. The intense interaction involved in this approach makes it very similar to a collaborative, except that both the scope and the duration of the effort were much more limited than in a normal collaborative. The ninth case concerned a task force run by state regulatory staff that was charged with the limited job of studying various cost-effectiveness tests available for assessing prospective DSM measures. All of these approaches (collaborative, cooperative arrangement, and task force) are types of interactive effort, as that term is used in this report. The final case concerned NUPs' attempts to encourage greater utility use of DSM in Florida but, to date, no interactive effort has been initiated there. Three main features of interactive efforts are described in this report: (1) the participants involved; (2) the context in which the efforts took place; and (3) key characteristics of the interactive process. This report also examines the outcomes achieved by the interactive efforts. These outcomes can be divided into two general categories: Product-related and participant-related.

  16. What Is the Purpose of the Theses Addressing the Issue of Program Evaluation in Turkey? (The Case of Curriculum and Instruction: 1997-2015)

    ERIC Educational Resources Information Center

    Alkin-Sahin, Senar; Tunca, Nihal

    2016-01-01

    In the current study, the aim is to investigate the theses addressing the issue of program evaluation in the field of Curriculum and Instruction (C&I) in 1997-2015. The study employed the survey model. The universe of the study consists of totally 87 theses addressing the issue of program evaluation in the field of C&I in 1997-2015. As the…

  17. Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective

    PubMed Central

    Ono, Masahiro; Tanaka, Reiko J

    2016-01-01

    Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression. This perspective is based on the key evidence that CD25+ Tregs emigrate to neonatal spleen a few days later than other T cells and that thymectomy of 3-day-old mice depletes Tregs only, causing autoimmune diseases. Although widely believed, the evidence has never been reproduced as originally reported, and some studies indicate that Tregs exist in neonates. Thus we examine the consequences of the controversial evidence, revisit the fundamental issues of Tregs and thereby reveal the overlooked relationship of T-cell activation and Foxp3-mediated control of the T-cell system. Here we provide a new model of Tregs and Foxp3, a feedback control perspective, which views Tregs as a component of the system that controls T-cell activation, rather than as a distinct genetically programmed lineage. This perspective provides new insights into the roles of self-reactivity, T cell–antigen-presenting cell interaction and T-cell activation in Foxp3-mediated immune regulation. PMID:26215792

  18. Brand names of Portuguese medication: understanding the importance of their linguistic structure and regulatory issues.

    PubMed

    Pires, Carla; Vigário, Marina; Cavaco, Afonso

    2015-08-01

    Among other regulatory requirements, medicine brands should be composed of single names without abbreviations to prevent errors in prescription of medication. The purposes of the study were to investigate the compliance of a sam ple of Portuguese medicine brand names with Portuguese pharmaceutical regulations. This includes identifying their basic linguistic characteristics and comparing these features and their frequency of occurrence with benchmark values of the colloquial or informal language. A sample of 474 brand names was selected. Names were analyzed using manual (visual analyses) and computer methods (FreP - Frequency Patterns of Phonological Objects in Portuguese and MS word). A significant number of names (61.3%) failed to comply with the Portuguese phonologic system (related to the sound of words) and/or the spelling system (related to the written form of words) contained more than one word, comprised a high proportion of infrequent syllable types or stress patterns and included abbreviations. The results suggest that some of the brand names of Portuguese medication should be reevaluated, and that regulation on this issue should be enforced and updated, taking into consideration specific linguistic and spelling codes. PMID:26221822

  19. Fort Collins Science Center Ecosystem Dynamics branch--interdisciplinary research for addressing complex natural resource issues across landscapes and time

    USGS Publications Warehouse

    Bowen, Zachary H.; Melcher, Cynthia P.; Wilson, Juliette T.

    2013-01-01

    The Ecosystem Dynamics Branch of the Fort Collins Science Center offers an interdisciplinary team of talented and creative scientists with expertise in biology, botany, ecology, geology, biogeochemistry, physical sciences, geographic information systems, and remote-sensing, for tackling complex questions about natural resources. As demand for natural resources increases, the issues facing natural resource managers, planners, policy makers, industry, and private landowners are increasing in spatial and temporal scope, often involving entire regions, multiple jurisdictions, and long timeframes. Needs for addressing these issues include (1) a better understanding of biotic and abiotic ecosystem components and their complex interactions; (2) the ability to easily monitor, assess, and visualize the spatially complex movements of animals, plants, water, and elements across highly variable landscapes; and (3) the techniques for accurately predicting both immediate and long-term responses of system components to natural and human-caused change. The overall objectives of our research are to provide the knowledge, tools, and techniques needed by the U.S. Department of the Interior, state agencies, and other stakeholders in their endeavors to meet the demand for natural resources while conserving biodiversity and ecosystem services. Ecosystem Dynamics scientists use field and laboratory research, data assimilation, and ecological modeling to understand ecosystem patterns, trends, and mechanistic processes. This information is used to predict the outcomes of changes imposed on species, habitats, landscapes, and climate across spatiotemporal scales. The products we develop include conceptual models to illustrate system structure and processes; regional baseline and integrated assessments; predictive spatial and mathematical models; literature syntheses; and frameworks or protocols for improved ecosystem monitoring, adaptive management, and program evaluation. The descriptions

  20. Addressing Cultural Issues in an Organizational Context. Edited Conference Proceedings of the Teachers College Winter Roundtable (New York, New York, 1992).

    ERIC Educational Resources Information Center

    Johnson, Samuel D., Jr., Ed.; Carter, Robert T., Ed.

    Papers from this year's conference reflect the Roundtable's theme of addressing cultural issues in an organizational context. Topics cover a wide range of institutional and organizational issues in corporate, educational, and treatment settings. Papers include: (1) "The New Corporate Language for Race Relations" (keynote) (Clayton P. Alderfer);…

  1. Addressing Social Issues in the Classroom and Beyond: The Pedagogical Efforts of Pioneers in the Field. Research in Curriculum and Instruction

    ERIC Educational Resources Information Center

    Totten, Samuel, Ed.; Pedersen, Jon, Ed.

    2007-01-01

    Addressing Social Issues in the Classroom and Beyond: The Pedagogical Efforts of Pioneers in the Field is comprised of essays that delineate the genesis and evolution of the thought and work of pioneers in the field of social issues and education. The authors (many of whom, themselves, are noted professors of education and who have done…

  2. MEETING IN TUCSON: MODEL EVALUATION SCIENCE TO MEET TODAY'S QUALITY ASSURANCE REQUIREMENTS FOR REGULATORY USE: ADDRESSING UNCERTAINTY, SENSITIVITY, AND PARAMETERIZATION

    EPA Science Inventory

    The EPA/ORD National Exposure Research Lab's (NERL) UA/SA/PE research program addresses both tactical and strategic needs in direct support of ORD's client base. The design represents an integrated approach in achieving the highest levels of quality assurance in environmental dec...

  3. MODEL EVALUATION SCIENCE TO MEET TODAY'S QUALITY ASSURANCE REQUIREMENTS FOR REGULATORY USE: ADDRESSING UNCERTAINTY, SENSITIVITY, AND PARAMETERIZATION

    EPA Science Inventory

    The EPA/ORD National Exposure Research Lab's (NERL) UA/SA/PE research program addresses both tactical and strategic needs in direct support of ORD's client base. The design represents an integrated approach in achieving the highest levels of quality assurance in environmental de...

  4. Overview of US AID-World Bank-NASA Collaboration to Address Water Management Issues in the MENA Region

    NASA Technical Reports Server (NTRS)

    Habib, Shahid

    2012-01-01

    The World Bank, USAID and NASA have recently established a joint project to study multiple issues pertaining to water related applications in the Middle East North Africa (MENA) region. The main concentration of the project is on utilization of remote sensing data and hydrological models to address crop irrigation and mapping, flood mapping and forecasting, evapotranspiration and drought problems prevalent in this large geographic area. Additional emphases are placed on understanding the climate impact on these areas as well. Per IPCC 2007 report, by the end of this century MENA region is projected to experience an increase of 3 C to 5 C rise in mean temperatures and a 20% decline in precipitation. This poses a serious problem for this geographic zone especially when majority of the hydrological consumption is for the agriculture sector and the remaining amount is for domestic consumption. The remote sensing data from space is one of the best ways to study such complex issues and further feed into the decision support systems. NASA's fleet of Earth Observing satellites offer a great vantage point from space to look at the globe and provide vital signs necessary to maintain healthy and sustainable ecosystem. These observations generate multiple products such as soil moisture, global precipitation, aerosols, cloud cover, normalized difference vegetation index, land cover/use, ocean altimetry, ocean salinity, sea surface winds, sea surface temperature, ozone and atmospheric gases, ice and snow measurements, and many more. All of the data products, models and research results are distributed-via the Internet freely through out the world. This project will utilize several NASA models such as global Land Data Assimilation System (LDAS) to generate hydrological states and fluxes in near real time. These LDAS products will then be further compared with other NASA satellite observations (MODIS, VIIRS, TRMM, etc.) and other discrete models to compare and optimize

  5. Innovative patient-centered skills training addressing challenging issues in cancer communications: Using patient's stories that teach.

    PubMed

    Bishop, Thomas W; Gorniewicz, James; Floyd, Michael; Tudiver, Fred; Odom, Amy; Zoppi, Kathy

    2016-05-01

    This workshop demonstrated the utility of a patient-centered web-based/digital Breaking Bad News communication training module designed to educate learners of various levels and disciplines. This training module is designed for independent, self-directed learning as well as group instruction. These interactive educational interventions are based upon video-recorded patient stories. Curriculum development was the result of an interdisciplinary, collaborative effort involving faculty from the East Tennessee State University (ETSU) Graduate Storytelling Program and the departments of Family and Internal Medicine at the James H. Quillen College of Medicine. The specific goals of the BBN training module are to assist learners in: (1) understanding a five-step patient-centered model that is based upon needs, preferences, and expectations of patients with cancer and (2) individualizing communication that is consistent with patient preferences in discussing emotions, informational detail, prognosis and timeline, and whether or not to discuss end-of-life issues. The pedagogical approach to the training module is to cycle through Emotional Engagement, Data, Modeled Practices, Adaptation Opportunities, and Feedback. The communication skills addressed are rooted in concepts found within the Reaching Common Ground communication training. A randomized control study investigating the effectiveness of the Breaking Bad News module found that medical students as well as resident physicians improved their communication skills as measured by an Objective Structured Clinical Examination. Four other similarly designed modules were also created: Living Through Treatment, Transitions: From Curable to Treatable/From Treatable to End-of-Life, Spirituality, and Family. PMID:27497456

  6. Overview of regulatory/policy/economic issues related to carbon dioxide.

    PubMed

    Leaf, Dennis; Verolme, Hans J H; Hunt, William F

    2003-06-01

    This is an overview of Session 2c dealing with the regulatory, policy and economic issues related to carbon dioxide and its impact on global climate change. The information is taken from the two papers presented in this session (the U.S. Perspective by Dennis Leaf and the European Perspective by Hans J.H. Verolme) and from the panel discussion that took place at the end of the session. The overview focuses primarily on the policy responses of both the United States (US) and the United Kingdom (UK) to changes in global atmospheric pollution. To a lesser extent, the progress of policy responses to these changes is discussed. The United Nations Framework Convention on Climate Change (UNFCCC) has been signed and ratified by over 180 countries. The UNFCCC contained no binding targets or timetables for emissions reductions. The Kyoto Protocol [United Nations. Kyoto Protocol to the United Nations Framework Convention on Climate Change. UNEP.IUC/99/10. Chatlelaine, Switzerland: United Nations Environment Programme's Information Unit for Conventions, for the Climate Change Secretariat, 1997] to the UNFCCC did contain targets and timetables for reductions of greenhouse gases on the part of developed countries. The US has signed but not ratified the Kyoto Protocol. The US has experienced some movement to reduce greenhouse gas emissions on the part of various levels of government, as well as the private sector. The UK's commitment to reducing green house gases is laid down in the UK Climate Change Programme 2000. The UK is a member of the European Union (EU). In this context, an example of EU-wide progress, the voluntary agreement with car manufacturers to reduce CO(2) emissions in new vehicles, will be discussed. In addition, there will be some discussion on the UK CO(2) trading scheme that created the first market in the world in April 2001. Overall, the policy process is constantly informed by scientific research. In the case of climate change, much of this work is carried

  7. What Educators in Catholic Schools Might Expect when Addressing Gay and Lesbian Issues: A Study of Needs and Barriers

    ERIC Educational Resources Information Center

    Maher, Michael J.; Sever, Linda M.

    2007-01-01

    Previous research indicated that Catholic high schools in the United States were not addressing the topic of homosexuality in any significant and systematic way prior to the mid-1990s, though practitioners in Catholic high schools have begun to address the topic in recent years. This study, in sampling seven Catholic schools in the greater Chicago…

  8. Regulatory approaches to obesity prevention: A systematic overview of current laws addressing diet-related risk factors in the European Union and the United States.

    PubMed

    Sisnowski, Jana; Handsley, Elizabeth; Street, Jackie M

    2015-06-01

    High prevalence of overweight and obesity remains a significant international public health problem. Law has been identified as a tool for obesity prevention and selected high-profile measures have been reported. However, the nature and extent of enacted legislation internationally are unclear. This research provides an overview of regulatory approaches enacted in the United States, the European Union, and EU Member States since 2004. To this end, relevant databases of primary and secondary legislation were systematically searched to identify and explore laws addressing dietary risk factors for obesity. Across jurisdictions, current regulatory approaches to obesity prevention are limited in reach and scope. Target groups are rarely the general population, but instead sub-populations in government-supported settings. Consumer information provision is preferred over taxation and marketing restrictions other than the regulation of health and nutrition claims. In the EU in particular, product reformulation with industry consent has also emerged as a popular small-scale measure. While consistent and widespread use of law is lacking, governments have employed a range of regulatory measures in the name of obesity prevention, indicating that there is, in principle, political will. Results from this study may serve as a starting point for future research and policy development. PMID:25963556

  9. 76 FR 58846 - Final Interim Staff Guidance: Review of Evaluation To Address Gas Accumulation Issues in Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... guidance documents. Disposition: On November 12, 2009 (74 FR 58323), the NRC staff issued proposed DC/COL....5.2, ``Containment Spray System'' of NUREG-0800, ``Standard Review Plan for the Review of...

  10. Top 10 Ways To Improve Public Schools. Innovative Solutions To Help Address the Issues and Challenges Facing Most Public School Districts.

    ERIC Educational Resources Information Center

    Texas State Comptroller of Public Accounts, Austin.

    This report offers the top 10 challenges identified by public schools and the ways that the Texas School Performance Review (TSPR) suggests that these issues be addressed. The TSPR ensures that scarce education resources are spent in the classroom. For a TSPR review, the TSPR team is invited in for months of detailed study, during which it asks…

  11. 76 FR 40282 - Proposed Generic Communications; Draft NRC Regulatory Issue Summary 2011-XX; NRC Regulation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ..., ``Requirements for Expanded Definition of Byproduct Material'' (72 FR 55864; October 1, 2007), (hereinafter... Material'' (72 FR 55864; October 1, 2007). The RIS describes regulatory approaches to implement NRC's.... See NARM Rule (72 FR 55864; October 1, 2007). Additionally, NRC established a definition for the...

  12. Structural Analysis of the Global Multimedia Scenario: Technological, Market, Environmental, and Regulatory Issues.

    ERIC Educational Resources Information Center

    Nicolo, Enrico; Sapio, Bartolomeo

    1996-01-01

    Presents a strategic evaluation of the global multimedia scenario, considering both stand-alone workstations and distributed multimedia in the worldwide interactive network, including educational databases on the Internet. Discusses 50 technological, market, environmental, and regulatory factors and estimates their impacts on each other using WISE…

  13. 75 FR 27028 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... COMMISSION COMMODITY FUTURES TRADING COMMISSION Joint CFTC-SEC Advisory Committee on Emerging Regulatory... and CFTC Commissioners, respectively, intend to establish the Joint CFTC-SEC Advisory Committee on... both Agencies. Respondents are encouraged to use the title ``Joint CFTC-SEC Advisory Committee''...

  14. Regulatory and institutional issues impending cleanup at US Department of Energy sites: Perspectives gained from an office of environmental restoration workshop

    SciTech Connect

    Fallon, W E; Gephart, J M; Gephart, R E; Quinn, R D; Stevenson, L A

    1991-05-01

    The US Department of Energy's (DOE) nuclear weapons and energy operations are conducted across a nation-wide industrial complex engaged in a variety of manufacturing, processing, testing, and research and development activities. The overall mission of DOE Office of Environmental Restoration and Waste Management (EM) is to protect workers, the public, and the environment from waste materials generated by past, current, and future DOE activities and to bring the DOE complex into compliance with all applicable laws, regulations, and agreements related to health, safety, and the environment. EM addresses this broad mandate through related and interdependent programs that include corrective actions, waste operations, environmental restoration, and technology development. The EM Office of Environmental Restoration (EM-40) recognizes the importance of implementing a complex-wide process to identify and resolve those issues that may impede progress towards site cleanup. As a first step in this process, FM-40 sponsored an exercise to identify and characterize major regulatory and institutional issues and to formulate integrated action steps towards their resolution. This report is the first product of that exercise. It is intended that the exercise described here will mark the beginning of an ongoing process of issue identification, tracking, and resolution that will benefit cleanup activities across the DOE complex.

  15. Inclusion in Urban Educational Environments: Addressing Issues of Diversity, Equity, and Social Justice. Issues in the Research, Theory, Policy, and Practice of Urban Education

    ERIC Educational Resources Information Center

    Armstrong, Denise E.; McMahon, Brenda J.

    2006-01-01

    This book is motivated by the authors' experiences in working with students and their families in urban communities. They are particularly concerned about the urgent imperative to address the endemic educational and societal challenges that pervade the lives of urban students, particularly those who live in poverty, are of minority and immigrant…

  16. A Task-Based Needs Analysis for Australian Aboriginal Students: Going beyond the Target Situation to Address Cultural Issues

    ERIC Educational Resources Information Center

    Oliver, Rhonda; Grote, Ellen; Rochecouste, Judith; Exell, Michael

    2013-01-01

    While needs analyses underpin the design of second language analytic syllabi, the methodologies undertaken are rarely examined. This paper explores the value of multiple data sources and collection methods for developing a needs analysis model to enable vocational education and training teachers to address the needs of Australian Aboriginal…

  17. Race and Racism: The Efforts of Counseling Psychology to Understand and Address the Issues Associated With These Terms

    ERIC Educational Resources Information Center

    Casas, J. Manuel

    2005-01-01

    This paper focuses on race and racism with the underlying hope and expectation that in the near future the terms race and racism will be more accurately understood and, when necessary, more appropriately and selectively addressed by the field of counseling psychology. With respect to the term racism, it is hoped that the efforts of counseling…

  18. Insights into the Interactions between Educational Messages: Looking across Multiple Organizations Addressing Water Issues in Maricopa County, Arizona

    ERIC Educational Resources Information Center

    Cutts, Bethany; Saltz, Charlene; Elser, Monica

    2008-01-01

    The public receives environmental information from a variety of sources. Evaluation of a single program or one organization's effort is incomplete. Through surveys and interviews, we evaluate the cumulative impact of outreach by 20 water-related organizations in Maricopa County, Arizona. Household water conservation is a topic addressed by 18…

  19. Addressing Three Common Issues in Research on Youth Activities: An Integrative Approach for Operationalizing and Analyzing Involvement

    ERIC Educational Resources Information Center

    Busseri, Michael A.; Rose-Krasnor, Linda

    2010-01-01

    Youth activity involvement has been operationalized and analyzed using a wide range of approaches. Researchers face the challenges of distinguishing between the effects of involvement versus noninvolvement and intensity of involvement in a particular activity, accounting simultaneously for cumulative effects of involvement, and addressing multiple…

  20. The American Competitiveness Initiative: Addressing the STEM Teacher Shortage and Improving Student Academic Readiness. BHEF Issue Brief

    ERIC Educational Resources Information Center

    Business-Higher Education Forum (NJ1), 2006

    2006-01-01

    America's leaders are increasingly concerned about U.S. competitiveness in a rapidly globalizing world. In response, during the 2006 State of the Union Address, President Bush introduced the American Competitiveness Initiative (ACI) to promote policy that bolsters student achievement in the areas of science, technology, engineering, and…

  1. Nuclear Regulatory Commission activities to prepare for reviewing license applications and issuing licenses

    SciTech Connect

    Uleck, R.B.; DeFino, C.V.

    1991-12-31

    The Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA) assigned States the responsibility to provide for disposal of commercial low-level radioactive waste (LLRW) by 1993. The LLRWPAA also required the US Nuclear Regulatory Commission (NRC) to establish procedures and develop the technical review capability to process license applications for new LLRW disposal facilities. Under the LLRWPAA, NRC is required, to the extent practicable, to complete its review of an LLRW disposal facility license application within 15 months of its submittal by a State. This provision of the LLRWPAA helps ensure that NRC, in addition to protecting public health and safety and the environment, facilitates States` achievement of LLRWPAA milestones for new facility development. A timely NRC review is needed for States to accomplish their objective of having new disposal facilities in operation on the dates prescribed in the LLRWPAA. To help assure NRC and States` compliance with the provisions of the LLRWPAA, NRC has developed a licensing review strategy that includes: (1) the further development of regulatory guidance, (2) enhancement of licensing review capability, and (3) prelicensing regulatory consultation with potential applicants.

  2. Women Reaching Women: Change in Action--Using Action Learning to Help Address Seemingly Intractable and Large Scale Social Issues

    ERIC Educational Resources Information Center

    Langley, Dawn; Watts, Richard

    2010-01-01

    In 2008, 28 women from the Women's Institute volunteered to join us in a project exploring the issue of world poverty and gender inequality, specifically highlighting the disproportionate effects of climate change on women. Collectively we were asking a big question about how we as individuals, based in England, make a difference on a global…

  3. A Discussion of Some Issues Pertaining to the Structure of Postsecondary Education in Ontario and Some Suggestions for Addressing Them

    ERIC Educational Resources Information Center

    Skolnik, Michael L.

    2005-01-01

    This article discusses some of the principal policy issues regarding the structure of postsecondary education that are facing Ontario. The discussion is divided into four sections, the first three of which concern particular aspects of the structure of postsecondary education. The first deals with questions pertaining to the appropriate structure…

  4. Beyond Boston: Applying Theory to Understand and Address Sustainability Issues in Focused Deterrence Initiatives for Violence Reduction

    ERIC Educational Resources Information Center

    Tillyer, Marie Skubak; Engel, Robin S.; Lovins, Brian

    2012-01-01

    Focused deterrence initiatives, including the most famous, Boston's Operation Ceasefire, have been associated with significant reductions in violence in several U.S. cities. Despite early successes, some cities have experienced long-term sustainability issues. Recent work in Cincinnati, Ohio, has focused on institutionalizing focused deterrence in…

  5. Assessment of the National Wind Coordinating Collaborative: Addressing Environmental and Siting Issues Associated with Wind Energy Development

    SciTech Connect

    Van Cleve, Frances B.; States, Jennifer C.

    2010-11-09

    The National Wind Coordinating Collaborative (NWCC) is a consensus-based stakeholder group comprised of representatives from the utility, wind industry, environmental, consumer, regulatory, power marketer, agricultural, tribal, economic development, and state and federal government sectors. The purpose of the NWCC is to support the development of an environmentally, economically, and politically sustainable commercial market for wind power (NWCC 2010). The NWCC has been funded by the U.S. Department of Energy (DOE) since its inception in 1994. In order to evaluate the impact of the work of the NWCC and how this work aligns with DOE’s strategic priorities, DOE tasked Pacific Northwest National Laboratory (PNNL) to conduct a series of informal interviews with a small sample of those involved with NWCC.

  6. Regulatory issues in vitrification research: A case study of circuit board reclamation

    SciTech Connect

    Bickford, D.F.; Compton, K.L.; Bennert, D.M.

    1993-05-01

    Vitrification has shown great potential as a method of remediation, as it incorporates aspects of all of the fundamental treatment techniques of destruction, extraction, and immobilization. A wide variety of waste streams can be treated to levels acceptable for disposal in municipal solid waste landfills. However, it is important that an individual considering vitrification as a treatment method understands the regulatory mechanism whereby a vitrified waste may be disposed of in a Subtitle D (i.e. non-hazardous) land disposal facility. This presentation is designed to orient the individual to the current RCRA requirements for land disposal of vitrified waste residues.

  7. Regulatory issues in vitrification research: A case study of circuit board reclamation

    SciTech Connect

    Bickford, D.F. ); Compton, K.L.; Bennert, D.M. . Dept. of Environmental Systems Engineering)

    1993-01-01

    Vitrification has shown great potential as a method of remediation, as it incorporates aspects of all of the fundamental treatment techniques of destruction, extraction, and immobilization. A wide variety of waste streams can be treated to levels acceptable for disposal in municipal solid waste landfills. However, it is important that an individual considering vitrification as a treatment method understands the regulatory mechanism whereby a vitrified waste may be disposed of in a Subtitle D (i.e. non-hazardous) land disposal facility. This presentation is designed to orient the individual to the current RCRA requirements for land disposal of vitrified waste residues.

  8. A survey of physical dosimetry to date and in the near future: Part 1. Review of standards and regulatory issues.

    PubMed

    Cassata, James R

    2002-02-01

    This article summarizes the status of the relevant standards and current regulatory issues for use of physical dosimetry devices for the occupational worker in the United States. Included is a summary of relevant standards from the International Organization for Standardization (ISO), the International Electrotechnical Commission (IEC), the American National Standards Institute (ANSI), the United States Nuclear Regulatory Commission NUREG-Series, the National Voluntary Laboratory Accreditation Program (NVLAP), the Department of Energy Laboratory Accreditation Program (DOELAP), and the U.S. Military Specifications and Standards (MIL-STD). Proposed changes to ANSI N13.11-1993, "American National Standard for Dosimetry-Personnel Dosimetry Performance Criteria for Testing," are listed. The strategic changes that the United States Nuclear Regulatory Commission (NRC) is making in rulemaking activities related to dosimetry and standards are given. The status of Measurement Program Description (MPD) C.18, "Implementation of Electronic Dosimetry for Primary Dosimetry," from the Council on Ionizing Radiation Measurements and Standards (CIRMS) is given. PMID:11873507

  9. Is It More Important to Address the Issue of Patient Mobility or to Guarantee Universal Health Coverage in Europe?

    PubMed Central

    Legido-Quigley, Helena

    2016-01-01

    This paper discusses whether European institutions should devote so much attention and funding to cross-border healthcare or they should instead prioritise guaranteeing universal health coverage (UHC), “addressing inequalities” and tackling the effects of austerity measures. The paper argues through providing the evidence in both areas of research, that the priority at European level from a public health and social justice perspective should be to guarantee UHC for all the population living in Europe and prioritise protective action for those who are most in need. PMID:26673649

  10. Measuring Cognitive and Metacognitive Regulatory Processes during Hypermedia Learning: Issues and Challenges

    ERIC Educational Resources Information Center

    Azevedo, Roger; Moos, Daniel C.; Johnson, Amy M.; Chauncey, Amber D.

    2010-01-01

    Self-regulated learning (SRL) with hypermedia environments involves a complex cycle of temporally unfolding cognitive and metacognitive processes that impact students' learning. We present several methodological issues related to treating SRL as an event and strengths and challenges of using online trace methodologies to detect, trace, model, and…

  11. Some statistical and regulatory issues in the evaluation of genetic and genomic tests.

    PubMed

    Campbell, Gregory

    2004-08-01

    The genomics revolution is reverberating throughout the worlds of pharmaceutical drugs, genetic testing and statistical science. This revolution, which uses single nucleotide polymorphisms (SNPs) and gene expression technology, including cDNA and oligonucleotide microarrays, for a range of tests from home-brews to high-complexity lab kits, can allow the selection or exclusion of patients for therapy (responders or poor metabolizers). The wide variety of US regulatory mechanisms for these tests is discussed. Clinical studies to evaluate the performance of such tests need to follow statistical principles for sound diagnostic test design. Statistical methodology to evaluate such studies can be wide ranging, including receiver operating characteristic (ROC) methodology, logistic regression, discriminant analysis, multiple comparison procedures resampling, Bayesian hierarchical modeling, recursive partitioning, as well as exploratory techniques such as data mining. Recent examples of approved genetic tests are discussed. PMID:15468751

  12. Legal and regulatory issues in hospital laboratory outreach and partnering arrangements.

    PubMed

    Goodman, Bruce G

    2003-01-01

    An independent laboratory's joint venture with a chain of five nonprofit hospitals unraveled in 1999. Despite substantial management control over the joint venture and 3 years spent investing in and managing a massive consolidation project, the laboratory operator was ousted by the hospital group in favor of a national laboratory competitor. In the process, it lost the $6 million commercial laboratory business it brought to the joint venture. The laboratory operator sued the hospital group for destroying its business. Were the hospital's actions legal? Could the laboratory operator have protected itself better? Although by no means the only causes of this disaster, regulatory restrictions and uncertain contract terms contributed to the problems experienced by the laboratory operator. PMID:12813953

  13. Transforming public utility commissions in the new regulatory environment: Some issues and ideas for managing change

    SciTech Connect

    Wirick, D.W.; Davis, V.W.; Burns, R.E.; Jones, D.N.

    1996-07-01

    In the face of sweeping changes in utility markets and regulatory practices, public utility commissions are being forced to change in fundamental ways--to substantially transform themselves rather than to make only incremental changes in their operations. Managing this process of radical change is complicated by the fact that for the foreseeable future some portions of utility markets (e.g., water utilities) will function much as they have before. Some envision commissions in the future that are more externally focussed, that rely more on dispute resolution than adjudicatory proceedings, that concentrate on identifying and understanding competitive markets, that are more automated, and that are more likely to question old assumptions and definitions. This report identifies the considerations commissions might apply for identifying what mix of skills or fields of experise should compromise the technical staff. Factors are also identified which point towards a sectoral arrangement of staff and those factors which point toward a functional approach.

  14. International and domestic regulator issues facing the Canadian MSAT system

    NASA Technical Reports Server (NTRS)

    Bahman, Azarbar; Langlois, Jacques R.; Frank, Christopher J.

    1988-01-01

    International and domestic regulatory issues which affect the implementation of a mobile satellite system (MSAT) over North America are addressed. WARC-MOB-87, MSAT frequency co-ordination, frequency sharing and key Canadian domestic issues are discussed.

  15. Addressing System Integration Issues Required for the Developmente of Distributed Wind-Hydrogen Energy Systems: Final Report

    SciTech Connect

    Mann, M.D; Salehfar, H.; Harrison, K.W.; Dale, N.; Biaku, C.; Peters, A.J.; Hernandez-Pacheco: E.

    2008-04-01

    Wind generated electricity is a variable resource. Hydrogen can be generated as an energy storage media, but is costly. Advancements in power electronics and system integration are needed to make a viable system. Therefore, the long-term goal of the efforts at the University of North Dakota is to merge wind energy, hydrogen production, and fuel cells to bring emission-free and reliable power to commercial viability. The primary goals include 1) expand system models as a tool to investigate integration and control issues, 2) examine long-term effects of wind-electrolysis performance from a systematic perspective, and 3) collaborate with NREL and industrial partners to design, integrate, and quantify system improvements by implementing a single power electronics package to interface wild AC to PEM stack DC requirements. This report summarizes the accomplishments made during this project.

  16. Fostering youth leadership to address workplace and community environmental health issues: a university-school-community partnership.

    PubMed

    Delp, Linda; Brown, Marianne; Domenzain, Alejandra

    2005-07-01

    Many communities of color are disproportionately exposed to workplace and community environmental hazards. This article presents the results of a pilot project designed by a university-school-community partnership to develop youth leadership to confront these exposures. Using a popular empowerment education approach, students applied peer education, research, and organizing skills learned in the classroom to community-based internships in a service-learning model. Evaluation results from pretests and posttests, focus groups, and in-depth interviews demonstrated that students shared what they learned about young workers' rights and environmental justice with family and friends. They developed a critical analysis of environmental inequities, created a citywide youth coalition that advocates around legal, educational, and environmental issues affecting youth, and implemented campaigns to enforce child labor laws and to prevent school construction on contaminated land. This multifaceted model can serve as an important foundation to develop youth leaders to influence environmental policies in a variety of communities. PMID:16020622

  17. Addressing Work-Related Issues in Medical Rehabilitation: Revision of an Online Information Tool for Healthcare Professionals

    PubMed Central

    Wolf, Hans-Dieter; Gerlich, Christian; Vogel, Heiner; Neuderth, Silke

    2016-01-01

    Background. Medical rehabilitation increasingly considers occupational issues as determinants of health and work ability. Information on work-related rehabilitation concepts should therefore be made available to healthcare professionals. Objective. To revise a website providing healthcare professionals in medical rehabilitation facilities with information on work-related concepts in terms of updating existing information and including new topics, based on recommendations from implementation research. Method. The modification process included a questionnaire survey of medical rehabilitation centers (n = 28); two workshops with experts from rehabilitation centers, health payers, and research institutions (n = 14); the selection of new topics and revision of existing text modules based on expert consensus; and an update of good practice descriptions of work-related measures. Results. Health payers' requirements, workplace descriptions, and practical implementation aids were added as new topics. The database of good practice examples was extended to 63 descriptions. Information on introductory concepts was rewritten and supplemented by current data. Diagnostic tools were updated by including additional assessments. Conclusions. Recommendations from implementation research such as assessing user needs and including expert knowledge may serve as a useful starting point for the dissemination of information on work-related medical rehabilitation into practice. Web-based information tools such as the website presented here can be quickly adapted to current evidence and changes in medicolegal regulations. PMID:27610246

  18. The causality between smoking and lung cancer among groups and individuals: addressing issues in tobacco litigation in South Korea

    PubMed Central

    Khang, Young-Ho

    2015-01-01

    This article discusses issues on the causality between smoking and lung cancer, which have been raised during the tobacco litigation in South Korea. It should be recognized that the explanatory ability of risk factor(s) for inter-individual variations in disease occurrence is different from the causal contribution of the risk factor(s) to disease occurrence. The affected subjects of the tobacco litigation in South Korea are lung cancer patients with a history of cigarette smoking. Thus, the attributable fraction of the exposed rather than the population attributable fraction should be used in the tobacco litigation regarding the causal contribution of smoking to lung cancer. Scientific evidence for the causal relationship between smoking and lung cancer is based on studies of individuals and groups, studies in animals and humans, studies that are observational or experimental, studies in laboratories and communities, and studies in both underdeveloped and developed countries. The scientific evidence collected is applicable to both groups and individuals. The probability of causation, which is calculated based on the attributable fraction for the association between smoking and lung cancer, could be utilized as evidence to prove causality in individuals. PMID:26137845

  19. Addressing Work-Related Issues in Medical Rehabilitation: Revision of an Online Information Tool for Healthcare Professionals.

    PubMed

    Lukasczik, Matthias; Wolf, Hans-Dieter; Gerlich, Christian; Küffner, Roland; Vogel, Heiner; Neuderth, Silke

    2016-01-01

    Background. Medical rehabilitation increasingly considers occupational issues as determinants of health and work ability. Information on work-related rehabilitation concepts should therefore be made available to healthcare professionals. Objective. To revise a website providing healthcare professionals in medical rehabilitation facilities with information on work-related concepts in terms of updating existing information and including new topics, based on recommendations from implementation research. Method. The modification process included a questionnaire survey of medical rehabilitation centers (n = 28); two workshops with experts from rehabilitation centers, health payers, and research institutions (n = 14); the selection of new topics and revision of existing text modules based on expert consensus; and an update of good practice descriptions of work-related measures. Results. Health payers' requirements, workplace descriptions, and practical implementation aids were added as new topics. The database of good practice examples was extended to 63 descriptions. Information on introductory concepts was rewritten and supplemented by current data. Diagnostic tools were updated by including additional assessments. Conclusions. Recommendations from implementation research such as assessing user needs and including expert knowledge may serve as a useful starting point for the dissemination of information on work-related medical rehabilitation into practice. Web-based information tools such as the website presented here can be quickly adapted to current evidence and changes in medicolegal regulations. PMID:27610246

  20. Addressing the Amorphous Content Issue in Quantitative Phase Analysis: The Certification of NIST Standard Reference Material 676a

    SciTech Connect

    J Cline; R Von Dreele; R Winburn; P Stephens; J Filliben

    2011-12-31

    A non-diffracting surface layer exists at any boundary of a crystal and can comprise a mass fraction of several percent in a finely divided solid. This has led to the long-standing issue of amorphous content in standards for quantitative phase analysis (QPA). NIST standard reference material (SRM) 676a is a corundum ({alpha}-Al{sub 2}O{sub 3}) powder, certified with respect to phase purity for use as an internal standard in powder diffraction QPA. The amorphous content of SRM 676a is determined by comparing diffraction data from mixtures with samples of silicon powders that were engineered to vary their specific surface area. Under the (supported) assumption that the thickness of an amorphous surface layer on Si was invariant, this provided a method to control the crystalline/amorphous ratio of the silicon components of 50/50 weight mixtures of SRM 676a with silicon. Powder diffraction experiments utilizing neutron time-of-flight and 25 keV and 67 keV X-ray energies quantified the crystalline phase fractions from a series of specimens. Results from Rietveld analyses, which included a model for extinction effects in the silicon, of these data were extrapolated to the limit of zero amorphous content of the Si powder. The certified phase purity of SRM 676a is 99.02% {+-} 1.11% (95% confidence interval). This novel certification method permits quantification of amorphous content for any sample of interest, by spiking with SRM 676a.

  1. Successful Drug Development Despite Adverse Preclinical Findings Part 1: Processes to Address Issues and Most Important Findings

    PubMed Central

    Kuroda, Junji; Plassmann, Stephanie; Prentice, David E.

    2010-01-01

    Unexpected adverse preclinical findings (APFs) are not infrequently encountered during drug development. Such APFs can be functional disturbances such as QT prolongation, morphological toxicity or carcinogenicity. The latter is of particular concern in conjunction with equivocal genotoxicity results. The toxicologic pathologist plays an important role in recognizing these effects, in helping to characterize them, to evaluate their risk for man, and in proposing measures to mitigate the risk particularly in early clinical trials. A careful scientific evaluation is crucial while termination of the development of a potentially useful drug must be avoided. This first part of the review discusses processes to address unexpected APFs and provides an overview over typical APFs in particular classes of drugs. If the mode of action (MoA) by which a drug candidate produces an APF is known, this supports evaluation of its relevance for humans. Tailor-made mechanistic studies, when needed, must be planned carefully to test one or several hypotheses regarding the potential MoA and to provide further data for risk evaluation. Safety considerations are based on exposure at no-observed-adverse-effect levels (NOAEL) of the most sensitive and relevant animal species and guide dose escalation in clinical trials. The availability of early markers of toxicity for monitoring of humans adds further safety to clinical studies. Risk evaluation is concluded by a weight of evidence analysis (WoE) with an array of parameters including drug use, medical need and alternatives on the market. In the second part of this review relevant examples of APFs will be discussed in more detail. PMID:22272031

  2. Regulatory compliance issues related to the White Oak Creek Embayment time-critical removal action

    SciTech Connect

    Leslie, M. ); Kimmel, B.L. )

    1991-01-01

    In September 1990, Martin Marietta Energy Systems (Energy Systems) discovered high levels of Cesium-137 ({sup 137}Cs) in surface sedimenus near the mouth of White Oak Creek Embayment (WOCE). White Oak Creek (WOC) receives surface water drainage from Oak Ridge National Laboratory. Since this discovery, the Department of Energy (DOE) and Energy Systems have pursued actions designed to stabilize the contaminated WOCE sediments under provisions of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), and the implementing regulations in the National Contingency Plan (NCP) (40 CFR Part 300), as a time-critical removal action. By definition, a time-critical removal is an action where onsite activities are initiated within six months of the determination that a removal action is appropriate. Time-critical removal actions allow comparatively rapid mobilization to protect human health and the environment without going through the lengthy and extensive CERCLA Remedial Investigation/Feasibility Study/Record of Decision process. Many aspects of the project, in terms of compliance with the substantive requirements of the NCP and ARARs, have exceeded the regulatory requirements, despite the fact that there is no apparent authority on conducting removal actions at Federal facilities. Much of the interpretation of the NCP was groundbreaking in nature for both EPA and DOE. 4 refs., 2 figs.

  3. Translating PrEP effectiveness into public health impact: key considerations for decision-makers on cost-effectiveness, price, regulatory issues, distributive justice and advocacy for access

    PubMed Central

    Hankins, Catherine; Macklin, Ruth; Warren, Mitchell

    2015-01-01

    Introduction The extraordinary feat of proving the effectiveness of oral pre-exposure prophylaxis (PrEP) in clinical trials in different populations in a variety of settings may prove to have been easier than ensuring it is used well. Decision-makers must make difficult choices to realize the promise of antiretroviral prophylaxis for their countries. This paper outlines key economic, regulatory and distributive justice issues that must be addressed for effective and acceptable PrEP implementation. Discussion In considering the role that PrEP can play in combination prevention programmes, decision-makers must determine who can benefit most from PrEP, how PrEP can be provided safely and efficiently, and what kind of health system support will ensure successful implementation. To do this, they need contextualized information on disease burden by population, analyses of how PrEP services might best be delivered, and projections of the human resource and infrastructure requirements for each potential delivery model. There are cost considerations, varying cost-effectiveness results and regulatory challenges. The principles of ethics can inform thorny discussions about who should be prioritized for oral PrEP and how best to introduce it fairly. We describe the cost-effectiveness of PrEP in different populations at higher risk of HIV exposure, its price in low- and middle-income countries, and the current regulatory situation. We explore the principles of ethics that can inform resource allocation decision-making about PrEP anchored in distributive justice, at a time when universal access to antiretroviral treatment remains to be assured. We then highlight the role of advocacy in moving the PrEP agenda forward. Conclusions The time is ripe now for decisions about whether, how and for whom PrEP should be introduced into a country's HIV response. It has the potential to contribute significantly to high impact HIV prevention if it is tailored to those who can most benefit

  4. Addressing healthcare.

    PubMed

    Daly, Rich

    2013-02-11

    Though President Barack Obama has rarely made healthcare references in his State of the Union addresses, health policy experts are hoping he changes that strategy this year. "The question is: Will he say anything? You would hope that he would, given that that was the major issue he started his presidency with," says Dr. James Weinstein, left, of the Dartmouth-Hitchcock health system. PMID:23487896

  5. Real-time earthquake alert system for the greater San Francisco Bay Area: a prototype design to address operational issues

    SciTech Connect

    Harben, P.E.; Jarpe, S.; Hunter, S.

    1996-12-10

    The purpose of the earthquake alert system (EAS) is to outrun the seismic energy released in a large earthquake using a geographically distributed network of strong motion sensors that telemeter data to a rapid CPU-processing station, which then issues an area-wide warning to a region before strong motion will occur. The warning times involved are short, from 0 to 30 seconds or so; consequently, most responses must be automated. The San Francisco Bay Area is particularly well suited for an EAS because (1) large earthquakes have relatively shallow hypocenters (10- to 20-kilometer depth), giving favorable ray-path geometries for larger warning times than deeper from earthquakes, and (2) the active faults are few in number and well characterized, which means far fewer geographically distributed strong motion sensors are (about 50 in this region). An EAS prototype is being implemented in the San Francisco Bay Area. The system consists of four distinct subsystems: (1) a distributed strong motion seismic network, (2) a central processing station, (3) a warning communications system and (4) user receiver and response systems. We have designed a simple, reliable, and inexpensive strong motion monitoring station that consists of a three-component Analog Devices ADXLO5 accelerometer sensing unit, a vertical component weak motion sensor for system testing, a 16-bit digitizer with multiplexing, and communication output ports for RS232 modem or radio telemetry. The unit is battery-powered and will be sited in fire stations. The prototype central computer analysis system consists of a PC dam-acquisition platform that pipes the incoming strong motion data via Ethernet to Unix-based workstations for dam processing. Simple real-time algorithms, particularly for magnitude estimation, are implemented to give estimates of the time since the earthquake`s onset its hypocenter location, its magnitude, and the reliability of the estimate. These parameters are calculated and transmitted

  6. Regulatory Issues and Challenges in Developing Seismic Source Characterizations for New Nuclear Power Plant Applications in the US

    NASA Astrophysics Data System (ADS)

    Fuller, C. W.; Unruh, J.; Lindvall, S.; Lettis, W.

    2009-05-01

    further complicated by: (1) a given applicant's uncertainty in how to revise the EPRI-SOG model, which was developed using a process similar to that dictated by SSHAC for a level 3 or 4 study, without conducting a resource-intensive SSHAC level 3 or higher study for their respective application; and (2) a lack of guidance from the NRC on acceptable methods of demonstrating that new data, interpretations, and opinions are adequately represented within the EPRI-SOG model. Partly because of these issues, initiative was taken by the nuclear industry, NRC and DOE to develop a new base PSHA model for the central and eastern US. However, this new SSC model will not be completed for several years and does not resolve many of the fundamental regulatory and philosophical issues that have been raised during the current round of applications. To ensure regulatory stability and to provide accurate estimates of hazard for nuclear power plants, a dialog must be started between regulators and industry to resolve these issues. Two key issues that must be discussed are: (1) should new data and new interpretations or opinions of old data be treated differently in updated SSCs, and if so, how?; and (2) how can new data or interpretations developed by a small subset of the technical community be weighed against and potentially combined with a SSC model that was originally developed to capture the "center, body and range" of the technical community?

  7. Subsurface Contaminant Focus Area: Monitored Natural Attenuation (MNA)--Programmatic, Technical, and Regulatory Issues

    SciTech Connect

    Krupka, Kenneth M.; Martin, Wayne J.

    2001-07-23

    Natural attenuation processes are commonly used for remediation of contaminated sites. A variety of natural processes occur without human intervention at all sites to varying rates and degrees of effectiveness to attenuate (decrease) the mass, toxicity, mobility, volume, or concentration of organic and inorganic contaminants in soil, groundwater, and surface water systems. The objective of this review is to identify potential technical investments to be incorporated in the Subsurface Contaminant Focus Area Strategic Plan for monitored natural attenuation. When implemented, the technical investments will help evaluate and implement monitored natural attenuation as a remediation option at DOE sites. The outcome of this review is a set of conclusions and general recommendations regarding research needs, programmatic guidance, and stakeholder issues pertaining to monitored natural attenuation for the DOE complex.

  8. Regulatory analysis for the resolution of Generic Safety Issue 29: Bolting degradation or failure in nuclear power plants

    SciTech Connect

    Chang, T.Y.

    1991-09-01

    Generic Safety Issue (GSI)-29 deals with staff concerns about public risk due to degradation or failure of safety-related bolting in nuclear power plants. The issue was initiated in November 1982. Value-impact studies of a mandatory program on safety-related bolting for operating plants were inconclusive: therefore, additional regulatory requirements for operating plants could not be justified in accordance with provisions of 10 CFR 50.109. In addition, based on operating experience with bolting in both nuclear and conventional power plants, the actions already taken through bulletins, generic letters, and information notices, and the industry-proposed actions, the staff concluded that a sufficient technical basis exists for the resolution of GSI-29. The staff further concluded that leakage of bolted pressure joints is possible but catastrophic failure of a reactor coolant pressure boundary joint that will lead to significant accident sequences is highly unlikely. For future plants, it was concluded that a new Standard Review Plant section should be developed to codify existing bolting requirements and industry-developed initiatives. 9 refs., 1 tab.

  9. Regulatory issues related to functional foods and natural health products in Canada: possible implications for manufacturers of conjugated linoleic acid.

    PubMed

    Fitzpatrick, Kelley C

    2004-06-01

    The Canadian Food and Drugs Act and Regulations, through its definitions of food and drug, currently restricts health-related claims for foods, food ingredients, and natural health products (NHPs). Over the past few decades, scientific research has led to a large body of information that demonstrates the benefits for health of many food and NHP ingredients. Health Canada recognized the constraints of the current regulatory environment and started to develop regulations related to the allowance of health claims for functional foods and NHPs, including those foods and NHPs that would contain conjugated linoleic acid isomers. Health Canada has 3 initiatives under way in the area of health claims for foods: 1) to adopt the generic health claims of the United States within a Canadian context, 2) to develop scientific standards of evidence and a guidance document for supporting the validity of product-specific claims, and 3) to develop an overall regulatory framework for functional foods. In 2000, Health Canada announced approval for the use of 5 generic diet-related health claims: sodium and hypertension, calcium and osteoporosis, saturated and trans fat and cholesterol and coronary artery disease, fruits and vegetables and cancer, and sugar alcohols and dental caries. Under a separate initiative, Natural Health Products Regulations were published in the Canada Gazette Part II on June 18, 2003. The NHP Regulations came into force on January 1, 2004, with a transition period ranging from 2 y (for site licensing) to 6 y (for product licensing, for products already issued a drug identification number). PMID:15159260

  10. Two regional regulatory meetings on distributed resources. Final technical report

    SciTech Connect

    2001-02-01

    An overview and discussion of Eastern Regional and Western Regional State Utility Regulators Workshops on Distributed Resources (DR) is given. The purpose of the workshops was for state regulators to learn about DR and the regulatory issues surrounding their greater use. The following issues were addressed: introduction to DR technologies and their potential benefits, interconnection and market barriers, regulatory incentives, rate design issues, and environmental issues.

  11. Enhancing capacities of riparian professionals to address and resolve transboundary issues in international river basins: experiences from the Lower Mekong River Basin

    NASA Astrophysics Data System (ADS)

    Douven, W.; Mul, M. L.; Álvarez, B. F.; Son, L. H.; Bakker, N.; Radosevich, G.; van der Zaag, P.

    2012-03-01

    This paper analyses the design and impact of capacity building programmes aimed at enhancing capacities of riparian professionals to address and resolve transboundary issues in international river basins. Case study is a programme developed by the Mekong River Commission (MRC). A post training evaluation was applied to assess its impact in terms of individual capacity enhancement and change (use and application of knowledge, factors hampering application, and change in function and opportunities within their organisation). The design of the Capacity Building Programme of the MRC Flood Management and Mitigation Programme showed a well balanced range of subjects (such as IWRM, models and decision support systems and international water law) which are required for such an integrated topic. The post training evaluation, 6 months after the last training workshop, showed the increase in familiarity of the topics for all 37 respondents, with highest increase for the respondents with few years of working experience and from training and educational institutions. The relevance of the subjects taught is shown by the fact that 95% of the respondents indicated they saw the relevance of the subjects and 78% had already used some knowledge acquired in their job. The respondents also indicated that they did not have sufficient opportunities to apply all knowledge acquired. The phased implementation and training of lecturers during the training workshops, had a good impact, directly through increasing involvement in facilitation and delivery of the capacity building programme and through the use of the knowledge gained in short courses and development of curricula at their training institute. For these types of capacity building programmes, a few recommendations can be made. The selection of participants is crucial for the application of the learned knowledge in their work. The integrative nature of transboundary water issues calls for a capacity building programme addressing a

  12. Enhancing capacities of riparian professionals to address and resolve transboundary issues in international river basins: experiences from the Lower Mekong River Basin

    NASA Astrophysics Data System (ADS)

    Douven, W.; Mul, M. L.; Fernández-Álvarez, B.; Hung, S. Lam; Bakker, N.; Radosevich, G.; van der Zaag, P.

    2012-09-01

    This paper analyses the design and impact of capacity building programmes aimed at enhancing capacities of riparian professionals to address and resolve transboundary issues in international river basins. The case study is a programme developed by the Mekong River Commission (MRC). A post-training evaluation was applied to assess its impact in terms of individual capacity enhancement and change (use and application of knowledge, factors hampering application, and change in function and opportunities within the organisation). The design of the Capacity Building Programme of the MRC Flood Management and Mitigation Programme required a well balanced range of subjects (such as IWRM (integrated water resources management), model and decision support systems, and international water law). The post-training evaluation, 6 months after the last training workshop, showed an increase in familiarity with the topics for all 37 respondents, with the highest increase for the respondents with few years of working experience and from training and education institutions. The relevance of the subjects taught was highlighted by 95% of the respondents, and 78% of the participants had already used some of the acquired knowledge in their job. The respondents indicated that they did not have sufficient opportunities to apply all knowledge. The phased implementation and training of lecturers during the training workshops had a good impact, directly through increasing involvement in facilitation and delivery of the capacity building programme and through the use of the knowledge gained in short courses and development of curricula at their institute. For these types of capacity building programmes, a few recommendations can be made. The selection of participants is crucial for the application of the learned knowledge in their work. The integrative nature of transboundary water issues calls for a capacity building programme addressing a wide range of subjects, which can be understood by a

  13. Regulatory analysis for the resolution of Generic Issue 143: Availability of chilled water system and room cooling

    SciTech Connect

    Leung, V.T.

    1993-12-01

    This report presents the regulatory analysis for Generic Issue (GI-143), {open_quotes}Availability of Chilled Water System and Room Cooling.{close_quotes} The heating, ventilating, and air conditioning (HVAC) systems and related auxiliaries are required to provide control of environmental conditions in areas in light water reactor (LWR) plants that contain safety-related equipment. In some plants, the HVAC and chilled water systems serve to maintain a suitable environment for both safety and non-safety-related areas. Although some plants have an independent chilled water system for the safety-related areas, the heat removal capability often depends on the operability of other supporting systems such as the service water system or the component cooling water system. The operability of safety-related components depends upon operation of the HVAC and chilled water systems to remove heat from areas containing the equipment. If cooling to dissipate the heat generated is unavailable, the ability of the safety-related equipment to operate as intended cannot be assured. Typical components or areas in the nuclear power plant that could be affected by the failure of cooling from HVAC or chilled water systems include the (1) emergency switchgear and battery rooms, (2) emergency diesel generator room, (3) pump rooms for residual heat removal, reactor core isolation cooling, high-pressure core spray, and low-pressure core spray, and (4) control room. The unavailability of such safety-related equipment or areas could cause the core damage frequency (CDF) to increase significantly.

  14. Regulatory aspects of oncology drug safety evaluation: Past practice, current issues, and the challenge of new drugs

    SciTech Connect

    Rosenfeldt, Hans; Kropp, Timothy; Benson, Kimberly; Ricci, M. Stacey; McGuinn, W. David; Verbois, S. Leigh

    2010-03-01

    The drug development of new anti-cancer agents is streamlined in response to the urgency of bringing effective drugs to market for patients with limited life expectancy. FDA's regulation of oncology drugs has evolved from the practices set forth in Arnold Lehman's seminal work published in the 1950s through the current drafting of a new International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) safety guidance for anti-cancer drug nonclinical evaluations. The ICH combines the efforts of the regulatory authorities of Europe, Japan, and the United States and the pharmaceutical industry from these three regions to streamline the scientific and technical aspects of drug development. The recent development of new oncology drug classes with novel mechanisms of action has improved survival rates for some cancers but also brings new challenges for safety evaluation. Here we present the legacy of Lehman and colleagues in the context of past and present oncology drug development practices and focus on some of the current issues at the center of an evolving harmonization process that will generate a new safety guidance for oncology drugs, ICH S9. The purpose of this new guidance will be to facilitate oncology drug development on a global scale by standardizing regional safety requirements.

  15. Regulatory and Permitting Issues

    SciTech Connect

    Larry Myer

    2005-12-01

    As part of the West Coast Regional Carbon Sequestration Partnership (WESTCARB), Terralog Technologies USA, Inc., reviewed current state and federal regulations related to carbon dioxide capture and storage within geologic formations and enhanced carbon uptake in terrestrial ecosystems. We have evaluated and summarized the current and possible future permitting requirements for the six states that comprise the West Coast Regional Partnership. Four options exist for CO{sub 2} injection into appropriate geologic formations, including storage in: (1) oil and gas reservoirs, (2) saline formations, (3) unmineable coal beds, and (4) salt caverns. Terrestrial CO{sub 2} sequestration involves improved carbon conservation management (e.g. reduction of deforestation), carbon substitution (e.g., substitution for fossil fuel-based products, energy conservation through urban forestry, biomass for energy generation), and improved carbon storage management (e.g., expanding the storage of carbon in forest ecosystems). The primary terrestrial options for the West Coast Region include: (1) reforestation of under-producing lands (including streamside forest restoration), (2) improved forest management, (3) forest protection and conservation, and (4) fuel treatments for the reduction of risk of uncharacteristically severe fires (potentially with associated biomass energy generation). The permits and/or contracts required for any land-use changes/disturbances and biomass energy generation that may occur as part of WESTCARB's activities have been summarized for each state.

  16. Multiaxial Creep-Fatigue and Creep-Ratcheting Failures of Grade 91 and Haynes 230 Alloys Toward Addressing Design Issues of Gen IV Nuclear Power Plants

    SciTech Connect

    Hassan, Tasnim; Lissenden, Cliff; Carroll, Laura

    2015-04-01

    The proposed research will develop systematic sets of uniaxial and multiaxial experimental data at a very high temperature (850-950°C) for Alloy 617. The loading histories to be prescribed in the experiments will induce creep-fatigue and creep-ratcheting failure mechanisms. These experimental responses will be scrutinized in order to quantify the influences of temperature and creep on fatigue and ratcheting failures. A unified constitutive model (UCM) will be developed and validated against these experimental responses. The improved UCM will be incorporated into the widely used finite element commercial software packages ANSYS. The modified ANSYS will be validated so that it can be used for evaluating the very high temperature ASME-NH design-by-analysis methodology for Alloy 617 and thereby addressing the ASME-NH design code issues.

  17. Rationales for regulatory activity

    SciTech Connect

    Perhac, R.M.

    1997-02-01

    The author provides an outline which touches on the types of concerns about risk evaluation which are addressed in the process of establishing regulatory guides. Broadly he says regulatory activity serves three broad constituents: (1) Paternalism (private risk); (2) Promotion of social welfare (public risks); (3) Protection of individual rights (public risks). He then discusses some of the major issues encountered in reaching a decision on what is an acceptable level of risk within each of these areas, and how one establishes such a level.

  18. How agro-ecological research helps to address food security issues under new IPM and pesticide reduction policies for global crop production systems.

    PubMed

    E Birch, A Nicholas; Begg, Graham S; Squire, Geoffrey R

    2011-06-01

    Drivers behind food security and crop protection issues are discussed in relation to food losses caused by pests. Pests globally consume food estimated to feed an additional one billion people. Key drivers include rapid human population increase, climate change, loss of beneficial on-farm biodiversity, reduction in per capita cropped land, water shortages, and EU pesticide withdrawals under policies relating to 91/414 EEC. IPM (Integrated Pest Management) will be compulsory for all EU agriculture by 2014 and is also being widely adopted globally. IPM offers a 'toolbox' of complementary crop- and region-specific crop protection solutions to address these rising pressures. IPM aims for more sustainable solutions by using complementary technologies. The applied research challenge now is to reduce selection pressure on single solution strategies, by creating additive/synergistic interactions between IPM components. IPM is compatible with organic, conventional, and GM cropping systems and is flexible, allowing regional fine-tuning. It reduces pests below economic thresholds utilizing key 'ecological services', particularly biocontrol. A recent global review demonstrates that IPM can reduce pesticide use and increase yields of most of the major crops studied. Landscape scale 'ecological engineering', together with genetic improvement of new crop varieties, will enhance the durability of pest-resistant cultivars (conventional and GM). IPM will also promote compatibility with semiochemicals, biopesticides, precision pest monitoring tools, and rapid diagnostics. These combined strategies are urgently needed and are best achieved via multi-disciplinary research, including complex spatio-temporal modelling at farm and landscape scales. Integrative and synergistic use of existing and new IPM technologies will help meet future food production needs more sustainably in developed and developing countries, in an era of reduced pesticide availability. Current IPM research gaps are

  19. The role and activities of the ISCT Regulatory Affairs Committee.

    PubMed

    Kelley, L

    2003-01-01

    The following article is written as part of a series of reviews addressing regulatory issues relevant to the field of cellular therapy. The first in the series describes the activities and mission of the Legal and Regulatory Affairs Committee of ISCT. PMID:12944232

  20. Toward improving hurricane forecasts using the JPL Tropical Cyclone Information System (TCIS): A framework to address the issues of Big Data

    NASA Astrophysics Data System (ADS)

    Hristova-Veleva, S. M.; Boothe, M.; Gopalakrishnan, S.; Haddad, Z. S.; Knosp, B.; Lambrigtsen, B.; Li, P.; montgomery, M. T.; Niamsuwan, N.; Tallapragada, V. S.; Tanelli, S.; Turk, J.; Vukicevic, T.

    2013-12-01

    Accurate forecasting of extreme weather requires the use of both regional models as well as global General Circulation Models (GCMs). The regional models have higher resolution and more accurate physics - two critical components needed for properly representing the key convective processes. GCMs, on the other hand, have better depiction of the large-scale environment and, thus, are necessary for properly capturing the important scale interactions. But how to evaluate the models, understand their shortcomings and improve them? Satellite observations can provide invaluable information. And this is where the issues of Big Data come: satellite observations are very complex and have large variety while model forecast are very voluminous. We are developing a system - TCIS - that addresses the issues of model evaluation and process understanding with the goal of improving the accuracy of hurricane forecasts. This NASA/ESTO/AIST-funded project aims at bringing satellite/airborne observations and model forecasts into a common system and developing on-line tools for joint analysis. To properly evaluate the models we go beyond the comparison of the geophysical fields. We input the model fields into instrument simulators (NEOS3, CRTM, etc.) and compute synthetic observations for a more direct comparison to the observed parameters. In this presentation we will start by describing the scientific questions. We will then outline our current framework to provide fusion of models and observations. Next, we will illustrate how the system can be used to evaluate several models (HWRF, GFS, ECMWF) by applying a couple of our analysis tools to several hurricanes observed during the 2013 season. Finally, we will outline our future plans. Our goal is to go beyond the image comparison and point-by-point statistics, by focusing instead on understanding multi-parameter correlations and providing robust statistics. By developing on-line analysis tools, our framework will allow for consistent

  1. Innovative Legal Approaches to Address Obesity

    PubMed Central

    Pomeranz, Jennifer L; Teret, Stephen P; Sugarman, Stephen D; Rutkow, Lainie; Brownell, Kelly D

    2009-01-01

    Context: The law is a powerful public health tool with considerable potential to address the obesity issue. Scientific advances, gaps in the current regulatory environment, and new ways of conceptualizing rights and responsibilities offer a foundation for legal innovation. Methods: This article connects developments in public health and nutrition with legal advances to define promising avenues for preventing obesity through the application of the law. Findings: Two sets of approaches are defined: (1) direct application of the law to factors known to contribute to obesity and (2) original and innovative legal solutions that address the weak regulatory stance of government and the ineffectiveness of existing policies used to control obesity. Specific legal strategies are discussed for limiting children's food marketing, confronting the potential addictive properties of food, compelling industry speech, increasing government speech, regulating conduct, using tort litigation, applying nuisance law as a litigation strategy, and considering performance-based regulation as an alternative to typical regulatory actions. Finally, preemption is an overriding issue and can play both a facilitative and a hindering role in obesity policy. Conclusions: Legal solutions are immediately available to the government to address obesity and should be considered at the federal, state, and local levels. New and innovative legal solutions represent opportunities to take the law in creative directions and to link legal, nutrition, and public health communities in constructive ways. PMID:19298420

  2. Regulatory and Technical Issues Concerning the Detection and Treatment of NDMA-Contaminated Groundwater at NASA WSTF

    NASA Technical Reports Server (NTRS)

    Wiebe, D. T.; Zigmond, M. J.; Tufts, C. A.

    2002-01-01

    The National Aeronautics and Space Administration (NASA) White Sands Test Facility (WSTF) was established in 1963 primarily to provide rocket engine testing services for several NASA programs. The groundwater underlying the site has been contaminated as a result of historical operations. Groundwater contaminants include several volatile organic compounds (VOCs) and two semi-volatile compounds: N-nitrosodimethylamine (NDMA) and N-nitrodimethylamine (DMN). This paper discusses some of the technical, analytical, regulatory, and health risk issues associated with the contaminant plume. The plume has moved approximately 2.5 miles downgradient of the facility industrial boundary, with evidence of continued migration. As a result, NASA has proposed a pump and treat system using air strippers and ultraviolet (UV) oxidation to stabilize future movement of the contaminant plume. The system has been designed to treat 1,076 gallons (4,073 liters) per minute, with provisions for future expansion. The UV oxidation process was selected to treat NDMA-contaminated groundwater based on successes at other NDMA-contaminated sites. Bench- and pilot-scale testing of WSTF groundwater confirmed the ability of UV oxidation to destroy NDMA and generated sufficient data to design the proposed full-scale treatment system. NDMA is acutely toxic and is a probable human carcinogen. EPA-recommended health risk criteria for the residential consumption of NDMA/DMN-contaminated groundwater was used to determine that a 1.0 x 10(exp -6) excess cancer risk corresponds to 1.7 parts per trillion (ppt). EPA analytical methods are unable to detect NDMA and DMN in the low ppt range. EPA's current Appendix IX analytical method used to screen for NDMA, Method 8270, can detect NDMA only at levels that are orders of magnitude greater than the recommended health risk level. Additionally, EPA Method 607, the most sensitive EPA approved method, has a detection limit of 150 ppt. This corresponds to an excess cancer

  3. Proceedings of the tenth annual DOE low-level waste management conference: Session 1: Institutional and regulatory issues

    SciTech Connect

    Not Available

    1988-12-01

    This document contains eleven papers on various aspects of low-level radioactive waste regulation. Topics include: EPA environmental standards; international exemption principles; the concept of below regulatory concern; envirocare activities in Utah; mixed waste; FUSRAP and the Superfund; and a review of various incentive programs. Individual papers are processed separately for the data base. (TEM)

  4. From work plan to rod and beyond: Lessons learned on regulatory issues at the Weldon Spring Site

    SciTech Connect

    MacDonell, M.; Peterson, J.; Uhlmeyer, T.; Ferguson, R.

    1993-11-01

    Compliance with applicable or relevant and appropriate requirements (ARARs) is a key element of successful cleanup activities at environmental restoration sites. A number of ARAR issues were raised during the, planning, assessment, and implementation of restoration activities at a US Department of Energy (DOE) mixed waste site in Missouri. Resolutions were developed for issues ranging from storage time requirements to land disposal restrictions. This paper discusses ARAR issues and resolutions.

  5. The Platte River - High Plains Aquifer (PR-HPA) Long Term Agroecosystem Research (LTAR) Network - Data and Technological Resources to Address Current and Emerging Issues in Agroecosystems.

    NASA Astrophysics Data System (ADS)

    Okalebo, J. A.; Wienhold, B.; Suyker, A.; Erickson, G.; Hayes, M. J.; Awada, T.

    2015-12-01

    The Platte River - High Plains Aquifer (PR-HPA) is one of 18 established Long Term Agroecosystem Research (LTAR) networks across the US. PR-HPA is a partnership between the Institute of Agriculture and Natural Resources at the University of Nebraska-Lincoln (UNL), the USDA-ARS Agroecosystem Management Research Unit (AMRU) in Lincoln, and the USDA-ARS Environmental Management Research Unit (EMRU) in Clay Center, NE. The PR-HPA network encompasses 27,750 ha of research sites with data going back to the early 1900s. A partial list of on-going research projects include those encompassing long-term manuring and continuous corn (Est. 1912), dryland tillage plots (Est. 1970), soil nutrients and tillage (Est. 1983), biofuel feedstock studies (Est. 2001), and carbon sequestration study (Est. 2000). Affiliated partners include the National Drought Mitigation Center (NDMC) that develops measures to improve preparedness and adaptation to climate variability and drought; the High Plains Regional Climate Center (HPRCC) that coordinates data acquisition from over 170 automated weather stations and around 50 automated soil moisture network across NE and beyond; the AMERIFLUX and NEBFLUX networks that coordinate the water vapor and carbon dioxide flux measurements across NE with emphasis on rainfed and irrigated crop lands; the ARS Greenhouse gas Reduction through Agricultural Carbon Enhancement network (GRACEnet) and the Resilient Economic Agricultural Practices (REAP) project; and the Center for Advanced Land Management Information Technologies (CALMIT) that assists with the use of geospatial technologies for agriculture and natural resource applications. Current emphases are on addressing present-day and emerging issues related to profitability and sustainability of agroecosystems. The poster will highlight some of the ongoing and planned efforts in research pertaining to climate variability and change, water sustainability, and ecological and agronomic challenges associated

  6. Interactions between the stratum corneum and topically applied products: regulatory, instrumental and formulation issues with focus on moisturizers.

    PubMed

    Lodén, M

    2014-09-01

    Virtually everyone in Europe will use at least one cosmetic product every day. The extensive use of cosmetics and results from measurements of quality of life in patients with skin diseases demonstrate the importance of a healthy skin. The skin is not only a barrier against desiccation and intrusion of harmful materials, but also an organ of social communication, where dry, scaly, rough stratum corneum is unappealing to touch, inducing anxiety and depression. Knowledge about the skin biochemistry and the use of noninvasive instruments facilitate the development of topical products and quantification of their effects. The presentation of the products and mode of action determine the regulatory demands and the approval process, as they can fall into different regulatory entities, such as cosmetics, medicinal products, medical devices and as other chemical products. The majority of the topical products on the market are regulated as cosmetics. For example, facial skin care and daily moisturizing routines are frequently used. However, despite visible relief of dryness symptoms, some products are reported to result in deterioration of the skin barrier function. New clinical outcomes show important clinical differences between formulations and the relapse of eczema. In a worst case scenario, treatment with a moisturizing cream may increase the risks of eczema and asthma. In the present overview, product presentations and mode of actions are reflected against the regulatory demands in Europe. The regulations are continuously revisited and new guidelines are being implemented, such as the new cosmetic regulation with advice on testing and responsible marketing. PMID:25040916

  7. Challenging the One-Way Paradigm for More Effective Science Communication: A Critical Review of Two Public Campaigns Addressing Contentious Environmental Issues

    ERIC Educational Resources Information Center

    McEntee, Marie; Mortimer, Claire

    2013-01-01

    This article examines two large-scale public communication campaigns to explore the appropriateness and effectiveness of using one-way communication in contentious environmental issues. The findings show while one-way communication can be successfully employed in contentious issues, it is not appropriate for all contexts and may contribute to…

  8. Recommended Changes to the No Child Left Behind Act to Address Workforce Issues. Submitted to the House Subcommittee on Higher Education, Lifelong Learning, and Competitiveness of the Committee on Education and Labor

    ERIC Educational Resources Information Center

    Harris, Linda; Tsoi-A-Fatt, Rhonda

    2007-01-01

    This paper presents Center for Law and Social Policy's (CLASP's) recommendations on how No Child Left Behind (NCLB) could better address the workforce challenges faced by this country. CLASP is a nonprofit organization engaged in research, analysis, technical assistance, and advocacy on a range of issues affecting low-income families. The…

  9. Bringing Out the Best in All Our Students. Partnerships/Goals 2000, Consortia Addressing Statewide Systemic Issues (CASSI) Grants and Local Improvement (LIG) Grants Progress Reports, 1995-1998.

    ERIC Educational Resources Information Center

    Colorado Education Goals Panel, Denver.

    This report summarizes the accomplishments of local education grants that have balanced the need for high standards, accountability, parent involvement, and flexibility. The document examines results from two funding opportunities supported by the Goals 2000 Educate America Act: the Consortia Addressing Statewide Systemic Issues (CASSI) and Local…

  10. Current and new developments in transport and regulatory issues concerning radioisotopes: managing change for minimum business impact

    NASA Astrophysics Data System (ADS)

    Bennett, Neil; Coppell, David; Rogers, David; Schrader, John

    2004-09-01

    Changes in the regulatory framework governing the Radiation Processing Industry have the potential to make a real business impact on day-to-day profitability. Many areas of the Radiation Processing Industry are affected by changes in the regulatory framework within which these areas are managed. When planning for such changes the transportation element in the shipment of sealed cobalt radiation sources is an area that is often neglected by some parts of the distribution chain. A balance must be struck between the cobalt supplier and the facility operator/customer that rests upon how much the customer needs to know about the intricacies of cobalt shipment. The objective of this paper is to highlight areas of possible business impact and reassure the users of sealed radiation sources that the global suppliers of these products are used to negotiating local variations in regulations governing the physical transportation of radiation sources, changes in regulations governing the design, manufacture and use of transportation containers and changes in the availability of commercial shippers and shipping routes. The major suppliers of industrial quantities of cobalt-60 are well placed to lead their customers through this complex process as a matter of routine.

  11. Religion, Spirituality, and Marriage and Family Therapy: A Study of Family Therapists' Beliefs about the Appropriateness of Addressing Religious and Spiritual Issues in Therapy.

    ERIC Educational Resources Information Center

    Carlson, Thomas D.; Kirkpatrick, Dwight; Hecker, Lorna; Killmer, Mark

    2002-01-01

    Although increasing attention has been given to spirituality, to date, no published studies in marriage and family therapy journals have explored marriage and family therapists' beliefs about the appropriateness of addressing spirituality in therapy. This study fills this gap by examining the beliefs of a sample of clinical members of AAMFT about…

  12. Chopsticks Don't Make It Culturally Competent: Addressing Larger Issues for HIV Prevention among Gay, Bisexual, and Queer Asian Pacific Islander Men

    ERIC Educational Resources Information Center

    Han, Chong-suk

    2009-01-01

    According to the Centers for Disease Control and Prevention, men who have sex with men account for the largest proportion of cumulative AIDS cases among Asian Pacific Islanders. Yet little is known about the factors that need to be addressed in developing culturally competent intervention strategies for members of this group. This article explores…

  13. The Design and Evaluation of a Teaching-Learning Sequence Addressing the Solubility Concept with Turkish Secondary School Students. Special Issue

    ERIC Educational Resources Information Center

    Kabapinar, Filiz; Leach, John; Scott, Phil

    2004-01-01

    This paper reports upon a study addressing teaching and learning about solubility to Turkish first-year secondary school students (age 14-15). The principal aim of the research was to investigate the impact on students' understanding of solubility, of introducing a simple particle model of matter. A teaching intervention to fit within the existing…

  14. Religious Congregations' Collaborations: With Whom Do They Work and What Resources Do They Share in Addressing HIV and Other Health Issues?

    ERIC Educational Resources Information Center

    Werber, Laura; Derose, Kathryn Pitkin; Dominguez, Blanca X.; Mata, Michael A.

    2012-01-01

    This study explores how religious congregations interact with other community organizations to address health and, in particular, HIV-related needs within their membership and/or local communities. Case study data from a diverse sample of 14 urban congregations (6 Black, 4 Latino, 2 White, and 2 mixed race-ethnicity) indicate that they engaged in…

  15. Addressing Racism

    ERIC Educational Resources Information Center

    Journal for Research in Mathematics Education, 2013

    2013-01-01

    This dialogue, extracted from a conversation among some members of the Equity Special Issue Editorial Panel, concerns racism in mathematics education. It raises issues about the use of various terms; about fields of research outside of mathematics education; and about the kinds of racialization processes that occur for students, teachers, and…

  16. Project 10 Handbook: Addressing Lesbian and Gay Issues in Our Schools. A Resource Directory for Teachers, Guidance Counselors, Parents and School-Based Adolescent Care Providers. Third Edition.

    ERIC Educational Resources Information Center

    Friends of Project 10, Inc.

    This handbook was developed by Project 10, an on-campus counseling program within the Los Angeles (California) Unified School District. The handbook covers many of the issues and problems that arise for homosexual high school students. Introductory material includes a history of the informal beginnings of Project 10. The first chapter describes…

  17. Front-burner issues: A round-up of some of the gas industry's latest state legislative and regulatory concerns

    SciTech Connect

    Alexander, C.B.

    1994-10-01

    In the last full session of Congress, 103 public laws were passed and 4,369 regulations were issued by federal agencies. Implementation of many of them is up to the states. Some congressional monitors say that you can predict a state's agenda two to four years from now by watching what's going on in Congress today. Some of the issues discussed here are: one-call systems which establish a single phone number throughout a state that excavators must call before they dig; the Alliance for Fair Utility Competition and the selling and servicing of appliances; standby charges for dual-fuel heating customers; implementation of the Clean Act Amendments by state governments; use of alternative-fuel vehicles and the incentives to set up fueling stations; and unfunded mandates from the federal government.

  18. Genomics in the land of regulatory science.

    PubMed

    Tong, Weida; Ostroff, Stephen; Blais, Burton; Silva, Primal; Dubuc, Martine; Healy, Marion; Slikker, William

    2015-06-01

    Genomics science has played a major role in the generation of new knowledge in the basic research arena, and currently question arises as to its potential to support regulatory processes. However, the integration of genomics in the regulatory decision-making process requires rigorous assessment and would benefit from consensus amongst international partners and research communities. To that end, the Global Coalition for Regulatory Science Research (GCRSR) hosted the fourth Global Summit on Regulatory Science (GSRS2014) to discuss the role of genomics in regulatory decision making, with a specific emphasis on applications in food safety and medical product development. Challenges and issues were discussed in the context of developing an international consensus for objective criteria in the analysis, interpretation and reporting of genomics data with an emphasis on transparency, traceability and "fitness for purpose" for the intended application. It was recognized that there is a need for a global path in the establishment of a regulatory bioinformatics framework for the development of transparent, reliable, reproducible and auditable processes in the management of food and medical product safety risks. It was also recognized that training is an important mechanism in achieving internationally consistent outcomes. GSRS2014 provided an effective venue for regulators andresearchers to meet, discuss common issues, and develop collaborations to address the challenges posed by the application of genomics to regulatory science, with the ultimate goal of wisely integrating novel technical innovations into regulatory decision-making. PMID:25796433

  19. Academic Institutions and One Health: Building Capacity for Transdisciplinary Research Approaches to Address Complex Health Issues at the Animal–Human–Ecosystem Interface

    PubMed Central

    Allen-Scott, Lisa K.; Buntain, Bonnie; Hatfield, Jennifer M.; Meisser, Andrea

    2015-01-01

    To improve health at the human, animal, and ecosystem interface, defined as One Health, training of researchers must transcend individual disciplines to develop a new process of collaboration. The transdisciplinary research approach integrates frameworks and methodologies beyond academic disciplines and includes involvement of and input from policy makers and members of the community. The authors argue that there should be a significant shift in academic institutions’ research capacity to achieve the added value of a transdisciplinary approach for addressing One Health problems. This Perspective is a call to action for academic institutions to provide the foundations for this salient shift. The authors begin by describing the transdisciplinary approach, propose methods for building transdisciplinary research capacity, and highlight three value propositions that support the case. Examples are provided to illustrate how the transdisciplinary approach to research adds value through improved sustainability of impact, increased cost-effectiveness, and enhanced abilities to mitigate potentially harmful unintended consequences. The authors conclude with three key recommendations for academic institutions: (1) a focus on creating enabling environments for One Health and transdisciplinary research, (2) the development of novel funding structures for transdisciplinary research, and (3) training of “transmitters” using real-world-oriented educational programs that break down research silos through collaboration across disciplines. PMID:25650827

  20. Advanced alarm systems: Display and processing issues

    SciTech Connect

    O`Hara, J.M.; Wachtel, J.; Perensky, J.

    1995-05-01

    This paper describes a research program sponsored by the US Nuclear Regulatory Commission to address the human factors engineering (HFE) deficiencies associated with nuclear power plant alarm systems. The overall objective of the study is to develop HFE review guidance for alarm systems. In support of this objective, human performance issues needing additional research were identified. Among the important issues were alarm processing strategies and alarm display techniques. This paper will discuss these issues and briefly describe our current research plan to address them.

  1. Nuclear economics: Issues and facts

    SciTech Connect

    Hudson, C.R.

    1993-12-31

    Nuclear economics has become on the more prominent topics related to nuclear power. Beyond the subjects of nuclear safety and waste disposal, questions and concerns of nuclear power economics have emerged with growing frequency in utility board rooms, in state and federal regulatory proceedings, and in the media. What has caused nuclear power economics to become such a popular topic? This paper addresses issues and facts related to historical nuclear plant costs, new nuclear plant projections, and warning signals for future plants.

  2. Inaugural address

    NASA Astrophysics Data System (ADS)

    Joshi, P. S.

    2014-03-01

    From jets to cosmos to cosmic censorship P S Joshi Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India E-mail: psj@tifr.res.in 1. Introduction At the outset, I should like to acknowledge that part of the title above, which tries to capture the main flavour of this meeting, and has been borrowed from one of the plenary talks at the conference. When we set out to make the programme for the conference, we thought of beginning with observations on the Universe, but then we certainly wanted to go further and address deeper questions, which were at the very foundations of our inquiry, and understanding on the nature and structure of the Universe. I believe, we succeeded to a good extent, and it is all here for you in the form of these Conference Proceedings, which have been aptly titled as 'Vishwa Mimansa', which could be possibly translated as 'Analysis of the Universe'! It is my great pleasure and privilege to welcome you all to the ICGC-2011 meeting at Goa. The International Conference on Gravitation and Cosmology (ICGC) series of meetings are being organized by the Indian Association for General Relativity and Gravitation (IAGRG), and the first such meeting was planned and conducted in Goa in 1987, with subsequent meetings taking place at a duration of about four years at various locations in India. So, it was thought appropriate to return to Goa to celebrate the 25 years of the ICGC meetings. The recollections from that first meeting have been recorded elsewhere here in these Proceedings. The research and teaching on gravitation and cosmology was initiated quite early in India, by V V Narlikar at the Banares Hindu University, and by N R Sen in Kolkata in the 1930s. In course of time, this activity grew and gained momentum, and in early 1969, at the felicitation held for the 60 years of V V Narlikar at a conference in Ahmedabad, P C Vaidya proposed the formation of the IAGRG society, with V V Narlikar being the first President. This

  3. Opening addresses.

    PubMed

    Chukudebelu, W O; Lucas, A O; Ransome-kuti, O; Akinla, O; Obayi, G U

    1988-01-01

    The theme of the 3rd International Conference of the Society of Gynecology and Obstetrics of Nigeria (SOGON) held October 26, 1986 in Enugu was maternal morbidity and mortality in Africa. The opening addresses emphasize the high maternal mortality rate in Africa and SOGON's dedication to promoting women's health and welfare. In order to reduce maternal mortality, the scope of this problem must be made evident by gathering accurate mortality rates through maternity care monitoring and auditing. Governments, health professionals, educators, behavioral scientists, and communication specialists have a responsibility to improve maternal health services in this country. By making the population aware of this problem through education, measures can be taken to reduce the presently high maternal mortality rates. Nigerian women are physically unprepared for childbirth; therefore, balanced diets and disease prevention should be promoted. Since about 40% of deliveries are unmanaged, training for traditional birth attendants should be provided. Furthermore, family planning programs should discourage teenage pregnancies, encourage birth spacing and small families, and promote the use of family planning techniques among men. The problem of child bearing and rearing accompanied by hard work should also be investigated. For practices to change so that maternal mortality rates can be reduced, attitudes must be changed such that the current rates are viewed as unacceptable. PMID:12179275

  4. Opening Address

    NASA Astrophysics Data System (ADS)

    Yamada, T.

    2014-12-01

    Ladies and Gentlemen, it is my great honor and pleasure to present an opening address of the 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3). On the behalf of the organizing committee, I certainly welcome all your visits to KGU Kannai Media Center belonging to Kanto Gakuin University, and stay in Yokohama. In particular, to whom come from abroad more than 17 countries, I would appreciate your participations after long long trips from your homeland to Yokohama. The first international workshop on "State of the Art in Nuclear Cluster Physics", called SOTANCP, was held in Strasbourg, France, in 2008, and the second one was held in Brussels, Belgium, in 2010. Then the third workshop is now held in Yokohama. In this period, we had the traditional 10th cluster conference in Debrecen, Hungary, in 2012. Thus we have the traditional cluster conference and SOTANCP, one after another, every two years. This obviously shows our field of nuclear cluster physics is very active and flourishing. It is for the first time in about 10 years to hold the international workshop on nuclear cluster physics in Japan, because the last cluster conference held in Japan was in Nara in 2003, about 10 years ago. The president in Nara conference was Prof. K. Ikeda, and the chairpersons were Prof. H. Horiuchi and Prof. I. Tanihata. I think, quite a lot of persons in this room had participated at the Nara conference. Since then, about ten years passed. So, this workshop has profound significance for our Japanese colleagues. The subjects of this workshop are to discuss "the state of the art in nuclear cluster physics" and also discuss the prospect of this field. In a couple of years, we saw significant progresses of this field both in theory and in experiment, which have brought better and new understandings on the clustering aspects in stable and unstable nuclei. I think, the concept of clustering has been more important than ever. This is true also in the

  5. Presidential address.

    PubMed

    Vohra, U

    1993-07-01

    The Secretary of India's Ministry of Health and Family Welfare serves as Chair of the Executive Council of the International Institute for Population Sciences in Bombay. She addressed its 35th convocation in 1993. Global population stands at 5.43 billion and increases by about 90 million people each year. 84 million of these new people are born in developing countries. India contributes 17 million new people annually. The annual population growth rate in India is about 2%. Its population size will probably surpass 1 billion by the 2000. High population growth rates are a leading obstacle to socioeconomic development in developing countries. Governments of many developing countries recognize this problem and have expanded their family planning programs to stabilize population growth. Asian countries that have done so and have completed the fertility transition include China, Japan, Singapore, South Korea, and Thailand. Burma, Malaysia, North Korea, Sri Lanka, and Vietnam have not yet completed the transition. Afghanistan, Bangladesh, Iran, Nepal, and Pakistan are half-way through the transition. High population growth rates put pressure on land by fragmenting finite land resources, increasing the number of landless laborers and unemployment, and by causing considerable rural-urban migration. All these factors bring about social stress and burden civic services. India has reduced its total fertility rate from 5.2 to 3.9 between 1971 and 1991. Some Indian states have already achieved replacement fertility. Considerable disparity in socioeconomic development exists among states and districts. For example, the states of Bihar, Madhya Pradesh, Rajasthan, and Uttar Pradesh have female literacy rates lower than 27%, while that for Kerala is 87%. Overall, infant mortality has fallen from 110 to 80 between 1981 and 1990. In Uttar Pradesh, it has fallen from 150 to 98, while it is at 17 in Kerala. India needs innovative approaches to increase contraceptive prevalence rates

  6. Regulatory aspects on nanomedicines.

    PubMed

    Sainz, Vanessa; Conniot, João; Matos, Ana I; Peres, Carina; Zupancic, Eva; Moura, Liane; Silva, Liana C; Florindo, Helena F; Gaspar, Rogério S

    2015-12-18

    Nanomedicines have been in the forefront of pharmaceutical research in the last decades, creating new challenges for research community, industry, and regulators. There is a strong demand for the fast development of scientific and technological tools to address unmet medical needs, thus improving human health care and life quality. Tremendous advances in the biomaterials and nanotechnology fields have prompted their use as promising tools to overcome important drawbacks, mostly associated to the non-specific effects of conventional therapeutic approaches. However, the wide range of application of nanomedicines demands a profound knowledge and characterization of these complex products. Their properties need to be extensively understood to avoid unpredicted effects on patients, such as potential immune reactivity. Research policy and alliances have been bringing together scientists, regulators, industry, and, more frequently in recent years, patient representatives and patient advocacy institutions. In order to successfully enhance the development of new technologies, improved strategies for research-based corporate organizations, more integrated research tools dealing with appropriate translational requirements aiming at clinical development, and proactive regulatory policies are essential in the near future. This review focuses on the most important aspects currently recognized as key factors for the regulation of nanomedicines, discussing the efforts under development by industry and regulatory agencies to promote their translation into the market. Regulatory Science aspects driving a faster and safer development of nanomedicines will be a central issue for the next years. PMID:26260323

  7. Welcome Address

    NASA Astrophysics Data System (ADS)

    Kiku, H.

    2014-12-01

    Ladies and Gentlemen, It is an honor for me to present my welcome address in the 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3), as the president of Kanto Gakuin University. Particularly to those from abroad more than 17 countries, I am very grateful for your participation after long long trips from your home to Yokohama. On the behalf of the Kanto Gakuin University, we certainly welcome your visit to our university and stay in Yokohama. First I would like to introduce Kanto Gakuin University briefly. Kanto Gakuin University, which is called KGU, traces its roots back to the Yokohama Baptist Seminary founded in 1884 in Yamate, Yokohama. The seminary's founder was Albert Arnold Bennett, alumnus of Brown University, who came to Japan from the United States to establish a theological seminary for cultivating and training Japanese missionaries. Now KGU is a major member of the Kanto Gakuin School Corporation, which is composed of two kindergartens, two primary schools, two junior high schools, two senior high schools as well as KGU. In this university, we have eight faculties with graduate school including Humanities, Economics, Law, Sciences and Engineering, Architecture and Environmental Design, Human and Environmental Studies, Nursing, and Law School. Over eleven thousands students are currently learning in our university. By the way, my major is the geotechnical engineering, and I belong to the faculty of Sciences and Engineering in my university. Prof. T. Yamada, here, is my colleague in the same faculty. I know that the nuclear physics is one of the most active academic fields in the world. In fact, about half of the participants, namely, more than 50 scientists, come from abroad in this conference. Moreover, I know that the nuclear physics is related to not only the other fundamental physics such as the elementary particle physics and astrophysics but also chemistry, medical sciences, medical cares, and radiation metrology

  8. Space Station Engineering Design Issues

    NASA Technical Reports Server (NTRS)

    Mcruer, Duane T.; Boehm, Barry W.; Debra, Daniel B.; Green, C. Cordell; Henry, Richard C.; Maycock, Paul D.; Mcelroy, John H.; Pierce, Chester M.; Stafford, Thomas P.; Young, Laurence R.

    1989-01-01

    Space Station Freedom topics addressed include: general design issues; issues related to utilization and operations; issues related to systems requirements and design; and management issues relevant to design.

  9. Addressing Cyberbullying as a Media Literacy Issue

    ERIC Educational Resources Information Center

    Bhat, Christine Suniti; Chang, Shih-Hua; Linscott, Jamie A.

    2010-01-01

    Background: The Asian region accounts for the highest number of internet and mobile cell phones consumers among the regions of the world. As the use of information and communications technology becomes more and more widespread, the misuse of such technology becomes a concern. Cyberbullying, or bullying using information and communications…

  10. Addressing hypertext design and conversion issues

    NASA Technical Reports Server (NTRS)

    Glusko, Robert J.

    1990-01-01

    Hypertext is a network of information units connected by relational links. A hypertext system is a configuration of hardware and software that presents a hypertext to users and allows them to manage and access the information that it contains. Hypertext is also a user interface concept that closely supports the ways that people use printed information. Hypertext concepts encourage modularity and the elimination of redundancy in data bases because information can be stored only once but viewed in any appropriate context. Hypertext is such a hot idea because it is an enabling technology in that workstations and personal computers finally provide enough local processing power for hypertext user interfaces.

  11. Addressing endotoxin issues in bioengineered heparin.

    PubMed

    Suwan, Jiraporn; Torelli, Amanda; Onishi, Akihiro; Dordick, Jonathan S; Linhardt, Robert J

    2012-01-01

    Heparin is a widely used clinical anticoagulant that is prepared from pig intestine. A contamination of heparin in 2008 has led to a reexamination of animal-derived pharmaceuticals. A bioengineered heparin prepared by bacterial fermentation and chemical and enzymatic processing is currently under development. This study examines the challenges of reducing or removing endotoxins associated with this process that are necessary to proceed with preclinical in vivo evaluation of bioengineered heparin. The current process is assessed for endotoxin levels, and strategies are examined for endotoxin removal from polysaccharides and enzymes involved in this process. PMID:23586950

  12. Team Packs: Addressing Human Sexuality Issues.

    ERIC Educational Resources Information Center

    Florida Univ., Gainesville. Inst. for Child Health Policy.

    This kit provides materials that teach about Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS), sexually transmitted diseases (STDs), and pregnancy using group instructional methodology to actively engage students in the learning process. Using cooperative learning materials and videotape recordings, the program stresses…

  13. Excerpts from keynote address

    SciTech Connect

    Creel, G.C.

    1995-06-01

    Excerpts from the keynote principally address emissions issues in the fossil power industry as related to heat rate improvements. Stack emissions of both sulfur and nitrogen oxides are discussed, and a number of examples are given: (1) PEPCO`s Potomac River Station, and (2) Morgantown station`s NOX reduction efforts. Circulating water emissions are also briefly discussed, as are O & M costs of emission controls.

  14. Women's Issues Are Economic Issues.

    ERIC Educational Resources Information Center

    Schroeder, Patricia

    1983-01-01

    Faulty laws, unfair practices, and years of tradition in the workplace keep women from economic equality. The Economic Equity Act proposed by Congress will address inequalities in tax and retirement matters, the need for better dependent care, nondiscrimination in insurance, regulatory reform, and child support enforcement. (IS)

  15. 75 FR 41241 - Draft Regulatory Guide; Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... COMMISSION Draft Regulatory Guide; Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Issuance, availability of Draft Regulatory Guide (DG)-1234. ADDRESSES: You may submit comments by any one... and licenses. The draft regulatory guide, entitled, ``Water Sources for Long-Term...

  16. Bioreactors Addressing Diabetes Mellitus

    PubMed Central

    Minteer, Danielle M.; Gerlach, Jorg C.

    2014-01-01

    The concept of bioreactors in biochemical engineering is a well-established process; however, the idea of applying bioreactor technology to biomedical and tissue engineering issues is relatively novel and has been rapidly accepted as a culture model. Tissue engineers have developed and adapted various types of bioreactors in which to culture many different cell types and therapies addressing several diseases, including diabetes mellitus types 1 and 2. With a rising world of bioreactor development and an ever increasing diagnosis rate of diabetes, this review aims to highlight bioreactor history and emerging bioreactor technologies used for diabetes-related cell culture and therapies. PMID:25160666

  17. NRC regulatory agenda

    SciTech Connect

    Not Available

    1991-04-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has recently completed action or has proposed, or is considering action and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  18. NRC regulatory agenda

    SciTech Connect

    Not Available

    1992-05-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  19. NRC Regulatory Agenda

    SciTech Connect

    Not Available

    1991-10-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  20. NRC Regulatory Agenda

    SciTech Connect

    Not Available

    1991-08-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has recently completed action or has proposed, or is considering action and all petitions for rulemaking which have been received by the commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  1. NRC regulatory agenda

    SciTech Connect

    Not Available

    1993-04-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  2. NRC regulatory agenda

    SciTech Connect

    Not Available

    1990-07-01

    The NRC Regulatory Agenda is a compilation of all rules on which the NRC has proposed or is considering action and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  3. 75 FR 62893 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1196, ``Qualification for Cement... Commission (NRC) is issuing for public comment a draft guide in the agency's ``Regulatory Guide''...

  4. Overview and discussion of the key regulatory issues in implementing the electric utility provisions of the Clean Air Act Amendments of 1990

    SciTech Connect

    Rose, K.; Burns, R.E.

    1991-06-01

    Title 4 of the Clean Air Act Amendments of 1990 (CAAA) created a new regulatory instrument that electric power producers (utilities and others) will be required to possess and expand in order to emit sulfur dioxide (SO{sub 2}) into the atmosphere. The emission allowance system created by the CAAA will be grafted onto an already complex system of state and federal electric utility regulation. How public utility commissions (PUCs) and the Federal Energy Regulatory Commission (FERC) regulate these allowances will greatly affect the decisions that electric utilities under their jurisdiction make to comply with the CAAA and, therefore, the cost of compliance to ratepayers. 2 figs., 9 tabs.

  5. 10 CFR 218.34 - Addresses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Addresses. 218.34 Section 218.34 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Procedures § 218.34 Addresses. All..., Economic Regulatory Administration, Department of Energy, 2000 M Street, NW., Washington, DC 20461, and...

  6. Addressing Environmental Health Inequalities.

    PubMed

    Gouveia, Nelson

    2016-01-01

    Environmental health inequalities refer to health hazards disproportionately or unfairly distributed among the most vulnerable social groups, which are generally the most discriminated, poor populations and minorities affected by environmental risks. Although it has been known for a long time that health and disease are socially determined, only recently has this idea been incorporated into the conceptual and practical framework for the formulation of policies and strategies regarding health. In this Special Issue of the International Journal of Environmental Research and Public Health (IJERPH), "Addressing Environmental Health Inequalities-Proceedings from the ISEE Conference 2015", we incorporate nine papers that were presented at the 27th Conference of the International Society for Environmental Epidemiology (ISEE), held in Sao Paulo, Brazil, in 2015. This small collection of articles provides a brief overview of the different aspects of this topic. Addressing environmental health inequalities is important for the transformation of our reality and for changing the actual development model towards more just, democratic, and sustainable societies driven by another form of relationship between nature, economy, science, and politics. PMID:27618906

  7. Canadian drug regulatory framework.

    PubMed

    Kelly, L; Lazzaro, M; Petersen, C

    2007-03-01

    The role of regulatory drug submission evaluators in Canada is to critically assess both the data submitted and the sponsor's interpretation of the data in order to reach an evidence-, and context-based recommendation as to the potential benefits and potential harms (i.e., risks) associated with taking the drug under the proposed conditions of use. The purpose of this document is to outline the regulatory framework in which this assessment occurs, including: defining what "authorization to market a drug in Canada" means, in terms of the role of the sponsor, the responsibility of Health Canada in applying the Food and Drugs Act prior to and after marketing authorization, and the distinction between regulatory authorization versus physician authorization; highlighting organizational, process and legal factors within Health Canada related to authorization of clinical trials and authorization to market a drug; considerations during the review process, such as regulatory and scientific issues related to the drug, patient populations and trial designs; application of international guidelines, and decisions from other jurisdictions; regulatory realities regarding drug authorization, including the requirement for wording in the Product Monograph to accurately reflect the information currently available on the safe and effective use of a drug, and that hypothesis-confirming studies are essential to regulatory endorsement; current issues related to the review of therapies for dementia, such as assessing preventative treatments, and therapies that have symptomatic versus disease-modifying effects, statistical issues regarding missing data, and trial design issues. PMID:17469674

  8. Environment International, Special Issue, "Future Directions in Air Quality Research Ecological, Atmospheric, Regulatory/Policy/Economic, and Educational Issues", Volume 29, #2-3. June 2003. ISSN 0160 4120

    SciTech Connect

    Alcock, Ruth E; Heck, Walter W; Chappelka, Arthur H; Hunt, William F; Innes, John L; and Unsworth, Michael

    2003-06-01

    The Air Resources Consortium sponsored a Conference entitled "Future Directions in Air Quality Research". The Conference was held on February 12-15, 2001 at the Sheraton Imperial Hotel and Conference Center in the Research Triangle Park, NC. This was an international conference that had wide interest in both the scientific and regulatory communities at both State and Federal levels in the U.S. and in the international community. Attendance over the four days of the Conference was over 200 with excellent international participation. The primary purpose of the Conference was to highlight future directions in air quality research based on our current knowledge and ongoing research. Three atmospheric contaminates (ozone, carbon dioxide and species of nitrogen) as the primary focus for the Conference, since they would likely be of continuing concern to the international community over the next several decades. Speakers focused on ways that research could support regulatory, policy and environmental needs of federal, state and local government as well as the concerns of both industrial and environmental groups. Economic impacts were considered when covering policy implications. The program was developed around ecological effects, atmospheric processes and their relationships. Conference speakers were asked to develop their papers for inclusion in a Conference Proceedings. The proceedings were published in the Journal "Environment International" as Volume 29, Numbers 2-3, in June of 2003. Copies of the Proceedings have been sent to DOE.

  9. Regulatory oversight in the United States of vascularized composite allografts.

    PubMed

    Glazier, Alexandra K

    2016-06-01

    Vascularized composite allograft (VCA) transplantation is a medically acceptable treatment for the reconstruction of major tissue loss. The advent of VCA transplantation has spurred regulatory and policy development in the United States to address the multiple clinical, ethical and legal issues that must be considered for the practice of VCA donation and transplantation to develop within the existing framework of public trust and transparency vital to the success of donation and transplantation. PMID:26284312

  10. Regulatory instrument review: Aging management of LWR cables, containment and basemat, reactor coolant pumps, and motor-operated valves

    SciTech Connect

    Werry, E.V.; Somasundaram, S.

    1995-09-01

    The results of Stage 2 of the Regulatory Instrument Review are presented in this volume. Selected regulatory instruments, such as the Code of Federal Regulations (CFR), US Nuclear Regulatory Commission (NRC), Regulatory Guides, and ASME Codes, were investigated to determine the extent to which these regulations apply aging management to selected safety-related components in nuclear power plants. The Regulatory Instrument Review was funded by the NRC under the Nuclear Plant Aging Research (NPAR) program. Stage 2 of the review focused on four safety-related structures and components; namely, cables, containment and basemat, reactor coolant pumps, and motor-operated valves. The review suggests that the primary-emphasis of the regulatory instruments was on the design, construction, start-up, and operation of a nuclear power plant, and that aging issues were primarily addressed after an aging-related problem was recognized. This Stage 2 review confirms the results of the prior review; (see Regulatory Instrument Review: Management of Aging of LWR Major Safety-Related Components NUREG/CR-5490. The observations indicate that the regulations generally address management of age-related degradation indirectly. Specific age-related degradation phenomena frequently are dealt with in bulletins and notices or through generic issues, letters, etc. The major recommendation of this report, therefore, is that the regulatory instruments should more directly and explicitly address the aging phenomenon and the management of the age-related degradation process.

  11. Regulatory aspects of clinical xenotransplantation.

    PubMed

    Schuurman, Henk-Jan

    2015-11-01

    Xenotransplantation attracted interest from regulatory authorities, particularly after the demonstration of pig-to-human transmission of porcine endogenous retrovirus (1996). This added to the risk of a product, resulting in a Guidance of the US Food and Drug Administration (2003). This addresses the full flow chart in product manufacturing, starting with the designated pathogen-free status of the source animal; and special aspects regarding the recipient like informed consent and monitoring for infectious pathogens. Also archiving of records from the donor and recipient, as well as storage of samples is described. The European Medicines Agency issued a Guideline on xenogeneic cell therapy products (2009). Cell-based medicinal products are subject to specific regulations and directives, which apply also to xenogeneic products: the xenotransplant guidances/guidelines are an addition to these regulations. Noteworthy, acellular products like heart valves and decellularized cornea are not considered a cell therapy product, but rather a medical device with its own regulation. WHO issued relevant documents, especially about safety, and the International Xenotransplantation Association published consensus documents, a.o., addressing preclinical efficacy requirements before entering clinical trials. This manuscript presents an overview of the regulatory framework, with special focus on cell therapy products necause these are expected to reach the market first (i.e., pancreatic islets, hepatocytes and cellularized cornea); major illustrations are from the European situation. Albeit being complex, the regulation of xenotransplant products does not form a block in product development, but rather supports the introduction of efficacious and safe products to meet the medical need. PMID:26408947

  12. Awards and Addresses Summary

    PubMed Central

    2008-01-01

    Each year at the annual ASHG meeting, addresses are given in honor of the society and a number of award winners. A summary of each of these addresses is given below. On the next pages, we have printed the Presidential Address and the addresses for the William Allan Award. The other addresses, accompanied by pictures of the speakers, can be found at www.ashg.org.

  13. Issues in Peer Review.

    ERIC Educational Resources Information Center

    Sawamura, Mark H.

    2001-01-01

    Based on concerns raised at a workshop at the Southern California College of Optometry, addresses critical issues in the process of peer review of faculty teaching and possible alternatives to these issues as applied to an optometric institution. (EV)

  14. Regulatory guidance document

    SciTech Connect

    1994-05-01

    The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

  15. Public participation in environmental issues

    SciTech Connect

    Pilot, J.

    1998-12-31

    The need for public participation in environmental issues has grown in the past five years. The Responsible Care{reg_sign} Program, developed by the chemical industry, as well as government requirements for citizens` input into regulatory review have initiated public committees for environmental management issues. This paper will discuss three programs that have been implemented in Ontario to assist in public participation in environmental issues covering the following: 1. Great Waste Management Debate held in co-operation with Government, Boards of Trade, Industry, and Youth; 2. Public Liaison committee for Ontario`s Resource Recovery -- Waste to Energy Facility operating in the Region of Peel, the role they have played in its operation with the community; and 3. Brampton Environmental Community Advisory Panel, initiated by the Brampton Chemical Association`s need under Responsible Care for a public program to address concern related to company`s environmental issues in the community. As Chair of all three Committees, the paper will cover the benefits of the committees for public input and review of environmental issues related to environmental management.

  16. Social Security and Undergraduates with Disabilities: An Analysis of the National Postsecondary Student Aid Survey. Addressing Trends in Development in Secondary Education and Transition. Information Brief. Vol. 3, Issue 4.

    ERIC Educational Resources Information Center

    Berry, Hugh; Conway, Megan A.; Change, Kelly B.T.

    2004-01-01

    The purpose of this brief is to describe the characteristics of undergraduate students receiving Social Security Disability Insurance (SSDI) and Social Security Administration (SSI) benefits as they relate to issues of participation in postsecondary education and employment. This brief describes results from the National Postsecondary Student Aid…

  17. Regulatory analysis for the resolution of Generic Safety Issue 105: Interfacing system loss-of-coolant accident in light-water reactors

    SciTech Connect

    Not Available

    1993-07-01

    An interfacing systems loss of coolant accident (ISLOCA) involves failure or improper operation of pressure isolation valves (PIVs) that compose the boundary between the reactor coolant system and low-pressure rated systems. Some ISLOCAs can bypass containment and result in direct release of fission products to the environment. A cost/benefit evaluation, using three PWR analyses, calculated the benefit of two potential modifications to the plants. Alternative 1 is improved plant operations to optimize the operator`s performance and reduce human error probabilities. Alternative 2 adds pressure sensing devices, cabling, and instrumentation between two PIVs to provide operators with continuous monitoring of the first PIV. These two alternatives were evaluated for the base case plants (Case 1) and for each plant, assuming the plants had a particular auxiliary building design in which severe flooding would be a problem if an ISLOCA occurred. The auxiliary building design (Case 2) was selected from a survey that revealed a number of designs with features that provided less than optimal resistance to ECCS equipment loss caused by a ISLOCA-induced environment. The results were judged not to provide sufficient basis for generic requirements. It was concluded that the most viable course of action to resolve Generic Issue 105 is licensee participation in individual plant examinations (IPEs).

  18. Status of safety issues at licensed power plants: TMI Action Plan requirements; unresolved safety issues; generic safety issues; other multiplant action issues. Supplement 3

    SciTech Connect

    Not Available

    1993-12-01

    As part of ongoing US Nuclear Regulatory Commission (NRC) efforts to ensure the quality and accountability of safety issue information, the NRC established a program for publishing an annual report on the status of licensee implementation and NRC verification of safety issues in major NRC requirements areas. This information was initially compiled and reported in three NUREG-series volumes. Volume 1, published in March 1991, addressed the status of Three Mile Island (TMI) Action Plan Requirements. Volume 2, published in May 1991, addressed the status of unresolved safety issues (USIs). Volume 3, published in June 1991, addressed the implementation and verification status of generic safety issues (GSIs). The first annual supplement, which combined these volumes into a single report and presented updated information as of September 30, 1991, was published in December 1991. The second annual supplement, which provided updated information as of September 30, 1992, was published in December 1992. Supplement 2 also provided the status of licensee implementation and NRC verification of other multiplant action (MPA) issues not related to TMI Action Plan requirements, USIs, or GSIs. This third annual NUREG report, Supplement 3, presents updated information as of September 30, 1993. This report gives a comprehensive description of the implementation and verification status of TMI Action Plan requirements, safety issues designated as USIs, GSIs, and other MPAs that have been resolved and involve implementation of an action or actions by licensees. This report makes the information available to other interested parties, including the public. Additionally, this report serves as a follow-on to NUREG-0933, ``A Prioritization of Generic Safety Issues,`` which tracks safety issues until requirements are approved for imposition at licensed plants or until the NRC issues a request for action by licensees.

  19. Steam generator issues in the United States

    SciTech Connect

    Strosnider, J.R.

    1997-02-01

    Alloy 600 steam generator tubes in the US have exhibited degradation mechanisms similar to those observed in other countries. Effective programs have been implemented to address several degradation mechanisms including: wastage; mechanical wear; pitting; and fatigue. These degradation mechanisms are fairly well understood as indicated by the ability to effectively mitigate/manage them. Stress corrosion cracking (SCC) is the dominant degradation mechanism in the US. SCC poses significant inspection and management challenges to the industry and the regulators. The paper also addresses issues of research into SCC, inspection programs, plugging, repair strategies, water chemistry, and regulatory control. Emerging issues in the US include: parent tube cracking at sleeve joints; detection and repair of circumferential cracks; free span cracking; inspection and cracking of dented regions; and severe accident analysis.

  20. NRC regulatory agenda

    SciTech Connect

    Not Available

    1993-02-01

    This document is a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considered action, and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  1. NRC regulatory agenda

    SciTech Connect

    Not Available

    1992-11-01

    This document provides a compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rulemaking which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  2. NRC Regulatory Agenda

    SciTech Connect

    Not Available

    1992-07-01

    This document compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and all petitions for rule making which have been received by the Commission and are pending disposition by the Commission. The Regulatory Agenda is updated and issued each quarter.

  3. Addressing Your Child's Weight at the Doctor

    MedlinePlus

    ... a Healthy Heart Healthy Kids Our Kids Programs Childhood Obesity What is childhood obesity? Overweight in Children BMI in Children Is Childhood Obesity an Issue in Your Home? Addressing your Child's ...

  4. Hazardous waste: 1998 Regulatory and judicial developments

    SciTech Connect

    Henry, M.E.; Wright, W.G. Jr.

    1998-12-31

    Every year, owners and operators of facilities generating, transporting, treating, storing, or disposing of hazardous waste, or persons held liable for past hazardous waste management practice through EPA`s Superfund program, are affected by changes in the application and interpretation of hazardous waste regulation. This paper will summarize the significant 1997 hazardous waste regulatory developments, including changes and additions to land disposal restrictions and treatment standards, hazardous waste determination procedures, used oil management practices. This paper will also summarize key judicial decisions addressing expanded definitions of solid and hazardous waste, activities constituting disposal, and circumstances constituting imminent and substantial endangerment. Finally, this paper will summarize new EPA Superfund guidance documents and judicial decisions addressing issues of liability and defenses to liability under Superfund.

  5. Economic analysis requirements in support of orbital debris regulatory policy

    NASA Astrophysics Data System (ADS)

    Greenberg, Joel S.

    1996-10-01

    As the number of Earth orbiting objects increases so does the potential for generating orbital debris with the consequent increase in the likelihood of impacting and damaging operating satellites. Various debris remediation approaches are being considered that encompass both in-orbit and return-to-Earth schema and have varying degrees of operations, cost, international competitiveness, and safety implications. Because of the diversity of issues, concerns and long-term impacts, there is a clear need for the setting of government policies that will lead to an orderly abatement of the potential orbital debris hazards. These policies may require the establishment of a supportive regulatory regime. The Department of Transportation is likely to have regulatory responsibilities relating to orbital debris stemming from its charge to protect the public health and safety, safety of property, and national security interests and foreign policy interests of the United States. This paper describes DOT's potential regulatory role relating to orbital debris remediation, the myriad of issues concerning the need for establishing government policies relating to orbital debris remediation and their regulatory implications, the proposed technological solutions and their economic and safety implications. Particular emphasis is placed upon addressing cost-effectiveness and economic analyses as they relate to economic impact analysis in support of regulatory impact analysis.

  6. 75 FR 20645 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-20

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-4018. FOR FURTHER INFORMATION CONTACT... Regulatory Commission (NRC) is issuing for public comment a draft guide in the agency's ``Regulatory...

  7. 76 FR 6086 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... COMMISSION 10 CFR Part 73 RIN 3150-AI49 Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Availability of Draft Regulatory Guide. SUMMARY: The U.S. Nuclear Regulatory Commission (Commission or NRC) is issuing for public comment Draft Regulatory Guide,...

  8. 75 FR 36715 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide, RG 1.62. FOR FURTHER INFORMATION CONTACT: Karl J... Regulatory Commission (NRC or Commission) is issuing a revision of a guide in the agency's ``Regulatory...

  9. 76 FR 27924 - Draft Regulatory Guide, Guidance for ITAAC Closure

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... COMMISSION 10 CFR Parts 2 and 52 RIN 3150-AI77 Draft Regulatory Guide, Guidance for ITAAC Closure AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment Draft Regulatory Guide...

  10. Is It More Important to Address the Issue of Patient Mobility or to Guarantee Universal Health Coverage in Europe?: Comment on "Regional Incentives and Patient Cross-Border Mobility: Evidence From the Italian Experience".

    PubMed

    Legido-Quigley, Helena

    2016-01-01

    This paper discusses whether European institutions should devote so much attention and funding to cross-border healthcare or they should instead prioritise guaranteeing universal health coverage (UHC), "addressing inequalities" and tackling the effects of austerity measures. The paper argues through providing the evidence in both areas of research, that the priority at European level from a public health and social justice perspective should be to guarantee UHC for all the population living in Europe and prioritise protective action for those who are most in need. PMID:26673649

  11. Combustion engineering issues for solid fuel systems

    SciTech Connect

    Bruce Miller; David Tillman

    2008-05-15

    The book combines modeling, policy/regulation and fuel properties with cutting edge breakthroughs in solid fuel combustion for electricity generation and industrial applications. This book provides real-life experiences and tips for addressing the various technical, operational and regulatory issues that are associated with the use of fuels. Contents are: Introduction; Coal Characteristics; Characteristics of Alternative Fuels; Characteristics and Behavior of Inorganic Constituents; Fuel Blending for Combustion Management; Fuel Preparation; Conventional Firing Systems; Fluidized-Bed Firing Systems; Post-Combustion Emissions Control; Some Computer Applications for Combustion Engineering with Solid Fuels; Gasification; Policy Considerations for Combustion Engineering.

  12. Mediating equity in shared water between community and industry: The effects of an after school program that addresses adolescents' knowledge, attitudes, and perceptions of water science and environmental issues

    NASA Astrophysics Data System (ADS)

    Patton, Mary Chandler

    This critical ethnography deconstructs how one participant researcher came to understand young adults' changing knowledge about water science and environmental issues in an after school program in Colombia. The program intended to empower self-identified young community leaders by teaching participants to engage community members in discourse related to how environmental factors impact one's level of health and quality of life. The data presented in this study illustrate how student participants responded to long-term teacher engagement and to particular curricular components that included hands-on science teaching and social justice coaching. I assessed how student interest in and knowledge of local water ecology and sanitation infrastructure changed throughout the program. Students' responses to the use of technology and digital media were also included in the analysis. The data demonstrates a dramatic change in student's attitudes and perceptions related to their environment and how they feel about their ability to make positive changes in their community.

  13. 75 FR 61531 - Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... COMMISSION Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice. SUMMARY: The... Guide 1.193, Rev. 3, ``ASME Code Cases Not Approved for Use.'' FOR FURTHER INFORMATION CONTACT: Wallace... Wallace.Norris@nrc.gov . SUPPLEMENTARY INFORMATION: I. Introduction The NRC is issuing Regulatory...

  14. Contemporary Native American Address.

    ERIC Educational Resources Information Center

    Maestas, John R., Ed.

    A compilation of 58 representative speeches from the American Indian Community, this book is divided into 2 parts; Part I deals with issues of contemporary concern and Part II illustrates speech types and styles. All speeches are classified by issue as follows: sovereignty (2 speeches, 1 on the rise and fall of Indian sovereignty); trust…

  15. Opioid prescribing pitfalls: medicolegal and regulatory issues

    PubMed Central

    Jammal, Walid; Gown, Grace

    2015-01-01

    Summary Inappropriate opioid prescribing can lead to patient harm as well as a medicolegal risk to prescribers. Prescribers need to be familiar with the indications, contraindications and harms associated with opioids. When prescribing opioids, doctors must be aware of their clinical, ethical and legal responsibilities, particularly the legislative requirements in their state. Failure to comply with these can result in disciplinary action. To avoid potential conflict with differing state regulations on opioid prescribing, doctors should advise patients to get their prescription dispensed in the same state in which it was written. PMID:26843712

  16. Chemical warfare materiel: Unique regulatory issues

    SciTech Connect

    Etnier, E.L.; King, J.F.; Watson, A.P.

    2000-04-01

    The US Army manages an extensive program of environmental restoration that is carried out primarily under authority of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), which establishes response authority for cleanup of inactive waste sites. The Resource Conservation and Recovery Act (RCRA) regulates the management and cleanup of hazardous materials at active hazardous wastes facilities. Based on the definition found in these acts, and corresponding promulgated regulations, environmental media contaminated with chemical warfare material (CWM) can be regulated as CERCLA pollutants for contaminants but do not appear to be regulated either as CERCLA hazardous substances or RCRA hazardous wastes. in those states that have not included CWM as hazardous materials in their RCRA programs, the RCRA requirements for management of hazardous waste would not strictly apply to any of the CWM. The Army has historically implemented procedures requiring that chemical warfare agents be managed as RCRA hazardous waste regardless of the concentration, physical form, or configuration of the agent. Such application of strict hazardous waste requirements to management of potentially nonhazardous CWM can result in remedial costs well out of proportion to potential human health and environmental benefits. Recent development of chronic toxicity values for the CWM has opened the door for development of cleanup and waste management standards for waste streams or media containing small residual amounts of CWM. Implementation of this health-based approach to management of CWM remediation wastes may, in part, help to reduce potentially unnecessary hazardous waste management costs for the nonhazardous CWM.

  17. PROFILE: Chemical Warfare Materiel: Unique Regulatory Issues.

    PubMed

    Etnier; King; Watson

    2000-04-01

    / The US Army manages an extensive program of environmental restoration that is carried out primarily under authority of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), which establishes response authority for cleanup of inactive waste sites. The Resource Conservation and Recovery Act (RCRA) regulates the management and cleanup of hazardous materials at active hazardous waste facilities. Based on the definitions found in these acts, and corresponding promulgated regulations, environmental media contaminated with chemical warfare materiel (CWM) can be regulated as CERCLA "pollutants or contaminants" but do not appear to be regulated either as CERCLA hazardous substances or RCRA hazardous wastes.In those states that have not included CWM as hazardous materials in their RCRA programs, the RCRA requirements for management of hazardous waste would not strictly apply to any of the CWM. The Army has historically implemented procedures requiring that chemical warfare agents be managed as RCRA hazardous waste regardless of the concentration, physical form, or configuration of the agent. Such application of strict hazardous waste requirements to management of potentially nonhazardous CWM can result in remedial costs well out of proportion to potential human health and environmental benefits. Recent development of chronic toxicity values for the CWM has opened the door for development of cleanup and waste management standards for waste streams or media containing small residual amounts of CWM. Implementation of this health-based approach to management of CWM remediation wastes may, in part, help to reduce potentially unnecessary hazardous waste management costs for the nonhazardous CWM. PMID:10667941

  18. Regulatory views on current criticality safety issues

    SciTech Connect

    Conde, J.M.; Recio, M.

    1996-12-31

    The nuclear facilities in Spain of interest from the stand-point of criticality are a fuel fabrication facility, handling only fresh fuel; seven pressurized water reactor (PWR) plants with different nuclear steam supply system designs; two boiling water reactor (BWR) plants; and an ongoing program of dual-purpose casks (storage and transport) for spent fuel. Given the spent-fuel storage space problems with the original rack designs, a plan was developed and started in 1990 to incorporate high-density racks (borated steel or Boral) in the spent-fuel storage of all plants, giving credit for fuel burnup. Following this plan, five PWR units have licensed burnup-credited criticality safety analyses using a two-zone approach (fresh and spent fuel) for the spent-fuel pool. The two BWR plants have also licensed a criticality safety analysis with credit for the reactivity reduction provided by the gadolinia rods. The only spent-fuel cask yet licensed has followed the expected fresh fuel assumption for the criticality safety evaluation. However, it can be expected that the industry will submit burnup-credit safety analyses for the future casks designs.

  19. Addressivity in cogenerative dialogues

    NASA Astrophysics Data System (ADS)

    Hsu, Pei-Ling

    2014-03-01

    Ashraf Shady's paper provides a first-hand reflection on how a foreign teacher used cogens as culturally adaptive pedagogy to address cultural misalignments with students. In this paper, Shady drew on several cogen sessions to showcase his journey of using different forms of cogens with his students. To improve the quality of cogens, one strategy he used was to adjust the number of participants in cogens. As a result, some cogens worked and others did not. During the course of reading his paper, I was impressed by his creative and flexible use of cogens and at the same time was intrigued by the question of why some cogens work and not others. In searching for an answer, I found that Mikhail Bakhtin's dialogism, especially the concept of addressivity, provides a comprehensive framework to address this question. In this commentary, I reanalyze the cogen episodes described in Shady's paper in the light of dialogism. My analysis suggests that addressivity plays an important role in mediating the success of cogens. Cogens with high addressivity function as internally persuasive discourse that allows diverse consciousnesses to coexist and so likely affords productive dialogues. The implications of addressivity in teaching and learning are further discussed.

  20. Regulatory Compliance in Multi-Tier Supplier Networks

    NASA Technical Reports Server (NTRS)

    Goossen, Emray R.; Buster, Duke A.

    2014-01-01

    Over the years, avionics systems have increased in complexity to the point where 1st tier suppliers to an aircraft OEM find it financially beneficial to outsource designs of subsystems to 2nd tier and at times to 3rd tier suppliers. Combined with challenging schedule and budgetary pressures, the environment in which safety-critical systems are being developed introduces new hurdles for regulatory agencies and industry. This new environment of both complex systems and tiered development has raised concerns in the ability of the designers to ensure safety considerations are fully addressed throughout the tier levels. This has also raised questions about the sufficiency of current regulatory guidance to ensure: proper flow down of safety awareness, avionics application understanding at the lower tiers, OEM and 1st tier oversight practices, and capabilities of lower tier suppliers. Therefore, NASA established a research project to address Regulatory Compliance in a Multi-tier Supplier Network. This research was divided into three major study efforts: 1. Describe Modern Multi-tier Avionics Development 2. Identify Current Issues in Achieving Safety and Regulatory Compliance 3. Short-term/Long-term Recommendations Toward Higher Assurance Confidence This report presents our findings of the risks, weaknesses, and our recommendations. It also includes a collection of industry-identified risks, an assessment of guideline weaknesses related to multi-tier development of complex avionics systems, and a postulation of potential modifications to guidelines to close the identified risks and weaknesses.

  1. The core to regulatory reform

    SciTech Connect

    Partridge, J.W. Jr.

    1993-06-15

    Federal Energy Regulatory Commission (FERC) Orders 436, 500, and 636, the Clean Air Act Amendments of 1990, Public Utility Holding Company Act reform, and the 1992 Energy Policy Act all can have significant effects on an LDC's operations. Such changes in an LDC's environments must be balanced by changes within the utility, its marketplace, and its state regulatory environment. The question is where to start. For Columbia Gas Distribution Cos., based in Columbus, OH, the new operating foundation begins with each employee. Internal strength is critical in designing initiatives that meet the needs of the marketplace and are well-received by regulators. Employees must understand not only the regulatory environment in which the LDC operates, but also how their work contributes to a positive regulatory relationship. To achieve this, Columbia initiated the COntinuing Regulatory Education program, or CORE, in 1991. CORE is a regulatory-focused, information-initiative program coordinated by Columbia's Regulatory Policy, Planning, and Government Affairs Department. The CORE programs can take many forms, such as emerging issue discussions, dialogues with regulators and key parties, updates on regulatory fillings, regulatory policy meetings, and formal training classes. The speakers and discussion facilitators can range from human resource department trainers to senior officers, from regulatory department staff members to external experts, or from state commissioners to executives from other LDCs. The goals of CORE initiatives are to: Support a professional level of regulatory expertise through employee participation in well-developed regulatory programs presented by credible experts. Encourage a constructive state regulatory environment founded on communication and cooperation. CORE achieves these goals via five program levels: introductory basics, advanced learning, professional expertise, crossfunctional dialogues, and external idea exchanges.

  2. The U.S. Nuclear Regulatory Commission's Strategy for Revising the RIA Acceptance Criteria

    SciTech Connect

    Clifford, Paul M.

    2007-07-01

    The U.S. Nuclear Regulatory Commission (NRC) has issued interim criteria and guidance for the reactivity-initiated accident (RIA) within the latest revision to NUREG-0800, 'Standard Review Plan' (SRP), Section 4.2, 'Fuel System Design', Appendix B (Revision 03, March 2007). The purpose of this paper is as follows: 1. present a change in regulatory staff position regarding the requirements of 10 CFR 50, Appendix A, General Design Criteria 28 (GDC28) and changes in regulatory guidance provided in Regulatory Guide (RG) 1.77, RG 1.195, RG 1.183, and previous versions of NUREG-0800 SRP; 2. describe the implementation strategy and schedule for both new reactors and the existing fleet; and 3. encourage licensees and nuclear fuel vendors to (1) develop improved core physics analytical methods to allow a more deliberate transition to the new fuel cladding failure criteria and (2) develop the technical basis to address the new core coolability criteria. (authors)

  3. States Address Achievement Gaps.

    ERIC Educational Resources Information Center

    Christie, Kathy

    2002-01-01

    Summarizes 2 state initiatives to address the achievement gap: North Carolina's report by the Advisory Commission on Raising Achievement and Closing Gaps, containing an 11-point strategy, and Kentucky's legislation putting in place 10 specific processes. The North Carolina report is available at www.dpi.state.nc.us.closingthegap; Kentucky's…

  4. Address of the President

    ERIC Educational Resources Information Center

    Ness, Frederic W.

    1976-01-01

    The president of the Association of American Colleges addresses at the 62nd annual meeting the theme of the conference: "Looking to the Future--Liberal Education in a Radically Changing Society." Contributions to be made by AAC are examined. (LBH)

  5. Addressing Sexual Harassment

    ERIC Educational Resources Information Center

    Young, Ellie L.; Ashbaker, Betty Y.

    2008-01-01

    This article discusses ways on how to address the problem of sexual harassment in schools. Sexual harassment--simply defined as any unwanted and unwelcome sexual behavior--is a sensitive topic. Merely providing students, parents, and staff members with information about the school's sexual harassment policy is insufficient; schools must take…

  6. Space sciences - Keynote address

    NASA Technical Reports Server (NTRS)

    Alexander, Joseph K.

    1990-01-01

    The present status and projected future developments of the NASA Space Science and Applications Program are addressed. Emphasis is given to biochemistry experiments that are planned for the Space Station. Projects for the late 1990s which will study the sun, the earth's magnetosphere, and the geosphere are briefly discussed.

  7. The regulatory sciences for stem cell-based medicinal products.

    PubMed

    Yuan, Bao-Zhu; Wang, Junzhi

    2014-06-01

    Over the past few years, several new achievements have been made from stem cell studies, many of which have moved up from preclinical stages to early, or from early to middle or late, stages thanks to relatively safe profile and preliminary evidence of effectiveness. Moreover, some stem cell-based products have been approved for marketing by different national regulatory authorities. However, many critical issues associated mainly with incomplete understanding of stem cell biology and the relevant risk factors, and lack of effective regulations still exist and need to be urgently addressed, especially in countries where establishment of appropriate regulatory system just commenced. More relevantly, the stem cell regulatory sciences need to be established or improved to more effectively evaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatory framework. In this review, we summarize some new achievements in stem cell studies, especially the preclinical and clinical studies, the existing regulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem cell therapies abreast of evolvement of stem cell sciences and technologies. PMID:24733351

  8. Space Station Software Issues

    NASA Technical Reports Server (NTRS)

    Voigt, S. (Editor); Beskenis, S. (Editor)

    1985-01-01

    Issues in the development of software for the Space Station are discussed. Software acquisition and management, software development environment, standards, information system support for software developers, and a future software advisory board are addressed.

  9. Natural gas 1995: Issues and trends

    SciTech Connect

    1995-11-01

    Natural Gas 1995: Issues and Trends addresses current issues affecting the natural gas industry and markets. Highlights of recent trends include: Natural gas wellhead prices generally declined throughout 1994 and for 1995 averages 22% below the year-earlier level; Seasonal patterns of natural gas production and wellhead prices have been significantly reduced during the past three year; Natural gas production rose 15% from 1985 through 1994, reaching 18.8 trillion cubic feet; Increasing amounts of natural gas have been imported; Since 1985, lower costs of producing and transporting natural gas have benefitted consumers; Consumers may see additional benefits as States examine regulatory changes aimed at increasing efficiency; and, The electric industry is being restructured in a fashion similar to the recent restructuring of the natural gas industry.

  10. 21 CFR 1321.01 - DEA mailing addresses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false DEA mailing addresses. 1321.01 Section 1321.01 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE DEA MAILING ADDRESSES § 1321.01... substances certification request. DEA Regulatory Section 1301.71(d)—Security system compliance review...

  11. 10 CFR 590.104 - Address for filing documents.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Address for filing documents. 590.104 Section 590.104 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.104 Address...

  12. 10 CFR 590.104 - Address for filing documents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Address for filing documents. 590.104 Section 590.104 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.104 Address...

  13. 10 CFR 590.104 - Address for filing documents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Address for filing documents. 590.104 Section 590.104 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.104 Address...

  14. 10 CFR 590.104 - Address for filing documents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Address for filing documents. 590.104 Section 590.104 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.104 Address...

  15. 10 CFR 590.104 - Address for filing documents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Address for filing documents. 590.104 Section 590.104 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.104 Address...

  16. 48 CFR 401.170 - Electronic access to regulatory information.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... regulatory information. 401.170 Section 401.170 Federal Acquisition Regulations System DEPARTMENT OF... access to regulatory information. The USDA Departmental Administration Procurement Homepage provides... guidance in electronic form. The Internet address for the Procurement Homepage is URL...

  17. Holographic content addressable storage

    NASA Astrophysics Data System (ADS)

    Chao, Tien-Hsin; Lu, Thomas; Reyes, George

    2015-03-01

    We have developed a Holographic Content Addressable Storage (HCAS) architecture. The HCAS systems consists of a DMD (Digital Micromirror Array) as the input Spatial Light Modulator (SLM), a CMOS (Complementary Metal-oxide Semiconductor) sensor as the output photodetector and a photorefractive crystal as the recording media. The HCAS system is capable of performing optical correlation of an input image/feature against massive reference data set stored in the holographic memory. Detailed system analysis will be reported in this paper.

  18. 76 FR 18262 - Notice of issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... COMMISSION Notice of issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.44, Revision 1, ``Control of the Processing and Use of... Commission (NRC) is issuing a revision to an existing guide in the agency's ``Regulatory Guide'' series....

  19. 75 FR 27599 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide 6.7, Revision 2, ``Preparation of an Environmental Report To... The U.S. Nuclear Regulatory Commission (NRC) is issuing a revision to an existing guide in the...

  20. 75 FR 62436 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide 1.54, Revision 2, ``Service Level I, II, and III Protective.... Introduction The U.S. Nuclear Regulatory Commission (NRC) is issuing a revision to an existing guide in...

  1. 75 FR 42170 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Regulatory Guide, RG 8.40, ``Methods for Measuring Effective Dose... . SUPPLEMENTARY INFORMATION: I. Introduction The U.S. Nuclear Regulatory Commission (NRC) is issuing a new...

  2. 76 FR 38213 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Revision 2 of Regulatory Guide 1.107, ``Qualification for Cement Grouting for... or Commission) is issuing a revision to an existing guide in the agency's ``Regulatory Guide''...

  3. 76 FR 28102 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... COMMISSION Notice of Issuance of Regulatory Guide AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide 1.177, Revision 1, ``An Approach for Plant-Specific, Risk... issuing a revision to an existing guide in the agency's ``Regulatory Guide'' series. This series...

  4. Nuclear Regulatory Commission Issuances, Volume 42, No. 2

    SciTech Connect

    1995-08-01

    This report include the issuances received during the specificed period (August 1995) from the NRC, the Atomic Safety and Licensing Boards, the Administrative Law Judges, and the Decisions on Petitions for Rule Making. In these issuances, the following areas were addressed: (1) Emergency planning at the University of Missouri, (2) Transfer of operating license at Plant Vogtle, (3) Discriminatory action against a whistle-blower at Millstone Units 1 & 2, (4) Regulatory issues related to embittlement and cracking at Oyster Creek, and (5) Age-related deterioration of reactor internals components at Pilgrim.

  5. Addressing viral resistance through vaccines

    PubMed Central

    Laughlin, Catherine; Schleif, Amanda; Heilman, Carole A

    2015-01-01

    Antimicrobial resistance is a serious healthcare concern affecting millions of people around the world. Antiviral resistance has been viewed as a lesser threat than antibiotic resistance, but it is important to consider approaches to address this growing issue. While vaccination is a logical strategy, and has been shown to be successful many times over, next generation viral vaccines with a specific goal of curbing antiviral resistance will need to clear several hurdles including vaccine design, evaluation and implementation. This article suggests that a new model of vaccination may need to be considered: rather than focusing on public health, this model would primarily target sectors of the population who are at high risk for complications from certain infections. PMID:26604979

  6. New smart materials to address issues of structural health monitoring.

    SciTech Connect

    Chaplya, Pavel Mikhail

    2004-12-01

    Nuclear weapons and their storage facilities may benefit from in-situ structural health monitoring systems. Appending health-monitoring functionality to conventional materials and structures has been only marginally successful. The purpose of this project was to evaluate feasibility of a new smart material that includes self-sensing health monitoring functions similar to that of a nervous system of a living organism. Reviews of current efforts in the fields of heath-monitoring, nanotechnology, micro-electromechanical systems (MEMS), and wireless sensor networks were conducted. Limitations of the current nanotechnology methods were identified and new approaches were proposed to accelerate the development of self-sensing materials. Wireless networks of MEMS sensors have been researched as possible prototypes of self-sensing materials. Sensor networks were also examined as enabling technologies for dense data collection techniques to be used for validation of numerical methods and material parameter identification. Each grain of the envisioned material contains sensors that are connected in a dendritic manner similar to networks of neurons in a nervous system. Each sensor/neuron can communicate with the neighboring grains. Both the state of the sensor (on/off) and the quality of communication signal (speed/amplitude) should indicate not only a presence of a structural defect but the nature of the defect as well. For example, a failed sensor may represent a through-grain crack, while a lost or degraded communication link may represent an inter-granular crack. A technology to create such material does not exist. While recent progress in the fields of MEMS and nanotechnology allows to envision these new smart materials, it is unrealistic to expect creation of self-sensing materials in the near future. The current state of MEMS, nanotechnology, communication, sensor networks, and data processing technologies indicates that it will take more than ten years for the technologies to mature enough to make self-sensing materials a reality. Nevertheless, recent advances in the field of nanotechnology demonstrate that nanotubes, nanorods, and nanoparticles of carbon, boron and other materials have remarkable mechanical and electrical properties. This would provide. for a plethora of potential applications including self-sensing materials. Record strength-to-weight ratios, ballistic conductivity, and sensing capabilities (i.e., piezo- resistance and piezoelectricity) have been reported for carbon nanotubes. The first transistors, sensors, and actuators have been made from the carbon nanotubes and other nanomaterials. However, nanomaterials are notoriously difficult to manipulate into useful geometries. Nano-manufacturing processes often produce bundles or random networks of nanostructured materials. Samples of the material are then manipulated with advanced microscopy tools to measure properties or to create a single device. This is a laborious and time consuming process. An often overlooked property of the manufactured nanotube bundles is their similarity to the dendritic structure of neural networks with a great quantity of interconnects that may serve as initiation sites for artificial neurons in a self-sensing material nervous system. To accelerate the development of self-sensing materials, future research should concentrate on naturally occurring dendritic nano-structures. While self-sensing materials with subgrain size sensors (scale of micrometers) remain in the realm of basic research, meso-scale (millimeters to centimeters) sensors and their networks are in the state of mature research and have begun to find their way into commercial applications. Macro-scale (centimeters to decimeters) sensors and their networks are commercially available from various sources. The majority of applications that employ sensor networks are driven by the needs of the Department of Defense. Widespread adaptation of sensor networks has been limited by, on one hand, the sensor's high cost of design, development, and deployment, and on the other hand,

  7. Addressing Poverty Issues in Christian Schools: Teachers' Perspectives

    ERIC Educational Resources Information Center

    Bankston, Catherine

    2015-01-01

    The purpose of Christian education is to incorporate Biblical values in the curriculum, and one essential message in the Bible is to reach out and liberate the poor. Through interviews, writing protocols, a focus group meeting, and document analysis, this narrative study focuses on the question of how do Christian educators create pedagogical…

  8. A Model for Addressing Spiritual Issues in Counseling.

    ERIC Educational Resources Information Center

    Russo, Thomas J.

    1984-01-01

    Discusses the hesitancy of counselors and psychotherapists to approach the spiritual concerns of clients. Proposes a counseling and psychotherapy training model that contains discrete yet continuous levels of learning. The holistic epistemology of Gregory Bateson is used to derive guiding theoretical principles for the training model. (Author/JAC)

  9. Developing Social Marketing Capacity to Address Health Issues

    ERIC Educational Resources Information Center

    Whitelaw, S.; Smart, E.; Kopela, J.; Gibson, T.; King, V.

    2011-01-01

    Purpose: Social marketing is increasingly being seen as a potentially effective means of pursuing health education practice generally and within various specific areas such as mental health and wellbeing and more broadly in tackling health inequalities. This paper aims to report and reflect on the authors' experiences of undertaking a health…

  10. Addressing Issues of Workplace Harassment: Counseling the Targets.

    ERIC Educational Resources Information Center

    Lewis, Jacqueline; Coursol, Diane; Wahl, Kay Herting

    2002-01-01

    Workplace harassment includes dysfunctional personal interactions characterized by bullying behaviors, personal attacks, and attempts to denigrate others. Targets of workplace harassment may experience stress, depression, low self-esteem, loss of sleep, and even posttraumatic stress disorder. Strategies that counselors can use to work effectively…

  11. Addressing Machining Issues for the Intermetallic Compound 60-NITINOL

    NASA Technical Reports Server (NTRS)

    Stanford, Malcolm K.; Wozniak, Walter A.; McCue, Terry R.

    2012-01-01

    60-NITINOL (60 wt.% Ni - 40 wt.% Ti) is being studied as a material for advanced aerospace components. Frequent wire breakage during electrical-discharge machining of this material was investigated. The studied material was fabricated from hot isostatically pressed 60-NITINOL powder obtained through a commercial source. Bulk chemical analysis of the material showed that the composition was nominal but had relatively high levels of certain impurities, including Al and O. It was later determined that Al2O3 particles had contaminated the material during the hot isostatic pressing procedure and that these particles were the most likely cause of the wire breakage. The results of this investigation highlight the importance of material cleanliness to its further implementation.

  12. Community Linkages: Addressing Social Issues from a Community Perspective.

    ERIC Educational Resources Information Center

    Borden, Lynne M.

    1999-01-01

    Study of three community collaborations in family violence coordinating councils identified factors influencing sustainability: clearly stated goals, identification of key members, and good internal and external communication. Collaborations succeed when they enable individuals and their organizations to agree on vision, mission, and goals. (SK)

  13. Ethical Issues in Addressing Inequity in/through ESL Research

    ERIC Educational Resources Information Center

    Lee, Ena

    2011-01-01

    This article outlines a researcher's struggles with conducting "ethical" research when her case study reveals racializations faced by a minority teacher in a Canadian ESL program. How might becoming privy to research participants' experiences of inequity in ESL education complicate the notion of research ethics when "doing the right thing" runs…

  14. Addressing the Issue of Teaching English as a Lingua Franca

    ERIC Educational Resources Information Center

    Kuo, I-Chun

    2006-01-01

    The status of English as a lingua franca (ELF) has become an increasingly popular discourse in Applied Linguistics and current ELT. It has been suggested that native speakers and their Englishes have become relatively unimportant in international communication and that research interests should now fall on non-native speakers and their use of…

  15. Obama address touches on research, energy, and environmental issues

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-02-01

    President Barack Obama's State of the Union message, delivered on 24 January, touched on the need for basic research, energy production, support for clean energy, and environmental protection, but it included just one passing reference to climate change. In addition, the speech made no note of the Administration's recent denial of a controversial application for the Keystone XL pipeline to transport crude oil from Canada to the United States and made just an elliptical reference regarding the bankrupt Solyndra Corporation, which the administration had touted as a clean energy company. Innovation "demands basic research," Obama said, adding that Congress should not "gut these investments in our budget." Noting that one promise for innovation is American-made energy, Obama said he is directing the administration to "open more than 75% of our potential offshore oil and gas resources."

  16. Advances in Pediatric Asthma in 2010: Addressing the Major Issues

    PubMed Central

    Szefler, Stanley J.

    2010-01-01

    Last year’s Advances in Pediatric Asthma concluded with the following statement “If we can close these [remaining] gaps through better communication, improvements in the health care system and new insights into treatment, we will move closer to better methods to intervene early in the course of the disease and induce clinical remission as quickly as possible in most children”. This year’s summary will focus on recent advances in pediatric asthma that take steps moving forward as reported in Journal of Allergy and Clinical Immunology publications in 2010. Some of those recent reports show us how to improve asthma management through steps to better understand the natural history of asthma, individualize asthma care, reduce asthma exacerbations, manage inner city asthma, and some potential new ways to use available medications to improve asthma control. It is clear that we have made many significant gains in managing asthma in children but we have a ways to go to prevent asthma exacerbations, alter the natural history of the disease, and to reduce health disparities in asthma care. Perhaps new directions in personalized medicine and improved health care access and communication will help maintain steady progress in alleviating the burden of this disease in children, especially young children. PMID:21211645

  17. ADDRESSING EMERGING ISSUES IN WATER QUALITY THROUGH ENVIRONMENTAL CHEMISTRY

    EPA Science Inventory

    Public concern over cleanliness and safety of source and recreational waters has prompted researchers to look for indicators of water quality. Giving public water authorities multiple tools to measure and monitor levels of chemical contaminants, as well as chemical markers of c...

  18. Integrated strategy urged to address coastal contamination issues

    USGS Publications Warehouse

    Swarzenski, Peter W.; Kvenvolden, Keith A.; Horowitz, Arthur J.; Buchholtz ten Brink, Marilyn

    2001-01-01

    Coastal bays and estuaries are well known for their intrinsic recreational and economic value, yet these ecosystems are also among our most troubled natural environments. Urban development, agriculture, and shipping are just a few examples of human activities that can cause a wide range of deleterious changes within the coastal environment. These alterations, however, occur simultaneously with cycles of natural variability such as climate change. To effectively manage coastal ecosystems, we need to be able to carefully distinguish between anthropogenic and natural causes of change.

  19. Addressing criminality in childhood: is responsivity the central issue?

    PubMed

    Nee, Claire; Ellis, Tom; Morris, Paul; Wilson, Amy

    2013-11-01

    The responsivity principle is the third element of the now well-established risk-need-responsivity (RNR) model of offender rehabilitation. Accruing evidence suggests it is often sacrificed in intervention programs. We aim to demonstrate the central importance of this principle when designing offender interventions by describing the results of a successful, highly responsive intervention for very young children (aged 7 upward) who have offended. A small slice of the offending population as a whole, child offenders are nevertheless tomorrow's serious, violent, and prolific lawbreakers, yet little is understood about what reduces their risk. Recent developments on responsivity are reviewed, before presenting the evaluation indicating significant and sustained drops in risk of recidivism. In-program factors such as the nature and dosage of interventions are examined, alongside outcome data. The article discusses how RNR and other models might apply to this particularly young and underresearched age group. PMID:23070956

  20. Something to "Speak" about: Addressing Sensitive Issues through Literature

    ERIC Educational Resources Information Center

    Jackett, Mark

    2007-01-01

    "Speak," by Laurie Halse Anderson, is one of the most powerful young adult novels to come along in the past decade. It has won numerous awards, including the "School Library Journal" award for "Best Book of the Year," and was a National Book Award Finalist. Despite this acclaim, many English teachers are uncomfortable teaching "Speak" in their…

  1. Assessing Rural Coalitions That Address Safety and Health Issues

    ERIC Educational Resources Information Center

    Burgus, Shari; Schwab, Charles; Shelley, Mack

    2012-01-01

    Community coalitions can help national organizations meet their objectives. Farm Safety 4 Just Kids depends on coalitions of local people to deliver farm safety and health educational programs to children and their families. These coalitions are called chapters. An evaluation was developed to identify individual coalition's strengths and…

  2. Jupiter's Polar Magnetosphere: Outstanding Issues to be Addressed By Juno

    NASA Astrophysics Data System (ADS)

    Kurth, W. S.; Connerney, J. E. P.; McComas, D. J.; Mauk, B.; Gladstone, R.; Adriani, A.; Bagenal, F.; Bolton, S. J.

    2014-12-01

    Juno is on course to enter polar orbit at Jupiter on July 4, 2016. After a small number of preliminary orbits during which the orbital period is reduced, approximately 30 science orbits will be executed to explore the interior of Jupiter, hence, its origin. A second primary objective of the mission, and the subject of this talk, is to carry out the first exploration of Jupiter's polar magnetosphere. All previous missions to Jupiter, including Ulysses, remained at low Jovian latitudes at close range, hence, our knowledge of Jupiter's polar magnetosphere is a composite of remote sensing (such as radio emissions in the hectometric and decametric bands as well as IR and UV images); application of observations of Earth's auroral and polar cap particles, fields, and auroral emissions; and modeling. While these likely inform our expectations of what Juno will actually measure qualitatively, Juno will provide the first in depth exploration of auroral processes at another planet, other than a small number of very brief encounters of Saturn's kilometric radio source region by Cassini. With a reasonably complete suite of in situ magnetospheric measurements coupled with remote sensing, Juno will enable us to compare Jupiter's polar magnetosphere with those expectations. Certainly, understanding the nature of auroral currents and mechanisms for particle acceleration are high on the list of priorities for these studies. In addition, it is expected that Juno will greatly improve our understanding of the mapping of auroral processes from high latitudes and low altitudes to the middle and outer magnetosphere.

  3. Obesity in pregnancy: addressing the issues at the booking appointment.

    PubMed

    Haken, Clara; Fitzsimons, Kate

    2011-03-01

    The recently published Centre for Maternal and Child Enquiries (CMACE) report, Maternal Obesity in the UK: Findings from a National Project, has provided new information on how often we are caring for women who have a body mass index (BMI) of 35 or more, who these women are, the complications and consequences associated with obesity during pregnancy and the preparedness of maternity services to meet these women's needs. Focusing on booking, this article highlights some of the study's key recommendations and discusses the implications for midwives. Accurate calculation of BMI, discussion of dietary advice including supplementation, risk assessment and referral on are all considerations for this consultation. PMID:21473324

  4. PAPERS ADDRESSING SCIENTIFIC ISSUES IN THE RISK ASSESSMENT OF METALS

    EPA Science Inventory

    EPA has recognized the need for consistent application of methods and data to metals risk assessment in consideration of the unique properties of metals. To inform the consideration of metals properties, and to engage the external scientific community, the Agency commissioned ext...

  5. Addressing Issues of Power, Justice, and Privilege in Literacy Instruction

    ERIC Educational Resources Information Center

    Tate, Stacie L.

    2014-01-01

    Tate applauds Rogers's use of teacher research to illustrate how literacy coaches and teachers can approach an accelerative literacy framework with a critical literacy lens. Citing her own work, as well as the work of other critical literacy educators, Tate reminds readers that teacher research is a careful plan that encompasses the power of…

  6. Addressing Correctional Officer Stress: Programs and Strategies. Issues and Practices.

    ERIC Educational Resources Information Center

    Finn, Peter

    A review of the literature and interviews with over 50 people in the field revealed that job-related stress is widespread and possibly increasing among correctional officers. This publication is intended to help correctional administrators develop an effective program for preventing and treating correctional officers' stress. A variety of…

  7. SLIIDEA: Positive Approaches for Addressing Behavioral Issues. inForum

    ERIC Educational Resources Information Center

    Misra, Sunil

    2006-01-01

    When Congress passed the Individuals with Disabilities Education Act (IDEA) in 1997, it authorized an evaluation to track progress at the state and local levels on the legislative goals of IDEA. The U.S. Department of Education's Office of Special Education Programs (OSEP) commissioned a national longitudinal study, the Study of State and Local…

  8. Issues in International Rehabilitation.

    ERIC Educational Resources Information Center

    Nathanson, Jeanne H., Ed.

    1991-01-01

    Eight articles address issues and programs in international rehabilitation. The issue is introduced by a message from the Assistant Secretary of the United States Department of Education for the Office of Special Education and Rehabilitation Services, Robert R. Davila. Next, "A History of International Rehabilitation" (Nora Ellen Groce) reports on…

  9. Issue Brief on Diversity

    ERIC Educational Resources Information Center

    Division on Developmental Disabilities, Council for Exceptional Children (NJ1), 2013

    2013-01-01

    During the past year, the Diversity Committee of the Division of Developmental Disabilities (DDD) Board worked with the Board and the Issues Committee Chair to develop an issue brief addressing diversity, its impact on the membership and the wider community that is served by the work of DDD, resulting in recommendations that will influence policy…

  10. Content addressable memory project

    NASA Technical Reports Server (NTRS)

    Hall, J. Storrs; Levy, Saul; Smith, Donald E.; Miyake, Keith M.

    1992-01-01

    A parameterized version of the tree processor was designed and tested (by simulation). The leaf processor design is 90 percent complete. We expect to complete and test a combination of tree and leaf cell designs in the next period. Work is proceeding on algorithms for the computer aided manufacturing (CAM), and once the design is complete we will begin simulating algorithms for large problems. The following topics are covered: (1) the practical implementation of content addressable memory; (2) design of a LEAF cell for the Rutgers CAM architecture; (3) a circuit design tool user's manual; and (4) design and analysis of efficient hierarchical interconnection networks.

  11. Problem Solvers: Solutions--The Inaugural Address

    ERIC Educational Resources Information Center

    Dause, Emily

    2014-01-01

    Fourth graders in Miss Dause's and Mrs. Hicks's mathematics classes at South Mountain Elementary School in Dillsburg, Pennsylvania, worked with the data from the Inauagural Address problem that was previously published published in the February 2013 issue of "Teaching Children Mathematics". This activity allowed students to…

  12. How Sociology Texts Address Gun Control

    ERIC Educational Resources Information Center

    Tonso, William R.

    2004-01-01

    William R. Tonso has chosen an issue that he knows something about to examine how sociology textbooks address controversy. Appealing for gun control is fashionable, but it is at odds with a fondness that ordinary Americans have for their firearms--one that is supported by a growing body of research on deterrence to crime. There are two sides to…

  13. Opening Address of Chairman Michael Pertschuk.

    ERIC Educational Resources Information Center

    Pertschuk, Michael

    Presented to a symposium sponsored by the Federal Trade Commission (FTC) to consider some of the issues involved in the continuing growth of a few large companies in the field of communication, this address cites statements of concern, made by the Supreme Court and by some periodicals, that excessive concentrations of power threaten First…

  14. Importance of Addressing Sexuality in Certified Rehabilitation Counselor Practice

    ERIC Educational Resources Information Center

    Kazukauskas, Kelly A.; Lam, Chow S.

    2009-01-01

    This study investigated Certified Rehabilitation Counselors' (CRCs) beliefs about the importance of addressing sexuality issues during rehabilitation. A modified version of the Family Life Sex Education Goals Questionnaire (FLSEGQ) was completed by 199 CRCs to determine which issues CRCs believe are most important to address. Six sexuality-related…

  15. 78 FR 44329 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ....nasa.gov/open . Timetable: Action Date FR Cite NPRM 10/00/13 Regulatory Flexibility Analysis Required... analysis is required, and the status of regulations previously reported. ADDRESSES: Acting Assistant... the new accessibility standards. Other amendments include updates to organizational information,...

  16. 78 FR 1634 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... Date FR Cite NPRM 02/00/13 Regulatory Flexibility Analysis Required: No. Agency Contact: Robert W... analysis is required, and the status of regulations previously reported. ADDRESSES: Director, for Internal... accessibility standards. Other amendments include updates to organizational information, use of the...

  17. Content addressable memory project

    NASA Technical Reports Server (NTRS)

    Hall, Josh; Levy, Saul; Smith, D.; Wei, S.; Miyake, K.; Murdocca, M.

    1991-01-01

    The progress on the Rutgers CAM (Content Addressable Memory) Project is described. The overall design of the system is completed at the architectural level and described. The machine is composed of two kinds of cells: (1) the CAM cells which include both memory and processor, and support local processing within each cell; and (2) the tree cells, which have smaller instruction set, and provide global processing over the CAM cells. A parameterized design of the basic CAM cell is completed. Progress was made on the final specification of the CPS. The machine architecture was driven by the design of algorithms whose requirements are reflected in the resulted instruction set(s). A few of these algorithms are described.

  18. Bax: Addressed to kill.

    PubMed

    Renault, Thibaud T; Manon, Stéphen

    2011-09-01

    The pro-apoptototic protein Bax (Bcl-2 Associated protein X) plays a central role in the mitochondria-dependent apoptotic pathway. In healthy mammalian cells, Bax is essentially cytosolic and inactive. Following a death signal, the protein is translocated to the outer mitochondrial membrane, where it promotes a permeabilization that favors the release of different apoptogenic factors, such as cytochrome c. The regulation of Bax translocation is associated to conformational changes that are under the control of different factors. The evidences showing the involvement of different Bax domains in its mitochondrial localization are presented. The interactions between Bax and its different partners are described in relation to their ability to promote (or prevent) Bax conformational changes leading to mitochondrial addressing and to the acquisition of the capacity to permeabilize the outer mitochondrial membrane. PMID:21641962

  19. Utility siting of WECS: A preliminary legal/regulatory assessment

    NASA Astrophysics Data System (ADS)

    Noun, R. J.; Lotker, M.; Frieseman, H. P.

    1981-05-01

    The early experiences of several utilities in dealing with the legal and regulatory issues that were raised in the process of siting wing energy installations were examined. Recommendations are made as to how utilities can begin to address many of the identified issues. Two issues associated with utility siting of wind machines are cited: (1) land acquisition and use and (2) aesthetic controls. Land use control regulations dealing with incompatible uses, nuisance factors, building scale limitations, and on site environmental impacts many constrain wind machine siting by utilities. The siting issue of greatest concern is how the public will react to the hard reality of wind power development. Little public opposition to wind energy projects is raised to date, yet it is possible that local attitudes will change as the novelty of the early single unit machines wears off. It is concluded that potentially adverse impacts based on local aesthetic concerns can be minimized by careful planning, siting, and design by utility developers and by close coordination with local planning and regulatory officials.

  20. 78 FR 1624 - Fall 2012 Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ..., ``Regulatory Planning and Review'' (58 FR 51735, Oct. 4, 1993), as supplemented by Executive Order (EO) 13563, ``Improving Regulation and Regulatory Review'' (76 FR 3821, Jan. 21, 2011); 12898, ``Federal Actions to Address Environmental Justice in Minority Populations and Low-income Populations'' (59 FR 7629, Feb....

  1. 75 FR 79929 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... and Review'' of September 30, 1993, 58 FR 51735 (Oct. 4, 1993). This edition of the Unified Agenda of..., ``Federalism,'' of August 4, 1999, 64 FR 43255 (Aug. 10, 1999), which does not apply to independent regulatory...'s Telemarketing Sales Rule (TSR or Rule) to address the sale of debt relief services (74 FR...

  2. Federal Trade Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... and Review'' of September 30, 1993, 58 FR 51735 (Oct. 4, 1993). This edition of the Unified Agenda of..., ``Federalism,'' of August 4, 1999, 64 FR 43255 (Aug. 10, 1999), which does not apply to independent regulatory...'s Telemarketing Sales Rule (TSR or Rule) to address the sale of debt relief services (74 FR...

  3. 47 CFR 101.1309 - Regulatory status.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Regulatory status. 101.1309 Section 101.1309 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Multiple Address Systems General Provisions § 101.1309 Regulatory status. (a) The Commission...

  4. 47 CFR 101.1309 - Regulatory status.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Regulatory status. 101.1309 Section 101.1309 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Multiple Address Systems General Provisions § 101.1309 Regulatory status. (a) The Commission...

  5. Workshop Addresses Aviation Community

    NASA Astrophysics Data System (ADS)

    Meehan, Jennifer; Kunches, Joseph

    2012-08-01

    Delta Airlines had an unprecedented experience in 2011: For the first time, a flight was rerouted because of space weather activity. Flight 189 from Detroit, Mich., to Beijing, China, had to reroute due to solar activity that occurred 24-28 September 2011. Over the last decade most airlines that fly routes across the North Pole region have had diversions as a result of solar activity. As cross-polar air traffic increases, standing at 10,993 one-way crossings in 2011, the aviation industry is becoming more aware of the impacts that space weather can have on operations, communications, and navigation, as well as the issue of increased radiation exposure for passengers and flight crew on board.

  6. Backlog guidance 'flaw' addressed.

    PubMed

    Langford, Melvyn

    2011-09-01

    In a previous article, in the September 2010 edition of Health Estate Journal, "Is multi-million pound backlog a reality", independent consultant to the healthcare sector, Dr Melvyn Langford, highlighted what he claimed was a "fundamental flaw" in the way the established NHS "5 x 5 criticality grid" used to assess the urgency of backlog maintenance had been interpreted for many years by estates personnel, resulting, he said, in one Trust with a reported 12 million pounds sterling backlog in fact only having a 0.5 m pound sterling "backlog issue". Here he describes an alternative methodology, recently successfully tested with several pilot NHS sites, which he says corrects this flaw, and could have "major implications" for estates and facilities personnel under unprecedented pressure to cut costs. PMID:21961390

  7. Magnetic content addressable memories

    NASA Astrophysics Data System (ADS)

    Jiang, Zhenye

    Content Addressable Memories are designed with comparison circuits built into every bit cell. This parallel structure can increase the speed of searching from O(n) (as with Random Access Memories) to O(1), where n is the number of entries being searched. The high cost in hardware limits the application of CAM within situations where higher searching speed is extremely desired. Spintronics technology can build non-volatile Magnetic RAM with only one device for one bit cell. There are various technologies involved, like Magnetic Tunnel Junctions, off-easy-axis programming method, Synthetic Anti-Ferromagnetic tri-layers, Domain Wall displacement, Spin Transfer Torque tri-layers and etc. With them, particularly the Tunnel Magneto-Resistance variation in MTJ due to difference in magnetization polarity of the two magnets, Magnetic CAM can be developed with reduced hardware cost. And this is demonstrated by the discussion in this dissertation. Six MCAM designs are discussed. In the first design, comparand (C), local information (S) and their complements are stored into 4 MTJs connected in XOR gate pattern. The other five designs have one or two stacks for both information storage and comparison, and full TMR ratio can be taken advantage of. Two challenges for the five are specifically programming C without changing S and selectively programming a cell out of an array. The solutions to specific programming are: by confining the programming field for C in a ring structure design; by using field programming and spin polarized current programming respectively for C and S in the SAF+DW and SAF+STT tri-layer design; by making use of the difference in thresholds between direct mode and toggle mode switching in the SAF+SAF design. The problem of selective programming is addressed by off-easy-axis method and by including SAF tri-layers. Cell with STT tri-layers for both C and S can completely avoid the problems of specific and selective programming, but subject to the limit of

  8. REACTOR PRESSURE VESSEL ISSUES FOR THE LIGHT-WATER REACTOR SUSTAINABILITY PROGRAM

    SciTech Connect

    Nanstad, Randy K; Odette, George Robert

    2010-01-01

    The Light Water Reactor Sustainability Program Plan is a collaborative program between the U.S. Department of Energy and the private sector directed at extending the life of the present generation of nuclear power plants to enable operation to at least 80 years. The reactor pressure vessel (RPV) is one of the primary components requiring significant research to enable such long-term operation. There are significant issues that need to be addressed to reduce the uncertainties in regulatory application, such as, 1) high neutron fluence/long irradiation times, and flux effects, 2) material variability, 3) high-nickel materials, 4)specimen size effects and the fracture toughness master curve, etc. The first issue is the highest priority to obtain the data and mechanistic understanding to enable accurate, reliable embrittlement predictions at high fluences. This paper discusses the major issues associated with long-time operation of existing RPVs and the LWRSP plans to address those issues.

  9. 75 FR 79799 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... agenda pursuant to Executive Order 12866 ``Regulatory Planning and Review,'' 58 FR 51735, and the... rulemaking that was published in the Federal Register on September 30, 2004, at 69 FR 58768, issued under... Enforcement Fairness Act of 1996 (SBREFA). Completed: Reason Date FR Cite Final Action 09/15/10 75 FR...

  10. Small Business Administration Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... PROGRAM Legal Authority: 15 USC 636(a)(31) Abstract: SBA plans to issue regulations for the SBA Express... eligibility determinations. Timetable: Action Date FR Cite NPRM 08/00/10 Regulatory Flexibility Analysis... program. ] Timetable: Action Date FR Cite NPRM 08/00/10 Regulatory Flexibility Analysis Required:...

  11. Federal Trade Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... No. 12866 ``Regulatory Planning and Review'' of September 30, 1993, 58 FR 51735 (Oct. 4, 1993). Since... Final Rule, which the Commission issued jointly with the Federal Reserve on January 15, 2010 (75 FR 2724... Regulatory Plan narrative. 74 FR 64137, 64366. The Commission has also responded to the optional...

  12. 76 FR 75798 - Reducing Regulatory Burden

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ...; ] DEPARTMENT OF ENERGY 5 CFR Chapter XXIII 10 CFR Chapters II, III, X Reducing Regulatory Burden AGENCY: Office... its implementation of Executive Order 13563, ``Improving Regulation and Regulatory Review,'' issued by... General Counsel for Legislation, Regulation, and Energy Efficiency, U.S. Department of Energy, Office...

  13. 76 FR 40050 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ...) pursuant to Executive Order 12866, ``Regulatory Planning and Review,'' 58 FR 51735, and the Regulatory... FR Cite Notice: Public Meeting Framework 09/28/10 75 FR 59657 Document Availibility. Comment Period... Commercial and Industrial Electric Motors. Issued in Washington, DC, on March 1, 2011. Scott Blake...

  14. Environmental Protection Agency Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...:// Not in FR www.epa.gov/lawsregs/search/regagenda.html Semiannual Regulatory Flexibility Agenda www....html issue ] Monthly Action Initiation List http://www.regulations.gov/fdmspublic/component/ Not in FR... Rulemaking Gateway www.epa.gov/rulemaking/ Not in FR B. What Are EPA's Regulatory Goals, and What...

  15. The Democratic Imperative to Address Sexual Equality Rights in Schools

    ERIC Educational Resources Information Center

    Gereluk, Dianne

    2013-01-01

    Issues of sexual orientation elicit ethical debates in schools and society. In jurisdictions where a legal right has not yet been established, one argument commonly rests on whether schools ought to address issues of same-sex relationships and marriage on the basis of civil equality, or whether such controversial issues ought to remain in the…

  16. ATMPs for Cancer Immunotherapy: A Regulatory Overview.

    PubMed

    Galli, Maria Cristina

    2016-01-01

    This chapter discusses European regulatory requirements for development of advanced therapy medicinal products (ATMP) for cancer immunotherapy approaches, describing the framework for clinical trials and for marketing authorization.Regulatory critical issues and challenges for developing ATMP are also discussed, with focus on potency determination, long-term follow-up, comparability, and insertional mutagenesis issues. Some of the most critical features of GMP application to ATMP are also described. PMID:27033211

  17. Education for Homeless Children and Youth Program. Title VII-B of the McKinney-Vento Homeless Assistance Act, As Amended by The No Child Left Behind Act of 2001. Non-Regulatory Guidance.

    ERIC Educational Resources Information Center

    US Department of Education, 2004

    2004-01-01

    This revised non-regulatory guidance for the McKinney-Vento program, which replaces the March 2003 guidance, includes new questions that address the following issues: whether children awaiting foster care placement are eligible for McKinney-Vento services (Item G-10); if children displaced from their homes by a natural disaster are eligible for…

  18. Gender: addressing a critical focus.

    PubMed

    Thornton, L; Wegner, M N

    1995-01-01

    The definition of gender was addressed at the Fourth World Conference on Women (Beijing, China). After extensive debate, the definition developed by the UN Population Fund in 1995 was adopted: "a set of qualities and behaviors expected from a female or male by society." The sustainability of family planning (FP) programs depends on acknowledgment of the role gender plays in contraceptive decision-making and use. For example, programs must consider the fact that women in many cultures do not make FP decisions without the consent of their spouse. AVSC is examining providers' gender-based ideas about clients and the effects of these views on the quality of reproductive health services. Questions such as how service providers can encourage joint responsibility for contraception without requiring spousal consent or how they can make men feel comfortable about using a male method in a society where FP is considered a woman's issue are being discussed. Also relevant is how service providers can discuss sexual matters openly with female clients in cultures that do not allow women to enjoy their sexuality. Another concern is the potential for physical violence to a client as a result of the provision of FP services. PMID:12294397

  19. Regulatory RNAs

    PubMed Central

    Vazquez-Anderson, Jorge; Contreras, Lydia M

    2013-01-01

    RNAs have many important functional properties, including that they are independently controllable and highly tunable. As a result of these advantageous properties, their use in a myriad of sophisticated devices has been widely explored. Yet, the exploitation of RNAs for synthetic applications is highly dependent on the ability to characterize the many new molecules that continue to be discovered by large-scale sequencing and high-throughput screening techniques. In this review, we present an exhaustive survey of the most recent synthetic bacterial riboswitches and small RNAs while emphasizing their virtues in gene expression management. We also explore the use of these RNA components as building blocks in the RNA synthetic biology toolbox and discuss examples of synthetic RNA components used to rewire bacterial regulatory circuitry. We anticipate that this field will expand its catalog of smart devices by mimicking and manipulating natural RNA mechanisms and functions. PMID:24356572

  20. Regulatory Physiology

    NASA Technical Reports Server (NTRS)

    Lane, Helen W.; Whitson, Peggy A.; Putcha, Lakshmi; Baker, Ellen; Smith, Scott M.; Stewart, Karen; Gretebeck, Randall; Nimmagudda, R. R.; Schoeller, Dale A.; Davis-Street, Janis

    1999-01-01

    As noted elsewhere in this report, a central goal of the Extended Duration Orbiter Medical Project (EDOMP) was to ensure that cardiovascular and muscle function were adequate to perform an emergency egress after 16 days of spaceflight. The goals of the Regulatory Physiology component of the EDOMP were to identify and subsequently ameliorate those biochemical and nutritional factors that deplete physiological reserves or increase risk for disease, and to facilitate the development of effective muscle, exercise, and cardiovascular countermeasures. The component investigations designed to meet these goals focused on biochemical and physiological aspects of nutrition and metabolism, the risk of renal (kidney) stone formation, gastrointestinal function, and sleep in space. Investigations involved both ground-based protocols to validate proposed methods and flight studies to test those methods. Two hardware tests were also completed.

  1. Regulatory Anatomy

    PubMed Central

    2015-01-01

    This article proposes the term “safety logics” to understand attempts within the European Union (EU) to harmonize member state legislation to ensure a safe and stable supply of human biological material for transplants and transfusions. With safety logics, I refer to assemblages of discourses, legal documents, technological devices, organizational structures, and work practices aimed at minimizing risk. I use this term to reorient the analytical attention with respect to safety regulation. Instead of evaluating whether safety is achieved, the point is to explore the types of “safety” produced through these logics as well as to consider the sometimes unintended consequences of such safety work. In fact, the EU rules have been giving rise to complaints from practitioners finding the directives problematic and inadequate. In this article, I explore the problems practitioners face and why they arise. In short, I expose the regulatory anatomy of the policy landscape. PMID:26139952

  2. Collective efficacy and the regulatory framing of health messages: influences on concern for body image.

    PubMed

    Johnson-Young, Elizabeth A; Magee, Robert G

    2014-01-01

    A collective efficacy scale is presented and used in 2 experiments that tested the effects of collective efficacy and regulatory framing on concern for body image. In Study 1 (N = 73), participants viewed online video messages from a health campaign that varied in their regulatory frame (promotion vs. prevention), after which they expressed the likelihood that they would discuss it with someone else. In Study 2, participants (N = 307) viewed either a regulatory-framed message or no message, after which they expressed their concern for the issue and their behavioral intentions. Study 2 also introduced moderating variables and addressed potential alternate explanations. Overall, participants who were higher in collective efficacy indicated greater concern for the issue of body image and expressed a greater likelihood to discuss the issue. The messages' regulatory frame also moderated the effect of collective efficacy. Collective efficacy was a stronger predictor in the prevention condition than in the promotion condition, presumably because the promotion frame was more effective in increasing participants' concern and intentions regardless of their sense of collective efficacy. PMID:24377398

  3. Regulatory pathways for vaccines for developing countries.

    PubMed Central

    Milstien, Julie; Belgharbi, Lahouari

    2004-01-01

    Vaccines that are designed for use only in developing countries face regulatory hurdles that may restrict their use. There are two primary reasons for this: most regulatory authorities are set up to address regulation of products for use only within their jurisdictions and regulatory authorities in developing countries traditionally have been considered weak. Some options for regulatory pathways for such products have been identified: licensing in the country of manufacture, file review by the European Medicines Evaluation Agency on behalf of WHO, export to a country with a competent national regulatory authority (NRA) that could handle all regulatory functions for the developing country market, shared manufacturing and licensing in a developing country with competent manufacturing and regulatory capacity, and use of a contracted independent entity for global regulatory approval. These options have been evaluated on the basis of five criteria: assurance of all regulatory functions for the life of the product, appropriateness of epidemiological assessment, applicability to products no longer used in the domestic market of the manufacturing country, reduction of regulatory risk for the manufacturer, and existing rules and regulations for implementation. No one option satisfies all criteria. For all options, national infrastructures (including the underlying regulatory legislative framework, particularly to formulate and implement local evidence-based vaccine policy) must be developed. WHO has led work to develop this capacity with some success. The paper outlines additional areas of action required by the international community to assure development and use of vaccines needed for the developing world. PMID:15042235

  4. 75 FR 70044 - Withdrawal of Regulatory Guide 1.39

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Development Branch, Division of Engineering, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory... of RG 1.28 and RG 1.33 adequately address the related Quality Assurance Program with the latest ANSI... Development Branch, Division of Engineering, Office of Nuclear Regulatory Research. BILLING CODE 7590-01-P...

  5. Ensuring accountability through health professional regulatory bodies: the case of conflict of interest.

    PubMed

    Zelisko, Debra; Baumann, Andrea; Gamble, Brenda; Laporte, Audrey; Deber, Raisa B

    2014-09-01

    How do self-regulated health professions' regulatory bodies address financial conflict of interest (coi) and ensure accountability to the public? using document analysis, we examined how four ontario regulatory colleges (physicians, nurses, physiotherapists, audiologists/speech-language pathologists) defined coi and the education, guidance and enforcement they provided for coi-related issues. These colleges are upholding the mandates to define, identify and address financial coi by providing regulations or standards and guidelines to their membership; they differed in the amount of educational materials provided to their registrants and in the possible coi scenarios they presented. Although there were few disciplinary hearings pertaining to financial coi, findings for the hearings that did occur were documented and posted on the college public registers (the listing of all registered college members along with all relevant practice information), informing the public of any limitations or restrictions placed on a member as a result of the hearing. PMID:25305394

  6. Ensuring Accountability through Health Professional Regulatory Bodies: The Case of Conflict of Interest

    PubMed Central

    Zelisko, Debra; Baumann, Andrea; Gamble, Brenda; Laporte, Audrey; Deber, Raisa B.

    2014-01-01

    How do self-regulated health professions' regulatory bodies address financial conflict of interest (COI) and ensure accountability to the public? Using document analysis, we examined how four Ontario regulatory colleges (physicians, nurses, physiotherapists, audiologists/speech-language pathologists) defined COI and the education, guidance and enforcement they provided for COI-related issues. These colleges are upholding the mandates to define, identify and address financial COI by providing regulations or standards and guidelines to their membership; they differed in the amount of educational materials provided to their registrants and in the possible COI scenarios they presented. Although there were few disciplinary hearings pertaining to financial COI, findings for the hearings that did occur were documented and posted on the college public registers (the listing of all registered college members along with all relevant practice information), informing the public of any limitations or restrictions placed on a member as a result of the hearing. PMID:25305394

  7. Critical Issues Facing School Principals

    ERIC Educational Resources Information Center

    Styron, Ronald A., Jr.; Styron, Jennifer L.

    2011-01-01

    The purpose of this study was to further extend research initially conducted in 2003 pertaining to the critical issues K-12 principals address on a daily basis. The study involved surveying school principals within the state of Mississippi to discover the critical issues they identified, the significance level of these issues, and the rationale…

  8. Multicultural Issues.

    ERIC Educational Resources Information Center

    Reid, Charrles; Kampfe, Charlene

    This chapter examines issues related to working with diverse populations with addictions. A brief history of multiculturalism and multicultural counseling is presented. Issues particular to the treatment of people with addictions are examined, as well as prevention and assessment issues. Substance abuse issues among people in the gay male and…

  9. 76 FR 19817 - Final Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... Federal Register Notice was issued (74 FR 39343) announcing the availability of DG-5034 for public comment... COMMISSION Final Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Regulatory Guide (RG) 5.79, ``Protection of Safeguards...

  10. Management of contaminated structures at federal facilities : reuse considerations and other major issues.

    SciTech Connect

    Davis, M. J.; Picel, K. C.; Environmental Assessment

    2000-01-01

    The management of contaminated structures can be a major activity at some federal facilities and generally differs from management of contaminated environmental media. In particular, a major issue associated with a contaminated structure is whether there is a realistic potential for future use of the structure. This issue should be addressed early in a planning process. The resolution of this issue significantly affects other major issues associated with management of a contaminated structure such as: (1) What are the expected costs associated with management of the structure? (2) What regulatory requirements are applicable? (3) What characterization is needed? (4) What risk assessment is necessary? and (5) What remediation decisions must be made? This article considers all of these issues.

  11. 2014 ASHG Awards and Addresses

    PubMed Central

    2015-01-01

    Each year at the annual meeting of The American Society of Human Genetics (ASHG), addresses are given in honor of The Society and a number of award winners. A summary of each of these addresses is given below. On the following pages, we have printed the presidential address and the addresses for the William Allan Award, the Curt Stern Award, and the Victor A. McKusick Leadership Award. Webcasts of these addresses, as well as those of many other presentations, can be found at http://www.ashg.org.

  12. 2013 ASHG Awards and Addresses

    PubMed Central

    2014-01-01

    Each year at the annual meeting of The American Society of Human Genetics (ASHG), addresses are given in honor of The Society and a number of award winners. A summary of each of these addresses is given below. On the following pages, we have printed the Presidential Address and the addresses for the William Allan Award, the Curt Stern Award, and the Victor A. McKusick Leadership Award. Webcasts of these addresses, as well as those of many other presentations, can be found at http://www.ashg.org.

  13. 78 FR 40776 - Issuance of Regulatory Guide 1.124 and Regulatory Guide 1.130

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ...The U.S. Nuclear Regulatory Commission (NRC) is issuing Revision 3 of Regulatory Guide (RG) 1.124, ``Service Limits and Loading Combinations for Class 1 Linear-Type Supports,'' and Revision 3 of RG 1.130, ``Service Limits and Loading Combinations for Class 1 Plate-and- Shell-Type Supports.'' There are no substantive changes to these regulatory guides. The revisions include an update of the......

  14. ADDRESSING ENVIRONMENTAL ENGINEERING CHALLENGES WITH COMPUTATIONAL FLUID DYNAMICS

    EPA Science Inventory

    In the field of environmental engineering, modeling tools are playing an ever larger role in addressing air quality issues, including source pollutant emissions, atmospheric dispersion and human exposure risks. More detailed modeling of environmental flows requires tools for c...

  15. Current issues with research support

    SciTech Connect

    Russell, W.T.

    1996-03-01

    It would be difficult to condense current issues in nuclear reactor regulation to just a few minutes. So, let me start off by saying that I have not tried to give a comprehensive listing of issues that are currently facing the reactor program, but rather to select those that I thought were relevant as they relate to research activities. Use of probabilistic risk assessment in regulatory decisions; materials aging issues concerning steam generators and reactor vessels; high burnup fuels; accident management; and digital instrumentation and control, are just a sampling of the important issues that I want to talk about.

  16. Global regulatory standards for the approval of biosimilars.

    PubMed

    Mounho, Barbara; Phillips, Audrey; Holcombe, Kay; Grampp, Gustavo; Lubiniecki, Tony; Mollerup, Inger; Jones, Carolyn

    2010-01-01

    On March 23, 2010, President Barack Obama signed into law the Patient Protection and Affordable Care Act, which contains the Biologics Price Competition and Innovation Act. Biosimilars have an important role in the United States health care system, and this new law creates an abbreviated approval pathway for biosimilar products in the U.S. A biosimilar is a biologic product demonstrated to be highly similar to an approved innovator biologic product ("reference product"). While the law provides general information on the standards to demonstrate biosimilarity, Congress has authorized the FDA to define the scientific standards and content of biosimilar applications. There is an increasing global interest in the development of biosimilar products, and several regulatory authorities around the world, as well as the World Health Organization (WHO), have established regulatory guidelines for the approval of biosimilars. The scientific standards and requirements in the biosimilar guidelines of the WHO and other health authorities, including the European Union, Canada, Japan, and South Africa, are reviewed in this paper. The similarities as well as the differences among the policies adopted by these regulatory authorities may provide the FDA valuable information as the agency develops its standards and approaches for the approval of biosimilars in the U.S. At the same time, while establishing such approaches, the FDA has the opportunity to demonstrate leadership in addressing significant safety and other issues related to multi-source biologics and biosimilars that remain a global challenge. PMID:24479248

  17. Environmental regulatory drivers for coal bed methane research and development.

    SciTech Connect

    Elcock, D.; Gasper, J.; Moses, D. O.

    2002-10-10

    In 1999, the National Petroleum Council (NPC) stated that the resource base for meeting growing natural gas demands in the United States is adequate. A significant and increasing portion of natural gas production (8% by 2015) is expected to come from coal bed methane (CBM). The NPC cautions that for this to occur, certain factors, including compliance with environmental requirements, must be addressed. Numerous federal, state, and local programs address a variety of environmental issues, including water quality and quantity, air quality, wildlife, noise, and visibility. This paper examines existing and potential environmental regulatory requirements that could affect the timely development and production of CBM resources in the United States. Such an examination can help technology developers and policy makers target areas for research and development (R&D), demonstration, and implementation to help facilitate cost-effective CBM development and production to meet the nation's natural gas demands. It can also help identify R&D areas that will give rule-making bodies the information they need to incorporate more science into the regulatory development process.

  18. Special Issue of Teaching Ideas.

    ERIC Educational Resources Information Center

    Health Education (Washington D.C.), 1986

    1986-01-01

    This special issue contains teaching strategies and suggestions for health-related activities at all educational levels. A few of the topics addressed by the 21 articles are heart disease, testicular cancer, hospital stress, family life, and sexual responsibility. (MT)

  19. Addressing Stereotypes by Moving along the Continuum of Cultural Proficiency

    ERIC Educational Resources Information Center

    Ward, Cheryl James

    2013-01-01

    Programs to help middle school students deal with racism and hate have been in place for some years, yet almost monthly we hear of students committing suicide or killing other students due to issues of isolation or harassment. Within the confines of a safe classroom, doctoral students in Educational Leadership addressed issues of stereotypes and…

  20. Addressing Barriers to Learning. Volume 10, Number 1. Winter 2005

    ERIC Educational Resources Information Center

    Center for Mental Health in Schools at UCLA, 2005

    2005-01-01

    This issue of the quarterly newsletter of the Center for Mental Health in Schools builds on the Fall 2001 newsletter dealing with bullying as a major barrier to student learning. This issue includes the following features and regular segments: (1) Bullying and Addressing Barriers to Learning; (2) Research into Practice: Screening for Depression;…

  1. Generic medicines: issues and relevance for global health.

    PubMed

    Rana, Proteesh; Roy, Vandana

    2015-12-01

    Generic medicine is a pharmaceutical product which is bioequivalent to the innovator product in terms of dosage form, strength, route of administration, quality, safety, performance characteristics, and intended use. Generic medicines are a cornerstone for providing affordable medicines to patients. The major generic markets in the world include United States of America followed by European Union, Canada, Japan, and Australia. The major suppliers of generic medicines China and India are showing tremendous growth in the generic medicine sector. There are many legal and regulatory issues along with quality concerns associated with the use of the generic products. Lately, bilateral international agreements called free trade agreements, delaying tactics by originator companies like strategic patenting and litigations on generic manufacturers, have been a major setback for the generic medicine industry. These issues need to be addressed to optimize the use of generic medicines. The sustainability of generic medicine sector is crucial for improving access to essential medicines for the worldwide. PMID:26405851

  2. Computational architecture of the yeast regulatory network

    NASA Astrophysics Data System (ADS)

    Maslov, Sergei; Sneppen, Kim

    2005-12-01

    The topology of regulatory networks contains clues to their overall design principles and evolutionary history. We find that while in- and out-degrees of a given protein in the regulatory network are not correlated with each other, there exists a strong negative correlation between the out-degree of a regulatory protein and in-degrees of its targets. Such correlation positions large regulatory modules on the periphery of the network and makes them rather well separated from each other. We also address the question of relative importance of different classes of proteins quantified by the lethality of null-mutants lacking one of them as well as by the level of their evolutionary conservation. It was found that in the yeast regulatory network highly connected proteins are in fact less important than their low-connected counterparts.

  3. Genetic Issues in Mental Retardation, 1996-1997.

    ERIC Educational Resources Information Center

    Genetic Issues in Mental Retardation, 1996

    1996-01-01

    This document consists of the first six issues of a newsletter, which discusses current knowledge about and concerns related to genetics and mental retardation. The second issue addresses the problem of genetic discrimination. The third issue considers genetic testing, screening, and counseling. The fourth issue addresses genetic privacy issues.…

  4. 2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 1 - small molecules by LCMS).

    PubMed

    Welink, Jan; Fluhler, Eric; Hughes, Nicola; Arnold, Mark; Garofolo, Fabio; Bustard, Mark; Coppola, Laura; Dhodda, Raj; Evans, Christopher; Gleason, Carol; Haidar, Sam; Hayes, Roger; Heinig, Katja; Katori, Noriko; Blaye, Olivier Le; Li, Wenkui; Liu, Guowen; Lima Santos, Gustavo Mendes; Meng, Min; Nicholson, Bob; Savoie, Natasha; Skelly, Michael; Sojo, Luis; Tampal, Nilufer; de Merbel, Nico van; Verhaeghe, Tom; Vinter, Stephen; Wickremsinhe, Enaksha; Whale, Emma; Wilson, Amanda; Witte, Bärbel; Woolf, Eric

    2015-01-01

    The 2015 9th Workshop on Recent Issues in Bioanalysis (9th WRIB) took place in Miami, Florida with participation of over 600 professionals from pharmaceutical and biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. It is once again a 5-day week long event - a full immersion bioanalytical week - specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest in bioanalysis. The topics covered included both small and large molecules, and involved LCMS, hybrid LBA/LCMS, LBA approaches including the focus on biomarkers and immunogenicity. This 2015 White Paper encompasses recommendations that emerged from the extensive discussions held during the workshop, and is aimed to provide the bioanalytical community with key information and practical solutions on topics and issues addressed, in an effort to advance scientific excellence, improve quality and deliver better regulatory compliance. Due to its length, the 2015 edition of this comprehensive White Paper has been divided into three parts. Part 1 covers the recommendations for small molecule bioanalysis using LCMS. Part 2 (hybrid LBA/LCMS and regulatory agencies' inputs) and Part 3 (large molecule bioanalysis using LBA, biomarkers and immunogenicity) will also be published in volume 7 of Bioanalysis, issues 23 and 24, respectively. PMID:26573485

  5. 2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 3--LBA, biomarkers and immunogenicity).

    PubMed

    Amaravadi, Lakshmi; Song, An; Myler, Heather; Thway, Theingi; Kirshner, Susan; Devanarayan, Viswanath; Ni, Yan G; Garofolo, Fabio; Birnboeck, Herbert; Richards, Susan; Gupta, Shalini; Luo, Linlin; Kingsley, Clare; Salazar-Fontana, Laura; Fraser, Stephanie; Gorovits, Boris; Allinson, John; Barger, Troy; Chilewski, Shannon; Fjording, Marianne Scheel; Haidar, Sam; Islam, Rafiqul; Jaitner, Birgit; Kamerud, John; Katori, Noriko; Krinos-Fiorotti, Corinna; Lanham, David; Ma, Mark; McNally, Jim; Morimoto, Alyssa; Mytych, Daniel; Nogueira da Costa, Andre; Papadimitriou, Apollon; Pillutla, Renuka; Ray, Soma; Safavi, Afshin; Savoie, Natasha; Schaefer, Martin; Shih, Judy; Smeraglia, John; Skelly, Michael F; Spond, Jeffrey; Staack, Roland F; Stouffer, Bruce; Tampal, Nilufer; Torri, Albert; Welink, Jan; Yang, Tong-Yuan; Zoghbi, Jad

    2015-12-01

    The 2015 9th Workshop on Recent Issues in Bioanalysis (9th WRIB) took place in Miami, Florida with participation of 600 professionals from pharmaceutical and biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5 day, week-long event - A Full Immersion Bioanalytical Week - specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest in bioanalysis. The topics covered included both small and large molecules, and involved LCMS, hybrid LBA/LCMS and LBA approaches, including the focus on biomarkers and immunogenicity. This 2015 White Paper encompasses recommendations emerging from the extensive discussions held during the workshop, and is aimed to provide the bioanalytical community with key information and practical solutions on topics and issues addressed, in an effort to enable advances in scientific excellence, improved quality and better regulatory compliance. Due to its length, the 2015 edition of this comprehensive White Paper has been divided into three parts. Part 3 discusses the recommendations for large molecule bioanalysis using LBA, biomarkers and immunogenicity. Part 1 (small molecule bioanalysis using LCMS) and Part 2 (hybrid LBA/LCMS and regulatory inputs from major global health authorities) have been published in volume 7, issues 22 and 23 of Bioanalysis, respectively. PMID:26635247

  6. Regulatory guidance on soil cover systems

    SciTech Connect

    Kane, J.D.

    1991-12-31

    The US Nuclear Regulatory Commission (NRC) in September 1991, completed revisions to 14 sections of the Standard Review Plan (SRP) for the Review of a License Application for a Low-Level Radioactive Waste Disposal Facility. The major purposes of the SRP are to ensure the quality and uniformity of the NRC staff`s safety reviews, and to present a well-defined base from which to evaluate the acceptability of information and data provided in the Safety Analysis Report (SAR) portion of the license application. SRP 3.2, entitled, Design Considerations for Normal and Abnormal/Accident Conditions, was one of the sections that was revised by the NRC staff. This revision was completed to provide additional regulatory guidance on the important considerations that need to be addressed for the proper design and construction of soil cover systems that are to be placed over the LLW. The cover system over the waste is acknowledged to be one of the most important engineered barriers for the long-term stable performance of the disposal facility. The guidance in revised SRP 3.2 summarizes the previous efforts and recommendations of the US Army Corps of Engineers (COE), and a peer review panel on the placement of soil cover systems. NRC published these efforts in NUREG/CR-5432. The discussions in this paper highlight selected recommendations on soil cover issues that the NRC staff considers important for ensuring the safe, long-term performance of the soil cover systems. The development phases to be discussed include: (1) cover design; (2) cover material selection; (3) laboratory and field testing; (4) field placement control and acceptance; and (5) penetrations through the constructed covers.

  7. Issues related to setting exemption levels for oil and gas NORM

    SciTech Connect

    Blunt, D. L.; Gooden, D. S.; Smith, K. P.

    1999-11-12

    In the absence of any federal regulations that specifically address the handling and disposal of wastes containing naturally occurring radioactive material (NORM), individual states have taken responsibility for developing their own regulatory programs for NORM. A key issue in developing NORM rules is defining exemption levels--specific levels or concentrations that determine which waste materials are subject to controlled management. In general, states have drawn upon existing standards and guidelines for similar waste types in establishing exemption levels for NORM. Simply adopting these standards may not be appropriate for oil and gas NORM for several reasons. The Interstate Oil and Gas Compact Commission's NORM Subcommittee has summarized the issues involved in setting exemption levels in a report titled ``Naturally Occurring Radioactive Materials (NORM): Issues from the Oil and Gas Point of View''. The committee has also recommended a set of exemption levels for controlled practices and for remediation activities on the basis of the issues discussed.

  8. Best Practices in Hiring: Addressing Unconscious Bias

    NASA Astrophysics Data System (ADS)

    Simpson, Caroline E.

    2012-01-01

    Research has shown that implementing certain hiring practices will increase diversity in the workplace while enhancing academic quality. All of these practices rely on addressing the issue of 'unconscious bias.' A brief overview of unconscious bias--what it is, how it works, and simple measures to counter it--will be presented. Successful strategies, actions, and recommendations for implementing best recruiting and hiring practices, which have been proven to enhance academic excellence by ensuring a deep and diverse applicant pool, will also be presented.

  9. Addressing the challenges of emerging infectious disease.

    PubMed

    Pinner, R W

    1996-01-01

    Through the recent examples of diphtheria in the former Soviet Union, plague in India, and trends in pneumonia mortality in the United States, the author, in this article, illustrates issues in emerging infectious diseases. The Centers for Disease Control's plan, Addressing Emerging Infectious Disease Threats: A Prevention Strategy for the United States, is summarized. Initial efforts to implement this plan are described, with particular focus on the development of Emerging Infections Programs, which are conducting epidemiologic and laboratory projects on several infectious diseases, including invasive bacterial diseases, unexplained deaths, foodborne diseases, and ehrlichiosis in four population-based sites in the United States. PMID:8571983

  10. Regulatory impact analysis for the NO{sub x} SIP call, FIP, and Section 126 petitions. Volume 2: Health and welfare benefits

    SciTech Connect

    1998-12-01

    This document presents a Regulatory Impact Analysis for the final NO{sub x} SIP call rule, which addresses regional transport issues related to ozone attainment. This analysis expands and updates the previous analyses, to reflect the provisions of the final rule and to provide analysis of the potential benefits and economic impacts as well as the costs, emissions reductions and air quality impacts associated with the rule.

  11. Reading the Tea Leaves: How Utilities in the West Are Managing Carbon Regulatory Risk in their Resource Plans

    SciTech Connect

    Barbose, Galen; Wiser, Ryan; Phadke, Amol; Goldman, Charles

    2008-02-01

    The long economic lifetime and development lead-time of many electric infrastructure investments requires that utility resource planning consider potential costs and risks over a lengthy time horizon. One long-term -- and potentially far-reaching -- risk currently facing the electricity industry is the uncertain cost of future carbon dioxide (CO2) regulations. Recognizing the importance of this issue, many utilities (sometimes spurred by state regulatory requirements) are beginning to actively assess carbon regulatory risk within their resource planning processes, and to evaluate options for mitigating that risk. However, given the relatively recent emergence of this issue and the rapidly changing political landscape, methods and assumptions used to analyze carbon regulatory risk, and the impact of this analysis on the selection of a preferred resource portfolio, vary considerably across utilities. In this study, we examine the treatment of carbon regulatory risk in utility resource planning, through a comparison of the most-recent resource plans filed by fifteen investor-owned and publicly-owned utilities in the Western U.S. Together, these utilities account for approximately 60percent of retail electricity sales in the West, and cover nine of eleven Western states. This report has two related elements. First, we compare and assess utilities' approaches to addressing key analytical issues that arise when considering the risk of future carbon regulations. Second, we summarize the composition and carbon intensity of the preferred resource portfolios selected by these fifteen utilities and compare them to potential CO2 emission benchmark levels.

  12. Issues Curriculum.

    ERIC Educational Resources Information Center

    Sando, Joe S.

    A program for teaching techniques of critical thinking on issues concerning American Indians was developed for students at Albuquerque Indian School. It was designed to include not only the students but also their families with learning activities that required consultation in search of answers or understanding. The first issue presented sought to…

  13. 78 FR 1568 - Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ...The Secretary of Education publishes a semiannual agenda of Federal regulatory and deregulatory actions. The agenda is issued under the authority of section 4(b) of Executive Order 12866 ``Regulatory Planning and Review.'' The purpose of the agenda is to encourage more effective public participation in the regulatory process by providing the public with early information about regulatory......

  14. 76 FR 11163 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Chapter V 48 CFR Chapter 28 Reducing Regulatory Burden; Retrospective Review Under E.O. 13563 AGENCY... Order 13563, ``Improving Regulation and Regulatory Review,'' issued by the President on January 18, 2011..., the President issued Executive Order 13563, ``Improving Regulation and Regulatory Review,'' to...

  15. Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns.

    PubMed

    Miyara, Makoto; Sakaguchi, Shimon

    2011-03-01

    Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self-tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3(+) Tregs and to what extent they are similar to or different from the murine counterparts. We also discuss important issues that remain to be addressed in the field to better understand the pathophysiology of autoimmune disease and to build solid basis for immunotherapies targeting FoxP3(+) Tregs. PMID:21301480

  16. Addressing Fission Product Validation in MCNP Burnup Credit Criticality Calculations

    SciTech Connect

    Mueller, Don; Bowen, Douglas G; Marshall, William BJ J

    2015-01-01

    The US Nuclear Regulatory Commission (NRC) Division of Spent Fuel Storage and Transportation issued Interim Staff Guidance (ISG) 8, Revision 3 in September 2012. This ISG provides guidance for NRC staff members’ review of burnup credit (BUC) analyses supporting transport and dry storage of pressurized water reactor spent nuclear fuel (SNF) in casks. The ISG includes guidance for addressing validation of criticality (keff) calculations crediting the presence of a limited set of fission products and minor actinides (FP&MAs). Based on previous work documented in NRC Regulatory Guide (NUREG) Contractor Report (CR)-7109, the ISG recommends that NRC staff members accept the use of either 1.5 or 3% of the FP&MA worth—in addition to bias and bias uncertainty resulting from validation of keff calculations for the major actinides in SNF—to conservatively account for the bias and bias uncertainty associated with the specified unvalidated FP&MAs. The ISG recommends (1) use of 1.5% of the FP&MA worth if a modern version of SCALE and its nuclear data are used and (2) 3% of the FP&MA worth for well qualified, industry standard code systems other than SCALE with the Evaluated Nuclear Data Files, Part B (ENDF/B),-V, ENDF/B-VI, or ENDF/B-VII cross sections libraries. The work presented in this paper provides a basis for extending the use of the 1.5% of the FP&MA worth bias to BUC criticality calculations performed using the Monte Carlo N-Particle (MCNP) code. The extended use of the 1.5% FP&MA worth bias is shown to be acceptable by comparison of FP&MA worths calculated using SCALE and MCNP with ENDF/B-V, -VI, and -VII–based nuclear data. The comparison supports use of the 1.5% FP&MA worth bias when the MCNP code is used for criticality calculations, provided that the cask design is similar to the hypothetical generic BUC-32 cask model and that the credited FP&MA worth is no more than 0.1 Δkeff (ISG-8, Rev. 3, Recommendation 4).

  17. Concrete Masonry Designs: Educational Issue.

    ERIC Educational Resources Information Center

    Hertzberg, Randi, Ed.

    2001-01-01

    This special journal issue addresses concrete masonry in educational facilities construction. The issue's feature articles are: (1) "It Takes a Village To Construct a Massachusetts Middle School," describing a middle school constructed almost entirely of concrete masonry and modeled after a typical small New England village; (2) "Lessons Learned,"…

  18. Computer Technology and Social Issues.

    ERIC Educational Resources Information Center

    Garson, G. David

    Computing involves social issues and political choices. Issues such as privacy, computer crime, gender inequity, disemployment, and electronic democracy versus "Big Brother" are addressed in the context of efforts to develop a national public policy for information technology. A broad range of research and case studies are examined in an attempt…

  19. Ethnic Studies: Issues and Approaches.

    ERIC Educational Resources Information Center

    Yang, Philip Q.

    This book offers a comprehensive definition of the field of ethnic studies, covering both major issues in the field and its theoretical and methodological approaches. It traces the origins and evolution of the discipline in the United States and maps its domain. Some of the current issues addressed include affirmative action, illegal/legal…

  20. Drugs. Social Issues Resources Series.

    ERIC Educational Resources Information Center

    Goldstein, Eleanor C.; And Others

    The Social Issues Resources Series (SIRS) is a set of loose leaf units each of which is addressed to a different social issue. Each unit consists of articles which have been reproduced from newspapers, magazines, journals and government publications representing the prevailing spectrum of opinion, emphasis and complexity. Sixty articles are…

  1. Regulatory Streamlining and Improvement

    SciTech Connect

    Mark A. Carl

    2006-07-11

    The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FC26-04NT15456 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under future scopes of work submitted annually to DOE's Project Officer for this grant. This report discusses the progress of the projects outlined under the grant scope of work for the 2005-2006 areas of interest, which are as follows: Area of Interest No. 1--Regulatory Streamlining and Improvement: This area of interest continues to support IOGCC's regulatory streamlining efforts that include the identification and elimination of unnecessary duplications of efforts between and among state and federal programs dealing with exploration and production on public lands. Area of Interest No. 2--Technology: This area of interest seeks to improve efficiency in states through the identification of technologies that can reduce costs. Area of Interest No. 3--Training and Education: This area of interest is vital to upgrading the skills of regulators and industry alike. Within the National Energy Policy, there are many appropriate training and education opportunities. Education was strongly endorsed by the President's National Energy Policy Development group. Acting through the governors offices, states are very effective conduits for the dissemination of energy education information. While the IOGCC favors the development of a comprehensive, long-term energy education plan, states are also supportive of immediate action on important concerns, such as energy prices, availability and conservation. Area of Interest No. 4--Resource Assessment and Development: This area

  2. Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop.

    PubMed

    Ramirez, Tzutzuy; Beken, Sonja; Chlebus, Magda; Ellis, Graham; Griesinger, Claudius; De Jonghe, Sandra; Manou, Irene; Mehling, Annette; Reisinger, Kerstin; Rossi, Laura H; van Benthem, Jan; van der Laan, Jan Willem; Weissenhorn, Renate; Sauer, Ursula G

    2015-10-01

    The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a workshop Knowledge sharing to facilitate regulatory decision-making. Fifty invited participants from the European Commission, national and European agencies and bodies, different industry sectors (chemicals, cosmetics, fragrances, pharmaceuticals, vaccines), and animal protection organizations attended the workshop. Four case studies exemplarily revealed which procedures are in place to obtain regulatory acceptance of new test methods in different sectors. Breakout groups discussed the status quo identifying the following facilitators for regulatory acceptance of alternatives to animal testing: Networking and communication (including cross-sector collaboration, international cooperation and harmonization); involvement of regulatory agencies from the initial stages of test method development on; certainty on prerequisites for test method acceptance including the establishment of specific criteria for regulatory acceptance. Data sharing and intellectual property issues affect many aspects of test method development, validation and regulatory acceptance. In principle, all activities should address replacement, reduction and refinement methods (albeit animal testing is generally prohibited in the cosmetics sector). Provision of financial resources and education support all activities aiming at facilitating the acceptance and use of alternatives to animal testing. Overall, workshop participants recommended building confidence in new methodologies by applying and gaining experience with them. PMID:26188116

  3. Copyright, the Internet, and Other Legal Issues.

    ERIC Educational Resources Information Center

    Gasaway, Laura N.

    1998-01-01

    Copyright and other intellectual property issues have dominated discussions of legal issues surrounding the Internet. There are other issues of considerable importance that also attract attention. Five legal issues affecting the Internet are addressed: copyright, online service-provider liability, database protection, obscenity, and privacy. Cited…

  4. Issues management made easier

    SciTech Connect

    Brownson, L.

    1993-10-01

    Increases in ES&H compliance issues within the past few years have necessitated a formal process by which DOE facilities address these issues. In May 1991, ANL-W implemented the ANL-W Issues Management System (IMS) to facilitate the management of compliance issues and scheduling of corrective action plans with limited resources. The central focus of this process is a computer database, Integrated Resource Management System (IRMS), which allows quick retrieval of compliance information, organization of compliance issues based on a risk-based prioritization methodology, and tracking of corrective action plans. Without the IRMS, the ANL-W Issues Management System would have been difficult to administer and manage. ANL-W has used the IRMS for both audit preparation and audit response, most noticeably the preparation and subsequent response to the 1991 Tiger Team audit. The IRMS was used to track ANL-W Self-Assessment corrective action plans, provide instant information to Tiger Team members regarding Self-Assessment findings, produce prioritized lists of Tiger Team concerns for developing corrective action plans, and track Tiger Team corrective action plans. Status reports to senior, laboratory management regarding the Tiger Team corrective action plan are produced based on information provided by the IRMS. This paper discusses the criteria used for selecting the IRMS, implementation of the Issues Management System using the IRMS, lessons learned, and the future evolution of the IRMS.

  5. Addressing Risks to Advance Mental Health Research

    PubMed Central

    Iltis, Ana S.; Misra, Sahana; Dunn, Laura B.; Brown, Gregory K.; Campbell, Amy; Earll, Sarah A.; Glowinski, Anne; Hadley, Whitney B.; Pies, Ronald; DuBois, James M.

    2015-01-01

    Objective Risk communication and management are essential to the ethical conduct of research, yet addressing risks may be time consuming for investigators and institutional review boards (IRBs) may reject study designs that appear too risky. This can discourage needed research, particularly in higher risk protocols or those enrolling potentially vulnerable individuals, such as those with some level of suicidality. Improved mechanisms for addressing research risks may facilitate much needed psychiatric research. This article provides mental health researchers with practical approaches to: 1) identify and define various intrinsic research risks; 2) communicate these risks to others (e.g., potential participants, regulatory bodies, society); 3) manage these risks during the course of a study; and 4) justify the risks. Methods As part of a National Institute of Mental Health (NIMH)-funded scientific meeting series, a public conference and a closed-session expert panel meeting were held on managing and disclosing risks in mental health clinical trials. The expert panel reviewed the literature with a focus on empirical studies and developed recommendations for best practices and further research on managing and disclosing risks in mental health clinical trials. IRB review was not required because there were no human subjects. The NIMH played no role in developing or reviewing the manuscript. Results Challenges, current data, practical strategies, and topics for future research are addressed for each of four key areas pertaining to management and disclosure of risks in clinical trials: identifying and defining risks, communicating risks, managing risks during studies, and justifying research risks. Conclusions Empirical data on risk communication, managing risks, and the benefits of research can support the ethical conduct of mental health research and may help investigators better conceptualize and confront risks and to gain IRB approval. PMID:24173618

  6. Techniques for analyzing the impacts of certain electric-utility ratemaking and regulatory-policy concepts. Regulatory laws and policies. [State by state

    SciTech Connect

    1980-08-01

    This report is a legal study prepared to provide a review of the substantive and procedural laws of each regulatory jurisdiction that may affect implementation of the PURPA standards, and to summarize the current state of consideration and implementation of policies and rate designs similar or identical to the PURPA standards by state regulatory agencies and nonregulated utilities. This report is divided into three sections. The first section, the Introduction, summarizes the standards promulgated by PURPA and the results of the legal study. The second section, State Regulatory Law and Procedure, summarizes for each state or other ratemaking jurisdiction: (1) general constitutional and statutory provisions affecting utility rates and conditions of service; (2) specific laws or decisions affecting policy or rate design issues covered by PURPA standards; and (3) statutes and decisions governing administrative procedures, including judicial review. A chart showing actions taken on the policy and rate design issues addressed by PURPA is also included for each jurisdiction, and citations to relevant authorities are presented for each standard. State statutes or decisions that specifically define a state standard similar or identical to a PURPA standard, or that refer to one of the three PURPA objectives, are noted. The third section, Nonregulated Electric Utilities, summarizes information available on nonregulated utilities, i.e., publicly or cooperatively owned utilities which are specifically exempted from state regulation by state law.

  7. Family Issues

    MedlinePlus

    ... not mean that everyone gets along all the time. Conflicts are a part of family life. Many things can lead to conflict, such as illness, disability, addiction, job loss, school problems, and marital issues. Listening to ...

  8. Global Regulatory Pathways in the Alphaproteobacteria

    SciTech Connect

    2007-04-27

    A major goal for microbiologists in the twenty-first century is to develop an understanding of the microbial cell in all its complexity. In addition to understanding the function of individual gene products we need to focus on how the cell regulates gene expression at a global level to respond to different environmental parameters. Development of genomic technologies such as complete genome sequencing, proteomics, and global comparisons of mRNA expression patterns allows us to begin to address this issue. This proposal focuses on a number of phylogenetically related bacteria that are involved in environmentally important processes such as carbon sequestration and bioremediation. Genome sequencing projects of a number of these bacteria have revealed the presence of a small family of regulatory genes found thus far only in the alpha-proteobacteria. These genes encode proteins that are related to the global regulatory protein RosR in Rhizobium etli, which is involved in determining nodulation competitiveness in this bacterium. Our goal is to examine the function of the proteins encoded by this gene family in several of the bacteria containing homologs to RosR. We will construct gene disruption mutations in a number of these bacteria and characterize the resulting mutant strains using two-dimensional gel electrophoresis and genetic and biochemical techniques. We will thus determine if the other proteins also function as global regulators of gene expression. Using proteomics methods we will identify the specific proteins whose expression varies depending on the presence or absence of the RosR homolog. Over fifty loci regulated by RosR have been identified in R. etli using transposon mutagenesis; this will serve as out benchmark to which we will compare the other regulons. We expect to identify genes regulated by RosR homologs in several bacterial species, including, but not limited to Rhodopseudomonas palustris and Sphingomonas aromaticivorans. In this way we will

  9. Addressing problems of employee performance.

    PubMed

    McConnell, Charles R

    2011-01-01

    Employee performance problems are essentially of 2 kinds: those that are motivational in origin and those resulting from skill deficiencies. Both kinds of problems are the province of the department manager. Performance problems differ from problems of conduct in that traditional disciplinary processes ordinarily do not apply. Rather, performance problems are addressed through educational and remedial processes. The manager has a basic responsibility in ensuring that everything reasonable is done to help each employee succeed. There are a number of steps the manager can take to address employee performance problems. PMID:21537142

  10. Addressing language barriers to healthcare in India.

    PubMed

    Narayan, Lalit

    2013-01-01

    In spite of a growing recognition of the importance of doctor-patient communication, the issue of language barriers to healthcare has received very little attention in India. The Indian population speaks over 22 major languages with English used as the lingua franca for biomedicine. Large-scale internal migration has meant that health workers are encountering increasing instances of language discordance within clinical settings. Research done predominantly in the West has shown language discordance to significantly affect access to care, cause problems of comprehension and adherence, and decrease the satisfaction and quality of care. Addressing language barriers to healthcare in India requires a stronger political commitment to providing non-discriminatory health services, especially to vulnerable groups such as illiterate migrant workers. Research will have to address three broad areas: the ways in which language barriers affect health and healthcare, the efficacy of interventions to overcome language barriers, and the costs of language barriers and efforts to overcome them. There is a need to address such barriers in health worker education and clinical practice. Proven strategies such as hiring multilingual healthcare workers, providing language training to health providers, employing in situ translators or using telephone interpretation services will have to be evaluated for their appropriateness to the Indian context. Internet-based initiatives, the proliferation of mobile phones and recent advances in machine translation promise to contribute to the solution. PMID:24758452

  11. Post 9-11 Security Issues for Non-Power Reactor Facilities

    SciTech Connect

    Zaffuts, P. J.

    2003-02-25

    This paper addresses the legal and practical issues arising out of the design and implementation of a security-enhancement program for non power reactor nuclear facilities. The security enhancements discussed are derived from the commercial nuclear power industry's approach to security. The nuclear power industry's long and successful experience with protecting highly sensitive assets provides a wealth of information and lessons that should be examined by other industries contemplating security improvements, including, but not limited to facilities using or disposing of nuclear materials. This paper describes the nuclear industry's approach to security, the advantages and disadvantages of its constituent elements, and the legal issues that facilities will need to address when adopting some or all of these elements in the absence of statutory or regulatory requirements to do so.

  12. Fitness for duty in the nuclear power industry: A review of technical issues

    SciTech Connect

    Moore, C.; Barnes, V.; Hauth, J.; Wilson, R.; Fawcett-Long, J.; Toquam, J.; Baker, K.; Wieringa, D.; Olson, J.; Christensen, J.

    1989-05-01

    This report presents information gathered and analyzed in support of the US Nuclear Regulatory Commission's (NRC's) efforts to develop a rule that will ensure that workers with unescorted access to protected areas of nuclear power plants are fit for duty. This report supplements information previously published in NUREG/CR-5227, Fitness for Duty in the Nuclear Power Industry: A Review of Technical Issues (Barnes et al., 1988). The primary potential fitness-for-duty concern addressed in both of these reports is impairment caused by substance abuse, although other fitness concerns are discussed. This report addresses issues pertaining to workers' use and misuse of alcohol, prescription drugs, and over-the-counter drugs as fitness-for-duty concerns; responds to several questions raised by NRC Commissioners; discusses subversion of the chemical testing process and methods of preventing such subversion; and examines concerns about the urinalysis cutoff levels used when testing for marijuana metabolites, amphetamines, and phencyclidine (PCP).

  13. 3 CFR - Regulatory Review

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Regulatory Review Presidential Documents Other Presidential Documents Memorandum of January 30, 2009 Regulatory Review Memorandum for the Heads of Executive Departments and Agencies For well over two decades, the Office of Information and Regulatory Affairs (OIRA) at the Office of Management...

  14. Regulatory and technical reports (abstract index journal): Annual compilation for 1996, Volume 21, No. 4

    SciTech Connect

    Sheehan, M.A.

    1997-04-01

    This compilation is the annual cumulation of bibliographic data and abstracts for the formal regulatory and technical reports issued by the U.S. Nuclear Regulatory Commission (NRC) Staff and its contractors.

  15. Regulatory affairs administration as regulatory policy determinant

    SciTech Connect

    Forcier, J.R.

    1984-05-10

    It is the thesis of this article that the processing of a utility company's regulation-related work, the supporting tasks and the manner in which they are completed, can and does have a significant impact on the final results or work product of the regulatory affairs function, including even, potentially, the action of the regulatory agency. The article is therefore full of practical pointers on how the interface with the regulatory authority can best be organized, managed, and carried through to the attainment of optimum results for the utility. 2 references.

  16. Regulatory Aspects Of Implementing Electrokinetic Remediation

    EPA Science Inventory

    A better understanding of the environmental impact of hazardous waste management practices has led to new environmental laws and a comprehensive regulatory program. This program is designed to address remediation of past waste management practices and to ensure that the hazardou...

  17. 21 CFR 810.11 - Regulatory hearing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... MEDICAL DEVICE RECALL AUTHORITY Mandatory Medical Device Recall Procedures § 810.11 Regulatory hearing. (a... a recall of the device that was the subject of the order. The hearing may also address the actions that might be required by a recall order, including an appropriate recall strategy, if FDA later...

  18. 21 CFR 810.11 - Regulatory hearing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MEDICAL DEVICE RECALL AUTHORITY Mandatory Medical Device Recall Procedures § 810.11 Regulatory hearing. (a... a recall of the device that was the subject of the order. The hearing may also address the actions that might be required by a recall order, including an appropriate recall strategy, if FDA later...

  19. 21 CFR 810.11 - Regulatory hearing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... MEDICAL DEVICE RECALL AUTHORITY Mandatory Medical Device Recall Procedures § 810.11 Regulatory hearing. (a... a recall of the device that was the subject of the order. The hearing may also address the actions that might be required by a recall order, including an appropriate recall strategy, if FDA later...

  20. 21 CFR 810.11 - Regulatory hearing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... MEDICAL DEVICE RECALL AUTHORITY Mandatory Medical Device Recall Procedures § 810.11 Regulatory hearing. (a... a recall of the device that was the subject of the order. The hearing may also address the actions that might be required by a recall order, including an appropriate recall strategy, if FDA later...