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Sample records for adjust cost limits

  1. 75 FR 33379 - Railroad Cost Recovery Procedures-Productivity Adjustment; Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment; Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ] ACTION: Notice and request for...

  2. Beryllium and titanium cost-adjustment report

    NASA Astrophysics Data System (ADS)

    Owen, John; Ulph, Eric, Sr.

    1991-09-01

    This report summarizes cost adjustment factors for beryllium (Be, S200) and titanium (Ti, 6Al-4V) that were derived relative to aluminum (Al, 7075-T6). Aluminum is traditionally the material upon which many of the Cost Analysis Office, Missile Division cost estimating relationships (CERs) are based. The adjustment factors address both research and development and production (Q > 100) quantities. In addition, the factors derived include optical elements, normal structure, and structure with special requirements for minimal microcreep, such as sensor assembly parts and supporting components. Since booster cost per payload pound is an even larger factor in total missile launch costs than was initially presumed, the primary cost driver for all materials compared was the missiles' booster cost per payload pound for both R&D and production quantities. Al and Ti are 1.5 and 2.4 times more dense, respectively, than Be, and the cost to lift the heavier materials results in greater booster expense. In addition, Al and Ti must be 2.1 and 2.8, respectively, times the weight of a Be component to provide equivalent stiffness, based on the example component addressed in the report. These factors also increase booster costs. After review of the relative factors cited above, especially the lower costs for Be when stiffness and booster costs are taken into consideration, affordability becomes an important issue. When this study was initiated, both government and contractor engineers said that Be was the material to be used as a last resort because of its prohibitive cost and extreme toxicity. Although the initial price of Be may lead one to believe that any Be product would be extremely expensive, the total cost of Be used for space applications is actually competitive with or less costly than either Al or Ti. Also, the Be toxicity problem has turned out to be a non-issue for purchasers of finished Be components since no machining or grinding operations are required on the finished

  3. 76 FR 16037 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the second quarter 2011 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  4. 77 FR 37958 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the third quarter 2012 rail cost adjustment factor (RCAF) and cost index filed by the Association of...

  5. 75 FR 58019 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2010 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  6. 78 FR 17764 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the second quarter 2013 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  7. 76 FR 80448 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the first quarter 2012 rail cost adjustment factor (RCAF) and cost index filed by the Association of American Railroads....

  8. 76 FR 37191 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the third quarter 2011 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  9. 78 FR 59093 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2013 rail cost adjustment factor (RCAF) and cost index filed by the Association of...

  10. 75 FR 35877 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... TRANSPORTATION Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the third quarter 2010 rail cost adjustment factor (RCAF) and cost index filed by the Association of...

  11. 78 FR 37660 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board approves the third quarter 2013 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of American...

  12. 76 FR 59483 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2011 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  13. 78 FR 10262 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board, DOT. ACTION: Proposed railroad cost recovery procedures productivity adjustment....

  14. 77 FR 7237 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board. ACTION: Proposed railroad cost recovery procedures productivity adjustment. SUMMARY: In...

  15. 75 FR 5170 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board, DOT. ACTION: Proposed Railroad Cost Recovery Procedures Productivity Adjustment....

  16. 75 FR 16575 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board. ACTION: Adoption of a railroad cost recovery procedures productivity adjustment....

  17. 77 FR 76169 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the AAR's proposed rebasing calculations and the rebased first quarter 2013 rail cost adjustment factor (RCAF)...

  18. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not...

  19. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not...

  20. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not...

  1. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not...

  2. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not...

  3. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... limitation under section 415(b)(1), any increase in a participant's benefits associated with the limitation...)(A) dollar limit that is effective as of January 1, 2009, the associated increase in the participant... benefit plans is adjusted annually to take into account increases in the cost of living. The adjustment...

  4. 45 CFR 149.115 - Cost threshold and cost limit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Cost threshold and cost limit. 149.115 Section 149... REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Reinsurance Amounts § 149.115 Cost threshold and cost limit. The following cost threshold and cost limits apply individually, to each early retiree as...

  5. 7 CFR 701.17 - Average adjusted gross income limitation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9003), each applicant must meet the provisions of the Adjusted Gross Income Limitations at 7 CFR part... 7 Agriculture 7 2010-01-01 2010-01-01 false Average adjusted gross income limitation. 701.17... RELATED PROGRAMS PREVIOUSLY ADMINISTERED UNDER THIS PART § 701.17 Average adjusted gross income...

  6. 37 CFR 381.10 - Cost of living adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Cost of living adjustment. 381.10 Section 381.10 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS... EDUCATIONAL BROADCASTING § 381.10 Cost of living adjustment. (a) On or before December 1, 2013, the...

  7. 37 CFR 381.10 - Cost of living adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Cost of living adjustment. 381.10 Section 381.10 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS... EDUCATIONAL BROADCASTING § 381.10 Cost of living adjustment. (a) On or before December 1, 2007, the...

  8. 37 CFR 381.10 - Cost of living adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Cost of living adjustment. 381.10 Section 381.10 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS... EDUCATIONAL BROADCASTING § 381.10 Cost of living adjustment. (a) On or before December 1, 2013, the...

  9. 76 FR 74806 - Adjustment of the Amount of an Administrative Costs Assessment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... Bureau of Reclamation Adjustment of the Amount of an Administrative Costs Assessment AGENCY: Bureau of... decreasing the amount of the administrative costs assessment set forth in the Acreage Limitation Rules and... administrative costs assessment is being decreased to $230. DATES: The decrease in the amount of...

  10. 75 FR 17462 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board... information is contained in the Board's decision, which is available on our Web site...

  11. 37 CFR 253.10 - Cost of living adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... 253.10 Section 253.10 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... NONCOMMERCIAL EDUCATIONAL BROADCASTING § 253.10 Cost of living adjustment. (a) (a) On December 1, 2003, the... Register a revised schedule of rates for § 253.5 which shall adjust those royalty amounts established...

  12. 20 CFR 631.62 - Cost limitations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Cost limitations. 631.62 Section 631.62... Reserve Account Funds § 631.62 Cost limitations. The expenditure of funds provided to grantees under this subpart shall be consistent with the cost limitations specified in the grant. Applicants for grants...

  13. 48 CFR 49.303-4 - Adjustment of indirect costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Adjustment of indirect costs. 49.303-4 Section 49.303-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement...

  14. 5 CFR 838.1017 - Cost-of-living adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATIONS (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Court Orders Affecting Civil Service Retirement Benefits § 838.1017 Cost-of-living adjustments. In cases where the court order apportions a... proper payment. That amount will be increased by future cost-of-living increases unless the court...

  15. 5 CFR 838.1017 - Cost-of-living adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Court Orders Affecting Civil Service Retirement Benefits § 838.1017 Cost-of-living adjustments. In cases where the court order apportions a... proper payment. That amount will be increased by future cost-of-living increases unless the court...

  16. Adjusting Wages to Living Costs: A Historical Note

    ERIC Educational Resources Information Center

    Lowenstern, Henry

    1974-01-01

    The significant historical developments of the cost of living wage adjustments are summarized. Since the concept of cost of living took effect in 1919, developments that are noted are: World War II, the GM contract 1948, the GM Contract 1950, and the impact of the agreements. (DS)

  17. POSTURE ADJUSTMENT PROCEDURES FOR CHILDREN WHEN USING ADULT VDT WORKSTATIONS WITH LIMITED ADJUSTABILITY.

    PubMed

    Nanthavanij, Suebsak; Boon-anake, Doojchadang; Hongsiri, Kwanchanok; Miliang, Orawan

    2014-06-01

    Children are likely to assume very awkward seated postures when using a desktop computer at workstations with limited adjustability. This also includes the workstations that are not built for them such as adult visual display terminal (VDT) workstations. This paper proposes simple step-by-step procedures for estimating necessary adjustments so that children can sit and maintain an appropriate seated posture at VDT workstations with limited adjustability (i.e., fixed keyboard and monitor heights). From the anthropometric and VDT workstation data, the procedures compute the recommended VDT workstation settings for a concerned child, compare them with the actual workstation adjustment ranges, determine the appropriate settings, and suggest necessary accessories. The posture adjustment procedures are tested on four Thai children seated at two different types of adult VDT workstation. A rapid upper limb assessment (RULA) technique is used to evaluate the children's seated postures both before and after the posture adjustment. Applying the procedures, children need their own VDT workstation that should be fully adjustable. In using an adult workstation, adjustment accessories and the correct settings are required.

  18. 24 CFR 200.97 - Adjustments resulting from cost certification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Cost Certification § 200.97... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Adjustments resulting from...

  19. 24 CFR 200.97 - Adjustments resulting from cost certification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Cost Certification § 200.97... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Adjustments resulting from...

  20. 24 CFR 200.97 - Adjustments resulting from cost certification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Cost Certification § 200.97... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Adjustments resulting from...

  1. 24 CFR 200.97 - Adjustments resulting from cost certification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Cost Certification § 200.97... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Adjustments resulting from...

  2. 24 CFR 200.97 - Adjustments resulting from cost certification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Cost Certification § 200.97... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Adjustments resulting from...

  3. 77 FR 58910 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board..., which is available on our Web site, http://www.stb.dot.gov . Copies of the decision may be purchased...

  4. 77 FR 17121 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board... contained in the Board's decision, which is available on our Web site, http://www.stb.dot.gov . Copies...

  5. 75 FR 80895 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board... decision, which is available on our Web site, http://www.stb.dot.gov . Copies of the decision may...

  6. 37 CFR 253.10 - Cost of living adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Cost of living adjustment. 253.10 Section 253.10 Patents, Trademarks, and Copyrights U.S. COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES USE OF CERTAIN COPYRIGHTED WORKS IN CONNECTION...

  7. 37 CFR 253.10 - Cost of living adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Cost of living adjustment. 253.10 Section 253.10 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES USE OF CERTAIN COPYRIGHTED WORKS IN CONNECTION...

  8. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 9 2013-10-01 2013-10-01 false Cost of living adjustments of civil monetary penalties... MONETARY PENALTY INFLATION ADJUSTMENT § 506.4 Cost of living adjustments of civil monetary penalties. (a... penalty for each civil monetary penalty by the cost-of-living adjustment. Any increase determined...

  9. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 9 2014-10-01 2014-10-01 false Cost of living adjustments of civil monetary penalties... MONETARY PENALTY INFLATION ADJUSTMENT § 506.4 Cost of living adjustments of civil monetary penalties. (a... penalty for each civil monetary penalty by the cost-of-living adjustment. Any increase determined...

  10. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Cost of living adjustments of civil monetary penalties... MONETARY PENALTY INFLATION ADJUSTMENT § 506.4 Cost of living adjustments of civil monetary penalties. (a... penalty for each civil monetary penalty by the cost-of-living adjustment. Any increase determined...

  11. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 9 2011-10-01 2011-10-01 false Cost of living adjustments of civil monetary penalties... MONETARY PENALTY INFLATION ADJUSTMENT § 506.4 Cost of living adjustments of civil monetary penalties. (a... penalty for each civil monetary penalty by the cost-of-living adjustment. Any increase determined...

  12. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 9 2012-10-01 2012-10-01 false Cost of living adjustments of civil monetary penalties... MONETARY PENALTY INFLATION ADJUSTMENT § 506.4 Cost of living adjustments of civil monetary penalties. (a... penalty for each civil monetary penalty by the cost-of-living adjustment. Any increase determined...

  13. 49 CFR 1022.4 - Cost-of-living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Cost-of-living adjustments of civil monetary... PENALTY INFLATION ADJUSTMENT § 1022.4 Cost-of-living adjustments of civil monetary penalties. (a) Pursuant... determined by multiplying the Cost-of-Living Adjustment by the existing maximum civil monetary...

  14. 49 CFR 1022.4 - Cost-of-living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Cost-of-living adjustments of civil monetary... PENALTY INFLATION ADJUSTMENT § 1022.4 Cost-of-living adjustments of civil monetary penalties. (a) Pursuant... determined by multiplying the Cost-of-Living Adjustment by the existing maximum civil monetary...

  15. 78 FR 78508 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... FACTOR 100.1 98.4 \\4\\. 11 FORECAST ERROR ADJUSTMENT \\5\\ -0.026 -0.004 12 RCAF (UNADJUSTED) (LINE 10 +LINE... 1 LABOR 31.4 391.3 391.3 2 FUEL 22.6 375.6 376.0 3 MATERIALS AND SUPPLIES 5.1 264.2 264.2 4... 221.4 218.8 8 WEIGHTED AVERAGE 100.0 307.7 307.0 9 LINKED INDEX 294.4 293.1 10 RAIL COST...

  16. 76 FR 8368 - Price Index Adjustments for Contribution and Expenditure Limits and Lobbyist Bundling Disclosure...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Price Index Adjustments for Contribution and Expenditure Limits and Lobbyist Bundling Disclosure Threshold AGENCY: Federal Election Commission. ACTION: Notice of adjustments to contribution and expenditure...'' or ``the Commission'') is adjusting certain contribution and expenditure limits and the...

  17. 78 FR 8530 - Price Index Adjustments for Contribution and Expenditure Limitations and Lobbyist Bundling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Price Index Adjustments for Contribution and Expenditure Limitations and Lobbyist Bundling Disclosure Threshold AGENCY: Federal Election Commission. ACTION: Notice of adjustments to contribution and expenditure...'' or ``the Commission'') is adjusting certain contribution and expenditure limitations and the...

  18. 24 CFR 401.412 - Adjustment of rents based on operating cost adjustment factor (OCAF) or budget.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... operating cost adjustment factor (OCAF) or budget. 401.412 Section 401.412 Housing and Urban Development... of rents based on operating cost adjustment factor (OCAF) or budget. (a) OCAF. (1) The Restructuring... contracts in subsequent years which receive restructured rents under either section 514(g)(1) or (2)...

  19. 20 CFR 631.62 - Cost limitations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Cost limitations. 631.62 Section 631.62 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROGRAMS UNDER TITLE III OF THE JOB TRAINING PARTNERSHIP ACT Federal Delivery of Dislocated Worker Services Through...

  20. 42 CFR 417.588 - Computation of adjusted average per capita cost (AAPCC).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Computation of adjusted average per capita cost... of adjusted average per capita cost (AAPCC). (a) Basic data. In computing the AAPCC, CMS uses the U.S. per capita incurred cost and adjusts it by the factors specified in paragraph (c) of this section...

  1. 42 CFR 417.588 - Computation of adjusted average per capita cost (AAPCC).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Computation of adjusted average per capita cost... of adjusted average per capita cost (AAPCC). (a) Basic data. In computing the AAPCC, CMS uses the U.S. per capita incurred cost and adjusts it by the factors specified in paragraph (c) of this section...

  2. 42 CFR 417.588 - Computation of adjusted average per capita cost (AAPCC).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Computation of adjusted average per capita cost... adjusted average per capita cost (AAPCC). (a) Basic data. In computing the AAPCC, CMS uses the U.S. per capita incurred cost and adjusts it by the factors specified in paragraph (c) of this section...

  3. 42 CFR 417.588 - Computation of adjusted average per capita cost (AAPCC).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Computation of adjusted average per capita cost... of adjusted average per capita cost (AAPCC). (a) Basic data. In computing the AAPCC, CMS uses the U.S. per capita incurred cost and adjusts it by the factors specified in paragraph (c) of this section...

  4. Innovative Feed-In Tariff Designs that Limit Policy Costs

    SciTech Connect

    Kreycik, C.; Couture, T. D.; Cory, K. S.

    2011-06-01

    Feed-in tariffs (FITs) are the most prevalent renewable energy policy used globally to date, and there are many benefits to the certainty offered in the marketplace to reduce development risks and associated financing costs and to grow the renewable energy industry. However, concerns over escalating costs in jurisdictions with FIT policies have led to increased attention on cost control in renewable energy policy design. In recent years, policy mechanisms for containing FIT costs have become more refined, allowing policymakers to exert greater control on policy outcomes and on the resulting costs to ratepayers. As policymakers and regulators in the United States begin to explore the use of FITs, careful consideration must be given to the ways in which policy design can be used to balance the policies' advantages while bounding its costs. This report explores mechanisms that policymakers have implemented to limit FIT policy costs. If designed clearly and transparently, such mechanisms can align policymaker and market expectations for project deployment. Three different policy tools are evaluated: (1) caps, (2) payment level adjustment mechanisms, and (3) auction-based designs. The report employs case studies to explore the strengths and weaknesses of these three cost containment tools. These tools are then evaluated with a set of criteria including predictability for policymakers and the marketplace and the potential for unintended consequences.

  5. 48 CFR 9904.413 - Adjustment and allocation of pension cost.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Adjustment and allocation of pension cost. 9904.413 Section 9904.413 Federal Acquisition Regulations System COST ACCOUNTING... AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.413 Adjustment and allocation of...

  6. 76 FR 6148 - Notice of Adjustment of Statewide Per Capita Indicator for Recommending a Cost Share Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... SECURITY Federal Emergency Management Agency Notice of Adjustment of Statewide Per Capita Indicator for...: FEMA gives notice that the statewide per capita indicator for recommending cost share adjustments for... declared on January 1, 2011, through December 31, 2011, the qualifying indicator is $127 per capita...

  7. 77 FR 5262 - Notice of Adjustment of Statewide Per Capita Indicator for Recommending a Cost Share Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... SECURITY Federal Emergency Management Agency Notice of Adjustment of Statewide Per Capita Indicator for...: FEMA gives notice that the statewide per capita indicator for recommending cost share adjustments for... 20472, (202) 646-3834. SUPPLEMENTARY INFORMATION: Pursuant to 44 CFR 206.47, the statewide per...

  8. 78 FR 9935 - Notice of Adjustment of Statewide Per Capita Indicator for Recommending a Cost Share Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... SECURITY Federal Emergency Management Agency Notice of Adjustment of Statewide Per Capita Indicator for...: FEMA gives notice that the statewide per capita indicator for recommending cost share adjustments for... 20472, (202) 646-3834. SUPPLEMENTARY INFORMATION: Pursuant to 44 CFR 206.47, the statewide per...

  9. 75 FR 4578 - Notice of Adjustment of Statewide Per Capita Threshold for Recommending a Cost Share Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... SECURITY Federal Emergency Management Agency Notice of Adjustment of Statewide Per Capita Threshold for...: FEMA gives notice that the statewide per capita threshold for recommending cost share adjustments for... declared on January 1, 2010, through December 31, 2010, the qualifying threshold is $125 per capita...

  10. Careful telemedicine planning limits costly liability exposure.

    PubMed

    Edelstein, S A

    1999-12-01

    Recent Federal and state legislation and new payment opportunities from Medicare, Medicaid, and private payers may make it possible to offer telemedicine as a viable, cost-effective alternative to traditional care delivery in communities where access to health care is limited. Originally, nonexistent payment and expensive technology held back telemedicine but, these barriers are giving way to specific applications that can yield dramatic cost savings for group practices in the delivery of medical care while adding features and benefits not typically available in traditional delivery settings. Before joining a telemedicine network, group practices need to negotiate a variety of legal issues related to the corporate practice of medicine, patient confidentiality and privacy, malpractice, informed consent, licensure and credentialing, intellectual property, Medicare and Medicaid payment, fraud and abuse, medical device regulation, and antitrust.

  11. 14 CFR 13.305 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Inflation Adjustment § 13.305 Cost of living adjustments of civil monetary penalties. (a) Except for the... and maximum civil monetary penalty for each civil monetary penalty by the cost-of-living adjustment... penalties greater than $200,000. (b) For purposes of paragraph (a) of this section, the term...

  12. 14 CFR 13.305 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Inflation Adjustment § 13.305 Cost of living adjustments of civil monetary penalties. (a) Except for the... and maximum civil monetary penalty for each civil monetary penalty by the cost-of-living adjustment... penalties greater than $200,000. (b) For purposes of paragraph (a) of this section, the term...

  13. 14 CFR 13.305 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Inflation Adjustment § 13.305 Cost of living adjustments of civil monetary penalties. (a) Except for the... and maximum civil monetary penalty for each civil monetary penalty by the cost-of-living adjustment... penalties greater than $200,000. (b) For purposes of paragraph (a) of this section, the term...

  14. 14 CFR 13.305 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Inflation Adjustment § 13.305 Cost of living adjustments of civil monetary penalties. (a) Except for the... and maximum civil monetary penalty for each civil monetary penalty by the cost-of-living adjustment... penalties greater than $200,000. (b) For purposes of paragraph (a) of this section, the term...

  15. 14 CFR 13.305 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Inflation Adjustment § 13.305 Cost of living adjustments of civil monetary penalties. (a) Except for the... and maximum civil monetary penalty for each civil monetary penalty by the cost-of-living adjustment... penalties greater than $200,000. (b) For purposes of paragraph (a) of this section, the term...

  16. 24 CFR 1000.320 - How is Formula Current Assisted Stock adjusted for local area costs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... § 1000.320 How is Formula Current Assisted Stock adjusted for local area costs? There are two adjustment... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false How is Formula Current Assisted Stock adjusted for local area costs? 1000.320 Section 1000.320 Housing and Urban Development...

  17. 48 CFR 252.236-7006 - Cost limitation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Cost limitation. 252.236... Clauses 252.236-7006 Cost limitation. As prescribed in 236.570(b)(4), use the following provision: Cost Limitation (JAN 1997) (a) Certain items in this solicitation are subject to statutory cost limitations....

  18. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... NASA's initial cost share or funding levels, detailed cost analysis techniques may be applied, which... (cash and/or in-kind contributions) by NASA and the recipient beyond the initial agreement may be needed. There may also be occasions where actual costs of NASA and the recipient may be less than...

  19. 48 CFR 49.303-4 - Adjustment of indirect costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... costs. 49.303-4 Section 49.303-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts... compute indirect costs for other contracts performed during the applicable accounting period....

  20. 48 CFR 49.303-4 - Adjustment of indirect costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... costs. 49.303-4 Section 49.303-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts... compute indirect costs for other contracts performed during the applicable accounting period....

  1. 48 CFR 49.303-4 - Adjustment of indirect costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... costs. 49.303-4 Section 49.303-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts... compute indirect costs for other contracts performed during the applicable accounting period....

  2. 14 CFR § 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... modification increasing NASA's initial cost share or funding levels, detailed cost analysis techniques may be... contributions (cash and/or in-kind contributions) by NASA and the recipient beyond the initial agreement may be needed. There may also be occasions where actual costs of NASA and the recipient may be less...

  3. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... NASA's initial cost share or funding levels, detailed cost analysis techniques may be applied, which... (cash and/or in-kind contributions) by NASA and the recipient beyond the initial agreement may be needed. There may also be occasions where actual costs of NASA and the recipient may be less than...

  4. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... NASA's initial cost share or funding levels, detailed cost analysis techniques may be applied, which... (cash and/or in-kind contributions) by NASA and the recipient beyond the initial agreement may be needed. There may also be occasions where actual costs of NASA and the recipient may be less than...

  5. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NASA's initial cost share or funding levels, detailed cost analysis techniques may be applied, which... (cash and/or in-kind contributions) by NASA and the recipient beyond the initial agreement may be needed. There may also be occasions where actual costs of NASA and the recipient may be less than...

  6. 78 FR 71501 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... the section 119 compulsory license for the 2010-2014 term. See 75 FR 53198. The rates adopted by the... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... Copyright Royalty Judges announce a cost of living adjustment (COLA) of 1% in the royalty rates...

  7. 32 CFR 269.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Cost of living adjustments of civil monetary... DEFENSE (CONTINUED) MISCELLANEOUS CIVIL MONETARY PENALTY INFLATION ADJUSTMENT § 269.4 Cost of living... increasing the maximum civil monetary penalty for each civil monetary penalty by the...

  8. 32 CFR 269.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Cost of living adjustments of civil monetary... DEFENSE (CONTINUED) MISCELLANEOUS CIVIL MONETARY PENALTY INFLATION ADJUSTMENT § 269.4 Cost of living... increasing the maximum civil monetary penalty for each civil monetary penalty by the...

  9. 32 CFR 269.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Cost of living adjustments of civil monetary... DEFENSE (CONTINUED) MISCELLANEOUS CIVIL MONETARY PENALTY INFLATION ADJUSTMENT § 269.4 Cost of living... increasing the maximum civil monetary penalty for each civil monetary penalty by the...

  10. 32 CFR 269.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Cost of living adjustments of civil monetary... DEFENSE (CONTINUED) MISCELLANEOUS CIVIL MONETARY PENALTY INFLATION ADJUSTMENT § 269.4 Cost of living... increasing the maximum civil monetary penalty for each civil monetary penalty by the...

  11. 10 CFR 950.26 - Adjustments to claim for payment of covered costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Adjustments to claim for payment of covered costs. 950.26 Section 950.26 Energy DEPARTMENT OF ENERGY STANDBY SUPPORT FOR CERTAIN NUCLEAR PLANT DELAYS Claims Administration Process § 950.26 Adjustments to claim for payment of covered costs. (a) Aggregate amount...

  12. 42 CFR 417.588 - Computation of adjusted average per capita cost (AAPCC).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Computation of adjusted average per capita cost (AAPCC). 417.588 Section 417.588 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... adjusted average per capita cost (AAPCC). (a) Basic data. In computing the AAPCC, CMS uses the U.S....

  13. An Introduction to Cost-of-Living Adjustments in Public Retirement Plans: Details Matter

    ERIC Educational Resources Information Center

    Jennings, Penelope R.; Jennings, William P.; Phillips, G. Michael

    2016-01-01

    While financial planning students are expected to be able to understand client retirement plans, subtle differences in cost-of-living adjustments can have major impact on the success of client retirement plans. This teaching note compares the cost-of-living adjustments in the largest government sponsored retirement systems and a hypothetical…

  14. 48 CFR 9904.413 - Adjustment and allocation of pension cost.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of pension cost. 9904.413 Section 9904.413 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.413 Adjustment and allocation of...

  15. 48 CFR 9904.413 - Adjustment and allocation of pension cost.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of pension cost. 9904.413 Section 9904.413 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.413 Adjustment and allocation of...

  16. 48 CFR 9904.413 - Adjustment and allocation of pension cost.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of pension cost. 9904.413 Section 9904.413 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.413 Adjustment and allocation of...

  17. 44 CFR 206.47 - Cost-share adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... effective for disasters declared on or after May 21, 1999, $75 per capita of State population; (2) Effective... population; (3) Effective for disasters declared after January 1, 2001, $100 per capita of State population... of State population, adjusted annually for inflation using the Consumer Price Index for All...

  18. 44 CFR 206.47 - Cost-share adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... effective for disasters declared on or after May 21, 1999, $75 per capita of State population; (2) Effective... population; (3) Effective for disasters declared after January 1, 2001, $100 per capita of State population... of State population, adjusted annually for inflation using the Consumer Price Index for All...

  19. A Primer for Making Cost Adjustments in Education.

    ERIC Educational Resources Information Center

    Fowler, William J., Jr.; Monk, David H.

    2001-01-01

    Attempts to explain the differences between education costs and expenditures and explains the differences in the "unit price" of teachers in different regions and differences over time in the level of inflation. Also examines indices that can be used to make judgments about the differences in costs and outlines a plan to derive an index for school…

  20. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., subject to validation by the intermediary, will estimate the current cost of the service to which a limit... when there is no second preceding period) exceed the current cost limits. (Data from the most recently... 42 Public Health 2 2010-10-01 2010-10-01 false Limitations on coverage of costs: Charges...

  1. Optimal management of a stochastically varying population when policy adjustment is costly.

    PubMed

    Boettiger, Carl; Bode, Michael; Sanchirico, James N; Lariviere, Jacob; Hastings, Alan; Armsworth, Paul R

    2016-04-01

    Ecological systems are dynamic and policies to manage them need to respond to that variation. However, policy adjustments will sometimes be costly, which means that fine-tuning a policy to track variability in the environment very tightly will only sometimes be worthwhile. We use a classic fisheries management problem, how to manage a stochastically varying population using annually varying quotas in order to maximize profit, to examine how costs of policy adjustment change optimal management recommendations. Costs of policy adjustment (changes in fishing quotas through time) could take different forms. For example, these costs may respond to the size of the change being implemented, or there could be a fixed cost any time a quota change is made. We show how different forms of policy costs have contrasting implications for optimal policies. Though it is frequently assumed that costs to adjusting policies will dampen variation in the policy, we show that certain cost structures can actually increase variation through time. We further show that failing to account for adjustment costs has a consistently worse economic impact than would assuming these costs are present when they are not. PMID:27411252

  2. Adjustable direct current and pulsed circuit fault current limiter

    DOEpatents

    Boenig, Heinrich J.; Schillig, Josef B.

    2003-09-23

    A fault current limiting system for direct current circuits and for pulsed power circuit. In the circuits, a current source biases a diode that is in series with the circuits' transmission line. If fault current in a circuit exceeds current from the current source biasing the diode open, the diode will cease conducting and route the fault current through the current source and an inductor. This limits the rate of rise and the peak value of the fault current.

  3. 78 FR 21712 - Compensation Cost-of-Living Adjustments for Service-Connected Benefits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... AFFAIRS Compensation Cost-of-Living Adjustments for Service-Connected Benefits AGENCY: Department of Veterans Affairs. ACTION: Notice. SUMMARY: As required by the Veterans' Compensation Cost-of-Living... Security Administration has announced that there will be a 1.7 percent cost-of-living increase in...

  4. 25 CFR 137.5 - Construction costs limited.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Construction costs limited. 137.5 Section 137.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES REIMBURSEMENT OF CONSTRUCTION COSTS, SAN CARLOS INDIAN IRRIGATION PROJECT, ARIZONA § 137.5 Construction costs limited. The...

  5. 25 CFR 137.5 - Construction costs limited.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Construction costs limited. 137.5 Section 137.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES REIMBURSEMENT OF CONSTRUCTION COSTS, SAN CARLOS INDIAN IRRIGATION PROJECT, ARIZONA § 137.5 Construction costs limited. The...

  6. 25 CFR 137.5 - Construction costs limited.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Construction costs limited. 137.5 Section 137.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES REIMBURSEMENT OF CONSTRUCTION COSTS, SAN CARLOS INDIAN IRRIGATION PROJECT, ARIZONA § 137.5 Construction costs limited. The...

  7. 25 CFR 137.5 - Construction costs limited.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Construction costs limited. 137.5 Section 137.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES REIMBURSEMENT OF CONSTRUCTION COSTS, SAN CARLOS INDIAN IRRIGATION PROJECT, ARIZONA § 137.5 Construction costs limited. The...

  8. 20 CFR 627.445 - Limitations on certain costs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... title II-C programs. (3) The title II-B administrative cost limitation of 15 percent shall be 15 percent... (a) and (b) of this section (section 161(b)). (d) Administrative costs incurred by a community-based... shall establish a system to regularly assess compliance with the cost limitations including...

  9. Innovative Feed-In Tariff Designs that Limit Policy Costs

    SciTech Connect

    Kreycik, Claire; Couture, Toby D.; Cory, Karlynn S.

    2011-06-01

    Feed-in tariffs (FITs) are the most prevalent policy used globally to reduce development risks, cut financing costs, and grow the renewable energy industry. However, concerns over escalating costs in jurisdictions with FIT policies have led to increased attention on cost control. Using case studies and market-focused analysis, this report from the National Renewable Energy Laboratory (NREL) examines strengths and weaknesses of three cost-containment tools: (1) caps, (2) payment level adjustment mechanisms, and (3) auction-based designs. The report provides useful insights on containing costs for policymakers and regulators in the United States and other areas where FIT policies are in development.

  10. 78 FR 49945 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... prohibition to apply to geophysical exploration permits. 70 FR 58854--58855. While the $25 fees for.... 1734. In 2005, the BLM published a final cost recovery rule (70 FR 58854) establishing or revising... published September 10, 2012 (77 FR 55420), effective October 1, 2012. \\2\\ The Existing Value is the...

  11. 75 FR 55678 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... exploration permits. 70 FR 58854--58855. While the $25 fees for geophysical exploration permit applications... Management Act of 1976 (FLPMA), 43 U.S.C. 1734. In 2005, the BLM published a final cost recovery rule (70 FR... update rule became effective on October 1, 2009, 74 FR 49330 (Sept. 28, 2009), based on the IPD-GDP...

  12. 2 CFR 200.411 - Adjustment of previously negotiated indirect (F&A) cost rates containing unallowable costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Adjustment of previously negotiated indirect (F&A) cost rates containing unallowable costs. 200.411 Section 200.411 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GUIDANCE Reserved UNIFORM ADMINISTRATIVE...

  13. 78 FR 23902 - Retail Exemptions Adjusted Dollar Limitations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ...) is announcing the dollar limitations on the amount of meat and meat food products, poultry, and poultry products that a retail store can sell to hotels, restaurants, and similar institutions without... $67,300 to $69,600 and for poultry products from $51,700 to $54,500. FSIS is changing the...

  14. 77 FR 55420 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ... Management Act of 1976 (FLPMA), 43 U.S.C. 1734. In 2005, the BLM published a final cost recovery rule (70 FR... Implicit Price Deflator for Gross Domestic Product (IPD-GDP), which is published quarterly by the U.S... are based on the change in the IPD-GDP from the 4th Quarter of one calendar year to the 4th Quarter...

  15. 76 FR 59058 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Management Act of 1976 (FLPMA), 43 U.S.C. 1734. In 2005, the BLM published a final cost recovery rule (70 FR... Implicit Price Deflator for Gross Domestic Product (IPD-GDP), which is published quarterly by the U.S... are based on the change in the IPD-GDP from the 4th Quarter of one calendar year to the 4th Quarter...

  16. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services. 413.35 Section 413.35 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR...

  17. 75 FR 75624 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... FR 53198 (August 31, 2010). Section 119(c)(2) requires the Judges annually to adjust these rates ``to... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... by satellite carriers under the satellite carrier compulsory license of the Copyright Act. The...

  18. Adjusting Teacher Salaries for the Cost of Living: The Effect on Salary Comparisons and Policy Conclusions

    ERIC Educational Resources Information Center

    Stoddard, C.

    2005-01-01

    Teaching salaries are commonly adjusted for the cost of living, but this incorrectly accounts for welfare differences across states. Adjusting for area amenities and opportunities, however, produces more accurate salary comparisons. Amenities and opportunities can be measured by the wage premium other workers in a state face. The two methods…

  19. 32 CFR 3.6 - Limitations on cost-sharing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... THAN CONTRACTS, GRANTS, OR COOPERATIVE AGREEMENTS FOR PROTOTYPE PROJECTS § 3.6 Limitations on cost... prototype project and cost-sharing is the reason for using OT authority, then the non-Federal amounts... the OT agreement becomes effective. Costs that were incurred for a prototype project by the...

  20. 32 CFR 3.6 - Limitations on cost-sharing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... THAN CONTRACTS, GRANTS, OR COOPERATIVE AGREEMENTS FOR PROTOTYPE PROJECTS § 3.6 Limitations on cost... prototype project and cost-sharing is the reason for using OT authority, then the non-Federal amounts... the OT agreement becomes effective. Costs that were incurred for a prototype project by the...

  1. 32 CFR 3.6 - Limitations on cost-sharing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... THAN CONTRACTS, GRANTS, OR COOPERATIVE AGREEMENTS FOR PROTOTYPE PROJECTS § 3.6 Limitations on cost... prototype project and cost-sharing is the reason for using OT authority, then the non-Federal amounts... the OT agreement becomes effective. Costs that were incurred for a prototype project by the...

  2. 32 CFR 3.6 - Limitations on cost-sharing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THAN CONTRACTS, GRANTS, OR COOPERATIVE AGREEMENTS FOR PROTOTYPE PROJECTS § 3.6 Limitations on cost... prototype project and cost-sharing is the reason for using OT authority, then the non-Federal amounts... the OT agreement becomes effective. Costs that were incurred for a prototype project by the...

  3. 10 CFR 605.16 - Indirect cost limitations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Indirect cost limitations. 605.16 Section 605.16 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM § 605.16 Indirect cost limitations. Awards issued under this part for conferences and...

  4. 10 CFR 605.16 - Indirect cost limitations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Indirect cost limitations. 605.16 Section 605.16 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM § 605.16 Indirect cost limitations. Awards issued under this part for conferences and...

  5. 10 CFR 605.16 - Indirect cost limitations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Indirect cost limitations. 605.16 Section 605.16 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM § 605.16 Indirect cost limitations. Awards issued under this part for conferences and...

  6. 10 CFR 605.16 - Indirect cost limitations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Indirect cost limitations. 605.16 Section 605.16 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM § 605.16 Indirect cost limitations. Awards issued under this part for conferences and...

  7. 48 CFR 3432.704 - Limitation of cost or funds.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Limitation of cost or funds. 3432.704 Section 3432.704 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION... Limitation of cost or funds. (a) Under the circumstances in FAR 32.704(a)(1), the contractor shall submit...

  8. 10 CFR 602.15 - Indirect cost limitations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Indirect cost limitations. 602.15 Section 602.15 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.15 Indirect cost limitations. Awards issued under this part for conferences...

  9. 33 CFR 138.240 - Procedure for calculating limit of liability adjustments for inflation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (d) 33 CFR Ch. I (7-1-10 Edition) Coast Guard, DHS ... of liability adjustments for inflation. 138.240 Section 138.240 Navigation and Navigable Waters COAST... calculating limit of liability adjustments for inflation. (a) Formula for calculating a cumulative...

  10. 33 CFR 138.240 - Procedure for calculating limit of liability adjustments for inflation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (d) 33 CFR Ch. I (7-1-11 Edition) Coast Guard, DHS ... of liability adjustments for inflation. 138.240 Section 138.240 Navigation and Navigable Waters COAST... calculating limit of liability adjustments for inflation. (a) Formula for calculating a cumulative...

  11. 33 CFR 138.240 - Procedure for calculating limit of liability adjustments for inflation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... (d) 33 CFR Ch. I (7-1-12 Edition) Coast Guard, DHS ... of liability adjustments for inflation. 138.240 Section 138.240 Navigation and Navigable Waters COAST... calculating limit of liability adjustments for inflation. (a) Formula for calculating a cumulative...

  12. 33 CFR 138.240 - Procedure for calculating limit of liability adjustments for inflation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... (d) 33 CFR Ch. I (7-1-14 Edition) Coast Guard, DHS ... of liability adjustments for inflation. 138.240 Section 138.240 Navigation and Navigable Waters COAST... calculating limit of liability adjustments for inflation. (a) Formula for calculating a cumulative...

  13. 33 CFR 138.240 - Procedure for calculating limit of liability adjustments for inflation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (d) 33 CFR Ch. I (7-1-13 Edition) Coast Guard, DHS ... of liability adjustments for inflation. 138.240 Section 138.240 Navigation and Navigable Waters COAST... calculating limit of liability adjustments for inflation. (a) Formula for calculating a cumulative...

  14. 77 FR 9925 - Price Index Adjustments for Expenditure Limitations and Lobbyist Bundling Disclosure Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION...: Federal Election Commission. ACTION: Notice of adjustments to expenditure limitations and lobbyist bundling disclosure threshold. SUMMARY: As mandated by provisions of the Federal Election Campaign Act...

  15. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...(v)(1)(A) of the Act by setting forth the general rules under which CMS may establish limits on SNF... characteristics of the SNF or HHA class, the data on which CMS bases those limits, or the method by which CMS... July 1, 1998, a SNF may request an exception or exemption to the cost limits imposed under this...

  16. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...(v)(1)(A) of the Act by setting forth the general rules under which CMS may establish limits on SNF... characteristics of the SNF or HHA class, the data on which CMS bases those limits, or the method by which CMS... July 1, 1998, a SNF may request an exception or exemption to the cost limits imposed under this...

  17. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...(v)(1)(A) of the Act by setting forth the general rules under which CMS may establish limits on SNF... characteristics of the SNF or HHA class, the data on which CMS bases those limits, or the method by which CMS... July 1, 1998, a SNF may request an exception or exemption to the cost limits imposed under this...

  18. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...(v)(1)(A) of the Act by setting forth the general rules under which CMS may establish limits on SNF... characteristics of the SNF or HHA class, the data on which CMS bases those limits, or the method by which CMS... July 1, 1998, a SNF may request an exception or exemption to the cost limits imposed under this...

  19. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...(v)(1)(A) of the Act by setting forth the general rules under which CMS may establish limits on SNF... characteristics of the SNF or HHA class, the data on which CMS bases those limits, or the method by which CMS... July 1, 1998, a SNF may request an exception or exemption to the cost limits imposed under this...

  20. 24 CFR 248.123 - Determination of Federal cost limit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Determination of Federal cost limit... AUTHORITIES PREPAYMENT OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of 1990 § 248.123 Determination of Federal cost...

  1. 24 CFR 248.123 - Determination of Federal cost limit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Determination of Federal cost limit... AUTHORITIES PREPAYMENT OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of 1990 § 248.123 Determination of Federal cost...

  2. 44 CFR 208.66 - Reopening of claims for retrospective or retroactive adjustment of costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reopening of claims for retrospective or retroactive adjustment of costs. 208.66 Section 208.66 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN SEARCH AND RESCUE RESPONSE...

  3. 77 FR 70373 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ...\\ yielded no objections. See 75 FR 53198 (August 31, 2010). Section 119(c)(2) requires the Judges annually... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... by satellite carriers under the satellite carrier compulsory license of the Copyright Act. The...

  4. 76 FR 74703 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ...\\ yielded no objections. See 75 FR 53198 (August 31, 2010). Section 119(c)(2) requires the Judges annually... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... by satellite carriers under the satellite carrier compulsory license of the Copyright Act. The...

  5. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Cost-of-living adjustments. 1.415(d)-1 Section 1.415(d)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.415(d)-1...

  6. 24 CFR 1000.325 - How is the need component adjusted for local area costs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Allocation Formula § 1000.325... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false How is the need component adjusted for local area costs? 1000.325 Section 1000.325 Housing and Urban Development Regulations Relating...

  7. 24 CFR 1000.325 - How is the need component adjusted for local area costs?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Allocation Formula § 1000.325... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false How is the need component adjusted for local area costs? 1000.325 Section 1000.325 Housing and Urban Development REGULATIONS RELATING...

  8. 24 CFR 1000.325 - How is the need component adjusted for local area costs?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Allocation Formula § 1000.325... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false How is the need component adjusted for local area costs? 1000.325 Section 1000.325 Housing and Urban Development REGULATIONS RELATING...

  9. 78 FR 71501 - Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ...-2017. See 77 FR 71104. Pursuant to these regulations, on or before December 1 of each year, the Judges... Copyright Royalty Board 37 CFR Part 381 Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Final rule....

  10. 45 CFR 63.18 - Limitations on costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Limitations on costs. 63.18 Section 63.18 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GRANT PROGRAMS ADMINISTERED BY THE OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Financial Provisions § 63.18 Limitations...

  11. High cost pool or high cost groups-How to handle high(est) cost cases in a risk adjustment mechanism?

    PubMed

    Schillo, Sonja; Lux, Gerald; Wasem, Juergen; Buchner, Florian

    2016-02-01

    Competitive social health insurance systems (at least) in Western Europe have implemented systems of morbidity based risk adjustment to set a level playing field for insurers. However, many high cost insured still are heavily underfunded despite risk adjustment, leaving incentives for risk selection. In most of these health care systems, there is an ongoing debate about how to deal with such underpaid high cost cases. This study develops four distinct concepts by adding variables to risk adjustment or by setting up a high cost pool for underpaid insured besides the risk adjustment system. Their features, incentives and distributional effects are discussed. With a data set of 6 million insured, performance is demonstrated for Germany. All models achieve a substantial improvement in model fit, measured in terms of R(2) as well as CPM. As the results of the various models are different in different dimensions, the trade-offs that have to be dealt with and should be addressed, when implementing a model to reduce underfunding of high cost cases. PMID:26806676

  12. High cost pool or high cost groups-How to handle high(est) cost cases in a risk adjustment mechanism?

    PubMed

    Schillo, Sonja; Lux, Gerald; Wasem, Juergen; Buchner, Florian

    2016-02-01

    Competitive social health insurance systems (at least) in Western Europe have implemented systems of morbidity based risk adjustment to set a level playing field for insurers. However, many high cost insured still are heavily underfunded despite risk adjustment, leaving incentives for risk selection. In most of these health care systems, there is an ongoing debate about how to deal with such underpaid high cost cases. This study develops four distinct concepts by adding variables to risk adjustment or by setting up a high cost pool for underpaid insured besides the risk adjustment system. Their features, incentives and distributional effects are discussed. With a data set of 6 million insured, performance is demonstrated for Germany. All models achieve a substantial improvement in model fit, measured in terms of R(2) as well as CPM. As the results of the various models are different in different dimensions, the trade-offs that have to be dealt with and should be addressed, when implementing a model to reduce underfunding of high cost cases.

  13. 32 CFR 644.521 - Limitations on clearance cost.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Limitations on clearance cost. 644.521 Section 644.521 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Clearance of Explosive Hazards and Other Contamination from...

  14. 24 CFR 891.853 - Development cost limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Development cost limits. 891.853 Section 891.853 Housing and Urban Development Regulations Relating to Housing and Urban Development... AND URBAN DEVELOPMENT (SECTION 8 HOUSING ASSISTANCE PROGRAMS, SECTION 202 DIRECT LOAN PROGRAM,...

  15. 32 CFR 644.521 - Limitations on clearance cost.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Limitations on clearance cost. 644.521 Section 644.521 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Clearance of Explosive Hazards and Other Contamination from...

  16. 32 CFR 644.521 - Limitations on clearance cost.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Limitations on clearance cost. 644.521 Section 644.521 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Clearance of Explosive Hazards and Other Contamination from...

  17. 32 CFR 644.521 - Limitations on clearance cost.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Limitations on clearance cost. 644.521 Section 644.521 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Clearance of Explosive Hazards and Other Contamination from...

  18. 32 CFR 644.521 - Limitations on clearance cost.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Limitations on clearance cost. 644.521 Section 644.521 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Clearance of Explosive Hazards and Other Contamination from...

  19. Processing speed and mental retardation: deadline procedures indicate fixed and adjustable limitations.

    PubMed

    Brewer, N; Smith, G A

    1990-09-01

    Brewer and Smith (1984) showed that control mechanisms mediating speed-accuracy regulation contribute to retarded-nonretarded differences in processing speed, with poorly controlled trial-to-trial RT adjustments underlying the greater RT variability of retarded individuals. In Experiment 1, response deadlines controlled processing time, thus minimizing the influence of such control mechanisms. The obtained speed-accuracy relations showed that retarded subjects were unable to match nonretarded subjects' accuracy when responding as rapidly, thus indicating structural limitations on processing speed. The results of Experiment 2 showed, however, that significant adjustments to retarded subjects' processing speed--exceeding those produced by practice--are achievable. Extended training at a short deadline led to tighter control of RT adjustments, with substantial improvements in mean RT when subjects transferred to a self-paced RT task. PMID:2233257

  20. Dynamic probability control limits for risk-adjusted Bernoulli CUSUM charts.

    PubMed

    Zhang, Xiang; Woodall, William H

    2015-11-10

    The risk-adjusted Bernoulli cumulative sum (CUSUM) chart developed by Steiner et al. (2000) is an increasingly popular tool for monitoring clinical and surgical performance. In practice, however, the use of a fixed control limit for the chart leads to a quite variable in-control average run length performance for patient populations with different risk score distributions. To overcome this problem, we determine simulation-based dynamic probability control limits (DPCLs) patient-by-patient for the risk-adjusted Bernoulli CUSUM charts. By maintaining the probability of a false alarm at a constant level conditional on no false alarm for previous observations, our risk-adjusted CUSUM charts with DPCLs have consistent in-control performance at the desired level with approximately geometrically distributed run lengths. Our simulation results demonstrate that our method does not rely on any information or assumptions about the patients' risk distributions. The use of DPCLs for risk-adjusted Bernoulli CUSUM charts allows each chart to be designed for the corresponding particular sequence of patients for a surgeon or hospital.

  1. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  2. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  3. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  4. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  5. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  6. Time limitation, egg limitation, the cost of oviposition, and lifetime reproduction by an insect in nature.

    PubMed

    Rosenheim, Jay A; Jepsen, Sarina J; Matthews, Christopher E; Smith, D Solance; Rosenheim, Micah R

    2008-10-01

    For more than 80 years, ecologists have debated whether reproduction by female insect herbivores and parasitoids is constrained by the time needed to find hosts (time limitation) or by the finite supply of mature eggs (egg limitation). Here we present the first direct measures of permanent time limitation and egg limitation and their influences on the cost of oviposition and lifetime reproduction for an insect in nature. We studied the gall midge Rhopalomyia californica, which neither matures nor resorbs eggs during the adult stage. By sampling females soon after their death and correcting for predation effects, we demonstrate that females lay a large proportion of their total complement of eggs (multiyear mean: 82.9%). The egg supplies of 17.1% of females were completely exhausted, with the remaining 82.9% of females being time limited. As predicted by theory, we estimate that even though egg limitation is a minority condition within the population, egg costs make a substantial contribution (57% of the total) to the cost of oviposition. We conclude that insect life histories evolve to produce a balanced risk of time and egg limitation and, therefore, that both of these constraining factors have important influences on insect oviposition behavior and population dynamics.

  7. Traumatic Brain Injury in the Netherlands: Incidence, Costs and Disability-Adjusted Life Years

    PubMed Central

    Scholten, Annemieke C.; Haagsma, Juanita A.; Panneman, Martien J. M.; van Beeck, Ed F.; Polinder, Suzanne

    2014-01-01

    Objective Traumatic brain injury (TBI) is a major cause of death and disability, leading to great personal suffering and huge costs to society. Integrated knowledge on epidemiology, economic consequences and disease burden of TBI is scarce but essential for optimizing healthcare policy and preventing TBI. This study aimed to estimate incidence, cost-of-illness and disability-adjusted life years (DALYs) of TBI in the Netherlands. Methods This study included data on all TBI patients who were treated at an Emergency Department (ED - National Injury Surveillance System), hospitalized (National Medical Registration), or died due to their injuries in the Netherlands between 2010–2012. Direct healthcare costs and indirect costs were determined using the incidence-based Dutch Burden of Injury Model. Disease burden was assessed by calculating years of life lost (YLL) owing to premature death, years lived with disability (YLD) and DALYs. Incidence, costs and disease burden were stratified by age and gender. Results TBI incidence was 213.6 per 100,000 person years. Total costs were €314.6 (USD $433.8) million per year and disease burden resulted in 171,200 DALYs (on average 7.1 DALYs per case). Men had highest mean costs per case (€19,540 versus €14,940), driven by indirect costs. 0–24-year-olds had high incidence and disease burden but low economic costs, whereas 25–64-year-olds had relatively low incidence but high economic costs. Patients aged 65+ had highest incidence, leading to considerable direct healthcare costs. 0–24-year-olds, men aged 25–64 years, traffic injury victims (especially bicyclists) and home and leisure injury victims (especially 0–5-year-old and elderly fallers) are identified as risk groups in TBI. Conclusions The economic and health consequences of TBI are substantial. The integrated approach of assessing incidence, costs and disease burden enables detection of important risk groups in TBI, development of prevention programs that

  8. High feeding costs limit dive time in the largest whales.

    PubMed

    Acevedo-Gutiérrez, A; Croll, D A; Tershy, B R

    2002-06-01

    Large body size usually extends dive duration in air-breathing vertebrates. However, the two largest predators on earth, the blue whale (Balaenoptera musculus) and the fin whale (B. physalus), perform short dives for their size. Here, we test the hypothesis that the foraging behavior of these two species (lunge-feeding) is energetically expensive and limits their dive duration. We estimated the cost of lunge-feeding in both species using an approach that combined attaching time/depth recorders to seven blue whales and eight fin whales and comparing the collected dive information with predictions made by optimality models of dive behavior. We show that the rate at which whales recovered from a foraging dive was twice that of a non-foraging dive and that the cost of foraging relative to the cost of travel to and from the prey patch was 3.15 in blue whales (95 % CI 2.58-3.72) and 3.60 in fin whales (95 % CI 2.35-4.85). Whales foraged in small areas (<1 km(2)) and foraging bouts lasted more than one dive, indicating that prey did not disperse and thus that prey dispersal could not account for the limited dive durations of the whales. Despite the enormous size of blue whales and fin whales, the high energetic costs of lunge-feeding confine them to short durations of submergence and to areas with dense prey aggregations. As a corollary, because of their limited foraging time under water, these whales may be particularly vulnerable to perturbations in prey abundance.

  9. 24 CFR 248.127 - Limitations on action pursuant to Federal cost limit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Federal cost limit. 248.127 Section 248.127 Housing and Urban Development Regulations Relating to Housing... HOUSING ACT AND OTHER AUTHORITIES PREPAYMENT OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of 1990 §...

  10. 24 CFR 248.127 - Limitations on action pursuant to Federal cost limit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Federal cost limit. 248.127 Section 248.127 Housing and Urban Development Regulations Relating to Housing... HOUSING ACT AND OTHER AUTHORITIES PREPAYMENT OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of 1990 §...

  11. Quality-adjusted cost of care: a meaningful way to measure growth in innovation cost versus the value of health gains.

    PubMed

    Lakdawalla, Darius; Shafrin, Jason; Lucarelli, Claudio; Nicholson, Sean; Khan, Zeba M; Philipson, Tomas J

    2015-04-01

    Technology drives both health care spending and health improvement. Yet policy makers rarely see measures of cost growth that account for both effects. To fill this gap, we present the quality-adjusted cost of care, which illustrates cost growth net of growth in the value of health improvements, measured as survival gains multiplied by the value of survival. We applied the quality-adjusted cost of care to two cases. For colorectal cancer, drug cost per patient increased by $34,493 between 1998 and 2005 as a result of new drug launches, but value from offsetting health improvements netted a modest $1,377 increase in quality-adjusted cost of care. For multiple myeloma, new therapies increased treatment cost by $72,937 between 2004 and 2009, but offsetting health benefits lowered overall quality-adjusted cost of care by $67,863. However, patients with multiple myeloma on established first-line therapies saw costs rise without corresponding benefits. All three examples document rapid cost growth, but they provide starkly different answers to the question of whether society got what it paid for.

  12. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  13. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  14. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  15. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  16. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  17. Empirical Assessment of Spatial Prediction Methods for Location Cost Adjustment Factors

    PubMed Central

    Migliaccio, Giovanni C.; Guindani, Michele; D'Incognito, Maria; Zhang, Linlin

    2014-01-01

    In the feasibility stage, the correct prediction of construction costs ensures that budget requirements are met from the start of a project's lifecycle. A very common approach for performing quick-order-of-magnitude estimates is based on using Location Cost Adjustment Factors (LCAFs) that compute historically based costs by project location. Nowadays, numerous LCAF datasets are commercially available in North America, but, obviously, they do not include all locations. Hence, LCAFs for un-sampled locations need to be inferred through spatial interpolation or prediction methods. Currently, practitioners tend to select the value for a location using only one variable, namely the nearest linear-distance between two sites. However, construction costs could be affected by socio-economic variables as suggested by macroeconomic theories. Using a commonly used set of LCAFs, the City Cost Indexes (CCI) by RSMeans, and the socio-economic variables included in the ESRI Community Sourcebook, this article provides several contributions to the body of knowledge. First, the accuracy of various spatial prediction methods in estimating LCAF values for un-sampled locations was evaluated and assessed in respect to spatial interpolation methods. Two Regression-based prediction models were selected, a Global Regression Analysis and a Geographically-weighted regression analysis (GWR). Once these models were compared against interpolation methods, the results showed that GWR is the most appropriate way to model CCI as a function of multiple covariates. The outcome of GWR, for each covariate, was studied for all the 48 states in the contiguous US. As a direct consequence of spatial non-stationarity, it was possible to discuss the influence of each single covariate differently from state to state. In addition, the article includes a first attempt to determine if the observed variability in cost index values could be, at least partially explained by independent socio-economic variables. PMID

  18. Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model

    SciTech Connect

    Andersen, M.E.; MacNaughton, M.G.; Clewell, H.J. III; Paustenbach, D.J.

    1987-04-01

    This paper advocates use of a physiologically-based pharmacokinetic (PB-PK) model for determining adjustment factors for unusual exposure schedules. The PB-PK model requires data on the blood:air and tissue:blood partition coefficients, the rate of metabolism of the chemical, organ volumes, organ blood flows and ventilation rates in humans. Laboratory data on two industrially important chemicals - styrene and methylene chloride - were used to illustrate the PB-PK approach. At inhaled concentrations near their respective 8-hr Threshold Limit Value - Time-weighted averages both of these chemicals are primarily eliminated from the body by metabolism. For these two chemicals, the appropriate risk indexing parameters are integrated tissue dose or total amount of parent chemical metabolized. These examples also illustrate how the model can be used to calculate risk based on various other measures of delivered dose. For the majority of volatile chemicals, the parameter most closely associated with risk is the integrated tissue dose. This analysis suggests that when pharmacokinetic data are not available, a simple inverse formula may be sufficient for adjustment in most instances and application of complex kinetic models unnecessary. At present, this PB-PK approach is recommended only for exposure periods of 4 to 16 hr/day, because the mechanisms of toxicity for some chemicals may vary for very short- or very long-term exposures. For these altered schedules, more biological information on recovery in rest periods and changing mechanisms of toxicity are necessary before any adjustment is attempted.

  19. Investigations of the use of bioavailability data to adjust occupational exposure limits for active pharmaceutical ingredients.

    PubMed

    Naumann, Bruce D; Weideman, Patricia A; Sarangapani, Ramesh; Hu, Shu-Cheih; Dixit, Rakesh; Sargent, Edward V

    2009-11-01

    Occupational exposure limits (OELs) for active pharmaceutical ingredients have traditionally been established using no-observed-adverse-effect levels derived from clinical studies employing po and iv routes of administration and by applying default uncertainty factors or chemical-specific adjustment factors. However, exposure by the inhalation or dermal route is more relevant in terms of occupational safety. In this investigation, to explore new methods for route-to-route extrapolation, the bioavailability of MK-0679, a leukotriene D(4) receptor antagonist, was compared following iv, po, intranasal (in), or intratracheal (it) administration. The relative bioavailability of MK-0679 was iv congruent with it > po congruent with in. Bioavailability correction factors (BCFs) of 2.0 and 0.6 were derived from these data to adjust a hypothetical OEL of 0.1 mg/m(3) for MK-0679 with particle sizes of 10 and 50 mum, respectively. These BCFs were used to adjust the OEL established using po clinical data, to reflect the differences in bioavailability following deposition in different regions of the respiratory tract. To further investigate how bioavailability data could be used in setting OELs, a preliminary pharmacokinetic (PK) model was developed to describe the time course of plasma concentrations using the data from the route comparison study. An inhalation study was then performed to test the validity of using either empirical data or modeling approaches to derive BCFs when setting OELs. These investigations demonstrated how the use of route-specific PK data could reduce some of the uncertainties associated with route-to-route extrapolation and allow for improved precision and quantitative adjustments when establishing OELs. Further investigations are needed to better understand the factors responsible for differences in systemic uptake following deposition in different regions of the respiratory tract and how these can be generalized across different classes of soluble

  20. Army ants dynamically adjust living bridges in response to a cost-benefit trade-off.

    PubMed

    Reid, Chris R; Lutz, Matthew J; Powell, Scott; Kao, Albert B; Couzin, Iain D; Garnier, Simon

    2015-12-01

    The ability of individual animals to create functional structures by joining together is rare and confined to the social insects. Army ants (Eciton) form collective assemblages out of their own bodies to perform a variety of functions that benefit the entire colony. Here we examine ‟bridges" of linked individuals that are constructed to span gaps in the colony's foraging trail. How these living structures adjust themselves to varied and changing conditions remains poorly understood. Our field experiments show that the ants continuously modify their bridges, such that these structures lengthen, widen, and change position in response to traffic levels and environmental geometry. Ants initiate bridges where their path deviates from their incoming direction and move the bridges over time to create shortcuts over large gaps. The final position of the structure depended on the intensity of the traffic and the extent of path deviation and was influenced by a cost-benefit trade-off at the colony level, where the benefit of increased foraging trail efficiency was balanced by the cost of removing workers from the foraging pool to form the structure. To examine this trade-off, we quantified the geometric relationship between costs and benefits revealed by our experiments. We then constructed a model to determine the bridge location that maximized foraging rate, which qualitatively matched the observed movement of bridges. Our results highlight how animal self-assemblages can be dynamically modified in response to a group-level cost-benefit trade-off, without any individual unit's having information on global benefits or costs.

  1. Army ants dynamically adjust living bridges in response to a cost-benefit trade-off.

    PubMed

    Reid, Chris R; Lutz, Matthew J; Powell, Scott; Kao, Albert B; Couzin, Iain D; Garnier, Simon

    2015-12-01

    The ability of individual animals to create functional structures by joining together is rare and confined to the social insects. Army ants (Eciton) form collective assemblages out of their own bodies to perform a variety of functions that benefit the entire colony. Here we examine ‟bridges" of linked individuals that are constructed to span gaps in the colony's foraging trail. How these living structures adjust themselves to varied and changing conditions remains poorly understood. Our field experiments show that the ants continuously modify their bridges, such that these structures lengthen, widen, and change position in response to traffic levels and environmental geometry. Ants initiate bridges where their path deviates from their incoming direction and move the bridges over time to create shortcuts over large gaps. The final position of the structure depended on the intensity of the traffic and the extent of path deviation and was influenced by a cost-benefit trade-off at the colony level, where the benefit of increased foraging trail efficiency was balanced by the cost of removing workers from the foraging pool to form the structure. To examine this trade-off, we quantified the geometric relationship between costs and benefits revealed by our experiments. We then constructed a model to determine the bridge location that maximized foraging rate, which qualitatively matched the observed movement of bridges. Our results highlight how animal self-assemblages can be dynamically modified in response to a group-level cost-benefit trade-off, without any individual unit's having information on global benefits or costs. PMID:26598673

  2. Traditional versus single-site placement of adjustable gastric banding: a comparative study and cost analysis.

    PubMed

    Ayloo, Subhashini M; Buchs, Nicolas C; Addeo, Pietro; Bianco, Francesco M; Giulianotti, Pier C

    2011-07-01

    In bariatric surgery, laparoscopic adjustable gastric banding (LAGB) has proven effective in reducing weight and improving obesity-associated comorbidities. Recently, however, laparoendoscopic single-site (LESS) surgery has been proposed to minimize the invasiveness of laparoscopic surgery. The aim of this study is to compare the operative cost and peri-operative outcomes of these two approaches. We undertook a retrospective review of a prospectively maintained database of patients undergoing either LAGB or LESS between March 2006 and October 2009. The outcomes and cost of 25 LESS gastric bandings were compared to 121 standard LAGB. Costs included operative time, consumables, and laparoscopic tower depreciation. Both groups had similar patient demographics, body mass index, and comorbidities; with the exception of age (37 year for single site vs. 44 years for standard; P=0.002). There were no statistical differences for operative time (78 vs. 76 min, P=0.69), blood loss (8.4 vs. 9 ml, P=0.76), pain score (0.81 vs. 0.84 at 1 week, P=0.95) or complication rates (12% vs. 14%, P=1). Length of stay was shorter for the LESS group (0.5 day vs. 1.5 days, P=0.02). The mean operative cost for the LESS banding was $20,502/case vs. $20,346/case for the standard LAGB, with no statistically significant difference between the approaches (P=0.73). Operative costs and peri-operative outcomes of LESS gastric banding are comparable with those of the standard LAGB procedure. As a result, single-site surgery can be proposed as a valid alternative to the standard procedure with cosmetic advantage and comparable complication rate. PMID:20809350

  3. Adjustment of costly extra-group paternity according to inbreeding risk in a cooperative mammal

    PubMed Central

    Cant, Michael A.; Sanderson, Jennifer L.

    2015-01-01

    Females of many animal species seek mating opportunities with multiple males, despite being able to obtain sufficient sperm to father their offspring from a single male. In animals that live in stable social groups, females often choose to mate outside their group resulting in extra-group paternity (EGP). One reason proposed to explain female choice for extra-group males is to obtain compatible genes, for example, in order to avoid inbreeding depression in offspring. The benefits of such extra-group paternities could be substantial if they result in fitter, outbred offspring. However, avoiding inbreeding in this way could be costly for females, for example, through retaliation by cuckolded males or through receiving aggression while prospecting for extra-group mating opportunities. We investigate the costs and benefits of EGP in the banded mongoose Mungos mungo, a cooperatively breeding mammal in which within-group mates are sometimes close relatives. We find that pups born to females that mate with extra-group males are more genetically heterozygous are heavier and are more likely to survive to independence than pups born to females that mate within their group. However, extra-group matings also involve substantial costs as they occur during violent encounters that sometimes result in injury and death. This appears to lead femalebanded mongooses to adaptively adjust EGP levels according to the current risk of inbreeding associated with mating within the group. For group-living animals, the costs of intergroup interactions may help to explain variation in both inbreeding rates and EGP within and between species. PMID:26609201

  4. 75 FR 49411 - Consumer Price Index Adjustments of Oil Pollution Act of 1990 Limits of Liability-Vessels and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... Index Adjustments of Oil Pollution Act of 1990 Limits of Liability--Vessels and Deepwater Ports'' (74 FR... Number 1625-0046 entitled ``Financial Responsibility for Water Pollution (Vessels).'' The approval for... SECURITY Coast Guard 33 CFR Part 138 RIN 1625-AB25 Consumer Price Index Adjustments of Oil Pollution Act...

  5. Costing the Morbidity and Mortality Consequences of Zoonoses Using Health-Adjusted Life Years.

    PubMed

    Jordan, H; Dunt, D; Hollingsworth, B; Firestone, S M; Burgman, M

    2016-10-01

    Governments are routinely involved in the biosecurity of agricultural and food imports and exports. This involves controlling the complex ongoing threat of the broad range of zoonoses: endemic, exotic and newly emerging. Policy-related decision-making in these areas requires accurate information and predictions concerning the effects and potential impacts of zoonotic diseases. The aim of this article was to provide information concerning the development and use of utility-based tools, specifically disability-adjusted life years (DALYs), for measuring the burden on human disease (morbidity and mortality) as a consequence of zoonotic infections. Issues and challenges to their use are also considered. Non-monetary utility approaches that are reviewed in this paper form one of a number of tools that can be used to estimate the monetary and non-monetary 'cost' of morbidity- and mortality-related consequences. Other tools derive from cost-of-illness, willingness-to-pay and multicriteria approaches. Utility-based approaches are specifically designed to capture the pain, suffering and loss of functioning associated with diseases, zoonotic and otherwise. These effects are typically complicated to define, measure and subsequently 'cost'. Utility-based measures will not be able to capture all of the effects, especially those that extend beyond the health sector. These will more normally be captured in financial terms. Along with other uncommon diseases, the quality of the relevant epidemiological data may not be adequate to support the estimation of losses in utility as a result of zoonoses. Other issues in their use have been identified. New empirical studies have shown some success in addressing these issues. Other issues await further study. It is concluded that, bearing in mind all caveats, utility-based methods are important tools in assessing the magnitude of the impacts of zoonoses in human disease. They make an important contribution to decision-making and priority

  6. Applying risk adjusted cost-effectiveness (RAC-E) analysis to hospitals: estimating the costs and consequences of variation in clinical practice.

    PubMed

    Karnon, Jonathan; Caffrey, Orla; Pham, Clarabelle; Grieve, Richard; Ben-Tovim, David; Hakendorf, Paul; Crotty, Maria

    2013-06-01

    Cost-effectiveness analysis is well established for pharmaceuticals and medical technologies but not for evaluating variations in clinical practice. This paper describes a novel methodology--risk adjusted cost-effectiveness (RAC-E)--that facilitates the comparative evaluation of applied clinical practice processes. In this application, risk adjustment is undertaken with a multivariate matching algorithm that balances the baseline characteristics of patients attending different settings (e.g., hospitals). Linked, routinely collected data are used to analyse patient-level costs and outcomes over a 2-year period, as well as to extrapolate costs and survival over patient lifetimes. The study reports the relative cost-effectiveness of alternative forms of clinical practice, including a full representation of the statistical uncertainty around the mean estimates. The methodology is illustrated by a case study that evaluates the relative cost-effectiveness of services for patients presenting with acute chest pain across the four main public hospitals in South Australia. The evaluation finds that services provided at two hospitals were dominated, and of the remaining services, the more effective hospital gained life years at a low mean additional cost and had an 80% probability of being the most cost-effective hospital at realistic cost-effectiveness thresholds. Potential determinants of the estimated variation in costs and effects were identified, although more detailed analyses to identify specific areas of variation in clinical practice are required to inform improvements at the less cost-effective institutions.

  7. [Ecodialysis: first strategies to limit damages and reduce costs].

    PubMed

    Ferraresi, Martina; Nazha, Marta; Vigotti, Federica Neve; Pereno, Amina; Di Giorgio, Gerardo; Gatti, Rachele; Luisa, Bevilacqua Maria; Miriam, Cagnazzo; Barbara, Cassetta; Giovanna, Denti; Gaetana, Grimaldi; Monterossi, Marianna; Barbero, Silvia; Piccoli, Giorgina Barbara

    2014-01-01

    In the medical field, the attention to the environmental impact of industrial processes and products is still limited. In recent years there has been an increased sensitivity towards the environment; meanwhile, the economic burden of hazardous waste disposal is becoming evident. Dialysis is a "big producer" of waste and it has been estimated that disposal costs can be up to 10-40% of the cost of disposables. So there are several reasons of interest on "ecodialysis": the high amount of waste defined as "potentially hazardous", which requires a very expensive management and the recyclability potential of the non-contaminated waste, that has not yet been fully explored in dialysis. This primary study has been performed in collaboration with the Politecnico di Torino. Its aim has been to define a schedule of activities by a few brainstorming sessions. This schedule is to be readily performed or it should be developed in detail to optimize, by reducing and recycling, the waste production during the dialysis session. The discussion identified seven basic points for the eco-sustainability of haemodialysis to: [1] reduce packaging; [2] facilitate separation of materials, and [3] their discharge; [4] differentiate materials; [5] clearly highlight the potentially hazardous materials; [6] improve the recyclability of plastic products; [7] propose a path of recovery and reuse. Although a full optimization requires a close cooperation with the manufacturers and is achievable only in the long term, the reduction of one pound of potentially contaminated materials could presently lead, on a national scale, to a saving of several million euros, which can be better employed in investments to improve our treatments. PMID:25315732

  8. 45 CFR 63.18 - Limitations on costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... costs. The amount of the award shall be set forth in the grant award document. The total cost to the Government will not exceed the amount set forth in the grant award document or any modification thereof.... The Government shall not be obligated to reimburse the grantee for costs incurred in excess of...

  9. 77 FR 8724 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits... (OEP) computes and publishes the project cost and annual limits for natural gas pipelines blanket... establishes cost limits applicable from January 1, 2012 through December 31, 2012. FOR FURTHER...

  10. 76 FR 8293 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits...) computes and publishes the project cost and annual limits for natural gas pipelines blanket construction.... Applicability date: This final rule establishes cost limits applicable from January 1, 2011 through December...

  11. Costing the Morbidity and Mortality Consequences of Zoonoses Using Health-Adjusted Life Years.

    PubMed

    Jordan, H; Dunt, D; Hollingsworth, B; Firestone, S M; Burgman, M

    2016-10-01

    Governments are routinely involved in the biosecurity of agricultural and food imports and exports. This involves controlling the complex ongoing threat of the broad range of zoonoses: endemic, exotic and newly emerging. Policy-related decision-making in these areas requires accurate information and predictions concerning the effects and potential impacts of zoonotic diseases. The aim of this article was to provide information concerning the development and use of utility-based tools, specifically disability-adjusted life years (DALYs), for measuring the burden on human disease (morbidity and mortality) as a consequence of zoonotic infections. Issues and challenges to their use are also considered. Non-monetary utility approaches that are reviewed in this paper form one of a number of tools that can be used to estimate the monetary and non-monetary 'cost' of morbidity- and mortality-related consequences. Other tools derive from cost-of-illness, willingness-to-pay and multicriteria approaches. Utility-based approaches are specifically designed to capture the pain, suffering and loss of functioning associated with diseases, zoonotic and otherwise. These effects are typically complicated to define, measure and subsequently 'cost'. Utility-based measures will not be able to capture all of the effects, especially those that extend beyond the health sector. These will more normally be captured in financial terms. Along with other uncommon diseases, the quality of the relevant epidemiological data may not be adequate to support the estimation of losses in utility as a result of zoonoses. Other issues in their use have been identified. New empirical studies have shown some success in addressing these issues. Other issues await further study. It is concluded that, bearing in mind all caveats, utility-based methods are important tools in assessing the magnitude of the impacts of zoonoses in human disease. They make an important contribution to decision-making and priority

  12. 24 CFR 891.140 - Development cost limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... add energy efficiency features. (b) The Replacement Reserve Account established under paragraph (a) of... Notice in the Federal Register and adjusted by locality, to calculate the fund reservation amount of the... are less than the amount of the initial fund reservation shall be entitled to retain 50 percent of...

  13. Reverse-total shoulder arthroplasty cost-effectiveness: A quality-adjusted life years comparison with total hip arthroplasty

    PubMed Central

    Bachman, Daniel; Nyland, John; Krupp, Ryan

    2016-01-01

    AIM: To compare reverse-total shoulder arthroplasty (RSA) cost-effectiveness with total hip arthroplasty cost-effectiveness. METHODS: This study used a stochastic model and decision-making algorithm to compare the cost-effectiveness of RSA and total hip arthroplasty. Fifteen patients underwent pre-operative, and 3, 6, and 12 mo post-operative clinical examinations and Short Form-36 Health Survey completion. Short form-36 Health Survey subscale scores were converted to EuroQual Group Five Dimension Health Outcome scores and compared with historical data from age-matched patients who had undergone total hip arthroplasty. Quality-adjusted life year (QALY) improvements based on life expectancies were calculated. RESULTS: The cost/QALY was $3900 for total hip arthroplasty and $11100 for RSA. After adjusting the model to only include shoulder-specific physical function subscale items, the RSA QALY improved to 2.8 years, and its cost/QALY decreased to $8100. CONCLUSION: Based on industry accepted standards, cost/QALY estimates supported both RSA and total hip arthroplasty cost-effectiveness. Although total hip arthroplasty remains the quality of life improvement “gold standard” among arthroplasty procedures, cost/QALY estimates identified in this study support the growing use of RSA to improve patient quality of life. PMID:26925384

  14. A Cost-Effective Fluorescence Mini-Microscope with Adjustable Magnifications for Biomedical Applications

    PubMed Central

    Zhang, Yu Shrike; Ribas, João; Nadhman, Akhtar; Aleman, Julio; Selimović, Šeila; Lesher-Perez, Sasha Cai; Wang, Ting; Manoharan, Vijayan; Shin, Su-Ryon; Damilano, Alessia; Annabi, Nasim; Dokmeci, Mehmet Remzi; Takayama, Shuichi; Khademhosseini, Ali

    2015-01-01

    We have designed and fabricated a miniature microscope from off-the-shelf components and webcam, with built-in fluorescence capability for biomedical applications. The mini-microscope was able to detect both biochemical parameters such as cell/tissue viability (e.g. Live/Dead assay), and biophysical properties of the microenvironment such as oxygen levels in microfabricated tissues based on an oxygen-sensitive fluorescent dye. This mini-microscope has adjustable magnifications from 8-60X, achieves a resolution as high as <2 μm, and possesses a long working distance of 4.5 mm (at a magnification of 8X). The mini-microscope was able to chronologically monitor cell migration and analyze beating of microfluidic liver and cardiac bioreactors in real time, respectively. The mini-microscope system is cheap, and its modularity allows convenient integration with a wide variety of pre-existing platforms including but not limited to, cell culture plates, microfluidic devices, and organs-on-a-chip systems. Therefore, we envision its widespread applications in cell biology, tissue engineering, biosensing, microfluidics, and organs-on-chips, which can potentially replace conventional bench-top microscopy where long-term in situ and large-scale imaging/analysis is required. PMID:26282117

  15. Risk-Adjusted Impact of Administrative Costs on the Distribution of Terminal Wealth for Long-Term Investment

    PubMed Central

    Guillén, Montserrat; Jarner, Søren Fiig; Pérez-Marín, Ana M.

    2014-01-01

    The impact of administrative costs on the distribution of terminal wealth is approximated using a simple formula applicable to many investment situations. We show that the reduction in median returns attributable to administrative fees is usually at least twice the amount of the administrative costs charged for most investment funds, when considering a risk-adjustment correction over a reasonably long-term time horizon. The example we present covers a number of standard cases and can be applied to passive investments, mutual funds, and hedge funds. Our results show investors the potential losses they face in performance due to administrative costs. PMID:25180200

  16. Risk-adjusted impact of administrative costs on the distribution of terminal wealth for long-term investment.

    PubMed

    Guillén, Montserrat; Jarner, Søren Fiig; Nielsen, Jens Perch; Pérez-Marín, Ana M

    2014-01-01

    The impact of administrative costs on the distribution of terminal wealth is approximated using a simple formula applicable to many investment situations. We show that the reduction in median returns attributable to administrative fees is usually at least twice the amount of the administrative costs charged for most investment funds, when considering a risk-adjustment correction over a reasonably long-term time horizon. The example we present covers a number of standard cases and can be applied to passive investments, mutual funds, and hedge funds. Our results show investors the potential losses they face in performance due to administrative costs.

  17. Risk-adjusted impact of administrative costs on the distribution of terminal wealth for long-term investment.

    PubMed

    Guillén, Montserrat; Jarner, Søren Fiig; Nielsen, Jens Perch; Pérez-Marín, Ana M

    2014-01-01

    The impact of administrative costs on the distribution of terminal wealth is approximated using a simple formula applicable to many investment situations. We show that the reduction in median returns attributable to administrative fees is usually at least twice the amount of the administrative costs charged for most investment funds, when considering a risk-adjustment correction over a reasonably long-term time horizon. The example we present covers a number of standard cases and can be applied to passive investments, mutual funds, and hedge funds. Our results show investors the potential losses they face in performance due to administrative costs. PMID:25180200

  18. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Cost limitations on... Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of self-employment plans. A self-employment plan with an estimated or actual cost of less than $25,000 may...

  19. 34 CFR 75.531 - Limit on total cost of a project.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Limit on total cost of a project. 75.531 Section 75.531 Education Office of the Secretary, Department of Education DIRECT GRANT PROGRAMS What Conditions Must Be Met by a Grantee? Allowable Costs § 75.531 Limit on total cost of a project. A grantee shall insure...

  20. Alpine scree plants benefit from cryptic coloration with limited cost.

    PubMed

    Niu, Yang; Sun, Hang

    2014-01-01

    Like animals, plants are attacked by enemies (herbivores) that forage using visual cues; however, the defensive coloration type known as cryptic coloration was rarely reported in plants. For most autotrophic plants, because photosynthesis relies on the presence of chlorophyll, a green leaf appearance is standard. However, if having leaves that are not green is more beneficial than costly, such coloration may evolve under certain conditions. Taking advantage of the leaf color dimorphism of Corydalis benecincta, we showed that the cryptically colored leaves confer a clear benefit without obvious cost in natural populations. Based on this study, we try to provide a framework on which to base a cost-benefit analysis to investigate the evolution of cryptic leaf coloration in plants.

  1. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR... a second preceding cost period and is a new provider as defined in § 413.30(e), the...

  2. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR... a second preceding cost period and is a new provider as defined in § 413.30(e), the...

  3. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR... a second preceding cost period and is a new provider as defined in § 413.30(e), the...

  4. 32 CFR 3.6 - Limitations on cost-sharing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... counted as provided, or to be provided, by the business units of an awardee or subawardee participating in... the OT agreement becomes effective. Costs that were incurred for a prototype project by the business... before the OT agreement became effective in order to ensure the successful implementation of the...

  5. 5 CFR 838.622 - Cost-of-living and salary adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the former spouse's share effective at the time of divorce or separation entitles the former spouse to... employee. (ii) To prevent the application of salary adjustments after the date of the divorce or...

  6. Efficient and Cost-Effective Use of Adjustable Canopy Hoods in a Chemistry Laboratory.

    ERIC Educational Resources Information Center

    Rothchild, Robert

    1988-01-01

    Suggests the use of small canopy hoods that provide flexibility of vertical and horizontal adjustment over the lab bench as a replacement for permanent hoods. Includes many safety related instances where canopy hoods should be used. (MVL)

  7. 38 CFR 3.28 - Automatic adjustment of section 306 and old-law pension income limitations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Automatic adjustment of section 306 and old-law pension income limitations. 3.28 Section 3.28 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and...

  8. 39 CFR 3010.22 - Calculation of annual limitation when notices of rate adjustment are less than 12 months apart.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... dividing the sum by 12 (Recent Average). The partial year limitation is then calculated by dividing the Recent Average by the Recent Average from the most recent previous notice of rate adjustment (Previous Recent Average) applicable to each affected class of mail and subtracting 1 from the quotient. The...

  9. 38 CFR 3.28 - Automatic adjustment of section 306 and old-law pension income limitations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Automatic adjustment of section 306 and old-law pension income limitations. 3.28 Section 3.28 Pensions, Bonuses, and Veterans.... Whenever the maximum annual rates of improved pension are increased by reason of the provisions of 38...

  10. The Cost-Effectiveness of Laparoscopic Adjustable Gastric Banding in the Morbidly Obese Adult Population of Australia

    PubMed Central

    Lee, Yong Yi; Veerman, J. Lennert; Barendregt, Jan J.

    2013-01-01

    Background To examine the cost-effectiveness of providing laparoscopic adjustable gastric banding (LAGB) surgery to all morbidly obese adults in the 2003 Australian population. Methods and Findings Analyzed costs and benefits associated with two intervention scenarios, one providing LAGB surgery to individuals with BMI >40 and another to individuals with BMI >35, with each compared relative to a ‘do nothing’ scenario. A multi-state, multiple cohort Markov model was used to determine the cost-effectiveness of LAGB surgery over the lifetime of each cohort. All costs and health outcomes were assessed from an Australian health sector perspective and were discounted using a 3% annual rate. Uncertainty and sensitivity analyzes were conducted to test the robustness of model outcomes. Incremental cost-effectiveness ratios (ICERs) were measured in 2003 Australian dollars per disability adjusted life year (DALY) averted. The ICER for the scenario providing LAGB surgery to all individuals with a BMI >40 was dominant [95% CI: dominant - $588] meaning that the intervention led to both improved health and cost savings. The ICER when providing surgery to those with a BMI >35 was $2 154/DALY averted [95% CI: dominant - $6 033]. Results were highly sensitive to changes in the likelihood of long-term complications. Conclusion LAGB surgery is highly cost-effective when compared to the $50 000/DALY threshold for cost-effectiveness used in Australia. LAGB surgery also ranks highly in terms of cost-effectiveness when compared to other population-level interventions for weight loss in Australia. The results of this study are in line with other economic evaluations on LAGB surgery. This study recommends that the Australian federal government provide a full subsidy for LAGB surgery to morbidly obese Australians with a BMI >40. PMID:23717680

  11. A Primer for Making Cost Adjustments in Education. Research and Development Report.

    ERIC Educational Resources Information Center

    Fowler, William J., Jr.; Monk, David H.

    Efforts to compare the costs of exactly the same things in different geographic regions involve comparisons of the same "market basket" of goods in two geographic areas. Measuring cost differences in education, however, is difficult, since most of the costs are in personnel, rather than in supplies. This publication explains the differences…

  12. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true What types of costs are subject to the administrative cost limit on Tribal Family Assistance Grant funds? 286.55 Section 286.55 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH...

  13. 34 CFR 609.41 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are allowable costs and what are the limitations on allowable costs? 609.41 Section 609.41 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STRENGTHENING HISTORICALLY BLACK GRADUATE INSTITUTIONS PROGRAM...

  14. 34 CFR 607.30 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are allowable costs and what are the limitations on allowable costs? 607.30 Section 607.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STRENGTHENING INSTITUTIONS PROGRAM What Conditions Must a Grantee...

  15. 34 CFR 606.30 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What are allowable costs and what are the limitations on allowable costs? 606.30 Section 606.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING...

  16. 34 CFR 606.30 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What are allowable costs and what are the limitations on allowable costs? 606.30 Section 606.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING...

  17. 34 CFR 606.30 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What are allowable costs and what are the limitations on allowable costs? 606.30 Section 606.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING...

  18. 34 CFR 606.30 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What are allowable costs and what are the limitations on allowable costs? 606.30 Section 606.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING...

  19. 34 CFR 606.30 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are allowable costs and what are the limitations on allowable costs? 606.30 Section 606.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION DEVELOPING...

  20. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... safe harbor methodology of this paragraph (a)(6) if— (A) The employee has received one or more... otherwise satisfied the safe harbor methodology described in paragraph (a)(5) of this section. For purposes... adjustments. Pursuant to section 415(d)(4)(A), the $5,000 rounding methodology of paragraph (a)(1)(iii)...

  1. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... safe harbor methodology of this paragraph (a)(6) if— (A) The employee has received one or more... otherwise satisfied the safe harbor methodology described in paragraph (a)(5) of this section. For purposes... adjustments. Pursuant to section 415(d)(4)(A), the $5,000 rounding methodology of paragraph (a)(1)(iii)...

  2. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... safe harbor methodology of this paragraph (a)(6) if— (A) The employee has received one or more... otherwise satisfied the safe harbor methodology described in paragraph (a)(5) of this section. For purposes... adjustments. Pursuant to section 415(d)(4)(A), the $5,000 rounding methodology of paragraph (a)(1)(iii)...

  3. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the Commission's Uniform System of Accounts 18 CFR part 101, Definitions 5B. (8) All rate filings... Energy Organization Act, 42 U.S.C. 7171, 7172 and 7173(c) (Supp. IV 1980); E.O. 12009, 3 CFR part 142... and in the current period: Adjustment Factor =Fm/Sm-Fb/Sb Where: F is the expense of fossil...

  4. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the Commission's Uniform System of Accounts 18 CFR part 101, Definitions 5B. (8) All rate filings... Energy Organization Act, 42 U.S.C. 7171, 7172 and 7173(c) (Supp. IV 1980); E.O. 12009, 3 CFR part 142... and in the current period: Adjustment Factor =Fm/Sm-Fb/Sb Where: F is the expense of fossil...

  5. 76 FR 40817 - Cost Accounting Standards: Change to the CAS Applicability Threshold for the Inflation Adjustment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... to the CAS Applicability Threshold for the Inflation Adjustment to the Truth in Negotiations Act... revising the threshold for the application of CAS from ``$650,000'' to ``the Truth in Negotiations Act... are open for comment. Simply type ``CAS-TINA Threshold'' (without quotation marks) in the Comment...

  6. 32 CFR 269.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... adjustment” means the percentage (if any) for each civil monetary penalty by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment, exceeds the Consumer Price Index... Subsequent Offense 20,000 22,000 31 U.S.C. 1352 Use of Appropriated Funds to Influence Contract: Minimum...

  7. A Comparable Wage Approach to Geographic Cost Adjustment. Research and Development Report. NCES-2006-321

    ERIC Educational Resources Information Center

    Taylor, Lori L.; Fowler, William J. Jr.

    2006-01-01

    Geographic cost differences present many complications when researchers attempt to make systematic comparisons of educational resources, and failure to address such differences can undermine the equity and adequacy goals of school finance formulas. Therefore, there is considerable interest in developing measures of the cost of education that can…

  8. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... defined in paragraph (a)(11) of this section, if the reserve capacity of the buyer is adequate independent... buyer's total avoided variable cost; (v) And less the cost of fossil and nuclear fuel recovered through... the Commission's Uniform System of Accounts 18 CFR part 101, Definitions 5B. (8) All rate...

  9. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... defined in paragraph (a)(11) of this section, if the reserve capacity of the buyer is adequate independent... buyer's total avoided variable cost; (v) And less the cost of fossil and nuclear fuel recovered through... the Commission's Uniform System of Accounts 18 CFR part 101, Definitions 5B. (8) All rate...

  10. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... defined in paragraph (a)(11) of this section, if the reserve capacity of the buyer is adequate independent... buyer's total avoided variable cost; (v) And less the cost of fossil and nuclear fuel recovered through... the Commission's Uniform System of Accounts 18 CFR part 101, Definitions 5B. (8) All rate...

  11. Phenology, growth and physiological adjustments of oil palm (Elaeis guineensis) to sink limitation induced by fruit pruning

    PubMed Central

    Legros, S.; Mialet-Serra, I.; Caliman, J.-P.; Siregar, F. A.; Clement-Vidal, A.; Fabre, D.; Dingkuhn, M.

    2009-01-01

    Background and Aims Despite its simple architecture and small phenotypic plasticity, oil palm has complex phenology and source–sink interactions. Phytomers appear in regular succession but their development takes years, involving long lag periods between environmental influences and their effects on sinks. Plant adjustments to resulting source–sink imbalances are poorly understood. This study investigated oil palm adjustments to imbalances caused by severe fruit pruning. Methods An experiment with two treatments (control and complete fruit pruning) during 22 months in 2006–2008) and six replications per treatment was conducted in Indonesia. Phenology, growth of above-ground vegetative and reproductive organs, leaf morphology, inflorescence sex differentiation, dynamics of non-structural carbohydrate reserves and light-saturated net photosynthesis (Amax) were monitored. Key Results Artificial sink limitation by complete fruit pruning accelerated development rate, resulting in higher phytomer, leaf and inflorescence numbers. Leaf size and morphology remained unchanged. Complete fruit pruning also suppressed the abortion of male inflorescences, estimated to be triggered at about 16 months before bunch maturity. The number of female inflorescences increased after an estimated lag of 24–26 months, corresponding to time from sex differentiation to bunch maturity. The most important adjustment process was increased assimilate storage in the stem, attaining nearly 50 % of dry weight in the stem top, mainly as starch, whereas glucose, which in controls was the most abundant non-structural carbohydrate stored in oil palm, decreased. Conclusions The development rate of oil palm is in part controlled by source–sink relationships. Although increased rate of development and proportion of female inflorescences constituted observed adjustments to sink limitation, the low plasticity of plant architecture (constant leaf size, absence of branching) limited compensatory

  12. What are the costs of limiting CO2 concentrations?

    SciTech Connect

    Edmonds, James A.; Sands, Ronald D.

    2003-01-01

    The problem of stabilizing the concentration of CO2 is fundamentally different than the problem of stabilizing the concentration of a conventional pollutant or even other non-CO2 greenhouse gases. A fraction of any net anthropogenic emission is permanently committed to the atmosphere and in the very long term net anthropogenic emissions must cease if atmospheric CO2 concentrations are to be stabilized. Many of the technologies that could play a large future role in limiting cumulative carbon emissions are minor elements in the present energy system. A portfolio of technologies will be needed to address the variety of technology needs across the world's regions and over time.

  13. 75 FR 8245 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits...) computes and publishes the project cost and annual limits for natural gas pipelines blanket construction certificates for each calendar year. DATES: This final rule is effective February 24, 2010 and establishes...

  14. 78 FR 8389 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits AGENCY... publishes the project cost and annual limits for natural gas pipelines blanket construction certificates for... CFR Part 157 Administrative practice and procedure, Natural Gas, Reporting and...

  15. 78 FR 56911 - Notice of Certain Operating Cost Adjustment Factors for 2014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... Bureau of Labor Statistics (BLS) Consumer Price Index, All Items Less Food, Energy and Shelter (Series ID... . Natural Gas: Energy Information Agency, Natural Gas, Residential Energy Price, 2011-2012 annual prices in... (77 FR 63324). Specifically, OCAFs are calculated as the sum of weighted average cost changes...

  16. 77 FR 63324 - Notice of Certain Operating Cost Adjustment Factors for 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... CUUR0000SEHD) at the national level. Fuel Oil: The Energy Information Agency Retail Price of No. 2 Fuel Oil to..., Natural Gas, Residential Energy Price, 2010-2011 annual prices in dollars per 1,000 cubic feet at the... (76 FR 66319). Specifically, OCAFs are calculated as the sum of weighted average cost changes...

  17. 78 FR 40665 - Cost Accounting Standards: CAS 413 Pension Adjustments for Extraordinary Events

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... Cost Credits, 413-50(c)(3) Pension Plan Merger or Spin-Off, 413-50(c)(5) Initial Allocation of Plan... prior mergers, spin-offs or other reorganizations? (e) If liabilities were accumulated across many years... period of time during the life of the segment? (b) What if there have been prior mergers, spin-offs...

  18. 76 FR 79545 - Cost Accounting Standards: Change to the CAS Applicability Threshold for the Inflation Adjustment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... request for comment (76 FR 40817) for the purpose of revising the Cost Accounting Standards (CAS... Acquisition Regulations Council on August 30, 2010 (at 75 FR 53129). By revising the CAS applicability... Council (Councils) published a final rule in the Federal Register on August 30, 2010 (75 FR...

  19. Adjusting for Differences Among School Districts in the Costs of Educational Inputs. A Feasibility Report.

    ERIC Educational Resources Information Center

    Brazer, Harvey E.; Anderson, Ann P.

    To the extent that costs do vary among school districts, neither an equal dollar distribution of funds nor an equal-yield per unit of tax effort can achieve equality of educational inputs or the capacity to acquire them. This document addresses problems relating to the development of guidelines to achieve equality in educational inputs, or…

  20. Comparing Medical Costs and Use After Laparoscopic Adjustable Gastric Banding and Roux-en-Y Gastric Bypass

    PubMed Central

    Lewis, Kristina H.; Zhang, Fang; Arterburn, David E.; Ross-Degnan, Dennis; Gillman, Matthew W.; Wharam, J. Frank

    2015-01-01

    IMPORTANCE There is conflicting evidence about how different bariatric procedures impact health care use. OBJECTIVE To compare the impact of laparoscopic adjustable gastric banding (AGB) and laparoscopic Roux-en-Y gastric bypass (RYGB) on health care use and costs. DESIGN, SETTING, AND PARTICIPANTS Retrospective interrupted time series with comparison series study using a national claims data set. The data analysis was initiated in September 2011 and completed in January 2015. We identified bariatric surgery patients aged 18 to 64 years who underwent a first AGB or RYGB between 2005 and 2011. We propensity score matched 4935 AGB to 4935 RYGB patients according to baseline age group, sex, race/ethnicity, socioeconomic variables, comorbidities, year of procedure and baseline costs, emergency department (ED) visits, and hospital days. Median postoperative follow-up time was 2.5 years. MAIN OUTCOMES AND MEASURES Quarterly and yearly total health care costs, ED visits, hospital days, and prescription drug costs. We used segmented regression to compare pre-to-post changes in level and trend of these measures in the AGB vs the RYGB groups and difference-in-differences analysis to estimate the magnitude of difference by year. RESULTS Both AGB and RYGB were associated with downward trends in costs; however, by year 3, AGB patients had total annual costs that were 16% higher than RYGB patients (P < .001; absolute change: $818; 95% CI, $278 to $1357). In postoperative years 1 and 2, AGB was associated with 27% to 29% fewer ED visits than RYGB (P < .001; absolute changes: −0.6; 95% CI, −0.9 to −0.4 and −0.4; 95% CI, −0.6 to −0.1 visits/person, respectively); however, by year 3, there were no detectable differences. Postoperative annual hospital days were not significantly different between the groups. Although both procedures lowered prescription costs, annual postoperative prescription costs were 17% to 32% higher for AGB patients than RYGB patients (P < .001

  1. 77 FR 46633 - Parts and Accessories Necessary for Safe Operation: Brakes; Adjustment Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    .... Background Appendix G, Minimum Periodic Inspection Standards, was added to the FMCSRs in 1988 (53 FR 49411... Operation; General Amendments'' (62 FR 18169, Apr. 14, 1997). The NPRM proposed various amendments to 49 CFR...-limits tables. FMCSA published the final rule on August 15, 2005 (70 FR 48007). The Agency revised...

  2. 20 CFR 672.510 - What cost limits apply to the use of YouthBuild program funds?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... definition of administrative costs can be found in 20 CFR 667.220. (b) The cost of supervision and training... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false What cost limits apply to the use of Youth... Limitations § 672.510 What cost limits apply to the use of YouthBuild program funds? (a) Administrative...

  3. 20 CFR 672.510 - What cost limits apply to the use of YouthBuild program funds?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... definition of administrative costs can be found in 20 CFR 667.220. (b) The cost of supervision and training... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What cost limits apply to the use of Youth... Limitations § 672.510 What cost limits apply to the use of YouthBuild program funds? (a) Administrative...

  4. 20 CFR 672.510 - What cost limits apply to the use of YouthBuild program funds?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... definition of administrative costs can be found in 20 CFR 667.220. (b) The cost of supervision and training... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false What cost limits apply to the use of Youth... Limitations § 672.510 What cost limits apply to the use of YouthBuild program funds? (a) Administrative...

  5. Constraints on the evolution of phenotypic plasticity: limits and costs of phenotype and plasticity

    PubMed Central

    Murren, C J; Auld, J R; Callahan, H; Ghalambor, C K; Handelsman, C A; Heskel, M A; Kingsolver, J G; Maclean, H J; Masel, J; Maughan, H; Pfennig, D W; Relyea, R A; Seiter, S; Snell-Rood, E; Steiner, U K; Schlichting, C D

    2015-01-01

    Phenotypic plasticity is ubiquitous and generally regarded as a key mechanism for enabling organisms to survive in the face of environmental change. Because no organism is infinitely or ideally plastic, theory suggests that there must be limits (for example, the lack of ability to produce an optimal trait) to the evolution of phenotypic plasticity, or that plasticity may have inherent significant costs. Yet numerous experimental studies have not detected widespread costs. Explicitly differentiating plasticity costs from phenotype costs, we re-evaluate fundamental questions of the limits to the evolution of plasticity and of generalists vs specialists. We advocate for the view that relaxed selection and variable selection intensities are likely more important constraints to the evolution of plasticity than the costs of plasticity. Some forms of plasticity, such as learning, may be inherently costly. In addition, we examine opportunities to offset costs of phenotypes through ontogeny, amelioration of phenotypic costs across environments, and the condition-dependent hypothesis. We propose avenues of further inquiry in the limits of plasticity using new and classic methods of ecological parameterization, phylogenetics and omics in the context of answering questions on the constraints of plasticity. Given plasticity's key role in coping with environmental change, approaches spanning the spectrum from applied to basic will greatly enrich our understanding of the evolution of plasticity and resolve our understanding of limits. PMID:25690179

  6. Constraints on the evolution of phenotypic plasticity: limits and costs of phenotype and plasticity.

    PubMed

    Murren, C J; Auld, J R; Callahan, H; Ghalambor, C K; Handelsman, C A; Heskel, M A; Kingsolver, J G; Maclean, H J; Masel, J; Maughan, H; Pfennig, D W; Relyea, R A; Seiter, S; Snell-Rood, E; Steiner, U K; Schlichting, C D

    2015-10-01

    Phenotypic plasticity is ubiquitous and generally regarded as a key mechanism for enabling organisms to survive in the face of environmental change. Because no organism is infinitely or ideally plastic, theory suggests that there must be limits (for example, the lack of ability to produce an optimal trait) to the evolution of phenotypic plasticity, or that plasticity may have inherent significant costs. Yet numerous experimental studies have not detected widespread costs. Explicitly differentiating plasticity costs from phenotype costs, we re-evaluate fundamental questions of the limits to the evolution of plasticity and of generalists vs specialists. We advocate for the view that relaxed selection and variable selection intensities are likely more important constraints to the evolution of plasticity than the costs of plasticity. Some forms of plasticity, such as learning, may be inherently costly. In addition, we examine opportunities to offset costs of phenotypes through ontogeny, amelioration of phenotypic costs across environments, and the condition-dependent hypothesis. We propose avenues of further inquiry in the limits of plasticity using new and classic methods of ecological parameterization, phylogenetics and omics in the context of answering questions on the constraints of plasticity. Given plasticity's key role in coping with environmental change, approaches spanning the spectrum from applied to basic will greatly enrich our understanding of the evolution of plasticity and resolve our understanding of limits.

  7. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... approved by the VR&E Officer with jurisdiction. Any self-employment plan with an estimated or actual cost of $25,000 or more must be approved by the Director, VR&E Service. (Authority: 38 U.S.C. 3104... Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of...

  8. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... approved by the VR&E Officer with jurisdiction. Any self-employment plan with an estimated or actual cost of $25,000 or more must be approved by the Director, VR&E Service. (Authority: 38 U.S.C. 3104... Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of...

  9. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... approved by the VR&E Officer with jurisdiction. Any self-employment plan with an estimated or actual cost of $25,000 or more must be approved by the Director, VR&E Service. (Authority: 38 U.S.C. 3104... Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of...

  10. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... approved by the VR&E Officer with jurisdiction. Any self-employment plan with an estimated or actual cost of $25,000 or more must be approved by the Director, VR&E Service. (Authority: 38 U.S.C. 3104... Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of...

  11. Plastic Response of Tracheids in Pinus pinaster in a Water-Limited Environment: Adjusting Lumen Size instead of Wall Thickness

    PubMed Central

    Carvalho, Ana; Nabais, Cristina; Vieira, Joana; Rossi, Sergio; Campelo, Filipe

    2015-01-01

    The formation of wood results from cambial activity and its anatomical properties reflect the variability of environmental conditions during the growing season. Recently, it was found that wood density variations in conifers growing under cold-limited environment result from the adjustment of cell wall thickness (CWT) to temperature. Additionally, it is known that intra-annual density fluctuations (IADFs) are formed in response to precipitation after the summer drought. Although IADFs are frequent in Mediterranean conifers no study has yet been conducted to determine if these structures result from the adjustment of lumen diameter (LD) or CWT to soil water availability. Our main objective is to investigate the intra-ring variation of wood anatomical features (LD and CWT) in Pinus pinaster Ait. growing under a water-limited environment. We compared the tracheidograms of LD and CWT for the years 2010–2013 in P. pinaster growing in the west coast of Portugal. Our results suggest a close association between LD and soil moisture content along the growing season, reinforcing the role of water availability in determining tracheid size. Compared with CWT, LD showed a higher intra- and inter-annual variability suggesting its strong adjustment value to variations in water availability. The formation of a latewood IADF appears to be predisposed by higher rates of cell production in spring and triggered by early autumn precipitation. Our findings reinforce the crucial role of water availability on cambial activity and wood formation in Mediterranean conifers, and emphasize the high plasticity of wood anatomical features under Mediterranean climate. PMID:26305893

  12. 77 FR 75163 - Federal Acquisition Regulation; Information Collection; Contract Funding-Limitation of Costs/Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Regulation; Information Collection; Contract Funding--Limitation of Costs/Funds AGENCIES: Department of... (NASA). ACTION: Notice of request for public comments regarding an extension of an existing OMB...: Submit comments identified by Information Collection 9000- 0074, Contract Funding--Limitation of...

  13. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA clauses for limitation... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall insert...

  14. Impact of work-related cancers in Taiwan-Estimation with QALY (quality-adjusted life year) and healthcare costs.

    PubMed

    Lee, Lukas Jyuhn-Hsiarn; Lin, Cheng-Kuan; Hung, Mei-Chuan; Wang, Jung-Der

    2016-12-01

    This study estimates the annual numbers of eight work-related cancers, total losses of quality-adjusted life years (QALYs), and lifetime healthcare expenditures that possibly could be saved by improving occupational health in Taiwan. Three databases were interlinked: the Taiwan Cancer Registry, the National Mortality Registry, and the National Health Insurance Research Database. Annual numbers of work-related cancers were estimated based on attributable fractions (AFs) abstracted from a literature review. The survival functions for eight cancers were estimated and extrapolated to lifetime using a semi-parametric method. A convenience sample of 8846 measurements of patients' quality of life with EQ-5D was collected for utility values and multiplied by survival functions to estimate quality-adjusted life expectancies (QALEs). The loss-of-QALE was obtained by subtracting the QALE of cancer from age- and sex-matched referents simulated from national vital statistics. The lifetime healthcare expenditures were estimated by multiplying the survival probability with mean monthly costs paid by the National Health Insurance for cancer diagnosis and treatment and summing this for the expected lifetime. A total of 3010 males and 726 females with eight work-related cancers were estimated in 2010. Among them, lung cancer ranked first in terms of QALY loss, with an annual total loss-of-QALE of 28,463 QALYs and total lifetime healthcare expenditures of US$36.6 million. Successful prevention of eight work-related cancers would not only avoid the occurrence of 3736 cases of cancer, but would also save more than US$70 million in healthcare costs and 46,750 QALYs for the Taiwan society in 2010. PMID:27413666

  15. Impact of work-related cancers in Taiwan-Estimation with QALY (quality-adjusted life year) and healthcare costs.

    PubMed

    Lee, Lukas Jyuhn-Hsiarn; Lin, Cheng-Kuan; Hung, Mei-Chuan; Wang, Jung-Der

    2016-12-01

    This study estimates the annual numbers of eight work-related cancers, total losses of quality-adjusted life years (QALYs), and lifetime healthcare expenditures that possibly could be saved by improving occupational health in Taiwan. Three databases were interlinked: the Taiwan Cancer Registry, the National Mortality Registry, and the National Health Insurance Research Database. Annual numbers of work-related cancers were estimated based on attributable fractions (AFs) abstracted from a literature review. The survival functions for eight cancers were estimated and extrapolated to lifetime using a semi-parametric method. A convenience sample of 8846 measurements of patients' quality of life with EQ-5D was collected for utility values and multiplied by survival functions to estimate quality-adjusted life expectancies (QALEs). The loss-of-QALE was obtained by subtracting the QALE of cancer from age- and sex-matched referents simulated from national vital statistics. The lifetime healthcare expenditures were estimated by multiplying the survival probability with mean monthly costs paid by the National Health Insurance for cancer diagnosis and treatment and summing this for the expected lifetime. A total of 3010 males and 726 females with eight work-related cancers were estimated in 2010. Among them, lung cancer ranked first in terms of QALY loss, with an annual total loss-of-QALE of 28,463 QALYs and total lifetime healthcare expenditures of US$36.6 million. Successful prevention of eight work-related cancers would not only avoid the occurrence of 3736 cases of cancer, but would also save more than US$70 million in healthcare costs and 46,750 QALYs for the Taiwan society in 2010.

  16. A prospective comparison of the costs of reusable and limited-reuse laparoscopic instruments

    PubMed Central

    DesCôteaux, Jean-Gaston; Blackmore, Kay; Parsons, Louise

    1998-01-01

    Objective To compare the cost and performance of 2 types of laparoscopic instrumentation: reusable laparoscopic hook cautery instruments and curved scissors, or limited-reuse laparoscopic hook cautery instruments and curved scissors. Design A randomized trial. Setting The operating room of a tertiary care hospital. Method All general surgeons performing laparoscopic procedures at the hospital were randomized to be supplied with either reusable or limited-reuse hook cautery and curved scissors. Instrument use was recorded, together with principal outcome measures. Outcome measures Life expectancy of the instruments, the number of cases for which they were used, the number, nature and cost of repairs, their purchase cost and surgeon satisfaction. Results Reusable hook cautery instruments were less expensive than their limited-reuse counterparts. Excellent surgeon satisfaction was reported with the use of this type of instrument. The limited-reuse curved scissors arm of the study was terminated early because of a breach in study protocol. Conclusions Reusable hook cautery instruments were better than their limited-reuse counterparts. Rigorous attempts to compare the cost of laparoscopic instruments may be limited by their rapid evolution in design and the availability of many types of instruments on the market. PMID:9575997

  17. Adjusting for car occupant injury liability in relation to age, speed limit, and gender-specific driver crash involvement risk.

    PubMed

    Keall, Michael; Frith, William

    2004-12-01

    It is well established that older drivers' fragility is an important factor associated with higher levels of fatal crash involvement for older drivers. There has been less research on age-related fragility with respect to the sort of minor injuries that are more common in injury crashes. This study estimates a quantity that is related to injury fragility: the probability that a driver or a passenger of that driver will be injured in crashes involving two cars. The effects of other factors apart from drivers' fragility are included in this measure, including the fragility of the passengers, the crashworthiness of cars driven, seatbelt use by the occupants, and characteristics of crashes (including configuration and impact speed). The car occupant injury liability estimates appropriately includes these factors to adjust risk curves by age, gender, and speed limit accounting for overrepresentation in crashes associated with fragility and these other factors. PMID:15545071

  18. 34 CFR 373.22 - What are the limitations on indirect costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What are the limitations on indirect costs? 373.22 Section 373.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL DEMONSTRATION PROGRAMS...

  19. 42 CFR 447.206 - Cost limit for providers operated by units of government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Institutional governmentally-operated health care providers (i.e., hospitals, nursing facilities, and ICFs/MR... 42 Public Health 4 2010-10-01 2010-10-01 false Cost limit for providers operated by units of government. 447.206 Section 447.206 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT...

  20. Corporations Eye Limits on Matching Gifts to Colleges as Costs Go Up Almost 200 Pct.

    ERIC Educational Resources Information Center

    Bailey, Anne Lowrey

    1987-01-01

    Many corporations are considering limits on how much they spend to match their employees' gifts to colleges. In response to abuses, corporations and colleges have tightened the administration of matching-gift programs, which in turn has contributed to the increased costs of running them. (MLW)

  1. 48 CFR 3452.232-70 - Limitation of cost or funds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Limitation of cost or funds. 3452.232-70 Section 3452.232-70 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions...

  2. The Impact of Debt Limitations and Referenda Requirements on the Cost of School District Bond Issues

    ERIC Educational Resources Information Center

    Harris, Mary H.; Munley, Vincent G.

    2011-01-01

    One distinction between the markets for corporate and municipal bonds involves institutional constraints that apply to some municipal bond issues. This research focuses on how public finance institutions, in particular explicit debt limits and referenda requirements, affect the borrowing cost of individual school district bond issues. The…

  3. 24 CFR 248.161 - Mandatory sale of housing in excess of the Federal cost limit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of the Federal cost limit. 248.161 Section 248.161 Housing and Urban Development Regulations Relating... UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES PREPAYMENT OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of...

  4. 24 CFR 248.161 - Mandatory sale of housing in excess of the Federal cost limit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of the Federal cost limit. 248.161 Section 248.161 Housing and Urban Development Regulations Relating... UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES PREPAYMENT OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of...

  5. 40 CFR 35.925-18 - Limitation upon project costs incurred prior to award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... eligible land, or advance construction of minor portions of treatment works, including associated... GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.925-18 Limitation upon project costs incurred prior to award. That...

  6. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  7. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  8. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  9. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  10. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  11. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  12. 48 CFR 1832.705-2 - Clauses for limitation of cost or funds.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Clauses for limitation of cost or funds. 1832.705-2 Section 1832.705-2 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding...

  13. 48 CFR 1832.705-2 - Clauses for limitation of cost or funds.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Clauses for limitation of cost or funds. 1832.705-2 Section 1832.705-2 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding...

  14. 48 CFR 1832.705-2 - Clauses for limitation of cost or funds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Clauses for limitation of cost or funds. 1832.705-2 Section 1832.705-2 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding...

  15. 48 CFR 1832.705-2 - Clauses for limitation of cost or funds.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Clauses for limitation of cost or funds. 1832.705-2 Section 1832.705-2 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding...

  16. 48 CFR 1832.705-2 - Clauses for limitation of cost or funds.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Clauses for limitation of cost or funds. 1832.705-2 Section 1832.705-2 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding...

  17. 40 CFR 35.925-18 - Limitation upon project costs incurred prior to award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Limitation upon project costs incurred prior to award. 35.925-18 Section 35.925-18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.925-18...

  18. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  19. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  20. 78 FR 43203 - Federal Acquisition Regulation; Submission for OMB Review; Contract Funding-Limitation of Costs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... Regulation; Submission for OMB Review; Contract Funding--Limitation of Costs/Funds AGENCY: Department of... (NASA). ACTION: Notice of request for public comments regarding an extension of an existing OMB... ] published in the Federal Register at 77 FR 75163, on December 19, 2012. Two comments were received....

  1. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  2. Trade-offs limiting the evolution of coloniality: ecological displacement rates used to measure small costs.

    PubMed

    Yokota, Kiyoko; Sterner, Robert W

    2011-02-01

    Multicellular organisms that benefit from division of labour are presumably descended from colonial species that initially derived benefits from larger colony size, before the evolution of specialization. Life in a colony can have costs as well as benefits, but these can be hard to measure. We measured physiological costs to life in a colony using a novel method based on population dynamics, comparing growth rates of unicells and kairomone-induced colonies of a green alga Desmodesmus subspicatus against a reference co-occurring species. Coloniality negatively affected growth during the initial log growth phase, while no adverse effect was detected under nutrient-limited competitive conditions. The results point to costs associated with traits involved in rapid growth rather than those associated with efficient growth under resource scarcity. Some benefits of coloniality (e.g. defence from herbivory) may be different from when this trait evolved, but our approach shows how costs would have depended on conditions.

  3. Trade-offs limiting the evolution of coloniality: ecological displacement rates used to measure small costs

    PubMed Central

    Yokota, Kiyoko; Sterner, Robert W.

    2011-01-01

    Multicellular organisms that benefit from division of labour are presumably descended from colonial species that initially derived benefits from larger colony size, before the evolution of specialization. Life in a colony can have costs as well as benefits, but these can be hard to measure. We measured physiological costs to life in a colony using a novel method based on population dynamics, comparing growth rates of unicells and kairomone-induced colonies of a green alga Desmodesmus subspicatus against a reference co-occurring species. Coloniality negatively affected growth during the initial log growth phase, while no adverse effect was detected under nutrient-limited competitive conditions. The results point to costs associated with traits involved in rapid growth rather than those associated with efficient growth under resource scarcity. Some benefits of coloniality (e.g. defence from herbivory) may be different from when this trait evolved, but our approach shows how costs would have depended on conditions. PMID:20739317

  4. Recent proposals to limit Medigap coverage and modify Medicare cost sharing.

    PubMed

    Linehan, Kathryn

    2012-02-24

    As policymakers look for savings from the Medicare program, some have proposed eliminating or discouraging "first-dollar coverage" available through privately purchased Medigap policies. Medigap coverage, which beneficiaries obtain to protect themselves from Medicare's cost-sharing requirements and its lack of a cap on out-of-pocket spending, may discourage the judicious use of medical services by reducing or eliminating beneficiary cost sharing. It is estimated that eliminating such coverage, which has been shown to be associated with higher Medicare spending, and requiring some cost sharing would encourage beneficiaries to reduce their service use and thus reduce pro­gram spending. However, eliminating first-dollar coverage could cause some beneficiaries to incur higher spending or forego necessary services. Some policy proposals to eliminate first-dollar coverage would also modify Medicare's cost sharing and add an out-of-pocket spending cap for fee-for-service Medicare. This paper discusses Medicare's current cost-sharing requirements, Medigap insurance, and proposals to modify Medicare's cost sharing and eliminate first-dollar coverage in Medigap plans. It reviews the evidence on the effects of first-dollar coverage on spending, some objections to eliminating first-dollar coverage, and results of research that has modeled the impact of eliminating first-dollar coverage, modifying Medicare's cost-sharing requirements, and adding an out-of-pocket limit on beneficiaries' spending.

  5. Economic valuation through cost-benefit analysis--possibilities and limitations.

    PubMed

    Hansjürgens, Bernd

    2004-12-15

    The economic approach used to evaluate effects on human health and the environment centres around cost-benefit analysis (CBA). Thus, for most economists, economic valuation and CBA are one and the same. However, the question of the possibilities and limitations of cost-benefit analysis is one of the most controversial aspects of environmental research. In this paper, the possibilities and limitations of CBA are analysed. This is done not only by explaining the central elements of CBA, but also by commenting on criticism of it. What becomes clear is that CBA is not only a mere mechanism of monetarisation, but a heuristic model for the whole process of valuation. It can serve as a guideline for collecting the necessary data in a systematic way. The limits of CBA can be mainly seen in the non-substitutability of essential goods, irreversibility, long-term effects and inter-generational fairness.

  6. 45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Your share of member support costs must be non-Federal cash. (4) The Corporation's share of health care...'s share of program costs? 2521.45 Section 2521.45 Public Welfare Regulations Relating to Public... limitations on the Federal government's share of program costs? The limitations on the Federal...

  7. 45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Your share of member support costs must be non-Federal cash. (4) The Corporation's share of health care...'s share of program costs? 2521.45 Section 2521.45 Public Welfare Regulations Relating to Public... limitations on the Federal government's share of program costs? The limitations on the Federal...

  8. The Cost-Effectiveness of Repeat HIV Testing During Pregnancy in a Resource-Limited Setting

    PubMed Central

    Kim, Lena H.; Cohan, Deborah L.; Sparks, Teresa N.; Pilliod, Rachel A.; Arinaitwe, Emmanuel; Caughey, Aaron B.

    2013-01-01

    OBJECTIVE To estimate the cost-effectiveness of HIV screening strategies for the prevention of perinatal transmission in Uganda, a resource-limited country with high HIV prevalence and incidence. STUDY DESIGN We designed a decision-analytic model from a health care system perspective to assess the vertical transmission rates and cost-effectiveness of four different HIV screening strategies in pregnancy: 1) Rapid HIV antibody (Ab) test at initial visit (current standard of care); 2) Strategy 1 + HIV RNA at initial visit (adds detection of acute HIV); 3) Strategy 1 + repeat HIV Ab at delivery (adds detection of incident HIV); 4) Strategy 3 + HIV RNA at delivery (adds detection of acute HIV at delivery). Model estimates were derived from the literature and local sources, and life years saved were discounted at a rate of 3% per year. Based on World Health Organization guidelines, we defined our cost-effectiveness threshold as ≤3 times the gross domestic product per capita, which for Uganda was US$3300 in 2008. RESULTS Using base case estimates of 10% HIV prevalence among women entering prenatal care and 3% incidence during pregnancy, strategy 3 was incrementally the cost-effective option that led to the greatest total life years. CONCLUSION Repeat rapid HIV Ab testing at the time of labor is a cost-effective strategy even in a resource-limited setting such as Uganda. PMID:23392461

  9. When does female multiple mating evolve to adjust inbreeding? Effects of inbreeding depression, direct costs, mating constraints, and polyandry as a threshold trait.

    PubMed

    Duthie, A Bradley; Bocedi, Greta; Reid, Jane M

    2016-09-01

    Polyandry is often hypothesized to evolve to allow females to adjust the degree to which they inbreed. Multiple factors might affect such evolution, including inbreeding depression, direct costs, constraints on male availability, and the nature of polyandry as a threshold trait. Complex models are required to evaluate when evolution of polyandry to adjust inbreeding is predicted to arise. We used a genetically explicit individual-based model to track the joint evolution of inbreeding strategy and polyandry defined as a polygenic threshold trait. Evolution of polyandry to avoid inbreeding only occurred given strong inbreeding depression, low direct costs, and severe restrictions on initial versus additional male availability. Evolution of polyandry to prefer inbreeding only occurred given zero inbreeding depression and direct costs, and given similarly severe restrictions on male availability. However, due to its threshold nature, phenotypic polyandry was frequently expressed even when strongly selected against and hence maladaptive. Further, the degree to which females adjusted inbreeding through polyandry was typically very small, and often reflected constraints on male availability rather than adaptive reproductive strategy. Evolution of polyandry solely to adjust inbreeding might consequently be highly restricted in nature, and such evolution cannot necessarily be directly inferred from observed magnitudes of inbreeding adjustment. PMID:27464756

  10. When does female multiple mating evolve to adjust inbreeding? Effects of inbreeding depression, direct costs, mating constraints, and polyandry as a threshold trait

    PubMed Central

    Duthie, A. Bradley; Bocedi, Greta; Reid, Jane M.

    2016-01-01

    Polyandry is often hypothesized to evolve to allow females to adjust the degree to which they inbreed. Multiple factors might affect such evolution, including inbreeding depression, direct costs, constraints on male availability, and the nature of polyandry as a threshold trait. Complex models are required to evaluate when evolution of polyandry to adjust inbreeding is predicted to arise. We used a genetically explicit individual‐based model to track the joint evolution of inbreeding strategy and polyandry defined as a polygenic threshold trait. Evolution of polyandry to avoid inbreeding only occurred given strong inbreeding depression, low direct costs, and severe restrictions on initial versus additional male availability. Evolution of polyandry to prefer inbreeding only occurred given zero inbreeding depression and direct costs, and given similarly severe restrictions on male availability. However, due to its threshold nature, phenotypic polyandry was frequently expressed even when strongly selected against and hence maladaptive. Further, the degree to which females adjusted inbreeding through polyandry was typically very small, and often reflected constraints on male availability rather than adaptive reproductive strategy. Evolution of polyandry solely to adjust inbreeding might consequently be highly restricted in nature, and such evolution cannot necessarily be directly inferred from observed magnitudes of inbreeding adjustment. PMID:27464756

  11. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... occupation, operation and maintenance of program component space, including utilities. (d) Dual benefit costs. (1) Some costs benefit both the program components as well as development and administrative... occupying, operating and maintaining space. (c) Program costs. Program costs include, but are not limited...

  12. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... occupation, operation and maintenance of program component space, including utilities. (d) Dual benefit costs. (1) Some costs benefit both the program components as well as development and administrative... occupying, operating and maintaining space. (c) Program costs. Program costs include, but are not limited...

  13. Photosynthesis of temperate Eucalyptus globulus trees outside their native range has limited adjustment to elevated CO2 and climate warming.

    PubMed

    Crous, Kristine Y; Quentin, Audrey G; Lin, Yan-Shih; Medlyn, Belinda E; Williams, David G; Barton, Craig V M; Ellsworth, David S

    2013-12-01

    Eucalyptus species are grown widely outside of their native ranges in plantations on all vegetated continents of the world. We predicted that such a plantation species would show high potential for acclimation of photosynthetic traits across a wide range of growth conditions, including elevated [CO2] and climate warming. To test this prediction, we planted temperate Eucalyptus globulus Labill. seedlings in climate-controlled chambers in the field located >700 km closer to the equator than the nearest natural occurrence of this species. Trees were grown in a complete factorial combination of elevated CO2 concentration (eC; ambient [CO2] +240 ppm) and air warming treatments (eT; ambient +3 °C) for 15 months until they reached ca. 10 m height. There was little acclimation of photosynthetic capacity to eC and hence the CO2-induced photosynthetic enhancement was large (ca. 50%) in this treatment during summer. The warming treatment significantly increased rates of both carboxylation capacity (V(cmax)) and electron transport (Jmax) (measured at a common temperature of 25 °C) during winter, but decreased them significantly by 20-30% in summer. The photosynthetic CO2 compensation point in the absence of dark respiration (Γ*) was relatively less sensitive to temperature in this temperate eucalypt species than for warm-season tobacco. The temperature optima for photosynthesis and Jmax significantly changed by about 6 °C between winter and summer, but without further adjustment from early to late summer. These results suggest that there is an upper limit for the photosynthetic capacity of E. globulus ssp. globulus outside its native range to acclimate to growth temperatures above 25 °C. Limitations to temperature acclimation of photosynthesis in summer may be one factor that defines climate zones where E. globulus plantation productivity can be sustained under anticipated global environmental change.

  14. The evolution of cost efficient swimming in marine mammals: limits to energetic optimization

    PubMed Central

    Williams, T. M.

    1999-01-01

    Mammals re-entered the oceans less than 60 million years ago. The transition from a terrestrial to an aquatic lifestyle required extreme morphological and behavioural modifications concomitant with fundamentally different locomotor mechanisms for moving on land and through water. Energetic transport costs typically reflect such different locomotor modes, but can not be discerned from the fossil record. In this study the energetic challenges associated with changing from terrestrial to aquatic locomotion in primitive marine mammals are examined by comparing the transport, maintenance and locomotor costs of extant mammals varying in degree of aquatic specialization. The results indicate that running and swimming specialists have converged on an energetic optimum for locomotion. An allometric expression, COTTOT = 7.79 mass-0.29 (r2 = 0.83, n = 6 species), describes the total cost of transport in J kg-1m-1 for swimming marine mammals ranging in size from 21 kg to 15,000 kg. This relation is indistinguishable from that describing total transport costs in running mammals. In contrast, the transitional lifestyle of semi-aquatic mammals, similar to that of ancestral marine mammals, incurs costs that are 2.4 to 5.1 times higher than locomotor specialists. These patterns suggest that primitive marine mammals confronted an energetic hurdle before returning to costs reminiscent of their terrestrial ancestry, and may have reached an evolutionary limit for energetic optimization during swimming.

  15. 45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are the limitations on the Federal government... limitations on the Federal government's share of program costs? The limitations on the Federal government's... support: The Federal share, including Corporation and other Federal funds, of member support costs,...

  16. 45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false What are the limitations on the Federal government... limitations on the Federal government's share of program costs? The limitations on the Federal government's... support: The Federal share, including Corporation and other Federal funds, of member support costs,...

  17. 75 FR 750 - Consumer Price Index Adjustments of Oil Pollution Act of 1990 Limits of Liability-Vessels and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-06

    ...--Vessels and Deepwater Ports'' (73 FR 54997) CPI-U Consumer Price Index--All Urban Consumers, Not... Federal Register, at 73 FR 54997, entitled ``Consumer Price Index Adjustments of Oil Pollution Act of 1990... SECURITY Coast Guard 33 CFR Part 138 RIN 1625-AB25 Consumer Price Index Adjustments of Oil Pollution......

  18. The relationship between effectiveness and costs measured by a risk-adjusted case-mix system: multicentre study of Catalonian population data bases

    PubMed Central

    Sicras-Mainar, Antoni; Navarro-Artieda, Ruth; Blanca-Tamayo, Milagrosa; Velasco-Velasco, Soledad; Escribano-Herranz, Esperanza; Llopart-López, Josep Ramon; Violan-Fors, Concepción; Vilaseca-Llobet, Josep Maria; Sánchez-Fontcuberta, Encarna; Benavent-Areu, Jaume; Flor-Serra, Ferran; Aguado-Jodar, Alba; Rodríguez-López, Daniel; Prados-Torres, Alejandra; Estelrich-Bennasar, Jose

    2009-01-01

    Background The main objective of this study is to measure the relationship between morbidity, direct health care costs and the degree of clinical effectiveness (resolution) of health centres and health professionals by the retrospective application of Adjusted Clinical Groups in a Spanish population setting. The secondary objectives are to determine the factors determining inadequate correlations and the opinion of health professionals on these instruments. Methods/Design We will carry out a multi-centre, retrospective study using patient records from 15 primary health care centres and population data bases. The main measurements will be: general variables (age and sex, centre, service [family medicine, paediatrics], and medical unit), dependent variables (mean number of visits, episodes and direct costs), co-morbidity (Johns Hopkins University Adjusted Clinical Groups Case-Mix System) and effectiveness. The totality of centres/patients will be considered as the standard for comparison. The efficiency index for visits, tests (laboratory, radiology, others), referrals, pharmaceutical prescriptions and total will be calculated as the ratio: observed variables/variables expected by indirect standardization. The model of cost/patient/year will differentiate fixed/semi-fixed (visits) costs of the variables for each patient attended/year (N = 350,000 inhabitants). The mean relative weights of the cost of care will be obtained. The effectiveness will be measured using a set of 50 indicators of process, efficiency and/or health results, and an adjusted synthetic index will be constructed (method: percentile 50). The correlation between the efficiency (relative-weights) and synthetic (by centre and physician) indices will be established using the coefficient of determination. The opinion/degree of acceptance of physicians (N = 1,000) will be measured using a structured questionnaire including various dimensions. Statistical analysis: multiple regression analysis (procedure

  19. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL TANF PROVISIONS Tribal TANF Funding... administrative cost cap, even if they fall within the definition of “administrative costs.” (c)...

  20. Parental Psychological Autonomy and Children's Academic Competence and Behavioral Adjustment in Late Childhood: More than just Limit-Setting and Warmth.

    ERIC Educational Resources Information Center

    Mattanah, Jonathan F.

    2001-01-01

    Examined links between 91 fourth graders' academic competence and behavioral adjustment and mothers' and fathers' psychological autonomy, controlling for effects of parental limit-setting and warmth. Found that fathers' psychological autonomy was a unique correlate to greater academic competence and fewer signs of depression in the classroom,…

  1. Delivering pediatric HIV care in resource-limited settings: cost considerations in an expanded response.

    PubMed

    Tolle, Michael A; Phelps, B Ryan; Desmond, Chris; Sugandhi, Nandita; Omeogu, Chinyere; Jamieson, David; Ahmed, Saeed; Reuben, Elan; Muhe, Lulu; Kellerman, Scott E

    2013-11-01

    If children are to be protected from HIV, the expansion of PMTCT programs must be complemented by increased provision of paediatric treatment. This is expensive, yet there are humanitarian, equity and children's rights arguments to justify the prioritization of treating HIV-infected children. In the context of limited budgets, inefficiencies cost lives, either through lower coverage or less effective services. With the goal of informing the design and expansion of efficient paediatric treatment programs able to utilize to greatest effect the available resources allocated to the treatment of HIV-infected children, this article reviews what is known about cost drivers in paediatric HIV interventions, and makes suggestions for improving efficiency in paediatric HIV programming. High-impact interventions known to deliver disproportional returns on investment are highlighted and targeted for immediate scale-up. Progress will carry a cost - increased funding, as well as additional data on intervention costs and outcomes, will be required if universal access of HIV-infected children to treatment is to be achieved and sustained. PMID:24361627

  2. Delivering pediatric HIV care in resource-limited settings: cost considerations in an expanded response.

    PubMed

    Tolle, Michael A; Phelps, B Ryan; Desmond, Chris; Sugandhi, Nandita; Omeogu, Chinyere; Jamieson, David; Ahmed, Saeed; Reuben, Elan; Muhe, Lulu; Kellerman, Scott E

    2013-11-01

    If children are to be protected from HIV, the expansion of PMTCT programs must be complemented by increased provision of paediatric treatment. This is expensive, yet there are humanitarian, equity and children's rights arguments to justify the prioritization of treating HIV-infected children. In the context of limited budgets, inefficiencies cost lives, either through lower coverage or less effective services. With the goal of informing the design and expansion of efficient paediatric treatment programs able to utilize to greatest effect the available resources allocated to the treatment of HIV-infected children, this article reviews what is known about cost drivers in paediatric HIV interventions, and makes suggestions for improving efficiency in paediatric HIV programming. High-impact interventions known to deliver disproportional returns on investment are highlighted and targeted for immediate scale-up. Progress will carry a cost - increased funding, as well as additional data on intervention costs and outcomes, will be required if universal access of HIV-infected children to treatment is to be achieved and sustained.

  3. Limited By Cost: The Case Against Humans In The Scientific Exploration Of Space

    NASA Astrophysics Data System (ADS)

    Coates, Andrew J.

    2001-11-01

    Human space flight represents a heady mix of bravery and drama which can be inspirational to nations and to humankind but at huge economic cost. Due to the current high launch costs only a handful of people have ventured beyond low Earth orbit and walked on the Moon, propelled by aspirations related more to the Cold War than to science. Problems with reusable launch vehicle development mean that severe launch cost limitations will exist for some time. Meanwhile, cheaper robotic probes have visited all the planets except Pluto, flown by comets, landed on Mars, Venus and an asteroid, have probed Jupiter's atmosphere and studied the Universe beyond our own solar system with telescopes. Using these data we are determining mankind's place in the Universe. Public interest in the historic Eros landing eclipsed a simultaneous space walk at the fledgling International Space Station and the Mars Pathfinder landing generated hundreds of millions of website hits in a few days. Given the fact that hundreds of Mars missions could be flown for the still-escalating cost of the International Space Station, the unsuitability of human bodies for deep space exploration, and the advances in 3-d and virtual reality techniques, we discuss whether human exploration needs a place in a realistic, useful and inspirational space programme.

  4. 10 CFR 719.32 - For what costs is the contractor, or Department retained counsel, limited to reimbursement of...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false For what costs is the contractor, or Department retained counsel, limited to reimbursement of actual costs only? 719.32 Section 719.32 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS Reimbursement of Costs Subject to This Part § 719.32 For what...

  5. 20 CFR 667.210 - What administrative cost limits apply to Workforce Investment Act title I grants?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Workforce Investment Act title I grants? 667.210 Section 667.210 Employees' Benefits EMPLOYMENT AND TRAINING... INVESTMENT ACT Administrative Rules, Costs and Limitations § 667.210 What administrative cost limits apply to Workforce Investment Act title I grants? (a) Formula grants to States: (1) As part of the 15 percent that...

  6. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Limitations on costs of development and... Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE... and General Administration § 1301.32 Limitations on costs of development and administration of a...

  7. Cost-appropriateness of whole body vs limited bone imaging for suspected focal sports injuries

    SciTech Connect

    Nagle, C.E.

    1986-07-01

    Bone imaging has been recognized as a useful diagnostic tool in detecting the presence of focal musculoskeletal injury when radiographs are normal. A retrospective review of bone images in a small number of amateur athletes indicates that secondary injuries were commonly detected at sites different from the site of musculoskeletal pain being evaluated for injury. While a larger study will be necessary to confirm the data, this review suggests that it is medically justified and cost-appropriate to perform imaging of the entire skeleton as opposed to imaging limited to the anatomic site of pain and suspected injury.

  8. Cost of a quality-adjusted life year in liver transplantation: the influence of the indication and the model for end-stage liver disease score.

    PubMed

    Åberg, Fredrik; Mäklin, Suvi; Räsänen, Pirjo; Roine, Risto P; Sintonen, Harri; Koivusalo, Anna-Maria; Höckerstedt, Krister; Isoniemi, Helena

    2011-11-01

    Cost issues in liver transplantation (LT) have received increasing attention, but the cost-utility is rarely calculated. We compared costs per quality-adjusted life year (QALY) from the time of placement on the LT waiting list to 1 year after transplantation for 252 LT patients and to 5 years after transplantation for 81 patients. We performed separate calculations for chronic liver disease (CLD), acute liver failure (ALF), and different Model for End-Stage Liver Disease (MELD) scores. For the estimation of QALYs, the health-related quality of life was measured with the 15D instrument. The median costs and QALYs after LT were €141,768 and 0.895 for 1 year and €177,618 and 3.960 for 5 years, respectively. The costs of the first year were 80% of the 5-year costs. The main cost during years 2 to 5 was immunosuppression drugs (59% of the annual costs). The cost/QALY ratio improved from €158,400/QALY at 1 year to €44,854/QALY at 5 years, and the ratio was more beneficial for CLD patients (€42,500/QALY) versus ALF patients (€63,957/QALY) and for patients with low MELD scores versus patients with high MELD scores. Although patients with CLD and MELD scores > 25 demonstrated markedly higher 5-year costs (€228,434) than patients with MELD scores < 15 (€169,541), the cost/QALY difference was less pronounced (€59,894/QALY and €41,769/QALY, respectively). The cost/QALY ratio for LT appears favorable, but it is dependent on the assessed time period and the severity of the liver disease.

  9. Processing power limits social group size: computational evidence for the cognitive costs of sociality.

    PubMed

    Dávid-Barrett, T; Dunbar, R I M

    2013-08-22

    Sociality is primarily a coordination problem. However, the social (or communication) complexity hypothesis suggests that the kinds of information that can be acquired and processed may limit the size and/or complexity of social groups that a species can maintain. We use an agent-based model to test the hypothesis that the complexity of information processed influences the computational demands involved. We show that successive increases in the kinds of information processed allow organisms to break through the glass ceilings that otherwise limit the size of social groups: larger groups can only be achieved at the cost of more sophisticated kinds of information processing that are disadvantageous when optimal group size is small. These results simultaneously support both the social brain and the social complexity hypotheses.

  10. Processing power limits social group size: computational evidence for the cognitive costs of sociality

    PubMed Central

    Dávid-Barrett, T.; Dunbar, R. I. M.

    2013-01-01

    Sociality is primarily a coordination problem. However, the social (or communication) complexity hypothesis suggests that the kinds of information that can be acquired and processed may limit the size and/or complexity of social groups that a species can maintain. We use an agent-based model to test the hypothesis that the complexity of information processed influences the computational demands involved. We show that successive increases in the kinds of information processed allow organisms to break through the glass ceilings that otherwise limit the size of social groups: larger groups can only be achieved at the cost of more sophisticated kinds of information processing that are disadvantageous when optimal group size is small. These results simultaneously support both the social brain and the social complexity hypotheses. PMID:23804623

  11. Plant process computer replacements - techniques to limit installation schedules and costs

    SciTech Connect

    Baker, M.D.; Olson, J.L. )

    1992-01-01

    Plant process computer systems, a standard fixture in all nuclear power plants, are used to monitor and display important plant process parameters. Scanning thousands of field sensors and alarming out-of-limit values, these computer systems are heavily relied on by control room operators. The original nuclear steam supply system (NSSS) vendor for the power plant often supplied the plant process computer. Designed using sixties and seventies technology, a plant's original process computer has been obsolete for some time. Driven by increased maintenance costs and new US Nuclear Regulatory Commission regulations such as NUREG-0737, Suppl. 1, many utilities have replaced their process computers with more modern computer systems. Given that computer systems are by their nature prone to rapid obsolescence, this replacement cycle will likely repeat. A process computer replacement project can be a significant capital expenditure and must be performed during a scheduled refueling outage. The object of the installation process is to install a working system on schedule. Experience gained by supervising several computer replacement installations has taught lessons that, if applied, will shorten the schedule and limit the risk of costly delays. Examples illustrating this technique are given. This paper and these examples deal only with the installation process and assume that the replacement computer system has been adequately designed, and development and factory tested.

  12. Initial investigation into lower-cost CT for resource limited regions of the world

    NASA Astrophysics Data System (ADS)

    Dobbins, James T., III; Wells, Jered R.; Segars, W. Paul; Li, Christina M.; Kigongo, Christopher J. N.

    2010-04-01

    This paper describes an initial investigation into means for producing lower-cost CT scanners for resource limited regions of the world. In regions such as sub-Saharan Africa, intermediate level medical facilities serving millions have no CT machines, and lack the imaging resources necessary to determine whether certain patients would benefit from being transferred to a hospital in a larger city for further diagnostic workup or treatment. Low-cost CT scanners would potentially be of immense help to the healthcare system in such regions. Such scanners would not produce state-of-theart image quality, but rather would be intended primarily for triaging purposes to determine the patients who would benefit from transfer to larger hospitals. The lower-cost scanner investigated here consists of a fixed digital radiography system and a rotating patient stage. This paper describes initial experiments to determine if such a configuration is feasible. Experiments were conducted using (1) x-ray image acquisition, a physical anthropomorphic chest phantom, and a flat-panel detector system, and (2) a computer-simulated XCAT chest phantom. Both the physical phantom and simulated phantom produced excellent image quality reconstructions when the phantom was perfectly aligned during acquisition, but artifacts were noted when the phantom was displaced to simulate patient motion. An algorithm was developed to correct for motion of the phantom and demonstrated success in correcting for 5-mm motion during 360-degree acquisition of images. These experiments demonstrated feasibility for this approach, but additional work is required to determine the exact limitations produced by patient motion.

  13. Fitness costs limit the development of resistance to indoxacarb and deltamethrin in Heliothis virescens (Lepidoptera: Noctuidae).

    PubMed

    Sayyed, Ali H; Ahmad, Munir; Crickmore, Neil

    2008-12-01

    Insecticide resistance in Heliothis virescens (F.) (Lepidoptera: Noctuidae) has been documented from all over the world and is often associated with reduced fitness. Fitness costs could delay the development of resistance depending upon the prevailing conditions. We were interested in establishing whether a field-collected population from Washington County, MS, was resistant to spinosad, indoxacarb, and deltamethrin and whether any such resistance was associated with fitness costs. Bioassays results showed that the insecticides were equally toxic to the field population. Upon laboratory selection (generations [G]3 to G8), the resistance ratio increased only 2-, 3-, and 1-fold for spinosad, deltamethrin, and indoxacarb, respectively, compared with the field population. In contrast, the resistance ratios increased 213-, 65-, and 55-fold compared with an unselected population at G9. The estimated realized heritability (h2) after six generations of selection was 0.17, 0.03, and 0.12, respectively, and the number of generations required for 10-fold increase in LC50 of Spino-SEL, Indoxa-SEL, and Delta-SEL was estimated to be 14.3, 50, and 14.3. Comparison of life traits between the selected and unselected populations revealed that the selected populations laid a significantly lower number of eggs and that a lower percentage of eggs hatched. This also was reflected in both the net replacement rate and the intrinsic rate of population increase, which were both lower for the selected populations. It also was observed that the mean relative growth rate of the larvae was lower for the selected populations; not only did the larvae take longer to pupate but the mean weight of the prepupae from the selected populations was lower. Our data suggest that due to fitness costs the development of resistance to the insecticides was limited such that after six generations of selection the larvae were no less susceptible to the insecticides than the field population although were

  14. 20 CFR 667.210 - What administrative cost limits apply to Workforce Investment Act title I grants?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... limited to no more than ten percent (10%) of the amount allocated to the local area under sections 128(b... for Statewide administrative costs nor the ten percent (10%) of the amount allotted that may...

  15. Dynamically Adjustable Wind Turbine Blades: Adaptive Turbine Blades, Blown Wing Technology for Low-Cost Wind Power

    SciTech Connect

    2010-02-02

    Broad Funding Opportunity Announcement Project: Caitin is developing wind turbines with a control system that delivers compressed air from special slots located in the surface of its blades. The compressed air dynamically adjusts the aerodynamic performance of the blades, and can essentially be used to control lift, drag, and ultimately power. This control system has been shown to exhibit high levels of control in combination with an exceptionally fast response rate. The deployment of such a control system in modern wind turbines would lead to better management of the load on the system during peak usage, allowing larger blades to be deployed with a resulting increase in energy production.

  16. A limit-cycle model of leg movements in cross-country skiing and its adjustments with fatigue.

    PubMed

    Cignetti, F; Schena, F; Mottet, D; Rouard, A

    2010-08-01

    Using dynamical modeling tools, the aim of the study was to establish a minimal model reproducing leg movements in cross-country skiing, and to evaluate the eventual adjustments of this model with fatigue. The participants (N=8) skied on a treadmill at 90% of their maximal oxygen consumption, up to exhaustion, using the diagonal stride technique. Qualitative analysis of leg kinematics portrayed in phase planes, Hooke planes, and velocity profiles suggested the inclusion in the model of a linear stiffness and an asymmetric van der Pol-type nonlinear damping. Quantitative analysis revealed that this model reproduced the observed kinematics patterns of the leg with adequacy, accounting for 87% of the variance. A rising influence of the stiffness term and a dropping influence of the damping terms were also evidenced with fatigue. The meaning of these changes was discussed in the framework of motor control.

  17. The Cost-Effectiveness of Monitoring Strategies for Antiretroviral Therapy of HIV Infected Patients in Resource-Limited Settings: Software Tool

    PubMed Central

    Estill, Janne; Salazar-Vizcaya, Luisa; Blaser, Nello; Egger, Matthias; Keiser, Olivia

    2015-01-01

    Background The cost-effectiveness of routine viral load (VL) monitoring of HIV-infected patients on antiretroviral therapy (ART) depends on various factors that differ between settings and across time. Low-cost point-of-care (POC) tests for VL are in development and may make routine VL monitoring affordable in resource-limited settings. We developed a software tool to study the cost-effectiveness of switching to second-line ART with different monitoring strategies, and focused on POC-VL monitoring. Methods We used a mathematical model to simulate cohorts of patients from start of ART until death. We modeled 13 strategies (no 2nd-line, clinical, CD4 (with or without targeted VL), POC-VL, and laboratory-based VL monitoring, with different frequencies). We included a scenario with identical failure rates across strategies, and one in which routine VL monitoring reduces the risk of failure. We compared lifetime costs and averted disability-adjusted life-years (DALYs). We calculated incremental cost-effectiveness ratios (ICER). We developed an Excel tool to update the results of the model for varying unit costs and cohort characteristics, and conducted several sensitivity analyses varying the input costs. Results Introducing 2nd-line ART had an ICER of US$1651-1766/DALY averted. Compared with clinical monitoring, the ICER of CD4 monitoring was US$1896-US$5488/DALY averted and VL monitoring US$951-US$5813/DALY averted. We found no difference between POC- and laboratory-based VL monitoring, except for the highest measurement frequency (every 6 months), where laboratory-based testing was more effective. Targeted VL monitoring was on the cost-effectiveness frontier only if the difference between 1st- and 2nd-line costs remained large, and if we assumed that routine VL monitoring does not prevent failure. Conclusion Compared with the less expensive strategies, the cost-effectiveness of routine VL monitoring essentially depends on the cost of 2nd-line ART. Our Excel tool is

  18. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... subject to the limit determined under § 286.50. (b) Information technology and computerization for..., administering, monitoring, and controlling a sample are not inherent parts of information technology...

  19. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... subject to the limit determined under § 286.50. (b) Information technology and computerization for..., administering, monitoring, and controlling a sample are not inherent parts of information technology...

  20. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... subject to the limit determined under § 286.50. (b) Information technology and computerization for..., administering, monitoring, and controlling a sample are not inherent parts of information technology...

  1. The Costs of Delivering Integrated HIV and Sexual Reproductive Health Services in Limited Resource Settings

    PubMed Central

    Obure, Carol Dayo; Sweeney, Sedona; Darsamo, Vanessa; Michaels-Igbokwe, Christine; Guinness, Lorna; Terris-Prestholt, Fern; Muketo, Esther; Nhlabatsi, Zelda; Warren, Charlotte E.; Mayhew, Susannah; Watts, Charlotte; Vassall, Anna

    2015-01-01

    Objective To present evidence on the total costs and unit costs of delivering six integrated sexual reproductive health and HIV services in a high and medium HIV prevalence setting, in order to support policy makers and planners scaling up these essential services. Design A retrospective facility based costing study conducted in 40 non-government organization and public health facilities in Kenya and Swaziland. Methods Economic and financial costs were collected retrospectively for the year 2010/11, from each study site with an aim to estimate the cost per visit of six integrated HIV and SRH services. A full cost analysis using a combination of bottom-up and step-down costing methods was conducted from the health provider’s perspective. The main unit of analysis is the economic unit cost per visit for each service. Costs are converted to 2013 International dollars. Results The mean cost per visit for the HIV/SRH services ranged from $Int 14.23 (PNC visit) to $Int 74.21 (HIV treatment visit). We found considerable variation in the unit costs per visit across settings with family planning services exhibiting the least variation ($Int 6.71-52.24) and STI treatment and HIV treatment visits exhibiting the highest variation in unit cost ranging from ($Int 5.44-281.85) and ($Int 0.83-314.95), respectively. Unit costs of visits were driven by fixed costs while variability in visit costs across facilities was explained mainly by technology used and service maturity. Conclusion For all services, variability in unit costs and cost components suggest that potential exists to reduce costs through better use of both human and capital resources, despite the high proportion of expenditure on drugs and medical supplies. Further work is required to explore the key drivers of efficiency and interventions that may facilitate efficiency improvements. PMID:25933414

  2. Cost-effectiveness analysis of dialysis and kidney transplant in patients with renal impairment using disability adjusted life years in Iran

    PubMed Central

    YaghoubiFard, Safiye; Goudarzi, Reza; Etminan, Abbas; Baneshi, MohammadReza; Barouni, Mohsen; Jafari Sirizi, Mohammad

    2016-01-01

    Background: This cross-sectional study was conducted to compare the cost-effectiveness of three therapeutic methods of long-term hemodialysis, kidney transplant from a living person and kidney transplant from a cadaver utilizing Disability Adjusted Life Years (DALY) using data from the records of patients referred to Afzalipour Hospital of Kerman in 2012. Methods: This cross-sectional study utilizing Disability Adjusted Life Years (DALY) as outcome measure, used data from the records of patients referred to Afzalipour Hospital of Kerman in 2012. The decision tree model and decision tree software (Tree Age pro 11) were used for data analysis. In this research, costs and effects were studied from the patients and healthcare providers’ perspective. Results: In the patient’s perspective, the CER of dialysis was 5.04 times greater than transplant from a living person and 6.15 times higher than transplant from a cadaveric donor. In the hospital’s perspective, the average cost-effectiveness ratio of dialysis was 8.4 times greater than transplant from a living person and 14.07 times higher than transplant from a cadaver. The smaller the C-E ratio, the greater was the cost-effectiveness. In both perspectives, the order of effectiveness of treatment methods were transplant from a cadaver, transplant from a living person and dialysis. Conclusion: Considering the results obtained in this study, measures should be taken to increase the desire for organ donation from brain-dead patients, living people and patients’ relatives PMID:27493934

  3. Design of a cost-effective, hemodynamically adjustable model for resuscitative endovascular balloon occlusion of the aorta (REBOA) simulation.

    PubMed

    Keller, Benjamin A; Salcedo, Edgardo S; Williams, Timothy K; Neff, Lucas P; Carden, Anthony J; Li, Yiran; Gotlib, Oren; Tran, Nam K; Galante, Joseph M

    2016-09-01

    Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an adjunct technique for salvaging patients with noncompressible torso hemorrhage. Current REBOA training paradigms require large animals, virtual reality simulators, or human cadavers for acquisition of skills. These training strategies are expensive and resource intensive, which may prevent widespread dissemination of REBOA. We have developed a low-cost, near-physiologic, pulsatile REBOA simulator by connecting an anatomic vascular circuit constructed out of latex and polyvinyl chloride tubing to a commercially available pump. This pulsatile simulator is capable of generating cardiac outputs ranging from 1.7 to 6.8 L/min with corresponding arterial blood pressures of 54 to 226/14 to 121 mmHg. The simulator accommodates a 12 French introducer sheath and a CODA balloon catheter. Upon balloon inflation, the arterial waveform distal to the occlusion flattens, distal pulsation within the simulator is lost, and systolic blood pressures proximal to the balloon catheter increase by up to 62 mmHg. Further development and validation of this simulator will allow for refinement, reduction, and replacement of large animal models, costly virtual reality simulators, and perfused cadavers for training purposes. This will ultimately facilitate the low-cost, high-fidelity REBOA simulation needed for the widespread dissemination of this life-saving technique. PMID:27270855

  4. The hidden cost of low prices: limited access to new drugs in India.

    PubMed

    Berndt, Ernst R; Cockburn, Iain M

    2014-09-01

    The pricing and accessibility of patent-protected drugs in low- and middle-income countries is a contentious issue in the global context. But questions about price have little meaning if a drug is not available for purchase, and the extent to which patent policy affects when (and if) new drugs become available in these countries has largely been overlooked. We examined data on the sales of 184 drugs approved by the US Food and Drug Administration between 2000 and 2009. We found that 50 percent of those 184 drugs went on sale in India only after lags of more than five years from their first worldwide introduction. More than half of the drugs that became newly available in India during the study period were produced and sold by multiple manufacturers in the country within one year of their introduction. The presence of multiple manufacturers indicates sharp competition and weak patent protection--factors that are disincentives to manufacturers to incur the costs of gaining access to the market. We conclude that modest patent and regulatory reform could bring the faster availability of a wider range of new drugs in India with limited impact on prices--a trade-off that merits greater policy attention.

  5. Costs of mating competition limit male lifetime breeding success in polygynous mammals.

    PubMed

    Lukas, Dieter; Clutton-Brock, Tim

    2014-07-01

    Although differences in breeding lifespan are an important source of variation in male fitness, the factors affecting the breeding tenure of males have seldom been explored. Here, we use cross-species comparisons to investigate the correlates of breeding lifespan in male mammals. Our results show that male breeding lifespan depends on the extent of polygyny, which reflects the relative intensity of competition for access to females. Males have relatively short breeding tenure in species where individuals have the potential to monopolize mating with multiple females, and longer ones where individuals defend one female at a time. Male breeding tenure is also shorter in species in which females breed frequently than in those where females breed less frequently, suggesting that the costs of guarding females may contribute to limiting tenure length. As a consequence of these relationships, estimates of skew in male breeding success within seasons overestimate skew calculated across the lifetime and, in several polygynous species, variance in lifetime breeding success is not substantially higher in males than in females.

  6. The hidden cost of low prices: limited access to new drugs in India.

    PubMed

    Berndt, Ernst R; Cockburn, Iain M

    2014-09-01

    The pricing and accessibility of patent-protected drugs in low- and middle-income countries is a contentious issue in the global context. But questions about price have little meaning if a drug is not available for purchase, and the extent to which patent policy affects when (and if) new drugs become available in these countries has largely been overlooked. We examined data on the sales of 184 drugs approved by the US Food and Drug Administration between 2000 and 2009. We found that 50 percent of those 184 drugs went on sale in India only after lags of more than five years from their first worldwide introduction. More than half of the drugs that became newly available in India during the study period were produced and sold by multiple manufacturers in the country within one year of their introduction. The presence of multiple manufacturers indicates sharp competition and weak patent protection--factors that are disincentives to manufacturers to incur the costs of gaining access to the market. We conclude that modest patent and regulatory reform could bring the faster availability of a wider range of new drugs in India with limited impact on prices--a trade-off that merits greater policy attention. PMID:25201661

  7. Adaptive capacity of the Adjusted Clinical Groups Case-Mix System to the cost of primary healthcare in Catalonia (Spain): a observational study

    PubMed Central

    Velasco-Velasco, Soledad; Navarro-Artieda, Ruth; Prados-Torres, Alexandra; Bolibar-Ribas, Buenaventura; Violan-Fors, Concepción

    2012-01-01

    Objectives To describe the adaptive capacity of the Adjusted Clinical Groups (ACG) system to the cost of care in primary healthcare centres in Catalonia (Spain). Design Retrospective study (multicentres) conducted using computerised medical records. Setting 13 primary care teams in 2008 were included. Participants All patients registered in the study centres who required care between 1 January and 31 December 2008 were finally studied. Patients not registered in the study centres during the study period were excluded. Outcome measures Demographic (age and sex), dependent (cost of care) and case-mix variables were studied. The cost model for each patient was established by differentiating the fixed and variable costs. To evaluate the adaptive capacity of the ACG system, Pearson's coefficient of variation and the percentage of outliers were calculated. To evaluate the explanatory power of the ACG system, the authors used the coefficient of determination (R2). Results The number of patients studied was 227 235 (frequency: 5.9 visits per person per year), with a mean of 4.5 (3.2) episodes and 8.1 (8.2) visits per patient per year. The mean total cost was €654.2. The explanatory power of the ACG system was 36.9% for costs (56.5% without outliers). 10 ACG categories accounted for 60.1% of all cases and 19 for 80.9%. 5 categories represented 71% of poor performance (N=78 887, 34.7%), particularly category 0300-Acute Minor, Age 6+ (N=26 909, 11.8%), which had a coefficient of variation =139% and 6.6% of outliers. Conclusions The ACG system is an appropriate manner of classifying patients in routine clinical practice in primary healthcare centres in Catalonia, although improvements to the adaptive capacity through disaggregation of some categories according to age groups and, especially, the number of acute episodes in paediatric patients would be necessary to reduce intra-group variation. PMID:22734115

  8. Optimal number of minimal repairs with cumulative repair cost limit for a two-unit system with failure rate interactions

    NASA Astrophysics Data System (ADS)

    Lai, Min-Tsai; Yan, Huey

    2016-01-01

    A discrete replacement model is presented that includes a cumulative repair cost limit for a two-unit system with failure rate interactions between the units. We assume a failure in unit 1 causes the failure rate in unit 2 to increase, whereas a failure in unit 2 causes a failure in unit 1, resulting in a total system failure. If unit 1 fails and the cumulative repair cost till to this failure is less than a limit L, then unit 1 is repaired. If there is a failure in unit 1 and the cumulative repair cost exceeds L or the number of failures equals n, the entire system is preventively replaced. The system is also replaced at a total failure, and such replacement cost is higher than the preventive replacement cost. The long-term expected cost per unit time is derived using the expected costs as the optimality criterion. The minimum-cost policy is derived, and existence and uniqueness are proved.

  9. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... administrative cost limit on Welfare-to-Work grants? 645.235 Section 645.235 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE-TO-WORK GRANTS General Program... cost limit on Welfare-to-Work grants? (a) Administrative cost limitation (section...

  10. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... administrative cost limit on Welfare-to-Work grants? 645.235 Section 645.235 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE-TO-WORK GRANTS General Program... cost limit on Welfare-to-Work grants? (a) Administrative cost limitation (section...

  11. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... administrative cost limit on Welfare-to-Work grants? 645.235 Section 645.235 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE-TO-WORK GRANTS General Program... cost limit on Welfare-to-Work grants? (a) Administrative cost limitation (section...

  12. Limiter

    DOEpatents

    Cohen, S.A.; Hosea, J.C.; Timberlake, J.R.

    1984-10-19

    A limiter with a specially contoured front face is provided. The front face of the limiter (the plasma-side face) is flat with a central indentation. In addition, the limiter shape is cylindrically symmetric so that the limiter can be rotated for greater heat distribution. This limiter shape accommodates the various power scrape-off distances lambda p, which depend on the parallel velocity, V/sub parallel/, of the impacting particles.

  13. Low-cost tissue simulating phantoms with adjustable wavelength-dependent scattering properties in the visible and infrared ranges

    NASA Astrophysics Data System (ADS)

    Saager, Rolf B.; Quach, Alan; Rowland, Rebecca A.; Baldado, Melissa L.; Durkin, Anthony J.

    2016-06-01

    We present a method for low-cost fabrication of polydimethylsiloxane (PDMS) tissue simulating phantoms with tunable scattering spectra, spanning visible, and near-infrared regimes. These phantoms use optical polishing agents (aluminum oxide powders) at various grit sizes to approximate in vivo tissue scattering particles across multiple size distributions (range: 17 to 3 μm). This class of tunable scattering phantoms is used to mimic distinct changes in wavelength-dependent scattering properties observed in tissue pathologies such as partial thickness burns. Described by a power-law dependence on wavelength, the scattering magnitude of these phantoms scale linearly with particle concentration over a physiologic range [μs‧=(0.5 to 2.0 mm-1)] whereas the scattering spectra, specific to each particle size distribution, correlate to distinct exponential coefficients (range: 0.007 to 0.32). Aluminum oxide powders used in this investigation did not detectably contribute to the absorption properties of these phantoms. The optical properties of these phantoms are verified through inverse adding-doubling methods and the tolerances of this fabrication method are discussed.

  14. 45 CFR 2540.110 - Limitation on use of Corporation funds for administrative costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... administrative costs. (a)(1) Not more than five percent of the grant funds provided under 45 CFR 2516, 2517, 2519... meeting operational matching requirements under the Corporation's award; (ii) Specify that a fixed rate of five percent or less (not subject to supporting cost documentation) of total Corporation funds...

  15. Limiter

    DOEpatents

    Cohen, Samuel A.; Hosea, Joel C.; Timberlake, John R.

    1986-01-01

    A limiter with a specially contoured front face accommodates the various power scrape-off distances .lambda..sub.p, which depend on the parallel velocity, V.sub..parallel., of the impacting particles. The front face of the limiter (the plasma-side face) is flat with a central indentation. In addition, the limiter shape is cylindrically symmetric so that the limiter can be rotated for greater heat distribution.

  16. Measuring demand for flat water recreation using a two-stage/disequilibrium travel cost model with adjustment for overdispersion and self-selection

    NASA Astrophysics Data System (ADS)

    McKean, John R.; Johnson, Donn; Taylor, R. Garth

    2003-04-01

    An alternate travel cost model is applied to an on-site sample to estimate the value of flat water recreation on the impounded lower Snake River. Four contiguous reservoirs would be eliminated if the dams are breached to protect endangered Pacific salmon and steelhead trout. The empirical method applies truncated negative binomial regression with adjustment for endogenous stratification. The two-stage decision model assumes that recreationists allocate their time among work and leisure prior to deciding among consumer goods. The allocation of time and money among goods in the second stage is conditional on the predetermined work time and income. The second stage is a disequilibrium labor market which also applies if employers set work hours or if recreationists are not in the labor force. When work time is either predetermined, fixed by contract, or nonexistent, recreationists must consider separate prices and budgets for time and money.

  17. Small Schools in Small School Districts and Small Schools in Large School Districts: Are There Cost Differences That Should Be Captured in the Small School Adjustment of the Wyoming School Funding Formula? Final Report.

    ERIC Educational Resources Information Center

    Picus, Lawrence O.; Seder, Richard

    2004-01-01

    The purpose of this study was to determine if the cost structure of small schools located in large Wyoming school districts differed from the cost structure of small schools located in small districts across the state, and if a difference was found to recommend possible changes to the small school adjustment in the Wyoming school funding model.…

  18. 20 CFR 641.876 - When will compliance with cost limitations and minimum expenditure levels be determined?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and minimum expenditure levels be determined? 641.876 Section 641.876 Employees' Benefits EMPLOYMENT... EMPLOYMENT PROGRAM Administrative Requirements § 641.876 When will compliance with cost limitations and minimum expenditure levels be determined? The Department will determine compliance by...

  19. 20 CFR 669.555 - Do the WIA administrative cost limits for States and local areas apply to NFJP grants?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TRAINING ADMINISTRATION, DEPARTMENT OF LABOR NATIONAL FARMWORKER JOBS PROGRAM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Performance Accountability, Planning and Waiver Provision § 669.555 Do the WIA administrative cost limits for States and local areas apply to NFJP grants? No, under 20 CFR 667.210(b),...

  20. 20 CFR 669.555 - Do the WIA administrative cost limits for States and local areas apply to NFJP grants?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TRAINING ADMINISTRATION, DEPARTMENT OF LABOR NATIONAL FARMWORKER JOBS PROGRAM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Performance Accountability, Planning and Waiver Provision § 669.555 Do the WIA administrative cost limits for States and local areas apply to NFJP grants? No, under 20 CFR 667.210(b),...

  1. Cost estimation when time and resources are limited: the Brief DATCAP.

    PubMed

    French, Michael T; Roebuck, M Christopher; McLellan, A Thomas

    2004-10-01

    The Drug Abuse Treatment Cost Analysis Program (DATCAP) was designed in the early 1990s as a research guide to collect and analyze financial data from addiction treatment programs. The addiction research community could clearly benefit from a version of the DATCAP that reduced the time and effort required for its administration without compromising the integrity of its cost estimates. This paper introduces the Brief DATCAP and presents some preliminary findings. Initial feedback from respondents suggests that the Brief DATCAP is understandable, and easier and quicker to complete than the DATCAP. More importantly, preliminary results indicate that cost estimates from the Brief DATCAP differ from those of the longer DATCAP by less than 2%. These results have important research and policy implications because a shorter yet reasonably accurate cost instrument will enhance the feasibility and precision of future economic evaluations of addiction interventions.

  2. Simple and cost-effective fabrication of solid biodegradable polymer microneedle arrays with adjustable aspect ratio for transdermal drug delivery using acupuncture microneedles

    NASA Astrophysics Data System (ADS)

    Cha, Kyoung Je; Kim, Taewan; Jea Park, Sung; Kim, Dong Sung

    2014-11-01

    Polymer microneedle arrays (MNAs) have received much attention for their use in transdermal drug delivery and microneedle therapy systems due to the advantages they offer, such as low cost, good mechanical properties, and a versatile choice of materials. Here, we present a simple and cost-effective method for the fabrication of a biodegradable polymer MNA in which the aspect ratio of each microneedle is adjustable using commercially available acupuncture microneedles. In our process, a master template with acupuncture microneedles, whose shape will be the final MNA, was carefully prepared by fixing them onto a plastic substrate with selectively drilled holes which, in turn, determine the aspect ratios of the microneedles. A polylactic acid (PLA; a biodegradable polymer) MNA was fabricated by a micromolding process with a polydimethylsiloxane (PDMS) mold containing the cavity of the microneedles, which was obtained by the PDMS replica molding against the master template. The mechanical force and degradation behavior of the replicated PLA MNA were characterized with the help of a compression test and an accelerated degradation test, respectively. Finally, the transdermal drug delivery performance of the PLA MNA was successfully simulated by two different methods of penetration and staining, using the skin of a pig cadaver. These results indicated that the proposed method can be effectively used for the fabrication of polymer MNAs which can be used in various microneedle applications.

  3. Lower net pressure reverse osmosis membranes and systems - cost and performance advantages and limitations. Final report

    SciTech Connect

    Kremen, S.S.; Hull, C.E.; Jhawar, M.

    1982-06-01

    Reverse osmosis systems are generally designed and utilized on the basis of reference membrane water flux and desalting performance at 400 psi net driving pressure (NDP). Membranes now being offered and tested at a preliminary commercial stage are capable of equivalent performance at 200 psi NDP. These membranes offer immediately obvious savings in energy costs for reverse osmosis desalting and water reclamation. In addition, they can make a most important contribution to reduced membrane replacement costs and improved permeate quality when operating on high salinity feeds at higher recovery levels. A number of hypothetical cases were developed and tabulated, assuming a 200 psi NDP sea water membrane was available. Substantial benefits could be expected if such a membrane could be developed and reduced to practice. Additional cost savings and performance improvements can be realized by operating the 200 psi NDP membranes at somewhat higher applied pressures which preserve or enhance NDP.

  4. Limiting the Number of Lumens in Peripherally Inserted Central Catheters to Improve Outcomes and Reduce Cost: A Simulation Study.

    PubMed

    Ratz, David; Hofer, Timothy; Flanders, Scott A; Saint, Sanjay; Chopra, Vineet

    2016-07-01

    BACKGROUND The number of peripherally inserted central catheter (PICC) lumens is associated with thrombotic and infectious complications. Because multilumen PICCs are not necessary in all patients, policies that limit their use may improve safety and cost. OBJECTIVE To design a simulation-based analysis to estimate outcomes and cost associated with a policy that encourages single-lumen PICC use. METHODS Model inputs, including risk of complications and costs associated with single- and multilumen PICCs, were obtained from available literature and a multihospital collaborative quality improvement project. Cost savings and reduction in central line-associated bloodstream infection and deep vein thrombosis events from institution of a single-lumen PICC default policy were reported. RESULTS According to our model, a hospital that places 1,000 PICCs per year (25% of which are single-lumen and 75% multilumen) experiences annual PICC-related maintenance and complication costs of $1,228,598 (95% CI, $1,053,175-$1,430,958). In such facilities, every 5% increase in single-lumen PICC use would prevent 0.5 PICC-related central line-associated bloodstream infections and 0.5 PICC-related deep vein thrombosis events, while saving $23,500. Moving from 25% to 50% single-lumen PICC utilization would result in total savings of $119,283 (95% CI, $74,030-$184,170) per year. Regardless of baseline prevalence, a single-lumen default PICC policy would be associated with approximately 10% cost savings. Findings remained robust in multiway sensitivity analyses. CONCLUSION Hospital policies that limit the number of PICC lumens may enhance patient safety and reduce healthcare costs. Studies measuring intended and unintended consequences of this approach, followed by rapid adoption, appear necessary. Infect Control Hosp Epidemiol 2016;37:811-817.

  5. The Benefits, Limitations, and Cost-Effectiveness of Advanced Technologies in the Management of Patients With Diabetes Mellitus

    PubMed Central

    Vigersky, Robert A.

    2015-01-01

    Background: Hypoglycemia mitigation is critical for appropriately managing patients with diabetes. Advanced technologies are becoming more prevalent in diabetes management, but their benefits have been primarily judged on the basis of hemoglobin A1c. A critical appraisal of the effectiveness and limitations of advanced technologies in reducing both A1c and hypoglycemia rates has not been previously performed. Methods: The cost of hypoglycemia was estimated using literature rates of hypoglycemia events resulting in hospitalizations. A literature search was conducted on the effect on A1c and hypoglycemia of advanced technologies. The cost-effectiveness of continuous subcutaneous insulin infusion (CSII) and real-time continuous glucose monitors (RT-CGM) was reviewed. Results: Severe hypoglycemia in insulin-using patients with diabetes costs $4.9-$12.7 billion. CSII reduces A1c in some but not all studies. CSII improves hypoglycemia in patients with high baseline rates. Bolus calculators improve A1c and improve the fear of hypoglycemia but not hypoglycemia rates. RT-CGM alone and when combined with CSII improve A1c with a neutral effect on hypoglycemia rates. Low-glucose threshold suspend systems reduce hypoglycemia with a neutral effect on A1c, and low-glucose predictive suspend systems reduce hypoglycemia with a small increase in plasma glucose levels. In short-term studies, artificial pancreas systems reduce both hypoglycemia rates and plasma glucose levels. CSII and RT-CGM are cost-effective technologies, but their wide adoption is limited by cost, psychosocial, and educational factors. Conclusions: Most currently available technologies improve A1c with a neutral or improved rate of hypoglycemia. Advanced technologies appear to be cost-effective in diabetes management, especially when including the underlying cost of hypoglycemia. PMID:25555391

  6. Limited encoding of effort by dopamine neurons in a cost-benefit trade-off task

    PubMed Central

    Pasquereau, Benjamin; Turner, Robert S.

    2013-01-01

    Animals are thought to evaluate the desirability of action options using a unified scale that combines predicted benefits (“rewards”), costs, and the animal’s internal motivational state. Midbrain dopamine neurons have long been associated with the reward part of this equation, but it is unclear whether these neurons also estimate the costs of taking an action. We studied the spiking activity of dopamine neurons in the substantia nigra pars compacta of monkeys (Macaca mulatta) during a reaching task in which the energetic costs incurred (friction loads) and the benefits gained (drops of food) were manipulated independently. Although the majority of dopamine neurons encoded the upcoming reward alone, a subset predicted net utility of a course of action by signaling the expected reward magnitude, discounted by the invested cost in terms of physical effort. In addition, the tonic activity of some dopamine neurons was slowly reduced in conjunction with the accumulated trials, which is consistent with the hypothesized role for tonic dopamine in the invigoration or motivation of instrumental responding. The present results shed light on an oft-hypothesized role for dopamine in the regulation of the balance in natural behaviors between the energy expended and the benefits gained, which could explain why dopamine disorders, such as Parkinson’s disease, lead to a breakdown of that balance. PMID:23658169

  7. Local Property Tax Limitations vs. School District Employee Pension Costs in Pennsylvania

    ERIC Educational Resources Information Center

    Hartman, William T.; Shrom, Timothy J.

    2014-01-01

    In Pennsylvania as in many other states, employee pension costs are a significant source of financial pressure for school districts (Zeehandelaar and Northern 2013, Pennsylvania Public Employees' Retirement Commission 2013). In order to gain greater insight into the nature of Pennsylvania school districts' financial burden related to…

  8. 48 CFR 2152.216-70 - Fixed price with limited cost redetermination-risk charge.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... cost redetermination-risk charge. 2152.216-70 Section 2152.216-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  9. 48 CFR 2152.216-70 - Fixed price with limited cost redetermination-risk charge.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... cost redetermination-risk charge. 2152.216-70 Section 2152.216-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  10. 48 CFR 2152.216-70 - Fixed price with limited cost redetermination-risk charge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... cost redetermination-risk charge. 2152.216-70 Section 2152.216-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  11. 48 CFR 2152.216-71 - Fixed price with limited cost redetermination-service charge.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... cost redetermination-service charge. 2152.216-71 Section 2152.216-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  12. 48 CFR 2152.216-71 - Fixed price with limited cost redetermination-service charge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... cost redetermination-service charge. 2152.216-71 Section 2152.216-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  13. 48 CFR 2152.216-70 - Fixed price with limited cost redetermination-risk charge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... cost redetermination-risk charge. 2152.216-70 Section 2152.216-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  14. 48 CFR 2152.216-71 - Fixed price with limited cost redetermination-service charge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... cost redetermination-service charge. 2152.216-71 Section 2152.216-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  15. 48 CFR 2152.216-71 - Fixed price with limited cost redetermination-service charge.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... cost redetermination-service charge. 2152.216-71 Section 2152.216-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION... request, OPM will furnish, during the third quarter of the current contract year, an accounting of...

  16. 38 CFR 3.27 - Automatic adjustment of benefit rates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... adjustment of benefit rates. (a) Improved pension. Whenever there is a cost-of-living increase in benefit... income limitation and maximum monthly rates. Whenever there is a cost-of-living increase in benefit...(b)(1)) (c) Monetary allowance under 38 U.S.C. chapter 18 for certain individuals who are children...

  17. 38 CFR 3.27 - Automatic adjustment of benefit rates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... adjustment of benefit rates. (a) Improved pension. Whenever there is a cost-of-living increase in benefit... income limitation and maximum monthly rates. Whenever there is a cost-of-living increase in benefit...(b)(1)) (c) Monetary allowance under 38 U.S.C. chapter 18 for certain individuals who are children...

  18. 38 CFR 3.27 - Automatic adjustment of benefit rates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... adjustment of benefit rates. (a) Improved pension. Whenever there is a cost-of-living increase in benefit... income limitation and maximum monthly rates. Whenever there is a cost-of-living increase in benefit...(b)(1)) (c) Monetary allowance under 38 U.S.C. chapter 18 for certain individuals who are children...

  19. 38 CFR 3.27 - Automatic adjustment of benefit rates.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... adjustment of benefit rates. (a) Improved pension. Whenever there is a cost-of-living increase in benefit... income limitation and maximum monthly rates. Whenever there is a cost-of-living increase in benefit...(b)(1)) (c) Monetary allowance under 38 U.S.C. chapter 18 for certain individuals who are children...

  20. Strategies for Providing Low-Cost Water Immersion Therapy With Limited Resources.

    PubMed

    Brickhouse, Brenda; Isaacs, Christine; Batten, Meghann; Price, Amber

    At our university-affiliated medical center, a major renovation of the women's health and birthing unit resulted in the temporary loss of the permanent tub used for water immersion therapy during labor. Because 40 percent of the women in the nurse-midwifery practice utilize hydrotherapy, we undertook a rigorous search for an interim solution. We developed a safe and cost-effective strategy that can be easily replicated and utilized by others to provide hydrotherapy for laboring women. PMID:26682659

  1. [Structural adjustment, cultural adjustment?].

    PubMed

    Dujardin, B; Dujardin, M; Hermans, I

    2003-12-01

    Over the last two decades, multiple studies have been conducted and many articles published about Structural Adjustment Programmes (SAPs). These studies mainly describe the characteristics of SAPs and analyse their economic consequences as well as their effects upon a variety of sectors: health, education, agriculture and environment. However, very few focus on the sociological and cultural effects of SAPs. Following a summary of SAP's content and characteristics, the paper briefly discusses the historical course of SAPs and the different critiques which have been made. The cultural consequences of SAPs are introduced and are described on four different levels: political, community, familial, and individual. These levels are analysed through examples from the literature and individual testimonies from people in the Southern Hemisphere. The paper concludes that SAPs, alongside economic globalisation processes, are responsible for an acute breakdown of social and cultural structures in societies in the South. It should be a priority, not only to better understand the situation and its determining factors, but also to intervene and act with strategies that support and reinvest in the social and cultural sectors, which is vital in order to allow for individuals and communities in the South to strengthen their autonomy and identify.

  2. Limiting the costs of mutalism: multiple modes of interaction between yuccas and yucca moths

    PubMed Central

    Addicott, J. F.; Bao, T.

    1999-01-01

    In pollination–seed predation mutualisms between yuccas and yucca moths, conflicts of interest exist for yuccas, because benefits of increased pollination may be outweighed by increased seed consumption. These conflicts raise the problem of what limits seed consumption, and ultimately what limits or regulates moth populations. Although the current hypothesis is that yuccas should selectively abscise flowers with high numbers of yucca-moth eggs, within-inflorescence selective abscission occurs in only one of the three moth–yucca systems that we studied. It occurs only when oviposition directly damages developing ovules, and does not, therefore, provide a general explanation for the resolution of moth–yucca conflicts. Within-locule egg mortality provides an alternative and stronger mechanism for limiting seed damage, and generating density-dependent mortality for yucca-moth populations. However, the most important feature of moth–yucca systems is that they are diverse, encompassing multiple modes of interaction, each with different consequences for limiting and regulating yucca moths.

  3. Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy.

    PubMed

    Das, Suman R; Hensley, Scott E; David, Alexandre; Schmidt, Loren; Gibbs, James S; Puigbò, Pere; Ince, William L; Bennink, Jack R; Yewdell, Jonathan W

    2011-12-20

    Here, we address the question of why the influenza A virus hemagglutinin (HA) does not escape immunity by hyperglycosylation. Uniquely among dozens of monoclonal antibodies specific for A/Puerto Rico/8/34, escape from H28-A2 neutralization requires substitutions introducing N-linked glycosylation at residue 131 or 144 in the globular domain. This escape decreases viral binding to cellular receptors, which must be compensated for by additional substitutions in HA or neuraminidase that enable viral replication. Sequence analysis of circulating H1 influenza viruses confirms the in vivo relevance of our findings: natural occurrence of glycosylation at residue 131 is always accompanied by a compensatory mutation known to increase HA receptor avidity. In vaccinated mice challenged with WT vs. H28-A2 escape mutants, the selective advantage conferred by glycan-mediated global reduction in antigenicity is trumped by the costs of diminished receptor avidity. These findings show that, although N-linked glycosylation can broadly diminish HA antigenicity, fitness costs restrict its deployment in immune evasion.

  4. Costs of a limited patient notification exercise following infection control failures in a dental surgery.

    PubMed

    Conrad, D; Dardamissis, E; Oyinloye, A; Vivancos, R; Ratcliffe, P

    2011-08-01

    In February 2008, a primary care trust in Cheshire Merseyside was notified of failures in the infection control practises of a dentist working in a large group practice. On advice from national experts, a look-back was undertaken to identify any patients infected with hepatitis followed by a notification exercise of patients who had received invasive treatment immediately afterwards. One patient with hepatitis C (HCV) was identified. Sixty patients were notified by letter and offered advice and HCV screening. The total cost of the patient notification exercise (PNE) was estimated at £85,936, equating to £1,562.47 per patient who responded to the notification (55), or £2,455.31 per patient screened (35). All results were negative. While this adds to evidence that the risk to patients in such incidents is small, failing to investigate the possibility that BBV transmission has occurred would carry public health, reputational and legal risks. Conducting a PNE in the first instance for those patients at highest risk, with the option of extending it if evidence of patient-to-patient transmission is found, ensures that the total costs of dealing appropriately with such incidents - while still substantial - are at least kept to a minimum. PMID:21869792

  5. Effects of cryptic mortality and the hidden costs of using length limits in fishery management

    USGS Publications Warehouse

    Coggins, L.G.; Catalano, M.J.; Allen, M.S.; Pine, William E.; Walters, C.J.

    2007-01-01

    Fishery collapses cause substantial economic and ecological harm, but common management actions often fail to prevent overfishing. Minimum length limits are perhaps the most common fishing regulation used in both commercial and recreational fisheries, but their conservation benefits can be influenced by discard mortality of fish caught and released below the legal length. We constructed a computer model to evaluate how discard mortality could influence the conservation utility of minimum length regulations. We evaluated policy performance across two disparate fish life-history types: short-lived high-productivity (SLHP) and long-lived low-productivity (LLLP) species. For the life-history types, fishing mortality rates and minimum length limits that we examined, length limits alone generally failed to achieve sustainability when discard mortality rate exceeded about 0.2 for SLHP species and 0.05 for LLLP species. At these levels of discard mortality, reductions in overall fishing mortality (e.g. lower fishing effort) were required to prevent recruitment overfishing if fishing mortality was high. Similarly, relatively low discard mortality rates (>0.05) rendered maximum yield unobtainable and caused a substantial shift in the shape of the yield response surfaces. An analysis of fishery efficiency showed that length limits caused the simulated fisheries to be much less efficient, potentially exposing the target species and ecosystem to increased negative effects of the fishing process. Our findings suggest that for overexploited fisheries with moderate-to-high discard mortality rates, reductions in fishing mortality will be required to meet management goals. Resource managers should carefully consider impacts of cryptic mortality sources (e.g. discard mortality) on fishery sustainability, especially in recreational fisheries where release rates are high and effort is increasing in many areas of the world. ?? 2007 Blackwell Publishing Ltd.

  6. Limiting the public cost of stationary battery deployment by combining applications

    NASA Astrophysics Data System (ADS)

    Stephan, A.; Battke, B.; Beuse, M. D.; Clausdeinken, J. H.; Schmidt, T. S.

    2016-07-01

    Batteries could be central to low-carbon energy systems with high shares of intermittent renewable energy sources. However, the investment attractiveness of batteries is still perceived as low, eliciting calls for policy to support deployment. Here we show how the cost of battery deployment can potentially be minimized by introducing an aspect that has been largely overlooked in policy debates and underlying analyses: the fact that a single battery can serve multiple applications. Batteries thereby can not only tap into different value streams, but also combine different risk exposures. To address this gap, we develop a techno-economic model and apply it to the case of lithium-ion batteries serving multiple stationary applications in Germany. Our results show that batteries could be attractive for investors even now if non-market barriers impeding the combination of applications were removed. The current policy debate should therefore be refocused so as to encompass the removal of such barriers.

  7. Limiting the public cost of stationary battery deployment by combining applications

    NASA Astrophysics Data System (ADS)

    Stephan, A.; Battke, B.; Beuse, M. D.; Clausdeinken, J. H.; Schmidt, T. S.

    2016-07-01

    Batteries could be central to low-carbon energy systems with high shares of intermittent renewable energy sources. However, the investment attractiveness of batteries is still perceived as low, eliciting calls for policy to support deployment. Here we show how the cost of battery deployment can potentially be minimized by introducing an aspect that has been largely overlooked in policy debates and underlying analyses: the fact that a single battery can serve multiple applications. Batteries thereby can not only tap into different value streams, but also combine different risk exposures. To address this gap, we develop a techno-economic model and apply it to the case of lithium-ion batteries serving multiple stationary applications in Germany. Our results show that batteries could be attractive for investors even now if non-market barriers impeding the combination of applications were removed. The current policy debate should therefore be refocused so as to encompass the removal of such barriers.

  8. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... to be allocated as administrative or program costs to the benefitting cost objectives/categories... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false What types of activities are subject to the administrative cost limit on Welfare-to-Work grants? 645.235 Section 645.235 Employees' Benefits EMPLOYMENT...

  9. Factors limiting the sensitivity and dynamic range of a seismic system employing analog magnetic tape recording and a seismic amplifier with adjustable gain settings and several output levels

    USGS Publications Warehouse

    Eaton, Jerry P.; Van Schaack, John R.

    1977-01-01

    In the course of modernizing the low-speed-tape-recorder portable seismic systems and considering the possibilities for the design of a cassette-tape-recorder seismic refraction system, the factors that limit the sensitivity and dynamic range of such systems have been reviewed. These factors will first be stated briefly, and then their influence on systems such as the new 5-day-tape seismic system will be examined in more detail. To fix ideas, we shall assume that the system consists of the following elements: 1. A seismic sensor: usually a moving coil inertial seismometer with a period of about 1 second, a coil resistance of about 5000 ohms, and an effective motor constant of 1.0 V/cm/sec (across a 10K load terminating the seismometer sensitivity-and-damping-adjustment resistive network). 2. A seismic amplifier/voltage controlled oscillator unit made up of the following components: a) A fixed gain preamplifier with an input resistance of 10K and an internal noise level of 0.5 muVpp referred to the preamp input (0.1 Hz <= freq. <= 30 hz). b) An adjustable gain (0 to 42 db in 6 db steps) intermediate amplifier c) One or more fixed gain output amplifiers. d) Two sections of 6 db/octave bandpass filter serving to couple the 3 amplifier stages together. e) Voltage controlled oscillators for each output amplifier to produce modulated FM carriers for recording on separate tape tracks or modulated FM subcarriers for subsequent multiplexing and direct recording on tape in the California Network format. 3. An analog magnetic tape recorder: e.g. the PI 5100 (15/80 ips recording in the FM mode or in the direct mode with the 'broad-band' variant-of the Cal Net multiplex system, or 15/16 ips recording in the direct mode with the standard Cal Net multiplex system), or the Sony TC-126 cassette recorder operating in the direct record mode with the standard Cal Net multiplex system. 4. Appropriate magnetic tape playback equipment: e.g., the Bell and Howell 3700-B for the PI-5100 or

  10. Limitations of ozone data assimilation with adjustment of NOx emissions: mixed effects on NO2 forecast over Beijing and surrounding areas

    NASA Astrophysics Data System (ADS)

    Tang, X.; Zhu, J.; Wang, Z. F.; Gbaguidi, A.; Lin, C. Y.; Xin, J. Y.; Song, T.; Hu, B.

    2015-12-01

    impacts over suburban sites, were found to be strongly associated with the linearization of the EnKF at the analysis step and the fast variability of the relationship between ozone concentrations and NOx emissions. When the uncertainties of the daytime ozone concentrations were strongly nonlinearly related to those of the NOx emissions, the linearization analysis of the EnKF brought out an inefficient or a wrong adjustment to the NOx emissions during the daytime. The results of this study provided further explanations for the negative DA impacts observed in previous chemical DA studies and highlighted the limitation of the existing chemical DA methods under high nonlinearity.

  11. Limitations of ozone data assimilation with adjustment of NOx emissions: mixed effects on NO2 forecasts over Beijing and surrounding areas

    NASA Astrophysics Data System (ADS)

    Tang, Xiao; Zhu, Jiang; Wang, ZiFa; Gbaguidi, Alex; Lin, CaiYan; Xin, JinYuan; Song, Tao; Hu, Bo

    2016-05-01

    This study investigates a cross-variable ozone data assimilation (DA) method based on an ensemble Kalman filter (EnKF) that has been used in the companion study to improve ozone forecasts over Beijing and surrounding areas. The main purpose is to delve into the impacts of the cross-variable adjustment of nitrogen oxide (NOx) emissions on the nitrogen dioxide (NO2) forecasts over this region during the 2008 Beijing Olympic Games. A mixed effect on the NO2 forecasts was observed through application of the cross-variable assimilation approach in the real-data assimilation (RDA) experiments. The method improved the NO2 forecasts over almost half of the urban sites with reductions of the root mean square errors (RMSEs) by 15-36 % in contrast to big increases of the RMSEs over other urban stations by 56-239 %. Over the urban stations with negative DA impacts, improvement of the NO2 forecasts (with 7 % reduction of the RMSEs) was noticed at night and in the morning versus significant deterioration during daytime (with 190 % increase of the RMSEs), suggesting that the negative data assimilation impacts mainly occurred during daytime. Ideal-data assimilation (IDA) experiments with a box model and the same cross-variable assimilation method confirmed the mixed effects found in the RDA experiments. In the same way, NOx emission estimation was improved at night and in the morning even under large biases in the prior emission, while it deteriorated during daytime (except for the case of minor errors in the prior emission). The mixed effects observed in the cross-variable data assimilation, i.e., positive data assimilation impacts on NO2 forecasts over some urban sites, negative data assimilation impacts over the other urban sites, and weak data assimilation impacts over suburban sites, highlighted the limitations of the EnKF under strong nonlinear relationships between chemical variables. Under strong nonlinearity between daytime ozone concentrations and NOx emissions

  12. Non-parametric methods for cost-effectiveness analysis: the central limit theorem and the bootstrap compared.

    PubMed

    Nixon, Richard M; Wonderling, David; Grieve, Richard D

    2010-03-01

    Cost-effectiveness analyses (CEA) alongside randomised controlled trials commonly estimate incremental net benefits (INB), with 95% confidence intervals, and compute cost-effectiveness acceptability curves and confidence ellipses. Two alternative non-parametric methods for estimating INB are to apply the central limit theorem (CLT) or to use the non-parametric bootstrap method, although it is unclear which method is preferable. This paper describes the statistical rationale underlying each of these methods and illustrates their application with a trial-based CEA. It compares the sampling uncertainty from using either technique in a Monte Carlo simulation. The experiments are repeated varying the sample size and the skewness of costs in the population. The results showed that, even when data were highly skewed, both methods accurately estimated the true standard errors (SEs) when sample sizes were moderate to large (n>50), and also gave good estimates for small data sets with low skewness. However, when sample sizes were relatively small and the data highly skewed, using the CLT rather than the bootstrap led to slightly more accurate SEs. We conclude that while in general using either method is appropriate, the CLT is easier to implement, and provides SEs that are at least as accurate as the bootstrap.

  13. Analysis of EPA`s cost-effectiveness study for the coastal oil and gas effluent limitations guidelines

    SciTech Connect

    Veil, J.

    1995-05-01

    The US Environmental Protection Agency (EPA) conducted a cost-effectiveness (CE) analysis to estimate the incremental cost of complying with the proposed effluent limitation guidelines (ELGs) for the coastal oil and gas industry (EPA 1995a). EPA`s CE analysis calculates the pounds of each pollutant that would be removed if the chosen discharge option is selected. In 1993, EPA issued final ELGs for the offshore oil and gas industry and published an offshore CE analysis. The chemical characteristics of produced water from the offshore region are essentially the same as those of produced water from the coastal region. It was surprising, therefore, that EPA chose a much longer list of pollutants and generally stricter weighting factors for the coastal CE analysis. This report reviews the data, assumptions, and analyses used in EPA`s coastal CE analysis and identifies alternate data, assumptions, and analyses that could lead to significantly different cost-effectiveness conclusions. Two alternate lists of pollutants are proposed, along with recalculated weighting factors for several pollutants that contributed a large proportion of the total PEs removed--radium, benzo(a)pyrene, boron, and ammonia. By using different combinations of these variables, a range of revised estimates of CE is calculated.

  14. Low cost HIV-1 quantitative RT-PCR assay in resource-limited settings: improvement and implementation.

    PubMed

    Fibriani, Azzania; Farah, Nadya; Kusumadewi, Inri; Pas, Suzan D; van Crevel, Reinout; van der Ven, Andre; Boucher, Charles A B; Schutten, Martin

    2012-10-01

    Monitoring of HIV viral load in low and middle income settings is limited by high cost of the commercial assays. Therefore, we developed a novel RT-PCR quantitative assay was developed. This assay targets the HIV-1 pol integrase gene (INT). Subsequently, the performance of the INT assay, described previously as a Long Terminal Repeat (LTR) assay and a combined INT/LTR dual target RT-PCR assay was compared. The LTR-assay was found to be sensitive and cost-effective (50-70% cheaper than commercial assays) with the lowest coefficient of variation (%CV). Introduction of an internal standard further improved assay reliability. Therefore, this LTR assay was implemented in West Java, Indonesia. Linearity and precision of the LTR assay were good: %CV ranged from 1.0% to 10.4%. The limit of quantitation was 616 copies/ml. Performance was comparable with the commercial assay (Abbott assay) (r(2)=0.01), although on average the viral loads were 0.39 log(10)copies/ml lower. In clinical practice, it had excellent capability for monitoring treatment failure, the positive predictive value was 99% and the negative predictive value was 93%. In conclusion, the implementation of the improved HIV-1 viral load LTR-assay for routine diagnosis in resource poor settings can be a good alternative when commercial assays are unaffordable.

  15. Intra- and Trans-Generational Costs of Reduced Female Body Size Caused by Food Limitation Early in Life in Mites

    PubMed Central

    Walzer, Andreas; Schausberger, Peter

    2013-01-01

    Background Food limitation early in life may be compensated for by developmental plasticity resulting in accelerated development enhancing survival at the expense of small adult body size. However and especially for females in non-matching maternal and offspring environments, being smaller than the standard may incur considerable intra- and trans-generational costs. Methodology/Principal Findings Here, we evaluated the costs of small female body size induced by food limitation early in life in the sexually size-dimorphic predatory mite Phytoseiulus persimilis. Females are larger than males. These predators are adapted to exploit ephemeral spider mite prey patches. The intra- and trans-generational effects of small maternal body size manifested in lower maternal survival probabilities, decreased attractiveness for males, and a reduced number and size of eggs compared to standard-sized females. The trans-generational effects of small maternal body size were sex-specific with small mothers producing small daughters but standard-sized sons. Conclusions/Significance Small female body size apparently intensified the well-known costs of sexual activity because mortality of small but not standard-sized females mainly occurred shortly after mating. The disadvantages of small females in mating and egg production may be generally explained by size-associated morphological and physiological constraints. Additionally, size-assortative mate preferences of standard-sized mates may have rendered small females disproportionally unattractive mating partners. We argue that the sex-specific trans-generational effects were due to sexual size dimorphism – females are the larger sex and thus more strongly affected by maternal stress than the smaller males – and to sexually selected lower plasticity of male body size. PMID:24265745

  16. Secondary Measures of Access to Abortion Services in the United States, 2011 and 2012: Gestational Age Limits, Cost, and Harassment

    PubMed Central

    Jerman, Jenna; Jones, Rachel K.

    2016-01-01

    Background Aspects of U.S. clinical abortion service provision such as gestational age limits, charges for abortion services, and anti-abortion harassment can impact the accessibility of abortion; this study documents changes in these measures between 2008 and 2012. Methods In 2012 and 2013, we surveyed all known abortion-providing facilities in the United States (n = 1,720). This study summarizes information obtained about gestational age limits, charges, and exposure to anti-abortion harassment among clinics; response rates for relevant items ranged from 54% (gestational limits) to 80% (exposure to harassment). Weights were constructed to compensate for nonresponding facilities. We also examine the distribution of abortions and abortion facilities by region. Findings Almost all abortion facilities (95%) offered abortions at 8 weeks’ gestation; 72% did so at 12 weeks, 34% at 20 weeks, and 16% at 24 weeks in 2012. In 2011 and 2012, the median charge for a surgical abortion at 10 weeks gestation was $495, and $500 for an early medication abortion, compared with $503 and $524 (adjusted for inflation) in 2009. In 2011, 84% of clinics experienced at least one form of harassment, only slightly higher than found in 2009. Hospitals and physicians’ offices accounted for a substantially smaller proportion of facilities in the Midwest and South. Clinics in the Midwest and South were exposed to more harassment than their counterparts in the Northeast and West. Conclusions Although there was a substantial decline in abortion incidence between 2008 and 2011, the secondary measures of abortion access examined in this study changed little during this time period. PMID:24981401

  17. Cost tradeoffs in consequence management at nuclear power plants: A risk based approach to setting optimal long-term interdiction limits for regulatory analyses

    SciTech Connect

    Mubayi, V.

    1995-05-01

    The consequences of severe accidents at nuclear power plants can be limited by various protective actions, including emergency responses and long-term measures, to reduce exposures of affected populations. Each of these protective actions involve costs to society. The costs of the long-term protective actions depend on the criterion adopted for the allowable level of long-term exposure. This criterion, called the ``long term interdiction limit,`` is expressed in terms of the projected dose to an individual over a certain time period from the long-term exposure pathways. The two measures of offsite consequences, latent cancers and costs, are inversely related and the choice of an interdiction limit is, in effect, a trade-off between these two measures. By monetizing the health effects (through ascribing a monetary value to life lost), the costs of the two consequence measures vary with the interdiction limit, the health effect costs increasing as the limit is relaxed and the protective action costs decreasing. The minimum of the total cost curve can be used to calculate an optimal long term interdiction limit. The calculation of such an optimal limit is presented for each of five US nuclear power plants which were analyzed for severe accident risk in the NUREG-1150 program by the Nuclear Regulatory Commission.

  18. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... costs are those costs related to the overall management of the program. These costs can be in both the personnel and non-personnel categories. (2) Grantees must charge the costs of organization-wide management functions as development and administrative costs. These functions include planning, coordination...

  19. Isoprene emissions from downy oak under water limitation during an entire growing season: what cost for growth?

    PubMed

    Genard-Zielinski, Anne-Cyrielle; Ormeño, Elena; Boissard, Christophe; Fernandez, Catherine

    2014-01-01

    Increases in the production of terpene- and phenolic-like compounds in plant species under abiotic stress conditions have been interpreted in physiological studies as a supplementary defense system due to their capacity to limit cell oxidation. From an ecological perspective however, these increases are only expected to confer competitive advantages if they do not imply a significant cost for the plant, that is, growth reduction. We investigated shifts of isoprene emissions, and to a lesser extent phenolic compound concentration, of Quercus pubescens Willd. from early leaf development to leaf senescence under optimal watering (control: C), mild and severe water stress (MS, SS). The impact of water stress was concomitantly assessed on plant physiological (chlorophyll fluorescence, stomatal conductance, net photosynthesis, water potential) functional (relative leaf water content, leaf mass per area ratio) and growth (aerial and root biomass) traits. Growth changes allowed to estimate the eventual costs related to the production of isoprene and phenolics. The total phenolic content was not modified under water stress whereas isoprene emissions were promoted under MS over the entire growing cycle despite the decline of Pn by 35%. Under SS, isoprene emissions remained similar to C all over the study despite the decline of Pn by 47% and were thereby clearly uncoupled to Pn leading to an overestimation of the isoprene emission factor by 44%. Under SS, maintenance of isoprene emissions and phenolic compound concentration resulted in very significant costs for the plants as growth rates were very significantly reduced. Under MS, increases of isoprene emission and maintenance of phenolic compound concentration resulted in moderate growth reduction. Hence, it is likely that investment in isoprene emissions confers Q. pubescens an important competitive advantage during moderate but not severe periods of water scarcity. Consequences of this response for air quality in North

  20. Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings

    PubMed Central

    Lam, Christopher T.; Krieger, Marlee S.; Gallagher, Jennifer E.; Asma, Betsy; Muasher, Lisa C.; Schmitt, John W.; Ramanujam, Nimmi

    2015-01-01

    Introduction Current guidelines by WHO for cervical cancer screening in low- and middle-income countries involves visual inspection with acetic acid (VIA) of the cervix, followed by treatment during the same visit or a subsequent visit with cryotherapy if a suspicious lesion is found. Implementation of these guidelines is hampered by a lack of: trained health workers, reliable technology, and access to screening facilities. A low cost ultra-portable Point of Care Tampon based digital colposcope (POCkeT Colposcope) for use at the community level setting, which has the unique form factor of a tampon, can be inserted into the vagina to capture images of the cervix, which are on par with that of a state of the art colposcope, at a fraction of the cost. A repository of images to be compiled that can be used to empower front line workers to become more effective through virtual dynamic training. By task shifting to the community setting, this technology could potentially provide significantly greater cervical screening access to where the most vulnerable women live. The POCkeT Colposcope’s concentric LED ring provides comparable white and green field illumination at a fraction of the electrical power required in commercial colposcopes. Evaluation with standard optical imaging targets to assess the POCkeT Colposcope against the state of the art digital colposcope and other VIAM technologies. Results Our POCkeT Colposcope has comparable resolving power, color reproduction accuracy, minimal lens distortion, and illumination when compared to commercially available colposcopes. In vitro and pilot in vivo imaging results are promising with our POCkeT Colposcope capturing comparable quality images to commercial systems. Conclusion The POCkeT Colposcope is capable of capturing images suitable for cervical lesion analysis. Our portable low cost system could potentially increase access to cervical cancer screening in limited resource settings through task shifting to community

  1. Isoprene Emissions from Downy Oak under Water Limitation during an Entire Growing Season: What Cost for Growth?

    PubMed Central

    Genard-Zielinski, Anne-Cyrielle; Ormeño, Elena; Boissard, Christophe; Fernandez, Catherine

    2014-01-01

    Increases in the production of terpene- and phenolic-like compounds in plant species under abiotic stress conditions have been interpreted in physiological studies as a supplementary defense system due to their capacity to limit cell oxidation. From an ecological perspective however, these increases are only expected to confer competitive advantages if they do not imply a significant cost for the plant, that is, growth reduction. We investigated shifts of isoprene emissions, and to a lesser extent phenolic compound concentration, of Quercus pubescens Willd. from early leaf development to leaf senescence under optimal watering (control: C), mild and severe water stress (MS, SS). The impact of water stress was concomitantly assessed on plant physiological (chlorophyll fluorescence, stomatal conductance, net photosynthesis, water potential) functional (relative leaf water content, leaf mass per area ratio) and growth (aerial and root biomass) traits. Growth changes allowed to estimate the eventual costs related to the production of isoprene and phenolics. The total phenolic content was not modified under water stress whereas isoprene emissions were promoted under MS over the entire growing cycle despite the decline of Pn by 35%. Under SS, isoprene emissions remained similar to C all over the study despite the decline of Pn by 47% and were thereby clearly uncoupled to Pn leading to an overestimation of the isoprene emission factor by 44%. Under SS, maintenance of isoprene emissions and phenolic compound concentration resulted in very significant costs for the plants as growth rates were very significantly reduced. Under MS, increases of isoprene emission and maintenance of phenolic compound concentration resulted in moderate growth reduction. Hence, it is likely that investment in isoprene emissions confers Q. pubescens an important competitive advantage during moderate but not severe periods of water scarcity. Consequences of this response for air quality in North

  2. Isoprene emissions from downy oak under water limitation during an entire growing season: what cost for growth?

    PubMed

    Genard-Zielinski, Anne-Cyrielle; Ormeño, Elena; Boissard, Christophe; Fernandez, Catherine

    2014-01-01

    Increases in the production of terpene- and phenolic-like compounds in plant species under abiotic stress conditions have been interpreted in physiological studies as a supplementary defense system due to their capacity to limit cell oxidation. From an ecological perspective however, these increases are only expected to confer competitive advantages if they do not imply a significant cost for the plant, that is, growth reduction. We investigated shifts of isoprene emissions, and to a lesser extent phenolic compound concentration, of Quercus pubescens Willd. from early leaf development to leaf senescence under optimal watering (control: C), mild and severe water stress (MS, SS). The impact of water stress was concomitantly assessed on plant physiological (chlorophyll fluorescence, stomatal conductance, net photosynthesis, water potential) functional (relative leaf water content, leaf mass per area ratio) and growth (aerial and root biomass) traits. Growth changes allowed to estimate the eventual costs related to the production of isoprene and phenolics. The total phenolic content was not modified under water stress whereas isoprene emissions were promoted under MS over the entire growing cycle despite the decline of Pn by 35%. Under SS, isoprene emissions remained similar to C all over the study despite the decline of Pn by 47% and were thereby clearly uncoupled to Pn leading to an overestimation of the isoprene emission factor by 44%. Under SS, maintenance of isoprene emissions and phenolic compound concentration resulted in very significant costs for the plants as growth rates were very significantly reduced. Under MS, increases of isoprene emission and maintenance of phenolic compound concentration resulted in moderate growth reduction. Hence, it is likely that investment in isoprene emissions confers Q. pubescens an important competitive advantage during moderate but not severe periods of water scarcity. Consequences of this response for air quality in North

  3. Regulatory and cost barriers are likely to limit biosimilar development and expected savings in the near future.

    PubMed

    Grabowski, Henry G; Guha, Rahul; Salgado, Maria

    2014-06-01

    In March 2010 Congress established an abbreviated Food and Drug Administration approval pathway for biosimilars-drugs that are very similar but not identical to a reference biological product and cost less. Because bringing biosimilars to the market currently requires large investments of money, fewer biosimilars are expected to enter the biologics market than has been the case with generic drugs entering the small-molecule drug market. Additionally, given the high regulatory hurdles to obtaining interchangeability-which would allow pharmacists to substitute a biosimilar for its reference product, subject to evolving state substitution laws-most biosimilars will likely compete as therapeutic alternatives instead of as therapeutic equivalents. In other words, biosimilars will need to compete with their reference product on the basis of quality; price; and manufacturer's reputation with physicians, insurers, and patient groups. Biosimilars also will face dynamic competition from new biologics in the same therapeutic class-including "biobetters," which offer incremental improvements on reference products, such as extended duration of action. The prospects for significant cost savings from the use of biosimilars appear to be limited for the next several years, but their use should increase over time because of both demand- and supply-side factors.

  4. Regulatory and cost barriers are likely to limit biosimilar development and expected savings in the near future.

    PubMed

    Grabowski, Henry G; Guha, Rahul; Salgado, Maria

    2014-06-01

    In March 2010 Congress established an abbreviated Food and Drug Administration approval pathway for biosimilars-drugs that are very similar but not identical to a reference biological product and cost less. Because bringing biosimilars to the market currently requires large investments of money, fewer biosimilars are expected to enter the biologics market than has been the case with generic drugs entering the small-molecule drug market. Additionally, given the high regulatory hurdles to obtaining interchangeability-which would allow pharmacists to substitute a biosimilar for its reference product, subject to evolving state substitution laws-most biosimilars will likely compete as therapeutic alternatives instead of as therapeutic equivalents. In other words, biosimilars will need to compete with their reference product on the basis of quality; price; and manufacturer's reputation with physicians, insurers, and patient groups. Biosimilars also will face dynamic competition from new biologics in the same therapeutic class-including "biobetters," which offer incremental improvements on reference products, such as extended duration of action. The prospects for significant cost savings from the use of biosimilars appear to be limited for the next several years, but their use should increase over time because of both demand- and supply-side factors. PMID:24889955

  5. 42 CFR 413.235 - Patient-level adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.235 Patient-level adjustments. Adjustments to... reflect patient characteristics that result in higher costs for ESRD facilities. (a) CMS adjusts the...

  6. 42 CFR 413.235 - Patient-level adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.235 Patient-level adjustments. Adjustments to... reflect patient characteristics that result in higher costs for ESRD facilities. (a) CMS adjusts the...

  7. 42 CFR 413.235 - Patient-level adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.235 Patient-level adjustments. Adjustments to... reflect patient characteristics that result in higher costs for ESRD facilities. (a) CMS adjusts the...

  8. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... conveyance and/or recordation fees and taxes. (5) Reasonable closing costs. (6) Fees for management services... accounting principles. (2) Closing fees, application fees, and expense reimbursements, each as permitted... limitations on fees charged to Small Businesses (âCost of Moneyâ). 107.855 Section 107.855 Business Credit...

  9. Can they recover? An assessment of adult adjustment problems among males in the abstainer, recovery, life-course persistent, and adolescence-limited pathways followed up to age 56 in the Cambridge Study in Delinquent Development.

    PubMed

    Jennings, Wesley G; Rocque, Michael; Fox, Bryanna Hahn; Piquero, Alex R; Farrington, David P

    2016-05-01

    Much research has examined Moffitt's developmental taxonomy, focusing almost exclusively on the distinction between life-course persistent and adolescence-limited offenders. Of interest, a handful of studies have identified a group of individuals whose early childhood years were marked by extensive antisocial behavior but who seemed to recover and desist (at least from severe offending) in adolescence and early adulthood. We use data from the Cambridge Study in Delinquent Development to examine the adult adjustment outcomes of different groups of offenders, including a recoveries group, in late middle adulthood, offering the most comprehensive investigation of this particular group to date. Findings indicate that abstainers comprise the largest group of males followed by adolescence-limited offenders, recoveries, and life-course persistent offenders. Furthermore, the results reveal that a host of adult adjustment problems measured at ages 32 and 48 in a number of life-course domains are differentially distributed across these four offender groups. In addition, the recoveries and life-course persistent offenders often show the greatest number of adult adjustment problems relative to the adolescence-limited offenders and abstainers.

  10. A novel methodology for estimating upper limits of major cost drivers for profitable conceptual launch system architectures

    NASA Astrophysics Data System (ADS)

    Rhodes, Russel E.; Byrd, Raymond J.

    1998-01-01

    This paper presents a ``back of the envelope'' technique for fast, timely, on-the-spot, assessment of affordability (profitability) of commercial space transportation architectural concepts. The tool presented here is not intended to replace conventional, detailed costing methodology. The process described enables ``quick look'' estimations and assumptions to effectively determine whether an initial concept (with its attendant cost estimating line items) provides focus for major leapfrog improvement. The Cost Charts Users Guide provides a generic sample tutorial, building an approximate understanding of the basic launch system cost factors and their representative magnitudes. This process will enable the user to develop a net ``cost (and price) per payload-mass unit to orbit'' incorporating a variety of significant cost drivers, supplemental to basic vehicle cost estimates. If acquisition cost and recurring cost factors (as a function of cost per payload-mass unit to orbit) do not meet the predetermined system-profitability goal, the concept in question will be clearly seen as non-competitive. Multiple analytical approaches, and applications of a variety of interrelated assumptions, can be examined in a quick, (on-the-spot) cost approximation analysis as this tool has inherent flexibility. The technique will allow determination of concept conformance to system objectives.

  11. A brief review of the estimated economic burden of sexually transmitted diseases in the United States: inflation-adjusted updates of previously published cost studies.

    PubMed

    Chesson, Harrell W; Gift, Thomas L; Owusu-Edusei, Kwame; Tao, Guoyu; Johnson, Ana P; Kent, Charlotte K

    2011-10-01

    We conducted a literature review of studies of the economic burden of sexually transmitted diseases in the United States. The annual direct medical cost of sexually transmitted diseases (including human immunodeficiency virus) has been estimated to be $16.9 billion (range: $13.9-$23.0 billion) in 2010 US dollars.

  12. Cost-effective particulate control options at Potomac Electric Power Company's Dickerson Station: An integrated approach to current and future particulate limits

    SciTech Connect

    Christoffersen, S.W.; Rouse, G.T.; Krasnopoler, M.J.; Chapowski, J.A.

    1998-07-01

    The Dickerson Generating Station evaluated several particulate control options to identify the most cost-effective option. The study's goals were to: eliminate the particulate scrubber and its high maintenance costs, and incorporate flexibility for low-sulfur coal and possible stricter emission limits. Each of the three Dickerson 190 MW units has a small 37-year-old electrostatic precipitator and a wet particulate scrubber. The study evaluated alternatives to replace the scrubber and enhance ESP performance: Existing ESP alternatives--Extend height of existing ESP; Flue gas conditioning. Scrubber stream alternatives--Partial-flow ESP or pulse jet baghouse. Full-flow alternatives--Supplemental ESP; COHPAC baghouse; replacement ESP or baghouse. A technical and economic prescreening eliminated some of the options. Capital, operating, and life cycle costs were estimated for the remaining options to determine the most cost-effective alternative. This paper will present the technical and economic evaluations done for this study, including performance and costs.

  13. 26 CFR 1.1059A-1 - Limitation on taxpayer's basis or inventory cost in property imported from related persons.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... for— (i) Freight charges, (ii) Insurance charges, (iii) The construction, erection, assembly, or... CFR 152.103(e). When 19 CFR 152.103(e) has been utilized for customs purposes, the taxpayer may adjust... $150 for ocean freight and insurance. The customs value of the shipment is determined to be the...

  14. 26 CFR 1.1059A-1 - Limitation on taxpayer's basis or inventory cost in property imported from related persons.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... for— (i) Freight charges, (ii) Insurance charges, (iii) The construction, erection, assembly, or... CFR 152.103(e). When 19 CFR 152.103(e) has been utilized for customs purposes, the taxpayer may adjust... $150 for ocean freight and insurance. The customs value of the shipment is determined to be the...

  15. 26 CFR 1.1059A-1 - Limitation on taxpayer's basis or inventory cost in property imported from related persons.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for— (i) Freight charges, (ii) Insurance charges, (iii) The construction, erection, assembly, or... CFR 152.103(e). When 19 CFR 152.103(e) has been utilized for customs purposes, the taxpayer may adjust... $150 for ocean freight and insurance. The customs value of the shipment is determined to be the...

  16. 26 CFR 1.1059A-1 - Limitation on taxpayer's basis or inventory cost in property imported from related persons.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for— (i) Freight charges, (ii) Insurance charges, (iii) The construction, erection, assembly, or... CFR 152.103(e). When 19 CFR 152.103(e) has been utilized for customs purposes, the taxpayer may adjust... $150 for ocean freight and insurance. The customs value of the shipment is determined to be the...

  17. Shaft adjuster

    DOEpatents

    Harry, H.H.

    1988-03-11

    Abstract and method for the adjustment and alignment of shafts in high power devices. A plurality of adjacent rotatable angled cylinders are positioned between a base and the shaft to be aligned which when rotated introduce an axial offset. The apparatus is electrically conductive and constructed of a structurally rigid material. The angled cylinders allow the shaft such as the center conductor in a pulse line machine to be offset in any desired alignment position within the range of the apparatus. 3 figs.

  18. Shaft adjuster

    DOEpatents

    Harry, Herbert H.

    1989-01-01

    Apparatus and method for the adjustment and alignment of shafts in high power devices. A plurality of adjacent rotatable angled cylinders are positioned between a base and the shaft to be aligned which when rotated introduce an axial offset. The apparatus is electrically conductive and constructed of a structurally rigid material. The angled cylinders allow the shaft such as the center conductor in a pulse line machine to be offset in any desired alignment position within the range of the apparatus.

  19. Detection limits and cost comparisons of human- and gull-associated conventional and quantitative PCR assays in artificial and environmental waters.

    PubMed

    Riedel, Timothy E; Zimmer-Faust, Amity G; Thulsiraj, Vanessa; Madi, Tania; Hanley, Kaitlyn T; Ebentier, Darcy L; Byappanahalli, Muruleedhara; Layton, Blythe; Raith, Meredith; Boehm, Alexandria B; Griffith, John F; Holden, Patricia A; Shanks, Orin C; Weisberg, Stephen B; Jay, Jennifer A

    2014-04-01

    Some molecular methods for tracking fecal pollution in environmental waters have both PCR and quantitative PCR (qPCR) assays available for use. To assist managers in deciding whether to implement newer qPCR techniques in routine monitoring programs, we compared detection limits (LODs) and costs of PCR and qPCR assays with identical targets that are relevant to beach water quality assessment. For human-associated assays targeting Bacteroidales HF183 genetic marker, qPCR LODs were 70 times lower and there was no effect of target matrix (artificial freshwater, environmental creek water, and environmental marine water) on PCR or qPCR LODs. The PCR startup and annual costs were the lowest, while the per reaction cost was 62% lower than the Taqman based qPCR and 180% higher than the SYBR based qPCR. For gull-associated assays, there was no significant difference between PCR and qPCR LODs, target matrix did not effect PCR or qPCR LODs, and PCR startup, annual, and per reaction costs were lower. Upgrading to qPCR involves greater startup and annual costs, but this increase may be justified in the case of the human-associated assays with lower detection limits and reduced cost per sample.

  20. Detection limits and cost comparisons of human- and gull-associated conventional and quantitative PCR assays in artificial and environmental waters

    USGS Publications Warehouse

    Riedel, Timothy E.; Zimmer-Faust, Amity G.; Thulsiraj, Vanessa; Madi, Tania; Hanley, Kaitlyn T.; Ebentier, Darcy L.; Byappanahalli, Muruleedhara N.; Layton, Blythe; Raith, Meredith; Boehm, Alexandria B.; Griffith, John F.; Holden, Patricia A.; Shanks, Orin C.; Weisberg, Stephen B.; Jay, Jennifer A.

    2014-01-01

    Some molecular methods for tracking fecal pollution in environmental waters have both PCR and quantitative PCR (qPCR) assays available for use. To assist managers in deciding whether to implement newer qPCR techniques in routine monitoring programs, we compared detection limits (LODs) and costs of PCR and qPCR assays with identical targets that are relevant to beach water quality assessment. For human-associated assays targeting Bacteroidales HF183 genetic marker, qPCR LODs were 70 times lower and there was no effect of target matrix (artificial freshwater, environmental creek water, and environmental marine water) on PCR or qPCR LODs. The PCR startup and annual costs were the lowest, while the per reaction cost was 62% lower than the Taqman based qPCR and 180% higher than the SYBR based qPCR. For gull-associated assays, there was no significant difference between PCR and qPCR LODs, target matrix did not effect PCR or qPCR LODs, and PCR startup, annual, and per reaction costs were lower. Upgrading to qPCR involves greater startup and annual costs, but this increase may be justified in the case of the human-associated assays with lower detection limits and reduced cost per sample.

  1. 45 CFR 263.13 - Is there a limit on the amount of Federal TANF funds that a State may spend on administrative costs?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Is there a limit on the amount of Federal TANF funds that a State may spend on administrative costs? 263.13 Section 263.13 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND...

  2. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... limitations on fees charged to Small Businesses (âCost of Moneyâ). 107.855 Section 107.855 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Financing of Small Businesses by Licensees Structuring Licensee's Financing of An Eligible Small Business: Terms and Conditions of......

  3. 45 CFR 263.13 - Is there a limit on the amount of Federal TANF funds that a State may spend on administrative costs?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Is there a limit on the amount of Federal TANF funds that a State may spend on administrative costs? 263.13 Section 263.13 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND...

  4. Clinical consequences and cost of limiting use of vancomycin for perioperative prophylaxis: example of coronary artery bypass surgery.

    PubMed Central

    Zanetti, G.; Goldie, S. J.; Platt, R.

    2001-01-01

    Routine us of vancomycin for perioperative prophylaxis is discouraged, principally to minimize microbial resistance to it. However, outcomes and costs of this recommendation have not been assessed. We used decision-analytic models to compare clinical results and cost-effectiveness of no prophylaxis, cefazolin, and vancomycin, in coronary artery bypass graft surgery. In the base case, vancomycin resulted in 7% fewer surgical site infections and 1% lower all-cause mortality and saved $117 per procedure, compared with cefazolin. Cefazolin, in turn, resulted in substantially fewer infections and deaths and lower costs than no prophylaxis. We conclude that perioperative antibiotic prophylaxis with vancomycin is usually more effective and less expensive than cefazolin. Data on vancomycin's impact on resistance are needed to quantify the trade-off between individual patients' improved clinical outcomes and lower costs and the future long-term consequences to society. PMID:11747694

  5. Phenotype adjustment promotes adaptive evolution in a game without conflict.

    PubMed

    Yamaguchi, Sachi; Iwasa, Yoh

    2015-06-01

    Organisms may adjust their phenotypes in response to social and physical environments. Such phenotypic plasticity is known to help or retard adaptive evolution. Here, we study the evolutionary outcomes of adaptive phenotypic plasticity in an evolutionary game involving two players who have no conflicts of interest. A possible example is the growth and sex allocation of a lifelong pair of shrimps entrapped in the body of a sponge. We consider random pair formation, the limitation of total resources for growth, and the needs of male investment to fertilize eggs laid by the partner. We compare the following three different evolutionary dynamics: (1) No adjustment: each individual develops a phenotype specified by its own genotype; (2) One-player adjustment: the phenotype of the first player is specified by its own genotype, and the second player chooses the phenotype that maximizes its own fitness; (3) Two-player adjustment: the first player exhibits an initial phenotype specified by its own genotype, the second player chooses a phenotype given that of the first player, and finally, the first player readjusts its phenotype given that of the second player. We demonstrate that both one-player and two-player adjustments evolve to achieve maximum fitness. In contrast, the dynamics without adjustment fails in some cases to evolve outcomes with the highest fitness. For an intermediate range of male cost, the evolution of no adjustment realizes two hermaphrodites with equal size, whereas the one-player and two-player adjustments realize a small male and a large female.

  6. Self-adjustable glasses in the developing world.

    PubMed

    Gudlavalleti, Venkata S Murthy; Allagh, Komal Preet; Gudlavalleti, Aashrai Sv

    2014-01-01

    Uncorrected refractive errors are the single largest cause of visual impairment globally. Refractive errors are an avoidable cause of visual impairment that are easily correctable. Provision of spectacles is a cost-effective measure. Unfortunately, this simple solution becomes a public health challenge in low- and middle-income countries because of the paucity of human resources for refraction and optical services, lack of access to refraction services in rural areas, and the cost of spectacles. Low-cost approaches to provide affordable glasses in developing countries are critical. A number of approaches has been tried to surmount the challenge, including ready-made spectacles, the use of focometers and self-adjustable glasses, among other modalities. Recently, self-adjustable spectacles have been validated in studies in both children and adults in developed and developing countries. A high degree of agreement between self-adjustable spectacles and cycloplegic subjective refraction has been reported. Self-refraction has also been found to be less prone to accommodative inaccuracy compared with non-cycloplegic autorefraction. The benefits of self-adjusted spectacles include: the potential for correction of both distance and near vision, applicability for all ages, the empowerment of lay workers, the increased participation of clients, augmented awareness of the mechanism of refraction, reduced costs of optical and refraction units in low-resource settings, and a relative reduction in costs for refraction services. Concerns requiring attention include a need for the improved cosmetic appearance of the currently available self-adjustable spectacles, an increased range of correction (currently -6 to +6 diopters), compliance with international standards, quality and affordability, and the likely impact on health systems. Self-adjustable spectacles show poor agreement with conventional refraction methods for high myopia and are unable to correct astigmatism. A limitation

  7. Potential Impact of a Free Online HIV Treatment Response Prediction System for Reducing Virological Failures and Drug Costs after Antiretroviral Therapy Failure in a Resource-Limited Setting

    PubMed Central

    Revell, Andrew D.; Wang, Dechao; Pozniak, Anton; Montaner, Julio S.; Lane, H. Clifford; Larder, Brendan A.

    2013-01-01

    Objective. Antiretroviral drug selection in resource-limited settings is often dictated by strict protocols as part of a public health strategy. The objective of this retrospective study was to examine if the HIV-TRePS online treatment prediction tool could help reduce treatment failure and drug costs in such settings. Methods. The HIV-TRePS computational models were used to predict the probability of response to therapy for 206 cases of treatment change following failure in India. The models were used to identify alternative locally available 3-drug regimens, which were predicted to be effective. The costs of these regimens were compared to those actually used in the clinic. Results. The models predicted the responses to treatment of the cases with an accuracy of 0.64. The models identified alternative drug regimens that were predicted to result in improved virological response and lower costs than those used in the clinic in 85% of the cases. The average annual cost saving was $364 USD per year (41%). Conclusions. Computational models that do not require a genotype can predict and potentially avoid treatment failure and may reduce therapy costs. The use of such a system to guide therapeutic decision-making could confer health economic benefits in resource-limited settings. PMID:24175292

  8. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, HEAD START PROGRAM HEAD START GRANTS ADMINISTRATION Personnel... and component training and transportation for staff, parents and volunteers; (2) Costs of functions... associated with parent involvement and component volunteer services; and (4) Expenses related to...

  9. 45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...'s share of program costs? 2521.45 Section 2521.45 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE ELIGIBLE AMERICORPS SUBTITLE C PROGRAM APPLICANTS AND TYPES OF GRANTS AVAILABLE FOR AWARD Program Matching Requirements § 2521.45 What are...

  10. Educational Costs.

    ERIC Educational Resources Information Center

    Arnold, Robert

    Problems in educational cost accounting and a new cost accounting approach are described in this paper. The limitations of the individualized cost (student units) approach and the comparative cost approach (in the form of fund-function-object) are illustrated. A new strategy, an activity-based system of accounting, is advocated. Borrowed from…

  11. 42 CFR 415.70 - Limits on compensation for physician services in providers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., professional memberships, and continuing medical education. (1) For the costs of membership in professional societies and continuing medical education, the intermediary may adjust the limit by the lesser of— (i)...

  12. Accuracy of a Low-Cost Novel Computer-Vision Dynamic Movement Assessment: Potential Limitations and Future Directions

    NASA Astrophysics Data System (ADS)

    McGroarty, M.; Giblin, S.; Meldrum, D.; Wetterling, F.

    2016-04-01

    The aim of the study was to perform a preliminary validation of a low cost markerless motion capture system (CAPTURE) against an industry gold standard (Vicon). Measurements of knee valgus and flexion during the performance of a countermovement jump (CMJ) between CAPTURE and Vicon were compared. After correction algorithms were applied to the raw CAPTURE data acceptable levels of accuracy and precision were achieved. The knee flexion angle measured for three trials using Capture deviated by -3.8° ± 3° (left) and 1.7° ± 2.8° (right) compared to Vicon. The findings suggest that low-cost markerless motion capture has potential to provide an objective method for assessing lower limb jump and landing mechanics in an applied sports setting. Furthermore, the outcome of the study warrants the need for future research to examine more fully the potential implications of the use of low-cost markerless motion capture in the evaluation of dynamic movement for injury prevention.

  13. The assessment of social adjustment. A review of techniques.

    PubMed

    Weissman, M M

    1975-03-01

    Interest in the community adjustment of psychiatric patients has led to the development of rating techniques for its evaluation. Selection of an appropriate scale for the task should include a review of its item content, anchor points, coverage, method of obtaining information, informant, psychometric properties, precision, cost, scoring, and instructional material. While no scale is without limitations, this report describes 15 currently available scales that meet many of the important criteria for assessing social adjustment and are sufficiently developed to be useful in evaluative research. This review also contains a list of pertinent references to the scales and guide to the literature on behavioral rating scales.

  14. [The medical autopsy: its indications, contraindications, the modalities of its implementation, its cost and its limits. Autopsy of the medical autopsy].

    PubMed

    Duband, Sébastien; Bidat, Carolyne; Forest, Fabien; Béraud, Jean-Michel; Méjean, Franck; Dumollard, Jean-Marc; Péoc'h, Michel

    2012-02-01

    The decline of the medical autopsy, in spite of the uncontested recognition of its utility, is not to be any more proved. By summarizing the legal frame of this exceptional act, we tried to identify the indications, the contraindications, the precautions for use, the limits, the technical, legal and ethical constraints and the costs of this diagnostic and therapeutic tool. The discussion underlines that the main brake in the realization of the autopsies could be its too strict French legal frame.

  15. Medicaid program; cost limit for providers operated by units of government and provisions to ensure the integrity of federal-state financial partnership. Final rule with comment period.

    PubMed

    2007-05-29

    This regulation clarifies that entities involved in the financing of the non-Federal share of Medicaid payments must be a unit of government; clarifies the documentation required to support a Medicaid certified public expenditure; limits Medicaid reimbursement for health care providers that are operated by units of government to an amount that does not exceed the health care provider's cost of providing services to Medicaid individuals; requires all health care providers to receive and retain the full amount of total computable payments for services furnished under the approved Medicaid State plan; and makes conforming changes to provisions governing the State Child Health Insurance Program (SCHIP) to make the same requirements applicable, with the exception of the cost limit on reimbursement. The Medicaid cost limit provision of this regulation does not apply to: Stand-alone SCHIP program payments made to governmentally-operated health care providers; Indian Health Service (IHS) facilities and tribal 638 facilities that are paid at the all-inclusive IHS rate; Medicaid Managed Care Organizations (MCOs), Prepaid Inpatient Health Plans (PIHPs), and Prepaid Ambulatory Health Plans (PAHPs); Federally Qualified Health Centers (FQHCs) and Rural Health Clinics (RHCs). Moreover, disproportionate share hospital (DSH) payments and payments authorized under Section 701(d) and Section 705 of the Benefits Improvement Protection Act of 2000 are not subject to the newly established Medicaid cost limit for governmentally-operated health care providers. Except as noted above, all Medicaid payments and SCHIP payments made under the authority of the State plan and under waiver and demonstration authorities, as well as associated State Medicaid and SCHIP financing arrangements, are subject to all provisions of this regulation. Finally, this regulation solicits comments from the public on issues related to the definition of the Unit of Government.

  16. 7 CFR 636.7 - Cost-share payments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for payment in accordance with 7 CFR part 1400, subpart G, average adjusted gross income limitation... AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVES PROGRAM § 636.7 Cost-share payments. (a) NRCS... establishing conservation practices to develop fish and wildlife habitat. The cost-share payment to...

  17. 48 CFR 2152.231-70 - Accounting and allowable cost.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... audit must be performed in accordance with Generally Accepted Government Auditing Standards or other... Government audit, the FEGLI contract may be: (i) Adjusted by amounts found not to constitute chargeable costs... the limit on indirect costs for the following contract year. During a continuity of services...

  18. The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis

    PubMed Central

    Hyle, Emily P.; Jani, Ilesh V.; Lehe, Jonathan; Su, Amanda E.; Wood, Robin; Quevedo, Jorge; Losina, Elena; Bassett, Ingrid V.; Pei, Pamela P.; Paltiel, A. David; Resch, Stephen; Freedberg, Kenneth A.; Peter, Trevor; Walensky, Rochelle P.

    2014-01-01

    Background Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to laboratory-based tests in Mozambique. Methods and Findings We use a validated model of HIV testing, linkage, and treatment (CEPAC-International) to examine two strategies of immunological staging in Mozambique: (1) laboratory-based CD4 testing (LAB-CD4) and (2) point-of-care CD4 testing (POC-CD4). Model outcomes include 5-y survival, life expectancy, lifetime costs, and incremental cost-effectiveness ratios (ICERs). Input parameters include linkage to care (LAB-CD4, 34%; POC-CD4, 61%), probability of correctly detecting antiretroviral therapy (ART) eligibility (sensitivity: LAB-CD4, 100%; POC-CD4, 90%) or ART ineligibility (specificity: LAB-CD4, 100%; POC-CD4, 85%), and test cost (LAB-CD4, US$10; POC-CD4, US$24). In sensitivity analyses, we vary POC-CD4-specific parameters, as well as cohort and setting parameters to reflect a range of scenarios in sub-Saharan Africa. We consider ICERs less than three times the per capita gross domestic product in Mozambique (US$570) to be cost-effective, and ICERs less than one times the per capita gross domestic product in Mozambique to be very cost-effective. Projected 5-y survival in HIV-infected persons with LAB-CD4 is 60.9% (95% CI, 60.9%–61.0%), increasing to 65.0% (95% CI, 64.9%–65.1%) with POC-CD4. Discounted life expectancy and per person lifetime costs with LAB-CD4 are 9.6 y (95% CI, 9.6–9.6 y) and US$2,440 (95% CI, US$2,440–US$2,450) and increase with POC-CD4 to 10.3 y (95% CI, 10.3–10.3 y) and US$2,800 (95% CI, US$2,790–US$2,800); the ICER of POC-CD4 compared to LAB-CD4 is US$500/year of life saved (YLS) (95% CI, US$480–US$520/YLS). POC-CD4 improves clinical outcomes and remains near the very cost-effective threshold in sensitivity analyses, even if point-of-care CD4 tests have lower sensitivity

  19. Adjustable link for kinematic mounting systems

    DOEpatents

    Hale, Layton C.

    1997-01-01

    An adjustable link for kinematic mounting systems. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two.

  20. Adjustable link for kinematic mounting systems

    DOEpatents

    Hale, L.C.

    1997-07-01

    An adjustable link for kinematic mounting systems is disclosed. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two. 3 figs.

  1. Generation cost frontier analysis, dynamic market adjustment, and strategic gaming: Integrated tools for benchmarking, competitive market analysis, and strategy formulation under conditions of uncertainty in the transition to a competitive electricity market

    SciTech Connect

    Corio, M.R.; Bellucci, J.W.; Boyd, G.A.; Perl, K.E.

    1998-07-01

    The authors describe a three dimensional frontier consisting of: spending, availability/reliability, and utilization/heat rate. To determine optimal behavior in a future deregulated market, one must also find the optimal adjustment path from present to long-run frontier operation, and the optimal strategic action/response as determined by game theory. One can also perform more limited optimizations along either the two dimensional spending/reliability or spending/utilization frontiers. Although the authors mainly discuss optimizing existing domestic plants, frontier analysis could easily be applied to an electric producer's plants or acquisition targets internationally. Efficient operation saves money even in countries where electric markets are still regulated and can also confer indirect environmental benefits. AER is also applying these frontier analysis and game theory techniques to environmental decision-making, specifically to environmental retrofit decisions.

  2. Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventions

    PubMed Central

    2011-01-01

    Early infant diagnosis (EID) of HIV-1 infection confers substantial benefits to HIV-infected and HIV-uninfected infants, to their families, and to programs providing prevention of mother-to-child transmission (PMTCT) services, but has been challenging to implement in resource-limited settings. In order to correctly inform parents/caregivers of infant infection status and link HIV-infected infants to care and treatment, a 'cascade' of events must successfully occur. A frequently cited barrier to expansion of EID programs is the cost of the required laboratory assays. However, substantial implementation barriers, as well as personnel and infrastructure requirements, exist at each step in the cascade. In this update, we review challenges to uptake at each step in the EID cascade, highlighting that even with the highest reported levels of uptake, nearly half of HIV-infected infants may not complete the cascade successfully. We next synthesize the available literature about the costs and cost effectiveness of EID programs; identify areas for future research; and place these findings within the context of the benefits and challenges to EID implementation in resource-limited settings. PMID:21599888

  3. Genotype assays and third-line ART in resource-limited settings: A simulation and cost-effectiveness analysis of a planned clinical trial

    PubMed Central

    Lorenzana, Sarah B.; Hughes, Michael D.; Grinsztejn, Beatriz; Collier, Ann C.; Luz, Paula Mendes; Freedberg, Kenneth A.; Wood, Robin; Levison, Julie H.; Mugyenyi, Peter N.; Salata, Robert; Wallis, Carole L.; Weinstein, Milton C.; Schooley, Robert T.; Walensky, Rochelle P.

    2012-01-01

    Objectives To project the clinical and economic outcomes of a genotype assay for selection of third-line antiretroviral therapy (ART) in resource-limited settings, as per the planned international A5288 trial (MULTI-OCTAVE). Methods We used the Cost-effectiveness of Preventing AIDS Complications (CEPAC)-International Model to compare three strategies for subjects who have failed second-line ART in South Africa: (1) Sustained second-line: no genotype assay, all subjects remain on second-line ART; (2) A5288: genotype to determine the resistance profile and assign an appropriate regimen; or (3) Population-based third-line: no genotype, all subjects switch to a potent third-line regimen. Model inputs are from published data in South Africa. Resistance profiles, ART regimens, and efficacy data were those used for trial planning. Results Projected life expectancy for sustained second-line, A5288, and population-based third-line are 61.1, 103.8, and 104.2 months. Compared to sustained second-line ($12,460), per person lifetime costs increase for the A5288 ($39,250) and population-based ($44,120) strategies. The incremental cost-effectiveness ratio of A5288, compared to sustained second-line, is $7,500/year of life saved (YLS), and for population-based third-line, compared to A5288, is $154,500/YLS. In the A5288 strategy, very late presentation to care, coupled with lengthy delays to obtain the genotype, dramatically reduces 5-yr survival, making the population-based third-line strategy more attractive. Conclusions We project that, while the public health approach to third-line therapy is unaffordable, genotype assays and third-line ART in resource-limited settings will increase survival and be cost-effective compared to the population-based approach, supporting the value of an efficacy study. PMID:22343964

  4. Parental Divorce and Children's Adjustment.

    PubMed

    Lansford, Jennifer E

    2009-03-01

    This article reviews the research literature on links between parental divorce and children's short-term and long-term adjustment. First, I consider evidence regarding how divorce relates to children's externalizing behaviors, internalizing problems, academic achievement, and social relationships. Second, I examine timing of the divorce, demographic characteristics, children's adjustment prior to the divorce, and stigmatization as moderators of the links between divorce and children's adjustment. Third, I examine income, interparental conflict, parenting, and parents well-being as mediators of relations between divorce and children's adjustment. Fourth, I note the caveats and limitations of the research literature. Finally, I consider notable policies related to grounds for divorce, child support, and child custody in light of how they might affect children s adjustment to their parents divorce.

  5. 48 CFR 52.222-32 - Construction Wage Rate Requirements-Price Adjustment (Actual Method).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... include any allowance for any increased cost for which adjustment is being requested. (c) The Contracting... be limited to increases or decreases in wages and fringe benefits as described in paragraph (c) of... DBA craft New WD Hourly rate paid Diff. Actual hrs. Actual units (sq. yard) Increase/sq. yard...

  6. Using average cost methods to estimate encounter-level costs for medical-surgical stays in the VA.

    PubMed

    Wagner, Todd H; Chen, Shuo; Barnett, Paul G

    2003-09-01

    The U.S. Department of Veterans Affairs (VA) maintains discharge abstracts, but these do not include cost information. This article describes the methods the authors used to estimate the costs of VA medical-surgical hospitalizations in fiscal years 1998 to 2000. They estimated a cost regression with 1996 Medicare data restricted to veterans receiving VA care in an earlier year. The regression accounted for approximately 74 percent of the variance in cost-adjusted charges, and it proved to be robust to outliers and the year of input data. The beta coefficients from the cost regression were used to impute costs of VA medical-surgical hospital discharges. The estimated aggregate costs were reconciled with VA budget allocations. In addition to the direct medical costs, their cost estimates include indirect costs and physician services; both of these were allocated in proportion to direct costs. They discuss the method's limitations and application in other health care systems. PMID:15095543

  7. Optimising the manufacture, formulation, and dose of antiretroviral drugs for more cost-efficient delivery in resource-limited settings: a consensus statement.

    PubMed

    Crawford, Keith W; Ripin, David H Brown; Levin, Andrew D; Campbell, Jennifer R; Flexner, Charles

    2012-07-01

    It is expected that funding limitations for worldwide HIV treatment and prevention in resource-limited settings will continue, and, because the need for treatment scale-up is urgent, the emphasis on value for money has become an increasing priority. The Conference on Antiretroviral Drug Optimization--a collaborative project between the Clinton Health Access Initiative, the Johns Hopkins University School of Medicine, and the Bill & Melinda Gates Foundation--brought together process chemists, clinical pharmacologists, pharmaceutical scientists, physicians, pharmacists, and regulatory specialists to explore strategies for the reduction of antiretroviral drug costs. The antiretroviral drugs discussed were prioritised for consideration on the basis of their market impact, and the objectives of the conference were framed as discussion questions generated to guide scientific assessment of potential strategies. These strategies included modifications to the synthesis of the active pharmaceutical ingredient (API) and use of cheaper sources of raw materials in synthesis of these ingredients. Innovations in product formulation could improve bioavailability thus needing less API. For several antiretroviral drugs, studies show efficacy is maintained at doses below the approved dose (eg, efavirenz, lopinavir plus ritonavir, atazanavir, and darunavir). Optimising pharmacoenhancement and extending shelf life are additional strategies. The conference highlighted a range of interventions; optimum cost savings could be achieved through combining approaches. PMID:22742638

  8. Optimising the manufacture, formulation, and dose of antiretroviral drugs for more cost-efficient delivery in resource-limited settings: a consensus statement.

    PubMed

    Crawford, Keith W; Ripin, David H Brown; Levin, Andrew D; Campbell, Jennifer R; Flexner, Charles

    2012-07-01

    It is expected that funding limitations for worldwide HIV treatment and prevention in resource-limited settings will continue, and, because the need for treatment scale-up is urgent, the emphasis on value for money has become an increasing priority. The Conference on Antiretroviral Drug Optimization--a collaborative project between the Clinton Health Access Initiative, the Johns Hopkins University School of Medicine, and the Bill & Melinda Gates Foundation--brought together process chemists, clinical pharmacologists, pharmaceutical scientists, physicians, pharmacists, and regulatory specialists to explore strategies for the reduction of antiretroviral drug costs. The antiretroviral drugs discussed were prioritised for consideration on the basis of their market impact, and the objectives of the conference were framed as discussion questions generated to guide scientific assessment of potential strategies. These strategies included modifications to the synthesis of the active pharmaceutical ingredient (API) and use of cheaper sources of raw materials in synthesis of these ingredients. Innovations in product formulation could improve bioavailability thus needing less API. For several antiretroviral drugs, studies show efficacy is maintained at doses below the approved dose (eg, efavirenz, lopinavir plus ritonavir, atazanavir, and darunavir). Optimising pharmacoenhancement and extending shelf life are additional strategies. The conference highlighted a range of interventions; optimum cost savings could be achieved through combining approaches.

  9. Nonlinear relative-proportion-based route adjustment process for day-to-day traffic dynamics: modeling, equilibrium and stability analysis

    NASA Astrophysics Data System (ADS)

    Zhu, Wenlong; Ma, Shoufeng; Tian, Junfang; Li, Geng

    2016-11-01

    Travelers' route adjustment behaviors in a congested road traffic network are acknowledged as a dynamic game process between them. Existing Proportional-Switch Adjustment Process (PSAP) models have been extensively investigated to characterize travelers' route choice behaviors; PSAP has concise structure and intuitive behavior rule. Unfortunately most of which have some limitations, i.e., the flow over adjustment problem for the discrete PSAP model, the absolute cost differences route adjustment problem, etc. This paper proposes a relative-Proportion-based Route Adjustment Process (rePRAP) maintains the advantages of PSAP and overcomes these limitations. The rePRAP describes the situation that travelers on higher cost route switch to those with lower cost at the rate that is unilaterally depended on the relative cost differences between higher cost route and its alternatives. It is verified to be consistent with the principle of the rational behavior adjustment process. The equivalence among user equilibrium, stationary path flow pattern and stationary link flow pattern is established, which can be applied to judge whether a given network traffic flow has reached UE or not by detecting the stationary or non-stationary state of link flow pattern. The stability theorem is proved by the Lyapunov function approach. A simple example is tested to demonstrate the effectiveness of the rePRAP model.

  10. Can HIV reverse transcriptase activity assay be a low-cost alternative for viral load monitoring in resource-limited settings?

    PubMed Central

    Gupta, Soham; Palchaudhuri, Riya; Neogi, Ujjwal; Srinivasa, Hiresave; Ashorn, Per; De Costa, Ayesha; Källander, Clas; Shet, Anita

    2016-01-01

    Objective To evaluate the performance and cost of an HIV reverse transcriptase-enzyme activity (HIV-RT) assay in comparison to an HIV-1 RNA assay for routine viral load monitoring in resource limited settings. Design A cohort-based longitudinal study. Setting Two antiretroviral therapy (ART) centres in Karnataka state, South India, providing treatment under the Indian AIDS control programme. Participants A cohort of 327 HIV-1-infected Indian adult patients initiating first-line ART. Outcome measures Performance and cost of an HIV-RT assay (ExaVir Load V3) in comparison to a gold standard HIV-1 RNA assay (Abbott m2000rt) in a cohort of 327 Indian patients before (WK00) and 4 weeks (WK04) after initiation of first-line therapy. Results Plasma viral load was determined by an HIV-1 RNA assay and an HIV-RT assay in 629 samples (302 paired samples and 25 single time point samples at WK00) obtained from 327 patients. Overall, a strong correlation of r=0.96 was observed, with good correlation at WK00 (r=0.84) and at WK04 (r=0.77). Bland-Altman analysis of all samples showed a good level of agreement with a mean difference (bias) of 0.22 log10copies/mL. The performance of ExaVir Load V3 was not negatively affected by a nevirapine/efavirenz based antiretroviral regimen. The per test cost of measuring plasma viral load by the Abbott m2000rt and ExaVir Load V3 assays in a basic lab setting was $36.4 and $16.8, respectively. Conclusions The strong correlation between the HIV-RT and HIV-1 RNA assays suggests that the HIV-RT assay can be an affordable alternative option for monitoring patients on antiretroviral therapy in resource-limited settings. Trial registration number ISRCTN79261738. PMID:26817634

  11. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  12. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  13. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  14. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  15. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  16. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum, if... institution of higher education (IHE) to provide information on the cost of higher education to...

  17. Melt-and-mold fabrication (MnM-Fab) of reconfigurable low-cost devices for use in resource-limited settings.

    PubMed

    Li, Zhi; Tevis, Ian D; Oyola-Reynoso, Stephanie; Newcomb, Lucas B; Halbertsma-Black, Julian; Bloch, Jean-Francis; Thuo, Martin

    2015-12-01

    Interest in low-cost analytical devices (especially for diagnostics) has recently increased; however, concomitant translation to the field has been slow, in part due to personnel and supply-chain challenges in resource-limited settings. Overcoming some of these challenges require the development of a method that takes advantage of locally available resources and/or skills. We report a Melt-and-mold fabrication (MnM Fab) approach to low-cost and simple devices that has the potential to be adapted locally since it requires a single material that is recyclable and simple skills to access multiple devices. We demonstrated this potential by fabricating entry level bio-analytical devices using an affordable low-melting metal alloy, Field's metal, with molds produced from known materials such as plastic (acrylonitrile-butadiene-styrene (ABS)), glass, and paper. We fabricated optical gratings then 4×4 well plates using the same recycled piece of metal. We then reconfigured the well plates into rapid prototype microfluidic devices with which we demonstrated laminar flow, droplet generation, and bubble formation from T-shaped channels. We conclude that this MnM-Fab method is capable of addressing some challenges typically encountered with device translation, such as technical know-how or material supply, and that it can be applied to other devices, as needed in the field, using a single moldable material. PMID:26459439

  18. Low-cost and high-power-density resistive fault-current limiting elements using YBCO thin films and Au-Ag alloy shunt layers

    NASA Astrophysics Data System (ADS)

    Yamasaki, H.; Arai, K.; Furuse, M.; Kaiho, K.; Nakagawa, Y.

    2006-06-01

    We propose a new design for the high-temperature superconducting thin-film faultcurrent limiter (FCL), which uses high-resistivity Au-Ag alloy shunt layers instead of the pure gold (or silver) shunt layers conventionally used. An FCL element (5 mm wide and 40 mm long) with a YBCO thin film (THEVA) and a parallel inductively-wound shunt resistor successfully withstood very high electric field (> 44 Vpeak/cm) for 5 cycles (0.1 sec) after switching, and achieved a very high switching power density, ~2.0 kVA/cm2. We confirmed similar maximum tolerable electric field (>40 Vpeak/cm, limited by power supply) in a larger sample (1 cm × 6 cm). The composition of our FCL element is very simple, and the achieved power density is more than five times higher than conventional devices, which leads to a dramatic reduction in the amount of expensive superconducting thin films. We made a conceptual design and cost estimation of our FCL elements used in a typical 6.6 kV FCL.

  19. ADJUSTABLE DOUBLE PULSE GENERATOR

    DOEpatents

    Gratian, J.W.; Gratian, A.C.

    1961-08-01

    >A modulator pulse source having adjustable pulse width and adjustable pulse spacing is described. The generator consists of a cross coupled multivibrator having adjustable time constant circuitry in each leg, an adjustable differentiating circuit in the output of each leg, a mixing and rectifying circuit for combining the differentiated pulses and generating in its output a resultant sequence of negative pulses, and a final amplifying circuit for inverting and square-topping the pulses. (AEC)

  20. Estimating age-based antiretroviral therapy costs for HIV-infected children in resource-limited settings based on World Health Organization weight-based dosing recommendations

    PubMed Central

    2014-01-01

    Background Pediatric antiretroviral therapy (ART) has been shown to substantially reduce morbidity and mortality in HIV-infected infants and children. To accurately project program costs, analysts need accurate estimations of antiretroviral drug (ARV) costs for children. However, the costing of pediatric antiretroviral therapy is complicated by weight-based dosing recommendations which change as children grow. Methods We developed a step-by-step methodology for estimating the cost of pediatric ARV regimens for children ages 0–13 years old. The costing approach incorporates weight-based dosing recommendations to provide estimated ARV doses throughout childhood development. Published unit drug costs are then used to calculate average monthly drug costs. We compared our derived monthly ARV costs to published estimates to assess the accuracy of our methodology. Results The estimates of monthly ARV costs are provided for six commonly used first-line pediatric ARV regimens, considering three possible care scenarios. The costs derived in our analysis for children were fairly comparable to or slightly higher than available published ARV drug or regimen estimates. Conclusions The methodology described here can be used to provide an accurate estimation of pediatric ARV regimen costs for cost-effectiveness analysts to project the optimum packages of care for HIV-infected children, as well as for program administrators and budget analysts who wish to assess the feasibility of increasing pediatric ART availability in constrained budget environments. PMID:24885453

  1. 42 CFR 419.43 - Adjustments to national program payment and beneficiary copayment amounts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Payment adjustment for certain cancer hospitals.—(1) General rule. CMS provides for a payment adjustment... (PCR) before the cancer hospital payment adjustment (as determined by the Secretary at cost report...-cost ratio (PCR) before the cancer hospital payment adjustment (as determined by the Secretary at...

  2. 78 FR 63465 - Adjusting Civil Money Penalties for Inflation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... CORPORATION Adjusting Civil Money Penalties for Inflation AGENCY: Farm Credit System Insurance Corporation. ACTION: Notice. SUMMARY: This notice assesses the need for cost-of-living adjustments to the civil money.... Statutes Concerning Inflation Adjustment of Civil Money Penalties The Federal Civil Penalties...

  3. Risk-Adjustment Simulation: Plans May Have Incentives To Distort Mental Health And Substance Use Coverage

    PubMed Central

    Montz, Ellen; Layton, Tim; Busch, Alisa B.; Ellis, Randall P.; Rose, Sherri; McGuire, Thomas G.

    2016-01-01

    Under the Affordable Care Act, the risk-adjustment program is designed to compensate health plans for enrolling people with poorer health status so that plans compete on cost and quality rather than the avoidance of high-cost individuals. This study examined health plan incentives to limit covered services for mental health and substance use disorders under the risk-adjustment system used in the health insurance Marketplaces. Through a simulation of the program on a population constructed to reflect Marketplace enrollees, we analyzed the cost consequences for plans enrolling people with mental health and substance use disorders. Our assessment points to systematic underpayment to plans for people with these diagnoses. We document how Marketplace risk adjustment does not remove incentives for plans to limit coverage for services associated with mental health and substance use disorders. Adding mental health and substance use diagnoses used in Medicare Part D risk adjustment is one potential policy step toward addressing this problem in the Marketplaces. PMID:27269018

  4. 42 CFR 413.231 - Adjustment for wages.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES... Disease (ESRD) Services and Organ Procurement Costs § 413.231 Adjustment for wages. (a) CMS adjusts...

  5. 42 CFR 413.235 - Patient-level adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES... Disease (ESRD) Services and Organ Procurement Costs § 413.235 Patient-level adjustments. Adjustments...

  6. 42 CFR 413.232 - Low-volume adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES... Disease (ESRD) Services and Organ Procurement Costs § 413.232 Low-volume adjustment. (a) CMS adjusts...

  7. 42 CFR 413.232 - Low-volume adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES... Disease (ESRD) Services and Organ Procurement Costs § 413.232 Low-volume adjustment. (a) CMS adjusts...

  8. 42 CFR 413.235 - Patient-level adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES... Disease (ESRD) Services and Organ Procurement Costs § 413.235 Patient-level adjustments. Adjustments...

  9. 42 CFR 413.231 - Adjustment for wages.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE SERVICES... Disease (ESRD) Services and Organ Procurement Costs § 413.231 Adjustment for wages. (a) CMS adjusts...

  10. 42 CFR 413.231 - Adjustment for wages.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.231 Adjustment for wages. (a) CMS adjusts the... and wage-related costs in the geographic area in which the ESRD facility is located. (b) The application of the wage index is made on the basis of the location of the ESRD facility in an urban or...

  11. 42 CFR 413.231 - Adjustment for wages.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.231 Adjustment for wages. (a) CMS adjusts the... and wage-related costs in the geographic area in which the ESRD facility is located. (b) The application of the wage index is made on the basis of the location of the ESRD facility in an urban or...

  12. 42 CFR 413.231 - Adjustment for wages.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.231 Adjustment for wages. (a) CMS adjusts the... and wage-related costs in the geographic area in which the ESRD facility is located. (b) The application of the wage index is made on the basis of the location of the ESRD facility in an urban or...

  13. Magnetically Coupled Adjustable Speed Drive Systems

    SciTech Connect

    Chvala, William D.; Winiarski, David W.

    2002-08-18

    Adjustable speed drive (ASD) technologies have the ability to precisely control motor sytems output and produce a numbr of benefits including energy and demand savings. This report examines the performance and cost effectiveness of a specific class of ASDs called magnetically-coupled adjustable speed drives (MC-ASD) which use the strength of a magnetic field to control the amount of torque transferred between motor and drive shaft. The MagnaDrive Adjustable Speed Coupling System uses fixed rare-earth magnets and varies the distance between rotating plates in the assembly. the PAYBACK Variable Speed Drive uses an electromagnet to control the speed of the drive

  14. The application of EOQ and lead time crashing cost models in material with limited life time (Case study: CN-235 Aircraft at PT Dirgantara Indonesia)

    NASA Astrophysics Data System (ADS)

    Agustina Hidayat, Yosi; Ria Kasanah, Aprilia; Yudhistira, Titah

    2016-02-01

    PT. Dirgantara Indonesia, one of State Owned Enterprises engaging in the aerospace industry, targets to control 30% of world market for light and medium sized aircraft. One type of the aircrafts produced by PT. DI every year is CN-235. Currently, the cost of material procurement reaches 50% of the total cost of production. Material has a variety of characteristics, one of which is having a lifetime. The demand characteristic of the material with expiration for the CN-235 aircraft is deterministic. PT DI does not have any scientific background for its procurement of raw material policy. In addition, there are two methods of transportation used for delivering materials, i.e. by land and air. Each method has different lead time. Inventory policies used in this research are deterministic and probabilistic. Both deterministic and probabilistic single and multi-item inventory policies have order quantity, time to order, reorder point, and lead time as decision variables. The performance indicator for this research is total inventory cost. Inventory policy using the single item EOQ and considering expiration factor inventory results in a reduction in total costs up to 69.58% and multi item results in a decrease in total costs amounted to 71.16%. Inventory policy proposal using the model of a single item by considering expiration factor and lead time crashing cost results in a decrease in total costs amounted to 71.5% and multi item results in a decrease in total costs amounted to 71.62%. Subsequently, wasted expired materials, with the proposed models have been successfully decreased to 95%.

  15. SLIT ADJUSTMENT CLAMP

    DOEpatents

    McKenzie, K.R.

    1959-07-01

    An electrode support which permits accurate alignment and adjustment of the electrode in a plurality of planes and about a plurality of axes in a calutron is described. The support will align the slits in the electrode with the slits of an ionizing chamber so as to provide for the egress of ions. The support comprises an insulator, a leveling plate carried by the insulator and having diametrically opposed attaching screws screwed to the plate and the insulator and diametrically opposed adjusting screws for bearing against the insulator, and an electrode associated with the plate for adjustment therewith.

  16. Adjustable speed drives: Applications and R&D needs

    SciTech Connect

    Stefanovic, V.R.

    1995-09-01

    The largest opportunity for the growth of adjustable speed drives (ASDs) during the next 5-6 years is in pump, fan and compressor (PFC) applications where a constant, fixed speed operation is converted to adjustable speed in order to realize energy savings. Inverter supplied induction motors are and will continue to be predominately used in these applications. Over the long term (10-15 years), the greatest ASD growth is expected in large volume consumer applications: first in hybrid electric vehicles (EVs) and in residential heating, ventilation and air-conditioning (HVAC). Both induction and a variety of AC Permanent Magnet motors are expected to be the dominant technology in this new field. The traditional ASD applications in industries which require adjustable speed (such as machine tools, robotics, steel rolling, extruders, paper mill finishing lines, etc.) offer a relatively limited potential for above average ASD growth since most of these applications have already converted to electronic speed control. As a result, ASD growth in this sector will essentially track the growth of the corresponding industries. If realized, both short and long term ASD growth opportunities will result in significant advancements of ASD technology, which will then substantially affect all other, more fragmented, ASD applications. In fact, any single large volume ASD application will serve as a catalyst for improving ASD characteristics in all other ASD applications with the same voltage rating. ASD cost and reliability (defined in the context of application compatibility) are the two most important factors which will determine whether the ASD growth opportunities are realized. Conversely, any technological improvement which carries a cost increase will be restricted to niche applications, at best. Consequently, future R & D efforts should be directed to secure reduction in ASD cost and improvement in ASD reliability. A specific action plan is outlined in this report.

  17. Enhanced ABC costing for hospitals: directed expense costing.

    PubMed

    Ryan, J

    1997-10-01

    Space limitations do not allow a complete discussion of all the topics and many of the obvious questions that the preceding brief introduction to directed expense costing probably raised in the reader's mind. These include how errors in accounting practices like posting expenses to the wrong period are handled; and how the system automatically adjusts costs for expenses benefiting several periods but posted to the acquisition month. As was mentioned above, underlying this overtly simple costing method are a number of sophisticated and sometimes complex processes that are hidden from the normal user and designed to automatically protect the integrity and accuracy of the costing process. From a user's viewpoint, the system is straightforward, understandable, and easy to use and audit. From a software development perspective, it is not quite that effortless. By using a system that is understood by all users at all levels, these users can now communicate with each other in a new and effective way. This new communication channel only occurs after each user is satisfied as to the overall costing quality achieved by the process. However, not all managers or physicians are always happy that the institution is using this "understandable" cost accounting system. During one of the weekly meetings of a hospital's administrative council, complaints from several powerful department heads concerning the impact that the use of cost data was having on them were brought up for discussion. In defending the continued use of the system, one vice president stated to the group that cost accounting does not get any easier than this, or any less expensive, or any more accurate. The directed expense process works and works very well. Our department heads and physicians will have to come to grips with the accountably it provides us to assess their value to the hospital. PMID:10173184

  18. Enhanced ABC costing for hospitals: directed expense costing.

    PubMed

    Ryan, J

    1997-10-01

    Space limitations do not allow a complete discussion of all the topics and many of the obvious questions that the preceding brief introduction to directed expense costing probably raised in the reader's mind. These include how errors in accounting practices like posting expenses to the wrong period are handled; and how the system automatically adjusts costs for expenses benefiting several periods but posted to the acquisition month. As was mentioned above, underlying this overtly simple costing method are a number of sophisticated and sometimes complex processes that are hidden from the normal user and designed to automatically protect the integrity and accuracy of the costing process. From a user's viewpoint, the system is straightforward, understandable, and easy to use and audit. From a software development perspective, it is not quite that effortless. By using a system that is understood by all users at all levels, these users can now communicate with each other in a new and effective way. This new communication channel only occurs after each user is satisfied as to the overall costing quality achieved by the process. However, not all managers or physicians are always happy that the institution is using this "understandable" cost accounting system. During one of the weekly meetings of a hospital's administrative council, complaints from several powerful department heads concerning the impact that the use of cost data was having on them were brought up for discussion. In defending the continued use of the system, one vice president stated to the group that cost accounting does not get any easier than this, or any less expensive, or any more accurate. The directed expense process works and works very well. Our department heads and physicians will have to come to grips with the accountably it provides us to assess their value to the hospital.

  19. Remotely Adjustable Hydraulic Pump

    NASA Technical Reports Server (NTRS)

    Kouns, H. H.; Gardner, L. D.

    1987-01-01

    Outlet pressure adjusted to match varying loads. Electrohydraulic servo has positioned sleeve in leftmost position, adjusting outlet pressure to maximum value. Sleeve in equilibrium position, with control land covering control port. For lowest pressure setting, sleeve shifted toward right by increased pressure on sleeve shoulder from servovalve. Pump used in aircraft and robots, where hydraulic actuators repeatedly turned on and off, changing pump load frequently and over wide range.

  20. Weighted triangulation adjustment

    USGS Publications Warehouse

    Anderson, Walter L.

    1969-01-01

    The variation of coordinates method is employed to perform a weighted least squares adjustment of horizontal survey networks. Geodetic coordinates are required for each fixed and adjustable station. A preliminary inverse geodetic position computation is made for each observed line. Weights associated with each observed equation for direction, azimuth, and distance are applied in the formation of the normal equations in-the least squares adjustment. The number of normal equations that may be solved is twice the number of new stations and less than 150. When the normal equations are solved, shifts are produced at adjustable stations. Previously computed correction factors are applied to the shifts and a most probable geodetic position is found for each adjustable station. Pinal azimuths and distances are computed. These may be written onto magnetic tape for subsequent computation of state plane or grid coordinates. Input consists of punch cards containing project identification, program options, and position and observation information. Results listed include preliminary and final positions, residuals, observation equations, solution of the normal equations showing magnitudes of shifts, and a plot of each adjusted and fixed station. During processing, data sets containing irrecoverable errors are rejected and the type of error is listed. The computer resumes processing of additional data sets.. Other conditions cause warning-errors to be issued, and processing continues with the current data set.

  1. Increasing revenue through fee review and adjustment.

    PubMed

    Wild, J; Cimerola, J

    1996-08-01

    Medical group practices are under increasing pressure to deliver care more cost-efficiently. To remain competitive, practices must find ways to increase their fee-for-service revenue. One way for medical group practices to increase revenue is to review fees in accordance with industry standards and to adjust them, as needed.

  2. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Subject to lower ceilings prescribed by local law, the Cost of Money to the Small Business must not exceed... section applies to all Loans and Debt Securities. As required by § 107.800(b), you must include as Debt... of Money ceiling of 19 percent for a Loan and 14 percent for a Debt Security. To determine...

  3. Cost and cost-effectiveness of multidrug-resistant tuberculosis treatment in Estonia and Russia.

    PubMed

    Floyd, Katherine; Hutubessy, Raymond; Kliiman, Kai; Centis, Rosella; Khurieva, Nina; Jakobowiak, Wieslaw; Danilovits, Manfred; Peremitin, Genadi; Keshavjee, Salmaan; Migliori, Giovanni Battista

    2012-07-01

    Evidence on the cost and cost-effectiveness of treatment of multidrug-resistant tuberculosis (MDR-TB) is limited, and no published data are available from former Soviet Union countries, where rates of MDR-TB are highest globally. We evaluated the cost and cost-effectiveness of MDR-TB treatment in Estonia and Russia (Tomsk Oblast), comparing cohorts enrolled on treatment according to World Health Organization (WHO) guidelines in 2001 and 2002 with cohorts treated in previous years. Costs were assessed from a health system perspective in 2003 US$; effects were measured as cures, deaths averted and disability-adjusted life-years (DALYs) averted. Cure rates when WHO guidelines were followed were 61% (90 out of 149) in Estonia and 76% (76 out of 100) in Tomsk Oblast, with a cost per patient treated of US$8,974 and US$10,088, respectively. Before WHO guidelines were followed, cure rates were 52% in Estonia and 15% in Tomsk Oblast; the cost per patient treated was US$4,729 and US$2,282, respectively. Drugs and hospitalisation accounted for 69-90% of total costs. The cost per DALY averted by treatment following WHO guidelines was US$579 (range US$297-US$902) in Estonia and US$429 (range US$302-US$546) in Tomsk Oblast. Treatment of patients with MDR-TB can be cost-effective, but requires substantial additional investment in tuberculosis control in priority countries. PMID:22362862

  4. Antimicrobial stewardship programs - cost-minimizing or cost-effective?

    PubMed

    You, Joyce

    2015-02-01

    Antimicrobial stewardship programs (ASPs) are aimed to improve patient care and health care outcomes. It is encouraging to find ASP interventions to be cost-saving in many cost-minimization analyses in literature. Nevertheless, the cost-effectiveness of ASP interventions, measured in cost per quality-adjusted life-years, is less well-established. This Editorial aims to explore the barriers in assessing clinical effectiveness of ASPs and provide suggestions to conduct cost-effectiveness analysis of ASPs. PMID:25331093

  5. Simple, Internally Adjustable Valve

    NASA Technical Reports Server (NTRS)

    Burley, Richard K.

    1990-01-01

    Valve containing simple in-line, adjustable, flow-control orifice made from ordinary plumbing fitting and two allen setscrews. Construction of valve requires only simple drilling, tapping, and grinding. Orifice installed in existing fitting, avoiding changes in rest of plumbing.

  6. Self Adjusting Sunglasses

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Corning Glass Works' Serengeti Driver sunglasses are unique in that their lenses self-adjust and filter light while suppressing glare. They eliminate more than 99% of the ultraviolet rays in sunlight. The frames are based on the NASA Anthropometric Source Book.

  7. Rural to Urban Adjustment

    ERIC Educational Resources Information Center

    Abramson, Jane A.

    Personal interviews with 100 former farm operators living in Saskatoon, Saskatchewan, were conducted in an attempt to understand the nature of the adjustment process caused by migration from rural to urban surroundings. Requirements for inclusion in the study were that respondents had owned or operated a farm for at least 3 years, had left their…

  8. Self adjusting inclinometer

    DOEpatents

    Hunter, Steven L.

    2002-01-01

    An inclinometer utilizing synchronous demodulation for high resolution and electronic offset adjustment provides a wide dynamic range without any moving components. A device encompassing a tiltmeter and accompanying electronic circuitry provides quasi-leveled tilt sensors that detect highly resolved tilt change without signal saturation.

  9. A demand-side view of risk adjustment.

    PubMed

    Feldman, R; Dowd, B E; Maciejewski, M

    2001-01-01

    This paper analyzes the efficient allocation of consumers to health plans. Specifically, we address the question of why employers that offer multiple health plans often make larger contributions to the premiums of the high-cost plans. Our perspective is that the subsidy for high-cost plans represents a form of demand-side risk adjustment that improves efficiency. Without such subsidies (and in the absence of formal risk adjustment), too few employees would choose the high-cost plans preferred by high-risk workers. We test the theory by estimating a model of the employer premium subsidy, using data from a survey of large public employers in 1994. Our empirical analysis shows that employers are more likely to subsidize high-cost plans when the benefits of risk adjustment are greater. The findings suggest that the premium subsidy can accomplish some of the benefits of formal risk adjustment.

  10. 10 CFR 436.22 - Adjusted internal rate of return.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Methodology and Procedures for Life Cycle Cost Analyses § 436.22 Adjusted internal rate of return. The adjusted internal rate of return is the overall rate of return on an energy or water conservation measure... yearly net savings in energy or water and non-fuel or non-water operation and maintenance...

  11. 10 CFR 436.22 - Adjusted internal rate of return.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Methodology and Procedures for Life Cycle Cost Analyses § 436.22 Adjusted internal rate of return. The adjusted internal rate of return is the overall rate of return on an energy or water conservation measure... yearly net savings in energy or water and non-fuel or non-water operation and maintenance...

  12. 45 CFR 153.330 - State alternate risk adjustment methodology.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT State Standards Related to the Risk Adjustment Program § 153.330 State alternate risk... methodology: (i) Accurately explains the variation in health care costs of a given population; (ii) Links...

  13. 45 CFR 153.330 - State alternate risk adjustment methodology.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT State Standards Related to the Risk Adjustment Program § 153.330 State alternate risk... methodology: (i) Accurately explains the variation in health care costs of a given population; (ii) Links...

  14. 10 CFR 436.22 - Adjusted internal rate of return.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Adjusted internal rate of return. 436.22 Section 436.22 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.22 Adjusted internal rate of return....

  15. 42 CFR 413.232 - Low-volume adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.232 Low-volume adjustment. (a) CMS adjusts the base rate for low-volume ESRD facilities, as defined in paragraph (b) of this section. (b) Definition of low-volume facility. A low-volume facility is an ESRD facility that: (1) Furnished less than...

  16. 42 CFR 413.232 - Low-volume adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.232 Low-volume adjustment. (a) CMS adjusts the base rate for low-volume ESRD facilities, as defined in paragraph (b) of this section. (b) Definition of low-volume facility. A low-volume facility is an ESRD facility that: (1) Furnished less than...

  17. 42 CFR 413.232 - Low-volume adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Disease (ESRD) Services and Organ Procurement Costs § 413.232 Low-volume adjustment. (a) CMS adjusts the base rate for low-volume ESRD facilities, as defined in paragraph (b) of this section. (b) Definition of low-volume facility. A low-volume facility is an ESRD facility that: (1) Furnished less than...

  18. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND... Department shall adjust annually, using the CPI-U as defined in this part, amounts paid to an active...

  19. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND... Department shall adjust annually, using the CPI-U as defined in this part, amounts paid to an active...

  20. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND... Department shall adjust annually, using the CPI-U as defined in this part, amounts paid to an active...

  1. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND... Department shall adjust annually, using the CPI-U as defined in this part, amounts paid to an active...

  2. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND... Department shall adjust annually, using the CPI-U as defined in this part, amounts paid to an active...

  3. Role of Osmotic Adjustment in Plant Productivity

    SciTech Connect

    Gebre, G.M.

    2001-01-11

    Successful implementation of short rotation woody crops requires that the selected species and clones be productive, drought tolerant, and pest resistant. Since water is one of the major limiting factors in poplar (Populus sp.) growth, there is little debate for the need of drought tolerant clones, except on the wettest of sites (e.g., lower Columbia River delta). Whether drought tolerance is compatible with productivity remains a debatable issue. Among the many mechanisms of drought tolerance, dehydration postponement involves the maintenance of high leaf water potential due to, for example, an adequate root system. This trait is compatible with productivity, but requires available soil moisture. When the plant leaf water potential and soil water content decline, the plant must be able to survive drought through dehydration tolerance mechanisms, such as low osmotic potential or osmotic adjustment. Osmotic adjustment and low osmotic potential are considered compatible with growth and yield because they aid in the maintenance of leaf turgor. However, it has been shown that turgor alone does not regulate cell expansion or stomatal conductance and, therefore, the role of osmotic adjustment is debated. Despite this finding, osmotic adjustment has been correlated with grain yield in agronomic crop species, and gene markers responsible for osmotic adjustment are being investigated to improve drought tolerance in productive progenies. Although osmotic adjustment and low osmotic potentials have been investigated in several forest tree species, few studies have investigated the relationship between osmotic adjustment and growth. Most of these studies have been limited to greenhouse or container-grown plants. Osmotic adjustment and rapid growth have been specifically associated in Populus and black spruce (Picea mariuna (Mill.) B.S.P.) progenies. We tested whether these relationships held under field conditions using several poplar clones. In a study of two hybrid poplar

  4. Cost Analysis of MRI Services in Iran: An Application of Activity Based Costing Technique

    PubMed Central

    Bayati, Mohsen; Mahboub Ahari, Alireza; Badakhshan, Abbas; Gholipour, Mahin; Joulaei, Hassan

    2015-01-01

    Background: Considerable development of MRI technology in diagnostic imaging, high cost of MRI technology and controversial issues concerning official charges (tariffs) have been the main motivations to define and implement this study. Objectives: The present study aimed to calculate the unit-cost of MRI services using activity-based costing (ABC) as a modern cost accounting system and to fairly compare calculated unit-costs with official charges (tariffs). Materials and Methods: We included both direct and indirect costs of MRI services delivered in fiscal year 2011 in Shiraz Shahid Faghihi hospital. Direct allocation method was used for distribution of overhead costs. We used micro-costing approach to calculate unit-cost of all different MRI services. Clinical cost data were retrieved from the hospital registering system. Straight-line method was used for depreciation cost estimation. To cope with uncertainty and to increase the robustness of study results, unit costs of 33 MRI services was calculated in terms of two scenarios. Results: Total annual cost of MRI activity center (AC) was calculated at USD 400,746 and USD 532,104 based on first and second scenarios, respectively. Ten percent of the total cost was allocated from supportive departments. The annual variable costs of MRI center were calculated at USD 295,904. Capital costs measured at USD 104,842 and USD 236, 200 resulted from the first and second scenario, respectively. Existing tariffs for more than half of MRI services were above the calculated costs. Conclusion: As a public hospital, there are considerable limitations in both financial and administrative databases of Shahid Faghihi hospital. Labor cost has the greatest share of total annual cost of Shahid Faghihi hospital. The gap between unit costs and tariffs implies that the claim for extra budget from health providers may not be relevant for all services delivered by the studied MRI center. With some adjustments, ABC could be implemented in MRI

  5. Precision adjustable stage

    DOEpatents

    Cutburth, Ronald W.; Silva, Leonard L.

    1988-01-01

    An improved mounting stage of the type used for the detection of laser beams is disclosed. A stage center block is mounted on each of two opposite sides by a pair of spaced ball bearing tracks which provide stability as well as simplicity. The use of the spaced ball bearing pairs in conjunction with an adjustment screw which also provides support eliminates extraneous stabilization components and permits maximization of the area of the center block laser transmission hole.

  6. Adjustable vane windmills

    SciTech Connect

    Ducker, W.L.

    1982-09-14

    A system of rotatably and pivotally mounted radially extended bent supports for radially extending windmill rotor vanes in combination with axially movable radially extended control struts connected to the vanes with semi-automatic and automatic torque and other sensing and servo units provide automatic adjustment of the windmill vanes relative to their axes of rotation to produce mechanical output at constant torque or at constant speed or electrical quantities dependent thereon.

  7. Adjustable vane windmills

    SciTech Connect

    Ducker, W.L.

    1980-01-15

    A system of rotatably and pivotally mounted radially extended bent supports for radially extending windmill rotor vanes in combination with axially movable radially extended control struts connected to the vanes with semi-automatic and automatic torque and other sensing and servo units provide automatic adjustment of the windmill vanes relative to their axes of rotation to produce mechanical output at constant torque or at constant speed or electrical quantities dependent thereon.

  8. Adjustable vane windmills

    SciTech Connect

    Ducker, W.L.

    1982-09-07

    A system of rotatably and pivotally mounted radially extended bent supports for radially extending windmill rotor vanes in combination with axially movable radially extended control struts connected to the vanes with semi-automatic and automatic torque and other sensing and servo units provide automatic adjustment of the windmill vanes relative to their axes of rotation to produce mechanical output at constant torque or at constant speed or electrical quantities dependent thereon.

  9. Adjustable Autonomy Testbed

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Schrenkenghost, Debra K.

    2001-01-01

    The Adjustable Autonomy Testbed (AAT) is a simulation-based testbed located in the Intelligent Systems Laboratory in the Automation, Robotics and Simulation Division at NASA Johnson Space Center. The purpose of the testbed is to support evaluation and validation of prototypes of adjustable autonomous agent software for control and fault management for complex systems. The AA T project has developed prototype adjustable autonomous agent software and human interfaces for cooperative fault management. This software builds on current autonomous agent technology by altering the architecture, components and interfaces for effective teamwork between autonomous systems and human experts. Autonomous agents include a planner, flexible executive, low level control and deductive model-based fault isolation. Adjustable autonomy is intended to increase the flexibility and effectiveness of fault management with an autonomous system. The test domain for this work is control of advanced life support systems for habitats for planetary exploration. The CONFIG hybrid discrete event simulation environment provides flexible and dynamically reconfigurable models of the behavior of components and fluids in the life support systems. Both discrete event and continuous (discrete time) simulation are supported, and flows and pressures are computed globally. This provides fast dynamic simulations of interacting hardware systems in closed loops that can be reconfigured during operations scenarios, producing complex cascading effects of operations and failures. Current object-oriented model libraries support modeling of fluid systems, and models have been developed of physico-chemical and biological subsystems for processing advanced life support gases. In FY01, water recovery system models will be developed.

  10. 45 CFR 1170.44 - Academic adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE... ASSISTED PROGRAMS OR ACTIVITIES Postsecondary Education § 1170.44 Academic adjustments. (a) Academic... limiting the participation of handicapped students in the recipient's education program or activity....

  11. 45 CFR 1170.44 - Academic adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE... ASSISTED PROGRAMS OR ACTIVITIES Postsecondary Education § 1170.44 Academic adjustments. (a) Academic... limiting the participation of handicapped students in the recipient's education program or activity....

  12. 45 CFR 1170.44 - Academic adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE... ASSISTED PROGRAMS OR ACTIVITIES Postsecondary Education § 1170.44 Academic adjustments. (a) Academic... limiting the participation of handicapped students in the recipient's education program or activity....

  13. Call Number Adjustment: The Effects on Browsability if No Adjustment Is Made.

    ERIC Educational Resources Information Center

    Rodman, Ruey L.

    In these times of tight budgets, libraries are seeking ways to cut costs, and one area being examined is book processing. This study assesses the impact on the organization of a library collection if the call number is not changed to fit into the shelf list sequence. The research questions examined are: "Is it necessary to adjust the book number…

  14. Nonlinear dynamics in a heterogeneous duopoly game with adjusting players and diseconomies of scale

    NASA Astrophysics Data System (ADS)

    Dubiel-Teleszynski, Tomasz

    2011-01-01

    A repeated, discrete time, heterogeneous Cournot duopoly game with bounded rational and adaptive players adjusting the quantities of production is subject of investigation. Linear inverse demand function and quadratic cost functions reflecting decreasing returns to scale are assumed. The game is modeled with a system of two difference equations. Evolution of outputs over time is obtained by iteration of a two dimensional nonlinear map. Existing equilibria and their stability are analyzed. In face of diseconomies of scale, bounded rational and adaptive duopolists are shown to experience a decrease in the latitude of their output adjustment decisions with respect to the market stability compared to constant returns to scale and ceteris paribus. Chaotic dynamics is confirmed to depend mainly on the adjustment behavior of the bounded rational player, who if overshoots leaves the adaptive player with limited opportunities to stabilize the market again, hence industries facing diseconomies of scale are found to be less stable than those with constant marginal costs. Complexity of the dynamical system is examined by means of numerical simulations, where the paper extends the results of other authors who considered analogous games assuming linear cost functions. Intermittent transition to chaos and attractor merging crisis are shown among others.

  15. Risk adjustment for high utilizers of public mental health care.

    PubMed

    Kapur, Kanika; Young, Alexander S.; Murata, Dennis

    2000-09-01

    BACKGROUND: Publicly funded mental health systems are increasingly implementing managed care systems, such as capitation, to control costs. Capitated contracts may increase the risk for disenrollment or adverse outcomes among high cost clients with severe mental illness. Risk-adjusted payments to providers are likely to reduce providers' incentives to avoid or under-treat these people. However, most research has focused on Medicare and private populations, and risk adjustment for individuals who are publicly funded and severely mentally ill has received far less attention. AIMS OF THE STUDY: Risk adjustment models for this population can be used to improve contracting for mental health care. Our objective is to develop risk adjustment models for individuals with severe mental illness and assess their performance in predicting future costs. We apply the risk adjustment model to predict costs for the first year of a pilot capitation program for the severely mentally ill that was not risk adjusted. We assess whether risk adjustment could have reduced disenrollment from this program. METHODS: This analysis uses longitudinal administrative data from the County of Los Angeles Department of Mental Health for the fiscal years 1991 to 1994. The sample consists of 1956 clients who have high costs and are severely mentally ill. We estimate several modified two part models of 1993 cost that use 1992 client-based variables such as demographics, living conditions, diagnoses and mental health costs (for 1992 and 1991) to explain the variation in mental health and substance abuse costs. RESULTS: We find that the model that incorporates demographic characteristics, diagnostic information and cost data from two previous years explains about 16 percent of the in-sample variation and 10 percent of the out-of-sample variation in costs. A model that excludes prior cost covariates explains only 5 percent of the variation in costs. Despite the relatively low predictive power, we find some

  16. Dried tube specimens: a simple and cost-effective method for preparation of HIV proficiency testing panels and quality control materials for use in resource-limited settings.

    PubMed

    Parekh, Bharat S; Anyanwu, Juliana; Patel, Hetal; Downer, Marie; Kalou, Mireille; Gichimu, Catherine; Keipkerich, Bera Steven; Clement, Nelly; Omondi, Michael; Mayer, Oren; Ou, Chin-Yih; Nkengasong, John N

    2010-02-01

    HIV testing has rapidly expanded worldwide, but proficiency testing (PT) programs to monitor and improve the quality of testing are often lacking in resource-limited settings (RLS). Traditional PT programs and quality control reagents use serum or plasma specimens requiring stringent conditions for storage and transportation. A novel, simple and easy to use approach, based on dried tube specimens (DTS), was developed that can help monitor the quality of HIV antibody testing in RLS. DTS were prepared by drying 20 microl of specimen overnight at room temperature. The addition of a green dye (0.1%) made the DTS pellets visible without affecting the test results. Before testing, the DTS were rehydrated with 200 microl of PBS-Tween buffer. A panel of 303 DTS samples (135 HIV positive and 168 HIV negative) was evaluated with two rapid tests. Sensitivity and specificity with the Determine HIV-1/2 test were 99.3% and 99.4%, respectively, and with OraQuick were 98.5% and 100%, respectively. Stability studies showed that HIV-specific antibodies in the DTS specimens were stable at 4 degrees C and 25 degrees C for 4 weeks, with only marginal decline at 37 degrees C and 45 degrees C over 4 weeks. The DTS-based PT program was piloted successfully in 24 testing sites in Kenya. Results demonstrate that the DTS is a simple to use, practical method to prepare and distribute PT panels and quality control specimens to monitor HIV testing practices in RLS. PMID:19878697

  17. Cost characteristics of hospitals.

    PubMed

    Smet, Mike

    2002-09-01

    Modern hospitals are complex multi-product organisations. The analysis of a hospital's production and/or cost structure should therefore use the appropriate techniques. Flexible functional forms based on the neo-classical theory of the firm seem to be most suitable. Using neo-classical cost functions implicitly assumes minimisation of (variable) costs given that input prices and outputs are exogenous. Local and global properties of flexible functional forms and short-run versus long-run equilibrium are further issues that require thorough investigation. In order to put the results based on econometric estimations of cost functions in the right perspective, it is important to keep these considerations in mind when using flexible functional forms. The more recent studies seem to agree that hospitals generally do not operate in their long-run equilibrium (they tend to over-invest in capital (capacity and equipment)) and that it is therefore appropriate to estimate a short-run variable cost function. However, few studies explicitly take into account the implicit assumptions and restrictions embedded in the models they use. An alternative method to explain differences in costs uses management accounting techniques to identify the cost drivers of overhead costs. Related issues such as cost-shifting and cost-adjusting behaviour of hospitals and the influence of market structure on competition, prices and costs are also discussed shortly. PMID:12220092

  18. Subsea adjustable choke valves

    SciTech Connect

    Cyvas, M.K. )

    1989-08-01

    With emphasis on deepwater wells and marginal offshore fields growing, the search for reliable subsea production systems has become a high priority. A reliable subsea adjustable choke is essential to the realization of such a system, and recent advances are producing the degree of reliability required. Technological developments have been primarily in (1) trim material (including polycrystalline diamond), (2) trim configuration, (3) computer programs for trim sizing, (4) component materials, and (5) diver/remote-operated-vehicle (ROV) interfaces. These five facets are overviewed and progress to date is reported. A 15- to 20-year service life for adjustable subsea chokes is now a reality. Another factor vital to efficient use of these technological developments is to involve the choke manufacturer and ROV/diver personnel in initial system conceptualization. In this manner, maximum benefit can be derived from the latest technology. Major areas of development still required and under way are listed, and the paper closes with a tabulation of successful subsea choke installations in recent years.

  19. 77 FR 60047 - Adjustment of Civil Monetary Penalties for Inflation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... most recent cost adjustment to each CMP in the Federal Register on January 4, 2005 (70 FR 297), and... compliance costs that might result from technological innovation or anticipated behavioral changes.'' We are..., and inconsequential to the industry and to the public.'' Utility Solid Waste Activities Group v....

  20. 42 CFR 412.322 - Indirect medical education adjustment factor.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES Prospective Payment System for Inpatient Hospital Capital Costs Basic Methodology for Determining the Federal Rate for Capital-Related Costs § 412.322 Indirect medical education adjustment factor. (a) Basic data....