Science.gov

Sample records for adjust cost limits

  1. 75 FR 33379 - Railroad Cost Recovery Procedures-Productivity Adjustment; Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment; Quarterly Rail... Railroads that the Board restate the previously published productivity adjustment for the 2003-2007 averaging period (2007 productivity adjustment) so that it tracks the 2007 productivity adjustment...

  2. Equity flotation cost adjustments in utilities' cost of service

    SciTech Connect

    Bierman, H. Jr.; Hass, J.E.

    1984-03-01

    Recovery of the unavoidable costs of issuing new shares of stock is generally agreed to be appropriate in determining utility revenue requirements. This article suggests that the methods by which that is usually accomplished are of questionable accuracy. The conventional practice of adjusting the allowed rate of return on common equity is examined, and an improved adjustment formulation is presented. Acknowledging that application of the formula remains subject to considerable error, however, the authors propose yet another solution. Capitalization of flotation costs as intangible assets is suggested as a way of more accurately factoring such expenses into tariff determinations. 6 references.

  3. 75 FR 16575 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board. ACTION: Adoption of a railroad cost recovery procedures productivity adjustment. SUMMARY... productivity adjustment, as measured by the average change in railroad productivity for the years 2004...

  4. 76 FR 16037 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the second quarter 2011 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  5. 76 FR 59483 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2011 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  6. 77 FR 58910 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2012 rail cost adjustment factor (RCAF) and cost index filed by the Association of American Railroads....

  7. 77 FR 37958 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the third quarter 2012 rail cost adjustment factor (RCAF) and cost index filed by the Association of...

  8. 77 FR 17121 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, Department of Transportation. ACTION: Approval of rail cost adjustment factor. ] SUMMARY: The Board has approved the second quarter 2012 rail cost adjustment factor (RCAF) and cost index filed by the...

  9. 78 FR 17764 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the second quarter 2013 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  10. 76 FR 37191 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the third quarter 2011 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  11. 75 FR 80895 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the first quarter 2011 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  12. 78 FR 37660 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board approves the third quarter 2013 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of American...

  13. 75 FR 58019 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the fourth quarter 2010 Rail Cost Adjustment Factor (RCAF) and cost index filed by the Association of...

  14. 75 FR 35877 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... TRANSPORTATION Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the third quarter 2010 rail cost adjustment factor (RCAF) and cost index filed by the Association of...

  15. 76 FR 80448 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ...-No. 5) (2012-1)] Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the first quarter 2012 rail cost adjustment factor (RCAF) and cost index filed by the Association of American Railroads. The first...

  16. 75 FR 5170 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board, DOT. ACTION: Proposed Railroad Cost Recovery Procedures Productivity Adjustment....

  17. 78 FR 10262 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board, DOT. ACTION: Proposed railroad cost recovery procedures productivity adjustment. SUMMARY... of average change in railroad productivity for the 2007-2011 (5-year) averaging period....

  18. 77 FR 76169 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... Surface Transportation Board Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the AAR's proposed rebasing calculations and the rebased first quarter 2013 rail cost adjustment factor (RCAF)...

  19. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... current costs. CMS adjusts current and past period data to arrive at estimated costs for the prospective... 42 Public Health 2 2010-10-01 2010-10-01 false Limitations on payable costs. 413.30 Section 413.30... PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE...

  20. 5 CFR 837.505 - Cost-of-living adjustments on Member annuities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Member annuities under CSRS. A member annuity benefit that is recomputed under section 8344(d)(1) of... section 8344(d)(1). (b) Limitations on cost-of-living adjustments on recomputed Member annuities under CSRS. For purposes of determining limitations on cost-of-living adjustments under section 8340(g)...

  1. 78 FR 59093 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... quarter. In Railroad Cost Recovery Procedures--Productivity Adjustment, 5 I.C.C. 2d 434 (1989), aff'd sub... require the adjustment of the quarterly index for a measure of productivity. The provisions of 49 U.S.C... a productivity-adjusted RCAF. In Productivity Adjustment--Implementation, 1 S.T.B. 739 (1996),...

  2. 45 CFR 149.115 - Cost threshold and cost limit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Cost threshold and cost limit. 149.115 Section 149... REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Reinsurance Amounts § 149.115 Cost threshold and cost limit. The following cost threshold and cost limits apply individually, to each early retiree as...

  3. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not exceed ten percent (10%) of the respective...

  4. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not...

  5. 77 FR 7237 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board. ACTION: Proposed railroad cost recovery procedures productivity adjustment. SUMMARY: In a... change in railroad productivity for the 2006-2010 (5-year) averaging period. This represents a...

  6. 5 CFR 838.1017 - Cost-of-living adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Cost-of-living adjustments. 838.1017 Section 838.1017 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... Retirement Benefits § 838.1017 Cost-of-living adjustments. In cases where the court order apportions...

  7. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... adjustments or modifications that result in a change to the performance costs of the cooperative agreement... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Adjustments to performance costs. 1274.801 Section 1274.801 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION...

  8. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... adjustments or modifications that result in a change to the performance costs of the cooperative agreement... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Adjustments to performance costs. 1274.801 Section 1274.801 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION...

  9. 14 CFR § 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Adjustments to performance costs. § 1274... COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Post-Award/Administrative Requirements § 1274.801 Adjustments to performance costs. In order to accomplish program objectives, there may be occasions where...

  10. 76 FR 59058 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Bureau of Land Management 43 CFR Part 3000 RIN 1004-AE22 Minerals Management: Adjustment of Cost Recovery... Management Act of 1976 (FLPMA), 43 U.S.C. 1734. In 2005, the BLM published a final cost recovery rule (70 FR... comment period on the original cost recovery rule, and this new rule simply administers the procedure...

  11. 20 CFR 631.62 - Cost limitations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Cost limitations. 631.62 Section 631.62... Reserve Account Funds § 631.62 Cost limitations. The expenditure of funds provided to grantees under this subpart shall be consistent with the cost limitations specified in the grant. Applicants for grants...

  12. 7 CFR 701.117 - Average adjusted gross income limitation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Average adjusted gross income limitation. 701.117 Section 701.117 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY... Conservation Program § 701.117 Average adjusted gross income limitation. To be eligible for payments...

  13. Adjusting Wages to Living Costs: A Historical Note

    ERIC Educational Resources Information Center

    Lowenstern, Henry

    1974-01-01

    The significant historical developments of the cost of living wage adjustments are summarized. Since the concept of cost of living took effect in 1919, developments that are noted are: World War II, the GM contract 1948, the GM Contract 1950, and the impact of the agreements. (DS)

  14. 76 FR 74806 - Adjustment of the Amount of an Administrative Costs Assessment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... Bureau of Reclamation Adjustment of the Amount of an Administrative Costs Assessment AGENCY: Bureau of... decreasing the amount of the administrative costs assessment set forth in the Acreage Limitation Rules and Regulations (Regulations), 43 CFR part 426. Based on our latest required review, the current...

  15. 77 FR 55420 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ... Bureau of Land Management 43 CFR Part 3000 RIN 1004-AE29 Minerals Management: Adjustment of Cost Recovery Fees AGENCY: Bureau of Land Management, Interior. ACTION: Final rule. SUMMARY: This final rule amends the Bureau of Land Management (BLM) mineral resources regulations to update some fees that cover...

  16. Adjustment of Design Limited Imperfections for Transportation Vehicles

    NASA Astrophysics Data System (ADS)

    Voges-Schwieger, Kathrin; Hübner, Sven; Behrens, Bernd-Arno

    2011-05-01

    The realization of light weight-construction without loss of passive safety in transportation vehicles is a big challenge for the next years. Considering the requirements on an automobile from consumer view a modern car should combine a high quality of comfort and standard with low operating expenses and a high safety standard. The use of lightweight design enables reductions in fuel consumption and CO2 emissions which are leading to a decrease of operating costs. The increase in passive safety is mainly characterized by an increase in strength and weight due to a concerted material selection, an enhancement of sheet metal thickness and additional compensating elements, e.g. patches. Especially for limited imperfections like cataphoretic drain holes or accesses for joining operations the strength adjustment without additional compensating elements and increasing weight possesses very much potential. The presented research investigate the possibility to reinforce local imperfections considering the material TRIP780 by combining different approaches on light-weight design. The reinforcements are realized by additional forming elements and enhance the moment of inertia. Different investigations were carried out to assess the placement and arrangement of the reinforcements in the deep drawing parts

  17. 45 CFR 149.115 - Cost threshold and cost limit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Cost threshold and cost limit. 149.115 Section 149.115 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS... percentage increase in the Medical Care Component of the Consumer Price Index for all urban...

  18. 45 CFR 149.115 - Cost threshold and cost limit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Cost threshold and cost limit. 149.115 Section 149.115 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS... percentage increase in the Medical Care Component of the Consumer Price Index for all urban...

  19. 76 FR 6148 - Notice of Adjustment of Statewide Per Capita Indicator for Recommending a Cost Share Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... Adjustment of Statewide Per Capita Indicator for Recommending a Cost Share Adjustment AGENCY: Federal... indicator for recommending cost share adjustments for major disasters declared on or after January 1, 2011... INFORMATION: Pursuant to 44 CFR 206.47, the statewide per capita indicator that is used to recommend...

  20. 75 FR 8353 - Price Index Adjustments for Expenditure Limitations and Lobbyist Bundling Disclosure Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Price Index Adjustments for Expenditure Limitations and Lobbyist Bundling Disclosure Threshold AGENCY: Federal Election Commission. ACTION: Notice of adjustments to expenditure limitations and lobbyist... Commission'') is adjusting certain expenditure limitations and the lobbyist bundling disclosure threshold...

  1. 77 FR 5262 - Notice of Adjustment of Statewide Per Capita Indicator for Recommending a Cost Share Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... SECURITY Federal Emergency Management Agency Notice of Adjustment of Statewide Per Capita Indicator for...: FEMA gives notice that the statewide per capita indicator for recommending cost share adjustments for... indicator that is used to recommend an increase of the Federal cost share from seventy-five percent (75%)...

  2. 78 FR 9935 - Notice of Adjustment of Statewide Per Capita Indicator for Recommending a Cost Share Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... SECURITY Federal Emergency Management Agency Notice of Adjustment of Statewide Per Capita Indicator for...: FEMA gives notice that the statewide per capita indicator for recommending cost share adjustments for... indicator that is used to recommend an increase of the Federal cost share from seventy-five percent (75%)...

  3. Limitations of quantitative research in the study of structural adjustment.

    PubMed

    Lundy, P

    1996-02-01

    Sociologists and, more recently, critical medical anthropologists have been arguing for a refocusing of the analysis of health and health care towards a perspective which considers the broader global political economy. In the context of the debt crisis and IMF/World Bank-inspired structural adjustment policies, the political economy theoretical perspective is becoming even more relevant in the analysis of health underdevelopment in many 'Third World' countries. This study focuses on the direct and indirect effects of the Jamaican debt crisis and structural adjustment programmes on health care services and health standards. In this paper it is argued that there are methodological problems using quantitative data when studying the effects of structural adjustment. In addition to providing a limited account of the effects, it is argued that the basic problem is a matter of the availability and reliability of the quantitative data in many 'Third World' countries. It is argued that some of these problems could be overcome by the application of qualitative micro-level analysis. This type of methodology is important to ascertain the effects of global processes at the grass roots level and to gain insights into what those working in the health sector are experiencing and what they perceive as the effects, if any, of structural adjustment policies. This has often been missing from the impersonal accounts offered by quantitative research on the subject to date.

  4. 78 FR 8530 - Price Index Adjustments for Contribution and Expenditure Limitations and Lobbyist Bundling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Price Index Adjustments for Contribution and Expenditure Limitations and Lobbyist Bundling Disclosure Threshold AGENCY: Federal Election Commission. ACTION: Notice of adjustments to contribution and expenditure...'' or ``the Commission'') is adjusting certain contribution and expenditure limitations and the...

  5. 76 FR 8368 - Price Index Adjustments for Contribution and Expenditure Limits and Lobbyist Bundling Disclosure...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Price Index Adjustments for Contribution and Expenditure Limits and Lobbyist Bundling Disclosure Threshold AGENCY: Federal Election Commission. ACTION: Notice of adjustments to contribution and expenditure...'' or ``the Commission'') is adjusting certain contribution and expenditure limits and the...

  6. Innovative Feed-In Tariff Designs that Limit Policy Costs

    SciTech Connect

    Kreycik, C.; Couture, T. D.; Cory, K. S.

    2011-06-01

    Feed-in tariffs (FITs) are the most prevalent renewable energy policy used globally to date, and there are many benefits to the certainty offered in the marketplace to reduce development risks and associated financing costs and to grow the renewable energy industry. However, concerns over escalating costs in jurisdictions with FIT policies have led to increased attention on cost control in renewable energy policy design. In recent years, policy mechanisms for containing FIT costs have become more refined, allowing policymakers to exert greater control on policy outcomes and on the resulting costs to ratepayers. As policymakers and regulators in the United States begin to explore the use of FITs, careful consideration must be given to the ways in which policy design can be used to balance the policies' advantages while bounding its costs. This report explores mechanisms that policymakers have implemented to limit FIT policy costs. If designed clearly and transparently, such mechanisms can align policymaker and market expectations for project deployment. Three different policy tools are evaluated: (1) caps, (2) payment level adjustment mechanisms, and (3) auction-based designs. The report employs case studies to explore the strengths and weaknesses of these three cost containment tools. These tools are then evaluated with a set of criteria including predictability for policymakers and the marketplace and the potential for unintended consequences.

  7. 10 CFR 950.26 - Adjustments to claim for payment of covered costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administration Process § 950.26 Adjustments to claim for payment of covered costs. (a) Aggregate amount of covered costs. The sponsor's aggregate amount of covered costs shall be reduced by any amounts that are... 10 Energy 4 2011-01-01 2011-01-01 false Adjustments to claim for payment of covered costs....

  8. 48 CFR 252.236-7006 - Cost limitation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Cost limitation. 252.236... Clauses 252.236-7006 Cost limitation. As prescribed in 236.570(b)(4), use the following provision: Cost Limitation (JAN 1997) (a) Certain items in this solicitation are subject to statutory cost limitations....

  9. 24 CFR 1000.320 - How is Formula Current Assisted Stock adjusted for local area costs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... § 1000.320 How is Formula Current Assisted Stock adjusted for local area costs? There are two adjustment... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false How is Formula Current Assisted Stock adjusted for local area costs? 1000.320 Section 1000.320 Housing and Urban Development...

  10. 32 CFR 269.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Cost of living adjustments of civil monetary... DEFENSE (CONTINUED) MISCELLANEOUS CIVIL MONETARY PENALTY INFLATION ADJUSTMENT § 269.4 Cost of living.... Maximum civil monetary penalties within the jurisdiction of the Department of Defense are adjusted...

  11. 5 CFR 838.622 - Cost-of-living and salary adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Cost-of-living and salary adjustments....622 Cost-of-living and salary adjustments. (a)(1) A court order that awards adjustments to a former... such as “salary adjustments” or “pay adjustments” occurring after the date of the decree...

  12. 5 CFR 838.622 - Cost-of-living and salary adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Cost-of-living and salary adjustments....622 Cost-of-living and salary adjustments. (a)(1) A court order that awards adjustments to a former... such as “salary adjustments” or “pay adjustments” occurring after the date of the decree...

  13. 5 CFR 838.622 - Cost-of-living and salary adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Cost-of-living and salary adjustments....622 Cost-of-living and salary adjustments. (a)(1) A court order that awards adjustments to a former... such as “salary adjustments” or “pay adjustments” occurring after the date of the decree...

  14. 5 CFR 838.622 - Cost-of-living and salary adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Cost-of-living and salary adjustments....622 Cost-of-living and salary adjustments. (a)(1) A court order that awards adjustments to a former... such as “salary adjustments” or “pay adjustments” occurring after the date of the decree...

  15. 5 CFR 838.622 - Cost-of-living and salary adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Cost-of-living and salary adjustments....622 Cost-of-living and salary adjustments. (a)(1) A court order that awards adjustments to a former... such as “salary adjustments” or “pay adjustments” occurring after the date of the decree...

  16. 14 CFR 13.305 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Inflation Adjustment § 13.305 Cost of living adjustments of civil monetary penalties. (a) Except for the... maximum civil monetary penalties set forth in paragraph (c) of this section, the inflation adjustment...) Inflation adjustment. Minimum and maximum civil monetary penalties within the jurisdiction of the FAA...

  17. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... NASA's initial cost share or funding levels, detailed cost analysis techniques may be applied, which... (cash and/or in-kind contributions) by NASA and the recipient beyond the initial agreement may be needed. There may also be occasions where actual costs of NASA and the recipient may be less than...

  18. 14 CFR 1274.801 - Adjustments to performance costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... NASA's initial cost share or funding levels, detailed cost analysis techniques may be applied, which... (cash and/or in-kind contributions) by NASA and the recipient beyond the initial agreement may be needed. There may also be occasions where actual costs of NASA and the recipient may be less than...

  19. 75 FR 17462 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... ``correct the productivity calculation for the period 2003-2007,'' and requests that the Board recalculate earlier RCAF (Adjusted) and RCAF-5 values that were determined with the 2003-2007 productivity...

  20. 37 CFR 381.10 - Cost of living adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... compositions in the repertory of SESAC, which shall adjust the royalty amounts established in a dollar amount... this section, or (2) Two percent (2%). (3) Such royalty rates shall be fixed at the nearest dollar....

  1. 32 CFR 269.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DEFENSE (CONTINUED) MISCELLANEOUS CIVIL MONETARY PENALTY INFLATION ADJUSTMENT § 269.4 Cost of living adjustments of civil monetary penalties. (a) The inflation adjustment under § 269.3 shall be determined by... monetary penalty pursuant to § 269.3 may not exceed 10 percent of such penalty. (d) Inflation...

  2. 10 CFR 950.26 - Adjustments to claim for payment of covered costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Adjustments to claim for payment of covered costs. 950.26 Section 950.26 Energy DEPARTMENT OF ENERGY STANDBY SUPPORT FOR CERTAIN NUCLEAR PLANT DELAYS Claims Administration Process § 950.26 Adjustments to claim for payment of covered costs. (a) Aggregate amount...

  3. 10 CFR 950.26 - Adjustments to claim for payment of covered costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Adjustments to claim for payment of covered costs. 950.26 Section 950.26 Energy DEPARTMENT OF ENERGY STANDBY SUPPORT FOR CERTAIN NUCLEAR PLANT DELAYS Claims Administration Process § 950.26 Adjustments to claim for payment of covered costs. (a) Aggregate amount...

  4. 10 CFR 950.26 - Adjustments to claim for payment of covered costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Adjustments to claim for payment of covered costs. 950.26 Section 950.26 Energy DEPARTMENT OF ENERGY STANDBY SUPPORT FOR CERTAIN NUCLEAR PLANT DELAYS Claims Administration Process § 950.26 Adjustments to claim for payment of covered costs. (a) Aggregate amount...

  5. 10 CFR 950.26 - Adjustments to claim for payment of covered costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Adjustments to claim for payment of covered costs. 950.26 Section 950.26 Energy DEPARTMENT OF ENERGY STANDBY SUPPORT FOR CERTAIN NUCLEAR PLANT DELAYS Claims Administration Process § 950.26 Adjustments to claim for payment of covered costs. (a) Aggregate amount...

  6. 78 FR 71501 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... Copyright Royalty Judges announce a cost of living adjustment (COLA) of 1% in the royalty rates satellite....gov . SUPPLEMENTARY INFORMATION: The satellite carrier compulsory license establishes a...

  7. 20 CFR 10.420 - How are cost-of-living adjustments applied?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of recurrence of disability, where the pay rate for compensation purposes is the pay rate at the time... effective date of that pay rate began more than one year prior to the date the cost-of living adjustment took effect. (d) In cases of death, entitlement to cost-of-living adjustments under 5 U.S.C....

  8. 20 CFR 10.420 - How are cost-of-living adjustments applied?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of recurrence of disability, where the pay rate for compensation purposes is the pay rate at the time... effective date of that pay rate began more than one year prior to the date the cost-of-living adjustment took effect. (d) In cases of death, entitlement to cost-of-living adjustments under 5 U.S.C....

  9. An Introduction to Cost-of-Living Adjustments in Public Retirement Plans: Details Matter

    ERIC Educational Resources Information Center

    Jennings, Penelope R.; Jennings, William P.; Phillips, G. Michael

    2016-01-01

    While financial planning students are expected to be able to understand client retirement plans, subtle differences in cost-of-living adjustments can have major impact on the success of client retirement plans. This teaching note compares the cost-of-living adjustments in the largest government sponsored retirement systems and a hypothetical…

  10. 20 CFR 631.62 - Cost limitations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... THE JOB TRAINING PARTNERSHIP ACT Federal Delivery of Dislocated Worker Services Through National... not adequately justify to the Grant Officer's satisfaction the costs to be incorporated into the...

  11. 20 CFR 631.62 - Cost limitations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... THE JOB TRAINING PARTNERSHIP ACT Federal Delivery of Dislocated Worker Services Through National... not adequately justify to the Grant Officer's satisfaction the costs to be incorporated into the...

  12. 33 CFR 138.240 - Procedure for calculating limit of liability adjustments for inflation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of liability adjustments for inflation. 138.240 Section 138.240 Navigation and Navigable Waters COAST... calculating limit of liability adjustments for inflation. (a) Formula for calculating a cumulative percent... every three years from the year the limits of liability were last adjusted for inflation, the...

  13. 33 CFR 138.240 - Procedure for calculating limit of liability adjustments for inflation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of liability adjustments for inflation. 138.240 Section 138.240 Navigation and Navigable Waters COAST... calculating limit of liability adjustments for inflation. (a) Formula for calculating a cumulative percent... every three years from the year the limits of liability were last adjusted for inflation, the...

  14. 44 CFR 206.47 - Cost-share adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... effective for disasters declared on or after May 21, 1999, $75 per capita of State population; (2) Effective... population; (3) Effective for disasters declared after January 1, 2001, $100 per capita of State population... of State population, adjusted annually for inflation using the Consumer Price Index for All...

  15. 44 CFR 206.47 - Cost-share adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... effective for disasters declared on or after May 21, 1999, $75 per capita of State population; (2) Effective... population; (3) Effective for disasters declared after January 1, 2001, $100 per capita of State population... of State population, adjusted annually for inflation using the Consumer Price Index for All...

  16. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., subject to validation by the intermediary, will estimate the current cost of the service to which a limit... when there is no second preceding period) exceed the current cost limits. (Data from the most recently... 42 Public Health 2 2010-10-01 2010-10-01 false Limitations on coverage of costs: Charges...

  17. Innovative Feed-In Tariff Designs that Limit Policy Costs

    SciTech Connect

    Kreycik, Claire; Couture, Toby D.; Cory, Karlynn S.

    2011-06-01

    Feed-in tariffs (FITs) are the most prevalent policy used globally to reduce development risks, cut financing costs, and grow the renewable energy industry. However, concerns over escalating costs in jurisdictions with FIT policies have led to increased attention on cost control. Using case studies and market-focused analysis, this report from the National Renewable Energy Laboratory (NREL) examines strengths and weaknesses of three cost-containment tools: (1) caps, (2) payment level adjustment mechanisms, and (3) auction-based designs. The report provides useful insights on containing costs for policymakers and regulators in the United States and other areas where FIT policies are in development.

  18. 78 FR 21712 - Compensation Cost-of-Living Adjustments for Service-Connected Benefits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... AFFAIRS Compensation Cost-of-Living Adjustments for Service-Connected Benefits AGENCY: Department of Veterans Affairs. ACTION: Notice. SUMMARY: As required by the Veterans' Compensation Cost-of-Living... Security Administration has announced that there will be a 1.7 percent cost-of-living increase in...

  19. 78 FR 49945 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... permit 25 \\6\\ 25 application--Alaska Renewal of exploration permit-- 25 \\7\\ 25 Alaska Geothermal (part... than $1, or to the nearest penny for values under $1. \\6\\ Section 365 of the Energy Policy Act of 2005...-dated the 2005 cost recovery rule and were not affected by the Energy Policy Act prohibition, the...

  20. 75 FR 55678 - Minerals Management: Adjustment of Cost Recovery Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... of Cost Recovery Fees AGENCY: Bureau of Land Management, Interior. ACTION: Final rule. SUMMARY: This final rule amends the Bureau of Land Management (BLM) mineral resources regulations to update some fees... filing fees for mineral-related documents. These updates include fees for actions such as lease...

  1. 37 CFR 253.10 - Cost of living adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Librarian of Congress shall publish in the Federal Register a notice of the change in the cost of living as determined by the Consumer Price Index (all consumers, all items) during the period from the most recent.... On each December 1 thereafter the Librarian of Congress shall publish a notice of the change in...

  2. 37 CFR 381.10 - Cost of living adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Royalty Judges shall publish in the Federal Register a notice of the change in the cost of living as determined by the Consumer Price Index (all consumers, all items) during the period from the most recent.... On each December 1 thereafter the Copyright Royalty Judges shall publish a notice of the change...

  3. 32 CFR 3.6 - Limitations on cost-sharing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... THAN CONTRACTS, GRANTS, OR COOPERATIVE AGREEMENTS FOR PROTOTYPE PROJECTS § 3.6 Limitations on cost... the performance of the OT agreement may not include costs that were incurred before the date on...

  4. 32 CFR 3.6 - Limitations on cost-sharing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THAN CONTRACTS, GRANTS, OR COOPERATIVE AGREEMENTS FOR PROTOTYPE PROJECTS § 3.6 Limitations on cost... the performance of the OT agreement may not include costs that were incurred before the date on...

  5. 78 FR 40665 - Cost Accounting Standards: CAS 413 Pension Adjustments for Extraordinary Events

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... Adjustments for Extraordinary Events AGENCY: Cost Accounting Standards Board, Office of Federal Procurement... Staff Discussion Paper (SDP) on CAS 413 Pension Adjustments for Extraordinary Events. This is the first... extraordinary events'' in the subject line. To ensure seating due to space constraints, potential attendees...

  6. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... section 415(b)(1)(A) dollar limit, and the defined benefit plan has a limitation year that runs from July... distribution that gives rise to a new annuity starting date. (5) Safe harbor for annual adjustments to... September 30 of the preceding calendar year over such index for the base period. Adjustment...

  7. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... section 415(b)(1)(A) dollar limit, and the defined benefit plan has a limitation year that runs from July... distribution that gives rise to a new annuity starting date. (5) Safe harbor for annual adjustments to... September 30 of the preceding calendar year over such index for the base period. Adjustment...

  8. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... section 415(b)(1)(A) dollar limit, and the defined benefit plan has a limitation year that runs from July... distribution that gives rise to a new annuity starting date. (5) Safe harbor for annual adjustments to... September 30 of the preceding calendar year over such index for the base period. Adjustment...

  9. Adjustable direct current and pulsed circuit fault current limiter

    DOEpatents

    Boenig, Heinrich J.; Schillig, Josef B.

    2003-09-23

    A fault current limiting system for direct current circuits and for pulsed power circuit. In the circuits, a current source biases a diode that is in series with the circuits' transmission line. If fault current in a circuit exceeds current from the current source biasing the diode open, the diode will cease conducting and route the fault current through the current source and an inductor. This limits the rate of rise and the peak value of the fault current.

  10. 77 FR 24456 - Retail Exemptions Adjusted Dollar Limitations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ...) is announcing the dollar limitations on the amount of meat and meat food products and poultry and poultry products that a retail store can sell to hotels, restaurants, and similar institutions without... $61,900 to $67,300 and for poultry products from $50,200 to $51,700. FSIS is changing the...

  11. 78 FR 23902 - Retail Exemptions Adjusted Dollar Limitations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ...) is announcing the dollar limitations on the amount of meat and meat food products, poultry, and poultry products that a retail store can sell to hotels, restaurants, and similar institutions without... $67,300 to $69,600 and for poultry products from $51,700 to $54,500. FSIS is changing the...

  12. 10 CFR 602.15 - Indirect cost limitations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Indirect cost limitations. 602.15 Section 602.15 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.15 Indirect cost limitations. Awards issued under this part for conferences...

  13. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Limitations on payable costs. 413.30 Section 413.30 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE... of needed health care services. CMS may establish estimated cost limits for direct or...

  14. 77 FR 9925 - Price Index Adjustments for Expenditure Limitations and Lobbyist Bundling Disclosure Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION...: Federal Election Commission. ACTION: Notice of adjustments to expenditure limitations and lobbyist bundling disclosure threshold. SUMMARY: As mandated by provisions of the Federal Election Campaign Act...

  15. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Limitations on payable costs. 413.30 Section 413.30 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE...

  16. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Limitations on payable costs. 413.30 Section 413.30 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE...

  17. 42 CFR 413.30 - Limitations on payable costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Limitations on payable costs. 413.30 Section 413.30 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT FOR END-STAGE RENAL DISEASE...

  18. 45 CFR 63.18 - Limitations on costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Limitations on costs. 63.18 Section 63.18 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GRANT PROGRAMS ADMINISTERED BY THE OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Financial Provisions § 63.18 Limitations...

  19. 45 CFR 63.18 - Limitations on costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Limitations on costs. 63.18 Section 63.18 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION GRANT PROGRAMS ADMINISTERED BY THE OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Financial Provisions § 63.18 Limitations...

  20. Social Security cost-of-living adjustments and the Consumer Price Index.

    PubMed

    Burdick, Clark; Fisher, Lynn

    2007-01-01

    base-period's living standard.... Unfortunately, because the cost of achieving a living standard cannot be observed directly, in operational terms, a COLI can only be approximated. Although the CPI cannot be said to equal a cost-of-living index, the concept of the COLI provides the CPI's measurement objective and the standard by which we define any bias in the CPI. While all versions of the CPI only approximate the actual changes in the cost of living, the CPI-E has several additional technical limitations. First, the CPI-E may better account for the goods and services typically purchased by the elderly, but the expenditure weights for the elderly are the only difference between the CPI-E and CPI-W. These weights are based on a much smaller sample than the other two indices, making it less precise. Second, the CPI-E does not account for differences in retail outlets frequented by the aged population or the prices they pay. Finally, the purchasing population measured in the CPI-E is not necessarily identical to the Social Security beneficiary population, where more than one-fifth of OASDI beneficiaries are under age 62. Likewise, over one-fifth of persons aged 62 or older are not beneficiaries, but they are included in the CPI-E population. Finally, changes in the index used to calculate COLAs directly affect the amount of benefits paid, and as a result, projected solvency of the Social Security program. A switch to the CPI-E for the December 2006 COLA (received in January 2007) would have resulted in an average monthly benefit $0.90 higher than that received. If the December 2006 COLA had been adjusted by the Chained CPI-U instead, the average monthly benefit would have been $4.70 less than with current indexing. Any changes to the COLA that would cause faster growth in individual benefits would make the projected date of insolvency sooner, while slower growth would delay insolvency. Hobijn and Lagakos (2003) estimated that switching to the CPI-E for COLAs would move

  1. 44 CFR 208.66 - Reopening of claims for retrospective or retroactive adjustment of costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... retrospective or retroactive adjustment of costs. (a) Upon written request by the Sponsoring Agency DHS will... legally-binding determination; or (3) The Deputy Director determines that other extenuating circumstances... submission. (c) The Sponsoring Agency must notify DHS as early as practicable that it anticipates such...

  2. 78 FR 71501 - Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... Copyright Royalty Board 37 CFR Part 381 Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Final rule. SUMMARY... that colleges, universities, and other educational institutions not affiliated with National...

  3. 76 FR 74703 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... by satellite carriers under the satellite carrier compulsory license of the Copyright Act. The COLA.... Telephone: (202) 707-7658. Email: crb@loc.gov . SUPPLEMENTARY INFORMATION: The satellite carrier...

  4. 77 FR 70373 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... by satellite carriers under the satellite carrier compulsory license of the Copyright Act. The COLA.... Telephone: (202) 707-7658. Email: crb@loc.gov . SUPPLEMENTARY INFORMATION: The satellite carrier...

  5. 75 FR 75624 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... Copyright Royalty Board 37 CFR Part 386 Cost of Living Adjustment to Satellite Carrier Compulsory License... by satellite carriers under the satellite carrier compulsory license of the Copyright Act. The COLA... INFORMATION: The satellite carrier compulsory license establishes a statutory copyright licensing scheme...

  6. 5 CFR 838.923 - Cost-of-living adjustment before the death of a retiree.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Cost-of-living adjustment before the death of a retiree. 838.923 Section 838.923 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) COURT ORDERS AFFECTING RETIREMENT BENEFITS Terminology...

  7. The impact of firms' adjustments on the indirect cost of illness.

    PubMed

    Jakubczyk, Michał; Koń, Beata

    2017-02-02

    Illness-related absenteeism reduces firms' output, an effect referred to as indirect cost (IC) and often included in cost-of-illness or cost-effectiveness (of health technologies) studies. The companies may foresee this effect and modify hiring or contracting policies. We present a model allowing the estimation of IC with such adjustments. We show that the risk of illness does not change the general shape and properties of the (expected) marginal productivity function. We apply our model to several illustrative examples and show that firm's adjustments impact IC in an ambiguous way, depending on detailed company/market characteristics: in some cases the company reduces the employment (further increasing IC), in another-the opposite happens. Contrary to previous findings, teamwork and shortfall penalties may reduce IC in some settings. Our analysis highlights that IC should be split into the result of companies preparing for and actually experiencing sick leaves.

  8. Cost per QALY (Quality-Adjusted Life Year) and Lifetime Cost of Prolonged Mechanical Ventilation in Taiwan

    PubMed Central

    Hung, Mei-Chuan; Lu, Hsin-Ming; Chen, Likwang; Lin, Ming-Shian; Chen, Cheng-Ren; Yu, Chong-Jen; Wang, Jung-Der

    2012-01-01

    Introduction Patients who require prolonged mechanical ventilation (PMV) are increasing and producing financial burdens worldwide. This study determines the cost per QALY (quality-adjusted life year), out-of-pocket expenses, and lifetime costs for PMV patients stratified by underlying diseases and cognition levels. Methods A nationwide sample of 50,481 patients with continual mechanical ventilation for more than 21 days was collected during 1997–2007. After stratifying the patients according to specific diagnoses, a latent class analysis (LCA) was performed to categorise PMV patients with multiple co-morbidities into several homogeneous groups. The survival functions were estimated for individual groups using the Kaplan-Meier method and extrapolated to 300 months through a semi-parametric method. The survival functions were adjusted using an EQ-5D utility value derived from a convenience sample of 142 PMV patients to estimate quality-adjusted life expectancies (QALE). Another convenience sample of 165 patients was used to estimate the out-of-pocket expenses. The lifetime expenditures paid by the single-payer National Health Insurance (NHI) system and patients' families were estimated by multiplying average monthly expenditures by the survival probabilities and summing the values over lifetime. Results PMV therapy costs more than 100,000 U.S. dollars (USD) per QALY for all patients with poor cognition. For patients with partial cognition, PMV therapy costs less than 56,000 USD per QALY for those with liver cirrhosis, intracranial or spinal cord injuries, and 57,000–69,000 USD for patients with multiple co-morbidities under age of 65. The average lifetime cost of PMV was usually below 56,000 USD. The out-of-pocket expenses were often more than one-third of the total cost of treatment. Conclusions PMV treatment for patients with poor cognition would cost more than 5 times Taiwan's GDP (gross domestic products), or less cost-effective. The out-of-pocket expenses

  9. 24 CFR 891.140 - Development cost limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Development cost limits. 891.140 Section 891.140 Housing and Urban Development Regulations Relating to Housing and Urban Development... AND URBAN DEVELOPMENT (SECTION 8 HOUSING ASSISTANCE PROGRAMS, SECTION 202 DIRECT LOAN PROGRAM,...

  10. 24 CFR 891.853 - Development cost limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Development cost limits. 891.853 Section 891.853 Housing and Urban Development Regulations Relating to Housing and Urban Development... AND URBAN DEVELOPMENT (SECTION 8 HOUSING ASSISTANCE PROGRAMS, SECTION 202 DIRECT LOAN PROGRAM,...

  11. 32 CFR 644.521 - Limitations on clearance cost.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Limitations on clearance cost. 644.521 Section 644.521 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Clearance of Explosive Hazards and Other Contamination from...

  12. 32 CFR 644.521 - Limitations on clearance cost.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Limitations on clearance cost. 644.521 Section 644.521 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Clearance of Explosive Hazards and Other Contamination from...

  13. Maximizing cost-effectiveness by adjusting treatment strategy according to glaucoma severity

    PubMed Central

    Guedes, Ricardo Augusto Paletta; Guedes, Vanessa Maria Paletta; Gomes, Carlos Eduardo de Mello; Chaoubah, Alfredo

    2016-01-01

    Abstract Background: The aim of this study is to determine the most cost-effective strategy for the treatment of primary open-angle glaucoma (POAG) in Brazil, from the payer's perspective (Brazilian Public Health System) in the setting of the Glaucoma Referral Centers. Methods: Study design was a cost-effectiveness analysis of different treatment strategies for POAG. We developed 3 Markov models (one for each glaucoma stage: early, moderate and advanced), using a hypothetical cohort of POAG patients, from the perspective of the Brazilian Public Health System (SUS) and a horizon of the average life expectancy of the Brazilian population. Different strategies were tested according to disease severity. For early glaucoma, we compared observation, laser and medications. For moderate glaucoma, medications, laser and surgery. For advanced glaucoma, medications and surgery. Main outcome measures were ICER (incremental cost-effectiveness ratio), medical direct costs and QALY (quality-adjusted life year). Results: In early glaucoma, both laser and medical treatment were cost-effective (ICERs of initial laser and initial medical treatment over observation only, were R$ 2,811.39/QALY and R$ 3,450.47/QALY). Compared to observation strategy, the two alternatives have provided significant gains in quality of life. In moderate glaucoma population, medical treatment presented the highest costs among treatment strategies. Both laser and surgery were highly cost-effective in this group. For advanced glaucoma, both tested strategies were cost-effective. Starting age had a great impact on results in all studied groups. Initiating glaucoma therapy using laser or surgery were more cost-effective, the younger the patient. Conclusion: All tested treatment strategies for glaucoma provided real gains in quality of life and were cost-effective. However, according to the disease severity, not all strategies provided the same cost-effectiveness profile. Based on our findings, there should be a

  14. Space power using solar photovoltaic panels: costs and limitations

    SciTech Connect

    Williams, K.A.

    1986-03-01

    Solar photovoltaic panels (SPPs) have been suggested as a possible prime space power source for multi-kilowatt applications within a ballistic missile defense (BMD) system. As a first step in an attempt to assess the affordability of possible BMD space power sources, the limitations and costs of space power satellites using SSPs in conjunction with an electrochemical energy storage system have been investigated. Both high and low earth orbital missions are considered. An extensive literature search was conducted to determine values for the principal technology-driven performance and cost figures of merit. A small computer code was then developed to evaluate the total power cost, including launch, in dollars per watt of desired space power load. The unit costs obtained were found to be heavily influenced by the nature of the mission (altitude) and the attainable specific power for the two major system components.

  15. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... charge an individual entitled to benefits under Medicare for such more expensive items or services even... charges the provider is authorized to impose on individuals entitled to benefits under Medicare on account... beneficiaries if cost limits are applied to services. 413.35 Section 413.35 Public Health CENTERS FOR...

  16. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... charge an individual entitled to benefits under Medicare for such more expensive items or services even... charges the provider is authorized to impose on individuals entitled to benefits under Medicare on account... beneficiaries if cost limits are applied to services. 413.35 Section 413.35 Public Health CENTERS FOR...

  17. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... charge an individual entitled to benefits under Medicare for such more expensive items or services even... charges the provider is authorized to impose on individuals entitled to benefits under Medicare on account... beneficiaries if cost limits are applied to services. 413.35 Section 413.35 Public Health CENTERS FOR...

  18. 42 CFR 413.35 - Limitations on coverage of costs: Charges to beneficiaries if cost limits are applied to services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... charge an individual entitled to benefits under Medicare for such more expensive items or services even... charges the provider is authorized to impose on individuals entitled to benefits under Medicare on account... beneficiaries if cost limits are applied to services. 413.35 Section 413.35 Public Health CENTERS FOR...

  19. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  20. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  1. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  2. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  3. 25 CFR 175.12 - Procedures for adjusting electric power rates except for adjustments due to changes in the cost...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Procedures for adjusting electric power rates except for... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.12 Procedures for adjusting electric power rates except...

  4. Cost analysis of adjustments of the epidemiological surveillance system to mass gatherings.

    PubMed

    Zieliński, Andrzej

    2011-01-01

    The article deals with the problem of economical analysis of public health activities at mass gatherings. After presentation of elementary review of basic economical approaches to cost analysis author tries to analyze applicability of those methods to planning of mass gatherings. Difficulties in comparability of different events and lack of the outcome data at the stage of planning make most of the economic approaches unsuitable to application at the planning stage. Even applicability of cost minimization analysis may be limited to comparison of predicted costs of preconceived standards of epidemiological surveillance. Cost effectiveness performed ex post after the event when both costs and obtained effects are known, may bring more information for future selection of most effective procedures.

  5. High feeding costs limit dive time in the largest whales.

    PubMed

    Acevedo-Gutiérrez, A; Croll, D A; Tershy, B R

    2002-06-01

    Large body size usually extends dive duration in air-breathing vertebrates. However, the two largest predators on earth, the blue whale (Balaenoptera musculus) and the fin whale (B. physalus), perform short dives for their size. Here, we test the hypothesis that the foraging behavior of these two species (lunge-feeding) is energetically expensive and limits their dive duration. We estimated the cost of lunge-feeding in both species using an approach that combined attaching time/depth recorders to seven blue whales and eight fin whales and comparing the collected dive information with predictions made by optimality models of dive behavior. We show that the rate at which whales recovered from a foraging dive was twice that of a non-foraging dive and that the cost of foraging relative to the cost of travel to and from the prey patch was 3.15 in blue whales (95 % CI 2.58-3.72) and 3.60 in fin whales (95 % CI 2.35-4.85). Whales foraged in small areas (<1 km(2)) and foraging bouts lasted more than one dive, indicating that prey did not disperse and thus that prey dispersal could not account for the limited dive durations of the whales. Despite the enormous size of blue whales and fin whales, the high energetic costs of lunge-feeding confine them to short durations of submergence and to areas with dense prey aggregations. As a corollary, because of their limited foraging time under water, these whales may be particularly vulnerable to perturbations in prey abundance.

  6. Adjustment Costs, Firm Responses, and Micro vs. Macro Labor Supply Elasticities: Evidence from Danish Tax Records*

    PubMed Central

    Chetty, Raj; Friedman, John N.; Olsen, Tore; Pistaferri, Luigi

    2011-01-01

    We show that the effects of taxes on labor supply are shaped by interactions between adjustment costs for workers and hours constraints set by firms. We develop a model in which firms post job offers characterized by an hours requirement and workers pay search costs to find jobs. We present evidence supporting three predictions of this model by analyzing bunching at kinks using Danish tax records. First, larger kinks generate larger taxable income elasticities. Second, kinks that apply to a larger group of workers generate larger elasticities. Third, the distribution of job offers is tailored to match workers' aggregate tax preferences in equilibrium. Our results suggest that macro elasticities may be substantially larger than the estimates obtained using standard microeconometric methods. PMID:21836746

  7. Quality-adjusted cost of care: a meaningful way to measure growth in innovation cost versus the value of health gains.

    PubMed

    Lakdawalla, Darius; Shafrin, Jason; Lucarelli, Claudio; Nicholson, Sean; Khan, Zeba M; Philipson, Tomas J

    2015-04-01

    Technology drives both health care spending and health improvement. Yet policy makers rarely see measures of cost growth that account for both effects. To fill this gap, we present the quality-adjusted cost of care, which illustrates cost growth net of growth in the value of health improvements, measured as survival gains multiplied by the value of survival. We applied the quality-adjusted cost of care to two cases. For colorectal cancer, drug cost per patient increased by $34,493 between 1998 and 2005 as a result of new drug launches, but value from offsetting health improvements netted a modest $1,377 increase in quality-adjusted cost of care. For multiple myeloma, new therapies increased treatment cost by $72,937 between 2004 and 2009, but offsetting health benefits lowered overall quality-adjusted cost of care by $67,863. However, patients with multiple myeloma on established first-line therapies saw costs rise without corresponding benefits. All three examples document rapid cost growth, but they provide starkly different answers to the question of whether society got what it paid for.

  8. 26 CFR 1.415(d)-1 - Cost-of-living adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... adjustment factor—(A) Adjustment factor. The adjustment factor for a calendar year is equal to a fraction... factor for the calendar year is equal to one. (B) Base period. For the purpose of adjusting the dollar... chapter. (ii) Annual adjustment factor. The annual adjustment factor for a calendar year is equal to...

  9. Empirical Assessment of Spatial Prediction Methods for Location Cost Adjustment Factors.

    PubMed

    Migliaccio, Giovanni C; Guindani, Michele; D'Incognito, Maria; Zhang, Linlin

    2013-07-01

    In the feasibility stage, the correct prediction of construction costs ensures that budget requirements are met from the start of a project's lifecycle. A very common approach for performing quick-order-of-magnitude estimates is based on using Location Cost Adjustment Factors (LCAFs) that compute historically based costs by project location. Nowadays, numerous LCAF datasets are commercially available in North America, but, obviously, they do not include all locations. Hence, LCAFs for un-sampled locations need to be inferred through spatial interpolation or prediction methods. Currently, practitioners tend to select the value for a location using only one variable, namely the nearest linear-distance between two sites. However, construction costs could be affected by socio-economic variables as suggested by macroeconomic theories. Using a commonly used set of LCAFs, the City Cost Indexes (CCI) by RSMeans, and the socio-economic variables included in the ESRI Community Sourcebook, this article provides several contributions to the body of knowledge. First, the accuracy of various spatial prediction methods in estimating LCAF values for un-sampled locations was evaluated and assessed in respect to spatial interpolation methods. Two Regression-based prediction models were selected, a Global Regression Analysis and a Geographically-weighted regression analysis (GWR). Once these models were compared against interpolation methods, the results showed that GWR is the most appropriate way to model CCI as a function of multiple covariates. The outcome of GWR, for each covariate, was studied for all the 48 states in the contiguous US. As a direct consequence of spatial non-stationarity, it was possible to discuss the influence of each single covariate differently from state to state. In addition, the article includes a first attempt to determine if the observed variability in cost index values could be, at least partially explained by independent socio-economic variables.

  10. Empirical Assessment of Spatial Prediction Methods for Location Cost Adjustment Factors

    PubMed Central

    Migliaccio, Giovanni C.; Guindani, Michele; D'Incognito, Maria; Zhang, Linlin

    2014-01-01

    In the feasibility stage, the correct prediction of construction costs ensures that budget requirements are met from the start of a project's lifecycle. A very common approach for performing quick-order-of-magnitude estimates is based on using Location Cost Adjustment Factors (LCAFs) that compute historically based costs by project location. Nowadays, numerous LCAF datasets are commercially available in North America, but, obviously, they do not include all locations. Hence, LCAFs for un-sampled locations need to be inferred through spatial interpolation or prediction methods. Currently, practitioners tend to select the value for a location using only one variable, namely the nearest linear-distance between two sites. However, construction costs could be affected by socio-economic variables as suggested by macroeconomic theories. Using a commonly used set of LCAFs, the City Cost Indexes (CCI) by RSMeans, and the socio-economic variables included in the ESRI Community Sourcebook, this article provides several contributions to the body of knowledge. First, the accuracy of various spatial prediction methods in estimating LCAF values for un-sampled locations was evaluated and assessed in respect to spatial interpolation methods. Two Regression-based prediction models were selected, a Global Regression Analysis and a Geographically-weighted regression analysis (GWR). Once these models were compared against interpolation methods, the results showed that GWR is the most appropriate way to model CCI as a function of multiple covariates. The outcome of GWR, for each covariate, was studied for all the 48 states in the contiguous US. As a direct consequence of spatial non-stationarity, it was possible to discuss the influence of each single covariate differently from state to state. In addition, the article includes a first attempt to determine if the observed variability in cost index values could be, at least partially explained by independent socio-economic variables. PMID

  11. Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model.

    PubMed

    Andersen, M E; MacNaughton, M G; Clewell, H J; Paustenbach, D J

    1987-04-01

    The rationale for adjusting occupational exposure limits for unusual work schedules is to assure, as much as possible, that persons on these schedules are placed at no greater risk of injury or discomfort than persons who work a standard 8 hr/day, 40 hr/week. For most systemic toxicants, the risk index upon which the adjustments are made will be either peak blood concentration or integrated tissue dose, depending on what chemical's presumed mechanism of toxicity. Over the past ten years, at least four different models have been proposed for adjusting exposure limits for unusually short and long work schedules. This paper advocates use of a physiologically-based pharmacokinetic (PB-PK) model for determining adjustment factors for unusual exposure schedules, an approach that should be more accurate than those proposed previously. The PB-PK model requires data on the blood:air and tissue:blood partition coefficients, the rate of metabolism of the chemical, organ volumes, organ blood flows and ventilation rates in humans. Laboratory data on two industrially important chemicals--styrene and methylene chloride--were used to illustrate the PB-PK approach. At inhaled concentrations near their respective 8-hr Threshold Limit Value-Time-weighted averages (TLV-TWAs), both of these chemicals are primarily eliminated from the body by metabolism. For these two chemicals, the appropriate risk indexing parameters are integrated tissue dose or total amount of parent chemical metabolized. Since methylene chloride is metabolized to carbon monoxide, the maximum blood carboxyhemoglobin concentrations also might be useful as an index of risk for this chemical.(ABSTRACT TRUNCATED AT 250 WORDS)

  12. The Role of Inflation and Price Escalation Adjustments in Properly Estimating Program Costs: F-35 Case Study

    DTIC Science & Technology

    2016-04-30

    policies and the cost , measurement , and enhancement of readiness. Recently he has also been studying the use of inflation indexes in the DoD. He has...use a price index when normalizing historical cost data to a common point in time (where the normalized costs are referred to as “base year” [BY...expressed in TY (nominal) dollars. In CER development, adjustments needed to normalize historical cost data to BY dollars used as the dependent variable

  13. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  14. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  15. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  16. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  17. 25 CFR 175.13 - Procedures for adjusting electric power rates to reflect changes in the cost of purchased power...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Procedures for adjusting electric power rates to reflect..., DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Service Fees, Electric Power Rates and Revenues § 175.13 Procedures for adjusting electric power rates to reflect changes in the cost...

  18. Daphnia's dilemma: adjustment of carbon budgets in the face of food and cholesterol limitation.

    PubMed

    Lukas, Marcus; Wacker, Alexander

    2014-04-01

    We studied the carbon (C) metabolism in Daphnia when the amount of C (food quantity) and/or the content of biochemical nutrients (food quality) was limiting. Growth performances and C budgets of Daphnia magna (assimilation, faeces egestion, excretion and respiration measured by [(14)C]-tracing) were analysed when animals were raised on different food quantities and concentrations of cholesterol, an essential biochemical food compound. Cholesterol is of special interest because it not only acts as limiting nutrient but also contributes to the overall C pool of the animals. As the tissue cholesterol concentration in Daphnia is quite low, we hypothesized the selective exclusion of cholesterol from C budgeting and tested this using radiolabelled cholesterol. Somatic growth rates of D. magna were highest at high quantity and quality and were reduced to a moderate value if either the food quantity or the cholesterol concentration was low. Growth was lowest at low food quantity and quality. The measurements of C budgets revealed high regulative response to low food quality at high food quantity only. Here, low dietary cholesterol caused bulk C assimilation efficiency (AE) to decrease and assimilated (excess) C to be increasingly respired. Additionally, Daphnia enhanced efficient adjustment of C budgets when facing cholesterol limitation by (1) increasing the AE of the cholesterol itself and (2) not changing cholesterol respiration, which was still not detectable. In contrast, at low food quantity, Daphnia is unable to adjust for low food quality, emphasizing that food limitation could overrule food quality effects.

  19. Army ants dynamically adjust living bridges in response to a cost-benefit trade-off.

    PubMed

    Reid, Chris R; Lutz, Matthew J; Powell, Scott; Kao, Albert B; Couzin, Iain D; Garnier, Simon

    2015-12-08

    The ability of individual animals to create functional structures by joining together is rare and confined to the social insects. Army ants (Eciton) form collective assemblages out of their own bodies to perform a variety of functions that benefit the entire colony. Here we examine ‟bridges" of linked individuals that are constructed to span gaps in the colony's foraging trail. How these living structures adjust themselves to varied and changing conditions remains poorly understood. Our field experiments show that the ants continuously modify their bridges, such that these structures lengthen, widen, and change position in response to traffic levels and environmental geometry. Ants initiate bridges where their path deviates from their incoming direction and move the bridges over time to create shortcuts over large gaps. The final position of the structure depended on the intensity of the traffic and the extent of path deviation and was influenced by a cost-benefit trade-off at the colony level, where the benefit of increased foraging trail efficiency was balanced by the cost of removing workers from the foraging pool to form the structure. To examine this trade-off, we quantified the geometric relationship between costs and benefits revealed by our experiments. We then constructed a model to determine the bridge location that maximized foraging rate, which qualitatively matched the observed movement of bridges. Our results highlight how animal self-assemblages can be dynamically modified in response to a group-level cost-benefit trade-off, without any individual unit's having information on global benefits or costs.

  20. 24 CFR 905.314 - Cost and other limitations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... & Swift cost index for construction of “good” quality. HUD has the discretion to change the cost indices... index for construction of “average” quality and the Marshal & Swift cost index for construction of...

  1. 42 CFR 417.588 - Computation of adjusted average per capita cost (AAPCC).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... computing the AAPCC. (c) Adjustment factors—(1) Geographic. CMS makes an adjustment to reflect the relative...) Age, sex, and disability status. CMS makes adjustments to reflect the age and sex distribution and...

  2. 42 CFR 417.588 - Computation of adjusted average per capita cost (AAPCC).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... computing the AAPCC. (c) Adjustment factors—(1) Geographic. CMS makes an adjustment to reflect the relative...) Age, sex, and disability status. CMS makes adjustments to reflect the age and sex distribution and...

  3. Adjustment of costly extra-group paternity according to inbreeding risk in a cooperative mammal

    PubMed Central

    Cant, Michael A.; Sanderson, Jennifer L.

    2015-01-01

    Females of many animal species seek mating opportunities with multiple males, despite being able to obtain sufficient sperm to father their offspring from a single male. In animals that live in stable social groups, females often choose to mate outside their group resulting in extra-group paternity (EGP). One reason proposed to explain female choice for extra-group males is to obtain compatible genes, for example, in order to avoid inbreeding depression in offspring. The benefits of such extra-group paternities could be substantial if they result in fitter, outbred offspring. However, avoiding inbreeding in this way could be costly for females, for example, through retaliation by cuckolded males or through receiving aggression while prospecting for extra-group mating opportunities. We investigate the costs and benefits of EGP in the banded mongoose Mungos mungo, a cooperatively breeding mammal in which within-group mates are sometimes close relatives. We find that pups born to females that mate with extra-group males are more genetically heterozygous are heavier and are more likely to survive to independence than pups born to females that mate within their group. However, extra-group matings also involve substantial costs as they occur during violent encounters that sometimes result in injury and death. This appears to lead femalebanded mongooses to adaptively adjust EGP levels according to the current risk of inbreeding associated with mating within the group. For group-living animals, the costs of intergroup interactions may help to explain variation in both inbreeding rates and EGP within and between species. PMID:26609201

  4. Applying risk adjusted cost-effectiveness (RAC-E) analysis to hospitals: estimating the costs and consequences of variation in clinical practice.

    PubMed

    Karnon, Jonathan; Caffrey, Orla; Pham, Clarabelle; Grieve, Richard; Ben-Tovim, David; Hakendorf, Paul; Crotty, Maria

    2013-06-01

    Cost-effectiveness analysis is well established for pharmaceuticals and medical technologies but not for evaluating variations in clinical practice. This paper describes a novel methodology--risk adjusted cost-effectiveness (RAC-E)--that facilitates the comparative evaluation of applied clinical practice processes. In this application, risk adjustment is undertaken with a multivariate matching algorithm that balances the baseline characteristics of patients attending different settings (e.g., hospitals). Linked, routinely collected data are used to analyse patient-level costs and outcomes over a 2-year period, as well as to extrapolate costs and survival over patient lifetimes. The study reports the relative cost-effectiveness of alternative forms of clinical practice, including a full representation of the statistical uncertainty around the mean estimates. The methodology is illustrated by a case study that evaluates the relative cost-effectiveness of services for patients presenting with acute chest pain across the four main public hospitals in South Australia. The evaluation finds that services provided at two hospitals were dominated, and of the remaining services, the more effective hospital gained life years at a low mean additional cost and had an 80% probability of being the most cost-effective hospital at realistic cost-effectiveness thresholds. Potential determinants of the estimated variation in costs and effects were identified, although more detailed analyses to identify specific areas of variation in clinical practice are required to inform improvements at the less cost-effective institutions.

  5. Costing the Morbidity and Mortality Consequences of Zoonoses Using Health-Adjusted Life Years.

    PubMed

    Jordan, H; Dunt, D; Hollingsworth, B; Firestone, S M; Burgman, M

    2016-10-01

    Governments are routinely involved in the biosecurity of agricultural and food imports and exports. This involves controlling the complex ongoing threat of the broad range of zoonoses: endemic, exotic and newly emerging. Policy-related decision-making in these areas requires accurate information and predictions concerning the effects and potential impacts of zoonotic diseases. The aim of this article was to provide information concerning the development and use of utility-based tools, specifically disability-adjusted life years (DALYs), for measuring the burden on human disease (morbidity and mortality) as a consequence of zoonotic infections. Issues and challenges to their use are also considered. Non-monetary utility approaches that are reviewed in this paper form one of a number of tools that can be used to estimate the monetary and non-monetary 'cost' of morbidity- and mortality-related consequences. Other tools derive from cost-of-illness, willingness-to-pay and multicriteria approaches. Utility-based approaches are specifically designed to capture the pain, suffering and loss of functioning associated with diseases, zoonotic and otherwise. These effects are typically complicated to define, measure and subsequently 'cost'. Utility-based measures will not be able to capture all of the effects, especially those that extend beyond the health sector. These will more normally be captured in financial terms. Along with other uncommon diseases, the quality of the relevant epidemiological data may not be adequate to support the estimation of losses in utility as a result of zoonoses. Other issues in their use have been identified. New empirical studies have shown some success in addressing these issues. Other issues await further study. It is concluded that, bearing in mind all caveats, utility-based methods are important tools in assessing the magnitude of the impacts of zoonoses in human disease. They make an important contribution to decision-making and priority

  6. 42 CFR 447.78 - Aggregate limits on alternative premiums and cost sharing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Aggregate limits on alternative premiums and cost... Provisions Alternative Premiums and Cost Sharing Under Section 1916a § 447.78 Aggregate limits on alternative premiums and cost sharing. (a) The total aggregate amount of premiums and cost sharing imposed...

  7. Reverse-total shoulder arthroplasty cost-effectiveness: A quality-adjusted life years comparison with total hip arthroplasty

    PubMed Central

    Bachman, Daniel; Nyland, John; Krupp, Ryan

    2016-01-01

    AIM: To compare reverse-total shoulder arthroplasty (RSA) cost-effectiveness with total hip arthroplasty cost-effectiveness. METHODS: This study used a stochastic model and decision-making algorithm to compare the cost-effectiveness of RSA and total hip arthroplasty. Fifteen patients underwent pre-operative, and 3, 6, and 12 mo post-operative clinical examinations and Short Form-36 Health Survey completion. Short form-36 Health Survey subscale scores were converted to EuroQual Group Five Dimension Health Outcome scores and compared with historical data from age-matched patients who had undergone total hip arthroplasty. Quality-adjusted life year (QALY) improvements based on life expectancies were calculated. RESULTS: The cost/QALY was $3900 for total hip arthroplasty and $11100 for RSA. After adjusting the model to only include shoulder-specific physical function subscale items, the RSA QALY improved to 2.8 years, and its cost/QALY decreased to $8100. CONCLUSION: Based on industry accepted standards, cost/QALY estimates supported both RSA and total hip arthroplasty cost-effectiveness. Although total hip arthroplasty remains the quality of life improvement “gold standard” among arthroplasty procedures, cost/QALY estimates identified in this study support the growing use of RSA to improve patient quality of life. PMID:26925384

  8. Doing More Harm than Good? A Commentary on the Politics of Cost Adjustments for Wage Variation in State School Finance Formulas

    ERIC Educational Resources Information Center

    Baker, Bruce D.

    2008-01-01

    This article addresses the design and application of cost adjustments in state school finance policies intended to compensate local public school districts for differences in the costs of recruiting and retaining teachers. Broadly speaking, the state policy objective for including cost adjustments to state aid for such things as teacher cost…

  9. 47 CFR 36.602 - Calculation of non-rural carrier portion of nationwide loop cost expense adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the total loop cost expense adjustment for the immediately preceding calendar year, increased by a rate equal to the rate of increase in the total number of working loops during the calendar year... loops on December 31 of the calendar year preceding the July 31st filing and the number of total...

  10. 48 CFR 252.247-7003 - Pass-Through of Motor Carrier Fuel Surcharge Adjustment To The Cost Bearer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pass-Through of Motor... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.247-7003 Pass-Through of Motor...: PASS-THROUGH OF MOTOR CARRIER FUEL SURCHARGE ADJUSTMENT TO THE COST BEARER (SEP 2010) (a) This...

  11. A Cost-Effective Fluorescence Mini-Microscope with Adjustable Magnifications for Biomedical Applications

    PubMed Central

    Zhang, Yu Shrike; Ribas, João; Nadhman, Akhtar; Aleman, Julio; Selimović, Šeila; Lesher-Perez, Sasha Cai; Wang, Ting; Manoharan, Vijayan; Shin, Su-Ryon; Damilano, Alessia; Annabi, Nasim; Dokmeci, Mehmet Remzi; Takayama, Shuichi; Khademhosseini, Ali

    2015-01-01

    We have designed and fabricated a miniature microscope from off-the-shelf components and webcam, with built-in fluorescence capability for biomedical applications. The mini-microscope was able to detect both biochemical parameters such as cell/tissue viability (e.g. Live/Dead assay), and biophysical properties of the microenvironment such as oxygen levels in microfabricated tissues based on an oxygen-sensitive fluorescent dye. This mini-microscope has adjustable magnifications from 8-60X, achieves a resolution as high as <2 μm, and possesses a long working distance of 4.5 mm (at a magnification of 8X). The mini-microscope was able to chronologically monitor cell migration and analyze beating of microfluidic liver and cardiac bioreactors in real time, respectively. The mini-microscope system is cheap, and its modularity allows convenient integration with a wide variety of pre-existing platforms including but not limited to, cell culture plates, microfluidic devices, and organs-on-a-chip systems. Therefore, we envision its widespread applications in cell biology, tissue engineering, biosensing, microfluidics, and organs-on-chips, which can potentially replace conventional bench-top microscopy where long-term in situ and large-scale imaging/analysis is required. PMID:26282117

  12. Risk-adjusted impact of administrative costs on the distribution of terminal wealth for long-term investment.

    PubMed

    Guillén, Montserrat; Jarner, Søren Fiig; Nielsen, Jens Perch; Pérez-Marín, Ana M

    2014-01-01

    The impact of administrative costs on the distribution of terminal wealth is approximated using a simple formula applicable to many investment situations. We show that the reduction in median returns attributable to administrative fees is usually at least twice the amount of the administrative costs charged for most investment funds, when considering a risk-adjustment correction over a reasonably long-term time horizon. The example we present covers a number of standard cases and can be applied to passive investments, mutual funds, and hedge funds. Our results show investors the potential losses they face in performance due to administrative costs.

  13. 38 CFR 3.28 - Automatic adjustment of section 306 and old-law pension income limitations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... section 306 and old-law pension income limitations. 3.28 Section 3.28 Pensions, Bonuses, and Veterans... Compensation General § 3.28 Automatic adjustment of section 306 and old-law pension income limitations. Whenever the maximum annual rates of improved pension are increased by reason of the provisions of 38...

  14. 38 CFR 3.28 - Automatic adjustment of section 306 and old-law pension income limitations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... section 306 and old-law pension income limitations. 3.28 Section 3.28 Pensions, Bonuses, and Veterans... Compensation General § 3.28 Automatic adjustment of section 306 and old-law pension income limitations. Whenever the maximum annual rates of improved pension are increased by reason of the provisions of 38...

  15. 76 FR 79545 - Cost Accounting Standards: Change to the CAS Applicability Threshold for the Inflation Adjustment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... to the CAS Applicability Threshold for the Inflation Adjustment to the Truth in Negotiations Act... Negotiations Act (TINA) threshold, as adjusted for inflation.'' The change is being made because the CAS...) applicability threshold in 48 CFR Chapter 99 from ``$650,000'' to ``the Truth in Negotiations Act...

  16. 76 FR 40817 - Cost Accounting Standards: Change to the CAS Applicability Threshold for the Inflation Adjustment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... to the CAS Applicability Threshold for the Inflation Adjustment to the Truth in Negotiations Act... revising the threshold for the application of CAS from ``$650,000'' to ``the Truth in Negotiations Act... Negotiations Act (TINA) threshold, as adjusted for inflation (41 U.S.C. 1908) and (41 U.S.C....

  17. Performance of adjustable pressure-limiting (APL) valves in two different modern anaesthesia machines.

    PubMed

    Thomas, J; Weiss, M; Schmidt, A R; Buehler, P K

    2017-01-01

    The ability to gently ventilate a patient's lungs using a self-inflating bag requires a properly working adjustable pressure-limiting (APL) valve. We compared the performance of the APL valves of the GE Aisys CS(2) and the Draeger Fabius anaesthetic machines during closure and opening from 1-20 and from 20-1 cmH2 O, using standardised experimental baby and adolescent patient lung models. Airway pressures and inspiratory tidal volumes were measured using an ASL-5000 test lung and a GE Aisys CS(2) near-patient spirometry sensors. In both lung models, the GE Aisys CS(2) APL valves demonstrated non-linear behaviours for airway pressures and for inspiratory tidal volumes, with a sharp increase at set APL pressure levels of 8-10 cmH2 O. With further closure of the GE Aisys CS(2) APL valves up to 20 cmH2 O, inspiratory tidal volumes decreased to ~50% of the highest values measured. Airway pressures in the Draeger Fabius APL valves demonstrated a near linear increase and decrease. Airway pressure values measured in the Draeger Fabius were never higher than those set by the APL valves, whereas in the GE Aisys CS(2) , they considerably exceeded set pressures (by up to 27 cmH2 O). We conclude that the performance of the GE Aisys CS(2) APL valve does not allow safe bag-assisted ventilation of a patient's lungs.

  18. Alpine scree plants benefit from cryptic coloration with limited cost.

    PubMed

    Niu, Yang; Sun, Hang

    2014-01-01

    Like animals, plants are attacked by enemies (herbivores) that forage using visual cues; however, the defensive coloration type known as cryptic coloration was rarely reported in plants. For most autotrophic plants, because photosynthesis relies on the presence of chlorophyll, a green leaf appearance is standard. However, if having leaves that are not green is more beneficial than costly, such coloration may evolve under certain conditions. Taking advantage of the leaf color dimorphism of Corydalis benecincta, we showed that the cryptically colored leaves confer a clear benefit without obvious cost in natural populations. Based on this study, we try to provide a framework on which to base a cost-benefit analysis to investigate the evolution of cryptic leaf coloration in plants.

  19. 48 CFR 42.707 - Cost-sharing rates and limitations on indirect cost rates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ceiling may be incorporated into the contract for prospective application. For cost sharing under research... contractor— (i) Is a new or recently reorganized company, and there is no past or recent record of incurred indirect costs; (ii) Has a recent record of a rapidly increasing indirect cost rate due to a...

  20. 34 CFR 609.41 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are allowable costs and what are the limitations on allowable costs? 609.41 Section 609.41 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STRENGTHENING...

  1. 34 CFR 608.40 - What are allowable costs and what are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are allowable costs and what are the limitations on allowable costs? 608.40 Section 608.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STRENGTHENING...

  2. 45 CFR 800.106 - Cost-sharing limits, advance payments of premium tax credits, and cost-sharing reductions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Cost-sharing limits, advance payments of premium tax credits, and cost-sharing reductions. 800.106 Section 800.106 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF PERSONNEL MANAGEMENT MULTI-STATE PLAN PROGRAM...

  3. 45 CFR 800.106 - Cost-sharing limits, advance payments of premium tax credits, and cost-sharing reductions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Cost-sharing limits, advance payments of premium tax credits, and cost-sharing reductions. 800.106 Section 800.106 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF PERSONNEL MANAGEMENT MULTI-STATE PLAN PROGRAM...

  4. Efficient and Cost-Effective Use of Adjustable Canopy Hoods in a Chemistry Laboratory.

    ERIC Educational Resources Information Center

    Rothchild, Robert

    1988-01-01

    Suggests the use of small canopy hoods that provide flexibility of vertical and horizontal adjustment over the lab bench as a replacement for permanent hoods. Includes many safety related instances where canopy hoods should be used. (MVL)

  5. Short-term heat stress exposure limits based on wet bulb globe temperature adjusted for clothing and metabolic rate.

    PubMed

    Bernard, Thomas E; Ashley, Candi D

    2009-10-01

    Most heat stress exposure assessments based on wet bulb globe temperature (WBGT) consider the environmental conditions, metabolic demands, and clothing requirements, and the exposure limit is for extended work periods (e.g., a typical workday). The U.S. Navy physiological heat exposure limit (PHEL) curves and rational models of heat stress also consider time as a job risk factor so that there is a limiting time for exposures above a conventional WBGT exposure limit. The PHEL charts have not been examined for different clothing and the rational models require personal computers. The current study examined the role of clothing in short-term (time limited) exposures and proposed a relationship between a Safe Exposure Time and WBGT adjusted for clothing and metabolic rate. Twelve participants worked at a metabolic rate of 380 W in three clothing ensembles [clothing adjustment factors]: (1) work clothes (0 degrees C-WBGT), (2) NexGen microporous coveralls (2.5 degrees C-WBGT), and (2) vapor-barrier coveralls (6.5 degrees C-WBGT) at five levels of heat stress (approximately at the clothing adjusted TLV plus 7.0, 8.0, 9.5, 11.5 and 15.0 degrees C-WBGT). The combinations of metabolic rate, clothing, and environment were selected in anticipation that the participants would reach a physiological limit in less than 120 min. WBGT-based clothing adjustment factors were used to account for different clothing ensembles, and no differences were found for ensemble, which meant that the clothing adjustment factor can be used in WBGT-based time limited exposures. An equation was proposed to recommend a Safe Exposure Time for exposures under 120 min. The recommended times were longer than the PHEL times or times from a rational model of heat stress.

  6. 78 FR 69778 - Adjustments to Limitations on Designated School Official Assignment and Study by F-2 and M-2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... United States On September 16, 2011, Secretary of Homeland Security Janet Napolitano announced a ``Study...; ] DEPARTMENT OF HOMELAND SECURITY 8 CFR Part 214 RIN 1653-AA63 Adjustments to Limitations on Designated School Official Assignment and Study by F-2 and M-2 Nonimmigrants AGENCY: U.S. Immigration and Customs...

  7. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) shall be the cost of: (i) Fossil and nuclear fuel consumed in the utility's own plants, and the utility's share of fossil and nuclear fuel consumed in jointly owned or leased plants. (ii) The actual identifiable fossil and nuclear fuel costs associated with energy purchased for reasons other than...

  8. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) shall be the cost of: (i) Fossil and nuclear fuel consumed in the utility's own plants, and the utility's share of fossil and nuclear fuel consumed in jointly owned or leased plants. (ii) The actual identifiable fossil and nuclear fuel costs associated with energy purchased for reasons other than...

  9. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) shall be the cost of: (i) Fossil and nuclear fuel consumed in the utility's own plants, and the utility's share of fossil and nuclear fuel consumed in jointly owned or leased plants. (ii) The actual identifiable fossil and nuclear fuel costs associated with energy purchased for reasons other than...

  10. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) shall be the cost of: (i) Fossil and nuclear fuel consumed in the utility's own plants, and the utility's share of fossil and nuclear fuel consumed in jointly owned or leased plants. (ii) The actual identifiable fossil and nuclear fuel costs associated with energy purchased for reasons other than...

  11. 18 CFR 35.14 - Fuel cost and purchased economic power adjustment clauses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) shall be the cost of: (i) Fossil and nuclear fuel consumed in the utility's own plants, and the utility's share of fossil and nuclear fuel consumed in jointly owned or leased plants. (ii) The actual identifiable fossil and nuclear fuel costs associated with energy purchased for reasons other than...

  12. A Comparable Wage Approach to Geographic Cost Adjustment. Research and Development Report. NCES-2006-321

    ERIC Educational Resources Information Center

    Taylor, Lori L.; Fowler, William J. Jr.

    2006-01-01

    Geographic cost differences present many complications when researchers attempt to make systematic comparisons of educational resources, and failure to address such differences can undermine the equity and adequacy goals of school finance formulas. Therefore, there is considerable interest in developing measures of the cost of education that can…

  13. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... percentage (if any) for each civil monetary penalty by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment, exceeds the Consumer Price Index for the month of June... 75,000 80,000 46 U.S.C. 42104 Failure to provide required reports, etc./Merchant Marine Act of 1920...

  14. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... percentage (if any) for each civil monetary penalty by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment, exceeds the Consumer Price Index for the month of June... tariff suspension 60,000 75,000 46 U.S.C. 42104 Failure to provide required reports, etc./Merchant...

  15. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... percentage (if any) for each civil monetary penalty by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment, exceeds the Consumer Price Index for the month of June... Marine Act of 1920 6,000 8,000 46 U.S.C. 42106 Adverse shipping conditions/Merchant Marine Act of 1920...

  16. 46 CFR 506.4 - Cost of living adjustments of civil monetary penalties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... percentage (if any) for each civil monetary penalty by which the Consumer Price Index for the month of June of the calendar year preceding the adjustment, exceeds the Consumer Price Index for the month of June... tariff suspension 60,000 75,000 46 U.S.C. 42104 Failure to provide required reports, etc./Merchant...

  17. 45 CFR 2540.110 - Limitation on use of Corporation funds for administrative costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... administrative costs. 2540.110 Section 2540.110 Public Welfare Regulations Relating to Public Welfare (Continued... Corporation will approve one of the following methods in the award document: (i) Limit the amount or rate of... Federal awards will be limited to this method; and (B) Unreimbursed indirect costs may be applied...

  18. 76 FR 8293 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits...) computes and publishes the project cost and annual limits for natural gas pipelines blanket construction... practice and procedure, Natural Gas, Reporting and recordkeeping requirements. Jeff C. Wright,...

  19. 78 FR 8389 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits AGENCY... publishes the project cost and annual limits for natural gas pipelines blanket construction certificates for... CFR Part 157 Administrative practice and procedure, Natural Gas, Reporting and...

  20. 77 FR 8724 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits... (OEP) computes and publishes the project cost and annual limits for natural gas pipelines blanket..., Natural gas, Reporting and recordkeeping requirements. Jeff C. Wright, Director, Office of Energy...

  1. 75 FR 8245 - Natural Gas Pipelines; Project Cost and Annual Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Energy Regulatory Commission 18 CFR Part 157 Natural Gas Pipelines; Project Cost and Annual Limits...) computes and publishes the project cost and annual limits for natural gas pipelines blanket construction... Part 157 Administrative practice and procedure, Natural gas, Reporting and recordkeeping...

  2. 34 CFR 656.30 - What are allowable costs and limitations on allowable costs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... costs? 656.30 Section 656.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR...; and (8) Summer institutes in the United States or abroad designed to provide language and...

  3. 34 CFR 656.30 - What are allowable costs and limitations on allowable costs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... costs? 656.30 Section 656.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR...; and (8) Summer institutes in the United States or abroad designed to provide language and...

  4. 34 CFR 656.30 - What are allowable costs and limitations on allowable costs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... costs? 656.30 Section 656.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR...; and (8) Summer institutes in the United States or abroad designed to provide language and...

  5. 34 CFR 656.30 - What are allowable costs and limitations on allowable costs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... costs? 656.30 Section 656.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR...; and (8) Summer institutes in the United States or abroad designed to provide language and...

  6. A Cost-effectiveness Analysis of Laparoscopic Gastric Bypass, Adjustable Gastric Banding and Non-Surgical Weight Loss Interventions

    PubMed Central

    Salem, Leon; Devlin, Allison; Sullivan, Sean D.; Flum, David R.

    2009-01-01

    Setting Laparoscopic adjustable gastric banding (LAGB) and Laparoscopic Roux-en-Y gastric bypass (LRYGB) are the two most commonly performed bariatric procedures. While both procedures likely reduce healthcare expenditures related to the resolution of comorbid conditions, they have different rates of perioperative risks and differential rates of associated weight loss. Objective We designed a model to evaluate the incremental cost-effectiveness (ICER) of these procedures compared to non-operative weight loss interventions and to each other. Methods Deterministic, payer-perspective model comparing the lifetime expected costs and outcomes of LAGB, LRYGB and non-surgical treatment. The major endpoints were survival, health related quality of life and weight loss. Life expectancy and lifetime medical costs were calculated across age, sex and body mass index (BMI) strata using previously published data. Results For both men and women LRYGB and LAGB were cost-effective at less than $25,000/QALY even when evaluating the full range of baseline BMI and estimates of adverse outcomes, weight loss and costs. For base-case scenarios in men (age 35, BMI 40) the ICER was $11,604 per QALY for LAGB, compared to $18,543 per QALY for LRYGB. For base-case scenarios in women (age 35, BMI 40) the ICER was $8,878 per QALY for LAGB, compared to $14,680 per QALY for LRYGB. Conclusions Modeled cost-effectiveness analysis showed that both operative interventions for morbid obesity, LAGB and RYGB, were cost-effective at less than $25,000, and LAGB was more cost-effective than RYGB for all the base-case scenarios. PMID:18069075

  7. Phenology, growth and physiological adjustments of oil palm (Elaeis guineensis) to sink limitation induced by fruit pruning

    PubMed Central

    Legros, S.; Mialet-Serra, I.; Caliman, J.-P.; Siregar, F. A.; Clement-Vidal, A.; Fabre, D.; Dingkuhn, M.

    2009-01-01

    Background and Aims Despite its simple architecture and small phenotypic plasticity, oil palm has complex phenology and source–sink interactions. Phytomers appear in regular succession but their development takes years, involving long lag periods between environmental influences and their effects on sinks. Plant adjustments to resulting source–sink imbalances are poorly understood. This study investigated oil palm adjustments to imbalances caused by severe fruit pruning. Methods An experiment with two treatments (control and complete fruit pruning) during 22 months in 2006–2008) and six replications per treatment was conducted in Indonesia. Phenology, growth of above-ground vegetative and reproductive organs, leaf morphology, inflorescence sex differentiation, dynamics of non-structural carbohydrate reserves and light-saturated net photosynthesis (Amax) were monitored. Key Results Artificial sink limitation by complete fruit pruning accelerated development rate, resulting in higher phytomer, leaf and inflorescence numbers. Leaf size and morphology remained unchanged. Complete fruit pruning also suppressed the abortion of male inflorescences, estimated to be triggered at about 16 months before bunch maturity. The number of female inflorescences increased after an estimated lag of 24–26 months, corresponding to time from sex differentiation to bunch maturity. The most important adjustment process was increased assimilate storage in the stem, attaining nearly 50 % of dry weight in the stem top, mainly as starch, whereas glucose, which in controls was the most abundant non-structural carbohydrate stored in oil palm, decreased. Conclusions The development rate of oil palm is in part controlled by source–sink relationships. Although increased rate of development and proportion of female inflorescences constituted observed adjustments to sink limitation, the low plasticity of plant architecture (constant leaf size, absence of branching) limited compensatory

  8. 75 FR 74623 - Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-01

    ..., BMI and SESAC repertories. The COLA is based on the change in the Consumer Price Index from October... publish a notice of the change in the cost of living as determined by the Consumer Price Index (all urban consumers, all items (``CPI-U'')) during the period from the most recent index published prior to...

  9. 77 FR 63324 - Notice of Certain Operating Cost Adjustment Factors for 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... CUUR0000SEHD) at the national level. Fuel Oil: The Energy Information Agency Retail Price of No. 2 Fuel Oil to..., Natural Gas, Residential Energy Price, 2010-2011 annual prices in dollars per 1,000 cubic feet at the... these areas. The best current price data sources for the nine cost categories were used in...

  10. 78 FR 56911 - Notice of Certain Operating Cost Adjustment Factors for 2014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... Bureau of Labor Statistics (BLS) Consumer Price Index, All Items Less Food, Energy and Shelter (Series ID... . Natural Gas: Energy Information Agency, Natural Gas, Residential Energy Price, 2011-2012 annual prices in... these areas. The best current price data sources for the nine cost categories were used in...

  11. Recovery of Indirect Costs in the Pricing of Equitable Adjustments and Terminations for Convenience

    DTIC Science & Technology

    1988-05-01

    28,219. But see Rossen Builders, ASBCA 32305, 87-1 BCA 19538 at 98,727-28 (prior year’s G&A rate was used by Government and accepted by Board in lieu of...3 87 See e.g., Rossen Builders, ASBCA 32305, 87-1 BCA 19538 at 98,727 (holding bid estimator’s time and delivery costs were already in G&A--allowance

  12. Constraints on the evolution of phenotypic plasticity: limits and costs of phenotype and plasticity.

    PubMed

    Murren, C J; Auld, J R; Callahan, H; Ghalambor, C K; Handelsman, C A; Heskel, M A; Kingsolver, J G; Maclean, H J; Masel, J; Maughan, H; Pfennig, D W; Relyea, R A; Seiter, S; Snell-Rood, E; Steiner, U K; Schlichting, C D

    2015-10-01

    Phenotypic plasticity is ubiquitous and generally regarded as a key mechanism for enabling organisms to survive in the face of environmental change. Because no organism is infinitely or ideally plastic, theory suggests that there must be limits (for example, the lack of ability to produce an optimal trait) to the evolution of phenotypic plasticity, or that plasticity may have inherent significant costs. Yet numerous experimental studies have not detected widespread costs. Explicitly differentiating plasticity costs from phenotype costs, we re-evaluate fundamental questions of the limits to the evolution of plasticity and of generalists vs specialists. We advocate for the view that relaxed selection and variable selection intensities are likely more important constraints to the evolution of plasticity than the costs of plasticity. Some forms of plasticity, such as learning, may be inherently costly. In addition, we examine opportunities to offset costs of phenotypes through ontogeny, amelioration of phenotypic costs across environments, and the condition-dependent hypothesis. We propose avenues of further inquiry in the limits of plasticity using new and classic methods of ecological parameterization, phylogenetics and omics in the context of answering questions on the constraints of plasticity. Given plasticity's key role in coping with environmental change, approaches spanning the spectrum from applied to basic will greatly enrich our understanding of the evolution of plasticity and resolve our understanding of limits.

  13. 48 CFR 2152.216-71 - Fixed price with limited cost redetermination-service charge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... request, OPM will furnish, during the third quarter of the current contract year, an accounting of the... cost redetermination-service charge. 2152.216-71 Section 2152.216-71 Federal Acquisition Regulations....216-71 Fixed price with limited cost redetermination—service charge. As prescribed in...

  14. 48 CFR 2152.216-70 - Fixed price with limited cost redetermination-risk charge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... request, OPM will furnish, during the third quarter of the current contract year, an accounting of the... cost redetermination-risk charge. 2152.216-70 Section 2152.216-70 Federal Acquisition Regulations....216-70 Fixed price with limited cost redetermination—risk charge. As prescribed in...

  15. Annual cost of illness and quality-adjusted life year losses in the United States due to 14 foodborne pathogens.

    PubMed

    Hoffmann, Sandra; Batz, Michael B; Morris, J Glenn

    2012-07-01

    In this article we estimate the annual cost of illness and quality-adjusted life year (QALY) loss in the United States caused by 14 of the 31 major foodborne pathogens reported on by Scallan et al. (Emerg. Infect. Dis. 17:7-15, 2011), based on their incidence estimates of foodborne illness in the United States. These 14 pathogens account for 95 % of illnesses and hospitalizations and 98 % of deaths due to identifiable pathogens estimated by Scallan et al. We estimate that these 14 pathogens cause $14.0 billion (ranging from $4.4 billion to $33.0 billion) in cost of illness and a loss of 61,000 QALYs (ranging from 19,000 to 145,000 QALYs) per year. Roughly 90 % of this loss is caused by five pathogens: nontyphoidal Salmonella enterica ($3.3 billion; 17,000 QALYs), Campylobacter spp. ($1.7 billion; 13,300 QALYs), Listeria monocytogenes ($2.6 billion; 9,400 QALYs), Toxoplasma gondii ($3 billion; 11,000 QALYs), and norovirus ($2 billion; 5,000 QALYs). A companion article attributes losses estimated in this study to the consumption of specific categories of foods. To arrive at these estimates, for each pathogen we create disease outcome trees that characterize the symptoms, severities, durations, outcomes, and likelihoods of health states associated with that pathogen. We then estimate the cost of illness (medical costs, productivity loss, and valuation of premature mortality) for each pathogen. We also estimate QALY loss for each health state associated with a given pathogen, using the EuroQol 5D scale. Construction of disease outcome trees, outcome-specific cost of illness, and EuroQol 5D scoring are described in greater detail in a second companion article.

  16. 77 FR 75163 - Federal Acquisition Regulation; Information Collection; Contract Funding-Limitation of Costs/Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Regulation; Information Collection; Contract Funding--Limitation of Costs/Funds AGENCIES: Department of... (NASA). ACTION: Notice of request for public comments regarding an extension of an existing OMB...: Submit comments identified by Information Collection 9000- 0074, Contract Funding--Limitation of...

  17. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA clauses for limitation... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Contract Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall insert...

  18. [Cost effective planning of controlled trials with diagnostic instruments of limited reproducibility].

    PubMed

    Krummenauer, F; Förster, G

    1999-06-01

    This paper proposes a simple approach for sample size prediction in controlled diagnostic or clinical trials for group comparison when the diagnostic (imaging) instrument under consideration shows limited reliability and thus calls for taking replicate measurements on each study subject. Using a specified cost function for the overall trial, a cost optimum replication number per subject is predicted, resulting in a cost-optimum predicted group size. This approach results in remarkable cost-effectiveness, as single assessment costs based on the imaging method under consideration only present a small fraction of the overall costs of preparing study subjects for a series of measurement replications by, for example, injection of nuclear or contrast agents.

  19. Capital accumulation, aspiration adjustment, and population growth: limit cycles in an Easterlin-type model.

    PubMed

    Feichtinger, G; Sorger, G

    1990-01-01

    "One of the recent interesting hypotheses of population growth is due to Easterlin who suggests the possibility of self-generating fluctuations in birth numbers. The present paper tries to answer the question whether feedback mechanisms produce persistent oscillations in population growth. A system of two nonlinear differential equations for the per capita capital stock and the aspiration level is studied by a phase portrait analysis. Using the Poincare-Bendixson theorem we derive sufficient conditions for the existence of a stable limit cycle." (SUMMARY IN FRE)

  20. 20 CFR 667.210 - What administrative cost limits apply to Workforce Investment Act title I grants?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INVESTMENT ACT Administrative Rules, Costs and Limitations § 667.210 What administrative cost limits apply to... be identified in the grant or contract award document. (c) In a One-Stop environment,...

  1. Impact of work-related cancers in Taiwan-Estimation with QALY (quality-adjusted life year) and healthcare costs.

    PubMed

    Lee, Lukas Jyuhn-Hsiarn; Lin, Cheng-Kuan; Hung, Mei-Chuan; Wang, Jung-Der

    2016-12-01

    This study estimates the annual numbers of eight work-related cancers, total losses of quality-adjusted life years (QALYs), and lifetime healthcare expenditures that possibly could be saved by improving occupational health in Taiwan. Three databases were interlinked: the Taiwan Cancer Registry, the National Mortality Registry, and the National Health Insurance Research Database. Annual numbers of work-related cancers were estimated based on attributable fractions (AFs) abstracted from a literature review. The survival functions for eight cancers were estimated and extrapolated to lifetime using a semi-parametric method. A convenience sample of 8846 measurements of patients' quality of life with EQ-5D was collected for utility values and multiplied by survival functions to estimate quality-adjusted life expectancies (QALEs). The loss-of-QALE was obtained by subtracting the QALE of cancer from age- and sex-matched referents simulated from national vital statistics. The lifetime healthcare expenditures were estimated by multiplying the survival probability with mean monthly costs paid by the National Health Insurance for cancer diagnosis and treatment and summing this for the expected lifetime. A total of 3010 males and 726 females with eight work-related cancers were estimated in 2010. Among them, lung cancer ranked first in terms of QALY loss, with an annual total loss-of-QALE of 28,463 QALYs and total lifetime healthcare expenditures of US$36.6 million. Successful prevention of eight work-related cancers would not only avoid the occurrence of 3736 cases of cancer, but would also save more than US$70 million in healthcare costs and 46,750 QALYs for the Taiwan society in 2010.

  2. 45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... administration costs. (1) You may provide your share of program operating costs with cash, including other...'s share of program costs? 2521.45 Section 2521.45 Public Welfare Regulations Relating to Public... limitations on the Federal government's share of program costs? The limitations on the Federal...

  3. Plastic Response of Tracheids in Pinus pinaster in a Water-Limited Environment: Adjusting Lumen Size instead of Wall Thickness

    PubMed Central

    Carvalho, Ana; Nabais, Cristina; Vieira, Joana; Rossi, Sergio; Campelo, Filipe

    2015-01-01

    The formation of wood results from cambial activity and its anatomical properties reflect the variability of environmental conditions during the growing season. Recently, it was found that wood density variations in conifers growing under cold-limited environment result from the adjustment of cell wall thickness (CWT) to temperature. Additionally, it is known that intra-annual density fluctuations (IADFs) are formed in response to precipitation after the summer drought. Although IADFs are frequent in Mediterranean conifers no study has yet been conducted to determine if these structures result from the adjustment of lumen diameter (LD) or CWT to soil water availability. Our main objective is to investigate the intra-ring variation of wood anatomical features (LD and CWT) in Pinus pinaster Ait. growing under a water-limited environment. We compared the tracheidograms of LD and CWT for the years 2010–2013 in P. pinaster growing in the west coast of Portugal. Our results suggest a close association between LD and soil moisture content along the growing season, reinforcing the role of water availability in determining tracheid size. Compared with CWT, LD showed a higher intra- and inter-annual variability suggesting its strong adjustment value to variations in water availability. The formation of a latewood IADF appears to be predisposed by higher rates of cell production in spring and triggered by early autumn precipitation. Our findings reinforce the crucial role of water availability on cambial activity and wood formation in Mediterranean conifers, and emphasize the high plasticity of wood anatomical features under Mediterranean climate. PMID:26305893

  4. Plastic Response of Tracheids in Pinus pinaster in a Water-Limited Environment: Adjusting Lumen Size instead of Wall Thickness.

    PubMed

    Carvalho, Ana; Nabais, Cristina; Vieira, Joana; Rossi, Sergio; Campelo, Filipe

    2015-01-01

    The formation of wood results from cambial activity and its anatomical properties reflect the variability of environmental conditions during the growing season. Recently, it was found that wood density variations in conifers growing under cold-limited environment result from the adjustment of cell wall thickness (CWT) to temperature. Additionally, it is known that intra-annual density fluctuations (IADFs) are formed in response to precipitation after the summer drought. Although IADFs are frequent in Mediterranean conifers no study has yet been conducted to determine if these structures result from the adjustment of lumen diameter (LD) or CWT to soil water availability. Our main objective is to investigate the intra-ring variation of wood anatomical features (LD and CWT) in Pinus pinaster Ait. growing under a water-limited environment. We compared the tracheidograms of LD and CWT for the years 2010-2013 in P. pinaster growing in the west coast of Portugal. Our results suggest a close association between LD and soil moisture content along the growing season, reinforcing the role of water availability in determining tracheid size. Compared with CWT, LD showed a higher intra- and inter-annual variability suggesting its strong adjustment value to variations in water availability. The formation of a latewood IADF appears to be predisposed by higher rates of cell production in spring and triggered by early autumn precipitation. Our findings reinforce the crucial role of water availability on cambial activity and wood formation in Mediterranean conifers, and emphasize the high plasticity of wood anatomical features under Mediterranean climate.

  5. Adjustment of growth and central metabolism to a mild but sustained nitrogen-limitation in Arabidopsis.

    PubMed

    Tschoep, Hendrik; Gibon, Yves; Carillo, Petronia; Armengaud, Patrick; Szecowka, Marek; Nunes-Nesi, Adriano; Fernie, Alisdair R; Koehl, Karin; Stitt, Mark

    2009-03-01

    We have established a simple soil-based experimental system that allows a small and sustained restriction of growth of Arabidopsis by low nitrogen (N). Plants were grown in a large volume of a peat-vermiculite mix that contained very low levels of inorganic N. As a control, inorganic N was added in solid form to the peat-vermiculite mix, or plants were grown in conventional nutrient-rich solids. The low N growth regime led to a sustained 20% decrease of the relative growth rate over a period of 2 weeks, resulting in a two- to threefold decrease in biomass in 35- to 40-day-old plants. Plants in the low N regime contained lower levels of nitrate, lower nitrate reductase activity, lower levels of malate, fumarate and other organic acids and slightly higher levels of starch, as expected from published studies of N-limited plants. However, their rosette protein content was unaltered, and total and many individual amino acid levels increased compared with N-replete plants. This metabolic phenotype reveals that Arabidopsis responds adaptively to low N by decreasing the rate of growth, while maintaining the overall protein content, and maintaining or even increasing the levels of many amino acids.

  6. 20 CFR 416.556 - Waiver of adjustment or recovery-countable resources in excess of the limits prescribed in § 416...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... adjustment or recovery will be made, unless the failure to report the value of the excess resources correctly... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Waiver of adjustment or recovery-countable resources in excess of the limits prescribed in § 416.1205 by $50 or less. 416.556 Section...

  7. 34 CFR 658.40 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are the limitations on allowable costs? 658.40 Section 658.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN...

  8. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... approval of self-employment plans. 21.258 Section 21.258 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Vocational Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.258 Cost limitations on approval of...

  9. 20 CFR 641.867 - What are the limitations on the amount of SCSEP administrative costs?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false What are the limitations on the amount of SCSEP administrative costs? 641.867 Section 641.867 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT...

  10. 20 CFR 641.867 - What are the limitations on the amount of SCSEP administrative costs?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false What are the limitations on the amount of SCSEP administrative costs? 641.867 Section 641.867 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT...

  11. 34 CFR 373.22 - What are the limitations on indirect costs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false What are the limitations on indirect costs? 373.22 Section 373.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL DEMONSTRATION PROGRAMS...

  12. 34 CFR 373.22 - What are the limitations on indirect costs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true What are the limitations on indirect costs? 373.22 Section 373.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL DEMONSTRATION PROGRAMS...

  13. 34 CFR 373.22 - What are the limitations on indirect costs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false What are the limitations on indirect costs? 373.22 Section 373.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL DEMONSTRATION PROGRAMS...

  14. 34 CFR 373.22 - What are the limitations on indirect costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What are the limitations on indirect costs? 373.22 Section 373.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL DEMONSTRATION PROGRAMS...

  15. 34 CFR 373.22 - What are the limitations on indirect costs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true What are the limitations on indirect costs? 373.22 Section 373.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL DEMONSTRATION PROGRAMS...

  16. 48 CFR 3452.232-70 - Limitation of cost or funds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Limitation of cost or funds. 3452.232-70 Section 3452.232-70 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions...

  17. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  18. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  19. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  20. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  1. 34 CFR 280.41 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false What are the limitations on allowable costs? 280.41 Section 280.41 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION MAGNET SCHOOLS ASSISTANCE PROGRAM What...

  2. 34 CFR 658.40 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What are the limitations on allowable costs? 658.40 Section 658.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN...

  3. 34 CFR 658.40 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What are the limitations on allowable costs? 658.40 Section 658.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN...

  4. 34 CFR 658.40 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What are the limitations on allowable costs? 658.40 Section 658.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN...

  5. 34 CFR 658.40 - What are the limitations on allowable costs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What are the limitations on allowable costs? 658.40 Section 658.40 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN...

  6. The Impact of Debt Limitations and Referenda Requirements on the Cost of School District Bond Issues

    ERIC Educational Resources Information Center

    Harris, Mary H.; Munley, Vincent G.

    2011-01-01

    One distinction between the markets for corporate and municipal bonds involves institutional constraints that apply to some municipal bond issues. This research focuses on how public finance institutions, in particular explicit debt limits and referenda requirements, affect the borrowing cost of individual school district bond issues. The…

  7. 42 CFR 447.206 - Cost limit for providers operated by units of government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... section applies to payments made to health care providers that are operated by units of government as...) of the Act. (a) General rules. (1) All health care providers that are operated by units of government are limited to reimbursement not in excess of the individual health care provider's cost of...

  8. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  9. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  10. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  11. 48 CFR 1832.705-270 - NASA clauses for limitation of cost or funds.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Funding 1832.705-270 NASA clauses for limitation of cost or funds. (a) The contracting officer shall... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA clauses for... insert a clause substantially as stated at 1852.232-81, Contract Funding, in Section B of...

  12. High thermal tolerance of a rainbow trout population near its southern range limit suggests local thermal adjustment

    PubMed Central

    Verhille, Christine E.; English, Karl K.; Cocherell, Dennis E.; Farrell, Anthony P.; Fangue, Nann A.

    2016-01-01

    Transformation of earth's ecosystems by anthropogenic climate change is predicted for the 21st century. In many regions, the associated increase in environmental temperatures and reduced precipitation will have direct effects on the physiological performance of terrestrial and aquatic ectotherms and have already threatened fish biodiversity and important fisheries. The threat of elevated environmental temperatures is particularly salient for members of the Oncorhynchus genus living in California, which is the southern limit of their range. Here, we report the first assessments of the aerobic capacity of a Californian population of wild Oncorhynchus mykiss Walbaum in relationship to water temperature. Our field measurements revealed that wild O. mykiss from the lower Tuolumne River, California maintained 95% of their peak aerobic scope across an impressive temperature range (17.8–24.6°C). The thermal range for peak performance corresponds to local high river temperatures, but represents an unusually high temperature tolerance compared with conspecifics and congeneric species from northern latitudes. This high thermal tolerance suggests that O. mykiss at the southern limit of their indigenous distribution may be locally adjusted relative to more northern populations. From fisheries management and conservation perspectives, these findings challenge the use of a single thermal criterion to regulate the habitat of the O. mykiss species along the entirety of its distribution range. PMID:27957333

  13. When does female multiple mating evolve to adjust inbreeding? Effects of inbreeding depression, direct costs, mating constraints, and polyandry as a threshold trait

    PubMed Central

    Duthie, A. Bradley; Bocedi, Greta; Reid, Jane M.

    2016-01-01

    Polyandry is often hypothesized to evolve to allow females to adjust the degree to which they inbreed. Multiple factors might affect such evolution, including inbreeding depression, direct costs, constraints on male availability, and the nature of polyandry as a threshold trait. Complex models are required to evaluate when evolution of polyandry to adjust inbreeding is predicted to arise. We used a genetically explicit individual‐based model to track the joint evolution of inbreeding strategy and polyandry defined as a polygenic threshold trait. Evolution of polyandry to avoid inbreeding only occurred given strong inbreeding depression, low direct costs, and severe restrictions on initial versus additional male availability. Evolution of polyandry to prefer inbreeding only occurred given zero inbreeding depression and direct costs, and given similarly severe restrictions on male availability. However, due to its threshold nature, phenotypic polyandry was frequently expressed even when strongly selected against and hence maladaptive. Further, the degree to which females adjusted inbreeding through polyandry was typically very small, and often reflected constraints on male availability rather than adaptive reproductive strategy. Evolution of polyandry solely to adjust inbreeding might consequently be highly restricted in nature, and such evolution cannot necessarily be directly inferred from observed magnitudes of inbreeding adjustment. PMID:27464756

  14. A Low-cost, Off-the-Shelf Ready Field Programmable Gate Array diode Laser Controller With adjustable parameters

    NASA Astrophysics Data System (ADS)

    Yang, Ge; Barry, John. F.; Shuman, Edward; Demille, David

    2010-03-01

    We have constructed a field programmable gate array (FPGA) based lock-in amplifier/PID servo controller for use in laser frequency locking and other applications. Our system is constructed from a commercial FPGA evaluation board with total cost less than 400 and no additional electronic component is required. FPGA technology allows us to implement parallel real-time signal processing with great flexibility. Internal parameters such as the modulation frequency, phase delay, gains and filter time constants, etc. can be changed on the fly within a very wide dynamic range through an iPod-like interface. This system was used to lock a tunable diode laser to an external Fabry Perot cavity with piezo and current feedback. A loop bandwidth of 200 kHz was achieved, limited only by the slow ADCs available on the FPGA board. Further improvements in both hardware and software seem possible, and will be discussed.

  15. Medicare program; schedule of limits on home health agency costs per visit for cost reporting periods beginning on or after July 1, 1991--HCFA. Notice with comment period.

    PubMed

    1991-12-09

    This notice sets forth a revised schedule of limits on home health agency costs that may be paid under the Medicare program. This revised schedule of limits applies to cost reporting periods beginning on or after July 1, 1991. As required by section 4207(d) of the Omnibus Budget Reconciliation Act of 1990 (Pub. L. 101-508), this revised schedule of limits incorporates a blended hospital wage index.

  16. Photosynthesis of temperate Eucalyptus globulus trees outside their native range has limited adjustment to elevated CO2 and climate warming.

    PubMed

    Crous, Kristine Y; Quentin, Audrey G; Lin, Yan-Shih; Medlyn, Belinda E; Williams, David G; Barton, Craig V M; Ellsworth, David S

    2013-12-01

    Eucalyptus species are grown widely outside of their native ranges in plantations on all vegetated continents of the world. We predicted that such a plantation species would show high potential for acclimation of photosynthetic traits across a wide range of growth conditions, including elevated [CO2] and climate warming. To test this prediction, we planted temperate Eucalyptus globulus Labill. seedlings in climate-controlled chambers in the field located >700 km closer to the equator than the nearest natural occurrence of this species. Trees were grown in a complete factorial combination of elevated CO2 concentration (eC; ambient [CO2] +240 ppm) and air warming treatments (eT; ambient +3 °C) for 15 months until they reached ca. 10 m height. There was little acclimation of photosynthetic capacity to eC and hence the CO2-induced photosynthetic enhancement was large (ca. 50%) in this treatment during summer. The warming treatment significantly increased rates of both carboxylation capacity (V(cmax)) and electron transport (Jmax) (measured at a common temperature of 25 °C) during winter, but decreased them significantly by 20-30% in summer. The photosynthetic CO2 compensation point in the absence of dark respiration (Γ*) was relatively less sensitive to temperature in this temperate eucalypt species than for warm-season tobacco. The temperature optima for photosynthesis and Jmax significantly changed by about 6 °C between winter and summer, but without further adjustment from early to late summer. These results suggest that there is an upper limit for the photosynthetic capacity of E. globulus ssp. globulus outside its native range to acclimate to growth temperatures above 25 °C. Limitations to temperature acclimation of photosynthesis in summer may be one factor that defines climate zones where E. globulus plantation productivity can be sustained under anticipated global environmental change.

  17. Medicare program; schedule of limits on home health agency costs per visit for cost reporting periods beginning on or after July 1, 1989--HCFA. Final notice.

    PubMed

    1991-03-28

    This final notice sets forth a revised schedule of limits on home health agency costs that may be paid under the Medicare program. This revised schedule of limits applies to cost reporting periods beginning on or after July 1, 1989 and before July 1, 1991. As required by section 6222 of the Omnibus Budget Reconciliation Act of 1989 (Pub. L. 101-239), the revised schedule of limits incorporates the hospital wage index in effect for cost reporting periods beginning prior to July 1, 1989.

  18. Evaluating the effects of variation in clinical practice: a risk adjusted cost-effectiveness (RAC-E) analysis of acute stroke services

    PubMed Central

    2012-01-01

    Background Methods for the cost-effectiveness analysis of health technologies are now well established, but such methods may also have a useful role in the context of evaluating the effects of variation in applied clinical practice. This study illustrates a general methodology for the comparative analysis of applied clinical practice at alternative institutions – risk adjusted cost-effectiveness (RAC-E) analysis – with an application that compares acute hospital services for stroke patients admitted to the main public hospitals in South Australia. Methods Using linked, routinely collected data on all South Australian hospital separations from July 2001 to June 2008, an analysis of the RAC-E of services provided at four metropolitan hospitals was undertaken using a decision analytic framework. Observed (plus extrapolated) and expected lifetime costs and survival were compared across patient populations, from which the relative cost-effectiveness of services provided at the different hospitals was estimated. Results Unadjusted results showed that at one hospital patients incurred fewer costs and gained more life years than at the other hospitals (i.e. it was the dominant hospital). After risk adjustment, the cost minimizing hospital incurred the lowest costs, but with fewer life-years gained than one other hospital. The mean incremental cost per life-year gained of services provided at the most effective hospital was under $20,000, with an associated 65% probability of being cost-effective at a $50,000 per life year monetary threshold. Conclusions RAC-E analyses can be used to identify important variation in the costs and outcomes associated with clinical practice at alternative institutions. Such data provides an impetus for further investigation to identify specific areas of variation, which may then inform the dissemination of best practice service delivery and organisation. PMID:22905669

  19. 10 CFR 719.32 - For what costs is the contractor, or Department retained counsel, limited to reimbursement of...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false For what costs is the contractor, or Department retained counsel, limited to reimbursement of actual costs only? 719.32 Section 719.32 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS Reimbursement of Costs Subject to This Part § 719.32 For what...

  20. 10 CFR 719.32 - For what costs is the contractor, or Department retained counsel, limited to reimbursement of...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false For what costs is the contractor, or Department retained counsel, limited to reimbursement of actual costs only? 719.32 Section 719.32 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS Reimbursement of Costs Subject to This Part § 719.32 For what...

  1. 10 CFR 719.32 - For what costs is the contractor, or Department retained counsel, limited to reimbursement of...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false For what costs is the contractor, or Department retained counsel, limited to reimbursement of actual costs only? 719.32 Section 719.32 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS Reimbursement of Costs Subject to This Part § 719.32 For what...

  2. Delivering pediatric HIV care in resource-limited settings: cost considerations in an expanded response.

    PubMed

    Tolle, Michael A; Phelps, B Ryan; Desmond, Chris; Sugandhi, Nandita; Omeogu, Chinyere; Jamieson, David; Ahmed, Saeed; Reuben, Elan; Muhe, Lulu; Kellerman, Scott E

    2013-11-01

    If children are to be protected from HIV, the expansion of PMTCT programs must be complemented by increased provision of paediatric treatment. This is expensive, yet there are humanitarian, equity and children's rights arguments to justify the prioritization of treating HIV-infected children. In the context of limited budgets, inefficiencies cost lives, either through lower coverage or less effective services. With the goal of informing the design and expansion of efficient paediatric treatment programs able to utilize to greatest effect the available resources allocated to the treatment of HIV-infected children, this article reviews what is known about cost drivers in paediatric HIV interventions, and makes suggestions for improving efficiency in paediatric HIV programming. High-impact interventions known to deliver disproportional returns on investment are highlighted and targeted for immediate scale-up. Progress will carry a cost - increased funding, as well as additional data on intervention costs and outcomes, will be required if universal access of HIV-infected children to treatment is to be achieved and sustained.

  3. The relationship between effectiveness and costs measured by a risk-adjusted case-mix system: multicentre study of Catalonian population data bases

    PubMed Central

    Sicras-Mainar, Antoni; Navarro-Artieda, Ruth; Blanca-Tamayo, Milagrosa; Velasco-Velasco, Soledad; Escribano-Herranz, Esperanza; Llopart-López, Josep Ramon; Violan-Fors, Concepción; Vilaseca-Llobet, Josep Maria; Sánchez-Fontcuberta, Encarna; Benavent-Areu, Jaume; Flor-Serra, Ferran; Aguado-Jodar, Alba; Rodríguez-López, Daniel; Prados-Torres, Alejandra; Estelrich-Bennasar, Jose

    2009-01-01

    Background The main objective of this study is to measure the relationship between morbidity, direct health care costs and the degree of clinical effectiveness (resolution) of health centres and health professionals by the retrospective application of Adjusted Clinical Groups in a Spanish population setting. The secondary objectives are to determine the factors determining inadequate correlations and the opinion of health professionals on these instruments. Methods/Design We will carry out a multi-centre, retrospective study using patient records from 15 primary health care centres and population data bases. The main measurements will be: general variables (age and sex, centre, service [family medicine, paediatrics], and medical unit), dependent variables (mean number of visits, episodes and direct costs), co-morbidity (Johns Hopkins University Adjusted Clinical Groups Case-Mix System) and effectiveness. The totality of centres/patients will be considered as the standard for comparison. The efficiency index for visits, tests (laboratory, radiology, others), referrals, pharmaceutical prescriptions and total will be calculated as the ratio: observed variables/variables expected by indirect standardization. The model of cost/patient/year will differentiate fixed/semi-fixed (visits) costs of the variables for each patient attended/year (N = 350,000 inhabitants). The mean relative weights of the cost of care will be obtained. The effectiveness will be measured using a set of 50 indicators of process, efficiency and/or health results, and an adjusted synthetic index will be constructed (method: percentile 50). The correlation between the efficiency (relative-weights) and synthetic (by centre and physician) indices will be established using the coefficient of determination. The opinion/degree of acceptance of physicians (N = 1,000) will be measured using a structured questionnaire including various dimensions. Statistical analysis: multiple regression analysis (procedure

  4. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE... 45 Public Welfare 4 2010-10-01 2010-10-01 false Limitations on costs of development and... and General Administration § 1301.32 Limitations on costs of development and administration of a...

  5. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE... 45 Public Welfare 4 2012-10-01 2012-10-01 false Limitations on costs of development and... and General Administration § 1301.32 Limitations on costs of development and administration of a...

  6. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE... 45 Public Welfare 4 2011-10-01 2011-10-01 false Limitations on costs of development and... and General Administration § 1301.32 Limitations on costs of development and administration of a...

  7. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE... 45 Public Welfare 4 2013-10-01 2013-10-01 false Limitations on costs of development and... and General Administration § 1301.32 Limitations on costs of development and administration of a...

  8. 45 CFR 1301.32 - Limitations on costs of development and administration of a Head Start program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE... 45 Public Welfare 4 2014-10-01 2014-10-01 false Limitations on costs of development and... and General Administration § 1301.32 Limitations on costs of development and administration of a...

  9. The Role of Inflation and Price Escalation Adjustments in Properly Estimating Program Costs: F-35 Case Study

    DTIC Science & Technology

    2016-03-01

    First, the analyst must use a price index when normalizing historical cost data to a common point in time (where the normalized costs are referred to...escalation in the historical period. We demonstrate the effect of different escalation methodologies using top-level CER models. Cost analysts usually...both normalizing historical data and making projections, are also valid in more typical cost estimating applications. For example, escalation rates for

  10. Cost-appropriateness of whole body vs limited bone imaging for suspected focal sports injuries

    SciTech Connect

    Nagle, C.E.

    1986-07-01

    Bone imaging has been recognized as a useful diagnostic tool in detecting the presence of focal musculoskeletal injury when radiographs are normal. A retrospective review of bone images in a small number of amateur athletes indicates that secondary injuries were commonly detected at sites different from the site of musculoskeletal pain being evaluated for injury. While a larger study will be necessary to confirm the data, this review suggests that it is medically justified and cost-appropriate to perform imaging of the entire skeleton as opposed to imaging limited to the anatomic site of pain and suspected injury.

  11. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR... tracking, data entry and monitoring, including personnel and other costs associated with the...

  12. Limited applicability of cost-effectiveness and cost-benefit analyses for the optimization of radon remedial measures.

    PubMed

    Jiránek, Martin; Rovenská, Katerina

    2010-10-15

    Ways of using different decision-aiding techniques for optimizing and evaluating radon remedial measures have been studied on a large set of data obtained from the remediation of 32 houses that had an original indoor radon level above 1000 Bq/m(3). Detailed information about radon concentrations before and after remediation, type of remedial measures and installation and operation costs were used as the input parameters for a comparison of costs and for determining the efficiencies, for a cost-benefit analysis and a cost-effectiveness analysis, in order to find out whether these criteria and techniques provide sufficient and relevant information for improving and optimizing remediation. Our study confirmed that the installation costs of remediation do not depend on the original indoor radon level, but on the technical state of the building. In addition, the study reveals that the efficiency of remediation does not depend on the installation costs. Cost-benefit analysis and cost-effectiveness analysis lead to the conclusion that remedial measures reducing the indoor radon concentration from values above 1000 Bq/m(3) are always acceptable and reasonable. On the other hand, these techniques can neither help the designer to choose the proper remedial measure nor provide information resulting in improved remediation.

  13. Initial investigation into lower-cost CT for resource limited regions of the world

    NASA Astrophysics Data System (ADS)

    Dobbins, James T., III; Wells, Jered R.; Segars, W. Paul; Li, Christina M.; Kigongo, Christopher J. N.

    2010-04-01

    This paper describes an initial investigation into means for producing lower-cost CT scanners for resource limited regions of the world. In regions such as sub-Saharan Africa, intermediate level medical facilities serving millions have no CT machines, and lack the imaging resources necessary to determine whether certain patients would benefit from being transferred to a hospital in a larger city for further diagnostic workup or treatment. Low-cost CT scanners would potentially be of immense help to the healthcare system in such regions. Such scanners would not produce state-of-theart image quality, but rather would be intended primarily for triaging purposes to determine the patients who would benefit from transfer to larger hospitals. The lower-cost scanner investigated here consists of a fixed digital radiography system and a rotating patient stage. This paper describes initial experiments to determine if such a configuration is feasible. Experiments were conducted using (1) x-ray image acquisition, a physical anthropomorphic chest phantom, and a flat-panel detector system, and (2) a computer-simulated XCAT chest phantom. Both the physical phantom and simulated phantom produced excellent image quality reconstructions when the phantom was perfectly aligned during acquisition, but artifacts were noted when the phantom was displaced to simulate patient motion. An algorithm was developed to correct for motion of the phantom and demonstrated success in correcting for 5-mm motion during 360-degree acquisition of images. These experiments demonstrated feasibility for this approach, but additional work is required to determine the exact limitations produced by patient motion.

  14. 75 FR 49411 - Consumer Price Index Adjustments of Oil Pollution Act of 1990 Limits of Liability-Vessels and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... Number 1625-0046 entitled ``Financial Responsibility for Water Pollution (Vessels).'' The approval for... SECURITY Coast Guard 33 CFR Part 138 RIN 1625-AB25 Consumer Price Index Adjustments of Oil Pollution Act of...; information collection approval. SUMMARY: On July 1, 2009, the Coast Guard amended the Oil Pollution Act...

  15. Medicare program; schedule of limits on home health agency costs per visit--HCFA. Notice with comment period.

    PubMed

    1995-02-14

    This notice with comment period sets forth a revised schedule of limits on home health agency costs that may be paid under the Medicare program for cost reporting periods beginning on or after July 1, 1993. These limits replace the per-visit limits that were set forth in our July 8, 1993 notice with comment period (58 FR 36748). This notice also provides, in accordance with the provisions of the Omnibus Budget Reconciliation Act of 1993 (OBRA '93), that there will be no changes in the home health agency (HHA) cost limits for cost reporting periods beginning on or after July 1, 1994, and before July 1, 1996. In addition, this notice responds to public comments on the July 8, 1993 notice with comment period, which originally set forth the HHA cost limits for cost reporting periods beginning on or after July 1, 1993, and on the January 6, 1994 notice with comment period (59 FR 760), which announced the elimination of the hospital based add-on effective for cost reporting periods beginning on or after October 1, 1993.

  16. The Medicare Cost Report and the limits of hospital accountability: improving financial accounting data.

    PubMed

    Kane, N M; Magnus, S A

    2001-02-01

    Health policy makers, legislators, providers, payers, and a broad range of other players in the health care market routinely seek information on hospital financial performance. Yet the data at their disposal are limited, especially since hospitals' audited financial statements--the "gold standard" in hospital financial reporting--are not publicly available in many states. As a result, the Medicare Cost Report (MCR), filed annually by most U.S. hospitals in order to receive payment for treating Medicare patients, has become the primary public source of hospital financial information. However, financial accounting elements in the MCR are unreliable, poorly defined, and lacking in critical detail. Comparative analyses of MCRs and matched, audited financial statements reveal long-standing problems with the MCR's data, including major differences in reported profits; variations in the reporting of both revenues and expenses; an absence of relevant details, such as charity care, bad debt, operating versus nonoperating income, and affiliate transactions; an inconsistent classification of changes in net assets; and a failure to provide cash flow statements. Because of these problems, MCR financial data give only a limited and often inaccurate picture of the financial position of hospitals. Audited financial statements provide a more complete perspective, enabling analysts to address important questions left unanswered by the MCR data. Regulatory action is needed to create a national database of financial information based upon audited statements.

  17. Low-cost assays for monitoring HIV infected individuals in resource-limited settings

    PubMed Central

    Balakrishnan, Pachamuthu; Iqbal, Hussain Syed; Shanmugham, Saravanan; Mohanakrishnan, Janardhanan; Solomon, Sunil S.; Mayer, Kenneth H.; Solomon, Suniti

    2011-01-01

    Use of a combination of CD4 counts and HIV viral load testing in the management of antiretroviral therapy (ART) provides higher prognostic estimation of the risk of disease progression than does the use of either test alone. The standard methods to monitor HIV infection are flow cytometry based for CD4+ T cell count and molecular assays to quantify plasma viral load of HIV. Commercial assays have been routinely used in developed countries to monitor ART. However, these assays require expensive equipment and reagents, well trained operators, and established laboratory infrastructure. These requirements restrict their use in resource-limited settings where people are most afflicted with the HIV-1 epidemic. With the advent of low-cost and/or low-tech alternatives, the possibility of implementing CD4 count and viral load testing in the management of ART in resource-limited settings is increasing. However, an appropriate validation should have been done before putting them to use for patient testing. PMID:22310816

  18. Dynamically Adjustable Wind Turbine Blades: Adaptive Turbine Blades, Blown Wing Technology for Low-Cost Wind Power

    SciTech Connect

    2010-02-02

    Broad Funding Opportunity Announcement Project: Caitin is developing wind turbines with a control system that delivers compressed air from special slots located in the surface of its blades. The compressed air dynamically adjusts the aerodynamic performance of the blades, and can essentially be used to control lift, drag, and ultimately power. This control system has been shown to exhibit high levels of control in combination with an exceptionally fast response rate. The deployment of such a control system in modern wind turbines would lead to better management of the load on the system during peak usage, allowing larger blades to be deployed with a resulting increase in energy production.

  19. Cost-effectiveness of chemotherapy combined with thoracic radiotherapy versus chemotherapy alone for limited stage small cell lung cancer: A population-based propensity-score matched analysis

    PubMed Central

    Chien, Chun-Ru; Hsia, Te-Chun; Chen, Chih-Yi

    2014-01-01

    Background The addition of thoracic radiotherapy improves the outcome of limited stage small cell lung cancer (LS-SCLC), however, the cost-effectiveness of this process has never been reported. We aimed to estimate the short-term cost-effectiveness of chemotherapy combined with thoracic radiotherapy (C-TRT) versus chemotherapy alone (C/T) for LS-SCLC patients from the payer's perspective (Taiwan National Health Insurance). Methods We identified LS-SCLC patients diagnosed within 2007–2009 through a comprehensive population-based database containing cancer and death registries, and reimbursement data. The duration of interest was one year within diagnosis. We included potential confounding covariables through literature searching and our own experience, and used a propensity score to construct a 1:1 population for adjustment. We used a net benefit (NB) approach to evaluate the cost-effectiveness at various willingness-to-pay (WTP) levels. Sensitivity analysis regarding potential unmeasured confounder(s) was performed. Results Our study population constituted 74 patients. The mean cost (2013 USD) and survival (year) was higher for C-TRT (42 439 vs. 28 357; 0.94 vs. 0.88). At the common WTP level (50 000 USD/life-year), C-TRT was not cost effective (incremental NB − 11 082) and the probability for C-TRT to be cost effective (i.e. positive net benefit) was 0.005. The result was moderately sensitive to potential unmeasured confounder(s) in sensitivity analysis. Conclusions We provide evidence that when compared to C/T, C-TRT is effective in improving survival, but is not cost-effective in the short-term at a common WTP level from a payer's perspective. This information should be considered by clinicians when discussing thoracic radiotherapy with their LS-SCLC patients. PMID:26767048

  20. The Costs of Delivering Integrated HIV and Sexual Reproductive Health Services in Limited Resource Settings

    PubMed Central

    Obure, Carol Dayo; Sweeney, Sedona; Darsamo, Vanessa; Michaels-Igbokwe, Christine; Guinness, Lorna; Terris-Prestholt, Fern; Muketo, Esther; Nhlabatsi, Zelda; Warren, Charlotte E.; Mayhew, Susannah; Watts, Charlotte; Vassall, Anna

    2015-01-01

    Objective To present evidence on the total costs and unit costs of delivering six integrated sexual reproductive health and HIV services in a high and medium HIV prevalence setting, in order to support policy makers and planners scaling up these essential services. Design A retrospective facility based costing study conducted in 40 non-government organization and public health facilities in Kenya and Swaziland. Methods Economic and financial costs were collected retrospectively for the year 2010/11, from each study site with an aim to estimate the cost per visit of six integrated HIV and SRH services. A full cost analysis using a combination of bottom-up and step-down costing methods was conducted from the health provider’s perspective. The main unit of analysis is the economic unit cost per visit for each service. Costs are converted to 2013 International dollars. Results The mean cost per visit for the HIV/SRH services ranged from $Int 14.23 (PNC visit) to $Int 74.21 (HIV treatment visit). We found considerable variation in the unit costs per visit across settings with family planning services exhibiting the least variation ($Int 6.71-52.24) and STI treatment and HIV treatment visits exhibiting the highest variation in unit cost ranging from ($Int 5.44-281.85) and ($Int 0.83-314.95), respectively. Unit costs of visits were driven by fixed costs while variability in visit costs across facilities was explained mainly by technology used and service maturity. Conclusion For all services, variability in unit costs and cost components suggest that potential exists to reduce costs through better use of both human and capital resources, despite the high proportion of expenditure on drugs and medical supplies. Further work is required to explore the key drivers of efficiency and interventions that may facilitate efficiency improvements. PMID:25933414

  1. Risk-adjusted capitation based on the Diagnostic Cost Group Model: an empirical evaluation with health survey information.

    PubMed Central

    Lamers, L M

    1999-01-01

    OBJECTIVE: To evaluate the predictive accuracy of the Diagnostic Cost Group (DCG) model using health survey information. DATA SOURCES/STUDY SETTING: Longitudinal data collected for a sample of members of a Dutch sickness fund. In the Netherlands the sickness funds provide compulsory health insurance coverage for the 60 percent of the population in the lowest income brackets. STUDY DESIGN: A demographic model and DCG capitation models are estimated by means of ordinary least squares, with an individual's annual healthcare expenditures in 1994 as the dependent variable. For subgroups based on health survey information, costs predicted by the models are compared with actual costs. Using stepwise regression procedures a subset of relevant survey variables that could improve the predictive accuracy of the three-year DCG model was identified. Capitation models were extended with these variables. DATA COLLECTION/EXTRACTION METHODS: For the empirical analysis, panel data of sickness fund members were used that contained demographic information, annual healthcare expenditures, and diagnostic information from hospitalizations for each member. In 1993, a mailed health survey was conducted among a random sample of 15,000 persons in the panel data set, with a 70 percent response rate. PRINCIPAL FINDINGS: The predictive accuracy of the demographic model improves when it is extended with diagnostic information from prior hospitalizations (DCGs). A subset of survey variables further improves the predictive accuracy of the DCG capitation models. The predictable profits and losses based on survey information for the DCG models are smaller than for the demographic model. Most persons with predictable losses based on health survey information were not hospitalized in the preceding year. CONCLUSIONS: The use of diagnostic information from prior hospitalizations is a promising option for improving the demographic capitation payment formula. This study suggests that diagnostic

  2. Cost-effectiveness analysis of dialysis and kidney transplant in patients with renal impairment using disability adjusted life years in Iran

    PubMed Central

    YaghoubiFard, Safiye; Goudarzi, Reza; Etminan, Abbas; Baneshi, MohammadReza; Barouni, Mohsen; Jafari Sirizi, Mohammad

    2016-01-01

    Background: This cross-sectional study was conducted to compare the cost-effectiveness of three therapeutic methods of long-term hemodialysis, kidney transplant from a living person and kidney transplant from a cadaver utilizing Disability Adjusted Life Years (DALY) using data from the records of patients referred to Afzalipour Hospital of Kerman in 2012. Methods: This cross-sectional study utilizing Disability Adjusted Life Years (DALY) as outcome measure, used data from the records of patients referred to Afzalipour Hospital of Kerman in 2012. The decision tree model and decision tree software (Tree Age pro 11) were used for data analysis. In this research, costs and effects were studied from the patients and healthcare providers’ perspective. Results: In the patient’s perspective, the CER of dialysis was 5.04 times greater than transplant from a living person and 6.15 times higher than transplant from a cadaveric donor. In the hospital’s perspective, the average cost-effectiveness ratio of dialysis was 8.4 times greater than transplant from a living person and 14.07 times higher than transplant from a cadaver. The smaller the C-E ratio, the greater was the cost-effectiveness. In both perspectives, the order of effectiveness of treatment methods were transplant from a cadaver, transplant from a living person and dialysis. Conclusion: Considering the results obtained in this study, measures should be taken to increase the desire for organ donation from brain-dead patients, living people and patients’ relatives PMID:27493934

  3. Costs of mating competition limit male lifetime breeding success in polygynous mammals

    PubMed Central

    Lukas, Dieter; Clutton-Brock, Tim

    2014-01-01

    Although differences in breeding lifespan are an important source of variation in male fitness, the factors affecting the breeding tenure of males have seldom been explored. Here, we use cross-species comparisons to investigate the correlates of breeding lifespan in male mammals. Our results show that male breeding lifespan depends on the extent of polygyny, which reflects the relative intensity of competition for access to females. Males have relatively short breeding tenure in species where individuals have the potential to monopolize mating with multiple females, and longer ones where individuals defend one female at a time. Male breeding tenure is also shorter in species in which females breed frequently than in those where females breed less frequently, suggesting that the costs of guarding females may contribute to limiting tenure length. As a consequence of these relationships, estimates of skew in male breeding success within seasons overestimate skew calculated across the lifetime and, in several polygynous species, variance in lifetime breeding success is not substantially higher in males than in females. PMID:24827443

  4. Costs of mating competition limit male lifetime breeding success in polygynous mammals.

    PubMed

    Lukas, Dieter; Clutton-Brock, Tim

    2014-07-07

    Although differences in breeding lifespan are an important source of variation in male fitness, the factors affecting the breeding tenure of males have seldom been explored. Here, we use cross-species comparisons to investigate the correlates of breeding lifespan in male mammals. Our results show that male breeding lifespan depends on the extent of polygyny, which reflects the relative intensity of competition for access to females. Males have relatively short breeding tenure in species where individuals have the potential to monopolize mating with multiple females, and longer ones where individuals defend one female at a time. Male breeding tenure is also shorter in species in which females breed frequently than in those where females breed less frequently, suggesting that the costs of guarding females may contribute to limiting tenure length. As a consequence of these relationships, estimates of skew in male breeding success within seasons overestimate skew calculated across the lifetime and, in several polygynous species, variance in lifetime breeding success is not substantially higher in males than in females.

  5. The hidden cost of low prices: limited access to new drugs in India.

    PubMed

    Berndt, Ernst R; Cockburn, Iain M

    2014-09-01

    The pricing and accessibility of patent-protected drugs in low- and middle-income countries is a contentious issue in the global context. But questions about price have little meaning if a drug is not available for purchase, and the extent to which patent policy affects when (and if) new drugs become available in these countries has largely been overlooked. We examined data on the sales of 184 drugs approved by the US Food and Drug Administration between 2000 and 2009. We found that 50 percent of those 184 drugs went on sale in India only after lags of more than five years from their first worldwide introduction. More than half of the drugs that became newly available in India during the study period were produced and sold by multiple manufacturers in the country within one year of their introduction. The presence of multiple manufacturers indicates sharp competition and weak patent protection--factors that are disincentives to manufacturers to incur the costs of gaining access to the market. We conclude that modest patent and regulatory reform could bring the faster availability of a wider range of new drugs in India with limited impact on prices--a trade-off that merits greater policy attention.

  6. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL TANF PROVISIONS Tribal TANF Funding... subject to the limit determined under § 286.50. (b) Information technology and computerization for..., administering, monitoring, and controlling a sample are not inherent parts of information technology...

  7. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL TANF PROVISIONS Tribal TANF Funding... subject to the limit determined under § 286.50. (b) Information technology and computerization for..., administering, monitoring, and controlling a sample are not inherent parts of information technology...

  8. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL TANF PROVISIONS Tribal TANF Funding... subject to the limit determined under § 286.50. (b) Information technology and computerization for..., administering, monitoring, and controlling a sample are not inherent parts of information technology...

  9. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL TANF PROVISIONS Tribal TANF Funding... subject to the limit determined under § 286.50. (b) Information technology and computerization for..., administering, monitoring, and controlling a sample are not inherent parts of information technology...

  10. Adaptive capacity of the Adjusted Clinical Groups Case-Mix System to the cost of primary healthcare in Catalonia (Spain): a observational study

    PubMed Central

    Velasco-Velasco, Soledad; Navarro-Artieda, Ruth; Prados-Torres, Alexandra; Bolibar-Ribas, Buenaventura; Violan-Fors, Concepción

    2012-01-01

    Objectives To describe the adaptive capacity of the Adjusted Clinical Groups (ACG) system to the cost of care in primary healthcare centres in Catalonia (Spain). Design Retrospective study (multicentres) conducted using computerised medical records. Setting 13 primary care teams in 2008 were included. Participants All patients registered in the study centres who required care between 1 January and 31 December 2008 were finally studied. Patients not registered in the study centres during the study period were excluded. Outcome measures Demographic (age and sex), dependent (cost of care) and case-mix variables were studied. The cost model for each patient was established by differentiating the fixed and variable costs. To evaluate the adaptive capacity of the ACG system, Pearson's coefficient of variation and the percentage of outliers were calculated. To evaluate the explanatory power of the ACG system, the authors used the coefficient of determination (R2). Results The number of patients studied was 227 235 (frequency: 5.9 visits per person per year), with a mean of 4.5 (3.2) episodes and 8.1 (8.2) visits per patient per year. The mean total cost was €654.2. The explanatory power of the ACG system was 36.9% for costs (56.5% without outliers). 10 ACG categories accounted for 60.1% of all cases and 19 for 80.9%. 5 categories represented 71% of poor performance (N=78 887, 34.7%), particularly category 0300-Acute Minor, Age 6+ (N=26 909, 11.8%), which had a coefficient of variation =139% and 6.6% of outliers. Conclusions The ACG system is an appropriate manner of classifying patients in routine clinical practice in primary healthcare centres in Catalonia, although improvements to the adaptive capacity through disaggregation of some categories according to age groups and, especially, the number of acute episodes in paediatric patients would be necessary to reduce intra-group variation. PMID:22734115

  11. A limit-cycle model of leg movements in cross-country skiing and its adjustments with fatigue.

    PubMed

    Cignetti, F; Schena, F; Mottet, D; Rouard, A

    2010-08-01

    Using dynamical modeling tools, the aim of the study was to establish a minimal model reproducing leg movements in cross-country skiing, and to evaluate the eventual adjustments of this model with fatigue. The participants (N=8) skied on a treadmill at 90% of their maximal oxygen consumption, up to exhaustion, using the diagonal stride technique. Qualitative analysis of leg kinematics portrayed in phase planes, Hooke planes, and velocity profiles suggested the inclusion in the model of a linear stiffness and an asymmetric van der Pol-type nonlinear damping. Quantitative analysis revealed that this model reproduced the observed kinematics patterns of the leg with adequacy, accounting for 87% of the variance. A rising influence of the stiffness term and a dropping influence of the damping terms were also evidenced with fatigue. The meaning of these changes was discussed in the framework of motor control.

  12. Inclusion of costs in conservation planning depends on limited datasets and hopeful assumptions.

    PubMed

    Armsworth, Paul R

    2014-08-01

    Many conservation organizations use spatial prioritization to help identify locations in which to work. Increasingly, prioritizations seek to account for spatial heterogeneity in the costs of conservation, motivated in part by claims of large efficiency savings when these costs are included. I critically review the cost estimates on which such claims are based, focusing on acquisition and management costs associated with terrestrial protected areas. If researchers are to evaluate how including costs affects conservation planning outcomes, estimation methods need to preserve the covariation between and relative variation within costs and benefits of conservation activities. However, widely used methods for estimating costs and incorporating them into prioritizations may not meet these standards. For example, among relevant studies, there is surprisingly little attention given to the costs that conservation organizations actually face. Instead, there is a heavy reliance on untested proxies for conservation costs. Analytical shortcuts are also common. Now that debate is moving beyond whether to account for costs in conservation planning, it is time to evaluate just how we can include them to greatest effect.

  13. 75 FR 750 - Consumer Price Index Adjustments of Oil Pollution Act of 1990 Limits of Liability-Vessels and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-06

    ... ADDRESSES. List of Subjects in 33 CFR Part 138 Hazardous materials transportation, Insurance, Limits of... of Management and Budget (OMB). ADDRESSES: Comments and material received from the public, as well as... (M-30), U.S. Department of Transportation, West Building Ground Floor, Room W12-140, 1200 New...

  14. 20 CFR 641.876 - How will compliance with cost limitations and minimum expenditure levels be determined?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false How will compliance with cost limitations and minimum expenditure levels be determined? 641.876 Section 641.876 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE...

  15. 20 CFR 641.876 - How will compliance with cost limitations and minimum expenditure levels be determined?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false How will compliance with cost limitations and minimum expenditure levels be determined? 641.876 Section 641.876 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE...

  16. 26 CFR 1.1059A-1 - Limitation on taxpayer's basis or inventory cost in property imported from related persons.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... any way the authority of the Commissioner to increase or decrease the claimed basis or inventory cost... liquidated upon importation, the section 1059A limitation on the undervalued article may be increased up to... increased by the amount of the duty over-paid on Article B, $.20, times 1/.10, up to the amount of...

  17. Limiter

    DOEpatents

    Cohen, S.A.; Hosea, J.C.; Timberlake, J.R.

    1984-10-19

    A limiter with a specially contoured front face is provided. The front face of the limiter (the plasma-side face) is flat with a central indentation. In addition, the limiter shape is cylindrically symmetric so that the limiter can be rotated for greater heat distribution. This limiter shape accommodates the various power scrape-off distances lambda p, which depend on the parallel velocity, V/sub parallel/, of the impacting particles.

  18. 48 CFR 30.606 - Resolving cost impacts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... contract cost ceilings or target costs on flexibly-priced contracts. In such cases, the CFAO shall limit... costs on flexibly-priced contracts. In such cases, the CFAO shall limit any upward contract price...-priced contracts. In such cases, the CFAO shall limit any upward contract price adjustments to...

  19. Limiter

    DOEpatents

    Cohen, Samuel A.; Hosea, Joel C.; Timberlake, John R.

    1986-01-01

    A limiter with a specially contoured front face accommodates the various power scrape-off distances .lambda..sub.p, which depend on the parallel velocity, V.sub..parallel., of the impacting particles. The front face of the limiter (the plasma-side face) is flat with a central indentation. In addition, the limiter shape is cylindrically symmetric so that the limiter can be rotated for greater heat distribution.

  20. Simple and cost-effective fabrication of solid biodegradable polymer microneedle arrays with adjustable aspect ratio for transdermal drug delivery using acupuncture microneedles

    NASA Astrophysics Data System (ADS)

    Cha, Kyoung Je; Kim, Taewan; Jea Park, Sung; Kim, Dong Sung

    2014-11-01

    Polymer microneedle arrays (MNAs) have received much attention for their use in transdermal drug delivery and microneedle therapy systems due to the advantages they offer, such as low cost, good mechanical properties, and a versatile choice of materials. Here, we present a simple and cost-effective method for the fabrication of a biodegradable polymer MNA in which the aspect ratio of each microneedle is adjustable using commercially available acupuncture microneedles. In our process, a master template with acupuncture microneedles, whose shape will be the final MNA, was carefully prepared by fixing them onto a plastic substrate with selectively drilled holes which, in turn, determine the aspect ratios of the microneedles. A polylactic acid (PLA; a biodegradable polymer) MNA was fabricated by a micromolding process with a polydimethylsiloxane (PDMS) mold containing the cavity of the microneedles, which was obtained by the PDMS replica molding against the master template. The mechanical force and degradation behavior of the replicated PLA MNA were characterized with the help of a compression test and an accelerated degradation test, respectively. Finally, the transdermal drug delivery performance of the PLA MNA was successfully simulated by two different methods of penetration and staining, using the skin of a pig cadaver. These results indicated that the proposed method can be effectively used for the fabrication of polymer MNAs which can be used in various microneedle applications.

  1. The Benefits, Limitations, and Cost-Effectiveness of Advanced Technologies in the Management of Patients With Diabetes Mellitus

    PubMed Central

    Vigersky, Robert A.

    2015-01-01

    Background: Hypoglycemia mitigation is critical for appropriately managing patients with diabetes. Advanced technologies are becoming more prevalent in diabetes management, but their benefits have been primarily judged on the basis of hemoglobin A1c. A critical appraisal of the effectiveness and limitations of advanced technologies in reducing both A1c and hypoglycemia rates has not been previously performed. Methods: The cost of hypoglycemia was estimated using literature rates of hypoglycemia events resulting in hospitalizations. A literature search was conducted on the effect on A1c and hypoglycemia of advanced technologies. The cost-effectiveness of continuous subcutaneous insulin infusion (CSII) and real-time continuous glucose monitors (RT-CGM) was reviewed. Results: Severe hypoglycemia in insulin-using patients with diabetes costs $4.9-$12.7 billion. CSII reduces A1c in some but not all studies. CSII improves hypoglycemia in patients with high baseline rates. Bolus calculators improve A1c and improve the fear of hypoglycemia but not hypoglycemia rates. RT-CGM alone and when combined with CSII improve A1c with a neutral effect on hypoglycemia rates. Low-glucose threshold suspend systems reduce hypoglycemia with a neutral effect on A1c, and low-glucose predictive suspend systems reduce hypoglycemia with a small increase in plasma glucose levels. In short-term studies, artificial pancreas systems reduce both hypoglycemia rates and plasma glucose levels. CSII and RT-CGM are cost-effective technologies, but their wide adoption is limited by cost, psychosocial, and educational factors. Conclusions: Most currently available technologies improve A1c with a neutral or improved rate of hypoglycemia. Advanced technologies appear to be cost-effective in diabetes management, especially when including the underlying cost of hypoglycemia. PMID:25555391

  2. 38 CFR 21.258 - Cost limitations on approval of self-employment plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... approved by the VR&E Officer with jurisdiction. Any self-employment plan with an estimated or actual cost of $25,000 or more must be approved by the Director, VR&E Service. (Authority: 38 U.S.C....

  3. Limited encoding of effort by dopamine neurons in a cost-benefit trade-off task

    PubMed Central

    Pasquereau, Benjamin; Turner, Robert S.

    2013-01-01

    Animals are thought to evaluate the desirability of action options using a unified scale that combines predicted benefits (“rewards”), costs, and the animal’s internal motivational state. Midbrain dopamine neurons have long been associated with the reward part of this equation, but it is unclear whether these neurons also estimate the costs of taking an action. We studied the spiking activity of dopamine neurons in the substantia nigra pars compacta of monkeys (Macaca mulatta) during a reaching task in which the energetic costs incurred (friction loads) and the benefits gained (drops of food) were manipulated independently. Although the majority of dopamine neurons encoded the upcoming reward alone, a subset predicted net utility of a course of action by signaling the expected reward magnitude, discounted by the invested cost in terms of physical effort. In addition, the tonic activity of some dopamine neurons was slowly reduced in conjunction with the accumulated trials, which is consistent with the hypothesized role for tonic dopamine in the invigoration or motivation of instrumental responding. The present results shed light on an oft-hypothesized role for dopamine in the regulation of the balance in natural behaviors between the energy expended and the benefits gained, which could explain why dopamine disorders, such as Parkinson’s disease, lead to a breakdown of that balance. PMID:23658169

  4. Local Property Tax Limitations vs. School District Employee Pension Costs in Pennsylvania

    ERIC Educational Resources Information Center

    Hartman, William T.; Shrom, Timothy J.

    2014-01-01

    In Pennsylvania as in many other states, employee pension costs are a significant source of financial pressure for school districts (Zeehandelaar and Northern 2013, Pennsylvania Public Employees' Retirement Commission 2013). In order to gain greater insight into the nature of Pennsylvania school districts' financial burden related to pension…

  5. 40 CFR 35.925-18 - Limitation upon project costs incurred prior to award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works... authorized for step 1 or step 2 project work performed before award of a step 1 or step 2 grant. However... project costs in the following cases: (1) Step 1 work begun after the date of approval by the...

  6. 40 CFR 35.925-18 - Limitation upon project costs incurred prior to award.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... project costs in the following cases: (1) Step 1 work begun after the date of approval by the Regional Administrator of a plan of study, if the State requests and the Regional Administrator has reserved funds for..., 1975, in accordance with an approved plan of study or an approved facilities plan, as appropriate,...

  7. Scope-of-practice laws for nurse practitioners limit cost savings that can be achieved in retail clinics.

    PubMed

    Spetz, Joanne; Parente, Stephen T; Town, Robert J; Bazarko, Dawn

    2013-11-01

    Retail clinics have the potential to reduce health spending by offering convenient, low-cost access to basic health care services. Retail clinics are often staffed by nurse practitioners (NPs), whose services are regulated by state scope-of-practice regulations. By limiting NPs' work scope, restrictive regulations could affect possible cost savings. Using multistate insurance claims data from 2004-07, a period in which many retail clinics opened, we analyzed whether the cost per episode associated with the use of retail clinics was lower in states where NPs are allowed to practice independently and to prescribe independently. We also examined whether retail clinic use and scope of practice were associated with emergency department visits and hospitalizations. We found that visits to retail clinics were associated with lower costs per episode, compared to episodes of care that did not begin with a retail clinic visit, and the costs were even lower when NPs practiced independently. Eliminating restrictions on NPs' scope of practice could have a large impact on the cost savings that can be achieved by retail clinics.

  8. Shared networks of interpreter services, at relatively low cost, can help providers serve patients with limited english skills.

    PubMed

    Jacobs, Elizabeth A; Leos, Ginelle Sanchez; Rathouz, Paul J; Fu, Paul

    2011-10-01

    Language barriers in health care-a large and growing problem in the United States-contribute to disparities in health care quality and outcomes in populations with limited English proficiency. Providing access to adequate interpreter services has been shown to reduce health disparities in these populations. However, many health care organizations do not provide such services because of the perceived high cost. In this observational study we calculated the costs incurred by a group of California public hospitals that formed a network to make trained interpreters available via videoconference and telephone. We found that encounters in this network where interpreters helped patients and providers communicate lasted an average of 10.6 minutes and cost an average of $24.86 per encounter. Such costs should be weighed against the likely alternatives, such as the opportunity costs of having other hospital staff act as ad hoc interpreters; medical errors that could result from inadequate interpretation; and the fact that not providing such services may leave providers out of compliance with federal law. We also discuss ways in which providers could be compensated for providing interpreter services.

  9. Modular Laboratories—Cost-Effective and Sustainable Infrastructure for Resource-Limited Settings

    PubMed Central

    Bridges, Daniel J.; Colborn, James; Chan, Adeline S. T.; Winters, Anna M.; Dengala, Dereje; Fornadel, Christen M.; Kosloff, Barry

    2014-01-01

    High-quality laboratory space to support basic science, clinical research projects, or health services is often severely lacking in the developing world. Moreover, the construction of suitable facilities using traditional methods is time-consuming, expensive, and challenging to implement. Three real world examples showing how shipping containers can be converted into modern laboratories are highlighted. These include use as an insectary, a molecular laboratory, and a BSL-3 containment laboratory. These modular conversions have a number of advantages over brick and mortar construction and provide a cost-effective and timely solution to offer high-quality, user-friendly laboratory space applicable within the developing world. PMID:25223943

  10. Limiting the public cost of stationary battery deployment by combining applications

    NASA Astrophysics Data System (ADS)

    Stephan, A.; Battke, B.; Beuse, M. D.; Clausdeinken, J. H.; Schmidt, T. S.

    2016-07-01

    Batteries could be central to low-carbon energy systems with high shares of intermittent renewable energy sources. However, the investment attractiveness of batteries is still perceived as low, eliciting calls for policy to support deployment. Here we show how the cost of battery deployment can potentially be minimized by introducing an aspect that has been largely overlooked in policy debates and underlying analyses: the fact that a single battery can serve multiple applications. Batteries thereby can not only tap into different value streams, but also combine different risk exposures. To address this gap, we develop a techno-economic model and apply it to the case of lithium-ion batteries serving multiple stationary applications in Germany. Our results show that batteries could be attractive for investors even now if non-market barriers impeding the combination of applications were removed. The current policy debate should therefore be refocused so as to encompass the removal of such barriers.

  11. Effects of cryptic mortality and the hidden costs of using length limits in fishery management

    USGS Publications Warehouse

    Coggins, L.G.; Catalano, M.J.; Allen, M.S.; Pine, William E.; Walters, C.J.

    2007-01-01

    Fishery collapses cause substantial economic and ecological harm, but common management actions often fail to prevent overfishing. Minimum length limits are perhaps the most common fishing regulation used in both commercial and recreational fisheries, but their conservation benefits can be influenced by discard mortality of fish caught and released below the legal length. We constructed a computer model to evaluate how discard mortality could influence the conservation utility of minimum length regulations. We evaluated policy performance across two disparate fish life-history types: short-lived high-productivity (SLHP) and long-lived low-productivity (LLLP) species. For the life-history types, fishing mortality rates and minimum length limits that we examined, length limits alone generally failed to achieve sustainability when discard mortality rate exceeded about 0.2 for SLHP species and 0.05 for LLLP species. At these levels of discard mortality, reductions in overall fishing mortality (e.g. lower fishing effort) were required to prevent recruitment overfishing if fishing mortality was high. Similarly, relatively low discard mortality rates (>0.05) rendered maximum yield unobtainable and caused a substantial shift in the shape of the yield response surfaces. An analysis of fishery efficiency showed that length limits caused the simulated fisheries to be much less efficient, potentially exposing the target species and ecosystem to increased negative effects of the fishing process. Our findings suggest that for overexploited fisheries with moderate-to-high discard mortality rates, reductions in fishing mortality will be required to meet management goals. Resource managers should carefully consider impacts of cryptic mortality sources (e.g. discard mortality) on fishery sustainability, especially in recreational fisheries where release rates are high and effort is increasing in many areas of the world. ?? 2007 Blackwell Publishing Ltd.

  12. Analysis of EPA`s cost-effectiveness study for the coastal oil and gas effluent limitations guidelines

    SciTech Connect

    Veil, J.

    1995-05-01

    The US Environmental Protection Agency (EPA) conducted a cost-effectiveness (CE) analysis to estimate the incremental cost of complying with the proposed effluent limitation guidelines (ELGs) for the coastal oil and gas industry (EPA 1995a). EPA`s CE analysis calculates the pounds of each pollutant that would be removed if the chosen discharge option is selected. In 1993, EPA issued final ELGs for the offshore oil and gas industry and published an offshore CE analysis. The chemical characteristics of produced water from the offshore region are essentially the same as those of produced water from the coastal region. It was surprising, therefore, that EPA chose a much longer list of pollutants and generally stricter weighting factors for the coastal CE analysis. This report reviews the data, assumptions, and analyses used in EPA`s coastal CE analysis and identifies alternate data, assumptions, and analyses that could lead to significantly different cost-effectiveness conclusions. Two alternate lists of pollutants are proposed, along with recalculated weighting factors for several pollutants that contributed a large proportion of the total PEs removed--radium, benzo(a)pyrene, boron, and ammonia. By using different combinations of these variables, a range of revised estimates of CE is calculated.

  13. 29 CFR 1625.10 - Costs and benefits under employee benefit plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...—Individual benefit basis and “benefit package” basis. Cost comparisons and adjustments under section 4(f)(2...) “Benefit package” basis. As an alternative to the benefit-by-benefit basis, cost comparisons and..., subject to the limitations described below, cost comparisons and adjustments can be made with respect...

  14. 29 CFR 1625.10 - Costs and benefits under employee benefit plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...—Individual benefit basis and “benefit package” basis. Cost comparisons and adjustments under section 4(f)(2...) “Benefit package” basis. As an alternative to the benefit-by-benefit basis, cost comparisons and..., subject to the limitations described below, cost comparisons and adjustments can be made with respect...

  15. Cost tradeoffs in consequence management at nuclear power plants: A risk based approach to setting optimal long-term interdiction limits for regulatory analyses

    SciTech Connect

    Mubayi, V.

    1995-05-01

    The consequences of severe accidents at nuclear power plants can be limited by various protective actions, including emergency responses and long-term measures, to reduce exposures of affected populations. Each of these protective actions involve costs to society. The costs of the long-term protective actions depend on the criterion adopted for the allowable level of long-term exposure. This criterion, called the ``long term interdiction limit,`` is expressed in terms of the projected dose to an individual over a certain time period from the long-term exposure pathways. The two measures of offsite consequences, latent cancers and costs, are inversely related and the choice of an interdiction limit is, in effect, a trade-off between these two measures. By monetizing the health effects (through ascribing a monetary value to life lost), the costs of the two consequence measures vary with the interdiction limit, the health effect costs increasing as the limit is relaxed and the protective action costs decreasing. The minimum of the total cost curve can be used to calculate an optimal long term interdiction limit. The calculation of such an optimal limit is presented for each of five US nuclear power plants which were analyzed for severe accident risk in the NUREG-1150 program by the Nuclear Regulatory Commission.

  16. Factors limiting the sensitivity and dynamic range of a seismic system employing analog magnetic tape recording and a seismic amplifier with adjustable gain settings and several output levels

    USGS Publications Warehouse

    Eaton, Jerry P.; Van Schaack, John R.

    1977-01-01

    In the course of modernizing the low-speed-tape-recorder portable seismic systems and considering the possibilities for the design of a cassette-tape-recorder seismic refraction system, the factors that limit the sensitivity and dynamic range of such systems have been reviewed. These factors will first be stated briefly, and then their influence on systems such as the new 5-day-tape seismic system will be examined in more detail. To fix ideas, we shall assume that the system consists of the following elements: 1. A seismic sensor: usually a moving coil inertial seismometer with a period of about 1 second, a coil resistance of about 5000 ohms, and an effective motor constant of 1.0 V/cm/sec (across a 10K load terminating the seismometer sensitivity-and-damping-adjustment resistive network). 2. A seismic amplifier/voltage controlled oscillator unit made up of the following components: a) A fixed gain preamplifier with an input resistance of 10K and an internal noise level of 0.5 muVpp referred to the preamp input (0.1 Hz <= freq. <= 30 hz). b) An adjustable gain (0 to 42 db in 6 db steps) intermediate amplifier c) One or more fixed gain output amplifiers. d) Two sections of 6 db/octave bandpass filter serving to couple the 3 amplifier stages together. e) Voltage controlled oscillators for each output amplifier to produce modulated FM carriers for recording on separate tape tracks or modulated FM subcarriers for subsequent multiplexing and direct recording on tape in the California Network format. 3. An analog magnetic tape recorder: e.g. the PI 5100 (15/80 ips recording in the FM mode or in the direct mode with the 'broad-band' variant-of the Cal Net multiplex system, or 15/16 ips recording in the direct mode with the standard Cal Net multiplex system), or the Sony TC-126 cassette recorder operating in the direct record mode with the standard Cal Net multiplex system. 4. Appropriate magnetic tape playback equipment: e.g., the Bell and Howell 3700-B for the PI-5100 or

  17. Limitations of ozone data assimilation with adjustment of NOx emissions: mixed effects on NO2 forecasts over Beijing and surrounding areas

    NASA Astrophysics Data System (ADS)

    Tang, Xiao; Zhu, Jiang; Wang, ZiFa; Gbaguidi, Alex; Lin, CaiYan; Xin, JinYuan; Song, Tao; Hu, Bo

    2016-05-01

    This study investigates a cross-variable ozone data assimilation (DA) method based on an ensemble Kalman filter (EnKF) that has been used in the companion study to improve ozone forecasts over Beijing and surrounding areas. The main purpose is to delve into the impacts of the cross-variable adjustment of nitrogen oxide (NOx) emissions on the nitrogen dioxide (NO2) forecasts over this region during the 2008 Beijing Olympic Games. A mixed effect on the NO2 forecasts was observed through application of the cross-variable assimilation approach in the real-data assimilation (RDA) experiments. The method improved the NO2 forecasts over almost half of the urban sites with reductions of the root mean square errors (RMSEs) by 15-36 % in contrast to big increases of the RMSEs over other urban stations by 56-239 %. Over the urban stations with negative DA impacts, improvement of the NO2 forecasts (with 7 % reduction of the RMSEs) was noticed at night and in the morning versus significant deterioration during daytime (with 190 % increase of the RMSEs), suggesting that the negative data assimilation impacts mainly occurred during daytime. Ideal-data assimilation (IDA) experiments with a box model and the same cross-variable assimilation method confirmed the mixed effects found in the RDA experiments. In the same way, NOx emission estimation was improved at night and in the morning even under large biases in the prior emission, while it deteriorated during daytime (except for the case of minor errors in the prior emission). The mixed effects observed in the cross-variable data assimilation, i.e., positive data assimilation impacts on NO2 forecasts over some urban sites, negative data assimilation impacts over the other urban sites, and weak data assimilation impacts over suburban sites, highlighted the limitations of the EnKF under strong nonlinear relationships between chemical variables. Under strong nonlinearity between daytime ozone concentrations and NOx emissions

  18. Secondary Measures of Access to Abortion Services in the United States, 2011 and 2012: Gestational Age Limits, Cost, and Harassment

    PubMed Central

    Jerman, Jenna; Jones, Rachel K.

    2016-01-01

    Background Aspects of U.S. clinical abortion service provision such as gestational age limits, charges for abortion services, and anti-abortion harassment can impact the accessibility of abortion; this study documents changes in these measures between 2008 and 2012. Methods In 2012 and 2013, we surveyed all known abortion-providing facilities in the United States (n = 1,720). This study summarizes information obtained about gestational age limits, charges, and exposure to anti-abortion harassment among clinics; response rates for relevant items ranged from 54% (gestational limits) to 80% (exposure to harassment). Weights were constructed to compensate for nonresponding facilities. We also examine the distribution of abortions and abortion facilities by region. Findings Almost all abortion facilities (95%) offered abortions at 8 weeks’ gestation; 72% did so at 12 weeks, 34% at 20 weeks, and 16% at 24 weeks in 2012. In 2011 and 2012, the median charge for a surgical abortion at 10 weeks gestation was $495, and $500 for an early medication abortion, compared with $503 and $524 (adjusted for inflation) in 2009. In 2011, 84% of clinics experienced at least one form of harassment, only slightly higher than found in 2009. Hospitals and physicians’ offices accounted for a substantially smaller proportion of facilities in the Midwest and South. Clinics in the Midwest and South were exposed to more harassment than their counterparts in the Northeast and West. Conclusions Although there was a substantial decline in abortion incidence between 2008 and 2011, the secondary measures of abortion access examined in this study changed little during this time period. PMID:24981401

  19. Isoprene emissions from downy oak under water limitation during an entire growing season: what cost for growth?

    PubMed

    Genard-Zielinski, Anne-Cyrielle; Ormeño, Elena; Boissard, Christophe; Fernandez, Catherine

    2014-01-01

    Increases in the production of terpene- and phenolic-like compounds in plant species under abiotic stress conditions have been interpreted in physiological studies as a supplementary defense system due to their capacity to limit cell oxidation. From an ecological perspective however, these increases are only expected to confer competitive advantages if they do not imply a significant cost for the plant, that is, growth reduction. We investigated shifts of isoprene emissions, and to a lesser extent phenolic compound concentration, of Quercus pubescens Willd. from early leaf development to leaf senescence under optimal watering (control: C), mild and severe water stress (MS, SS). The impact of water stress was concomitantly assessed on plant physiological (chlorophyll fluorescence, stomatal conductance, net photosynthesis, water potential) functional (relative leaf water content, leaf mass per area ratio) and growth (aerial and root biomass) traits. Growth changes allowed to estimate the eventual costs related to the production of isoprene and phenolics. The total phenolic content was not modified under water stress whereas isoprene emissions were promoted under MS over the entire growing cycle despite the decline of Pn by 35%. Under SS, isoprene emissions remained similar to C all over the study despite the decline of Pn by 47% and were thereby clearly uncoupled to Pn leading to an overestimation of the isoprene emission factor by 44%. Under SS, maintenance of isoprene emissions and phenolic compound concentration resulted in very significant costs for the plants as growth rates were very significantly reduced. Under MS, increases of isoprene emission and maintenance of phenolic compound concentration resulted in moderate growth reduction. Hence, it is likely that investment in isoprene emissions confers Q. pubescens an important competitive advantage during moderate but not severe periods of water scarcity. Consequences of this response for air quality in North

  20. Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings

    PubMed Central

    Lam, Christopher T.; Krieger, Marlee S.; Gallagher, Jennifer E.; Asma, Betsy; Muasher, Lisa C.; Schmitt, John W.; Ramanujam, Nimmi

    2015-01-01

    Introduction Current guidelines by WHO for cervical cancer screening in low- and middle-income countries involves visual inspection with acetic acid (VIA) of the cervix, followed by treatment during the same visit or a subsequent visit with cryotherapy if a suspicious lesion is found. Implementation of these guidelines is hampered by a lack of: trained health workers, reliable technology, and access to screening facilities. A low cost ultra-portable Point of Care Tampon based digital colposcope (POCkeT Colposcope) for use at the community level setting, which has the unique form factor of a tampon, can be inserted into the vagina to capture images of the cervix, which are on par with that of a state of the art colposcope, at a fraction of the cost. A repository of images to be compiled that can be used to empower front line workers to become more effective through virtual dynamic training. By task shifting to the community setting, this technology could potentially provide significantly greater cervical screening access to where the most vulnerable women live. The POCkeT Colposcope’s concentric LED ring provides comparable white and green field illumination at a fraction of the electrical power required in commercial colposcopes. Evaluation with standard optical imaging targets to assess the POCkeT Colposcope against the state of the art digital colposcope and other VIAM technologies. Results Our POCkeT Colposcope has comparable resolving power, color reproduction accuracy, minimal lens distortion, and illumination when compared to commercially available colposcopes. In vitro and pilot in vivo imaging results are promising with our POCkeT Colposcope capturing comparable quality images to commercial systems. Conclusion The POCkeT Colposcope is capable of capturing images suitable for cervical lesion analysis. Our portable low cost system could potentially increase access to cervical cancer screening in limited resource settings through task shifting to community

  1. Regulatory and cost barriers are likely to limit biosimilar development and expected savings in the near future.

    PubMed

    Grabowski, Henry G; Guha, Rahul; Salgado, Maria

    2014-06-01

    In March 2010 Congress established an abbreviated Food and Drug Administration approval pathway for biosimilars-drugs that are very similar but not identical to a reference biological product and cost less. Because bringing biosimilars to the market currently requires large investments of money, fewer biosimilars are expected to enter the biologics market than has been the case with generic drugs entering the small-molecule drug market. Additionally, given the high regulatory hurdles to obtaining interchangeability-which would allow pharmacists to substitute a biosimilar for its reference product, subject to evolving state substitution laws-most biosimilars will likely compete as therapeutic alternatives instead of as therapeutic equivalents. In other words, biosimilars will need to compete with their reference product on the basis of quality; price; and manufacturer's reputation with physicians, insurers, and patient groups. Biosimilars also will face dynamic competition from new biologics in the same therapeutic class-including "biobetters," which offer incremental improvements on reference products, such as extended duration of action. The prospects for significant cost savings from the use of biosimilars appear to be limited for the next several years, but their use should increase over time because of both demand- and supply-side factors.

  2. Overcoming the production limitations of Photorhabdus temperata ssp. temperata strain K122 bioinsecticides in low-cost medium.

    PubMed

    Jallouli, Wafa; Jaoua, Samir; Zouari, Nabil

    2011-10-01

    For low-cost production of Photorhabdus temperata ssp. temperata strain K122 bioinsecticide, a cheap complex medium was optimized. Diluted seawater was used as the source of micronutrients, especially sodium chloride, involved in the improvement of cell density, culturability and oral toxicity of the bacterium P. temperata against Ephestia kuehniella larvae. Thus, the new formulated medium was composed only of 10 g/l of soya bean meal, used as the carbon and nitrogen main source, mixed in sevenfold diluted seawater. At such conditions, several limitations of P. temperata bioinsecticide productions were shown to be overcome. The appearance of variants small colony polymorphism was completely avoided. Thus, the strain K122 was maintained at the primary form even after prolonged incubation. Moreover, the viable but nonculturable state was partially overcome, since the ability of P. temperata cells to form colonies on the solid medium was prolonged until 78 h of incubation. In addition, when cultured in the complex medium, P. temperata cells were produced at high cell density of 12 × 10(8) cells/ml and exhibited 81.48% improvement of oral toxicity compared to those produced in the optimized medium. With such medium, the large-scale bioinsecticides production into 3-l fully controlled fermenter improved the total cell counts, CFU counts and oral toxicity by 20, 5.81 and 16.73%, respectively. This should contribute to a significant reduction of production cost of highly potent P. temperata strain K122 cells, useful as a bioinsecticide.

  3. Medicare program; schedules of limits and prospectively determined payment rates for skilled nursing facility inpatient routine service costs--HCFA. Final notice with comment period.

    PubMed

    1997-10-01

    This final notice with comment period sets forth an updated schedule of limits on skilled nursing facility (SNF) routine service costs for which payment may be made under the Medicare program and sets forth an updated schedule of payment rates for low Medicare volume SNFs that elect to receive prospectively determined payment rates for routine service costs. Section 1888(a) of the Social Security Act (the Act) requires that the Secretary update the per diem cost limits for SNF routine service costs for cost reporting periods beginning on or after October 1, 1995, and every 2 years thereafter. In addition, section 1888(d)(4) of the Act requires the Secretary to establish and publish prospectively determined payment rates at least 90 days prior to the beginning of the Federal fiscal year (FY) to which such rates are to be applied.

  4. 38 CFR 17.121 - Limitations on payment or reimbursement of the costs of emergency hospital care and medical...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reimbursement of the costs of emergency hospital care and medical services not previously authorized. 17.121... reimbursement of the costs of emergency hospital care and medical services not previously authorized. Claims for payment or reimbursement of the costs of emergency hospital care or medical services not...

  5. 38 CFR 17.121 - Limitations on payment or reimbursement of the costs of emergency hospital care and medical...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... reimbursement of the costs of emergency hospital care and medical services not previously authorized. 17.121... reimbursement of the costs of emergency hospital care and medical services not previously authorized. Claims for payment or reimbursement of the costs of emergency hospital care or medical services not...

  6. When it is costly to have a caring mother: food limitation erases the benefits of parental care in earwigs.

    PubMed

    Meunier, Joël; Kölliker, Mathias

    2012-08-23

    The aggregation of parents with offspring is generally associated with different forms of care that improve offspring survival at potential costs to parents. Under poor environments, the limited amount of resources available can increase the level of competition among family members and consequently lead to adaptive changes in parental investment. However, it remains unclear as to what extent such changes modify offspring fitness, particularly when offspring can survive without parents such as in the European earwig, Forficula auricularia. Here, we show that under food restriction, earwig maternal presence decreased offspring survival until adulthood by 43 per cent. This effect was independent of sibling competition and was expressed after separation from the female, indicating lasting detrimental effects. The reduced benefits of maternal presence on offspring survival were not associated with higher investment in future reproduction, suggesting a condition-dependent effect of food restriction on mothers and local mother-offspring competition for food. Overall, these findings demonstrate for the first time a long-term negative effect of maternal presence on offspring survival in a species with maternal care, and highlight the importance of food availability in the early evolution of family life.

  7. Medicare program; reissuance of the wage index in the 1981 schedule of limits on hospital per diem inpatient general routine operating costs--HCFA. Proposed notice.

    PubMed

    1984-02-17

    We are reissuing for public comment the change in the types of data that were used to calculate the wage index that was contained in the schedules of limits on hospital per diem inpatient general routine operating costs reimbursable under Medicare that were applicable to cost reporting periods beginning on or after July 1, 1981 and for cost reporting periods ending after September 30, 1981. The cost limits for cost reporting periods beginning on or after October 1, 1982 are governed by the notice published in the Federal Register on September 30, 1982 (47 FR 43296) and August 30, 1983 (48 FR 39426) and are not affected by this reissuance. The wage index was originally issued as part of the schedule of limits published on June 30, 1981 (46 FR 33637) and September 30, 1981 (46 FR 48010) and is being reissued as the result of the April 29, 1983 decision of the United States District Court for the District of Columbia in the case of District of Columbia Hospital Association, et al. v Heckler, et al. (No. 82-2520 DDC). The District Court held that the 1981 schedule of hospital cost limits was invalid for failure to comply with the Administrative Procedure Act insofar as the schedule incorporated or was formulated by using a wage index that was calculated by excluding Federal government hospital wage data.

  8. Chiropractic Adjustment

    MedlinePlus

    ... structural alignment and improve your body's physical function. Low back pain, neck pain and headache are the most common ... treated. Chiropractic adjustment can be effective in treating low back pain, although much of the research done shows only ...

  9. Adjustment disorder

    MedlinePlus

    ... from other people Skipped heartbeats and other physical complaints Trembling or twitching To have adjustment disorder, you ... ADAM Health Solutions. About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe to RSS Follow ...

  10. Capping risk adjustment?

    PubMed

    Eugster, Patrick; Sennhauser, Michèle; Zweifel, Peter

    2010-07-01

    When premiums are community-rated, risk adjustment (RA) serves to mitigate competitive insurers' incentive to select favorable risks. However, unless fully prospective, it also undermines their incentives for efficiency. By capping its volume, one may try to counteract this tendency, exposing insurers to some financial risk. This in term runs counter the quest to refine the RA formula, which would increase RA volume. Specifically, the adjuster, "Hospitalization or living in a nursing home during the previous year" will be added in Switzerland starting 2012. This paper investigates how to minimize the opportunity cost of capping RA in terms of increased incentives for risk selection.

  11. Detection limits and cost comparisons of human- and gull-associated conventional and quantitative PCR assays in artificial and environmental waters

    USGS Publications Warehouse

    Riedel, Timothy E.; Zimmer-Faust, Amity G.; Thulsiraj, Vanessa; Madi, Tania; Hanley, Kaitlyn T.; Ebentier, Darcy L.; Byappanahalli, Muruleedhara N.; Layton, Blythe; Raith, Meredith; Boehm, Alexandria B.; Griffith, John F.; Holden, Patricia A.; Shanks, Orin C.; Weisberg, Stephen B.; Jay, Jennifer A.

    2014-01-01

    Some molecular methods for tracking fecal pollution in environmental waters have both PCR and quantitative PCR (qPCR) assays available for use. To assist managers in deciding whether to implement newer qPCR techniques in routine monitoring programs, we compared detection limits (LODs) and costs of PCR and qPCR assays with identical targets that are relevant to beach water quality assessment. For human-associated assays targeting Bacteroidales HF183 genetic marker, qPCR LODs were 70 times lower and there was no effect of target matrix (artificial freshwater, environmental creek water, and environmental marine water) on PCR or qPCR LODs. The PCR startup and annual costs were the lowest, while the per reaction cost was 62% lower than the Taqman based qPCR and 180% higher than the SYBR based qPCR. For gull-associated assays, there was no significant difference between PCR and qPCR LODs, target matrix did not effect PCR or qPCR LODs, and PCR startup, annual, and per reaction costs were lower. Upgrading to qPCR involves greater startup and annual costs, but this increase may be justified in the case of the human-associated assays with lower detection limits and reduced cost per sample.

  12. Detection limits and cost comparisons of human- and gull-associated conventional and quantitative PCR assays in artificial and environmental waters.

    PubMed

    Riedel, Timothy E; Zimmer-Faust, Amity G; Thulsiraj, Vanessa; Madi, Tania; Hanley, Kaitlyn T; Ebentier, Darcy L; Byappanahalli, Muruleedhara; Layton, Blythe; Raith, Meredith; Boehm, Alexandria B; Griffith, John F; Holden, Patricia A; Shanks, Orin C; Weisberg, Stephen B; Jay, Jennifer A

    2014-04-01

    Some molecular methods for tracking fecal pollution in environmental waters have both PCR and quantitative PCR (qPCR) assays available for use. To assist managers in deciding whether to implement newer qPCR techniques in routine monitoring programs, we compared detection limits (LODs) and costs of PCR and qPCR assays with identical targets that are relevant to beach water quality assessment. For human-associated assays targeting Bacteroidales HF183 genetic marker, qPCR LODs were 70 times lower and there was no effect of target matrix (artificial freshwater, environmental creek water, and environmental marine water) on PCR or qPCR LODs. The PCR startup and annual costs were the lowest, while the per reaction cost was 62% lower than the Taqman based qPCR and 180% higher than the SYBR based qPCR. For gull-associated assays, there was no significant difference between PCR and qPCR LODs, target matrix did not effect PCR or qPCR LODs, and PCR startup, annual, and per reaction costs were lower. Upgrading to qPCR involves greater startup and annual costs, but this increase may be justified in the case of the human-associated assays with lower detection limits and reduced cost per sample.

  13. 20 CFR 667.210 - What administrative cost limits apply to Workforce Investment Act title I grants?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... reserve for Statewide activities, the State may spend up to five percent (5%) of the amount allotted under... reserved for local administrative costs needs to be allocated back to the individual funding streams....

  14. Clinical consequences and cost of limiting use of vancomycin for perioperative prophylaxis: example of coronary artery bypass surgery.

    PubMed Central

    Zanetti, G.; Goldie, S. J.; Platt, R.

    2001-01-01

    Routine us of vancomycin for perioperative prophylaxis is discouraged, principally to minimize microbial resistance to it. However, outcomes and costs of this recommendation have not been assessed. We used decision-analytic models to compare clinical results and cost-effectiveness of no prophylaxis, cefazolin, and vancomycin, in coronary artery bypass graft surgery. In the base case, vancomycin resulted in 7% fewer surgical site infections and 1% lower all-cause mortality and saved $117 per procedure, compared with cefazolin. Cefazolin, in turn, resulted in substantially fewer infections and deaths and lower costs than no prophylaxis. We conclude that perioperative antibiotic prophylaxis with vancomycin is usually more effective and less expensive than cefazolin. Data on vancomycin's impact on resistance are needed to quantify the trade-off between individual patients' improved clinical outcomes and lower costs and the future long-term consequences to society. PMID:11747694

  15. Medicare program; reissuance of the wage index in the 1981 schedule of limits on hospital per diem inpatient general routine operating costs--HCFA. Final notice.

    PubMed

    1984-11-26

    This notice affirms the use of the wage index that was used to calculate the 1981 schedule of limits on hospital per diem inpatient general routine operating costs, which was issued on June 30, 1981 [46 FR 33637], and September 30, 1981 [46 FR 48010]. The 1981 wage index was reissued for public comment on February 17, 1984 [49 FR 6175].

  16. 45 CFR 263.13 - Is there a limit on the amount of Federal TANF funds that a State may spend on administrative costs?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Is there a limit on the amount of Federal TANF funds that a State may spend on administrative costs? 263.13 Section 263.13 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND...

  17. 20 CFR 668.825 - Does the WIA administrative cost limit for States and local areas apply to section 166 grants?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Does the WIA administrative cost limit for States and local areas apply to section 166 grants? 668.825 Section 668.825 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) INDIAN AND NATIVE AMERICAN...

  18. 20 CFR 668.825 - Does the WIA administrative cost limit for States and local areas apply to section 166 grants?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Does the WIA administrative cost limit for States and local areas apply to section 166 grants? 668.825 Section 668.825 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) INDIAN AND NATIVE AMERICAN...

  19. 20 CFR 668.825 - Does the WIA administrative cost limit for States and local areas apply to section 166 grants?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Does the WIA administrative cost limit for States and local areas apply to section 166 grants? 668.825 Section 668.825 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) INDIAN AND NATIVE AMERICAN...

  20. Investigation of truck size and weight limits: technical supplement volume 7. carrier, market and regional cost and energy tradeoffs, part i. Final report oct 78-oct 81

    SciTech Connect

    Maio, D.J.

    1982-10-01

    This volume expands upon the summary results in the Secretary's Report to Congress and provides a more comprehensive treatment of the productivity and fuel tradeoffs among the categories of truck size, weight and configuration limits. Disaggregations of impacts among freight service user groups are reported to provide information to the interest groups most affected by alternative limit changes. It also presents an analysis of the sensitivity of the reported transport cost and fuel impacts of alternative limits to the possible inaccuracies in the analytical methods and data available to the study.

  1. Shaft adjuster

    DOEpatents

    Harry, H.H.

    1988-03-11

    Abstract and method for the adjustment and alignment of shafts in high power devices. A plurality of adjacent rotatable angled cylinders are positioned between a base and the shaft to be aligned which when rotated introduce an axial offset. The apparatus is electrically conductive and constructed of a structurally rigid material. The angled cylinders allow the shaft such as the center conductor in a pulse line machine to be offset in any desired alignment position within the range of the apparatus. 3 figs.

  2. Shaft adjuster

    DOEpatents

    Harry, Herbert H.

    1989-01-01

    Apparatus and method for the adjustment and alignment of shafts in high power devices. A plurality of adjacent rotatable angled cylinders are positioned between a base and the shaft to be aligned which when rotated introduce an axial offset. The apparatus is electrically conductive and constructed of a structurally rigid material. The angled cylinders allow the shaft such as the center conductor in a pulse line machine to be offset in any desired alignment position within the range of the apparatus.

  3. 38 CFR 17.121 - Limitations on payment or reimbursement of the costs of emergency treatment not previously...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... VA has an agreement with to furnish health care services for veterans), which means the non-VA... emergency treatment: (1) Could have been transferred from the non-VA facility to a VA medical center (or...) Continued non-emergency treatment. Claims for payment or reimbursement of the costs of emergency...

  4. 38 CFR 17.121 - Limitations on payment or reimbursement of the costs of emergency treatment not previously...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... VA has an agreement with to furnish health care services for veterans), which means the non-VA... emergency treatment: (1) Could have been transferred from the non-VA facility to a VA medical center (or...) Continued non-emergency treatment. Claims for payment or reimbursement of the costs of emergency...

  5. Accuracy of a Low-Cost Novel Computer-Vision Dynamic Movement Assessment: Potential Limitations and Future Directions

    NASA Astrophysics Data System (ADS)

    McGroarty, M.; Giblin, S.; Meldrum, D.; Wetterling, F.

    2016-04-01

    The aim of the study was to perform a preliminary validation of a low cost markerless motion capture system (CAPTURE) against an industry gold standard (Vicon). Measurements of knee valgus and flexion during the performance of a countermovement jump (CMJ) between CAPTURE and Vicon were compared. After correction algorithms were applied to the raw CAPTURE data acceptable levels of accuracy and precision were achieved. The knee flexion angle measured for three trials using Capture deviated by -3.8° ± 3° (left) and 1.7° ± 2.8° (right) compared to Vicon. The findings suggest that low-cost markerless motion capture has potential to provide an objective method for assessing lower limb jump and landing mechanics in an applied sports setting. Furthermore, the outcome of the study warrants the need for future research to examine more fully the potential implications of the use of low-cost markerless motion capture in the evaluation of dynamic movement for injury prevention.

  6. A simplified, cost- and time-effective procedure for genotyping pearl millet in resource-limited laboratories

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Procedures for DNA extraction and genotyping of large plant populations are cumbersome and expensive for resource-limited laboratories. Through eliminating or changing several steps used in DNA extraction, PCR amplification and PAGE electrophoresis in pearl millet [Pennisetum glaucum (L.) R. Br.], w...

  7. National Democratic Institute Grant’s Security Costs and Impact Generally Supported, but Department of State Oversight Limited

    DTIC Science & Technology

    2010-10-13

    impact of all of its work in meeting grant goals and objectives. DRL noted that it continues to take steps to improve monitoring and evaluation we...and objectives. DRL noted that it continues to take steps to improve monitoring and evaluation . For example, it is requiring more comprehensive...among other things, demonstrated contributions from these meetings. Limited Monitoring and Evaluation Plan Contributed to Problems in Assessing

  8. Adjustment of inpatient care reimbursement for nursing intensity.

    PubMed

    Welton, John M; Zone-Smith, Laurie; Fischer, Mary H

    2006-11-01

    The Centers for Medicare and Medicaid Services has begun an ambitious recalibration of the inpatient prospective payment system, the first since its introduction in 1983. Unfortunately, inpatient nursing care has been overlooked in the new payment system and continues to be treated as a fixed cost and billed at a set per-diem "room and board" fee despite the known variability of nursing intensity across different care settings and diagnoses. This article outlines the historical influences regarding costing, billing, and reimbursement of inpatient nursing care and provides contemporary evidence about the variability of nursing intensity and costs at acute care hospitals in the United States. A remedy is proposed to overcome the existing limitations of the Inpatient Prospective Payment System by creating a new nursing cost center and nursing intensity adjustment by DRG for each routine-and intensive-care day of stay to allow independent costing, billing, and reimbursement of inpatient nursing care.

  9. Transmission line capital costs

    SciTech Connect

    Hughes, K.R.; Brown, D.R.

    1995-05-01

    The displacement or deferral of conventional AC transmission line installation is a key benefit associated with several technologies being developed with the support of the U.S. Department of Energy`s Office of Energy Management (OEM). Previous benefits assessments conducted within OEM have been based on significantly different assumptions for the average cost per mile of AC transmission line. In response to this uncertainty, an investigation of transmission line capital cost data was initiated. The objective of this study was to develop a database for preparing preliminary estimates of transmission line costs. An extensive search of potential data sources identified databases maintained by the Bonneville Power Administration (BPA) and the Western Area Power Administration (WAPA) as superior sources of transmission line cost data. The BPA and WAPA data were adjusted to a common basis and combined together. The composite database covers voltage levels from 13.8 to 765 W, with cost estimates for a given voltage level varying depending on conductor size, tower material type, tower frame type, and number of circuits. Reported transmission line costs vary significantly, even for a given voltage level. This can usually be explained by variation in the design factors noted above and variation in environmental and land (right-of-way) costs, which are extremely site-specific. Cost estimates prepared from the composite database were compared to cost data collected by the Federal Energy Regulatory Commission (FERC) for investor-owned utilities from across the United States. The comparison was hampered because the only design specifications included with the FERC data were voltage level and line length. Working within this limitation, the FERC data were not found to differ significantly from the composite database. Therefore, the composite database was judged to be a reasonable proxy for estimating national average costs.

  10. Genotype assays and third-line ART in resource-limited settings: A simulation and cost-effectiveness analysis of a planned clinical trial

    PubMed Central

    Lorenzana, Sarah B.; Hughes, Michael D.; Grinsztejn, Beatriz; Collier, Ann C.; Luz, Paula Mendes; Freedberg, Kenneth A.; Wood, Robin; Levison, Julie H.; Mugyenyi, Peter N.; Salata, Robert; Wallis, Carole L.; Weinstein, Milton C.; Schooley, Robert T.; Walensky, Rochelle P.

    2012-01-01

    Objectives To project the clinical and economic outcomes of a genotype assay for selection of third-line antiretroviral therapy (ART) in resource-limited settings, as per the planned international A5288 trial (MULTI-OCTAVE). Methods We used the Cost-effectiveness of Preventing AIDS Complications (CEPAC)-International Model to compare three strategies for subjects who have failed second-line ART in South Africa: (1) Sustained second-line: no genotype assay, all subjects remain on second-line ART; (2) A5288: genotype to determine the resistance profile and assign an appropriate regimen; or (3) Population-based third-line: no genotype, all subjects switch to a potent third-line regimen. Model inputs are from published data in South Africa. Resistance profiles, ART regimens, and efficacy data were those used for trial planning. Results Projected life expectancy for sustained second-line, A5288, and population-based third-line are 61.1, 103.8, and 104.2 months. Compared to sustained second-line ($12,460), per person lifetime costs increase for the A5288 ($39,250) and population-based ($44,120) strategies. The incremental cost-effectiveness ratio of A5288, compared to sustained second-line, is $7,500/year of life saved (YLS), and for population-based third-line, compared to A5288, is $154,500/YLS. In the A5288 strategy, very late presentation to care, coupled with lengthy delays to obtain the genotype, dramatically reduces 5-yr survival, making the population-based third-line strategy more attractive. Conclusions We project that, while the public health approach to third-line therapy is unaffordable, genotype assays and third-line ART in resource-limited settings will increase survival and be cost-effective compared to the population-based approach, supporting the value of an efficacy study. PMID:22343964

  11. Using cost-benefit analysis and social return on investment to evaluate the impact of social enterprise: Promises, implementation, and limitations.

    PubMed

    Cordes, Joseph J

    2016-11-21

    Since the early 2000's there has been growing interest in using the Social Return on Investment (SROI) as a measure for assessing the performance of social enterprises. By analogy with its business counterpart, the Return on Investment (ROI), the SROI is a metric that compares the monetized social costs of a program with the monetized social benefits of achieving an outcome (or set of outcomes). For example, calculating the SROI of a nonprofit half-way house for drug addicts might involve estimating the reduced social costs attributable to successful rehabilitation of addicts, and comparing this to the social costs of operating the half-way house. Alternatively, the total return of a for-profit social enterprise providing affordable housing might consist both of the traditional private return on investment along with the economic value of meeting the housing needs of lower income households. Early descriptions of the methodology for calculating the SROI suggest that the approach initially evolved from standard methodologies found in the business finance literature for evaluating investments, with the important twist that nonprofit sector returns/payoffs are defined in broader social terms (Thornley, Anderson, & Dixon, 2016). Yet, someone who is familiar with the economic literature on cost benefit analysis (CBA) as it is applied to the evaluation of public programs cannot help but be struck by the similarity between the outcomes that CBA is intended to measure, and those that are the object of efforts to calculate the SROI. One implication is that the literature on the theory and practice of cost benefit analysis offers useful lessons about how to measure the social return on investment, as well as about potential caveats and limitations that need to be confronted when attempting to undertake an analysis of the SROI. The paper discusses the potential uses and limitations of CBA and SROI as tools that governments, private donor/investors, and foundations can use to

  12. Medicare program; invalidation of the wage index in the schedule of limits on Hospital per diem inpatient general routine operating costs for cost reporting periods beginning on or after July 1, 1981 and ending with cost reporting periods beginning on or before September 30, 1982--HCFA. Notice.

    PubMed

    1983-09-02

    This notice announces the April 29, 1983 decision of the United States District Court for the District of Columbia in the case of District of Columbia Hospital Association, et al. v. Heckler, et al. (No. 82-2520 D.D.C.). In its decision, the court ordered us to publish a notice in the Federal Register stating that the 1981 schedule of limits on hospital per diem inpatient general routine operating costs has been declared invalid with regard to the wage index for cost reporting periods beginning on or before July 1, 1981 and ending with cost reporting periods beginning on or before September 30, 1982. The District Court held that the decision to exclude Federal government hospital wage data from the computation of the wage index used in the 1981 Medicare hospital cost limits, without providing prior notice and an opportunity for comment, was in violation of the rulemaking requirements of the Administrative Procedure Act. The decision of the District Court does not apply to cost reporting periods beginning on or after October 1, 1982. The cost limits for periods beginning on or after October 1, 1982 are contained in the interim final notice with comment period published in the Federal Register on September 30, 1982 (47 FR 43296).

  13. 42 CFR 412.316 - Geographic adjustment factors.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Inpatient Hospital Capital Costs Basic Methodology for Determining the Federal Rate for Capital-Related Costs § 412.316 Geographic adjustment factors. (a) Local cost variation. CMS adjusts for local cost variation based on the hospital wage index value that is applicable to the hospital under subpart D of...

  14. Disability-adjusted life years and economic cost assessment of the health effects related to PM2.5 and PM10 pollution in Mumbai and Delhi, in India from 1991 to 2015.

    PubMed

    Maji, Kamal Jyoti; Dikshit, Anil Kumar; Deshpande, Ashok

    2016-12-15

    Particulate air pollution is becoming a serious public health concern in urban cities in India due to air pollution-related health effects associated with disability-adjusted life years (DALYs) and economic loss. To obtain the quantitative result of health impact of particulate matter (PM) in most populated Mumbai City and most polluted Delhi City in India, an epidemiology-based exposure-response function has been used to calculate the attributable number of mortality and morbidity cases from 1991 to 2015 in a 5-year interval and the subsequent DALYs, and economic cost is estimated of the health damage based on unit values of the health outcomes. Here, we report the attributable number of mortality due to PM10 in Mumbai and Delhi increased to 32,014 and 48,651 in 2015 compared with 19,291 and 19,716 in year 1995. And annual average mortality due to PM2.5 in Mumbai and Delhi was 10,880 and 10,900. Premature cerebrovascular disease (CEV), ischemic heart disease (IHD), and chronic obstructive pulmonary disease (COPD) causes are about 35.3, 33.3, and 22.9% of PM2.5-attributable mortalities. Total DALYs due to PM10 increased from 0.34 million to 0.51 million in Mumbai and 0.34 million to 0.75 million in Delhi from average year 1995 to 2015. Among all health outcomes, mortality and chronic bronchitis shared about 95% of the total DALYs. Due to PM10, the estimated total economic cost at constant price year 2005 US$ increased from 2680.87 million to 4269.60 million for Mumbai City and 2714.10 million to 6394.74 million for Delhi City, from 1995 to 2015, and the total amount accounting about 1.01% of India's gross domestic product (GDP). A crucial presumption is that in 2030, PM10 levels would have to decline by 44% (Mumbai) and 67% (Delhi) absolutely to maintain the same health outcomes in year 2015 levels. The results will help policy makers from pollution control board for further cost-benefit analyses of air pollution management programs in Mumbai and Delhi.

  15. Nonlinear relative-proportion-based route adjustment process for day-to-day traffic dynamics: modeling, equilibrium and stability analysis

    NASA Astrophysics Data System (ADS)

    Zhu, Wenlong; Ma, Shoufeng; Tian, Junfang; Li, Geng

    2016-11-01

    Travelers' route adjustment behaviors in a congested road traffic network are acknowledged as a dynamic game process between them. Existing Proportional-Switch Adjustment Process (PSAP) models have been extensively investigated to characterize travelers' route choice behaviors; PSAP has concise structure and intuitive behavior rule. Unfortunately most of which have some limitations, i.e., the flow over adjustment problem for the discrete PSAP model, the absolute cost differences route adjustment problem, etc. This paper proposes a relative-Proportion-based Route Adjustment Process (rePRAP) maintains the advantages of PSAP and overcomes these limitations. The rePRAP describes the situation that travelers on higher cost route switch to those with lower cost at the rate that is unilaterally depended on the relative cost differences between higher cost route and its alternatives. It is verified to be consistent with the principle of the rational behavior adjustment process. The equivalence among user equilibrium, stationary path flow pattern and stationary link flow pattern is established, which can be applied to judge whether a given network traffic flow has reached UE or not by detecting the stationary or non-stationary state of link flow pattern. The stability theorem is proved by the Lyapunov function approach. A simple example is tested to demonstrate the effectiveness of the rePRAP model.

  16. Melt-and-mold fabrication (MnM-Fab) of reconfigurable low-cost devices for use in resource-limited settings.

    PubMed

    Li, Zhi; Tevis, Ian D; Oyola-Reynoso, Stephanie; Newcomb, Lucas B; Halbertsma-Black, Julian; Bloch, Jean-Francis; Thuo, Martin

    2015-12-01

    Interest in low-cost analytical devices (especially for diagnostics) has recently increased; however, concomitant translation to the field has been slow, in part due to personnel and supply-chain challenges in resource-limited settings. Overcoming some of these challenges require the development of a method that takes advantage of locally available resources and/or skills. We report a Melt-and-mold fabrication (MnM Fab) approach to low-cost and simple devices that has the potential to be adapted locally since it requires a single material that is recyclable and simple skills to access multiple devices. We demonstrated this potential by fabricating entry level bio-analytical devices using an affordable low-melting metal alloy, Field's metal, with molds produced from known materials such as plastic (acrylonitrile-butadiene-styrene (ABS)), glass, and paper. We fabricated optical gratings then 4×4 well plates using the same recycled piece of metal. We then reconfigured the well plates into rapid prototype microfluidic devices with which we demonstrated laminar flow, droplet generation, and bubble formation from T-shaped channels. We conclude that this MnM-Fab method is capable of addressing some challenges typically encountered with device translation, such as technical know-how or material supply, and that it can be applied to other devices, as needed in the field, using a single moldable material.

  17. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  18. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  19. Comparable-Worth Adjustments: Yes--Comparable-Worth Adjustments: No.

    ERIC Educational Resources Information Center

    Galloway, Sue; O'Neill, June

    1985-01-01

    Two essays address the issue of pay equity and present opinions favoring and opposing comparable-worth adjustments. Movement of women out of traditionally female jobs, the limits of "equal pay," fairness of comparable worth and market-based wages, implementation and efficiency of comparable worth system, and alternatives to comparable…

  20. Short Communication: A Low-Cost Method for Analyzing Nevirapine Levels in Hair as a Marker of Adherence in Resource-Limited Settings

    PubMed Central

    Yang, Qiyun; Bacchetti, Peter; Huang, Yong

    2014-01-01

    Abstract The measurement of antiretroviral concentrations in hair is emerging as an important technology to objectively quantify adherence to combination antiretroviral therapy. Hair levels of antiretrovirals are the strongest independent predictor of virologic success in large prospective cohorts of HIV-infected patients and surpass self-report in predicting outcomes. Hair is easy to collect and store, but validated methods to analyze antiretroviral levels in hair using liquid chromatography tandem mass spectrometry (LC-MS/MS) are expensive. We report here on the development of a thin-layer chromatography (TLC) assay for the semiquantitative analysis of nevirapine in hair. TLC assay results from 11 samples were consistent with results using LC-MS/MS [Spearman correlation coefficient 0.99 (95% CI 0.95–0.996)]. This simple, low-cost method of analyzing nevirapine concentrations in hair may provide a novel monitoring tool for antiretroviral adherence in resource-limited settings and merits further study in clinical settings. PMID:24164410

  1. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Although administrative in nature, costs of information technology—computer hardware and software—needed... activities or the overall management of the WtW system; and (5) Costs of information systems related to... WtW including: (i) Accounting, budgeting, financial and cash management functions; (ii)...

  2. Report: No Intent to Underestimate Costs Was Found, but Supporting Documentation for EPA’s Final Rule Limiting Sulfur in Gasoline Was Incomplete or Inaccurate in Several Instances

    EPA Pesticide Factsheets

    Report #16-P-0122, March 29, 2016. Inaccurate or incomplete documentation of the EPA's cost modeling could prevent a third party from obtaining a full and accurate understanding of how the EPA arrived at its cost estimate for the Tier 3 rule.

  3. 78 FR 63465 - Adjusting Civil Money Penalties for Inflation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... CORPORATION Adjusting Civil Money Penalties for Inflation AGENCY: Farm Credit System Insurance Corporation. ACTION: Notice. SUMMARY: This notice assesses the need for cost-of-living adjustments to the civil money.... Statutes Concerning Inflation Adjustment of Civil Money Penalties The Federal Civil Penalties...

  4. Risk-Adjustment Simulation: Plans May Have Incentives To Distort Mental Health And Substance Use Coverage

    PubMed Central

    Montz, Ellen; Layton, Tim; Busch, Alisa B.; Ellis, Randall P.; Rose, Sherri; McGuire, Thomas G.

    2016-01-01

    Under the Affordable Care Act, the risk-adjustment program is designed to compensate health plans for enrolling people with poorer health status so that plans compete on cost and quality rather than the avoidance of high-cost individuals. This study examined health plan incentives to limit covered services for mental health and substance use disorders under the risk-adjustment system used in the health insurance Marketplaces. Through a simulation of the program on a population constructed to reflect Marketplace enrollees, we analyzed the cost consequences for plans enrolling people with mental health and substance use disorders. Our assessment points to systematic underpayment to plans for people with these diagnoses. We document how Marketplace risk adjustment does not remove incentives for plans to limit coverage for services associated with mental health and substance use disorders. Adding mental health and substance use diagnoses used in Medicare Part D risk adjustment is one potential policy step toward addressing this problem in the Marketplaces. PMID:27269018

  5. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... points. In either case, round the sum down to the nearest eighth of one percent. (3) If the result is... cash flows back to the first disbursement date using the Cost of Money ceiling from paragraph (d)...

  6. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... points. In either case, round the sum down to the nearest eighth of one percent. (3) If the result is... cash flows back to the first disbursement date using the Cost of Money ceiling from paragraph (d)...

  7. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... points. In either case, round the sum down to the nearest eighth of one percent. (3) If the result is... cash flows back to the first disbursement date using the Cost of Money ceiling from paragraph (d)...

  8. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Although administrative in nature, costs of information technology—computer hardware and software—needed... information, including job listing information, job skills information, and demand occupation information; and...) Developing systems and procedures, including information systems, required for these administrative......

  9. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Although administrative in nature, costs of information technology—computer hardware and software—needed... information, including job listing information, job skills information, and demand occupation information; and...) Developing systems and procedures, including information systems, required for these administrative......

  10. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Although administrative in nature, costs of information technology—computer hardware and software—needed... information, including job listing information, job skills information, and demand occupation information; and...) Developing systems and procedures, including information systems, required for these administrative......

  11. 20 CFR 645.235 - What types of activities are subject to the administrative cost limit on Welfare-to-Work grants?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Although administrative in nature, costs of information technology—computer hardware and software—needed... information, including job listing information, job skills information, and demand occupation information; and...) Developing systems and procedures, including information systems, required for these administrative......

  12. The application of EOQ and lead time crashing cost models in material with limited life time (Case study: CN-235 Aircraft at PT Dirgantara Indonesia)

    NASA Astrophysics Data System (ADS)

    Agustina Hidayat, Yosi; Ria Kasanah, Aprilia; Yudhistira, Titah

    2016-02-01

    PT. Dirgantara Indonesia, one of State Owned Enterprises engaging in the aerospace industry, targets to control 30% of world market for light and medium sized aircraft. One type of the aircrafts produced by PT. DI every year is CN-235. Currently, the cost of material procurement reaches 50% of the total cost of production. Material has a variety of characteristics, one of which is having a lifetime. The demand characteristic of the material with expiration for the CN-235 aircraft is deterministic. PT DI does not have any scientific background for its procurement of raw material policy. In addition, there are two methods of transportation used for delivering materials, i.e. by land and air. Each method has different lead time. Inventory policies used in this research are deterministic and probabilistic. Both deterministic and probabilistic single and multi-item inventory policies have order quantity, time to order, reorder point, and lead time as decision variables. The performance indicator for this research is total inventory cost. Inventory policy using the single item EOQ and considering expiration factor inventory results in a reduction in total costs up to 69.58% and multi item results in a decrease in total costs amounted to 71.16%. Inventory policy proposal using the model of a single item by considering expiration factor and lead time crashing cost results in a decrease in total costs amounted to 71.5% and multi item results in a decrease in total costs amounted to 71.62%. Subsequently, wasted expired materials, with the proposed models have been successfully decreased to 95%.

  13. Factors that influence small animal veterinarians' opinions and actions regarding cost of care and effects of economic limitations on patient care and outcome and professional career satisfaction and burnout.

    PubMed

    Kipperman, Barry S; Kass, Philip H; Rishniw, Mark

    2017-04-01

    OBJECTIVE To determine small animal veterinarians' opinions and actions regarding costs of care, obstacles to client education about veterinary care costs, and effects of economic limitations on patient care and outcome and professional career satisfaction and burnout. DESIGN Cross-sectional survey. SAMPLE 1,122 small animal practitioners in the United States and Canada. PROCEDURES An online survey was sent to 37,036 veterinarians. Respondents provided information regarding perceived effects of client awareness of costs and pet health insurance coverage on various aspects of practice, the influence of client economic limitations on professional satisfaction and burnout, and proposals for addressing those effects. RESULTS The majority (620/1,088 [57%]) of respondents indicated that client economic limitations affected their ability to provide the desired care for their patients on a daily basis. Approximately half (527/1,071 [49%]) of respondents reported a moderate-to-substantial level of burnout, and many cited client economic limitations as an important contributing factor to burnout. Only 31% and 23% of respondents routinely discussed veterinary costs and pet insurance, respectively, with clients before pets became ill, and lack of time was cited as a reason for forgoing those discussions. Most respondents felt improved client awareness of veterinary costs and pet health insurance would positively affect patient care and client and veterinarian satisfaction. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested most small animal practitioners believe the veterinary profession needs to take action at educational and organizational levels to inform pet owners and educate and train veterinary students and veterinarians about the costs of veterinary care.

  14. Nonlinear Hydrostatic Adjustment.

    NASA Astrophysics Data System (ADS)

    Bannon, Peter R.

    1996-12-01

    The final equilibrium state of Lamb's hydrostatic adjustment problem is found for finite amplitude heating. Lamb's problem consists of the response of a compressible atmosphere to an instantaneous, horizontally homogeneous heating. Results are presented for both isothermal and nonisothermal atmospheres.As in the linear problem, the fluid displacements are confined to the heated layer and to the region aloft with no displacement of the fluid below the heating. The region above the heating is displaced uniformly upward for heating and downward for cooling. The amplitudes of the displacements are larger for cooling than for warming.Examination of the energetics reveals that the fraction of the heat deposited into the acoustic modes increases linearly with the amplitude of the heating. This fraction is typically small (e.g., 0.06% for a uniform warming of 1 K) and is essentially independent of the lapse rate of the base-state atmosphere. In contrast a fixed fraction of the available energy generated by the heating goes into the acoustic modes. This fraction (e.g., 12% for a standard tropospheric lapse rate) agrees with the linear result and increases with increasing stability of the base-state atmosphere.The compressible results are compared to solutions using various forms of the soundproof equations. None of the soundproof equations predict the finite amplitude solutions accurately. However, in the small amplitude limit, only the equations for deep convection advanced by Dutton and Fichtl predict the thermodynamic state variables accurately for a nonisothermal base-state atmosphere.

  15. Inflation Adjustments for Defense Acquisition

    DTIC Science & Technology

    2014-10-01

    Harmon Daniel B. Levine Stanley A. Horowitz, Project Leader INSTITUTE FOR DEFENSE ANALYSES 4850 Mark Center Drive Alexandria, Virginia 22311-1882 Approved...T U T E F O R D E F E N S E A N A L Y S E S IDA Document D-5112 Inflation Adjustments for Defense Acquisition Bruce R. Harmon Daniel B. Levine...might do a better job? The focus of the study is on aircraft procurement. By way of terminology , “cost index,” “price index,” and “deflator” are used

  16. Cost and cost-effectiveness of multidrug-resistant tuberculosis treatment in Estonia and Russia.

    PubMed

    Floyd, Katherine; Hutubessy, Raymond; Kliiman, Kai; Centis, Rosella; Khurieva, Nina; Jakobowiak, Wieslaw; Danilovits, Manfred; Peremitin, Genadi; Keshavjee, Salmaan; Migliori, Giovanni Battista

    2012-07-01

    Evidence on the cost and cost-effectiveness of treatment of multidrug-resistant tuberculosis (MDR-TB) is limited, and no published data are available from former Soviet Union countries, where rates of MDR-TB are highest globally. We evaluated the cost and cost-effectiveness of MDR-TB treatment in Estonia and Russia (Tomsk Oblast), comparing cohorts enrolled on treatment according to World Health Organization (WHO) guidelines in 2001 and 2002 with cohorts treated in previous years. Costs were assessed from a health system perspective in 2003 US$; effects were measured as cures, deaths averted and disability-adjusted life-years (DALYs) averted. Cure rates when WHO guidelines were followed were 61% (90 out of 149) in Estonia and 76% (76 out of 100) in Tomsk Oblast, with a cost per patient treated of US$8,974 and US$10,088, respectively. Before WHO guidelines were followed, cure rates were 52% in Estonia and 15% in Tomsk Oblast; the cost per patient treated was US$4,729 and US$2,282, respectively. Drugs and hospitalisation accounted for 69-90% of total costs. The cost per DALY averted by treatment following WHO guidelines was US$579 (range US$297-US$902) in Estonia and US$429 (range US$302-US$546) in Tomsk Oblast. Treatment of patients with MDR-TB can be cost-effective, but requires substantial additional investment in tuberculosis control in priority countries.

  17. 13 CFR 107.855 - Interest rate ceiling and limitations on fees charged to Small Businesses (“Cost of Money”).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... you may charge more, do the following: (1) Choose a base rate for your Cost of Money computation. The base rate may be either the Debenture Rate currently in effect plus the applicable Charge determined.... (2) For a Loan, add 11 percentage points to the base rate; for a Debt Security, add 6...

  18. Semi-Global Matching with Self-Adjusting Penalties

    NASA Astrophysics Data System (ADS)

    Karkalou, E.; Stentoumis, C.; Karras, G.

    2017-02-01

    The demand for 3D models of various scales and precisions is strong for a wide range of applications, among which cultural heritage recording is particularly important and challenging. In this context, dense image matching is a fundamental task for processes which involve image-based reconstruction of 3D models. Despite the existence of commercial software, the need for complete and accurate results under different conditions, as well as for computational efficiency under a variety of hardware, has kept image-matching algorithms as one of the most active research topics. Semi-global matching (SGM) is among the most popular optimization algorithms due to its accuracy, computational efficiency, and simplicity. A challenging aspect in SGM implementation is the determination of smoothness constraints, i.e. penalties P1, P2 for disparity changes and discontinuities. In fact, penalty adjustment is needed for every particular stereo-pair and cost computation. In this work, a novel formulation of self-adjusting penalties is proposed: SGM penalties can be estimated solely from the statistical properties of the initial disparity space image. The proposed method of self-adjusting penalties (SGM-SAP) is evaluated using typical cost functions on stereo-pairs from the recent Middlebury dataset of interior scenes, as well as from the EPFL Herz-Jesu architectural scenes. Results are competitive against the original SGM estimates. The significant aspects of self-adjusting penalties are: (i) the time-consuming tuning process is avoided; (ii) SGM can be used in image collections with limited number of stereo-pairs; and (iii) no heuristic user intervention is needed.

  19. Adjustable speed drives: Applications and R&D needs

    SciTech Connect

    Stefanovic, V.R.

    1995-09-01

    The largest opportunity for the growth of adjustable speed drives (ASDs) during the next 5-6 years is in pump, fan and compressor (PFC) applications where a constant, fixed speed operation is converted to adjustable speed in order to realize energy savings. Inverter supplied induction motors are and will continue to be predominately used in these applications. Over the long term (10-15 years), the greatest ASD growth is expected in large volume consumer applications: first in hybrid electric vehicles (EVs) and in residential heating, ventilation and air-conditioning (HVAC). Both induction and a variety of AC Permanent Magnet motors are expected to be the dominant technology in this new field. The traditional ASD applications in industries which require adjustable speed (such as machine tools, robotics, steel rolling, extruders, paper mill finishing lines, etc.) offer a relatively limited potential for above average ASD growth since most of these applications have already converted to electronic speed control. As a result, ASD growth in this sector will essentially track the growth of the corresponding industries. If realized, both short and long term ASD growth opportunities will result in significant advancements of ASD technology, which will then substantially affect all other, more fragmented, ASD applications. In fact, any single large volume ASD application will serve as a catalyst for improving ASD characteristics in all other ASD applications with the same voltage rating. ASD cost and reliability (defined in the context of application compatibility) are the two most important factors which will determine whether the ASD growth opportunities are realized. Conversely, any technological improvement which carries a cost increase will be restricted to niche applications, at best. Consequently, future R & D efforts should be directed to secure reduction in ASD cost and improvement in ASD reliability. A specific action plan is outlined in this report.

  20. The role of anticipatory postural adjustments in interlimb coordination of coupled arm movements in the parasagittal plane: III. difference in the energy cost of postural actions during cyclic flexion-extension arm movements, ISO- and ANTI-directionally coupled.

    PubMed

    Esposti, Roberto; Limonta, Eloisa; Esposito, Fabio; Baldissera, Fausto G

    2013-11-01

    When oscillating the upper limbs together in the parasagittal plane, movements coordination is lower (i.e., variability of the interlimb relative phase is higher) in antidirectional (ANTI) than in isodirectional (ISO) coupling. In contrast, we previously observed that for arm movements in the horizontal plane, the coordination was worse in ISO than ANTI and the energetic cost of postural activities was higher in ISO. Having hypothesised that the higher postural cost was one factor responsible for the coordination deficit in horizontal ISO, we measured the oxygen uptake ([Formula: see text]) in parasagittal movements, expecting that in this case too, the postural cost is higher in the less-coordinated mode (ANTI). Breath-by-breath metabolic ([Formula: see text], [Formula: see text]) and cardiorespiratory (HR, [Formula: see text]) parameters were measured in seven participants, who performed cyclic flexions-extensions in the parasagittal plane with either one arm or both arms, in ISO or ANTI coupling and at 1.4, 2.2 and 2.6 Hz. In each condition, the intermittent exercise (12 s movement, 12 s rest) lasted 264 s. A force platform recorded the mechanical actions to the ground. The exercise metabolic cost ([Formula: see text]) was found to be significantly higher in parasagittal ANTI than ISO. The movement amplitude being equal in the two modes, the ANTI-ISO difference should be ascribed to postural activities. This would confirm that the less-coordinated coupling mode requires the higher postural effort in parasagittal movements too. When rising the movement frequency, [Formula: see text] increased and linearly correlated with the coordination loss. Comparison of parasagittal with horizontal movements showed that [Formula: see text] was lower in parasagittal ANTI than in horizontal ISO (the less-coordinated modes), while it was not different between parasagittal ISO and horizontal ANTI (the more-coordinated modes).

  1. 24 CFR 882.410 - Rent adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Owner is otherwise in compliance with the terms of the Lease and Contract. Subject to the foregoing... Annual Adjustment Factor by the base rents. However, if the amounts borrowed to finance the rehabilitation costs or to finance purchase of the property are subject to a variable rate or are...

  2. Remotely Adjustable Hydraulic Pump

    NASA Technical Reports Server (NTRS)

    Kouns, H. H.; Gardner, L. D.

    1987-01-01

    Outlet pressure adjusted to match varying loads. Electrohydraulic servo has positioned sleeve in leftmost position, adjusting outlet pressure to maximum value. Sleeve in equilibrium position, with control land covering control port. For lowest pressure setting, sleeve shifted toward right by increased pressure on sleeve shoulder from servovalve. Pump used in aircraft and robots, where hydraulic actuators repeatedly turned on and off, changing pump load frequently and over wide range.

  3. Adjustable Pitot Probe

    NASA Technical Reports Server (NTRS)

    Ashby, George C., Jr.; Robbins, W. Eugene; Horsley, Lewis A.

    1991-01-01

    Probe readily positionable in core of uniform flow in hypersonic wind tunnel. Formed of pair of mating cylindrical housings: transducer housing and pitot-tube housing. Pitot tube supported by adjustable wedge fairing attached to top of pitot-tube housing with semicircular foot. Probe adjusted both radially and circumferentially. In addition, pressure-sensing transducer cooled internally by water or other cooling fluid passing through annulus of cooling system.

  4. 76 FR 81295 - Cost Accounting Standards: Cost Accounting Standards 412 and 413-Cost Accounting Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... Accounting Standard (CAS) 412, ``Composition and Measurement of Pension Cost,'' and CAS 413, ``Adjustment and Allocation of Pension Cost.'' This revision will harmonize the measurement and period assignment of the... cost objectives in accordance with CAS, and the measurement and period assignment requirements...

  5. Weighted triangulation adjustment

    USGS Publications Warehouse

    Anderson, Walter L.

    1969-01-01

    The variation of coordinates method is employed to perform a weighted least squares adjustment of horizontal survey networks. Geodetic coordinates are required for each fixed and adjustable station. A preliminary inverse geodetic position computation is made for each observed line. Weights associated with each observed equation for direction, azimuth, and distance are applied in the formation of the normal equations in-the least squares adjustment. The number of normal equations that may be solved is twice the number of new stations and less than 150. When the normal equations are solved, shifts are produced at adjustable stations. Previously computed correction factors are applied to the shifts and a most probable geodetic position is found for each adjustable station. Pinal azimuths and distances are computed. These may be written onto magnetic tape for subsequent computation of state plane or grid coordinates. Input consists of punch cards containing project identification, program options, and position and observation information. Results listed include preliminary and final positions, residuals, observation equations, solution of the normal equations showing magnitudes of shifts, and a plot of each adjusted and fixed station. During processing, data sets containing irrecoverable errors are rejected and the type of error is listed. The computer resumes processing of additional data sets.. Other conditions cause warning-errors to be issued, and processing continues with the current data set.

  6. A new method for adjusting the lateral transfer hollow retroreflector

    NASA Astrophysics Data System (ADS)

    Ershov, Alexandr G.

    2013-05-01

    A new method for adjusting the lateral transfer hollow retroreflector is presented. It allows in a simple way to adjust the hollow retroreflectors with a lateral shifting. It enables to make the manufacturing process of adjustable lateral hollow retroreflectors easier and cheaper. The testing optical bed of this method is displayed. The evaluation of uncertainties and a limit value for this method are given.

  7. Recirculating valve lash adjuster

    SciTech Connect

    Stoody, R.R.

    1987-02-24

    This patent describes an internal combustion engine with a valve assembly of the type including overhead valves supported by a cylinder head for opening and closing movements in a substantially vertical direction and a rotatable overhead camshaft thereabove lubricated by engine oil pumped by an engine oil pump. A hydraulic lash adjuster with an internal reservoir therein is solely supplied with run-off lubricating oil from the camshaft which oil is pumped into the internal reservoir of the lash adjuster by self-pumping operation of the lash adjuster produced by lateral forces thereon by the rotative operation of the camshaft comprising: a housing of the lash adjuster including an axially extending bore therethrough with a lower wall means of the housing closing the lower end thereof; a first plunger member being closely slidably received in the bore of the housing and having wall means defining a fluid filled power chamber with the lower wall means of the housing; and a second plunger member of the lash adjuster having a portion being loosely slidably received and extending into the bore of the housing for reciprocation therein. Another portion extends upwardly from the housing to operatively receive alternating side-to-side force inputs from operation of the camshaft.

  8. 44 CFR 13.51 - Later disallowances and adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY GENERAL UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE... adjustments. The closeout of a grant does not affect: (a) The Federal agency's right to disallow costs...

  9. Psychological Adjustment and Homosexuality.

    ERIC Educational Resources Information Center

    Gonsiorek, John C.

    In this paper, the diverse literature bearing on the topic of homosexuality and psychological adjustment is critically reviewed and synthesized. The first chapter discusses the most crucial methodological issue in this area, the problem of sampling. The kinds of samples used to date are critically examined, and some suggestions for improved…

  10. Self Adjusting Sunglasses

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Corning Glass Works' Serengeti Driver sunglasses are unique in that their lenses self-adjust and filter light while suppressing glare. They eliminate more than 99% of the ultraviolet rays in sunlight. The frames are based on the NASA Anthropometric Source Book.

  11. Self adjusting inclinometer

    DOEpatents

    Hunter, Steven L.

    2002-01-01

    An inclinometer utilizing synchronous demodulation for high resolution and electronic offset adjustment provides a wide dynamic range without any moving components. A device encompassing a tiltmeter and accompanying electronic circuitry provides quasi-leveled tilt sensors that detect highly resolved tilt change without signal saturation.

  12. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND THORIUM PROCESSING SITES Reimbursement Criteria § 765.12 Inflation index adjustment procedures. (a)...

  13. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND THORIUM PROCESSING SITES Reimbursement Criteria § 765.12 Inflation index adjustment procedures. (a)...

  14. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND THORIUM PROCESSING SITES Reimbursement Criteria § 765.12 Inflation index adjustment procedures. (a)...

  15. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND THORIUM PROCESSING SITES Reimbursement Criteria § 765.12 Inflation index adjustment procedures. (a)...

  16. 10 CFR 765.12 - Inflation index adjustment procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Inflation index adjustment procedures. 765.12 Section 765.12 Energy DEPARTMENT OF ENERGY REIMBURSEMENT FOR COSTS OF REMEDIAL ACTION AT ACTIVE URANIUM AND THORIUM PROCESSING SITES Reimbursement Criteria § 765.12 Inflation index adjustment procedures. (a)...

  17. 10 CFR 436.22 - Adjusted internal rate of return.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Methodology and Procedures for Life Cycle Cost Analyses § 436.22 Adjusted internal rate of return. The adjusted internal rate of return is the overall rate of return on an energy or water conservation measure... yearly net savings in energy or water and non-fuel or non-water operation and maintenance...

  18. 10 CFR 436.22 - Adjusted internal rate of return.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Methodology and Procedures for Life Cycle Cost Analyses § 436.22 Adjusted internal rate of return. The adjusted internal rate of return is the overall rate of return on an energy or water conservation measure... yearly net savings in energy or water and non-fuel or non-water operation and maintenance...

  19. Statewide Implementation of Parenting with Love and Limits Among Youth with Co-Existing Internalizing and Externalizing Functional Impairments Reduces Return to Service Rates and Treatment Costs.

    PubMed

    Sterrett-Hong, Emma M; Karam, Eli; Kiaer, Lynn

    2017-01-24

    Many community mental health (CMH) systems contain inefficiencies, contributing to unmet need for services among youth. Using a quasi-experimental research design, we examined the implementation of an adapted structural-strategic family intervention, Parenting with Love and Limits, in a state CMH system to increase efficiency of services to youth with co-existing internalizing and externalizing functional impairments (PLL n = 296; Treatment-As-Usual n = 296; 54% male; 81% Caucasian). Youth receiving PLL experienced shorter treatment durations and returned to CMH services at significantly lower rates than youth receiving treatment-as-usual. They also demonstrated significant decreases in internalizing and externalizing symptoms over time. Findings lay the foundation for further examination of the role of an adapted structural-strategic family treatment in increasing the efficiency of CMH systems.

  20. 39 CFR 3010.14 - Contents of notice of rate adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DOMINANT PRODUCTS Rules for Rate Adjustments for Rates of General Applicability (Type 1-A and 1-B Rate... costs; (7) A discussion that demonstrates how the planned rate adjustments are designed to help...

  1. Cost characteristics of hospitals.

    PubMed

    Smet, Mike

    2002-09-01

    Modern hospitals are complex multi-product organisations. The analysis of a hospital's production and/or cost structure should therefore use the appropriate techniques. Flexible functional forms based on the neo-classical theory of the firm seem to be most suitable. Using neo-classical cost functions implicitly assumes minimisation of (variable) costs given that input prices and outputs are exogenous. Local and global properties of flexible functional forms and short-run versus long-run equilibrium are further issues that require thorough investigation. In order to put the results based on econometric estimations of cost functions in the right perspective, it is important to keep these considerations in mind when using flexible functional forms. The more recent studies seem to agree that hospitals generally do not operate in their long-run equilibrium (they tend to over-invest in capital (capacity and equipment)) and that it is therefore appropriate to estimate a short-run variable cost function. However, few studies explicitly take into account the implicit assumptions and restrictions embedded in the models they use. An alternative method to explain differences in costs uses management accounting techniques to identify the cost drivers of overhead costs. Related issues such as cost-shifting and cost-adjusting behaviour of hospitals and the influence of market structure on competition, prices and costs are also discussed shortly.

  2. Role of Osmotic Adjustment in Plant Productivity

    SciTech Connect

    Gebre, G.M.

    2001-01-11

    Successful implementation of short rotation woody crops requires that the selected species and clones be productive, drought tolerant, and pest resistant. Since water is one of the major limiting factors in poplar (Populus sp.) growth, there is little debate for the need of drought tolerant clones, except on the wettest of sites (e.g., lower Columbia River delta). Whether drought tolerance is compatible with productivity remains a debatable issue. Among the many mechanisms of drought tolerance, dehydration postponement involves the maintenance of high leaf water potential due to, for example, an adequate root system. This trait is compatible with productivity, but requires available soil moisture. When the plant leaf water potential and soil water content decline, the plant must be able to survive drought through dehydration tolerance mechanisms, such as low osmotic potential or osmotic adjustment. Osmotic adjustment and low osmotic potential are considered compatible with growth and yield because they aid in the maintenance of leaf turgor. However, it has been shown that turgor alone does not regulate cell expansion or stomatal conductance and, therefore, the role of osmotic adjustment is debated. Despite this finding, osmotic adjustment has been correlated with grain yield in agronomic crop species, and gene markers responsible for osmotic adjustment are being investigated to improve drought tolerance in productive progenies. Although osmotic adjustment and low osmotic potentials have been investigated in several forest tree species, few studies have investigated the relationship between osmotic adjustment and growth. Most of these studies have been limited to greenhouse or container-grown plants. Osmotic adjustment and rapid growth have been specifically associated in Populus and black spruce (Picea mariuna (Mill.) B.S.P.) progenies. We tested whether these relationships held under field conditions using several poplar clones. In a study of two hybrid poplar

  3. Dried tube specimens: a simple and cost-effective method for preparation of HIV proficiency testing panels and quality control materials for use in resource-limited settings.

    PubMed

    Parekh, Bharat S; Anyanwu, Juliana; Patel, Hetal; Downer, Marie; Kalou, Mireille; Gichimu, Catherine; Keipkerich, Bera Steven; Clement, Nelly; Omondi, Michael; Mayer, Oren; Ou, Chin-Yih; Nkengasong, John N

    2010-02-01

    HIV testing has rapidly expanded worldwide, but proficiency testing (PT) programs to monitor and improve the quality of testing are often lacking in resource-limited settings (RLS). Traditional PT programs and quality control reagents use serum or plasma specimens requiring stringent conditions for storage and transportation. A novel, simple and easy to use approach, based on dried tube specimens (DTS), was developed that can help monitor the quality of HIV antibody testing in RLS. DTS were prepared by drying 20 microl of specimen overnight at room temperature. The addition of a green dye (0.1%) made the DTS pellets visible without affecting the test results. Before testing, the DTS were rehydrated with 200 microl of PBS-Tween buffer. A panel of 303 DTS samples (135 HIV positive and 168 HIV negative) was evaluated with two rapid tests. Sensitivity and specificity with the Determine HIV-1/2 test were 99.3% and 99.4%, respectively, and with OraQuick were 98.5% and 100%, respectively. Stability studies showed that HIV-specific antibodies in the DTS specimens were stable at 4 degrees C and 25 degrees C for 4 weeks, with only marginal decline at 37 degrees C and 45 degrees C over 4 weeks. The DTS-based PT program was piloted successfully in 24 testing sites in Kenya. Results demonstrate that the DTS is a simple to use, practical method to prepare and distribute PT panels and quality control specimens to monitor HIV testing practices in RLS.

  4. An adjustable solar concentrator

    NASA Technical Reports Server (NTRS)

    Collins, E. R., Jr.

    1980-01-01

    Fixed cylindrical converging lenses followed by movable parabolic mirror focus solar energy on conventional linear collector. System is low cost and accomodates daily and seasonal movements of the sun. Mirrors may be moved using simple, low-power electrical motors.

  5. BMP COST ANALYSIS FOR SOURCE WATER PROTECTION

    EPA Science Inventory

    Cost equations are developed to estimate capital and operations and maintenance (O&M) for commonly used best management practices (BMPS). Total BMP volume and/or surface area is used to predict these costs. ENR construction cost index was used to adjust cost data to December 2000...

  6. 49 CFR 1139.3 - Cost study.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Cost study. 1139.3 Section 1139.3 Transportation... Commodities § 1139.3 Cost study. (a) The respondents shall submit a cost study. Highway Form B may be used for this purpose. Service unit-costs shall be developed for each individual study carrier, adjusted by...

  7. 49 CFR 1139.3 - Cost study.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Cost study. 1139.3 Section 1139.3 Transportation... Commodities § 1139.3 Cost study. (a) The respondents shall submit a cost study. Highway Form B may be used for this purpose. Service unit-costs shall be developed for each individual study carrier, adjusted by...

  8. 49 CFR 1139.3 - Cost study.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Cost study. 1139.3 Section 1139.3 Transportation... Commodities § 1139.3 Cost study. (a) The respondents shall submit a cost study. Highway Form B may be used for this purpose. Service unit-costs shall be developed for each individual study carrier, adjusted by...

  9. 49 CFR 1139.3 - Cost study.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Cost study. 1139.3 Section 1139.3 Transportation... Commodities § 1139.3 Cost study. (a) The respondents shall submit a cost study. Highway Form B may be used for this purpose. Service unit-costs shall be developed for each individual study carrier, adjusted by...

  10. 49 CFR 1139.3 - Cost study.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Cost study. 1139.3 Section 1139.3 Transportation... Commodities § 1139.3 Cost study. (a) The respondents shall submit a cost study. Highway Form B may be used for this purpose. Service unit-costs shall be developed for each individual study carrier, adjusted by...

  11. Adjustable Autonomy Testbed

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Schrenkenghost, Debra K.

    2001-01-01

    The Adjustable Autonomy Testbed (AAT) is a simulation-based testbed located in the Intelligent Systems Laboratory in the Automation, Robotics and Simulation Division at NASA Johnson Space Center. The purpose of the testbed is to support evaluation and validation of prototypes of adjustable autonomous agent software for control and fault management for complex systems. The AA T project has developed prototype adjustable autonomous agent software and human interfaces for cooperative fault management. This software builds on current autonomous agent technology by altering the architecture, components and interfaces for effective teamwork between autonomous systems and human experts. Autonomous agents include a planner, flexible executive, low level control and deductive model-based fault isolation. Adjustable autonomy is intended to increase the flexibility and effectiveness of fault management with an autonomous system. The test domain for this work is control of advanced life support systems for habitats for planetary exploration. The CONFIG hybrid discrete event simulation environment provides flexible and dynamically reconfigurable models of the behavior of components and fluids in the life support systems. Both discrete event and continuous (discrete time) simulation are supported, and flows and pressures are computed globally. This provides fast dynamic simulations of interacting hardware systems in closed loops that can be reconfigured during operations scenarios, producing complex cascading effects of operations and failures. Current object-oriented model libraries support modeling of fluid systems, and models have been developed of physico-chemical and biological subsystems for processing advanced life support gases. In FY01, water recovery system models will be developed.

  12. Precision adjustable stage

    DOEpatents

    Cutburth, Ronald W.; Silva, Leonard L.

    1988-01-01

    An improved mounting stage of the type used for the detection of laser beams is disclosed. A stage center block is mounted on each of two opposite sides by a pair of spaced ball bearing tracks which provide stability as well as simplicity. The use of the spaced ball bearing pairs in conjunction with an adjustment screw which also provides support eliminates extraneous stabilization components and permits maximization of the area of the center block laser transmission hole.

  13. The risk-adjusted vision beyond casemix (DRG) funding in Australia. International lessons in high complexity and capitation.

    PubMed

    Antioch, Kathryn M; Walsh, Michael K

    2004-06-01

    Hospitals throughout the world using funding based on diagnosis-related groups (DRG) have incurred substantial budgetary deficits, despite high efficiency. We identify the limitations of DRG funding that lack risk (severity) adjustment for State-wide referral services. Methods to risk adjust DRGs are instructive. The average price in casemix funding in the Australian State of Victoria is policy based, not benchmarked. Average cost weights are too low for high-complexity DRGs relating to State-wide referral services such as heart and lung transplantation and trauma. Risk-adjusted specified grants (RASG) are required for five high-complexity respiratory, cardiology and stroke DRGs incurring annual deficits of $3.6 million due to high casemix complexity and government under-funding despite high efficiency. Five stepwise linear regressions for each DRG excluded non-significant variables and assessed heteroskedasticity and multicollinearlity. Cost per patient was the dependent variable. Significant independent variables were age, length-of-stay outliers, number of disease types, diagnoses, procedures and emergency status. Diagnosis and procedure severity markers were identified. The methodology and the work of the State-wide Risk Adjustment Working Group can facilitate risk adjustment of DRGs State-wide and for Treasury negotiations for expenditure growth. The Alfred Hospital previously negotiated RASG of $14 million over 5 years for three trauma and chronic DRGs. Some chronic diseases require risk-adjusted capitation funding models for Australian Health Maintenance Organizations as an alternative to casemix funding. The use of Diagnostic Cost Groups can facilitate State and Federal government reform via new population-based risk adjusted funding models that measure health need.

  14. Can delivery systems use cost-effectiveness analysis to reduce healthcare costs and improve value?

    PubMed Central

    Savitz, Lucy A.; Savitz, Samuel T.

    2016-01-01

    Understanding costs and ensuring that we demonstrate value in healthcare is a foundational presumption as we transform the way we deliver and pay for healthcare in the U.S. With a focus on population health and payment reforms underway, there is increased pressure to examine cost-effectiveness in healthcare delivery. Cost-effectiveness analysis (CEA) is a type of economic analysis comparing the costs and effects (i.e. health outcomes) of two or more treatment options. The result is expressed as a ratio where the denominator is the gain in health from a measure (e.g. years of life or quality-adjusted years of life) and the numerator is the incremental cost associated with that health gain. For higher cost interventions, the lower the ratio of costs to effects, the higher the value. While CEA is not new, the approach continues to be refined with enhanced statistical techniques and standardized methods. This article describes the CEA approach and also contrasts it to optional approaches, in order for readers to fully appreciate caveats and concerns. CEA as an economic evaluation tool can be easily misused owing to inappropriate assumptions, over reliance, and misapplication. Twelve issues to be considered in using CEA results to drive healthcare delivery decision-making are summarized. Appropriately recognizing both the strengths and the limitations of CEA is necessary for informed resource allocation in achieving the maximum value for healthcare services provided. PMID:27830055

  15. 42 CFR 417.540 - Enrollment costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Enrollment costs. 417.540 Section 417.540 Public... PLANS Medicare Payment: Cost Basis § 417.540 Enrollment costs. (a) Principle. Enrollment costs are... of costs included. Enrollment costs include, but are not limited to, reasonable costs incurred...

  16. 42 CFR 417.540 - Enrollment costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Enrollment costs. 417.540 Section 417.540 Public... PLANS Medicare Payment: Cost Basis § 417.540 Enrollment costs. (a) Principle. Enrollment costs are... of costs included. Enrollment costs include, but are not limited to, reasonable costs incurred...

  17. Hard Suit With Adjustable Torso Length

    NASA Technical Reports Server (NTRS)

    Vykukal, Hubert C.

    1987-01-01

    Torso sizing rings allow single suit to fit variety of people. Sizing rings inserted between coupling rings of torso portion of hard suit. Number of rings chosen to fit torso length of suit to that of wearer. Rings mate with, and seal to, coupling rings and to each other. New adjustable-size concept with cost-saving feature applied to other suits not entirely constructed of "hard" materials, such as chemical defense suits and suits for industrial-hazard cleanup.

  18. Low Cost Vision Based Personal Mobile Mapping System

    NASA Astrophysics Data System (ADS)

    Amami, M. M.; Smith, M. J.; Kokkas, N.

    2014-03-01

    Mobile mapping systems (MMS) can be used for several purposes, such as transportation, highway infrastructure mapping and GIS data collecting. However, the acceptance of these systems is not wide spread and their use is still limited due the high cost and dependency on the Global Navigation Satellite System (GNSS). A low cost vision based personal MMS has been produced with an aim to overcome these limitations. The system has been designed to depend mainly on cameras and use of low cost GNSS and inertial sensors to provide a bundle adjustment solution with initial values. The system has the potential to be used indoor and outdoor. The system has been tested indoors and outdoors with different GPS coverage, surrounded features, and narrow and curvy paths. Tests show that the system is able to work in such environments providing 3D coordinates of better than 10 cm accuracy.

  19. 42 CFR 412.320 - Disproportionate share adjustment factor.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 412.320 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... System for Inpatient Hospital Capital Costs Basic Methodology for Determining the Federal Rate for Capital-Related Costs § 412.320 Disproportionate share adjustment factor. (a) Criteria for...

  20. 42 CFR 412.322 - Indirect medical education adjustment factor.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Payment System for Inpatient Hospital Capital Costs Basic Methodology for Determining the Federal Rate for Capital-Related Costs § 412.322 Indirect medical education adjustment factor. (a) Basic data. CMS... number of inpatient days in the acute inpatient area of the hospital by the number of days in the...

  1. Adjustable Reeds For Weaving

    NASA Technical Reports Server (NTRS)

    Farley, Gary L.

    1994-01-01

    Local characteristics of fabrics varied to suit special applications. Adjustable reed machinery proposed for use in weaving fabrics in various net shapes, widths, yarn spacings, and yarn angles. Locations of edges of fabric and configuration of warp and filling yarns varied along fabric to obtain specified properties. In machinery, reed wires mounted in groups on sliders, mounted on lengthwise rails in reed frame. Mechanisms incorporated to move sliders lengthwise, parallel to warp yarns, by sliding them along rails; move sliders crosswise by translating reed frame rails perpendicular to warp yarns; and crosswise by spreading reed rails within group. Profile of reed wires in group on each slider changed.

  2. Continuously adjustable Pulfrich spectacles

    NASA Astrophysics Data System (ADS)

    Jacobs, Ken; Karpf, Ron

    2011-03-01

    A number of Pulfrich 3-D movies and TV shows have been produced, but the standard implementation has inherent drawbacks. The movie and TV industries have correctly concluded that the standard Pulfrich 3-D implementation is not a useful 3-D technique. Continuously Adjustable Pulfrich Spectacles (CAPS) is a new implementation of the Pulfrich effect that allows any scene containing movement in a standard 2-D movie, which are most scenes, to be optionally viewed in 3-D using inexpensive viewing specs. Recent scientific results in the fields of human perception, optoelectronics, video compression and video format conversion are translated into a new implementation of Pulfrich 3- D. CAPS uses these results to continuously adjust to the movie so that the viewing spectacles always conform to the optical density that optimizes the Pulfrich stereoscopic illusion. CAPS instantly provides 3-D immersion to any moving scene in any 2-D movie. Without the glasses, the movie will appear as a normal 2-D image. CAPS work on any viewing device, and with any distribution medium. CAPS is appropriate for viewing Internet streamed movies in 3-D.

  3. Kinematic synthesis of adjustable robotic mechanisms

    NASA Astrophysics Data System (ADS)

    Chuenchom, Thatchai

    1993-01-01

    Conventional hard automation, such as a linkage-based or a cam-driven system, provides high speed capability and repeatability but not the flexibility required in many industrial applications. The conventional mechanisms, that are typically single-degree-of-freedom systems, are being increasingly replaced by multi-degree-of-freedom multi-actuators driven by logic controllers. Although this new trend in sophistication provides greatly enhanced flexibility, there are many instances where the flexibility needs are exaggerated and the associated complexity is unnecessary. Traditional mechanism-based hard automation, on the other hand, neither can fulfill multi-task requirements nor are cost-effective mainly due to lack of methods and tools to design-in flexibility. This dissertation attempts to bridge this technological gap by developing Adjustable Robotic Mechanisms (ARM's) or 'programmable mechanisms' as a middle ground between high speed hard automation and expensive serial jointed-arm robots. This research introduces the concept of adjustable robotic mechanisms towards cost-effective manufacturing automation. A generalized analytical synthesis technique has been developed to support the computational design of ARM's that lays the theoretical foundation for synthesis of adjustable mechanisms. The synthesis method developed in this dissertation, called generalized adjustable dyad and triad synthesis, advances the well-known Burmester theory in kinematics to a new level. While this method provides planar solutions, a novel patented scheme is utilized for converting prescribed three-dimensional motion specifications into sets of planar projections. This provides an analytical and a computational tool for designing adjustable mechanisms that satisfy multiple sets of three-dimensional motion specifications. Several design issues were addressed, including adjustable parameter identification, branching defect, and mechanical errors. An efficient mathematical scheme for

  4. Medicare Program; Hospital Inpatient Prospective Payment Systems for Acute Care Hospitals and the Long-Term Care Hospital Prospective Payment System and Policy Changes and Fiscal Year 2017 Rates; Quality Reporting Requirements for Specific Providers; Graduate Medical Education; Hospital Notification Procedures Applicable to Beneficiaries Receiving Observation Services; Technical Changes Relating to Costs to Organizations and Medicare Cost Reports; Finalization of Interim Final Rules With Comment Period on LTCH PPS Payments for Severe Wounds, Modifications of Limitations on Redesignation by the Medicare Geographic Classification Review Board, and Extensions of Payments to MDHs and Low-Volume Hospitals. Final rule.

    PubMed

    2016-08-22

    making technical corrections and changes to regulations relating to costs to related organizations and Medicare cost reports; we are providing notice of the closure of three teaching hospitals and the opportunity to apply for available GME resident slots under section 5506 of the Affordable Care Act. We are finalizing the provisions of interim final rules with comment period that relate to a temporary exception for certain wound care discharges from the application of the site neutral payment rate under the LTCH PPS for certain LTCHs; application of two judicial decisions relating to modifications of limitations on redesignation by the Medicare Geographic Classification Review Board; and legislative extensions of the Medicare-dependent, small rural hospital program and changes to the payment adjustment for low-volume hospitals.

  5. Veterans' Compensation Cost-of-Living Adjustment Act of 2009

    THOMAS, 111th Congress

    Rep. Kirkpatrick, Ann [D-AZ-1

    2009-03-16

    03/31/2009 Received in the Senate and Read twice and referred to the Committee on Veterans' Affairs. (All Actions) Notes: For further action, see S.407, which became Public Law 111-37 on 6/30/2009. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  6. Veterans' Compensation Cost-of-Living Adjustment Act of 2012

    THOMAS, 112th Congress

    Sen. Tester, Jon [D-MT

    2012-03-29

    09/12/2012 Committee on Veterans' Affairs. Ordered to be reported without amendment favorably. (All Actions) Notes: For further action, see H.R.4114, which became Public Law 112-198 on 11/27/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. Veterans' Compensation Cost-of-Living Adjustment Act of 2010

    THOMAS, 111th Congress

    Sen. Akaka, Daniel K. [D-HI

    2010-03-11

    09/22/2010 Returned to the Calendar. Calendar No. 550. (consideration: CR S7364) (All Actions) Notes: For further action, see H.R.4667, which became Public Law 111-247 on 9/30/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  8. Veterans' Compensation Cost-of-Living Adjustment Act of 2011

    THOMAS, 112th Congress

    Rep. Runyan, Jon [R-NJ-3

    2011-04-06

    05/24/2011 Received in the Senate and Read twice and referred to the Committee on Veterans' Affairs. (All Actions) Notes: For further action, see S.894, which became Public Law 112-53 on 11/9/2011. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  9. 78 FR 78508 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ....1 386.2 2 FUEL 22.4 399.6 377.9 3 MATERIALS AND SUPPLIES 4.9 261.4 265.9 4 EQUIPMENT RENTS 5.6 207.7... EQUIPMENT RENTS 5.6 208.0 207.6 5 DEPRECIATION 11.5 218.9 217.8 6 INTEREST 2.3 87.3 87.3 7 OTHER ITEMS...

  10. Veterans' Compensation Cost-of-Living Adjustment Act of 2014

    THOMAS, 113th Congress

    Rep. Runyan, Jon [R-NJ-3

    2014-02-26

    03/07/2014 Referred to the Subcommittee on Disability Assistance and Memorial Affairs. (All Actions) Notes: For further action, see S.2258, which became Public Law 113-181 on 9/26/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  11. Veterans' Compensation Cost-of-Living Adjustment Act of 2013

    THOMAS, 113th Congress

    Rep. Runyan, Jon [R-NJ-3

    2013-02-06

    04/25/2013 Forwarded by Subcommittee to Full Committee by Voice Vote . (All Actions) Notes: For further action, see S.893, which became Public Law 113-52 on 11/21/2013. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  12. FHA Multifamily Loan Limit Adjustment Act of 2009

    THOMAS, 111th Congress

    Rep. Weiner, Anthony D. [D-NY-9

    2009-07-31

    09/16/2009 Received in the Senate and Read twice and referred to the Committee on Banking, Housing, and Urban Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  13. Adjusting alloy compositions for selected properties in temperature limited heaters

    DOEpatents

    Brady; Michael Patrick , Horton, Jr.; Joseph Arno , Vitek; John Michael

    2010-03-23

    Heaters for treating a subsurface formation are described herein. Such heaters can be obtained by using the systems and methods described herein. The heater includes a heater section including iron, cobalt, and carbon. The heater section has a Curie temperature less than a phase transformation temperature. The Curie temperature is at least 740.degree. C. The heater section provides, when time varying current is applied to the heater section, an electrical resistance.

  14. 26 CFR 1.6425-3 - Allowance of adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... may correct any mathematical error appearing on the application, and it may likewise make any...) Limitation. No application under section 6425 shall be allowed unless the amount of the adjustment is (1) at... Revenue Service shall act upon an application for an adjustment of overpayment of estimated income...

  15. 26 CFR 1.6425-3 - Allowance of adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... may correct any mathematical error appearing on the application, and it may likewise make any...) Limitation. No application under section 6425 shall be allowed unless the amount of the adjustment is (1) at... Revenue Service shall act upon an application for an adjustment of overpayment of estimated income...

  16. 26 CFR 1.6425-3 - Allowance of adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... may correct any mathematical error appearing on the application, and it may likewise make any...) Limitation. No application under section 6425 shall be allowed unless the amount of the adjustment is (1) at... Revenue Service shall act upon an application for an adjustment of overpayment of estimated income...

  17. 26 CFR 1.6425-3 - Allowance of adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... may correct any mathematical error appearing on the application, and it may likewise make any...) Limitation. No application under section 6425 shall be allowed unless the amount of the adjustment is (1) at... Revenue Service shall act upon an application for an adjustment of overpayment of estimated income...

  18. 47 CFR 1.1117 - Adjustments to charges.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (1) The fees will be adjusted by the Commission to reflect the percentage change in the Consumer Price Index for all Urban Consumers (CPI-U) from the date of enactment of the authorizing legislation... modifications will be limited to correction of arithmetical errors made during an adjustment cycle....

  19. Enteric coating of mycophenolate reduces dosage adjustments.

    PubMed

    Brister, K; Yau, C L; Slakey, D

    2009-06-01

    Mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS) are bioequivalent. However, the effectiveness of MMF may be limited by gastrointestinal (GI) side effects. This study assessed the relationship between the number of medication dosage adjustments and posttransplantation side effects. In a review of 109 kidney transplant patients, 65 initially received MMF and 44 initially received EC-MPS. The incidences of patient-reported GI complications were significantly different: MMF 45.5% vs EC-MPS 35.3% (P = .0194). The proportions of patients requiring dosage adjustment due to GI complications were MMF 5.9% and EC-MPS 2.3% (P < .0001). Patients receiving MMF were more likely to experience GI complications resulting in dosage adjustment (odds ratio = 9.9; P = .0306). The incidences of acute rejection, cytomegalovirus (CMV), and leukopenia resulting in dosage adjustment were not significantly different. Patients receiving MMF required more immunosuppressive medication adjustments, which may complicate care and decrease overall compliance.

  20. A propensity score approach to estimating the cost-effectiveness of medical therapies from observational data.

    PubMed

    Mitra, Nandita; Indurkhya, Alka

    2005-08-01

    Health summary measures are commonly used by policy makers to help make decisions on the allocation of societal resources for competing medical treatments. The net monetary benefit is a health summary measure that overcomes the statistical limitations of a popular measure namely, the cost-effectiveness ratio. We introduce a linear model framework to estimate propensity score adjusted net monetary benefit. This method provides less biased estimates in the presence of significant differences in baseline measures and demographic characteristics between treatment groups in quasi-randomized or observational studies. Simulation studies were conducted to better understand the utility of propensity score adjusted estimates of net monetary benefits when important covariates are unobserved. The results indicated that the propensity score adjusted net monetary benefit provides a robust measure of cost-effectiveness in the presence of hidden bias. The methods are illustrated using data from SEER-Medicare for the treatment of bladder cancer.

  1. 42 CFR 412.101 - Special treatment: Inpatient hospital payment adjustment for low-volume hospitals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... adjustment for low-volume hospitals. 412.101 Section 412.101 Public Health CENTERS FOR MEDICARE & MEDICAID... Inpatient Operating Costs § 412.101 Special treatment: Inpatient hospital payment adjustment for low-volume... payment to a qualifying hospital for the higher incremental costs associated with a low volume...

  2. Delay Adjusted Incidence

    Cancer.gov

    This Infographic shows the National Cancer Institute SEER Incidence Trends. The graphs show the Average Annual Percent Change (AAPC) 2002-2011. For Men, Thyroid: 5.3*,Liver & IBD: 3.6*, Melanoma: 2.3*, Kidney: 2.0*, Myeloma: 1.9*, Pancreas: 1.2*, Leukemia: 0.9*, Oral Cavity: 0.5, Non-Hodgkin Lymphoma: 0.3*, Esophagus: -0.1, Brain & ONS: -0.2*, Bladder: -0.6*, All Sites: -1.1*, Stomach: -1.7*, Larynx: -1.9*, Prostate: -2.1*, Lung & Bronchus: -2.4*, and Colon & Rectum: -3/0*. For Women, Thyroid: 5.8*, Liver & IBD: 2.9*, Myeloma: 1.8*, Kidney: 1.6*, Melanoma: 1.5, Corpus & Uterus: 1.3*, Pancreas: 1.1*, Leukemia: 0.6*, Brain & ONS: 0, Non-Hodgkin Lymphoma: -0.1, All Sites: -0.1, Breast: -0.3, Stomach: -0.7*, Oral Cavity: -0.7*, Bladder: -0.9*, Ovary: -0.9*, Lung & Bronchus: -1.0*, Cervix: -2.4*, and Colon & Rectum: -2.7*. * AAPC is significantly different from zero (p<.05). Rates were adjusted for reporting delay in the registry. www.cancer.gov Source: Special section of the Annual Report to the Nation on the Status of Cancer, 1975-2011.

  3. 50 CFR 622.440 - Adjustment of management measures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ATLANTIC Reef Fish Fishery of Puerto Rico and the U.S. Virgin Islands § 622.440 Adjustment of management... stock size threshold (MSST), overfishing limit (OFL), acceptable biological catch (ABC) control...

  4. 50 CFR 622.440 - Adjustment of management measures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ATLANTIC Reef Fish Fishery of Puerto Rico and the U.S. Virgin Islands § 622.440 Adjustment of management... stock size threshold (MSST), overfishing limit (OFL), acceptable biological catch (ABC) control...

  5. Corps of Engineers considers adjustable-speed generation

    SciTech Connect

    Not Available

    1993-04-01

    The US Army Corps of Engineers and the Bonneville Power Administration recently commissioned a study to assess the various aspects of adjustable-speed generation (also called variable-speed generation). Electronic Power Conditioning Inc., of Corvallis, Oregon, studied the cost, efficiency, and other operating implications of installing the necessary hardware to enable adjustable-speed generation at four Corps hydroelectric plants on the lower Snake River (Ice Harbor, Lower Monumental, Little Goose, and Lower Granite). Results of the study indicate that, while costly, five adjustable-speed options could be installed and operated on a practical basis. The Corps initiated the study to determine the cost for adding adjustable-speed generation at the four projects to improve fish survival. The Northwest Power Planning Council currently is considering proposals to modify operating procedures for hydroelectric projects on the Columbia River and its tributaries, including seasonal adjustments of pool levels behind dams to flush fish through the river system more rapidly. However, dropping pool levels significantly below normal levels may cause a loss in generating efficiency and a corresponding increase in fish mortality. Adjustable-speed generation is seen as a method for solving both problems

  6. Cost goals

    NASA Technical Reports Server (NTRS)

    Hoag, J.

    1981-01-01

    Cost goal activities for the point focusing parabolic dish program are reported. Cost goals involve three tasks: (1) determination of the value of the dish systems to potential users; (2) the cost targets of the dish system are set out; (3) the value side and cost side are integrated to provide information concerning the potential size of the market for parabolic dishes. The latter two activities are emphasized.

  7. Tracking Costs

    ERIC Educational Resources Information Center

    Erickson, Paul W.

    2010-01-01

    Even though there's been a slight reprieve in energy costs, the reality is that the cost of non-renewable energy is increasing, and state education budgets are shrinking. One way to keep energy and operations costs from overshadowing education budgets is to develop a 10-year energy audit plan to eliminate waste. First, facility managers should…

  8. Capitation pricing: Adjusting for prior utilization and physician discretion

    PubMed Central

    Anderson, Gerard F.; Cantor, Joel C.; Steinberg, Earl P.; Holloway, James

    1986-01-01

    As the number of Medicare beneficiaries receiving care under at-risk capitation arrangements increases, the method for setting payment rates will come under increasing scrutiny. A number of modifications to the current adjusted average per capita cost (AAPCC) methodology have been proposed, including an adjustment for prior utilization. In this article, we propose use of a utilization adjustment that includes only hospitalizations involving low or moderate physician discretion in the decision to hospitalize. This modification avoids discrimination against capitated systems that prevent certain discretionary admissions. The model also explains more of the variance in per capita expenditures than does the current AAPCC. PMID:10312010

  9. Understanding DALYs (disability-adjusted life years).

    PubMed

    Murray, C J; Acharya, A K

    1997-12-01

    The measurement unit disability-adjusted life years (DALYs), used in recent years to quantify the burden of diseases, injuries and risk factors on human populations, is grounded on cogent economic and ethical principles and can guide policies toward delivering more cost-effective and equitable health care. DALYs follow from a fairness principle that treats 'like as like' within an information set comprising the health conditions of individuals, differentiated solely by age and sex. The particular health state weights used to account for non-fatal health outcomes are derived through the application of various forms of the person trade-off.

  10. Transfer and Evaluation of an Automated, Low-Cost Real-Time Reverse Transcription-PCR Test for Diagnosis and Monitoring of Human Immunodeficiency Virus Type 1 Infection in a West African Resource-Limited Setting

    PubMed Central

    Rouet, Francois; Ekouevi, Didier K.; Chaix, Marie-Laure; Burgard, Marianne; Inwoley, Andre; Tony, Thomas D'Aquin; Danel, Christine; Anglaret, Xavier; Leroy, Valeriane; Msellati, Philippe; Dabis, Francois; Rouzioux, Christine

    2005-01-01

    There is an urgent need for low-cost human immunodeficiency virus type 1 (HIV-1) viral load (VL) monitoring technologies in resource-limited settings. An automated TaqMan real-time reverse transcription-PCR (RT-PCR) assay was transferred to the laboratory of the Centre de Diagnostic et de Recherches sur le SIDA, Abidjan, Côte d'Ivoire, and assessed for HIV-1 RNA VL testing in 806 plasma samples collected within four ANRS research programs. The detection threshold and reproducibility of the assay were first determined. The quantitative results obtained with this assay were compared with two commercial HIV-1 RNA kits (the Versant version 3.0 and Monitor version 1.5 assays) in specimens harboring mainly the circulating recombinant form 02 strain (CRF02). The clinical evaluation of this test was done in different situations including the early diagnosis of pediatric infection and the monitoring of antiretroviral-treated patients. The quantification limit of our method was 300 copies/ml. The HIV-1 RNA values obtained by real-time PCR assay were highly correlated with those obtained by the Versant kit (r = 0.901; P < 0.001) and the Monitor test (r = 0.856; P < 0.001) and homogeneously distributed according to HIV-1 genotypes. For the early diagnosis of pediatric HIV-1 infection, the sensitivity and specificity of the real-time PCR assay were both 100% (95% confidence intervals of 93.7 to 100.0 and 98.3 to 100.0, respectively), compared to the Versant results. Following initiation of antiretroviral treatment, the kinetics of HIV-1 RNA levels were very comparable, with a similar proportion of adults and children below the detection limit during follow-up with our technique and the Versant assay. The TaqMan real-time PCR ($12 per test) is now routinely used to monitor HIV-1 infection in our laboratory. This technology should be further evaluated in limited-resource countries where strains other than CRF02 are prevalent. PMID:15956387

  11. Cost optimization in anaesthesia.

    PubMed

    Bauer, M; Bach, A; Martin, E; Böttiger, B W

    2001-04-01

    As a result of the progress which has been made in medicine and technology and the increase in morbidity associated this demographic development, the need and thus the costs for medical care have increased as well. The financial resources which are available for medical care, however, are still limited and hence the funds which are available must be distributed more efficiently. Cost optimisation measures can help make better use of the profitability reserves in hospitals. The authors show how costs can be optimised in the anaesthesiology department of a clinic. Pharmacoeconomic evaluation of the new inhalation anaesthetics shows an example of how the cost structures in anaesthesia can be made more obvious and potential ways savings be implemented. To reduce material and personnel costs, a more rational means of internal process management is presented. According to cost-effectiveness analysis, medications are not divided into the categories inexpensive and expensive but rather cost-effective or non-cost-effective. By selecting a cost-effective drug it is possible to reduce cost at a hospital. For example, sevoflurane at a fresh gas flow of below 3 l/min has been shown to be a cost-effective inhalation anaesthetic which, in terms of the economics, is also superior to intravenous anaesthesia with propofol. In addition to these measures of reducing material costs, other examples are given of how personnel costs can be reduced by optimising work procedures: e.g. effective operating theatre co-ordination, short switchover times by overlapping anaesthesia induction and the use of multifunctional personnel. The gain in productivity which is a result of these measures can positively affect profits, and by optimising the organisation of procedures to shorten the times required to carry out a procedure, costs can be reduced.

  12. Adjusted Clinical Groups: Predictive Accuracy for Medicaid Enrollees in Three States

    PubMed Central

    Adams, E. Kathleen; Bronstein, Janet M.; Raskind-Hood, Cheryl

    2002-01-01

    Actuarial split-sample methods were used to assess predictive accuracy of adjusted clinical groups (ACGs) for Medicaid enrollees in Georgia, Mississippi (lagging in managed care penetration), and California. Accuracy for two non-random groups—high-cost and located in urban poor areas—was assessed. Measures for random groups were derived with and without short-term enrollees to assess the effect of turnover on predictive accuracy. ACGs improved predictive accuracy for high-cost conditions in all States, but did so only for those in Georgia's poorest urban areas. Higher and more unpredictable expenses of short-term enrollees moderated the predictive power of ACGs. This limitation was significant in Mississippi due in part, to that State's very high proportion of short-term enrollees. PMID:12545598

  13. Economics of mycotoxins: evaluating costs to society and cost-effectiveness of interventions.

    PubMed

    2012-01-01

    The economic impacts of mycotoxins to human society can be thought of in two ways: (i) the direct market costs associated with lost trade or reduced revenues due to contaminated food or feed, and (ii) the human health losses from adverse effects associated with mycotoxin consumption. Losses related to markets occur within systems in which mycotoxins are being monitored in the food and feed supply. Food that has mycotoxin levels above a particular maximum allowable level is either rejected outright for sale or sold at a lower price for a different use. Such transactions can take place at local levels or at the level of trade among countries. Sometimes this can result in heavy economic losses for food producers, but the benefit of such monitoring systems is a lower risk of mycotoxins in the food supply. Losses related to health occur when mycotoxins are present in food at levels that can cause illness. In developed countries, such losses are often measured in terms of cost of illness; around the world, such losses are more frequently measured in terms of disability-adjusted life years (DALYs). It is also useful to assess the economics of interventions to reduce mycotoxins and their attendant health effects; the relative effectiveness of public health interventions can be assessed by estimating quality-adjusted life years (QALYs) associated with each intervention. Cost-effectiveness assessment can be conducted to compare the cost of implementing the intervention with the resulting benefits, in terms of either improved markets or improved human health. Aside from cost-effectiveness, however, it is also important to assess the technical feasibility of interventions, particularly in low-income countries, where funds and infrastructures are limited.

  14. Structural adjustment and drought in Zambia.

    PubMed

    Mulwanda, M

    1995-06-01

    While drought is not uncommon in Zambia, the country is now facing the worst drought in history. The monetary and social costs will be enormous. Although it is too early to measure the economic and social costs of the drought on Zambia, it is obvious that the impact is catastrophic on a country whose economy is under pressure. The drought will affect the structural adjustment programme (SAP) unveiled by the new government which has embraced the market economy. The country has imported, and will continue to import, large quantities of maize and other foodstuffs, a situation likely to strain the balance of payments. Earlier targets with regard to export earnings, reductions in the budget deficit, and GDP growth as contained in the Policy Framework Paper (PFP) are no longer attainable due to the effects of the drought.

  15. Spousal Adjustment to Myocardial Infarction.

    ERIC Educational Resources Information Center

    Ziglar, Elisa J.

    This paper reviews the literature on the stresses and coping strategies of spouses of patients with myocardial infarction (MI). It attempts to identify specific problem areas of adjustment for the spouse and to explore the effects of spousal adjustment on patient recovery. Chapter one provides an overview of the importance in examining the…

  16. 7 CFR 701.23 - Eligible costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....27. (b) Eligible costs shall be limited as follows: (1) Costs for use of personal equipment shall be limited to those incurred beyond the normal operation of the farm or ranch. (2) Costs for personal labor shall be limited to personal labor not normally required in the operation of the farm or ranch....

  17. 45 CFR 1183.22 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Allowable costs. 1183.22 Section 1183.22 Public....22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable costs in...

  18. 45 CFR 1157.22 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Allowable costs. 1157.22 Section 1157.22 Public... Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable costs in the form...

  19. 21 CFR 1403.22 - Allowable costs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Allowable costs. 1403.22 Section 1403.22 Food and....22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable costs in...

  20. 50 CFR 85.41 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Allowable costs. 85.41 Section 85.41... Use/Acceptance of Funds § 85.41 Allowable costs. (a) Allowable grant costs are limited to those costs... applicable Federal cost principles in 43 CFR 12.60(b). Purchase of informational signs, program signs,...

  1. 45 CFR 1174.22 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Allowable costs. 1174.22 Section 1174.22 Public....22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable costs in...

  2. 34 CFR 80.22 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Allowable costs. 80.22 Section 80.22 Education Office... Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable costs in the form...

  3. 15 CFR 24.22 - Allowable costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Allowable costs. 24.22 Section 24.22... Administration § 24.22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable costs in...

  4. 50 CFR 37.46 - Cost reimbursement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Cost reimbursement. 37.46 Section 37.46... NATIONAL WILDLIFE REFUGE, ALASKA General Administration § 37.46 Cost reimbursement. (a) Each applicant for... actual costs incurred, including, but not limited to, its direct costs and indirect costs as...

  5. 34 CFR 80.22 - Allowable costs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Allowable costs. 80.22 Section 80.22 Education Office... Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable costs in the form...

  6. Assessing the utility of statistical adjustments for imperfect detection in tropical conservation science

    PubMed Central

    Banks-Leite, Cristina; Pardini, Renata; Boscolo, Danilo; Cassano, Camila Righetto; Püttker, Thomas; Barros, Camila Santos; Barlow, Jos

    2014-01-01

    1. In recent years, there has been a fast development of models that adjust for imperfect detection. These models have revolutionized the analysis of field data, and their use has repeatedly demonstrated the importance of sampling design and data quality. There are, however, several practical limitations associated with the use of detectability models which restrict their relevance to tropical conservation science. 2. We outline the main advantages of detectability models, before examining their limitations associated with their applicability to the analysis of tropical communities, rare species and large-scale data sets. Finally, we discuss whether detection probability needs to be controlled before and/or after data collection. 3. Models that adjust for imperfect detection allow ecologists to assess data quality by estimating uncertainty and to obtain adjusted ecological estimates of populations and communities. Importantly, these models have allowed informed decisions to be made about the conservation and management of target species. 4. Data requirements for obtaining unadjusted estimates are substantially lower than for detectability-adjusted estimates, which require relatively high detection/recapture probabilities and a number of repeated surveys at each location. These requirements can be difficult to meet in large-scale environmental studies where high levels of spatial replication are needed, or in the tropics where communities are composed of many naturally rare species. However, while imperfect detection can only be adjusted statistically, covariates of detection probability can also be controlled through study design. Using three study cases where we controlled for covariates of detection probability through sampling design, we show that the variation in unadjusted ecological estimates from nearly 100 species was qualitatively the same as that obtained from adjusted estimates. Finally, we discuss that the decision as to whether one should control for

  7. 42 CFR 412.84 - Payment for extraordinarily high-cost cases (cost outliers).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES... operating and capital costs of the discharge on the billed charges for covered inpatient services adjusted by the cost to charge ratios applicable to operating and capital costs, respectively, as described...

  8. Precision Adjustable Liquid Regulator (ALR)

    NASA Astrophysics Data System (ADS)

    Meinhold, R.; Parker, M.

    2004-10-01

    A passive mechanical regulator has been developed for the control of fuel or oxidizer flow to a 450N class bipropellant engine for use on commercial and interplanetary spacecraft. There are several potential benefits to the propulsion system, depending on mission requirements and spacecraft design. This system design enables more precise control of main engine mixture ratio and inlet pressure, and simplifies the pressurization system by transferring the function of main engine flow rate control from the pressurization/propellant tank assemblies, to a single component, the ALR. This design can also reduce the thermal control requirements on the propellant tanks, avoid costly Qualification testing of biprop engines for missions with more stringent requirements, and reduce the overall propulsion system mass and power usage. In order to realize these benefits, the ALR must meet stringent design requirements. The main advantage of this regulator over other units available in the market is that it can regulate about its nominal set point to within +/-0.85%, and change its regulation set point in flight +/-4% about that nominal point. The set point change is handled actively via a stepper motor driven actuator, which converts rotary into linear motion to affect the spring preload acting on the regulator. Once adjusted to a particular set point, the actuator remains in its final position unpowered, and the regulator passively maintains outlet pressure. The very precise outlet regulation pressure is possible due to new technology developed by Moog, Inc. which reduces typical regulator mechanical hysteresis to near zero. The ALR requirements specified an outlet pressure set point range from 225 to 255 psi, and equivalent water flow rates required were in the 0.17 lb/sec range. The regulation output pressure is maintained at +/-2 psi about the set point from a P (delta or differential pressure) of 20 to over 100 psid. Maximum upstream system pressure was specified at 320 psi

  9. Cost-Effectiveness of Preventive Interventions to Reduce Alcohol Consumption in Denmark

    PubMed Central

    Holm, Astrid Ledgaard; Veerman, Lennert; Cobiac, Linda; Ekholm, Ola; Diderichsen, Finn

    2014-01-01

    Introduction Excessive alcohol consumption increases the risk of many diseases and injuries, and the Global Burden of Disease 2010 study estimated that 6% of the burden of disease in Denmark is due to alcohol consumption. Alcohol consumption thus places a considerable economic burden on society. Methods We analysed the cost-effectiveness of six interventions aimed at preventing alcohol abuse in the adult Danish population: 30% increased taxation, increased minimum legal drinking age, advertisement bans, limited hours of retail sales, and brief and longer individual interventions. Potential health effects were evaluated as changes in incidence, prevalence and mortality of alcohol-related diseases and injuries. Net costs were calculated as the sum of intervention costs and cost offsets related to treatment of alcohol-related outcomes, based on health care costs from Danish national registers. Cost-effectiveness was evaluated by calculating incremental cost-effectiveness ratios (ICERs) for each intervention. We also created an intervention pathway to determine the optimal sequence of interventions and their combined effects. Results Three of the analysed interventions (advertising bans, limited hours of retail sales and taxation) were cost-saving, and the remaining three interventions were all cost-effective. Net costs varied from € -17 million per year for advertisement ban to € 8 million for longer individual intervention. Effectiveness varied from 115 disability-adjusted life years (DALY) per year for minimum legal drinking age to 2,900 DALY for advertisement ban. The total annual effect if all interventions were implemented would be 7,300 DALY, with a net cost of € -30 million. Conclusion Our results show that interventions targeting the whole population were more effective than individual-focused interventions. A ban on alcohol advertising, limited hours of retail sale and increased taxation had the highest probability of being cost-saving and should thus

  10. Using propensity scores to estimate the cost-effectiveness of medical therapies.

    PubMed

    Indurkhya, Alka; Mitra, Nandita; Schrag, Deborah

    2006-05-15

    The cost-effectiveness ratio is a popular statistic that is used by policy makers to decide which programs are cost-effective in the public health sector. Recently, the net monetary benefit has been proposed as an alternative statistical summary measure to overcome the limitations associated with the cost-effectiveness ratio. Research on using the net monetary benefit to assess the cost-effectiveness of therapies in non-randomized studies has yet to be done. Propensity scores are useful in estimating adjusted effectiveness of programs that have non-randomized or quasi-experimental designs. This article introduces the use of propensity score adjustment in cost-effectiveness analyses to estimate net monetary benefits for non-randomized studies. The uncertainty associated with the net monetary benefit estimate is evaluated using cost-effectiveness acceptability curves. Our method is illustrated by applying it to SEER-Medicare data for muscle invasive bladder cancer to determine the most cost-effective treatment protocol.

  11. 48 CFR 652.216-71 - Price Adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for price adjustment shall present data reflecting: (1) The exchange rate in effect on the date of the contractor's proposal that was accepted for the basic contract; and (2) The current exchange rate and its... exchange rate gains. (e) Only direct cost changes mandated by enacted laws shall be considered...

  12. 48 CFR 652.216-71 - Price Adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... for price adjustment shall present data reflecting: (1) The exchange rate in effect on the date of the contractor's proposal that was accepted for the basic contract; and (2) The current exchange rate and its... exchange rate gains. (e) Only direct cost changes mandated by enacted laws shall be considered...

  13. 48 CFR 652.216-71 - Price Adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for price adjustment shall present data reflecting: (1) The exchange rate in effect on the date of the contractor's proposal that was accepted for the basic contract; and (2) The current exchange rate and its... exchange rate gains. (e) Only direct cost changes mandated by enacted laws shall be considered...

  14. 48 CFR 652.216-71 - Price Adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... for price adjustment shall present data reflecting: (1) The exchange rate in effect on the date of the contractor's proposal that was accepted for the basic contract; and (2) The current exchange rate and its... exchange rate gains. (e) Only direct cost changes mandated by enacted laws shall be considered...

  15. 48 CFR 652.216-71 - Price Adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for price adjustment shall present data reflecting: (1) The exchange rate in effect on the date of the contractor's proposal that was accepted for the basic contract; and (2) The current exchange rate and its... exchange rate gains. (e) Only direct cost changes mandated by enacted laws shall be considered...

  16. 18 CFR 154.403 - Periodic rate adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Where the costs, revenues, rates, quantities, indices, load factors, percentages, or other numbers used... filing. (vi) Where a number is derived from another number by applying a load factor, percentage, or other adjusting factor not referenced in paragraph (d)(1)(i) of this section, include workpapers and...

  17. 18 CFR 154.403 - Periodic rate adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Where the costs, revenues, rates, quantities, indices, load factors, percentages, or other numbers used... filing. (vi) Where a number is derived from another number by applying a load factor, percentage, or other adjusting factor not referenced in paragraph (d)(1)(i) of this section, include workpapers and...

  18. Promotive Factors and Psychosocial Adjustment among Urban Youth

    ERIC Educational Resources Information Center

    O'Neal, LaToya J.; Cotten, Shelia R.

    2016-01-01

    Background: Urban youth are often exposed to compounded risk factors which make them more vulnerable to negative outcomes. Research examining promotive factors which may reduce vulnerabilities to poor psychosocial adjustment among this population is limited. Objective: The current study addresses this limitation by examining the impact of…

  19. Troubleshooting Costs

    NASA Astrophysics Data System (ADS)

    Kornacki, Jeffrey L.

    Seventy-six million cases of foodborne disease occur each year in the United States alone. Medical and lost productivity costs of the most common pathogens are estimated to be 5.6-9.4 billion. Product recalls, whether from foodborne illness or spoilage, result in added costs to manufacturers in a variety of ways. These may include expenses associated with lawsuits from real or allegedly stricken individuals and lawsuits from shorted customers. Other costs include those associated with efforts involved in finding the source of the contamination and eliminating it and include time when lines are shut down and therefore non-productive, additional non-routine testing, consultant fees, time and personnel required to overhaul the entire food safety system, lost market share to competitors, and the cost associated with redesign of the factory and redesign or acquisition of more hygienic equipment. The cost associated with an effective quality assurance plan is well worth the effort to prevent the situations described.

  20. Adjustable Induction-Heating Coil

    NASA Technical Reports Server (NTRS)

    Ellis, Rod; Bartolotta, Paul

    1990-01-01

    Improved design for induction-heating work coil facilitates optimization of heating in different metal specimens. Three segments adjusted independently to obtain desired distribution of temperature. Reduces time needed to achieve required temperature profiles.

  1. Costs and Cost-Effectiveness of Training Traditional Birth Attendants to Reduce Neonatal Mortality in the Lufwanyama Neonatal Survival Study (LUNESP)

    PubMed Central

    Sabin, Lora L.; Knapp, Anna B.; MacLeod, William B.; Phiri-Mazala, Grace; Kasimba, Joshua; Hamer, Davidson H.; Gill, Christopher J.

    2012-01-01

    Background The Lufwanyama Neonatal Survival Project (“LUNESP”) was a cluster randomized, controlled trial that showed that training traditional birth attendants (TBAs) to perform interventions targeting birth asphyxia, hypothermia, and neonatal sepsis reduced all-cause neonatal mortality by 45%. This companion analysis was undertaken to analyze intervention costs and cost-effectiveness, and factors that might improve cost-effectiveness. Methods and Findings We calculated LUNESP's financial and economic costs and the economic cost of implementation for a forecasted ten-year program (2011–2020). In each case, we calculated the incremental cost per death avoided and disability-adjusted life years (DALYs) averted in real 2011 US dollars. The forecasted 10-year program analysis included a base case as well as ‘conservative’ and ‘optimistic’ scenarios. Uncertainty was characterized using one-way sensitivity analyses and a multivariate probabilistic sensitivity analysis. The estimated financial and economic costs of LUNESP were $118,574 and $127,756, respectively, or $49,469 and $53,550 per year. Fixed costs accounted for nearly 90% of total costs. For the 10-year program, discounted total and annual program costs were $256,455 and $26,834 respectively; for the base case, optimistic, and conservative scenarios, the estimated cost per death avoided was $1,866, $591, and $3,024, and cost per DALY averted was $74, $24, and $120, respectively. Outcomes were robust to variations in local costs, but sensitive to variations in intervention effect size, number of births attended by TBAs, and the extent of foreign consultants' participation. Conclusions Based on established guidelines, the strategy of using trained TBAs to reduce neonatal mortality was ‘highly cost effective’. We strongly recommend consideration of this approach for other remote rural populations with limited access to health care. PMID:22545117

  2. Price adjustment in the hospital sector: how should the NHS discriminate between providers. A comment on Miraldo, Siciliani and Street.

    PubMed

    Mougeot, Michel; Naegelen, Florence

    2012-01-01

    Miraldo et al. (2011) have analyzed the price adjustment policy of a payer implementing a Prospective Payment System in the hospital sector in the presence of exogenous cost differences when no lump-sum transfers are allowed. They focus on deriving conditions for the price adjustment being positive. In this paper, using a result of Miraldo et al., we emphasize whether the price adjustment is larger or smaller than the marginal cost. We show how the discrimination operates against either the low-cost or the high-cost hospitals according to the value of the elasticity of the additional marginal cost with respect to the quantity of services.

  3. Adjustment in mothers of children with Asperger syndrome: an application of the double ABCX model of family adjustment.

    PubMed

    Pakenham, Kenneth I; Samios, Christina; Sofronoff, Kate

    2005-05-01

    The present study examined the applicability of the double ABCX model of family adjustment in explaining maternal adjustment to caring for a child diagnosed with Asperger syndrome. Forty-seven mothers completed questionnaires at a university clinic while their children were participating in an anxiety intervention. The children were aged between 10 and 12 years. Results of correlations showed that each of the model components was related to one or more domains of maternal adjustment in the direction predicted, with the exception of problem-focused coping. Hierarchical regression analyses demonstrated that, after controlling for the effects of relevant demographics, stressor severity, pile-up of demands and coping were related to adjustment. Findings indicate the utility of the double ABCX model in guiding research into parental adjustment when caring for a child with Asperger syndrome. Limitations of the study and clinical implications are discussed.

  4. Department of Energy Environmental Management cost infrastructure development program: Cost analysis requirements

    SciTech Connect

    Custer, W.R. Jr.; Messick, C.D.

    1996-03-31

    This report was prepared to support development of the Department of Energy Environmental Management cost infrastructure -- a new capability to independently estimate and analyze costs. Currently, the cost data are reported according to a structure that blends level of effort tasks with product and process oriented tasks. Also. the budgetary inputs are developed from prior year funding authorizations and from contractor-developed parametric estimates that have been adjusted to planned funding levels or appropriations. Consequently, it is difficult for headquarters and field-level activities to use actual cost data and technical requirements to independently assess the costs generated and identify trends, potential cost savings from process improvements, and cost reduction strategies.

  5. RBA: Reduced Bundle Adjustment for oblique aerial photogrammetry

    NASA Astrophysics Data System (ADS)

    Sun, Yanbiao; Sun, Huabo; Yan, Lei; Fan, Shiyue; Chen, Rui

    2016-11-01

    This study proposes an efficient Bundle Adjustment (BA) model for oblique aerial photogrammetry to reduce the number of unknown parameters and the dimensions of a non-linear optimization problem. Instead of serving as independent exterior orientations, oblique camera poses are parameterized with nadir camera poses and constant relative poses between oblique and nadir cameras. New observation functions are created with image points as a function of the nadir pose and the relative pose parameters. With these observation functions, the problem of BA is defined as finding optimal unknown parameters by minimizing the total difference between estimated and observed image points. A Gauss-Newton optimization method is utilized to provide a solution for this least-square problem with a reduced normal equation, which plays a very critical role in the convergence and efficiency of BA. Compared with traditional BA methods, the number of unknown parameters and the dimension of the normal equations decrease, this approach dramatically reduces the computational complexity and memory cost especially for large-scale scenarios with a number of oblique images. Four synthetic datasets and a real dataset were used to check the validation and the accuracy of the proposed method. The accuracy of the proposed method is very close to that of the traditional BA method, but the efficiency can be significantly improved by the proposed method. For very large-scale scenarios, the proposed method can still address the limitation of memory and orientate all images captured by an oblique aerial multi-camera system.

  6. Focus adjustment effects on visual acuity and oculomotor balance with aviator night vision displays.

    PubMed

    Kotulak, J C; Morse, S E

    1994-04-01

    Sixteen U.S. Army aviators, who were given training on focus adjustment technique with aviator night vision goggles (NVG), showed an improvement in visual acuity with focus adjustment compared to a fixed infinity focus control. The long-term effect of focus adjustment on vision was not measured; however, adjustment accuracy was found to be generally within acceptable limits based on computer modeling and available physiologic data. Fixed focus eyepieces that are set to a low minus power may partially compensate for instrument myopia, but they may not optimize visual acuity to the extent that adjustable focus eyepieces do. Eyepiece adjustment proficiency with present night vision devices can be improved through training that emphasizes focusing to the least possible minus dioptric power. Future night vision displays can minimize focus misadjustment by providing a tactile zero marking, a limited dioptric adjustment range, and a focusing knob capable of finer adjustment than is available with current NVG's.

  7. Cost Effective Prototyping

    NASA Technical Reports Server (NTRS)

    Wickman, Jerry L.; Kundu, Nikhil K.

    1996-01-01

    This laboratory exercise seeks to develop a cost effective prototype development. The exercise has the potential of linking part design, CAD, mold development, quality control, metrology, mold flow, materials testing, fixture design, automation, limited parts production and other issues as related to plastics manufacturing.

  8. Adjusting to Chronic Health Conditions.

    PubMed

    Helgeson, Vicki S; Zajdel, Melissa

    2017-01-03

    Research on adjustment to chronic disease is critical in today's world, in which people are living longer lives, but lives are increasingly likely to be characterized by one or more chronic illnesses. Chronic illnesses may deteriorate, enter remission, or fluctuate, but their defining characteristic is that they persist. In this review, we first examine the effects of chronic disease on one's sense of self. Then we review categories of factors that influence how one adjusts to chronic illness, with particular emphasis on the impact of these factors on functional status and psychosocial adjustment. We begin with contextual factors, including demographic variables such as sex and race, as well as illness dimensions such as stigma and illness identity. We then examine a set of dispositional factors that influence chronic illness adjustment, organizing these into resilience and vulnerability factors. Resilience factors include cognitive adaptation indicators, personality variables, and benefit-finding. Vulnerability factors include a pessimistic attributional style, negative gender-related traits, and rumination. We then turn to social environmental variables, including both supportive and unsupportive interactions. Finally, we review chronic illness adjustment within the context of dyadic coping. We conclude by examining potential interactions among these classes of variables and outlining a set of directions for future research.

  9. Cost analysis of ground-water supplies in the North Atlantic region, 1970

    USGS Publications Warehouse

    Cederstrom, Dagfin John

    1973-01-01

    The cost of municipal and industrial ground water (or, more specifically, large supplies of ground water) at the wellhead in the North Atlantic Region in 1970 generally ranged from 1.5 to 5 cents per thousand gallons. Water from crystalline rocks and shale is relatively expensive. Water from sandstone is less so. Costs of water from sands and gravels in glaciated areas and from Coastal Plain sediments range from moderate to very low. In carbonate rocks costs range from low to fairly high. The cost of ground water at the wellhead is low in areas of productive aquifers, but owing to the cost of connecting pipe, costs increase significantly in multiple-well fields. In the North Atlantic Region, development of small to moderate supplies of ground water may offer favorable cost alternatives to planners, but large supplies of ground water for delivery to one point cannot generally be developed inexpensively. Well fields in the less productive aquifers may be limited by costs to 1 or 2 million gallons a day, but in the more favorable aquifers development of several tens of millions of gallons a day may be practicable and inexpensive. Cost evaluations presented cannot be applied to any one specific well or specific site because yields of wells in any one place will depend on the local geologic and hydrologic conditions; however, with such cost adjustments as may be necessary, the methodology presented should have wide applicability. Data given show the cost of water at the wellhead based on the average yield of several wells. The cost of water delivered by a well field includes costs of connecting pipe and of wells that have the yields and spacings specified. Cost of transport of water from the well field to point of consumption and possible cost of treatment are not evaluated. In the methodology employed, costs of drilling and testing, pumping equipment, engineering for the well field, amortization at 5% percent interest, maintenance, and cost of power are considered. The

  10. MCCB warm adjustment testing concept

    NASA Astrophysics Data System (ADS)

    Erdei, Z.; Horgos, M.; Grib, A.; Preradović, D. M.; Rodic, V.

    2016-08-01

    This paper presents an experimental investigation in to operating of thermal protection device behavior from an MCCB (Molded Case Circuit Breaker). One of the main functions of the circuit breaker is to assure protection for the circuits where mounted in for possible overloads of the circuit. The tripping mechanism for the overload protection is based on a bimetal movement during a specific time frame. This movement needs to be controlled and as a solution to control this movement we choose the warm adjustment concept. This concept is meant to improve process capability control and final output. The warm adjustment device design will create a unique adjustment of the bimetal position for each individual breaker, determined when the testing current will flow thru a phase which needs to trip in a certain amount of time. This time is predetermined due to scientific calculation for all standard types of amperages and complies with the IEC 60497 standard requirements.

  11. Continuously adjustable Pulfrich spectacles for mobile devices

    NASA Astrophysics Data System (ADS)

    Jacobs, Ken; Karpf, Ron

    2012-02-01

    Mobile devices present a challenging platform for 3D video because of inherent device limitations. Continuously Adjustable Pulfrich Spectacles for Mobile Devices (CAPS-MD) is a new implementation of the Pulfrich 3D stereoscopic effect. For every scene that contains lateral motion in a 2D movie, CAPS-MD provides realistic 3D. Since it requires minimal additional processing, it is appropriate for mobile devices. 3D movies utilizing the Pulfrich stereoscopic effect have been made for 80 years using passive viewing spectacles. CAPS-MD use active viewing spectacles to overcome the limitations of passive spectacles. 3D movies normally employ the asymmetry of dual images to produce stereopsis. CAPS-MD works on the principle of illumination asymmetry, and only needs to control the differential lens optical densities. CAPS-MD is fabricated from optoelectronic materials that electronically control the lens optical densities. The eye's retinal triggering is used by CAPS-MD to determine the differential lens optical densities. Motion estimation calculations from the digital image processing used to display 2D video on mobile devices are reused to calculate realtime lens adjustments so CAPS-MD always conform to the optical density that optimizes the Pulfrich stereoscopic effect. Only negligible additional processing is necessary for CAPS-MD to show 3D for every scene that contains lateral motion in any 2D movie.

  12. 7 CFR 701.23 - Eligible costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... as follows: (1) Costs for use of personal equipment shall be limited to those incurred beyond the normal operation of the eligible land. (2) Costs for personal labor shall be limited to personal labor not normally required in the operation of the eligible land. (3) Costs for the use of...

  13. The social costs to the US of monopolization of the world oil market, 1972--1991

    SciTech Connect

    Greene, D.L.; Leiby, P.N.

    1993-03-01

    The partial monopolization of the world oil market by the OPEC cartel has produced significant economic costs to the economies of the world. This paper reports estimates of the costs of monopolization of oil to the US over the period 1972--1991. Two fundamental assumptions of the analysis are, (1) that OPEC has acted as a monopoly, albeit with limited control, knowledge, and ability to act and, (2) that the US and other consuming nations could, through collective (social) action affect the cartel's ability to act as a monopoly. We measure total costs by comparing actual costs for the 1972--1991 period to a hypothetical more competitive'' world oil market scenario. By measuring past costs we avoid the enormous uncertainties about the future course of the world oil market and leave to the reader's judgment the issue of how much the future will be like the past. We note that total cost numbers cannot be used to determine the value of reducing US oil use by one barrel. They are useful for describing the overall size of the petroleum problem and are one important factor in deciding how much effort should be devoted to solving it. Monopoly pricing of oil transfers wealth from US oil consumers to foreign oil producers and, by increasing theeconomic scarcity of oil, reduces the economy's potential to produce. The actions of the OPEC cartel have also produced oil price shocks, both upward and downward, that generate additional costs because of the economy's inherent inability to adjust quickly to a large change in energy prices. Estimated total costs to the United States from these three sources for the 1972--1991 period are put at $4.1 trillion in 1990$($1.2 T wealth transfer, $0.8 T macroeconomic adjustment costs, $2.1 T potential GNP losses). The cost of the US's primary oil supply contingency program is small ($10 B) by comparison.

  14. Nurse Family Partnership: Comparing Costs per Family in Randomized Trials Versus Scale-Up.

    PubMed

    Miller, Ted R; Hendrie, Delia

    2015-12-01

    The literature that addresses cost differences between randomized trials and full-scale replications is quite sparse. This paper examines how costs differed among three randomized trials and six statewide scale-ups of nurse family partnership (NFP) intensive home visitation to low income first-time mothers. A literature review provided data on pertinent trials. At our request, six well-established programs reported their total expenditures. We adjusted the costs to national prices based on mean hourly wages for registered nurses and then inflated them to 2010 dollars. A centralized data system provided utilization. Replications had fewer home visits per family than trials (25 vs. 31, p = .05), lower costs per client ($8860 vs. $12,398, p = .01), and lower costs per visit ($354 vs. $400, p = .30). Sample size limited the significance of these differences. In this type of labor intensive program, costs probably were lower in scale-up than in randomized trials. Key cost drivers were attrition and the stable caseload size possible in an ongoing program. Our estimates reveal a wide variation in cost per visit across six state programs, which suggests that those planning replications should not expect a simple rule to guide cost estimations for scale-ups. Nevertheless, NFP replications probably achieved some economies of scale.

  15. Nurse Family Partnership: Comparing Costs per Family in Randomized Trials versus Scale-up

    PubMed Central

    Miller, Ted R.; Hendrie, Delia

    2015-01-01

    The literature that addresses cost differences between randomized trials and full-scale replications is quite sparse. This paper examines how costs differed among three randomized trials and six statewide scale-ups of Nurse Family Partnership (NFP) intensive home visitation to low income first-time mothers. A literature review provided data on pertinent trials. At our request, six well-established programs reported their total expenditures. We adjusted the costs to national prices based on mean hourly wages for registered nurses and then inflated them to 2010 dollars. A centralized data system provided utilization. Replications had fewer home visits per family than trials (25 vs. 31, p = .05), lower costs per client ($8,860 vs. $12,398, p = .01), and lower costs per visit ($354 vs. $400, p = .30). Sample size limited the significance of these differences. In this type of labor intensive program, costs probably were lower in scale-up than in randomized trials. Key cost drivers were attrition and the stable caseload size possible in an ongoing program. Our estimates reveal a wide variation in cost per visit across six state programs, which suggests that those planning replications should not expect a simple rule to guide cost estimations for scale-ups. Nevertheless, NFP replications probably achieved some economies of scale. PMID:26507844

  16. Cost-effectiveness of interventions to control Campylobacter in the New Zealand poultry meat food supply.

    PubMed

    Lake, Robin J; Horn, Beverley J; Dunn, Alex H; Parris, Ruth; Green, F Terri; McNickle, Don C

    2013-07-01

    An analysis of the cost-effectiveness of interventions to control Campylobacter in the New Zealand poultry supply examined a series of interventions. Effectiveness was evaluated in terms of reduced health burden measured by disability-adjusted life years (DALYs). Costs of implementation were estimated from the value of cost elements, determined by discussions with industry. Benefits were estimated by changing the inputs to a poultry food chain quantitative risk model. Proportional reductions in the number of predicted Campylobacter infections were converted into reductions in the burden of disease measured in DALYs. Cost-effectiveness ratios were calculated for each intervention, as cost per DALY reduction and the ratios compared. The results suggest that the most cost-effective interventions (lowest ratios) are at the primary processing stage. Potential phage-based controls in broiler houses were also highly cost-effective. This study is limited by the ability to quantify costs of implementation and assumptions required to estimate health benefits, but it supports the implementation of interventions at the primary processing stage as providing the greatest quantum of benefit and lowest cost-effectiveness ratios.

  17. 45 CFR 92.22 - Allowable costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Allowable costs. 92.22 Section 92.22 Public... Financial Administration § 92.22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors,...

  18. 29 CFR 1470.22 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Allowable costs. 1470.22 Section 1470.22 Labor Regulations... Financial Administration § 1470.22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors,...

  19. 45 CFR 602.22 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Allowable costs. 602.22 Section 602.22 Public... Requirements § 602.22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type contractors, including allowable...

  20. 45 CFR 2541.220 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Allowable costs. 2541.220 Section 2541.220 Public... Post-Award Requirements § 2541.220 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for— (1) The allowable costs of the grantees, subgrantees and cost-type...

  1. 45 CFR 96.88 - Administrative costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Administrative costs. 96.88 Section 96.88 Public... Assistance Program § 96.88 Administrative costs. (a) Costs of planning and administration. Any expenditure... be included in determining administrative costs subject to the statutory limitation on...

  2. 38 CFR 43.22 - Allowable costs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Allowable costs. 43.22... Requirements Financial Administration § 43.22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used only for: (1) The allowable costs of the grantees, subgrantees and cost-type...

  3. 38 CFR 17.274 - Cost sharing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the beneficiary cost share. (b) In addition to the beneficiary cost share, an annual (calendar year... illness or injury, a calendar year cost limit or “catastrophic cap” has been placed on the beneficiary... cap computation. After a family has paid the maximum cost-share and deductible amounts for a...

  4. 38 CFR 17.274 - Cost sharing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the beneficiary cost share. (b) In addition to the beneficiary cost share, an annual (calendar year... illness or injury, a calendar year cost limit or “catastrophic cap” has been placed on the beneficiary... cap computation. After a family has paid the maximum cost-share and deductible amounts for a...

  5. Adjustable Optical-Fiber Attenuator

    NASA Technical Reports Server (NTRS)

    Buzzetti, Mike F.

    1994-01-01

    Adjustable fiber-optic attenuator utilizes bending loss to reduce strength of light transmitted along it. Attenuator functions without introducing measurable back-reflection or insertion loss. Relatively insensitive to vibration and changes in temperature. Potential applications include cable television, telephone networks, other signal-distribution networks, and laboratory instrumentation.

  6. Dyadic Adjustment: An Ecosystemic Examination.

    ERIC Educational Resources Information Center

    Wilson, Stephan M.; Larson, Jeffry H.; McCulloch, B. Jan; Stone, Katherine L.

    1997-01-01

    Examines the relationship of background, individual, and family influences on dyadic adjustment, using an ecological perspective. Data from 102 married couples were used. Age at marriage for husbands, emotional health for wives, and number of marriage and family problems as well as family life satisfaction for both were related to dyadic…

  7. Problems of Adjustment to School.

    ERIC Educational Resources Information Center

    Bartolini, Leandro A.

    This paper, one of several written for a comprehensive policy study of early childhood education in Illinois, examines and summarizes the literature on the problems of young children in adjusting to starting school full-time and describes the nature and extent of their difficulties in relation to statewide educational policy. The review of studies…

  8. Economic Pressures and Family Adjustment.

    ERIC Educational Resources Information Center

    Haccoun, Dorothy Markiewicz; Ledingham, Jane E.

    The relationships between economic stress on the family and child and parental adjustment were examined for a sample of 199 girls and boys in grades one, four, and seven. These associations were examined separately for families in which both parents were present and in which mothers only were at home. Economic stress was associated with boys'…

  9. Costing blood products and services.

    PubMed

    Wallace, E L

    1991-05-01

    At present, blood centers and transfusion services have limited alternatives for offsetting the ever-rising costs of health care inputs. In the face of current revenue constraints, cost reduction or cost containment through efficiency improvements or service reduction is the principal available means. Such methods ought to be pursued vigorously by blood bankers with the aid of well-designed costing and other physical measurements systems. Experience indicates, however, that blood bankers, in their attempts to reduce or contain costs, are likely to place undue reliance on cost accounting systems as the means of capturing sought-for benefits. Management must learn enough about methods of costing to judge directly the uses and limitations of the information produced. Such understanding begins with recognition that all costs and cost comparisons should be specific to the purpose for which they are developed. No costing procedure is capable of producing measures generally applicable to all management decisions. A measure relevant to a planning decision is unlikely to be appropriate for performance evaluation. Useful comparisons among sets of organizations of costs, or of measures of physical inputs and outputs, require assurance that the methods of measurement employed are the same and that the sets of organizations from which the measures are drawn are reasonably comparable.

  10. 46 CFR 309.6 - Adjustments for condition, equipment, and other considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Adjustments for condition, equipment, and other... OPERATIONS VALUES FOR WAR RISK INSURANCE § 309.6 Adjustments for condition, equipment, and other... stated valuation. (b) Special equipment. If the depreciated reproduction cost less construction...

  11. Cost-effectiveness of a package of interventions for expedited antiretroviral therapy initiation during pregnancy in Cape Town, South Africa.

    PubMed

    Zulliger, Rose; Black, Samantha; Holtgrave, David R; Ciaranello, Andrea L; Bekker, Linda-Gail; Myer, Landon

    2014-04-01

    Initiating antiretroviral therapy (ART) early in pregnancy is an important component of effective interventions to prevent the mother-to-child transmission of HIV (PMTCT). The rapid initiation of ART in pregnancy(RAP) program was a package of interventions to expedite ART initiation in pregnant women in Cape Town, South Africa. Retrospective cost-effectiveness, sensitivity and threshold analyses were conducted of the RAP program to determine the cost-utility thresholds for rapid initiation of ART in pregnancy. Costs were drawn from a detailed micro-costing of the program. The overall programmatic cost was US$880 per woman and the base case cost-effectiveness ratio was US$1,160 per quality-adjusted lifeyear (QALY) saved. In threshold analyses, the RAP program remained cost-effective if mother-to-child transmission was reduced by C0.33 %; if C1.76 QALY were saved with each averted perinatal infection; or if RAP-related costs were under US$4,020 per woman. The package of rapid initiation services was very cost-effective, as compared to standard services in this setting. Threshold analyses demonstrated that the intervention required minimal reductions in perinatal infections in order to be cost-effective. Interventions for the rapid initiation of ART in pregnancy hold considerable potential as a cost-effective use of limited resources for PMTCT in sub-Saharan Africa.

  12. Cost Control

    ERIC Educational Resources Information Center

    Foreman, Phillip

    2009-01-01

    Education administrators involved in construction initiatives unanimously agree that when it comes to change orders, less is more. Change orders have a negative rippling effect of driving up building costs and producing expensive project delays that often interfere with school operations and schedules. Some change orders are initiated by schools…

  13. Cost-utility analysis of stenting versus endarterectomy in the International Carotid Stenting Study

    PubMed Central

    Morris, Stephen; Patel, Nishma V; Dobson, Joanna; Featherstone, Roland L; Richards, Toby; Luengo-Fernandez, Ramon; Rothwell, Peter M; Brown, Martin M

    2017-01-01

    Background The International Carotid Stenting Study (ICSS) was a multicentre randomised trial in which patients with symptomatic carotid artery stenosis were randomly allocated to treatment by carotid stenting or endarterectomy. Economic evidence comparing these treatments is limited and inconsistent. Aims We compared the cost-effectiveness of stenting versus endarterectomy using ICSS data. Methods We performed a cost-utility analysis estimating mean costs and quality-adjusted life years (QALYs) per patient for both treatments over a five-year time horizon based on resource use data and utility values collected in the trial. Costs of managing stroke events were estimated using individual patient data from a UK population-based study (Oxford Vascular Study). Results Mean costs per patient (95% CI) were US$10 477 ($9669 to $11 285) in the stenting group (N=853) and $9669 ($8835 to $10 504) in the endarterectomy group (N=857).There were no differences in mean QALYs per patient (3.247 (3.160 to 3.333) and 3.228 (3.150 to 3.306), respectively). There were no differences in adjusted costs between groups (mean incremental costs for stenting versus endarterectomy $736 (95% CI -$353 to $1826)) or adjusted outcomes (mean QALYs gained -0.010 (95% CI -0.117 to 0.097)). The incremental net monetary benefit for stenting versus endarterectomy was not significantly different from zero at the maximum willingness to pay for a QALY commonly used in the UK. Sensitivity analyses showed little uncertainty in these findings. Conclusions Economic considerations should not affect whether patients with symptomatic carotid stenosis undergo stenting or endarterectomy. PMID:26880056

  14. Current limiters

    SciTech Connect

    Loescher, D.H.; Noren, K.

    1996-09-01

    The current that flows between the electrical test equipment and the nuclear explosive must be limited to safe levels during electrical tests conducted on nuclear explosives at the DOE Pantex facility. The safest way to limit the current is to use batteries that can provide only acceptably low current into a short circuit; unfortunately this is not always possible. When it is not possible, current limiters, along with other design features, are used to limit the current. Three types of current limiters, the fuse blower, the resistor limiter, and the MOSFET-pass-transistor limiters, are used extensively in Pantex test equipment. Detailed failure mode and effects analyses were conducted on these limiters. Two other types of limiters were also analyzed. It was found that there is no best type of limiter that should be used in all applications. The fuse blower has advantages when many circuits must be monitored, a low insertion voltage drop is important, and size and weight must be kept low. However, this limiter has many failure modes that can lead to the loss of over current protection. The resistor limiter is simple and inexpensive, but is normally usable only on circuits for which the nominal current is less than a few tens of milliamperes. The MOSFET limiter can be used on high current circuits, but it has a number of single point failure modes that can lead to a loss of protective action. Because bad component placement or poor wire routing can defeat any limiter, placement and routing must be designed carefully and documented thoroughly.

  15. Force Limit System

    NASA Technical Reports Server (NTRS)

    Pawlik, Ralph; Krause, David; Bremenour, Frank

    2011-01-01

    The Force Limit System (FLS) was developed to protect test specimens from inadvertent overload. The load limit value is fully adjustable by the operator and works independently of the test system control as a mechanical (non-electrical) device. When a test specimen is loaded via an electromechanical or hydraulic test system, a chance of an overload condition exists. An overload applied to a specimen could result in irreparable damage to the specimen and/or fixturing. The FLS restricts the maximum load that an actuator can apply to a test specimen. When testing limited-run test articles or using very expensive fixtures, the use of such a device is highly recommended. Test setups typically use electronic peak protection, which can be the source of overload due to malfunctioning components or the inability to react quickly enough to load spikes. The FLS works independently of the electronic overload protection.

  16. Cost-utility analysis.

    PubMed Central

    Robinson, R

    1993-01-01

    Decisions have to be made about allocating health resources. Currently the best economic evaluation method for doing this is cost-utility analysis. This compares the costs of different procedures with their outcomes measured in "utility based" units--that is, units that relate to a person's level of wellbeing. The most commonly used unit is the quality adjusted life year (QALY). QALYs are calculated by estimating the total life years gained from a procedure and weighting each year to reflect the quality of life in that year. To compare outcomes of different programmes the Rosser index is one measure that is widely used to assign quality of life scores to patients. Combined with a measure of life years gained from a procedure, this enables QALYs to be calculated and procedures ranked according to cost per QALY gained. In this article Ray Robinson explains the measures used and discusses how QALY league tables can be used to guide decisions on resource allocation. Images p862-a PMID:8401133

  17. Analysis, design, and control of a novel optically commutated adjustable-speed motor

    NASA Astrophysics Data System (ADS)

    Newman, Wyatt S.; Risch, Ivan; Zhang, Yuandao; Garverick, Steven; Inerfield, Michael

    1998-12-01

    This paper describes the analysis, design and control of a novel, single-phase motor with a unique behavior resulting from the use of rotating power electronics mounted to the motor armature. Coils on the armature are selectively shorted by power MOSFET's which rotate with the armature, and torque is produced by interaction between currents induced in the shorted coils and the magnetic field produced by a stationary field coil. Control is limited to the timing of which armature coils are to be shorted as a function of armature speed and angle, it is possible to modulate torque production and obtain torque or speed control using only single-phase ac power and without the use of brushes or permanent magnets. An electro-mechanical model for this type of motor is presented and validated with respect to experimentation. The results show promise for achieving low- cost, adjustable-speed drives using this novel method of rotating electronics, optical communications, and computed commutation.

  18. Cost-effectiveness and clinical outcomes of double versus single cord blood transplantation in adults with acute leukemia in France.

    PubMed

    Labopin, Myriam; Ruggeri, Annalisa; Gorin, Norbert Claude; Gluckman, Eliane; Blaise, Didier; Mannone, Lionel; Milpied, Noel; Yakoub-Agha, Ibrahim; Deconinck, Eric; Michallet, Mauricette; Fegueux, Nathalie; Socié, Gerard; Nguyen, Stephanie; Cahn, Jean Yves; de Revel, Thierry; Garnier, Federico; Faucher, Catherine; Taright, Namik; Kenzey, Chantal; Volt, Fernanda; Bertrand, Dominique; Mohty, Mohamad; Rocha, Vanderson

    2014-03-01

    Double cord blood transplantation extends the use of cord blood to adults for whom a single unit is not available, but the procedure is limited by its cost. To evaluate outcomes and cost-effectiveness of double compared to single cord blood transplantation, we analyzed 134 transplants in adults with acute leukemia in first remission. Transplants were performed in France with reduced intensity or myeloablative conditioning regimens. Costs were estimated from donor search to 1 year after transplantation. A Markov decision analysis model was used to calculate quality-adjusted life-years and cost-effectiveness ratio within 4 years. The overall survival at 2 years after single and double cord blood transplants was 42% versus 62%, respectively (P=0.03), while the leukemia-free-survival was 33% versus 53%, respectively (P=0.03). The relapse rate was 21% after double transplants and 42% after a single transplant (P=0.006). No difference was observed for non-relapse mortality or chronic graft-versus-host-disease. The estimated costs up to 1 year after reduced intensity conditioning for single and double cord blood transplantation were € 165,253 and €191,827, respectively. The corresponding costs after myeloablative conditioning were € 192,566 and € 213,050, respectively. Compared to single transplants, double cord blood transplantation was associated with supplementary costs of € 21,302 and € 32,420 up to 4 years, but with increases in quality-adjusted life-years of 0.616 and 0.484, respectively, and incremental cost-effectiveness ratios of € 34,581 and €66,983 in the myeloablative and reduced intensity conditioning settings, respectively. Our results showed that for adults with acute leukemia in first complete remission in France, double cord transplantation is more cost-effective than single cord blood transplantation, with better outcomes, including quality-adjusted life-years.

  19. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount of each civil money penalty within the OCC's jurisdiction is adjusted in accordance with the...

  20. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...