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Sample records for adjustment scale pas

  1. Predicting Prison Adjustment with MMPI Correctional Scales.

    ERIC Educational Resources Information Center

    Megargee, Edwin I.; Carbonell, Joyce L.

    1985-01-01

    Investigated the degree to which eight Minnesota Multiphasic Personality Inventory scales, specifically derived to assess correctional criteria, related to six criteria of subsequent adjustment in prison. Although some statistically significant correlations with the criteria were obtained, their magnitude was quite low, indicating the scales had…

  2. Adjustments to the ICVGT scale of INRIM

    NASA Astrophysics Data System (ADS)

    Steur, P. P. M.; Giraudi, D.

    2013-09-01

    At the 8th Temperature Symposium the results have been presented for the Interpolating Constant Volume Gas thermometer at INRIM (then IMGC), featuring a cryogenic pressure transducer, with an expanded uncertainty of less then 1.5 mK. However, for its fixed points this scale still relied on a NPL calibration as carried by rhodium-iron thermometer 232324. After the clarification, in 2005, by the Consultative Committee on Thermometry (CCT) of the definition of the equilibrium hydrogen (e-H2) triple point this scale was due to be adjusted for the isotopic content in the e-H2 fixed point cell. Only when this thermometer was re-calibrated in 2010 at INRIM at the three fixed points of the ICVGT was this adjustment performed, being the isotopic composition of the hydrogen cell known. With the start of the Neon Project in 2005, it became clear that a second adjustment would soon be needed, once the CCT will have decided on the way to deal with the isotopic composition of neon. The paper presents the experimental data of 2010, discusses the stability of the thermometer, and the size of the correction at the hydrogen point and of the likely correction (and its uncertainty) to be applied to the neon point, the isotopic composition of this cell being known as well.

  3. Adjustments to the ICVGT scale of INRIM

    SciTech Connect

    Steur, P. P. M.; Giraudi, D.

    2013-09-11

    At the 8{sup th} Temperature Symposium the results have been presented for the Interpolating Constant Volume Gas thermometer at INRIM (then IMGC), featuring a cryogenic pressure transducer, with an expanded uncertainty of less then 1.5 mK. However, for its fixed points this scale still relied on a NPL calibration as carried by rhodium-iron thermometer 232324. After the clarification, in 2005, by the Consultative Committee on Thermometry (CCT) of the definition of the equilibrium hydrogen (e-H2) triple point this scale was due to be adjusted for the isotopic content in the e-H2 fixed point cell. Only when this thermometer was re-calibrated in 2010 at INRIM at the three fixed points of the ICVGT was this adjustment performed, being the isotopic composition of the hydrogen cell known. With the start of the Neon Project in 2005, it became clear that a second adjustment would soon be needed, once the CCT will have decided on the way to deal with the isotopic composition of neon. The paper presents the experimental data of 2010, discusses the stability of the thermometer, and the size of the correction at the hydrogen point and of the likely correction (and its uncertainty) to be applied to the neon point, the isotopic composition of this cell being known as well.

  4. Family Adjustment Measure: Scale Construction and Validation

    ERIC Educational Resources Information Center

    Daire, Andrew P.; Dominguez, Vanessa N.; Carlson, Ryan G.; Case-Pease, Jenene

    2014-01-01

    We administered the Family Adjustment Measure to 368 parents of children with special needs to identify positive adjustment. We randomly split the sample to conduct exploratory factor analysis ("n" = 194) and confirmatory factor analysis ("n" = 174). Results indicated four possible subscales and that explain 51% of the variance.

  5. SIDS Family Adjustment Scale: A Method of Assessing Family Adjustment to Sudden Infant Death Syndrome.

    ERIC Educational Resources Information Center

    May, Harold J.; Breme, Frederick J.

    1982-01-01

    Discusses Sudden Infant Death Syndrome (SIDS) and the family's resultant grief process. Explores SIDS as a family crisis, and by identifying the psychological factors or tasks pertinent to family adjustment, proposes a SIDS Family Adjustment Scale which assists in recognizing adaptive and maladaptive grief responses. (Author)

  6. Scale-adjusted volatility and the Dow Jones index

    NASA Astrophysics Data System (ADS)

    Ellis, Craig; Hudson, Christopher

    2007-05-01

    This paper extends research by Batten and Ellis [Econ. Lett. 72 (2001) 291] to propose a simple model of scale-adjusted volatility which measures the extent to which the Gaussian scaling law mis-estimates long-horizon volatility. Applied to the Dow Jones industrial average, the results of our model show a dramatic improvement over the Gaussian scaling law in predicting long-horizon volatility. Our model provides a general framework for estimating scaled volatility that may be also applied to other fields of study where the Hurst exponent is commonly used.

  7. Factorial Invariance of the Dyadic Adjustment Scale across Gender

    ERIC Educational Resources Information Center

    South, Susan C.; Krueger, Robert F.; Iacono, William G.

    2009-01-01

    The Dyadic Adjustment Scale (DAS; G. B. Spanier, 1976) is the most widely used inventory of relationship satisfaction in the social sciences, yet the question of whether it is measuring the same concept in men and women has never been addressed. In the current study, the authors examined the factor structure of the DAS in a sample of 900 currently…

  8. Factorial Invariance of the Dyadic Adjustment Scale across Gender

    PubMed Central

    South, Susan C.; Krueger, Robert F.; Iacono, William G.

    2009-01-01

    The Dyadic Adjustment Scale (Spanier, 1976) is the most widely used inventory of relationship satisfaction in the social sciences, yet the question of whether it is measuring the same concept in men and women has never been addressed. The current study examined the factor structure of the DAS in a sample of 900 currently married couples who participated in the Minnesota Twin Family Study. Confirmatory factory analysis was applied to a second-order factor solution with Spanier’s four factors (Consensus, Satisfaction, Cohesion, Affectional Expression) loading on one, higher-order factor (Adjustment) to test for measurement invariance across gender. The second-order solution was relatively invariant across gender, even when taking into account the non-independent nature of the data. This suggests that the best conceptualization of the DAS is one of a gender-invariant measure of marital adjustment with four distinct subfactors, and that differences between men and women on any of these constructs can be interpreted by both clinicians and researchers as true mean differences rather than measurement bias. PMID:19947795

  9. Development and Preliminary Validation of Diabetes Adjustment Assessment Scale (DAAS): a New Measure of Adjustment with Type 2 Diabetes

    PubMed Central

    Ebrahimi, Hossein; Karimi Moonaghi, Hossein; Asghari Jafarabadi, Mohammad; Namdar Areshtanab, Hossein; Jouybari, Leila

    2016-01-01

    Introduction: Several adjustment scales are available for Diabetes, but, unfortunately most of them focused on the limited dimensions of diabetes and are not specific for type 2 diabetes. The aim of this study was to develop a multidimensional scale for Diabetes type 2 Adjustment Assessment and to test preliminary validity, reliability and clinical utility of the scale for this population. Methods: In this methodological design study, the Diabetes Adjustment Assessment Scale was developed and the psychometric properties of this scale was assessed in patients with Type 2 diabetes. This study included internal consistency, content validity and exploratory factor analysis. Results: 1000 patients with type 2 diabetes completed the 45-item Diabetes Adjustment Scale. After eliminating two item, the 43-item measure demonstrated good internal consistency (Cronbach’s α= 0.75). Factor analysis identified eight factors including; reshape (11 questions), seek to acceptance of illness (7 questions), normal life with the disease (6 questions), initial self-management (2 questions), comparing (4 questions), initial imaging of illness (4 questions), return to resources(3 questions), and advanced self- management (6 questions). Conclusion: Considering that validity and reliability indexes of the scale are reported in an appropriate level, it can be used as a valid and reliable tool in measuring level of adjustment with type2 diabetes. PMID:27354978

  10. How resilient are resilience scales? The Big Five scales outperform resilience scales in predicting adjustment in adolescents.

    PubMed

    Waaktaar, Trine; Torgersen, Svenn

    2010-04-01

    This study's aim was to determine whether resilience scales could predict adjustment over and above that predicted by the five-factor model (FFM). A sample of 1,345 adolescents completed paper-and-pencil scales on FFM personality (Hierarchical Personality Inventory for Children), resilience (Ego-Resiliency Scale [ER89] by Block & Kremen, the Resilience Scale [RS] by Wagnild & Young) and adaptive behaviors (California Healthy Kids Survey, UCLA Loneliness Scale and three measures of school adaptation). The results showed that the FFM scales accounted for the highest proportion of variance in disturbance. For adaptation, the resilience scales contributed as much as the FFM. In no case did the resilience scales outperform the FFM by increasing the explained variance. The results challenge the validity of the resilience concept as an indicator of human adaptation and avoidance of disturbance, although the concept may have heuristic value in combining favorable aspects of a person's personality endowment. PMID:19961558

  11. Detecting Anchoring-and-Adjusting in Survey Scales

    ERIC Educational Resources Information Center

    McIntyre, Joe

    2014-01-01

    Proper survey design is essential to obtain reliable, replicable data from research subjects. One threat to inferences drawn from surveys is anchoring-and-adjusting. Tversky and Kahnemann (1974) observed that participants' responses to questions depended systematically on irrelevant information they received prior to answering. It is important for…

  12. ICAPS: A New Scale of Intercultural Adjustment II.

    ERIC Educational Resources Information Center

    Ratzlaff, Charlotte; LeRoux, Jeffrey; Nishinohara, Hiromi; Vogt, Axel Lee; Kim, Chu; Matsumoto, David

    This paper discusses the development of a questionnaire to measure attitudes and beliefs that predict intercultural adjustment (ICA) as opposed to intercultural communication or acculturation. Piloting of the first version of the measure suggested that 153 items may be valid predictors of ICA; this study attempts to further reduce the number of…

  13. The J-PAS filter system

    NASA Astrophysics Data System (ADS)

    Marin-Franch, Antonio; Taylor, Keith; Cenarro, Javier; Cristobal-Hornillos, David; Moles, Mariano

    2015-08-01

    J-PAS (Javalambre-PAU Astrophysical Survey) is a Spanish-Brazilian collaboration to conduct a narrow-band photometric survey of 8500 square degrees of northern sky using an innovative filter system of 59 filters, 56 relatively narrow-band (FWHM=14.5 nm) filters continuously populating the spectrum between 350 to 1000nm in 10nm steps, plus 3 broad-band filters. This filter system will be able to produce photometric redshifts with a precision of 0.003(1 + z) for Luminous Red Galaxies, allowing J-PAS to measure the radial scale of the Baryonic Acoustic Oscillations. The J-PAS survey will be carried out using JPCam, a 14-CCD mosaic camera using the new e2v 9k-by-9k, 10μm pixel, CCDs mounted on the JST/T250, a dedicated 2.55m wide-field telescope at the Observatorio Astrofísico de Javalambre (OAJ) near Teruel, Spain. The filters will operate in a fast (f/3.6) converging beam. The requirements for average transmissions greater than 85% in the passband, <10-5 blocking from 250 to 1050nm, steep bandpass edges and high image quality impose significant challenges for the production of the J-PAS filters that have demanded the development of new design solutions. This talk presents the J-PAS filter system and describes the most challenging requirements and adopted design strategies. Measurements and tests of the first manufactured filters are also presented.

  14. Scaling and Suppression of Heating in an Adjustable Ion Trap

    NASA Astrophysics Data System (ADS)

    Olmschenk, Steven; Deslauriers, Louis; Stick, Dan; Hensinger, Winfried; Sterk, Jon; Monroe, Christopher

    2006-05-01

    One of the major hurdles in the realization of large entangled states among trapped ions is anomalous heating of trapped ion motion [1]. We implement a novel rf ion trap featuring moveable electrodes that has enabled a controlled investigation of this motional decoherence. First, we characterize heating as a function of electrode proximity, related to the geometry of noisy potentials on the electrode surface. Second, we cool the electrodes via contact with a liquid nitrogen reservoir and observe that the decoherence rate is suppressed by an order of magnitude. The insight gained through these experiments may have relevance to scaling the ion trap quantum information processor. 1. Q. A. Turchette, et. al., Phys. Rev. A 61, 063418 (2000).

  15. Catchment- and reach-scale controls on the distribution and expectation of geomorphic channel adjustment

    NASA Astrophysics Data System (ADS)

    Lisenby, Peyton E.; Fryirs, Kirstie A.

    2016-05-01

    Variability in channel function (behavior) can be assessed by characterizing different forms of adjustment over time. Here, historical channel adjustments in three tributary systems of the Lockyer Valley, Southeast Queensland (SEQ) are analyzed in order to evaluate the range of catchment- and reach-scale controls on channel behavior. Over 300 individual adjustments and 13 forms of adjustment were identified over a ˜130 year time span. We measured the width-to-depth ratio (W:D), mean stream power (ω), and basin area (A) at the location of all observed adjustments. The most common forms of adjustment were avulsions, lateral expansion of the channel, and bend adjustments. The tributary systems behave distinctly different from one another according to statistical comparisons between the W:D, ω, and A data for these forms of adjustment. We find that it is possible to develop process domains or typologies for forms of geomorphic adjustment found in the Lockyer Valley. These domains or typologies provide the foundations for synoptic comparisons between catchments and assessing the expectation of channel adjustment (forecasting), which should be included in process-based river management practice.

  16. Scale-dependent hierarchical adjustments of movement patterns in a long-range foraging seabird.

    PubMed Central

    Fritz, Hervé; Said, Sonia; Weimerskirch, Henri

    2003-01-01

    Foraging animals are expected to adjust their path according to the hierarchical spatial distribution of food resources and environmental factors. Studying such behaviour requires methods that allow for the detection of changes in pathways' characteristics across scales, i.e. a definition of scale boundaries and techniques to continuously monitor the precise movement of the animal over a sufficiently long period. We used a recently developed application of fractals, the changes in fractal dimension within a path and applied it to foraging trips over scales ranging across five orders of magnitude (10 m to 1000 km), using locations of wandering albatrosses (Diomedea exulans) recorded at 1 s intervals with a miniaturized global positioning system. Remarkably, all animals consistently showed the same pattern: the use of three scale-dependent nested domains where they adjust tortuosity to different environmental and behavioural constraints. At a small scale (ca. 100 m) they use a zigzag movement as they continuously adjust for optimal use of wind; at a medium scale (1-10 km), the movement shows changes in tortuosity consistent with food-searching behaviour; and at a large scale (greater than 10 km) the movement corresponds to commuting between patches and is probably influenced by large-scale weather systems. Our results demonstrate the possibility of identifying the hierarchical spatial scales at which long-ranging animals adjust their foraging behaviour, even in featureless environments such as oceans, and hence how to relate their movement patterns to environmental factors using an objective mathematical approach. PMID:12816652

  17. Development and Validation of Social Provision Scale on First Year Undergraduate Psychological Adjustment

    ERIC Educational Resources Information Center

    Oluwatomiwo, Oladunmoye Enoch

    2015-01-01

    This study examined the development and validation of socio provision scale on first year undergraduates adjustment among institution in Ibadan metropolis. The study adopted a descriptive survey design. A sample of 300 participants was randomly selected across institutions in Ibadan. Data were collected using socio provision scale (a =0.76),…

  18. Dysbindin (DTNBP1, 6p22.3) is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS)

    ERIC Educational Resources Information Center

    Gornick, M. C.; Addington, A. M.; Sporn, A.; Gogtay, N.; Greenstein, D.; Lenane, M.; Gochman, P.; Ordonez, A.; Balkissoon, R.; Vakkalanka, R.; Weinberger, D. R.; Rapoport, J. L.; Straub, R. E.

    2005-01-01

    Straub "et al." ("2002") recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid…

  19. Trinidad and Tobago National Standardization of the Adjustment Scales for Children and Adolescents

    ERIC Educational Resources Information Center

    McDermott, Paul A.; Watkins, Marley W.; Rhoad, Anna M.; Chao, Jessica L.; Worrell, Frank C.; Hall, Tracey E.

    2015-01-01

    Given relevant cultural distinctions across nations, it is important to determine the dimensional structure and normative characteristics of psychological assessment devices in each focal population. This article examines the national standardization and validation of the Adjustment Scales for Children and Adolescents (ASCA) with a nationally…

  20. Normative Data on the College Adjustment Scales from a University Counseling Center.

    ERIC Educational Resources Information Center

    Nafziger, Mark A.; Couillard, Gwena C.; Smith, Timothy B.; Wiswell, Denise K.

    1998-01-01

    Normative data on the College Adjustment Scales (CAS) were gathered from university counseling center clients. Counseling center clients differed significantly from two nonclient student comparison groups, especially in reported problems with anxiety, depression, and self-esteem. Undergraduate and graduate students also differed on most CAS…

  1. Evaluation of a New Mean Scaled and Moment Adjusted Test Statistic for SEM

    ERIC Educational Resources Information Center

    Tong, Xiaoxiao; Bentler, Peter M.

    2013-01-01

    Recently a new mean scaled and skewness adjusted test statistic was developed for evaluating structural equation models in small samples and with potentially nonnormal data, but this statistic has received only limited evaluation. The performance of this statistic is compared to normal theory maximum likelihood and 2 well-known robust test…

  2. Adjustment Scales for Children and Adolescents: Factorial Validity in a Canadian Sample

    ERIC Educational Resources Information Center

    Canivez, Gary L.; Beran, Tanya N.

    2009-01-01

    The core syndrome factor structure of the Adjustment Scales for Children and Adolescents (ASCA) was examined with a sample of 375 randomly selected Canadian youths in a large western city. The 6 ASCA core syndrome raw scores produced an identical two-factor solution as observed in samples of American youths. Principal axis exploratory factor…

  3. Adjustment Scales for Children and Adolescents and Native American Indians: Factorial Validity Generalization for Ojibwe Youths

    ERIC Educational Resources Information Center

    Canivez, Gary L.

    2006-01-01

    Replication of the core syndrome factor structure of the "Adjustment Scales for Children and Adolescents" (ASCA; P.A. McDermott, N.C. Marston, & D.H. Stott, 1993) is reported for a sample of 183 Native American Indian (Ojibwe) children and adolescents from North Central Minnesota. The six ASCA core syndromes produced an identical two-factor…

  4. Dimensionality of the Chinese Dyadic Adjustment Scale Based on Confirmatory Factor Analyses

    ERIC Educational Resources Information Center

    Shek, Daniel T. L.; Cheung, C. K.

    2008-01-01

    Based on the responses of 1,501 Chinese married adults to the Chinese version of the Dyadic Adjustment Scale (C-DAS), confirmatory factor analyses showed that four factors were abstracted from the C-DAS (Dyadic Consensus, Dyadic Cohesion, Dyadic Satisfaction and Affectional Expression) and these four primary factors were subsumed under a…

  5. Replication of the Adjustment Scales for Children and Adolescents Core Syndrome Factor Structure

    ERIC Educational Resources Information Center

    Canivez, Gary L.

    2004-01-01

    Independent examination and replication of the core syndrome factor structure of the Adjustment Scales for Children and Adolescents (ASCA; McDermott, Marston, & Stott, 1993) is reported. A sample of 1,020 children were randomly selected from their classroom and rated on the ASCA by their teacher. The six ASCA core syndromes produced a two-factor…

  6. Ford Partnership for Advanced Studies (Ford PAS)

    ERIC Educational Resources Information Center

    Carrier, Cheryl

    2006-01-01

    This article features the Ford Partnership for Advanced Studies (Ford PAS) program that helps students gain knowledge about real-life business issues. Ford PAS is an educational program that combines college-prep academics with the critical 21st century skills students will need to succeed in college and in the workplace. The Ford PAS program uses…

  7. Nonlinear dynamics in a heterogeneous duopoly game with adjusting players and diseconomies of scale

    NASA Astrophysics Data System (ADS)

    Dubiel-Teleszynski, Tomasz

    2011-01-01

    A repeated, discrete time, heterogeneous Cournot duopoly game with bounded rational and adaptive players adjusting the quantities of production is subject of investigation. Linear inverse demand function and quadratic cost functions reflecting decreasing returns to scale are assumed. The game is modeled with a system of two difference equations. Evolution of outputs over time is obtained by iteration of a two dimensional nonlinear map. Existing equilibria and their stability are analyzed. In face of diseconomies of scale, bounded rational and adaptive duopolists are shown to experience a decrease in the latitude of their output adjustment decisions with respect to the market stability compared to constant returns to scale and ceteris paribus. Chaotic dynamics is confirmed to depend mainly on the adjustment behavior of the bounded rational player, who if overshoots leaves the adaptive player with limited opportunities to stabilize the market again, hence industries facing diseconomies of scale are found to be less stable than those with constant marginal costs. Complexity of the dynamical system is examined by means of numerical simulations, where the paper extends the results of other authors who considered analogous games assuming linear cost functions. Intermittent transition to chaos and attractor merging crisis are shown among others.

  8. Accuracy Validation of Large-scale Block Adjustment without Control of ZY3 Images over China

    NASA Astrophysics Data System (ADS)

    Yang, Bo

    2016-06-01

    Mapping from optical satellite images without ground control is one of the goals of photogrammetry. Using 8802 three linear array stereo images (a total of 26406 images) of ZY3 over China, we propose a large-scale and non-control block adjustment method of optical satellite images based on the RPC model, in which a single image is regarded as an adjustment unit to be organized. To overcome the block distortion caused by unstable adjustment without ground control and the excessive accumulation of errors, we use virtual control points created by the initial RPC model of the images as the weighted observations and add them into the adjustment model to refine the adjustment. We use 8000 uniformly distributed high precision check points to evaluate the geometric accuracy of the DOM (Digital Ortho Model) and DSM (Digital Surface Model) production, for which the standard deviations of plane and elevation are 3.6 m and 4.2 m respectively. The geometric accuracy is consistent across the whole block and the mosaic accuracy of neighboring DOM is within a pixel, thus, the seamless mosaic could take place. This method achieves the goal of an accuracy of mapping without ground control better than 5 m for the whole China from ZY3 satellite images.

  9. Regulation and function of yeast PAS kinase

    PubMed Central

    Grose, Julianne H.; Sundwall, Eleanor; Rutter, Jared

    2016-01-01

    The inability to coordinate cellular metabolic processes with the cellular and organismal nutrient environment leads to a variety of disorders, including diabetes and obesity. Nutrient-sensing protein kinases, such as AMPK and mTOR, play a pivotal role in metabolic regulation and are promising therapeutic targets for the treatment of disease. In this Extra View, we describe another member of the nutrient-sensing protein kinase group, PAS kinase, which plays a role in the regulation of glucose utilization in both mammals and yeast. PAS kinase deficient mice are resistant to high fat diet-induced weight gain, insulin resistance and hepatic triglyceride hyperaccumulation, suggesting a role for PAS kinase in the regulation of glucose and lipid metabolism in mammals. Likewise, PAS kinase deficient yeast display altered glucose partitioning, favoring glycogen biosynthesis at the expense of cell wall biosynthesis. As a result, PAS kinase deficient yeast are sensitive to cell wall perturbing agents. This partitioning of glucose in response to PAS kinase activation is due to phosphorylation of Ugp1, the enzyme primarily responsible for UDP-glucose production. The two yeast PAS kinase homologs, Psk1 and Psk2, are activated by two stimuli, cell integrity stress and nonfermentative carbon sources. We review what is known about yeast PAS kinase and describe a genetic screen that may help elucidate pathways involved in PAS kinase activation and function. PMID:19440050

  10. Retaining Large and Adjustable Elastic Strains of Kilogram-Scale Nb Nanowires.

    PubMed

    Hao, Shijie; Cui, Lishan; Wang, Hua; Jiang, Daqiang; Liu, Yinong; Yan, Jiaqiang; Ren, Yang; Han, Xiaodong; Brown, Dennis E; Li, Ju

    2016-02-10

    Individual metallic nanowires can sustain ultralarge elastic strains of 4-7%. However, achieving and retaining elastic strains of such magnitude in kilogram-scale nanowires are challenging. Here, we find that under active load, ∼ 5.6% elastic strain can be achieved in Nb nanowires embedded in a metallic matrix deforming by detwinning. Moreover, large tensile (2.8%) and compressive (-2.4%) elastic strains can be retained in kilogram-scale Nb nanowires when the external load was fully removed, and adjustable in magnitude by processing control. It is then demonstrated that the retained tensile elastic strains of Nb nanowires can increase their superconducting transition temperature and critical magnetic field, in comparison with the unstrained original material. This study opens new avenues for retaining large and tunable elastic strains in great quantities of nanowires and elastic-strain-engineering at industrial scale. PMID:26745016

  11. Coarse-scaling adjustment of fine-group neutron spectra for epithermal neutron beams in BNCT using multiple activation detectors

    NASA Astrophysics Data System (ADS)

    Liu, Yuan-Hao; Nievaart, Sander; Tsai, Pi-En; Liu, Hong-Ming; Moss, Ray; Jiang, Shiang-Huei

    2009-01-01

    In order to provide an improved and reliable neutron source description for treatment planning in boron neutron capture therapy (BNCT), a spectrum adjustment procedure named coarse-scaling adjustment has been developed and applied to the neutron spectrum measurements of both the Tsing Hua Open-pool Reactor (THOR) epithermal neutron beam in Taiwan and the High Flux Reactor (HFR) in The Netherlands, using multiple activation detectors. The coarse-scaling adjustment utilizes a similar idea as the well-known two-foil method, which adjusts the thermal and epithermal neutron fluxes according to the Maxwellian distribution for thermal neutrons and 1/ E distribution over the epithermal neutron energy region. The coarse-scaling adjustment can effectively suppress the number of oscillations appearing in the adjusted spectrum and provide better smoothness. This paper also presents a sophisticated 9-step process utilizing twice the coarse-scaling adjustment which can adjust a given coarse-group spectrum into a fine-group structure, i.e. 640 groups, with satisfactory continuity and excellently matched reaction rates between measurements and calculation. The spectrum adjustment algorithm applied in this study is the same as the well-known SAND-II.

  12. Use of the mini-MAC scale in the evaluation of mental adjustment to cancer

    PubMed Central

    Marek, Ewelina; Deptała, Andrzej

    2015-01-01

    Aim of the study The objective of the study was to evaluate mental adjustment to cancer in patients diagnosed with an oncologic disease through identification of the coping strategies they had adopted. Material and methods Seventy-four patients of the Clinic of Oncology and Haematology at the Central Clinical Hospital (CSK) of the Ministry of Interior (MSW) in Warsaw were included in the study. The degree of adaptation to cancer was evaluated with the use of the mini-Mental Adjustment to Cancer (mini-MAC) scale. The individual subscales, i.e. fighting spirit, positive redefinition, helplessness-hopelessness, and anxious preoccupation, were collated with socio-demographic characteristics. Results Study findings indicate that: 1) tumour patients typically manifest behaviour that allows one to identify their adjustment to cancer; 2) in malignant tumour patients constructive behaviour prevails over destructive behaviour; 3) the helplessness-hopelessness response is more pronounced in men than women; 4) metastatic patients manifest stronger helplessness-hopelessness response than patients with locally limited tumours; 5) pensioners more often than people of working age adopt the helplessness-hopelessness strategy; and 6) patients with the shortest disease period manifest the strongest fighting spirit. Conclusions Cancer patients employ various strategies of coping with disease depending on socio-demographic factors. PMID:26793028

  13. JPCam: Status of the 1.2Gpixel camera for the J-PAS survey.

    NASA Astrophysics Data System (ADS)

    Taylor, Keith; Marín-Franch, Antonio; Santoro, Fernando; Mendes de Oliveira, Claudia; Dupke, Renato

    2015-08-01

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k, 10 micron pixel detectors, to be deployed on the JST/T250, a dedicated 2.55m wide-field telescope at the OAJ (Observatorio Astrofísico de Javalambre) in Teruel, Spain. The camera is designed to perform the J-PAS, a BAO survey of the northern sky. The J-PAS survey strategy will use 59 filters, 56 relatively narrow-band (14.5nm) filters equi-spaced between 350 and 1000nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over 8000 square degrees of sky. The cryostat, detector mosaic and read electronics is being supplied by e2v. Each science detector is read from 16 ports simultaneously, allowing read times of 14s with a typical read noise of 5e- (rms). The JPCam focal plane will be complemented with 4 autoguiding and 8 wavefront sensing CCDs. Image quality over the whole CCD mosaic will be maintained by applying the required, close loop, focus, tilt and rotation adjustments to the focal plane through the JPCam hexapod actuator system, manufactured by NTE-Sener. The filter unit has been designed to admit 5 filter trays, each mounting 14 filters corresponding to the 14 CCDs of the mosaic. Each CCD will view only its corresponding filter avoiding optical cross-talk from their neighbors. With this configuration, JPCam will cover 4.7 square degrees with a plate scale of 0.2267 arcsec/pix and will allow all the J-PAS filters to be permanently installed on the camera. The massive 525mm aperture shutter is supplied by Bonn-Shutter UG.

  14. Reach-Scale Channel Adjustments to Channel Network Geometry in Mountain Bedrock Streams

    NASA Astrophysics Data System (ADS)

    Plitzuweit, S. J.; Springer, G. S.

    2008-12-01

    Channel network geometry (CNG) is a critical determinant of hydrological response and may significantly affect incision processes within the Appalachian Plateau near Richwood, West Virginia. The Williams, Cherry, and Cranberry Rivers share drainage divides and their lower reaches flow atop resistant, quartz-rich sandstones. The lower two-thirds of the Cranberry and Williams Rivers display linear profiles atop the sandstones; whereas the Cherry is concave upwards atop the sandstones. Because lithologies and geological structures are similar among the watersheds, we tested whether differences in CNGs explain the profile shapes and reach-scale channel properties. Specifically, we quantified CNG by calculating reach- specific area-distance functions using DEMs. The area-distance functions were then converted into synthetic hydrographs to model hydrological responses. The Cherry River exhibits a classic dendritic drainage pattern, producing peaked hydrographs and low interval transit times. The Cranberry River displays a trellis-like drainage pattern, which produces attenuated hydrographs and high interval transit times. The upstream reaches of the Williams River have a dendritic drainage pattern, but the lower two-thirds of the watershed transitions into an elongated basin with trellis-like CNG. Reach gradients are steeper in the lower reaches of the Williams and Cranberry Rivers where hydrographs are attenuated. In contrast, peaked hydrographs within the Cherry River are associated with lower reach gradients despite resistant sandstone channel beds. Trellis-like CNG may restrict the ability of downstream reaches within the Williams and Cranberry Rivers to achieve the critical discharge needed to cause incision during floods (all other things being equal). If so, increased reach gradients may be hydraulic adjustments that compensate for comparatively low discharges. We are now applying the synthetic hydrographs to HEC-RAS flow models generated from field channel

  15. Adjusting for population stratification in a fine scale with principal components and sequencing data.

    PubMed

    Zhang, Yiwei; Shen, Xiaotong; Pan, Wei

    2013-12-01

    Population stratification is of primary interest in genetic studies to infer human evolution history and to avoid spurious findings in association testing. Although it is well studied with high-density single nucleotide polymorphisms (SNPs) in genome-wide association studies (GWASs), next-generation sequencing brings both new opportunities and challenges to uncovering population structures in finer scales. Several recent studies have noticed different confounding effects from variants of different minor allele frequencies (MAFs). In this paper, using a low-coverage sequencing dataset from the 1000 Genomes Project, we compared a popular method, principal component analysis (PCA), with a recently proposed spectral clustering technique, called spectral dimensional reduction (SDR), in detecting and adjusting for population stratification at the level of ethnic subgroups. We investigated the varying performance of adjusting for population stratification with different types and sets of variants when testing on different types of variants. One main conclusion is that principal components based on all variants or common variants were generally most effective in controlling inflations caused by population stratification; in particular, contrary to many speculations on the effectiveness of rare variants, we did not find much added value with the use of only rare variants. In addition, SDR was confirmed to be more robust than PCA, especially when applied to rare variants. PMID:24123217

  16. Trigonometric Parallaxes and a Kinematically Adjusted Distance Scale for OB Associations

    NASA Astrophysics Data System (ADS)

    Dambis, A. K.; Mel'Nik, A. M.; Rastorguev, A. S.

    2001-01-01

    By directly comparing the photometric distances of Blaha and Humphreys (1989) (BH) to OB associations and field stars with the corresponding Hipparcos trigonometric parallaxes, we show that the BH distance scale is overestimated, on average, by 10-20%. This result is independently corroborated by applying the rigorous statistical-parallax method and its simplified analog (finding a kinematically adjusted rotation-curve solution from radial velocities and proper motions) to a sample of OB associations. These two methods lead us to conclude that the BH distance scale for OB associations should be shrunk, on average, by 11 +/- 6 and 24 +/- 10 %, respectively. Kinematical parameters have been determined for the system of OB associations: u_0 = 8.2 +/- 1.3 km/s, v_0= 11.9 +/- 1.1 km/s, w_0 = 9.5 +/- 0.9 km/s, sigma_u = 8.2 +/- 1.1 km/s, sigma_v = 5.8 +/- 0.8 km/s, sigma_w = 5.0 +/- 0.8 km/s, Omega_0 = 29.1 +/- 1.0 km/s/kpc, (Omega_0)' = -4.57 +/- 0.20 km/s/kpc^2, and (Omega_0)'' = 1.32 +/- 0.14 km/s/kpc^3. The distance scale for OB associations reduced by 20% matches the short Cepheid distance scale (Berdnikov and Efremov 1985; Sitnik and Mel'nik 1996). Our results are a further argument for the short distance scale in the Universe.

  17. Prediction of Delinquency, Adjustment, and Academic Achievement Over a Five Year Period with the Kvaraceus Delinquency Proneness Scale.

    ERIC Educational Resources Information Center

    Benning, James J.; And Others

    The Kvaraceus Delinquency Proneness Scale (KD Scale) was developed as an instrument designed to aid in prediction of future juvenile delinquents. The purpose of this research was to evaluate the predictive validity of the instrument over a 5-year period. Indexes of delinquency adjustment and academic achievement served as the validational…

  18. Evaluation of Logjam Scour in the Context of Reach-scale River Channel Adjustments

    NASA Astrophysics Data System (ADS)

    Hanrahan, T. P.; Vernon, C. R.

    2012-12-01

    River channel modifications for protection, enhancement and restoration often include flow resistance elements such as large wood and rock structures. Evaluating the effectiveness of these modifications in achieving design objectives can be confounded by river channel adjustments occurring at larger spatial scales throughout the reach of interest. Engineered logjams are one example where the design objectives typically include riverbed scour and the creation of pools. We surveyed riverbed elevations before and after the installation of engineered logjams, and compared those measurements to predictions from empirical scour equations. Riverbed elevations throughout the reach were also surveyed along cross-sections before and after restoration activities. River channel expansion and contraction throughout the reach was measured by mapping the unvegetated channel boundary for a period of years before and after restoration. Maximum riverbed scour immediately adjacent to the engineered logjams was 1.27 m, while maximum riverbed aggradation was 1.88 m. General riverbed scour and aggradation throughout the study reached was much larger, ranging from 2.71 m of scour to 2.96 m of aggradation. Over a period of 4 years, the channel expanded throughout the area of logjam installation, with increases in channel width ranging from 25.2 m to 58.2 m. Results from this study highlight the importance of considering large scale interactions between vegetation and river morphodynamics in the planning and implementation of river channel modifications.

  19. Construct Validity of the Kaufman Brief Intelligence Test, Wechsler Intelligence Scale for Children-Third Edition, and Adjustment Scales for Children and Adolescents

    ERIC Educational Resources Information Center

    Canivez, Gary L.; Neitzel, Ryan; Martin, Blake E.

    2005-01-01

    The present study reports data supporting the construct validity of the Kaufman Brief Intelligence Test (K-BIT; Kaufman & Kaufman, 1990), the Wechsler Intelligence Scale for Children-Third Edition (WISC-III; Wechsler, 1991), and the Adjustment Scales for Children and Adolescents (ASCA; McDermott, Marston, & Stott, 1993) through convergent and…

  20. The British Sign Language Versions of the Patient Health Questionnaire, the Generalized Anxiety Disorder 7-Item Scale, and the Work and Social Adjustment Scale

    ERIC Educational Resources Information Center

    Rogers, Katherine D.; Young, Alys; Lovell, Karina; Campbell, Malcolm; Scott, Paul R.; Kendal, Sarah

    2013-01-01

    The present study is aimed to translate 3 widely used clinical assessment measures into British Sign Language (BSL), to pilot the BSL versions, and to establish their validity and reliability. These were the Patient Health Questionnaire (PHQ-9), the Generalized Anxiety Disorder 7-item (GAD-7) scale, and the Work and Social Adjustment Scale (WSAS).…

  1. Development and Validation of a Brief Version of the Dyadic Adjustment Scale With a Nonparametric Item Analysis Model

    ERIC Educational Resources Information Center

    Sabourin, Stephane; Valois, Pierre; Lussier, Yvan

    2005-01-01

    The main purpose of the current research was to develop an abbreviated form of the Dyadic Adjustment Scale (DAS) with nonparametric item response theory. The authors conducted 5 studies, with a total participation of 8,256 married or cohabiting individuals. Results showed that the item characteristic curves behaved in a monotonically increasing…

  2. Assessing Changes in Socioemotional Adjustment across Early School Transitions--New National Scales for Children at Risk

    ERIC Educational Resources Information Center

    McDermott, Paul A.; Watkins, Marley W.; Rovine, Michael J.; Rikoon, Samuel H.

    2013-01-01

    This article reports the development and evidence for validity and application of the Adjustment Scales for Early Transition in Schooling (ASETS). Based on primary analyses of data from the Head Start Impact Study, a nationally representative sample (N = 3077) of randomly selected children from low-income households is configured to inform…

  3. Setting the PAS, the role of circadian PAS domain proteins during environmental adaptation in plants

    PubMed Central

    Vogt, Julia H. M.; Schippers, Jos H. M.

    2015-01-01

    The per-ARNT-sim (PAS) domain represents an ancient protein module that can be found across all kingdoms of life. The domain functions as a sensing unit for a diverse array of signals, including molecular oxygen, small metabolites, and light. In plants, several PAS domain-containing proteins form an integral part of the circadian clock and regulate responses to environmental change. Moreover, these proteins function in pathways that control development and plant stress adaptation responses. Here, we discuss the role of PAS domain-containing proteins in anticipation, and adaptation to environmental changes in plants. PMID:26217364

  4. Fracture-based Fabrication of Normally-closed, Adjustable and Fully Reversible Micro-scale Fluidic Channels

    PubMed Central

    Huang, Jiexi; Matsuoka, Toshiki; Thouless, M.D.; Takayama, Shuichi

    2014-01-01

    Adjustable fluidic structures play an important role in microfluidic systems. Fracture of multilayered materials under applied tension has been previously demonstrated as a convenient, simple and inexpensive approach to fabricate nano-scale adjustable structures; here, we demonstrate how to extend this concept to the micro-scale. We achieve this by a novel pairing of materials that leverages fracture mechanics to limit crack formation to a specified region, allowing us to create size-controllable and adjustable microfluidic structures. We demonstrate that this technique can be used to fabricate ‘normally-closed’ microfluidic channels that are completely reversible, a feature that is challenging to achieve in conventional systems without careful engineering controls. The adjustable microfluidic channels are then applied to mechanically lyse single cells, and subsequently manipulate the released nuclear chromatin, creating new possibilities for epigenetic analysis of single cells. This simple, versatile and robust technology provides an easily accessible pathway to construct adjustable microfluidic structures, which will be useful in developing complex assays and experiments even in resource-limited settings. PMID:24942855

  5. Les etoiles qui ne veulent pas vieillir

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    1995-12-01

    Qu'est-ce qui fait courir Jean-Claude Pecker ? Ses travaux sur les atmospheres stellaires qu'il poursuit aujourd'hui ? Son combat pour les droits de l'homme, ou contre le sceau du secret qui pese encore sur la recherche fondamentale ? Tout a la fois. Pour cette figure emblematique de l'astrophysique francaise, aujourd'hui a la retraite, pas question de raccrocher les armes...

  6. Least squares adjustment of large-scale geodetic networks by orthogonal decomposition

    SciTech Connect

    George, J.A.; Golub, G.H.; Heath, M.T.; Plemmons, R.J.

    1981-11-01

    This article reviews some recent developments in the solution of large sparse least squares problems typical of those arising in geodetic adjustment problems. The new methods are distinguished by their use of orthogonal transformations which tend to improve numerical accuracy over the conventional approach based on the use of the normal equations. The adaptation of these new schemes to allow for the use of auxiliary storage and their extension to rank deficient problems are also described.

  7. Propagation of biases in climate models from the synoptic to the regional scale: Implications for bias adjustment

    NASA Astrophysics Data System (ADS)

    Addor, Nans; Rohrer, Marco; Furrer, Reinhard; Seibert, Jan

    2016-03-01

    Bias adjustment methods usually do not account for the origins of biases in climate models and instead perform empirical adjustments. Biases in the synoptic circulation are for instance often overlooked when postprocessing regional climate model (RCM) simulations driven by general circulation models (GCMs). Yet considering atmospheric circulation helps to establish links between the synoptic and the regional scale, and thereby provides insights into the physical processes leading to RCM biases. Here we investigate how synoptic circulation biases impact regional climate simulations and influence our ability to mitigate biases in precipitation and temperature using quantile mapping. We considered 20 GCM-RCM combinations from the ENSEMBLES project and characterized the dominant atmospheric flow over the Alpine domain using circulation types. We report in particular a systematic overestimation of the frequency of westerly flow in winter. We show that it contributes to the generalized overestimation of winter precipitation over Switzerland, and this wet regional bias can be reduced by improving the simulation of synoptic circulation. We also demonstrate that statistical bias adjustment relying on quantile mapping is sensitive to circulation biases, which leads to residual errors in the postprocessed time series. Overall, decomposing GCM-RCM time series using circulation types reveals connections missed by analyses relying on monthly or seasonal values. Our results underscore the necessity to better diagnose process misrepresentation in climate models to progress with bias adjustment and impact modeling.

  8. Scale-Adjusted Metrics for Predicting the Evolution of Urban Indicators and Quantifying the Performance of Cities

    PubMed Central

    Alves, Luiz G. A.; Mendes, Renio S.; Lenzi, Ervin K.; Ribeiro, Haroldo V.

    2015-01-01

    More than a half of world population is now living in cities and this number is expected to be two-thirds by 2050. Fostered by the relevancy of a scientific characterization of cities and for the availability of an unprecedented amount of data, academics have recently immersed in this topic and one of the most striking and universal finding was the discovery of robust allometric scaling laws between several urban indicators and the population size. Despite that, most governmental reports and several academic works still ignore these nonlinearities by often analyzing the raw or the per capita value of urban indicators, a practice that actually makes the urban metrics biased towards small or large cities depending on whether we have super or sublinear allometries. By following the ideas of Bettencourt et al. [PLoS ONE 5 (2010) e13541], we account for this bias by evaluating the difference between the actual value of an urban indicator and the value expected by the allometry with the population size. We show that this scale-adjusted metric provides a more appropriate/informative summary of the evolution of urban indicators and reveals patterns that do not appear in the evolution of per capita values of indicators obtained from Brazilian cities. We also show that these scale-adjusted metrics are strongly correlated with their past values by a linear correspondence and that they also display crosscorrelations among themselves. Simple linear models account for 31%–97% of the observed variance in data and correctly reproduce the average of the scale-adjusted metric when grouping the cities in above and below the allometric laws. We further employ these models to forecast future values of urban indicators and, by visualizing the predicted changes, we verify the emergence of spatial clusters characterized by regions of the Brazilian territory where we expect an increase or a decrease in the values of urban indicators. PMID:26356081

  9. Scale-Adjusted Metrics for Predicting the Evolution of Urban Indicators and Quantifying the Performance of Cities.

    PubMed

    Alves, Luiz G A; Mendes, Renio S; Lenzi, Ervin K; Ribeiro, Haroldo V

    2015-01-01

    More than a half of world population is now living in cities and this number is expected to be two-thirds by 2050. Fostered by the relevancy of a scientific characterization of cities and for the availability of an unprecedented amount of data, academics have recently immersed in this topic and one of the most striking and universal finding was the discovery of robust allometric scaling laws between several urban indicators and the population size. Despite that, most governmental reports and several academic works still ignore these nonlinearities by often analyzing the raw or the per capita value of urban indicators, a practice that actually makes the urban metrics biased towards small or large cities depending on whether we have super or sublinear allometries. By following the ideas of Bettencourt et al. [PLoS ONE 5 (2010) e13541], we account for this bias by evaluating the difference between the actual value of an urban indicator and the value expected by the allometry with the population size. We show that this scale-adjusted metric provides a more appropriate/informative summary of the evolution of urban indicators and reveals patterns that do not appear in the evolution of per capita values of indicators obtained from Brazilian cities. We also show that these scale-adjusted metrics are strongly correlated with their past values by a linear correspondence and that they also display crosscorrelations among themselves. Simple linear models account for 31%-97% of the observed variance in data and correctly reproduce the average of the scale-adjusted metric when grouping the cities in above and below the allometric laws. We further employ these models to forecast future values of urban indicators and, by visualizing the predicted changes, we verify the emergence of spatial clusters characterized by regions of the Brazilian territory where we expect an increase or a decrease in the values of urban indicators. PMID:26356081

  10. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. These materials are incorporated as they exist on the date... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate...

  11. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. (These... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights,...

  12. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. (These... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights,...

  13. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. These materials are incorporated as they exist on the date... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate...

  14. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. These materials are incorporated as they exist on the date... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate...

  15. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. (These... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights,...

  16. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. These materials are incorporated as they exist on the date... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate...

  17. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. These materials are incorporated as they exist on the date... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate...

  18. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. (These... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights,...

  19. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. (These... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights,...

  20. Adjustments Made to the Results of the NWEA RIT Scale Minnesota Comprehensive Assessment Alignment Study

    ERIC Educational Resources Information Center

    Cronin, John

    2004-01-01

    Recently the Northwest Evaluation Association (NWEA) completed a project to connect the scale of the MCA and BST with NWEA's RIT scale. Six Minnesota systems participated in the study, using test information from a group of over 13,000 students enrolled in third, fifth, and eighth grades who took these Minnesota Assessments and NWEA tests in the…

  1. Assessing changes in socioemotional adjustment across early school transitions-new national scales for children at risk.

    PubMed

    McDermott, Paul A; Watkins, Marley W; Rovine, Michael J; Rikoon, Samuel H

    2013-02-01

    This article reports the development and evidence for validity and application of the Adjustment Scales for Early Transition in Schooling (ASETS). Based on primary analyses of data from the Head Start Impact Study, a nationally representative sample (N=3077) of randomly selected children from low-income households is configured to inform developmental-transitional stability and change in socioemotional adjustment. Longitudinal exploratory and confirmatory factor analysis of the ASETS revealed behavioral dimensions of Aggression, Attention Seeking, Reticence/Withdrawal, Low Energy, and higher-order dimensions of Overactivity and Underactivity. Each dimension was vertically equated through IRT, with Bayesian scoring across 2 years of prekindergarten, kindergarten, and 1st grade. Multilevel modeling provides evidence for concurrent validity, assessment of future risk, and detection of differential growth trajectories across the 4 years of early school transition. PMID:23375175

  2. Work Adjustment Theory: An Empirical Test Using a Fuzzy Rating Scale.

    ERIC Educational Resources Information Center

    Hesketh, Beryl; And Others

    1992-01-01

    A fuzzy graphic rating scale elicited work preferences and job perceptions of 166 (of 170) Australian bank employees. Correspondence between preferences and perceptions correlated significantly with job satisfaction. Satisfaction and performance related to tenure intentions; this relation was higher for poorer performers. (SK)

  3. Within-Semester Stability and Adjustment Correlates of the Multidimensional Perfectionism Scale.

    ERIC Educational Resources Information Center

    Rice, Kenneth G.; Dellwo, Jacqueline P.

    2001-01-01

    Subscale scores from R.O. Frost, P. Marten, C. Lahart, and R. Rosenblate's (1990) Mulitdimensional Perfectionism Scale were found to be moderately stable over a 10-week period. Associations between perfectionism and self-esteem, depression, and academic integration yielded mixed support for the criterion-related validity of the scores from this…

  4. Structure of the Weinberger Adjustment Inventory Self-Restraint scale and its relation to problem behaviors in adolescence.

    PubMed

    Farrell, A D; Sullivan, T N

    2000-12-01

    The authors examined the structure of the Weinberger Adjustment Inventory (WAI) Self-Restraint scale in derivation (n = 1,286) and cross-validation (n = 1,154) samples of mostly African American 6th graders in 3 urban schools. Four models were compared: (a) a 1-factor model; (b) a hierarchical model in which factors representing Impulse Control, Suppression of Aggression, Responsibility, and Consideration of Others were subsumed by a higher order factor; (c) a model that represented these 4 factors as correlated but distinct constructs; and (d) a model that excluded Consideration of Others from the higher order factor. Consistent support was found for the last model based on confirmatory factor analyses and latent-variable analyses examining the relations among self-restraint scales, drug use, delinquency, and aggression. These findings have implications for using the WAI, particularly in studies of adolescent problem behaviors. PMID:11147106

  5. Millenial scale changes in flood magnitude and frequency and the role of changes in channel adjustment.

    NASA Astrophysics Data System (ADS)

    Croke, Jacky; Thompson, Christopher; Denham, Robert; Haines, Heather; Sharma, Ashneel; Pietsch, Timothy

    2016-04-01

    With access to only limited gauging records (~ 37 years in eastern Australia), Australia like many parts of the globe is heavily constrained in its ability to meaningfully predict the magnitude and frequency of extreme flood events. Flood inundation data gathered during recent floods (2011 and 213) now forms an essential insight into how landscapes may respond to future floods and to guide planning and policy. This study presents the first singe-catchment flood reconstruction analyses in a region of recognised hydrological variability, as characterised by alternating extremes of floods and droughts. The resultant 'Big Flood' data set consists of a unique combination of high-resolution topographic data on landscape changes during recent floods, and a detailed reconstruction of both the timing and estimated magnitude of past food events derived using OSL dating of flood deposits from a range of sedimentary environments. While distinct flood and drought 'phases' are recognisable over the timescale of several thousand years, the extent to which these reflect changes in flood magnitude and/or frequency remains complicated by catchment-specific geomorphology. Issues of flood sample preservation are discussed in this talk within the context of geomorphic setting and notably non-linear variations in the capacity for channel adjustment. This talk outlines the key factors which must be considered in evaluating the role of climate, landuse change and geomorphology in informing flood risk management in Queensland.

  6. Reach-scale morphological adjustments and stages of channel evolution: The case of the Trebbia River (northern Italy)

    NASA Astrophysics Data System (ADS)

    Bollati, I. M.; Pellegrini, L.; Rinaldi, M.; Duci, G.; Pelfini, M.

    2014-09-01

    A multitemporal series of aerial photos and cross-section topographic surveys have been used to analyze reach-scale channel evolution along a segment (length of about 22 km) of the lower Trebbia River (Northern Italy) with the aims to investigate the relations between channel width vs. bed-level adjustments and to identify spatio-temporal patterns of stages of channel evolution. Dendrochronology was used to determine the age of tree establishment of riparian and island forests during channel evolution. We identified a first phase of major adjustments (1954-1992) following a series of disturbances, dominated by channel narrowing and bed incision. During the final stage of narrowing, woody vegetation establishment contributed to stabilize new floodplain or island surfaces. A period of partial morphological recovery occurred from 1992 to 2010, dominated by an inversion of trend of channel width. During the phase of partial recovery, a stage of widening combined with a continuation of bed incision was identified, and a last stage characterized by widening and initial aggradation was observed on the central portion of the study reaches. Suitability and differences of existing channel evolution models (CEMs) derived in other geographical contexts were discussed, and a specific conceptual model comprising four stages of channel evolution was developed for the lower Trebbia River.

  7. Comparison of reach-scale morphologic adjustment in confined and unconfined alluvial mountain rivers, Olympic Peninsula, Washington

    NASA Astrophysics Data System (ADS)

    Micheletty, P. D.; Goode, J.; Pierce, J. L.; Buffington, J. M.

    2011-12-01

    Over human time scales (10-1 - 102 yr), alluvial mountain rivers respond to changes in sediment input and discharge through adjustments in reach-scale morphology (width, depth, grain size, and, to some degree, slope). Channel confinement (valley-width relative to the bankfull channel width) in these systems can strongly influence the magnitude of channel response. We compared channel responsiveness to flood events (50-100 yr) within the last 5 years in unconfined and confined valley segments on the Olympic Peninsula, western Washington. Field measurements of cross-sectional averaged width and depth in 20 confined and 20 unconfined valleys are compared to the bankfull dimensions predicted from established downstream hydraulic geometry relationships for the region. We expect that measured bankfull geometry of confined reaches will be significantly greater than the predicted bankfull dimensions, which would suggest that the morphology of confined channels is more responsive to flood events. In unconfined channels floodplains are large enough to disperse over-bank flows, which can limit the effect of peak discharges on channel morphology, whereas confined channels are forced to disperse the extra energy exerted by peak flows into increased shear stress along their bed and banks. Results from this study can aid modeling efforts to predict future changes in channel geometry and aquatic habitat in response to climate change or land use at the basin scale.

  8. The Brief Self-Control Scale Predicts Jail Inmates’ Recidivism, Substance Dependence, and Post-Release Adjustment

    PubMed Central

    2015-01-01

    Previous research finds that self-control is positively associated with adaptive and negatively associated with maladaptive behavior. However, most previous studies employ cross-sectional designs, low-risk samples, and limited assessments of self-control. This study of 553 jail inmates examined the relationship of a valid measure of self-control (Brief Self-Control Scale; BSCS) completed upon incarceration with behavior before, during, and one year after incarceration. After controlling for positive impression management (PIM), self-control was negatively related to substance misuse, suicidality, risky sex, and criminal history prior to incarceration and post-release illegal substance misuse, recidivism, and positive adjustment. Lower self-control predicted increases in substance dependence at post-release compared to pre-incarceration. Self-control was not related to misbehavior during incarceration, nor alcohol use or HIV-risk behavior one year post-release. Results were consistent as a function of age, race, and gender. This study supports self-control as an important risk and protective factor in a sample of criminal offenders. PMID:24345712

  9. Feasibility of classification of clay minerals by using PAS

    NASA Astrophysics Data System (ADS)

    Honda, Y.; Yoshida, Y.; Akiyama, Y.; Nishijima, S.

    2015-06-01

    After the nuclear power plant disaster, the evaluation of radioactive Cs kept in soil, especially in clay minerals and the elucidation of its movement are urgent subjects to promote decontamination. It is known that the extractable level of Cs depends on the sort of clay minerals. We tried to find the characteristics of clay minerals belonging to phillosilicate group using positron annihilation spectroscopy (PAS) and the relationship between the results of PAS and the amounts of substantially extracted Cs from the clay minerals. The results showed that each clay mineral was found to be distinguishable from other clay minerals by PAS and the extraction rate of Cs was different among those clay minerals, however the direct correlation between the results of PAS and the extraction rates of Cs was not found.

  10. Competitive concerns bring PAs, NPs into triage area.

    PubMed

    2008-06-01

    The ED at Harborview Medical Center in Seattle has proven new competition doesn't have to mean a loss of business or staff members. They moved physician assistants (PAs) and nurse practitioners (NPs) into triage to compete with urgent care clinics. When you have a hard time attracting midlevel practitioners, examine the local market to see who is recruiting them. Create a small, separate area in triage where midlevel practitioners can treat patients with less serious conditions. Be flexible with the number of hours the PAs and NPs work. Be prepared to expand their hours as demand increases. PMID:18807298

  11. Bundle block adjustment of large-scale remote sensing data with Block-based Sparse Matrix Compression combined with Preconditioned Conjugate Gradient

    NASA Astrophysics Data System (ADS)

    Zheng, Maoteng; Zhang, Yongjun; Zhou, Shunping; Zhu, Junfeng; Xiong, Xiaodong

    2016-07-01

    In recent years, new platforms and sensors in photogrammetry, remote sensing and computer vision areas have become available, such as Unmanned Aircraft Vehicles (UAV), oblique camera systems, common digital cameras and even mobile phone cameras. Images collected by all these kinds of sensors could be used as remote sensing data sources. These sensors can obtain large-scale remote sensing data which consist of a great number of images. Bundle block adjustment of large-scale data with conventional algorithm is very time and space (memory) consuming due to the super large normal matrix arising from large-scale data. In this paper, an efficient Block-based Sparse Matrix Compression (BSMC) method combined with the Preconditioned Conjugate Gradient (PCG) algorithm is chosen to develop a stable and efficient bundle block adjustment system in order to deal with the large-scale remote sensing data. The main contribution of this work is the BSMC-based PCG algorithm which is more efficient in time and memory than the traditional algorithm without compromising the accuracy. Totally 8 datasets of real data are used to test our proposed method. Preliminary results have shown that the BSMC method can efficiently decrease the time and memory requirement of large-scale data.

  12. Odds per adjusted standard deviation: comparing strengths of associations for risk factors measured on different scales and across diseases and populations.

    PubMed

    Hopper, John L

    2015-11-15

    How can the "strengths" of risk factors, in the sense of how well they discriminate cases from controls, be compared when they are measured on different scales such as continuous, binary, and integer? Given that risk estimates take into account other fitted and design-related factors-and that is how risk gradients are interpreted-so should the presentation of risk gradients. Therefore, for each risk factor X0, I propose using appropriate regression techniques to derive from appropriate population data the best fitting relationship between the mean of X0 and all the other covariates fitted in the model or adjusted for by design (X1, X2, … , Xn). The odds per adjusted standard deviation (OPERA) presents the risk association for X0 in terms of the change in risk per s = standard deviation of X0 adjusted for X1, X2, … , Xn, rather than the unadjusted standard deviation of X0 itself. If the increased risk is relative risk (RR)-fold over A adjusted standard deviations, then OPERA = exp[ln(RR)/A] = RR(s). This unifying approach is illustrated by considering breast cancer and published risk estimates. OPERA estimates are by definition independent and can be used to compare the predictive strengths of risk factors across diseases and populations. PMID:26520360

  13. The Maladaptive Behavior Record (MBR): A Scale for the Analysis and Prediction of Community Adjustment and Recidivism of Offenders.

    ERIC Educational Resources Information Center

    Barton, Marlin; Jenkins, W. O.

    This report describes the Maladaptive Behavior Record (MBR), a behavioral assessment scale developed for use in a longitudinal follow-up study of released adult offenders. The scale focused upon the identification and specification of maladaptive behaviors that are associated with postrelease success or failure, and is valid for and predictive of…

  14. Procedures and acceptance criteria for PAS-1 cask inspections

    SciTech Connect

    Mercado, J.E.

    1998-09-09

    The procedures and acceptance criteria that comprise this document were prepared to support a one-time test to certify two PAS-1 casks in accordance with US Department of Energy Certificate of Compliance US A/9184/B(U), which was issued in 1998. The specific inspections addressed in this document are the visual weld inspection and a dimensional inspection of the primary containment vessel.

  15. Geodynamic Research at the Department of Planetary Geodesy, SRC PAS

    NASA Astrophysics Data System (ADS)

    Brzeziński, Aleksander; Jóźwik, Mieczysław; Kaczorowski, Marek; Kalarus, Maciej; Kasza, Damian; Kosek, Wiesław; Nastula, Jolanta; Szczerbowski, Zbigniew; Wińska, Małgorzata; Wronowski, Roman; Zdunek, Ryszard; Zieliński, Janusz B.

    2016-06-01

    The Department of Planetary Geodesy of the Space Research Centre PAS has been conducting research on a broad spectrum of problems within a field of global dynamics of the Earth. In this report we describe the investigations on selected subjects concerning polar motion (modeling and geophysical interpretation of the Chandler wobble, hydrological excitation of seasonal signals, search for optimal prediction methods), tectonic activity in the region of the Książ Geodynamic Laboratory of the SRC, and finally the new joint Polish-Italian project GalAc analyzing feasibility and usefulness of equipping second-generation Galileo satellites with accelerometers.

  16. Standardization of the Korean version of Mini-Mental Adjustment to Cancer (K-Mini-MAC) scale: factor structure, reliability and validity.

    PubMed

    Kang, Jee In; Chung, Hyun Cheol; Kim, Se Joo; Choi, Hye Jin; Ahn, Joong Bae; Jeung, Hei-Cheul; Namkoong, Kee

    2008-06-01

    Mental adjustment and coping affect the physical outcome and survival as well as quality of life in cancer patients. The Mini-Mental Adjustment to Cancer (Mini-MAC) scale is a new refined, economical and reliable self-rating instrument measuring cognitive and behavioral responses to cancer. The aim of this study was to evaluate the psychometric properties of the Mini-MAC in Korean cancer patients. A total of 208 cancer patients recruited from the Yonsei Cancer Center were assessed with the Mini-MAC and the Hospital Anxiety and Depression Scale (HADS). Principal component analysis with varimax rotation for the Korean version of Mini-MAC (K-Mini-MAC) confirmed four factors. Three had psychometric properties similar to Helpless-Hopeless (HH), Anxious Preoccupation (AP) and Cognitive Avoidance (CA) of the original Mini-MAC. A novel factor, named Positive Attitude, included items of both Fatalism (FA) and Fighting Spirit (FS) from the original version. The five subscales from the original version (AP, HH, FS, FA and CA) and Positive Attitude had acceptable internal reliabilities in our sample (Cronbach's alpha coefficient 0.50-0.86; correlation coefficient of test-retest 0.68-0.88). For the validity, significant interscale correlation was observed in the original five subscales and Positive Attitude. Each subscale including Positive Attitude was also significantly related to Depression and Anxiety of HADS. As a whole, the K-Mini-MAC was a reliable, valid and acceptable tool for Korean cancer patients. These findings can provide information about the cross-cultural validity of Mini-MAC scale's factor structure. Cultural differences were also discussed. PMID:17957732

  17. Delineating PAS-HAMP interaction surfaces and signalling-associated changes in the aerotaxis receptor Aer.

    PubMed

    Garcia, Darysbel; Watts, Kylie J; Johnson, Mark S; Taylor, Barry L

    2016-04-01

    The Escherichia coli aerotaxis receptor, Aer, monitors cellular oxygen and redox potential via FAD bound to a cytosolic PAS domain. Here, we show that Aer-PAS controls aerotaxis through direct, lateral interactions with a HAMP domain. This contrasts with most chemoreceptors where signals propagate along the protein backbone from an N-terminal sensor to HAMP. We mapped the interaction surfaces of the Aer PAS, HAMP and proximal signalling domains in the kinase-off state by probing the solvent accessibility of 129 cysteine substitutions. Inaccessible PAS-HAMP surfaces overlapped with a cluster of PAS kinase-on lesions and with cysteine substitutions that crosslinked the PAS β-scaffold to the HAMP AS-2 helix. A refined Aer PAS-HAMP interaction model is presented. Compared to the kinase-off state, the kinase-on state increased the accessibility of HAMP residues (apparently relaxing PAS-HAMP interactions), but decreased the accessibility of proximal signalling domain residues. These data are consistent with an alternating static-dynamic model in which oxidized Aer-PAS interacts directly with HAMP AS-2, enforcing a static HAMP domain that in turn promotes a dynamic proximal signalling domain, resulting in a kinase-off output. When PAS-FAD is reduced, PAS interaction with HAMP is relaxed and a dynamic HAMP and static proximal signalling domain convey a kinase-on output. PMID:26713609

  18. Comparison of two different passive air samplers (PUF-PAS versus SIP-PAS) to determine time-integrated average air concentration of volatile hydrophobic organic pollutants

    NASA Astrophysics Data System (ADS)

    Kim, Seung-Kyu; Park, Jong-Eun

    2014-06-01

    Despite remarkable achievements with r some chemicals, a field-measurement technique has not been advanced for volatile hydrophobic organic chemicals (HOCs) that are the subjects of international concern. This study assesses the applicability of passive air sampling (PAS) by comparing PUF-PAS and its modified SIP-PAS which was made by impregnating XAD-4 powder into PUF, overviewing the principles of PAS, screening sensitive parameters, and determining the uncertainty range of PAS-derived concentration. The PAS air sampling rate determined in this study, corrected by a co-deployed low-volume active air sampler (LAS) for neutral PFCs as model chemicals, was ˜1.2 m3 day-1. Our assessment shows that the improved sorption capacity in a SIP lengthens PAS deployment duration by expanding the linear uptake range and then enlarges the effective air sampling volume and detection frequency of chemicals at trace level. Consequently, volatile chemicals can be collected during sufficiently long times without reaching equilibrium when using SIP, while this is not possible for PUF. The most sensitive parameter to influence PAS-derived CA was an air-side mass transfer coefficient (kA), implying the necessity of spiking depuration chemicals (DCs) because this parameter is strongly related with meteorological conditions. Uncertainty in partition coefficients (KPSM-A or KOA) influences PAS-derived CA to a greater extent with regard to lower KPSM-A chemicals. Also, the PAS-derived CA has an uncertainty range of a half level to a 3-fold higher level of the calculated one. This work is expected to establish solid grounds for the improvement of field measurement technique of HOCs.

  19. Safety review of the DCS (Distributed Control System) controlled full scale SRAT/SME (Sludge Receipt Adjustment Tank/Slurry Mix Evaporator) for water runs

    SciTech Connect

    Hacker, B.A.

    1988-01-29

    This memorandum addresses safety concerns of the Full Scale Sludge Receipt Adjustment Tank/Slurry Mix Evaporator (SRAT/SME) resulting from the installation of the new Distributed Control System (DCS). The present configuration of the SRAT/SME with DCS has been determined to be safe for operational testing with water. Another memorandum will be written after experience has been gained during water runs for actual operation. Previous safety evaluations and process hazard reviews for this facility have addressed normal industrial safety hazards and hazards associated with formic acid handling and operation with organics in the feed. Process operation with the new DCS controls will be very similar to the earlier operation controlled by the Modicon programmable logic controller (PLC). The interlocks for the SRAT/SME that were in the PLC have been programmed into the new DCS and will be reviewed here. 6 refs.

  20. Adjustment disorder

    MedlinePlus

    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, Va: American Psychiatric Publishing. 2013. Powell AD. Grief, bereavement, and adjustment disorders. In: Stern TA, Rosenbaum ...

  1. Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides

    SciTech Connect

    Heintz, Udo; Meinhart, Anton; Winkler, Andreas

    2014-03-01

    Crystal structures of two truncated variants of the transcription factor PpsR from R. sphaeroides are presented that enabled the phasing of a triple PAS domain construct. Together, these structures reveal the importance of α-helical PAS extensions for multi-PAS domain-mediated protein oligomerization and function. Per–ARNT–Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few structures of multi-PAS proteins are known. Therefore, the molecular mechanism of multi-PAS domain-mediated protein oligomerization and function is poorly understood. The transcription factor PpsR from Rhodobacter sphaeroides is such a multi-PAS domain protein that, in addition to its three PAS domains, contains a glutamine-rich linker and a C-terminal helix–turn–helix DNA-binding motif. Here, crystal structures of two N-terminally and C-terminally truncated PpsR variants that comprise a single (PpsR{sub Q-PAS1}) and two (PpsR{sub N-Q-PAS1}) PAS domains, respectively, are presented and the multi-step strategy required for the phasing of a triple PAS domain construct (PpsR{sub ΔHTH}) is illustrated. While parts of the biologically relevant dimerization interface can already be observed in the two shorter constructs, the PpsR{sub ΔHTH} structure reveals how three PAS domains enable the formation of multiple oligomeric states (dimer, tetramer and octamer), highlighting that not only the PAS cores but also their α-helical extensions are essential for protein oligomerization. The results demonstrate that the long helical glutamine-rich linker of PpsR results from a direct fusion of the N-cap of the PAS1 domain with the C-terminal extension of the N-domain that

  2. Adjustable microforceps.

    PubMed

    Bao, J Y

    1991-04-01

    The commonly used microforceps have a much greater opening distance and spring resistance than needed. A piece of plastic ring or rubber band can be used to adjust the opening distance and reduce most of the spring resistance, making the user feel more comfortable and less fatigued. PMID:2051437

  3. Faux Pas Detection and Intentional Action in Asperger Syndrome. A Replication on a French Sample

    ERIC Educational Resources Information Center

    Zalla, Tiziana; Sav, Anca-Maria; Stopin, Astrid; Ahade, Sabrina; Leboyer, Marion

    2009-01-01

    In the present study, we investigated mindreading abilities in a group of adults with Asperger Syndrome (AS) by using the faux pas task, an advanced test of theory of mind (Baron-Cohen et al. (1999). "Journal of Autism and Developmental Disorders, 29," 407-418). The faux pas is a particular case of a non-intentional action reflecting an…

  4. Ligand binding PAS domains in a genomic, cellular, and structural context

    PubMed Central

    Henry, Jonathan T.; Crosson, Sean

    2012-01-01

    Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting chemotaxis proteins. Although these domains are highly divergent at the primary sequence level, the structures of dozens of PAS domains across a broad section of sequence space have been solved, revealing a conserved three-dimensional architecture. An all-versus-all alignment of 63 PAS structures demonstrates that the PAS domain family forms structural clades on the basis of two principal variables: (a) topological location inside or outside the plasma membrane and (b) the class of small molecule that they bind. The binding of a chemically diverse range of small-molecule metabolites is a hallmark of the PAS domain family. PAS ligand binding either functions as a primary cue to initiate a cellular signaling response or provides the domain with the capacity to respond to secondary physical or chemical signals such as gas molecules, redox potential, or photons. This review synthesizes the current state of knowledge of the structural foundations and evolution of ligand recognition and binding by PAS domains. PMID:21663441

  5. Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus

    PubMed Central

    2013-01-01

    Background The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequence similarity. To gain greater insight into the evolution of PDC/PAS domains present in the bacterial kingdom and staphylococci in specific, the PDC/PAS domains from the genomic sequences of 48 bacteria, representing 5 phyla, were identified using the sensitive search method based on HMM-to-HMM comparisons (HHblits). Results A total of 1,007 PAS domains and 686 PDC domains distributed over 1,174 proteins were identified. For 28 Gram-positive bacteria, the distribution, organization, and molecular evolution of PDC/PAS domains were analyzed in greater detail, with a special emphasis on the genus Staphylococcus. Compared to other bacteria the staphylococci have relatively fewer proteins (6–9) containing PDC/PAS domains. As a general rule, the staphylococcal genomes examined in this study contain a core group of seven PDC/PAS domain-containing proteins consisting of WalK, SrrB, PhoR, ArlS, HssS, NreB, and GdpP. The exceptions to this rule are: 1) S. saprophyticus lacks the core NreB protein; 2) S. carnosus has two additional PAS domain containing proteins; 3) S. epidermidis, S. aureus, and S. pseudintermedius have an additional protein with two PDC domains that is predicted to code for a sensor histidine kinase; 4) S. lugdunensis has an additional PDC containing protein predicted to be a sensor histidine kinase. Conclusions This comprehensive analysis demonstrates that variation in PDC/PAS domains among bacteria has limited correlations to the genome size or pathogenicity; however, our analysis established that bacteria having a motile phase in their life cycle have significantly more PDC/PAS-containing proteins. In addition, our analysis revealed a

  6. Shaft adjuster

    DOEpatents

    Harry, Herbert H.

    1989-01-01

    Apparatus and method for the adjustment and alignment of shafts in high power devices. A plurality of adjacent rotatable angled cylinders are positioned between a base and the shaft to be aligned which when rotated introduce an axial offset. The apparatus is electrically conductive and constructed of a structurally rigid material. The angled cylinders allow the shaft such as the center conductor in a pulse line machine to be offset in any desired alignment position within the range of the apparatus.

  7. Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis

    PubMed Central

    1994-01-01

    Several groups have reported the cloning and sequencing of genes involved in the biogenesis of yeast peroxisomes. Yeast strains bearing mutations in these genes are unable to grow on carbon sources whose metabolism requires peroxisomes, and these strains lack morphologically normal peroxisomes. We report the cloning of Pichia pastoris PAS1, the homologue (based on a high level of protein sequence similarity) of the Saccharomyces cerevisiae PAS1. We also describe the creation and characterization of P. pastoris pas1 strains. Electron microscopy on the P. pastoris pas1 cells revealed that they lack morphologically normal peroxisomes, and instead contain membrane-bound structures that appear to be small, mutant peroxisomes, or "peroxisome ghosts." These "ghosts" proliferated in response to induction on peroxisome-requiring carbon sources (oleic acid and methanol), and they were distributed to daughter cells. Biochemical analysis of cell lysates revealed that peroxisomal proteins are induced normally in pas1 cells. Peroxisome ghosts from pas1 cells were purified on sucrose gradients, and biochemical analysis showed that these ghosts, while lacking several peroxisomal proteins, did import varying amounts of several other peroxisomal proteins. The existence of detectable peroxisome ghosts in P. pastoris pas1 cells, and their ability to import some proteins, stands in contrast with the results reported by Erdmann et al. (1991) for the S. cerevisiae pas1 mutant, in which they were unable to detect peroxisome-like structures. We discuss the role of PAS1 in peroxisome biogenesis in light of the new information regarding peroxisome ghosts in pas1 cells. PMID:7962088

  8. Postural Assessment Software (PAS/SAPO): Validation and Reliabiliy

    PubMed Central

    Ferreira, Elizabeth Alves G.; Duarte, Marcos; Maldonado, Edison Puig; Burke, Thomaz Nogueira; Marques, Amelia Pasqual

    2010-01-01

    OBJECTIVE: This study was designed to estimate the accuracy of the postural assessment software (PAS/SAPO) for measurement of corporal angles and distances as well as the inter- and intra-rater reliabilities. INTRODUCTION: Postural assessment software was developed as a subsidiary tool for postural assessment. It is easy to use and available in the public domain. Nonetheless, validation studies are lacking. METHODS: The study sample consisted of 88 pictures from 22 subjects, and each subject was assessed twice (1 week interval) by 5 blinded raters. Inter- and intra-rater reliabilities were estimated using the intraclass correlation coefficient. To estimate the accuracy of the software, an inanimate object was marked with hallmarks using pre-established parameters. Pictures of the object were rated, and values were checked against the known parameters. RESULTS: Inter-rater reliability was excellent for 41% of the variables and very good for 35%. Ten percent of the variables had acceptable reliability, and 14% were defined as non-acceptable. For intra-rater reliability, 44.8% of the measurements were considered to be excellent, 23.5% were very good, 12.4% were acceptable and 19.3% were considered non-acceptable. Angular measurements had a mean error analisys of 0.11°, and the mean error analisys for distance was 1.8 mm. DISCUSSION: Unacceptable intraclass correlation coefficient values typically used the vertical line as a reference, and this may have increased the inaccuracy of the estimates. Increased accuracies were obtained by younger raters with more sophisticated computer skills, suggesting that past experience influenced results. CONCLUSION: The postural assessment software was accurate for measuring corporal angles and distances and should be considered as a reliable tool for postural assessment. PMID:20668624

  9. Changes at the KinA PAS-A Dimerization Interface Influence Histidine Kinase Function

    SciTech Connect

    Lee, James; Tomchick, Diana R.; Brautigam, Chad A.; Machius, Mischa; Kort, Remco; Hellingwerf, Klaas J.; Gardner, Kevin H.

    2008-11-12

    The Bacillus subtilis KinA protein is a histidine protein kinase that controls the commitment of this organism to sporulate in response to nutrient deprivation and several other conditions. Prior studies indicated that the N-terminal Per-ARNT-Sim domain (PAS-A) plays a critical role in the catalytic activity of this enzyme, as demonstrated by the significant decrease of the autophosphorylation rate of a KinA protein lacking this domain. On the basis of the environmental sensing role played by PAS domains in a wide range of proteins, including other bacterial sensor kinases, it has been suggested that the PAS-A domain plays an important regulatory role in KinA function. We have investigated this potential by using a combination of biophysical and biochemical methods to examine PAS-A structure and function, both in isolation and within the intact protein. Here, we present the X-ray crystal structure of the KinA PAS-A domain, showing that it crystallizes as a homodimer using {beta}-sheet/{beta}-sheet packing interactions as observed for several other PAS domain complexes. Notably, we observed two dimers with tertiary and quaternary structure differences in the crystalline lattice, indicating significant structural flexibility in these domains. To confirm that KinA PAS-A also forms dimers in solution, we used a combination of NMR spectroscopy, gel filtration chromatography, and analytical ultracentrifugation, the results of which are all consistent with the crystallographic results. We experimentally tested the importance of several residues at the dimer interface using site-directed mutagenesis, finding changes in the PAS-A domain that significantly alter KinA enzymatic activity in vitro and in vivo. These results support the importance of PAS domains within KinA and other histidine kinases and suggest possible routes for natural or artificial regulation of kinase activity.

  10. Orthotopic Human Choroidal Melanoma Xenografts in Nude Rats with Aggressive and Nonaggressive PAS Staining Patterns

    PubMed Central

    Braun, Rod D.; Abbas, Asad

    2007-01-01

    PURPOSE Choroidal melanoma is the most common primary ocular cancer among the adult population. Patient survival has been linked to the periodic acid-Schiff base (PAS)–positive vascular patterns in the tumors. The presence of PAS-positive loops or cross-linking parallel channels is a marker of an aggressive tumor. The purpose of this study was to develop new xenograft models of human choroidal melanoma that predictably demonstrate the PAS staining patterns associated with nonaggressive and aggressive tumors in humans. METHODS Three human choroidal melanoma cell lines (C918, M619, and OCM-1) were used. C918 and M619 are considered aggressive, based on their ability to form PAS-positive channels in vitro. The nonaggressive OCM-1 cells do not form these channels. C918, M619, and OCM-1 spheroids were grown and implanted in the suprachoroidal space of 20, 17, and 16 WAG/RijHs-rnu nude rats, respectively. Tumors were grown for 1 to >4 weeks, and histology was performed to evaluate tumor growth and determine PAS labeling patterns. RESULTS Growth of C918, M619, and OCM-1 xenografts were histologically verified in 20/20, 15/17, and 16/16 rats, respectively. PAS staining revealed loops and cross-linking parallel channels, typical of aggressive tumors in patients, in 90% of C918 and 100% of M619 xenografts. Only 4 of 16 OCM-1 xenografts showed PAS-positive loops. The rest showed no PAS staining or only perivascular staining, indicative of nonaggressive tumors. CONCLUSIONS It is possible to grow human choroidal melanoma orthotopic xenografts in nude rats that reproduce the PAS staining patterns associated with aggressive and nonaggressive choroidal melanomas in patients. PMID:16384938

  11. Reliability of the ICD 10 version of the Psychiatric Assessment Schedule for Adults with Developmental Disability (PAS-ADD).

    PubMed

    Costello, H; Moss, S; Prosser, H; Hatton, C

    1997-08-01

    The Psychiatric Assessment Schedule for Adults with Developmental Disability (PAS-ADD) is a semi-structured clinical interview designed for use with respondents who have learning disability. The first version was based on the Present State Examination. The revised version was derived from the Schedules for Clinical Assessment in Neuropsychiatry (SCAN), and makes ICD 10 diagnoses using the SCAN diagnostic program. This current version has a 4-point scale of severity, compared with the 3-point scale of the first version. It also has a new module relating to psychotic disorders. The sample consisted of 40 individuals representing a spectrum of neurotic, depressive and psychotic disorders. Videotapes of 40 PAS-ADD interviews were re-rated by trained interviewers who had not been involved in the original study in which the videotapes were produced. The mean Kappa across all individual item codes was 0.65, ranging from 0.94 to 0.35. The mean Kappa agreement on item groups was 0.66. Correlation between total symptom scores was 0.74. Agreement on index of definition was Kappa 0.70. We concluded that, agreement was generally lower than for the ICD 9 version. This was probably due mainly to the increase in the severity categories from three to four. However, the new items (most of which related to psychosis) were of comparable reliability to other items. PMID:9299928

  12. Large variations in diurnal and seasonal patterns of sap flux among Aleppo pine trees in semi-arid forest reflect tree-scale hydraulic adjustments

    NASA Astrophysics Data System (ADS)

    Preisler, Yakir; Tatarinov, Fyodor; Rohatyn, Shani; Rotenberg, Eyal; Grünzweig, José M.; Klein, Tamir; Yakir, Dan

    2015-04-01

    Adjustments and adaptations of trees to drought vary across different biomes, species and habitats, with important implications for tree mortality and forest dieback associated with global climate change. The aim of this study was to investigate possible links between the patterns of variations in water flux dynamics and drought resistance in Aleppo pine (Pinus halepensis) trees in a semi-arid stand (Yatir forest, Israel). We measured sap flow (SF) and variations in stem diameter, complemented with short-term campaigns of leaf-scale measurements of water vapour and CO2 gas exchange, branch water potential and hydraulic conductivity, as well as eddy flux measurements of evapotranspiration (ET) from a permanent flux tower at the site. SF rates were well synchronized with ET, reaching maximum rates during midday in all trees during the rainy season (Dec-Apr). However, during the dry season (May-Nov), the daily trend in the rates of SF greatly varied among trees, allowing classification into three tree classes: 1) trees with SF maximum rate constantly occurring in mid-day (12:00-13:00); 2)trees showing a shift to an early morning SF peak (04:00-06:00); and 3) trees shifting their daily SF peak to the evening (16:00-18:00). This classification did not change during the four years study period, between 2010 and 2014. Checking for correlation of tree parameters as DBH, tree height, crown size, and competition indices with rates of SF, indicated that timing of maximum SF in summer was mainly related to tree size (DBH), when large trees tended to have a later SF maximum. Dendrometer measurements indicated that large trees (high DBH) had maximum daily diameter in the morning during summer and winter, while small trees typically had maximum daily diameter during midday and afternoon in winter and summer, respectively. Leaf-scale transpiration (T) measurements showed typical morning peak in all trees, and another peak in the afternoon in large trees only. Different diurnal

  13. 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

    PubMed

    Steele, Andrew J; Prentice, Archibald G; Hoffbrand, A Victor; Yogashangary, Birunthini C; Hart, Stephen M; Lowdell, Mark W; Samuel, Edward R; North, Janet M; Nacheva, Elisabeth P; Chanalaris, Anastasios; Kottaridis, Panagiotis; Cwynarski, Kate; Wickremasinghe, R Gitendra

    2009-08-01

    We studied the actions of 2-phenylacetylenesulfonamide (PAS) on B-chronic lymphocytic leukemia (CLL) cells. PAS (5-20 microM) initiated apoptosis within 24 hours, with maximal death at 48 hours asassessed by morphology, cleavage of poly(ADP-ribose) polymerase (PARP), caspase 3 activation, and annexin V staining. PAS treatment induced Bax proapoptotic conformational change, Bax movement from the cytosol to the mitochondria, and cytochrome c release, indicating that PAS induced apoptosis via the mitochondrial pathway. PAS induced approximately 3-fold up-regulation of proapoptotic Noxa protein and mRNA levels. In addition, Noxa was found unexpectedly to be bound to Bcl-2 in PAS-treated cells. PAS treatment of CLL cells failed to up-regulate p53, suggesting that PAS induced apoptosis independently of p53. Furthermore, PAS induced apoptosis in CLL isolates with p53 gene deletion in more than 97% of cells. Normal B lymphocytes were as sensitive to PAS-induced Noxa up-regulation and apoptosis as were CLL cells. However, both T lymphocytes and bone marrow hematopoietic progenitor cells were relatively resistant to PAS. Our data suggest that PAS may represent a novel class of drug that induces apoptosis in CLL cells independently of p53 status by a mechanism involving Noxa up-regulation. PMID:19515722

  14. Protein Dynamics of the HIF-2α PAS-B Domain upon Heterodimerization and Ligand Binding

    PubMed Central

    Masetti, Matteo; Falchi, Federico; Recanatini, Maurizio

    2014-01-01

    Hypoxia-Inducible Factor (HIF) transcription factors are heterodimeric proteins involved in the regulation of oxygen homeostatis. Their upregulation has been related to several tumors with a remarkably poor clinical outcome. The recent discovery of a druggable cavity in the HIF-2α PAS-B domain has opened an unprecedented opportunity for targeting the HIF-2α transcription factor in view of pharmaceutical strategies. Coincidentally, a novel compound able to selectively disrupt the HIF heterodimerization with a submicromolar activity has been reported. In this work, we investigated the molecular mechanisms responsible for the inhibition by comparing the dynamical features of the HIF-2α PAS-B monomer and the HIF-2α PAS-B/HIF-1β PAS-B complex, in the ligand-bound and -unbound states. Plain and biased Molecular Dynamics were used to characterize the differential conformational changes both structurally and energetically. PMID:24736273

  15. Toronto Psoriatic Arthritis Screening (ToPAS) questionnaire: a report from the GRAPPA 2009 annual meeting.

    PubMed

    Chandran, Vinod; Gladman, Dafna D

    2011-03-01

    The Toronto Psoriatic Arthritis Screening questionnaire (ToPAS) was developed as a tool to screen for psoriatic arthritis (PsA) in patients with psoriasis as well as in the general population. Thus, it differs from PsA-specific screening tools and may be used to screen for PsA in epidemiologic and family investigations. In a presentation at the 2009 annual meeting of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) in Stockholm, Sweden, the authors described the development, testing, and validation of the ToPAS tool. Results of a comparison of the ToPAS questionnaire with the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire were also presented. Modification and further validation of the ToPAS are under way. PMID:21362783

  16. Third Annual Maintenance Inspection & Test Report for PAS-1 Cask Certification for Shipping Payload B

    SciTech Connect

    KELLY, D.L.

    2001-11-01

    This, Third Annual Maintenance, Inspection, and Test Report for PAS-1 Cask Certification for Shipping Payload B, documents the successful completion of maintenance, testing, and inspections for two casks, serial numbers 2161-026 and 2162-027.

  17. J-PAS : Low-resolution (R ~ 50) spectroscopy covering 8000 deg2

    NASA Astrophysics Data System (ADS)

    López-Sanjuan, C.; Cenarro, A. J.; Díaz-García, L. A.; Muniesa, D. J.; San Roman, I.; Varela, J.; Viironen, K.

    2015-02-01

    We present the ambitious project J-PAS, that will cover 8000 deg2 of the northern sky with 54 narrow-band (~145Å) contiguous filters, all of them in the optical range (3700Å-9200Å). J-PAS will provide a low resolution spectra (R ~ 50) in every pixel of the northern sky by 2020, leading to excellent photometric redshifts (0.3% uncertainty) of 100 million sources. J-PAS will permit the study of the 2D properties of nearby galaxies with unprecedented statistics. Some viable studies are the distribution of the star formation rate traced by Hα, the stellar populations gradients in elliptical galaxies up to a few effective radii, or the impact of environment in galaxy properties. In summary, J-PAS will bring a superb data set for 3D analysis in the local Universe.

  18. Changes in Quaternary Structure in the Signaling Mechanisms of PAS Domains

    SciTech Connect

    Ayers, Rebecca A.; Moffat, Keith

    2008-12-15

    FixL from Bradyrhizobium japonicum is a PAS sensor protein in which two PAS domains covalently linked to a histidine kinase domain are responsible for regulating nitrogen fixation in an oxygen-dependent manner. The more C-terminal PAS domain, denoted bjFixLH, contains a heme cofactor that binds diatomic molecules such as carbon monoxide and oxygen and regulates the activity of the FixL histidine kinase as part of a two-component signaling system. We present the structures of ferric, deoxy, and carbon monoxide-bound bjFixLH in a new space group (P1) and at resolutions (1.5--1.8 {angstrom}) higher than the resolutions of those previously obtained. Interestingly, bjFixLH can form two different dimers (in P1 and R32 crystal forms) in the same crystallization solution, where the monomers in one dimer are rotated {approx}175 deg. relative to the second. This suggests that PAS monomers are plastic and that two quite distinct quaternary structures are closely similar in free energy. We use screw rotation analysis to carry out a quantitative pairwise comparison of PAS quaternary structures, which identifies five different relative orientations adopted by isolated PAS monomers. We conclude that PAS monomer arrangement is context-dependent and could differ depending on whether the PAS domains are isolated or are part of a full-length protein. Structurally homologous residues comprise a conserved dimer interface. Using network analysis, we find that the architecture of the PAS dimer interface is continuous rather than modular; the network of residues comprising the interface is strongly connected. A continuous dimer interface is consistent with the low dimer-monomer dissociation equilibrium constant. Finally, we quantitate quaternary structural changes induced by carbon monoxide binding to a bjFixLH dimer, in which monomers rotate by up to 2 deg. relative to each other. We relate these changes to those in other dimeric PAS domains and discuss the role of quaternary structural

  19. Changes in quaternary structure in the signaling mechanisms of PAS domains.

    PubMed

    Ayers, Rebecca A; Moffat, Keith

    2008-11-18

    FixL from Bradyrhizobium japonicum is a PAS sensor protein in which two PAS domains covalently linked to a histidine kinase domain are responsible for regulating nitrogen fixation in an oxygen-dependent manner. The more C-terminal PAS domain, denoted bjFixLH, contains a heme cofactor that binds diatomic molecules such as carbon monoxide and oxygen and regulates the activity of the FixL histidine kinase as part of a two-component signaling system. We present the structures of ferric, deoxy, and carbon monoxide-bound bjFixLH in a new space group ( P1) and at resolutions (1.5-1.8 A) higher than the resolutions of those previously obtained. Interestingly, bjFixLH can form two different dimers (in P1 and R32 crystal forms) in the same crystallization solution, where the monomers in one dimer are rotated approximately 175 degrees relative to the second. This suggests that PAS monomers are plastic and that two quite distinct quaternary structures are closely similar in free energy. We use screw rotation analysis to carry out a quantitative pairwise comparison of PAS quaternary structures, which identifies five different relative orientations adopted by isolated PAS monomers. We conclude that PAS monomer arrangement is context-dependent and could differ depending on whether the PAS domains are isolated or are part of a full-length protein. Structurally homologous residues comprise a conserved dimer interface. Using network analysis, we find that the architecture of the PAS dimer interface is continuous rather than modular; the network of residues comprising the interface is strongly connected. A continuous dimer interface is consistent with the low dimer-monomer dissociation equilibrium constant. Finally, we quantitate quaternary structural changes induced by carbon monoxide binding to a bjFixLH dimer, in which monomers rotate by up to approximately 2 degrees relative to each other. We relate these changes to those in other dimeric PAS domains and discuss the role of

  20. PAS-cal: a Generic Recombinant Peptide Calibration Standard for Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Breibeck, Joscha; Serafin, Adam; Reichert, Andreas; Maier, Stefan; Küster, Bernhard; Skerra, Arne

    2014-08-01

    We describe the design, preparation, and mass-spectrometric characterization of a new recombinant peptide calibration standard with uniform biophysical and ionization characteristics for mass spectrometry. "PAS-cal" is an artificial polypeptide concatamer of peptide cassettes with varying lengths, each composed of the three small, chemically stable amino acids Pro, Ala, and Ser, which are interspersed by Arg residues to allow site-specific cleavage with trypsin. PAS-cal is expressed at high yields in Escherichia coli as a Small Ubiquitin-like MOdifier (SUMO) fusion protein, which is easily purified and allows isolation of the PAS-cal moiety after SUMO protease cleavage. Upon subsequent in situ treatment with trypsin, the PAS-cal polypeptide yields a set of four defined homogeneous peptides in the range from 2 to 8 kDa with equal mass spacing. ESI-MS analysis revealed a conveniently interpretable raw spectrum, which after deconvolution resulted in a very simple pattern of four peaks with similar ionization signals. MALDI-MS analysis of a PAS-cal peptide mixture comprising both the intact polypeptide and its tryptic fragments revealed not only the four standard peptides but also the singly and doubly charged states of the intact concatamer as well as di- and trimeric adduct ion species between the peptides, thus augmenting the observable m/z range. The advantageous properties of PAS-cal are most likely a result of the strongly hydrophilic and conformationally disordered PEG-like properties of the PAS sequences. Therefore, PAS-cal offers an inexpensive and versatile recombinant peptide calibration standard for mass spectrometry in protein/peptide bioanalytics and proteomics research, the composition of which may be further adapted to fit individual needs.

  1. Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes

    PubMed Central

    Upadhyay, Amit A.; Fleetwood, Aaron D.; Adebali, Ogun; Finn, Robert D.; Zhulin, Igor B.

    2016-01-01

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly built computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms. Furthermore, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes. PMID:27049771

  2. Evaluating the PAS-SIM model using a passive air sampler calibration study for pesticides.

    PubMed

    Restrepo, Andrés Ramírez; Hayward, Stephen J; Armitage, James M; Wania, Frank

    2015-07-01

    The main objective of this study was to evaluate the performance of a model for simulating the uptake of various pesticides on passive air samplers (PAS). From 2006-2007 a series of PAS using XAD-resin were deployed at Egbert, a rural agricultural site in southern Ontario, Canada, to measure the uptake of pesticides for time periods ranging from two months to one year. A continuous increase in sequestered amounts was observed for most pesticides, except for trifluralin and pendimethalin, which could conceivably be subject to substantial degradation inside the sampler. Continuous low-volume active air samples taken during the same period, along with data on weather conditions, allowed for the simulation of the uptake of the pesticides using the model (PAS-SIM). The modelled accumulation of pesticides on the PAS over the deployment period was in good agreement with the experimental data in most cases (i.e., within a factor of two) providing insight into the uptake kinetics of this type of sampler in the field. Passive sampling rates (PSR, m(3) d(-1)) were determined from the empirical data generated for this study using three different methods and compared with the PSRs generated by the model. Overall, the PAS-SIM model, which is capable of accounting for the influence of temperature and wind variations on PSRs, provided reasonable results that range between the three empirical approaches employed and well-established literature values. Further evaluation and application of the PAS-SIM model to explore the potential spatial and temporal variability in PAS uptake kinetics is warranted, particularly for established monitoring sites where detailed meteorological data are more likely to be available. PMID:26083201

  3. Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq

    PubMed Central

    Shepard, Peter J.; Choi, Eun-A; Lu, Jente; Flanagan, Lisa A.; Hertel, Klemens J.; Shi, Yongsheng

    2011-01-01

    Alternative polyadenylation (APA) of mRNAs has emerged as an important mechanism for post-transcriptional gene regulation in higher eukaryotes. Although microarrays have recently been used to characterize APA globally, they have a number of serious limitations that prevents comprehensive and highly quantitative analysis. To better characterize APA and its regulation, we have developed a deep sequencing-based method called Poly(A) Site Sequencing (PAS-Seq) for quantitatively profiling RNA polyadenylation at the transcriptome level. PAS-Seq not only accurately and comprehensively identifies poly(A) junctions in mRNAs and noncoding RNAs, but also provides quantitative information on the relative abundance of polyadenylated RNAs. PAS-Seq analyses of human and mouse transcriptomes showed that 40%–50% of all expressed genes produce alternatively polyadenylated mRNAs. Furthermore, our study detected evolutionarily conserved polyadenylation of histone mRNAs and revealed novel features of mitochondrial RNA polyadenylation. Finally, PAS-Seq analyses of mouse embryonic stem (ES) cells, neural stem/progenitor (NSP) cells, and neurons not only identified more poly(A) sites than what was found in the entire mouse EST database, but also detected significant changes in the global APA profile that lead to lengthening of 3′ untranslated regions (UTR) in many mRNAs during stem cell differentiation. Together, our PAS-Seq analyses revealed a complex landscape of RNA polyadenylation in mammalian cells and the dynamic regulation of APA during stem cell differentiation. PMID:21343387

  4. Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor PAS-A Domain

    PubMed Central

    Wu, Dalei; Potluri, Nalini; Kim, Youngchang

    2013-01-01

    The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to xenobiotics and responds by regulating the expression of gene programs required for detoxification and metabolism. AHR and its heterodimerization partner aryl hydrocarbon receptor nuclear translocator (ARNT) belong to the basic helix-loop-helix (bHLH)–PER-ARNT-SIM (PAS) family of transcription factors. Here we report the 2.55-Å-resolution crystal structure of the mouse AHR PAS-A domain, which represents the first AHR-derived protein structure. The AHR PAS-A domain forms a helix-swapped homodimer in the crystal and also in solution. Through a detailed mutational analysis of all interface residues, we identified several hydrophobic residues that are important for AHR dimerization and function. Our crystallographic visualization of AHR PAS-A dimerization leads us to propose a mode of heterodimerization with ARNT that is supported by both biochemical and cell-based data. Our studies also highlight the residues of other mammalian bHLH-PAS proteins that are likely involved in their homo- or heterodimerization. PMID:24001774

  5. Psychometric evaluation of two new parent-rating scales for measuring anxiety symptoms in young Dutch children.

    PubMed

    Broeren, Suzanne; Muris, Peter

    2008-08-01

    The current study examined the reliability and validity of the Preschool Anxiety Scale (PAS) and the Children's Moods Fears and Worries Questionnaire (CMFWQ) in a Dutch community sample of 275 preschool children aged 2-6 years. The acceptability of PAS and CMFWQ items was good. Preliminary exploratory factor analyses yielded a meaningful five-factor model for the PAS and a three-factor model for the CMFWQ. PAS scales had moderate to high reliability coefficients (alphas between .59 and .86), whereas CMFWQ scales displayed good internal consistency (alphas between .88 and .95). The validity of both measures was supported by a number of findings. First, PAS and CMFWQ scores were substantially correlated. Particularly high correlations were found between the PAS total scale and CMFWQ fear and anxiety problems. Second, PAS and CMFWQ scores were also correlated with CBCL emotionally reactive, anxious/depressed and withdrawn subscales. Third, girls displayed significantly higher scores on the PAS scales than boys, which is in agreement with previous research. Also some age differences were found on the PAS, with older children scoring higher on the social phobia and generalized anxiety disorder subscales than younger children. Finally, CMFWQ and PAS scores discriminated reasonably between children scoring in the normal, subclinical and clinical range of the CBCL subscales. The utility of the PAS and the CMFWQ as a screening instrument for anxiety problems in preschoolers is briefly discussed. PMID:17977693

  6. Language and Adjustment Scales for the Thematic Apperception Test for Youths 12-17 Years. Vital Health and Statistics, Series 2, No. 62.

    ERIC Educational Resources Information Center

    Neman, Ronald S.; And Others

    The study represents an extension of previous research involving the development of scales for the five-card, orally administered, and tape-recorded version of the Thematic Apperception Test(TAT). Scale development is documented and national norms are presented based on a national probability sample of 1,398 youths administered the Cycle III test…

  7. The Drosophila dysfusion basic helix-loop-helix (bHLH)-PAS gene controls tracheal fusion and levels of the trachealess bHLH-PAS protein.

    PubMed

    Jiang, Lan; Crews, Stephen T

    2003-08-01

    The development of the mature insect trachea requires a complex series of cellular events, including tracheal cell specification, cell migration, tubule branching, and tubule fusion. Here we describe the identification of the Drosophila melanogaster dysfusion gene, which encodes a novel basic helix-loop-helix (bHLH)-PAS protein conserved between Caenorhabditis elegans, insects, and humans, and controls tracheal fusion events. The Dysfusion protein functions as a heterodimer with the Tango bHLH-PAS protein in vivo to form a putative DNA-binding complex. The dysfusion gene is expressed in a variety of embryonic cell types, including tracheal-fusion, leading-edge, foregut atrium cells, nervous system, hindgut, and anal pad cells. RNAi experiments indicate that dysfusion is required for dorsal branch, lateral trunk, and ganglionic branch fusion but not for fusion of the dorsal trunk. The escargot gene, which is also expressed in fusion cells and is required for tracheal fusion, precedes dysfusion expression. Analysis of escargot mutants indicates a complex pattern of dysfusion regulation, such that dysfusion expression is dependent on escargot in the dorsal and ganglionic branches but not the dorsal trunk. Early in tracheal development, the Trachealess bHLH-PAS protein is present at uniformly high levels in all tracheal cells, but since the levels of Dysfusion rise in wild-type fusion cells, the levels of Trachealess in fusion cells decline. The downregulation of Trachealess is dependent on dysfusion function. These results suggest the possibility that competitive interactions between basic helix-loop-helix-PAS proteins (Dysfusion, Trachealess, and possibly Similar) may be important for the proper development of the trachea. PMID:12897136

  8. Assessing Early Literacy Skills with the Mountain Shadows Phonemic Awareness Scale (MS-PAS)

    ERIC Educational Resources Information Center

    Watkins, Marley W.; Edwards, Vicki A.

    2004-01-01

    Considerable evidence suggests that phonemic awareness is associated with the development of skilled reading. Consequently, it is recommended that beginning readers be assessed to ensure adequate development of phonemic awareness skills. When choosing an assessment method, reliability and validity, ease of administration and scoring, and…

  9. Faux pas detection and intentional action in Asperger Syndrome. A replication on a French sample.

    PubMed

    Zalla, Tiziana; Sav, Anca-Maria; Stopin, Astrid; Ahade, Sabrina; Leboyer, Marion

    2009-02-01

    In the present study, we investigated mind reading abilities in a group of adults with Asperger Syndrome (AS) by using the faux pas task, an advanced test of theory of mind (Baron-Cohen et al. (1999). Journal of Autism and Developmental Disorders, 29, 407-418). The faux pas is a particular case of a non-intentional action reflecting an involuntary socially inappropriate behavior. Here, individuals with AS over-detected faux pas stories, failed to provide correct justifications of the speaker's behavior and were unaware of the mistaken belief and of the resulting emotional impact, whereas they appeared to be responsive to social rule violations. We hypothesized that because of an impaired theory-of-mind, individuals with AS may develop compensatory cognitive strategies based on overlearned abstract knowledge about normative rules. PMID:18726150

  10. Space Data Systems Applications in the iPAS Pathfinder Laboratory

    NASA Technical Reports Server (NTRS)

    Rich, Tom

    2013-01-01

    The iPAS is an integrated hardware/software test and evaluation environment, in support of current and future spacecraft development The iPAS has two main elements. A common avionics, hardware, and software architecture that can be applied over various missions. A common testbed framework that supports integrated hardware/software testing for a variety of applications. The iPAS includes the following (non-flight qualified) components: Core Flight Software (from GSFC). Commercially available Proton and S950 Flight Computer boards. Power and propulsion systems based on representative flight hardware. A realistic flight deck based on the Multi-Purpose Crew Vehicle (MPCV), including realistic flight controls and displays. A Space Data System based on CCSDS protocols.

  11. Ultrastructural evidence of Tropheryma whippelii in PAS-negative granulomatous lymph nodes.

    PubMed

    Finzi, Giovanna; Franzi, Francesca; Sessa, Fausto; Mastaglio, Claudio; Capella, Carlo

    2007-01-01

    The presence of Tropheryma whippelii was demonstrated in the PAS-negative mesenteric granulomatous lymph nodes of a patient affected by Whipple disease. Ultrastructurally a few bacteria, enclosed by a membrane characteristic of Tropheryma whippelii, were found in the extracellular spaces and remnants of bacteria were found in the phagocytic vacuoles of macrophages. The scarce number of bacilli, probably due to the fact that the disease was at an initial phase, could explain the absence of PAS positivity. This case confirms the role of the electron microscopy in the diagnosis of Whipple disease, especially for extra-intestinal lesions and at the initial phase of the disease, when the characteristic PAS-positive macrophages can be absent. PMID:17613996

  12. PAS/LOV proteins: A proposed new class of plant blue light receptor.

    PubMed

    Ogura, Yasunobu; Tokutomi, Satoru; Wada, Masamitsu; Kiyosue, Tomohiro

    2008-11-01

    The light, oxygen or voltage (LOV) domain belongs to the Per-ARNT-Sim (PAS) superfamily of domains, and functions with the flavin chromophore as a module for sensing blue light in plants and fungi. The Arabidopsis thaliana PAS/LOV proteins (PLPs), of unknown function, possess an N-terminal PAS domain and a C-terminal LOV domain. Our recent analysis using yeast two-hybrid and Escherichia coli protein production systems reveals that the interactions of Arabidopsis PLPs with several proteins diminish under blue light illumination and that the PLP LOV domain may bind to a flavin chromophore. These results suggest that PLP functions as a blue light receptor. Homologs of PLP exist in rice, tomato and moss. The LOV domains of these PLP homologs form a distinct group in phylogenetic analysis. These facts suggest that PLP belongs to a new class of plant blue light receptor. PMID:19704421

  13. Scales

    MedlinePlus

    Scales are a visible peeling or flaking of outer skin layers. These layers are called the stratum ... Scales may be caused by dry skin, certain inflammatory skin conditions, or infections. Eczema , ringworm , and psoriasis ...

  14. Pituitary Adenoma With Paraganglioma/Pheochromocytoma (3PAs) and Succinate Dehydrogenase Defects in Humans and Mice

    PubMed Central

    Xekouki, Paraskevi; Szarek, Eva; Bullova, Petra; Giubellino, Alessio; Quezado, Martha; Mastroyannis, Spyridon A.; Mastorakos, Panagiotis; Wassif, Christopher A.; Raygada, Margarita; Rentia, Nadia; Dye, Louis; Cougnoux, Antony; Koziol, Deloris; Sierra, Maria de La Luz; Lyssikatos, Charalampos; Belyavskaya, Elena; Malchoff, Carl; Moline, Jessica; Eng, Charis; Maher, Louis James; Pacak, Karel; Lodish, Maya

    2015-01-01

    Context: Germline mutations in genes coding succinate dehydrogenase (SDH) subunits A, B, C, and D have been identified in familial paragangliomas (PGLs)/pheochromocytomas (PHEOs) and other tumors. We described a GH-secreting pituitary adenoma (PA) caused by SDHD mutation in a patient with familial PGLs. Additional patients with PAs and SDHx defects have since been reported. Design: We studied 168 patients with unselected sporadic PA and with the association of PAs, PGLs, and/or pheochromocytomas, a condition we named the 3P association (3PAs) for SDHx germline mutations. We also studied the pituitary gland and hormonal profile of Sdhb+/− mice and their wild-type littermates at different ages. Results: No SDHx mutations were detected among sporadic PA, whereas three of four familial cases were positive for a mutation (75%). Most of the SDHx-deficient PAs were either prolactinomas or somatotropinomas. Pituitaries of Sdhb+/− mice older than 12 months had an increased number mainly of prolactin-secreting cells and several ultrastructural abnormalities such as intranuclear inclusions, altered chromatin nuclear pattern, and abnormal mitochondria. Igf-1 levels of mutant mice tended to be higher across age groups, whereas Prl and Gh levels varied according to age and sex. Conclusion: The present study confirms the existence of a new association that we termed 3PAs. It is due mostly to germline SDHx defects, although sporadic cases of 3PAs without SDHx defects also exist. Using Sdhb+/− mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to PA formation. PMID:25695889

  15. J-PAS: The Javalambre-Physics of the Accelerating Universe Astrophysical Survey

    NASA Astrophysics Data System (ADS)

    Dupke, Renato A.; Benitez, Narciso; Moles, Mariano; Sodre, Laerte; Irwin, Jimmy; J-PAS Collaboration

    2016-01-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is a narrow band, very wide field Cosmological Survey to be carried out from the Javalambre Astrophysical Observatory in Spain with a dedicated 2.5m telescope and a 4.7deg^2 camera with 1.2Gpix. Starting in 2016, J-PAS will observe 8600 deg^2 of the Northern Sky and measure 0.003(1+z) precision photometric redshifts for nearly 1E08 LRG and ELG galaxies plus several million QSOs, sampling an effective volume of ~14 Gpc^3 up to z = 1.3. J-PAS will also detect and measure the mass of more than a hundred thousand galaxy clusters, setting constrains on Dark Energy which rival those obtained from BAO measurements.The key to the J-PAS potential is its innovative approach the combination of 54 145°A filters, placed 100°A apart, and a multi-degree field of view (FOV) which makes it a powerful "redshift machine", with the survey speed of a 4000 multiplexing low resolution spectrograph, but many times cheaper and much faster to build. Moreover, since the J-PAS camera is equivalent to a very large, 4.7deg^2 "IFU", it will produce a time-resolved, 3D image of the Northern Sky with a very wide range of Astrophysical applications in Galaxy Evolution, the nearby Universe and the study of resolved stellar populations. J-PAS will have a lasting legacy value in many areas of Astrophysics, serving as a fundamental dataset for future Cosmological projects.Here, we present the overall description, status and scientific potential of the survey.

  16. J-PAS: The Javalambre-Physics of the Accelerating Universe Astrophysical Survey

    NASA Astrophysics Data System (ADS)

    Dupke, Renato a.; Benitez, Narciso; Moles, Mariano; Sodre, Laerte; J-PAS Collaboration

    2015-08-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is a narrow band, very wide field Cosmological Survey to be carried out from the Javalambre Astrophysical Observatory in Spain with a dedicated 2.5m telescope and a 4.7deg^2 camera with 1.2Gpix. Starting in 2016, J-PAS will observe 8600 deg^2 of the Northern Sky and measure 0.003(1+z) precision photometric redshifts for nearly 1E08 LRG and ELG galaxies plus several million QSOs, sampling an effective volume of ~14 Gpc^3 up to z = 1.3. J-PAS will also detect and measure the mass of more than a hundred thousand galaxy clusters, setting constrains on Dark Energy which rival those obtained from BAO measurements.The key to the J-PAS potential is its innovative approach the combination of 54 145°A filters, placed 100°A apart, and a multi-degree field of view (FOV) which makes it a powerful “redshift machine”, with the survey speed of a 4000 multiplexing low resolution spectrograph, but many times cheaper and much faster to build. Moreover, since the J-PAS camera is equivalent to a very large, 4.7deg^2 “IFU”, it will produce a time-resolved, 3D image of the Northern Sky with a very wide range of Astrophysical applications in Galaxy Evolution, the nearby Universe and the study of resolved stellar populations. J-PAS will have a lasting legacy value in many areas of Astrophysics, serving as a fundamental dataset for future Cosmological projects.Here, we present the overall description, status and scientific potential of the survey.

  17. Digital radiography using amorphous selenium: photoconductively activated switch (PAS) readout system.

    PubMed

    Reznik, Nikita; Komljenovic, Philip T; Germann, Stephen; Rowlands, John A

    2008-03-01

    A new amorphous selenium (a-Se) digital radiography detector is introduced. The proposed detector generates a charge image in the a-Se layer in a conventional manner, which is stored on electrode pixels at the surface of the a-Se layer. A novel method, called photoconductively activated switch (PAS), is used to read out the latent x-ray charge image. The PAS readout method uses lateral photoconduction at the a-Se surface which is a revolutionary modification of the bulk photoinduced discharge (PID) methods. The PAS method addresses and eliminates the fundamental weaknesses of the PID methods--long readout times and high readout noise--while maintaining the structural simplicity and high resolution for which PID optical readout systems are noted. The photoconduction properties of the a-Se surface were investigated and the geometrical design for the electrode pixels for a PAS radiography system was determined. This design was implemented in a single pixel PAS evaluation system. The results show that the PAS x-ray induced output charge signal was reproducible and depended linearly on the x-ray exposure in the diagnostic exposure range. Furthermore, the readout was reasonably rapid (10 ms for pixel discharge). The proposed detector allows readout of half a pixel row at a time (odd pixels followed by even pixels), thus permitting the readout of a complete image in 30 s for a 40 cm x 40 cm detector with the potential of reducing that time by using greater readout light intensity. This demonstrates that a-Se based x-ray detectors using photoconductively activated switches could form a basis for a practical integrated digital radiography system. PMID:18404939

  18. Digital radiography using amorphous selenium: Photoconductively activated switch (PAS) readout system

    SciTech Connect

    Reznik, Nikita; Komljenovic, Philip T.; Germann, Stephen; Rowlands, John A.

    2008-03-15

    A new amorphous selenium (a-Se) digital radiography detector is introduced. The proposed detector generates a charge image in the a-Se layer in a conventional manner, which is stored on electrode pixels at the surface of the a-Se layer. A novel method, called photoconductively activated switch (PAS), is used to read out the latent x-ray charge image. The PAS readout method uses lateral photoconduction at the a-Se surface which is a revolutionary modification of the bulk photoinduced discharge (PID) methods. The PAS method addresses and eliminates the fundamental weaknesses of the PID methods--long readout times and high readout noise--while maintaining the structural simplicity and high resolution for which PID optical readout systems are noted. The photoconduction properties of the a-Se surface were investigated and the geometrical design for the electrode pixels for a PAS radiography system was determined. This design was implemented in a single pixel PAS evaluation system. The results show that the PAS x-ray induced output charge signal was reproducible and depended linearly on the x-ray exposure in the diagnostic exposure range. Furthermore, the readout was reasonably rapid (10 ms for pixel discharge). The proposed detector allows readout of half a pixel row at a time (odd pixels followed by even pixels), thus permitting the readout of a complete image in 30 s for a 40 cmx40 cm detector with the potential of reducing that time by using greater readout light intensity. This demonstrates that a-Se based x-ray detectors using photoconductively activated switches could form a basis for a practical integrated digital radiography system.

  19. Psychometric Properties and Norms of the German ABC-Community and PAS-ADD Checklist

    ERIC Educational Resources Information Center

    Zeilinger, Elisabeth L.; Weber, Germain; Haveman, Meindert J.

    2011-01-01

    Aim: The aim of the present study was to standardize and generate psychometric evidence of the German language versions of two well-established English language mental health instruments: the "Aberrant Behavior Checklist-Community" (ABC-C) and the "Psychiatric Assessment Schedule for Adults with Developmental Disabilities" (PAS-ADD) Checklist. New…

  20. Crystal structure of the PAS domain of the hEAG potassium channel.

    PubMed

    Tang, Xue; Shao, Juan; Qin, Xiaohong

    2016-08-01

    KCNH voltage-gated potassium channels play critical roles in regulating cellular functions. The channel is composed of four subunits, each of which contains six transmembrane helices forming the central pore. The cytoplasmic parts of the subunits present a Per-Arnt-Sim (PAS) domain at the N-terminus and a cyclic nucleotide-binding homology domain at the C-terminus. PAS domains are conserved from prokaryotes to eukaryotes and are involved in sensing signals and cellular responses. To better understand the functional roles of PAS domains in KCNH channels, the structure of this domain from the human ether-à-go-go channel (hEAG channel) was determined. By comparing it with the structures of the Homo sapiens EAG-related gene (hERG) channel and the Drosophila EAG-like K(+) (dELK) channel and analyzing the structural features of the hEAG channel, it was identified that a hydrophobic patch on the β-sheet may mediate interaction between the PAS domain and other regions of the channel to regulate its functions. PMID:27487920

  1. Crystal structure of the PAS domain of the hEAG potassium channel

    PubMed Central

    Tang, Xue; Shao, Juan; Qin, Xiaohong

    2016-01-01

    KCNH voltage-gated potassium channels play critical roles in regulating cellular functions. The channel is composed of four subunits, each of which contains six transmembrane helices forming the central pore. The cytoplasmic parts of the subunits present a Per–Arnt–Sim (PAS) domain at the N-terminus and a cyclic nucleotide-binding homology domain at the C-terminus. PAS domains are conserved from prokaryotes to eukaryotes and are involved in sensing signals and cellular responses. To better understand the functional roles of PAS domains in KCNH channels, the structure of this domain from the human ether-à-go-go channel (hEAG channel) was determined. By comparing it with the structures of the Homo sapiens EAG-related gene (hERG) channel and the Drosophila EAG-like K+ (dELK) channel and analyzing the structural features of the hEAG channel, it was identified that a hydrophobic patch on the β-sheet may mediate interaction between the PAS domain and other regions of the channel to regulate its functions. PMID:27487920

  2. 32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy...

  3. 32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false When to give Privacy Act Statements (PAS). 806b... ADMINISTRATION PRIVACY ACT PROGRAM Collecting Personal Information § 806b.11 When to give Privacy Act Statements... information. Give a copy of the Privacy Act Statement if asked. Do not ask the person to sign the Privacy...

  4. Searching for planetary nebulae at the Galactic halo via J-PAS

    NASA Astrophysics Data System (ADS)

    Gonçalves, Denise R.; Aparício-Villegas, T.; Akras, S.; Cortesi, A.; Borges-Fernandes, M.; Daflon, S.; Pereira, C. B.; Lorenz-Martins, S.; Marcolino, W.; Kanaan, A.; Viironen, K.; de Oliveira, C. Mendes; Molino, A.; Ederoclite, A.

    2016-08-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is a narrow-band imaging, very wide field cosmological survey. It will last 5 years and will observe 8500 sq. deg. of the sky. There will be 54 contiguous narrow-band filters of 145Å FWHM, from 3,500 to 10,000Å. Two broad-band filters will be added at the extremes, UV and IR, plus the 3-g, r, and i- SDSS filters. Thus, J-PAS can be an important tool to search for new planetary nebulae (PNe) at the halo, increasing their numbers, because only 14 of them have been convincingly identified in the literature. Halo PNe are able to reveal precious information for the study of stellar evolution and the early chemical conditions of the Galaxy. The characteristic low continuum and intense emission lines of PNe make them good objects to be searched by J-PAS. Though covering a significantly smaller sky area, data from the ALHAMBRA survey were used to test our J-PAS strategy to search for PNe. Our first results are shown in this contribution.

  5. Test report for PAS-1 cask certification for shipping payload B

    SciTech Connect

    MERCADO, J.E.

    1998-10-13

    This test report documents the successful inspection and testing to certify two NuPac PAS-1 casks in accordance with US Department of Energy Certificate of Compliance (CoC) USA/9184/B(U). The primary and secondary containment vessels of each cask met the acceptance criteria defined in the CoC and the test plan.

  6. J-PAS: The Javalambre-Physics of the Accelerated Universe Astrophysical Survey

    NASA Astrophysics Data System (ADS)

    Benítez, N.; Dupke, R.; Moles, M.; Sodré, L.; Cenarro, A. J.; Marín Franch, A.; Taylor, K.; Cristóbal, D.; Fernández-Soto, A.; Mendes de Oliveira, C.; Cepa-Nogué, J.; Abramo, L. R.; Alcaniz, J. S.; Overzier, R.; Hernández-Monteagudo, C.; Alfaro, E. J.; Kanaan, A.; Carvano, M.; Reis, R. R. R.; J-PAS Collaboration

    2015-05-01

    J-PAS is a Spanish-Brazilian 8500 deg^2 Cosmological Survey which will be carried out from the Javalambre Observatory with a purpose-built, dedicated 2.5 m telescope and a 4.7 deg^2 camera with 1.2 Gpix. Starting in 2015, J-PAS will use 59 filters to measure high precision 0.003(1+z) photometric redshifts for 90M galaxies plus several million QSOs, about 50 times more than the largest current spectroscopic survey, sampling an effective volume of ˜ 14 Gpc^3 up to z=1.3. J-PAS will not only be first radial BAO experiment to reach Stage IV; it will also detect and measure the mass of 7× 10^5 galaxy clusters and groups, setting constrains on Dark Energy which rival those obtained from BAO measurements. The combination of a set of 145 Å NB filters, placed 100 Å apart, and a multi-degree field of view is a powerful ``redshift machine'', equivalent to a 4000 multiplexing spectrograph, but many times cheaper to build. The J-PAS camera is equivalent to a very large, 4.7 deg^2 ``IFU'', which will produce a time-resolved, 3D image of the Northern Sky with a very wide range of scientific applications in Galaxy Evolution, Stellar Physics and the Solar System.

  7. Peer Relations and the Understanding of Faux Pas: Longitudinal Evidence for Bidirectional Associations

    ERIC Educational Resources Information Center

    Banerjee, Robin; Watling, Dawn; Caputi, Marcella

    2011-01-01

    Research connecting children's understanding of mental states to their peer relations at school remains scarce. Previous work by the authors demonstrated that children's understanding of mental states in the context of a faux pas--a social blunder involving unintentional insult--is associated with concurrent peer rejection. The present report…

  8. Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS).

    PubMed

    Slichter, Sherrill J; Corson, Jill; Jones, Mary Kay; Christoffel, Todd; Pellham, Esther; Bailey, S Lawrence; Bolgiano, Doug

    2014-01-01

    To evaluate the poststorage viability of apheresis platelets stored for up to 18 days in 80% platelet additive solution (PAS)/20% plasma, 117 healthy subjects donated platelets using the Haemonetics MCS+, COBE Spectra (Spectra), or Trima Accel (Trima) systems. Control platelets from the same subjects were compared with their stored test PAS platelets by radiolabeling their stored and control platelets with either (51)chromium or (111)indium. Trima platelets met Food and Drug Administration poststorage platelet viability criteria for only 7 days vs almost 13 days for Haemonetics platelets; ie, platelet recoveries after these storage times averaged 44 ± 3% vs 49 ± 3% and survivals were 5.4 ± 0.3 vs 4.6 ± 0.3 days, respectively. The differences in storage duration are likely related to both the collection system and the storage bag. The Spectra and Trima platelets were hyperconcentrated during collection, and PAS was added, whereas the Haemonetics platelets were elutriated with PAS, which may have resulted in less collection injury. When Spectra and Trima platelets were stored in Haemonetics' bags, poststorage viability was significantly improved. Platelet viability is better maintained in vitro than in vivo, allowing substantial increases in platelet storage times. However, implementation will require resolution of potential bacterial overgrowth during storage. PMID:24258816

  9. Using the Social, Attitudinal, Familial, and Environmental (S.A.F.E.) Acculturation Stress Scale to Assess the Adjustment Needs of Hispanic College Students.

    ERIC Educational Resources Information Center

    Fuertes, Jairo N.; Westbrook, Franklin D.

    1996-01-01

    Reexamined the validity and reliability of the 24-item S.A.F.E. scale and found it to be a reliable measure of Hispanics' acculturation stress. Also studied the effect of generational status, gender, and socioeconomic status on the levels of acculturation stress experienced by this sample. (RJM)

  10. Child Adjustment and Parent Efficacy Scale-Developmental Disability (CAPES-DD): First psychometric evaluation of a new child and parenting assessment tool for children with a developmental disability.

    PubMed

    Emser, Theresa S; Mazzucchelli, Trevor G; Christiansen, Hanna; Sanders, Matthew R

    2016-01-01

    This study examined the psychometric properties of the Child Adjustment and Parent Efficacy Scale-Developmental Disability (CAPES-DD), a brief inventory for assessing emotional and behavioral problems of children with developmental disabilities aged 2- to 16-years, as well as caregivers' self-efficacy in managing these problems. A sample of 636 parents participated in the study. Children's ages ranged from 2 to 15. Exploratory and confirmatory factor analyses supported a 21-item, three-factor model of CAPES-DD child adjustment with 13 items describing behavioral (10 items) and emotional (3 items) problems and 8 items describing prosocial behavior. Three additional items were included due to their clinical usefulness and contributed to a Total Problem Score. Factor analyses also supported a 16-item, one factor model of CAPES-DD self-efficacy. Psychometric evaluation of the CAPES-DD revealed scales had satisfactory to very good internal consistency, as well as very good convergent and predictive validity. The instrument is to be in the public domain and free for practitioners and researchers to use. Potential uses of the measure and implications for future validation studies are discussed. PMID:26921524

  11. Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

    ERIC Educational Resources Information Center

    Thiébaut, Flora I.; White, Sarah J.; Walsh, Annabel; Klargaard, Solja K.; Wu, Hsuan-Chen; Rees, Geraint; Burgess, Paul W.

    2016-01-01

    43 typically-developed adults and 35 adults with ASD performed a cartoon faux pas test. Adults with ASD apparently over-detected faux pas despite good comprehension abilities, and were generally slower at responding. Signal detection analysis demonstrated that the ASD participants had significantly greater difficulty detecting whether a cartoon…

  12. Accurate PSF-matched photometry for the J-PAS survey

    NASA Astrophysics Data System (ADS)

    Jimenez-Teja, Yolanda; Benitez, Txitxo; Dupke, Renato a.

    2015-08-01

    The Javalambre-PAU Astrophysical Survey (J-PAS) is expected to map 8,600 squared-degrees of the sky using 54 narrow and 5 broad band filters. Carried out by a Spanish-Brazilian consortium, the main goal of this survey is to measure Baryon Acoustic Oscillations (BAOs) with photometric redshifts. The expectation is measuring these photometric redshifts with a precision of dz/(1 + z) ~ 0.003 for 100 million galaxies and a few millions of quasars, and reaching an accuracy of dz/(1 + z) ~ 0.01 for other 300 million galaxies. With these numbers, it will be possible to determine w in the Dark Energy (DE) equation of state with an accuracy of < 4%. To achieve such precision and measure the radial BAOs, not only an advanced technical setup but also special data processing tools are required. These tools must be accurate as well as suitable to be implemented in fully automated and computationally efficient algorithms.The factor that most influences the photometric redshift precision is the quality of the photometry. For that reason we have developed a new technique based on the Chebyshev-Fourier bases (CHEFs, Jiménez-Teja & Benítez 2012, ApJ, 745, 150) to obtain a highly precise multicolor photometry without PSF consideration, thus saving a considerable amount of time and circumventing severe problems such as the PSF variability across the images. The CHEFs are a set of mathematical orthonormal bases with different scale and resolution levels, originally designed to fit the surface light distribution of galaxies. They have proved to be able to model any kind of morphology, including spirals, highly elliptical, or irregular galaxies, including isophotal twists and fine substructure. They also fit high signal-to-noise images, lensing arcs and stars with great accuracy. We can calculate optimal, unbiased, total magnitudes directly through these CHEFs models and, thus, colors without needing the PSF.We compare our photometry with widely-used codes such as SExtractor (Bertin

  13. Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

    PubMed

    Thiébaut, Flora I; White, Sarah J; Walsh, Annabel; Klargaard, Solja K; Wu, Hsuan-Chen; Rees, Geraint; Burgess, Paul W

    2016-01-01

    43 typically-developed adults and 35 adults with ASD performed a cartoon faux pas test. Adults with ASD apparently over-detected faux pas despite good comprehension abilities, and were generally slower at responding. Signal detection analysis demonstrated that the ASD participants had significantly greater difficulty detecting whether a cartoon depicted a faux pas and showed a liberal response bias. Test item analysis demonstrated that the ASD group were not in agreement with a reference control group (n = 69) about which non-faux pas items were most difficult. These results suggest that the participants with ASD had a primary problem with faux pas detection, but that there is another factor at work, possibly compensatory, that relates to their choice of a liberal response criterion. PMID:26276266

  14. Searching for planetary nebulae at the Galactic halo via J-PAS and J-PLUS

    NASA Astrophysics Data System (ADS)

    Goncalves, Denise R.; Aparício-Villegas, Teresa; Akras, Stavros; Borges Fernandes, Marcelo; J-PAS Collaboration

    2015-08-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is a narrow-band imaging, very wide field cosmological survey to be carried out from a dedicated 2.5m telescope and a 4.7 sq.deg camera with 1.2Gpix. It will last 5 years and will observe 8500 sq.deg of Northern sky to a 5-σ magnitude depth for point sources, equivalent to i ~23.3 over an aperture of 2 arcsec2. The J-PAS filter system consists of 54 contiguous narrow band filters of 145-Å FWHM, from 3,500 to 10,000Å. Two broad-band filters will be added at the extremes, UV and IR, plus 3 SDSS g, r, and i filters. The Javalambre Photometric Local Universe Survye (J-PLUS) will be an auxiliary survey ofJ-PAS (mainly for calibration) with a dedicated 0.80m telescope. J-PLUS comprises 12 filters, including g, r, i and z SDSS ones. Though about 2,500 planetary nebulae (PNe, confirmed spectroscopically) are known in the Galaxy, only 14 objects have been convincingly identified as halo PNe. They were classified as such from their location, kinematics and chemistry. Halo PNe are able to reveal precious information for the study of low- and intermediate-mass star evolution and the early chemical conditions of the Galaxy. The characteristic low continuum and intense line emissions of PNe make them good objects to be searched by J-PAS, and even by J-PLUS. For instance, the halo PNe BoBn 1, DdDm 1 and PS 1, located somewhere between 11 and 24 kpc from the Sun, have B magnitudes of 16, 14 and 13.4, respectively. Such values are easily encompassed by J-PAS/J-PLUS, given the typical limit magnitude of the survey. Though covering a significantly smaller sky area, data from the ALHAMBRA survey were used to test our J-PAS/J-PLUS strategy to search for PNe. Our first results will be shown in this poster.

  15. Convective adjustment in baroclinic atmospheres

    NASA Technical Reports Server (NTRS)

    Emanuel, Kerry A.

    1986-01-01

    Local convection in planetary atmospheres is generally considered to result from the action of gravity on small regions of anomalous density. That in rotating baroclinic fluids the total potential energy for small scale convection contains a centrifugal as well as a gravitational contribution is shown. Convective adjustment in such an atmosphere results in the establishment of near adiabatic lapse rates of temperature along suitably defined surfaces of constant angular momentum, rather than in the vertical. This leads in general to sub-adiabatic vertical lapse rates. That such an adjustment actually occurs in the earth's atmosphere is shown by example and the magnitude of the effect for several other planetary atmospheres is estimated.

  16. Scale

    ERIC Educational Resources Information Center

    Schaffhauser, Dian

    2009-01-01

    The common approach to scaling, according to Christopher Dede, a professor of learning technologies at the Harvard Graduate School of Education, is to jump in and say, "Let's go out and find more money, recruit more participants, hire more people. Let's just keep doing the same thing, bigger and bigger." That, he observes, "tends to fail, and fail…

  17. Queer paradox/paradoxical queer: Anne Garréta's Pas un jour (2002).

    PubMed

    Cairns, Lucille

    2007-01-01

    This paper shows how Anne Garréta's Pas un jour (2002) is a decidedly queer text, in both the new and the old sense of that contested epithet. I examine three interrelated concerns central to Pas un jour. First, I analyze Garréta's mediation of desire in general: her own experiences of it; modalities thereof which subvert more 'normative' models of lesbianism; and her convergences with other gay, but male writers and theorists of desire such as Guy Hocquenghem, Gilles Deleuze and Michel Foucault. Second, I interrogate Garréta's dichotomy between desire and friendship, and adumbrate contrasts with Foucauldian theory. Finally, I scrutinize the meaning and value attributed to the particular body of desire with which Garréta is most commonly associated-homosexuality- and their links with those of a contemporary gay male writer, Dominique Fernandez. PMID:17804371

  18. Extracytoplasmic pas-like domains are common in signal transduction proteins. ;

    SciTech Connect

    Chang, C.; Tesar, C.; Gu, M.; Babnigg, G.; Joachimiak, A.; Pokkuluri, P. R.; Szurmant, H.; Schiffer, M.

    2010-02-01

    We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain.

  19. Extracytoplasmic PAS-like domains are common in signal transduction proteins.

    SciTech Connect

    Schiffer, M.; Chang, C.; Tesar, C.; Gu, M.; Babnigg, G.; Joachimiak, A.; Pokkuluri, P. R.; Szurmant, H.; Biosciences Division; Scripps Research Inst.

    2010-02-01

    We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain.

  20. The roles of primary care PAs and NPs caring for older adults with diabetes.

    PubMed

    Everett, Christine M; Thorpe, Carolyn T; Palta, Mari; Carayon, Pascale; Gilchrist, Valerie J; Smith, Maureen A

    2014-04-01

    Electronic health record data linked with Medicare data from an academic physician group were used to propose a multidimensional characterization of PA and NP roles on panels of primary care patients with diabetes. Seven PA and NP roles were defined based on level of involvement, visits with complex patients, and delivery of chronic care. Findings suggest that PAs and NPs in primary care perform a variety of roles and frequently perform multiple roles within a clinic. PMID:24662258

  1. Practical Analysis of materials with depth varying compositions using FT-IR photoacoustic spectroscopy (PAS)

    SciTech Connect

    J.F. McClelland; R.W. Jones; Siquan Luo

    2004-09-30

    FT-IR photoacoustic spectroscopy (PAS) is discussed as a nondestructive method to probe the molecular composition of materials versus depth on the basis of the analysis of layers of experimentally controllable thickness, which are measured from the sample surface to depths of some tens of micrometers, depending on optical and thermal properties. Computational methods are described to process photoacoustic amplitude and phase spectra for both semi-quantitative and quantitative depth analyses. These methods are demonstrated on layered and gradient samples.

  2. A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues

    PubMed Central

    Mann, Thomas H.; Seth Childers, W.; Blair, Jimmy A.; Eckart, Michael R.; Shapiro, Lucy

    2016-01-01

    All cells must integrate sensory information to coordinate developmental events in space and time. The bacterium Caulobacter crescentus uses two-component phospho-signalling to regulate spatially distinct cell cycle events through the master regulator CtrA. Here, we report that CckA, the histidine kinase upstream of CtrA, employs a tandem-PAS domain sensor to integrate two distinct spatiotemporal signals. Using CckA reconstituted on liposomes, we show that one PAS domain modulates kinase activity in a CckA density-dependent manner, mimicking the stimulation of CckA kinase activity that occurs on its transition from diffuse to densely packed at the cell poles. The second PAS domain interacts with the asymmetrically partitioned second messenger cyclic-di-GMP, inhibiting kinase activity while stimulating phosphatase activity, consistent with the selective inactivation of CtrA in the incipient stalked cell compartment. The integration of these spatially and temporally regulated signalling events within a single signalling receptor enables robust orchestration of cell-type-specific gene regulation. PMID:27117914

  3. PAS/POLY-HAMP SIGNALING IN AER-2, A SOLUBLE HEME-BASED SENSOR

    PubMed Central

    Watts, Kylie J; Taylor, Barry L; Johnson, Mark S

    2011-01-01

    SUMMARY Poly-HAMP domains are widespread in bacterial chemoreceptors, but previous studies have focused on receptors with single HAMP domains. The Pseudomonas aeruginosa chemoreceptor, Aer-2, has an unusual domain architecture consisting of a PAS sensing domain sandwiched between three N-terminal and two C-terminal HAMP domains, followed by a conserved kinase control module. The structure of the N-terminal HAMP domains was recently solved, making Aer-2 the first protein with resolved poly-HAMP structure. The role of Aer-2 in P. aeruginosa is unclear, but here we show that Aer-2 can interact with the chemotaxis system of Escherichia coli to mediate repellent responses to oxygen, carbon monoxide and nitric oxide. Using this model system to investigate signaling and poly-HAMP function, we determined that the Aer-2 PAS domain binds penta-coordinated b-type heme and that reversible signaling requires four of the five HAMP domains. Deleting HAMP 2 and/or 3 resulted in a kinase-off phenotype, whereas deleting HAMP 4 and/or 5 resulted in a kinase-on phenotype. Overall, these data support a model in which ligand-bound Aer-2 PAS and HAMP 2 and 3 act together to relieve inhibition of the kinase control module by HAMP 4 and 5, resulting in the kinase-on state of the Aer-2 receptor. PMID:21255112

  4. Platelet storage in PAS-2 or autologous plasma: impact on functional parameters.

    PubMed

    Bunescu, A; Hild, M; Lundahl, J; Egberg, N

    2001-04-01

    Currently, several platelet additive solutions for long-term platelet storage have been introduced. The aim of this study was to compare the deterioration of functional status of platelets stored for up to 5 days in autologous plasma (AP) only, with platelet stored in PAS-2, a salt solution containing acetate, citrate and sodium chloride. Change in platelet adhesion, aggregation and activation was measured by flow cytometric technique. In addition, beta-Thromboglobulin (beta-TG), lactate and glucose were determined. After 5 days of storage, the expression of P-Selectin was significantly higher, the production of lactate and the consumption of glucose were significantly lower, in platelets stored in PAS-2 than in autologous plasma. No significant differences were detected on day 5 between the two groups with regard to fibrinogen, von Willebrand factor binding capacity, or to beta-TG release. It can be concluded that neither storage medium was consistently better for the parameters tested. However, it must be emphasized that platelets stored in autologous plasma exhibited less lesion, in terms of P-Selectin expression compared with platelets stored in PAS-2. PMID:11299027

  5. Laser diode bars based on strain-compensated AlGaPAs/GaAs heterostructures

    SciTech Connect

    Marmalyuk, Aleksandr A; Ladugin, M A; Yarotskaya, I V; Panarin, V A; Mikaelyan, G T

    2012-01-31

    Traditional (in the AlGaAs/GaAs system) and phosphorus-compensated (in the AlGaAs/AlGaPAs/GaAs system) laser heterostructures emitting at a wavelength of 850 nm are grown by MOVPE and studied. Laser diode bars are fabricated and their output characteristics are studied. The method used to grow heterolayers allowed us to control (minimise) mechanical stresses in the AlGaPAs/GaAs laser heterostructure, which made it possible to keep its curvature at the level of the initial curvature of the substrate. It is shown that the use of a compensated AlGaPAs/GaAs heterostructure improves the linear distribution of emitting elements in the near field of laser diode arrays and allows the power - current characteristic to retain its slope at high pump currents owing to a uniform contact of all emitting elements with the heat sink. The radius of curvature of the grown compensated heterostructures turns out to be smaller than that of traditional heterostructures.

  6. Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines.

    PubMed

    Galbiati, Federica; Pettinicchio, Angela; Dragani, Tommaso A; Manenti, Giacomo

    2006-12-01

    Four of the six genes constituting the mouse Pulmonary adenoma susceptibility 1 (Pas1) locus haplotype carry amino acid variants: Lrmp, Casc1, Ghiso, and Lmna-rs1. In vitro colony formation assay of human lung cancer cell lines A549 and NCI-H520 transfected with the allelic variants of the four genes revealed allele-specific modulations of colony numbers by Lmna-rs1 and Casc1, but not by Lrmp or Ghiso. In A549 and NCI-H520 cells, the A/J allele of Lmna-rs1 produced approximately 4- and approximately 2-fold, respectively, more transfectants than did the C57BL/6J allele, whereas the A/J allele of Casc1 produced approximately 6- and approximately 5-fold fewer transfectants, respectively, as compared to the C57BL/6J allele. Inhibition of clonogenicity by allelic forms of Pas1 candidate genes was not mediated by induction of apoptosis. These findings provide evidence that allelic variants of mouse Pas1 candidate genes differentially modulate growth of human cancer cells. PMID:16458428

  7. Principles of Ligand Binding within a Completely Buried Cavity in HIF2[alpha] PAS-B

    SciTech Connect

    Key, Jason; Scheuermann, Thomas H.; Anderson, Peter C.; Daggett, Valerie; Gardner, Kevin H.

    2010-04-19

    Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors responsible for the metazoan hypoxia response and promote tumor growth, metastasis, and resistance to cancer treatment. The C-terminal Per-ARNT-Sim (PAS) domain of HIF2{alpha} (HIF2{alpha} PAS-B) contains a preformed solvent-inaccessible cavity that binds artificial ligands that allosterically perturb the formation of the HIF heterodimer. To better understand how small molecules bind within this domain, we examined the structures and equilibrium and transition-state thermodynamics of HIF2{alpha} PAS-B with several artificial ligands using isothermal titration calorimetry, NMR exchange spectroscopy, and X-ray crystallography. Rapid association rates reveal that ligand binding is not dependent upon a slow conformational change in the protein to permit ligand access, despite the closed conformation observed in the NMR and crystal structures. Compensating enthalpic and entropic contributions to the thermodynamic barrier for ligand binding suggest a binding-competent transition state characterized by increased structural disorder. Finally, molecular dynamics simulations reveal conversion between open and closed conformations of the protein and pathways of ligand entry into the binding pocket.

  8. A Study on N2O Measurement Characteristics Using Photoacoustic Spectroscopy (PAS)

    PubMed Central

    Kang, Soyoung; Kim, Seoungjin; Kang, Seongmin; Lee, Jeongwoo; Cho, Chang-Sang; Sa, Jea-Hwan; Jeon, Eui-Chan

    2014-01-01

    N2O, which is emitted mainly from nitrogen decomposition via bacteria, livestock manure, agricultural fertilizer use, fossil fuel combustion and waste incineration, is classified as a substance that causes significant destruction of the ozone layer. The N2O measurement methods for these emission sources may be divided into chromatography, optical, and electrical current measurements. Chromatography has been widely utilized for analyzing N2O. However, up until now, few studies have been conducted on N2O using photoacoustic spectroscopy. Therefore, this study aimed to evaluate performance of photoacoustic spectroscopy in this regard based on laboratory and field test results. The repeatability of photoacoustic spectroscopy was measured at 1.12%, which is lower than the repeatability of 3.0% suggested by the ISO 1564 standard, so, it has shown an excellent repeatability. The detection limit was determined to be 0.025 ppm, and the response time was confirmed to be 3 min and 26 s. The results of comparison between these measurements and GC show that the latter has superior accuracy, but mobility and convenience are superior for PAS. On the contrary, GC has a continuous measurement limitation, but PAS makes it possible to conduct continuous measurements. Therefore, PAS can be extremely useful to confirm the characteristics of N2O emissions and to quantify their amount. PMID:25106022

  9. PAS/poly-HAMP signalling in Aer-2, a soluble haem-based sensor.

    PubMed

    Watts, Kylie J; Taylor, Barry L; Johnson, Mark S

    2011-02-01

    Poly-HAMP domains are widespread in bacterial chemoreceptors, but previous studies have focused on receptors with single HAMP domains. The Pseudomonas aeruginosa chemoreceptor, Aer-2, has an unusual domain architecture consisting of a PAS-sensing domain sandwiched between three N-terminal and two C-terminal HAMP domains, followed by a conserved kinase control module. The structure of the N-terminal HAMP domains was recently solved, making Aer-2 the first protein with resolved poly-HAMP structure. The role of Aer-2 in P. aeruginosa is unclear, but here we show that Aer-2 can interact with the chemotaxis system of Escherichia coli to mediate repellent responses to oxygen, carbon monoxide and nitric oxide. Using this model system to investigate signalling and poly-HAMP function, we determined that the Aer-2 PAS domain binds penta-co-ordinated b-type haem and that reversible signalling requires four of the five HAMP domains. Deleting HAMP 2 and/or 3 resulted in a kinase-off phenotype, whereas deleting HAMP 4 and/or 5 resulted in a kinase-on phenotype. Overall, these data support a model in which ligand-bound Aer-2 PAS and HAMP 2 and 3 act together to relieve inhibition of the kinase control module by HAMP 4 and 5, resulting in the kinase-on state of the Aer-2 receptor. PMID:21255112

  10. [Parental alienation syndrome (PAS): unknown in medical settings, endemic in courts].

    PubMed

    Pignotti, Maria Serenella

    2013-02-01

    A purposed syndrome of so-called parental alienation (PAS), unsupported by any evidence-based data, unknown in medical settings, unquoted in medical books, absent in DSM and ICD, never demonstrated by controlled studies published in high scientific level journals, is rampant in Courts where it can lead to loose parental custody. During a divorce trial, almost always the mothers and the children, become joint in a sort of folie au deux, in a denigration campaign of ex-husband/father. From a review on this issue it seems evident its theoretical roots lie on a theory that justify gender violence and children sexual abuse. The bias that both of them are layers and that he children have not autonomy block their possibility of any defence in front of a Court. In severe cases, PAS becomes a new and efficient tool of intra-familiar violence. The treatment of severe cases is to stop any contact between mother and children. The resort to PAS in Courts must be strongly rejected. PMID:23535957

  11. A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues.

    PubMed

    Mann, Thomas H; Seth Childers, W; Blair, Jimmy A; Eckart, Michael R; Shapiro, Lucy

    2016-01-01

    All cells must integrate sensory information to coordinate developmental events in space and time. The bacterium Caulobacter crescentus uses two-component phospho-signalling to regulate spatially distinct cell cycle events through the master regulator CtrA. Here, we report that CckA, the histidine kinase upstream of CtrA, employs a tandem-PAS domain sensor to integrate two distinct spatiotemporal signals. Using CckA reconstituted on liposomes, we show that one PAS domain modulates kinase activity in a CckA density-dependent manner, mimicking the stimulation of CckA kinase activity that occurs on its transition from diffuse to densely packed at the cell poles. The second PAS domain interacts with the asymmetrically partitioned second messenger cyclic-di-GMP, inhibiting kinase activity while stimulating phosphatase activity, consistent with the selective inactivation of CtrA in the incipient stalked cell compartment. The integration of these spatially and temporally regulated signalling events within a single signalling receptor enables robust orchestration of cell-type-specific gene regulation. PMID:27117914

  12. Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain.

    PubMed

    Harley, Carol A; Starek, Greg; Jones, David K; Fernandes, Andreia S; Robertson, Gail A; Morais-Cabral, João H

    2016-08-30

    The human human ether-à-go-go-related gene (hERG) potassium channel plays a critical role in the repolarization of the cardiac action potential. Changes in hERG channel function underlie long QT syndrome (LQTS) and are associated with cardiac arrhythmias and sudden death. A striking feature of this channel and KCNH channels in general is the presence of an N-terminal Per-Arnt-Sim (PAS) domain. In other proteins, PAS domains bind ligands and modulate effector domains. However, the PAS domains of KCNH channels are orphan receptors. We have uncovered a family of positive modulators of hERG that specifically bind to the PAS domain. We generated two single-chain variable fragments (scFvs) that recognize different epitopes on the PAS domain. Both antibodies increase the rate of deactivation but have different effects on channel activation and inactivation. Importantly, we show that both antibodies, on binding to the PAS domain, increase the total amount of current that permeates the channel during a ventricular action potential and significantly reduce the action potential duration recorded in human cardiomyocytes. Overall, these molecules constitute a previously unidentified class of positive modulators and establish that allosteric modulation of hERG channel function through ligand binding to the PAS domain can be attained. PMID:27516548

  13. Marital Adjustment Correlates in Young Couples.

    ERIC Educational Resources Information Center

    Haskell, Samuel D.

    The Locke-Wallace Marital Adjustment Scale was administered to 35 Caucasian, Protestant couples who were married an average of nine years, largely middle class, and lived in Knoxville, Tennessee. Significant correlates of marital adjustment were organized into groups of similar variables. Correlate groups that were the same for the husband and…

  14. Long-Term Large-Scale Bias-Adjusted Precipitation Estimates at High Spatial and Temporal Resolution Derived from the National Mosaic and Multi-Sensor QPE (NMQ/Q2) Precipitation Reanalysis over CONUS

    NASA Astrophysics Data System (ADS)

    Prat, O. P.; Nelson, B. R.; Stevens, S. E.; Seo, D. J.; Kim, B.

    2014-12-01

    The processing of radar-only precipitation via the reanalysis from the National Mosaic and Multi-Sensor Quantitative (NMQ/Q2) based on the WSR-88D Next-generation Radar (Nexrad) network over Continental United States (CONUS) is nearly completed for the period covering from 2000 to 2012. This important milestone constitutes a unique opportunity to study precipitation processes at a 1-km spatial resolution for a 5-min temporal resolution. However, in order to be suitable for hydrological, meteorological and climatological applications, the radar-only product needs to be bias-adjusted and merged with in-situ rain gauge information. Rain gauge networks such as the Hydrometeorological Automated Data System (HADS), the Automated Surface Observing Systems (ASOS), the Climate Reference Network (CRN), and the Global Historical Climatology Network - Daily (GHCN-D) are used to adjust for those biases and to merge with the radar only product to provide a multi-sensor estimate. The challenges related to incorporating non-homogeneous networks over a vast area and for a long-term record are enormous. Among the challenges we are facing are the difficulties incorporating differing resolution and quality surface measurements to adjust gridded estimates of precipitation. Another challenge is the type of adjustment technique. After assessing the bias and applying reduction or elimination techniques, we are investigating the kriging method and its variants such as simple kriging (SK), ordinary kriging (OK), and conditional bias-penalized Kriging (CBPK) among others. In addition we hope to generate estimates of uncertainty for the gridded estimate. In this work the methodology is presented as well as a comparison between the radar-only product and the final multi-sensor QPE product. The comparison is performed at various time scales from the sub-hourly, to annual. In addition, comparisons over the same period with a suite of lower resolution QPEs derived from ground based radar

  15. ADJUSTABLE DOUBLE PULSE GENERATOR

    DOEpatents

    Gratian, J.W.; Gratian, A.C.

    1961-08-01

    >A modulator pulse source having adjustable pulse width and adjustable pulse spacing is described. The generator consists of a cross coupled multivibrator having adjustable time constant circuitry in each leg, an adjustable differentiating circuit in the output of each leg, a mixing and rectifying circuit for combining the differentiated pulses and generating in its output a resultant sequence of negative pulses, and a final amplifying circuit for inverting and square-topping the pulses. (AEC)

  16. Adjustable sutures in children.

    PubMed

    Engel, J Mark; Guyton, David L; Hunter, David G

    2014-06-01

    Although adjustable sutures are considered a standard technique in adult strabismus surgery, most surgeons are hesitant to attempt the technique in children, who are believed to be unlikely to cooperate for postoperative assessment and adjustment. Interest in using adjustable sutures in pediatric patients has increased with the development of surgical techniques specific to infants and children. This workshop briefly reviews the literature supporting the use of adjustable sutures in children and presents the approaches currently used by three experienced strabismus surgeons. PMID:24924284

  17. Scales

    ScienceCinema

    Murray Gibson

    2010-01-08

    Musical scales involve notes that, sounded simultaneously (chords), sound good together. The result is the left brain meeting the right brain ? a Pythagorean interval of overlapping notes. This synergy would suggest less difference between the working of the right brain and the left brain than common wisdom would dictate. The pleasing sound of harmony comes when two notes share a common harmonic, meaning that their frequencies are in simple integer ratios, such as 3/2 (G/C) or 5/4 (E/C).

  18. Scales

    SciTech Connect

    Murray Gibson

    2007-04-27

    Musical scales involve notes that, sounded simultaneously (chords), sound good together. The result is the left brain meeting the right brain — a Pythagorean interval of overlapping notes. This synergy would suggest less difference between the working of the right brain and the left brain than common wisdom would dictate. The pleasing sound of harmony comes when two notes share a common harmonic, meaning that their frequencies are in simple integer ratios, such as 3/2 (G/C) or 5/4 (E/C).

  19. Retaining large and adjustable elastic strains of kilogram-scale Nb nanowires [Better Superconductor by Elastic Strain Engineering: Kilogram-scale Free-Standing Niobium Metal Composite with Large Retained Elastic Strains

    DOE PAGESBeta

    Hao, Shijie; Cui, Lishan; Wang, Hua; Jiang, Daqiang; Liu, Yinong; Yan, Jiaqiang; Ren, Yang; Han, Xiaodong; Brown, Dennis E.; Li, Ju

    2016-02-10

    Crystals held at ultrahigh elastic strains and stresses may exhibit exceptional physical and chemical properties. Individual metallic nanowires can sustain ultra-large elastic strains of 4-7%. However, retaining elastic strains of such magnitude in kilogram-scale nanowires is challenging. Here, we find that under active load, ~5.6% elastic strain can be achieved in Nb nanowires in a composite material. Moreover, large tensile (2.8%) and compressive (-2.4%) elastic strains can be retained in kilogram-scale Nb nanowires when the composite is unloaded to a free-standing condition. It is then demonstrated that the retained tensile elastic strains of Nb nanowires significantly increase their superconducting transitionmore » temperature and critical magnetic fields, corroborating ab initio calculations based on BCS theory. This free-standing nanocomposite design paradigm opens new avenues for retaining ultra-large elastic strains in great quantities of nanowires and elastic-strain-engineering at industrial scale.« less

  20. [Two cases of multi-drug-resistant pulmonary tuberculosis with para-aminosalicylic acid (PAS)-induced hypothyroidism].

    PubMed

    Mizutani, H; Horiba, M; Shindoh, J; Kimura, T; Son, M; Wakahara, K

    2001-10-01

    Two cases of multi-drug-resistant pulmonary tuberculosis with para-aminosalicylic acid (PAS)-induced hypothyroidism were reported. Case 1; a 73-year-old male, complaining of edema, was admitted to our hospital. He had been treated for his multi-drug-resistant pulmonary tuberculosis during the past 1 year with an antituberculous regimen consisting of ethambutol (EB), ethionamide (ETH) and PAS. A thyroid profile performed when he was admitted to our hospital showed several marked abnormalities: serum thyroid stimulating hormone (TSH) was elevated (69.4 microIU/ml: normal, 0.4-4.2 mIU/ml), free thyroxine level (T4) (0.01 ng/dl; normal, 0.70-1.60 ng/dl) and free triiodothyronine level (Ts) (0.60 pg/ml; normal, 2.3-4.1 pg/ml) were low. PAS was discontinued after he was admitted to our hospital, since PAS was believed to be the cause of the hypothyroidism. A thyroid profile that was repeated after the exclusion of PAS from treatment showed the following results: the TSH level was decreased (13.4 mIU/ml), the free T4 (0.93 ng/dl) were normal. During treatment with PAS, he had never received thyroid replacement therapy. Case 2; A 22-year-old female, complaining of hemosputum. She had been treated for her multi-drug-resistant pulmonary tuberculosis during the past 11 months with an antituberculous regimen consisting of EB, ETH and PAS. A thryoid profile performed when she was admitted to our hospital showed several marked abnormalities: elevated serum TSH (112.7 mIU/ml), and low T4 (2.0 micrograms/dl) and T3 (1.1 ng/ml). A thyroid profile that was repeated after the exclusion of PAS from treatment showed the following results: the TSH level was decreased (5.1 mIU/ml). Drug-induced hypothyroidism is an infrequent side effect of therapy with PAS, and only a few cases of PAS-induced hypothyroidism have been reported so far. In this report, we describe patients with hypothyroidism who were receiving therapy for multi-drug-resistant tuberculosis, tuberculosis namely, resistant

  1. The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation

    PubMed Central

    Ooms, Marcel; Cupac, Daniel; Abbink, Truus E. M.; Huthoff, Hendrik; Berkhout, Ben

    2007-01-01

    Initiation of reverse transcription of a retroviral RNA genome is strictly regulated. The tRNA primer binds to the primer binding site (PBS), and subsequent priming is triggered by the primer activation signal (PAS) that also pairs with the tRNA. We observed that in vitro reverse transcription initiation of the HIV-1 leader RNA varies in efficiency among 3′-end truncated transcripts, despite the presence of both PBS and PAS motifs. As the HIV-1 leader RNA can adopt two different foldings, we investigated if the conformational state of the transcripts did influence the efficiency of reverse transcription initiation. However, mutant transcripts that exclusively fold one or the other structure were similarly active, thereby excluding the possibility of regulation of reverse transcription initiation by the structure riboswitch. We next set out to determine the availability of the PAS element. This sequence motif enhances the efficiency of reverse transcription initiation, but its activity is regulated because the PAS motif is initially base paired within the wild-type template. We measured that the initiation efficiency on different templates correlates directly with accessibility of the PAS motif. Furthermore, changes in PAS are critical to facilitate a primer-switch to a new tRNA species, demonstrating the importance of this enhancer element. PMID:17308346

  2. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity

    SciTech Connect

    Marreilha dos Santos, A.P.; Lucas, Rui L.; Andrade, Vanda; Mateus, M. Luísa; Milatovic, Dejan; Aschner, Michael; Batoreu, M. Camila

    2012-02-01

    Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of the present study was to investigate the efficacy of ebselen (Ebs) and para-aminosalicylic acid (PAS) in attenuating the neurotoxic effects of Mn in an in vivo rat model. Exposure biomarkers, inflammatory and oxidative stress biomarkers, as well as behavioral parameters were evaluated. Co-treatment with Mn plus Ebs or Mn plus PAS caused a significant decrease in blood and brain Mn concentrations (compared to rats treated with Mn alone), concomitant with reduced brain E{sub 2} prostaglandin (PGE{sub 2}) and enhanced brain glutathione (GSH) levels, decreased serum prolactin (PRL) levels, and increased ambulation and rearing activities. Taken together, these results establish that both PAS and Ebs are efficacious in reducing Mn body burden, neuroinflammation, oxidative stress and locomotor activity impairments in a rat model of Mn-induced toxicity. -- Highlights: ► The manuscript is unique in its approach to the neurotoxicity of Mn. ► The manuscript incorporates molecular, cellular and functional (behavioral) analyses. ► Both PAS and Ebs are effective in restoring Mn behavioral function. ► Both PAS and Ebs are effective in reducing Mn-induced oxidative stress. ► Both PAS and Ebs led to a decrease in Mn-induced neuro-inflammation.

  3. Evaluation of existence region and formation time of particle accumulation structure (PAS) in half-zone liquid bridge

    NASA Astrophysics Data System (ADS)

    Gotoda, M.; Sano, T.; Kaneko, T.; Ueno, I.

    2015-03-01

    We focused on the particle accumulation structure (PAS) produced by the thermocapillary effect in a half-zone liquid bridge. Although models of the formation of the PAS have been previously proposed, they have not been experimentally verified. An assessment of the region in which the PAS exists is very subjective and often dependent on the observer, and this has necessitated the development of an objective and quantitative evaluation method. We therefore conducted a series of experiments to verify the physical model of the particle path lines in a rotating frame of reference using the fundamental frequency of the hydrothermal wave. We evaluated the intensity of the particle accumulation based on a modification of the "accumulation measure" proposed by Kuhlmann and Muldoon (Phys. Rev. E, 2012) to objectively and quantitatively determine the existence region of the SL-1 PAS. The results of the quantitative experiment revealed that the best aspect ratio (ratio of the height to radius) of the liquid bridge for the SL-1 PAS was about 0.64, and that the PAS formation time was nearly the same as the thermal diffusion time under the considered conditions (184 words, within 200 words).

  4. Burkholderia cepacia complex Phage-Antibiotic Synergy (PAS): antibiotics stimulate lytic phage activity.

    PubMed

    Kamal, Fatima; Dennis, Jonathan J

    2015-02-01

    The Burkholderia cepacia complex (Bcc) is a group of at least 18 species of Gram-negative opportunistic pathogens that can cause chronic lung infection in cystic fibrosis (CF) patients. Bcc organisms possess high levels of innate antimicrobial resistance, and alternative therapeutic strategies are urgently needed. One proposed alternative treatment is phage therapy, the therapeutic application of bacterial viruses (or bacteriophages). Recently, some phages have been observed to form larger plaques in the presence of sublethal concentrations of certain antibiotics; this effect has been termed phage-antibiotic synergy (PAS). Those reports suggest that some antibiotics stimulate increased production of phages under certain conditions. The aim of this study is to examine PAS in phages that infect Burkholderia cenocepacia strains C6433 and K56-2. Bcc phages KS12 and KS14 were tested for PAS, using 6 antibiotics representing 4 different drug classes. Of the antibiotics tested, the most pronounced effects were observed for meropenem, ciprofloxacin, and tetracycline. When grown with subinhibitory concentrations of these three antibiotics, cells developed a chain-like arrangement, an elongated morphology, and a clustered arrangement, respectively. When treated with progressively higher antibiotic concentrations, both the sizes of plaques and phage titers increased, up to a maximum. B. cenocepacia K56-2-infected Galleria mellonella larvae treated with phage KS12 and low-dose meropenem demonstrated increased survival over controls treated with KS12 or antibiotic alone. These results suggest that antibiotics can be combined with phages to stimulate increased phage production and/or activity and thus improve the efficacy of bacterial killing. PMID:25452284

  5. Jpcam: a 1.2 Gpixel Camera for the J-Pas Survey

    NASA Astrophysics Data System (ADS)

    Taylor, K.; Marín-Franch, A.; Laporte, R.; Santoro, F. G.; Marrara, L.; Cepa, J.; Cenarro, A. J.; Chueca, S.; Cristobal-Hornillos, D.; Ederoclite, A.; Gruel, N.; Moles, M.; Rueda, F.; Rueda, S.; Varela, J.; Yanes, A.; Benitez, N.; Dupke, R.; Fernández-Soto, A.; Jorden, P.; Lousberg, G.; Molino Benito, A.; Palmer, I.; Mendes de Oliveira, C.; Sodré, L.

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k 10 μm-pixel 16-channel detectors, to be deployed on a dedicated 2.55 m wide-field telescope at the OAJ (Observatorio Astrofísico de Javalambre) in Aragon, Spain. The camera is designed to perform a Baryon Acoustic Oscillations (BAO) survey of the northern sky. The J-PAS survey strategy will use 54 relatively narrow-band ( 13.8 nm) filters equi-spaced between 370 and 920 nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over 8000 square degrees of sky. The cryostat, detector mosaic and read electronics, is being supplied by e2v under contract to J-PAS while the mechanical structure, housing the shutter and filter assembly, is being designed and constructed by a Brazilian consortium led by INPE (Instituto Nacional de Pesquisas Espaciais). The cryostat is bridged to the telescope via a hexapod actuator system to maintain image quality across the field. Four sets of 14 filters are placed in the ambient environment, just above the dewar window but directly in line with the detectors, leading to a mosaic having 10 mm gaps between each CCD. The massive 500 mm aperture shutter is expected to be supplied by the Bonn-Shutter UG. We will present an overview of JPCam, from the filter configuration through to the CCD mosaic camera. A brief outline of the main J-PAS science projects will be included.

  6. Second Annual Maintenance, Inspection, and Test Report for PAS-1 Cask Certification for Shipping Payload B

    SciTech Connect

    KELLY, D.J.

    2000-10-09

    The Nuclear Packaging, Inc. (NuPac), PAS-1 cask is required to undergo annual maintenance and inspections to retain certification in accordance with U.S. Department of Energy (DOE) Certificate of Compliance USA/9184B(U) (Appendix A). The packaging configuration being tested and maintained is the NuPac PAS-1 cask for Payload B. The intent of the maintenance and inspections is to ensure the packaging remains in unimpaired physical condition. Two casks, serial numbers 2162-026 and 2162-027, were maintained, inspected, and tested at the 306E Development, Fabrication, and Test Laboratory, located at the Hanford Site's 300 Area. Waste Management Federal Services, Inc. (WMFS), a subsidiary of GTS Duratek, was in charge of the maintenance and testing. Cogema Engineering Corporation (Cogema) directed the operations in the test facility. The maintenance, testing, and inspections were conducted successfully with both PAS-1 casks. The work conducted on the overpacks included weighing, gasket replacement, and plastic pipe plug and foam inspections. The work conducted on the secondary containment vessel (SCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, and a helium leak test. The work conducted on the primary containment vessel (PCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, dimensional inspection of the vessel bottom, a helium leak test, and dye penetrant inspection of the welds. The vermiculite material used in the cask rack assembly was replaced.

  7. Understanding protected area resilience: a multi-scale, social-ecological approach

    USGS Publications Warehouse

    Cumming, Graeme S.; Allen, Craig R.; Ban, Natalie C.; Biggs, Duan; Biggs, Harry C.; Cumming, David H.M; De Vos, Alta; Epstein, Graham; Etienne, Michel; Maciejewski, Kristine; Mathevet, Raphael; Moore, Christine; Nenadovic, Mateja; Schoon, Michael

    2015-01-01

    Protected areas (PAs) remain central to the conservation of biodiversity. Classical PAs were conceived as areas that would be set aside to maintain a natural state with minimal human influence. However, global environmental change and growing cross-scale anthropogenic influences mean that PAs can no longer be thought of as ecological islands that function independently of the broader social-ecological system in which they are located. For PAs to be resilient (and to contribute to broader social-ecological resilience), they must be able to adapt to changing social and ecological conditions over time in a way that supports the long-term persistence of populations, communities, and ecosystems of conservation concern. We extend Ostrom's social-ecological systems framework to consider the long-term persistence of PAs, as a form of land use embedded in social-ecological systems, with important cross-scale feedbacks. Most notably, we highlight the cross-scale influences and feedbacks on PAs that exist from the local to the global scale, contextualizing PAs within multi-scale social-ecological functional landscapes. Such functional landscapes are integral to understand and manage individual PAs for long-term sustainability. We illustrate our conceptual contribution with three case studies that highlight cross-scale feedbacks and social-ecological interactions in the functioning of PAs and in relation to regional resilience. Our analysis suggests that while ecological, economic, and social processes are often directly relevant to PAs at finer scales, at broader scales, the dominant processes that shape and alter PA resilience are primarily social and economic.

  8. Adjustment as process and outcome: Measuring adjustment to HIV in Uganda.

    PubMed

    Martin, Faith; Russell, Steve; Seeley, Janet

    2016-05-01

    'Adjustment' in health refers to both processes and outcomes. Its measurement and conceptualisation in African cultures is limited. In total, 263 people living with HIV and receiving anti-retroviral therapy in clinics in Uganda completed a translated Mental Adjustment to HIV Scale, depression items from the Hopkins checklist and demographic questions. Factor analysis revealed four Mental Adjustment to HIV factors of active coping, cognitive-social adjustment, hopelessness and denial/avoidance. Correlations with depression supported the Mental Adjustment to HIV's validity and the importance of active adjustment, while the role of cognitive adjustment was unclear. Factors were process or outcome focussed, suggesting a need for theory-based measures in general. PMID:25030794

  9. Formation of the peroxisome lumen is abolished by loss of Pichia pastoris Pas7p, a zinc-binding integral membrane protein of the peroxisome.

    PubMed Central

    Kalish, J E; Theda, C; Morrell, J C; Berg, J M; Gould, S J

    1995-01-01

    We have cloned and sequenced PAS7, a gene required for peroxisome assembly in the yeast Pichia pastoris. The product of this gene, Pas7p, is a member of the C3HC4 superfamily of zinc-binding proteins. Point mutations that alter conserved residues of the C3HC4 motif abolish PAS7 activity and reduce zinc binding, suggesting that Pas7p binds zinc in vivo and that zinc binding is essential for PAS7 function. As with most pas mutants, pas7 cells exhibit a pronounced deficiency in import of peroxisomal matrix proteins that contain either the type 1 peroxisomal targeting signal (PTS1) or the type 2 PTS (PTS2). However, while other yeast and mammalian pas mutants accumulate ovoid, vesicular peroxisomal intermediates, loss of Pas7p leads to accumulation of membrane sheets and vesicles which lack a recognizable lumen. Thus, Pas7p appears to be essential for protein translocation into peroxisomes as well as formation of the lumen of the organelle. Consistent with these data, we find that Pas7p is an integral peroxisomal membrane protein which is entirely resistant to exogenous protease and thus appears to reside completely within the peroxisome. Our observations suggest that the function of Pas7p defines a previously unrecognized step in peroxisome assembly: formation of the peroxisome lumen. Furthermore, because the peroxisomal intermediates in the pas7 delta mutant proliferate in response to peroxisome-inducing environmental conditions, we conclude that Pas7p is not required for peroxisome proliferation. PMID:7565793

  10. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

    NASA Astrophysics Data System (ADS)

    Makino, Yuichi; Cao, Renhai; Svensson, Kristian; Bertilsson, Göran; Asman, Mikael; Tanaka, Hirotoshi; Cao, Yihai; Berkenstam, Anders; Poellinger, Lorenz

    2001-11-01

    Alteration of gene expression is a crucial component of adaptive responses to hypoxia. These responses are mediated by hypoxia-inducible transcription factors (HIFs). Here we describe an inhibitory PAS (Per/Arnt/Sim) domain protein, IPAS, which is a basic helix-loop-helix (bHLH)/PAS protein structurally related to HIFs. IPAS contains no endogenous transactivation function but demonstrates dominant negative regulation of HIF-mediated control of gene expression. Ectopic expression of IPAS in hepatoma cells selectively impairs induction of genes involved in adaptation to a hypoxic environment, notably the vascular endothelial growth factor (VEGF) gene, and results in retarded tumour growth and tumour vascular density in vivo. In mice, IPAS was predominantly expressed in Purkinje cells of the cerebellum and in corneal epithelium of the eye. Expression of IPAS in the cornea correlates with low levels of expression of the VEGF gene under hypoxic conditions. Application of an IPAS antisense oligonucleotide to the mouse cornea induced angiogenesis under normal oxygen conditions, and demonstrated hypoxia-dependent induction of VEGF gene expression in hypoxic corneal cells. These results indicate a previously unknown mechanism for negative regulation of angiogenesis and maintenance of an avascular phenotype.

  11. Topological control of the Caulobacter cell cycle circuitry by a polarized single-domain PAS protein

    PubMed Central

    Sanselicio, Stefano; Bergé, Matthieu; Théraulaz, Laurence; Radhakrishnan, Sunish Kumar; Viollier, Patrick H.

    2015-01-01

    Despite the myriad of different sensory domains encoded in bacteria, only a few types are known to control the cell cycle. Here we use a forward genetic screen for Caulobacter crescentus motility mutants to identify a conserved single-domain PAS (Per-Arnt-Sim) protein (MopJ) with pleiotropic regulatory functions. MopJ promotes re-accumulation of the master cell cycle regulator CtrA after its proteolytic destruction is triggered by the DivJ kinase at the G1-S transition. MopJ and CtrA syntheses are coordinately induced in S-phase, followed by the sequestration of MopJ to cell poles in Caulobacter. Polarization requires Caulobacter DivJ and the PopZ polar organizer. MopJ interacts with DivJ and influences the localization and activity of downstream cell cycle effectors. Because MopJ abundance is upregulated in stationary phase and by the alarmone (p)ppGpp, conserved systemic signals acting on the cell cycle and growth phase control are genetically integrated through this conserved single PAS-domain protein. PMID:25952018

  12. A novel source of MeV positron bunches driven by energetic protons for PAS application

    NASA Astrophysics Data System (ADS)

    Tan, Zongquan; Xu, Wenzhen; Liu, Yanfen; Xiao, Ran; Kong, Wei; Ye, Bangjiao

    2014-11-01

    This paper proposes a novel methodology of MeV positrons generation for PAS application. Feasibility of this proposal analyzed by G4Beamline and Transport have shown reasonable success. Using 2 Hz, 1.6 GeV, 100 ns and 1.5 μC/bunch proton bunches for bombarding a graphite target, about 100 ns e+ bunches are generated. Quasi-monochromatic positrons in the range of 1-10 MeV included in these bunches have a flux of >107/s, peak brightness of 1014/s. A magnetic-confinement beamline is utilized to transport the positrons and a "Fast Beam Chopper" is unprecedentedly extended to chop those relativistic bunches. The positron beam can be finally characterized by the energy range of 1-10 MeV and bunch width from one hundred ps up to 1 ns. Such ultrashort bunches can be useful in tomography-type positron annihilation spectroscopy (PAS) as well as other applications.

  13. Psychometric Evaluation of the Mountain Shadows Phonemic Awareness Scale with a Kindergarten Sample

    ERIC Educational Resources Information Center

    Nelson, Jason M.

    2008-01-01

    This study investigated the psychometric properties of a group-administered early literacy measure, the Mountain Shadows Phonemic Awareness Scale (MS-PAS), using a kindergarten sample (N = 213). The MS-PAS was compared to the "Test of Phonological Awareness-Second Edition: Plus" (TOPA-2+). Results indicated excellent internal consistency for the…

  14. Molecular cloning, expression and immunological characterisation of Pas n 1, the major allergen of Bahia grass Paspalum notatum pollen.

    PubMed

    Davies, Janet M; Mittag, Diana; Dang, Thanh D; Symons, Karen; Voskamp, Astrid; Rolland, Jennifer M; O'Hehir, Robyn E

    2008-12-01

    Bahia grass, Paspalum notatum, is a clinically important subtropical grass with a prolonged pollination season from spring to autumn. We aimed to clone and characterise the major Bahia grass pollen allergen, Pas n 1. Grass pollen-allergic patients presenting to a tertiary hospital allergy clinic were tested for IgE reactivity with Bahia grass pollen extract by skin prick testing, ImmunoCAP, ELISA and immunoblotting. Using primers deduced from the N-terminal peptide sequence of a group 1 allergen of Bahia grass pollen extract separated by two-dimensional gel electrophoresis, the complete Pas n 1 cDNA was obtained by rapid amplification of cDNA ends and cloned. Biological relevance of recombinant Pas n 1 expressed in Escherichia coli was assessed by serum IgE reactivity and basophil activation. Twenty-nine of 34 (85%) consecutive patients presenting with grass pollen allergy were skin prick test positive to Bahia grass pollen. The Pas n 1 cDNA has sequence homology with the beta-expansin 1 glycoprotein family and is more closely related to the maize pollen group 1 allergen (85% identity) than to ryegrass Lol p 1 or Timothy grass Phl p 1 (64 and 66% identity, respectively). rPas n 1 reacted with serum IgE in 47 of 55 (85%) Bahia grass pollen-allergic patients, activated basophils and inhibited serum IgE reactivity with the 29 kDa band of Bahia grass pollen extract. In conclusion the cDNA for the major group 1 allergen of the subtropical Bahia grass pollen, Pas n 1, was identified and cloned. rPas n 1 is immunologically active and is a valuable reagent for diagnosis and specific immunotherapy of grass pollen allergy. PMID:18817975

  15. Application of FTIR-PAS and Raman spectroscopies for the determination of organic matter in farmland soils.

    PubMed

    Xing, Zhe; Du, Changwen; Tian, Kang; Ma, Fei; Shen, Yazhen; Zhou, Jianmin

    2016-09-01

    In soil analysis, Raman spectroscopy is not as widely used as infrared spectroscopy mainly owing to fluorescence interferences. This paper investigated the feasibility of Fourier-transform infrared photoacoustic (FTIR-PAS) and Raman spectroscopies for predicting soil organic matter (SOM) using partial least squares regression (PLSR) analysis. 194 farmland soil samples were collected and scanned with FTIR and Raman spectrometers in the spectral range of 4000-400cm(-1) and 180-3200cm(-1), respectively. For the PLSR models, the combined dataset was split into 146 samples as the calibration set (75%) and 48 samples as the validation set (25%). The optimal number of analytical factors was determined using a leave-one-out cross-validation. The results showed that SOM could be predicted using FTIR-PAS and Raman spectroscopies independently, with R(2)>0.70 and RPD>1.8 for the validation sets. In comparison to the single applications of FTIR-PAS and Raman spectroscopies, accurate prediction of SOM was made by combining FTIR-PAS and Raman spectroscopies, with R(2)=0.81 and RPD=2.18 for the validation sets. By statistically assessing large amounts of PLS models, model-population analysis confirmed that the accuracy of the PLS model can be increased by combining FTIR-PAS and Raman spectroscopies. In conclusion, the combination of FTIR-PAS and Raman spectroscopies is a promising alternative for soil characterization, especially for the prediction of SOM, owing to the availability of complementary information from both FTIR-PAS (polar vibrations) and Raman spectroscopy (non-polar vibrations). PMID:27343604

  16. Adjusting the Chain Gear

    NASA Astrophysics Data System (ADS)

    Koloc, Z.; Korf, J.; Kavan, P.

    The adjustment (modification) deals with gear chains intermediating (transmitting) motion transfer between the sprocket wheels on parallel shafts. The purpose of the adjustments of chain gear is to remove the unwanted effects by using the chain guide on the links (sliding guide rail) ensuring a smooth fit of the chain rollers into the wheel tooth gap.

  17. Adjustment to Recruit Training.

    ERIC Educational Resources Information Center

    Anderson, Betty S.

    The thesis examines problems of adjustment encountered by new recruits entering the military services. Factors affecting adjustment are discussed: the recruit training staff and environment, recruit background characteristics, the military's image, the changing values and motivations of today's youth, and the recruiting process. Sources of…

  18. SLIT ADJUSTMENT CLAMP

    DOEpatents

    McKenzie, K.R.

    1959-07-01

    An electrode support which permits accurate alignment and adjustment of the electrode in a plurality of planes and about a plurality of axes in a calutron is described. The support will align the slits in the electrode with the slits of an ionizing chamber so as to provide for the egress of ions. The support comprises an insulator, a leveling plate carried by the insulator and having diametrically opposed attaching screws screwed to the plate and the insulator and diametrically opposed adjusting screws for bearing against the insulator, and an electrode associated with the plate for adjustment therewith.

  19. CMS Frailty Adjustment Model

    PubMed Central

    Kautter, John; Pope, Gregory C.

    2004-01-01

    The authors document the development of the CMS frailty adjustment model, a Medicare payment approach that adjusts payments to a Medicare managed care organization (MCO) according to the functional impairment of its community-residing enrollees. Beginning in 2004, this approach is being applied to certain organizations, such as Program of All-Inclusive Care for the Elderly (PACE), that specialize in providing care to the community-residing frail elderly. In the future, frailty adjustment could be extended to more Medicare managed care organizations. PMID:25372243

  20. Validating a Psychology as a Helping Profession Scale

    ERIC Educational Resources Information Center

    Gervasio, Amy Herstein; Wendorf, Craig A.; Yoder, Natalie F.

    2010-01-01

    We developed an 11-item Psychology as a Helping Profession (PHP) scale that measured aspects of personal growth/helping skills and applied helping. The scale was only weakly correlated with Friedrich's (1996) Psychology as Science (PAS) scale, implying that the 2 scales measure different conceptions of the nature of psychology. Psychology majors…

  1. [Evaluation of the website of the Nord-Pas-de-Calais regional pharmacovigilance center].

    PubMed

    Rochoy, Michaël; Béné, Johana; Messaadi, Nassir; Auffret, Marine; Gautier, Sophie

    2016-06-01

    We posted the Nord-Pas-de-Calais regional pharmacovigilance center website and distributed a survey to its potential users between August 2014 and October 2014 (135 general practitioners, 45 pharmacists, 14 patients). Satisfaction was 7.3±1.6 out of 10 points for the visual aspect, 7.8±1.5 out of 10 points for navigation and 7.6±1.4 out of 10 points for content. The website was declared useful by 98% respondents, particularly for the reporting of adverse drugs reactions (89%). PMID:27235657

  2. The Type Ia Supernova Pipeline for the Javalambre Physics of the Accelerating Universe Astrophysical Survey (J-PAS)

    NASA Astrophysics Data System (ADS)

    Siffert, B. B.; Reis, R. R. R.; Calvão, M. O.

    2014-10-01

    The Javalambre Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is an astronomical facility being built in Sierra de Javalambre, Spain. The main goal is to study the expansion of the Universe through different cosmological observables such as baryonic acoustic oscillations, type Ia supernovae and galaxy clusters. The main instrument will be a 2.5 m telescope equipped with a system of 56 narrow band filters in the optical. Here we present a sketch of the pipeline we are developing to detect type Ia supernovae with J-PAS. First we describe each individual step of the pipeline, such as image subtraction and source selection. Then we show some results we obtained when applying our pipeline to images from the Sloan Digital Sky Survey and the ALHAMBRA survey, which had a set of narrow band filters similar to the ones that will be used by J-PAS.

  3. A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni

    PubMed Central

    Reuter, Mark; Periago, Paula M.; Mulholland, Francis; Brown, Helen L.; van Vliet, Arnoud H. M.

    2015-01-01

    The bipolar flagella of the foodborne bacterial pathogen Campylobacter jejuni confer motility, which is essential for virulence. The flagella of C. jejuni are post-translationally modified, but how this process is controlled is not well understood. In this work, we have identified a novel PAS-domain containing regulatory system, which modulates flagella-flagella interactions in C. jejuni. Inactivation of the cj1387c gene, encoding a YheO-like PAS6 domain linked to a helix-turn-helix domain, resulted in the generation of a tightly associated “cell-train” morphotype, where up to four cells were connected by their flagella. The morphotype was fully motile, resistant to vortexing, accompanied by increased autoagglutination, and was not observed in aflagellated cells. The Δcj1387c mutant displayed increased expression of the adjacent Cj1388 protein, which comprises of a single endoribonuclease L-PSP domain. Comparative genomics showed that cj1387c (yheO) orthologs in bacterial genomes are commonly linked to an adjacent cj1388 ortholog, with some bacteria, including C. jejuni, containing another cj1388-like gene (cj0327). Inactivation of the cj1388 and cj0327 genes resulted in decreased autoagglutination in Tween-20-supplemented media. The Δcj1388 and Δcj0327 mutants were also attenuated in a Galleria larvae-based infection model. Finally, substituting the sole cysteine in Cj1388 for serine prevented Cj1388 dimerization in non-reducing conditions, and resulted in decreased autoagglutination in the presence of Tween-20. We hypothesize that Cj1388 and Cj0327 modulate post-translational modification of the flagella through yet unidentified mechanisms, and propose naming Cj1387 the Campylobacter Flagella Interaction Regulator CfiR, and the Cj1388 and Cj0327 protein as CfiP and CfiQ, respectively. PMID:26284050

  4. Remotely Adjustable Hydraulic Pump

    NASA Technical Reports Server (NTRS)

    Kouns, H. H.; Gardner, L. D.

    1987-01-01

    Outlet pressure adjusted to match varying loads. Electrohydraulic servo has positioned sleeve in leftmost position, adjusting outlet pressure to maximum value. Sleeve in equilibrium position, with control land covering control port. For lowest pressure setting, sleeve shifted toward right by increased pressure on sleeve shoulder from servovalve. Pump used in aircraft and robots, where hydraulic actuators repeatedly turned on and off, changing pump load frequently and over wide range.

  5. Protein Alpha Shape (PAS) Dock: a new gaussian-based score function suitable for docking in homology modelled protein structures.

    PubMed

    Tøndel, Kristin; Anderssen, Endre; Drabløs, Finn

    2006-03-01

    Protein Alpha Shape (PAS) Dock is a new empirical score function suitable for virtual library screening using homology modelled protein structures. Here, the score function is used in combination with the geometry search method Tabu search. A description of the protein binding site is generated using gaussian property fields like in Protein Alpha Shape Similarity Analysis (PASSA). Gaussian property fields are also used to describe the ligand properties. The overlap between the receptor and ligand hydrophilicity and lipophilicity fields is maximised, while minimising steric clashes. Gaussian functions introduce a smoothing of the property fields. This makes the score function robust against small structural variations, and therefore suitable for use with homology models. This also makes it less critical to include protein flexibility in the docking calculations. We use a fast and simplified version of the score function in the geometry search, while a more detailed version is used for the final prediction of the binding free energies. This use of a two-level scoring makes PAS-Dock computationally efficient, and well suited for virtual screening. The PAS-Dock score function is trained on 218 X-ray structures of protein- ligand complexes with experimental binding affinities. The performance of PAS-Dock is compared to two other docking methods, AutoDock and MOE-Dock, with respect to both accuracy and computational efficiency. According to this study, PAS-Dock is more computationally efficient than both AutoDock and MOE-Dock, and gives a better prediction of the free energies of binding. PAS-Dock is also more robust against structural variations than AutoDock. PMID:16652207

  6. Weighted triangulation adjustment

    USGS Publications Warehouse

    Anderson, Walter L.

    1969-01-01

    The variation of coordinates method is employed to perform a weighted least squares adjustment of horizontal survey networks. Geodetic coordinates are required for each fixed and adjustable station. A preliminary inverse geodetic position computation is made for each observed line. Weights associated with each observed equation for direction, azimuth, and distance are applied in the formation of the normal equations in-the least squares adjustment. The number of normal equations that may be solved is twice the number of new stations and less than 150. When the normal equations are solved, shifts are produced at adjustable stations. Previously computed correction factors are applied to the shifts and a most probable geodetic position is found for each adjustable station. Pinal azimuths and distances are computed. These may be written onto magnetic tape for subsequent computation of state plane or grid coordinates. Input consists of punch cards containing project identification, program options, and position and observation information. Results listed include preliminary and final positions, residuals, observation equations, solution of the normal equations showing magnitudes of shifts, and a plot of each adjusted and fixed station. During processing, data sets containing irrecoverable errors are rejected and the type of error is listed. The computer resumes processing of additional data sets.. Other conditions cause warning-errors to be issued, and processing continues with the current data set.

  7. PAS-Positive Extracellular Deposits within Germinal Centers of Hyperplastic Follicles during SIV infection in a Rhesus Macaque

    PubMed Central

    Hong, Jung Joo; Villinger, Francois; Courtney, Cynthia L

    2014-01-01

    Background Lymphoid tissue remodeling is characteristic of chronic SIV infection. Methods A rhesus macaque infected with SIVmac239 was necropsied and its lymphoid tissues subjected to histopathology characterization. Results Germinal centers in spleen and lymph nodes contained PAS-positive, non-amyloid extracellular deposits, decreased T follicular helper cells, and normal density of Ki67+ B cells. Conclusions A possible mechanism for PAS-positive deposits includes exaggerated involution of SIV-induced follicular hyperplasia secondary to virus-associated immune reaction. PMID:24628065

  8. Immunosuppressive PAS-1 is an excretory/secretory protein released by larval and adult worms of the ascarid nematode Ascaris suum.

    PubMed

    Antunes, M F P; Titz, T O; Batista, I F C; Marques-Porto, R; Oliveira, C F; Alves de Araujo, C A; Macedo-Soares, M F

    2015-05-01

    Helminths use several strategies to evade and/or modify the host immune response, including suppression or inactivation of the host antigen-specific response. Several helminth immunomodulatory molecules have been identified. Our studies have focused on immunosuppression induced by the roundworm Ascaris suum and an A. suum-derived protein named protein 1 from A. suum (PAS-1). Here we assessed whether PAS-1 is an excretory/secretory (E/S) protein and whether it can suppress lipopolysaccharide-induced inflammation. Larvae from infective eggs were cultured in unsupplemented Dulbecco's modified Eagle medium (DMEM) for 2 weeks. PAS-1 was then measured in the culture supernatants and in adult A. suum body fluid at different time points by enzyme-linked immunosorbent assay (ELISA) with the monoclonal antibody MAIP-1. Secreted PAS-1 was detected in both larval culture supernatant and adult body fluid. It suppressed lipopolysaccharide (LPS)-induced leucocyte migration and pro-inflammatory cytokine production, and stimulated interleukin (IL)-10 secretion, indicating that larval and adult secreted PAS-1 suppresses inflammation in this model. Moreover, the anti-inflammatory activity of PAS-1 was abolished by treatment with MAIP-1, a PAS-1-specific monoclonal antibody, confirming the crucial role of PAS-1 in suppressing LPS-induced inflammation. These findings demonstrate that PAS-1 is an E/S protein with anti-inflammatory properties likely to be attributable to IL-10 production. PMID:24703095

  9. Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells.

    PubMed

    Inoue, Hiroki; Ogonuki, Narumi; Hirose, Michiko; Hatanaka, Yuki; Matoba, Shogo; Chuma, Shinichiro; Kobayashi, Kimio; Wakana, Shigeharu; Noguchi, Junko; Inoue, Kimiko; Tanemura, Kentaro; Ogura, Atsuo

    2016-09-16

    D1Pas1 is a mouse autosomal DEAD-box RNA helicase expressed predominantly in the testis. To assess its possible function, we generated D1Pas1-deficient mice using embryonic stem cells with a targeted D1Pas1 allele. Deletion of D1Pas1 did not cause noticeable embryonic defects or death, indicating that D1Pas1 is not essential for embryogenesis. Whereas homozygous knockout female mice showed normal reproductive performance, homozygous knockout male mice were completely sterile. The seminiferous epithelium of D1Pas1-deficient males contained no spermatids or spermatozoa because of spermatogenic arrest at the late pachytene stage. Upregulation of retrotransposons such as LINE-1 was not found in D1Pas1-deficient males, unlike males lacking Mvh, another testicular DEAD-box RNA helicase. Meiotic chromosome behavior in developing spermatocytes of D1Pas1-deficient males was indistinguishable from that in wild-type males, at least until synaptonemal complex formation. Thus, mouse D1Pas1 is the first-identified DEAD-box RNA helicase that plays critical roles in the final step of the first meiotic prophase in male germ cells. PMID:27473657

  10. Partial covariate adjusted regression

    PubMed Central

    Şentürk, Damla; Nguyen, Danh V.

    2008-01-01

    Covariate adjusted regression (CAR) is a recently proposed adjustment method for regression analysis where both the response and predictors are not directly observed (Şentürk and Müller, 2005). The available data has been distorted by unknown functions of an observable confounding covariate. CAR provides consistent estimators for the coefficients of the regression between the variables of interest, adjusted for the confounder. We develop a broader class of partial covariate adjusted regression (PCAR) models to accommodate both distorted and undistorted (adjusted/unadjusted) predictors. The PCAR model allows for unadjusted predictors, such as age, gender and demographic variables, which are common in the analysis of biomedical and epidemiological data. The available estimation and inference procedures for CAR are shown to be invalid for the proposed PCAR model. We propose new estimators and develop new inference tools for the more general PCAR setting. In particular, we establish the asymptotic normality of the proposed estimators and propose consistent estimators of their asymptotic variances. Finite sample properties of the proposed estimators are investigated using simulation studies and the method is also illustrated with a Pima Indians diabetes data set. PMID:20126296

  11. Language Fluency and the Evaluation of Cultural Faux Pas: Russians Interviewing for Jobs in the United States

    ERIC Educational Resources Information Center

    Molinsky, Andrew

    2005-01-01

    How are nonnatives evaluated when committing cultural faux pas, and how does their fluency in the language of the foreign culture affect the evaluation of their culturally inappropriate behavior? I address these questions in the context of Russian professionals learning to interview for jobs in the United States, an arena of strong cultural…

  12. Biological control of Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) using Aeromonas phage PAS-1.

    PubMed

    Kim, J H; Choresca, C H; Shin, S P; Han, J E; Jun, J W; Park, S C

    2015-02-01

    The potential control efficacy of Aeromonas phage PAS-1 was evaluated against Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) model in this study. The phage was co-cultured with the virulent A. salmonicida subsp. salmonicida strain AS05 that possesses the type III secretion system (TTSS) ascV gene, and efficient bacteriolytic activity was observed against the bacteria. The administration of PAS-1 in rainbow trout demonstrated that the phage was cleared from the fish within 200 h post-administration, and a temporal neutralizing activity against the phage was detected in the sera of phage-administrated fish. The administration of PAS-1 (multiplicity of infection: 10 000) in A. salmonicida subsp. salmonicida infected rainbow trout model showed notable protective effects, with increased survival rates and mean times to death. These results demonstrated that Aeromonas phage PAS-1 could be considered as an alternative biological control agent against A. salmonicida subsp. salmonicida infections in rainbow trout culture. PMID:23594036

  13. Safety evaluation for packaging for the transport of K Basin sludge samples in the PAS-1 cask

    SciTech Connect

    SMITH, R.J.

    1998-11-17

    This safety evaluation for packaging authorizes the shipment of up to two 4-L sludge samples to and from the 325 Lab or 222-S Lab for characterization. The safety of this shipment is based on the current U.S. Department of Energy Certification of Compliance (CoC) for the PAS-1 cask, USA/9184/B(U) (DOE).

  14. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Security and Emergency Preparedness (NSEP) B Appendix B to Part 64 Telecommunication FEDERAL COMMUNICATIONS.... 64, App. B Appendix B to Part 64—Priority Access Service (PAS) for National Security and Emergency...'s Order to CMRS providers and users to comply with policies and procedures establishing the...

  15. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Security and Emergency Preparedness (NSEP) B Appendix B to Part 64 Telecommunication FEDERAL COMMUNICATIONS.... 64, App. B Appendix B to Part 64—Priority Access Service (PAS) for National Security and Emergency...'s Order to CMRS providers and users to comply with policies and procedures establishing the...

  16. Step-Scan T-Cell Fourier Transform Infrared Photoacoustic Spectroscopy (FTIR-PAS) for Monitoring Environmental Air Pollutants

    NASA Astrophysics Data System (ADS)

    Liu, Lixian; Mandelis, Andreas; Melnikov, Alexander; Michaelian, Kirk; Huan, Huiting; Haisch, Christoph

    2016-07-01

    Air pollutants have adverse effects on the Earth's climate system. There is an urgent need for cost-effective devices capable of recognizing and detecting various ambient pollutants. An FTIR photoacoustic spectroscopy (FTIR-PAS) method based on a commercial FTIR spectrometer developed for air contamination monitoring will be presented. A resonant T-cell was determined to be the most appropriate resonator in view of the low-frequency requirement and space limitations in the sample compartment. Step-scan FTIR-PAS theory for regular cylinder resonator has been described as a reference for prediction of T-cell vibration principles. Both simulated amplitude and phase responses of the T-cell show good agreement with measurement data Carbon dioxide IR absorption spectra were used to demonstrate the capacity of the FTIR-PAS method to detect ambient pollutants. The theoretical detection limit for carbon dioxide was found to be 4 ppmv. A linear response to carbon dioxide concentration was found in the range from 2500 ppmv to 5000 ppmv. The results indicate that it is possible to use step-scan FTIR-PAS with a T-cell as a quantitative method for analysis of ambient contaminants.

  17. The Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD) Checklist: Reliability and Validity of French Version

    ERIC Educational Resources Information Center

    Gerber, F.; Carminati, G. Galli

    2013-01-01

    Background: The lack of psychometric measures of psychopathology especially in intellectual disabilities (ID) population was addressed by creation of the Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD-10) in Moss et?al. This schedule is a structured interview designed for professionals in psychopathology. The…

  18. Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.

    PubMed

    Epstein, D J; Martinu, L; Michaud, J L; Losos, K M; Fan, C; Joyner, A L

    2000-11-01

    The secreted protein sonic hedgehog (Shh) is required to establish patterns of cellular growth and differentiation within ventral regions of the developing CNS. The expression of Shh in the two tissue sources responsible for this activity, the axial mesoderm and the ventral midline of the neural tube, is regulated along the anteroposterior neuraxis. Separate cis-acting regulatory sequences have been identified which direct Shh expression to distinct regions of the neural tube, supporting the view that multiple genes are involved in activating Shh transcription along the length of the CNS. We show here that the activity of one Shh enhancer, which directs reporter expression to portions of the ventral midbrain and diencephalon, overlaps both temporally and spatially with the expression of Sim2. Sim2 encodes a basic helix-loop-helix (bHLH-PAS) PAS domain containing transcriptional regulator whose Drosophila homolog, single-minded, is a master regulator of ventral midline development. Both vertebrate and invertebrate Sim family members were found sufficient for the activation of the Shh reporter as well as endogenous Shh mRNA. Although Shh expression is maintained in Sim2(-)(/)(-) embryos, it was determined to be absent from the rostral midbrain and caudal diencephalon of embryos carrying a dominant-negative transgene that disrupts the function of bHLH-PAS proteins. Together, these results suggest that bHLH-PAS family members are required for the regulation of Shh transcription within aspects of the ventral midbrain and diencephalon. PMID:11023872

  19. Minor-bodies science with the J-PAS/J-PLUS photometric surveys

    NASA Astrophysics Data System (ADS)

    De Prá, M.; Carvano, J.

    2014-07-01

    The JPAS/J-PLUS is a joint Spanish-Brazilian project that aims to map an area of the sky of 8000 square degrees, in order to measure, with unprecedented accuracy, the redshifts of a large sample of extragalactic objects up magnitude 23. It involves the installation of two telescopes on the Javalambre Mountains, in Spain. The T250 telescope will have an aperture of 250 cm and will be equipped with a camera with a 3 square degree field of view and will use a set of 56 filters (54 narrow band + 2 wide band) covering the 0.3--1.0 micron range, while the T80 telescope (presently on commissioning phase) will have a camera with 2 square degree field of view and will use a set of 12 narrow and intermediate band filters covering the same wavelength range. During its execution, the surveys will also observe a large number of minor Solar System bodies. For those objects, the differential of JPAS/J-PLUS with respect to other large photometric survey is the number and position of the filters used, which will allow a better identification of some taxonomic classes that are not well defined only with SDSS-like filter systems. In particular, the JPAS/J-PLUS data set will allow a robust identification of the 0.7 micron water alteration band that characterize the Ch class in Bus taxonomy. Thus, with JPAS/J-PLUS it will be possible to map the occurrence of water alteration in the present Solar System, which in turn will allow us to put further constraints of the presence of volatiles and of heating processes in the early Solar System. Also, although the survey cadence is not optimized for the discovery of minor bodies, J-PAS/J-PLUS can give an important contribution to the effort of expanding the known population of asteroids and TNOs. We will discuss also the expected efficiency of the J-PLUS/J-PAS surveys in finding minor bodies.

  20. An accurate cluster selection function for the J-PAS narrow-band wide-field survey

    NASA Astrophysics Data System (ADS)

    Ascaso, B.; Benítez, N.; Dupke, R.; Cypriano, E.; Lima-Neto, G.; López-Sanjuan, C.; Varela, J.; Alcaniz, J. S.; Broadhurst, T.; Cenarro, A. J.; Devi, N. Chandrachani; Díaz-García, L. A.; Fernandes, C. A. C.; Hernández-Monteagudo, C.; Mei, S.; Mendes de Oliveira, C.; Molino, A.; Oteo, I.; Schoenell, W.; Sodré, L.; Viironen, K.; Marín-Franch, A.

    2016-03-01

    The impending Javalambre Physics of the accelerating Universe Astrophysical Survey (J-PAS) will be the first wide-field survey of ≳ 8500 deg2 to reach the `stage IV' category. Because of the redshift resolution afforded by 54 narrow-band filters, J-PAS is particularly suitable for cluster detection in the range z<1. The photometric redshift dispersion is estimated to be only ˜0.003 with few outliers ≲4 per cent for galaxies brighter than i ˜ 23 AB, because of the sensitivity of narrow band imaging to absorption and emission lines. Here, we evaluate the cluster selection function for J-PAS using N-body+semi-analytical realistic mock catalogues. We optimally detect clusters from this simulation with the Bayesian Cluster Finder, and we assess the completeness and purity of cluster detection against the mock data. The minimum halo mass threshold we find for detections of galaxy clusters and groups with both >80 per cent completeness and purity is Mh ˜ 5 × 1013 M⊙ up to z ˜ 0.7. We also model the optical observable, M^{*}_CL-halo mass relation, finding a non-evolution with redshift and main scatter of σ _{M^{*}_CL | M_h}˜ 0.14 dex down to a factor 2 lower in mass than other planned broad-band stage IV surveys, at least. For the Mh ˜ 1 × 1014 M⊙ Planck mass limit, J-PAS will arrive up to z ˜ 0.85 with a σ _{M^{*}_CL | M_h}˜ 0.12 dex. Therefore, J-PAS will provide the largest sample of clusters and groups up to z ˜ 0.8 with a mass calibration accuracy comparable to X-ray data.

  1. Rural to Urban Adjustment

    ERIC Educational Resources Information Center

    Abramson, Jane A.

    Personal interviews with 100 former farm operators living in Saskatoon, Saskatchewan, were conducted in an attempt to understand the nature of the adjustment process caused by migration from rural to urban surroundings. Requirements for inclusion in the study were that respondents had owned or operated a farm for at least 3 years, had left their…

  2. Self adjusting inclinometer

    DOEpatents

    Hunter, Steven L.

    2002-01-01

    An inclinometer utilizing synchronous demodulation for high resolution and electronic offset adjustment provides a wide dynamic range without any moving components. A device encompassing a tiltmeter and accompanying electronic circuitry provides quasi-leveled tilt sensors that detect highly resolved tilt change without signal saturation.

  3. Self Adjusting Sunglasses

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Corning Glass Works' Serengeti Driver sunglasses are unique in that their lenses self-adjust and filter light while suppressing glare. They eliminate more than 99% of the ultraviolet rays in sunlight. The frames are based on the NASA Anthropometric Source Book.

  4. The Neuronal PAS Domain Protein 4 (Npas4) Is Required for New and Reactivated Fear Memories

    PubMed Central

    Nguyen, Tam; DiLeone, Ralph J.; Schafe, Glenn E.

    2011-01-01

    The Neuronal PAS domain protein 4 (Npas4) is a neuronal activity-dependent immediate early gene that has recently been identified as a transcription factor which regulates the transcription of genes that control inhibitory synapse development and synaptic plasticity. The role Npas4 in learning and memory, however, is currently unknown. Here, we systematically examine the role of Npas4 in auditory Pavlovian fear conditioning, an amygdala-dependent form of emotional learning. In our first series of experiments, we show that Npas4 mRNA and protein are regulated in the rat lateral nucleus of the amygdala (LA) in a learning-dependent manner. Further, knockdown of Npas4 protein in the LA via adeno-associated viral (AAV) mediated gene delivery of RNAi was observed to impair fear memory formation, while innate fear and the expression of fear memory were not affected. In our second series of experiments, we show that Npas4 protein is regulated in the LA by retrieval of an auditory fear memory and that knockdown of Npas4 in the LA impairs retention of a reactivated, but not a non-reactivated, fear memory. Collectively, our findings provide the first comprehensive look at the functional role of Npas4 in learning and memory. PMID:21887312

  5. iPAS: AES Flight System Technology Maturation for Human Spaceflight

    NASA Technical Reports Server (NTRS)

    Othon, William L.

    2014-01-01

    In order to realize the vision of expanding human presence in space, NASA will develop new technologies that can enable future crewed spacecraft to go far beyond Earth orbit. These technologies must be matured to the point that future project managers can accept the risk of incorporating them safely and effectively within integrated spacecraft systems, to satisfy very challenging mission requirements. The technologies must also be applied and managed within an operational context that includes both on-board crew and mission support on Earth. The Advanced Exploration Systems (AES) Program is one part of the NASA strategy to identify and develop key capabilities for human spaceflight, and mature them for future use. To support this initiative, the Integrated Power Avionics and Software (iPAS) environment has been developed that allows engineers, crew, and flight operators to mature promising technologies into applicable capabilities, and to assess the value of these capabilities within a space mission context. This paper describes the development of the integration environment to support technology maturation and risk reduction, and offers examples of technology and mission demonstrations executed to date.

  6. Family Background, Adolescent Coping Styles, and Adjustment.

    ERIC Educational Resources Information Center

    Schludermann, Shirin; And Others

    This study explored the effects of family background variables on coping styles, and the contribution of coping styles and locus of control to the overall adjustment of older adolescents. The objectives of this study were to develop a Canadian adaptation of the Seiffge-Krenke Adolescent Coping Style Scale; to explore the influences of family and…

  7. Precision adjustable stage

    DOEpatents

    Cutburth, Ronald W.; Silva, Leonard L.

    1988-01-01

    An improved mounting stage of the type used for the detection of laser beams is disclosed. A stage center block is mounted on each of two opposite sides by a pair of spaced ball bearing tracks which provide stability as well as simplicity. The use of the spaced ball bearing pairs in conjunction with an adjustment screw which also provides support eliminates extraneous stabilization components and permits maximization of the area of the center block laser transmission hole.

  8. Adjustable Autonomy Testbed

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Schrenkenghost, Debra K.

    2001-01-01

    The Adjustable Autonomy Testbed (AAT) is a simulation-based testbed located in the Intelligent Systems Laboratory in the Automation, Robotics and Simulation Division at NASA Johnson Space Center. The purpose of the testbed is to support evaluation and validation of prototypes of adjustable autonomous agent software for control and fault management for complex systems. The AA T project has developed prototype adjustable autonomous agent software and human interfaces for cooperative fault management. This software builds on current autonomous agent technology by altering the architecture, components and interfaces for effective teamwork between autonomous systems and human experts. Autonomous agents include a planner, flexible executive, low level control and deductive model-based fault isolation. Adjustable autonomy is intended to increase the flexibility and effectiveness of fault management with an autonomous system. The test domain for this work is control of advanced life support systems for habitats for planetary exploration. The CONFIG hybrid discrete event simulation environment provides flexible and dynamically reconfigurable models of the behavior of components and fluids in the life support systems. Both discrete event and continuous (discrete time) simulation are supported, and flows and pressures are computed globally. This provides fast dynamic simulations of interacting hardware systems in closed loops that can be reconfigured during operations scenarios, producing complex cascading effects of operations and failures. Current object-oriented model libraries support modeling of fluid systems, and models have been developed of physico-chemical and biological subsystems for processing advanced life support gases. In FY01, water recovery system models will be developed.

  9. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.

    PubMed

    Reischauer, Sven; Stone, Oliver A; Villasenor, Alethia; Chi, Neil; Jin, Suk-Won; Martin, Marcel; Lee, Miler T; Fukuda, Nana; Marass, Michele; Witty, Alec; Fiddes, Ian; Kuo, Taiyi; Chung, Won-Suk; Salek, Sherveen; Lerrigo, Robert; Alsiö, Jessica; Luo, Shujun; Tworus, Dominika; Augustine, Sruthy M; Mucenieks, Sophie; Nystedt, Björn; Giraldez, Antonio J; Schroth, Gary P; Andersson, Olov; Stainier, Didier Y R

    2016-07-14

    Vascular and haematopoietic cells organize into specialized tissues during early embryogenesis to supply essential nutrients to all organs and thus play critical roles in development and disease. At the top of the haemato-vascular specification cascade lies cloche, a gene that when mutated in zebrafish leads to the striking phenotype of loss of most endothelial and haematopoietic cells and a significant increase in cardiomyocyte numbers. Although this mutant has been analysed extensively to investigate mesoderm diversification and differentiation and continues to be broadly used as a unique avascular model, the isolation of the cloche gene has been challenging due to its telomeric location. Here we used a deletion allele of cloche to identify several new cloche candidate genes within this genomic region, and systematically genome-edited each candidate. Through this comprehensive interrogation, we succeeded in isolating the cloche gene and discovered that it encodes a PAS-domain-containing bHLH transcription factor, and that it is expressed in a highly specific spatiotemporal pattern starting during late gastrulation. Gain-of-function experiments show that it can potently induce endothelial gene expression. Epistasis experiments reveal that it functions upstream of etv2 and tal1, the earliest expressed endothelial and haematopoietic transcription factor genes identified to date. A mammalian cloche orthologue can also rescue blood vessel formation in zebrafish cloche mutants, indicating a highly conserved role in vertebrate vasculogenesis and haematopoiesis. The identification of this master regulator of endothelial and haematopoietic fate enhances our understanding of early mesoderm diversification and may lead to improved protocols for the generation of endothelial and haematopoietic cells in vivo and in vitro. PMID:27411634

  10. The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation.

    PubMed

    Wellberg, Elizabeth; Metz, Richard P; Parker, Caitlin; Porter, Weston W

    2010-03-01

    We have previously demonstrated that the bHLH/PAS transcription factor, singleminded 2s (Sim2s), is required for proper mammary ductal morphogenesis and luminal epithelial differentiation. Furthermore, loss of Sim2s in breast cancer cells resulted in downregulation of epithelial markers and acquisition of a basal-like phenotype. The objective of this study was to further define the role of Sim2s in mammary differentiation. We found that Sim2s is developmentally regulated throughout mammary gland development with highest expression during lactation. Mammary glands from nulliparous mice expressing Sim2s driven by the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter were morphologically indistinguishable from wild-type mice but displayed hallmarks of precocious lactogenic differentiation. These included elevated expression of the milk protein genes Wap and Csn2, and apical localization of the lactation marker Npt2b. Consistent with the in vivo results, Sim2s enhanced prolactin-mediated Csn2 expression in HC11 and CIT3 mouse mammary epithelial cells, and downregulation of Sim2s by shRNA in HC11 cells inhibited Csn2 expression. Chromatin immunoprecipitation (ChIP) analyses of the Csn2 gene found that Sim2s associates with the Csn2 promoter and re-ChIP experiments showed that Sim2s interacted with the RNA II polymerase (RNAPII) complex. Together, these data demonstrate, for the first time, that Sim2s is required for establishing and maintaining mammary gland differentiation. PMID:20150276

  11. Toxic pyrrolizidinalkaloids as undesired contaminants in food and feed: degradation of the PAs from Senecio jacobaea in silage.

    PubMed

    Becerra-Jiminez, J; Kuschak, M; Roeder, E; Wiedenfeld, H

    2013-07-01

    Pyrrolizidine alkaloids (PAs) can show a hazardous potential for men and animals. They can act as cancerogenic, mutagenic, teratogenic and fetotoxic agents. One pathway of a human intoxication is its occurence as contaminants in food and feed. Here, the contamination of cereals already led to severe and fatal intoxication episodes. Besides this, milk is of special concern as it is the main food for children which show a very high susceptibility for a PA intoxication. Milk can contain PAs in case the milk producing animals have access to contaminated feed. In this context it is of special interest whether the PA content of contaminated silage remains stable during the ensiling procedure or show a more or less high level of decomposition. We could show that ensiling will not lead to PA-free silage. PMID:23923650

  12. Determination of drug content in semisolid formulations by non-invasive spectroscopic methods: FTIR - ATR, - PAS, - Raman and PDS

    NASA Astrophysics Data System (ADS)

    Gotter, B.; Faubel, W.; Heißler, St.; Hein, J.; Neubert, R. H. H.

    2010-03-01

    This study elucidates the potential use of photothermal deflection spectroscopy (PDS), FTIR photoacoustic (FTIR-PAS), FT Raman, and FTIR-attenuated total reflection (FTIR-ATR) spectroscopy as analytical tools for investigating the drug content in semisolid formulations. Regarding the analytical parameters, this study demonstrates the photothermal beam deflection to be definitely comparable to well established spectroscopic methods for this purpose. The correlation coefficients range from 0.990 to 0.999. Likewise, repeatability and limit of detection are comparable.

  13. Identification of functional groups on the surface of modified organic materials using the FT-IR/PAS method

    NASA Astrophysics Data System (ADS)

    Hofman, M.; Pasieczna-Patkowska, S.; Ryczkowski, J.; Wachowski, L.

    2008-02-01

    Interactions between NO and the surface of waste plum stones have been studied by FTIR-PAS in order to identify the nitrogen species formed. It is possible that there are some additional active centres generated on their surface. Identification of surface functional groups was needed to characterize their influence on the properties of obtained materials which were used as catalyst support in our further research.

  14. Television as Textbook: "Cuéntame cómo pasó" in the Spanish (Literature) Classroom

    ERIC Educational Resources Information Center

    Bartlett, Linda; Manyé, Lourdes

    2015-01-01

    The long-running Spanish television program "Cuéntame cómo pasó" represents not only a wildly successful series for Radio Televisión Española, but also an excellent example of the project of historical memory. Premiering in 2001 (but set, in the first season, in 1968), the story of the multigenerational Alcántara family forms a…

  15. Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking

    PubMed Central

    Militi, Stefania; Maywood, Elizabeth S.; Sandate, Colby R.; Chesham, Johanna E.; Parsons, Michael J.; Vibert, Jennifer L.; Joynson, Greg M.; Partch, Carrie L.; Hastings, Michael H.; Nolan, Patrick M.

    2016-01-01

    The suprachiasmatic nucleus (SCN) defines 24 h of time via a transcriptional/posttranslational feedback loop in which transactivation of Per (period) and Cry (cryptochrome) genes by BMAL1–CLOCK complexes is suppressed by PER–CRY complexes. The molecular/structural basis of how circadian protein complexes function is poorly understood. We describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early doors (Edo), in the PER-ARNT-SIM (PAS) domain dimerization region of period 2 (PER2) (I324N) that accelerates the circadian clock of Per2Edo/Edo mice by 1.5 h. Structural and biophysical analyses revealed that Edo alters the packing of the highly conserved interdomain linker of the PER2 PAS core such that, although PER2Edo complexes with clock proteins, its vulnerability to degradation mediated by casein kinase 1ε (CSNK1E) is increased. The functional relevance of this mutation is revealed by the ultrashort (<19 h) but robust circadian rhythms in Per2Edo/Edo; Csnk1eTau/Tau mice and the SCN. These periods are unprecedented in mice. Thus, Per2Edo reveals a direct causal link between the molecular structure of the PER2 PAS core and the pace of SCN circadian timekeeping. PMID:26903623

  16. Transient expression of Nxf, a bHLH-PAS transactivator induced by neuronal preconditioning, confers neuroprotection in cultured cells.

    PubMed

    Hester, Ian; McKee, Sarah; Pelletier, Phillip; Thompson, Charles; Storbeck, Christopher; Mears, Alan; Schulz, Jörg B; Hakim, Antoine A; Sabourin, Luc A

    2007-03-01

    Cortical spreading depression (CSD) induces waves of neuronal depolarization that confer neuroprotection to subsequent ischemic events in the rat brain. To gain insights into the molecular mechanisms elicited by CSD, we used representational difference analysis (RDA) to identify mRNAs induced by potassium depolarization in vivo. Using this approach, we have isolated a cDNA encoding the SIM2-related bHLH-PAS protein Nxf. Our results confirm that Nxf mRNA and protein are rapidly and transiently expressed in cortical neurons following CSD. Reporter assays show that Nxf is a transcriptional activator that associates with the bHLH-PAS sub-class co-factor ARNT2. Adenovirus-mediated expression of epitope-tagged Nxf results in cell death and the direct activation of the Bax gene in cultured cells. However, RNA interference studies show that endogenous Nxf is required for optimal neuroprotection by preconditioning in cultured F-11 cells. Together, our data indicate that Nxf is a novel bHLH-PAS transactivator transiently induced by preconditioning and that its sustained expression is detrimental. The identification of Nxf may represent an important step in our understanding of the molecular mechanisms of brain preconditioning and injury. PMID:17214977

  17. Low-dose radiation pretreatment improves survival of human ceiling culture-derived proliferative adipocytes (ccdPAs) under hypoxia via HIF-1 alpha and MMP-2 induction

    SciTech Connect

    Adachi, Naoki; Kubota, Yoshitaka; Kosaka, Kentarou; Akita, Shinsuke; Sasahara, Yoshitarou; Kira, Tomoe; Kuroda, Masayuki; Mitsukawa, Nobuyuki; Bujo, Hideaki; Satoh, Kaneshige

    2015-08-07

    Poor survival is a major problem of adipocyte transplantation. We previously reported that VEGF and MMPs secreted from transplanted adipocytes are essential for angiogenesis and adipogenesis. Pretreatment with low-dose (5 Gy) radiation (LDR) increased VEGF, MMP-2, and HIF-1 alpha mRNA expression in human ceiling culture-derived proliferative adipocytes (hccdPAs). Gene expression after LDR differed between adipose-derived stem cells (hASCs) and hccdPAs. Pretreatment with LDR improved the survival of hccdPAs under hypoxia, which is inevitable in the early stages after transplantation. Upregulation of VEGF and MMP-2 after LDR in hccdPAs is mediated by HIF-1 alpha expression. Our results suggest that pretreatment with LDR may improve adipocyte graft survival in a clinical setting through upregulation of VEGF and MMP-2 via HIF-1 alpha. - Highlights: • Ceiling culture-derived proliferative adipocytes (ccdPAs) react to radiation. • Low-dose radiation (LDR) pretreatment improves survival of ccdPAs under hypoxia. • Gene expression after LDR differs between ccdPAs and adipose-derived stem cells. • LDR-induced increase in MMP-2 and VEGF is dependent on HIF-1 alpha induction. • LDR pretreatment may improve the adipocyte graft survival rate in clinical settings.

  18. A comprehensive protein–protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1

    PubMed Central

    DeMille, Desiree; Bikman, Benjamin T.; Mathis, Andrew D.; Prince, John T.; Mackay, Jordan T.; Sowa, Steven W.; Hall, Tacie D.; Grose, Julianne H.

    2014-01-01

    Per-Arnt-Sim (PAS) kinase is a sensory protein kinase required for glucose homeostasis in yeast, mice, and humans, yet little is known about the molecular mechanisms of its function. Using both yeast two-hybrid and copurification approaches, we identified the protein–protein interactome for yeast PAS kinase 1 (Psk1), revealing 93 novel putative protein binding partners. Several of the Psk1 binding partners expand the role of PAS kinase in glucose homeostasis, including new pathways involved in mitochondrial metabolism. In addition, the interactome suggests novel roles for PAS kinase in cell growth (gene/protein expression, replication/cell division, and protein modification and degradation), vacuole function, and stress tolerance. In vitro kinase studies using a subset of 25 of these binding partners identified Mot3, Zds1, Utr1, and Cbf1 as substrates. Further evidence is provided for the in vivo phosphorylation of Cbf1 at T211/T212 and for the subsequent inhibition of respiration. This respiratory role of PAS kinase is consistent with the reported hypermetabolism of PAS kinase–deficient mice, identifying a possible molecular mechanism and solidifying the evolutionary importance of PAS kinase in the regulation of glucose homeostasis. PMID:24850888

  19. Continuously adjustable Pulfrich spectacles

    NASA Astrophysics Data System (ADS)

    Jacobs, Ken; Karpf, Ron

    2011-03-01

    A number of Pulfrich 3-D movies and TV shows have been produced, but the standard implementation has inherent drawbacks. The movie and TV industries have correctly concluded that the standard Pulfrich 3-D implementation is not a useful 3-D technique. Continuously Adjustable Pulfrich Spectacles (CAPS) is a new implementation of the Pulfrich effect that allows any scene containing movement in a standard 2-D movie, which are most scenes, to be optionally viewed in 3-D using inexpensive viewing specs. Recent scientific results in the fields of human perception, optoelectronics, video compression and video format conversion are translated into a new implementation of Pulfrich 3- D. CAPS uses these results to continuously adjust to the movie so that the viewing spectacles always conform to the optical density that optimizes the Pulfrich stereoscopic illusion. CAPS instantly provides 3-D immersion to any moving scene in any 2-D movie. Without the glasses, the movie will appear as a normal 2-D image. CAPS work on any viewing device, and with any distribution medium. CAPS is appropriate for viewing Internet streamed movies in 3-D.

  20. Subsea adjustable choke valves

    SciTech Connect

    Cyvas, M.K. )

    1989-08-01

    With emphasis on deepwater wells and marginal offshore fields growing, the search for reliable subsea production systems has become a high priority. A reliable subsea adjustable choke is essential to the realization of such a system, and recent advances are producing the degree of reliability required. Technological developments have been primarily in (1) trim material (including polycrystalline diamond), (2) trim configuration, (3) computer programs for trim sizing, (4) component materials, and (5) diver/remote-operated-vehicle (ROV) interfaces. These five facets are overviewed and progress to date is reported. A 15- to 20-year service life for adjustable subsea chokes is now a reality. Another factor vital to efficient use of these technological developments is to involve the choke manufacturer and ROV/diver personnel in initial system conceptualization. In this manner, maximum benefit can be derived from the latest technology. Major areas of development still required and under way are listed, and the paper closes with a tabulation of successful subsea choke installations in recent years.

  1. 77 FR 40387 - Price Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... Price Adjustment AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recently filed Postal Service request to adjust prices for several market dominant products... announcing its intent to adjust prices for several market dominant products within First-Class Mail...

  2. Properties of the Hubert-Arabie adjusted Rand index.

    PubMed

    Steinley, Douglas

    2004-09-01

    This article provides an investigation of cluster validation indices that relates 4 of the indices to the L. Hubert and P. Arabie (1985) adjusted Rand index--the cluster validation measure of choice (G. W. Milligan & M. C. Cooper, 1986). It is shown how these other indices can be "roughly" transformed into the same scale as the adjusted Rand index. Furthermore, in-depth explanations are given of why classification rates should not be used in cluster validation research. The article concludes by summarizing several properties of the adjusted Rand index across many conditions and provides a method for testing the significance of observed adjusted Rand indices. PMID:15355155

  3. Source tracing of fluvial suspended sediments by magnetic and geochemical particle characterization: example of the Canche watershed (Nord-Pas-de-Calais, France)

    NASA Astrophysics Data System (ADS)

    Patault, Edouard; Alary, Claire; Franke, Christine; Gauthier, Arnaud; Abriak, Nor-Edine

    2016-04-01

    In France, erosion by water run-off is estimated to 1.5 t ha‑1yr‑1 and can exceed 10 t ha‑1yr‑1 in large growing areas, such as the North of France (Nord-Pas-de-Calais). In this region, the Canche watershed (1294 km2) sustains heavy loss of fertile soils. The land use is mainly dominated by arable lands (80%) and in 2013, 104 kt of suspended sediment transited to the estuary. As demonstrated in literature, agricultural soil erosion leads to the gradual disappearance and depletion of fertile soil, which constitute a non-renewable resource at human time scale. Additionally, water erosion can significantly damage the aquatic habitat and can be responsible for the input of nutrients, bacteria, pesticides, heavy metals and radionuclides into surface waters. Conscious of these effects, many programs have emerged in the Nord-Pas-de-Calais to reduce erosion. This study presents a combination of environmental magnetic proxy parameters and geochemical analyses on sediments and suspended particulate matter. The aim is to develop effective tools to trace erosion by water run-off and quantify this process. In order to identify the respective sediment sources in the Canche watershed, sediment trap samples of suspended particulate matter were recovered at key positions along the Canche watershed. The preliminary results show that magnetic concentration (Mrs) shows typical values for the agricultural soils in the region, but these variations in magnetic concentrations and total irons concentrations are not always correlated, which may be explained by the iron speciation. In calculating the so-called S-ratio for each sample we can distinguish changes in magneto-mineralogy (and thus iron speciation) from magnetite-dominated assemblages in the mainstream Canche (naturel background signal) to high-coercivity-dominated assemblages in the tributaries, typical for soil erosion material rich in hematite/goethite. In combination with the element concentrations from ICP analyses

  4. Modeling the uptake of neutral organic chemicals on XAD passive air samplers under variable temperatures, external wind speeds and ambient air concentrations (PAS-SIM).

    PubMed

    Armitage, James M; Hayward, Stephen J; Wania, Frank

    2013-01-01

    The main objective of this study was to evaluate the performance and demonstrate the utility of a fugacity-based model of XAD passive air samplers (XAD-PAS) designed to simulate the uptake of neutral organic chemicals under variable temperatures, external wind speeds and ambient air concentrations. The model (PAS-SIM) simulates the transport of the chemical across the air-side boundary layer and within the sampler medium, which is segmented into a user-defined number of thin layers. Model performance was evaluated using data for polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) from a field calibration study (i.e., active and XAD-PAS data) conducted in Egbert, Ontario, Canada. With some exceptions, modeled PAS uptake curves are in good agreement with the empirical PAS data. The results are highly encouraging, given the uncertainty in the active air sampler data used as input and other uncertainties related to model parametrization (e.g., sampler-air partition coefficients, the influence of wind speed on sampling rates). The study supports the further development and evaluation of the PAS-SIM model as a diagnostic (e.g., to aid interpretation of calibration studies and monitoring data) and prognostic (e.g., to inform design of future passive air sampling campaigns) tool. PMID:24175752

  5. PAS-1, a protein affinity purified from Ascaris suum worms, maintains the ability to modulate the immune response to a bystander antigen.

    PubMed

    Oshiro, Telma M; Enobe, Cristina S; Araújo, Cláudia A; Macedo, Mahasti S; Macedo-Soares, Maria Fernanda

    2006-04-01

    Helminth infections and parasite components have potent immunomodulatory effects on a host's immune system. In the present study, we investigated the effect of PAS-1, a protein component of Ascaris suum adult worms recognized by a monoclonal antibody (MAIP-1), on humoral and cell-mediated responses to a bystander antigen (ovalbumin [OVA]). MAIP-1 recognized only one of the three polypeptide chains of PAS-1, but neutralized the suppressive effect of the whole worm extract on OVA-specific antibody production. PAS-1 inhibited antibody production against a T-cell-dependent, but not a T-cell-independent, antigen in a dose-dependent way. IgM, IgG1, IgG2b, and also IgE and anaphylactic IgG1 levels were downregulated. In addition, PAS-1 inhibited OVA-specific delayed type hypersensitivity reactions in the footpad of mice, showing a potent immunosuppressive activity on both Th1 and Th2 responses that seems to be mediated by the induction of large amounts of IL-10 and IL-4. Indeed, PAS-1-specific spleen cells secreted sevenfold more IL-10 and threefold more IL-4 than OVA-specific cells in response to in vitro restimulation with the respective antigens. In conclusion, we showed that PAS-1, a single protein component from A. suum, maintains all its immunosuppressive properties. PMID:16519731

  6. Changes in content of free, conjugated and bound polyamines and osmotic adjustment in adaptation of vetiver grass to water deficit.

    PubMed

    Zhou, Qiang; Yu, Bingjun

    2010-06-01

    Osmotic adjustment and alteration of polyamines (PAs) have been suggested to play roles in plant adaptation to water deficit/drought stress. In this study, the changes in cell intactness, photosynthesis, compatible solutes and PAs [including putrescine (Put), spermidine (Spd) and spermine (Spm) each in free, conjugated and bound forms] were investigated in leaves of vetiver grass exposed to different intensity of water deficit stress and subsequent rewatering. The results showed that, when vetiver grass was exposed to the moderate (20% and 40% PEG-6000 solutions) and severe (60% PEG solution) water deficit for 6days, the plant injury degree (expressed as the parameters of plant growth, cell membrane integrity, water relations and photosynthesis) increased and contents of free and conjugated Put decreased with the rise of PEG concentration. Under the moderate water deficit, the plants could survive by the reduced osmotic potential (psi(s)), increased free and conjugated Spd and Spm in leaves. After subsequent rewatering, the osmotic balance was re-established, most of the above investigated physiological parameters were fully or partly recovered to the control levels. However, it was not the case for the severely-stressed and rewatering plants. It indicates that, vetiver grass can cope well with the moderate water deficit/drought stress by using the strategies of osmotic adjustment and maintenance of total contents of free, conjugated and bound PAs in leaves. PMID:20363642

  7. Differential response to anodal tDCS and PAS is indicative of impaired focal LTP-like plasticity in schizophrenia.

    PubMed

    Strube, Wolfgang; Bunse, Tilmann; Nitsche, Michael A; Palm, Ulrich; Falkai, Peter; Hasan, Alkomiet

    2016-09-15

    Increasing evidence suggests that neural plasticity impairments, observed in schizophrenia patients, are driven by dysfunctional integration of neural signaling. However, what is less clear is whether this impairment is resultant from a general deficit in plastic induction or whether a specific plastic mechanism is affected. In the current study we aimed to assess whether schizophrenia has a selective impact on focal or non-focal plasticity induction. To pursue this goal we utilized two non-invasive stimulation techniques that differ in the mechanism of long-term potentiation (LTP)-like plasticity induction: focal paired associative stimulation (PAS) and non-focal anodal transcranial direct current stimulation (a-tDCS). 20 schizophrenia patients and 20 matched healthy controls received PAS and a-tDCS in two separate sessions. Cortical excitability and cortical plasticity were assessed by transcranial magnetic stimulation (TMS)-elicited motor evoked potentials (MEP). In both study groups, non-focal a-tDCS resulted in a significant increase of mean MEP magnitude indicating the successful induction of non-focal LTP-like plasticity. In contrast, an increase in mean MEP magnitude following PAS was only observed in the control group, suggesting impaired focal LTP-like plasticity in schizophrenia. Additionally, we observed significantly impaired short-latency intracortical inhibition (SICI) in schizophrenia. This is the first study to comparatively evaluate non-focal and focal plasticity mechanisms in schizophrenia patients. The differential patterns of LTP-like plasticity responses indicate that reduced plasticity in schizophrenia could be ascribed to impairments in spatially and temporally restricted signal integration. This impairment, coupled with an observed reduction of inhibitory circuit efficacy, might further contribute to impairments in coordinating focal signals. PMID:27185738

  8. Delay Adjusted Incidence Infographic

    Cancer.gov

    This Infographic shows the National Cancer Institute SEER Incidence Trends. The graphs show the Average Annual Percent Change (AAPC) 2002-2011. For Men, Thyroid: 5.3*,Liver & IBD: 3.6*, Melanoma: 2.3*, Kidney: 2.0*, Myeloma: 1.9*, Pancreas: 1.2*, Leukemia: 0.9*, Oral Cavity: 0.5, Non-Hodgkin Lymphoma: 0.3*, Esophagus: -0.1, Brain & ONS: -0.2*, Bladder: -0.6*, All Sites: -1.1*, Stomach: -1.7*, Larynx: -1.9*, Prostate: -2.1*, Lung & Bronchus: -2.4*, and Colon & Rectum: -3/0*. For Women, Thyroid: 5.8*, Liver & IBD: 2.9*, Myeloma: 1.8*, Kidney: 1.6*, Melanoma: 1.5, Corpus & Uterus: 1.3*, Pancreas: 1.1*, Leukemia: 0.6*, Brain & ONS: 0, Non-Hodgkin Lymphoma: -0.1, All Sites: -0.1, Breast: -0.3, Stomach: -0.7*, Oral Cavity: -0.7*, Bladder: -0.9*, Ovary: -0.9*, Lung & Bronchus: -1.0*, Cervix: -2.4*, and Colon & Rectum: -2.7*. * AAPC is significantly different from zero (p<.05). Rates were adjusted for reporting delay in the registry. www.cancer.gov Source: Special section of the Annual Report to the Nation on the Status of Cancer, 1975-2011.

  9. A gigapixel commercially manufactured cryogenic camera for the J-PAS 2.5m survey telescope

    NASA Astrophysics Data System (ADS)

    Jorden, P. R.; Bastable, M.; Clapp, M.; Darby, S.; Dryer, M.; Eaton, T.; Fenemore-Jones, G.; Jerram, P.; Marin-Franch, A.; Palmer, I.; Pittock, R.; Pool, P.; Rennshaw, R.; Taylor, K.; Waltham, N.; Wheeler, P.

    2012-07-01

    The J-PAS (Javalambre Physics-of-the-Accelerating-Universe Astrophysical Survey) project will perform a five-year survey of the northern sky from a new 2.5m telescope in Teruel, Spain. We describe the design concept of a complete cryogenic camera with a mosaic focal plane and 1.2 gigapixel science array which is to be commercially supplied. The focal plane is contained within a novel liquid-nitrogen-cooled vacuum cryostat, with proximity drive electronics designed to achieve a 4 e- readout noise from the 224-channel CCD system.

  10. [Interpersonal motivation in a First Year Experience class influences freshmen's university adjustment].

    PubMed

    Nakayama, Rumiko; Nakanishi, Yoshifumi; Nagahama, Fumiyo; Nakajima, Makoto

    2015-06-01

    The present study examined the influence of interpersonal motivation on university adjustment in freshman students enrolled in a First Year Experience (FYE) class. An interpersonal motivation scale and a university adjustment (interpersonal adjustment and academic adjustment) scale were administered twice to 116 FYE students; data from the 88 students who completed both surveys were analyzed. Results from structural equation modeling indicated a causal relationship between interpersonal, motivation and university adjustment: interpersonal adjustment served as a mediator between academic adjustment and interpersonal motivation, the latter of which was assessed using the internalized motivation subscale of the Interpersonal Motivation Scale as well as the Relative Autonomy Index, which measures the autonomy in students' interpersonal attitudes. Thus, revising the FYE class curriculum to include approaches to lowering students' feelings of obligation and/or anxiety in their interpersonal interactions might improve their adjustment to university. PMID:26182493

  11. Thermal Weapon Sight (TWS) AN/PAS-13 diffractive optics designed for producibility

    NASA Technical Reports Server (NTRS)

    Anderson, J. Steven; Chen, Chungte W.; Spande, Robert A.

    1993-01-01

    The Thermal Weapon Sight (TWS) program is a manportable 3-5 micrometer forward-looking-infrared (FLIR) rifle sight. The manportable nature requires that the optics modules be lightweight, low cost and compact while maximizing performance. These objectives were met with diffractive optics. TWS promises to be the first FLIR sensor to incorporate kinoform surfaces in full scale production.

  12. Characterization of npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system.

    PubMed

    Brunskill, E W; Witte, D P; Shreiner, A B; Potter, S S

    1999-11-01

    Here we describe the cloning and expression pattern of a new bHLH-PAS domain gene, Npas3. Npas3 shares 50.2% amino acid sequence identity with Npas1 and a lesser similarity with other members of the bHLH-PAS domain family of transcription factors. Northern blot analysis detected Npas3 mRNA between 11.5 and 17.5 d.p.c. in embryonic development and exclusively in the adult brain. Whole-mount and section in situ hybridization assays revealed expression of Npas3 between 9.5 and 11.5 d.p.c. in the developing neural tube. In addition, Npas3 mRNA was expressed throughout the neuroepithelium of the developing central nervous system between 10. 5 and 12.5 d.p.c. Interestingly, at 14.5 d.p.c., the expression of Npas3 mRNA became restricted to the neopallial layer of the cortex. At 12.5 d.p.c., Npas3 mRNA was evident in nonneural tissues such as the developing dermis and mesenchyme surrounding the otic and nasal placodes. Expression was also detected in the developing cardiac valves, limb and developing kidney. PMID:10534623

  13. 78 FR 62712 - Rate Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... Rate Adjustment AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing seeking postal rate adjustments based on exigent circumstances... On September 26, 2013, the Postal Service filed an exigent rate request with the Commission...

  14. Adjustable holder for transducer mounting

    NASA Technical Reports Server (NTRS)

    Deotsch, R. C.

    1980-01-01

    Positioning of acoustic sensor, strain gage, or similar transducer is facilitated by adjustable holder. Developed for installation on Space Shuttle, it includes springs for maintaining uniform load on transducer with adjustable threaded cap for precisely controlling position of sensor with respect to surrounding structure.

  15. Spousal Adjustment to Myocardial Infarction.

    ERIC Educational Resources Information Center

    Ziglar, Elisa J.

    This paper reviews the literature on the stresses and coping strategies of spouses of patients with myocardial infarction (MI). It attempts to identify specific problem areas of adjustment for the spouse and to explore the effects of spousal adjustment on patient recovery. Chapter one provides an overview of the importance in examining the…

  16. Mood Adjustment via Mass Communication.

    ERIC Educational Resources Information Center

    Knobloch, Silvia

    2003-01-01

    Proposes and experimentally tests mood adjustment approach, complementing mood management theory. Discusses how results regarding self-exposure across time show that patterns of popular music listening among a group of undergraduate students differ with initial mood and anticipation, lending support to mood adjustment hypotheses. Describes how…

  17. Bias Adjustment of PERSIANN Rainfall for Hydrologic Applications

    NASA Astrophysics Data System (ADS)

    Hsu, K.; Braithwaite, D.; Imam, B.; Gao, X.; Sorooshian, S.

    2008-05-01

    The exchange of water and energy through the land and atmospheric interaction occurs at various space and time scales. Modeling these exchanges, in general, and more specifically, adequate capturing of land surface hydrologic processes such as soil moisture and runoff generation requires reliable modeling and measurement of precipitation at fine time scale. The maturity of Satellite-based rainfall estimates is now sufficient to consider the value of such products in improving land surface models. This study addresses the measurement and bias correction of PERSIANN (Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks) rainfall to sub-daily scale of 0.25ox0.25o with emphasis on its potential use in land-surface hydrologic applications. The satellite-based PERSIANN system estimates surface rainfall based on infrared temperature and local image texture from geostationary satellites. Model parameters of PERSIANN are frequently adjusted when passive microwave rainfall estimates from low-orbital satellites (EOS, TRMM, NOAA, and DMSP) are available. PERSIANN estimates rainfall at hourly and 0.25ox0.25o lat-long scales. Its products are accumulated to daily and monthly scales for various applications. In this presentation, PERSIANN bias adjustment using monthly estimates from the Global Precipitation Climatology Project (GPCP) product is explored. Hourly PERSIANN rainfall estimates are first aggregated both spatially and temporally to the monthly 2.5ox2.5o scale and subsequently adjusted using GCPC monthly estimates as reference. Values of bias in PERSIANN are used to adjust PERSIANN rainfall at the 0.25ox0.25o hourly scale. The effectiveness of bias adjustment is evaluated using radar and gauge measurements at sub- daily to monthly scales at a spatial resolution of 0.25ox0.25o lat-long. The potential use of adjusted PERSIANN in hydrologic applications will be presented and discussed.

  18. Gain-of-function mutations cluster in distinct regions associated with the signalling pathway in the PAS domain of the aerotaxis receptor, Aer.

    PubMed

    Campbell, Asharie J; Watts, Kylie J; Johnson, Mark S; Taylor, Barry L

    2010-08-01

    The Aer receptor monitors internal energy (redox) levels in Escherichia coli with an FAD-containing PAS domain. Here, we randomly mutagenized the region encoding residues 14-119 of the PAS domain and found 72 aerotaxis-defective mutants, 24 of which were gain-of-function, signal-on mutants. The mutations were mapped onto an Aer homology model based on the structure of the PAS-FAD domain in NifL from Azotobacter vinlandii. Signal-on lesions clustered in the FAD binding pocket, the beta-scaffolding and in the N-cap loop. We suggest that the signal-on lesions mimic the 'signal-on' state of the PAS domain, and therefore may be markers for the signal-in and signal-out regions of this domain. We propose that the reduction of FAD rearranges the FAD binding pocket in a way that repositions the beta-scaffolding and the N-cap loop. The resulting conformational changes are likely to be conveyed directly to the HAMP domain, and on to the kinase control module. In support of this hypothesis, we demonstrated disulphide band formation between cysteines substituted at residues N98C or I114C in the PAS beta-scaffold and residue Q248C in the HAMP AS-2 helix. PMID:20545849

  19. The Relationship Between Self-Concept and Marital Adjustment for Commuter College Students

    ERIC Educational Resources Information Center

    Hall, William M.; Valine, Warren J.

    1977-01-01

    An investigation was made of the relationship between self-concept and the adjustment of commuter college students. Instruments used were the Tennessee Self Concept Scale and the Locke-Wallace Marital Adjustment Test. There was a significant relationship between self-concept and marital adjustment. (Author)

  20. Social Adjustment of College Freshmen: The Importance of Gender and Living Environment

    ERIC Educational Resources Information Center

    Enochs, Wendy K.; Roland, Catherine B.

    2006-01-01

    The relationship between living environment, gender and both overall adjustment to college and social adjustment in freshmen students was examined in this study. The College Adjustment Scales were administered to 511 freshmen students living in on-campus housing. There were 259 students living in Freshmen Year Experience (FYE) Halls verses 252…

  1. Marital Adjustment and Self-Actualization in Couples Married Before and After Spinal Cord Injury.

    ERIC Educational Resources Information Center

    Simmons, Stephen; Ball, Steven E.

    1984-01-01

    Compared personality and marital adjustment of 32 couples married before or after the husband's spinal cord injury. Subjects completed the Dyadic Adjustment Scale and Personal Orientation Inventory. Results showed couples married after the injury were more inner-directed and better adjusted than couples married before the injuries. (JAC)

  2. Prevalence, correlates, and costs of patients with poor adjustment to mixed cancers.

    PubMed

    Butler, Lorna; Downe-Wamboldt, Barbara; Melanson, Patricia; Coulter, Lynn; Keefe, Janice; Singleton, Jerome; Bell, David

    2006-01-01

    Approximately 2% to 3% of the Canadian society has experienced cancer. Literature indicates that there is poor adjustment to chronic illness. Individuals with poor adjustment to chronic illness have been found to disproportionately use more health services. The purpose of this study was to determine the prevalence, correlates, and costs associated with poor adjustment to mixed cancer. A consecutive sample (n = 171) of breast, lung, and prostate cancer patients at the Nova Scotia Regional Cancer Center were surveyed. Twenty-eight percent of the cancer group showed fair to poor adjustment to illness using the Psychological Adjustment to Illness Self-report Scale Psychological Adjustment to Illness Self-Report Scale raw score. Poor adjustment was moderately correlated with depression (r = 0.50, P < .0001) and evasive coping (r = 0.38, P < .0001) and unrelated to demographic variables. Depression explained 25% of the variance in poor adjustment to illness in regression analysis. Cancer patients with fair to poor adjustment to illness had statistically significantly higher annual healthcare expenditures (P < .002) than those with good adjustment to illness. Expenditure findings agree with previous literature on chronic illnesses. The prevalence of fair to poor adjustment in this cancer population using the Psychological Adjustment to Illness Self-Report Scale measure is similar to that reported for chronic illness to date, suggesting that only those with better adjustment consented to this study. PMID:16557115

  3. Modeling the Arabidopsis seed shape by a cardioid: efficacy of the adjustment with a scale change with factor equal to the Golden Ratio and analysis of seed shape in ethylene mutants.

    PubMed

    Cervantes, Emilio; Javier Martín, José; Ardanuy, Ramón; de Diego, Juana G; Tocino, Angel

    2010-03-15

    A new model for the description of Arabidopsis seed shape based on the comparison of the outline of its longitudinal section with a transformed cardioid is presented. The transformation consists of scaling the horizontal axis by a factor equal to the Golden Ratio. The elongated cardioid approximates the shape of the Arabidopsis seed with more accuracy than other figures. The length to width ratio in wild-type Columbia Arabidopsis dry seeds is close to the Golden Ratio and decreases over the course of imbibition. Dry seeds of etr1-1 mutants presented a reduced length to width ratio. Application of the new model based on the cardioid allows for comparison of shape between wild-type and mutant genotypes, revealing other general alterations in the seeds in ethylene signaling pathway mutants (etr1-1). PMID:19880215

  4. Using narrow-band J-PAS photometry to assess the properties of the stellar population in galaxies

    NASA Astrophysics Data System (ADS)

    Bruzual, Gustavo; Mejia-Narvaez, Alfredo; Magris C., Gladis

    2015-08-01

    We study the uncertainties and biases on the properties of the stellar population content of galaxies retrieved from narrow-band (J-PAS) photometry using the non-parametric method of spectral fitting dubbed DynBaS. We construct a star formation history library à la Chen et al. (2012), and then SED-fit a selection of synthetic spectra with observational properties similar to SDSS galaxies. We confront the results obtained from the photometric fits to those obtained from spectroscopic data for synthetic and real galaxies at various redshift ranges. Since no assumption on the star formation history is made, the so called template mismatch biases are naturally overcome. We find that biases in our estimations are the consequence of the several degeneracies between mass, age, metallicity, and internal dust extinction present in galaxy properties.

  5. [Translation and validation of the Revised Social Anhedonia Scale (SAS Social Anhedonia Scale, M.L. Eckblad, L.J. Chapman et al., 1982). Study of the internal and concurrent validity in 126 normal subjects].

    PubMed

    Kosmadakis, C S; Bungener, C; Pierson, A; Jouvent, R; Widlöcher, D

    1995-01-01

    The Revised Social Anhedonia Scale (SAS) with 40 items (Eckblad et al., 1982) which studies the social dimension of anhedonia has been validated in the United-States (Mishlove & Chapman, 1985). However, no french translation and validation of this scale has been made to date. This work presents the french translation of the Social Anhedonia Scale and its validation. After a back-translation and final adjustment, it has been submitted to a sample of 126 control subjects from the general population. Furthermore, they were asked to fill two other scales: the Chapman Physical Anhedonia (PAS) with 61 items and the Fawcett Pleasure Scale (36 items), both of them exploring the subjects answer in terms of anhedonia/hedonia towards social, sensorial and/or physical experiences. The internal validity has been determined on the one hand by the Cronbach alpha coefficient which showed a strong unidimensional characteristic (0.80) and the other hand by the correlation of each item with the total score using the point biserial coefficient which ranged from .204 to .559. The concurrent validation has been determined by the Pearson correlation coefficient between the french version of social anhedonia scale and the french version of physical anhedonia scale. The values were .42, p = .001. Furthermore, this two scales are significant inversely correled to the french version of the pleasure scale: r = -.22, p = .0125 for the first, and r = -.26, p = .0027 for the second. The internal and concurrent validity of the french version of the revised social anhedonia scale should allow to improve our understanding of anhedonia in psychiatry and psychopathology. PMID:8674468

  6. Uncertainty Assessment for Fast Reactors Based on Nuclear Data Adjustment

    NASA Astrophysics Data System (ADS)

    Ivanova, T.; Ivanov, E.; Ecrabet, F.

    2014-04-01

    The paper presents IRSN's results of the OECD/NEA WPEC Subgroup 33 benchmark exercise which is focused upon combined use of differential and integral data using adjustment technique. The results are generated by BERING code using different sets of input data: integral parameters and sensitivity coefficients for fast benchmark experiments and applications computed by deterministic ERANOS code and Monte Carlo SCALE sequences, COMMARA-2.0 and JENDL-4.0 cross-section-covariance data and integral correlations provided by JAEA. The paper demonstrates results of the adjustment when using different input data and two adjustment algorithms implemented in BERING.

  7. Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

    PubMed

    Semplici, Francesca; Vaxillaire, Martine; Fogarty, Sarah; Semache, Meriem; Bonnefond, Amélie; Fontés, Ghislaine; Philippe, Julien; Meur, Gargi; Diraison, Frederique; Sessions, Richard B; Rutter, Jared; Poitout, Vincent; Froguel, Philippe; Rutter, Guy A

    2011-12-23

    PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity. We aimed here to identify mutations in the PASK gene that may be associated with young-onset diabetes in humans. We screened 18 diabetic probands with unelucidated maturity-onset diabetes of the young (MODY). We identified two rare nonsynonymous mutations in the PASK gene (p.L1051V and p.G1117E), each of which was found in a single MODY family. Wild type or mutant PASKs were expressed in HEK 293 cells. Kinase activity of the affinity-purified proteins was assayed as autophosphorylation at amino acid Thr307 or against an Ugp1p-derived peptide. Whereas the PASK p.G1117E mutant displayed a ∼25% increase with respect to wild type PASK in the extent of autophosphorylation, and a ∼2-fold increase in kinase activity toward exogenous substrates, the activity of the p.L1051V mutant was unchanged. Amino acid Gly1117 is located in an α helical region opposing the active site of PASK and may elicit either: (a) a conformational change that increases catalytic efficiency or (b) a diminished inhibitory interaction with the PAS domain. Mouse islets were therefore infected with adenoviruses expressing wild type or mutant PASK and the regulation of insulin secretion was examined. PASK p.G1117E-infected islets displayed a 4-fold decrease in glucose-stimulated (16.7 versus 3 mM) insulin secretion, chiefly reflecting a 4.5-fold increase in insulin release at low glucose. In summary, we have characterized a rare mutation (p.G1117E) in the PASK gene from a young-onset diabetes family, which modulates glucose-stimulated insulin secretion. PMID:22065581

  8. H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein

    PubMed Central

    Valladares, Ricardo B.; Graves, Christina; Wright, Kaitlyn; Gardner, Christopher L.; Lorca, Graciela L.; Gonzalez, Claudio F.

    2015-01-01

    Host and commensals crosstalk, mediated by reactive oxygen species (ROS), has triggered a growing scientific interest to understand the mechanisms governing such interaction. However, the majority of the scientific studies published do not evaluate the ROS production by commensals bacteria. In this context we recently showed that Lactobacillus johnsonii N6.2, a strain of probiotic value, modulates the activity of the critical enzymes 2,3-indoleamine dioxygenase via H2O2 production. L. johnsonii N6.2 by decreasing IDO activity, is able to modify the tryptophan/kynurenine ratio in the host blood with further systemic consequences. Understanding the mechanisms of H2O2 production is critical to predict the probiotic value of these strains and to optimize bacterial biomass production in industrial processes. We performed a transcriptome analysis to identify genes differentially expressed in L. johnsonii N6.2 cells collected from cultures grown under different aeration conditions. Herein we described the biochemical characteristics of a heterodimeric FMN reductase (FRedA/B) whose in vitro activity is controlled by LjPAS protein with a typical Per-Arnst-Sim (PAS) sensor domain. Interestingly, LjPAS is fused to the FMN reductase domains in other lactobacillaceae. In L. johnsonii, LjPAS is encoded by an independent gene which expression is repressed under anaerobic conditions (>3 fold). Purified LjPAS was able to slow down the FRedA/B initial activity rate when the holoenzyme precursors (FredA, FredB, and FMN) were mixed in vitro. Altogether the results obtained suggest that LjPAS module regulates the H2O2 production helping the cells to minimize oxidative stress in response to environmental conditions. PMID:26236298

  9. Adjustable Induction-Heating Coil

    NASA Technical Reports Server (NTRS)

    Ellis, Rod; Bartolotta, Paul

    1990-01-01

    Improved design for induction-heating work coil facilitates optimization of heating in different metal specimens. Three segments adjusted independently to obtain desired distribution of temperature. Reduces time needed to achieve required temperature profiles.

  10. Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation

    PubMed Central

    Corrada, Dario; Soshilov, Anatoly A.; Denison, Michael S.

    2016-01-01

    The Aryl hydrocarbon Receptor (AhR) is a transcription factor that mediates the biochemical response to xenobiotics and the toxic effects of a number of environmental contaminants, including dioxins. Recently, endogenous regulatory roles for the AhR in normal physiology and development have also been reported, thus extending the interest in understanding its molecular mechanisms of activation. Since dimerization with the AhR Nuclear Translocator (ARNT) protein, occurring through the Helix-Loop-Helix (HLH) and PER-ARNT-SIM (PAS) domains, is needed to convert the AhR into its transcriptionally active form, deciphering the AhR:ARNT dimerization mode would provide insights into the mechanisms of AhR transformation. Here we present homology models of the murine AhR:ARNT PAS domain dimer developed using recently available X-ray structures of other bHLH-PAS protein dimers. Due to the different reciprocal orientation and interaction surfaces in the different template dimers, two alternative models were developed for both the PAS-A and PAS-B dimers and they were characterized by combining a number of computational evaluations. Both well-established hot spot prediction methods and new approaches to analyze individual residue and residue-pairwise contributions to the MM-GBSA binding free energies were adopted to predict residues critical for dimer stabilization. On this basis, a mutagenesis strategy for both the murine AhR and ARNT proteins was designed and ligand-dependent DNA binding ability of the AhR:ARNT heterodimer mutants was evaluated. While functional analysis disfavored the HIF2α:ARNT heterodimer-based PAS-B model, most mutants derived from the CLOCK:BMAL1-based AhR:ARNT dimer models of both the PAS-A and the PAS-B dramatically decreased the levels of DNA binding, suggesting this latter model as the most suitable for describing AhR:ARNT dimerization. These novel results open new research directions focused at elucidating basic molecular mechanisms underlying the

  11. Preschool Children's School Adjustment: Indicators of Behaviour Problems, Gender, and Peer Victimisation

    ERIC Educational Resources Information Center

    Yoleri, Sibel

    2015-01-01

    The relationships among school adjustment, victimisation, and gender were investigated with 284 Turkish children aged between five and six years. Teacher Rating Scale of School Adjustment, The Preschool Behaviour Questionnaire, and Peer Victimisation Scale were used in this study. Analyses indicated that children's behaviour problems and…

  12. 7 CFR 251.7 - Formula adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Formula adjustments. 251.7 Section 251.7 Agriculture... GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION THE EMERGENCY FOOD ASSISTANCE PROGRAM § 251.7 Formula adjustments. Formula adjustments. (a) Commodity adjustments. The Department will make annual adjustments...

  13. 12 CFR 1209.80 - Inflation adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Inflation adjustments. 1209.80 Section 1209.80... PROCEDURE Civil Money Penalty Inflation Adjustments § 1209.80 Inflation adjustments. The maximum amount of... thereafter adjusted in accordance with the Inflation Adjustment Act, on a recurring four-year cycle, is...

  14. 12 CFR 1209.80 - Inflation adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Inflation adjustments. 1209.80 Section 1209.80... PROCEDURE Civil Money Penalty Inflation Adjustments § 1209.80 Inflation adjustments. The maximum amount of... thereafter adjusted in accordance with the Inflation Adjustment Act, on a recurring four-year cycle, is...

  15. 12 CFR 1209.80 - Inflation adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Inflation adjustments. 1209.80 Section 1209.80... PROCEDURE Civil Money Penalty Inflation Adjustments § 1209.80 Inflation adjustments. The maximum amount of... thereafter adjusted in accordance with the Inflation Adjustment Act, on a recurring four-year cycle, is...

  16. Fitts’ Law in Early Postural Adjustments

    PubMed Central

    Bertucco, M.; Cesari, P.; Latash, M.L

    2012-01-01

    We tested a hypothesis that the classical relation between movement time and index of difficulty (ID) in quick pointing action (Fitts’ Law) reflects processes at the level of motor planning. Healthy subjects stood on a force platform and performed quick and accurate hand movements into targets of different size located at two distances. The movements were associated with early postural adjustments that are assumed to reflect motor planning processes. The short distance did not require trunk rotation, while the long distance did. As a result, movements over the long distance were associated with substantiual Coriolis forces. Movement kinematics and contact forces and moments recorded by the platform were studied. Movement time scaled with ID for both movements. However, the data could not be fitted with a single regression: Movements over the long distance had a larger intercept corresponding to movement times about 140 ms longer than movements over the shorter distance. The magnitude of postural adjustments prior to movement initiation scaled with ID for both short and long distances. Our results provide strong support for the hypothesis that Fitts’ Law emerges at the level of motor planning, not at the level of corrections of ongoing movements. They show that, during natural movements, changes in movement distance may lead to changes in the relation between movement time and ID, for example when the contribution of different body segments to the movement varies and when the action of Coriolis force may require an additional correction of the movement trajectory. PMID:23211560

  17. Extinction, seeing and sky transparency monitoring at the Observatorio Astrofísico de Javalambre for J-PAS and J-PLUS calibration and scheduling

    NASA Astrophysics Data System (ADS)

    Vázquez Ramió, H.; Díaz-Martín, M. C.; Varela, J.; Ederoclite, A.; Maícas, N. Lamadrid, J. L.; Abril, J.; Iglesias-Marzoa, R.; Rodríguez, S.; Tilve, V.; Cenarro, A. J.; Antón Bravo, J. L.; Bello Ferrer, R.; Cristóbal-Hornillos, D.; Guillén Civera, L.; Hernández-Fuertes, J.; Jiménez Mejías, D.; Lasso-Cabrera, N. M.; López Alegre, G.; López Sainz, A.; Luis-Simoes, R. M.; Marín-Franch, A.; Moles, M.; Rueda-Teruel, F.; Rueda-Teruel, S.; Suárez López, O.; Yanes-Díaz, A.

    2015-05-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS; see Benítez et al. 2014) and the Javalambre-Photometric Local Universe Survey (J-PLUS) will be conducted at the brand-new Observatorio Astrofísico de Javalambre (OAJ) in Teruel, Spain. J-PLUS is planned to start by the first half of 2015 while J-PAS first light is expected to happen along 2015. Besides the two main telescopes (with 2.5 m and 80 cm apertures), several smaller-sized facilities are present at the OAJ devoted to site characterization and supporting measurements to be used to calibrate the J-PAS and J-PLUS photometry and to feed up the OAJ's Sequencer with the integrated seeing and the sky transparency. These instruments are: i) an extinction monitor, an 11 " telescope estimating the atmospheric extinction to finally obtain the OAJ extinction curve, which is the initial step to J-PAS overall photometric calibration procedure; ii) an 8 " telescope implementing the Differential Image Motion Monitor (DIMM) technique to obtain the integrated seeing; and iii) an All-Sky Transmission MONitor (ASTMON), a roughly all-sky instrument providing the sky transparency as well as sky brightness and the atmospheric extinction too.

  18. An Investigation of Interrater Reliability for the Rorschach Performance Assessment System (R-PAS) in a Nonpatient U.S. Sample.

    PubMed

    Kivisalu, Trisha M; Lewey, Jennifer H; Shaffer, Thomas W; Canfield, Merle L

    2016-01-01

    The Rorschach Performance Assessment System (R-PAS) aims to provide an evidence-based approach to administration, coding, and interpretation of the Rorschach Inkblot Method (RIM). R-PAS analyzes individualized communications given by respondents to each card to code a wide pool of possible variables. Due to the large number of possible codes that can be assigned to these responses, it is important to consider the concordance rates among different assessors. This study investigated interrater reliability for R-PAS protocols. Data were analyzed from a nonpatient convenience sample of 50 participants who were recruited through networking, local marketing, and advertising efforts from January 2013 through October 2014. Blind recoding was used and discrepancies between the initial and blind coders' ratings were analyzed for each variable with SPSS yielding percent agreement and intraclass correlation values. Data for Location, Space, Contents, Synthesis, Vague, Pairs, Form Quality, Populars, Determinants, and Cognitive and Thematic codes are presented. Rates of agreement for 1,168 responses were higher for more simplistic coding (e.g., Location), whereas agreement was lower for more complex codes (e.g., Cognitive and Thematic codes). Overall, concordance rates achieved good to excellent agreement. Results suggest R-PAS is an effective method with high interrater reliability supporting its empirical basis. PMID:26730817

  19. Crystal structures of the F and pSLT plasmid TraJ N-terminal regions reveal similar homodimeric PAS folds with functional interchangeability

    SciTech Connect

    Lu, Jun; Wu, Ruiying; Adkins, Joshua N.; Joachimiak, Andrzej; Glover, Mark

    2014-09-16

    In the F-family of conjugative plasmids, TraJ is an essential transcriptional activator of the tra operon that encodes most of the proteins required for conjugation. Here we report for the first time the X-ray crystal structures of the TraJ N-terminal regions from the prototypic F plasmid (TraJF11-130) and from the Salmonella virulence plasmid pSLT (TraJpSLT 1-128). Both proteins form similar homodimeric Per-ARNT-Sim (PAS) fold structures. Mutational analysis reveals that the observed dimeric interface is critical for TraJF transcriptional activation, indicating that dimerization of TraJ is required for its in vivo function. An artificial ligand (oxidized dithiothreitol) occupies a cavity in the TraJF dimer interface, while a smaller cavity in corresponding region of the TraJpSLT structure lacks a ligand. Gas chromatography/mass spectrometry-electron ionization analysis of dithiothreitol-free TraJF suggests indole may be the natural TraJ ligand; however, disruption of the indole biosynthetic pathway does not affect TraJF function. Heterologous PAS domains from pSLT and R100 TraJ can functionally replace the TraJF PAS domain, suggesting that TraJ allelic specificity is mediated by the region C-terminal to the PAS domain.

  20. Psychometric Evaluation of a Dutch Version of the Mini PAS-ADD for Assessing Psychiatric Disorders in Adults with Different Levels of Intellectual Disability

    ERIC Educational Resources Information Center

    Janssen, R.; Maes, B.

    2013-01-01

    Background: People with intellectual disabilities (ID) have an increased vulnerability to develop psychiatric problems. Moreover, the early recognition and the accurate diagnosis of psychiatric disorders in the population of persons with ID are challenging. Method: A Dutch version of the Mini PAS-ADD, which is a screening instrument for…

  1. Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.

    PubMed

    Ooe, Norihisa; Saito, Koichi; Mikami, Nobuyoshi; Nakatuka, Iwao; Kaneko, Hideo

    2004-01-01

    Sim2, a basic helix-loop-helix (bHLH)-PAS transcriptional repressor, is thought to be involved in some symptoms of Down's syndrome. In the course of searching for hypothetical Sim2 relatives, we isolated another bHLH-PAS factor, NXF. NXF was a novel gene and was selectively expressed in neuronal tissues. While no striking homolog of NXF was found in vertebrates, a Caenorhabditis elegans putative transcription factor, C15C8.2, showed similarity in the bHLH-PAS domain. NXF had an activation domain as a transcription activator, and Arnt-type bHLH-PAS subfamily members were identified as the heterodimer partners of NXF. The NXF/Arnt heterodimer was capable of binding and activating a subset of Sim2/Arnt target DNA variants, and Sim2 could compete with the NXF activity on the elements. We showed that Drebrin had several such NXF/Arnt binding elements on the promoter, which could be direct or indirect cross talking points between NXF (activation) and Sim2 (repression) action. Drebrin has been reported to be engaged in dendritic-cytoskeleton modulation at synapses, and such a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 in the mental retardation of Down's syndrome. PMID:14701734

  2. Executive functions, depressive symptoms, and college adjustment in women.

    PubMed

    Wingo, Jana; Kalkut, Erica; Tuminello, Elizabeth; Asconape, Josefina; Han, S Duke

    2013-01-01

    Many students have difficulty adjusting to college, and the contribution of academic and relational factors have been considered in previous research. In particular, depression commonly emerges among college women at this time and could be related to poor adjustment to college. This study examined the relationship between executive functions, depressive symptoms, and college adjustment in college women. Seventy-seven female participants from a midsize urban university completed the Wechsler Abbreviated Scale of Intelligence, College Adjustment Scale, Beck Depression Inventory-Second Edition, Behavior Rating Inventory of Executive Function-Adult Version, and four subtests from the Delis-Kaplan Executive Function System: the Trail-Making Test, Design Fluency Test, Verbal Fluency Test, and Color-Word Interference Test. After controlling for IQ score, hierarchical regression analyses showed that subjective and objective measures of executive functioning and depressive symptoms were significantly related to college adjustment problems in academic, relational, and psychological areas. The current study provides evidence for a relationship between cognitive abilities, psychiatric symptoms, and college adjustment. PMID:23397999

  3. Final RQ adjustments rule issued

    SciTech Connect

    Bergeson, L.L.

    1995-08-01

    On June 12, 1995, the US Environmental Protection Agency (EPA) issued its long awaited final rule adjusting certain reportable quantities (RQs) for hazardous substances under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The rule: revises the table of hazardous substances to add 47 individual Clean Air Act (CAA) hazardous air pollutants (HAPs); adjustments their statutory one-pound RQs; adds five other CAA HAPs that are categories of substances and assigns no RQ to the categories; and adjusts RQs for 11 Resource Conservation and Recovery Act (RCRA) listed hazardous wastes. EPA made conforming changes to the Clean Water Act table of hazardous substances and the Emergency Planning and Community Right-to-Know Act (EPCRA) table of extremely hazardous substances. The rule became effective July 12, 1995.

  4. MCCB warm adjustment testing concept

    NASA Astrophysics Data System (ADS)

    Erdei, Z.; Horgos, M.; Grib, A.; Preradović, D. M.; Rodic, V.

    2016-08-01

    This paper presents an experimental investigation in to operating of thermal protection device behavior from an MCCB (Molded Case Circuit Breaker). One of the main functions of the circuit breaker is to assure protection for the circuits where mounted in for possible overloads of the circuit. The tripping mechanism for the overload protection is based on a bimetal movement during a specific time frame. This movement needs to be controlled and as a solution to control this movement we choose the warm adjustment concept. This concept is meant to improve process capability control and final output. The warm adjustment device design will create a unique adjustment of the bimetal position for each individual breaker, determined when the testing current will flow thru a phase which needs to trip in a certain amount of time. This time is predetermined due to scientific calculation for all standard types of amperages and complies with the IEC 60497 standard requirements.

  5. [Causal relationship between assertiveness and adjustment in children: A short-term longitudinal study].

    PubMed

    Eguchi, Megumi; Hamaguchi, Yoshikazu

    2015-08-01

    This study examined the causal relationships between assertiveness and both internal and external adjustment in children. Elementary school children in grades four through six (N = 284) participated in the study, which used a short-term longitudinal design. The children completed questionnaires twice during a 6-months period. They responded to assertiveness questionnaires that included two components: "self-expression" and "consideration of others". They also completed a self-esteem scale as an index of internal adjustment, and the Class Life Satisfaction scale as an index of external adjustment. There was a positive causative relationship between "self-expression" and internal adjustment and between "consideration for others" and external adjustment. In addition, the effects on adjustment varied according to the type of assertiveness. Cluster analysis and MANOVA indicated that the group with high "self-expression" and "consideration for others" had high internal and external adjustment, while the children with poor assertiveness showed the lowest degree of adaptivity. PMID:26402950

  6. Adjustable spacer with rotational lock

    SciTech Connect

    Bowyer, M.L.

    1984-02-28

    A spacing apparatus for tubing conduit in a subterranean well, normally for use with an electric component with a longitudinally extending external electrical cable, permits irrotational adjustment of the length of the tubing conduit. The spacing apparatus comprises telescoping members which are keyed to prevent rotation therebetween. A threaded member, longitudinally fixed relative to one longitudinal member, normally engages threads extending substantially along the entire length of the other telescoping member. Movement of a retaining sleeve permits disengagement of the threaded segments which ratchet along the threads during telescoping movement. The length of the conduit can thus be irrotationally adjusted to remove slack from the electrical cable.

  7. 75 FR 33379 - Railroad Cost Recovery Procedures-Productivity Adjustment; Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment; Quarterly Rail... Railroads that the Board restate the previously published productivity adjustment for the 2003-2007 averaging period (2007 productivity adjustment) so that it tracks the 2007 productivity adjustment...

  8. Differences in Memory Development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl Mice after Delay and Trace Fear Conditioning

    PubMed Central

    March, Amelia; Borchelt, David; Golde, Todd; Janus, Christopher

    2014-01-01

    Fear-conditioning testing paradigms have been used to study differences in memory formation between inbred mouse strains, including numerous mouse models of human diseases. In this study, we characterized the conditioned fear memory of 3 inbred strains: C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl, obtained from Charles River Laboratories. We used 2 training paradigms: delay conditioning, in which an unconditional stimulus coterminates with the presentation of a conditional stimulus, and trace conditioning, in which the conditional and unconditional stimuli are separated by a trace interval. In each paradigm, we evaluated the recent (3 d) and remote (25 d) memory of the mice by using a longitudinal design. Our results showed that both C57BL/6NCrl and 129S2/SvPasCrl mice developed strong and long-lasting context and tone memories in both paradigms, but FVB/NCrl mice showed a weaker but nevertheless consistent tone memory after delay training. Tone memory in the FVB strain was stronger in male than female mice. The remote tone memory of 129S2/SvPasCrl mice diminished after delay training but was stable and stronger than that of C57BL/6NCrl mice after trace training. In conclusion, both C57BL/6NCrl and 129S2/SvPasCrl mice showed reliable and long-lasting fear memory after delay or trace training, with 129 mice showing particularly strong tone memory after trace conditioning. The FVB/NCrl strain, especially male mice, showed reliable tone fear memory after delay training. Our findings confirm that both C57BL/6NCrl and 129S2/SvPasCrl mice develop strong context and tone memory in delay and trace fear-conditioning paradigms. PMID:24672832

  9. Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning.

    PubMed

    March, Amelia; Borchelt, David; Golde, Todd; Janus, Christopher

    2014-02-01

    Fear-conditioning testing paradigms have been used to study differences in memory formation between inbred mouse strains, including numerous mouse models of human diseases. In this study, we characterized the conditioned fear memory of 3 inbred strains: C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl, obtained from Charles River Laboratories. We used 2 training paradigms: delay conditioning, in which an unconditional stimulus coterminates with the presentation of a conditional stimulus, and trace conditioning, in which the conditional and unconditional stimuli are separated by a trace interval. In each paradigm, we evaluated the recent (3 d) and remote (25 d) memory of the mice by using a longitudinal design. Our results showed that both C57BL/6NCrl and 129S2/SvPasCrl mice developed strong and long-lasting context and tone memories in both paradigms, but FVB/NCrl mice showed a weaker but nevertheless consistent tone memory after delay training. Tone memory in the FVB strain was stronger in male than female mice. The remote tone memory of 129S2/SvPasCrl mice diminished after delay training but was stable and stronger than that of C57BL/6NCrl mice after trace training. In conclusion, both C57BL/6NCrl and 129S2/SvPasCrl mice showed reliable and long-lasting fear memory after delay or trace training, with 129 mice showing particularly strong tone memory after trace conditioning. The FVB/NCrl strain, especially male mice, showed reliable tone fear memory after delay training. Our findings confirm that both C57BL/6NCrl and 129S2/SvPasCrl mice develop strong context and tone memory in delay and trace fear-conditioning paradigms. PMID:24672832

  10. Cascaded solar photovoltaic cells based on InP-GaInPAs and InP-CdS heterostructures

    SciTech Connect

    Allakhverdiyev, A.M.; Andreyev, V.; Guseynov, I.A.; Iventyeva, O.O.; Ismailov, V.I.

    1984-08-01

    Cascaded solar cells with different widths of the forbidden band narrow band and wide band were studied. The narrow band cell was based on nInP-n(p)GaInPAs-pInP structure, and the wide band cell was based on pInP-nCdS heterostructure with similar lattice parameters of the contacting materials. The narrow band cells were made by liquid phase epitaxy, and the wide band cells were made by gas transport precipitation of CdS. The spectral characteristics show the feasibility of expanding the region of photosensitivity by using the principle of cascaded conversion of solar energy. The cell with pn junction in Ga0.5In0.75As0.85P0.42 utilizes light with photon energies of less than 1.35 eV that have passed without absorption through the covering photocell. The longwave limits of photosensitivity are determined by the width of the forbidden band of the active region of the corresponding photocells. The shortwave end of the spectrum is stretched out as a result of the low surface recombination rate.

  11. Fault activity in the epicentral area of the 1580 Dover Strait (Pas-de-Calais) earthquake (northwestern Europe)

    NASA Astrophysics Data System (ADS)

    García-Moreno, D.; Verbeeck, K.; Camelbeeck, T.; De Batist, M.; Oggioni, F.; Zurita Hurtado, O.; Versteeg, W.; Jomard, H.; Collier, J. S.; Gupta, S.; Trentesaux, A.; Vanneste, K.

    2015-05-01

    On 1580 April 6 one of the most destructive earthquakes of northwestern Europe took place in the Dover Strait (Pas de Calais). The epicentre of this seismic event, the magnitude of which is estimated to have been about 6.0, has been located in the offshore continuation of the North Artois shear zone, a major Variscan tectonic structure that traverses the Dover Strait. The location of this and two other moderate magnitude historical earthquakes in the Dover Strait suggests that the North Artois shear zone or some of its fault segments may be presently active. In order to investigate the possible fault activity in the epicentral area of the AD 1580 earthquake, we have gathered a large set of bathymetric and seismic-reflection data covering the almost-entire width of the Dover Strait. These data have revealed a broad structural zone comprising several subparallel WNW-ESE trending faults and folds, some of them significantly offsetting the Cretaceous bedrock. The geophysical investigation has also shown some indication of possible Quaternary fault activity. However, this activity only appears to have affected the lowermost layers of the sediment infilling Middle Pleistocene palaeobasins. This indicates that, if these faults have been active since Middle Pleistocene, their slip rates must have been very low. Hence, the AD 1580 earthquake appears to be a very infrequent event in the Dover Strait, representing a good example of the moderate magnitude earthquakes that sometimes occur in plate interiors on faults with unknown historical seismicity.

  12. The necessity of sample quality assessment in 14C AMS dating: The case of Cova des Pas (Menorca - Spain)

    NASA Astrophysics Data System (ADS)

    Van Strydonck, Mark; Boudin, Mathieu; Guerrero Ayuso, Víctor M.; Calvo, Manuel; Fullola, Josep M.; Àngeles Petit, M.

    2010-04-01

    The Cova des Pas cave is a karstic cave in the cliffs of the Barranc (canyon) de Trebalúger. It is a small cave only 6.5 m deep, 4.5 m wide and 1.7 m high. Yet more than 70 burials, in foetal position, from the Early Iron Age were found in this small cave. The conservation of the archaeological remains was very unusual. Not only wood, ropes and other plant material was found, but also remains of body tissue, hair and leather. In spite of the remarkable preservation of the bodies and artefacts, the state of conservation of the bone material was very bad. The bones contained little and heavily deteriorated collagen and the organic plant material was very fragile. The special environmental conditions of the cave are the cause of these unusual preservation conditions. Although the cave is situated in a limestone cliff, the soil of the cave is very acid. Unexpectedly bad sample quality seemed to be the major drawback for AMS radiocarbon dating on hair, wood, ropes and bone collagen, as well as on bio-apatite.

  13. Visual adjustments to temporal blur

    NASA Astrophysics Data System (ADS)

    Bilson, Aaron C.; Mizokami, Yoko; Webster, Michael A.

    2005-10-01

    After observers have adapted to an edge that is spatially blurred or sharpened, a focused edge appears too sharp or blurred, respectively. These adjustments to blur may play an important role in calibrating spatial sensitivity. We examined whether similar adjustments influence the perception of temporal edges, by measuring the appearance of a step change in the luminance of a uniform field after adapting to blurred or sharpened transitions. Stimuli were square-wave alternations (at 1 to 8 Hz) filtered by changing the slope of the amplitude spectrum. A two-alternative-forced-choice task was used to adjust the slope until it appeared as a step change, or until it matched the perceived transitions in a reference stimulus. Observers could accurately set the waveform to a square wave, but only at the slower alternation rates. However, these settings were strongly biased by prior adaptation to filtered stimuli, or when the stimuli were viewed within temporally filtered surrounds. Control experiments suggest that the latter induction effects result directly from the temporal blur and are not simply a consequence of brightness induction in the fields. These results suggest that adaptation and induction adjust visual coding so that images are focused not only in space but also in time.

  14. Self-Adjusting Fluency Therapy.

    ERIC Educational Resources Information Center

    Schneider, Phillip

    1998-01-01

    Presents a rationale and methodology for a self-adjusting "fluency sensitive" approach to working with children who exhibit overt speech-fluency interruptions and a minimal amount of avoidance behavior. The approach emphasizes repeated experiences of volitional increases and decreases in loudness and pauses. Case examples demonstrate how several…

  15. Adjustable Walker for the Handicapped

    NASA Technical Reports Server (NTRS)

    Kitts, R. G.

    1984-01-01

    Front legs adjust at touch of lever for use on stairs or ramps. Spring loaded legs extend when lever is depressed by user. Legs lock in position when lever is released. Lever mounted on either side of walker or on both sides, so legs operated independently.

  16. Adjustable Optical-Fiber Attenuator

    NASA Technical Reports Server (NTRS)

    Buzzetti, Mike F.

    1994-01-01

    Adjustable fiber-optic attenuator utilizes bending loss to reduce strength of light transmitted along it. Attenuator functions without introducing measurable back-reflection or insertion loss. Relatively insensitive to vibration and changes in temperature. Potential applications include cable television, telephone networks, other signal-distribution networks, and laboratory instrumentation.

  17. Adjustable-Angle Drill Block

    NASA Technical Reports Server (NTRS)

    Gallimore, F. H.

    1986-01-01

    Adjustable angular drill block accurately transfers hole patterns from mating surfaces not normal to each other. Block applicable to transfer of nonperpendicular holes in mating contoured assemblies in aircraft industry. Also useful in general manufacturing to transfer mating installation holes to irregular and angular surfaces.

  18. Economic Pressures and Family Adjustment.

    ERIC Educational Resources Information Center

    Haccoun, Dorothy Markiewicz; Ledingham, Jane E.

    The relationships between economic stress on the family and child and parental adjustment were examined for a sample of 199 girls and boys in grades one, four, and seven. These associations were examined separately for families in which both parents were present and in which mothers only were at home. Economic stress was associated with boys'…

  19. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes.

    PubMed Central

    Marzioch, M; Erdmann, R; Veenhuis, M; Kunau, W H

    1994-01-01

    To identify components of the peroxisomal import pathway in yeast, we have isolated pas mutants affected in peroxisome biogenesis. Two mutants assigned to complementation group 7 define a new gene, PAS7, whose product is necessary for import of thiolase, a PTS2-containing protein, but not for that of SKL (PTS1)-containing proteins, into peroxisomes. We have cloned PAS7 by complementation of the oleic acid non-utilizing phenotype of the pas7-1 strain. The DNA sequence predicts a 42.3 kDa polypeptide of 375 amino acids encoding a novel member of the beta-transducin related (WD-40) protein family. A Myc epitope-tagged Pas7p, expressed under the control of the CUP1 promotor, was functionally active. Subcellular localization studies revealed that in the presence of thiolase this epitope-tagged Pas7p in part associates with peroxisomes. However, in a thiolase-deficient mutant, Pas7p was entirely found in the cytoplasm. We suggest that Pas7p mediates the binding of thiolase to these organelles. Images PMID:7957058

  20. Data on schizotypy and affective scales are gender and education dependent--study in the Northern Finland 1966 Birth Cohort.

    PubMed

    Miettunen, Jouko; Veijola, Juha; Freimer, Nelson; Lichtermann, Dirk; Peltonen, Leena; Paunio, Tiina; Isohanni, Matti; Joukamaa, Matti; Ekelund, Jesper

    2010-07-30

    We present psychometric properties and normative data by gender and educational level in scales related to schizotypy and affective disorders in a large population-based adult sample. As part of the 31-year follow-up survey of the Northern Finland 1966 Birth Cohort; Bipolar II scale (BIP2), Hypomanic Personality Scale (HPS), Physical Anhedonia Scale (PAS), Social Anhedonia Scale (SAS), Perceptual Aberration Scale (PER) and Schizoidia Scale (SCHD) were filled in by 4928 subjects. In total sample mean scores were: BIP2 10.59 (3.80), HPS 11.26 (7.03), PAS 14.99 (S.D. 7.03), SAS 9.44 (5.52), PER 2.35 (3.26) and SCHD 2.56 (1.42). Men scored higher (had more psychopathological symptoms) in PAS and SAS (P<0.001), and in BIP2 (P=0.02). Women had higher scores in SCHD, HPS and PER (P<0.001). Participants with a lower level of education scored higher in all scales; differences were largest in BIP2, PAS and SAS (ES>0.5,P<0.001). The gender and education differences were moderate or large in all the included scales. These differences should be taken into account when considering normal values in these scales. The findings indicate that commonly used student samples are likely to be biased when compared to community based samples. PMID:20478630

  1. Psychological Adjustment and Neuropsychological Performance in Diabetic Patients.

    ERIC Educational Resources Information Center

    Skenazy, Judy A.; Bigler, Erin D.

    1985-01-01

    Compared diabetic (N=39) with nondiabetic chronic illness patients (N=20) and healthy controls (N=24). The chronic illness and the diabetic groups had significant elevations on the Hypochondriasis, Depression, and Hysteria scales of the Feschingbauer Abbreviated MMPI. For diabetics, results demonstrated a negligible effect of poor adjustment on…

  2. The Impact of Financial Sophistication on Adjustable Rate Mortgage Ownership

    ERIC Educational Resources Information Center

    Smith, Hyrum; Finke, Michael S.; Huston, Sandra J.

    2011-01-01

    The influence of a financial sophistication scale on adjustable-rate mortgage (ARM) borrowing is explored. Descriptive statistics and regression analysis using recent data from the Survey of Consumer Finances reveal that ARM borrowing is driven by both the least and most financially sophisticated households but for different reasons. Less…

  3. Relationships between Facial Discrimination and Social Adjustment in Mental Retardation

    ERIC Educational Resources Information Center

    Rojahn, Johannes; Esbensen, Anna J.; Hoch, Theodore A.

    2006-01-01

    Sixty-two adults with mental retardation of heterogeneous etiology performed four facial emotion discrimination tasks and two facial nonemotion tasks. Staff members familiar with the participants completed measures of social adjustment (the Socialization and Communication domains of the Vineland Adaptive Behavior Scales and the Social Performance…

  4. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...

  5. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...

  6. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...

  7. Cultural Adjustment and the Puerto Rican.

    ERIC Educational Resources Information Center

    Prewitt-Diaz, Joseph O.

    This review of the literature on cultural adjustment is divided into four sections: the nature of cultural adjustment; acculturation as a model of cultural adjustment; psychological responses to acculturation; and a model of cultural adjustment developed by the author as a result of his immigration from Puerto Rico to the United States mainland.…

  8. Adjusting to University: The Hong Kong Experience

    ERIC Educational Resources Information Center

    Yau, Hon Keung; Sun, Hongyi; Cheng, Alison Lai Fong

    2012-01-01

    Students' adjustment to the university environment is an important factor in predicting university outcomes and is crucial to their future achievements. University support to students' transition to university life can be divided into three dimensions: academic adjustment, social adjustment and psychological adjustment. However, these…

  9. Mining machine with adjustable jib

    SciTech Connect

    Hart, D.

    1987-05-26

    A mining machine is described having a pair of crawler tracks, a means for individually driving each of the crawler tracks, a frame mounted on the crawler tracks, an elongated jib carrying a sprocket at each end, an endless cutting chain supported on the sprockets, cutters and loading flights mounted on the endless cutting chain, and means on the frame supporting the elongated jib. The means support the elongated jib consisting of a bridge on the frame, at least one scissors linkage pivotally mounted on the bridge, and arm having a first end attached to the scissors linkage, a front plate mounted on the second end of the arm and means adjustably mounting the elongated jib on the front plate. The means adjustably mount the elongated jib on the front plate including a first means for rotating the elongated jib between a vertical position and a horizontal position.

  10. Coverage-adjusted entropy estimation.

    PubMed

    Vu, Vincent Q; Yu, Bin; Kass, Robert E

    2007-09-20

    Data on 'neural coding' have frequently been analyzed using information-theoretic measures. These formulations involve the fundamental and generally difficult statistical problem of estimating entropy. We review briefly several methods that have been advanced to estimate entropy and highlight a method, the coverage-adjusted entropy estimator (CAE), due to Chao and Shen that appeared recently in the environmental statistics literature. This method begins with the elementary Horvitz-Thompson estimator, developed for sampling from a finite population, and adjusts for the potential new species that have not yet been observed in the sample-these become the new patterns or 'words' in a spike train that have not yet been observed. The adjustment is due to I. J. Good, and is called the Good-Turing coverage estimate. We provide a new empirical regularization derivation of the coverage-adjusted probability estimator, which shrinks the maximum likelihood estimate. We prove that the CAE is consistent and first-order optimal, with rate O(P)(1/log n), in the class of distributions with finite entropy variance and that, within the class of distributions with finite qth moment of the log-likelihood, the Good-Turing coverage estimate and the total probability of unobserved words converge at rate O(P)(1/(log n)(q)). We then provide a simulation study of the estimator with standard distributions and examples from neuronal data, where observations are dependent. The results show that, with a minor modification, the CAE performs much better than the MLE and is better than the best upper bound estimator, due to Paninski, when the number of possible words m is unknown or infinite. PMID:17567838

  11. [Suicide risk and suicide attempt in North Pas de Calais Region. Lessons from the survey Mental Health in General Population].

    PubMed

    Danel, T; Vilain, J; Roelandt, J L; Salleron, J; Vaiva, G; Amariei, A; Amarie, A; Plancke, L; Plance, L; Duhamel, A

    2010-01-01

    The Santé Mentale en Population Générale Survey (Mental Health in General Population Survey (MHGP)) is a multicentre international research and action project initiated by the World Health Organisation Collaboration Centre for research and training in mental health. Its aims are to assess the prevalence of the major mental health disorders in the general adult population and from this to record perceptions associated with "mental illness", "madness" and "depression" together with different means of assistance and specialist or lay care. In this work we present the analysis of data on risks of suicide and past history of suicide attempts in the Nord pas de Calais region. We present the qualitative features of these phenomena and correlations with socio-economic, cultural and psychopathological factors, which are discussed in terms of both protective and vulnerability factors. Risk of suicide is present in 15% of the Nord pas de Calais population and is divided into 10.44% slight risk, 2.37% moderate risk and 2.2% high risk. A comparison with data from the MHGP survey in other regions reveals the high risk of suicide in the NPDC region. A risk of suicide is present is 13% of the population in other SMPG survey regions, broken down into 9.1% low risk, 2.1% medium risk and 1.7% high risk. Compared to the 2.2% high risk figure for NPDC, the population in this category is 21% larger. In terms of risk and protective factors, a bivariate analysis of socio-economic and cultural factors confirms the classical risk factors of sex, marital, occupational and educational status and income. The odds-ratio for these socio-economic and cultural factors can be calculated from logistic regression and the protective factors ranked in decreasing order from religion (Muslim versus other religions), martial status (marked versus separated), age (over 58 years old), occupational status (working or retired versus unemployed), income (more than 1300 euros versus less than 840 euros), sex

  12. Hardware and software facilities for the J-PAS and J-PLUS surveys archiving, processing and data publication

    NASA Astrophysics Data System (ADS)

    Cristóbal-Hornillos, D.; Varela, J.; Ederoclite, A.; Vázquez Ramió, H.; López-Sainz, A.; Hernández-Fuertes, J.; Civera, T.; Muniesa, D.; Moles, M.; Cenarro, A. J.; Marín-Franch, A.; Yanes-Díaz, A.

    2015-05-01

    The Observatorio Astrofísico de Javalambre consists of two main telescopes: JST/T250, a 2.5 m telescope with a FoV of 3 deg, and JAST/T80, a 83 cm with a 2 deg FoV. JST/T250 will be devoted to complete the Javalambre-PAU Astronomical Survey (J-PAS). It is a photometric survey with a system of 54 narrow-band plus 3 broad-band filters covering an area of 8500°^2. The JAST/T80 will perform the J-PLUS survey, covering the same area in a system of 12 filters. This contribution presents the software and hardware architecture designed to store and process the data. The processing pipeline runs daily and it is devoted to correct instrumental signature on the science images, to perform astrometric and photometric calibration, and the computation of individual image catalogs. In a second stage, the pipeline performs the combination of the tile mosaics and the computation of final catalogs. The catalogs are ingested in as Scientific database to be provided to the community. The processing software is connected with a management database to store persistent information about the pipeline operations done on each frame. The processing pipeline is executed in a computing cluster under a batch queuing system. Regarding the storage system, it will combine disk and tape technologies. The disk storage system will have capacity to store the data that is accessed by the pipeline. The tape library will store and archive the raw data and earlier data releases with lower access frequency.

  13. Genetic Evidence for Function of the bHLH-PAS Protein Gce/Met As a Juvenile Hormone Receptor.

    PubMed

    Jindra, Marek; Uhlirova, Mirka; Charles, Jean-Philippe; Smykal, Vlastimil; Hill, Ronald J

    2015-07-01

    Juvenile hormones (JHs) play a major role in controlling development and reproduction in insects and other arthropods. Synthetic JH-mimicking compounds such as methoprene are employed as potent insecticides against significant agricultural, household and disease vector pests. However, a receptor mediating effects of JH and its insecticidal mimics has long been the subject of controversy. The bHLH-PAS protein Methoprene-tolerant (Met), along with its Drosophila melanogaster paralog germ cell-expressed (Gce), has emerged as a prime JH receptor candidate, but critical evidence that this protein must bind JH to fulfill its role in normal insect development has been missing. Here, we show that Gce binds a native D. melanogaster JH, its precursor methyl farnesoate, and some synthetic JH mimics. Conditional on this ligand binding, Gce mediates JH-dependent gene expression and the hormone's vital role during development of the fly. Any one of three different single amino acid mutations in the ligand-binding pocket that prevent binding of JH to the protein block these functions. Only transgenic Gce capable of binding JH can restore sensitivity to JH mimics in D. melanogaster Met-null mutants and rescue viability in flies lacking both Gce and Met that would otherwise die at pupation. Similarly, the absence of Gce and Met can be compensated by expression of wild-type but not mutated transgenic D. melanogaster Met protein. This genetic evidence definitively establishes Gce/Met in a JH receptor role, thus resolving a long-standing question in arthropod biology. PMID:26161662

  14. Peripheral Insertion of a Central Venous Access Device Under Fluoroscopic Guidance Using a Peripherally Accessed System (PAS) Port in the Forearm

    SciTech Connect

    Hata, Yasuhiro; Morita, Sojiro; Morita, Yoshitaka; Awatani, Toshihide; Takasaki, Motohiro; Horimi, Tadashi; Ozawa, Zen

    1998-05-15

    Purpose: We describe the technique, efficacy, and complications of fluoroscopy-guided implantation of a central venous access device using a peripherally accessed system (PAS) port via the forearm. Methods: Beginning in July 1994, 105 central venous access devices were implanted in 104 patients for the long-term infusion of antibiotics or antineoplasmic agents, blood products, or parenteral nutrition. The devices was inserted under fluoroscopic guidance with real-time venography from a peripheral route. Results: All ports were successfully implanted. There were no procedure-related complications. No thrombosis or local infection was observed; however, in six patients catheter-related phlebitis occurred. Conclusion: Fluoroscopy-guided implantation of a central venous access device using a PAS port via the forearm is safe and efficacious, and injection of contrast medium through a peripheral IV catheter before introduction of the catheter helps to avoid catheter-related phlebitis.

  15. Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded.

    PubMed

    Coumailleau, P; Penrad-Mobayed, M; Lecomte, C; Bollérot, K; Simon, F; Poellinger, L; Angelier, N

    2000-12-01

    We have isolated a novel gene from Xenopus, denominated xSim, which encodes a protein of 760 amino acids containing a basic helix-loop-helix (bHLH) motif contiguous to a PAS domain characteristic of an emerging family of transcriptional regulators so called bHLH/PAS. xSim shares a strong amino acid sequence identity with the Drosophila Single-minded (dSim) and with the murine Sim1 and Sim2 proteins. Phylogenetic analysis reveals that xSim gene is an ortholog gene of the mSim2 gene. Spatio-temporal analysis shows a maternal and a zygotic expression of xSim throughout early Xenopus development. In situ hybridization assays reveal that the transcripts are enriched in the animal hemisphere until blastula stage and extend to the marginal zone at early gastrula stage. As development proceeds, xSim is mainly restricted to the central nervous system. PMID:11091086

  16. Adjustable link for kinematic mounting systems

    DOEpatents

    Hale, L.C.

    1997-07-01

    An adjustable link for kinematic mounting systems is disclosed. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two. 3 figs.

  17. Adjustable link for kinematic mounting systems

    DOEpatents

    Hale, Layton C.

    1997-01-01

    An adjustable link for kinematic mounting systems. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two.

  18. A concurrent comparison of isoniazid plus PAS with three regimens of isoniazid alone in the domiciliary treatment of pulmonary tuberculosis in South India

    PubMed Central

    1960-01-01

    Recent studies have shown that treatment of pulmonary tuberculosis with isoniazid plus p-aminosalicylic acid (PAS) at home is, in the majority of cases, as satisfactory as treatment with the same combination of drugs in sanatorium and does not appear to expose the patient's contacts to any special risk. Before mass domiciliary chemotherapy can be introduced, however, a question that has to be decided is what drug or drugs and what dosage and rhythm of administration will be most effective. This paper presents the results of a controlled comparison of four chemotherapeutic regimens: (a) 3.9-5.5 mg/kg body-weight of isoniazid plus 0.2-0.3 g/kg body-weight of PAS (sodium salt) daily in two doses (the standard combined chemotherapy); (b) 7.8-9.6 mg/kg body-weight of isoniazid alone daily in one dose; (c) 7.8-9.6 mg/kg body-weight of isoniazid alone daily in two doses; (d) 3.9-5.5 mg/kg body-weight of isoniazid alone daily in two doses. Isoniazid plus PAS proved to be the most satisfactory regimen; it was clinically effective and there were very few toxic manifestations. PMID:14447270

  19. PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1

    PubMed Central

    DeMille, Desiree; Badal, Bryan D.; Evans, J. Brady; Mathis, Andrew D.; Anderson, Joseph F.; Grose, Julianne H.

    2015-01-01

    We describe the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (AMPK, or SNF1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1). This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which phosphorylates and activates poly(A)- binding protein binding protein 1 (Pbp1), which then inhibits TORC1 through sequestration at stress granules. The SNF1-dependent phosphorylation of Psk1 appears to be direct, in that Snf1 is necessary and sufficient for Psk1 activation by alternate carbon sources, is required for altered Psk1 protein mobility, is able to phosphorylate Psk1 in vitro, and binds Psk1 via its substrate-targeting subunit Gal83. Evidence for the direct phosphorylation and activation of Pbp1 by Psk1 is also provided by in vitro and in vivo kinase assays, including the reduction of Pbp1 localization at distinct cytoplasmic foci and subsequent rescue of TORC1 inhibition in PAS kinase–deficient yeast. In support of this signaling cascade, Snf1-deficient cells display increased TORC1 activity, whereas cells containing hyperactive Snf1 display a PAS kinase–dependent decrease in TORC1 activity. This interplay between yeast SNF1, Psk1, and TORC1 allows for proper glucose allocation during nutrient depletion, reducing cell growth and proliferation when energy is low. PMID:25428989

  20. Correlates of household seismic hazard adjustment adoption.

    PubMed

    Lindell, M K; Whitney, D J

    2000-02-01

    This study examined the relationships of self-reported adoption of 12 seismic hazard adjustments (pre-impact actions to reduce danger to persons and property) with respondents' demographic characteristics, perceived risk, perceived hazard knowledge, perceived protection responsibility, and perceived attributes of the hazard adjustments. Consistent with theoretical predictions, perceived attributes of the hazard adjustments differentiated among the adjustments and had stronger correlations with adoption than any of the other predictors. These results identify the adjustments and attributes that emergency managers should address to have the greatest impact on improving household adjustment to earthquake hazard. PMID:10795335

  1. Adjustable extender for instrument module

    DOEpatents

    Sevec, J.B.; Stein, A.D.

    1975-11-01

    A blank extender module used to mount an instrument module in front of its console for repair or test purposes has been equipped with a rotatable mount and means for locking the mount at various angles of rotation for easy accessibility. The rotatable mount includes a horizontal conduit supported by bearings within the blank module. The conduit is spring-biased in a retracted position within the blank module and in this position a small gear mounted on the conduit periphery is locked by a fixed pawl. The conduit and instrument mount can be pulled into an extended position with the gear clearing the pawl to permit rotation and adjustment of the instrument.

  2. Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction

    SciTech Connect

    Cardoso, Rosa; Love, Robert; Nilsson, Carol L; Bergqvist, Simon; Nowlin, Dawn; Yan, Jiangli; Liu, Kevin K.-C.; Zhu, Jing; Chen, Ping; Deng, Ya-Li; Dyson, H Jane; Greig, Michael J; Brooun, Alexei

    2012-11-09

    The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking advantage of the presence of several cysteine residues located in the allosteric cavity of HIF-1α PasB domain, we applied a cysteine-based reactomics “hotspot identification” strategy to locate regions of HIF-1α PasB domain critical for its interaction with ARNT. COMPOUND 5 was identified using a mass spectrometry-based primary screening strategy and was shown to react specifically with Cys255 of the HIF-1α PasB domain. Biophysical characterization of the interaction between PasB domains of HIF-1α and ARNT revealed that covalent binding of COMPOUND 5 to Cys255 reduced binding affinity between HIF-1α and ARNT PasB domains approximately 10-fold. Detailed NMR structural analysis of HIF-1α-PasB-COMPOUND 5 conjugate showed significant local conformation changes in the HIF-1α associated with key residues involved in the HIF-1α/ARNT PasB domain interaction as revealed by the crystal structure of the HIF-1α/ARNT PasB heterodimer. Our screening strategy could be applied to other targets to identify pockets surrounding reactive cysteines suitable for development of small molecule modulators of protein function.

  3. Rural Elderly: Impact of Social, Psychological Health and Demographic Experiences on Adjustment in Women and Men.

    ERIC Educational Resources Information Center

    Maiden, R.; And Others

    An amended form of the Older American's Status and Needs Assessment Questionnaire assessed the prevalence of adjustment, as measured by the Bradburn Affect Scale, in a random stratified sample of 301 female and 140 male elderly rural residents in Allegany County, New York. The relationship between adjustment and biosocial, demographic, social, and…

  4. Marital Adjustment Over the Family Life Cycle: The Issue of Curvilinearity.

    ERIC Educational Resources Information Center

    Spanier, Graham B.; And Others

    Marital adjustment over the family life cycle is reexamined using data from probability samples of married couples studied in coordinated research projects in three different states--Iowa, Ohio, and Georgia. A total of 1,584 respondents completed the Locke-Wallace Marital Adjustment Scale and responded to questions about stage of the family life…

  5. The Impact of TV Viewing Motivations on Psychological and Sociocultural Adjustment.

    ERIC Educational Resources Information Center

    Chen, Guo-Ming

    A study examined the impact of TV viewing motivations on 126 Asian students' psychological and sociocultural adjustment. Subjects were enrolled in a midsize university in the New England area. TV viewing motivation was measured by A. M. Rubin's TV Viewing Motivations Scale. Psychological adjustment was measured by W. Zung's Self Rating Depression…

  6. The Effects of Coping Humour and Gender on College Adjustment in Turkish Freshmen

    ERIC Educational Resources Information Center

    Oguz-Duran, Nagihan; Yuksel, Asuman

    2010-01-01

    The purpose of this study was to investigate the roles of coping humour and gender in the college adjustment of Turkish freshmen. Considering greater happiness and academic achievement as predictors of initial college adjustment, data were gathered from a sample of 574 students using the Subjective Well-Being Scale (SWS) and the Coping Humour…

  7. The dyadic adjustment of female-to-male transsexuals.

    PubMed

    Fleming, M; MacGowan, B; Costos, D

    1985-02-01

    Dyadic adjustment, sexual activities, and marital stability in the relationships of female-to-male transsexuals and their spouses were examined. Participants were 22 female-to-male transsexuals who had undergone some form of surgery to alter their anatomical sex, their spouses, and a control group of married or cohabitating nontranssexual men and women. Participants were administered the Dyadic Adjustment Scale and additional items to assess quantitatively their marital relationships. The transsexuals and their spouses were also asked open-ended interview questions concerning marital and life adjustments. Generally, the transsexuals and their spouses reported good and mutually satisfying interpersonal relationships that are in many ways comparable to those of the matched control group. These findings lend support to the previous clinical interview studies that have reported that female-to-male transsexuals form stable and enduring intimate relationships. PMID:3977583

  8. Adjusting the Contour of Reflector Panels

    NASA Technical Reports Server (NTRS)

    Palmer, W. B.; Giebler, M. M.

    1984-01-01

    Postfabrication adjustment of contour of panels for reflector, such as parabolic reflector for radio antennas, possible with simple mechanism consisting of threaded stud, two nuts, and flexure. Contours adjusted manually.

  9. 48 CFR 1450.103 - Contract adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract adjustments. 1450.103 Section 1450.103 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT... Contract adjustments....

  10. Estimation of Data Uncertainty Adjustment Parameters for Multivariate Earth Rotation Series

    NASA Technical Reports Server (NTRS)

    Sung, Li-yu; Steppe, J. Alan

    1994-01-01

    We have developed a maximum likelihood method to estimate a set of data uncertainty adjustment parameters, iccluding scaling factors and additive variances and covariances, for multivariate Earth rotation series.

  11. 76 FR 4395 - Postal Service Price Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Postal Service Price Adjustment AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recently-filed Postal Service request to establish price adjustments for all market... with the Commission announcing price adjustments, effective April 17, 2011, affecting all...

  12. 12 CFR 1780.80 - Inflation adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Inflation adjustments. 1780.80 Section 1780.80... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Civil Money Penalty Inflation Adjustments § 1780.80 Inflation adjustments. The maximum amount of each civil money penalty within...

  13. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum,...

  14. 19 CFR 201.205 - Salary adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Salary adjustments. 201.205 Section 201.205 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt Collection § 201.205 Salary adjustments. Any negative adjustment to pay arising out of an employee's...

  15. 19 CFR 201.205 - Salary adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Salary adjustments. 201.205 Section 201.205 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt Collection § 201.205 Salary adjustments. Any negative adjustment to pay arising out of an employee's...

  16. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum,...

  17. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum,...

  18. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum,...

  19. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum,...

  20. 12 CFR 1780.80 - Inflation adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Inflation adjustments. 1780.80 Section 1780.80... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Civil Money Penalty Inflation Adjustments § 1780.80 Inflation adjustments. The maximum amount of each civil money penalty within...

  1. Adjustment to College in Students with ADHD

    ERIC Educational Resources Information Center

    Rabiner, David L.; Anastopoulos, Arthur D.; Costello, Jane; Hoyle, Rick H.; Swartzwelder, H. Scott

    2008-01-01

    Objective: To examine college adjustment in students reporting an ADHD diagnosis and the effect of medication treatment on students' adjustment. Method: 1,648 first-semester freshmen attending a public and a private university completed a Web-based survey to examine their adjustment to college. Results: Compared with 200 randomly selected control…

  2. Dimensions of Adjustment among College Women.

    ERIC Educational Resources Information Center

    Tomlinson-Clarke, Saundra

    1998-01-01

    Examines academic, social, and personal-emotional adjustment, as well as institutional attachment for women (N=198) attending a predominantly white coeducational research university. Significant main effects were found on academic achievement for year in college. Students differed on personal-emotional adjustment by race. Academic adjustment and…

  3. COOPERATION MAINTAINED BY FITNESS ADJUSTMENT

    PubMed Central

    TAYLOR, CHRISTINE; CHEN, JANET; IWASA, YOH

    2008-01-01

    Questions Whether or not cooperation can be enhanced if players with a performance higher than the mean are forced to pay an additional cost in each generation? Mathematical Methods Analysis of replicator dynamics with mutation. The ESS distribution of cooperation level is obtained. Key Assumptions Players engage in cooperative dilemma game, and at the end of each generation, those with higher performance than the mean are forced to pay additional cost. Conclusions Without mutation, the entire population eventually conforms to a single cooperation level determined by the initial composition of the population. With mutation, there is an equilibrium distribution of cooperation level, which has a peak at an intermediate level of cooperation. Whether it is institutionalized such as tax or just a social custom, fitness adjustment based ultimately on people’s emtion of “envy” is able to maintain cooperation. PMID:19079742

  4. Exploring Scaling: From Concept to Applications

    ERIC Educational Resources Information Center

    Milner-Bolotin, Marina

    2009-01-01

    This paper discusses the concept of scaling and its biological and engineering applications. Scaling, in a scientific context, means proportional adjustment of the dimensions of an object so that the adjusted and original objects have similar shapes yet different dimensions. The paper provides an example of a hands-on, minds-on activity on scaling…

  5. Genome-wide survey and expression analysis of the bHLH-PAS genes in the amphioxus Branchiostoma floridae reveal both conserved and diverged expression patterns between cephalochordates and vertebrates

    PubMed Central

    2014-01-01

    Background The bHLH-PAS transcription factors are found in both protostomes and deuterostomes. They are involved in many developmental and physiological processes, including regional differentiation of the central nervous system, tube-formation, hypoxia signaling, aromatic hydrocarbon sensing, and circadian rhythm regulation. To understand the evolution of these genes in chordates, we analyzed the bHLH-PAS genes of the basal chordate amphioxus (Branchiostoma floridae). Results From the amphioxus draft genome database, we identified ten bHLH-PAS genes, nine of which could be assigned to known orthologous families. The tenth bHLH-PAS gene could not be assigned confidently to any known bHLH family; however, phylogenetic analysis clustered this gene with arthropod Met family genes and two spiralian bHLH-PAS-containing sequences, suggesting that they may share the same ancestry. We examined temporal and spatial expression patterns of these bHLH-PAS genes in developing amphioxus embryos. We found that BfArnt, BfNcoa, BfSim, and BfHifα were expressed in the central nervous system in patterns similar to those of their vertebrate homologs, suggesting that their functions may be conserved. By contrast, the amphioxus BfAhr and BfNpas4 had expression patterns distinct from those in vertebrates. These results imply that there were changes in gene regulation after the divergence of cephalochordates and vertebrates. Conclusions We have identified ten bHLH-PAS genes from the amphioxus genome and determined the embryonic expression profiles for these genes. In addition to the nine currently recognized bHLH-PAS families, our survey suggests that the BfbHLHPAS-orphan gene along with arthropod Met genes and the newly identified spiralian bHLH-PAS-containing sequences represent an ancient group of genes that were lost in the vertebrate lineage. In a comparison with the expression patterns of the vertebrate bHLH-PAS paralogs, which are the result of whole-genome duplication, we found

  6. Regulation of Coronafacoyl Phytotoxin Production by the PAS-LuxR Family Regulator CfaR in the Common Scab Pathogen Streptomyces scabies

    PubMed Central

    Cheng, Zhenlong; Bown, Luke; Tahlan, Kapil; Bignell, Dawn R. D.

    2015-01-01

    Potato common scab is an economically important crop disease that is characterized by the formation of superficial, raised or pitted lesions on the potato tuber surface. The most widely distributed causative agent of the disease is Streptomyces scabies, which produces the phytotoxic secondary metabolite thaxtomin A that serves as a key virulence factor for the organism. Recently, it was demonstrated that S. scabies can also produce the phytotoxic secondary metabolite coronafacoyl-L-isoleucine (CFA-L-Ile) as well as other related metabolites in minor amounts. The expression of the biosynthetic genes for CFA-L-Ile production is dependent on a PAS-LuxR family transcriptional regulator, CfaR, which is encoded within the phytotoxin biosynthetic gene cluster in S. scabies. In this study, we show that CfaR activates coronafacoyl phytotoxin production by binding to a single site located immediately upstream of the putative -35 hexanucleotide box within the promoter region for the biosynthetic genes. The binding activity of CfaR was shown to require both the LuxR and PAS domains, the latter of which is involved in protein homodimer formation. We also show that CFA-L-Ile production is greatly enhanced in S. scabies by overexpression of both cfaR and a downstream co-transcribed gene, orf1. Our results provide important insight into the regulation of coronafacoyl phytotoxin production, which is thought to contribute to the virulence phenotype of S. scabies. Furthermore, we provide evidence that CfaR is a novel member of the PAS-LuxR family of regulators, members of which are widely distributed among actinomycete bacteria. PMID:25826255

  7. Regulation of coronafacoyl phytotoxin production by the PAS-LuxR family regulator CfaR in the common scab pathogen Streptomyces scabies.

    PubMed

    Cheng, Zhenlong; Bown, Luke; Tahlan, Kapil; Bignell, Dawn R D

    2015-01-01

    Potato common scab is an economically important crop disease that is characterized by the formation of superficial, raised or pitted lesions on the potato tuber surface. The most widely distributed causative agent of the disease is Streptomyces scabies, which produces the phytotoxic secondary metabolite thaxtomin A that serves as a key virulence factor for the organism. Recently, it was demonstrated that S. scabies can also produce the phytotoxic secondary metabolite coronafacoyl-L-isoleucine (CFA-L-Ile) as well as other related metabolites in minor amounts. The expression of the biosynthetic genes for CFA-L-Ile production is dependent on a PAS-LuxR family transcriptional regulator, CfaR, which is encoded within the phytotoxin biosynthetic gene cluster in S. scabies. In this study, we show that CfaR activates coronafacoyl phytotoxin production by binding to a single site located immediately upstream of the putative -35 hexanucleotide box within the promoter region for the biosynthetic genes. The binding activity of CfaR was shown to require both the LuxR and PAS domains, the latter of which is involved in protein homodimer formation. We also show that CFA-L-Ile production is greatly enhanced in S. scabies by overexpression of both cfaR and a downstream co-transcribed gene, orf1. Our results provide important insight into the regulation of coronafacoyl phytotoxin production, which is thought to contribute to the virulence phenotype of S. scabies. Furthermore, we provide evidence that CfaR is a novel member of the PAS-LuxR family of regulators, members of which are widely distributed among actinomycete bacteria. PMID:25826255

  8. Local Scale Comparisons of Biodiversity as a Test for Global Protected Area Ecological Performance: A Meta-Analysis

    PubMed Central

    Coetzee, Bernard W. T.; Gaston, Kevin J.; Chown, Steven L.

    2014-01-01

    Terrestrial protected areas (PAs) are cornerstones of global biodiversity conservation. Their efficacy in terms of maintaining biodiversity is, however, much debated. Studies to date have been unable to provide a general answer as to PA conservation efficacy because of their typically restricted geographic and/or taxonomic focus, or qualitative approaches focusing on proxies for biodiversity, such as deforestation. Given the rarity of historical data to enable comparisons of biodiversity before/after PA establishment, many smaller scale studies over the past 30 years have directly compared biodiversity inside PAs to that of surrounding areas, which provides one measure of PA ecological performance. Here we use a meta-analysis of such studies (N = 86) to test if PAs contain higher biodiversity values than surrounding areas, and so assess their contribution to determining PA efficacy. We find that PAs generally have higher abundances of individual species, higher assemblage abundances, and higher species richness values compared with alternative land uses. Local scale studies in combination thus show that PAs retain more biodiversity than alternative land use areas. Nonetheless, much variation is present in the effect sizes, which underscores the context-specificity of PA efficacy. PMID:25162620

  9. Exploration adjustment by ant colonies

    PubMed Central

    2016-01-01

    How do animals in groups organize their work? Division of labour, i.e. the process by which individuals within a group choose which tasks to perform, has been extensively studied in social insects. Variability among individuals within a colony seems to underpin both the decision over which tasks to perform and the amount of effort to invest in a task. Studies have focused mainly on discrete tasks, i.e. tasks with a recognizable end. Here, we study the distribution of effort in nest seeking, in the absence of new nest sites. Hence, this task is open-ended and individuals have to decide when to stop searching, even though the task has not been completed. We show that collective search effort declines when colonies inhabit better homes, as a consequence of a reduction in the number of bouts (exploratory events). Furthermore, we show an increase in bout exploration time and a decrease in bout instantaneous speed for colonies inhabiting better homes. The effect of treatment on bout effort is very small; however, we suggest that the organization of work performed within nest searching is achieved both by a process of self-selection of the most hard-working ants and individual effort adjustment. PMID:26909180

  10. Exploration adjustment by ant colonies.

    PubMed

    Doran, Carolina; Stumpe, Martin C; Sendova-Franks, Ana; Franks, Nigel R

    2016-01-01

    How do animals in groups organize their work? Division of labour, i.e. the process by which individuals within a group choose which tasks to perform, has been extensively studied in social insects. Variability among individuals within a colony seems to underpin both the decision over which tasks to perform and the amount of effort to invest in a task. Studies have focused mainly on discrete tasks, i.e. tasks with a recognizable end. Here, we study the distribution of effort in nest seeking, in the absence of new nest sites. Hence, this task is open-ended and individuals have to decide when to stop searching, even though the task has not been completed. We show that collective search effort declines when colonies inhabit better homes, as a consequence of a reduction in the number of bouts (exploratory events). Furthermore, we show an increase in bout exploration time and a decrease in bout instantaneous speed for colonies inhabiting better homes. The effect of treatment on bout effort is very small; however, we suggest that the organization of work performed within nest searching is achieved both by a process of self-selection of the most hard-working ants and individual effort adjustment. PMID:26909180

  11. A comparative evaluation of methods of adjusting GPA for differences in grade assignment practices.

    PubMed

    Lei, Pui-Wa; Bassiri, Dina; Schulz, E Matthew

    2003-01-01

    Numerous methods have been proposed for constructing an adjusted grade point average (adjusted-GPA) that controls for differences in grading standards across college courses and departments. Compared to the raw GPA, adjusted-GPA measures are generally more predictable from preadmissions variables, such as standardized tests and high school achievement. Relative rankings of students on adjusted-GPA measures are also more consistent with their relative standings within courses. This study compared the performance of 4 polytomous IRT and 3 linear models for constructing adjusted-GPA measures. Unlike previous studies, the regression weights of predictor variables and the course parameter estimates used to compute adjusted-GPA were cross-validated. Adjusted-GPA retained noticeable advantages over raw GPA on cross-validation. The largest advantages were seen in the multiple correlation of adjusted-GPA with preadmission variables, when adjusted-GPA was constructed with the rating scale and partial credit IRT models. The cross-validity of adjusted-GPA was the weakest with the graded response model. PMID:12700432

  12. Resonance Parameter Adjustment Based on Integral Experiments

    DOE PAGESBeta

    Sobes, Vladimir; Leal, Luiz; Arbanas, Goran; Forget, Benoit

    2016-06-02

    Our project seeks to allow coupling of differential and integral data evaluation in a continuous-energy framework and to use the generalized linear least-squares (GLLS) methodology in the TSURFER module of the SCALE code package to update the parameters of a resolved resonance region evaluation. We recognize that the GLLS methodology in TSURFER is identical to the mathematical description of a Bayesian update in SAMMY, the SAMINT code was created to use the mathematical machinery of SAMMY to update resolved resonance parameters based on integral data. Traditionally, SAMMY used differential experimental data to adjust nuclear data parameters. Integral experimental data, suchmore » as in the International Criticality Safety Benchmark Experiments Project, remain a tool for validation of completed nuclear data evaluations. SAMINT extracts information from integral benchmarks to aid the nuclear data evaluation process. Later, integral data can be used to resolve any remaining ambiguity between differential data sets, highlight troublesome energy regions, determine key nuclear data parameters for integral benchmark calculations, and improve the nuclear data covariance matrix evaluation. Moreover, SAMINT is not intended to bias nuclear data toward specific integral experiments but should be used to supplement the evaluation of differential experimental data. Using GLLS ensures proper weight is given to the differential data.« less

  13. Automatic Focus Adjustment of a Microscope

    NASA Technical Reports Server (NTRS)

    Huntsberger, Terrance

    2005-01-01

    AUTOFOCUS is a computer program for use in a control system that automatically adjusts the position of an instrument arm that carries a microscope equipped with an electronic camera. In the original intended application of AUTOFOCUS, the imaging microscope would be carried by an exploratory robotic vehicle on a remote planet, but AUTOFOCUS could also be adapted to similar applications on Earth. Initially control software other than AUTOFOCUS brings the microscope to a position above a target to be imaged. Then the instrument arm is moved to lower the microscope toward the target: nominally, the target is approached from a starting distance of 3 cm in 10 steps of 3 mm each. After each step, the image in the camera is subjected to a wavelet transform, which is used to evaluate the texture in the image at multiple scales to determine whether and by how much the microscope is approaching focus. A focus measure is derived from the transform and used to guide the arm to bring the microscope to the focal height. When the analysis reveals that the microscope is in focus, image data are recorded and transmitted.

  14. Inverting Glacial Isostatic Adjustment with Paleo Sea Level Records using Bayesian Framework and Burgers Rheology

    NASA Astrophysics Data System (ADS)

    Caron, L.; Metivier, L.; Greff-Lefftz, M.; Fleitout, L.; Rouby, H.

    2015-12-01

    Glacial Isostatic Adjustment models most often assume a mantle with a viscoelastic Maxwell rheology and a given ice history model. Here we use a Bayesian Monte Carlo with Markov Chains formalism to invert the global GIA signal simultaneously for the mechanical properties of the mantle and for the volume of the various ice-sheets using as starting ice models two distinct previously published ice histories. Burgers as well as Maxwell rheologies are considered.The fitted data consist of 5720 paleo sea level records from the last 35kyrs, with a world-wide distribution. Our ambition is to present not only the best fitting model, but also the range of possible solutions (within the explored space of parameters) with their respective probability of explaining the data, and thus reveal the trade-off effects and range of uncertainty affecting the parameters. Our a posteriori probality maps exhibit in all cases two distinct peaks: both are characterized by an upper mantle viscosity around 5.1020Pa.s but one of the peaks features a lower mantle viscosity around 3.1021Pa.s while the other indicates lower mantle viscosity of more than 1.1022Pa.s. The global maximum depends upon the starting ice history and the chosen rheology: the first peak (P1) has the highest probability only in the case with a Maxwell rheology and ice history based on ICE-5G, while the second peak (P2) is favored when using ANU-based ice history or Burgers rheology, and is our preferred solution as it is also consistent with long-term geodynamics and gravity gradients anomalies over Laurentide. P2 is associated with larger volumes for the Laurentian and Fennoscandian ice-sheets and as a consequence of total ice volume balance, smaller volumes for the Antactic ice-sheet. This last point interfers with the estimate of present-day ice-melting in Antarctica from GRACE data. Finally, we find that P2 with Burgers rheology favors the existence of a tectosphere, i.e. a viscous sublithospheric layer.

  15. Ergonomic evaluation of the Apple Adjustable Keyboard

    SciTech Connect

    Tittiranonda, P.; Burastero, S.; Shih, M.; Rempel, D.

    1994-05-01

    This study presents an evaluation of the Apple Adjustable Keyboard based on subjective preference and observed joint angles during typing. Thirty five keyboard users were asked to use the Apple adjustable keyboard for 7--14 days and rate the various characteristics of the keyboard. Our findings suggest that the most preferred opening angles range from 11--20{degree}. The mean ulnar deviation on the Apple Adjustable keyboard is 11{degree}, compared to 16{degree} on the standard keyboard. The mean extension was decreased from 24{degree} to 16{degree} when using the adjustable keyboard. When asked to subjectively rate the adjustable keyboard in comparison to the standard, the average subject felt that the Apple Adjustable Keyboard was more comfortable and easier to use than the standard flat keyboard.

  16. Efficient Adjustable Reflectivity Smart Window

    SciTech Connect

    D. Morgan Tench

    2005-12-01

    This project addressed the key technical issues for development of an efficient smart window based on reversible electrochemical transfer of silver between a mirror electrode and a localized counter electrode. Effort to provide uniform switching over large areas focused on use of a resistive transparent electrode innerlayer to increase the interelectrode resistance. An effective edge seal was developed in collaboration with adhesive suppliers and an electrochromic device manufacturer. Work to provide a manufacturable counter electrode focused on fabricating a dot matrix electrode without photolithography by electrodeposition of Pt nuclei on inherent active sites on a transparent oxide conductor. An alternative counter electrode based on a conducting polymer and an ionic liquid electrolyte was also investigated. Work in all of these areas was successful. Sputtered large-bandgap oxide innerlayers sandwiched between conductive indium tin oxide (ITO) layers were shown to provide sufficient cross-layer resistance (>300 ohm/cm{sup 2}) without significantly affecting the electrochemical properties of the ITO overlayer. Two edge seal epoxies, one procured from an epoxy manufacturer and one provided by an electrochromic device manufacturer in finished seals, were shown to be effective barriers against oxygen intrusion up to 80 C. The optimum density of nuclei for the dot matrix counter electrode was attained without use of photolithography by electrodeposition from a commercial alkaline platinum plating bath. Silver loss issues for cells with dot matrix electrodes were successfully addressed by purifying the electrolyte and adjusting the cell cycling parameters. More than 30K cycles were demonstrated for a REM cell (30-cm square) with a dot matrix counter electrode. Larger cells (30-cm square) were successfully fabricated but could not be cycled since the nucleation layers (provided by an outside supplier) were defective so that mirror deposits could not be produced.

  17. Three-dimensional adjustment of trilateration data

    NASA Technical Reports Server (NTRS)

    Sung, L.-Y.; Jackson, D. D.

    1985-01-01

    The three-dimensional locations of the monuments in the USGS Hollister trilateration network were adjusted to fit line length observations observed in 1977, using a Bayesian approach, and incorporating prior elevation estimates as data in the adjustment procedure. No significant discrepancies in the measured line lengths were found, but significant elevation adjustments (up to 1.85 m) were needed to fit the length data.

  18. Asian immigrant settlement and adjustment in Australia.

    PubMed

    Khoo, S; Kee, P; Dang, T; Shu, J

    1994-01-01

    "This article provides a broad assessment of the settlement and adjustment of people born in the many countries of Asia who are resident in Australia, based on recently available data from the 1991 Census of Population and Housing. It examines some indicators of economic adjustment such as performance in the labor market, and some indicators of social adjustment, such as acquisition of English language proficiency." PMID:12289777

  19. 27 CFR 19.276 - Package scales.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Package scales. 19.276... Package scales. Proprietors shall ensure the accuracy of scales used for weighing packages of spirits through tests conducted at intervals of not more than 6 months or whenever scales are adjusted or...

  20. Rate adjusters for Medicare under capitation

    PubMed Central

    Newhouse, Joseph P.

    1986-01-01

    This article addresses three issues related to capitation. First, the average adjusted per capita cost (AAPCC) fluctuates with the mix of risks in the fee-for-service system. More sensitive adjusters in the AAPCC are needed. Second, the AAPCC, as now estimated, exhibits large geographic variance; so-called shrinkage estimators may help. Third, the AAPCC requires new adjusters to yield more homogeneous risk classes. Otherwise, the portion of the Medicare population under capitation may experience access problems at alternative delivery systems: Until such adjusters are developed, it seems better to rely upon a blend of capitation and fee-for-service than the present AAPCC. PMID:10311926

  1. Techniques and applications of adjustable sutures.

    PubMed

    Fells, P

    1987-02-01

    The 'rediscovery' of adjustable sutures some 10 years ago has given the ophthalmic surgeon much more confidence in his ability to correct strabismus. Three methods of use are described: during surgery under general anaesthesia with adjustment during the operation using the 'springback' test to centralise the eye; during surgery under general anaesthesia and subsequent adjustment under local anaesthesia using the patient's subjective responses to obtain optimal positioning; and performance of the operation and adjustment under topical local anaesthesia in one procedure. Full details are given of each technique and the indications for their application to particular problems are discussed. PMID:3297111

  2. Fate of prions in soil: interactions of RecPrP with organic matter of soil aggregates as revealed by LTA-PAS.

    PubMed

    Pucci, Amaranta; D'Acqui, Luigi Paolo; Calamai, Luca

    2008-02-01

    The contribution of soil organic matter (OM) to the adsorption of a recombinant prion protein (RecPrP) was studied in microcosm systems (soil aggregates from two different soils) before and after OM removal by low temperature ashing (LTA). The LTA technique allows a controlled removal of OM layer by layer, like a peeling of an onion skin, with minimal disturbance of the mineral matrix. Soil aggregates were selected as a representative model of the "in situ" conditions. Adsorption from batch vs percolation experiments were compared, and the aggregates were characterized by photoacustic Fourier-transform IR spectroscopy (PAS-FTIR). High affinity (H-type) adsorption isotherms were found with complete removal of RecPrP from solution for protein/soil ratios up to 1:62.5. OM removal from aggregates decreased the adsorbed RecPrP in amounts corresponding to 330-1000 microg mg(-1) of soil organic carbon (OC) indicating that native OM has specific adsorption capacity comparable and/or superior to the mineral matrix. The coupled LTA-PAS-FTIR approach demonstrated that, albeit OM composition was homogeneous throughout the aggregates, its presence in the most external surfaces of the aggregates affects the diffusion dynamics of RecPrP within the aggregates during percolation. PMID:18323094

  3. The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition.

    PubMed

    Machuca, Mayra A; Liu, Yu C; Beckham, Simone A; Gunzburg, Menachem J; Roujeinikova, Anna

    2016-05-01

    Chemotaxis and motility play an important role in the colonisation of avian and human hosts by Campylobacter jejuni. Chemotactic recognition of extracellular signals is mediated by the periplasmic sensing domain of methyl-accepting chemotactic proteins (membrane-embedded receptors). In this work, we report a high-resolution structure of the periplasmic sensing domain of transducer-like protein 1 (Tlp1), an aspartate receptor of C. jejuni. Crystallographic analysis revealed that it contains two Per-Arnt-Sim (PAS) subdomains. An acetate and chloride ions (both from the crystallisation buffer) were observed bound to the membrane-proximal and membrane-distal PAS subdomains, respectively. Surprisingly, despite being crystallised in the presence of aspartate, the structure did not show any electron density corresponding to this amino acid. Furthermore, no binding between the sensing domain of Tlp1 and aspartate was detected by microcalorimetric experiments. These structural and biophysical data suggest that Tlp1 does not sense aspartate directly; instead, ligand recognition is likely to occur indirectly via an as yet unidentified periplasmic binding protein. PMID:26923153

  4. On the adjustment of inconsistent data using the Birge ratio

    NASA Astrophysics Data System (ADS)

    Bodnar, Olha; Elster, Clemens

    2014-10-01

    The Birge ratio is applied in metrology to enlarge quoted uncertainties when combining inconsistent measurement results on the same measurand. We discuss the statistical model underlying such a procedure and argue that the resulting uncertainty associated with the adjusted value is underrated. We provide a simple modification of this uncertainty on the basis of an objective Bayesian inference. While the proposed uncertainty approaches that obtained by the conventional procedure for a large number n of combined measurement results, differences are significant for small n. For example, for n = 4 we get an increase of 73% in the standard uncertainty associated with the adjusted value, and for n = 10 the increase is still 13%. We derive the posterior distribution for the adjusted value in closed form, including a 95% credible interval. In addition, we show that our results do not only hold when the distribution of the measurement results is assumed to be Gaussian, but for a whole family of (elliptically contoured) location-scale distributions. We illustrate the modified Birge method by its application to data from the 2002 adjustment of the Newtonian constant of gravitation.

  5. Distressing Sexual Problems and Dyadic Adjustment in Heterosexuals, Gay Men, and Lesbian Women.

    PubMed

    Peixoto, Maria Manuela; Nobre, Pedro

    2016-05-18

    Empirical studies have focused on dyadic adjustment and sexual satisfaction in men and women. Nevertheless, little is known regarding the role of dyadic adjustment in sexual problems among individuals in same-sex and mixed-sex dyads. The aim of the current study was to analyze the differences in dyadic adjustment between gay and heterosexual men, and lesbian and heterosexual women, with and without distressing sexual problems. One hundred and sixty men (80 gay and 80 heterosexual) and 184 women (92 lesbian and 92 heterosexual) completed an online survey. Participants responded to the Dyadic Adjustment Scale-Short Version and to questions about self-perceived sexual problems and associated levels of distress. A 2 (gender) × 2 (sexual orientation) × 2 (group with or without sexual problems) univariate analysis of covariance was performed. The findings suggested that individuals with distressing sexual problems, regardless of gender or sexual orientation, scored significantly lower on the Dyadic Adjustment Scale. Additionally, lesbian women, regardless of having or not having a distressing sexual problem, scored significantly higher on the Dyadic Adjustment Scale, compared to heterosexual women. No gender differences were found. Overall, our findings emphasize the negative association between dyadic adjustment and distressing sexual problems, regardless of gender and sexual orientation. PMID:26010170

  6. Ratios as a size adjustment in morphometrics.

    PubMed

    Albrecht, G H; Gelvin, B R; Hartman, S E

    1993-08-01

    Simple ratios in which a measurement variable is divided by a size variable are commonly used but known to be inadequate for eliminating size correlations from morphometric data. Deficiencies in the simple ratio can be alleviated by incorporating regression coefficients describing the bivariate relationship between the measurement and size variables. Recommendations have included: 1) subtracting the regression intercept to force the bivariate relationship through the origin (intercept-adjusted ratios); 2) exponentiating either the measurement or the size variable using an allometry coefficient to achieve linearity (allometrically adjusted ratios); or 3) both subtracting the intercept and exponentiating (fully adjusted ratios). These three strategies for deriving size-adjusted ratios imply different data models for describing the bivariate relationship between the measurement and size variables (i.e., the linear, simple allometric, and full allometric models, respectively). Algebraic rearrangement of the equation associated with each data model leads to a correctly formulated adjusted ratio whose expected value is constant (i.e., size correlation is eliminated). Alternatively, simple algebra can be used to derive an expected value function for assessing whether any proposed ratio formula is effective in eliminating size correlations. Some published ratio adjustments were incorrectly formulated as indicated by expected values that remain a function of size after ratio transformation. Regression coefficients incorporated into adjusted ratios must be estimated using least-squares regression of the measurement variable on the size variable. Use of parameters estimated by any other regression technique (e.g., major axis or reduced major axis) results in residual correlations between size and the adjusted measurement variable. Correctly formulated adjusted ratios, whose parameters are estimated by least-squares methods, do control for size correlations. The size-adjusted

  7. Stress and Coping as Predictors of Young Children's Development and Psychosocial Adjustment.

    ERIC Educational Resources Information Center

    Carson, David K.; Swanson, Dee M.

    A total of 38 children of 5-6 years in one of four early childhood or kindergarten programs participated in a study of the predictive relationship of stress and coping to development and psychosocial adjustment. Measures of independent variables included the Life Events Scale for Children, Family Invulnerability Test, Hassles Scale for Children,…

  8. Relation between Assertiveness, Academic Self-Efficacy, and Psychosocial Adjustment among International Graduate Students.

    ERIC Educational Resources Information Center

    Poyrazli, Senel; Arbona, Consuelo; Nora, Amaury; McPherson, Robert; Pisecco, Stewart

    2002-01-01

    Rathus Assertiveness Schedule, Academic Self-Efficacy Scale, The Inventory for Student Adjustment Strain, and UCLA Loneliness Scale were used to examine a total of 122 graduate international students. Findings indicate that English proficiency, assertiveness, and academic self-efficacy contributed uniquely to the variance in students' general…

  9. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 11, 2008, and before the effective date of any future inflation adjustment thereto made...

  10. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 7, 2012, and before the effective date of any future inflation adjustment thereto made...

  11. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 11, 2008, and before the effective date of any future inflation adjustment thereto made...

  12. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 11, 2008, and before the effective date of any future inflation adjustment thereto made...

  13. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 7, 2012, and before the effective date of any future inflation adjustment thereto made...

  14. 7 CFR 718.110 - Adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Adjustments. 718.110 Section 718.110 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE FARM... Determination of Acreage and Compliance § 718.110 Adjustments. (a) The farm operator or other...

  15. 7 CFR 718.110 - Adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Adjustments. 718.110 Section 718.110 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE FARM... Determination of Acreage and Compliance § 718.110 Adjustments. (a) The farm operator or other...

  16. 7 CFR 718.110 - Adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Adjustments. 718.110 Section 718.110 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE FARM... Determination of Acreage and Compliance § 718.110 Adjustments. (a) The farm operator or other...

  17. 45 CFR 84.44 - Academic adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Academic adjustments. 84.44 Section 84.44 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 84.44 Academic adjustments. (a)...

  18. 22 CFR 142.44 - Academic adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Academic adjustments. 142.44 Section 142.44 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 142.44 Academic adjustments. (a) Academic requirements. A...

  19. Marital Adjustment among Housestaff and New Attorneys.

    ERIC Educational Resources Information Center

    Spendlove, David C.; And Others

    1990-01-01

    This study, involving 116 housestaff physicians, 106 new attorneys, and the spouses of both groups, identified the factors that significantly affected their marital adjustments. No differences were found. The most important factor associated with adjustment was perceived level of emotional support from one's spouse. (Author/MLW)

  20. 15 CFR 6.6 - Subsequent adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Subsequent adjustments. 6.6 Section 6.6 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION... once every four years after October 23, 1996, make the inflation adjustment, described in Section...

  1. Religiousity, Spirituality and Adolescents' Self-Adjustment

    ERIC Educational Resources Information Center

    Japar, Muhammad; Purwati

    2014-01-01

    Religiuosity, spirituality, and adolescents' self-adjustment. The objective of this study is to test the correlation among religiosity, spirituality and adolescents' self-adjustment. A quantitative approach was employed in this study. Data were collected from 476 junior high schools students of 13 State Junior High Schools and one Junior High…

  2. Adjustable Optical Mount Is More Rigid

    NASA Technical Reports Server (NTRS)

    Asbury, Bill G.; Coombs, David S.; Jones, Irby W.; Moore, Alvah S., Jr.

    1994-01-01

    Improved mount for lens or mirror in laser offers rigidity similar to that of nonadjustable optical mount. In comparison with older adjustable optical mounts, this one less susceptible to movements and distortions caused by vibrations and by thermal expansions and contractions. Mount contains neither adjustment rods (which grow or shrink as temperature varies) nor springs (which transmit vibrations to mounted optic).

  3. 24 CFR 9.155 - Housing adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Housing adjustments. 9.155 Section 9.155 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.155 Housing adjustments. (a) The agency...

  4. 15 CFR 6.6 - Subsequent adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Subsequent adjustments. 6.6 Section 6.6 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION... once every four years after October 23, 1996, make the inflation adjustment, described in Section...

  5. 15 CFR 6.6 - Subsequent adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Subsequent adjustments. 6.6 Section 6.6 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION... once every four years after October 23, 1996, make the inflation adjustment, described in Section...

  6. 15 CFR 6.6 - Subsequent adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Subsequent adjustments. 6.6 Section 6.6 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION... once every four years after October 23, 1996, make the inflation adjustment, described in Section...

  7. 15 CFR 6.6 - Subsequent adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Subsequent adjustments. 6.6 Section 6.6 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION... once every four years after October 23, 1996, make the inflation adjustment, described in Section...

  8. 14 CFR 254.6 - Periodic adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Periodic adjustments. 254.6 Section 254.6 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS DOMESTIC BAGGAGE LIABILITY § 254.6 Periodic adjustments. The Department of Transportation...

  9. Affect and Status Dimensions of Marital Adjustment

    ERIC Educational Resources Information Center

    Fineberg, Beth L.; Joseph Lowman

    1975-01-01

    The interactions of 10 maritally adjusted and 10 maladjusted couples were compared using a coding system based on the Leary circumplex. Major findings are (1) adjusted couples communicated more affection and submission than did maladjusted ones, (2) all couples were more likely to show complementary sequencing patterns with some interesting…

  10. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  11. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  12. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  13. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  14. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  15. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  16. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  17. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  18. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  19. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment... continue to take place based on existing contract/marketing criteria principles....

  20. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment... continue to take place based on existing contract/marketing criteria principles....

  1. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment... continue to take place based on existing contract/marketing criteria principles....

  2. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment... continue to take place based on existing contract/marketing criteria principles....

  3. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment... continue to take place based on existing contract/marketing criteria principles....

  4. Ergonomically Adjustable School Furniture for Male Students

    ERIC Educational Resources Information Center

    Al-Saleh, Khalid S.; Ramadan, Mohamed Z.; Al-Ashaikh, Riyad A.

    2013-01-01

    The need for adjustability in school furniture, in order to accommodate the variation in anthropometric measures of different genders, cultures and ages is becoming increasingly important. Four chair-table combinations, different in dimensions, with adjustable chair seating heights and table heights were designed, manufactured and distributed to…

  5. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... for a contract that otherwise would be approved by RUS. See 7 CFR part 1753. ... 7 Agriculture 11 2011-01-01 2011-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in...

  6. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... for a contract that otherwise would be approved by RUS. See 7 CFR part 1753. ... 7 Agriculture 11 2013-01-01 2013-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in...

  7. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for a contract that otherwise would be approved by RUS. See 7 CFR part 1753. ... 7 Agriculture 11 2014-01-01 2014-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in...

  8. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... for a contract that otherwise would be approved by RUS. See 7 CFR part 1753. ... 7 Agriculture 11 2012-01-01 2012-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in...

  9. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for a contract that otherwise would be approved by RUS. See 7 CFR part 1753. ... 7 Agriculture 11 2010-01-01 2010-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in...

  10. 7 CFR 15b.32 - Academic adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Academic adjustments. 15b.32 Section 15b.32 Agriculture Office of the Secretary of Agriculture NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 15b.32 Academic adjustments. (a) Academic requirements. A recipient...

  11. A Digital Game for International Students' Adjustment

    ERIC Educational Resources Information Center

    Bisadi, Maryam; Chua, Alton Y. K; Keong, Lee Chu

    2013-01-01

    Although digital games have been developed for various subject areas, little attention has been focused on using digital games to address international students' adjustment issues. For this reason, this paper endeavors to explore the use of a digital game in facilitating international students acquire adjustment-related information. Specifically,…

  12. 24 CFR 886.112 - Rent adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Adjustment Factor most recently published by HUD in the Federal Register in accordance with 24 CFR part 888... unassisted housing in the area to ensure that adjustments in the Contract Rents shall not result in material differences between the rents charged for assisted and comparable unassisted units. Contract Rents may...

  13. 24 CFR 886.112 - Rent adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Adjustment Factor most recently published by HUD in the Federal Register in accordance with 24 CFR part 888... unassisted housing in the area to ensure that adjustments in the Contract Rents shall not result in material differences between the rents charged for assisted and comparable unassisted units. Contract Rents may...

  14. 24 CFR 886.112 - Rent adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Adjustment Factor most recently published by HUD in the Federal Register in accordance with 24 CFR part 888... unassisted housing in the area to ensure that adjustments in the Contract Rents shall not result in material differences between the rents charged for assisted and comparable unassisted units. Contract Rents may...

  15. 24 CFR 886.112 - Rent adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Adjustment Factor most recently published by HUD in the Federal Register in accordance with 24 CFR part 888... unassisted housing in the area to ensure that adjustments in the Contract Rents shall not result in material differences between the rents charged for assisted and comparable unassisted units. Contract Rents may...

  16. 24 CFR 886.112 - Rent adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Adjustment Factor most recently published by HUD in the Federal Register in accordance with 24 CFR part 888... unassisted housing in the area to ensure that adjustments in the Contract Rents shall not result in material differences between the rents charged for assisted and comparable unassisted units. Contract Rents may...

  17. 24 CFR 9.155 - Housing adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Housing adjustments. 9.155 Section 9.155 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.155 Housing adjustments. (a) The agency...

  18. 34 CFR 104.44 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Academic adjustments. 104.44 Section 104.44 Education... Postsecondary Education § 104.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure...

  19. 45 CFR 84.44 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Academic adjustments. 84.44 Section 84.44 Public... Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure that such requirements do not...

  20. 45 CFR 605.44 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Academic adjustments. 605.44 Section 605.44 Public... Postsecondary Education § 605.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure...

  1. 7 CFR 15b.32 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Academic adjustments. 15b.32 Section 15b.32... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 15b.32 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to...

  2. 34 CFR 104.44 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Academic adjustments. 104.44 Section 104.44 Education... Postsecondary Education § 104.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure...

  3. 7 CFR 15b.32 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Academic adjustments. 15b.32 Section 15b.32... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 15b.32 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to...

  4. 45 CFR 605.44 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Academic adjustments. 605.44 Section 605.44 Public... Postsecondary Education § 605.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure...

  5. 22 CFR 142.44 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Academic adjustments. 142.44 Section 142.44... OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 142.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make...

  6. 38 CFR 18.444 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Academic adjustments. 18....444 Academic adjustments. (a) Academic requirements. A recipient shall make necessary modifications to its academic requirements to ensure that these requirements do not discriminate or have the effect...

  7. 45 CFR 1170.44 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Academic adjustments. 1170.44 Section 1170.44... ASSISTED PROGRAMS OR ACTIVITIES Postsecondary Education § 1170.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its...

  8. 15 CFR 8b.22 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Academic adjustments. 8b.22 Section 8b... Secondary Education § 8b.22 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure...

  9. 15 CFR 8b.22 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Academic adjustments. 8b.22 Section 8b... Secondary Education § 8b.22 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure...

  10. 22 CFR 217.44 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Academic adjustments. 217.44 Section 217.44... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 217.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make...

  11. 22 CFR 142.44 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Academic adjustments. 142.44 Section 142.44... OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 142.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make...

  12. 45 CFR 1170.44 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Academic adjustments. 1170.44 Section 1170.44... ASSISTED PROGRAMS OR ACTIVITIES Postsecondary Education § 1170.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its...

  13. 38 CFR 18.444 - Academic adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Academic adjustments. 18....444 Academic adjustments. (a) Academic requirements. A recipient shall make necessary modifications to its academic requirements to ensure that these requirements do not discriminate or have the effect...

  14. 45 CFR 84.44 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Academic adjustments. 84.44 Section 84.44 Public... Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make such modifications to its academic requirements as are necessary to ensure that such requirements do not...

  15. 22 CFR 217.44 - Academic adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Academic adjustments. 217.44 Section 217.44... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 217.44 Academic adjustments. (a) Academic requirements. A recipient to which this subpart applies shall make...

  16. Behavioral adjustment of psychiatric hospital patients and helping behavior.

    PubMed

    Tipton, R M; Bland, R E

    1975-03-01

    This study investigated the relationship between behavioral adjustment of mental hospital patients and helping behavior in two distinctly different controlled situations. Forty hospitalized male patients between the ages of 20 and 45 were assigned to two groups of equal size according to ratings they received on the MACC Behavioral Adjustment Scale. Each subject was exposed to two separate and independent experimental situations calling for helping behavior. Helping in the first situation was defined as offering a confederate the use of an extra pencil, while in the second it was defined as offering to help a confederate in the hallway to pick up a box of pencils that had just been dropped. The results of both experiments confirmed the hypothesis that persons suffering more severe levels of disturbance and maladjustment perform significantly fewer helpful acts. Results were discussed in terms of empathy, self-concern, and response cost. Also some implications for treatment were discussed. PMID:1159641

  17. Man-induced channel adjustment in Tennessee streams

    USGS Publications Warehouse

    Robbins, C.H.; Simon, Andrew

    1983-01-01

    Channel modifications in Tennessee, particularly in the western part, have led to large-scale instabilities in the channelized rivers and may have contributed to several bridge failures. These modifications, together with land-use practices, led to downcutting, headward erosion, downstream aggradation, accelerated scour, and bank instabilities. Changes in gradient by channel straightening caused more severe channel response than did dredging or clearing. Large-scale changes continue to occur in all the channelized rivers: the Obion River, its forks, and the South Fork Forked Deer River. However, the non-channelized Hatchie River in west Tennessee not only withstood the natural stresses imposed by the wet years of 1973 to 1975 but continues to exhibit characteristics of stability. Water-surface slope, the primary dependent variable, proved to be a sensitive and descriptive parameter useful in determining channel adjustment. Adjustments to man-induced increases in channel-slope are described by inverse exponential functions of the basic form S=ae(-b(t)); where ' S ' is some function describing channel-slope, ' t ' is the number of years since completion of channel work, and ' a ' and ' b ' are coefficients. Response times for the attainment of ' equilibrium ' channel slopes are a function of the magnitude and extent of the imposed modifications. The adjusted profile gradients attained by the streams following channelization are similar to the predisturbed profile gradients, where no alteration to channel length was made. Where the channels were straightened by constructing cut-offs, thus shortening channel length, then slope adjustments (reduction) proceed past the predisturbed profile gradients, to new profiles with lower gradients. (USGS)

  18. Cross-Cultural Adjustment of Chinese Students in Japan: School Adjustment and Educational Support

    ERIC Educational Resources Information Center

    Li, Yuan Xiang; Sano, Hideki; Ahn, Ruth

    2013-01-01

    This study investigates Chinese immigrant students' cross-cultural and school adjustment issues in Japanese schools. Using a quantitative method, a survey which collected students' demographic information, cross-cultural adjustment, and school adjustment questions was administered to 143 Chinese junior high and high school students in…

  19. 5 CFR 536.305 - Adjusting an employee's retained rate when a pay schedule is adjusted.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Adjusting an employee's retained rate when a pay schedule is adjusted. 536.305 Section 536.305 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS GRADE AND PAY RETENTION Pay Retention § 536.305 Adjusting an employee's retained rate when a pay schedule...

  20. Characterization of neutron-irradiated ferritic model alloys and a RPV steel from combined APT, SANS, TEM and PAS analyses

    NASA Astrophysics Data System (ADS)

    Meslin, E.; Lambrecht, M.; Hernández-Mayoral, M.; Bergner, F.; Malerba, L.; Pareige, P.; Radiguet, B.; Barbu, A.; Gómez-Briceño, D.; Ulbricht, A.; Almazouzi, A.

    2010-11-01

    Understanding the behavior of reactor pressure vessel (RPV) steels under irradiation is a mandatory task that has to be elucidated in order to be able to operate safely a nuclear power plant or to extend its lifetime. To build up predictive tools, a substantial experimental data base is needed at the nanometre scale to extract quantitative information on neutron-irradiated materials and to validate the theoretical models. To reach this experimental goal, ferritic model alloys and French RPV steel were neutron irradiated in a test reactor at an irradiation flux of 9 × 10 17 nm -2 s, doses from 0.18 to 1.3 × 10 24 nm -2 and 300 °C. The main goal of this paper is to report the characterization of the radiation-induced microstructural change in the materials by using the state-of-the-art of characterization techniques available in Europe at the nanometre scale. Possibilities, limitations and complementarities of the techniques to each other are highlighted.

  1. Assessing geomorphic sensitivity in relation to river capacity for adjustment

    NASA Astrophysics Data System (ADS)

    Reid, H. E.; Brierley, G. J.

    2015-12-01

    River sensitivity describes the nature and rate of channel adjustments. An approach to analysis of geomorphic river sensitivity outlined in this paper relates potential sensitivity based on the expected capacity of adjustment for a river type to the recent history of channel adjustment. This approach was trialled to assess low, moderate and high geomorphic sensitivity for four different types of river (10 reaches in total) along the Lower Tongariro River, North Island, New Zealand. Building upon the River Styles framework, river types were differentiated based upon valley setting (width and confinement), channel planform, geomorphic unit assemblages and bed material size. From this, the behavioural regime and potential for adjustment (type and extent) were determined. Historical maps and aerial photographs were geo-rectified and the channel planform digitised to assess channel adjustments for each reach from 1928 to 2007. Floodplain width controlled by terraces, exerted a strong influence upon reach scale sensitivity for the partly-confined, wandering, cobble-bed river. Although forced boundaries occur infrequently, the width of the active channel zone is constrained. An unconfined braided river reach directly downstream of the terrace-confined section was the most geomorphically sensitive reach. The channel in this reach adjusted recurrently to sediment inputs that were flushed through more confined, better connected upstream reaches. A meandering, sand-bed river in downstream reaches has exhibited negligible rates of channel migration. However, channel narrowing in this reach and the associated delta indicate that the system is approaching a threshold condition, beyond which channel avulsion is likely to occur. As this would trigger more rapid migration, this reach is considered to be more geomorphically sensitive than analysis of its low migration rate alone would indicate. This demonstrates how sensitivity is fashioned both by the behavioural regime of a reach

  2. Role of Osmotic Adjustment in Plant Productivity

    SciTech Connect

    Gebre, G.M.

    2001-01-11

    Successful implementation of short rotation woody crops requires that the selected species and clones be productive, drought tolerant, and pest resistant. Since water is one of the major limiting factors in poplar (Populus sp.) growth, there is little debate for the need of drought tolerant clones, except on the wettest of sites (e.g., lower Columbia River delta). Whether drought tolerance is compatible with productivity remains a debatable issue. Among the many mechanisms of drought tolerance, dehydration postponement involves the maintenance of high leaf water potential due to, for example, an adequate root system. This trait is compatible with productivity, but requires available soil moisture. When the plant leaf water potential and soil water content decline, the plant must be able to survive drought through dehydration tolerance mechanisms, such as low osmotic potential or osmotic adjustment. Osmotic adjustment and low osmotic potential are considered compatible with growth and yield because they aid in the maintenance of leaf turgor. However, it has been shown that turgor alone does not regulate cell expansion or stomatal conductance and, therefore, the role of osmotic adjustment is debated. Despite this finding, osmotic adjustment has been correlated with grain yield in agronomic crop species, and gene markers responsible for osmotic adjustment are being investigated to improve drought tolerance in productive progenies. Although osmotic adjustment and low osmotic potentials have been investigated in several forest tree species, few studies have investigated the relationship between osmotic adjustment and growth. Most of these studies have been limited to greenhouse or container-grown plants. Osmotic adjustment and rapid growth have been specifically associated in Populus and black spruce (Picea mariuna (Mill.) B.S.P.) progenies. We tested whether these relationships held under field conditions using several poplar clones. In a study of two hybrid poplar

  3. How should risk adjustment data be collected?

    PubMed

    Kessler, Daniel P

    2012-01-01

    Risk adjustment has broad general application and is a key part of the Patient Protection and Affordable Care Act (ACA). Yet, little has been written on how data required to support risk adjustment should be collected. This paper offers analytical support for a distributed approach, in which insurers retain possession of claims but pass on summary statistics to the risk adjustment authority as needed. It shows that distributed approaches function as well as or better than centralized ones-where insurers submit raw claims data to the risk adjustment authority-in terms of the goals of risk adjustment. In particular, it shows how distributed data analysis can be used to calibrate risk adjustment models and calculate payments, both in theory and in practice--drawing on the experience of distributed models in other contexts. In addition, it explains how distributed methods support other goals of the ACA, and can support projects requiring data aggregation more generally. It concludes that states should seriously consider distributed methods to implement their risk adjustment programs. PMID:22931020

  4. Experiment on performance of adjustable jet pump

    NASA Astrophysics Data System (ADS)

    Zhu, J. M.; Long, X. P.; Zhang, S. B.; Lu, X.

    2012-11-01

    When the water level of upper or lower reaches of hydraulic power station changes, the adjustable jet pump which is different from traditional fixed jet pump can maintain stable pressure and flow rate for the system of technical water supply of hydraulic power plant. The model test indicates that the efficiency of the adjustable jet pump is slightly lower than fixed jet pump near rating operation point. With the decrease of opening degree, both efficiencies are more and more close to each other. The fundamental performance of I-type adjustable jet pump is better than II-type and the cavitation performance of I-type adjustable jet pump is worse than II-type. Test data also indicate that the performance of adjustable jet pump is very different from fixed jet pump, so the theory of fixed jet pump is not able to be copied to adjustable jet pump. It is necessary to farther study on the performance of the adjustable jet pump. This paper has reference value for analogous design of system of circulation water supply to turbine units in hydraulic power station.

  5. Assessing adult adjustment to relationship separation: the Psychological Adjustment to Separation Test (PAST).

    PubMed

    Sweeper, Susie; Halford, Kim

    2006-12-01

    Relationship separation is associated with substantial adult adjustment problems. The Psychological Adjustment to Separation Test (PAST) was developed as a self-report measure of 3 key dimensions of separation adjustment problems: lonely negativity, ex-partner attachment and coparenting conflict. Two independent samples (n = 219 and n = 169, respectively) of recently separated adults, 60% of whom had children, completed the PAST and other measures of general adjustment. Exploratory and confirmatory factor analyses demonstrated a replicable 3-factor structure, with each factor showing satisfactory test-retest and internal reliability and good convergent and discriminant validity. The PAST meets initial criteria for a potentially useful new measure of adult separation adjustment. PMID:17176198

  6. Implementation of Risk Adjustment for Medicare

    PubMed Central

    Ingber, Melvin J.

    2000-01-01

    The Health Care Financing Administration (HCFA) implemented risk adjustment for Medicare capitated organizations January 2000. The risk adjustment system used, the Principal Inpatient Diagnostic Cost Group (PIPDCG) method, had to be incorporated into the payment structure mandated by the Balanced Budget Act of 1997 (BBA). This article describes how risk adjustment was integrated into the payment system within the rules of the BBA, and how fee-for-service (FFS) and health maintenance organization (HMO) data are collected and used in the determination of payment. PMID:11481750

  7. Magnetically Coupled Adjustable Speed Drive Systems

    SciTech Connect

    Chvala, William D.; Winiarski, David W.

    2002-08-18

    Adjustable speed drive (ASD) technologies have the ability to precisely control motor sytems output and produce a numbr of benefits including energy and demand savings. This report examines the performance and cost effectiveness of a specific class of ASDs called magnetically-coupled adjustable speed drives (MC-ASD) which use the strength of a magnetic field to control the amount of torque transferred between motor and drive shaft. The MagnaDrive Adjustable Speed Coupling System uses fixed rare-earth magnets and varies the distance between rotating plates in the assembly. the PAYBACK Variable Speed Drive uses an electromagnet to control the speed of the drive

  8. DAC-3 Pointing Stability Analysis Results for SAGE 3 and Other Users of the International Space Station (ISS) Payload Attachment Sites (PAS)

    NASA Technical Reports Server (NTRS)

    Woods-Vedeler, Jessica A.; Rombado, Gabriel

    1997-01-01

    The purpose of this paper is to provide final results of a pointing stability analysis for external payload attachment sites (PAS) on the International Space Station (ISS). As a specific example, the pointing stability requirement of the SAGE III atmospheric science instrument was examined in this paper. The instrument requires 10 arcsec stability over 2 second periods. SAGE 3 will be mounted on the ISS starboard side at the lower, outboard FIAS. In this engineering analysis, an open-loop DAC-3 finite element model of ISS was used by the Microgravity Group at Johnson Space Flight Center to generate transient responses at PAS to a limited number of disturbances. The model included dynamics up to 50 Hz. Disturbance models considered included operation of the solar array rotary joints, thermal radiator rotary joints, and control moment gyros. Responses were filtered to model the anticipated vibration attenuation effects of active control systems on the solar and thermal radiator rotary joints. A pointing stability analysis was conducted by double integrating acceleration transient over a 2 second period. Results of the analysis are tabulated for ISS X, Y, and Z Axis rotations. These results indicate that the largest excursions in rotation during pointing occurred due to rapid slewing of the thermal radiator. Even without attenuation at the rotary joints, the resulting pointing error was limited to less than 1.6 arcsec. With vibration control at the joints, to a maximum 0.5 arcsec over a 2 second period. Based on this current level of model definition, it was concluded that between 0 - 50 Hz, the pointing stability requirement for SAGE 3 will not be exceeded by the disturbances evaluated in this study.

  9. Prevalence and early attack rate of tuberculosis among close family contacts of tuberculous patients in South India under domiciliary treatment with isoniazid plus PAS or isoniazid alone*

    PubMed Central

    Ramakrishnan, C. V.; Andrews, R. H.; Devadatta, S.; Fox, Wallace; Radhakrishna, S.; Somasundaram, P. R.; Velu, S.

    1961-01-01

    The authors present a report from the Tuberculosis Chemotherapy Centre, Madras, on the prevalence and attack rate of tuberculosis among close family contacts of tuberculous patients in South India undergoing domiciliary chemotherapy either with isoniazid plus PAS or with one of three regimens of isoniazid alone. The report gives (a) the prevalence of tuberculosis among the contacts at the time of diagnosis of the disease in the patients and (b) the incidence of tuberculosis in the contacts during the first year of treatment of the patients. The contacts were divided into four series, corresponding to the four chemotherapeutic regimens of the patients. The prevalence of active tuberculosis was found to be particularly high among children under five years of age, being 12.0% as compared with 7.6% for all age-groups combined. The incidence of active tuberculosis during the year of treatment of the patients was also found to be highest in the under five years' age-group—a further indication that child contacts are especially vulnerable to infection. The incidence was considerably higher in the first quarter of the year than in the other quarters, and it was lowest in the last quarter. This finding, together with the fact that the attack rates in the four contact series were not related either to the duration of bacteriological positivity in the patients or to the period of excretion of isoniazid-resistant organisms by the patients, suggests that the major risk to contacts in the first year results from exposure to the patient before treatment rather than from exposure during treatment. These results thus confirm the findings in an earlier study by the Centre of the contacts of patients in a controlled comparison of chemotherapy with isoniazid plus PAS at home and in sanatorium. PMID:14038589

  10. A PAS domain with an oxygen labile [4Fe-4S](2+) cluster in the oxygen sensor kinase NreB of Staphylococcus carnosus.

    PubMed

    Müllner, Martin; Hammel, Oliver; Mienert, Bernd; Schlag, Steffen; Bill, Eckhard; Unden, Gottfried

    2008-12-30

    The cytoplasmic histidine sensor kinase NreB of Staphylococcus carnosus responds to O(2) and controls together with the response regulator NreC the expression of genes of nitrate/nitrite respiration. nreBC homologous genes were found in Staphylococcus strains and Bacillus clausii, and a modified form was found in some Lactobacillus strains. NreB contains a sensory domain with similarity to heme B binding PAS domains. Anaerobically prepared NreB of S. carnosus exhibited a (diamagnetic) [4Fe-4S](2+) cluster when assessed by Mossbauer spectroscopy. Upon reaction with air, the cluster was degraded with a half-life of approximately 2.5 min. No significant amounts of Mossbauer or EPR detectable intermediates were found during the decay, but magnetic Mossbauer spectra revealed formation of diamagnetic [2Fe-2S](2+) clusters. After extended exposure to air, NreB was devoid of a FeS cluster. Photoreduction with deazaflavin produced small amounts of [4Fe-4S](+), which were degraded subsequently. The magnetically perturbed Mossbauer spectrum of the [4Fe-4S](2+) cluster corroborated the S = 0 spin state and revealed uniform electric field gradient tensors of the iron sites, suggesting full delocalization of the valence electrons and binding of each of the Fe ions by four S ligands, including the ligand to the protein. Mutation of each of the four Cys residues inactivated NreB function in vivo in accordance with their role as ligands. [4Fe-4S](2+) cluster-containing NreB had high kinase activity. Exposure to air decreased the kinase activity and content of the [4Fe-4S](2+) cluster with similar half-lives. We conclude that the sensory domain of NreB represents a new type of PAS domain containing a [4Fe-4S](2+) cluster for sensing and function. PMID:19102705

  11. The Adjustment of New Recruits to Military Life in the Chinese Army: The Longitudinal Predictive Power of MMPI-2

    ERIC Educational Resources Information Center

    Xiao, Lijun; Han, Jing; Han, Jian

    2011-01-01

    In this article, the authors present the findings of two studies analyzing new recruits' adjustment to army life in the Chinese military. In the first exploratory study, we developed a scale to measure new recruits' adjustment to military life, and found that new soldiers' adaptation could be divided into two distinct types: interpersonal…

  12. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  13. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  14. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  15. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  16. Work Adjustment in Employment and Training.

    ERIC Educational Resources Information Center

    Mori, John

    1980-01-01

    Posits that the current CETA program has imposed barriers that oppose the goal of increasing the work capabilities of the participants. Employment and training programs have been improperly designed to deal successfully with those having difficulty with work adjustment. (JOW)

  17. Adjustable throttle linkage for outboard motors

    SciTech Connect

    Dunham, W.D.; Miller, G.L.

    1986-02-17

    An adjustable throttle linkage is described for use in controlling operation of an internal combustion engine having a carburetor including a pivotable throttle valve, a throttle valve position control member operably connected to the throttle valve and movable so as to control the position of the throttle valve, and a throttle lever for controlling the position of the throttle valve. The adjustable throttle linkage comprises a connecting link having one end connected to one of the throttle lever and the control member, and having a threaded portion, means for adjustably connecting the threaded portion to the other of the throttle lever and the control member. The adjustable connecting means includes a slot in the other of the throttle lever and the control member, and a rotatable member threaded onto the threaded portion and receive in the slot such that rotation of the rotatable member causes relative movement between the link and the other of the throttle lever and the control member.

  18. Vietnamese Amerasians: Psychosocial Adjustment and Psychotherapy.

    ERIC Educational Resources Information Center

    Bemak, Fred; Chung, Rita Chi-Ying

    1997-01-01

    Reviews the literature on Amerasians and offers suggestions for directions in psychotherapy. Provides a brief chronology of Amerasian emigration and associated psychological issues, followed by a discussion of myths and generalizations about Amerasians, research findings, and adjustment issues. (RJM)

  19. Risk-adjusted monitoring of survival times

    SciTech Connect

    Sego, Landon H.; Reynolds, Marion R.; Woodall, William H.

    2009-02-26

    We consider the monitoring of clinical outcomes, where each patient has a di®erent risk of death prior to undergoing a health care procedure.We propose a risk-adjusted survival time CUSUM chart (RAST CUSUM) for monitoring clinical outcomes where the primary endpoint is a continuous, time-to-event variable that may be right censored. Risk adjustment is accomplished using accelerated failure time regression models. We compare the average run length performance of the RAST CUSUM chart to the risk-adjusted Bernoulli CUSUM chart, using data from cardiac surgeries to motivate the details of the comparison. The comparisons show that the RAST CUSUM chart is more efficient at detecting a sudden decrease in the odds of death than the risk-adjusted Bernoulli CUSUM chart, especially when the fraction of censored observations is not too high. We also discuss the implementation of a prospective monitoring scheme using the RAST CUSUM chart.

  20. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  1. Overpaying morbidity adjusters in risk equalization models.

    PubMed

    van Kleef, R C; van Vliet, R C J A; van de Ven, W P M M

    2016-09-01

    Most competitive social health insurance markets include risk equalization to compensate insurers for predictable variation in healthcare expenses. Empirical literature shows that even the most sophisticated risk equalization models-with advanced morbidity adjusters-substantially undercompensate insurers for selected groups of high-risk individuals. In the presence of premium regulation, these undercompensations confront consumers and insurers with incentives for risk selection. An important reason for the undercompensations is that not all information with predictive value regarding healthcare expenses is appropriate for use as a morbidity adjuster. To reduce incentives for selection regarding specific groups we propose overpaying morbidity adjusters that are already included in the risk equalization model. This paper illustrates the idea of overpaying by merging data on morbidity adjusters and healthcare expenses with health survey information, and derives three preconditions for meaningful application. Given these preconditions, we think overpaying may be particularly useful for pharmacy-based cost groups. PMID:26420555

  2. Roles of the Pas1 and Par2 genes in determination of the unique, intermediate susceptibility of BALB/cByJ mice to urethane-induction of lung carcinogenesis: differential effects on tumor multiplicity, size and Kras2 mutations.

    PubMed

    Karasaki, H; Obata, M; Ogawa, K; Lee, G H

    1997-10-01

    The C3H/HeJ (C3H), A/J and BALB/cByJ (BALB) mouse strains are respectively resistant, sensitive and intermediate regarding the induction of lung tumors by urethane. The phenotypic difference between C3H and A/J is largely determined by the Pas1 (Pulmonary adenoma susceptibility 1) gene on chromosome 6, the A/J allele of which dominantly increases the tumor burden. We recently found that BALB mice possess a unique lung tumor resistance gene on chromosome 18, designated Par2 (Pulmonary adenoma resistance 2), which partially, but dominantly suppresses the sensitive phenotype of A/J mice (Oncogene 13: 1599-1604, 1996). It has, however, remained unclear why BALB mice carrying the Par2 gene are significantly more sensitive to urethane-induced lung carcinogenesis than C3H mice that have no dominant lung tumor resistance genes. In the present study, using (C3H x BALB)F1 x C3H backcross mice treated with urethane, we demonstrated that BALB mice possess the disease allele of the Pas1 gene despite their 15-fold more resistance relative to A/J mice (LOD = 22.6). The BALB Par2 allele only significantly reduced the mean lung tumor multiplicity (LOD = 4.4) in the backcross population carrying the BALB allele of Pas1, indicating that the intermediate BALB phenotype may at least in part be the result of interactions between these two dominant genes. While the BALB Pas1 allele increased both the mean multiplicity and size of lung tumors, the BALB Par2 allele affected only the mean tumor multiplicity, implying that they are involved in different stages of multi-step lung carcinogenesis. In addition, we found that 68% of lung tumors from the BALB Pas1-positive backcross mice contained activating point mutations of the Kras2 oncogene, tightly linked to the Pas1 locus, whereas these genetic alterations were absent in tumors from BALB Pas1-negative mice. The Par2 genotype exhibited no effect on this parameter. Since the activating point mutations were observed exclusively in the BALB

  3. Adjustable Fiber Optic Microwave Transversal Filters

    NASA Technical Reports Server (NTRS)

    Shadaram, Mehdi; Lutes, George F.; Logan, Ronald T.; Maleki, Lutfollah

    1994-01-01

    Microwave transversal filters implemented as adjustable tapped fiber optic delay lines developed. Main advantages of these filters (in comparison with conventional microwave transversal filters) are small size, light weight, no need for matching of radio-frequency impedances, no need for shielding against electromagnetic radiation at suboptical frequencies, no need for mechanical tuning, high stability of amplitude and phase, and active control of transfer functions. Weights of taps in fiber optic delay lines adjusted.

  4. Adjustable Powder Injector For Vacuum Plasma Sprayer

    NASA Technical Reports Server (NTRS)

    Burns, D. H.; Woodford, W. H.; Mckechnie, T. N.; Mcferrin, D. C.; Davis, W. M.; Beason, G. P., Jr.

    1993-01-01

    Attachment for plasma spray gun provides four degrees of freedom for adjustment of position and orientation at which powder injected externally into plasma flame. Manipulator provides for adjustment of pitch angle of injection tube: set to inject powder at any angle ranging from perpendicular to parallel to cylindrical axis. Scribed lines on extension bar and manipulator indicate pitch angle of extension tube. Collar changed to adapt injector to different gun.

  5. Risk adjustment for pediatric quality indicators.

    PubMed

    Kuhlthau, Karen; Ferris, Timothy G G; Iezzoni, Lisa I

    2004-01-01

    The movement to measure medical care quality has been accelerating, spurred on by evidence of poor quality of care and trials of interventions to improve care. Appropriate measurement of quality of care is an essential aspect of improving the quality of care, yet some quality measures may be influenced by patients' attributes unrelated to quality of care. Risk adjustment is the term commonly applied to those methods that account for patient-related attributes, making measurement of health care quality as comparable as possible across providers or organizations seeing different mixes of patients. The measurement of quality of care for children poses specific challenges. In addition to these measurement challenges, analysts must ensure that quality comparisons among doctors, groups of doctors, hospitals, or health plans are not adversely affected by the likelihood that different types of patients seek care in different places. Although some techniques designed to adjust performance measures for case mix were developed for both adults and children, other systems are specific to childhood circumstances. The theoretical issues involved in risk-adjusting childhood outcomes measures for newborns in the neonatal intensive care unit were reviewed recently. Here, we go beyond the neonatal intensive care unit setting to consider risk adjustment for pediatric quality measures more broadly. In particular, we 1) review the conceptual background for risk-adjusting quality measures, 2) present policy issues related to adjusting pediatric quality measures, and 3) catalog existing risk-adjustment methodologies for pediatric quality measures. We conclude with an overall assessment of the status of risk adjustment for pediatric quality measures and recommendations for additional research and application. PMID:14702503

  6. [Design of an adjustable simulated lung].

    PubMed

    Xu, Liang; Luo, Zhe

    2011-03-01

    We designed an adjustable simulated lung for clinical use. Depending on the feature of adjustable resistance and compliance, the device could simulate various pathological changes of lung, such as obstructive diseases and restrictive diseases. Thru simulating various pathological conditions with the device, the clinicians could learn how to manipulate a mechanical ventilator. In addition, the device has a leakage equipment for simulating leakage of respiratory circuit, depending on which the clinicians could learn more about ventilators. PMID:21706793

  7. Dyadic Adjustment and Spiritual Activities in Parents of Children with Cystic Fibrosis

    PubMed Central

    Grossoehme, Daniel H.; Szczesniak, Rhonda; Dodd, Caitlin; Opipari-Arrigan, Lisa

    2015-01-01

    Children’s diseases can negatively impact marital adjustment and contribute to poorer child health outcomes. To cope with increased marital stress and childhood diseases severity, many people turn to spirituality. While most studies show a positive relationship between spirituality and marital adjustment, spirituality has typically been measured only in terms of individual behaviors. Using the Dyadic Adjustment Scale (DAS) and Daily Phone Diary data from a sample of 126 parents of children with cystic fibrosis as a context for increased marital stress, spiritual behavior of mother-father dyads and of whole families were used as predictors of marital adjustment. Frequency and duration of individual, dyadic and familial spiritual activities correlated positively with dyadic adjustment. Significant differences in spiritual activities existed between couples with marital adjustment scores above and below the cutoff for distress. The only significant factors in regressions of spiritual activities on marital adjustment scores were number of pulmonary exacerbations and parent age. Higher odds of maintaining a marital adjustment score greater than 100 were significantly associated with spending approximately twelve minutes per day in individual, but not conjugal or familial, spiritual activities. The Daily Phone Diary is a feasible tool to study conjugal and familial activities and their relationships with beliefs and attitudes, including spirituality. PMID:26900486

  8. Structureless Bundle Adjustment with Self-Calibration Using Accumulated Constraints

    NASA Astrophysics Data System (ADS)

    Cefalu, A.; Haala, N.; Fritsch, D.

    2016-06-01

    Bundle adjustment based on collinearity is the most widely used optimization method within image based scene reconstruction. It incorporates observed image coordinates, exterior and intrinsic camera parameters as well as object space coordinates of the observed points. The latter dominate the resulting nonlinear system, in terms of the number of unknowns which need to be estimated. In order to reduce the size of the problem regarding memory footprint and computational effort, several approaches have been developed to make the process more efficient, e.g. by exploitation of sparsity or hierarchical subdivision. Some recent developments express the bundle problem through epipolar geometry and scale consistency constraints which are free of object space coordinates. These approaches are usually referred to as structureless bundle adjustment. The number of unknowns in the resulting system is drastically reduced. However, most work in this field is focused on optimization towards speed and considers calibrated cameras, only. We present our work on structureless bundle adjustment, focusing on precision issues as camera calibration and residual weighting. We further investigate accumulation of constraint residuals as an approach to decrease the number of rows of the Jacobian matrix.

  9. Adjustment of geochemical background by robust multivariate statistics

    USGS Publications Warehouse

    Zhou, D.

    1985-01-01

    Conventional analyses of exploration geochemical data assume that the background is a constant or slowly changing value, equivalent to a plane or a smoothly curved surface. However, it is better to regard the geochemical background as a rugged surface, varying with changes in geology and environment. This rugged surface can be estimated from observed geological, geochemical and environmental properties by using multivariate statistics. A method of background adjustment was developed and applied to groundwater and stream sediment reconnaissance data collected from the Hot Springs Quadrangle, South Dakota, as part of the National Uranium Resource Evaluation (NURE) program. Source-rock lithology appears to be a dominant factor controlling the chemical composition of groundwater or stream sediments. The most efficacious adjustment procedure is to regress uranium concentration on selected geochemical and environmental variables for each lithologic unit, and then to delineate anomalies by a common threshold set as a multiple of the standard deviation of the combined residuals. Robust versions of regression and RQ-mode principal components analysis techniques were used rather than ordinary techniques to guard against distortion caused by outliers Anomalies delineated by this background adjustment procedure correspond with uranium prospects much better than do anomalies delineated by conventional procedures. The procedure should be applicable to geochemical exploration at different scales for other metals. ?? 1985.

  10. Perceived nativeness and sensitivity to temporal adjustments in speech

    NASA Astrophysics Data System (ADS)

    Wang, Yue; Behne, Dawn M.

    2005-04-01

    Native Mandarin Chinese speakers productions of English consonant-vowel (CV) syllables have shown syllable-internal temporal adjustments in the direction of native (English)-like CVs (Wang and Behne, 2004). The current study presents two experiments investigating whether these temporal adjustments affect perceived nativeness. For three production types (native-English, Chinese productions of English, native-Chinese), three syllable-internal timing patterns (English-like, Chinese-English-like, Chinese-like) were applied, resulting in nine stimuli types. Native English listeners judged how English-like each stimulus was on a 7-point scale. In the first experiment, production-types and timing patterns were randomized. Results show that listeners can reliably identify nativeness of the three productions, with Chinese productions of English perceived as intermediate to the native Chinese and native American English productions. Listeners also showed a tendency toward using timing within the CV to identify nativeness. In the second experiment the same materials were therefore blocked by production type. Results reveal the perceptual saliency of the temporal adjustments in nonnative productions. These findings support a view of L2 acquisition as a gradual process toward the target L2 (e.g., Caramazza et al., 1973). The current study extends this view, showing evidence that listeners can perceive the inter-language system, bearing the nature of both L1 and L2.

  11. The static contribution of Glacial Isostatic Adjustment on the Geoid

    NASA Astrophysics Data System (ADS)

    Metivier, L.; Greff-Lefftz, M.

    2012-04-01

    The Glacial Isostatic Adjustment (GIA) is due to the unloading of ice on the Earth surface following the last deglaciation period a few thousand years ago. The ice mass redistributions induce an adjustment of the planet. Following this adjustment, there are viscoelastic deformations of the solid Earth, sea level rise, gravity variations, geocenter motions, and also disruption of the Earth's rotation. We investigate here the present-day impact of GIA on the "static" component of the geoid. It is well known that GIA processes induce slow time variations of the gravity and the geoid shape. The total accumulation of the geoid changes since the beginning of the last deglaciation induces a total geoid perturbation that seems today constant in time at the human time scale. We want here to infer precisely the magnitude of this constant component in order to construct a GIA free-geoid. We tested different GIA models and tested different Earth viscosity profiles. We show that the GIA induces a constant perturbation of the geoid that can be quite important over North America and Scandinavia regions, depending on Earth models.

  12. [Weight-for-height in adults: comparison of classifications adjusted and non adjusted by frame size].

    PubMed

    Hernández Hernández, R A; Hernández de Valera, Y

    1998-03-01

    The present study is to analyze the concordance, agreements and divergence of anthropometry nutritional classification of weight-height (WH) in adults, using criteria that include frame size adjustments and no adjustment at all. 224 adults were studied (127 female and 117 males) from the "Simón Bolívar" University Administrative Employees Health Project, 1993. Using as basis, the variables weight, height, wrist circumference and elbow breadth, we determined: a) frame size by wrist circumference methods (WC) (Grant, 1980) and elbow breadth (EB) (Frame index 2 by Frisancho, 1989); b) classification by weight-height (WH) according to table by frame size (Frisancho, 1984). 57%, 38% and 6% corresponded to small, medium and large frame sizes, by WC. 16%, 60% and 25% by EB. When classifying by WH those results showed differences between 16-25% in female and 15-21% in males. When contrasting the three criteria, it was observed a bigger coincidence between WH without frame size adjustment and WH adjustment by EB. The smallest coincidence between WH adjusted by WC method and weight height without frame size adjustment in the whole group, while male and female got the biggest coincidence in WH adjustment by WC and HW without frame size adjustment. The smallest concordance (k = 0.37) was obtained when contrasting WH frame size adjustment by EB vs weight-height without adjustment in female, and biggest concordance (k = 0.60) when contrasting WH by WC and without adjustment in males. This results show that, there are significative differences in nutritional classification of weight-height in adults adjusted and non adjusted by frame size within the same group of persons. PMID:9754399

  13. Personal Adjustment Training for the Spinal Cord Injured

    ERIC Educational Resources Information Center

    Roessler, Richard; And Others

    1976-01-01

    This article describes experiences with Personal Achievement Skills (PAS), a group counseling process in a spinal cord injury project, emphasizing training in communication and goal setting in the context of group process. Issues in conducting such training and providing comprehensive service to the spinal cord injured are discussed in detail.…

  14. Linguistic Indicators of Patient, Couple, and Family Adjustment following Breast Cancer

    PubMed Central

    Robbins, Megan L.; Mehl, Matthias R.; Smith, Hillary L.; Weihs, Karen L.

    2012-01-01

    Introduction This study examined how language reflective of emotional and social processes during a cancer-related discussion relates to patient, couple, and family adjustment after breast cancer. It investigated whether emotional expression or relational focus, manifested in language use, indicates healthy family coping following breast cancer. Methods Family members each completed measures of adjustment (Family Environment Scale, Dyadic Adjustment Scale, and patient Profile of Mood States), and engaged in a 15-minute family discussion about how they have coped with breast cancer. Transcripts from the discussion were submitted to a text-analysis software program to obtain frequency of positive and negative emotion words, and personal pronouns spoken by each family member. The relationship between self-reports of adjustment and frequency of language use during the family discussion was analyzed with regression models. Results Partners’ positive emotion words were indicative of better family adjustment, patients’ negative emotion words indicated greater family conflict, and sons’ and daughters’ anger words indicated poorer adjustment, whereas their anxiety words indicated better family adjustment. Partner we-talk was related to better dyadic adjustment, and couples’ “you” was somewhat related to worse adjustment at all levels. Conclusions/Implications Important information about how a family copes with breast cancer can be obtained by attending to families’ emotional and relational language. This study suggests that clinicians and members of families’ support networks can gauge how well a family has adapted after the breast cancer experience by attending to the type of words that each family member uses to describe how they coped with breast cancer. PMID:22887054

  15. Advance and prospectus of seasonal prediction: assessment of the APCC/CliPAS 14-model ensemble retrospective seasonal prediction (1980-2004)

    NASA Astrophysics Data System (ADS)

    Wang, Bin; Lee, June-Yi; Kang, In-Sik; Shukla, J.; Park, C.-K.; Kumar, A.; Schemm, J.; Cocke, S.; Kug, J.-S.; Luo, J.-J.; Zhou, T.; Wang, B.; Fu, X.; Yun, W.-T.; Alves, O.; Jin, E. K.; Kinter, J.; Kirtman, B.; Krishnamurti, T.; Lau, N. C.; Lau, W.; Liu, P.; Pegion, P.; Rosati, T.; Schubert, S.; Stern, W.; Suarez, M.; Yamagata, T.

    2009-07-01

    We assessed current status of multi-model ensemble (MME) deterministic and probabilistic seasonal prediction based on 25-year (1980-2004) retrospective forecasts performed by 14 climate model systems (7 one-tier and 7 two-tier systems) that participate in the Climate Prediction and its Application to Society (CliPAS) project sponsored by the Asian-Pacific Economic Cooperation Climate Center (APCC). We also evaluated seven DEMETER models’ MME for the period of 1981-2001 for comparison. Based on the assessment, future direction for improvement of seasonal prediction is discussed. We found that two measures of probabilistic forecast skill, the Brier Skill Score (BSS) and Area under the Relative Operating Characteristic curve (AROC), display similar spatial patterns as those represented by temporal correlation coefficient (TCC) score of deterministic MME forecast. A TCC score of 0.6 corresponds approximately to a BSS of 0.1 and an AROC of 0.7 and beyond these critical threshold values, they are almost linearly correlated. The MME method is demonstrated to be a valuable approach for reducing errors and quantifying forecast uncertainty due to model formulation. The MME prediction skill is substantially better than the averaged skill of all individual models. For instance, the TCC score of CliPAS one-tier MME forecast of Niño 3.4 index at a 6-month lead initiated from 1 May is 0.77, which is significantly higher than the corresponding averaged skill of seven individual coupled models (0.63). The MME made by using 14 coupled models from both DEMETER and CliPAS shows an even higher TCC score of 0.87. Effectiveness of MME depends on the averaged skill of individual models and their mutual independency. For probabilistic forecast the CliPAS MME gains considerable skill from increased forecast reliability as the number of model being used increases; the forecast resolution also increases for 2 m temperature but slightly decreases for precipitation. Equatorial Sea Surface

  16. 38 CFR 10.0 - Adjusted service pay entitlements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Adjusted service pay... COMPENSATION Adjusted Compensation; General § 10.0 Adjusted service pay entitlements. A veteran entitled to adjusted service pay is one whose adjusted service credit does not amount to more than $50 as...

  17. 38 CFR 10.0 - Adjusted service pay entitlements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Adjusted service pay... COMPENSATION Adjusted Compensation; General § 10.0 Adjusted service pay entitlements. A veteran entitled to adjusted service pay is one whose adjusted service credit does not amount to more than $50 as...

  18. Predicting Eating Disorder Continuum Groups: Hardiness and College Adjustment.

    ERIC Educational Resources Information Center

    Simon-Boyd, Gail D.; Bieschke, Kathleen J.

    This study examined relationships between hardiness, college adjustment (academic adjustment, social adjustment, personal-emotional adjustment, institutional attachment) and eating disorder (ED) continuum categories in 122 female and 20 male college students. Students who exhibited a higher level of personal-emotional adjustment (PEA) to college…

  19. 42 CFR 422.310 - Risk adjustment data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Risk adjustment data. 422.310 Section 422.310... Organizations § 422.310 Risk adjustment data. (a) Definition of risk adjustment data. Risk adjustment data are all data that are used in the development and application of a risk adjustment payment model. (b)...

  20. 13 CFR 315.16 - Adjustment proposal requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF COMMERCE TRADE ADJUSTMENT ASSISTANCE FOR FIRMS Adjustment Proposals § 315.16 Adjustment proposal... reasonably calculated to contribute materially to the economic adjustment of the Firm (i.e., that such... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Adjustment proposal...

  1. 42 CFR 422.310 - Risk adjustment data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Risk adjustment data. 422.310 Section 422.310... Organizations § 422.310 Risk adjustment data. (a) Definition of risk adjustment data. Risk adjustment data are all data that are used in the development and application of a risk adjustment payment model. (b)...

  2. 42 CFR 422.310 - Risk adjustment data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Risk adjustment data. 422.310 Section 422.310....310 Risk adjustment data. (a) Definition of risk adjustment data. Risk adjustment data are all data that are used in the development and application of a risk adjustment payment model. (b)...

  3. ITRF2008 solution, geodetic parameters and Glacial Isostatic Adjustment

    NASA Astrophysics Data System (ADS)

    Metivier, L.; Collilieux, X.; Greff-Lefftz, M.; Altamimi, Z.

    2011-12-01

    Glacial Isostatic Adjustment (GIA) leads to long term crust motion, gravity variation, sea level rise and perturbation of Earth rotation. Recent studies have enlightened unexpected differences between a few recent GIA models mostly due to the way GIA induced rotational feedback is modeled. The validity and quality of these models have been essentially discussed with respect to space gravity observations. Here, we investigate what information the up-to-date International Terrestrial Reference Frame solution, ITRF2008, provides on large scale geodetic observables and by extension on Glacial Isostatic Adjustment (GIA) and recent ice melting processes. We particularly focus on the GNSS network of ITRF2008 solution because of the present day high precision of GNSS technique and because of the good density of the GNSS network. From these data, we infer and study large scale geodetic parameters and their time evolutions, such as Earth oblateness and J2 rate, or secular rotational feedback. We also investigate different GIA and recent ice melting models.

  4. Future trends in adjustable speed drives

    SciTech Connect

    Murphy, H.G.

    1995-12-31

    Adjustable speed drives are an evolving technology stimulated by the demand for improved process control and tempered by environmental conditions--an evolution controlled by the dynamics of electrical power, power devices and traditional control methods. How these factors interact controls future trends and product offerings for a variety of adjustable speed motor controllers. With the topic of adjustable speed motor controllers` a reasonable place to start would be with the motor. Although many types of motors can be used for variable speed applications, this paper will focus on the ac motor and the electronic controllers associated with ac motors. Both frequency and voltage are controllable motor parameters. Controlling either or both can improve the performance of the ac motor within a given application. Each type of controller offers a unique set of advantages and disadvantages, however, the simultaneous control of frequency and voltage provides the greatest benefits. The adjustable speed controller that provides simultaneous control of frequency and voltage for ac motors is the AFD or adjustable frequency drive.

  5. Urinary arsenic concentration adjustment factors and malnutrition.

    PubMed

    Nermell, Barbro; Lindberg, Anna-Lena; Rahman, Mahfuzar; Berglund, Marika; Persson, Lars Ake; El Arifeen, Shams; Vahter, Marie

    2008-02-01

    This study aims at evaluating the suitability of adjusting urinary concentrations of arsenic, or any other urinary biomarker, for variations in urine dilution by creatinine and specific gravity in a malnourished population. We measured the concentrations of metabolites of inorganic arsenic, creatinine and specific gravity in spot urine samples collected from 1466 individuals, 5-88 years of age, in Matlab, rural Bangladesh, where arsenic-contaminated drinking water and malnutrition are prevalent (about 30% of the adults had body mass index (BMI) below 18.5 kg/m(2)). The urinary concentrations of creatinine were low; on average 0.55 g/L in the adolescents and adults and about 0.35 g/L in the 5-12 years old children. Therefore, adjustment by creatinine gave much higher numerical values for the urinary arsenic concentrations than did the corresponding data expressed as microg/L, adjusted by specific gravity. As evaluated by multiple regression analyses, urinary creatinine, adjusted by specific gravity, was more affected by body size, age, gender and season than was specific gravity. Furthermore, urinary creatinine was found to be significantly associated with urinary arsenic, which further disqualifies the creatinine adjustment. PMID:17900556

  6. Topics in data adjustment theory and applications

    SciTech Connect

    Hwang, R.N.

    1988-01-01

    The methodologies of the uncertainty analysis and data adjustment have been well-developed and widely used abroad since the early 70's. With limited amount of covariance data on the differential cross section and the integral experiments available at the time, their accomplishments are, indeed, astounding. The fundamental adjustment equations, however, remain qualitatively unchanged. For the past few year, extensive efforts on these subjects have also begun at ANL in order to utilize the massive amount of integral experiments accumulated over years to provide the basis for improving the reactor parameters encountered in various design calculations. Pertinent covariance matrices and sensitivity matrices of the existing integral experiments have been evaluated and systematically compiled in the data files along with the cross section covariance data derived from the ENDF-B/V for the 21 group structure currently under consideration. A production code GMADJ that provides the adjusted quantities for a large number of cross section types has been developed by Poenitz for routine applications. The primary purpose of the present paper is to improve understanding of the application oriented issues important to the data adjustment theory and the subsequent usage of the adjusted quantities in the design calculations in support of these activities. 30 refs., 12 figs., 5 tabs.

  7. Energetics of geostrophic adjustment in rotating flow

    NASA Astrophysics Data System (ADS)

    Juan, Fang; Rongsheng, Wu

    2002-09-01

    Energetics of geostrophic adjustment in rotating flow is examined in detail with a linear shallow water model. The initial unbalanced flow considered first falls tinder two classes. The first is similar to that adopted by Gill and is here referred to as a mass imbalance model, for the flow is initially motionless but with a sea surface displacement. The other is the same as that considered by Rossby and is referred to as a momentum imbalance model since there is only a velocity perturbation in the initial field. The significant feature of the energetics of geostrophic adjustment for the above two extreme models is that although the energy conversion ratio has a large case-to-case variability for different initial conditions, its value is bounded below by 0 and above by 1 / 2. Based on the discussion of the above extreme models, the energetics of adjustment for an arbitrary initial condition is investigated. It is found that the characteristics of the energetics of geostrophic adjustment mentioned above are also applicable to adjustment of the general unbalanced flow under the condition that the energy conversion ratio is redefined as the conversion ratio between the change of kinetic energy and potential energy of the deviational fields.

  8. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  9. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  10. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  11. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  12. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  13. Religiosity and Psychosocial Adjustment Among 100 Homng Refugees.

    PubMed

    Westermeyer, Joseph; Nugent, Sean

    1994-01-01

    PURPOSE OF THE PAPER. The purpose of this paper is to study the relationship between religiosity and psychosocial adjustment in a group of Asian refugees from Laos. SUMMARY OF METHODS UTILIZED. Subjects consisted of 100 adult Hmong refugees from Laos who had relocated one decade earlier to Minnesota. At the time of the interview, about 80% remained in Minnesota; the remainder were interviewed in their respective communities. Five measures of religiosity were operationalized: Religious Belief (animism versus monotheism); recent Religious Practice (present/absent in previous monthrpar;; Religious Conversion lpar;present/absent in the U.S.rpar;; having a Home Altar (present/absent today); and having a shamanistic Trance Ritual (present/absent in the last five years). These five indices of religiosity were then compared against four general areas of psychosocial adaptation as follows: demographic characteristics lpar;5 itemsrpar;; sociocultural indices of adaptation lpar;5 items, including 2 scales) health care seeking over the previous five years (6 items); and psychiatric signs and symptoms (4 psychiatric scales). SUMMARY OF METHODS UTILIZED. Methods of data collection were as follows: (1) questionnaire-based interviewing by Hmong research assistants to provide data on religion affiliation, belief and practice; demographic information; psychosocial function; cultural affiliations and behaviors; and health care seeking; (2rpar; a psychiatric interview by the senior author followed by completion of two psychosocial scales (Axis 4 Psychosocial Stressors and Axis 5 Psychosocial Function using DSM-III criteriarpar; and several psychiatric rating scales lpar;Hamilton Anxiety Scale, Hamilton Depression Scale, Brief Psychiatric Rating Scale, and Global Assessment Scalerpar;. PRINCIPAL FINDINGS. Religious Pracitice in the last month was highly associated with several measures of psychosocial adaptation. Conversely, any Trance Ritual in the last five years was associated

  14. Role of a Conserved Salt Bridge between the PAS Core and the N-Terminal Domain in the Activation of the Photoreceptor Photoactive Yellow Protein

    PubMed Central

    Hoersch, Daniel; Otto, Harald; Joshi, Chandra P.; Borucki, Berthold; Cusanovich, Michael A.; Heyn, Maarten P.

    2007-01-01

    The effect of ionic strength on the conformational equilibrium between the I2 intermediate and the signaling state I2′ of the photoreceptor PYP and on the rate of recovery to the dark state were investigated by time-resolved absorption and fluorescence spectroscopy. With increasing salt concentration up to ∼600 mM, the recovery rate k3 decreases and the I2/I2′ equilibrium (K) shifts in the direction of I2′. At higher ionic strength both effects reverse. Experiments with mono-(KCl, NaBr) and divalent (MgCl2, MgSO4) salts show that the low salt effect depends on the ionic strength and not on the cation or anion species. These observations can be described over the entire ionic strength range by considering the activity coefficients of an interdomain salt bridge. At low ionic strength the activity coefficient decreases due to counterion screening whereas at high ionic strength binding of water by the salt leads to an increase in the activity coefficient. From the initial slopes of the plots of log k3 and log K versus the square root of the ionic strength, the product of the charges of the interacting groups was found to be −1.3 ± 0.2, suggesting a monovalent ion pair. The conserved salt bridge K110/E12 connecting the β-sheet of the PAS core and the N-terminal domain is a prime candidate for this ion pair. To test this hypothesis, the mutants K110A and E12A were prepared. In K110A the salt dependence of the I2/I2′ equilibrium was eliminated and of the recovery rate was greatly reduced below ∼600 mM. Moreover, at low salt the recovery rate was six times slower than in wild-type. In E12A significant salt dependence remained, which is attributed to the formation of a novel salt bridge between K110 and E9. At high salt reversal occurs in both mutants suggesting that salting out stabilizes the more compact I2 structure. However, chaotropic anions like SCN shift the I2/I2′ equilibrium toward the partially unfolded I2′ form. The salt linkage K110/E12

  15. 45 CFR 153.350 - Risk adjustment data validation standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT State Standards Related to the Risk Adjustment Program § 153.350 Risk adjustment...

  16. 45 CFR 153.350 - Risk adjustment data validation standards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK ADJUSTMENT UNDER THE AFFORDABLE CARE ACT State Standards Related to the Risk Adjustment Program § 153.350 Risk adjustment...

  17. 26 CFR 1.803-2 - Adjusted reserves.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) INCOME TAXES Life Insurance Companies § 1.803-2 Adjusted reserves. For the purpose of determining... insurance, no adjustment is to be made. The reserves are thus adjusted, and the rate of interest on...

  18. 45 CFR 153.350 - Risk adjustment data validation standards.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... implementation of any risk adjustment software and ensure proper validation of a statistically valid sample of... respect to implementation of risk adjustment software or as a result of data validation conducted pursuant... implementation of risk adjustment software or data validation....

  19. 75 FR 16575 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board. ACTION: Adoption of a railroad cost recovery procedures productivity adjustment. SUMMARY... productivity adjustment, as measured by the average change in railroad productivity for the years 2004...

  20. The variance of the adjusted Rand index.

    PubMed

    Steinley, Douglas; Brusco, Michael J; Hubert, Lawrence

    2016-06-01

    For 30 years, the adjusted Rand index has been the preferred method for comparing 2 partitions (e.g., clusterings) of a set of observations. Although the index is widely used, little is known about its variability. Herein, the variance of the adjusted Rand index (Hubert & Arabie, 1985) is provided and its properties are explored. It is shown that a normal approximation is appropriate across a wide range of sample sizes and varying numbers of clusters. Further, it is shown that confidence intervals based on the normal distribution have desirable levels of coverage and accuracy. Finally, the first power analysis evaluating the ability to detect differences between 2, different adjusted Rand indices is provided. (PsycINFO Database Record PMID:26881693

  1. Methods for automatic trigger threshold adjustment

    DOEpatents

    Welch, Benjamin J; Partridge, Michael E

    2014-03-18

    Methods are presented for adjusting trigger threshold values to compensate for drift in the quiescent level of a signal monitored for initiating a data recording event, thereby avoiding false triggering conditions. Initial threshold values are periodically adjusted by re-measuring the quiescent signal level, and adjusting the threshold values by an offset computation based upon the measured quiescent signal level drift. Re-computation of the trigger threshold values can be implemented on time based or counter based criteria. Additionally, a qualification width counter can be utilized to implement a requirement that a trigger threshold criterion be met a given number of times prior to initiating a data recording event, further reducing the possibility of a false triggering situation.

  2. Optical phantoms with adjustable subdiffusive scattering parameters.

    PubMed

    Krauter, Philipp; Nothelfer, Steffen; Bodenschatz, Nico; Simon, Emanuel; Stocker, Sabrina; Foschum, Florian; Kienle, Alwin

    2015-10-01

    A new epoxy-resin-based optical phantom system with adjustable subdiffusive scattering parameters is presented along with measurements of the intrinsic absorption, scattering, fluorescence, and refractive index of the matrix material. Both an aluminium oxide powder and a titanium dioxide dispersion were used as scattering agents and we present measurements of their scattering and reduced scattering coefficients. A method is theoretically described for a mixture of both scattering agents to obtain continuously adjustable anisotropy values g between 0.65 and 0.9 and values of the phase function parameter γ in the range of 1.4 to 2.2. Furthermore, we show absorption spectra for a set of pigments that can be added to achieve particular absorption characteristics. By additional analysis of the aging, a fully characterized phantom system is obtained with the novelty of g and γ parameter adjustment. PMID:26473589

  3. Micro Ring Grating Spectrometer with Adjustable Aperture

    NASA Technical Reports Server (NTRS)

    Park, Yeonjoon (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor); Choi, Sang H. (Inventor)

    2012-01-01

    A spectrometer includes a micro-ring grating device having coaxially-aligned ring gratings for diffracting incident light onto a target focal point, a detection device for detecting light intensity, one or more actuators, and an adjustable aperture device defining a circular aperture. The aperture circumscribes a target focal point, and directs a light to the detection device. The aperture device is selectively adjustable using the actuators to select a portion of a frequency band for transmission to the detection device. A method of detecting intensity of a selected band of incident light includes directing incident light onto coaxially-aligned ring gratings of a micro-ring grating device, and diffracting the selected band onto a target focal point using the ring gratings. The method includes using an actuator to adjust an aperture device and pass a selected portion of the frequency band to a detection device for measuring the intensity of the selected portion.

  4. Optical phantoms with adjustable subdiffusive scattering parameters

    NASA Astrophysics Data System (ADS)

    Krauter, Philipp; Nothelfer, Steffen; Bodenschatz, Nico; Simon, Emanuel; Stocker, Sabrina; Foschum, Florian; Kienle, Alwin

    2015-10-01

    A new epoxy-resin-based optical phantom system with adjustable subdiffusive scattering parameters is presented along with measurements of the intrinsic absorption, scattering, fluorescence, and refractive index of the matrix material. Both an aluminium oxide powder and a titanium dioxide dispersion were used as scattering agents and we present measurements of their scattering and reduced scattering coefficients. A method is theoretically described for a mixture of both scattering agents to obtain continuously adjustable anisotropy values g between 0.65 and 0.9 and values of the phase function parameter γ in the range of 1.4 to 2.2. Furthermore, we show absorption spectra for a set of pigments that can be added to achieve particular absorption characteristics. By additional analysis of the aging, a fully characterized phantom system is obtained with the novelty of g and γ parameter adjustment.

  5. Choosing a standard for adjusted mortality rates.

    PubMed

    Seltzer, F

    1996-01-01

    For over half a century, the standard for age-adjustment in mortality studies has been based on the total population according to the 1940 census. The question periodically arises, however, whether a more recent census population might now be more appropriate. Thus, a study using the six censuses from 1940 to 1990 was conducted to see the effect each of these populations would have on the age-adjusted (standardized) death rates. While the size of the age-adjusted rates was affected by the censal standard populations from 1940 to 1990, these populations hardly changed the proportional mortality by age, sex, cause-of-death and geographic area. It appears that a shift from the 1940 standard will not be necessary, although if more detailed comparisons are needed, age-specific death rates can always be used. The 1940 standard also has the advantage of being consistent with many earlier studies. PMID:8744891

  6. Psychosocial adjustment to ALS: a longitudinal study

    PubMed Central

    Matuz, Tamara; Birbaumer, Niels; Hautzinger, Martin; Kübler, Andrea

    2015-01-01

    For the current study the Lazarian stress-coping theory and the appendant model of psychosocial adjustment to chronic illness and disabilities (Pakenham, 1999) has shaped the foundation for identifying determinants of adjustment to ALS. We aimed to investigate the evolution of psychosocial adjustment to ALS and to determine its long-term predictors. A longitudinal study design with four measurement time points was therefore, used to assess patients' quality of life, depression, and stress-coping model related aspects, such as illness characteristics, social support, cognitive appraisals, and coping strategies during a period of 2 years. Regression analyses revealed that 55% of the variance of severity of depressive symptoms and 47% of the variance in quality of life at T2 was accounted for by all the T1 predictor variables taken together. On the level of individual contributions, protective buffering, and appraisal of own coping potential accounted for a significant percentage in the variance in severity of depressive symptoms, whereas problem management coping strategies explained variance in quality of life scores. Illness characteristics at T2 did not explain any variance of both adjustment outcomes. Overall, the pattern of the longitudinal results indicated stable depressive symptoms and quality of life indices reflecting a successful adjustment to the disease across four measurement time points during a period of about two years. Empirical evidence is provided for the predictive value of social support, cognitive appraisals, and coping strategies, but not illness parameters such as severity and duration for adaptation to ALS. The current study contributes to a better conceptualization of adjustment, allowing us to provide evidence-based support beyond medical and physical intervention for people with ALS. PMID:26441696

  7. A Comparison of the Structural Factors of the Propensity for Abusiveness Scale for Women and Men in a Domestic Violence Treatment Program.

    PubMed

    Allen, Christopher T; Swan, Suzanne C; Maas, Carl D; Barber, Sara

    2015-08-01

    Court-mandated domestic violence (DV) treatment programs across the country have seen a marked increase in female clients. These programs use a variety of measurement tools to assess the needs of their clients. Increased numbers of women in treatment for DV reflect a need to address the measurement of intimate partner violence (IPV) for both males and females. Unfortunately, the reliability and validity of many of measures used to assess IPV and related constructs for women remains unknown. The current study focuses on a particular measure, the Propensity for Abusiveness Scale (PAS). The PAS is not a measure of abusive behavior per se; rather, it assesses risk factors for abuse, including affective lability, anger expression, trauma symptoms, and harsh parenting experienced by the respondent. Specifically, the current study compares the factor structure and the measurement properties of the PAS for males and females in a sample of 885 (647 female, 238 male) participants in a DV treatment program. Findings indicate that the PAS demonstrated configural, metric, and scalar invariance between the female and male samples. These results suggest that it is appropriate for researchers and clinicians to make comparisons between women and men based on PAS factor scores. PMID:25304668

  8. Carburetion system including an adjustable throttle linkage

    SciTech Connect

    Du Bois, C.G.; Falig, J.D.

    1986-03-25

    A throttle linkage assembly is described comprising a throttle shaft rotatable about a throttle shaft axis between an idle position and a wide open throttle position, a throttle plate fixed on the throttle shaft, a driven lever pivotable about the throttle shaft axis between various angles relative to the throttle plate, and means for fixing the driven lever at a selected angle relative to the throttle plate an adjustment lever fixedly connected to the throttle adjacent the driven lever, and means for releasably securing the driven lever to the adjustment lever.

  9. Adjusting learning motivation to promote cooperation

    NASA Astrophysics Data System (ADS)

    Zhang, Haifeng; Small, Michael; Yang, Hanxin; Wang, Binghong

    2010-11-01

    An evolutionary prisoner’s dilemma game with players adjusting their learning motivation is studied. At each time step, each player can adjust his/her learning motivation according to the difference between the current payoff and payoff aspiration. Greater payoff aspiration means stronger learning motivation, and vice versa. We find that the density of cooperation in a spatial prisoner’s dilemma game is enhanced when the learning motivation mechanism is considered. Meanwhile, we show that proper noise can not only induce the highest cooperation level but also can maintain the cooperation phenomenon even though there is more temptation to defect.

  10. Risk adjustment for a children's capitation rate.

    PubMed

    Newhouse, J P; Sloss, E M; Manning, W G; Keeler, E B

    1993-01-01

    Few capitation arrangements vary premiums by a child's health characteristics, yielding an incentive to discriminate against children with predictably high expenditures from chronic diseases. In this article, we explore risk adjusters for the 35 percent of the variance in annual out-patient expenditure we find to be potentially predictable. Demographic factors such as age and gender only explain 5 percent of such variance; health status measures explain 25 percent, prior use and health status measures together explain 65 to 70 percent. The profit from risk selection falls less than proportionately with improved ability to adjust for risk. Partial capitation rates may be necessary to mitigate skimming and dumping. PMID:10133708

  11. Self-Adjusting Liquid Injectors for Combustors

    NASA Technical Reports Server (NTRS)

    Trinh, Huu; Myers, William

    2010-01-01

    A class of self-adjusting injectors for spraying liquid oxidizers and/or fuels into combustion chambers has been proposed. The proposed injectors were originally intended for use in rocket-engine combustion chambers, but could also be used to improve control over flows of liquid propellants in other combustion chambers. The basic idea of the proposed injectors is to use simple mechanisms, inside the injectors themselves, to adjust inlet areas so as to keep injection pressure drops at or near optimum values through out wide throttling ranges. These mechanisms would be actuated by the very pressure drops that they are intended to regulate.

  12. Adjustment enhancer or moderator? The role of resilience in postmigration filial responsibility.

    PubMed

    Ponizovsky-Bergelson, Yael; Kurman, Jenny; Roer-Strier, Dorit

    2015-06-01

    The current study investigated resilience factors in filial responsibility and their relationships to adjustment indicators. Young adult immigrants from the former Soviet Union to Israel (N = 220) completed the Comprehensive Filial Responsibilities Inventory and 4 proxy measures of adjustment: An adapted version of the Brief Symptom Inventory, the Satisfaction With Life Scale, the General Self-Efficacy Scale, and selected items from the General Life Functioning Inventory. The resilience factors examined included individual characteristics of Sense of Coherence, Optimism, and perceived social support from an adapted version of the Multidimensional Scale of Perceived Social Support. In general, the resilience factors diminished the relationship between filial responsibility and some of the adjustment indicators. Overall, resilience factors make a strong and meaningful contribution to young immigrants' adjustment when main effects are considered. However, the resilience factors did not moderate the effect of filial responsibility in a protective way. The results contribute to an understanding of interrelations between postmigration filial responsibility and adjustment. Implications for social and clinical work with young-adult immigrants who have experienced filial responsibility in their family of origin are addressed. PMID:25844490

  13. Early Environmental Support and Elementary School Adjustment as Predictors of School Adjustment in Middle Adolescence.

    ERIC Educational Resources Information Center

    Carlson, Elizabeth A.; Sroufe, L. Alan; Collins, W. Andres; Jimerson, Shane; Weinfield, Nancy; Henninghausen, Katherine; Egeland, Byron; Hyson, Daniel M.; Anderson, Fione; Meyer, Stephanie E.

    1999-01-01

    This longitudinal study examined socioemotional antecedents of adolescent school adjustment. Findings indicated that early and later parental problem-solving support accounted for 13 percent of variance in high school adjustment. Early and later parental problem-solving support, peer competence, externalizing behavior, and emotional…

  14. Pairwise agonist scanning-flow cytometry (PAS-FC) measures inside-out signaling and patient-specific response to combinatorial platelet agonists.

    PubMed

    Jaeger, Daniel T L; Diamond, Scott L

    2013-05-01

    Understanding the response of cells to multiple stimuli is vital for predicting donor specific responses and better understanding the signaling pathways involved. This is of particular importance in platelets because exposure of phosphatidylserine (PS) occurs upon costimulation but not with a single agonist. Here, we describe a multiplexed pairwise agonist scanning-flow cytometry (PAS-FC) method of measuring platelet inside-out responses to all pairs of six platelet agonists (convulxin, SFLLRN, AYPGKF, ADP, U46619, and PGE(2)) used at their EC(50) concentrations. These agonists allowed exploration of platelet signaling downstream of GPVI, PAR-1, PAR-4, P2Y(1), P2Y(12), TP, and IP receptors. The three-color flow cytometry method simultaneously measured integrin α(IIb)β(3) activation with PAC-1 antibody, P-selectin exposure (via α granule release) with anti-P-selectin, and PS exposure with annexin V. These responses were consistent across a healthy male donor pool. In duplicate measurements with each donor, 4 of the 10 donors had a sufficiently unique 45-parameter (15 pairs × 3 colors) phenotype to self-cluster (P < 0.001). This method has the potential for efficiently scanning for patient specific responses across a broad agonist-receptor space. PMID:23662898

  15. Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli

    PubMed Central

    Johnson, Matthew D; Bell, James; Clarke, Kim; Chandler, Rachel; Pathak, Prachi; Xia, Yandong; Marshall, Robert L; Weinstock, George M; Loman, Nicholas J; Winn, Peter J; Lund, Peter A

    2014-01-01

    Laboratory-based evolution and whole-genome sequencing can link genotype and phenotype. We used evolution of acid resistance in exponential phase Escherichia coli to study resistance to a lethal stress. Iterative selection at pH 2.5 generated five populations that were resistant to low pH in early exponential phase. Genome sequencing revealed multiple mutations, but the only gene mutated in all strains was evgS, part of a two-component system that has already been implicated in acid resistance. All these mutations were in the cytoplasmic PAS domain of EvgS, and were shown to be solely responsible for the resistant phenotype, causing strong upregulation at neutral pH of genes normally induced by low pH. Resistance to pH 2.5 in these strains did not require the transporter GadC, or the sigma factor RpoS. We found that EvgS-dependent constitutive acid resistance to pH 2.5 was retained in the absence of the regulators GadE or YdeO, but was lost if the oxidoreductase YdeP was also absent. A deletion in the periplasmic domain of EvgS abolished the response to low pH, but not the activity of the constitutive mutants. On the basis of these results we propose a model for how EvgS may become activated by low pH. PMID:24995530

  16. Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.

    PubMed

    Bersten, David C; Bruning, John B; Peet, Daniel J; Whitelaw, Murray L

    2014-01-01

    Neuronal Per-Arnt-Sim homology (PAS) Factor 4 (NPAS4) is a neuronal activity-dependent transcription factor which heterodimerises with ARNT2 to regulate genes involved in inhibitory synapse formation. NPAS4 functions to maintain excitatory/inhibitory balance in neurons, while mouse models have shown it to play roles in memory formation, social interaction and neurodegeneration. NPAS4 has therefore been implicated in a number of neuropsychiatric or neurodegenerative diseases which are underpinned by defects in excitatory/inhibitory balance. Here we have explored a broad set of non-synonymous human variants in NPAS4 and ARNT2 for disruption of NPAS4 function. We found two variants in NPAS4 (F147S and E257K) and two variants in ARNT2 (R46W and R107H) which significantly reduced transcriptional activity of the heterodimer on a luciferase reporter gene. Furthermore, we found that NPAS4.F147S was unable to activate expression of the NPAS4 target gene BDNF due to reduced dimerisation with ARNT2. Homology modelling predicts F147 in NPAS4 to lie at the dimer interface, where it appears to directly contribute to protein/protein interaction. We also found that reduced transcriptional activation by ARNT2 R46W was due to disruption of nuclear localisation. These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation and have potential implications for cognitive phenotypic variation and diseases such as autism, schizophrenia and dementia. PMID:24465693

  17. Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function

    PubMed Central

    Bersten, David C.; Bruning, John B.; Peet, Daniel J.; Whitelaw, Murray L.

    2014-01-01

    Neuronal Per-Arnt-Sim homology (PAS) Factor 4 (NPAS4) is a neuronal activity-dependent transcription factor which heterodimerises with ARNT2 to regulate genes involved in inhibitory synapse formation. NPAS4 functions to maintain excitatory/inhibitory balance in neurons, while mouse models have shown it to play roles in memory formation, social interaction and neurodegeneration. NPAS4 has therefore been implicated in a number of neuropsychiatric or neurodegenerative diseases which are underpinned by defects in excitatory/inhibitory balance. Here we have explored a broad set of non-synonymous human variants in NPAS4 and ARNT2 for disruption of NPAS4 function. We found two variants in NPAS4 (F147S and E257K) and two variants in ARNT2 (R46W and R107H) which significantly reduced transcriptional activity of the heterodimer on a luciferase reporter gene. Furthermore, we found that NPAS4.F147S was unable to activate expression of the NPAS4 target gene BDNF due to reduced dimerisation with ARNT2. Homology modelling predicts F147 in NPAS4 to lie at the dimer interface, where it appears to directly contribute to protein/protein interaction. We also found that reduced transcriptional activation by ARNT2 R46W was due to disruption of nuclear localisation. These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation and have potential implications for cognitive phenotypic variation and diseases such as autism, schizophrenia and dementia. PMID:24465693

  18. Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall’s Tau*

    PubMed Central

    Zhu, Wensheng; Jiang, Yuan; Zhang, Heping

    2012-01-01

    Identifying the risk factors for comorbidity is important in psychiatric research. Empirically, studies have shown that testing multiple, correlated traits simultaneously is more powerful than testing a single trait at a time in association analysis. Furthermore, for complex diseases, especially mental illnesses and behavioral disorders, the traits are often recorded in different scales such as dichotomous, ordinal and quantitative. In the absence of covariates, nonparametric association tests have been developed for multiple complex traits to study comorbidity. However, genetic studies generally contain measurements of some covariates that may affect the relationship between the risk factors of major interest (such as genes) and the outcomes. While it is relatively easy to adjust these covariates in a parametric model for quantitative traits, it is challenging for multiple complex traits with possibly different scales. In this article, we propose a nonparametric test for multiple complex traits that can adjust for covariate effects. The test aims to achieve an optimal scheme of adjustment by using a maximum statistic calculated from multiple adjusted test statistics. We derive the asymptotic null distribution of the maximum test statistic, and also propose a resampling approach, both of which can be used to assess the significance of our test. Simulations are conducted to compare the type I error and power of the nonparametric adjusted test to the unadjusted test and other existing adjusted tests. The empirical results suggest that our proposed test increases the power through adjustment for covariates when there exist environmental effects, and is more robust to model misspecifications than some existing parametric adjusted tests. We further demonstrate the advantage of our test by analyzing a data set on genetics of alcoholism. PMID:22745516

  19. Risk-Adjusted Models for Adverse Obstetric Outcomes and Variation in Risk Adjusted Outcomes Across Hospitals

    PubMed Central

    Bailit, Jennifer L.; Grobman, William A.; Rice, Madeline Murguia; Spong, Catherine Y.; Wapner, Ronald J.; Varner, Michael W.; Thorp, John M.; Leveno, Kenneth J.; Caritis, Steve N.; Shubert, Phillip J.; Tita, Alan T. N.; Saade, George; Sorokin, Yoram; Rouse, Dwight J.; Blackwell, Sean C.; Tolosa, Jorge E.; Van Dorsten, J. Peter

    2014-01-01

    Objective Regulatory bodies and insurers evaluate hospital quality using obstetrical outcomes, however meaningful comparisons should take pre-existing patient characteristics into account. Furthermore, if risk-adjusted outcomes are consistent within a hospital, fewer measures and resources would be needed to assess obstetrical quality. Our objective was to establish risk-adjusted models for five obstetric outcomes and assess hospital performance across these outcomes. Study Design A cohort study of 115,502 women and their neonates born in 25 hospitals in the United States between March 2008 and February 2011. Hospitals were ranked according to their unadjusted and risk-adjusted frequency of venous thromboembolism, postpartum hemorrhage, peripartum infection, severe perineal laceration, and a composite neonatal adverse outcome. Correlations between hospital risk-adjusted outcome frequencies were assessed. Results Venous thromboembolism occurred too infrequently (0.03%, 95% CI 0.02% – 0.04%) for meaningful assessment. Other outcomes occurred frequently enough for assessment (postpartum hemorrhage 2.29% (95% CI 2.20–2.38), peripartum infection 5.06% (95% CI 4.93–5.19), severe perineal laceration at spontaneous vaginal delivery 2.16% (95% CI 2.06–2.27), neonatal composite 2.73% (95% CI 2.63–2.84)). Although there was high concordance between unadjusted and adjusted hospital rankings, several individual hospitals had an adjusted rank that was substantially different (as much as 12 rank tiers) than their unadjusted rank. None of the correlations between hospital adjusted outcome frequencies was significant. For example, the hospital with the lowest adjusted frequency of peripartum infection had the highest adjusted frequency of severe perineal laceration. Conclusions Evaluations based on a single risk-adjusted outcome cannot be generalized to overall hospital obstetric performance. PMID:23891630

  20. Health and health expenditures in adjusting and non-adjusting countries.

    PubMed

    van der Gaag, J; Barham, T

    1998-04-01

    The focus of this study is on the impact of World Bank structural adjustment operations on health expenditures and outcomes. We compare trends and levels of real per capita public spending on health, private consumption (which is the resource base for private health expenditures), and groupings child mortality indicators in four groups of countries. These are: (i) countries that started to borrow for the adjustment process early--Early Adjustment Lending (EAL) countries, (ii) Other Adjustment Lending (OAL) countries, (iii) Non-Adjustment Lending countries whose economies grew during the period 1985-1990 (NAL+), and (iv) Non-Adjustment Lending countries whose economies did not grow (NAL-). The NAL- group provides a 'counterfactual' for comparison with the two groups of adjusting countries. The results show that the fear about possible declines in health care spending in adjusting countries is unwarranted for EAL countries, that is those countries that started the adjustment process early and took it seriously. Government spending on health care increased on average for this group of countries, as did private consumption levels. Government health care expenditures also continued to increase in OAL countries, but mixed GDP growth performance has left little room for increased private spending. However, those countries that showed negative growth in the late eighties and did not start an adjustment process, fared worse throughout: real per capita public health care spending declined during the late eighties and increased less than in the other countries during 1989-1993, while private consumption has declined steadily. The trends in child mortality indicators show tremendous and continuing progress during the past two or three decades with few discernible differences among the four country groupings. PMID:9579751