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Sample records for adjustment scale pas

  1. Validity of the Premorbid Adjustment Scale

    PubMed Central

    Brill, N.; Reichenberg, A.; Weiser, M.; Rabinowitz, J.

    2008-01-01

    Background: The aim of the current study was to test the predictive and concurrent validity of the Premorbid Adjustment Scale (PAS) by comparing it with another similar but more elaborate retrospective measure and with data collected during late adolescence. Methods: We compared PAS late adolescence scores (age 16–18 years) of 91 males with schizophrenia or schizoaffective disorder with data on behavior collected in adolescence, before the first psychotic episode as part of standardized Draft Board screening, and with the same measure readministered during adulthood and modified to collect the same data again retrospectively. Results: The correlation of the PAS social withdrawal and social relations items with the social behavior scale of the Draft Board were .76 and .80, respectively, for the concurrent ratings and .52 and .53, respectively, for the data collected at age 17 years. The correlation of the PAS school achievements and school adjustment items with the functioning in structured environments scale of the Draft Board were .71 and .72, respectively, for the concurrent ratings and .43 and .47, respectively, for the data collected at age 17 years. Conclusions: Our results support the predictive and concurrent validity of the PAS and the validity of self-reported data on premorbid functioning in persons with schizophrenia. PMID:18032397

  2. Multi-Scale 7DOF View Adjustment.

    PubMed

    Cho, Isaac; Li, Jialei; Wartell, Zachary

    2017-02-13

    Multi-scale virtual environments contain geometric details ranging over several orders of magnitude and typically employ out-of-core rendering techniques. When displayed in virtual reality systems this entails using a 7 degree-of-freedom (DOF) view model where view scale is a separate 7th DOF in addition to 6DOF view pose. Dynamic adjustment of this and other view parameters become very important to usability. In this paper, we evaluate how two adjustment techniques interact with uni- and bi-manual 7 degree-of-freedom navigation in DesktopVR and a CAVE. The travel task has two stages, an initial targeted zoom and a detailed geometric inspection. The results show benefits of the auto-adjustments on completion time and stereo fusion issues, but only in certain circumstances. Peculiar view configuration examples show the difficulty of creating robust adjustment rules.

  3. Adjustments to the ICVGT scale of INRIM

    NASA Astrophysics Data System (ADS)

    Steur, P. P. M.; Giraudi, D.

    2013-09-01

    At the 8th Temperature Symposium the results have been presented for the Interpolating Constant Volume Gas thermometer at INRIM (then IMGC), featuring a cryogenic pressure transducer, with an expanded uncertainty of less then 1.5 mK. However, for its fixed points this scale still relied on a NPL calibration as carried by rhodium-iron thermometer 232324. After the clarification, in 2005, by the Consultative Committee on Thermometry (CCT) of the definition of the equilibrium hydrogen (e-H2) triple point this scale was due to be adjusted for the isotopic content in the e-H2 fixed point cell. Only when this thermometer was re-calibrated in 2010 at INRIM at the three fixed points of the ICVGT was this adjustment performed, being the isotopic composition of the hydrogen cell known. With the start of the Neon Project in 2005, it became clear that a second adjustment would soon be needed, once the CCT will have decided on the way to deal with the isotopic composition of neon. The paper presents the experimental data of 2010, discusses the stability of the thermometer, and the size of the correction at the hydrogen point and of the likely correction (and its uncertainty) to be applied to the neon point, the isotopic composition of this cell being known as well.

  4. Adjustments to the ICVGT scale of INRIM

    SciTech Connect

    Steur, P. P. M.; Giraudi, D.

    2013-09-11

    At the 8{sup th} Temperature Symposium the results have been presented for the Interpolating Constant Volume Gas thermometer at INRIM (then IMGC), featuring a cryogenic pressure transducer, with an expanded uncertainty of less then 1.5 mK. However, for its fixed points this scale still relied on a NPL calibration as carried by rhodium-iron thermometer 232324. After the clarification, in 2005, by the Consultative Committee on Thermometry (CCT) of the definition of the equilibrium hydrogen (e-H2) triple point this scale was due to be adjusted for the isotopic content in the e-H2 fixed point cell. Only when this thermometer was re-calibrated in 2010 at INRIM at the three fixed points of the ICVGT was this adjustment performed, being the isotopic composition of the hydrogen cell known. With the start of the Neon Project in 2005, it became clear that a second adjustment would soon be needed, once the CCT will have decided on the way to deal with the isotopic composition of neon. The paper presents the experimental data of 2010, discusses the stability of the thermometer, and the size of the correction at the hydrogen point and of the likely correction (and its uncertainty) to be applied to the neon point, the isotopic composition of this cell being known as well.

  5. Family Adjustment Measure: Scale Construction and Validation

    ERIC Educational Resources Information Center

    Daire, Andrew P.; Dominguez, Vanessa N.; Carlson, Ryan G.; Case-Pease, Jenene

    2014-01-01

    We administered the Family Adjustment Measure to 368 parents of children with special needs to identify positive adjustment. We randomly split the sample to conduct exploratory factor analysis ("n" = 194) and confirmatory factor analysis ("n" = 174). Results indicated four possible subscales and that explain 51% of the variance.

  6. Polyacene (PAS) batteries

    SciTech Connect

    Yata, Shizukuni

    1995-12-31

    Human activity has been recognized to seriously influence the earth`s environment. Therefore, a clean battery with long-life and safe-use is important and its demand has increased at present. Of the ``clean`` batteries proposed, polymer batteries are the best candidate for environment-friendly and highly-reliable because they do not contain a toxic heavy metal such as cadmium and mercury. The author has developed polyacenic semiconductor (PAS) materials prepared from pyrolytic treatment of phenol-formaldehyde resin. PAS is a conductive polymer which can be doped to either P-type or N-type quite successfully and is extremely resistant to oxidation, chemicals and heat. Because PAS can be doped with both electron acceptors and donors, it is possible to design an all polymer battery using PAS for both electrodes. By taking advantage of stability of PAS, PAS battery can embody greater and longer-lasting reliability than conventional secondary batteries. Usually, lithium metal, which is used in the lithium secondary batteries for an anode-active material, makes dendrites during charging/discharging cycles, which limits the life of the batteries to a few dozen cycles. Furthermore, the dendrites of lithium metal have a safety problem because of its reactivity with water. An investigation of a new anode-material aiming to replace the lithium metal with another safety electrode, is one of the major trend, in secondary batteries. In this paper, the author first describes the structure and the properties of the PAS material, and second its application as an electrode material for rechargeable batteries.

  7. Factorial invariance of the Dyadic Adjustment Scale across gender.

    PubMed

    South, Susan C; Krueger, Robert F; Iacono, William G

    2009-12-01

    The Dyadic Adjustment Scale (DAS; G. B. Spanier, 1976) is the most widely used inventory of relationship satisfaction in the social sciences, yet the question of whether it is measuring the same concept in men and women has never been addressed. In the current study, the authors examined the factor structure of the DAS in a sample of 900 currently married couples who participated in the Minnesota Twin Family Study. Confirmatory factor analysis was applied to a second-order factor solution with Spanier's four factors (Dyadic Consensus, Dyadic Satisfaction, Dyadic Cohesion, Affectional Expression) loading on one higher order factor (Relationship Adjustment), to test for measurement invariance across gender. The second-order solution was relatively invariant across gender, even when taking into account the nonindependent nature of the data. This suggests that the best conceptualization of the DAS is one of a gender-invariant measure of marital adjustment with four distinct subfactors and that differences between men and women on any of these constructs can be interpreted by both clinicians and researchers as true mean differences rather than measurement bias.

  8. The feasibility and application of gray scale adjustment method in high temperature digital image correlation

    NASA Astrophysics Data System (ADS)

    Wang, Shen; Yao, Xue Feng; Su, Yun Quan; Liu, Wei

    2017-02-01

    In this paper, the basic principle and application of linear gray scale adjustment method are investigated in high temperature digital image correlation (DIC) technology. First, the simple linear gray scale adjustment method is proposed, which can adjust the gray scale value of the saturated pixels and diminish the correlation error caused by the saturated pixels. Then, both the simulated high temperature images and DIC correlation results before and after the gray scale adjustment are provided and analyzed to verify its effectiveness, in which the displacement error decreased from 0.1 pixels to 0.04 pixels after the linear gray scale adjustment for high temperature images. Finally, the linear gray scale adjustment method is used to extract the displacement with high accuracy in high temperature experiment of SiC specimen, and the displacement error decreased from 0.5 pixels to 0.1 pixels after the linear gray scale adjustment.

  9. Detecting Anchoring-and-Adjusting in Survey Scales

    ERIC Educational Resources Information Center

    McIntyre, Joe

    2014-01-01

    Proper survey design is essential to obtain reliable, replicable data from research subjects. One threat to inferences drawn from surveys is anchoring-and-adjusting. Tversky and Kahnemann (1974) observed that participants' responses to questions depended systematically on irrelevant information they received prior to answering. It is important for…

  10. Continued growth for military PAs.

    PubMed

    Salyer, Steven W

    2002-10-01

    The US military physician assistant (PA) originated from the corpsmen and medics of the army, navy, air force, and Coast Guard. PAs have been present in every military campaign since 1980 and serve in a wide variety of medical roles. Their combat role has expanded so that in many instances the PA has replaced the physician as the front-line care provider. All have moved from warrant officer into the commissioned officer ranks, a change that has enabled them to rise into command and administrative positions. Narrowing of the pay differential between military and civilian PAs has contributed to their retention.

  11. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate weights, repairs, adjustments or replacements after inspection. (a) All scales used by stockyard owners,...

  12. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection. (a) All scales used to determine the net weight of meat...

  13. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection. (a) All scales used to determine the net weight of meat...

  14. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate weights, repairs, adjustments or replacements after inspection. (a) All scales used by stockyard owners,...

  15. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection. (a) All scales used to determine the net weight of meat...

  16. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection. (a) All scales used to determine the net weight of meat...

  17. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate weights, repairs, adjustments or replacements after inspection. (a) All scales used by stockyard owners,...

  18. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate weights, repairs, adjustments or replacements after inspection. (a) All scales used by stockyard owners,...

  19. 9 CFR 201.71 - Scales; accurate weights, repairs, adjustments or replacements after inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scales; accurate weights, repairs... AGRICULTURE REGULATIONS UNDER THE PACKERS AND STOCKYARDS ACT Services § 201.71 Scales; accurate weights, repairs, adjustments or replacements after inspection. (a) All scales used by stockyard owners,...

  20. 9 CFR 442.3 - Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Scale requirements for accurate... PROCEDURES AND REQUIREMENTS FOR ACCURATE WEIGHTS § 442.3 Scale requirements for accurate weights, repairs, adjustments, and replacements after inspection. (a) All scales used to determine the net weight of meat...

  1. Measuring Dyadic Adjustment: New Scales for Assessing the Quality of Marriage and Similar Dyads

    ERIC Educational Resources Information Center

    Spanier, Graham B.

    1976-01-01

    This study reports on the development of the Dyadic Adjustment Scale, a new measure for assessing the quality of marriage and other similar dyads. This factor analytic study suggests four empirically verified components of dyadic adjustment to be used as subscales (dyadic satisfaction, dyadic cohesion, dyadic consensus and affectional expression).…

  2. Dysbindin (DTNBP1, 6p22.3) is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS)

    ERIC Educational Resources Information Center

    Gornick, M. C.; Addington, A. M.; Sporn, A.; Gogtay, N.; Greenstein, D.; Lenane, M.; Gochman, P.; Ordonez, A.; Balkissoon, R.; Vakkalanka, R.; Weinberger, D. R.; Rapoport, J. L.; Straub, R. E.

    2005-01-01

    Straub "et al." ("2002") recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid…

  3. iPAS Propulsion Subsystem

    NASA Technical Reports Server (NTRS)

    Sanchez, Rodrigo

    2011-01-01

    The ultimate goal of the Integrated Power, Avionics and Software (iPAS) project is to develop a simulation facility that can be apply to various missions that use common avionics, hardware, and software architecture. The iPAS facility will model several subsystems, the EP4 contribution to the project is to design and build a low fidelity representation of the in-space propulsion system for the iPAS simulation. The system would use a pressurized bottle to provide the gas for the thrusters. Air will be used to perform the simulation to prevent a hazardous environment in the facility. Three cold gas thrusters previously used for the X-38 program will be used for the simulation because they are on hand and available for use. An incremental design-build-test approach will be taken where the X-38 thrusters may be replaced with actual flight thrusters as the flight design is matured. A pressurized system must be designed, built, and tested to reduce the 2,400psi bottle pressure to a reasonable pressure (0-800psig) to minimize the amount of noise created upon thruster activation. Once all the subsystems are completed they will be integrated together for testing.

  4. Development and Validation of Social Provision Scale on First Year Undergraduate Psychological Adjustment

    ERIC Educational Resources Information Center

    Oluwatomiwo, Oladunmoye Enoch

    2015-01-01

    This study examined the development and validation of socio provision scale on first year undergraduates adjustment among institution in Ibadan metropolis. The study adopted a descriptive survey design. A sample of 300 participants was randomly selected across institutions in Ibadan. Data were collected using socio provision scale (a =0.76),…

  5. The Tenacious Goal Pursuit and Flexible Goal Adjustment Scales: Examination of Their Validity

    ERIC Educational Resources Information Center

    Mueller, Daniel J.; Kim, Kyung

    2004-01-01

    This study tested the unidimensionality of the Tenacious Goal Pursuit (TGP) and Flexible Goal Adjustment (FGA) scales and examined the relationships of the factors measured in these scales with two criterion constructs (happiness and self-acceptance) and with age in a sample 292 adults (ranging from 50 to 90 years). Confirmatory factor analyses…

  6. Ford Partnership for Advanced Studies (Ford PAS)

    ERIC Educational Resources Information Center

    Carrier, Cheryl

    2006-01-01

    This article features the Ford Partnership for Advanced Studies (Ford PAS) program that helps students gain knowledge about real-life business issues. Ford PAS is an educational program that combines college-prep academics with the critical 21st century skills students will need to succeed in college and in the workplace. The Ford PAS program uses…

  7. Adjustment Scales for Children and Adolescents: Factorial Validity in a Canadian Sample

    ERIC Educational Resources Information Center

    Canivez, Gary L.; Beran, Tanya N.

    2009-01-01

    The core syndrome factor structure of the Adjustment Scales for Children and Adolescents (ASCA) was examined with a sample of 375 randomly selected Canadian youths in a large western city. The 6 ASCA core syndrome raw scores produced an identical two-factor solution as observed in samples of American youths. Principal axis exploratory factor…

  8. Adjustment Scales for Children and Adolescents and Native American Indians: Factorial Validity Generalization for Ojibwe Youths

    ERIC Educational Resources Information Center

    Canivez, Gary L.

    2006-01-01

    Replication of the core syndrome factor structure of the "Adjustment Scales for Children and Adolescents" (ASCA; P.A. McDermott, N.C. Marston, & D.H. Stott, 1993) is reported for a sample of 183 Native American Indian (Ojibwe) children and adolescents from North Central Minnesota. The six ASCA core syndromes produced an identical…

  9. Evaluation of a New Mean Scaled and Moment Adjusted Test Statistic for SEM

    ERIC Educational Resources Information Center

    Tong, Xiaoxiao; Bentler, Peter M.

    2013-01-01

    Recently a new mean scaled and skewness adjusted test statistic was developed for evaluating structural equation models in small samples and with potentially nonnormal data, but this statistic has received only limited evaluation. The performance of this statistic is compared to normal theory maximum likelihood and 2 well-known robust test…

  10. Replication of the Adjustment Scales for Children and Adolescents Core Syndrome Factor Structure

    ERIC Educational Resources Information Center

    Canivez, Gary L.

    2004-01-01

    Independent examination and replication of the core syndrome factor structure of the Adjustment Scales for Children and Adolescents (ASCA; McDermott, Marston, & Stott, 1993) is reported. A sample of 1,020 children were randomly selected from their classroom and rated on the ASCA by their teacher. The six ASCA core syndromes produced a…

  11. Trinidad and Tobago National Standardization of the Adjustment Scales for Children and Adolescents

    ERIC Educational Resources Information Center

    McDermott, Paul A.; Watkins, Marley W.; Rhoad, Anna M.; Chao, Jessica L.; Worrell, Frank C.; Hall, Tracey E.

    2015-01-01

    Given relevant cultural distinctions across nations, it is important to determine the dimensional structure and normative characteristics of psychological assessment devices in each focal population. This article examines the national standardization and validation of the Adjustment Scales for Children and Adolescents (ASCA) with a nationally…

  12. Spatial scale of local breeding habitat quality and adjustment of breeding decisions.

    PubMed

    Doligez, Blandine; Berthouly, Anne; Doligez, Damien; Tanner, Marion; Saladin, Verena; Bonfils, Danielle; Richner, Heinz

    2008-05-01

    Experimental studies provide evidence that, in spatially and temporally heterogeneous environments, individuals track variation in breeding habitat quality to adjust breeding decisions to local conditions. However, most experiments consider environmental variation at one spatial scale only, while the ability to detect the influence of a factor depends on the scale of analysis. We show that different breeding decisions by adults are based on information about habitat quality at different spatial scales. We manipulated (increased or decreased) local breeding habitat quality through food availability and parasite prevalence at a small (territory) and a large (patch) scale simultaneously in a wild population of Great Tits (Parus major). Females laid earlier in high-quality large-scale patches, but laying date did not depend on small-scale territory quality. Conversely, offspring sex ratio was higher (i.e., biased toward males) in high-quality, small-scale territories but did not depend on large-scale patch quality. Clutch size and territory occupancy probability did not depend on our experimental manipulation of habitat quality, but territories located at the edge of patches were more likely to be occupied than central territories. These results suggest that integrating different decisions taken by breeders according to environmental variation at different spatial scales is required to understand patterns of breeding strategy adjustment.

  13. The social adjustment scale-self-report: psychometric properties for older adults.

    PubMed

    Zweig, Richard A; Turkel, Elihu

    2007-12-01

    To assess the reliability and validity of the Social Adjustment Scale-Self-Report for older adults, 129 community dwelling elderly ranging in age from 63 to 87 years (M=72.3 yr., SD=5.0) were surveyed using a modified version of the scale. The average internal consistency of subscales was satisfactory (mean coefficient alpha=.62). Overall social functioning impairment (total score) was associated with measures of depression (Beck Depression Inventory, r =.58) and global psychiatric symptoms (Brief Symptom Inventory, r = .55). Older adults scored higher on Marital role, Family Unit role, and overall social functioning impairment compared to mixed-age adults assessed in previous research, and higher on marital role impairment but similarly on overall social functioning when compared with a mixed-age sample from primary care. The modified Social Adjustment Scale-Self-Report has acceptable psychometric characteristics for research use with older adults, and select subscales may account for findings of age-related differences.

  14. Accuracy Validation of Large-scale Block Adjustment without Control of ZY3 Images over China

    NASA Astrophysics Data System (ADS)

    Yang, Bo

    2016-06-01

    Mapping from optical satellite images without ground control is one of the goals of photogrammetry. Using 8802 three linear array stereo images (a total of 26406 images) of ZY3 over China, we propose a large-scale and non-control block adjustment method of optical satellite images based on the RPC model, in which a single image is regarded as an adjustment unit to be organized. To overcome the block distortion caused by unstable adjustment without ground control and the excessive accumulation of errors, we use virtual control points created by the initial RPC model of the images as the weighted observations and add them into the adjustment model to refine the adjustment. We use 8000 uniformly distributed high precision check points to evaluate the geometric accuracy of the DOM (Digital Ortho Model) and DSM (Digital Surface Model) production, for which the standard deviations of plane and elevation are 3.6 m and 4.2 m respectively. The geometric accuracy is consistent across the whole block and the mosaic accuracy of neighboring DOM is within a pixel, thus, the seamless mosaic could take place. This method achieves the goal of an accuracy of mapping without ground control better than 5 m for the whole China from ZY3 satellite images.

  15. Validation of the Narrative Emplotment Scale and its correlations with well-being and psychological adjustment.

    PubMed

    Hill, Eric D; Terrell, Heather K; Hladkyj, Steven; Nagoshi, Craig T

    2009-11-01

    Two studies examined correlates of the Narrative Emplotment Scale (NES), which measures the extent to which individuals perceive chance events and unchosen experiences as meaningfully connected. In Study 1 (N=99), the NES demonstrated adequate test-retest stability and good internal reliability. The scale was positively related to paranormal beliefs, mystical experiences, and absorption. In Study 2 (N=342), personality measures indicative of external locus of control, intrinsic religiosity, well-being, satisfaction with life, and a measure of frequency of coincidence experience were all positively correlated with narrative emplotment, providing further support for the construct validity of the scale. In terms of the question of whether meaning making is predictive of better or worse psychological adjustment, analyses indicated that the relationship between narrative emplotment and psychological adjustment was moderated by individual differences in coping strategies. Path analysis indicated that emplotment was a mediator of the pathway between religiosity and well-being. Emplotment had a negative effect on well-being through chance locus of control. These analyses suggest that this type of meaning-making is an important variable for understanding religious/spiritual beliefs and their influence on psychological adjustment.

  16. EVALUATION OF A NEW MEAN SCALED AND MOMENT ADJUSTED TEST STATISTIC FOR SEM.

    PubMed

    Tong, Xiaoxiao; Bentler, Peter M

    2013-01-01

    Recently a new mean scaled and skewness adjusted test statistic was developed for evaluating structural equation models in small samples and with potentially nonnormal data, but this statistic has received only limited evaluation. The performance of this statistic is compared to normal theory maximum likelihood and two well-known robust test statistics. A modification to the Satorra-Bentler scaled statistic is developed for the condition that sample size is smaller than degrees of freedom. The behavior of the four test statistics is evaluated with a Monte Carlo confirmatory factor analysis study that varies seven sample sizes and three distributional conditions obtained using Headrick's fifth-order transformation to nonnormality. The new statistic performs badly in most conditions except under the normal distribution. The goodness-of-fit χ(2) test based on maximum-likelihood estimation performed well under normal distributions as well as under a condition of asymptotic robustness. The Satorra-Bentler scaled test statistic performed best overall, while the mean scaled and variance adjusted test statistic outperformed the others at small and moderate sample sizes under certain distributional conditions.

  17. Retaining Large and Adjustable Elastic Strains of Kilogram-Scale Nb Nanowires

    SciTech Connect

    Hao, Shijie; Cui, Lishan; Wang, Hua; Jiang, Daqiang; Liu, Yinong; Yan, Jiaqiang; Ren, Yang; Han, Xiaodong; Brown, Dennis E.; Li, Ju

    2016-02-10

    Individual metallic nanowires can sustain ultra-large elastic strains of 4-7%. However, achieving and retaining elastic strains of such magnitude in kilogram-scale nanowires are challenging. Here, we find that under active load, ~5.6% elastic strain can be achieved in Nb nanowires embedded in a metallic matrix deforming by detwinning. Moreover, large tensile (2.8%) and compressive (-2.4%) elastic strains can be retained in kilogram-scale Nb nanowires when the external load was fully removed, and adjustable in magnitude by processing control. It is then demonstrated that the retained tensile elastic strains of Nb nanowires can increase their superconducting transition temperature and critical magnetic field, in comparison with the unstrained original material. This study opens new avenues for retaining large and tunable elastic strains in great quantities of nanowires and elastic-strain-engineering at industrial scale.

  18. Coarse-scaling adjustment of fine-group neutron spectra for epithermal neutron beams in BNCT using multiple activation detectors

    NASA Astrophysics Data System (ADS)

    Liu, Yuan-Hao; Nievaart, Sander; Tsai, Pi-En; Liu, Hong-Ming; Moss, Ray; Jiang, Shiang-Huei

    2009-01-01

    In order to provide an improved and reliable neutron source description for treatment planning in boron neutron capture therapy (BNCT), a spectrum adjustment procedure named coarse-scaling adjustment has been developed and applied to the neutron spectrum measurements of both the Tsing Hua Open-pool Reactor (THOR) epithermal neutron beam in Taiwan and the High Flux Reactor (HFR) in The Netherlands, using multiple activation detectors. The coarse-scaling adjustment utilizes a similar idea as the well-known two-foil method, which adjusts the thermal and epithermal neutron fluxes according to the Maxwellian distribution for thermal neutrons and 1/ E distribution over the epithermal neutron energy region. The coarse-scaling adjustment can effectively suppress the number of oscillations appearing in the adjusted spectrum and provide better smoothness. This paper also presents a sophisticated 9-step process utilizing twice the coarse-scaling adjustment which can adjust a given coarse-group spectrum into a fine-group structure, i.e. 640 groups, with satisfactory continuity and excellently matched reaction rates between measurements and calculation. The spectrum adjustment algorithm applied in this study is the same as the well-known SAND-II.

  19. JPCam: Status of the 1.2Gpixel camera for the J-PAS survey.

    NASA Astrophysics Data System (ADS)

    Taylor, Keith; Marín-Franch, Antonio; Santoro, Fernando; Mendes de Oliveira, Claudia; Dupke, Renato

    2015-08-01

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k, 10 micron pixel detectors, to be deployed on the JST/T250, a dedicated 2.55m wide-field telescope at the OAJ (Observatorio Astrofísico de Javalambre) in Teruel, Spain. The camera is designed to perform the J-PAS, a BAO survey of the northern sky. The J-PAS survey strategy will use 59 filters, 56 relatively narrow-band (14.5nm) filters equi-spaced between 350 and 1000nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over 8000 square degrees of sky. The cryostat, detector mosaic and read electronics is being supplied by e2v. Each science detector is read from 16 ports simultaneously, allowing read times of 14s with a typical read noise of 5e- (rms). The JPCam focal plane will be complemented with 4 autoguiding and 8 wavefront sensing CCDs. Image quality over the whole CCD mosaic will be maintained by applying the required, close loop, focus, tilt and rotation adjustments to the focal plane through the JPCam hexapod actuator system, manufactured by NTE-Sener. The filter unit has been designed to admit 5 filter trays, each mounting 14 filters corresponding to the 14 CCDs of the mosaic. Each CCD will view only its corresponding filter avoiding optical cross-talk from their neighbors. With this configuration, JPCam will cover 4.7 square degrees with a plate scale of 0.2267 arcsec/pix and will allow all the J-PAS filters to be permanently installed on the camera. The massive 525mm aperture shutter is supplied by Bonn-Shutter UG.

  20. Effect of Adjusting Pseudo-Guessing Parameter Estimates on Test Scaling When Item Parameter Drift Is Present

    ERIC Educational Resources Information Center

    Han, Kyung T.; Wells, Craig S.; Hambleton, Ronald K.

    2015-01-01

    In item response theory test scaling/equating with the three-parameter model, the scaling coefficients A and B have no impact on the c-parameter estimates of the test items since the cparameter estimates are not adjusted in the scaling/equating procedure. The main research question in this study concerned how serious the consequences would be if…

  1. A scale on beliefs about children's adjustment in same-sex families: reliability and validity.

    PubMed

    Frias-Navarro, Dolores; Monterde-I-Bort, Hector

    2012-01-01

    In this study, we developed a new instrument named Scale Beliefs about Children's Adjustment on Same-Sex Families (SBCASSF). The scale was developed to assess of the adults' beliefs about negative impacts on children who are raised by same-sex parents. An initial pool of 95 items was generated by the authors based on a review of the literature on homophobia and feedback from several focus groups. Research findings, based on a sample of 212 university students (mean age 22 years, SD = 8.28), supported the reliability and validity of the scale. The final versions of the SBCASSF included items reflecting the following two factors: individual opposition (α = .87) and normative opposition (α = .88). Convergent validity of the scale is demonstrated by predictable correlations with beliefs about the cause of same-sex sexual orientation and the support for gay and lesbian rights. Our study reveals a strong positive association between high scores on SBCASSF and beliefs that the origin of same-sex sexual orientation is learned and opposition to gay and lesbian rights.

  2. CARINA data synthesis project: pH data scale unification and cruise adjustments

    NASA Astrophysics Data System (ADS)

    Velo, A.; Pérez, F. F.; Lin, X.; Key, R. M.; Tanhua, T.; de La Paz, M.; Olsen, A.; van Heuven, S.; Jutterström, S.; Ríos, A. F.

    2010-05-01

    Data on carbon and carbon-relevant hydrographic and hydrochemical parameters from 188 previously non-publicly available cruise data sets in the Artic Mediterranean Seas (AMS), Atlantic Ocean and Southern Ocean have been retrieved and merged to a new database: CARINA (CARbon IN the Atlantic Ocean). These data have gone through rigorous quality control (QC) procedures to assure the highest possible quality and consistency. The data for most of the measured parameters in the CARINA database were objectively examined in order to quantify systematic differences in the reported values. Systematic biases found in the data have been corrected in the data products, three merged data files with measured, calculated and interpolated data for each of the three CARINA regions; AMS, Atlantic Ocean and Southern Ocean. Out of a total of 188 cruise entries in the CARINA database, 59 reported pH measured values. All reported pH data have been unified to the Sea-Water Scale (SWS) at 25 °C. Here we present details of the secondary QC of pH in the CARINA database and the scale unification to SWS at 25 °C. The pH scale has been converted for 36 cruises. Procedures of quality control, including crossover analysis between cruises and inversion analysis are described. Adjustments were applied to the pH values for 21 of the cruises in the CARINA dataset. With these adjustments the CARINA database is consistent both internally as well as with the GLODAP data, an oceanographic data set based on the World Hydrographic Program in the 1990s. Based on our analysis we estimate the internal consistency of the CARINA pH data to be 0.005 pH units. The CARINA data are now suitable for accurate assessments of, for example, oceanic carbon inventories and uptake rates, for ocean acidification assessment and for model validation.

  3. Reach-Scale Channel Adjustments to Channel Network Geometry in Mountain Bedrock Streams

    NASA Astrophysics Data System (ADS)

    Plitzuweit, S. J.; Springer, G. S.

    2008-12-01

    Channel network geometry (CNG) is a critical determinant of hydrological response and may significantly affect incision processes within the Appalachian Plateau near Richwood, West Virginia. The Williams, Cherry, and Cranberry Rivers share drainage divides and their lower reaches flow atop resistant, quartz-rich sandstones. The lower two-thirds of the Cranberry and Williams Rivers display linear profiles atop the sandstones; whereas the Cherry is concave upwards atop the sandstones. Because lithologies and geological structures are similar among the watersheds, we tested whether differences in CNGs explain the profile shapes and reach-scale channel properties. Specifically, we quantified CNG by calculating reach- specific area-distance functions using DEMs. The area-distance functions were then converted into synthetic hydrographs to model hydrological responses. The Cherry River exhibits a classic dendritic drainage pattern, producing peaked hydrographs and low interval transit times. The Cranberry River displays a trellis-like drainage pattern, which produces attenuated hydrographs and high interval transit times. The upstream reaches of the Williams River have a dendritic drainage pattern, but the lower two-thirds of the watershed transitions into an elongated basin with trellis-like CNG. Reach gradients are steeper in the lower reaches of the Williams and Cranberry Rivers where hydrographs are attenuated. In contrast, peaked hydrographs within the Cherry River are associated with lower reach gradients despite resistant sandstone channel beds. Trellis-like CNG may restrict the ability of downstream reaches within the Williams and Cranberry Rivers to achieve the critical discharge needed to cause incision during floods (all other things being equal). If so, increased reach gradients may be hydraulic adjustments that compensate for comparatively low discharges. We are now applying the synthetic hydrographs to HEC-RAS flow models generated from field channel

  4. Does movement planning follow Fitts' law? Scaling anticipatory postural adjustments with movement speed and accuracy.

    PubMed

    Bertucco, M; Cesari, P

    2010-11-24

    We wanted to determine whether movement planning followed Fitts' law by investigating the relationship between movement planning and movement performance in experienced dancers executing a typical classical ballet step in which the big toe was pointed to targets at different distances and of different widths so as to obtain several indices of difficulty (ID). Movement time, velocity and variability at the target were the variables of movement performance kinematics; movement planning was evaluated by analysis of anticipatory postural adjustments (APAs) to assess their modulation at different IDs. Movement time and peak of velocity were found to scale with the ID only when individual movement distance across target widths was entered into the analysis. APA magnitude and duration both scaled according to movement parameters but not in the same way. APA magnitude scaled with movement velocity, while APA duration was sensitive to the amplitude-to-accuracy ratio following the ID for movements performed in the shortest time interval when on-line feedback control is probably not available. Here we show that timing of muscle activation acts as an independent central command that triggers fine-tuning for speed-accuracy trade-off.

  5. Reliability and validity of the work and social adjustment scale in phobic disorders.

    PubMed

    Mataix-Cols, David; Cowley, Amy J; Hankins, Matthew; Schneider, Andreas; Bachofen, Martin; Kenwright, Mark; Gega, Lina; Cameron, Rachel; Marks, Isaac M

    2005-01-01

    The Work and Social Adjustment Scale (WSAS) is a simple widely used 5-item measure of disability whose psychometric properties need more analysis in phobic disorders. The reliability, factor structure, validity, and sensitivity to change of the WSAS were studied in 205 phobic patients (73 agoraphobia, 62 social phobia, and 70 specific phobia) who participated in various open and randomized trials of self-exposure therapy. Internal consistency of the WSAS was excellent in all phobics pooled and in agoraphobics and social phobics separately. Principal components analysis extracted a single general factor of disability. Specific phobics gave less consistent ratings across WSAS items, suggesting that some items were less relevant to their problem. Internal consistency was marginally higher for self-ratings than clinician ratings of the WSAS. Self-ratings and clinician ratings correlated highly though patients tended to rate themselves as more disabled than clinicians did. WSAS total scores reflected differences in phobic severity and improvement with treatment. The WSAS is a valid, reliable, and change-sensitive measure of work/social and other adjustment in phobic disorders, especially in agoraphobia and social phobia.

  6. Evaluation of Logjam Scour in the Context of Reach-scale River Channel Adjustments

    NASA Astrophysics Data System (ADS)

    Hanrahan, T. P.; Vernon, C. R.

    2012-12-01

    River channel modifications for protection, enhancement and restoration often include flow resistance elements such as large wood and rock structures. Evaluating the effectiveness of these modifications in achieving design objectives can be confounded by river channel adjustments occurring at larger spatial scales throughout the reach of interest. Engineered logjams are one example where the design objectives typically include riverbed scour and the creation of pools. We surveyed riverbed elevations before and after the installation of engineered logjams, and compared those measurements to predictions from empirical scour equations. Riverbed elevations throughout the reach were also surveyed along cross-sections before and after restoration activities. River channel expansion and contraction throughout the reach was measured by mapping the unvegetated channel boundary for a period of years before and after restoration. Maximum riverbed scour immediately adjacent to the engineered logjams was 1.27 m, while maximum riverbed aggradation was 1.88 m. General riverbed scour and aggradation throughout the study reached was much larger, ranging from 2.71 m of scour to 2.96 m of aggradation. Over a period of 4 years, the channel expanded throughout the area of logjam installation, with increases in channel width ranging from 25.2 m to 58.2 m. Results from this study highlight the importance of considering large scale interactions between vegetation and river morphodynamics in the planning and implementation of river channel modifications.

  7. The British Sign Language Versions of the Patient Health Questionnaire, the Generalized Anxiety Disorder 7-Item Scale, and the Work and Social Adjustment Scale

    ERIC Educational Resources Information Center

    Rogers, Katherine D.; Young, Alys; Lovell, Karina; Campbell, Malcolm; Scott, Paul R.; Kendal, Sarah

    2013-01-01

    The present study is aimed to translate 3 widely used clinical assessment measures into British Sign Language (BSL), to pilot the BSL versions, and to establish their validity and reliability. These were the Patient Health Questionnaire (PHQ-9), the Generalized Anxiety Disorder 7-item (GAD-7) scale, and the Work and Social Adjustment Scale (WSAS).…

  8. Flexible sampling large-scale social networks by self-adjustable random walk

    NASA Astrophysics Data System (ADS)

    Xu, Xiao-Ke; Zhu, Jonathan J. H.

    2016-12-01

    Online social networks (OSNs) have become an increasingly attractive gold mine for academic and commercial researchers. However, research on OSNs faces a number of difficult challenges. One bottleneck lies in the massive quantity and often unavailability of OSN population data. Sampling perhaps becomes the only feasible solution to the problems. How to draw samples that can represent the underlying OSNs has remained a formidable task because of a number of conceptual and methodological reasons. Especially, most of the empirically-driven studies on network sampling are confined to simulated data or sub-graph data, which are fundamentally different from real and complete-graph OSNs. In the current study, we propose a flexible sampling method, called Self-Adjustable Random Walk (SARW), and test it against with the population data of a real large-scale OSN. We evaluate the strengths of the sampling method in comparison with four prevailing methods, including uniform, breadth-first search (BFS), random walk (RW), and revised RW (i.e., MHRW) sampling. We try to mix both induced-edge and external-edge information of sampled nodes together in the same sampling process. Our results show that the SARW sampling method has been able to generate unbiased samples of OSNs with maximal precision and minimal cost. The study is helpful for the practice of OSN research by providing a highly needed sampling tools, for the methodological development of large-scale network sampling by comparative evaluations of existing sampling methods, and for the theoretical understanding of human networks by highlighting discrepancies and contradictions between existing knowledge/assumptions of large-scale real OSN data.

  9. Development and Validation of a Brief Version of the Dyadic Adjustment Scale With a Nonparametric Item Analysis Model

    ERIC Educational Resources Information Center

    Sabourin, Stephane; Valois, Pierre; Lussier, Yvan

    2005-01-01

    The main purpose of the current research was to develop an abbreviated form of the Dyadic Adjustment Scale (DAS) with nonparametric item response theory. The authors conducted 5 studies, with a total participation of 8,256 married or cohabiting individuals. Results showed that the item characteristic curves behaved in a monotonically increasing…

  10. Assessing Changes in Socioemotional Adjustment across Early School Transitions--New National Scales for Children at Risk

    ERIC Educational Resources Information Center

    McDermott, Paul A.; Watkins, Marley W.; Rovine, Michael J.; Rikoon, Samuel H.

    2013-01-01

    This article reports the development and evidence for validity and application of the Adjustment Scales for Early Transition in Schooling (ASETS). Based on primary analyses of data from the Head Start Impact Study, a nationally representative sample (N = 3077) of randomly selected children from low-income households is configured to inform…

  11. Fracture-based Fabrication of Normally-closed, Adjustable and Fully Reversible Micro-scale Fluidic Channels

    PubMed Central

    Huang, Jiexi; Matsuoka, Toshiki; Thouless, M.D.; Takayama, Shuichi

    2014-01-01

    Adjustable fluidic structures play an important role in microfluidic systems. Fracture of multilayered materials under applied tension has been previously demonstrated as a convenient, simple and inexpensive approach to fabricate nano-scale adjustable structures; here, we demonstrate how to extend this concept to the micro-scale. We achieve this by a novel pairing of materials that leverages fracture mechanics to limit crack formation to a specified region, allowing us to create size-controllable and adjustable microfluidic structures. We demonstrate that this technique can be used to fabricate ‘normally-closed’ microfluidic channels that are completely reversible, a feature that is challenging to achieve in conventional systems without careful engineering controls. The adjustable microfluidic channels are then applied to mechanically lyse single cells, and subsequently manipulate the released nuclear chromatin, creating new possibilities for epigenetic analysis of single cells. This simple, versatile and robust technology provides an easily accessible pathway to construct adjustable microfluidic structures, which will be useful in developing complex assays and experiments even in resource-limited settings. PMID:24942855

  12. Dialysis Dose Scaled to Body Surface Area and Size-Adjusted, Sex-Specific Patient Mortality

    PubMed Central

    Kapke, Alissa; Port, Friedrich K.; Wolfe, Robert A.; Saran, Rajiv; Pearson, Jeffrey; Hirth, Richard A.; Messana, Joseph M.; Daugirdas, John T.

    2012-01-01

    Summary Background and objectives When hemodialysis dose is scaled to body water (V), women typically receive a greater dose than men, but their survival is not better given a similar dose. This study sought to determine whether rescaling dose to body surface area (SA) might reveal different associations among dose, sex, and mortality. Design, setting, participants, & measurements Single-pool Kt/V (spKt/V), equilibrated Kt/V, and standard Kt/V (stdKt/V) were computed using urea kinetic modeling on a prevalent cohort of 7229 patients undergoing thrice-weekly hemodialysis. Data were obtained from the Centers for Medicare & Medicaid Services 2008 ESRD Clinical Performance Measures Project. SA-normalized stdKt/V (SAN-stdKt/V) was calculated as stdKt/V × ratio of anthropometric volume to SA/17.5. Patients were grouped into sex-specific dose quintiles (reference: quintile 1 for men). Adjusted hazard ratios (HRs) for 1-year mortality were calculated using Cox regression. Results spKt/V was higher in women (1.7±0.3) than in men (1.5±0.2; P<0.001), but SAN-stdKt/V was lower (women: 2.3±0.2; men: 2.5±0.3; P<0.001). For both sexes, mortality decreased as spKt/V increased, until spKt/V was 1.6–1.7 (quintile 4 for men: HR, 0.62; quintile 3 for women: HR, 0.64); no benefit was observed with higher spKt/V. HR for mortality decreased further at higher SAN-stdKt/V in both sexes (quintile 5 for men: HR, 0.69; quintile 5 for women: HR, 0.60). Conclusions SA-based dialysis dose results in dose-mortality relationships substantially different from those with volume-based dosing. SAN-stdKt/V analyses suggest women may be relatively underdosed when treated by V-based dosing. SAN-stdKt/V as a measure for dialysis dose may warrant further study. PMID:22977208

  13. Least squares adjustment of large-scale geodetic networks by orthogonal decomposition

    SciTech Connect

    George, J.A.; Golub, G.H.; Heath, M.T.; Plemmons, R.J.

    1981-11-01

    This article reviews some recent developments in the solution of large sparse least squares problems typical of those arising in geodetic adjustment problems. The new methods are distinguished by their use of orthogonal transformations which tend to improve numerical accuracy over the conventional approach based on the use of the normal equations. The adaptation of these new schemes to allow for the use of auxiliary storage and their extension to rank deficient problems are also described.

  14. Scale-Adjusted Metrics for Predicting the Evolution of Urban Indicators and Quantifying the Performance of Cities.

    PubMed

    Alves, Luiz G A; Mendes, Renio S; Lenzi, Ervin K; Ribeiro, Haroldo V

    2015-01-01

    More than a half of world population is now living in cities and this number is expected to be two-thirds by 2050. Fostered by the relevancy of a scientific characterization of cities and for the availability of an unprecedented amount of data, academics have recently immersed in this topic and one of the most striking and universal finding was the discovery of robust allometric scaling laws between several urban indicators and the population size. Despite that, most governmental reports and several academic works still ignore these nonlinearities by often analyzing the raw or the per capita value of urban indicators, a practice that actually makes the urban metrics biased towards small or large cities depending on whether we have super or sublinear allometries. By following the ideas of Bettencourt et al. [PLoS ONE 5 (2010) e13541], we account for this bias by evaluating the difference between the actual value of an urban indicator and the value expected by the allometry with the population size. We show that this scale-adjusted metric provides a more appropriate/informative summary of the evolution of urban indicators and reveals patterns that do not appear in the evolution of per capita values of indicators obtained from Brazilian cities. We also show that these scale-adjusted metrics are strongly correlated with their past values by a linear correspondence and that they also display crosscorrelations among themselves. Simple linear models account for 31%-97% of the observed variance in data and correctly reproduce the average of the scale-adjusted metric when grouping the cities in above and below the allometric laws. We further employ these models to forecast future values of urban indicators and, by visualizing the predicted changes, we verify the emergence of spatial clusters characterized by regions of the Brazilian territory where we expect an increase or a decrease in the values of urban indicators.

  15. Scale-Adjusted Metrics for Predicting the Evolution of Urban Indicators and Quantifying the Performance of Cities

    PubMed Central

    Alves, Luiz G. A.; Mendes, Renio S.; Lenzi, Ervin K.; Ribeiro, Haroldo V.

    2015-01-01

    More than a half of world population is now living in cities and this number is expected to be two-thirds by 2050. Fostered by the relevancy of a scientific characterization of cities and for the availability of an unprecedented amount of data, academics have recently immersed in this topic and one of the most striking and universal finding was the discovery of robust allometric scaling laws between several urban indicators and the population size. Despite that, most governmental reports and several academic works still ignore these nonlinearities by often analyzing the raw or the per capita value of urban indicators, a practice that actually makes the urban metrics biased towards small or large cities depending on whether we have super or sublinear allometries. By following the ideas of Bettencourt et al. [PLoS ONE 5 (2010) e13541], we account for this bias by evaluating the difference between the actual value of an urban indicator and the value expected by the allometry with the population size. We show that this scale-adjusted metric provides a more appropriate/informative summary of the evolution of urban indicators and reveals patterns that do not appear in the evolution of per capita values of indicators obtained from Brazilian cities. We also show that these scale-adjusted metrics are strongly correlated with their past values by a linear correspondence and that they also display crosscorrelations among themselves. Simple linear models account for 31%–97% of the observed variance in data and correctly reproduce the average of the scale-adjusted metric when grouping the cities in above and below the allometric laws. We further employ these models to forecast future values of urban indicators and, by visualizing the predicted changes, we verify the emergence of spatial clusters characterized by regions of the Brazilian territory where we expect an increase or a decrease in the values of urban indicators. PMID:26356081

  16. The evolution of PAs in the Canadian Armed Forces.

    PubMed

    Mertens, Jonathan; Descoteaux, Marc

    2017-01-01

    This study documents the growing role of the physician assistant (PA) in the Canadian Armed Forces. PAs have served as the backbone of the Royal Canadian Medical Services' frontline medical operations since 1984, on land, aboard ships and submarines, and domestically in garrison. Candidates begin as medical technicians and receive advanced training to become PAs at midcareer. The current rank of PAs as warrant officers is evolving and a commissioned status is under consideration.

  17. PAS kinase: a nutrient sensing regulator of glucose homeostasis.

    PubMed

    DeMille, Desiree; Grose, Julianne H

    2013-11-01

    Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose availability and regulates glucose homeostasis in yeast, mice, and man. Despite this pivotal role, the molecular mechanisms of PAS kinase regulation and function are largely unknown. This review focuses on what is known about PAS kinase, including its conservation from yeast to man, identified substrates, associated phenotypes and role in metabolic disease.

  18. Within-Semester Stability and Adjustment Correlates of the Multidimensional Perfectionism Scale.

    ERIC Educational Resources Information Center

    Rice, Kenneth G.; Dellwo, Jacqueline P.

    2001-01-01

    Subscale scores from R.O. Frost, P. Marten, C. Lahart, and R. Rosenblate's (1990) Mulitdimensional Perfectionism Scale were found to be moderately stable over a 10-week period. Associations between perfectionism and self-esteem, depression, and academic integration yielded mixed support for the criterion-related validity of the scores from this…

  19. Testing the Short and Screener versions of the Social Adjustment Scale-Self-report (SAS-SR).

    PubMed

    Gameroff, Marc J; Wickramaratne, Priya; Weissman, Myrna M

    2012-03-01

    The 54-item Social Adjustment Scale-Self-report (SAS-SR) is a measure of social functioning used in research studies and clinical practice. Two shortened versions were recently developed: the 24-item SAS-SR: Short and the 14-item SAS-SR: Screener. We briefly describe the development of the shortened scales and then assess their reliability and validity in comparison to the full SAS-SR in new analyses from two separate samples of convenience from a family study and from a primary care clinic. Compared to the full SAS-SR, the shortened scales performed well, exhibiting high correlations with full SAS-SR scores (r values between 0.81 and 0.95); significant correlations with health-related quality of life as measured by the Short Form 36 Health Survey; the ability to distinguish subjects with major depression versus other psychiatric disorders versus no mental disorders; and sensitivity to change in clinical status as measured longitudinally with the Symptom Checklist-90 and Global Assessment Scale. The SAS-SR: Short and SAS-SR: Screener retained the areas assessed by the full SAS-SR with fewer items in each area, and appear to be promising replacements for the full scale when a shorter administration time is desired and detailed information on performance in different areas is not required. Further work is needed to test the validity of the shortened measures.

  20. Dose-Weighted Adjusted Mantel-Haenszel Tests for Numeric Scaled Strata in a Randomized Trial

    PubMed Central

    Gansky, Stuart A.; Cheng, Nancy F.; Koch, Gary G.

    2011-01-01

    A recent three-arm parallel groups randomized clinical prevention trial had a protocol deviation causing participants to have fewer active doses of an in-office treatment than planned. The original statistical analysis plan stipulated a minimal assumption randomization-based extended Mantel-Haenszel (EMH) trend test of the high frequency, low frequency, and zero frequency treatment groups and a binary outcome. Thus a dose-weighted adjusted EMH (DWAEMH) test was developed with an extra set of weights corresponding to the number of active doses actually available, in the spirit of a pattern mixture model. The method can easily be implemented using standard statistical software. A set of Monte Carlo simulations using a logistic model was undertaken with (and without) actual dose-response effects through 1000 replicates for empirical power estimates (and 2100 for empirical size). Results showed size was maintained and power was improved for DWAEMH versus EMH and logistic regression Wald tests in the presence of a dose effect and treatment by dose interaction. PMID:21709814

  1. Millenial scale changes in flood magnitude and frequency and the role of changes in channel adjustment.

    NASA Astrophysics Data System (ADS)

    Croke, Jacky; Thompson, Christopher; Denham, Robert; Haines, Heather; Sharma, Ashneel; Pietsch, Timothy

    2016-04-01

    With access to only limited gauging records (~ 37 years in eastern Australia), Australia like many parts of the globe is heavily constrained in its ability to meaningfully predict the magnitude and frequency of extreme flood events. Flood inundation data gathered during recent floods (2011 and 213) now forms an essential insight into how landscapes may respond to future floods and to guide planning and policy. This study presents the first singe-catchment flood reconstruction analyses in a region of recognised hydrological variability, as characterised by alternating extremes of floods and droughts. The resultant 'Big Flood' data set consists of a unique combination of high-resolution topographic data on landscape changes during recent floods, and a detailed reconstruction of both the timing and estimated magnitude of past food events derived using OSL dating of flood deposits from a range of sedimentary environments. While distinct flood and drought 'phases' are recognisable over the timescale of several thousand years, the extent to which these reflect changes in flood magnitude and/or frequency remains complicated by catchment-specific geomorphology. Issues of flood sample preservation are discussed in this talk within the context of geomorphic setting and notably non-linear variations in the capacity for channel adjustment. This talk outlines the key factors which must be considered in evaluating the role of climate, landuse change and geomorphology in informing flood risk management in Queensland.

  2. British community pharmacists' views of physician-assisted suicide (PAS)

    PubMed Central

    Hanlon, T.; Weiss, M.; Rees, J.

    2000-01-01

    Objectives— To explore British community pharmacists' views on PAS , including professional responsibility, personal beliefs, changes in law and ethical guidance. Design— Postal questionnaire Setting— Great Britain Subjects— A random sample of 320 registered full-time community pharmacists Results— The survey yielded a response rate of 56%. The results showed that 70% of pharmacists agreed that it was a patient's right to choose to die, with 57% and 45% agreeing that it was the patient's right to involve his/her doctor in the process and to use prescription medicines, respectively. Forty-nine per cent said that they would knowingly dispense a prescription for use in PAS were it to be legalised and 54% believed it correct to refuse to dispense such a prescription. Although 53% believed it to be their right to know when they were being involved in PAS, 28% did not. Most pharmacists (90%) said that they would wish to see the inclusion of a practice protocol for PAS in the code of ethics of the Royal Pharmaceutical Society of Great Britain (CE-RPSGB) in the event of a change in the law on PAS. In addition, 89% would wish to see PAS included in the Conscience Clause of the CE-RPSGB. Males were found to be significantly less likely to favour PAS than females (p<0.05), as were those declaring an ethnic/religious background of consideration when dealing with ethical issues in practice compared with their counterparts (p<0.00005). Conclusion— Pharmacists view their professional responsibility in PAS to be more obligatory than a physician's, in having to provide the means for PAS. It is worrying that a proportion of the respondents prefer to remain in ignorance of the true purpose of a prescription for PAS; a finding at odds with current developments within the pharmaceutical profession. A practice protocol for PAS and an extension of the conscience clause should be considered in the event of PAS becoming legal. Such measures would allow the efficient provision

  3. Histopathological examination of nail clippings using PAS staining (HPE-PAS): gold standard in diagnosis of Onychomycosis.

    PubMed

    Jeelani, Shazia; Ahmed, Qazi Masood; Lanker, Audil Mohmad; Hassan, Iffat; Jeelani, Nasir; Fazili, Tawheeda

    2015-01-01

    Onychomycosis is fungal infection of one or more of the nail units. However, because fungi cause only about half of all nail dystrophies, the use of appropriate diagnostic techniques is important to ensure correct diagnosis and treatment. Aim of the present study was to compare direct microscopy, culture and HPE-PAS for diagnosis of onychomycosis by evaluating their sensitivity and various other relevant statistical parameters. A prospective, hospital-based, cross-sectional study was conducted on 216 patients with a high degree of clinical suspicion of onychomycosis. Nail specimens were evaluated using three diagnostic methods, i.e. direct microscopy using 20% Potassium hydroxide (KOH) & 40% Di-methyl-suphoxide (DMSO), culture and histopathological examination using PAS stain (HPE-PAS). Of 216 patients direct microscopy was positive in 138 (63.9%), culture in 147 (68%) and HPE-PAS in 164 patients (76%). One hundred and seventy-nine patients fitted into the criteria set for confirmed diagnosis of onychomycosis. Using this as a denominator; direct microscopy, culture and HPE-PAS had sensitivities of 77.1%, 70% and 91.6% respectively. Also, HPE-PAS showed the highest sensitivity of 94.7% in 19 cases with prediagnostic antimycotic treatment compared to direct microscopy (42.1%) or culture (57.9%). HPE-PAS shows high sensitivity for diagnosis of onychomycosis and can be considered as a gold standard in the diagnosis of onychomycosis.

  4. Parenting and Family Adjustment Scales (PAFAS): validation of a brief parent-report measure for use in assessment of parenting skills and family relationships.

    PubMed

    Sanders, Matthew R; Morawska, Alina; Haslam, Divna M; Filus, Ania; Fletcher, Renee

    2014-06-01

    This study examined the psychometric characteristics of the Parent and Family Adjustment Scales (PAFAS). The PAFAS was designed as a brief outcome measure for assessing changes in parenting practices and parental adjustment in the evaluation of both public health and individual or group parenting interventions. The inventory consists of the Parenting scale measuring parenting practices and quality of parent-child relationship and of the Family Adjustment scale measuring parental emotional adjustment and partner and family support in parenting. Two studies were conducted to validate the inventory. A sample of 370 parents participated in Study 1 and a sample of 771 parents participated in Study 2. Children's ages ranged from 2 to 12 years old. In Study 1 confirmatory factor analysis supported an 18-item, four factor model of PAFAS Parenting, and a 12-item, three factor model of PAFAS Family Adjustment. Psychometric evaluation of the PAFAS revealed that the scales had good internal consistency, as well as satisfactory construct and predictive validity. In Study 2 confirmatory factor analysis supported stability of the factor structures of PAFAS Parenting and PAFAS Family Adjustment revealed in Study 1. Potential uses of the measure and implications for future validation studies are discussed.

  5. Feasibility of classification of clay minerals by using PAS

    NASA Astrophysics Data System (ADS)

    Honda, Y.; Yoshida, Y.; Akiyama, Y.; Nishijima, S.

    2015-06-01

    After the nuclear power plant disaster, the evaluation of radioactive Cs kept in soil, especially in clay minerals and the elucidation of its movement are urgent subjects to promote decontamination. It is known that the extractable level of Cs depends on the sort of clay minerals. We tried to find the characteristics of clay minerals belonging to phillosilicate group using positron annihilation spectroscopy (PAS) and the relationship between the results of PAS and the amounts of substantially extracted Cs from the clay minerals. The results showed that each clay mineral was found to be distinguishable from other clay minerals by PAS and the extraction rate of Cs was different among those clay minerals, however the direct correlation between the results of PAS and the extraction rates of Cs was not found.

  6. The British Sign Language versions of the Patient Health Questionnaire, the Generalized Anxiety Disorder 7-item Scale, and the Work and Social Adjustment Scale.

    PubMed

    Rogers, Katherine D; Young, Alys; Lovell, Karina; Campbell, Malcolm; Scott, Paul R; Kendal, Sarah

    2013-01-01

    The present study is aimed to translate 3 widely used clinical assessment measures into British Sign Language (BSL), to pilot the BSL versions, and to establish their validity and reliability. These were the Patient Health Questionnaire (PHQ-9), the Generalized Anxiety Disorder 7-item (GAD-7) scale, and the Work and Social Adjustment Scale (WSAS). The 3 assessment measures were translated into BSL and piloted with the Deaf signing population in the United Kingdom (n = 113). Participants completed the PHQ-9, GAD-7, WSAS, and Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) online. The reliability and validity of the BSL versions of PHQ-9, GAD-7, and WSAS have been examined and were found to be good. The construct validity for the PHQ-9 BSL version did not find the single-factor solution as found in the hearing population. The BSL versions of PHQ-9, GAD-7, and WSAS have been produced in BSL and can be used with the signing Deaf population in the United Kingdom. This means that now there are accessible mental health assessments available for Deaf people who are BSL users, which could assist in the early identification of mental health difficulties.

  7. Structural properties of PAS domains from the KCNH potassium channels.

    PubMed

    Adaixo, Ricardo; Harley, Carol A; Castro-Rodrigues, Artur F; Morais-Cabral, João H

    2013-01-01

    KCNH channels form an important family of voltage gated potassium channels. These channels include a N-terminal Per-Arnt-Sim (PAS) domain with unknown function. In other proteins PAS domains are implicated in cellular responses to environmental queues through small molecule binding or involvement in signaling cascades. To better understand their role we characterized the structural properties of several channel PAS domains. We determined high resolution structures of PAS domains from the mouse EAG (mEAG), drosophila ELK (dELK) and human ERG (hERG) channels and also of the hERG domain without the first nine amino acids. We analyzed these structures for features connected to ligand binding and signaling in other PAS domains. In particular, we have found cavities in the hERG and mEAG structures that share similarities with the ligand binding sites from other PAS domains. These cavities are lined by polar and apolar chemical groups and display potential flexibility in their volume. We have also found that the hydrophobic patch on the domain β-sheet is a conserved feature and appears to drive the formation of protein-protein contacts. In addition, the structures of the dELK domain and of the truncated hERG domain revealed the presence of N-terminal helices. These helices are equivalent to the helix described in the hERG NMR structures and are known to be important for channel function. Overall, these channel domains retain many of the PAS domain characteristics known to be important for cell signaling.

  8. How Elephant Seals (Mirounga leonina) Adjust Their Fine Scale Horizontal Movement and Diving Behaviour in Relation to Prey Encounter Rate

    PubMed Central

    Jouma’a, Joffrey; Picard, Baptiste; Guinet, Christophe

    2016-01-01

    Understanding the diving behaviour of diving predators in relation to concomitant prey distribution could have major practical applications in conservation biology by allowing the assessment of how changes in fine scale prey distribution impact foraging efficiency and ultimately population dynamics. The southern elephant seal (Mirounga leonina, hereafter SES), the largest phocid, is a major predator of the southern ocean feeding on myctophids and cephalopods. Because of its large size it can carry bio-loggers with minimal disturbance. Moreover, it has great diving abilities and a wide foraging habitat. Thus, the SES is a well suited model species to study predator diving behaviour and the distribution of ecologically important prey species in the Southern Ocean. In this study, we examined how SESs adjust their diving behaviour and horizontal movements in response to fine scale prey encounter densities using high resolution accelerometers, magnetometers, pressure sensors and GPS loggers. When high prey encounter rates were encountered, animals responded by (1) diving and returning to the surface with steeper angles, reducing the duration of transit dive phases (thus improving dive efficiency), and (2) exhibiting more horizontally and vertically sinuous bottom phases. In these cases, the distance travelled horizontally at the surface was reduced. This behaviour is likely to counteract horizontal displacement from water currents, as they try to remain within favourable prey patches. The prey encounter rate at the bottom of dives decreased with increasing diving depth, suggesting a combined effect of decreased accessibility and prey density with increasing depth. Prey encounter rate also decreased when the bottom phases of dives were spread across larger vertical extents of the water column. This result suggests that the vertical aggregation of prey can regulate prey density, and as a consequence impact the foraging success of SESs. To our knowledge, this is one of

  9. The Brief Self-Control Scale Predicts Jail Inmates’ Recidivism, Substance Dependence, and Post-Release Adjustment

    PubMed Central

    2015-01-01

    Previous research finds that self-control is positively associated with adaptive and negatively associated with maladaptive behavior. However, most previous studies employ cross-sectional designs, low-risk samples, and limited assessments of self-control. This study of 553 jail inmates examined the relationship of a valid measure of self-control (Brief Self-Control Scale; BSCS) completed upon incarceration with behavior before, during, and one year after incarceration. After controlling for positive impression management (PIM), self-control was negatively related to substance misuse, suicidality, risky sex, and criminal history prior to incarceration and post-release illegal substance misuse, recidivism, and positive adjustment. Lower self-control predicted increases in substance dependence at post-release compared to pre-incarceration. Self-control was not related to misbehavior during incarceration, nor alcohol use or HIV-risk behavior one year post-release. Results were consistent as a function of age, race, and gender. This study supports self-control as an important risk and protective factor in a sample of criminal offenders. PMID:24345712

  10. Extravehicular Activity (EVA) Power, Avionics, and Software (PAS) 101

    NASA Technical Reports Server (NTRS)

    Irimies, David

    2011-01-01

    EVA systems consist of a spacesuit or garment, a PLSS, a PAS system, and spacesuit interface hardware. The PAS system is responsible for providing power for the suit, communication of several types of data between the suit and other mission assets, avionics hardware to perform numerous data display and processing functions, and information systems that provide crewmembers data to perform their tasks with more autonomy and efficiency. Irimies discussed how technology development efforts have advanced the state-of-the-art in these areas and shared technology development challenges.

  11. Marketing and medicine. A basic guide for PAs.

    PubMed

    Blessing, J D; Davis, N L

    1988-07-01

    Marketing is a conscious plan to influence the behavior of others. Physician assistants can use marketing techniques to promote themselves and their profession as well as to help build a practice and improve patient services. Basic components of a marketing strategy include analysis, planning, implementation, and monitoring. Marketing tools easily accessible to PAs are the telephone (call to check on compliance); a photocopy machine (patient handouts and practice newsletters); and the mail (postcard to remind of follow-up visit).

  12. Bundle block adjustment of large-scale remote sensing data with Block-based Sparse Matrix Compression combined with Preconditioned Conjugate Gradient

    NASA Astrophysics Data System (ADS)

    Zheng, Maoteng; Zhang, Yongjun; Zhou, Shunping; Zhu, Junfeng; Xiong, Xiaodong

    2016-07-01

    In recent years, new platforms and sensors in photogrammetry, remote sensing and computer vision areas have become available, such as Unmanned Aircraft Vehicles (UAV), oblique camera systems, common digital cameras and even mobile phone cameras. Images collected by all these kinds of sensors could be used as remote sensing data sources. These sensors can obtain large-scale remote sensing data which consist of a great number of images. Bundle block adjustment of large-scale data with conventional algorithm is very time and space (memory) consuming due to the super large normal matrix arising from large-scale data. In this paper, an efficient Block-based Sparse Matrix Compression (BSMC) method combined with the Preconditioned Conjugate Gradient (PCG) algorithm is chosen to develop a stable and efficient bundle block adjustment system in order to deal with the large-scale remote sensing data. The main contribution of this work is the BSMC-based PCG algorithm which is more efficient in time and memory than the traditional algorithm without compromising the accuracy. Totally 8 datasets of real data are used to test our proposed method. Preliminary results have shown that the BSMC method can efficiently decrease the time and memory requirement of large-scale data.

  13. A biogenic CO2 flux adjustment scheme for the mitigation of large-scale biases in global atmospheric CO2 analyses and forecasts

    NASA Astrophysics Data System (ADS)

    Agustí-Panareda, Anna; Massart, Sébastien; Chevallier, Frédéric; Balsamo, Gianpaolo; Boussetta, Souhail; Dutra, Emanuel; Beljaars, Anton

    2016-08-01

    Forecasting atmospheric CO2 daily at the global scale with a good accuracy like it is done for the weather is a challenging task. However, it is also one of the key areas of development to bridge the gaps between weather, air quality and climate models. The challenge stems from the fact that atmospheric CO2 is largely controlled by the CO2 fluxes at the surface, which are difficult to constrain with observations. In particular, the biogenic fluxes simulated by land surface models show skill in detecting synoptic and regional-scale disturbances up to sub-seasonal time-scales, but they are subject to large seasonal and annual budget errors at global scale, usually requiring a posteriori adjustment. This paper presents a scheme to diagnose and mitigate model errors associated with biogenic fluxes within an atmospheric CO2 forecasting system. The scheme is an adaptive scaling procedure referred to as a biogenic flux adjustment scheme (BFAS), and it can be applied automatically in real time throughout the forecast. The BFAS method generally improves the continental budget of CO2 fluxes in the model by combining information from three sources: (1) retrospective fluxes estimated by a global flux inversion system, (2) land-use information, (3) simulated fluxes from the model. The method is shown to produce enhanced skill in the daily CO2 10-day forecasts without requiring continuous manual intervention. Therefore, it is particularly suitable for near-real-time CO2 analysis and forecasting systems.

  14. Effects of Systematic Group Counseling on Work Adjustment Clients

    ERIC Educational Resources Information Center

    Roessler, Richard; And Others

    1977-01-01

    When compared with a group of clients who had received work adjustment services and a placebo treatment (personal hygiene training), experimental clients given Personal Achievement Skills (PAS) and work adjustment services reported greater gains on self-ratings of life perspective (optimism), work-related attitudes, and goal attainment. (Author)

  15. Geodynamic Research at the Department of Planetary Geodesy, SRC PAS

    NASA Astrophysics Data System (ADS)

    Brzeziński, Aleksander; Jóźwik, Mieczysław; Kaczorowski, Marek; Kalarus, Maciej; Kasza, Damian; Kosek, Wiesław; Nastula, Jolanta; Szczerbowski, Zbigniew; Wińska, Małgorzata; Wronowski, Roman; Zdunek, Ryszard; Zieliński, Janusz B.

    2016-06-01

    The Department of Planetary Geodesy of the Space Research Centre PAS has been conducting research on a broad spectrum of problems within a field of global dynamics of the Earth. In this report we describe the investigations on selected subjects concerning polar motion (modeling and geophysical interpretation of the Chandler wobble, hydrological excitation of seasonal signals, search for optimal prediction methods), tectonic activity in the region of the Książ Geodynamic Laboratory of the SRC, and finally the new joint Polish-Italian project GalAc analyzing feasibility and usefulness of equipping second-generation Galileo satellites with accelerometers.

  16. JPCam: Development of a 1.2 Gpixel Camera for the J-PAS Survey

    NASA Astrophysics Data System (ADS)

    Marín-Franch, A.; Taylor, K.; Santoro, F. G.; Laporte, R.; Cepa, J.; Lasso-Cabrera, N.; Yanes-Díaz, A.; Cenarro, A. J.; Cristobal-Hornillos, D.; Ederoclite, A.; Moles, M.; Varela, J.; Vázquez-Ramió, H.; Antón, J. L.; Bello, R.; Civera, T.; Castillo, J.,; Chueca, S.; Guillén-Civera, L.; Hernández-Fuertes, J.; Igual, R.; Íniguez, C.; López-Alegre, G.; López-Sainz, A.; Nevot, C.; Milla, R.; Muniesa, D.; Pe, A.; Rueda-Teruel, R.; Rueda-Teruel, F.; Sánchez, J.; Benitez, N.; Dupke, R.; Fernández-Soto, A.; Mendes de Oliveira, C.; Sodré, L.

    2017-03-01

    To carry out J-PAS survey, the JST/T250 telescope at the Observatorio Astrofósico de Javalambre (OAJ) is equipped with JPCam, a panoramic camera designed to exploit survey capabilities of the telescope. JPCam is a direct imaging instrument designed to work in a fast convergent beam at the telescope’s Cassegrain focus. It is based on state-of-the-art, high efficiency, low noise 9.2k-by-9.2k, 10μm pixel CCDs specially developed by e2v for JPCam. The instrument is equipped with a 1.2Gpixel mosaic of 14 CCDs providing a useful FoV of 4.7 deg2 (67% focal plane coverage) with a plate scale of 0.2267 arcsec/pix. Moreover, JPCam includes 12 auxiliary detectors for auto-guiding and wave front sensing purposes. JPCam is completed with an innovative set of 59 optical filters specifically designed to perform accurate BAO measurements, main science driver of J-PAS.

  17. Comparison of two different passive air samplers (PUF-PAS versus SIP-PAS) to determine time-integrated average air concentration of volatile hydrophobic organic pollutants

    NASA Astrophysics Data System (ADS)

    Kim, Seung-Kyu; Park, Jong-Eun

    2014-06-01

    Despite remarkable achievements with r some chemicals, a field-measurement technique has not been advanced for volatile hydrophobic organic chemicals (HOCs) that are the subjects of international concern. This study assesses the applicability of passive air sampling (PAS) by comparing PUF-PAS and its modified SIP-PAS which was made by impregnating XAD-4 powder into PUF, overviewing the principles of PAS, screening sensitive parameters, and determining the uncertainty range of PAS-derived concentration. The PAS air sampling rate determined in this study, corrected by a co-deployed low-volume active air sampler (LAS) for neutral PFCs as model chemicals, was ˜1.2 m3 day-1. Our assessment shows that the improved sorption capacity in a SIP lengthens PAS deployment duration by expanding the linear uptake range and then enlarges the effective air sampling volume and detection frequency of chemicals at trace level. Consequently, volatile chemicals can be collected during sufficiently long times without reaching equilibrium when using SIP, while this is not possible for PUF. The most sensitive parameter to influence PAS-derived CA was an air-side mass transfer coefficient (kA), implying the necessity of spiking depuration chemicals (DCs) because this parameter is strongly related with meteorological conditions. Uncertainty in partition coefficients (KPSM-A or KOA) influences PAS-derived CA to a greater extent with regard to lower KPSM-A chemicals. Also, the PAS-derived CA has an uncertainty range of a half level to a 3-fold higher level of the calculated one. This work is expected to establish solid grounds for the improvement of field measurement technique of HOCs.

  18. Detecting Defects in Aircraft Materials by Nuclear Technique (pas)

    NASA Astrophysics Data System (ADS)

    Badawi, Emad. A.

    Positron annihilation spectroscopy (PAS) is one of the nuclear techniques used in material science. The present measurements are used to study the behavior of defect concentration in one of the most important materials aluminum alloys which is the 7075 alloy. It has been shown that positrons can become trapped at imperfect locations in solids and their mean lifetime can be influenced by changes in the concentration of such defects. No changes have been observed in the mean lifetime values after the saturation of defect concentration. The mean lifetime and trapping rates are studied for samples deformed up to 58.3%. The concentration of defect range vary from 1015 to 1018cm-3 at the thickness reduction from 2.3 to 58.3%. The dislocation density varies from 108 to 1011cm/cm3.

  19. Detecting Defects in Aircraft Materials by Nuclear Technique (pas)

    NASA Astrophysics Data System (ADS)

    Badawi, Emad. A.

    Positron annihilation spectroscopy (PAS) is one of the nuclear techniques used in material science. The present measurements are used to study the behavior of defect concentration in one of the most important materials — aluminum alloy — which is a 7075 alloy. It has been shown that positrons can become trapped in imperfect locations in solids and their mean lifetime can be influenced by changes in the concentration of such defects. No changes have been observed in the mean lifetime values after the saturation of defect concentration. The mean lifetime and trapping rates were studied for samples deformed up to 58.3%. The concentration of defect range varies (from 1015 to 1018 cm-3) at the thickness reduction, (from 2.3 to 58.3%). The range of the dislocation density varies (from 108 to 1011 cm/cm3).

  20. A history of PAs in the US Public Health Service.

    PubMed

    McKinnon, Mark F; Elizondo, Epifanio; Bonfiglio, Susan M; Hunter-Buskey, Robin N; Placide, Frances P; Bunnell, Rebecca A

    2016-12-01

    Since 1798, the men and women of the Commissioned Corps of the US Public Health Service (USPHS), one of the seven US uniformed services, have served on the front lines of public health. Two hundred years after the start of the USPHS, the first physician assistant (PA) entered the service to carry on the tradition of protecting, promoting, and advancing the health and safety of the nation. These dedicated clinicians are involved in healthcare delivery to underserved and vulnerable populations, disease control and prevention, biomedical research, food and drug regulation, and national and international response efforts for natural and man-made disasters. This article describes how PAs in the Commissioned Corps of the USPHS have impacted the health and safety of not only the United States but also the international community.

  1. The representation of a synoptic-scale weather system in a thermodynamically adjusted version of the ECHAM4 general circulation model

    NASA Astrophysics Data System (ADS)

    Bauer, H.-S.; Wulfmeyer, V.; Bengtsson, L.

    2008-04-01

    In this work, a strong cyclone event is simulated by the general circulation model (GCM) ECHAM4 for studying the representation of weather systems in a climate model. The system developed along the East Coast of the U.S.A. between the 12th and 14th of March 1993. The GCM simulation was started from climatological conditions and was continuously forced to the analyzed state by a thermodynamical adjustment based on the Newtonian relaxation technique (nudging). Relaxation terms for vorticity, divergence, temperature, and the logarithm of surface pressure were added at each model level and time step. The necessary forcing files were calculated from the ECMWF re-analysis (ERA15). No nudging terms were added for the components of the water cycle. Using this forcing, the model was able to reproduce the synoptic-scale features and its temporal development realistically after a spin-up period. This is true even for quantities that are not adjusted to the analysis (e.g., humidity). Detailed comparisons of the model simulations with available observations and the forcing ERA15 were performed for the cyclone case. Systematic errors were detected in the simulation of the thermodynamic state of the atmosphere, which can be traced back to deficiencies in model parametrizations. Differences in the representation of the surface fluxes lead to systematic deviations in near-surface temperature and wind fields. The general situation is very similar in both model representations. Errors were detected in the simulation of the convective boundary layer behind the cold front. The observed strong convective activity is missed both by the adjusted ECHAM4 simulation and ERA15. This is most likely caused by weaknesses in the cloud and convection schemes or by a too strong downdraft compensating the frontal lifting and suppressing the vertical transport of moisture from the boundary layer to higher levels. This work demonstrates for the investigated case the value of simulating single weather

  2. Identification of candidate network hubs involved in metabolic adjustments of rice under drought stress by integrating transcriptome data and genome-scale metabolic network.

    PubMed

    Mohanty, Bijayalaxmi; Kitazumi, Ai; Cheung, C Y Maurice; Lakshmanan, Meiyappan; de los Reyes, Benildo G; Jang, In-Cheol; Lee, Dong-Yup

    2016-01-01

    In this study, we have integrated a rice genome-scale metabolic network and the transcriptome of a drought-tolerant rice line, DK151, to identify the major transcriptional regulators involved in metabolic adjustments necessary for adaptation to drought. This was achieved by examining the differential expressions of transcription factors and metabolic genes in leaf, root and young panicle of rice plants subjected to drought stress during tillering, booting and panicle elongation stages. Critical transcription factors such as AP2/ERF, bZIP, MYB and NAC that control the important nodes in the gene regulatory pathway were identified through correlative analysis of the patterns of spatio-temporal expression and cis-element enrichment. We showed that many of the candidate transcription factors involved in metabolic adjustments were previously linked to phenotypic variation for drought tolerance. This approach represents the first attempt to integrate models of transcriptional regulation and metabolic pathways for the identification of candidate regulatory genes for targeted selection in rice breeding.

  3. Chiropractic Adjustment

    MedlinePlus

    ... structural alignment and improve your body's physical function. Low back pain, neck pain and headache are the most common ... treated. Chiropractic adjustment can be effective in treating low back pain, although much of the research done shows only ...

  4. Adjustment disorder

    MedlinePlus

    ... from other people Skipped heartbeats and other physical complaints Trembling or twitching To have adjustment disorder, you ... ADAM Health Solutions. About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe to RSS Follow ...

  5. Ligand-binding PAS domains in a genomic, cellular, and structural context.

    PubMed

    Henry, Jonathan T; Crosson, Sean

    2011-01-01

    Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting chemotaxis proteins. Although these domains are highly divergent at the primary sequence level, the structures of dozens of PAS domains across a broad section of sequence space have been solved, revealing a conserved three-dimensional architecture. An all-versus-all alignment of 63 PAS structures demonstrates that the PAS domain family forms structural clades on the basis of two principal variables: (a) topological location inside or outside the plasma membrane and (b) the class of small molecule that they bind. The binding of a chemically diverse range of small-molecule metabolites is a hallmark of the PAS domain family. PAS ligand binding either functions as a primary cue to initiate a cellular signaling response or provides the domain with the capacity to respond to secondary physical or chemical signals such as gas molecules, redox potential, or photons. This review synthesizes the current state of knowledge of the structural foundations and evolution of ligand recognition and binding by PAS domains.

  6. An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.

    PubMed

    Ortmayer, Mary; Lafite, Pierre; Menon, Binuraj R K; Tralau, Tewes; Fisher, Karl; Denkhaus, Lukas; Scrutton, Nigel S; Rigby, Stephen E J; Munro, Andrew W; Hay, Sam; Leys, David

    2016-11-24

    The universal Per-ARNT-Sim (PAS) domain functions as a signal transduction module involved in sensing diverse stimuli such as small molecules, light, redox state and gases. The highly evolvable PAS scaffold can bind a broad range of ligands, including haem, flavins and metal ions. However, although these ligands can support catalytic activity, to our knowledge no enzymatic PAS domain has been found. Here we report characterization of the first PAS enzyme: a haem-dependent oxidative N-demethylase. Unrelated to other amine oxidases, this enzyme contains haem, flavin mononucleotide, 2Fe-2S and tetrahydrofolic acid cofactors, and specifically catalyses the NADPH-dependent oxidation of dimethylamine. The structure of the α subunit reveals that it is a haem-binding PAS domain, similar in structure to PAS gas sensors. The dimethylamine substrate forms part of a highly polarized oxygen-binding site, and directly assists oxygen activation by acting as both an electron and proton donor. Our data reveal that the ubiquitous PAS domain can make the transition from sensor to enzyme, suggesting that the PAS scaffold can support the development of artificial enzymes.

  7. Ligand binding PAS domains in a genomic, cellular, and structural context

    PubMed Central

    Henry, Jonathan T.; Crosson, Sean

    2012-01-01

    Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting chemotaxis proteins. Although these domains are highly divergent at the primary sequence level, the structures of dozens of PAS domains across a broad section of sequence space have been solved, revealing a conserved three-dimensional architecture. An all-versus-all alignment of 63 PAS structures demonstrates that the PAS domain family forms structural clades on the basis of two principal variables: (a) topological location inside or outside the plasma membrane and (b) the class of small molecule that they bind. The binding of a chemically diverse range of small-molecule metabolites is a hallmark of the PAS domain family. PAS ligand binding either functions as a primary cue to initiate a cellular signaling response or provides the domain with the capacity to respond to secondary physical or chemical signals such as gas molecules, redox potential, or photons. This review synthesizes the current state of knowledge of the structural foundations and evolution of ligand recognition and binding by PAS domains. PMID:21663441

  8. Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus

    PubMed Central

    2013-01-01

    Background The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequence similarity. To gain greater insight into the evolution of PDC/PAS domains present in the bacterial kingdom and staphylococci in specific, the PDC/PAS domains from the genomic sequences of 48 bacteria, representing 5 phyla, were identified using the sensitive search method based on HMM-to-HMM comparisons (HHblits). Results A total of 1,007 PAS domains and 686 PDC domains distributed over 1,174 proteins were identified. For 28 Gram-positive bacteria, the distribution, organization, and molecular evolution of PDC/PAS domains were analyzed in greater detail, with a special emphasis on the genus Staphylococcus. Compared to other bacteria the staphylococci have relatively fewer proteins (6–9) containing PDC/PAS domains. As a general rule, the staphylococcal genomes examined in this study contain a core group of seven PDC/PAS domain-containing proteins consisting of WalK, SrrB, PhoR, ArlS, HssS, NreB, and GdpP. The exceptions to this rule are: 1) S. saprophyticus lacks the core NreB protein; 2) S. carnosus has two additional PAS domain containing proteins; 3) S. epidermidis, S. aureus, and S. pseudintermedius have an additional protein with two PDC domains that is predicted to code for a sensor histidine kinase; 4) S. lugdunensis has an additional PDC containing protein predicted to be a sensor histidine kinase. Conclusions This comprehensive analysis demonstrates that variation in PDC/PAS domains among bacteria has limited correlations to the genome size or pathogenicity; however, our analysis established that bacteria having a motile phase in their life cycle have significantly more PDC/PAS-containing proteins. In addition, our analysis revealed a

  9. Simulations of Decadal-scale Climate Change Impacts on Agriculture: Attributing Trends in Regional Corn Yields to Physiological Effects Versus Adjusted Farm Management

    NASA Astrophysics Data System (ADS)

    Kucharik, C.

    2003-12-01

    A recent study published in Science in early 2003 [by David Lobell and Gregory Asner, Dept. of Global Ecology, Carnegie Inst. of Washington] highlighted that little effort has been put forth to understand the impacts of previous decadal-scale climate changes on row-crop agriculture. The major obstacle to overcome in quantifying crop response to climate changes over large regions is deciphering between changes attributed to climate change versus technology, land-management and other factors. While the Lobell and Asner study concluded that regional temperature trends potentially contributed to corn and soybean yield trends from 1982-1998, a partitioning of the observed increases between direct physiological effects versus farmer management adjustment to climate was not a goal of their study. As part of this study, an agricultural version of the Integrated BIosphere Simulator (Agro-IBIS), was used to investigate how decadal-scale climate changes may have contributed to corn yield trends across the Mississippi Basin from 1948-2001. The primary objective was to investigate the relative contributions of physiological effects and farmer adjustments in planting date and hybrid choice to long-term corn yield trends. The impacts of advancing technology on agriculture were removed from model simulations so that the impact of weather and farm management decisions (e.g., planting date and hybrid choice) could be separated from observed long-term trends in the USDA crop yield record. Scenarios were used that accounted for smart-farmers, where management adjustments (planting date and/or hybrid) were made in response to climate changes, and for business-as-usual-farmers who continued to plant the same hybrids on the same date during the study period. When average, optimum corn planting dates from the 1950s were compared with the 1990s, significant springtime warming in regions of the northern fringes of the cornbelt (e.g., North Dakota, Minnesota) over the past 40 years have

  10. Changes at the KinA PAS-A Dimerization Interface Influence Histidine Kinase Function

    SciTech Connect

    Lee, James; Tomchick, Diana R.; Brautigam, Chad A.; Machius, Mischa; Kort, Remco; Hellingwerf, Klaas J.; Gardner, Kevin H.

    2008-11-12

    The Bacillus subtilis KinA protein is a histidine protein kinase that controls the commitment of this organism to sporulate in response to nutrient deprivation and several other conditions. Prior studies indicated that the N-terminal Per-ARNT-Sim domain (PAS-A) plays a critical role in the catalytic activity of this enzyme, as demonstrated by the significant decrease of the autophosphorylation rate of a KinA protein lacking this domain. On the basis of the environmental sensing role played by PAS domains in a wide range of proteins, including other bacterial sensor kinases, it has been suggested that the PAS-A domain plays an important regulatory role in KinA function. We have investigated this potential by using a combination of biophysical and biochemical methods to examine PAS-A structure and function, both in isolation and within the intact protein. Here, we present the X-ray crystal structure of the KinA PAS-A domain, showing that it crystallizes as a homodimer using {beta}-sheet/{beta}-sheet packing interactions as observed for several other PAS domain complexes. Notably, we observed two dimers with tertiary and quaternary structure differences in the crystalline lattice, indicating significant structural flexibility in these domains. To confirm that KinA PAS-A also forms dimers in solution, we used a combination of NMR spectroscopy, gel filtration chromatography, and analytical ultracentrifugation, the results of which are all consistent with the crystallographic results. We experimentally tested the importance of several residues at the dimer interface using site-directed mutagenesis, finding changes in the PAS-A domain that significantly alter KinA enzymatic activity in vitro and in vivo. These results support the importance of PAS domains within KinA and other histidine kinases and suggest possible routes for natural or artificial regulation of kinase activity.

  11. Shaft adjuster

    DOEpatents

    Harry, H.H.

    1988-03-11

    Abstract and method for the adjustment and alignment of shafts in high power devices. A plurality of adjacent rotatable angled cylinders are positioned between a base and the shaft to be aligned which when rotated introduce an axial offset. The apparatus is electrically conductive and constructed of a structurally rigid material. The angled cylinders allow the shaft such as the center conductor in a pulse line machine to be offset in any desired alignment position within the range of the apparatus. 3 figs.

  12. Shaft adjuster

    DOEpatents

    Harry, Herbert H.

    1989-01-01

    Apparatus and method for the adjustment and alignment of shafts in high power devices. A plurality of adjacent rotatable angled cylinders are positioned between a base and the shaft to be aligned which when rotated introduce an axial offset. The apparatus is electrically conductive and constructed of a structurally rigid material. The angled cylinders allow the shaft such as the center conductor in a pulse line machine to be offset in any desired alignment position within the range of the apparatus.

  13. Understanding local-scale drivers of biodiversity outcomes in terrestrial protected areas.

    PubMed

    Barnes, Megan D; Craigie, Ian D; Dudley, Nigel; Hockings, Marc

    2016-09-02

    Conservation relies heavily on protected areas (PAs) maintaining their key biodiversity features to meet global biodiversity conservation goals. However, PAs have had variable success, with many failing to fully maintain their biodiversity features. The current literature concerning what drives variability in PA performance is rapidly expanding but unclear, sometimes contradictory, and spread across multiple disciplines. A clear understanding of the drivers of successful biodiversity conservation in PAs is necessary to make them fully effective. Here, we conduct a comprehensive assessment of the current state of knowledge concerning the drivers of biological outcomes within PAs, focusing on those that can be addressed at local scales. We evaluate evidence in support of potential drivers to identify those that enable more successful outcomes and those that impede success and provide a synthetic review. Interactions are discussed where they are known, and we highlight gaps in understanding. We find that elements of PA design, management, and local and national governance challenges, species and system ecology, and sociopolitical context can all influence outcomes. Adjusting PA management to focus on actions and policies that influence the key drivers identified here could improve global biodiversity outcomes.

  14. PAS-cal: a Generic Recombinant Peptide Calibration Standard for Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Breibeck, Joscha; Serafin, Adam; Reichert, Andreas; Maier, Stefan; Küster, Bernhard; Skerra, Arne

    2014-08-01

    We describe the design, preparation, and mass-spectrometric characterization of a new recombinant peptide calibration standard with uniform biophysical and ionization characteristics for mass spectrometry. "PAS-cal" is an artificial polypeptide concatamer of peptide cassettes with varying lengths, each composed of the three small, chemically stable amino acids Pro, Ala, and Ser, which are interspersed by Arg residues to allow site-specific cleavage with trypsin. PAS-cal is expressed at high yields in Escherichia coli as a Small Ubiquitin-like MOdifier (SUMO) fusion protein, which is easily purified and allows isolation of the PAS-cal moiety after SUMO protease cleavage. Upon subsequent in situ treatment with trypsin, the PAS-cal polypeptide yields a set of four defined homogeneous peptides in the range from 2 to 8 kDa with equal mass spacing. ESI-MS analysis revealed a conveniently interpretable raw spectrum, which after deconvolution resulted in a very simple pattern of four peaks with similar ionization signals. MALDI-MS analysis of a PAS-cal peptide mixture comprising both the intact polypeptide and its tryptic fragments revealed not only the four standard peptides but also the singly and doubly charged states of the intact concatamer as well as di- and trimeric adduct ion species between the peptides, thus augmenting the observable m/z range. The advantageous properties of PAS-cal are most likely a result of the strongly hydrophilic and conformationally disordered PEG-like properties of the PAS sequences. Therefore, PAS-cal offers an inexpensive and versatile recombinant peptide calibration standard for mass spectrometry in protein/peptide bioanalytics and proteomics research, the composition of which may be further adapted to fit individual needs.

  15. PerPAS: Topology-Based Single Sample Pathway Analysis Method.

    PubMed

    Liu, Chengyu; Lehtonen, Rainer; Hautaniemi, Sampsa

    2017-03-08

    Identification of intracellular pathways that play key roles in cancer progression and drug resistance is a prerequisite for developing targeted cancer treatments. The era of personalized medicine calls for computational methods that can function with one sample or very small set of samples. Developing such methods is challenging because standard statistical approaches pose several limiting assumptions, such as number of samples, that prevent their application when n approaches to one. We have developed a novel pathway analysis method called PerPAS to estimate pathway activity at a single sample level by integrating pathway topology and transcriptomics data. In addition, PerPAS is able to identify altered pathways between cancer and control samples as well as to identify key nodes that contribute to the pathway activity. In our case study using breast cancer data, we show that PerPAS can identify highly altered pathways that are associated with patient survival. PerPAS identified four pathways that were associated with patient survival and were successfully validated in three independent breast cancer cohorts. In comparison to two other pathway analysis methods that function at a single sample level, PerPAS had superior performance in both synthetic and breast cancer expression datasets. PerPAS is a free R package (http://csbi.ltdk.helsinki.fi/pub/czliu/perpas/).

  16. Light signaling mediated by PAS domain-containing proteins in Xanthomonas campestris pv. campestris.

    PubMed

    Mao, Daqing; Tao, Jun; Li, Chunxia; Luo, Chao; Zheng, Linlin; He, Chaozu

    2012-01-01

    Per-ARNT-Sim (PAS) domains are important signalling modules that possibly monitor changes in various stimuli such as light. For the majority of PAS domains that have been identified by sequence similarity, the biological function of the signalling pathways has not yet been experimentally investigated.Thirty-three PAS proteins were discovered in Xanthomonas campestris pv. campestris(Xcc) by genome/proteome analysis. Thirteen PAS proteins were identified as contributing to light signalling and Xcc growth, motility or virulence using molecular genetics and bioinformatics methods. The PAS domains played important roles in light signalling to regulate the growth, motility and virulence of Xcc. They might be regulated by not only light quality (wavelength)but also quantity (intensity) as potential light-signalling components. Evaluating the light wavelength, three light-signalling types of PAS proteins in Xcc were shown to be involved in blue light signalling, tricolour (blue, red and far red)signalling or red/far-red signalling. This showed that Xcc had evolved a complicated light-signalling system to adapt to a complex environment.

  17. The improved PAS-ELISA method for the diagnosis of the pathogen for banana mosaic heart rot disease.

    PubMed

    Huang, M; Liao, Z

    1996-01-01

    As a fast and practical immunological test, ELISA has been widely applied both in research and diagnosis of plant viruses [1]. In its research utility, PAS-ELISA has been proven as an effective measure to obtain CMV-free micropropagated plantlets. In large-scale micropropagation of banana plantlets, we have been using it in our Quality Control Department to prepare CMV-free and/or TMV-free germplasm. From large-scale testing, we have found that component(s) in banana tissue can cause a nonspecific reaction which severely interferes with the diagnostic results, making the average optical density (OD490nm) value a much higher false positive, leading to an abnormally high percentage loss of the germplasm prepared. The procedure for preparation of the antigen extract from banana tissue has been modified to eliminate the false positive.

  18. Large variations in diurnal and seasonal patterns of sap flux among Aleppo pine trees in semi-arid forest reflect tree-scale hydraulic adjustments

    NASA Astrophysics Data System (ADS)

    Preisler, Yakir; Tatarinov, Fyodor; Rohatyn, Shani; Rotenberg, Eyal; Grünzweig, José M.; Klein, Tamir; Yakir, Dan

    2015-04-01

    Adjustments and adaptations of trees to drought vary across different biomes, species and habitats, with important implications for tree mortality and forest dieback associated with global climate change. The aim of this study was to investigate possible links between the patterns of variations in water flux dynamics and drought resistance in Aleppo pine (Pinus halepensis) trees in a semi-arid stand (Yatir forest, Israel). We measured sap flow (SF) and variations in stem diameter, complemented with short-term campaigns of leaf-scale measurements of water vapour and CO2 gas exchange, branch water potential and hydraulic conductivity, as well as eddy flux measurements of evapotranspiration (ET) from a permanent flux tower at the site. SF rates were well synchronized with ET, reaching maximum rates during midday in all trees during the rainy season (Dec-Apr). However, during the dry season (May-Nov), the daily trend in the rates of SF greatly varied among trees, allowing classification into three tree classes: 1) trees with SF maximum rate constantly occurring in mid-day (12:00-13:00); 2)trees showing a shift to an early morning SF peak (04:00-06:00); and 3) trees shifting their daily SF peak to the evening (16:00-18:00). This classification did not change during the four years study period, between 2010 and 2014. Checking for correlation of tree parameters as DBH, tree height, crown size, and competition indices with rates of SF, indicated that timing of maximum SF in summer was mainly related to tree size (DBH), when large trees tended to have a later SF maximum. Dendrometer measurements indicated that large trees (high DBH) had maximum daily diameter in the morning during summer and winter, while small trees typically had maximum daily diameter during midday and afternoon in winter and summer, respectively. Leaf-scale transpiration (T) measurements showed typical morning peak in all trees, and another peak in the afternoon in large trees only. Different diurnal

  19. Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes.

    PubMed

    Upadhyay, Amit A; Fleetwood, Aaron D; Adebali, Ogun; Finn, Robert D; Zhulin, Igor B

    2016-04-01

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly built computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms. Furthermore, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes.

  20. Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes

    DOE PAGES

    Upadhyay, Amit A.; Fleetwood, Aaron D.; Adebali, Ogun; ...

    2016-04-06

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly builtmore » computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms.Moreover, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes.« less

  1. Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes

    SciTech Connect

    Upadhyay, Amit A.; Fleetwood, Aaron D.; Adebali, Ogun; Finn, Robert D.; Zhulin, Igor B.; Schlessinger, Avner

    2016-04-06

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly built computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms.Moreover, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes.

  2. Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes

    PubMed Central

    Upadhyay, Amit A.; Fleetwood, Aaron D.; Adebali, Ogun; Finn, Robert D.; Zhulin, Igor B.

    2016-01-01

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly built computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms. Furthermore, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes. PMID:27049771

  3. Evaluating the PAS-SIM model using a passive air sampler calibration study for pesticides.

    PubMed

    Restrepo, Andrés Ramírez; Hayward, Stephen J; Armitage, James M; Wania, Frank

    2015-07-01

    The main objective of this study was to evaluate the performance of a model for simulating the uptake of various pesticides on passive air samplers (PAS). From 2006-2007 a series of PAS using XAD-resin were deployed at Egbert, a rural agricultural site in southern Ontario, Canada, to measure the uptake of pesticides for time periods ranging from two months to one year. A continuous increase in sequestered amounts was observed for most pesticides, except for trifluralin and pendimethalin, which could conceivably be subject to substantial degradation inside the sampler. Continuous low-volume active air samples taken during the same period, along with data on weather conditions, allowed for the simulation of the uptake of the pesticides using the model (PAS-SIM). The modelled accumulation of pesticides on the PAS over the deployment period was in good agreement with the experimental data in most cases (i.e., within a factor of two) providing insight into the uptake kinetics of this type of sampler in the field. Passive sampling rates (PSR, m(3) d(-1)) were determined from the empirical data generated for this study using three different methods and compared with the PSRs generated by the model. Overall, the PAS-SIM model, which is capable of accounting for the influence of temperature and wind variations on PSRs, provided reasonable results that range between the three empirical approaches employed and well-established literature values. Further evaluation and application of the PAS-SIM model to explore the potential spatial and temporal variability in PAS uptake kinetics is warranted, particularly for established monitoring sites where detailed meteorological data are more likely to be available.

  4. The Assessment of Family Functions, Dyadic Adjustment, and Parental Attitude in Adolescents with Substance Use Disorder

    PubMed Central

    ÖNGEL ATAR, Ayça; YALÇIN, Özhan; UYGUN, Ersin; ÇİFTÇİ DEMİRCİ, Arzu; ERDOĞAN, Ayten

    2016-01-01

    Introduction Family structure and family attitudes have been reported to be important factors in the development of substance use disorders. In this study, we aimed to assess the relationship between substance use and family functions, parental attitude, and parental dyadic adjustment of adolescents with substance use disorder. Methods The study was conducted on 50 patients, comprising 9 female and 41 male adolescents between the ages of 14 and 18 years, treated at Bakırköy Mental Health Hospital, Substance Abuse Research, Treatment and Education Center for Children Adolescents (ÇEMATEM), Turkey, with the diagnosis of substance use disorder according to DSM-5 and their parents and a control group comprising 50 healthy adolescents without any psychopathology or substance use disorder and their parents. The study was designed as a matched case–control study for age and gender. Sociodemographic Data Form (SDF), Parental Attitude Scale (PAS), Dyadic Adjustment Scale (DAS), and Family Assessment Device (FAD) were applied to both groups. Results When the study and control groups were compared with regard to the PAS, the study group scores determined for “involvement-acceptance,” “psychological autonomy,” and “control-supervision” dimensions were significantly lower than the control group scores. Compared with the control group, dyadic adjustment was lower in terms of “dyadic cohesion,” “dyadic consensus,” and “affectional expression.” Living with biological parents and the togetherness of parents were lower in the study group. “Problem solving,” “communication,” “roles,” “affective responsiveness,” “affective involvement,” “behavior control,” and “general functioning” dimension scores according to FAD were also significantly higher in the study group. Conclusion Compared with togetherness of the controls, the dyadic adjustment of their parents was lower and family functions as perceived by the parents and

  5. Space Data Systems Applications in the iPAS Pathfinder Laboratory

    NASA Technical Reports Server (NTRS)

    Rich, Tom

    2013-01-01

    The iPAS is an integrated hardware/software test and evaluation environment, in support of current and future spacecraft development The iPAS has two main elements. A common avionics, hardware, and software architecture that can be applied over various missions. A common testbed framework that supports integrated hardware/software testing for a variety of applications. The iPAS includes the following (non-flight qualified) components: Core Flight Software (from GSFC). Commercially available Proton and S950 Flight Computer boards. Power and propulsion systems based on representative flight hardware. A realistic flight deck based on the Multi-Purpose Crew Vehicle (MPCV), including realistic flight controls and displays. A Space Data System based on CCSDS protocols.

  6. Norway/United States Design Protective Aircraft Shelter (PAS) Quantity-Distance Program 1/3-Scale Test Series. Volume 3. Appendix B: PAS-3

    DTIC Science & Technology

    1993-08-01

    182.76 520 38782 -1419 31995 182.54 521 38889 -2232 32148 183.98 522 39059 -1825 32293 183.24 523 40253 355 33437 179.39 524 41269 1764 34496 177.07 525...mm) (mm) (mm) (deg) 98 200.1 33024 3871 26490 171.60 520 200.7 38782 -1419 31995 182.54 242 202.3 -17433 -5251 24813 347.78 610 202.5 26780 23478...200.7 38782 -1419 31995 182.54 519 826.6 38830 -1541 32050 182.76 124 502.6 5588 -32056 32079 272.20 500 161.7 38898 1906 32137 176.60 521 695.1 38889

  7. Norway/United States Protective Aircraft Shelter (PAS) Quantity-Distance Program 1/3-Scale Test Series. Volume 1. PAS 1-4 Summary

    DTIC Science & Technology

    1993-08-01

    contained herein, or allow others to do so, for the United States Government purposes. This techuical report has been reviewed by the Public Affairs Office...notify PL/WSSD, Kirtland AFB, NM 87117-5776 to help maintain a current mailing list. This technical report has been reviewed and is approved for...irstructons,. searching existing data sources. gathefrng and maintaining the data needed. and completing and reviewing the cOllection of intormation S•ed

  8. Norway/United States Design Protective Aircraft Shelter (PAS) Quantity-Distance Program 1/3-Scale Test Series. Volume 5. Appendix D: PAS-4

    DTIC Science & Technology

    1993-08-01

    40242 323.68 249 -22070 -32224 43277 311.87 250 -21461 - 31119 42049 312.26 251 -22202 -33189 44087 311.17 252 -18582 -28719 38340 311.49 253 -24310...16794 68374 165.78 145 241.8 -27032 -28514 44259 316.00 250 242.4 -21461 - 31119 42049 312.26 167 242.4 -15590 -17268 28289 327.61 1338 244.3 21096...41929 41993 273.17 250 242.4 -21461 - 31119 42049 312.26 1095 1063.8 -6383 39948 42072 71.71 199 130.0 -34665 -7370 42133 349.93 29 317.2 -28151

  9. Pituitary Adenoma With Paraganglioma/Pheochromocytoma (3PAs) and Succinate Dehydrogenase Defects in Humans and Mice

    PubMed Central

    Xekouki, Paraskevi; Szarek, Eva; Bullova, Petra; Giubellino, Alessio; Quezado, Martha; Mastroyannis, Spyridon A.; Mastorakos, Panagiotis; Wassif, Christopher A.; Raygada, Margarita; Rentia, Nadia; Dye, Louis; Cougnoux, Antony; Koziol, Deloris; Sierra, Maria de La Luz; Lyssikatos, Charalampos; Belyavskaya, Elena; Malchoff, Carl; Moline, Jessica; Eng, Charis; Maher, Louis James; Pacak, Karel; Lodish, Maya

    2015-01-01

    Context: Germline mutations in genes coding succinate dehydrogenase (SDH) subunits A, B, C, and D have been identified in familial paragangliomas (PGLs)/pheochromocytomas (PHEOs) and other tumors. We described a GH-secreting pituitary adenoma (PA) caused by SDHD mutation in a patient with familial PGLs. Additional patients with PAs and SDHx defects have since been reported. Design: We studied 168 patients with unselected sporadic PA and with the association of PAs, PGLs, and/or pheochromocytomas, a condition we named the 3P association (3PAs) for SDHx germline mutations. We also studied the pituitary gland and hormonal profile of Sdhb+/− mice and their wild-type littermates at different ages. Results: No SDHx mutations were detected among sporadic PA, whereas three of four familial cases were positive for a mutation (75%). Most of the SDHx-deficient PAs were either prolactinomas or somatotropinomas. Pituitaries of Sdhb+/− mice older than 12 months had an increased number mainly of prolactin-secreting cells and several ultrastructural abnormalities such as intranuclear inclusions, altered chromatin nuclear pattern, and abnormal mitochondria. Igf-1 levels of mutant mice tended to be higher across age groups, whereas Prl and Gh levels varied according to age and sex. Conclusion: The present study confirms the existence of a new association that we termed 3PAs. It is due mostly to germline SDHx defects, although sporadic cases of 3PAs without SDHx defects also exist. Using Sdhb+/− mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to PA formation. PMID:25695889

  10. Scales

    MedlinePlus

    Scales are a visible peeling or flaking of outer skin layers. These layers are called the stratum ... Scales may be caused by dry skin, certain inflammatory skin conditions, or infections. Eczema , ringworm , and psoriasis ...

  11. Periodic acid-Schiff (PAS) staining of immature platelets in donors.

    PubMed

    Pogorelov, Valery M; Beskorovainova, Victoria Ju; Chanieva, Marem I; Dyagileva, Olga A; Naumova, Iren N; Skedina, Marina A

    2012-01-01

    Glycogen in platelets (PLTs) on smears of peripheral blood of 40 donors was investigated by the periodic acid-Schiff (PAS) method. Three groups were formed. Group 1 was consisted of 21 men undergoing the donor selection procedure. Additionally, 9 first-time donors undergoing plateletpheresis (Group 2) and 10 donors who frequently underwent platelet apheresis (Group 3) were studied as a model of relative thrombocytopenia. Cell sizes were measured with the use of a Image Analyzer "ASPBC" (Russia). The training procedure and classification of PAS-blood PLTs were made on the basis of expert evaluation. In this article, we have established three facts. First, the PAS-positive PLT area was larger than that of the PAS-negative cells (9.5 ± 3.6 sq.mkm vs. 3.9 ± 1.3 sq.mkm, p < 0.001, n = 21). The PAS-positivity of PLTs was 23.1 ± 9.2%. Second, the PAS-positivity correlated (r(S) = 0.63, p < 0.05) with the immature platelets fraction (IPF %), determined using Sysmex XE-2100. The mean IPF was 2.1 ± 1.0% (range 0.3-4.6%). Third, using the IPF% values obtained in Group 1, we found a significantly higher level of IPF in the samples both in Group 2 [mean value 4.2 ± 2.0% (range 1.9-7.0), p < 0.01] and in Group 3 [mean value 5.1 ± 2.5% (range 1.2-8.6), p < 0.004] with relative thrombocytopenia [Group 2: median 198 (95% confidence interval, CI 166-227) vs. median 229 (95% CI 206-267), p < 0.05; Group 3: median 142.5 (95% CI 132-173) vs. median 214.5 (95% CI 196-267), p < 0.01] after plateletpheresis. There was also a significant difference between the pre- and post-plateletpheresis for IPF% in Group 2 and Group 3: median 1.7 (95% CI 1.4-4.0) vs. median 4.0 (95% CI 2.7-5.8), p < 0.05 and median 4.0 (95% CI 2.7-6.0) vs. median 5.1 (95% CI 3.3-6.9), p < 0.01. The increased IPF shows a correlation with the PAS positivity [r(S) = 0.5 (p = 0.14) and r(S) = 0.6 (p = 0.05)] which has a tendency to

  12. Language and Adjustment Scales for the Thematic Apperception Test for Youths 12-17 Years. Vital Health and Statistics, Series 2, No. 62.

    ERIC Educational Resources Information Center

    Neman, Ronald S.; And Others

    The study represents an extension of previous research involving the development of scales for the five-card, orally administered, and tape-recorded version of the Thematic Apperception Test(TAT). Scale development is documented and national norms are presented based on a national probability sample of 1,398 youths administered the Cycle III test…

  13. Crystal structure of the PAS domain of the hEAG potassium channel.

    PubMed

    Tang, Xue; Shao, Juan; Qin, Xiaohong

    2016-08-01

    KCNH voltage-gated potassium channels play critical roles in regulating cellular functions. The channel is composed of four subunits, each of which contains six transmembrane helices forming the central pore. The cytoplasmic parts of the subunits present a Per-Arnt-Sim (PAS) domain at the N-terminus and a cyclic nucleotide-binding homology domain at the C-terminus. PAS domains are conserved from prokaryotes to eukaryotes and are involved in sensing signals and cellular responses. To better understand the functional roles of PAS domains in KCNH channels, the structure of this domain from the human ether-à-go-go channel (hEAG channel) was determined. By comparing it with the structures of the Homo sapiens EAG-related gene (hERG) channel and the Drosophila EAG-like K(+) (dELK) channel and analyzing the structural features of the hEAG channel, it was identified that a hydrophobic patch on the β-sheet may mediate interaction between the PAS domain and other regions of the channel to regulate its functions.

  14. Calibration and application of a passive air sampler (XAD-PAS) for volatile methyl siloxanes.

    PubMed

    Krogseth, Ingjerd S; Zhang, Xianming; Lei, Ying D; Wania, Frank; Breivik, Knut

    2013-05-07

    Because the atmosphere is key to understanding the environmental behavior of volatile methyl siloxanes (VMS), a variety of reliable air sampling methods are needed. The purpose of this study was to calibrate and evaluate an existing, polystyrene-divinylbenzene copolymeric resin-based passive air sampler (XAD-PAS) for VMS. Sixteen XAD-PAS were deployed for 7-98 days at a suburban site in Toronto, Canada, while the VMS concentration in air was monitored by an active sampling method. This calibration and a subsequent field test further allowed for investigation of the temporal and spatial variability of VMS in the region. Uptake in the XAD-PAS of octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and three linear VMS was linear throughout the whole deployment period. Sampling rates were between 0.4 and 0.5 m(3)/day. The XAD-PAS measured ∑VMS concentrations ranged from nondetects in rural areas (n = 3), to 169 ± 49 ng/m(3) in the urban region (n = 21), to levels above 600 ng/m(3) at sewage treatment plants (n = 2). Levels and composition of VMS within the urban area were remarkably uniform in space. Levels, but not composition, were highly variable in time and weakly correlated with temperature, wind speed, and wind direction.

  15. Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS).

    PubMed

    Slichter, Sherrill J; Corson, Jill; Jones, Mary Kay; Christoffel, Todd; Pellham, Esther; Bailey, S Lawrence; Bolgiano, Doug

    2014-01-09

    To evaluate the poststorage viability of apheresis platelets stored for up to 18 days in 80% platelet additive solution (PAS)/20% plasma, 117 healthy subjects donated platelets using the Haemonetics MCS+, COBE Spectra (Spectra), or Trima Accel (Trima) systems. Control platelets from the same subjects were compared with their stored test PAS platelets by radiolabeling their stored and control platelets with either (51)chromium or (111)indium. Trima platelets met Food and Drug Administration poststorage platelet viability criteria for only 7 days vs almost 13 days for Haemonetics platelets; ie, platelet recoveries after these storage times averaged 44 ± 3% vs 49 ± 3% and survivals were 5.4 ± 0.3 vs 4.6 ± 0.3 days, respectively. The differences in storage duration are likely related to both the collection system and the storage bag. The Spectra and Trima platelets were hyperconcentrated during collection, and PAS was added, whereas the Haemonetics platelets were elutriated with PAS, which may have resulted in less collection injury. When Spectra and Trima platelets were stored in Haemonetics' bags, poststorage viability was significantly improved. Platelet viability is better maintained in vitro than in vivo, allowing substantial increases in platelet storage times. However, implementation will require resolution of potential bacterial overgrowth during storage.

  16. Searching for planetary nebulae at the Galactic halo via J-PAS

    NASA Astrophysics Data System (ADS)

    Gonçalves, Denise R.; Aparício-Villegas, T.; Akras, S.; Cortesi, A.; Borges-Fernandes, M.; Daflon, S.; Pereira, C. B.; Lorenz-Martins, S.; Marcolino, W.; Kanaan, A.; Viironen, K.; de Oliveira, C. Mendes; Molino, A.; Ederoclite, A.

    2016-08-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is a narrow-band imaging, very wide field cosmological survey. It will last 5 years and will observe 8500 sq. deg. of the sky. There will be 54 contiguous narrow-band filters of 145Å FWHM, from 3,500 to 10,000Å. Two broad-band filters will be added at the extremes, UV and IR, plus the 3-g, r, and i- SDSS filters. Thus, J-PAS can be an important tool to search for new planetary nebulae (PNe) at the halo, increasing their numbers, because only 14 of them have been convincingly identified in the literature. Halo PNe are able to reveal precious information for the study of stellar evolution and the early chemical conditions of the Galaxy. The characteristic low continuum and intense emission lines of PNe make them good objects to be searched by J-PAS. Though covering a significantly smaller sky area, data from the ALHAMBRA survey were used to test our J-PAS strategy to search for PNe. Our first results are shown in this contribution.

  17. Effects of the bHLH domain on axial coordination of heme in the PAS-A domain of neuronal PAS domain protein 2 (NPAS2): conversion from His119/Cys170 coordination to His119/His171 coordination.

    PubMed

    Uchida, Takeshi; Sagami, Ikuko; Shimizu, Toru; Ishimori, Koichiro; Kitagawa, Teizo

    2012-03-01

    Neuronal PAS domain protein 2 (NPAS2), which is a CO-dependent transcription factor, consists of a basic helix-loop-helix domain (bHLH), and two heme-containing PAS domains (PAS-A and PAS-B). In our previous study on the isolated PAS-A domain, we concluded that His119 and Cys170 are the axial ligands of the ferric heme, while Cys170 is replaced by His171 upon reduction of heme (Uchida et al., J. Biol. Chem. 270, (2005) 21358-21368.). Recently, we characterized the PAS-A domain combined with the N-terminal bHLH domain, and found that some spectroscopic features were different from those of the isolated PAS-A domain (Mukaiyama et al., FEBS J. 273, (2006) 2528-2539.). Therefore, we reinvestigated the coordination structure of heme in the bHLH-PAS-A domain and prepared four histidine and one cysteine mutants. Resonance Raman spectrum of the Cys170Ala mutant is the same as that of wild type with a dominant 6-coordinate heme in the ferric form. In contrast, His119Ala and His171Ala mutants significantly increase amounts of the 5-coordinate species, indicating that His119 and His171, not Cys170, are axial ligands of the ferric heme in the bHLH-PAS-A domain. We had confirmed that the coordination structure of the isolated PAS-A domain is in equilibrium between Cys-Fe-His and His-Fe-His coordinated species but newly found that interaction of the PAS-A domain with the bHLH domain shifts the equilibrium toward the latter structure. Such flexibility in the heme coordination structure seems to be in favor of signal transduction in NPAS2.

  18. J-PAS: The Javalambre Physics of the Accelerated Universe Astrophysical Survey

    NASA Astrophysics Data System (ADS)

    Cepa, J.; Benítez, N.; Dupke, R.; Moles, M.; Sodré, L.; Cenarro, A. J.; Marín-Franch, A.; Taylor, K.; Cristóbal, D.; Fernández-Soto, A.; Mendes de Oliveira, C.; Abramo, L. R.; Alcaniz, J. S.; Overzier, R.; Hernández-Monteagudo, A.; Alfaro, E. J.; Kanaan, A.; Carvano, M.; Reis, R. R. R.; J-PAS Team

    2016-10-01

    The Javalambre Physics of the Accelerated Universe Astrophysical Survey (J-PAS) is a narrow band, very wide field Cosmological Survey to be carried out from the Javalambre Observatory in Spain with a purpose-built, dedicated 2.5 m telescope and a 4.7 sq.deg. camera with 1.2 Gpix. Starting in late 2016, J-PAS will observe 8500 sq.deg. of Northern Sky and measure Δz˜0.003(1+z) photo-z for 9× 107 LRG and ELG galaxies plus several million QSOs, sampling an effective volume of ˜ 14 Gpc3 up to z=1.3 and becoming the first radial BAO experiment to reach Stage IV. J-PAS will detect 7× 105 galaxy clusters and groups, setting constraints on Dark Energy which rival those obtained from its BAO measurements. Thanks to the superb characteristics of the site (seeing ˜ 0.7 arcsec), J-PAS is expected to obtain a deep, sub-arcsec image of the Northern sky, which combined with its unique photo-z precision will produce one of the most powerful cosmological lensing surveys before the arrival of Euclid. J-PAS's unprecedented spectral time domain information will enable a self-contained SN survey that, without the need for external spectroscopic follow-up, will detect, classify and measure σz˜ 0.5 redshifts for ˜ 4000 SNeIa and ˜ 900 core-collapse SNe. The key to the J-PAS potential is its innovative approach: a contiguous system of 54 filters with 145 Å width, placed 100 Å apart over a multi-degree FoV is a powerful redshift machine, with the survey speed of a 4000 multiplexing low resolution spectrograph, but many times cheaper and much faster to build. The J-PAS camera is equivalent to a 4.7 sq.deg. IFU and it will produce a time-resolved, 3D image of the Northern Sky with a very wide range of Astrophysical applications in Galaxy Evolution, the nearby Universe and the study of resolved stellar populations.

  19. Testing for reach-scale adjustments of hydraulic variables to soluble and insoluble strata: Buckeye Creek and Greenbrier River, West Virginia

    NASA Astrophysics Data System (ADS)

    Springer, Gregory S.; Wohl, Ellen E.; Foster, Julie A.; Boyer, Douglas G.

    2003-11-01

    An open question exists as to whether channel geometries and hydraulics are adjusted in bedrock streams with stable, concave profiles in a manner analogous to alluvial rivers. As a test of this problem, a comparison was undertaken of channel geometries and hydraulics among reaches with substrates that are of high mechanical resistance, but of variable chemical resistance. Reaches were selected from Buckeye Creek and Greenbrier River, West Virginia, USA because these streams flow over sandstones, limestones, and shales. The limestones have Selby rock resistance scores similar to those of the sandstones. A total of 13 reaches consisting of between 6 and 26 cross sections were surveyed in the streams. HEC-RAS was used to estimate unit stream power ( ω) and shear stress ( τ) for each reach. The reaches were selected to evaluate the null hypothesis that that ω and τ are equal atop soluble versus insoluble bedrock. Hypothesis tests consisted of paired t-tests and simultaneous, multiple comparisons. Geomorphic setting was included for Greenbrier River because previous studies have suggested that bedrock streams are intimately coupled with hillslopes. Holding geomorphic setting constant, three separate comparisons of ω and τ reveal that these variables are lowest atop soluble substrates in Greenbrier River (significance ≤0.05) and that changes in ω and τ are mediated by changes in channel geometry. Similarly, headwater reaches of Buckeye Creek developed atop shale and sandstone boulders are statistically distinguishable from downstream reaches wherein corrosion of limestone is the primary means of incision. However, comparisons in each stream reveal that channel geometries, ω and τ, are not strictly controlled by bed solubility. For constant substrate solubility along the Greenbrier River, ω and τ are consistently higher where a bedrock cutbank is present or coarse, insoluble sediment enters the channel. The latter is also associated with locally high values

  20. Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2.

    PubMed

    Hennig, Sven; Strauss, Holger M; Vanselow, Katja; Yildiz, Ozkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim; Wolf, Eva

    2009-04-28

    PERIOD proteins are central components of the Drosophila and mammalian circadian clocks. The crystal structure of a Drosophila PERIOD (dPER) fragment comprising two PER-ARNT-SIM (PAS) domains (PAS-A and PAS-B) and two additional C-terminal alpha-helices (alphaE and alphaF) has revealed a homodimer mediated by intermolecular interactions of PAS-A with tryptophane 482 in PAS-B and helix alphaF. Here we present the crystal structure of a monomeric PAS domain fragment of dPER lacking the alphaF helix. Moreover, we have solved the crystal structure of a PAS domain fragment of the mouse PERIOD homologue mPER2. The mPER2 structure shows a different dimer interface than dPER, which is stabilized by interactions of the PAS-B beta-sheet surface including tryptophane 419 (equivalent to Trp482dPER). We have validated and quantitatively analysed the homodimer interactions of dPER and mPER2 by site-directed mutagenesis using analytical gel filtration, analytical ultracentrifugation, and co-immunoprecipitation experiments. Furthermore we show, by yeast-two-hybrid experiments, that the PAS-B beta-sheet surface of dPER mediates interactions with TIMELESS (dTIM). Our study reveals quantitative and qualitative differences between the homodimeric PAS domain interactions of dPER and its mammalian homologue mPER2. In addition, we identify the PAS-B beta-sheet surface as a versatile interaction site mediating mPER2 homodimerization in the mammalian system and dPER-dTIM heterodimer formation in the Drosophila system.

  1. Accurate PSF-matched photometry for the J-PAS survey

    NASA Astrophysics Data System (ADS)

    Jimenez-Teja, Yolanda; Benitez, Txitxo; Dupke, Renato a.

    2015-08-01

    The Javalambre-PAU Astrophysical Survey (J-PAS) is expected to map 8,600 squared-degrees of the sky using 54 narrow and 5 broad band filters. Carried out by a Spanish-Brazilian consortium, the main goal of this survey is to measure Baryon Acoustic Oscillations (BAOs) with photometric redshifts. The expectation is measuring these photometric redshifts with a precision of dz/(1 + z) ~ 0.003 for 100 million galaxies and a few millions of quasars, and reaching an accuracy of dz/(1 + z) ~ 0.01 for other 300 million galaxies. With these numbers, it will be possible to determine w in the Dark Energy (DE) equation of state with an accuracy of < 4%. To achieve such precision and measure the radial BAOs, not only an advanced technical setup but also special data processing tools are required. These tools must be accurate as well as suitable to be implemented in fully automated and computationally efficient algorithms.The factor that most influences the photometric redshift precision is the quality of the photometry. For that reason we have developed a new technique based on the Chebyshev-Fourier bases (CHEFs, Jiménez-Teja & Benítez 2012, ApJ, 745, 150) to obtain a highly precise multicolor photometry without PSF consideration, thus saving a considerable amount of time and circumventing severe problems such as the PSF variability across the images. The CHEFs are a set of mathematical orthonormal bases with different scale and resolution levels, originally designed to fit the surface light distribution of galaxies. They have proved to be able to model any kind of morphology, including spirals, highly elliptical, or irregular galaxies, including isophotal twists and fine substructure. They also fit high signal-to-noise images, lensing arcs and stars with great accuracy. We can calculate optimal, unbiased, total magnitudes directly through these CHEFs models and, thus, colors without needing the PSF.We compare our photometry with widely-used codes such as SExtractor (Bertin

  2. Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

    ERIC Educational Resources Information Center

    Thiébaut, Flora I.; White, Sarah J.; Walsh, Annabel; Klargaard, Solja K.; Wu, Hsuan-Chen; Rees, Geraint; Burgess, Paul W.

    2016-01-01

    43 typically-developed adults and 35 adults with ASD performed a cartoon faux pas test. Adults with ASD apparently over-detected faux pas despite good comprehension abilities, and were generally slower at responding. Signal detection analysis demonstrated that the ASD participants had significantly greater difficulty detecting whether a cartoon…

  3. Searching for planetary nebulae at the Galactic halo via J-PAS and J-PLUS

    NASA Astrophysics Data System (ADS)

    Goncalves, Denise R.; Aparício-Villegas, Teresa; Akras, Stavros; Borges Fernandes, Marcelo; J-PAS Collaboration

    2015-08-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) is a narrow-band imaging, very wide field cosmological survey to be carried out from a dedicated 2.5m telescope and a 4.7 sq.deg camera with 1.2Gpix. It will last 5 years and will observe 8500 sq.deg of Northern sky to a 5-σ magnitude depth for point sources, equivalent to i ~23.3 over an aperture of 2 arcsec2. The J-PAS filter system consists of 54 contiguous narrow band filters of 145-Å FWHM, from 3,500 to 10,000Å. Two broad-band filters will be added at the extremes, UV and IR, plus 3 SDSS g, r, and i filters. The Javalambre Photometric Local Universe Survye (J-PLUS) will be an auxiliary survey ofJ-PAS (mainly for calibration) with a dedicated 0.80m telescope. J-PLUS comprises 12 filters, including g, r, i and z SDSS ones. Though about 2,500 planetary nebulae (PNe, confirmed spectroscopically) are known in the Galaxy, only 14 objects have been convincingly identified as halo PNe. They were classified as such from their location, kinematics and chemistry. Halo PNe are able to reveal precious information for the study of low- and intermediate-mass star evolution and the early chemical conditions of the Galaxy. The characteristic low continuum and intense line emissions of PNe make them good objects to be searched by J-PAS, and even by J-PLUS. For instance, the halo PNe BoBn 1, DdDm 1 and PS 1, located somewhere between 11 and 24 kpc from the Sun, have B magnitudes of 16, 14 and 13.4, respectively. Such values are easily encompassed by J-PAS/J-PLUS, given the typical limit magnitude of the survey. Though covering a significantly smaller sky area, data from the ALHAMBRA survey were used to test our J-PAS/J-PLUS strategy to search for PNe. Our first results will be shown in this poster.

  4. Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

    PubMed

    Thiébaut, Flora I; White, Sarah J; Walsh, Annabel; Klargaard, Solja K; Wu, Hsuan-Chen; Rees, Geraint; Burgess, Paul W

    2016-01-01

    43 typically-developed adults and 35 adults with ASD performed a cartoon faux pas test. Adults with ASD apparently over-detected faux pas despite good comprehension abilities, and were generally slower at responding. Signal detection analysis demonstrated that the ASD participants had significantly greater difficulty detecting whether a cartoon depicted a faux pas and showed a liberal response bias. Test item analysis demonstrated that the ASD group were not in agreement with a reference control group (n = 69) about which non-faux pas items were most difficult. These results suggest that the participants with ASD had a primary problem with faux pas detection, but that there is another factor at work, possibly compensatory, that relates to their choice of a liberal response criterion.

  5. Using the Social, Attitudinal, Familial, and Environmental (S.A.F.E.) Acculturation Stress Scale to Assess the Adjustment Needs of Hispanic College Students.

    ERIC Educational Resources Information Center

    Fuertes, Jairo N.; Westbrook, Franklin D.

    1996-01-01

    Reexamined the validity and reliability of the 24-item S.A.F.E. scale and found it to be a reliable measure of Hispanics' acculturation stress. Also studied the effect of generational status, gender, and socioeconomic status on the levels of acculturation stress experienced by this sample. (RJM)

  6. Practical Analysis of materials with depth varying compositions using FT-IR photoacoustic spectroscopy (PAS)

    SciTech Connect

    J.F. McClelland; R.W. Jones; Siquan Luo

    2004-09-30

    FT-IR photoacoustic spectroscopy (PAS) is discussed as a nondestructive method to probe the molecular composition of materials versus depth on the basis of the analysis of layers of experimentally controllable thickness, which are measured from the sample surface to depths of some tens of micrometers, depending on optical and thermal properties. Computational methods are described to process photoacoustic amplitude and phase spectra for both semi-quantitative and quantitative depth analyses. These methods are demonstrated on layered and gradient samples.

  7. Extracytoplasmic PAS-like domains are common in signal transduction proteins.

    SciTech Connect

    Schiffer, M.; Chang, C.; Tesar, C.; Gu, M.; Babnigg, G.; Joachimiak, A.; Pokkuluri, P. R.; Szurmant, H.; Biosciences Division; Scripps Research Inst.

    2010-02-01

    We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain.

  8. Extracytoplasmic pas-like domains are common in signal transduction proteins. ;

    SciTech Connect

    Chang, C.; Tesar, C.; Gu, M.; Babnigg, G.; Joachimiak, A.; Pokkuluri, P. R.; Szurmant, H.; Schiffer, M.

    2010-02-01

    We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain.

  9. Large-scale synthesis of monodisperse SiC nanoparticles with adjustable size, stoichiometric ratio and properties by fluidized bed chemical vapor deposition

    NASA Astrophysics Data System (ADS)

    Liu, Rongzheng; Liu, Malin; Chang, Jiaxing

    2017-02-01

    A facile fluidized bed chemical vapor deposition method was proposed for the synthesis of monodisperse SiC nanoparticles by using the single precursor of hexamethyldisilane (HMDS). SiC nanoparticles with average particle size from 10 to 200 nm were obtained by controlling the temperature and the gas ratio. An experimental chemical vapor deposition phase diagram of SiC in the HMDS-Ar-H2 system was obtained and three regions of SiC-Si, SiC and SiC-C can be distinguished. The BET surface area and the photoluminescence properties of the SiC nanoparticles can be adjusted by changing the nanoparticle size. For the SiC nanospheres with free carbon, a novel hierarchical structure with 5 8 nm SiC nanoparticles embedded into the graphite matrix was obtained. The advantages of fluidized bed technology for the preparation of SiC nanoparticles were proposed based on the features of homogenous reaction zone, narrow temperature distribution, ultra-short reactant residence time and mass production.

  10. Child Adjustment and Parent Efficacy Scale-Developmental Disability (CAPES-DD): First psychometric evaluation of a new child and parenting assessment tool for children with a developmental disability.

    PubMed

    Emser, Theresa S; Mazzucchelli, Trevor G; Christiansen, Hanna; Sanders, Matthew R

    2016-01-01

    This study examined the psychometric properties of the Child Adjustment and Parent Efficacy Scale-Developmental Disability (CAPES-DD), a brief inventory for assessing emotional and behavioral problems of children with developmental disabilities aged 2- to 16-years, as well as caregivers' self-efficacy in managing these problems. A sample of 636 parents participated in the study. Children's ages ranged from 2 to 15. Exploratory and confirmatory factor analyses supported a 21-item, three-factor model of CAPES-DD child adjustment with 13 items describing behavioral (10 items) and emotional (3 items) problems and 8 items describing prosocial behavior. Three additional items were included due to their clinical usefulness and contributed to a Total Problem Score. Factor analyses also supported a 16-item, one factor model of CAPES-DD self-efficacy. Psychometric evaluation of the CAPES-DD revealed scales had satisfactory to very good internal consistency, as well as very good convergent and predictive validity. The instrument is to be in the public domain and free for practitioners and researchers to use. Potential uses of the measure and implications for future validation studies are discussed.

  11. PAS/POLY-HAMP SIGNALING IN AER-2, A SOLUBLE HEME-BASED SENSOR

    PubMed Central

    Watts, Kylie J; Taylor, Barry L; Johnson, Mark S

    2011-01-01

    SUMMARY Poly-HAMP domains are widespread in bacterial chemoreceptors, but previous studies have focused on receptors with single HAMP domains. The Pseudomonas aeruginosa chemoreceptor, Aer-2, has an unusual domain architecture consisting of a PAS sensing domain sandwiched between three N-terminal and two C-terminal HAMP domains, followed by a conserved kinase control module. The structure of the N-terminal HAMP domains was recently solved, making Aer-2 the first protein with resolved poly-HAMP structure. The role of Aer-2 in P. aeruginosa is unclear, but here we show that Aer-2 can interact with the chemotaxis system of Escherichia coli to mediate repellent responses to oxygen, carbon monoxide and nitric oxide. Using this model system to investigate signaling and poly-HAMP function, we determined that the Aer-2 PAS domain binds penta-coordinated b-type heme and that reversible signaling requires four of the five HAMP domains. Deleting HAMP 2 and/or 3 resulted in a kinase-off phenotype, whereas deleting HAMP 4 and/or 5 resulted in a kinase-on phenotype. Overall, these data support a model in which ligand-bound Aer-2 PAS and HAMP 2 and 3 act together to relieve inhibition of the kinase control module by HAMP 4 and 5, resulting in the kinase-on state of the Aer-2 receptor. PMID:21255112

  12. Laser diode bars based on strain-compensated AlGaPAs/GaAs heterostructures

    SciTech Connect

    Marmalyuk, Aleksandr A; Ladugin, M A; Yarotskaya, I V; Panarin, V A; Mikaelyan, G T

    2012-01-31

    Traditional (in the AlGaAs/GaAs system) and phosphorus-compensated (in the AlGaAs/AlGaPAs/GaAs system) laser heterostructures emitting at a wavelength of 850 nm are grown by MOVPE and studied. Laser diode bars are fabricated and their output characteristics are studied. The method used to grow heterolayers allowed us to control (minimise) mechanical stresses in the AlGaPAs/GaAs laser heterostructure, which made it possible to keep its curvature at the level of the initial curvature of the substrate. It is shown that the use of a compensated AlGaPAs/GaAs heterostructure improves the linear distribution of emitting elements in the near field of laser diode arrays and allows the power - current characteristic to retain its slope at high pump currents owing to a uniform contact of all emitting elements with the heat sink. The radius of curvature of the grown compensated heterostructures turns out to be smaller than that of traditional heterostructures.

  13. Phage-Antibiotic Synergy (PAS): beta-lactam and quinolone antibiotics stimulate virulent phage growth.

    PubMed

    Comeau, André M; Tétart, Françoise; Trojet, Sabrina N; Prère, Marie-Françoise; Krisch, H M

    2007-08-29

    Although the multiplication of bacteriophages (phages) has a substantial impact on the biosphere, comparatively little is known about how the external environment affects phage production. Here we report that sub-lethal concentrations of certain antibiotics can substantially stimulate the host bacterial cell's production of some virulent phage. For example, a low dosage of cefotaxime, a cephalosporin, increased an uropathogenic Escherichia coli strain's production of the phage PhiMFP by more than 7-fold. We name this phenomenon Phage-Antibiotic Synergy (PAS). A related effect was observed in diverse host-phage systems, including the T4-like phages, with beta-lactam and quinolone antibiotics, as well as mitomycin C. A common characteristic of these antibiotics is that they inhibit bacterial cell division and trigger the SOS system. We therefore examined the PAS effect within the context of the bacterial SOS and filamentation responses. We found that the PAS effect appears SOS-independent and is primarily a consequence of cellular filamentation; it is mimicked by cells that constitutively filament. The fact that completely unrelated phages manifest this phenomenon suggests that it confers an important and general advantage to the phages.

  14. Principles of Ligand Binding within a Completely Buried Cavity in HIF2[alpha] PAS-B

    SciTech Connect

    Key, Jason; Scheuermann, Thomas H.; Anderson, Peter C.; Daggett, Valerie; Gardner, Kevin H.

    2010-04-19

    Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors responsible for the metazoan hypoxia response and promote tumor growth, metastasis, and resistance to cancer treatment. The C-terminal Per-ARNT-Sim (PAS) domain of HIF2{alpha} (HIF2{alpha} PAS-B) contains a preformed solvent-inaccessible cavity that binds artificial ligands that allosterically perturb the formation of the HIF heterodimer. To better understand how small molecules bind within this domain, we examined the structures and equilibrium and transition-state thermodynamics of HIF2{alpha} PAS-B with several artificial ligands using isothermal titration calorimetry, NMR exchange spectroscopy, and X-ray crystallography. Rapid association rates reveal that ligand binding is not dependent upon a slow conformational change in the protein to permit ligand access, despite the closed conformation observed in the NMR and crystal structures. Compensating enthalpic and entropic contributions to the thermodynamic barrier for ligand binding suggest a binding-competent transition state characterized by increased structural disorder. Finally, molecular dynamics simulations reveal conversion between open and closed conformations of the protein and pathways of ligand entry into the binding pocket.

  15. Noninvasive glucose sensing in scattering media using OCT, PAS, and TOF techniques

    NASA Astrophysics Data System (ADS)

    Alarousu, Erkki; Hast, Jukka T.; Kinnunen, Matti T.; Kirillin, Mikhail Y.; Myllyla, Risto A.; Plucinski, Jerzy; Popov, Alexey P.; Priezzhev, Alexander V.; Prykari, Tuukka; Saarela, Juha; Zhao, Zuomin

    2004-08-01

    In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

  16. A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues

    PubMed Central

    Mann, Thomas H.; Seth Childers, W.; Blair, Jimmy A.; Eckart, Michael R.; Shapiro, Lucy

    2016-01-01

    All cells must integrate sensory information to coordinate developmental events in space and time. The bacterium Caulobacter crescentus uses two-component phospho-signalling to regulate spatially distinct cell cycle events through the master regulator CtrA. Here, we report that CckA, the histidine kinase upstream of CtrA, employs a tandem-PAS domain sensor to integrate two distinct spatiotemporal signals. Using CckA reconstituted on liposomes, we show that one PAS domain modulates kinase activity in a CckA density-dependent manner, mimicking the stimulation of CckA kinase activity that occurs on its transition from diffuse to densely packed at the cell poles. The second PAS domain interacts with the asymmetrically partitioned second messenger cyclic-di-GMP, inhibiting kinase activity while stimulating phosphatase activity, consistent with the selective inactivation of CtrA in the incipient stalked cell compartment. The integration of these spatially and temporally regulated signalling events within a single signalling receptor enables robust orchestration of cell-type-specific gene regulation. PMID:27117914

  17. [Parental alienation syndrome (PAS): unknown in medical settings, endemic in courts].

    PubMed

    Pignotti, Maria Serenella

    2013-02-01

    A purposed syndrome of so-called parental alienation (PAS), unsupported by any evidence-based data, unknown in medical settings, unquoted in medical books, absent in DSM and ICD, never demonstrated by controlled studies published in high scientific level journals, is rampant in Courts where it can lead to loose parental custody. During a divorce trial, almost always the mothers and the children, become joint in a sort of folie au deux, in a denigration campaign of ex-husband/father. From a review on this issue it seems evident its theoretical roots lie on a theory that justify gender violence and children sexual abuse. The bias that both of them are layers and that he children have not autonomy block their possibility of any defence in front of a Court. In severe cases, PAS becomes a new and efficient tool of intra-familiar violence. The treatment of severe cases is to stop any contact between mother and children. The resort to PAS in Courts must be strongly rejected.

  18. Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain

    PubMed Central

    Harley, Carol A.; Starek, Greg; Jones, David K.; Fernandes, Andreia S.; Robertson, Gail A.; Morais-Cabral, João H.

    2016-01-01

    The human human ether-à-go-go–related gene (hERG) potassium channel plays a critical role in the repolarization of the cardiac action potential. Changes in hERG channel function underlie long QT syndrome (LQTS) and are associated with cardiac arrhythmias and sudden death. A striking feature of this channel and KCNH channels in general is the presence of an N-terminal Per-Arnt-Sim (PAS) domain. In other proteins, PAS domains bind ligands and modulate effector domains. However, the PAS domains of KCNH channels are orphan receptors. We have uncovered a family of positive modulators of hERG that specifically bind to the PAS domain. We generated two single-chain variable fragments (scFvs) that recognize different epitopes on the PAS domain. Both antibodies increase the rate of deactivation but have different effects on channel activation and inactivation. Importantly, we show that both antibodies, on binding to the PAS domain, increase the total amount of current that permeates the channel during a ventricular action potential and significantly reduce the action potential duration recorded in human cardiomyocytes. Overall, these molecules constitute a previously unidentified class of positive modulators and establish that allosteric modulation of hERG channel function through ligand binding to the PAS domain can be attained. PMID:27516548

  19. The effect of simultaneous contractions of ipsilateral muscles on changes in corticospinal excitability induced by paired associative stimulation (PAS).

    PubMed

    Kennedy, Niamh C; Carson, Richard G

    2008-11-07

    Consideration was given to means of increasing the reliability and muscle specificity of paired associative stimulation (PAS) by utilising the phenomenon of crossed-facilitation. Eight participants completed three separate sessions: isometric flexor contractions of the left wrist at 20% of maximum voluntary contraction (MVC) simultaneously with PAS (20s intervals; 14 min duration) delivered at the right median nerve and left primary motor cortex (M1); isometric contractions at 20% of MVC; and PAS only (14 min). Eight further participants completed two sessions of longer duration PAS (28 min): either alone or in conjunction with flexion contractions of the left wrist. Thirty motor potentials (MEPs) were evoked in the right flexor (rFCR) and extensor (rECR) carpi radialis muscles by magnetic stimulation of left M1 prior to the interventions, immediately post-intervention, and 10 min post-intervention. Both 14 and 28 min of combined PAS and (left wrist flexion) contractions resulted in reliable increases in rFCR MEP amplitude, which were not present in rECR. In the PAS only conditions, 14 min of stimulation gave rise to unreliable increases in MEP amplitudes in rFCR and rECR, whereas 28 min of PAS induced small (unreliable) changes only for rFCR. These results support the conclusion that changes in the excitability of the corticospinal pathway induced by PAS interact with those associated with contraction of the muscles ipsilateral to the site of cortical stimulation. Furthermore, focal contractions applied by the opposite limb increase the extent and muscle specificity of the induced changes in excitability associated with PAS.

  20. Scales

    ScienceCinema

    Murray Gibson

    2016-07-12

    Musical scales involve notes that, sounded simultaneously (chords), sound good together. The result is the left brain meeting the right brain — a Pythagorean interval of overlapping notes. This synergy would suggest less difference between the working of the right brain and the left brain than common wisdom would dictate. The pleasing sound of harmony comes when two notes share a common harmonic, meaning that their frequencies are in simple integer ratios, such as 3/2 (G/C) or 5/4 (E/C).

  1. Scales

    SciTech Connect

    Murray Gibson

    2007-04-27

    Musical scales involve notes that, sounded simultaneously (chords), sound good together. The result is the left brain meeting the right brain — a Pythagorean interval of overlapping notes. This synergy would suggest less difference between the working of the right brain and the left brain than common wisdom would dictate. The pleasing sound of harmony comes when two notes share a common harmonic, meaning that their frequencies are in simple integer ratios, such as 3/2 (G/C) or 5/4 (E/C).

  2. Burkholderia cepacia complex Phage-Antibiotic Synergy (PAS): antibiotics stimulate lytic phage activity.

    PubMed

    Kamal, Fatima; Dennis, Jonathan J

    2015-02-01

    The Burkholderia cepacia complex (Bcc) is a group of at least 18 species of Gram-negative opportunistic pathogens that can cause chronic lung infection in cystic fibrosis (CF) patients. Bcc organisms possess high levels of innate antimicrobial resistance, and alternative therapeutic strategies are urgently needed. One proposed alternative treatment is phage therapy, the therapeutic application of bacterial viruses (or bacteriophages). Recently, some phages have been observed to form larger plaques in the presence of sublethal concentrations of certain antibiotics; this effect has been termed phage-antibiotic synergy (PAS). Those reports suggest that some antibiotics stimulate increased production of phages under certain conditions. The aim of this study is to examine PAS in phages that infect Burkholderia cenocepacia strains C6433 and K56-2. Bcc phages KS12 and KS14 were tested for PAS, using 6 antibiotics representing 4 different drug classes. Of the antibiotics tested, the most pronounced effects were observed for meropenem, ciprofloxacin, and tetracycline. When grown with subinhibitory concentrations of these three antibiotics, cells developed a chain-like arrangement, an elongated morphology, and a clustered arrangement, respectively. When treated with progressively higher antibiotic concentrations, both the sizes of plaques and phage titers increased, up to a maximum. B. cenocepacia K56-2-infected Galleria mellonella larvae treated with phage KS12 and low-dose meropenem demonstrated increased survival over controls treated with KS12 or antibiotic alone. These results suggest that antibiotics can be combined with phages to stimulate increased phage production and/or activity and thus improve the efficacy of bacterial killing.

  3. Burkholderia cepacia Complex Phage-Antibiotic Synergy (PAS): Antibiotics Stimulate Lytic Phage Activity

    PubMed Central

    Kamal, Fatima

    2014-01-01

    The Burkholderia cepacia complex (Bcc) is a group of at least 18 species of Gram-negative opportunistic pathogens that can cause chronic lung infection in cystic fibrosis (CF) patients. Bcc organisms possess high levels of innate antimicrobial resistance, and alternative therapeutic strategies are urgently needed. One proposed alternative treatment is phage therapy, the therapeutic application of bacterial viruses (or bacteriophages). Recently, some phages have been observed to form larger plaques in the presence of sublethal concentrations of certain antibiotics; this effect has been termed phage-antibiotic synergy (PAS). Those reports suggest that some antibiotics stimulate increased production of phages under certain conditions. The aim of this study is to examine PAS in phages that infect Burkholderia cenocepacia strains C6433 and K56-2. Bcc phages KS12 and KS14 were tested for PAS, using 6 antibiotics representing 4 different drug classes. Of the antibiotics tested, the most pronounced effects were observed for meropenem, ciprofloxacin, and tetracycline. When grown with subinhibitory concentrations of these three antibiotics, cells developed a chain-like arrangement, an elongated morphology, and a clustered arrangement, respectively. When treated with progressively higher antibiotic concentrations, both the sizes of plaques and phage titers increased, up to a maximum. B. cenocepacia K56-2-infected Galleria mellonella larvae treated with phage KS12 and low-dose meropenem demonstrated increased survival over controls treated with KS12 or antibiotic alone. These results suggest that antibiotics can be combined with phages to stimulate increased phage production and/or activity and thus improve the efficacy of bacterial killing. PMID:25452284

  4. Second Annual Maintenance, Inspection, and Test Report for PAS-1 Cask Certification for Shipping Payload B

    SciTech Connect

    KELLY, D.J.

    2000-10-09

    The Nuclear Packaging, Inc. (NuPac), PAS-1 cask is required to undergo annual maintenance and inspections to retain certification in accordance with U.S. Department of Energy (DOE) Certificate of Compliance USA/9184B(U) (Appendix A). The packaging configuration being tested and maintained is the NuPac PAS-1 cask for Payload B. The intent of the maintenance and inspections is to ensure the packaging remains in unimpaired physical condition. Two casks, serial numbers 2162-026 and 2162-027, were maintained, inspected, and tested at the 306E Development, Fabrication, and Test Laboratory, located at the Hanford Site's 300 Area. Waste Management Federal Services, Inc. (WMFS), a subsidiary of GTS Duratek, was in charge of the maintenance and testing. Cogema Engineering Corporation (Cogema) directed the operations in the test facility. The maintenance, testing, and inspections were conducted successfully with both PAS-1 casks. The work conducted on the overpacks included weighing, gasket replacement, and plastic pipe plug and foam inspections. The work conducted on the secondary containment vessel (SCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, and a helium leak test. The work conducted on the primary containment vessel (PCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, dimensional inspection of the vessel bottom, a helium leak test, and dye penetrant inspection of the welds. The vermiculite material used in the cask rack assembly was replaced.

  5. Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission

    PubMed Central

    2013-01-01

    Background In bacteria, signal-transduction two-component systems are major players for adaptation to environmental stimuli. The perception of a chemical or physical signal by a sensor-kinase triggers its autophosphorylation. The phosphoryl group is then transferred to the cognate response regulator, which mediates the appropriate adaptive response. Virulence of the whooping cough agent Bordetella pertussis is controlled by the two-component system BvgAS. Atypically, the sensor-kinase BvgS is active without specific stimuli at 37°C in laboratory conditions and is inactivated by the addition of negative chemical modulators. The structure of BvgS is complex, with two tandem periplasmic Venus flytrap domains and a cytoplasmic PAS domain that precedes the kinase domain, which is followed by additional phosphotransfer domains. PAS domains are small, ubiquitous sensing or regulatory domains. The function of the PAS domain in BvgS remains unknown. Results We showed that recombinant BvgS PAS proteins form dimers that are stabilized by α helical regions flanking the PAS core. A structural model of the PAS domain dimer was built and probed by site-directed mutagenesis and by biochemical and functional analyses. Although we found no ligands for the PAS domain cavity, its integrity is required for signaling. We also showed that the structural stability of the PAS core and its proper coupling to its flanking N- and C-terminal α helices are crucial for BvgS activity. Conclusions We propose that a major function of the BvgS PAS domain is to maintain conformational signals arising from mechanical strain generated by the periplasmic domain. The tight structure of the PAS core and its connections with the upstream and downstream helices ensure signaling to the kinase domain, which determines BvgS activity. Many mild substitutions that map to the PAS domain keep BvgS active but make it unresponsive to negative modulators, supporting that modulation increases conformational strain

  6. Retaining large and adjustable elastic strains of kilogram-scale Nb nanowires [Better Superconductor by Elastic Strain Engineering: Kilogram-scale Free-Standing Niobium Metal Composite with Large Retained Elastic Strains

    SciTech Connect

    Hao, Shijie; Cui, Lishan; Wang, Hua; Jiang, Daqiang; Liu, Yinong; Yan, Jiaqiang; Ren, Yang; Han, Xiaodong; Brown, Dennis E.; Li, Ju

    2016-02-10

    Crystals held at ultrahigh elastic strains and stresses may exhibit exceptional physical and chemical properties. Individual metallic nanowires can sustain ultra-large elastic strains of 4-7%. However, retaining elastic strains of such magnitude in kilogram-scale nanowires is challenging. Here, we find that under active load, ~5.6% elastic strain can be achieved in Nb nanowires in a composite material. Moreover, large tensile (2.8%) and compressive (-2.4%) elastic strains can be retained in kilogram-scale Nb nanowires when the composite is unloaded to a free-standing condition. It is then demonstrated that the retained tensile elastic strains of Nb nanowires significantly increase their superconducting transition temperature and critical magnetic fields, corroborating ab initio calculations based on BCS theory. This free-standing nanocomposite design paradigm opens new avenues for retaining ultra-large elastic strains in great quantities of nanowires and elastic-strain-engineering at industrial scale.

  7. Long-Term Large-Scale Bias-Adjusted Precipitation Estimates at High Spatial and Temporal Resolution Derived from the National Mosaic and Multi-Sensor QPE (NMQ/Q2) Precipitation Reanalysis over CONUS

    NASA Astrophysics Data System (ADS)

    Prat, O. P.; Nelson, B. R.; Stevens, S. E.; Seo, D. J.; Kim, B.

    2014-12-01

    The processing of radar-only precipitation via the reanalysis from the National Mosaic and Multi-Sensor Quantitative (NMQ/Q2) based on the WSR-88D Next-generation Radar (Nexrad) network over Continental United States (CONUS) is nearly completed for the period covering from 2000 to 2012. This important milestone constitutes a unique opportunity to study precipitation processes at a 1-km spatial resolution for a 5-min temporal resolution. However, in order to be suitable for hydrological, meteorological and climatological applications, the radar-only product needs to be bias-adjusted and merged with in-situ rain gauge information. Rain gauge networks such as the Hydrometeorological Automated Data System (HADS), the Automated Surface Observing Systems (ASOS), the Climate Reference Network (CRN), and the Global Historical Climatology Network - Daily (GHCN-D) are used to adjust for those biases and to merge with the radar only product to provide a multi-sensor estimate. The challenges related to incorporating non-homogeneous networks over a vast area and for a long-term record are enormous. Among the challenges we are facing are the difficulties incorporating differing resolution and quality surface measurements to adjust gridded estimates of precipitation. Another challenge is the type of adjustment technique. After assessing the bias and applying reduction or elimination techniques, we are investigating the kriging method and its variants such as simple kriging (SK), ordinary kriging (OK), and conditional bias-penalized Kriging (CBPK) among others. In addition we hope to generate estimates of uncertainty for the gridded estimate. In this work the methodology is presented as well as a comparison between the radar-only product and the final multi-sensor QPE product. The comparison is performed at various time scales from the sub-hourly, to annual. In addition, comparisons over the same period with a suite of lower resolution QPEs derived from ground based radar

  8. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity

    SciTech Connect

    Marreilha dos Santos, A.P.; Lucas, Rui L.; Andrade, Vanda; Mateus, M. Luísa; Milatovic, Dejan; Aschner, Michael; Batoreu, M. Camila

    2012-02-01

    Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of the present study was to investigate the efficacy of ebselen (Ebs) and para-aminosalicylic acid (PAS) in attenuating the neurotoxic effects of Mn in an in vivo rat model. Exposure biomarkers, inflammatory and oxidative stress biomarkers, as well as behavioral parameters were evaluated. Co-treatment with Mn plus Ebs or Mn plus PAS caused a significant decrease in blood and brain Mn concentrations (compared to rats treated with Mn alone), concomitant with reduced brain E{sub 2} prostaglandin (PGE{sub 2}) and enhanced brain glutathione (GSH) levels, decreased serum prolactin (PRL) levels, and increased ambulation and rearing activities. Taken together, these results establish that both PAS and Ebs are efficacious in reducing Mn body burden, neuroinflammation, oxidative stress and locomotor activity impairments in a rat model of Mn-induced toxicity. -- Highlights: ► The manuscript is unique in its approach to the neurotoxicity of Mn. ► The manuscript incorporates molecular, cellular and functional (behavioral) analyses. ► Both PAS and Ebs are effective in restoring Mn behavioral function. ► Both PAS and Ebs are effective in reducing Mn-induced oxidative stress. ► Both PAS and Ebs led to a decrease in Mn-induced neuro-inflammation.

  9. Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.

    PubMed

    Scheuermann, Thomas H; Tomchick, Diana R; Machius, Mischa; Guo, Yan; Bruick, Richard K; Gardner, Kevin H

    2009-01-13

    The hypoxia-inducible factor (HIF) basic helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator (ARNT)-Sim (bHLH-PAS) transcription factors are master regulators of the conserved molecular mechanism by which metazoans sense and respond to reductions in local oxygen concentrations. In humans, HIF is critically important for the sustained growth and metastasis of solid tumors. Here, we describe crystal structures of the heterodimer formed by the C-terminal PAS domains from the HIF2alpha and ARNT subunits of the HIF2 transcription factor, both in the absence and presence of an artificial ligand. Unexpectedly, the HIF2alpha PAS-B domain contains a large internal cavity that accommodates ligands identified from a small-molecule screen. Binding one of these ligands to HIF2alpha PAS-B modulates the affinity of the HIF2alpha:ARNT PAS-B heterodimer in vitro. Given the essential role of PAS domains in forming active HIF heterodimers, these results suggest a presently uncharacterized ligand-mediated mechanism for regulating HIF2 activity in endogenous and clinical settings.

  10. Artificial ligand binding within the HIF2[alpha] PAS-B domain of the HIF2 transcription factor

    SciTech Connect

    Scheuermann, Thomas H.; Tomchick, Diana R.; Machius, Mischa; Guo, Yan; Bruick, Richard K.; Gardner, Kevin H.

    2009-05-12

    The hypoxia-inducible factor (HIF) basic helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator (ARNT)-Sim (bHLH-PAS) transcription factors are master regulators of the conserved molecular mechanism by which metazoans sense and respond to reductions in local oxygen concentrations. In humans, HIF is critically important for the sustained growth and metastasis of solid tumors. Here, we describe crystal structures of the heterodimer formed by the C-terminal PAS domains from the HIF2{alpha} and ARNT subunits of the HIF2 transcription factor, both in the absence and presence of an artificial ligand. Unexpectedly, the HIF2{alpha} PAS-B domain contains a large internal cavity that accommodates ligands identified from a small-molecule screen. Binding one of these ligands to HIF2{alpha} PAS-B modulates the affinity of the HIF2{alpha}:ARNT PAS-B heterodimer in vitro. Given the essential role of PAS domains in forming active HIF heterodimers, these results suggest a presently uncharacterized ligand-mediated mechanism for regulating HIF2 activity in endogenous and clinical settings.

  11. Parenting Styles and Adjustment in Gifted Children

    ERIC Educational Resources Information Center

    Pilarinos, Vassiliki; Solomon, C. R.

    2017-01-01

    The present study examined the relationship between parenting styles and the psychosocial adjustment of 48 children aged 7 to 11 years, each of whom had been identified as gifted on the basis of a score of 130 or above on the Wechsler Intelligence Scale for Children--Fourth Edition. Parenting styles and child psychosocial adjustment were measured…

  12. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

    NASA Astrophysics Data System (ADS)

    Makino, Yuichi; Cao, Renhai; Svensson, Kristian; Bertilsson, Göran; Asman, Mikael; Tanaka, Hirotoshi; Cao, Yihai; Berkenstam, Anders; Poellinger, Lorenz

    2001-11-01

    Alteration of gene expression is a crucial component of adaptive responses to hypoxia. These responses are mediated by hypoxia-inducible transcription factors (HIFs). Here we describe an inhibitory PAS (Per/Arnt/Sim) domain protein, IPAS, which is a basic helix-loop-helix (bHLH)/PAS protein structurally related to HIFs. IPAS contains no endogenous transactivation function but demonstrates dominant negative regulation of HIF-mediated control of gene expression. Ectopic expression of IPAS in hepatoma cells selectively impairs induction of genes involved in adaptation to a hypoxic environment, notably the vascular endothelial growth factor (VEGF) gene, and results in retarded tumour growth and tumour vascular density in vivo. In mice, IPAS was predominantly expressed in Purkinje cells of the cerebellum and in corneal epithelium of the eye. Expression of IPAS in the cornea correlates with low levels of expression of the VEGF gene under hypoxic conditions. Application of an IPAS antisense oligonucleotide to the mouse cornea induced angiogenesis under normal oxygen conditions, and demonstrated hypoxia-dependent induction of VEGF gene expression in hypoxic corneal cells. These results indicate a previously unknown mechanism for negative regulation of angiogenesis and maintenance of an avascular phenotype.

  13. Sequences that direct subcellular traffic of the Drosophila methoprene-tolerant protein (MET) are located predominantly in the PAS domains.

    PubMed

    Greb-Markiewicz, Beata; Orłowski, Marek; Dobrucki, Jerzy; Ożyhar, Andrzej

    2011-10-15

    Methoprene-tolerant protein (MET) is a key mediator of antimetamorphic signaling in insects. MET belongs to the family of bHLH-PAS transcription factors which regulate gene expression and determine essential physiological and developmental processes. The ability of many bHLH-PAS proteins to carry out their functions is related to the patterns of intracellular trafficking, which are determined by specific sequences and indicate that a nuclear localization signal (NLS) or a nuclear export signal (NES) is present and active. Therefore, the identification of NLS and NES signals is fundamental in order to understand the intracellular signaling role of MET. Nevertheless, data on the intracellular trafficking of MET are inconsistent, and until now there hasn't been any data on potential NLS and NES sequences. To analyze the trafficking of MET we designed a number of expression vectors encoding full-length MET, as well as various derivatives, that were fused to yellow fluorescent protein (YFP). Confocal microscopy analysis of the subcellular distribution of YFP-MET indicated that while this protein was localized mainly in the nucleus, it was also observed in the cytoplasm. This suggested the presence of both an NLS and NES in MET. Our work has shown that each of the two PAS domains of MET (PAS-A and PAS-B, respectively) contain one NLS and one NES sequence. Additional NES activity was present in the C-terminal fragment. The NLS activity located in PAS-B was dependent on the presence of juvenile hormone (JH), the potential ligand for MET. In contrast to this, JH didn't seem to be required for the NLS in PAS-A to be active. However, on the basis of current knowledge about the function of PAS-A in other bHLH-PAS proteins, we suggest there might be other proteins that control the activity of the NLS and possibly the NES located in the PAS-A of MET. Thus, the intracellular trafficking of MET seems to be regulated by a rather complicated network of different factors.

  14. Retaining large and adjustable elastic strains of kilogram-scale Nb nanowires [Better Superconductor by Elastic Strain Engineering: Kilogram-scale Free-Standing Niobium Metal Composite with Large Retained Elastic Strains

    DOE PAGES

    Hao, Shijie; Cui, Lishan; Wang, Hua; ...

    2016-02-10

    Crystals held at ultrahigh elastic strains and stresses may exhibit exceptional physical and chemical properties. Individual metallic nanowires can sustain ultra-large elastic strains of 4-7%. However, retaining elastic strains of such magnitude in kilogram-scale nanowires is challenging. Here, we find that under active load, ~5.6% elastic strain can be achieved in Nb nanowires in a composite material. Moreover, large tensile (2.8%) and compressive (-2.4%) elastic strains can be retained in kilogram-scale Nb nanowires when the composite is unloaded to a free-standing condition. It is then demonstrated that the retained tensile elastic strains of Nb nanowires significantly increase their superconducting transitionmore » temperature and critical magnetic fields, corroborating ab initio calculations based on BCS theory. This free-standing nanocomposite design paradigm opens new avenues for retaining ultra-large elastic strains in great quantities of nanowires and elastic-strain-engineering at industrial scale.« less

  15. Impact of adherence to GOLD guidelines on 6-minute walk distance, MRC dyspnea scale score, lung function decline, quality of life, and quality-adjusted life years in a Shanghai suburb.

    PubMed

    Jiang, Y Q; Zhu, Y X; Chen, X L; Xu, X; Li, F; Fu, H J; Shen, C Y; Lu, Y Y; Zhuang, Q J; Xu, G; Cai, Y Y; Zhang, Y; Liu, S S; Zhu, M Y; Li, S H

    2015-08-03

    We performed a 1-year cluster-randomized field trial to assess the effect of standardized management of chronic obstructive pulmonary disease (COPD) on lung function and quality of life (QOL) measures in patients in China. We used the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines and assessed indexes including pulmonary function, QOL, quality-adjusted life years (QALY), Medical Research Council (MRC) dyspnea scale, 6-min walk distance (6-MWD), number of emergency visits, and frequency of hospitalization. Of a total of 711 patients with chronic cough and asthma, 132 were diagnosed as having COPD and 102 participated in this study [intervention group (N = 47); control group (N = 55)]. We found that adherence to GOLD guidelines had a perceivable impact on 6-MWD, MRC dyspnea scale score, and QOL. The average QALY increased by 1.42/person/year in the intervention group, but declined by 0.95/person/year in the control group. We conclude that standardized management improves disease severity, QOL, and QALY in COPD patients when treatment protocols adhere to GOLD guidelines.

  16. Application of FTIR-PAS and Raman spectroscopies for the determination of organic matter in farmland soils.

    PubMed

    Xing, Zhe; Du, Changwen; Tian, Kang; Ma, Fei; Shen, Yazhen; Zhou, Jianmin

    2016-09-01

    In soil analysis, Raman spectroscopy is not as widely used as infrared spectroscopy mainly owing to fluorescence interferences. This paper investigated the feasibility of Fourier-transform infrared photoacoustic (FTIR-PAS) and Raman spectroscopies for predicting soil organic matter (SOM) using partial least squares regression (PLSR) analysis. 194 farmland soil samples were collected and scanned with FTIR and Raman spectrometers in the spectral range of 4000-400cm(-1) and 180-3200cm(-1), respectively. For the PLSR models, the combined dataset was split into 146 samples as the calibration set (75%) and 48 samples as the validation set (25%). The optimal number of analytical factors was determined using a leave-one-out cross-validation. The results showed that SOM could be predicted using FTIR-PAS and Raman spectroscopies independently, with R(2)>0.70 and RPD>1.8 for the validation sets. In comparison to the single applications of FTIR-PAS and Raman spectroscopies, accurate prediction of SOM was made by combining FTIR-PAS and Raman spectroscopies, with R(2)=0.81 and RPD=2.18 for the validation sets. By statistically assessing large amounts of PLS models, model-population analysis confirmed that the accuracy of the PLS model can be increased by combining FTIR-PAS and Raman spectroscopies. In conclusion, the combination of FTIR-PAS and Raman spectroscopies is a promising alternative for soil characterization, especially for the prediction of SOM, owing to the availability of complementary information from both FTIR-PAS (polar vibrations) and Raman spectroscopy (non-polar vibrations).

  17. Recognition of faux pas by normally developing children and children with Asperger syndrome or high-functioning autism.

    PubMed

    Baron-Cohen, S; O'Riordan, M; Stone, V; Jones, R; Plaisted, K

    1999-10-01

    Most theory of mind (ToM) tests are designed for subjects with a mental age of 4-6 years. There are very few ToM tests for subjects who are older or more able than this. We report a new test of ToM, designed for children 7-11 years old. The task involves recognizing faux pas. Study 1 tested 7-9, and 11-year-old normal children. Results showed that the ability to detect faux pas developed with age and that there was a differential developmental profile between the two sexes (female superiority). Study 2 tested children with Asperger syndrome (AS) or high-functioning autism (HFA), selected for being able to pass traditional 4- to 6-year level (first- and second-order) false belief tests. Results showed that whereas normal 9- to 11-year-old children were skilled at detecting faux pas, children with AS or HFA were impaired on this task. Study 3 reports a refinement in the test, employing control stimuli. This replicated the results from Study 2. Some patients with AS or HFA were able to recognize faux pas but still produced them. Future research should assess faux pas production.

  18. [Evaluation of the website of the Nord-Pas-de-Calais regional pharmacovigilance center].

    PubMed

    Rochoy, Michaël; Béné, Johana; Messaadi, Nassir; Auffret, Marine; Gautier, Sophie

    2016-06-01

    We posted the Nord-Pas-de-Calais regional pharmacovigilance center website and distributed a survey to its potential users between August 2014 and October 2014 (135 general practitioners, 45 pharmacists, 14 patients). Satisfaction was 7.3±1.6 out of 10 points for the visual aspect, 7.8±1.5 out of 10 points for navigation and 7.6±1.4 out of 10 points for content. The website was declared useful by 98% respondents, particularly for the reporting of adverse drugs reactions (89%).

  19. Understanding protected area resilience: a multi-scale, social-ecological approach

    USGS Publications Warehouse

    Cumming, Graeme S.; Allen, Craig R.; Ban, Natalie C.; Biggs, Duan; Biggs, Harry C.; Cumming, David H.M; De Vos, Alta; Epstein, Graham; Etienne, Michel; Maciejewski, Kristine; Mathevet, Raphael; Moore, Christine; Nenadovic, Mateja; Schoon, Michael

    2015-01-01

    Protected areas (PAs) remain central to the conservation of biodiversity. Classical PAs were conceived as areas that would be set aside to maintain a natural state with minimal human influence. However, global environmental change and growing cross-scale anthropogenic influences mean that PAs can no longer be thought of as ecological islands that function independently of the broader social-ecological system in which they are located. For PAs to be resilient (and to contribute to broader social-ecological resilience), they must be able to adapt to changing social and ecological conditions over time in a way that supports the long-term persistence of populations, communities, and ecosystems of conservation concern. We extend Ostrom's social-ecological systems framework to consider the long-term persistence of PAs, as a form of land use embedded in social-ecological systems, with important cross-scale feedbacks. Most notably, we highlight the cross-scale influences and feedbacks on PAs that exist from the local to the global scale, contextualizing PAs within multi-scale social-ecological functional landscapes. Such functional landscapes are integral to understand and manage individual PAs for long-term sustainability. We illustrate our conceptual contribution with three case studies that highlight cross-scale feedbacks and social-ecological interactions in the functioning of PAs and in relation to regional resilience. Our analysis suggests that while ecological, economic, and social processes are often directly relevant to PAs at finer scales, at broader scales, the dominant processes that shape and alter PA resilience are primarily social and economic.

  20. Dos, a heme-binding PAS protein from Escherichia coli, is a direct oxygen sensor.

    PubMed

    Delgado-Nixon, V M; Gonzalez, G; Gilles-Gonzalez, M A

    2000-03-14

    A direct sensor of O(2), the Dos protein, has been found in Escherichia coli. Previously, the only biological sensors known to respond to O(2) by direct and reversible binding were the FixL proteins of Rhizobia. A heme-binding region in Dos is 60% homologous to the O(2)-sensing PAS domain of the FixL protein, but the remainder of Dos does not resemble FixL. Specifically, the C-terminal domain of Dos, presumed to be a regulatory partner that couples to its heme-binding domain, is not a histidine kinase but more closely resembles a phosphodiesterase. The absorption spectra of Dos indicate that both axial positions of the heme iron are coordinated to side chains of the protein. Nevertheless, O(2) and CO bind to Dos with K(d) values of 13 and 10 microM, respectively, indicating a strong discrimination against CO binding. Association rate constants for binding of O(2) (3 mM(-)(1) s(-)(1)), CO (1 mM(-)(1) s(-)(1)) and even NO (2 mM(-)(1) s(-)(1)) are extraordinarily low and very similar. Displacement of an endogenous ligand, probably Met 95, from the heme iron in Dos triggers a conformational change that alters the activity of the enzymatic domain. This sensing mechanism differs from that of FixL but resembles that of the CO sensor CooA of Rhodospirillum rubrum. Overall the results provide evidence for a heme-binding subgroup of PAS-domain proteins whose working range, signaling mechanisms, and regulatory partners can vary considerably.

  1. A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni

    PubMed Central

    Reuter, Mark; Periago, Paula M.; Mulholland, Francis; Brown, Helen L.; van Vliet, Arnoud H. M.

    2015-01-01

    The bipolar flagella of the foodborne bacterial pathogen Campylobacter jejuni confer motility, which is essential for virulence. The flagella of C. jejuni are post-translationally modified, but how this process is controlled is not well understood. In this work, we have identified a novel PAS-domain containing regulatory system, which modulates flagella-flagella interactions in C. jejuni. Inactivation of the cj1387c gene, encoding a YheO-like PAS6 domain linked to a helix-turn-helix domain, resulted in the generation of a tightly associated “cell-train” morphotype, where up to four cells were connected by their flagella. The morphotype was fully motile, resistant to vortexing, accompanied by increased autoagglutination, and was not observed in aflagellated cells. The Δcj1387c mutant displayed increased expression of the adjacent Cj1388 protein, which comprises of a single endoribonuclease L-PSP domain. Comparative genomics showed that cj1387c (yheO) orthologs in bacterial genomes are commonly linked to an adjacent cj1388 ortholog, with some bacteria, including C. jejuni, containing another cj1388-like gene (cj0327). Inactivation of the cj1388 and cj0327 genes resulted in decreased autoagglutination in Tween-20-supplemented media. The Δcj1388 and Δcj0327 mutants were also attenuated in a Galleria larvae-based infection model. Finally, substituting the sole cysteine in Cj1388 for serine prevented Cj1388 dimerization in non-reducing conditions, and resulted in decreased autoagglutination in the presence of Tween-20. We hypothesize that Cj1388 and Cj0327 modulate post-translational modification of the flagella through yet unidentified mechanisms, and propose naming Cj1387 the Campylobacter Flagella Interaction Regulator CfiR, and the Cj1388 and Cj0327 protein as CfiP and CfiQ, respectively. PMID:26284050

  2. Morphological evaluation of canine platelets on Giemsa- and PAS-stained blood smears.

    PubMed

    Halmay, Dóra; Sótonyi, P; Vajdovich, P; Gaál, T

    2005-01-01

    The morphology of canine platelets (changes in size, shape, staining characteristics, degree of activation and clump formation, distribution of granules, appearance of vacuoles on Giemsa-stained smears) was investigated in 20 healthy control and 181 diseased dogs. In the group of the sick dogs 84 animals suffered from disorders affecting directly the haematological parameters or the haematopoietic organs such as bleeding, thymic haemorrhage, haemolytic disorders, lymphoma, immune-mediated thrombocytopenia, and other 97 dogs were affected by other diseases (hepatopathy, nephropathy, hepatic, splenic or intestinal neoplasm, skin diseases, diabetes mellitus, Cushing's syndrome, sepsis). The alterations found in platelet morphology were not specific for any disorder. The most common platelet abnormalities were polychromasia and the presence of giant platelets. These changes occurred in a high number in disorders accompanied by bleeding or haemolysis. Anisocytosis was the most frequent finding in hepatic, splenic or intestinal neoplasms and in certain endocrinopathies. Microcytosis was observed in immune-mediated thrombocytopenia, hepatic neoplasms and endocrine disorders. Extreme platelet activation was common in haemolysis, hepatopathies, neoplastic diseases and sepsis. Vacuolisation was present in thymic haemorrhage, pancreatitis, diabetes mellitus and Cushing's syndrome. A new morphologic phenomenon, i.e. a ring-like formation of granules, was described in the cytoplasm of the platelets both in healthy and diseased animals. In addition, two forms of pathologic granulation were also described for the first time in Giemsa-stained blood smears: the pseudonuclear and the spot-like formation of granules, which were observed especially in disorders affecting the blood cells. The granulation and morphological characteristics of platelets on smears stained by periodic acid-Schiff reaction (PAS) were also studied. Three localisations of granulation were observed, such as

  3. J-PAS and J-PLUS: large sky multi-filter surveys from the Observatorio Astrofisico de Javalambre

    NASA Astrophysics Data System (ADS)

    Cenarro, A. J.; J-PAS Collaboration; J-PLUS Collaboration

    2017-03-01

    During the first years of operation, the Observatorio Astrofísico de Javalambre, in Teruel, is mostly devoted to conduct two large sky multi-filter surveys making use of two telescopes of large field of view, JST/T250 and JAST/T80, and their respective panoramic instrumentation, JPCam and T80Cam. These surveys, managed and developed within a long-term Spanish-Brazilian collaboration of astronomers who cover most fields in Astronomy and Cosmology, are the Javalambre Physics of the Accelerating Universe Astrophysical Survey (J-PAS) and the Javalambre Photometric Local Universe Survey (J-PLUS). J-PAS will observe 8500 deg^2 of the sky visible from Javalambre with a set of 54 narrow-band contiguous optical filters plus 5 broader ones, performing in the end as a low resolution integral field unit for the Northern hemisphere. It will provide unprecedented spectral energy distributions for every pixel of the sky, and ultimately for more than 200 million galaxies and stars. In advance, J-PLUS has started to observe the same sky area of J-PAS with 12 narrow, intermediate and broad-band filters aimed to provide the photometric calibration of J-PAS, and unprecedented multicolor data for many fields of the Astrophysics. Both J-PAS and J-PLUS will provide powerful 3D views of the Universe that will be made publicly available to the community as legacy projects. This proceeding is aimed to present the origin, motivation, characteristics and main scientific goals of the J-PAS and J-PLUS projects as well as the Spanish-Brazilian collaboration making them happen.

  4. Protein Alpha Shape (PAS) Dock: A new gaussian-based score function suitable for docking in homology modelled protein structures

    NASA Astrophysics Data System (ADS)

    Tøndel, Kristin; Anderssen, Endre; Drabløs, Finn

    2006-03-01

    Protein Alpha Shape (PAS) Dock is a new empirical score function suitable for virtual library screening using homology modelled protein structures. Here, the score function is used in combination with the geometry search method Tabu search. A description of the protein binding site is generated using gaussian property fields like in Protein Alpha Shape Similarity Analysis (PASSA). Gaussian property fields are also used to describe the ligand properties. The overlap between the receptor and ligand hydrophilicity and lipophilicity fields is maximised, while minimising steric clashes. Gaussian functions introduce a smoothing of the property fields. This makes the score function robust against small structural variations, and therefore suitable for use with homology models. This also makes it less critical to include protein flexibility in the docking calculations. We use a fast and simplified version of the score function in the geometry search, while a more detailed version is used for the final prediction of the binding free energies. This use of a two-level scoring makes PAS-Dock computationally efficient, and well suited for virtual screening. The PAS-Dock score function is trained on 218 X-ray structures of protein- ligand complexes with experimental binding affinities. The performance of PAS-Dock is compared to two other docking methods, AutoDock and MOE-Dock, with respect to both accuracy and computational efficiency. According to this study, PAS-Dock is more computationally efficient than both AutoDock and MOE-Dock, and gives a better prediction of the free energies of binding. PAS-Dock is also more robust against structural variations than AutoDock.

  5. Loneliness, Self-Concept, and Adjustment.

    ERIC Educational Resources Information Center

    Goswick, Ruth Ann; Jones, Warren H.

    1981-01-01

    In two studies, college students completed the UCLA Loneliness Scale, the Tennessee Self-Concept Scale, and an inventory which assessed the degree of other-focused attention. Results indicated that loneliness was related to more negative self-concepts, possibly less adjustment, and more self-focus. (Author/MP)

  6. Immunosuppressive PAS-1 is an excretory/secretory protein released by larval and adult worms of the ascarid nematode Ascaris suum.

    PubMed

    Antunes, M F P; Titz, T O; Batista, I F C; Marques-Porto, R; Oliveira, C F; Alves de Araujo, C A; Macedo-Soares, M F

    2015-05-01

    Helminths use several strategies to evade and/or modify the host immune response, including suppression or inactivation of the host antigen-specific response. Several helminth immunomodulatory molecules have been identified. Our studies have focused on immunosuppression induced by the roundworm Ascaris suum and an A. suum-derived protein named protein 1 from A. suum (PAS-1). Here we assessed whether PAS-1 is an excretory/secretory (E/S) protein and whether it can suppress lipopolysaccharide-induced inflammation. Larvae from infective eggs were cultured in unsupplemented Dulbecco's modified Eagle medium (DMEM) for 2 weeks. PAS-1 was then measured in the culture supernatants and in adult A. suum body fluid at different time points by enzyme-linked immunosorbent assay (ELISA) with the monoclonal antibody MAIP-1. Secreted PAS-1 was detected in both larval culture supernatant and adult body fluid. It suppressed lipopolysaccharide (LPS)-induced leucocyte migration and pro-inflammatory cytokine production, and stimulated interleukin (IL)-10 secretion, indicating that larval and adult secreted PAS-1 suppresses inflammation in this model. Moreover, the anti-inflammatory activity of PAS-1 was abolished by treatment with MAIP-1, a PAS-1-specific monoclonal antibody, confirming the crucial role of PAS-1 in suppressing LPS-induced inflammation. These findings demonstrate that PAS-1 is an E/S protein with anti-inflammatory properties likely to be attributable to IL-10 production.

  7. Validating a Psychology as a Helping Profession Scale

    ERIC Educational Resources Information Center

    Gervasio, Amy Herstein; Wendorf, Craig A.; Yoder, Natalie F.

    2010-01-01

    We developed an 11-item Psychology as a Helping Profession (PHP) scale that measured aspects of personal growth/helping skills and applied helping. The scale was only weakly correlated with Friedrich's (1996) Psychology as Science (PAS) scale, implying that the 2 scales measure different conceptions of the nature of psychology. Psychology majors…

  8. Biological control of Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) using Aeromonas phage PAS-1.

    PubMed

    Kim, J H; Choresca, C H; Shin, S P; Han, J E; Jun, J W; Park, S C

    2015-02-01

    The potential control efficacy of Aeromonas phage PAS-1 was evaluated against Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) model in this study. The phage was co-cultured with the virulent A. salmonicida subsp. salmonicida strain AS05 that possesses the type III secretion system (TTSS) ascV gene, and efficient bacteriolytic activity was observed against the bacteria. The administration of PAS-1 in rainbow trout demonstrated that the phage was cleared from the fish within 200 h post-administration, and a temporal neutralizing activity against the phage was detected in the sera of phage-administrated fish. The administration of PAS-1 (multiplicity of infection: 10 000) in A. salmonicida subsp. salmonicida infected rainbow trout model showed notable protective effects, with increased survival rates and mean times to death. These results demonstrated that Aeromonas phage PAS-1 could be considered as an alternative biological control agent against A. salmonicida subsp. salmonicida infections in rainbow trout culture.

  9. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... service (CMRS) networks. Under section 706 of the Communications Act, this authority may be superseded by... calls in progress and is to be used during situations when CMRS network congestion is blocking NSEP call... may direct service providers to remove PAS if appropriate. (Note: State and local government...

  10. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Security and Emergency Preparedness (NSEP) B Appendix B to Part 64 Telecommunication FEDERAL COMMUNICATIONS.... 64, App. B Appendix B to Part 64—Priority Access Service (PAS) for National Security and Emergency... service (CMRS) networks. Under section 706 of the Communications Act, this authority may be superseded...

  11. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Security and Emergency Preparedness (NSEP) B Appendix B to Part 64 Telecommunication FEDERAL COMMUNICATIONS.... 64, App. B Appendix B to Part 64—Priority Access Service (PAS) for National Security and Emergency... service (CMRS) networks. Under section 706 of the Communications Act, this authority may be superseded...

  12. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Security and Emergency Preparedness (NSEP) B Appendix B to Part 64 Telecommunication FEDERAL COMMUNICATIONS.... 64, App. B Appendix B to Part 64—Priority Access Service (PAS) for National Security and Emergency... service (CMRS) networks. Under section 706 of the Communications Act, this authority may be superseded...

  13. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Security and Emergency Preparedness (NSEP) B Appendix B to Part 64 Telecommunication FEDERAL COMMUNICATIONS.... 64, App. B Appendix B to Part 64—Priority Access Service (PAS) for National Security and Emergency... service (CMRS) networks. Under section 706 of the Communications Act, this authority may be superseded...

  14. Step-Scan T-Cell Fourier Transform Infrared Photoacoustic Spectroscopy (FTIR-PAS) for Monitoring Environmental Air Pollutants

    NASA Astrophysics Data System (ADS)

    Liu, Lixian; Mandelis, Andreas; Melnikov, Alexander; Michaelian, Kirk; Huan, Huiting; Haisch, Christoph

    2016-07-01

    Air pollutants have adverse effects on the Earth's climate system. There is an urgent need for cost-effective devices capable of recognizing and detecting various ambient pollutants. An FTIR photoacoustic spectroscopy (FTIR-PAS) method based on a commercial FTIR spectrometer developed for air contamination monitoring will be presented. A resonant T-cell was determined to be the most appropriate resonator in view of the low-frequency requirement and space limitations in the sample compartment. Step-scan FTIR-PAS theory for regular cylinder resonator has been described as a reference for prediction of T-cell vibration principles. Both simulated amplitude and phase responses of the T-cell show good agreement with measurement data Carbon dioxide IR absorption spectra were used to demonstrate the capacity of the FTIR-PAS method to detect ambient pollutants. The theoretical detection limit for carbon dioxide was found to be 4 ppmv. A linear response to carbon dioxide concentration was found in the range from 2500 ppmv to 5000 ppmv. The results indicate that it is possible to use step-scan FTIR-PAS with a T-cell as a quantitative method for analysis of ambient contaminants.

  15. Safety evaluation for packaging for the transport of K Basin sludge samples in the PAS-1 cask

    SciTech Connect

    SMITH, R.J.

    1998-11-17

    This safety evaluation for packaging authorizes the shipment of up to two 4-L sludge samples to and from the 325 Lab or 222-S Lab for characterization. The safety of this shipment is based on the current U.S. Department of Energy Certification of Compliance (CoC) for the PAS-1 cask, USA/9184/B(U) (DOE).

  16. The Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD) Checklist: Reliability and Validity of French Version

    ERIC Educational Resources Information Center

    Gerber, F.; Carminati, G. Galli

    2013-01-01

    Background: The lack of psychometric measures of psychopathology especially in intellectual disabilities (ID) population was addressed by creation of the Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD-10) in Moss et?al. This schedule is a structured interview designed for professionals in psychopathology. The…

  17. The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice.

    PubMed

    Tokuda, S; Do Valle, T Z; Batista, L; Simon-Chazottes, D; Guillemot, L; Bouloy, M; Flamand, M; Montagutelli, X; Panthier, J-J

    2015-01-01

    The large variation in individual response to infection with Rift Valley fever virus (RVFV) suggests that host genetic determinants play a role in determining virus-induced disease outcomes. These genetic factors are still unknown. The systemic inoculation of mice with RVFV reproduces major pathological features of severe human disease, notably the hepatitis and encephalitis. A genome scan performed on 546 (BALB/c × MBT) F2 progeny identified three quantitative trait loci (QTLs), denoted Rvfs-1 to Rvfs-3, that were associated with disease susceptibility in MBT/Pas mice. Non-parametric interval-mapping revealed one significant and two suggestive linkages with survival time on chromosomes 2 (Rvfs-1), 5 (Rvfs-3) and 11 (Rvfs-2) with respective logarithm of odds (LOD) scores of 4.58, 2.95 and 2.99. The two-part model, combining survival time and survival/death, identified one significant linkage to Rvfs-2 and one suggestive linkage to Rvfs-1 with respective LOD scores of 5.12 and 4.55. Under a multiple model, with additive effects and sex as a covariate, the three QTLs explained 8.3% of the phenotypic variance. Sex had the strongest influence on susceptibility. The contribution of Rvfs-1, Rvfs-2 and Rvfs-3 to survival time of RVFV-infected mice was further confirmed in congenic mice.

  18. PAS domain containing chemoreceptor couples dynamic changes in metabolism with chemotaxis.

    PubMed

    Xie, Zhihong; Ulrich, Luke E; Zhulin, Igor B; Alexandre, Gladys

    2010-02-02

    Chemoreceptors provide sensory specificity and sensitivity that enable motile bacteria to seek optimal positions for growth and metabolism in gradients of various physicochemical cues. Despite the abundance of chemoreceptors, little is known regarding the sensory specificity and the exact contribution of individual chemoreceptors to the lifestyle of bacteria. Azospirillum brasilense are motile bacteria that can fix atmospheric nitrogen under microaerophilic conditions. Here, we characterized a chemoreceptor in this organism, named AerC, which functions as a redox sensor that enables the cells to seek microaerophilic conditions that support optimum nitrogen fixation. AerC is a representative of a widespread class of soluble chemoreceptors that monitor changes in the redox status of the electron transport system via the FAD cofactor associated with its PAS domains. In A. brasilense, AerC clusters at the cell poles. Its cellular localization and contribution to the behavioral response correlate with its expression pattern and with changes in the overall cellular FAD content under nitrogen-fixing conditions. AerC-mediated energy taxis in A. brasilense prevails under conditions of nitrogen fixation, illustrating a strategy by which cells optimize chemosensing to signaling cues that directly affect current metabolic activities and thus revealing a mechanism by which chemotaxis is coordinated with dynamic changes in cell physiology.

  19. Spondylodiscite granulomateuse: surtout la tuberculose mais ne pas omettre le lymphome

    PubMed Central

    Zinebi, Ali; Rkiouak, Adil; Akhouad, Yousef; Reggad, Ahmed; Kasmy, Zohour; Boudlal, Mostafa; Lho, Abdelhamid Nait; Rabhi, Moncef; Sinaa, Mohamed; Ennibi, Khalid; Chaari, Jilali

    2016-01-01

    Les douleurs lombaires relèvent d'étiologies multiples dont le diagnostic peut être source de grandes difficultés. Le lymphome rachidien primitif est rare et son diagnostic nécessite une biopsie souvent scanoguidée. Un homme de 30 ans, était hospitalisé pour lombalgies inflammatoires évoluant dans un contexte d'altération de l'état général avec à l'examen des douleurs à la palpation des apophyses épineux L2L3, sans syndrome tumoral périphérique. Le bilan biologique montrait un syndrome inflammatoire. Le bilan morphologique était en faveur d'une spondylodiscite. La première biopsie montrait une ostéite granulomateuse. L'aggravation clinique et radiologique sous anti bacillaire a mené à reconsidérer le diagnostic et la deuxième biopsie confirme le diagnostic du lymphome. Le diagnostic de tuberculose osseuse en particulier vertébrale nécessite une confirmation bactériologique et ou histologique pour ne pas méconnaître un lymphome osseux primitif. PMID:28292061

  20. The PAS Domain-Containing Protein HeuR Regulates Heme Uptake in Campylobacter jejuni

    PubMed Central

    Gaddy, Jennifer A.

    2016-01-01

    ABSTRACT Campylobacter jejuni is a leading cause of bacterially derived gastroenteritis. A previous mutant screen demonstrated that the heme uptake system (Chu) is required for full colonization of the chicken gastrointestinal tract. Subsequent work identified a PAS domain-containing regulator, termed HeuR, as being required for chicken colonization. Here we confirm that both the heme uptake system and HeuR are required for full chicken gastrointestinal tract colonization, with the heuR mutant being particularly affected during competition with wild-type C. jejuni. Transcriptomic analysis identified the chu genes—and those encoding other iron uptake systems—as regulatory targets of HeuR. Purified HeuR bound the chuZA promoter region in electrophoretic mobility shift assays. Consistent with a role for HeuR in chu expression, heuR mutants were unable to efficiently use heme as a source of iron under iron-limiting conditions, and mutants exhibited decreased levels of cell-associated iron by mass spectrometry. Finally, we demonstrate that an heuR mutant of C. jejuni is resistant to hydrogen peroxide and that this resistance correlates to elevated levels of catalase activity. These results indicate that HeuR directly and positively regulates iron acquisition from heme and negatively impacts catalase activity by an as yet unidentified mechanism in C. jejuni. PMID:27935836

  1. iPAS: AES Flight System Technology Maturation for Human Spaceflight

    NASA Technical Reports Server (NTRS)

    Othon, William L.

    2014-01-01

    In order to realize the vision of expanding human presence in space, NASA will develop new technologies that can enable future crewed spacecraft to go far beyond Earth orbit. These technologies must be matured to the point that future project managers can accept the risk of incorporating them safely and effectively within integrated spacecraft systems, to satisfy very challenging mission requirements. The technologies must also be applied and managed within an operational context that includes both on-board crew and mission support on Earth. The Advanced Exploration Systems (AES) Program is one part of the NASA strategy to identify and develop key capabilities for human spaceflight, and mature them for future use. To support this initiative, the Integrated Power Avionics and Software (iPAS) environment has been developed that allows engineers, crew, and flight operators to mature promising technologies into applicable capabilities, and to assess the value of these capabilities within a space mission context. This paper describes the development of the integration environment to support technology maturation and risk reduction, and offers examples of technology and mission demonstrations executed to date.

  2. An accurate cluster selection function for the J-PAS narrow-band wide-field survey

    NASA Astrophysics Data System (ADS)

    Ascaso, B.; Benítez, N.; Dupke, R.; Cypriano, E.; Lima-Neto, G.; López-Sanjuan, C.; Varela, J.; Alcaniz, J. S.; Broadhurst, T.; Cenarro, A. J.; Devi, N. Chandrachani; Díaz-García, L. A.; Fernandes, C. A. C.; Hernández-Monteagudo, C.; Mei, S.; Mendes de Oliveira, C.; Molino, A.; Oteo, I.; Schoenell, W.; Sodré, L.; Viironen, K.; Marín-Franch, A.

    2016-03-01

    The impending Javalambre Physics of the accelerating Universe Astrophysical Survey (J-PAS) will be the first wide-field survey of ≳ 8500 deg2 to reach the `stage IV' category. Because of the redshift resolution afforded by 54 narrow-band filters, J-PAS is particularly suitable for cluster detection in the range z<1. The photometric redshift dispersion is estimated to be only ˜0.003 with few outliers ≲4 per cent for galaxies brighter than i ˜ 23 AB, because of the sensitivity of narrow band imaging to absorption and emission lines. Here, we evaluate the cluster selection function for J-PAS using N-body+semi-analytical realistic mock catalogues. We optimally detect clusters from this simulation with the Bayesian Cluster Finder, and we assess the completeness and purity of cluster detection against the mock data. The minimum halo mass threshold we find for detections of galaxy clusters and groups with both >80 per cent completeness and purity is Mh ˜ 5 × 1013 M⊙ up to z ˜ 0.7. We also model the optical observable, M^{*}_CL-halo mass relation, finding a non-evolution with redshift and main scatter of σ _{M^{*}_CL | M_h}˜ 0.14 dex down to a factor 2 lower in mass than other planned broad-band stage IV surveys, at least. For the Mh ˜ 1 × 1014 M⊙ Planck mass limit, J-PAS will arrive up to z ˜ 0.85 with a σ _{M^{*}_CL | M_h}˜ 0.12 dex. Therefore, J-PAS will provide the largest sample of clusters and groups up to z ˜ 0.8 with a mass calibration accuracy comparable to X-ray data.

  3. Remotely Adjustable Hydraulic Pump

    NASA Technical Reports Server (NTRS)

    Kouns, H. H.; Gardner, L. D.

    1987-01-01

    Outlet pressure adjusted to match varying loads. Electrohydraulic servo has positioned sleeve in leftmost position, adjusting outlet pressure to maximum value. Sleeve in equilibrium position, with control land covering control port. For lowest pressure setting, sleeve shifted toward right by increased pressure on sleeve shoulder from servovalve. Pump used in aircraft and robots, where hydraulic actuators repeatedly turned on and off, changing pump load frequently and over wide range.

  4. Adjustable Pitot Probe

    NASA Technical Reports Server (NTRS)

    Ashby, George C., Jr.; Robbins, W. Eugene; Horsley, Lewis A.

    1991-01-01

    Probe readily positionable in core of uniform flow in hypersonic wind tunnel. Formed of pair of mating cylindrical housings: transducer housing and pitot-tube housing. Pitot tube supported by adjustable wedge fairing attached to top of pitot-tube housing with semicircular foot. Probe adjusted both radially and circumferentially. In addition, pressure-sensing transducer cooled internally by water or other cooling fluid passing through annulus of cooling system.

  5. Weighted triangulation adjustment

    USGS Publications Warehouse

    Anderson, Walter L.

    1969-01-01

    The variation of coordinates method is employed to perform a weighted least squares adjustment of horizontal survey networks. Geodetic coordinates are required for each fixed and adjustable station. A preliminary inverse geodetic position computation is made for each observed line. Weights associated with each observed equation for direction, azimuth, and distance are applied in the formation of the normal equations in-the least squares adjustment. The number of normal equations that may be solved is twice the number of new stations and less than 150. When the normal equations are solved, shifts are produced at adjustable stations. Previously computed correction factors are applied to the shifts and a most probable geodetic position is found for each adjustable station. Pinal azimuths and distances are computed. These may be written onto magnetic tape for subsequent computation of state plane or grid coordinates. Input consists of punch cards containing project identification, program options, and position and observation information. Results listed include preliminary and final positions, residuals, observation equations, solution of the normal equations showing magnitudes of shifts, and a plot of each adjusted and fixed station. During processing, data sets containing irrecoverable errors are rejected and the type of error is listed. The computer resumes processing of additional data sets.. Other conditions cause warning-errors to be issued, and processing continues with the current data set.

  6. Prevalence of psychoactive substances in truck drivers in the Nord-Pas-de-Calais region (France).

    PubMed

    Labat, Laurence; Fontaine, Bernard; Delzenne, Chantal; Doublet, Anne; Marek, Marie Christine; Tellier, Dominique; Tonneau, Murielle; Lhermitte, Michel; Frimat, Paul

    2008-01-30

    A previous study conducted in 1995 showed that psychoactive drug use by workers was higher in safety/security workstations than in the rest of the labour force. In order to verify this finding, we conducted a new study in 2003-2004 in the Nord-Pas-de-Calais region, restricted to truck drivers. The aim of this study was to allow harmonizing the professional practice of the occupational physicians, proposing drug prevention and drug testing policies, validating the analytical methods and the guidelines in case of positive testing results. One thousand truck drivers were studied. Urines were tested for amphetamines, cannabinoids, cocaine, opiates, benzodiazepines, buprenorphine and methadone by immunoassay. Urine ethanol determinations were performed by an ADH method. Positive urines for drugs of abuse, methadone or buprenorphine were then tested by gas chromatography or liquid chromatography coupled to mass spectrometry. Out of the 1000 drivers, cannabinoids were detected in 85 cases, opiates in 41 cases, amphetamines in 3 cases and cocaine in only one case. Buprenorphine was detected in 18 cases, methadone in 5 cases and benzodiazepines in 4 cases. Urine ethanol was positive in 50 cases. We found only one case with 6-monoacetylmorphine. Other positive opiates were metabolites of antitussives. The relatively low number of benzodiazepine positive urines could be explained by the lack of sensitivity of the test we used. All these results confirm those of the previous study for cannabinoids and ethanol in safety/security workstations. Positive results for methadone and buprenorphine are eight times higher than in the general population. In conclusion, the authors think that it will be of a great interest to test urine of truck drivers for other classes of psychoactive drugs, using a liquid chromatography-mass spectrometry method.

  7. Recirculating valve lash adjuster

    SciTech Connect

    Stoody, R.R.

    1987-02-24

    This patent describes an internal combustion engine with a valve assembly of the type including overhead valves supported by a cylinder head for opening and closing movements in a substantially vertical direction and a rotatable overhead camshaft thereabove lubricated by engine oil pumped by an engine oil pump. A hydraulic lash adjuster with an internal reservoir therein is solely supplied with run-off lubricating oil from the camshaft which oil is pumped into the internal reservoir of the lash adjuster by self-pumping operation of the lash adjuster produced by lateral forces thereon by the rotative operation of the camshaft comprising: a housing of the lash adjuster including an axially extending bore therethrough with a lower wall means of the housing closing the lower end thereof; a first plunger member being closely slidably received in the bore of the housing and having wall means defining a fluid filled power chamber with the lower wall means of the housing; and a second plunger member of the lash adjuster having a portion being loosely slidably received and extending into the bore of the housing for reciprocation therein. Another portion extends upwardly from the housing to operatively receive alternating side-to-side force inputs from operation of the camshaft.

  8. Dynamic particle accumulation structure (PAS) in half-zone liquid bridge Reconstruction of particle motion by 3-D PTV

    NASA Astrophysics Data System (ADS)

    Ueno, I.; Abe, Y.; Noguchi, K.; Kawamura, H.

    Three-dimensional (3-D) velocity field reconstruction of oscillatory thermocapillary convections in a half-zone liquid bridge with a radius of O (1 mm) was carried out by applying 3-D particle tracking velocimetry (PTV). Simultaneous observation of the particles suspended in the bridge by two CCD cameras was carried out by placing a small cubic beam splitter above a transparent top rod. The reconstruction of the 3-D trajectories and the velocity fields of the particles in the several types of oscillatory-flow regimes were conducted successfully for sufficiently long period without losing particle tracking. With this application the present authors conducted a series of experiments focusing upon the collapse and re-formation process of the PAS by mechanically disturbing fully developed PAS.

  9. Capping risk adjustment?

    PubMed

    Eugster, Patrick; Sennhauser, Michèle; Zweifel, Peter

    2010-07-01

    When premiums are community-rated, risk adjustment (RA) serves to mitigate competitive insurers' incentive to select favorable risks. However, unless fully prospective, it also undermines their incentives for efficiency. By capping its volume, one may try to counteract this tendency, exposing insurers to some financial risk. This in term runs counter the quest to refine the RA formula, which would increase RA volume. Specifically, the adjuster, "Hospitalization or living in a nursing home during the previous year" will be added in Switzerland starting 2012. This paper investigates how to minimize the opportunity cost of capping RA in terms of increased incentives for risk selection.

  10. Television as Textbook: "Cuéntame cómo pasó" in the Spanish (Literature) Classroom

    ERIC Educational Resources Information Center

    Bartlett, Linda; Manyé, Lourdes

    2015-01-01

    The long-running Spanish television program "Cuéntame cómo pasó" represents not only a wildly successful series for Radio Televisión Española, but also an excellent example of the project of historical memory. Premiering in 2001 (but set, in the first season, in 1968), the story of the multigenerational Alcántara family forms a…

  11. Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking

    PubMed Central

    Militi, Stefania; Maywood, Elizabeth S.; Sandate, Colby R.; Chesham, Johanna E.; Parsons, Michael J.; Vibert, Jennifer L.; Joynson, Greg M.; Partch, Carrie L.; Hastings, Michael H.; Nolan, Patrick M.

    2016-01-01

    The suprachiasmatic nucleus (SCN) defines 24 h of time via a transcriptional/posttranslational feedback loop in which transactivation of Per (period) and Cry (cryptochrome) genes by BMAL1–CLOCK complexes is suppressed by PER–CRY complexes. The molecular/structural basis of how circadian protein complexes function is poorly understood. We describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early doors (Edo), in the PER-ARNT-SIM (PAS) domain dimerization region of period 2 (PER2) (I324N) that accelerates the circadian clock of Per2Edo/Edo mice by 1.5 h. Structural and biophysical analyses revealed that Edo alters the packing of the highly conserved interdomain linker of the PER2 PAS core such that, although PER2Edo complexes with clock proteins, its vulnerability to degradation mediated by casein kinase 1ε (CSNK1E) is increased. The functional relevance of this mutation is revealed by the ultrashort (<19 h) but robust circadian rhythms in Per2Edo/Edo; Csnk1eTau/Tau mice and the SCN. These periods are unprecedented in mice. Thus, Per2Edo reveals a direct causal link between the molecular structure of the PER2 PAS core and the pace of SCN circadian timekeeping. PMID:26903623

  12. Psychological Adjustment and Homosexuality.

    ERIC Educational Resources Information Center

    Gonsiorek, John C.

    In this paper, the diverse literature bearing on the topic of homosexuality and psychological adjustment is critically reviewed and synthesized. The first chapter discusses the most crucial methodological issue in this area, the problem of sampling. The kinds of samples used to date are critically examined, and some suggestions for improved…

  13. Self Adjusting Sunglasses

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Corning Glass Works' Serengeti Driver sunglasses are unique in that their lenses self-adjust and filter light while suppressing glare. They eliminate more than 99% of the ultraviolet rays in sunlight. The frames are based on the NASA Anthropometric Source Book.

  14. Self adjusting inclinometer

    DOEpatents

    Hunter, Steven L.

    2002-01-01

    An inclinometer utilizing synchronous demodulation for high resolution and electronic offset adjustment provides a wide dynamic range without any moving components. A device encompassing a tiltmeter and accompanying electronic circuitry provides quasi-leveled tilt sensors that detect highly resolved tilt change without signal saturation.

  15. Low-dose radiation pretreatment improves survival of human ceiling culture-derived proliferative adipocytes (ccdPAs) under hypoxia via HIF-1 alpha and MMP-2 induction

    SciTech Connect

    Adachi, Naoki; Kubota, Yoshitaka; Kosaka, Kentarou; Akita, Shinsuke; Sasahara, Yoshitarou; Kira, Tomoe; Kuroda, Masayuki; Mitsukawa, Nobuyuki; Bujo, Hideaki; Satoh, Kaneshige

    2015-08-07

    Poor survival is a major problem of adipocyte transplantation. We previously reported that VEGF and MMPs secreted from transplanted adipocytes are essential for angiogenesis and adipogenesis. Pretreatment with low-dose (5 Gy) radiation (LDR) increased VEGF, MMP-2, and HIF-1 alpha mRNA expression in human ceiling culture-derived proliferative adipocytes (hccdPAs). Gene expression after LDR differed between adipose-derived stem cells (hASCs) and hccdPAs. Pretreatment with LDR improved the survival of hccdPAs under hypoxia, which is inevitable in the early stages after transplantation. Upregulation of VEGF and MMP-2 after LDR in hccdPAs is mediated by HIF-1 alpha expression. Our results suggest that pretreatment with LDR may improve adipocyte graft survival in a clinical setting through upregulation of VEGF and MMP-2 via HIF-1 alpha. - Highlights: • Ceiling culture-derived proliferative adipocytes (ccdPAs) react to radiation. • Low-dose radiation (LDR) pretreatment improves survival of ccdPAs under hypoxia. • Gene expression after LDR differs between ccdPAs and adipose-derived stem cells. • LDR-induced increase in MMP-2 and VEGF is dependent on HIF-1 alpha induction. • LDR pretreatment may improve the adipocyte graft survival rate in clinical settings.

  16. A Pilot Genome-Scale Profiling of DNA Methylation in Sporadic Pituitary Macroadenomas: Association with Tumor Invasion and Histopathological Subtype

    PubMed Central

    Ling, Chao; Pease, Matthew; Shi, Lingling; Punj, Vasu; Shiroishi, Mark S.; Commins, Deborah; Weisenberger, Daniel J.; Wang, Kai; Zada, Gabriel

    2014-01-01

    Pituitary adenomas (PAs) are neoplasms that may cause a variety of neurological and endocrine effects. Although known causal contributors include heredity, hormonal influence and somatic mutations, the pathophysiologic mechanisms driving tumorigenesis and invasion of sporadic PAs remain unknown. We hypothesized that alterations in DNA methylation are associated with PA invasion and histopathology subtype, and that genome-scale methylation analysis may complement current classification methods for sporadic PAs. Twenty-four surgically-resected sporadic PAs with varying histopathological subtypes were assigned dichotomized Knosp invasion scores and examined using genome-wide DNA methylation profiling and RNA sequencing. PA samples clustered into subgroups according to functional status. Compared with hormonally-active PAs, nonfunctional PAs exhibited global DNA hypermethylation (mean beta-value 0.47 versus 0.42, P = 0.005); the most significant site of differential DNA methylation was within the promoter region of the potassium voltage-gated channel KCNAB2 (FDR = 5.11×10−10). Pathway analysis of promoter-associated CpGs showed that nonfunctional PAs are potentially associated with the ion-channel activity signal pathway. DNA hypermethylation tended to be negatively correlated with gene expression. DNA methylation analysis may be used to identify candidate genes involved in PA function and may potentially complement current standard immunostaining classification in sporadic PAs. DNA hypermethylation of KCNAB2 and downstream ion-channel activity signal pathways may contribute to the endocrine-inactive status of nonfunctional PAs. PMID:24781529

  17. Adjustable Autonomy Testbed

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Schrenkenghost, Debra K.

    2001-01-01

    The Adjustable Autonomy Testbed (AAT) is a simulation-based testbed located in the Intelligent Systems Laboratory in the Automation, Robotics and Simulation Division at NASA Johnson Space Center. The purpose of the testbed is to support evaluation and validation of prototypes of adjustable autonomous agent software for control and fault management for complex systems. The AA T project has developed prototype adjustable autonomous agent software and human interfaces for cooperative fault management. This software builds on current autonomous agent technology by altering the architecture, components and interfaces for effective teamwork between autonomous systems and human experts. Autonomous agents include a planner, flexible executive, low level control and deductive model-based fault isolation. Adjustable autonomy is intended to increase the flexibility and effectiveness of fault management with an autonomous system. The test domain for this work is control of advanced life support systems for habitats for planetary exploration. The CONFIG hybrid discrete event simulation environment provides flexible and dynamically reconfigurable models of the behavior of components and fluids in the life support systems. Both discrete event and continuous (discrete time) simulation are supported, and flows and pressures are computed globally. This provides fast dynamic simulations of interacting hardware systems in closed loops that can be reconfigured during operations scenarios, producing complex cascading effects of operations and failures. Current object-oriented model libraries support modeling of fluid systems, and models have been developed of physico-chemical and biological subsystems for processing advanced life support gases. In FY01, water recovery system models will be developed.

  18. Precision adjustable stage

    DOEpatents

    Cutburth, Ronald W.; Silva, Leonard L.

    1988-01-01

    An improved mounting stage of the type used for the detection of laser beams is disclosed. A stage center block is mounted on each of two opposite sides by a pair of spaced ball bearing tracks which provide stability as well as simplicity. The use of the spaced ball bearing pairs in conjunction with an adjustment screw which also provides support eliminates extraneous stabilization components and permits maximization of the area of the center block laser transmission hole.

  19. Source tracing of fluvial suspended sediments by magnetic and geochemical particle characterization: example of the Canche watershed (Nord-Pas-de-Calais, France)

    NASA Astrophysics Data System (ADS)

    Patault, Edouard; Alary, Claire; Franke, Christine; Gauthier, Arnaud; Abriak, Nor-Edine

    2016-04-01

    In France, erosion by water run-off is estimated to 1.5 t ha-1yr-1 and can exceed 10 t ha-1yr-1 in large growing areas, such as the North of France (Nord-Pas-de-Calais). In this region, the Canche watershed (1294 km2) sustains heavy loss of fertile soils. The land use is mainly dominated by arable lands (80%) and in 2013, 104 kt of suspended sediment transited to the estuary. As demonstrated in literature, agricultural soil erosion leads to the gradual disappearance and depletion of fertile soil, which constitute a non-renewable resource at human time scale. Additionally, water erosion can significantly damage the aquatic habitat and can be responsible for the input of nutrients, bacteria, pesticides, heavy metals and radionuclides into surface waters. Conscious of these effects, many programs have emerged in the Nord-Pas-de-Calais to reduce erosion. This study presents a combination of environmental magnetic proxy parameters and geochemical analyses on sediments and suspended particulate matter. The aim is to develop effective tools to trace erosion by water run-off and quantify this process. In order to identify the respective sediment sources in the Canche watershed, sediment trap samples of suspended particulate matter were recovered at key positions along the Canche watershed. The preliminary results show that magnetic concentration (Mrs) shows typical values for the agricultural soils in the region, but these variations in magnetic concentrations and total irons concentrations are not always correlated, which may be explained by the iron speciation. In calculating the so-called S-ratio for each sample we can distinguish changes in magneto-mineralogy (and thus iron speciation) from magnetite-dominated assemblages in the mainstream Canche (naturel background signal) to high-coercivity-dominated assemblages in the tributaries, typical for soil erosion material rich in hematite/goethite. In combination with the element concentrations from ICP analyses, this proxy

  20. The Mediating Role of Psychological Adjustment between Peer Victimization and Social Adjustment in Adolescence

    PubMed Central

    Romera, Eva M.; Gómez-Ortiz, Olga; Ortega-Ruiz, Rosario

    2016-01-01

    There is extensive scientific evidence of the serious psychological and social effects that peer victimization may have on students, among them internalizing problems such as anxiety or negative self-esteem, difficulties related to low self-efficacy and lower levels of social adjustment. Although a direct relationship has been observed between victimization and these effects, it has not yet been analyzed whether there is a relationship of interdependence between all these measures of psychosocial adjustment. The aim of this study was to examine the relationship between victimization and difficulties related to social adjustment among high school students. To do so, various explanatory models were tested to determine whether psychological adjustment (negative self-esteem, social anxiety and social self-efficacy) could play a mediating role in this relationship, as suggested by other studies on academic adjustment. The sample comprised 2060 Spanish high school students (47.9% girls; mean age = 14.34). The instruments used were the scale of victimization from European Bullying Intervention Project Questionnaire, the negative scale from Rosenberg Self-Esteem Scale, Social Anxiety Scale for Adolescents and a general item about social self-efficacy, all of them self-reports. Structural equation modeling was used to analyze the data. The results confirmed the partial mediating role of negative self-esteem, social anxiety and social self-efficacy between peer victimization and social adjustment and highlight the importance of empowering victimized students to improve their self-esteem and self-efficacy and prevent social anxiety. Such problems lead to the avoidance of social interactions and social reinforcement, thus making it difficult for these students to achieve adequate social adjustment. PMID:27891108

  1. A gigapixel commercially manufactured cryogenic camera for the J-PAS 2.5m survey telescope

    NASA Astrophysics Data System (ADS)

    Jorden, P. R.; Bastable, M.; Clapp, M.; Darby, S.; Dryer, M.; Eaton, T.; Fenemore-Jones, G.; Jerram, P.; Marin-Franch, A.; Palmer, I.; Pittock, R.; Pool, P.; Rennshaw, R.; Taylor, K.; Waltham, N.; Wheeler, P.

    2012-07-01

    The J-PAS (Javalambre Physics-of-the-Accelerating-Universe Astrophysical Survey) project will perform a five-year survey of the northern sky from a new 2.5m telescope in Teruel, Spain. We describe the design concept of a complete cryogenic camera with a mosaic focal plane and 1.2 gigapixel science array which is to be commercially supplied. The focal plane is contained within a novel liquid-nitrogen-cooled vacuum cryostat, with proximity drive electronics designed to achieve a 4 e- readout noise from the 224-channel CCD system.

  2. Adjustable Reeds For Weaving

    NASA Technical Reports Server (NTRS)

    Farley, Gary L.

    1994-01-01

    Local characteristics of fabrics varied to suit special applications. Adjustable reed machinery proposed for use in weaving fabrics in various net shapes, widths, yarn spacings, and yarn angles. Locations of edges of fabric and configuration of warp and filling yarns varied along fabric to obtain specified properties. In machinery, reed wires mounted in groups on sliders, mounted on lengthwise rails in reed frame. Mechanisms incorporated to move sliders lengthwise, parallel to warp yarns, by sliding them along rails; move sliders crosswise by translating reed frame rails perpendicular to warp yarns; and crosswise by spreading reed rails within group. Profile of reed wires in group on each slider changed.

  3. Thermal Weapon Sight (TWS) AN/PAS-13 diffractive optics designed for producibility

    NASA Technical Reports Server (NTRS)

    Anderson, J. Steven; Chen, Chungte W.; Spande, Robert A.

    1993-01-01

    The Thermal Weapon Sight (TWS) program is a manportable 3-5 micrometer forward-looking-infrared (FLIR) rifle sight. The manportable nature requires that the optics modules be lightweight, low cost and compact while maximizing performance. These objectives were met with diffractive optics. TWS promises to be the first FLIR sensor to incorporate kinoform surfaces in full scale production.

  4. Modeling the uptake of neutral organic chemicals on XAD passive air samplers under variable temperatures, external wind speeds and ambient air concentrations (PAS-SIM).

    PubMed

    Armitage, James M; Hayward, Stephen J; Wania, Frank

    2013-01-01

    The main objective of this study was to evaluate the performance and demonstrate the utility of a fugacity-based model of XAD passive air samplers (XAD-PAS) designed to simulate the uptake of neutral organic chemicals under variable temperatures, external wind speeds and ambient air concentrations. The model (PAS-SIM) simulates the transport of the chemical across the air-side boundary layer and within the sampler medium, which is segmented into a user-defined number of thin layers. Model performance was evaluated using data for polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) from a field calibration study (i.e., active and XAD-PAS data) conducted in Egbert, Ontario, Canada. With some exceptions, modeled PAS uptake curves are in good agreement with the empirical PAS data. The results are highly encouraging, given the uncertainty in the active air sampler data used as input and other uncertainties related to model parametrization (e.g., sampler-air partition coefficients, the influence of wind speed on sampling rates). The study supports the further development and evaluation of the PAS-SIM model as a diagnostic (e.g., to aid interpretation of calibration studies and monitoring data) and prognostic (e.g., to inform design of future passive air sampling campaigns) tool.

  5. Continuously adjustable Pulfrich spectacles

    NASA Astrophysics Data System (ADS)

    Jacobs, Ken; Karpf, Ron

    2011-03-01

    A number of Pulfrich 3-D movies and TV shows have been produced, but the standard implementation has inherent drawbacks. The movie and TV industries have correctly concluded that the standard Pulfrich 3-D implementation is not a useful 3-D technique. Continuously Adjustable Pulfrich Spectacles (CAPS) is a new implementation of the Pulfrich effect that allows any scene containing movement in a standard 2-D movie, which are most scenes, to be optionally viewed in 3-D using inexpensive viewing specs. Recent scientific results in the fields of human perception, optoelectronics, video compression and video format conversion are translated into a new implementation of Pulfrich 3- D. CAPS uses these results to continuously adjust to the movie so that the viewing spectacles always conform to the optical density that optimizes the Pulfrich stereoscopic illusion. CAPS instantly provides 3-D immersion to any moving scene in any 2-D movie. Without the glasses, the movie will appear as a normal 2-D image. CAPS work on any viewing device, and with any distribution medium. CAPS is appropriate for viewing Internet streamed movies in 3-D.

  6. Investigations of the structural stability of highly strained [(Al)GaIn]As/Ga (PAs) multiple quantum wells

    NASA Astrophysics Data System (ADS)

    Marschner, T.; Lutgen, S.; Volk, M.; Stolz, W.; Göbel, E. O.

    1996-10-01

    The structural stability of highly strained [(Al)GaIn]As/Ga (PAs) strained layer superlattice (SLS) structures as a function of the average lattice mismatch is investigated. The SLS structures, grown by metalorganic vapor-phase epitaxy, are studied by using high-resolution x-ray diffraction. The range of stable SLS structures obtained experimentally is compared to a recent theoretical model assuming strain relaxation by formation of misfit dislocations [D. C. Houghton, M. Davies, and M. Dion, Appl. Phys. Lett. 64, 505 (1994)]. In particular, the influence of the surface migration length of the group-III species on the growth surface is investigated by varying the Al concentration in the compressively strained [(Al)GaIn]As layers. Structurally stable [(Al)GaIn]As/Ga(PAs) SLS structures having a total layer thickness of 1 μm and an average lattice mismatch of up to (Δd/d)⊥=1.2×10-2 have been realized. These values exceed by far the values of the misfit dislocation model. This behavior indicates that surface morphology changes rather than misfit dislocation formation are the primary cause for the instability of highly strained SLSs.

  7. The Pressure-Activation-Stress scale in relation to ADHD and cortisol.

    PubMed

    Isaksson, J; Nilsson, K W; Lindblad, F

    2015-02-01

    The Pressure-Activation-Stress (PAS) scale is a self-report questionnaire for children concerning perceived stress. To explore behavioral and physiological correlates, we investigated if scores discriminate between a group prone to perceive high levels of stress [children with attention-deficit/hyperactivity disorder (ADHD)] and a healthy school sample, and if they are associated with diurnal cortisol levels. The PAS scale was filled in at home by children (11-17 years) with clinically confirmed ADHD (n = 102) and non-affected comparisons (n = 146). Saliva samples were collected four times during a regular school day for radioimmunoassay analysis of cortisol. Subtypes and severity of ADHD symptoms were determined using parental rating scales. Children with ADHD scored higher on the PAS scale than a school sample. The PAS scores were similar over ages in the ADHD group while they increased with age in the healthy group. Female sex was associated with higher stress in both groups but no gender interaction was found. No association was found between PAS scores and cortisol levels in neither group. Children in the ADHD group had a lower ratio of cortisol levels/perceived stress on all sampling occasions, built up both by the higher PAS scores and the lower cortisol levels in children with ADHD. The higher PAS scores in children with ADHD support the validity of the scale. The lack of association between PAS scores and diurnal cortisol levels is intriguing and illustrates the complexity of the stress concept. Stress-related fragility seems to accompany ADHD during childhood.

  8. The dominant 55 kDa allergen of the subtropical Bahia grass (Paspalum notatum) pollen is a group 13 pollen allergen, Pas n 13.

    PubMed

    Davies, Janet M; Voskamp, Astrid; Dang, Thanh D; Pettit, Benjamin; Loo, Dorothy; Petersen, Arnd; Hill, Michelle M; Upham, John W; Rolland, Jennifer M; O'Hehir, Robyn E

    2011-03-01

    Bahia grass, Paspalum notatum, is an important pollen allergen source with a long season of pollination and wide distribution in subtropical and temperate regions. We aimed to characterize the 55 kDa allergen of Bahia grass pollen (BaGP) and ascertain its clinical importance. BaGP extract was separated by 2D-PAGE and immunoblotted with serum IgE of a grass pollen-allergic patient. The amino-terminal protein sequence of the predominant allergen isoform at 55 kDa had similarity with the group 13 allergens of Timothy grass and maize pollen, Phl p 13 and Zea m 13. Four sequences obtained by rapid amplification of the allergen cDNA ends represented multiple isoforms of Pas n 13. The predicted full length cDNA for Pas n 13 encoded a 423 amino acid glycoprotein including a signal peptide of 28 residues and with a predicted pI of 7.0. Tandem mass spectrometry of tryptic peptides of 2D gel spots identified peptides specific to the deduced amino acid sequence for each of the four Pas n 13 cDNA, representing 47% of the predicted mature protein sequence of Pas n 13. There was 80.6% and 72.6% amino acid identity with Zea m 13 and Phl p 13, respectively. Reactivity with a Phl p 13-specific monoclonal antibody AF6 supported designation of this allergen as Pas n 13. The allergen was purified from BaGP extract by ammonium sulphate precipitation, hydrophobic interaction and size exclusion chromatography. Purified Pas n 13 reacted with serum IgE of 34 of 71 (48%) grass pollen-allergic patients and specifically inhibited IgE reactivity with the 55 kDa band of BaGP for two grass pollen-allergic donors. Four isoforms of Pas n 13 from pI 6.3-7.8 had IgE-reactivity with grass pollen allergic sera. The allergenic activity of purified Pas n 13 was demonstrated by activation of basophils from whole blood of three grass pollen-allergic donors tested but not control donors. Pas n 13 is thus a clinically relevant pollen allergen of the subtropical Bahia grass likely to be important in eliciting

  9. Delay Adjusted Incidence

    Cancer.gov

    This Infographic shows the National Cancer Institute SEER Incidence Trends. The graphs show the Average Annual Percent Change (AAPC) 2002-2011. For Men, Thyroid: 5.3*,Liver & IBD: 3.6*, Melanoma: 2.3*, Kidney: 2.0*, Myeloma: 1.9*, Pancreas: 1.2*, Leukemia: 0.9*, Oral Cavity: 0.5, Non-Hodgkin Lymphoma: 0.3*, Esophagus: -0.1, Brain & ONS: -0.2*, Bladder: -0.6*, All Sites: -1.1*, Stomach: -1.7*, Larynx: -1.9*, Prostate: -2.1*, Lung & Bronchus: -2.4*, and Colon & Rectum: -3/0*. For Women, Thyroid: 5.8*, Liver & IBD: 2.9*, Myeloma: 1.8*, Kidney: 1.6*, Melanoma: 1.5, Corpus & Uterus: 1.3*, Pancreas: 1.1*, Leukemia: 0.6*, Brain & ONS: 0, Non-Hodgkin Lymphoma: -0.1, All Sites: -0.1, Breast: -0.3, Stomach: -0.7*, Oral Cavity: -0.7*, Bladder: -0.9*, Ovary: -0.9*, Lung & Bronchus: -1.0*, Cervix: -2.4*, and Colon & Rectum: -2.7*. * AAPC is significantly different from zero (p<.05). Rates were adjusted for reporting delay in the registry. www.cancer.gov Source: Special section of the Annual Report to the Nation on the Status of Cancer, 1975-2011.

  10. Nonlinear Hydrostatic Adjustment.

    NASA Astrophysics Data System (ADS)

    Bannon, Peter R.

    1996-12-01

    The final equilibrium state of Lamb's hydrostatic adjustment problem is found for finite amplitude heating. Lamb's problem consists of the response of a compressible atmosphere to an instantaneous, horizontally homogeneous heating. Results are presented for both isothermal and nonisothermal atmospheres.As in the linear problem, the fluid displacements are confined to the heated layer and to the region aloft with no displacement of the fluid below the heating. The region above the heating is displaced uniformly upward for heating and downward for cooling. The amplitudes of the displacements are larger for cooling than for warming.Examination of the energetics reveals that the fraction of the heat deposited into the acoustic modes increases linearly with the amplitude of the heating. This fraction is typically small (e.g., 0.06% for a uniform warming of 1 K) and is essentially independent of the lapse rate of the base-state atmosphere. In contrast a fixed fraction of the available energy generated by the heating goes into the acoustic modes. This fraction (e.g., 12% for a standard tropospheric lapse rate) agrees with the linear result and increases with increasing stability of the base-state atmosphere.The compressible results are compared to solutions using various forms of the soundproof equations. None of the soundproof equations predict the finite amplitude solutions accurately. However, in the small amplitude limit, only the equations for deep convection advanced by Dutton and Fichtl predict the thermodynamic state variables accurately for a nonisothermal base-state atmosphere.

  11. Crystal structures of the F and pSLT plasmid TraJ N-terminal regions reveal similar homodimeric PAS folds with functional interchangeability.

    PubMed

    Lu, Jun; Wu, Ruiying; Adkins, Joshua N; Joachimiak, Andrzej; Glover, J N Mark

    2014-09-16

    In the F family of conjugative plasmids, TraJ is an essential transcriptional activator of the tra operon that encodes most of the proteins required for conjugation. Here we report for the first time the X-ray crystal structures of the TraJ N-terminal domains from the prototypic F plasmid (TraJF(11-130)) and from the Salmonella virulence plasmid pSLT (TraJpSLT(1-128)). Both structures contain similar Per-ARNT-Sim (PAS) folds, which further homodimerize through the N-terminal helix and the structurally conserved β-sheet of the PAS fold from each protomer. Mutational analysis reveals that the observed dimeric interface is critical for TraJF transcriptional activation, indicating that dimerization of TraJ is required for its in vivo function. TraJ is specific in activating its cognate tra operon promoter; however, heterologous PAS domains from pSLT and R100 TraJ can functionally replace the TraJF PAS domain, suggesting that the allelic specificity of TraJ is solely mediated by the region C-terminal to the PAS domain.

  12. PAS-MEDIATED DIMERIZATION OF SOLUBLE GUANYLYL CYCLASE REVEALED BY SIGNAL TRANSDUCTION HISTIDINE KINASE DOMAIN CRYSTAL STRUCTURE

    PubMed Central

    Ma, Xiaolei; Sayed, Nazish; Baskaran, Padmamalini; Beuve, Annie; van den Akker, Focco

    2010-01-01

    Signal transduction histidine kinases (STHK) are key for sensing environmental stresses, crucial for cell survival, and attain their sensing ability using small molecule binding domains. The N-terminal domain in an STHK from Nostoc punctiforme is of unknown function yet is homologous to the central region in soluble guanylyl cyclase (sGC), the main receptor for nitric oxide (NO). This domain is termed H-NOXA (or H-NOBA) since it is often associated with the heme-nitric-oxide/oxygen binding (H-NOX) domain. A structure-function approach was taken to investigate the role of H-NOXA in STHK and sGC. We report the 2.1 Å resolution crystal structure of the dimerized H-NOXA domain of STHK, which reveals a Per-Arnt-Sim (PAS) fold. The H-NOXA monomers dimerize in a parallel arrangement juxtaposing their N-terminal helices and preceding residues. Such PAS-dimerization is similar to that previously observed for EcDOS, AvNifL, and RmFixL. Deletion of 7 N-terminal residues affected dimer organization. Alanine scanning mutagenesis in sGC indicates that the H-NOXA domains of sGC could adopt a similar dimer organization. Although most putative interface mutations did decrease sGCβ1 H-NOXA homodimerization, heterodimerization of full length heterodimeric sGC was mostly unaffected likely due to sGC’s additional dimerization contacts in the coiled-coil and catalytic domains. Exceptions are mutations sGC-α1 F285A and -β1 F217A which each caused a drastic drop in NO stimulated activity and mutations sGCα1 Q368A and -β1 Q309A which resulted in both a complete lack of activity and heterodimerization. Our structural and mutational results provide new insights into sGC and STHK dimerization and overall architecture. PMID:18006497

  13. Pathway-specific regulation revisited: cross-regulation of multiple disparate gene clusters by PAS-LuxR transcriptional regulators.

    PubMed

    Vicente, Cláudia M; Payero, Tamara D; Santos-Aberturas, Javier; Barreales, Eva G; de Pedro, Antonio; Aparicio, Jesús F

    2015-06-01

    PAS-LuxR regulators are highly conserved proteins devoted to the control of antifungal production by binding to operators located in given promoters of polyene biosynthetic genes. The canonical operator of PimM, archetype of this class of regulators, has been used here to search for putative targets of orthologous protein PteF in the genome of Streptomyces avermitilis, finding 97 putative operators outside the pentaene filipin gene cluster (pte). The processes putatively affected included genetic information processing; energy, carbohydrate, and lipid metabolism; DNA replication and repair; morphological differentiation; secondary metabolite biosynthesis; and transcriptional regulation, among others. Seventeen of these operators were selected, and their binding to PimM DNA-binding domain was assessed by electrophoretic mobility shift assays. Strikingly, the protein bound all predicted operators suggesting a direct control over targeted processes. As a proof of concept, we studied the biosynthesis of the ATP-synthase inhibitor oligomycin whose gene cluster included two operators. Regulator mutants showed a severe loss of oligomycin production, whereas gene complementation of the mutant restored phenotype, and gene duplication in the wild-type strain boosted oligomycin production. Comparative gene expression analyses in parental and mutant strains by reverse transcription-quantitative polymerase chain reaction of selected olm genes corroborated production results. These results demonstrate that PteF is able to cross-regulate the biosynthesis of two related secondary metabolites, filipin and oligomycin, but might be extended to all the processes indicated above. This study highlights the complexity of the network of interactions in which PAS-LuxR regulators are involved and opens new possibilities for the manipulation of metabolite production in Streptomycetes.

  14. Changes in content of free, conjugated and bound polyamines and osmotic adjustment in adaptation of vetiver grass to water deficit.

    PubMed

    Zhou, Qiang; Yu, Bingjun

    2010-06-01

    Osmotic adjustment and alteration of polyamines (PAs) have been suggested to play roles in plant adaptation to water deficit/drought stress. In this study, the changes in cell intactness, photosynthesis, compatible solutes and PAs [including putrescine (Put), spermidine (Spd) and spermine (Spm) each in free, conjugated and bound forms] were investigated in leaves of vetiver grass exposed to different intensity of water deficit stress and subsequent rewatering. The results showed that, when vetiver grass was exposed to the moderate (20% and 40% PEG-6000 solutions) and severe (60% PEG solution) water deficit for 6days, the plant injury degree (expressed as the parameters of plant growth, cell membrane integrity, water relations and photosynthesis) increased and contents of free and conjugated Put decreased with the rise of PEG concentration. Under the moderate water deficit, the plants could survive by the reduced osmotic potential (psi(s)), increased free and conjugated Spd and Spm in leaves. After subsequent rewatering, the osmotic balance was re-established, most of the above investigated physiological parameters were fully or partly recovered to the control levels. However, it was not the case for the severely-stressed and rewatering plants. It indicates that, vetiver grass can cope well with the moderate water deficit/drought stress by using the strategies of osmotic adjustment and maintenance of total contents of free, conjugated and bound PAs in leaves.

  15. [Interpersonal motivation in a First Year Experience class influences freshmen's university adjustment].

    PubMed

    Nakayama, Rumiko; Nakanishi, Yoshifumi; Nagahama, Fumiyo; Nakajima, Makoto

    2015-06-01

    The present study examined the influence of interpersonal motivation on university adjustment in freshman students enrolled in a First Year Experience (FYE) class. An interpersonal motivation scale and a university adjustment (interpersonal adjustment and academic adjustment) scale were administered twice to 116 FYE students; data from the 88 students who completed both surveys were analyzed. Results from structural equation modeling indicated a causal relationship between interpersonal, motivation and university adjustment: interpersonal adjustment served as a mediator between academic adjustment and interpersonal motivation, the latter of which was assessed using the internalized motivation subscale of the Interpersonal Motivation Scale as well as the Relative Autonomy Index, which measures the autonomy in students' interpersonal attitudes. Thus, revising the FYE class curriculum to include approaches to lowering students' feelings of obligation and/or anxiety in their interpersonal interactions might improve their adjustment to university.

  16. Child adjustment in high conflict families.

    PubMed

    Smith, J; Berthelsen, D; O'Connor, I

    1997-03-01

    Children exposed to spousal violence are at risk for social-emotional problems. This research investigated a number of family and child factors which might influence the effects of witnessing spousal violence on young children. Fifty-four mothers who had at least one child in the age range of 3 to 6 years participated in the study. These women had left a violent relationship 12 to 24 months prior to their participation in the study and were not in a new relationship. Information was collected through a structured interview which included the administration of a standardized family violence measure (conflict tactics scale) and child adjustment profile (child behaviour checklist). Forty-two per cent of the children exhibited a level of behavioural problems which would warrant clinical intervention. The amount of violence that the children witnessed, the children's responses when the violence occurred and whether the child copied the violent partner's behaviour, were associated with the children's behavioural adjustment scores. Maternal parenting style was not found to have a significant effect on behavioural adjustment. The study provided important quantitative and qualitative data on the nature of parent-child relationships and children's adjustment in families where there is spousal violence.

  17. H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein

    PubMed Central

    Valladares, Ricardo B.; Graves, Christina; Wright, Kaitlyn; Gardner, Christopher L.; Lorca, Graciela L.; Gonzalez, Claudio F.

    2015-01-01

    Host and commensals crosstalk, mediated by reactive oxygen species (ROS), has triggered a growing scientific interest to understand the mechanisms governing such interaction. However, the majority of the scientific studies published do not evaluate the ROS production by commensals bacteria. In this context we recently showed that Lactobacillus johnsonii N6.2, a strain of probiotic value, modulates the activity of the critical enzymes 2,3-indoleamine dioxygenase via H2O2 production. L. johnsonii N6.2 by decreasing IDO activity, is able to modify the tryptophan/kynurenine ratio in the host blood with further systemic consequences. Understanding the mechanisms of H2O2 production is critical to predict the probiotic value of these strains and to optimize bacterial biomass production in industrial processes. We performed a transcriptome analysis to identify genes differentially expressed in L. johnsonii N6.2 cells collected from cultures grown under different aeration conditions. Herein we described the biochemical characteristics of a heterodimeric FMN reductase (FRedA/B) whose in vitro activity is controlled by LjPAS protein with a typical Per-Arnst-Sim (PAS) sensor domain. Interestingly, LjPAS is fused to the FMN reductase domains in other lactobacillaceae. In L. johnsonii, LjPAS is encoded by an independent gene which expression is repressed under anaerobic conditions (>3 fold). Purified LjPAS was able to slow down the FRedA/B initial activity rate when the holoenzyme precursors (FredA, FredB, and FMN) were mixed in vitro. Altogether the results obtained suggest that LjPAS module regulates the H2O2 production helping the cells to minimize oxidative stress in response to environmental conditions. PMID:26236298

  18. Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation

    PubMed Central

    Corrada, Dario; Soshilov, Anatoly A.; Denison, Michael S.

    2016-01-01

    The Aryl hydrocarbon Receptor (AhR) is a transcription factor that mediates the biochemical response to xenobiotics and the toxic effects of a number of environmental contaminants, including dioxins. Recently, endogenous regulatory roles for the AhR in normal physiology and development have also been reported, thus extending the interest in understanding its molecular mechanisms of activation. Since dimerization with the AhR Nuclear Translocator (ARNT) protein, occurring through the Helix-Loop-Helix (HLH) and PER-ARNT-SIM (PAS) domains, is needed to convert the AhR into its transcriptionally active form, deciphering the AhR:ARNT dimerization mode would provide insights into the mechanisms of AhR transformation. Here we present homology models of the murine AhR:ARNT PAS domain dimer developed using recently available X-ray structures of other bHLH-PAS protein dimers. Due to the different reciprocal orientation and interaction surfaces in the different template dimers, two alternative models were developed for both the PAS-A and PAS-B dimers and they were characterized by combining a number of computational evaluations. Both well-established hot spot prediction methods and new approaches to analyze individual residue and residue-pairwise contributions to the MM-GBSA binding free energies were adopted to predict residues critical for dimer stabilization. On this basis, a mutagenesis strategy for both the murine AhR and ARNT proteins was designed and ligand-dependent DNA binding ability of the AhR:ARNT heterodimer mutants was evaluated. While functional analysis disfavored the HIF2α:ARNT heterodimer-based PAS-B model, most mutants derived from the CLOCK:BMAL1-based AhR:ARNT dimer models of both the PAS-A and the PAS-B dramatically decreased the levels of DNA binding, suggesting this latter model as the most suitable for describing AhR:ARNT dimerization. These novel results open new research directions focused at elucidating basic molecular mechanisms underlying the

  19. Spousal Adjustment to Myocardial Infarction.

    ERIC Educational Resources Information Center

    Ziglar, Elisa J.

    This paper reviews the literature on the stresses and coping strategies of spouses of patients with myocardial infarction (MI). It attempts to identify specific problem areas of adjustment for the spouse and to explore the effects of spousal adjustment on patient recovery. Chapter one provides an overview of the importance in examining the…

  20. Molecular phylogenomic study and the role of exogenous spermidine in the metabolic adjustment of endogenous polyamine in two rice cultivars under salt stress.

    PubMed

    Saha, Jayita; Giri, Kalyan

    2017-04-20

    Compelling evidences anticipated the well acclamation of involvement of exogenous and endogenous polyamines (PAs) in conferring salt tolerance in plants. Intracellular PA's anabolism and catabolism should have contributed to maintain endogenous PAs homeostasis to induce stress signal networks. In this report, the evolutionary study has been conducted to reveal the phylogenetic relationship of genes encoding enzymes of the anabolic and catabolic pathway of PAs among the five plant lineages including green algae, moss, lycophyte, dicot and monocot along with their respective exon-intron structural patterns. Our results indicated that natural selection pressure had considerable influence on the ancestral PA metabolic pathway coding genes of land plants. PA metabolic genes have undergone gradual evolution by duplication and diversification process leading to subsequent structural modification through exon-intron gain and loss events to acquire specific function under environmental stress conditions. We have illuminated on the potential regulation of both the pathways by investigating the real-time expression analyses of PA metabolic pathway related enzyme coding genes at the transcriptional level in root and shoot tissues of two indica rice varieties, namely IR 36 (salt sensitive) and Nonabokra (salt-tolerant) in response to salinity in presence or absence of exogenous spermidine (Spd) treatment. Additionally, we have performed tissue specific quantification of the intracellular PAs and tried to draw probable connection between the PA metabolic pathway activation and endogenous PAs accumulation. Our results successfully enlighten the fact that how exogenous Spd in presence or absence of salt stress adjust the intracellular PA pathways to equilibrate the cellular PAs that would have been attributed to plant salt tolerance.

  1. Nonlinear Theory of The Geostrophic Adjustment

    NASA Astrophysics Data System (ADS)

    Zeitlin, V.

    Nonlinear geostrophic adjustment and splitting of the fast and slow dynamical vari- ables are analysed in the framework of multi-layer and continuously stratified prim- itive equations by means of the multi-scale perturbation theory in the Rossby num- ber applied to localized initial disturbances. Two basic dynamical regimes: the quasi- geostrophic (QG) and the frontal geostrophic (FG) with small and large deviations of the isopycnal surfaces, respectively, are considered and differences in corresponding adjustment scenarios are displayed. Decoupling of the fast component of the flow is proven up to the third order in Rossby number and long-time corrections to the stan- dard balanced QG and FG models are found. Peculiarities of splitting in the FG regime due to the quasi-inertial oscillations are displayed and a Schrodinger-like modulation equations for the envelope of these latter are derived.

  2. Modeling the Arabidopsis seed shape by a cardioid: efficacy of the adjustment with a scale change with factor equal to the Golden Ratio and analysis of seed shape in ethylene mutants.

    PubMed

    Cervantes, Emilio; Javier Martín, José; Ardanuy, Ramón; de Diego, Juana G; Tocino, Angel

    2010-03-15

    A new model for the description of Arabidopsis seed shape based on the comparison of the outline of its longitudinal section with a transformed cardioid is presented. The transformation consists of scaling the horizontal axis by a factor equal to the Golden Ratio. The elongated cardioid approximates the shape of the Arabidopsis seed with more accuracy than other figures. The length to width ratio in wild-type Columbia Arabidopsis dry seeds is close to the Golden Ratio and decreases over the course of imbibition. Dry seeds of etr1-1 mutants presented a reduced length to width ratio. Application of the new model based on the cardioid allows for comparison of shape between wild-type and mutant genotypes, revealing other general alterations in the seeds in ethylene signaling pathway mutants (etr1-1).

  3. Psychometric Evaluation of a Dutch Version of the Mini PAS-ADD for Assessing Psychiatric Disorders in Adults with Different Levels of Intellectual Disability

    ERIC Educational Resources Information Center

    Janssen, R.; Maes, B.

    2013-01-01

    Background: People with intellectual disabilities (ID) have an increased vulnerability to develop psychiatric problems. Moreover, the early recognition and the accurate diagnosis of psychiatric disorders in the population of persons with ID are challenging. Method: A Dutch version of the Mini PAS-ADD, which is a screening instrument for…

  4. Crystal structures of the F and pSLT plasmid TraJ N-terminal regions reveal similar homodimeric PAS folds with functional interchangeability

    SciTech Connect

    Lu, Jun; Wu, Ruiying; Adkins, Joshua N.; Joachimiak, Andrzej; Glover, Mark

    2014-09-16

    In the F-family of conjugative plasmids, TraJ is an essential transcriptional activator of the tra operon that encodes most of the proteins required for conjugation. Here we report for the first time the X-ray crystal structures of the TraJ N-terminal regions from the prototypic F plasmid (TraJF11-130) and from the Salmonella virulence plasmid pSLT (TraJpSLT 1-128). Both proteins form similar homodimeric Per-ARNT-Sim (PAS) fold structures. Mutational analysis reveals that the observed dimeric interface is critical for TraJF transcriptional activation, indicating that dimerization of TraJ is required for its in vivo function. An artificial ligand (oxidized dithiothreitol) occupies a cavity in the TraJF dimer interface, while a smaller cavity in corresponding region of the TraJpSLT structure lacks a ligand. Gas chromatography/mass spectrometry-electron ionization analysis of dithiothreitol-free TraJF suggests indole may be the natural TraJ ligand; however, disruption of the indole biosynthetic pathway does not affect TraJF function. Heterologous PAS domains from pSLT and R100 TraJ can functionally replace the TraJF PAS domain, suggesting that TraJ allelic specificity is mediated by the region C-terminal to the PAS domain.

  5. Step-scan T cell-based differential Fourier transform infrared photoacoustic spectroscopy (DFTIR-PAS) for detection of ambient air contaminants

    NASA Astrophysics Data System (ADS)

    Liu, Lixian; Mandelis, Andreas; Huan, Huiting; Melnikov, Alexander

    2016-10-01

    A step-scan differential Fourier transform infrared photoacoustic spectroscopy (DFTIR-PAS) using a commercial FTIR spectrometer was developed theoretically and experimentally for air contaminant monitoring. The configuration comprises two identical, small-size and low-resonance-frequency T cells satisfying the conflicting requirements of low chopping frequency and limited space in the sample compartment. Carbon dioxide (CO2) IR absorption spectra were used to demonstrate the capability of the DFTIR-PAS method to detect ambient pollutants. A linear amplitude response to CO2 concentrations from 100 to 10,000 ppmv was observed, leading to a theoretical detection limit of 2 ppmv. The differential mode was able to suppress the coherent noise, thereby imparting the DFTIR-PAS method with a better signal-to-noise ratio and lower theoretical detection limit than the single mode. The results indicate that it is possible to use step-scan DFTIR-PAS with T cells as a quantitative method for high sensitivity analysis of ambient contaminants.

  6. Extinction, seeing and sky transparency monitoring at the Observatorio Astrofísico de Javalambre for J-PAS and J-PLUS calibration and scheduling

    NASA Astrophysics Data System (ADS)

    Vázquez Ramió, H.; Díaz-Martín, M. C.; Varela, J.; Ederoclite, A.; Maícas, N. Lamadrid, J. L.; Abril, J.; Iglesias-Marzoa, R.; Rodríguez, S.; Tilve, V.; Cenarro, A. J.; Antón Bravo, J. L.; Bello Ferrer, R.; Cristóbal-Hornillos, D.; Guillén Civera, L.; Hernández-Fuertes, J.; Jiménez Mejías, D.; Lasso-Cabrera, N. M.; López Alegre, G.; López Sainz, A.; Luis-Simoes, R. M.; Marín-Franch, A.; Moles, M.; Rueda-Teruel, F.; Rueda-Teruel, S.; Suárez López, O.; Yanes-Díaz, A.

    2015-05-01

    The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS; see Benítez et al. 2014) and the Javalambre-Photometric Local Universe Survey (J-PLUS) will be conducted at the brand-new Observatorio Astrofísico de Javalambre (OAJ) in Teruel, Spain. J-PLUS is planned to start by the first half of 2015 while J-PAS first light is expected to happen along 2015. Besides the two main telescopes (with 2.5 m and 80 cm apertures), several smaller-sized facilities are present at the OAJ devoted to site characterization and supporting measurements to be used to calibrate the J-PAS and J-PLUS photometry and to feed up the OAJ's Sequencer with the integrated seeing and the sky transparency. These instruments are: i) an extinction monitor, an 11 " telescope estimating the atmospheric extinction to finally obtain the OAJ extinction curve, which is the initial step to J-PAS overall photometric calibration procedure; ii) an 8 " telescope implementing the Differential Image Motion Monitor (DIMM) technique to obtain the integrated seeing; and iii) an All-Sky Transmission MONitor (ASTMON), a roughly all-sky instrument providing the sky transparency as well as sky brightness and the atmospheric extinction too.

  7. FTIR-PAS: a powerful tool for characterising the chemical composition and predicting the labile C fraction of various organic waste products.

    PubMed

    Bekiaris, Georgios; Bruun, Sander; Peltre, Clément; Houot, Sabine; Jensen, Lars S

    2015-05-01

    Fourier transform infrared (FT-IR) spectroscopy has been used for several years as a fast, low-cost, reliable technique for characterising a large variety of materials. However, the strong influence of sample particle size and the inability to measure the absorption of very dark and opaque samples have made FTIR unsuitable for many waste materials. FTIR-photoacoustic spectroscopy (FTIR-PAS) can eliminate some of the shortcomings of traditional FTIR caused by scattering effects and reflection issues, and recent advances in PAS technology have made commercial instruments available. In this study, FTIR-PAS was used to characterise a wide range of organic waste products and predict their labile carbon fraction, which is normally determined from time-consuming assays. FTIR-PAS was found to be capable of predicting the labile fraction of carbon as efficiently as near infrared spectroscopy (NIR) and furthermore of identifying the compounds that are correlated with the predicted parameter, thus facilitating a more mechanistic interpretation.

  8. Variation in Venoms of Polybia Paulista Von Ihering and Polybia Occidentalis Olivier (Hymenoptera: Vespidae), Assessed by the FTIR-PAS Technique.

    PubMed

    Mendonça, A; Paula, M C; Fernandes, W D; Andrade, L H C; Lima, S M; Antonialli-Junior, W F

    2017-02-01

    Wasps are able to synthesize toxic compounds known as venoms, which form a part of a mechanism to overcome prey and also to defend their colonies. Study of the compounds that constitute these substances is essential in order to understand how this defense mechanism evolved, since there is evidence that the venoms can vary both intra- and interspecifically. Some studies have used liquid and gas chromatography as a reliable technique to analyze these compounds. However, the use of Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS) to analyze the variations in venom's chemical profile has been proposed recently. This study evaluated whether the FTIR-PAS technique is effective for assessing the role of environmental factors on intra- and interspecific differences in the venom of the wasps Polybia paulista Von Ihering and Polybia occidentalis Olivier by FTIR-PAS. The colonies were collected in three municipalities of Mato Grosso do Sul, Brazil, in different types of environments. The results showed that the venoms of P. paulista and P. occidentalis differed significantly in profile. In addition, the intraspecific differences in the venom's chemical profile of P. paulista are related to the type of environment where they nested, regardless of the geographical distance between the nests. The FTIR-PAS technique proved to be reliable and effective to evaluate the variations in the venom's chemical profile in social wasps.

  9. Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2/9 Mediated through ERK1/2 and p38

    PubMed Central

    Chang, Yung-Ming; Shih, Ying-Ting; Chen, Yueh-Sheng; Liu, Chien-Liang; Fang, Wen-Kuei; Tsai, Chang-Hai; Tsai, Fuu-Jen; Kuo, Wei-Wen; Lai, Tung-Yuan; Huang, Chih-Yang

    2011-01-01

    The earthworm, which has stasis removal and wound-healing functions, is a widely used Chinese herbal medicine in China. Schwann cell migration is critical for the regeneration of injured nerves. Schwann cells provide an essentially supportive activity for neuron regeneration. However, the molecular migration mechanisms induced by earthworms in Schwann cells remain unclear. Here, we investigate the roles of MAPK (ERK1/2, JNK and p38) pathways for earthworm-induced matrix-degrading proteolytic enzyme (PAs and MMP2/9) production in Schwann cells. Moreover, earthworm induced phosphorylation of ERK1/2 and p38, but not JNK, activate the downstream signaling expression of PAs and MMPs in a time-dependent manner. Earthworm-stimulated ERK1/2 and p38 phosphorylation was attenuated by pretreatment with U0126 and SB203580, resulting in migration and uPA-related signal pathway inhibition. The results were confirmed using small interfering ERK1/2 and p38 RNA. These results demonstrated that earthworms can stimulate Schwann cell migration and up-regulate PAs and MMP2/9 expression mediated through the MAPK pathways, ERK1/2 and p38. Taken together, our data suggests the MAPKs (ERK1/2, p38)-, PAs (uPA, tPA)-, MMP (MMP2, MMP9) signaling pathway of Schwann cells regulated by earthworms might play a major role in Schwann cell migration and nerve regeneration. PMID:19808845

  10. Cascaded solar photovoltaic cells based on InP-GaInPAs and InP-CdS heterostructures

    SciTech Connect

    Allakhverdiyev, A.M.; Andreyev, V.; Guseynov, I.A.; Iventyeva, O.O.; Ismailov, V.I.

    1984-08-01

    Cascaded solar cells with different widths of the forbidden band narrow band and wide band were studied. The narrow band cell was based on nInP-n(p)GaInPAs-pInP structure, and the wide band cell was based on pInP-nCdS heterostructure with similar lattice parameters of the contacting materials. The narrow band cells were made by liquid phase epitaxy, and the wide band cells were made by gas transport precipitation of CdS. The spectral characteristics show the feasibility of expanding the region of photosensitivity by using the principle of cascaded conversion of solar energy. The cell with pn junction in Ga0.5In0.75As0.85P0.42 utilizes light with photon energies of less than 1.35 eV that have passed without absorption through the covering photocell. The longwave limits of photosensitivity are determined by the width of the forbidden band of the active region of the corresponding photocells. The shortwave end of the spectrum is stretched out as a result of the low surface recombination rate.

  11. Cascaded solar photovoltaic cells based on InP-GaInPAs and InP-CdS heterostructures

    NASA Astrophysics Data System (ADS)

    Allakhverdiyev, A. M.; Andreyev, V.; Guseynov, I. A.; Iventyeva, O. O.; Ismailov, V. I.

    1984-08-01

    Cascaded solar cells with different widths of the forbidden band narrow band and wide band was studied. The narrow band cell was based on nInP-n(p)GaInPAs-pInP structure, and the wide band cell was based on pInP-nCdS heterostructure with similar lattice parameters of the contacting materials. The narrow band cells were made by liquid phase epitaxy, and the wide band cells were made by gas transport precipitation of CdS. The spectral characteristics show the feasibility of expanding the region of photosensitivity by using the principle of cascaded conversion of solar energy. The cell with pn junction in Ga0.5In0.75As0.85P0.42 utilizes light with photon energies of less than 1.35 eV that have passed without absorption through the covering photocell. The longwave limits of photosensitivity are determined by the width of the forbidden band of the active region of the corresponding photocells. The shortwave end of the spectrum is stretched out as a result of the low surface recombination rate.

  12. Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning.

    PubMed

    March, Amelia; Borchelt, David; Golde, Todd; Janus, Christopher

    2014-02-01

    Fear-conditioning testing paradigms have been used to study differences in memory formation between inbred mouse strains, including numerous mouse models of human diseases. In this study, we characterized the conditioned fear memory of 3 inbred strains: C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl, obtained from Charles River Laboratories. We used 2 training paradigms: delay conditioning, in which an unconditional stimulus coterminates with the presentation of a conditional stimulus, and trace conditioning, in which the conditional and unconditional stimuli are separated by a trace interval. In each paradigm, we evaluated the recent (3 d) and remote (25 d) memory of the mice by using a longitudinal design. Our results showed that both C57BL/6NCrl and 129S2/SvPasCrl mice developed strong and long-lasting context and tone memories in both paradigms, but FVB/NCrl mice showed a weaker but nevertheless consistent tone memory after delay training. Tone memory in the FVB strain was stronger in male than female mice. The remote tone memory of 129S2/SvPasCrl mice diminished after delay training but was stable and stronger than that of C57BL/6NCrl mice after trace training. In conclusion, both C57BL/6NCrl and 129S2/SvPasCrl mice showed reliable and long-lasting fear memory after delay or trace training, with 129 mice showing particularly strong tone memory after trace conditioning. The FVB/NCrl strain, especially male mice, showed reliable tone fear memory after delay training. Our findings confirm that both C57BL/6NCrl and 129S2/SvPasCrl mice develop strong context and tone memory in delay and trace fear-conditioning paradigms.

  13. Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay.

    PubMed

    Valerio, Lorenzo; Consolo, Filippo; Bluestein, Danny; Tran, Phat; Slepian, Marvin; Redaelli, Alberto; Pappalardo, Federico

    2015-08-01

    Left ventricular assist devices (LVADs) have emerged as vital life-saving therapeutic systems for patients with advanced and end-stage heart failure (HF). Despite their efficacy, VAD systems remain limited by post-implantation thrombotic complications. Shear-mediated platelet activation is the major driver of such complications in these devices. Nowadays few platelet function assays are routinely utilized in assessing the degree of platelet activation in VAD implanted patients. No assays exist that specifically target shear-mediated platelet activation. The platelet activity state (PAS) is a novel assay that has been well validated in vitro, measuring thrombin release as a surrogate for shear-mediated platelet activation. To date limited data exist as to the utility of this assay in the clinical setting. In the present study we evaluated eight LVAD patients' platelet activation level using the PAS assay. Simultaneous measurements of conventional prothrombotic and hemolysis markers, - i.e. fibrinogen and lactate dehydrogenase (LDH) - were also performed. Trends as to alteration from baseline were studied. We observed that the PAS assay allowed detection of an abnormal level of platelet activation in one patient in our series who suffered from an overt thrombosis. Interestingly in the same patient no signal of major abnormality in fibrinogen or LDH was detected. Further for 7/8 patients who were free of thrombosis, no significant level of platelet activation was detected via PAS assay, while elevation in fibrinogen and LDH were observed. As such, from our observational series it appears that the PAS assay is a sensitive and specific indicator of shear-mediated platelet activation. Further patients' experience will help elucidate the role of this promising assay in the management of LVAD implanted patients.

  14. Adjustable Induction-Heating Coil

    NASA Technical Reports Server (NTRS)

    Ellis, Rod; Bartolotta, Paul

    1990-01-01

    Improved design for induction-heating work coil facilitates optimization of heating in different metal specimens. Three segments adjusted independently to obtain desired distribution of temperature. Reduces time needed to achieve required temperature profiles.

  15. Preschool Children's School Adjustment: Indicators of Behaviour Problems, Gender, and Peer Victimisation

    ERIC Educational Resources Information Center

    Yoleri, Sibel

    2015-01-01

    The relationships among school adjustment, victimisation, and gender were investigated with 284 Turkish children aged between five and six years. Teacher Rating Scale of School Adjustment, The Preschool Behaviour Questionnaire, and Peer Victimisation Scale were used in this study. Analyses indicated that children's behaviour problems and…

  16. Hardware and software facilities for the J-PAS and J-PLUS surveys archiving, processing and data publication

    NASA Astrophysics Data System (ADS)

    Cristóbal-Hornillos, D.; Varela, J.; Ederoclite, A.; Vázquez Ramió, H.; López-Sainz, A.; Hernández-Fuertes, J.; Civera, T.; Muniesa, D.; Moles, M.; Cenarro, A. J.; Marín-Franch, A.; Yanes-Díaz, A.

    2015-05-01

    The Observatorio Astrofísico de Javalambre consists of two main telescopes: JST/T250, a 2.5 m telescope with a FoV of 3 deg, and JAST/T80, a 83 cm with a 2 deg FoV. JST/T250 will be devoted to complete the Javalambre-PAU Astronomical Survey (J-PAS). It is a photometric survey with a system of 54 narrow-band plus 3 broad-band filters covering an area of 8500°^2. The JAST/T80 will perform the J-PLUS survey, covering the same area in a system of 12 filters. This contribution presents the software and hardware architecture designed to store and process the data. The processing pipeline runs daily and it is devoted to correct instrumental signature on the science images, to perform astrometric and photometric calibration, and the computation of individual image catalogs. In a second stage, the pipeline performs the combination of the tile mosaics and the computation of final catalogs. The catalogs are ingested in as Scientific database to be provided to the community. The processing software is connected with a management database to store persistent information about the pipeline operations done on each frame. The processing pipeline is executed in a computing cluster under a batch queuing system. Regarding the storage system, it will combine disk and tape technologies. The disk storage system will have capacity to store the data that is accessed by the pipeline. The tape library will store and archive the raw data and earlier data releases with lower access frequency.

  17. The role of anticipatory postural adjustments in interlimb coordination of coupled arm movements in the parasagittal plane: II. Postural activities and coupling coordination during cyclic flexion-extension arm movements, ISO- and ANTI-directionally coupled.

    PubMed

    Baldissera, Fausto G; Esposti, Roberto

    2013-08-01

    When coupling cyclic adduction-abduction movements of the arms in the transverse (horizontal) plane, isodirectional (ISO) coupling is less stable than antidirectional (ANTI) coupling. We proposed that such deficiency stems from the disturbing action that anticipatory postural adjustments exert on ISO coupling. To ascertain if postural adjustments differentiate ISO versus ANTI coupling coordination in other types of cyclic arm movements, we examined flexion-extension oscillations in the parasagittal plane. Oscillations of the right arm alone elicited cyclic Postural Adjustments (PAs) in the left Anterior Deltoid and Posterior Deltoid, which replicated the excitation-inhibition pattern of the prime movers right Anterior Deltoid, right Posterior Deltoid. Cyclic PAs also developed symmetrically in Erector Spinae (RES and LES) and in phase opposition in Ischiocruralis (RIC and LIC), so as to discharge to the ground both an anteroposterior force, Fy, and a moment about the vertical axis, Tz. Oscillations of both arms in ISO coupling induced symmetric PAs in both ES and IC muscles, thus generating a large Fy but no Tz. In ANTI coupling, PAs in RES and LES remained symmetric but smaller in size, while PAs in RIC and LIC were large and opposite in phase, resulting in a large Tz and small Fy. Altogether, PAs would thus favour ISO and hamper ANTI parasagittal movements because (1) in the motor pathways to the prime movers of either arm, a convergence would occur between the voluntary commands and the commands for PAs linked to the movement of the other arm, the two commands having the same sign (excitatory or inhibitory) during ISO and an opposite sign during ANTI; (2) the postural effort of trunk and leg muscles would be higher for generating Tz in ANTI than Fy in ISO. These predictions fit with the finding that coupling stability was lower in ANTI than in ISO, i.e., opposite to horizontal movements. In conclusion, in both parasagittal and horizontal arm movements, the less

  18. Adjusting to Chronic Health Conditions.

    PubMed

    Helgeson, Vicki S; Zajdel, Melissa

    2017-01-03

    Research on adjustment to chronic disease is critical in today's world, in which people are living longer lives, but lives are increasingly likely to be characterized by one or more chronic illnesses. Chronic illnesses may deteriorate, enter remission, or fluctuate, but their defining characteristic is that they persist. In this review, we first examine the effects of chronic disease on one's sense of self. Then we review categories of factors that influence how one adjusts to chronic illness, with particular emphasis on the impact of these factors on functional status and psychosocial adjustment. We begin with contextual factors, including demographic variables such as sex and race, as well as illness dimensions such as stigma and illness identity. We then examine a set of dispositional factors that influence chronic illness adjustment, organizing these into resilience and vulnerability factors. Resilience factors include cognitive adaptation indicators, personality variables, and benefit-finding. Vulnerability factors include a pessimistic attributional style, negative gender-related traits, and rumination. We then turn to social environmental variables, including both supportive and unsupportive interactions. Finally, we review chronic illness adjustment within the context of dyadic coping. We conclude by examining potential interactions among these classes of variables and outlining a set of directions for future research.

  19. MCCB warm adjustment testing concept

    NASA Astrophysics Data System (ADS)

    Erdei, Z.; Horgos, M.; Grib, A.; Preradović, D. M.; Rodic, V.

    2016-08-01

    This paper presents an experimental investigation in to operating of thermal protection device behavior from an MCCB (Molded Case Circuit Breaker). One of the main functions of the circuit breaker is to assure protection for the circuits where mounted in for possible overloads of the circuit. The tripping mechanism for the overload protection is based on a bimetal movement during a specific time frame. This movement needs to be controlled and as a solution to control this movement we choose the warm adjustment concept. This concept is meant to improve process capability control and final output. The warm adjustment device design will create a unique adjustment of the bimetal position for each individual breaker, determined when the testing current will flow thru a phase which needs to trip in a certain amount of time. This time is predetermined due to scientific calculation for all standard types of amperages and complies with the IEC 60497 standard requirements.

  20. Comparable-Worth Adjustments: Yes--Comparable-Worth Adjustments: No.

    ERIC Educational Resources Information Center

    Galloway, Sue; O'Neill, June

    1985-01-01

    Two essays address the issue of pay equity and present opinions favoring and opposing comparable-worth adjustments. Movement of women out of traditionally female jobs, the limits of "equal pay," fairness of comparable worth and market-based wages, implementation and efficiency of comparable worth system, and alternatives to comparable…

  1. Peripheral Insertion of a Central Venous Access Device Under Fluoroscopic Guidance Using a Peripherally Accessed System (PAS) Port in the Forearm

    SciTech Connect

    Hata, Yasuhiro; Morita, Sojiro; Morita, Yoshitaka; Awatani, Toshihide; Takasaki, Motohiro; Horimi, Tadashi; Ozawa, Zen

    1998-05-15

    Purpose: We describe the technique, efficacy, and complications of fluoroscopy-guided implantation of a central venous access device using a peripherally accessed system (PAS) port via the forearm. Methods: Beginning in July 1994, 105 central venous access devices were implanted in 104 patients for the long-term infusion of antibiotics or antineoplasmic agents, blood products, or parenteral nutrition. The devices was inserted under fluoroscopic guidance with real-time venography from a peripheral route. Results: All ports were successfully implanted. There were no procedure-related complications. No thrombosis or local infection was observed; however, in six patients catheter-related phlebitis occurred. Conclusion: Fluoroscopy-guided implantation of a central venous access device using a PAS port via the forearm is safe and efficacious, and injection of contrast medium through a peripheral IV catheter before introduction of the catheter helps to avoid catheter-related phlebitis.

  2. The out-of-body experience and personality adjustment.

    PubMed

    Tobacyk, J J; Mitchell, T P

    1987-06-01

    Relationships between the out-of-body experience and personality adjustment were studied. A total of 445 college students, including 65 reporting out-of-body experiences, completed self-report measures of death orientation, defensive style, narcissism, paranormal beliefs, self-concept, and social desirability. No significant differences were found between respondents reporting out-of-body experiences and nonreporters on any of the instruments, except for the Paranormal Belief Scale. Reporters of out-of-body experiences showed significantly greater belief in precognition, psi, spiritualism, and witchcraft than did nonreporters. Findings indicate considerable similarity between reporters and nonreporters in personality adjustment. It is clear that, on these personality adjustment measures, the out-of-body experience was associated with neither less effective nor more effective adjustment.

  3. 75 FR 33379 - Railroad Cost Recovery Procedures-Productivity Adjustment; Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment; Quarterly Rail... Railroads that the Board restate the previously published productivity adjustment for the 2003-2007 averaging period (2007 productivity adjustment) so that it tracks the 2007 productivity adjustment...

  4. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

    PubMed Central

    Wu, Dalei; Su, Xiaoyu; Potluri, Nalini; Kim, Youngchang; Rastinejad, Fraydoon

    2016-01-01

    The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 must each heterodimerize with the aryl hydrocarbon receptor nuclear translocator (ARNT), to form functional transcription complexes capable of DNA binding and gene regulation. Here we examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. Through expanded architectural comparisons between these complexes and HIF-1α-ARNT, HIF-2α-ARNT and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and presents as an ideal class of transcription factors for direct targeting by small-molecule drugs. DOI: http://dx.doi.org/10.7554/eLife.18790.001 PMID:27782878

  5. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

    SciTech Connect

    Wu, Dalei; Su, Xiaoyu; Potluri, Nalini; Kim, Youngchang; Rastinejad, Fraydoon

    2016-10-26

    Here, the neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 must each heterodimerize with the aryl hydrocarbon receptor nuclear translocator (ARNT), to form functional transcription complexes capable of DNA binding and gene regulation. Here we examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. Through expanded architectural comparisons between these complexes and HIF-1α-ARNT, HIF-2α-ARNT and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and presents as an ideal class of transcription factors for direct targeting by small-molecule drugs.

  6. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

    DOE PAGES

    Wu, Dalei; Su, Xiaoyu; Potluri, Nalini; ...

    2016-10-26

    Here, the neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 must each heterodimerize with the aryl hydrocarbon receptor nuclear translocator (ARNT), to form functional transcription complexes capable of DNA binding and gene regulation. Here we examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. Through expanded architectural comparisons between these complexes and HIF-1α-ARNT, HIF-2α-ARNT and CLOCK-BMAL1, we show the widermore » mammalian bHLH-PAS family is capable of multi-ligand-binding and presents as an ideal class of transcription factors for direct targeting by small-molecule drugs.« less

  7. Data on schizotypy and affective scales are gender and education dependent--study in the Northern Finland 1966 Birth Cohort.

    PubMed

    Miettunen, Jouko; Veijola, Juha; Freimer, Nelson; Lichtermann, Dirk; Peltonen, Leena; Paunio, Tiina; Isohanni, Matti; Joukamaa, Matti; Ekelund, Jesper

    2010-07-30

    We present psychometric properties and normative data by gender and educational level in scales related to schizotypy and affective disorders in a large population-based adult sample. As part of the 31-year follow-up survey of the Northern Finland 1966 Birth Cohort; Bipolar II scale (BIP2), Hypomanic Personality Scale (HPS), Physical Anhedonia Scale (PAS), Social Anhedonia Scale (SAS), Perceptual Aberration Scale (PER) and Schizoidia Scale (SCHD) were filled in by 4928 subjects. In total sample mean scores were: BIP2 10.59 (3.80), HPS 11.26 (7.03), PAS 14.99 (S.D. 7.03), SAS 9.44 (5.52), PER 2.35 (3.26) and SCHD 2.56 (1.42). Men scored higher (had more psychopathological symptoms) in PAS and SAS (P<0.001), and in BIP2 (P=0.02). Women had higher scores in SCHD, HPS and PER (P<0.001). Participants with a lower level of education scored higher in all scales; differences were largest in BIP2, PAS and SAS (ES>0.5,P<0.001). The gender and education differences were moderate or large in all the included scales. These differences should be taken into account when considering normal values in these scales. The findings indicate that commonly used student samples are likely to be biased when compared to community based samples.

  8. Adjustable Optical-Fiber Attenuator

    NASA Technical Reports Server (NTRS)

    Buzzetti, Mike F.

    1994-01-01

    Adjustable fiber-optic attenuator utilizes bending loss to reduce strength of light transmitted along it. Attenuator functions without introducing measurable back-reflection or insertion loss. Relatively insensitive to vibration and changes in temperature. Potential applications include cable television, telephone networks, other signal-distribution networks, and laboratory instrumentation.

  9. Dyadic Adjustment: An Ecosystemic Examination.

    ERIC Educational Resources Information Center

    Wilson, Stephan M.; Larson, Jeffry H.; McCulloch, B. Jan; Stone, Katherine L.

    1997-01-01

    Examines the relationship of background, individual, and family influences on dyadic adjustment, using an ecological perspective. Data from 102 married couples were used. Age at marriage for husbands, emotional health for wives, and number of marriage and family problems as well as family life satisfaction for both were related to dyadic…

  10. Problems of Adjustment to School.

    ERIC Educational Resources Information Center

    Bartolini, Leandro A.

    This paper, one of several written for a comprehensive policy study of early childhood education in Illinois, examines and summarizes the literature on the problems of young children in adjusting to starting school full-time and describes the nature and extent of their difficulties in relation to statewide educational policy. The review of studies…

  11. Economic Pressures and Family Adjustment.

    ERIC Educational Resources Information Center

    Haccoun, Dorothy Markiewicz; Ledingham, Jane E.

    The relationships between economic stress on the family and child and parental adjustment were examined for a sample of 199 girls and boys in grades one, four, and seven. These associations were examined separately for families in which both parents were present and in which mothers only were at home. Economic stress was associated with boys'…

  12. The Impact of Financial Sophistication on Adjustable Rate Mortgage Ownership

    ERIC Educational Resources Information Center

    Smith, Hyrum; Finke, Michael S.; Huston, Sandra J.

    2011-01-01

    The influence of a financial sophistication scale on adjustable-rate mortgage (ARM) borrowing is explored. Descriptive statistics and regression analysis using recent data from the Survey of Consumer Finances reveal that ARM borrowing is driven by both the least and most financially sophisticated households but for different reasons. Less…

  13. Psychological Adjustment and Neuropsychological Performance in Diabetic Patients.

    ERIC Educational Resources Information Center

    Skenazy, Judy A.; Bigler, Erin D.

    1985-01-01

    Compared diabetic (N=39) with nondiabetic chronic illness patients (N=20) and healthy controls (N=24). The chronic illness and the diabetic groups had significant elevations on the Hypochondriasis, Depression, and Hysteria scales of the Feschingbauer Abbreviated MMPI. For diabetics, results demonstrated a negligible effect of poor adjustment on…

  14. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount of each civil money penalty within the OCC's jurisdiction is adjusted in accordance with the...

  15. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...

  16. 12 CFR 19.240 - Inflation adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...

  17. Adjusting to University: The Hong Kong Experience

    ERIC Educational Resources Information Center

    Yau, Hon Keung; Sun, Hongyi; Cheng, Alison Lai Fong

    2012-01-01

    Students' adjustment to the university environment is an important factor in predicting university outcomes and is crucial to their future achievements. University support to students' transition to university life can be divided into three dimensions: academic adjustment, social adjustment and psychological adjustment. However, these…

  18. Scales, scales and more scales.

    PubMed

    Weitzenhoffer, Andre M

    2002-01-01

    This article examines the nature, uses, and limitations of the large variety of existing, so-called, hypnosis scales; that is, instruments that have been proposed for the assessment of hypnotic behavior. Although the major aim of most of the scales ostensively seems to be to assess several aspects of hypnotic states, they are found generally to say little about these and much more about responses to suggestions. The greatest application of these scales is to be found in research, but they also have a limited place in clinical work.

  19. Coverage-adjusted entropy estimation.

    PubMed

    Vu, Vincent Q; Yu, Bin; Kass, Robert E

    2007-09-20

    Data on 'neural coding' have frequently been analyzed using information-theoretic measures. These formulations involve the fundamental and generally difficult statistical problem of estimating entropy. We review briefly several methods that have been advanced to estimate entropy and highlight a method, the coverage-adjusted entropy estimator (CAE), due to Chao and Shen that appeared recently in the environmental statistics literature. This method begins with the elementary Horvitz-Thompson estimator, developed for sampling from a finite population, and adjusts for the potential new species that have not yet been observed in the sample-these become the new patterns or 'words' in a spike train that have not yet been observed. The adjustment is due to I. J. Good, and is called the Good-Turing coverage estimate. We provide a new empirical regularization derivation of the coverage-adjusted probability estimator, which shrinks the maximum likelihood estimate. We prove that the CAE is consistent and first-order optimal, with rate O(P)(1/log n), in the class of distributions with finite entropy variance and that, within the class of distributions with finite qth moment of the log-likelihood, the Good-Turing coverage estimate and the total probability of unobserved words converge at rate O(P)(1/(log n)(q)). We then provide a simulation study of the estimator with standard distributions and examples from neuronal data, where observations are dependent. The results show that, with a minor modification, the CAE performs much better than the MLE and is better than the best upper bound estimator, due to Paninski, when the number of possible words m is unknown or infinite.

  20. An assessment of marital adjustment in patients with rheumatoid arthritis.

    PubMed

    Resorlu, Hatice; Sahin, Basak; Ertekin, Hulya; Bilim, Serhad; Savas, Yılmaz

    2017-02-01

    Aim To investigate marital adjustment in patients with rheumatoid arthritis and factors affecting this. Methods A total of 32 patients diagnosed with Steinbrocker class 1-2 rheumatoid arthritis and 32 healthy individuals from a similar age group were included. Sociodemographic characteristics, the Beck Depression Inventory (BDI), short-form 36(SF-36) and the dyadic adjustment scale (DAS) were evaluated in both groups. A visual analogue scale (VAS), the disease activity score 28(DAS28) and a health assessment questionnaire (HAQ) were also investigated in the patient group. Results Mean ages were 46.5±9.2 years in the patient group and 47.7±8.1 in the control group (p=0.5). No significant difference was determined between the two groups in terms of sociodemographic characteristics. No statistically significant correlation was observed between erythrocyte sedimentation rate (ESR), patient and physician global VAS, DAS28, HAQ and morning stiffness and DAS total score. Comparison of DAS subunits revealed a significant difference in dyadic satisfaction and affectional expression in the patient and control groups (p=0.046 and p=0.037). A statistically significant negative correlation was observed between duration of the disease and marital adjustment (p=0.01;r= -0.58). Conclusion Due to its progressive and prolonged course rheumatoid arthritis can also affect individuals' social relationships besides restricted daily living activities. Activation of rheumatoid arthritis did not affect marital adjustment in this study, but adjustment decreased with duration of the disease.

  1. Geometry and petrophysical parameters of a calcarenitic turbidite lobe (Barremian-Aptian, Pas-de-la-Cluse, France)

    NASA Astrophysics Data System (ADS)

    Savary, Bérengère; Ferry, Serge

    2004-06-01

    Several bioclastic resedimentation systems, late Barremian to early Aptian in age, outcrop in southeastern France. The upslope portion of a calcarenitic turbidite lobe outcrops as a cliff, 2.3 km wide and up to 45 m high, oriented roughly perpendicular to the direction of palaeoflow. It has been studied through 31 sections. The studied body is point-sourced and corresponds to a channel/lobe transition located at the toe-of-slope of a Urgonian carbonate platform on the western edge of the Vocontian Trough (French Subalpine Chains). The internal geometry of the lobe is the result of repeated erosion and filling of channels, creating well-defined stacked units. Filling phases result in lobe-shaped morphology. Units evolve from base to top in an ordered way. First, the sediments exported from the platform and deposited in the basin are represented by decimetre-thick, sheet-like and fine-grained Bouma a-e and ab-e sequences. In this first unit, erosion is limited and represented by shallow and symmetrical channels. This initial phase of deposition corresponds to the formation of a lobe with a positive morphology. The next phase of system development is more erosional and this is dominated by migrating, sinuous channels several metres deep filled with coarse-grained, poorly graded turbidites. These channels are first filled through lateral accretion and then sediment spills over to create a sub-lobe. The mixture of channel and lobe features could be considered as a carbonate equivalent of the channel-levee system of siliciclastic deposits. Finally, the system ends with the deposition of a flat-based unit. This unit extends for more than 2 km and is composed of the southwards lateral accretion of hundreds of metres wide sequences each composed of a debris-flow deposit capped by a coarse-grained calcarenite bed. These sigmoidal bodies could be the ultimate forms of a spreading out phenomenon of the lobe. Overall, the Pas-de-la-Cluse system is a coarsening-upward body. As

  2. The relationship between life adjustment and parental bonding in military personnel with adjustment disorder in Taiwan.

    PubMed

    For-Wey, Lung; Fei-Yin, Lee; Bih-Ching, Shu

    2002-08-01

    The aim of the present study was to examine the characteristics of military personnel with adjustment disorder to give them more appropriate treatment. The participants were 36 military personnel who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria of adjustment disorder as diagnosed by a psychiatrist at a teaching hospital in southern Taiwan. Another 24 persons were recruited as an age-matched control group. Each individual completed the clinical interview and the Wechsler Adult Intelligence Scale-Revised and then completed the questionnaires which included demographic information, the Parental Bonding Instrument, the Eysenck Personality Questionnaire, and the Chinese Health Questionnaire. We found statistically significant differences between the case and control groups in personality and parental bonding attitudes. Soldiers with higher neuroticism, lower extraversion, and maternal overprotection had an increased risk of suffering from adjustment disorder. The inclusion of family function and the military environment and such other factors as cultural variables is recommended for future study. The statistical approach of structural equation modeling also should be considered in future studies to determine competing risk factors and mediating effects.

  3. Inflation Adjustments for Defense Acquisition

    DTIC Science & Technology

    2014-10-01

    Harmon Daniel B. Levine Stanley A. Horowitz, Project Leader INSTITUTE FOR DEFENSE ANALYSES 4850 Mark Center Drive Alexandria, Virginia 22311-1882 Approved...T U T E F O R D E F E N S E A N A L Y S E S IDA Document D-5112 Inflation Adjustments for Defense Acquisition Bruce R. Harmon Daniel B. Levine...might do a better job? The focus of the study is on aircraft procurement. By way of terminology , “cost index,” “price index,” and “deflator” are used

  4. Adjustable extender for instrument module

    DOEpatents

    Sevec, J.B.; Stein, A.D.

    1975-11-01

    A blank extender module used to mount an instrument module in front of its console for repair or test purposes has been equipped with a rotatable mount and means for locking the mount at various angles of rotation for easy accessibility. The rotatable mount includes a horizontal conduit supported by bearings within the blank module. The conduit is spring-biased in a retracted position within the blank module and in this position a small gear mounted on the conduit periphery is locked by a fixed pawl. The conduit and instrument mount can be pulled into an extended position with the gear clearing the pawl to permit rotation and adjustment of the instrument.

  5. Characterization of CgHIFα-Like, a Novel bHLH-PAS Transcription Factor Family Member, and Its Role under Hypoxia Stress in the Pacific Oyster Crassostrea gigas

    PubMed Central

    Wang, Ting; Meng, Jie; Li, Li; Zhang, Guofan

    2016-01-01

    Hypoxia-inducible factor (HIF), a critical member of the basic-helix-loop-helix (bHLH)-containing Per-Arnt-Sim (PAS) protein family, is a master transcription factor involved in maintaining oxygen homeostasis. In the present study, we isolated and characterized a novel bHLH-PAS family member, CgHIFα-like gene, from the Pacific oyster Crassostrea gigas, and determined its importance during hypoxia stress. The 3020-bp CgHIFα-like cDNA encoded a protein of 888 amino acids. The predicted CgHIFα-like amino acid sequence was conserved in the N-terminal bHLH, PAS, and PAC domains (but not in the C-terminal domain) and was most closely related to the HIF family in the bHLH-PAS protein phylogenic tree. Similar to the mammalian HIF-1α, CgHIFα-like could be expressed as four mRNA isoforms containing alternative 5′-untranslated regions and different translation initiation codons. At the mRNA level, these isoforms were expressed in a tissue-specific manner and showed increased transcription to varying degrees under hypoxic conditions. Additionally, the western blot analysis demonstrated that CgHIFα-like was induced by hypoxia. Electrophoretic mobility shift assay indicated that CgHIFα-like could bind to the hypoxia responsive element (HRE), whereas dual-luciferase reporter analysis demonstrated that CgHIFα-like could transactivate the reporter gene containing the HREs. In addition to CgHIFα-like, we identified CgARNT from the C. gigas, analyzed its expression pattern, and confirmed its interaction with CgHIFα-like using a yeast two-hybrid assay. In conclusion, this is the first report on the cloning and characterization of a novel hypoxia transcription factor in mollusks, which could accumulate under hypoxia and regulate hypoxia related gene expression by binding to HRE and dimerizing with CgARNT. As only one member of HIF has been identified in invertebrates to date, our results provide new insights into the unique mechanisms of hypoxia tolerance in mollusks. PMID

  6. A Multivariate Analysis of Emotional and Behavioral Adjustment and Preschool Educational Outcomes

    ERIC Educational Resources Information Center

    Fantuzzo, John; Bulotsky, Rebecca; McDermott, Paul; Mosca, Samuel; Lutz, Megan Noone

    2003-01-01

    The study examined the multivariate relationship between dimensions of preschool emotional and behavioral adjustment assessed at the beginning of the year by the Adjustment Scales for Preschool Intervention (ASPI) and multiple learning and social competencies at the end of the year with an urban Head Start sample. This study also examined the…

  7. The Impact of TV Viewing Motivations on Psychological and Sociocultural Adjustment.

    ERIC Educational Resources Information Center

    Chen, Guo-Ming

    A study examined the impact of TV viewing motivations on 126 Asian students' psychological and sociocultural adjustment. Subjects were enrolled in a midsize university in the New England area. TV viewing motivation was measured by A. M. Rubin's TV Viewing Motivations Scale. Psychological adjustment was measured by W. Zung's Self Rating Depression…

  8. Rural Elderly: Impact of Social, Psychological Health and Demographic Experiences on Adjustment in Women and Men.

    ERIC Educational Resources Information Center

    Maiden, R.; And Others

    An amended form of the Older American's Status and Needs Assessment Questionnaire assessed the prevalence of adjustment, as measured by the Bradburn Affect Scale, in a random stratified sample of 301 female and 140 male elderly rural residents in Allegany County, New York. The relationship between adjustment and biosocial, demographic, social, and…

  9. The dyadic adjustment of female-to-male transsexuals.

    PubMed

    Fleming, M; MacGowan, B; Costos, D

    1985-02-01

    Dyadic adjustment, sexual activities, and marital stability in the relationships of female-to-male transsexuals and their spouses were examined. Participants were 22 female-to-male transsexuals who had undergone some form of surgery to alter their anatomical sex, their spouses, and a control group of married or cohabitating nontranssexual men and women. Participants were administered the Dyadic Adjustment Scale and additional items to assess quantitatively their marital relationships. The transsexuals and their spouses were also asked open-ended interview questions concerning marital and life adjustments. Generally, the transsexuals and their spouses reported good and mutually satisfying interpersonal relationships that are in many ways comparable to those of the matched control group. These findings lend support to the previous clinical interview studies that have reported that female-to-male transsexuals form stable and enduring intimate relationships.

  10. Adjusting the Contour of Reflector Panels

    NASA Technical Reports Server (NTRS)

    Palmer, W. B.; Giebler, M. M.

    1984-01-01

    Postfabrication adjustment of contour of panels for reflector, such as parabolic reflector for radio antennas, possible with simple mechanism consisting of threaded stud, two nuts, and flexure. Contours adjusted manually.

  11. 48 CFR 1450.103 - Contract adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract adjustments. 1450.103 Section 1450.103 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT... Contract adjustments....

  12. First Year Adjustment in the Secondary School.

    ERIC Educational Resources Information Center

    Loosemore, Jean Ann

    1978-01-01

    This study investigated the relationship between adjustment to secondary school and 17 cognitive and noncognitive variables, including intelligence (verbal and nonverbal reasoning), academic achievement, extraversion-introversion, stable/unstable, social adjustment, endeavor, age, sex, and school form. (CP)

  13. Exploring Scaling: From Concept to Applications

    ERIC Educational Resources Information Center

    Milner-Bolotin, Marina

    2009-01-01

    This paper discusses the concept of scaling and its biological and engineering applications. Scaling, in a scientific context, means proportional adjustment of the dimensions of an object so that the adjusted and original objects have similar shapes yet different dimensions. The paper provides an example of a hands-on, minds-on activity on scaling…

  14. Magnetron injection gun scaling

    NASA Astrophysics Data System (ADS)

    Lawson, W.

    1988-04-01

    A set of tradeoff equations was simplified to obtain scaling laws for magnetron injection guns (MIGs). The constraints are chosen to examine the maximum-peak-power capabilities of MIGs. The scaling laws are compared with exact solutions of the design equations and are supported by MIG simulations in which each MIG is designed to double the beam power of an existing design by adjusting one of the four fundamental parameters.

  15. Generalized adjustment by least squares ( GALS).

    USGS Publications Warehouse

    Elassal, A.A.

    1983-01-01

    The least-squares principle is universally accepted as the basis for adjustment procedures in the allied fields of geodesy, photogrammetry and surveying. A prototype software package for Generalized Adjustment by Least Squares (GALS) is described. The package is designed to perform all least-squares-related functions in a typical adjustment program. GALS is capable of supporting development of adjustment programs of any size or degree of complexity. -Author

  16. 49 CFR 393.53 - Automatic brake adjusters and brake adjustment indicators.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... brake adjustment indicators. (a) Automatic brake adjusters (hydraulic brake systems). Each commercial motor vehicle manufactured on or after October 20, 1993, and equipped with a hydraulic brake...

  17. The Ability of PAS, Acetylsalicylic Acid and Calcium Disodium EDTA to Protect Against the Toxic Effects of Manganese on Mitochondrial Respiration in Gill of Crassostrea virginica

    PubMed Central

    Crawford, Sherine; Davis, Kiyya; Saddler, Claudette; Joseph, Jevaun; Catapane, Edward J.; Carroll, Margaret A.

    2011-01-01

    Manganese (Mn) is an essential metal that at excessive levels in brain causes Manganism, a condition similar to Parkinson's disease. Previously we showed that Mn had a neurotoxic effect on the dopaminergic, but not serotonergic, innervation of the lateral ciliated cells in the gill of the Eastern Oyster, Crassostrea virginica. While the mechanism of action of Mn toxicity is not completely understood, studies suggest that Mn toxicity may involve mitochondrial damage and resulting neural dysfunction in the brain’s dopaminergic system. In this study we utilized micro-batch chambers and oxygen probes to measure oyster gill mitochondrial respiration in the presence of Mn and potential Mn blockers. The addition of Mn to respiring mitochondria caused a dose dependent decrease in mitochondrial O2 consumption. Pretreating mitochondria with calcium disodium EDTA (caEDTA), p aminosalicylic acid (PAS) or acetylsalicylic acid (ASA) before Mn additions, provided full protection against the toxic effects of Mn. While mitochondrial pretreatment with any of the 3 drugs effectively blocked Mn toxicity, none of the drugs tested was able to reverse the decrease in mitochondrial O2 consumption seen in Mn treated mitochondria. The study found that high levels of Mn had a toxic effect on gill mitochondrial O2 consumption and that this effect could be blocked by the drugs caEDTA, PAS and ASA. C. virginica continues to be a good model with which to investigate the mechanism that underlies manganese neurotoxcity and in the pharmacological study of drugs to treat or prevent Manganism. PMID:21977482

  18. The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition.

    PubMed

    Machuca, Mayra A; Liu, Yu C; Beckham, Simone A; Gunzburg, Menachem J; Roujeinikova, Anna

    2016-05-01

    Chemotaxis and motility play an important role in the colonisation of avian and human hosts by Campylobacter jejuni. Chemotactic recognition of extracellular signals is mediated by the periplasmic sensing domain of methyl-accepting chemotactic proteins (membrane-embedded receptors). In this work, we report a high-resolution structure of the periplasmic sensing domain of transducer-like protein 1 (Tlp1), an aspartate receptor of C. jejuni. Crystallographic analysis revealed that it contains two Per-Arnt-Sim (PAS) subdomains. An acetate and chloride ions (both from the crystallisation buffer) were observed bound to the membrane-proximal and membrane-distal PAS subdomains, respectively. Surprisingly, despite being crystallised in the presence of aspartate, the structure did not show any electron density corresponding to this amino acid. Furthermore, no binding between the sensing domain of Tlp1 and aspartate was detected by microcalorimetric experiments. These structural and biophysical data suggest that Tlp1 does not sense aspartate directly; instead, ligand recognition is likely to occur indirectly via an as yet unidentified periplasmic binding protein.

  19. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels.

    PubMed

    Flamme, I; Fröhlich, T; von Reutern, M; Kappel, A; Damert, A; Risau, W

    1997-04-01

    Transcription factors of the bHLH-PAS protein family are important regulators of developmental processes such as neurogenesis and tracheal development in invertebrates. Recently a bHLH-PAS protein, named trachealess (trl) was identified as a master regulator of tracheogenesis. Hypoxia-inducible factor, HIF-1 alpha, is a vertebrate relative of trl which is likely to be involved in growth of blood vessels by the induction of vascular endothelial growth factor (VEGF) in response to hypoxia. In the present study we describe mRNA cloning and mRNA expression pattern of mouse HIF-related factor (HRF), a novel close relative of HIF-1 alpha which is expressed most prominently in brain capillary endothelial cells and other blood vessels as well as in bronchial epithelium in the embryo and the adult. In addition, smooth muscle cells of the uterus, neurons, brown adipose tissue and various epithelial tissues express HRF mRNA as well. High expression levels of HRF mRNA in embryonic choroid plexus and kidney glomeruli, places where VEGF is highly expressed, suggest a role of this factor in VEGF gene activation similar to that of HIF-1 alpha. Given the similarity between morphogenesis of the tracheal system and the vertebrate vascular system, the expression pattern of HRF in the vasculature and the bronchial tree raises the possibility that this family of transcription factors may be involved in tubulogenesis.

  20. The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain.

    PubMed

    Reinelt, Stefan; Hofmann, Eckhard; Gerharz, Tanja; Bott, Michael; Madden, Dean R

    2003-10-03

    The integral membrane sensor kinase CitA of Klebsiella pneumoniae is part of a two-component signal transduction system that regulates the transport and metabolism of citrate in response to its environmental concentration. Two-component systems are widely used by bacteria for such adaptive processes, but the stereochemistry of periplasmic ligand binding and the mechanism of signal transduction across the membrane remain poorly understood. The crystal structure of the CitAP periplasmic sensor domain in complex with citrate reveals a PAS fold, a versatile ligand-binding structural motif that has not previously been observed outside the cytoplasm or implicated in the transduction of conformational signals across the membrane. Citrate is bound in a pocket that is shared among many PAS domains but that shows structural variation according to the nature of the bound ligand. In CitAP, some of the citrate contact residues are located in the final strand of the central beta-sheet, which is connected to the C-terminal transmembrane helix. These secondary structure elements thus provide a potential conformational link between the periplasmic ligand binding site and the cytoplasmic signaling domains of the receptor.

  1. Characterization of a c-type heme-containing PAS sensor domain from Geobacter sulfurreducens representing a novel family of periplasmic sensors in Geobacteraceae and other bacteria.

    PubMed

    Londer, Yuri Y; Dementieva, Irina S; D'Ausilio, Cori A; Pokkuluri, P Raj; Schiffer, Marianne

    2006-05-01

    Geobacter sulfurreducens encodes one of the largest numbers of proteins annotated as parts of the two-component signal transduction and/or chemotaxis pathways. Ten of these signal transducers have homologous periplasmic sensor domains that contain the sequence signature for c-type hemes. One such sensor domain encoded by gene GSU0303 was isolated and characterized. The protein was expressed in Escherichia coli and was isolated as two colored species (green and red). The green species is a monomer of the sensor domain with a five-coordinated high-spin heme and the red species is probably a noncovalent dimer of the sensor domain which might have an uncharacterized ligand bound to the dimer. The UV-VIS spectrum of the green species indicates that it has a c'-type heme, but its structure is predicted to be homologous to CitA, a periplasmic PAS domain that does not contain heme. The GSU0303 sensor domain represents a previously unreported family of PAS-type periplasmic sensor domains that contain c-type hemes; these proteins could be part of an important mechanism for sensing redox potential or small ligands in the periplasm. Homologs to the sensor domains we identified in G. sulfurreducens are observed in various bacteria although they occur in larger numbers in the Geobacteraceae.

  2. The PAS domain-containing histidine kinase RpfS is a second sensor for the diffusible signal factor of Xanthomonas campestris.

    PubMed

    An, Shi-Qi; Allan, John H; McCarthy, Yvonne; Febrer, Melanie; Dow, J Maxwell; Ryan, Robert P

    2014-05-01

    A cell-cell signalling system mediated by the fatty acid signal DSF controls the virulence of Xanthomonas campestris pv. campestris (Xcc) to plants. The synthesis and recognition of the DSF signal depends upon different Rpf proteins. DSF signal generation requires RpfF whereas signal perception and transduction depends upon the sensor RpfC and regulator RpfG. Detailed analyses of the regulatory roles of different Rpf proteins have suggested the occurrence of further sensors for DSF. Here we have used a mutagenesis approach coupled with high-resolution transcriptional analysis to identify XC_2579 (RpfS) as a second sensor for DSF in Xcc. RpfS is a complex sensor kinase predicted to have multiple Per/Arnt/Sim (PAS) domains, a histidine kinase domain and a C-terminal receiver (REC) domain. Isothermal calorimetry showed that DSF bound to the isolated N-terminal PAS domain with a Kd of 1.4 μM. RpfS controlled expression of a sub-set of genes distinct from those controlled by RpfC to include genes involved in type IV secretion and chemotaxis. Mutation of XC_2579 was associated with a reduction in virulence of Xcc to Chinese Radish when assayed by leaf spraying but not by leaf inoculation, suggesting a role for RpfS-controlled factors in the epiphytic phase of the disease cycle.

  3. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in a budget account, the borrower may request RUS's approval of a budget adjustment to use funds from...

  4. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in a budget account, the borrower may request RUS's approval of a budget adjustment to use funds from...

  5. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in a budget account, the borrower may request RUS's approval of a budget adjustment to use funds from...

  6. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in a budget account, the borrower may request RUS's approval of a budget adjustment to use funds from...

  7. 7 CFR 1744.64 - Budget adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Budget adjustment. 1744.64 Section 1744.64... Disbursement of Funds § 1744.64 Budget adjustment. (a) If more funds are required than are available in a budget account, the borrower may request RUS's approval of a budget adjustment to use funds from...

  8. 24 CFR 5.611 - Adjusted income.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Adjusted income. 5.611 Section 5... Serving Persons with Disabilities: Family Income and Family Payment; Occupancy Requirements for Section 8 Project-Based Assistance Family Income § 5.611 Adjusted income. Adjusted income means annual income...

  9. 24 CFR 5.611 - Adjusted income.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Adjusted income. 5.611 Section 5... Serving Persons with Disabilities: Family Income and Family Payment; Occupancy Requirements for Section 8 Project-Based Assistance Family Income § 5.611 Adjusted income. Adjusted income means annual income...

  10. 19 CFR 201.205 - Salary adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Salary adjustments. 201.205 Section 201.205 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt Collection § 201.205 Salary adjustments. Any negative adjustment to pay arising out of an employee's...

  11. 19 CFR 201.205 - Salary adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Salary adjustments. 201.205 Section 201.205 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt Collection § 201.205 Salary adjustments. Any negative adjustment to pay arising out of an employee's...

  12. 12 CFR 313.55 - Salary adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Salary adjustments. 313.55 Section 313.55 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT COLLECTION Salary Offset § 313.55 Salary adjustments. Any negative adjustment to pay...

  13. 12 CFR 313.55 - Salary adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Salary adjustments. 313.55 Section 313.55 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT COLLECTION Salary Offset § 313.55 Salary adjustments. Any negative adjustment to pay...

  14. 12 CFR 313.55 - Salary adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Salary adjustments. 313.55 Section 313.55 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT COLLECTION Salary Offset § 313.55 Salary adjustments. Any negative adjustment to pay...

  15. 12 CFR 313.55 - Salary adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Salary adjustments. 313.55 Section 313.55 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT COLLECTION Salary Offset § 313.55 Salary adjustments. Any negative adjustment to pay...

  16. 19 CFR 201.205 - Salary adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Salary adjustments. 201.205 Section 201.205 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt Collection § 201.205 Salary adjustments. Any negative adjustment to pay arising out of an employee's...

  17. 19 CFR 201.205 - Salary adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Salary adjustments. 201.205 Section 201.205 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt Collection § 201.205 Salary adjustments. Any negative adjustment to pay arising out of an employee's...

  18. 19 CFR 201.205 - Salary adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Salary adjustments. 201.205 Section 201.205 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt Collection § 201.205 Salary adjustments. Any negative adjustment to pay arising out of an employee's...

  19. 12 CFR 313.55 - Salary adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Salary adjustments. 313.55 Section 313.55 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT COLLECTION Salary Offset § 313.55 Salary adjustments. Any negative adjustment to pay...

  20. 12 CFR 1780.80 - Inflation adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Inflation adjustments. 1780.80 Section 1780.80... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Civil Money Penalty Inflation Adjustments § 1780.80 Inflation adjustments. The maximum amount of each civil money penalty within...

  1. 12 CFR 1780.80 - Inflation adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Inflation adjustments. 1780.80 Section 1780.80... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Civil Money Penalty Inflation Adjustments § 1780.80 Inflation adjustments. The maximum amount of each civil money penalty within...

  2. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum,...

  3. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2..., Section 36.2—Civil Monetary Penalty Inflation Adjustments Statute Description New maximum (and minimum,...

  4. Local scale comparisons of biodiversity as a test for global protected area ecological performance: a meta-analysis.

    PubMed

    Coetzee, Bernard W T; Gaston, Kevin J; Chown, Steven L

    2014-01-01

    Terrestrial protected areas (PAs) are cornerstones of global biodiversity conservation. Their efficacy in terms of maintaining biodiversity is, however, much debated. Studies to date have been unable to provide a general answer as to PA conservation efficacy because of their typically restricted geographic and/or taxonomic focus, or qualitative approaches focusing on proxies for biodiversity, such as deforestation. Given the rarity of historical data to enable comparisons of biodiversity before/after PA establishment, many smaller scale studies over the past 30 years have directly compared biodiversity inside PAs to that of surrounding areas, which provides one measure of PA ecological performance. Here we use a meta-analysis of such studies (N = 86) to test if PAs contain higher biodiversity values than surrounding areas, and so assess their contribution to determining PA efficacy. We find that PAs generally have higher abundances of individual species, higher assemblage abundances, and higher species richness values compared with alternative land uses. Local scale studies in combination thus show that PAs retain more biodiversity than alternative land use areas. Nonetheless, much variation is present in the effect sizes, which underscores the context-specificity of PA efficacy.

  5. 27 CFR 19.276 - Package scales.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Package scales. 19.276... Package scales. Proprietors shall ensure the accuracy of scales used for weighing packages of spirits through tests conducted at intervals of not more than 6 months or whenever scales are adjusted or...

  6. Exploration adjustment by ant colonies

    PubMed Central

    2016-01-01

    How do animals in groups organize their work? Division of labour, i.e. the process by which individuals within a group choose which tasks to perform, has been extensively studied in social insects. Variability among individuals within a colony seems to underpin both the decision over which tasks to perform and the amount of effort to invest in a task. Studies have focused mainly on discrete tasks, i.e. tasks with a recognizable end. Here, we study the distribution of effort in nest seeking, in the absence of new nest sites. Hence, this task is open-ended and individuals have to decide when to stop searching, even though the task has not been completed. We show that collective search effort declines when colonies inhabit better homes, as a consequence of a reduction in the number of bouts (exploratory events). Furthermore, we show an increase in bout exploration time and a decrease in bout instantaneous speed for colonies inhabiting better homes. The effect of treatment on bout effort is very small; however, we suggest that the organization of work performed within nest searching is achieved both by a process of self-selection of the most hard-working ants and individual effort adjustment. PMID:26909180

  7. Automatic Focus Adjustment of a Microscope

    NASA Technical Reports Server (NTRS)

    Huntsberger, Terrance

    2005-01-01

    AUTOFOCUS is a computer program for use in a control system that automatically adjusts the position of an instrument arm that carries a microscope equipped with an electronic camera. In the original intended application of AUTOFOCUS, the imaging microscope would be carried by an exploratory robotic vehicle on a remote planet, but AUTOFOCUS could also be adapted to similar applications on Earth. Initially control software other than AUTOFOCUS brings the microscope to a position above a target to be imaged. Then the instrument arm is moved to lower the microscope toward the target: nominally, the target is approached from a starting distance of 3 cm in 10 steps of 3 mm each. After each step, the image in the camera is subjected to a wavelet transform, which is used to evaluate the texture in the image at multiple scales to determine whether and by how much the microscope is approaching focus. A focus measure is derived from the transform and used to guide the arm to bring the microscope to the focal height. When the analysis reveals that the microscope is in focus, image data are recorded and transmitted.

  8. Resonance Parameter Adjustment Based on Integral Experiments

    SciTech Connect

    Sobes, Vladimir; Leal, Luiz; Arbanas, Goran; Forget, Benoit

    2016-06-02

    Our project seeks to allow coupling of differential and integral data evaluation in a continuous-energy framework and to use the generalized linear least-squares (GLLS) methodology in the TSURFER module of the SCALE code package to update the parameters of a resolved resonance region evaluation. We recognize that the GLLS methodology in TSURFER is identical to the mathematical description of a Bayesian update in SAMMY, the SAMINT code was created to use the mathematical machinery of SAMMY to update resolved resonance parameters based on integral data. Traditionally, SAMMY used differential experimental data to adjust nuclear data parameters. Integral experimental data, such as in the International Criticality Safety Benchmark Experiments Project, remain a tool for validation of completed nuclear data evaluations. SAMINT extracts information from integral benchmarks to aid the nuclear data evaluation process. Later, integral data can be used to resolve any remaining ambiguity between differential data sets, highlight troublesome energy regions, determine key nuclear data parameters for integral benchmark calculations, and improve the nuclear data covariance matrix evaluation. Moreover, SAMINT is not intended to bias nuclear data toward specific integral experiments but should be used to supplement the evaluation of differential experimental data. Using GLLS ensures proper weight is given to the differential data.

  9. Resonance Parameter Adjustment Based on Integral Experiments

    DOE PAGES

    Sobes, Vladimir; Leal, Luiz; Arbanas, Goran; ...

    2016-06-02

    Our project seeks to allow coupling of differential and integral data evaluation in a continuous-energy framework and to use the generalized linear least-squares (GLLS) methodology in the TSURFER module of the SCALE code package to update the parameters of a resolved resonance region evaluation. We recognize that the GLLS methodology in TSURFER is identical to the mathematical description of a Bayesian update in SAMMY, the SAMINT code was created to use the mathematical machinery of SAMMY to update resolved resonance parameters based on integral data. Traditionally, SAMMY used differential experimental data to adjust nuclear data parameters. Integral experimental data, suchmore » as in the International Criticality Safety Benchmark Experiments Project, remain a tool for validation of completed nuclear data evaluations. SAMINT extracts information from integral benchmarks to aid the nuclear data evaluation process. Later, integral data can be used to resolve any remaining ambiguity between differential data sets, highlight troublesome energy regions, determine key nuclear data parameters for integral benchmark calculations, and improve the nuclear data covariance matrix evaluation. Moreover, SAMINT is not intended to bias nuclear data toward specific integral experiments but should be used to supplement the evaluation of differential experimental data. Using GLLS ensures proper weight is given to the differential data.« less

  10. Performance of the e2v 1.2 GPix cryogenic camera for the J-PAS 2.5m survey telescope

    NASA Astrophysics Data System (ADS)

    Robbins, M. S.; Bastable, M.; Bates, A.; Dryer, M.; Eames, S.; Fenemore-Jones, G.; Haddow, G.; Jorden, P. R.; Lane, B.; Marin-Franch, A.; Mortimer, J.; Palmer, I.; Puttay, N.; Renshaw, R.; Smith, M.; Taylor, K.; Tearle, J.; Weston, P.; Wheeler, P.; Worley, J.

    2016-08-01

    The J-PAS project will perform a five-year survey of the northern sky from a new 2.5m telescope in Teruel, Spain. In this paper the build and factory testing of the commercially supplied cryogenic camera is described. The 1.2 Giga-pixel focal plane is contained within a novel liquid-nitrogen cooled vacuum cryostat, which maintains the flatness for the cooled, 0.45m diameter focal plane to better than 27 μm peak to valley. The cooling system controls the focal plane to a temperature of -100°C with a variation across the focal plane of better than 2.5oC and a stability of better than +/- 0.5 °C over the long periods of operation required. The proximity drive electronics achieves total system level noise performance better than 5 e- from the 224-channel CCD system.

  11. [First analysis of the deployment of the ethical approach in the field of mental health in the Nord Pas-de-Calais region].

    PubMed

    Boury, Dominique; François, Guillaume; Danel, Thierry; Cobbaut, Jean-Philippe

    2012-01-01

    For 3 years, the Regional Federation of Mental Health Research (F2RSM) has led a space ethics reflexion Department of mental health (ERESM) to federate structures that ethical institutions and mental health services have been creating in the Nord-Pas de Calais. This approach is, in many ways, revealing issues that involve the institutionalisation of ethical reflection in care facilities. In this article, after referring to the major developments in this field, we describe the conditions for the emergence of ethical bodies in the region. Through the choice of development and operation of the ethical reflexion department, we highlight a number of points of attention that illustrate the complex articulation between institutional expectations and concerns of professionals. The trajectory of the ERESM is thus revealed as a process of reflective learning open to all stakeholders, providers and users of mental health.

  12. A PAS domain with an oxygen labile [4Fe-4S](2+) cluster in the oxygen sensor kinase NreB of Staphylococcus carnosus.

    PubMed

    Müllner, Martin; Hammel, Oliver; Mienert, Bernd; Schlag, Steffen; Bill, Eckhard; Unden, Gottfried

    2008-12-30

    The cytoplasmic histidine sensor kinase NreB of Staphylococcus carnosus responds to O(2) and controls together with the response regulator NreC the expression of genes of nitrate/nitrite respiration. nreBC homologous genes were found in Staphylococcus strains and Bacillus clausii, and a modified form was found in some Lactobacillus strains. NreB contains a sensory domain with similarity to heme B binding PAS domains. Anaerobically prepared NreB of S. carnosus exhibited a (diamagnetic) [4Fe-4S](2+) cluster when assessed by Mossbauer spectroscopy. Upon reaction with air, the cluster was degraded with a half-life of approximately 2.5 min. No significant amounts of Mossbauer or EPR detectable intermediates were found during the decay, but magnetic Mossbauer spectra revealed formation of diamagnetic [2Fe-2S](2+) clusters. After extended exposure to air, NreB was devoid of a FeS cluster. Photoreduction with deazaflavin produced small amounts of [4Fe-4S](+), which were degraded subsequently. The magnetically perturbed Mossbauer spectrum of the [4Fe-4S](2+) cluster corroborated the S = 0 spin state and revealed uniform electric field gradient tensors of the iron sites, suggesting full delocalization of the valence electrons and binding of each of the Fe ions by four S ligands, including the ligand to the protein. Mutation of each of the four Cys residues inactivated NreB function in vivo in accordance with their role as ligands. [4Fe-4S](2+) cluster-containing NreB had high kinase activity. Exposure to air decreased the kinase activity and content of the [4Fe-4S](2+) cluster with similar half-lives. We conclude that the sensory domain of NreB represents a new type of PAS domain containing a [4Fe-4S](2+) cluster for sensing and function.

  13. A concurrent comparison of intermittent (twice-weekly) isoniazid plus streptomycin and daily isoniazid plus PAS in the domiciliary treatment of pulmonary tuberculosis

    PubMed Central

    1964-01-01

    Previous reports from the Tuberculosis Chemotherapy Centre, Madras, have established that ambulatory treatment of pulmonary tuberculosis with the combination of isoniazid and PAS, administered daily, yields satisfactory results. However, in the usage of any unsupervised regimen, reliance must be placed on the co-operation of patients in self-administering their drugs. Irregularities in drug-taking, which are not uncommon, may lead to unfavourable therapeutic results; this might be avoided by supervised administration of the drugs. Daily supervision is clearly impracticable in developing countries but regimens in which the drug is administered intermittently—say, twice a week or less frequently—are, if effective, more likely to gain general application. This paper presents the results of a controlled study of a fully supervised intermittent regimen of isoniazid (12.5-16.1 mg/kg body-weight, orally) plus streptomycin (injected in a uniform dose of 1 g), given together twice weekly, compared with a standard, unsupervised, daily, oral regimen of isoniazid (3.7-6.3 mg/kg body-weight) plus sodium PAS (0.2-0.3 g/kg body-weight), given in two doses. The intermittent regimen was at least as effective as the standard oral regimen, and although the incidence of temporary giddiness in patients receiving this regimen was rather high, this did not appear to have any long-term importance nor did it appear unduly to affect the co-operation of the patients. These encouraging findings suggest a possible change in the orientation of drug-administration for tuberculosis in developing countries. PMID:14253243

  14. A PP2C phosphatase containing a PAS domain is required to convey signals of energy stress to the sigmaB transcription factor of Bacillus subtilis.

    PubMed

    Vijay, K; Brody, M S; Fredlund, E; Price, C W

    2000-01-01

    The sigmaB transcription factor of the bacterium Bacillus subtilis is activated by growth-limiting energy or environmental challenge to direct the synthesis of more than 100 general stress proteins. Although the signal transduction pathway that conveys these stress signals to sigmaB is becoming increasingly well understood, how environmental or energy stress signals enter this pathway remains unknown. We show here that two PP2C serine phosphatases - RsbP, which is required for response to energy stress, and RsbU, which is required for response to environmental stress - each converge on the RsbV regulator of sigmaB. According to the current understanding of sigmaB regulation, in unstressed cells the phosphorylated RsbV anti-anti-sigma is unable to complex the RsbW anti-sigma, which is then free to bind and inactivate sigmaB. We can now advance the model that either PP2C phosphatase, when triggered by its particular class of stress, can remove the phosphate from RsbV and thereby activate sigmaB. The action of the previously described RsbU is known to be controlled by dedicated upstream signalling components that are activated by environmental stress. The action of the RsbP phosphatase described here requires an energy stress, which we suggest is sensed, at least in part, by the PAS domain in the amino-terminal region of the RsbP phosphatase. In other bacterial signalling proteins, similar PAS domains and their associated chromophores directly sense changes in intracellular redox potential to control the activity of a linked output domain.

  15. DAC-3 Pointing Stability Analysis Results for SAGE 3 and Other Users of the International Space Station (ISS) Payload Attachment Sites (PAS)

    NASA Technical Reports Server (NTRS)

    Woods-Vedeler, Jessica A.; Rombado, Gabriel

    1997-01-01

    The purpose of this paper is to provide final results of a pointing stability analysis for external payload attachment sites (PAS) on the International Space Station (ISS). As a specific example, the pointing stability requirement of the SAGE III atmospheric science instrument was examined in this paper. The instrument requires 10 arcsec stability over 2 second periods. SAGE 3 will be mounted on the ISS starboard side at the lower, outboard FIAS. In this engineering analysis, an open-loop DAC-3 finite element model of ISS was used by the Microgravity Group at Johnson Space Flight Center to generate transient responses at PAS to a limited number of disturbances. The model included dynamics up to 50 Hz. Disturbance models considered included operation of the solar array rotary joints, thermal radiator rotary joints, and control moment gyros. Responses were filtered to model the anticipated vibration attenuation effects of active control systems on the solar and thermal radiator rotary joints. A pointing stability analysis was conducted by double integrating acceleration transient over a 2 second period. Results of the analysis are tabulated for ISS X, Y, and Z Axis rotations. These results indicate that the largest excursions in rotation during pointing occurred due to rapid slewing of the thermal radiator. Even without attenuation at the rotary joints, the resulting pointing error was limited to less than 1.6 arcsec. With vibration control at the joints, to a maximum 0.5 arcsec over a 2 second period. Based on this current level of model definition, it was concluded that between 0 - 50 Hz, the pointing stability requirement for SAGE 3 will not be exceeded by the disturbances evaluated in this study.

  16. Inverting Glacial Isostatic Adjustment with Paleo Sea Level Records using Bayesian Framework and Burgers Rheology

    NASA Astrophysics Data System (ADS)

    Caron, L.; Metivier, L.; Greff-Lefftz, M.; Fleitout, L.; Rouby, H.

    2015-12-01

    Glacial Isostatic Adjustment models most often assume a mantle with a viscoelastic Maxwell rheology and a given ice history model. Here we use a Bayesian Monte Carlo with Markov Chains formalism to invert the global GIA signal simultaneously for the mechanical properties of the mantle and for the volume of the various ice-sheets using as starting ice models two distinct previously published ice histories. Burgers as well as Maxwell rheologies are considered.The fitted data consist of 5720 paleo sea level records from the last 35kyrs, with a world-wide distribution. Our ambition is to present not only the best fitting model, but also the range of possible solutions (within the explored space of parameters) with their respective probability of explaining the data, and thus reveal the trade-off effects and range of uncertainty affecting the parameters. Our a posteriori probality maps exhibit in all cases two distinct peaks: both are characterized by an upper mantle viscosity around 5.1020Pa.s but one of the peaks features a lower mantle viscosity around 3.1021Pa.s while the other indicates lower mantle viscosity of more than 1.1022Pa.s. The global maximum depends upon the starting ice history and the chosen rheology: the first peak (P1) has the highest probability only in the case with a Maxwell rheology and ice history based on ICE-5G, while the second peak (P2) is favored when using ANU-based ice history or Burgers rheology, and is our preferred solution as it is also consistent with long-term geodynamics and gravity gradients anomalies over Laurentide. P2 is associated with larger volumes for the Laurentian and Fennoscandian ice-sheets and as a consequence of total ice volume balance, smaller volumes for the Antactic ice-sheet. This last point interfers with the estimate of present-day ice-melting in Antarctica from GRACE data. Finally, we find that P2 with Burgers rheology favors the existence of a tectosphere, i.e. a viscous sublithospheric layer.

  17. Inverting Glacial Isostatic Adjustment signal using Bayesian framework and two linearly relaxing rheologies

    NASA Astrophysics Data System (ADS)

    Caron, L.; Métivier, L.; Greff-Lefftz, M.; Fleitout, L.; Rouby, H.

    2017-02-01

    Glacial Isostatic Adjustment (GIA) models commonly assume a mantle with a viscoelastic Maxwell rheology and a fixed ice history model. Here, we use a Bayesian Monte Carlo approach with a Markov Chain formalism to invert the global GIA signal simultaneously for the mechanical properties of the mantle and the volumes of the ice sheets, using as starting ice models two previously published ice histories. Two stress relaxing rheologies are considered: Burgers and Maxwell linear viscoelasticities. A total of 5720 global paleo sea levels records are used, covering the last 35kyr. Our goal is not only to seek the model best fitting this data set, but also to determine and display the range of possible solutions with their respective probability of explaining the data. In all cases our a posteriori probability maps exhibit the classic character of solutions for GIA-determined mantle viscosity with two distinct peaks. What is new in our treatment is the presence of the bi-viscous Burgers rheology and the fact that we invert rheology jointly with ice history, in combination with the greatly expanded paleo sea level records. The solutions tend to be characterized by an upper mantle viscosity of around 5 × 1020Pa.s with one preferred lower mantle viscosities at 3 × 1021Pa.s and the other more than 2 × 1022Pa.s, a rather classical pairing. Best-fitting models depend upon the starting ice history and the stress relaxing law. A first peak (P1) has the highest probability only in the case with a Maxwell rheology and ice history based on ICE-5G, while the second peak (P2) is favoured for ANU-based ice history or Burgers stress relaxation. The latter solution also may satisfy lower mantle viscosity inferences from long-term geodynamics and gravity gradient anomalies over Laurentia. P2 is also consistent with large Laurentian and Fennoscandian ice-sheet volumes at the Last Glacial Maximum (LGM) and smaller LGM Antarctic ice volume than in either ICE-5G or ANU. Exploration of a bi

  18. Ergonomic evaluation of the Apple Adjustable Keyboard

    SciTech Connect

    Tittiranonda, P.; Burastero, S.; Shih, M.; Rempel, D.

    1994-05-01

    This study presents an evaluation of the Apple Adjustable Keyboard based on subjective preference and observed joint angles during typing. Thirty five keyboard users were asked to use the Apple adjustable keyboard for 7--14 days and rate the various characteristics of the keyboard. Our findings suggest that the most preferred opening angles range from 11--20{degree}. The mean ulnar deviation on the Apple Adjustable keyboard is 11{degree}, compared to 16{degree} on the standard keyboard. The mean extension was decreased from 24{degree} to 16{degree} when using the adjustable keyboard. When asked to subjectively rate the adjustable keyboard in comparison to the standard, the average subject felt that the Apple Adjustable Keyboard was more comfortable and easier to use than the standard flat keyboard.

  19. Efficient Adjustable Reflectivity Smart Window

    SciTech Connect

    D. Morgan Tench

    2005-12-01

    This project addressed the key technical issues for development of an efficient smart window based on reversible electrochemical transfer of silver between a mirror electrode and a localized counter electrode. Effort to provide uniform switching over large areas focused on use of a resistive transparent electrode innerlayer to increase the interelectrode resistance. An effective edge seal was developed in collaboration with adhesive suppliers and an electrochromic device manufacturer. Work to provide a manufacturable counter electrode focused on fabricating a dot matrix electrode without photolithography by electrodeposition of Pt nuclei on inherent active sites on a transparent oxide conductor. An alternative counter electrode based on a conducting polymer and an ionic liquid electrolyte was also investigated. Work in all of these areas was successful. Sputtered large-bandgap oxide innerlayers sandwiched between conductive indium tin oxide (ITO) layers were shown to provide sufficient cross-layer resistance (>300 ohm/cm{sup 2}) without significantly affecting the electrochemical properties of the ITO overlayer. Two edge seal epoxies, one procured from an epoxy manufacturer and one provided by an electrochromic device manufacturer in finished seals, were shown to be effective barriers against oxygen intrusion up to 80 C. The optimum density of nuclei for the dot matrix counter electrode was attained without use of photolithography by electrodeposition from a commercial alkaline platinum plating bath. Silver loss issues for cells with dot matrix electrodes were successfully addressed by purifying the electrolyte and adjusting the cell cycling parameters. More than 30K cycles were demonstrated for a REM cell (30-cm square) with a dot matrix counter electrode. Larger cells (30-cm square) were successfully fabricated but could not be cycled since the nucleation layers (provided by an outside supplier) were defective so that mirror deposits could not be produced.

  20. Three-dimensional adjustment of trilateration data

    NASA Technical Reports Server (NTRS)

    Sung, L.-Y.; Jackson, D. D.

    1985-01-01

    The three-dimensional locations of the monuments in the USGS Hollister trilateration network were adjusted to fit line length observations observed in 1977, using a Bayesian approach, and incorporating prior elevation estimates as data in the adjustment procedure. No significant discrepancies in the measured line lengths were found, but significant elevation adjustments (up to 1.85 m) were needed to fit the length data.

  1. Multi-adjustable headband. [for headsets

    NASA Technical Reports Server (NTRS)

    Toole, Pierce C. (Inventor); Chalson, Howard E. (Inventor); Bussey, Walter S. (Inventor)

    1988-01-01

    This invention relates to a headband for a headset having separate coarse and fine adjustment features. The adjustments may be to the axial distance between at least one earpiece element and a side support. Such adjustment to the axial distance varies the pressure exerted on the head of the user. The present fine adjustment feature may be used while the headset is being worn, thereby permitting a user to optimize the amount of pressure between the contending criteria of comfort and keeping the headset in place on the user's head.

  2. Standardization of age-adjusted mortality rates

    SciTech Connect

    Selvin, S.; Sacks, S.T.; Merrill, D.W.

    1980-02-01

    Because age is a significant variable in the occurrence and frequency of human disease, any comparison of disease or mortality rates, to be useful, must be age-specific or age-adjusted. Age-specific comparisons are not always appropriate or possible, however. A common method of eliminating the influence of age in comparing mortality rates from one community to another is to employ statistical methods of age-adjustment. While a variety of methods will accomplish this task, most are weighted averages of the age-specific rates. Two widely used adjustment procedures are direct and indirect age-adjustment.

  3. Precision Adjustable Liquid Regulator (ALR)

    NASA Astrophysics Data System (ADS)

    Meinhold, R.; Parker, M.

    2004-10-01

    A passive mechanical regulator has been developed for the control of fuel or oxidizer flow to a 450N class bipropellant engine for use on commercial and interplanetary spacecraft. There are several potential benefits to the propulsion system, depending on mission requirements and spacecraft design. This system design enables more precise control of main engine mixture ratio and inlet pressure, and simplifies the pressurization system by transferring the function of main engine flow rate control from the pressurization/propellant tank assemblies, to a single component, the ALR. This design can also reduce the thermal control requirements on the propellant tanks, avoid costly Qualification testing of biprop engines for missions with more stringent requirements, and reduce the overall propulsion system mass and power usage. In order to realize these benefits, the ALR must meet stringent design requirements. The main advantage of this regulator over other units available in the market is that it can regulate about its nominal set point to within +/-0.85%, and change its regulation set point in flight +/-4% about that nominal point. The set point change is handled actively via a stepper motor driven actuator, which converts rotary into linear motion to affect the spring preload acting on the regulator. Once adjusted to a particular set point, the actuator remains in its final position unpowered, and the regulator passively maintains outlet pressure. The very precise outlet regulation pressure is possible due to new technology developed by Moog, Inc. which reduces typical regulator mechanical hysteresis to near zero. The ALR requirements specified an outlet pressure set point range from 225 to 255 psi, and equivalent water flow rates required were in the 0.17 lb/sec range. The regulation output pressure is maintained at +/-2 psi about the set point from a P (delta or differential pressure) of 20 to over 100 psid. Maximum upstream system pressure was specified at 320 psi

  4. The effect of childhood trauma on later psychological adjustment.

    PubMed

    Browne, Caroline; Winkelman, Cecelia

    2007-06-01

    This study examined whether adult attachment and cognitive distortion mediate the relationship between childhood trauma and psychological adjustment. The participants were 219 students (40 men and 117 women) enrolled in a university degree. Participants completed the Childhood Trauma Questionnaire, which assessed retrospective accounts of childhood trauma; the Relationships Scales Questionnaire, which measured two dimensions of adult attachment (model-of-self and model-of-other); the Cognitive Distortions Scale, which measured internal attributions and perceptions of controllability; and the Trauma Symptom Inventory, which assessed posttraumatic symptoms and was used in this study to measure psychological adjustment. Results supported the hypothesis that model-of-self and cognitive distortion are related constructs. The influence of model-of-self on psychological adjustment however was only via its effect on cognitive processes. In other words, a negative model-of-self influenced cognitive distortion, which in turn influenced the expression of symptoms in adults reporting a history of childhood trauma. The implications for therapy were considered.

  5. Chinese Students' Psychological and Sociocultural Adjustments to Britain: An Empirical Study

    ERIC Educational Resources Information Center

    Spencer-Oatey, Helen; Xiong, Zhaoning

    2006-01-01

    This paper reports an empirical study of the psychological and sociocultural adjustments of two cohorts of Chinese students taking a foundation course in English language at a British university. Using Zung's (1965) Self-Rating Depression Scale and a modification of Ward and Kennedy's (1999) Sociocultural Adaptation Scale, quantitative data were…

  6. Parent and Teacher Perspectives on Psychological Adjustment: A National Measurement Study in Trinidad and Tobago

    ERIC Educational Resources Information Center

    Drogalis, Anna Rhoad; McDermott, Paul A.; Watkins, Marley W.; Chao, Jessica L.; Worrell, Frank C.; Hall, Tracey E.

    2017-01-01

    This article reports on the national standardization and psychometric properties of the Adjustment Scales for Children and Adolescents--Home Edition (ASCA-H) for use in Trinidad and Tobago. ASCA-H is a parent rating scale composed of behavioral indicators in play, social, and learning contexts. The sample was comprised of students (N = 780)…

  7. Relation between Assertiveness, Academic Self-Efficacy, and Psychosocial Adjustment among International Graduate Students.

    ERIC Educational Resources Information Center

    Poyrazli, Senel; Arbona, Consuelo; Nora, Amaury; McPherson, Robert; Pisecco, Stewart

    2002-01-01

    Rathus Assertiveness Schedule, Academic Self-Efficacy Scale, The Inventory for Student Adjustment Strain, and UCLA Loneliness Scale were used to examine a total of 122 graduate international students. Findings indicate that English proficiency, assertiveness, and academic self-efficacy contributed uniquely to the variance in students' general…

  8. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  9. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  10. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  11. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  12. 49 CFR 630.11 - Data adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Data adjustments. 630.11 Section 630.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL TRANSIT DATABASE § 630.11 Data adjustments. Errors in the data used...

  13. Ergonomically Adjustable School Furniture for Male Students

    ERIC Educational Resources Information Center

    Al-Saleh, Khalid S.; Ramadan, Mohamed Z.; Al-Ashaikh, Riyad A.

    2013-01-01

    The need for adjustability in school furniture, in order to accommodate the variation in anthropometric measures of different genders, cultures and ages is becoming increasingly important. Four chair-table combinations, different in dimensions, with adjustable chair seating heights and table heights were designed, manufactured and distributed to…

  14. Adjustable, Audible Continuity Tester For Delicate Circuits

    NASA Technical Reports Server (NTRS)

    Mcalister, William B.

    1988-01-01

    Unit adjustable to resistances up to 35 ohms. Adjustable, audible electrical-continuity tester gives audible indication. Used safely on circuit boards in which semiconductor components installed, and on complementary metal oxide/semiconductor integrated circuits. Tester compact and circuit simple. Built from inexpensive standard components.

  15. Adjustably Preloaded Quick-Release Pin

    NASA Technical Reports Server (NTRS)

    Reimers, Harold W.

    1992-01-01

    Modified adjustable-grip-length quick-release pin holds two bodies together. Threaded shaft of pin threaded in floating nut to pretension fastener. Pin connects and disconnects rapidly and adjusted to accommodate small differences between thicknesses of nominally identical sets of parts to be attached to each other.

  16. 78 FR 70080 - Market Dominant Price Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... Market Dominant Price Adjustment AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The... market dominant products. The adjustments are scheduled to take effect January 26, 2014. This notice.... Ordering Paragraphs I. Overview A. Index-Based Price Changes for Market Dominant Classes of Mail...

  17. College Student Adjustment and Health Behaviors

    ERIC Educational Resources Information Center

    Hall, Lisa Anne

    2010-01-01

    This study explored the relationship between student adjustment theory and college student health behaviors. Specifically, this research examined first-year freshmen college student physical activity and nutrition behaviors and impact on adjustment to college (N = 37,564). The design for this study was a non-experimental "ex post facto"…

  18. 34 CFR 36.2 - Penalty adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Title IV of the HEA, which authorizes the Federal Family Education Loan Program $35,000. 20 U.S.C. 1094... 34 Education 1 2014-07-01 2014-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION §...

  19. 28 CFR 11.7 - Salary adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Salary adjustments. 11.7 Section 11.7 Judicial Administration DEPARTMENT OF JUSTICE DEBT COLLECTION Administration of Debt Collection § 11.7 Salary adjustments. The following debts shall not be subject to the salary offset procedures of §...

  20. 28 CFR 11.7 - Salary adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Salary adjustments. 11.7 Section 11.7 Judicial Administration DEPARTMENT OF JUSTICE DEBT COLLECTION Administration of Debt Collection § 11.7 Salary adjustments. The following debts shall not be subject to the salary offset procedures of §...

  1. 28 CFR 11.7 - Salary adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Salary adjustments. 11.7 Section 11.7 Judicial Administration DEPARTMENT OF JUSTICE DEBT COLLECTION Administration of Debt Collection § 11.7 Salary adjustments. The following debts shall not be subject to the salary offset procedures of §...

  2. 28 CFR 11.7 - Salary adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Salary adjustments. 11.7 Section 11.7 Judicial Administration DEPARTMENT OF JUSTICE DEBT COLLECTION Administration of Debt Collection § 11.7 Salary adjustments. The following debts shall not be subject to the salary offset procedures of §...

  3. 28 CFR 11.7 - Salary adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Salary adjustments. 11.7 Section 11.7 Judicial Administration DEPARTMENT OF JUSTICE DEBT COLLECTION Administration of Debt Collection § 11.7 Salary adjustments. The following debts shall not be subject to the salary offset procedures of §...

  4. 24 CFR 9.155 - Housing adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Housing adjustments. 9.155 Section 9.155 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.155 Housing adjustments. (a) The agency...

  5. 24 CFR 9.155 - Housing adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Housing adjustments. 9.155 Section 9.155 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.155 Housing adjustments. (a) The agency...

  6. 24 CFR 9.155 - Housing adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Housing adjustments. 9.155 Section 9.155 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.155 Housing adjustments. (a) The agency...

  7. 24 CFR 9.155 - Housing adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Housing adjustments. 9.155 Section 9.155 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.155 Housing adjustments. (a) The agency...

  8. 24 CFR 9.155 - Housing adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Housing adjustments. 9.155 Section 9.155 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.155 Housing adjustments. (a) The agency...

  9. Fuel injection pump with adjustable timing

    SciTech Connect

    Nakamura, H.; Abe, N.

    1987-04-28

    A fuel injection pump is described comprising: a pump body; a plunger disposed in the pump body for reciprocating within the pump body; and a pre-stroke adjusting mechanism disposed in the pump body and operatively connected with the plunger for adjusting an effective pre-stroke of the plunger.

  10. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment...-term firm power contracts only as required to respond to changes in hydrology and river...

  11. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment...-term firm power contracts only as required to respond to changes in hydrology and river...

  12. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment...-term firm power contracts only as required to respond to changes in hydrology and river...

  13. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment...-term firm power contracts only as required to respond to changes in hydrology and river...

  14. Psychological Separation and Adjustment to College.

    ERIC Educational Resources Information Center

    Lapsley, Daniel K.; And Others

    1989-01-01

    Examined relationship between psychological separation and adjustment to college in freshmen (N=130) and upperclassmen (N=123). Found freshmen showed more psychological dependencies on parents than upperclassmen; separation appeared more strongly related to personal/emotional adjustment, particularly functional and emotional independence from…

  15. Divorcing Parents: Guidelines for Promoting Children's Adjustment.

    ERIC Educational Resources Information Center

    Freeman, Kurt A.; Adams, Christina D; Drabman, Ronald S.

    1998-01-01

    There are measures that parents can take to help their children through the often distressing process of parental divorce. Describes the empirical literature regarding issues and factors relevant to children's adjustment to divorce. Provides practical guidelines and suggestions likely to help parents enhance their children's adjustment.…

  16. 7 CFR 2201.30 - Adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Adjustments. 2201.30 Section 2201.30 Agriculture Regulations of the Department of Agriculture (Continued) LOCAL TELEVISION LOAN GUARANTEE BOARD LOCAL TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS Loan Guarantees § 2201.30 Adjustments. (a) The...

  17. 7 CFR 2201.30 - Adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Adjustments. 2201.30 Section 2201.30 Agriculture Regulations of the Department of Agriculture (Continued) LOCAL TELEVISION LOAN GUARANTEE BOARD LOCAL TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS Loan Guarantees § 2201.30 Adjustments. (a) The...

  18. Does Fall History Influence Residential Adjustments?

    ERIC Educational Resources Information Center

    Leland, Natalie; Porell, Frank; Murphy, Susan L.

    2011-01-01

    Purpose of the study: To determine whether reported falls at baseline are associated with an older adult's decision to make a residential adjustment (RA) and the type of adjustment made in the subsequent 2 years. Design and Methods: Observations (n = 25,036) were from the Health and Retirement Study, a nationally representative sample of…

  19. 15 CFR 6.6 - Subsequent adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Subsequent adjustments. 6.6 Section 6.6 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION... once every four years after October 23, 1996, make the inflation adjustment, described in Section...

  20. 15 CFR 6.6 - Subsequent adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Subsequent adjustments. 6.6 Section 6.6 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION... once every four years after October 23, 1996, make the inflation adjustment, described in Section...

  1. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  2. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  3. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  4. 24 CFR 902.24 - Database adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Database adjustment. 902.24 Section 902.24 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... PUBLIC HOUSING ASSESSMENT SYSTEM Physical Condition Indicator § 902.24 Database adjustment....

  5. A Digital Game for International Students' Adjustment

    ERIC Educational Resources Information Center

    Bisadi, Maryam; Chua, Alton Y. K; Keong, Lee Chu

    2013-01-01

    Although digital games have been developed for various subject areas, little attention has been focused on using digital games to address international students' adjustment issues. For this reason, this paper endeavors to explore the use of a digital game in facilitating international students acquire adjustment-related information. Specifically,…

  6. Adjustable Optical Mount Is More Rigid

    NASA Technical Reports Server (NTRS)

    Asbury, Bill G.; Coombs, David S.; Jones, Irby W.; Moore, Alvah S., Jr.

    1994-01-01

    Improved mount for lens or mirror in laser offers rigidity similar to that of nonadjustable optical mount. In comparison with older adjustable optical mounts, this one less susceptible to movements and distortions caused by vibrations and by thermal expansions and contractions. Mount contains neither adjustment rods (which grow or shrink as temperature varies) nor springs (which transmit vibrations to mounted optic).

  7. Religiousity, Spirituality and Adolescents' Self-Adjustment

    ERIC Educational Resources Information Center

    Japar, Muhammad; Purwati

    2014-01-01

    Religiuosity, spirituality, and adolescents' self-adjustment. The objective of this study is to test the correlation among religiosity, spirituality and adolescents' self-adjustment. A quantitative approach was employed in this study. Data were collected from 476 junior high schools students of 13 State Junior High Schools and one Junior High…

  8. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 11, 2008, and before the effective date of any future inflation adjustment thereto made...

  9. 15 CFR 6.5 - Effective date of adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... INFLATION ADJUSTMENTS § 6.5 Effective date of adjustments. The adjustments made by § 6.4 of this part, of... December 11, 2008, and before the effective date of any future inflation adjustment thereto made...

  10. Man-induced channel adjustment in Tennessee streams

    USGS Publications Warehouse

    Robbins, C.H.; Simon, Andrew

    1983-01-01

    Channel modifications in Tennessee, particularly in the western part, have led to large-scale instabilities in the channelized rivers and may have contributed to several bridge failures. These modifications, together with land-use practices, led to downcutting, headward erosion, downstream aggradation, accelerated scour, and bank instabilities. Changes in gradient by channel straightening caused more severe channel response than did dredging or clearing. Large-scale changes continue to occur in all the channelized rivers: the Obion River, its forks, and the South Fork Forked Deer River. However, the non-channelized Hatchie River in west Tennessee not only withstood the natural stresses imposed by the wet years of 1973 to 1975 but continues to exhibit characteristics of stability. Water-surface slope, the primary dependent variable, proved to be a sensitive and descriptive parameter useful in determining channel adjustment. Adjustments to man-induced increases in channel-slope are described by inverse exponential functions of the basic form S=ae(-b(t)); where ' S ' is some function describing channel-slope, ' t ' is the number of years since completion of channel work, and ' a ' and ' b ' are coefficients. Response times for the attainment of ' equilibrium ' channel slopes are a function of the magnitude and extent of the imposed modifications. The adjusted profile gradients attained by the streams following channelization are similar to the predisturbed profile gradients, where no alteration to channel length was made. Where the channels were straightened by constructing cut-offs, thus shortening channel length, then slope adjustments (reduction) proceed past the predisturbed profile gradients, to new profiles with lower gradients. (USGS)

  11. Cross-Cultural Adjustment of Chinese Students in Japan: School Adjustment and Educational Support

    ERIC Educational Resources Information Center

    Li, Yuan Xiang; Sano, Hideki; Ahn, Ruth

    2013-01-01

    This study investigates Chinese immigrant students' cross-cultural and school adjustment issues in Japanese schools. Using a quantitative method, a survey which collected students' demographic information, cross-cultural adjustment, and school adjustment questions was administered to 143 Chinese junior high and high school students in Tokyo and…

  12. 49 CFR 393.53 - Automatic brake adjusters and brake adjustment indicators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... indicators. 393.53 Section 393.53 Transportation Other Regulations Relating to Transportation (Continued... brake adjustment indicators. (a) Automatic brake adjusters (hydraulic brake systems). Each commercial... vehicle at the time it was manufactured. (c) Brake adjustment indicator (air brake systems). On...

  13. 49 CFR 393.53 - Automatic brake adjusters and brake adjustment indicators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... brake adjustment indicators. (a) Automatic brake adjusters (hydraulic brake systems). Each commercial motor vehicle manufactured on or after October 20, 1993, and equipped with a hydraulic brake system, shall meet the automatic brake adjustment system requirements of Federal Motor Vehicle Safety...

  14. Assessing geomorphic sensitivity in relation to river capacity for adjustment

    NASA Astrophysics Data System (ADS)

    Reid, H. E.; Brierley, G. J.

    2015-12-01

    River sensitivity describes the nature and rate of channel adjustments. An approach to analysis of geomorphic river sensitivity outlined in this paper relates potential sensitivity based on the expected capacity of adjustment for a river type to the recent history of channel adjustment. This approach was trialled to assess low, moderate and high geomorphic sensitivity for four different types of river (10 reaches in total) along the Lower Tongariro River, North Island, New Zealand. Building upon the River Styles framework, river types were differentiated based upon valley setting (width and confinement), channel planform, geomorphic unit assemblages and bed material size. From this, the behavioural regime and potential for adjustment (type and extent) were determined. Historical maps and aerial photographs were geo-rectified and the channel planform digitised to assess channel adjustments for each reach from 1928 to 2007. Floodplain width controlled by terraces, exerted a strong influence upon reach scale sensitivity for the partly-confined, wandering, cobble-bed river. Although forced boundaries occur infrequently, the width of the active channel zone is constrained. An unconfined braided river reach directly downstream of the terrace-confined section was the most geomorphically sensitive reach. The channel in this reach adjusted recurrently to sediment inputs that were flushed through more confined, better connected upstream reaches. A meandering, sand-bed river in downstream reaches has exhibited negligible rates of channel migration. However, channel narrowing in this reach and the associated delta indicate that the system is approaching a threshold condition, beyond which channel avulsion is likely to occur. As this would trigger more rapid migration, this reach is considered to be more geomorphically sensitive than analysis of its low migration rate alone would indicate. This demonstrates how sensitivity is fashioned both by the behavioural regime of a reach

  15. Role of Osmotic Adjustment in Plant Productivity

    SciTech Connect

    Gebre, G.M.

    2001-01-11

    Successful implementation of short rotation woody crops requires that the selected species and clones be productive, drought tolerant, and pest resistant. Since water is one of the major limiting factors in poplar (Populus sp.) growth, there is little debate for the need of drought tolerant clones, except on the wettest of sites (e.g., lower Columbia River delta). Whether drought tolerance is compatible with productivity remains a debatable issue. Among the many mechanisms of drought tolerance, dehydration postponement involves the maintenance of high leaf water potential due to, for example, an adequate root system. This trait is compatible with productivity, but requires available soil moisture. When the plant leaf water potential and soil water content decline, the plant must be able to survive drought through dehydration tolerance mechanisms, such as low osmotic potential or osmotic adjustment. Osmotic adjustment and low osmotic potential are considered compatible with growth and yield because they aid in the maintenance of leaf turgor. However, it has been shown that turgor alone does not regulate cell expansion or stomatal conductance and, therefore, the role of osmotic adjustment is debated. Despite this finding, osmotic adjustment has been correlated with grain yield in agronomic crop species, and gene markers responsible for osmotic adjustment are being investigated to improve drought tolerance in productive progenies. Although osmotic adjustment and low osmotic potentials have been investigated in several forest tree species, few studies have investigated the relationship between osmotic adjustment and growth. Most of these studies have been limited to greenhouse or container-grown plants. Osmotic adjustment and rapid growth have been specifically associated in Populus and black spruce (Picea mariuna (Mill.) B.S.P.) progenies. We tested whether these relationships held under field conditions using several poplar clones. In a study of two hybrid poplar

  16. Experiment on performance of adjustable jet pump

    NASA Astrophysics Data System (ADS)

    Zhu, J. M.; Long, X. P.; Zhang, S. B.; Lu, X.

    2012-11-01

    When the water level of upper or lower reaches of hydraulic power station changes, the adjustable jet pump which is different from traditional fixed jet pump can maintain stable pressure and flow rate for the system of technical water supply of hydraulic power plant. The model test indicates that the efficiency of the adjustable jet pump is slightly lower than fixed jet pump near rating operation point. With the decrease of opening degree, both efficiencies are more and more close to each other. The fundamental performance of I-type adjustable jet pump is better than II-type and the cavitation performance of I-type adjustable jet pump is worse than II-type. Test data also indicate that the performance of adjustable jet pump is very different from fixed jet pump, so the theory of fixed jet pump is not able to be copied to adjustable jet pump. It is necessary to farther study on the performance of the adjustable jet pump. This paper has reference value for analogous design of system of circulation water supply to turbine units in hydraulic power station.

  17. Development of Adjustable Grazing Incidence Optics

    NASA Astrophysics Data System (ADS)

    Reid, Paul B.; Davis, W.; Schwartz, D. A.; Trolier-McKinstry, S.; Wilke, R. H. T.

    2010-03-01

    We report on the development of adjustable grazing incidence optics. We are developing bimorph mirrors for high resolution (sub-arc second) imaging. Bimorph mirrors consist of a thin layer of piezo-electric material deposited on the back surface of a thin (< 0.4 mm) thermally formed glass or electroplated metal segmented mirror. Voltage applied across the thickness of the piezo produces a strain in the plane of the mirror surface. The strain produces bending of the mirror similar to the bi-metallic effect. No reaction structure is necessary, which allows one to densely nest mirror shells for large effective area. A pixilated array of outer electrodes on the piezo material localizes the strain to the particular piezo "pixel.” Mirror figure errors are corrected (on-orbit) via induced localized deformations. We have successfully deposited a 1-micrometer thick layer of the piezo-electric material lead-zirconate-titanate (PZT) on thin glass mirrors. We report on the electrical and mechanical properties of the bimorph mirrors, and mirror requirements. We discuss finite element modeling of bimorph mirrors. In particular, we focus on how a difference in mirror mounting affects the influence functions ( the induced deformations). We are also developing the use of electrostrictive adjusters for moderate resolution (a few arc second) imaging. Electroplated nickel/cobalt full shells are mounted together using the adjusters. The adjusters are arrayed axially and tangentially between shells, with their adjustable dimension in the radial direction. Each shell is adjusted and fixed in place during mirror assembly, starting with the innermost shell. We review finite element modeling of the adjustable optics and the application of the adjustment system to correct manufacturing errors. We discuss initial tests using electrostrictive adjusters to change the shape of flat mirror segments. This work is supported by NASA Contract NNX09AE87G and a grant from the Gordon and Betty Moore

  18. Family expectation, social adjustment and gender differences in a sample of schizophrenic patients.

    PubMed

    Shirakawa, I; Mari, J J; Chaves, A C; Hisatsugo, M

    1996-06-01

    A case series to study factors related to family expectation regarding schizophrenic patients was conducted in an out-patient setting in the city of S. Paulo, Brazil. Patients diagnosed as presenting schizophrenia by the ICD 9th Edition and having had the disease for more than four years were included in the study. Family Expectation was measured by the difference between the Katz Adjustment Scale (R2 and R3) scores based on the relative's expectation and the socially expected activities of the patient (Discrepancy Score), and social adjustment was given by the DSM-III-R Global Assessment Scale (GAS). Outcome assessments were made independently, and 44 patients comprised the sample (25 males and 19 females). The Discrepancy mean score was twice as high for males as for females (p < 0.02), and there was an inverse relationship between the discrepancy score and social adjustment (r = -0.46, p < 0.001). Moreover, sex and social adjustment exerted independent effects on the discrepancy score when age, age at onset and number of psychiatric admissions were controlled by means of a multiple regression technique. There was an interaction between sex and social adjustment, the inverse relationship between social adjustment and discrepancy score being more pronounced for males. These findings are discussed in the light of the potential association between the family environment, gender and social adjustment of schizophrenic patients, and the need for further research, i.e. ethnographic accounts of interactions between patient and relatives sharing households particularly in less developed countries.

  19. Isolation and characterization of alpha 1-antitrypsin in PAS-positive hepatic granules from rats with experimental alpha 1-antitrypsin deficiency.

    PubMed

    Bolmer, S; Kleinerman, J

    1986-05-01

    Chronic galactosamine (GalNH2) administration in rats decreases plasma alpha 1-antitrypsin (AAT) levels to 10-50% of control levels and induces the formation of diastase-resistant, PAS-positive granules, which contain AAT in hepatocytes. This report describes the isolation and purification of hepatic granule AAT by three different methods: solubilization with guanidine hydrochloride followed by gel filtration on Bio-gel A5M, extraction with methylamine and 2-chloroethanol, and solubilization with sodium dodecyl sulfate (SDS) followed by preparative SDS-polyacrylamide gel electrophoresis. All three methods yield a single protein which precipitates with anti-rat plasma AAT antibody, and which has an apparent molecular weight of 45,000 daltons, in contrast to the molecular weight of plasma AAT, 50,000 daltons. Unlike plasma AAT, granule AAT contains no sialic acid, galactose, or fucose. Moreover, granule AAT contains a reduced amount of N-acetylglucosamine and an increased amount of mannose, compared with plasma AAT. The carbohydrate content of granule AAT varies with the isolation procedure used. Granule AAT is susceptible to cleavage by endoglucosaminidase H, which indicates the presence of high-mannose type oligosaccharides. Comparison of the molecular weight, carbohydrate composition, isoelectric point, and endoglucosaminidase H sensitivity of granule AAT isolated from rats with GalNH2-induced AAT deficiency with granule AAT from PiZ humans extends the list of similarities between experimental GalNH2-induced AAT deficiency in rats by and genetically determined AAT deficiency in humans.

  20. Tumour necrosis factor-α suppresses the hypoxic response by NF-κB-dependent induction of inhibitory PAS domain protein in PC12 cells.

    PubMed

    Goryo, Kenji; Torii, Satoru; Yasumoto, Ken-Ichi; Sogawa, Kazuhiro

    2011-09-01

    Inflammation is often accompanied by hypoxia. However, crosstalk between signalling pathways activated by inflammation and signalling events that control adaptive response to hypoxia is not fully understood. Here we show that exposure to tumour necrosis factor-α (TNF-α) activates expression of the inhibitory PAS domain protein (IPAS) to suppress the hypoxic response caused by hypoxia-inducible factor (HIF)-1 and HIF-2 in rat pheochromocytoma PC12 cells but not in human hepatoma Hep3B cells. This induction of IPAS was dependent on the nuclear factor-κB (NF-κB) pathway and attenuated hypoxic induction of HIF-1 target genes such as tyrosine hydroxylase (TH) and vascular endothelial growth factor (VEGF). HIF-dependent reporter activity in hypoxia was also decreased following TNF-α treatment. Knockdown of IPAS mRNA by small interfering RNA (siRNA) restored the TNF-α-suppressed hypoxic response. These results indicate that TNF-α is a cell-type specific suppressor of HIFs and suggest a novel crosstalk between stimulation by inflammatory mediators and HIF-dependent hypoxic response.

  1. Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila.

    PubMed

    Liu, Ying; Sheng, Zhentao; Liu, Hanhan; Wen, Di; He, Qianyu; Wang, Sheng; Shao, Wei; Jiang, Rong-Jing; An, Shiheng; Sun, Yaning; Bendena, William G; Wang, Jian; Gilbert, Lawrence I; Wilson, Thomas G; Song, Qisheng; Li, Sheng

    2009-06-01

    Juvenile hormone (JH) regulates many developmental and physiological events in insects, but its molecular mechanism remains conjectural. Here we report that genetic ablation of the corpus allatum cells of the Drosophila ring gland (the JH source) resulted in JH deficiency, pupal lethality and precocious and enhanced programmed cell death (PCD) of the larval fat body. In the fat body of the JH-deficient animals, Dronc and Drice, two caspase genes that are crucial for PCD induced by the molting hormone 20-hydroxyecdysone (20E), were significantly upregulated. These results demonstrated that JH antagonizes 20E-induced PCD by restricting the mRNA levels of Dronc and Drice. The antagonizing effect of JH on 20E-induced PCD in the fat body was further confirmed in the JH-deficient animals by 20E treatment and RNA interference of the 20E receptor EcR. Moreover, MET and GCE, the bHLH-PAS transcription factors involved in JH action, were shown to induce PCD by upregulating Dronc and Drice. In the Met- and gce-deficient animals, Dronc and Drice were downregulated, whereas in the Met-overexpression fat body, Dronc and Drice were significantly upregulated leading to precocious and enhanced PCD, and this upregulation could be suppressed by application of the JH agonist methoprene. For the first time, we demonstrate that JH counteracts MET and GCE to prevent caspase-dependent PCD in controlling fat body remodeling and larval-pupal metamorphosis in Drosophila.

  2. Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain.

    PubMed

    McGuire, J; Okamoto, K; Whitelaw, M L; Tanaka, H; Poellinger, L

    2001-11-09

    The intracellular dioxin (aryl hydrocarbon) receptor is a ligand-activated transcription factor that mediates the adaptive and toxic responses to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and structurally related congeners. Whereas the ligand-free receptor is characterized by its association with the molecular chaperone hsp90, exposure to ligand initiates a multistep activation process involving nuclear translocation, dissociation from the hsp90 complex, and dimerization with its partner protein Arnt. In this study, we have characterized a dioxin receptor deletion mutant lacking the minimal ligand-binding domain of the receptor. This mutant did not bind ligand and localized constitutively to the nucleus. However, this protein was functionally inert since it failed to dimerize with Arnt and to bind DNA. In contrast, a dioxin receptor deletion mutant lacking the minimal PAS B motif but maintaining the N-terminal half of the ligand-binding domain showed constitutive dimerization with Arnt, bound DNA, and activated transcription in a ligand-independent manner. Interestingly, this mutant showed a more potent functional activity than the dioxin-activated wild-type receptor in several different cell lines. In conclusion, the constitutively active dioxin receptor may provide an important mechanistic tool to investigate receptor-mediated regulatory pathways in closer detail.

  3. 76 FR 67500 - Postal Service Price Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... Adjustment Notice states that the overall average for Special Services is a result of large price reductions...; Address Management Services; Caller Service; Change-of-Address Credit Card Authentication; Confirm... Periodicals, Nonprofit and Classroom Periodicals, Science of Agriculture Periodicals advertising...

  4. Adjustable throttle linkage for outboard motors

    SciTech Connect

    Dunham, W.D.; Miller, G.L.

    1986-02-17

    An adjustable throttle linkage is described for use in controlling operation of an internal combustion engine having a carburetor including a pivotable throttle valve, a throttle valve position control member operably connected to the throttle valve and movable so as to control the position of the throttle valve, and a throttle lever for controlling the position of the throttle valve. The adjustable throttle linkage comprises a connecting link having one end connected to one of the throttle lever and the control member, and having a threaded portion, means for adjustably connecting the threaded portion to the other of the throttle lever and the control member. The adjustable connecting means includes a slot in the other of the throttle lever and the control member, and a rotatable member threaded onto the threaded portion and receive in the slot such that rotation of the rotatable member causes relative movement between the link and the other of the throttle lever and the control member.

  5. Floating-diffusion electrometer with adjustable sensitivity

    NASA Technical Reports Server (NTRS)

    Tower, John R. (Inventor)

    1989-01-01

    The effective capacitance of the floating diffusion in a floating-diffusion electrometer is modified to adjust electrometer sensitivity. This is done by changing the direct potential applied to a gate electrode proximate to the floating diffusion.

  6. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  7. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF...

  8. Adjustment to Divorce Through Transactional Analysis

    ERIC Educational Resources Information Center

    Morris, James D.; Prescott, Mary R.

    1976-01-01

    Transactional Analysis in a group facilitates adjustment to divorce. Two case histories highlight the value of TA in conceptualizing the problem areas of each individual and the changes during group therapy. (Author)

  9. Marital Adjustment and Psychological Distress in Japan.

    PubMed

    Li, Angela; Robustelli, Briana L; Whisman, Mark A

    2016-11-01

    This study was conducted to examine the association between marital adjustment and psychological distress in a large, probability sample of married adults in Japan (N = 710) from the Midlife Development in Japan (MIDJA) study. Results indicate that positive and negative dimensions of marital adjustment were significantly associated with dimensional and categorical measures of psychological distress. Furthermore, the associations between marital adjustment and psychological distress remained significant when statistically controlling for neuroticism, quality of friend and family relationships, and demographic variables. These results demonstrate that the well-established association between marital adjustment and psychological distress found in European-American countries is also found in Japan. Findings support continued research on marital functioning and psychological distress in East Asian countries.

  10. Siblings exposed to intimate partner violence: linking sibling relationship quality & child adjustment problems.

    PubMed

    Piotrowski, Caroline C; Tailor, Ketan; Cormier, Damien C

    2014-01-01

    Although the majority of families that experience intimate partner violence (IPV) have more than one child, most research to date has focused upon a single child within these families. A significant body of research has indicated siblings play an important role in children's adjustment and well-being. To address this gap, the three main goals of the present study were to compare the adjustment of older and younger siblings exposed to IPV, to describe and compare the quality of these sibling relationships from multiple perspectives, and to investigate how sibling adjustment and relationship quality influence children's adjustment. Forty-seven sibling pairs and their mothers were recruited from the community. Mothers self-reported on their violent experiences using the Conflict Tactics Scale, and also estimated the length of time their children were exposed to IPV. Mothers and children completed assessments of child adjustment and the quality of sibling relationships. Observers also assessed the quality of sibling interaction. Results indicated that adjustment between siblings was highly inter-related. On average, mothers reported sibling relationships as less positive but also as less hostile than did siblings themselves. Higher levels of sibling hostility, lower levels of sibling warmth and higher levels of disengagement each significantly predicted child adjustment; however, these effects were predicated upon the adjustment of the other sibling. The sibling relationships of children exposed to IPV made a difference in their individual adjustment, and their adjustment issues influenced how they feel about and interacted with their sibling. Sibling hostility played a stronger role in adjustment issues than sibling warmth. The nature of sibling influences and the direction of future research were discussed.

  11. Perceived nativeness and sensitivity to temporal adjustments in speech

    NASA Astrophysics Data System (ADS)

    Wang, Yue; Behne, Dawn M.

    2005-04-01

    Native Mandarin Chinese speakers productions of English consonant-vowel (CV) syllables have shown syllable-internal temporal adjustments in the direction of native (English)-like CVs (Wang and Behne, 2004). The current study presents two experiments investigating whether these temporal adjustments affect perceived nativeness. For three production types (native-English, Chinese productions of English, native-Chinese), three syllable-internal timing patterns (English-like, Chinese-English-like, Chinese-like) were applied, resulting in nine stimuli types. Native English listeners judged how English-like each stimulus was on a 7-point scale. In the first experiment, production-types and timing patterns were randomized. Results show that listeners can reliably identify nativeness of the three productions, with Chinese productions of English perceived as intermediate to the native Chinese and native American English productions. Listeners also showed a tendency toward using timing within the CV to identify nativeness. In the second experiment the same materials were therefore blocked by production type. Results reveal the perceptual saliency of the temporal adjustments in nonnative productions. These findings support a view of L2 acquisition as a gradual process toward the target L2 (e.g., Caramazza et al., 1973). The current study extends this view, showing evidence that listeners can perceive the inter-language system, bearing the nature of both L1 and L2.

  12. The effect of accuracy motivation on anchoring and adjustment: do people adjust from provided anchors?

    PubMed

    Simmons, Joseph P; LeBoeuf, Robyn A; Nelson, Leif D

    2010-12-01

    Increasing accuracy motivation (e.g., by providing monetary incentives for accuracy) often fails to increase adjustment away from provided anchors, a result that has led researchers to conclude that people do not effortfully adjust away from such anchors. We challenge this conclusion. First, we show that people are typically uncertain about which way to adjust from provided anchors and that this uncertainty often causes people to believe that they have initially adjusted too far away from such anchors (Studies 1a and 1b). Then, we show that although accuracy motivation fails to increase the gap between anchors and final estimates when people are uncertain about the direction of adjustment, accuracy motivation does increase anchor-estimate gaps when people are certain about the direction of adjustment, and that this is true regardless of whether the anchors are provided or self-generated (Studies 2, 3a, 3b, and 5). These results suggest that people do effortfully adjust away from provided anchors but that uncertainty about the direction of adjustment makes that adjustment harder to detect than previously assumed. This conclusion has important theoretical implications, suggesting that currently emphasized distinctions between anchor types (self-generated vs. provided) are not fundamental and that ostensibly competing theories of anchoring (selective accessibility and anchoring-and-adjustment) are complementary.

  13. Personal Adjustment Training for the Spinal Cord Injured

    ERIC Educational Resources Information Center

    Roessler, Richard; And Others

    1976-01-01

    This article describes experiences with Personal Achievement Skills (PAS), a group counseling process in a spinal cord injury project, emphasizing training in communication and goal setting in the context of group process. Issues in conducting such training and providing comprehensive service to the spinal cord injured are discussed in detail.…

  14. Mesoscale coastal behavior related to morphological self-adjustment

    NASA Astrophysics Data System (ADS)

    Cooper, J. A. G.; McKenna, J.; Jackson, D. W. T.; O'Connor, M.

    2007-02-01

    High-energy events (extratropical storms, tsunamis, and hurricanes), sediment supply variability, and sea-level rise are regarded as major drivers of coastal geomorphic behavior. In this paper we document a 170 yr record of cyclic coastal changes that occur independently of such external drivers. In a geologically constrained situation with no external sediment input, two end-member morphological configurations (attractors) are identified between which the system alternates. Although neither configuration is stable, the system as a whole exhibits century-scale equilibrium. Our findings present a hitherto unreported form of decadal scale self-adjustment in a coastal system that has occurred under a stable sea level with a consistent wave and tidal regime.

  15. Probability distribution of surface wind speed induced by convective adjustment on Venus

    NASA Astrophysics Data System (ADS)

    Yamamoto, Masaru

    2017-03-01

    The influence of convective adjustment on the spatial structure of Venusian surface wind and probability distribution of its wind speed is investigated using an idealized weather research and forecasting model. When the initially uniform wind is much weaker than the convective wind, patches of both prograde and retrograde winds with scales of a few kilometers are formed during active convective adjustment. After the active convective adjustment, because the small-scale convective cells and their related vertical momentum fluxes dissipate quickly, the large-scale (>4 km) prograde and retrograde wind patches remain on the surface and in the longitude-height cross-section. This suggests the coexistence of local prograde and retrograde flows, which may correspond to those observed by Pioneer Venus below 10 km altitude. The probability distributions of surface wind speed V during the convective adjustment have a similar form in different simulations, with a sharp peak around ∼0.1 m s-1 and a bulge developing on the flank of the probability distribution. This flank bulge is associated with the most active convection, which has a probability distribution with a peak at the wind speed 1.5-times greater than the Weibull fitting parameter c during the convective adjustment. The Weibull distribution P(> V) (= exp[-(V/c)k]) with best-estimate coefficients of Lorenz (2016) is reproduced during convective adjustments induced by a potential energy of ∼7 × 107 J m-2, which is calculated from the difference in total potential energy between initially unstable and neutral states. The maximum vertical convective heat flux magnitude is proportional to the potential energy of the convective adjustment in the experiments with the initial unstable-layer thickness altered. The present work suggests that convective adjustment is a promising process for producing the wind structure with occasionally generating surface winds of ∼1 m s-1 and retrograde wind patches.

  16. Semi-Global Matching with Self-Adjusting Penalties

    NASA Astrophysics Data System (ADS)

    Karkalou, E.; Stentoumis, C.; Karras, G.

    2017-02-01

    The demand for 3D models of various scales and precisions is strong for a wide range of applications, among which cultural heritage recording is particularly important and challenging. In this context, dense image matching is a fundamental task for processes which involve image-based reconstruction of 3D models. Despite the existence of commercial software, the need for complete and accurate results under different conditions, as well as for computational efficiency under a variety of hardware, has kept image-matching algorithms as one of the most active research topics. Semi-global matching (SGM) is among the most popular optimization algorithms due to its accuracy, computational efficiency, and simplicity. A challenging aspect in SGM implementation is the determination of smoothness constraints, i.e. penalties P1, P2 for disparity changes and discontinuities. In fact, penalty adjustment is needed for every particular stereo-pair and cost computation. In this work, a novel formulation of self-adjusting penalties is proposed: SGM penalties can be estimated solely from the statistical properties of the initial disparity space image. The proposed method of self-adjusting penalties (SGM-SAP) is evaluated using typical cost functions on stereo-pairs from the recent Middlebury dataset of interior scenes, as well as from the EPFL Herz-Jesu architectural scenes. Results are competitive against the original SGM estimates. The significant aspects of self-adjusting penalties are: (i) the time-consuming tuning process is avoided; (ii) SGM can be used in image collections with limited number of stereo-pairs; and (iii) no heuristic user intervention is needed.

  17. Testing a theoretical model for examining the relationship between family adjustment and expatriates' work adjustment.

    PubMed

    Caligiuri, P M; Hyland, M M; Joshi, A; Bross, A S

    1998-08-01

    Based on theoretical perspectives from the work/family literature, this study tested a model for examining expatriate families' adjustment while on global assignments as an antecedent to expatriates' adjustment to working in a host country. Data were collected from 110 families that had been relocated for global assignments. Longitudinal data, assessing family characteristics before the assignment and cross-cultural adjustment approximately 6 months into the assignment, were coded. This study found that family characteristics (family support, family communication, family adaptability) were related to expatriates' adjustment to working in the host country. As hypothesized, the families' cross-cultural adjustment mediated the effect of family characteristics on expatriates' host-country work adjustment.

  18. Predicting Eating Disorder Continuum Groups: Hardiness and College Adjustment.

    ERIC Educational Resources Information Center

    Simon-Boyd, Gail D.; Bieschke, Kathleen J.

    This study examined relationships between hardiness, college adjustment (academic adjustment, social adjustment, personal-emotional adjustment, institutional attachment) and eating disorder (ED) continuum categories in 122 female and 20 male college students. Students who exhibited a higher level of personal-emotional adjustment (PEA) to college…

  19. PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic cells required for the normal expression and activity of other cellular nutrient and energy sensors.

    PubMed

    Hurtado-Carneiro, Verónica; Roncero, Isabel; Blazquez, Enrique; Alvarez, Elvira; Sanz, Carmen

    2013-12-01

    PAS kinase (PASK) is a nutrient sensor that is highly conserved throughout evolution. PASK-deficient mice reveal a metabolic phenotype similar to that described in S6 kinase-1 S6K1-deficient mice that are protected against obesity. Hypothalamic metabolic sensors, such as AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR), play an important role in feeding behavior, the homeostasis of body weight, and energy balance. These sensors respond to changes in nutrient levels in the hypothalamic areas involved in feeding behavior and in neuroblastoma N2A cells, and we have recently reported that those effects are modulated by the anorexigenic peptide glucagon-like peptide-1 (GLP-1). Here, we identified PASK in both N2A cells and rat VMH and LH areas and found that its expression is regulated by glucose and GLP-1. High levels of glucose decreased Pask gene expression. Furthermore, PASK-silenced N2A cells record an impaired response by the AMPK and mTOR/S6K1 pathways to changes in glucose levels. Likewise, GLP-1 effect on the activity of AMPK, S6K1, and other intermediaries of both pathways and the regulatory role at the level of gene expression were also blocked in PASK-silenced cells. The absence of response to low glucose concentrations in PASK-silenced cells correlates with increased ATP content, low expression of mRNA coding for AMPK upstream kinase LKB1, and enhanced activation of S6K1. Our findings indicate that, at least in N2A cells, PASK is a key kinase in GLP-1 actions and exerts a coordinated response with the other metabolic sensors, suggesting that PASK might play an important role in feeding behavior.

  20. The bHLH-PAS Transcription Factor Dysfusion Regulates Tarsal Joint Formation in Response to Notch Activity during Drosophila Leg Development

    PubMed Central

    Córdoba, Sergio; Estella, Carlos

    2014-01-01

    A characteristic of all arthropods is the presence of flexible structures called joints that connect all leg segments. Drosophila legs include two types of joints: the proximal or “true” joints that are motile due to the presence of muscle attachment and the distal joints that lack musculature. These joints are not only morphologically, functionally and evolutionarily different, but also the morphogenetic program that forms them is distinct. Development of both proximal and distal joints requires Notch activity; however, it is still unknown how this pathway can control the development of such homologous although distinct structures. Here we show that the bHLH-PAS transcription factor encoded by the gene dysfusion (dys), is expressed and absolutely required for tarsal joint development while it is dispensable for proximal joints. In the presumptive tarsal joints, Dys regulates the expression of the pro-apoptotic genes reaper and head involution defective and the expression of the RhoGTPases modulators, RhoGEf2 and RhoGap71E, thus directing key morphogenetic events required for tarsal joint development. When ectopically expressed, dys is able to induce some aspects of the morphogenetic program necessary for distal joint development such as fold formation and programmed cell death. This novel Dys function depends on its obligated partner Tango to activate the transcription of target genes. We also identified a dedicated dys cis-regulatory module that regulates dys expression in the tarsal presumptive leg joints through direct Su(H) binding. All these data place dys as a key player downstream of Notch, directing distal versus proximal joint morphogenesis. PMID:25329825

  1. Enteric coating of mycophenolate reduces dosage adjustments.

    PubMed

    Brister, K; Yau, C L; Slakey, D

    2009-06-01

    Mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS) are bioequivalent. However, the effectiveness of MMF may be limited by gastrointestinal (GI) side effects. This study assessed the relationship between the number of medication dosage adjustments and posttransplantation side effects. In a review of 109 kidney transplant patients, 65 initially received MMF and 44 initially received EC-MPS. The incidences of patient-reported GI complications were significantly different: MMF 45.5% vs EC-MPS 35.3% (P = .0194). The proportions of patients requiring dosage adjustment due to GI complications were MMF 5.9% and EC-MPS 2.3% (P < .0001). Patients receiving MMF were more likely to experience GI complications resulting in dosage adjustment (odds ratio = 9.9; P = .0306). The incidences of acute rejection, cytomegalovirus (CMV), and leukopenia resulting in dosage adjustment were not significantly different. Patients receiving MMF required more immunosuppressive medication adjustments, which may complicate care and decrease overall compliance.

  2. Energetics of geostrophic adjustment in rotating flow

    NASA Astrophysics Data System (ADS)

    Fang, J.; Wu, R. S.

    2002-09-01

    Energetics of geostrophic adjustment in rotating how is examined in detail with a linear shallow water model. The Initial Unbalanced flow considered first falls under two classes. The first is similar to that adopted by Gill and is here referred to as it mass imbalance model, for the flow is initially motionless but with a sea surface displacement. The other is the same as that considered by Rossby and is referred to as I momentum imbalance model since there is only a velocity perturbation in the initial field. The significant feature of the energetics of geostrophic adjustment for the above two extreme models is that althongh the energy conversion ratio has a large case-to-case variability for different initial conditions, Its value is bounded below by 0 and above by 1 / 2. Based on the discussion of the above extreme models, the energetics of adjustment for an arbitrary initial condition is investigated. It is found that the characteristics of the energetics of geostrophic adjustment mentioned above are also applicable to adjustment of the general unbalanced flow under the condition that the energy conversion ratio is redefined as the conversion ratio between the change of kinetic energy and potential energy of the deviational fields.

  3. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  4. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  5. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  6. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  7. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small...

  8. Methods for automatic trigger threshold adjustment

    DOEpatents

    Welch, Benjamin J; Partridge, Michael E

    2014-03-18

    Methods are presented for adjusting trigger threshold values to compensate for drift in the quiescent level of a signal monitored for initiating a data recording event, thereby avoiding false triggering conditions. Initial threshold values are periodically adjusted by re-measuring the quiescent signal level, and adjusting the threshold values by an offset computation based upon the measured quiescent signal level drift. Re-computation of the trigger threshold values can be implemented on time based or counter based criteria. Additionally, a qualification width counter can be utilized to implement a requirement that a trigger threshold criterion be met a given number of times prior to initiating a data recording event, further reducing the possibility of a false triggering situation.

  9. Measurements of Glacial Isostatic Adjustment in Greenland

    NASA Astrophysics Data System (ADS)

    Khan, Shfaqat Abbas; Bamber, Jonathan; Bevis, Michael; Wahr, John; van dam, Tonie; Wouters, Bert; Willis, Michael

    2015-04-01

    The Greenland GPS network (GNET) was constructed to provide a new means to assess viscoelastic and elastic adjustments driven by past and present-day changes in ice mass. Here we assess existing glacial isostatic adjustments (GIA) models by analysing 1995-present data from 61 continuous GPS receivers located along the edge of the Greenland ice sheet. Since GPS receivers measure both the GIA and elastic signal, we isolate the GIA signal, by removing the elastic adjustments of the crust due to present-day mass loss using high-resolution ice surface elevation change grids derived from satellite and airborne altimetry measurements (ERS1/2, ICESat, ATM, ENVISAT, and CryoSat-2). In general, our observed GIA rates contradict models, suggesting GIA models and hence their ice load history for Greenland are not well constrained.

  10. Micro Ring Grating Spectrometer with Adjustable Aperture

    NASA Technical Reports Server (NTRS)

    Park, Yeonjoon (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor); Choi, Sang H. (Inventor)

    2012-01-01

    A spectrometer includes a micro-ring grating device having coaxially-aligned ring gratings for diffracting incident light onto a target focal point, a detection device for detecting light intensity, one or more actuators, and an adjustable aperture device defining a circular aperture. The aperture circumscribes a target focal point, and directs a light to the detection device. The aperture device is selectively adjustable using the actuators to select a portion of a frequency band for transmission to the detection device. A method of detecting intensity of a selected band of incident light includes directing incident light onto coaxially-aligned ring gratings of a micro-ring grating device, and diffracting the selected band onto a target focal point using the ring gratings. The method includes using an actuator to adjust an aperture device and pass a selected portion of the frequency band to a detection device for measuring the intensity of the selected portion.

  11. 75 FR 16575 - Railroad Cost Recovery Procedures-Productivity Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board. ACTION: Adoption of a railroad cost recovery procedures productivity adjustment. SUMMARY... productivity adjustment, as measured by the average change in railroad productivity for the years 2004...

  12. Psychosocial adjustment to ALS: a longitudinal study.

    PubMed

    Matuz, Tamara; Birbaumer, Niels; Hautzinger, Martin; Kübler, Andrea

    2015-01-01

    For the current study the Lazarian stress-coping theory and the appendant model of psychosocial adjustment to chronic illness and disabilities (Pakenham, 1999) has shaped the foundation for identifying determinants of adjustment to ALS. We aimed to investigate the evolution of psychosocial adjustment to ALS and to determine its long-term predictors. A longitudinal study design with four measurement time points was therefore, used to assess patients' quality of life, depression, and stress-coping model related aspects, such as illness characteristics, social support, cognitive appraisals, and coping strategies during a period of 2 years. Regression analyses revealed that 55% of the variance of severity of depressive symptoms and 47% of the variance in quality of life at T2 was accounted for by all the T1 predictor variables taken together. On the level of individual contributions, protective buffering, and appraisal of own coping potential accounted for a significant percentage in the variance in severity of depressive symptoms, whereas problem management coping strategies explained variance in quality of life scores. Illness characteristics at T2 did not explain any variance of both adjustment outcomes. Overall, the pattern of the longitudinal results indicated stable depressive symptoms and quality of life indices reflecting a successful adjustment to the disease across four measurement time points during a period of about two years. Empirical evidence is provided for the predictive value of social support, cognitive appraisals, and coping strategies, but not illness parameters such as severity and duration for adaptation to ALS. The current study contributes to a better conceptualization of adjustment, allowing us to provide evidence-based support beyond medical and physical intervention for people with ALS.

  13. Psychosocial adjustment to ALS: a longitudinal study

    PubMed Central

    Matuz, Tamara; Birbaumer, Niels; Hautzinger, Martin; Kübler, Andrea

    2015-01-01

    For the current study the Lazarian stress-coping theory and the appendant model of psychosocial adjustment to chronic illness and disabilities (Pakenham, 1999) has shaped the foundation for identifying determinants of adjustment to ALS. We aimed to investigate the evolution of psychosocial adjustment to ALS and to determine its long-term predictors. A longitudinal study design with four measurement time points was therefore, used to assess patients' quality of life, depression, and stress-coping model related aspects, such as illness characteristics, social support, cognitive appraisals, and coping strategies during a period of 2 years. Regression analyses revealed that 55% of the variance of severity of depressive symptoms and 47% of the variance in quality of life at T2 was accounted for by all the T1 predictor variables taken together. On the level of individual contributions, protective buffering, and appraisal of own coping potential accounted for a significant percentage in the variance in severity of depressive symptoms, whereas problem management coping strategies explained variance in quality of life scores. Illness characteristics at T2 did not explain any variance of both adjustment outcomes. Overall, the pattern of the longitudinal results indicated stable depressive symptoms and quality of life indices reflecting a successful adjustment to the disease across four measurement time points during a period of about two years. Empirical evidence is provided for the predictive value of social support, cognitive appraisals, and coping strategies, but not illness parameters such as severity and duration for adaptation to ALS. The current study contributes to a better conceptualization of adjustment, allowing us to provide evidence-based support beyond medical and physical intervention for people with ALS. PMID:26441696

  14. A Comparison of the Structural Factors of the Propensity for Abusiveness Scale for Women and Men in a Domestic Violence Treatment Program.

    PubMed

    Allen, Christopher T; Swan, Suzanne C; Maas, Carl D; Barber, Sara

    2015-08-01

    Court-mandated domestic violence (DV) treatment programs across the country have seen a marked increase in female clients. These programs use a variety of measurement tools to assess the needs of their clients. Increased numbers of women in treatment for DV reflect a need to address the measurement of intimate partner violence (IPV) for both males and females. Unfortunately, the reliability and validity of many of measures used to assess IPV and related constructs for women remains unknown. The current study focuses on a particular measure, the Propensity for Abusiveness Scale (PAS). The PAS is not a measure of abusive behavior per se; rather, it assesses risk factors for abuse, including affective lability, anger expression, trauma symptoms, and harsh parenting experienced by the respondent. Specifically, the current study compares the factor structure and the measurement properties of the PAS for males and females in a sample of 885 (647 female, 238 male) participants in a DV treatment program. Findings indicate that the PAS demonstrated configural, metric, and scalar invariance between the female and male samples. These results suggest that it is appropriate for researchers and clinicians to make comparisons between women and men based on PAS factor scores.

  15. The Kenyan political conflict and children's adjustment.

    PubMed

    Kithakye, Mumbe; Morris, Amanda Sheffield; Terranova, Andrew M; Myers, Sonya S

    2010-01-01

    This study examined pre- and postconflict data from 84 children, ages 3-7 years, living in Kibera, Kenya, during the December 2007 political conflict. Results indicate that children's disaster experiences (home destruction, death of a parent, parent and child harm) are associated with adjustment difficulties and that emotion regulation is an important protective factor postdisaster. Specifically, severity of the disaster experience was associated with increased aggression and decreased prosocial behavior. Emotion regulation was associated with less aggression and more prosocial behavior postconflict. Findings are discussed in the context of a developmental, systems-oriented perspective of the impact of disasters on child adjustment.

  16. Carburetion system including an adjustable throttle linkage

    SciTech Connect

    Du Bois, C.G.; Falig, J.D.

    1986-03-25

    A throttle linkage assembly is described comprising a throttle shaft rotatable about a throttle shaft axis between an idle position and a wide open throttle position, a throttle plate fixed on the throttle shaft, a driven lever pivotable about the throttle shaft axis between various angles relative to the throttle plate, and means for fixing the driven lever at a selected angle relative to the throttle plate an adjustment lever fixedly connected to the throttle adjacent the driven lever, and means for releasably securing the driven lever to the adjustment lever.

  17. Kinematic synthesis of adjustable robotic mechanisms

    NASA Astrophysics Data System (ADS)

    Chuenchom, Thatchai

    1993-01-01

    Conventional hard automation, such as a linkage-based or a cam-driven system, provides high speed capability and repeatability but not the flexibility required in many industrial applications. The conventional mechanisms, that are typically single-degree-of-freedom systems, are being increasingly replaced by multi-degree-of-freedom multi-actuators driven by logic controllers. Although this new trend in sophistication provides greatly enhanced flexibility, there are many instances where the flexibility needs are exaggerated and the associated complexity is unnecessary. Traditional mechanism-based hard automation, on the other hand, neither can fulfill multi-task requirements nor are cost-effective mainly due to lack of methods and tools to design-in flexibility. This dissertation attempts to bridge this technological gap by developing Adjustable Robotic Mechanisms (ARM's) or 'programmable mechanisms' as a middle ground between high speed hard automation and expensive serial jointed-arm robots. This research introduces the concept of adjustable robotic mechanisms towards cost-effective manufacturing automation. A generalized analytical synthesis technique has been developed to support the computational design of ARM's that lays the theoretical foundation for synthesis of adjustable mechanisms. The synthesis method developed in this dissertation, called generalized adjustable dyad and triad synthesis, advances the well-known Burmester theory in kinematics to a new level. While this method provides planar solutions, a novel patented scheme is utilized for converting prescribed three-dimensional motion specifications into sets of planar projections. This provides an analytical and a computational tool for designing adjustable mechanisms that satisfy multiple sets of three-dimensional motion specifications. Several design issues were addressed, including adjustable parameter identification, branching defect, and mechanical errors. An efficient mathematical scheme for

  18. Risk adjustment for a children's capitation rate.

    PubMed

    Newhouse, J P; Sloss, E M; Manning, W G; Keeler, E B

    1993-01-01

    Few capitation arrangements vary premiums by a child's health characteristics, yielding an incentive to discriminate against children with predictably high expenditures from chronic diseases. In this article, we explore risk adjusters for the 35 percent of the variance in annual out-patient expenditure we find to be potentially predictable. Demographic factors such as age and gender only explain 5 percent of such variance; health status measures explain 25 percent, prior use and health status measures together explain 65 to 70 percent. The profit from risk selection falls less than proportionately with improved ability to adjust for risk. Partial capitation rates may be necessary to mitigate skimming and dumping.

  19. Self-Adjusting Liquid Injectors for Combustors

    NASA Technical Reports Server (NTRS)

    Trinh, Huu; Myers, William

    2010-01-01

    A class of self-adjusting injectors for spraying liquid oxidizers and/or fuels into combustion chambers has been proposed. The proposed injectors were originally intended for use in rocket-engine combustion chambers, but could also be used to improve control over flows of liquid propellants in other combustion chambers. The basic idea of the proposed injectors is to use simple mechanisms, inside the injectors themselves, to adjust inlet areas so as to keep injection pressure drops at or near optimum values through out wide throttling ranges. These mechanisms would be actuated by the very pressure drops that they are intended to regulate.

  20. Demographic adjustments for the Spanish version of the WAIS-III.

    PubMed

    Choca, James P; Krueger, Kristin R; de la Torre, Gabriel G; Corral, S; Garside, Dan

    2009-09-01

    The Spanish version of the third edition of the Wechsler Adult Intelligence Scale (WAIS-III) by TEA Ediciones is an excellent addition to available instruments for Spanish speakers. The Spanish norms function similarly to US norms for individuals aged 16-35. The norms become increasingly different for individuals 35 and older, seemingly because of the lower levels of formal education of the older Spanish cohorts. Using data from a random half of the Spanish sample, the authors developed regression equations to adjust the scaled scores for individuals with a low level of education. The adjustment is made to the level that would have been expected if the individual had 12 years of education, the median level of education of the US norms. The article includes the methodology and values necessary to make the adjustments. The scaled scores were then adjusted for individuals on the second random half of the Spanish sample and compared to the United States norms. The results showed the adjustments succeed in bringing the Spanish norms closer to the US norms.

  1. Examining the components of children's peer liking as antecedents of school adjustment.

    PubMed

    Betts, Lucy R; Rotenberg, Ken J; Trueman, Mark; Stiller, James

    2012-06-01

    Children's social interactions with their peers influence their psychosocial adjustment; consequently, the relationship between class-wide peer liking, same-gender peer liking, and school adjustment was explored in two age groups. Peer liking was analysed using the social relations model (SRM). In Study 1, 205 children (103 female and 102 male, M(age) = 7.15, SD= 7 months) completed measures of peer liking and school adjustment, and teachers completed the Short-Form Teacher Rating Scale of School Adjustment (Short-Form TRSSA). In Study 2, 197 children (98 female and 90 male, M(age) = 9.87, SD= 5.9 months) completed measures of peer liking and school adjustment. Both studies yielded evidence of reciprocal liking and individual differences in the ratings of liking awarded to, and elicited from, both peer groups. Multigroup path analysis, with groups created according to gender, revealed that elements of liking predicted different aspects of school adjustment with some variation according to age and gender. Together, these findings suggest that the SRM can be used to examine peer liking and underscore the importance of children's peers for school adjustment.

  2. 39 CFR 3010.28 - Maximum size of unused rate adjustment authority rate adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Maximum size of unused rate adjustment authority... REGULATION OF RATES FOR MARKET DOMINANT PRODUCTS Rules for Applying the Price Cap § 3010.28 Maximum size of... of rate adjustments for any class in any 12-month period may not exceed the applicable...

  3. 39 CFR 3010.28 - Maximum size of unused rate adjustment authority rate adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Maximum size of unused rate adjustment authority... REGULATION OF RATES FOR MARKET DOMINANT PRODUCTS Rules for Applying the Price Cap § 3010.28 Maximum size of... of rate adjustments for any class in any 12-month period may not exceed the applicable...

  4. 39 CFR 3010.28 - Maximum size of unused rate adjustment authority rate adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Maximum size of unused rate adjustment authority... REGULATION OF RATES FOR MARKET DOMINANT PRODUCTS Rules for Applying the Price Cap § 3010.28 Maximum size of... of rate adjustments for any class in any 12-month period may not exceed the applicable...

  5. 5 CFR 536.305 - Adjusting an employee's retained rate when a pay schedule is adjusted.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... conversion under § 536.303(b) or any other simultaneous pay action. The retained rate adjustment under... new retained rate must be determined under the geographic conversion rule in § 536.303(b). (4... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Adjusting an employee's retained...

  6. Social desirability effects on measures of adjustment to university, independence from parents, and self-efficacy.

    PubMed

    Silverthorn, N A; Gekoski, W L

    1995-03-01

    Results of regression analyses on data from 96 first-year undergraduates indicated that social desirability (Jackson and Marlowe-Crowne Social Desirability Scales), particularly scores on the Jackson scale, is related strongly to scores on measures of adjustment (Student Adaptation to College Questionnaire), self-efficacy (Hale-Fibel Generalized Expectation for Success Scale), and independence (Psychological Separation Inventory) from mother, but not from father. In addition, both the Jackson and Marlowe-Crowne scales were correlated highly. Independence from parents and self-efficacy each continued to show a relationship with adjustment to university after social desirability effects were removed. Failure to remove the effect(s) of social desirability from the present measures is likely to lead to inflated estimates of their relation to each other or to other measures.

  7. Kinetic characterization of the WalRKSpn (VicRK) two-component system of Streptococcus pneumoniae: dependence of WalKSpn (VicK) phosphatase activity on its PAS domain.

    PubMed

    Gutu, Alina D; Wayne, Kyle J; Sham, Lok-To; Winkler, Malcolm E

    2010-05-01

    The WalRK two-component system plays important roles in maintaining cell wall homeostasis and responding to antibiotic stress in low-GC Gram-positive bacteria. In the major human pathogen, Streptococcus pneumoniae, phosphorylated WalR(Spn) (VicR) response regulator positively controls the transcription of genes encoding the essential PcsB division protein and surface virulence factors. WalR(Spn) is phosphorylated by the WalK(Spn) (VicK) histidine kinase. Little is known about the signals sensed by WalK histidine kinases. To gain information about WalK(Spn) signal transduction, we performed a kinetic characterization of the WalRK(Spn) autophosphorylation, phosphoryltransferase, and phosphatase reactions. We were unable to purify soluble full-length WalK(Spn). Consequently, these analyses were performed using two truncated versions of WalK(Spn) lacking its single transmembrane domain. The longer version (Delta35 amino acids) contained most of the HAMP domain and the PAS, DHp, and CA domains, whereas the shorter version (Delta195 amino acids) contained only the DHp and CA domains. The autophosphorylation kinetic parameters of Delta35 and Delta195 WalK(Spn) were similar [K(m)(ATP) approximately 37 microM; k(cat) approximately 0.10 min(-1)] and typical of those of other histidine kinases. The catalytic efficiency of the two versions of WalK(Spn) approximately P were also similar in the phosphoryltransfer reaction to full-length WalR(Spn). In contrast, absence of the HAMP-PAS domains significantly diminished the phosphatase activity of WalK(Spn) for WalR(Spn) approximately P. Deletion and point mutations confirmed that optimal WalK(Spn) phosphatase activity depended on the PAS domain as well as residues in the DHp domain. In addition, these WalK(Spn) DHp domain and DeltaPAS mutations led to attenuation of virulence in a murine pneumonia model.

  8. Stress and adjustment in diabetes mellitus.

    PubMed

    Parveen, S; Singh, S B

    1999-01-01

    Stress and adjustment in diabetics is studied in order to know the influence of maladjustment and stress in the causation of the disease. The sample of study consists of 100 diabetics patients, 100 nonpsychosomatic and 100 normal person. Results obtained are discussed in detail. It is concluded that maladjustment and stress are important contributing factors in' diabetes mellitus.

  9. The Kenyan Political Conflict and Children's Adjustment

    ERIC Educational Resources Information Center

    Kithakye, Mumbe; Morris, Amanda Sheffield; Terranova, Andrew M.; Myers, Sonya S.

    2010-01-01

    This study examined pre- and postconflict data from 84 children, ages 3-7 years, living in Kibera, Kenya, during the December 2007 political conflict. Results indicate that children's disaster experiences (home destruction, death of a parent, parent and child harm) are associated with adjustment difficulties and that emotion regulation is an…

  10. Self-Adjustable Adhesion of Polyampholyte Hydrogels.

    PubMed

    Roy, Chanchal Kumar; Guo, Hong Lei; Sun, Tao Lin; Ihsan, Abu Bin; Kurokawa, Takayuki; Takahata, Masakazu; Nonoyama, Takayuki; Nakajima, Tasuku; Gong, Jian Ping

    2015-12-02

    Developing nonspecific, fast, and strong adhesives that can glue hydrogels and biotissues substantially promotes the application of hydrogels as biomaterials. Inspired by the ubiquitous adhesiveness of bacteria, it is reported that neutral polyampholyte hydrogels, through their self-adjustable surface, can show rapid, strong, and reversible adhesion to charged hydrogels and biological tissues through the Coulombic interaction.

  11. 45 CFR 158.230 - Credibility adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER....230 Credibility adjustment. (a) General rule. An issuer may add to the MLR calculated under § 158.221... based on partially credible experience as defined in paragraph (c)(2) of this section. An issuer may...

  12. 45 CFR 158.230 - Credibility adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER....230 Credibility adjustment. (a) General rule. An issuer may add to the MLR calculated under § 158.221... based on partially credible experience as defined in paragraph (c)(2) of this section. An issuer may...

  13. An Unbalance Adjustment Method for Development Indicators

    ERIC Educational Resources Information Center

    Tarabusi, Enrico Casadio; Guarini, Giulio

    2013-01-01

    This paper analyzes some aggregation aspects of the procedure for constructing a composite index on a multidimensional socio-economic phenomenon such as development, the main focus being on the unbalance among individual dimensions. First a theoretical framework is set up for the unbalance adjustment of the index. Then an aggregation function is…

  14. 24 CFR 884.109 - Rent adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Rent adjustments. 884.109 Section 884.109 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... URBAN DEVELOPMENT (SECTION 8 HOUSING ASSISTANCE PROGRAMS, SECTION 202 DIRECT LOAN PROGRAM, SECTION...

  15. Effects of Maternal Depression on Youth Adjustment.

    ERIC Educational Resources Information Center

    Alexander, Jennifer

    Depressive disorders are chronic illnesses affecting women and their families for extended periods of time. This paper summarizes research related to the effects of maternal depression on children's short and long term adjustment. Children of depressed mothers are at risk for internalizing and externalizing disorders. Genetics account for a small…

  16. 24 CFR 203.411 - Cash adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Cash adjustment. 203.411 Section 203.411 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  17. 24 CFR 203.411 - Cash adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Cash adjustment. 203.411 Section 203.411 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  18. 24 CFR 203.411 - Cash adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Cash adjustment. 203.411 Section 203.411 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  19. 24 CFR 203.411 - Cash adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Cash adjustment. 203.411 Section 203.411 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  20. 24 CFR 203.411 - Cash adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Cash adjustment. 203.411 Section 203.411 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  1. 24 CFR 220.842 - Cash adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Contract Rights... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Cash adjustment. 220.842 Section 220.842 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  2. 24 CFR 220.842 - Cash adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Contract Rights... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Cash adjustment. 220.842 Section 220.842 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  3. 24 CFR 220.842 - Cash adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Contract Rights... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Cash adjustment. 220.842 Section 220.842 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  4. 24 CFR 220.842 - Cash adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Contract Rights... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Cash adjustment. 220.842 Section 220.842 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  5. 10 CFR 905.34 - Adjustment provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... continue to take place based on existing contract/marketing criteria principles. ... 10 Energy 4 2010-01-01 2010-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34...

  6. An Adjustment for Nonresponse in Sample Surveys.

    ERIC Educational Resources Information Center

    Daniel, Wayne W.; And Others

    1982-01-01

    To test the use of Bayes's theorem to adjust for nonresponse bias, 600 hospitals were used in a simulated sample survey. On the basis of known information on five variables, Bayes's formula correctly predicted the status of 92 of the 100 "nonrespondents" relative to a sixth variable. (Author/BW)

  7. 42 CFR 416.200 - Payment adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Payment adjustment. 416.200 Section 416.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... CMS as belonging to a class of new technology IOLs must submit claims using billing codes specified...

  8. 42 CFR 416.200 - Payment adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Payment adjustment. 416.200 Section 416.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... CMS as belonging to a class of new technology IOLs must submit claims using billing codes specified...

  9. Factors Mediating the Adjustment to Involuntary Childlessness.

    ERIC Educational Resources Information Center

    Sabatelli, Ronald M.; And Others

    1988-01-01

    Explored stressors that accompany experience of involuntary childlessness and examined mediators of adjustment to infertility in married individuals. Data showed deleterious effect that coping with infertility can have on couple's sexual relationship. Findings suggest important relationship between self-esteem, marital commitment, and positive…

  10. Adjustable base for centering staked bearings

    NASA Technical Reports Server (NTRS)

    Berson, L. A.

    1980-01-01

    Adjustable base permits housing and race to be supported separately so that unequal widths can be accounted for and bearing staked on center. If race is centered and staked on flat base and housing and race are not same width, then offset may occur and bearing will be set off center.

  11. 24 CFR 8.33 - Housing adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Housing adjustments. 8.33 Section 8.33 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION BASED ON HANDICAP IN FEDERALLY ASSISTED PROGRAMS AND ACTIVITIES OF THE DEPARTMENT OF HOUSING...

  12. 24 CFR 8.33 - Housing adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Housing adjustments. 8.33 Section 8.33 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION BASED ON HANDICAP IN FEDERALLY ASSISTED PROGRAMS AND ACTIVITIES OF THE DEPARTMENT OF HOUSING...

  13. 24 CFR 8.33 - Housing adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Housing adjustments. 8.33 Section 8.33 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION BASED ON HANDICAP IN FEDERALLY ASSISTED PROGRAMS AND ACTIVITIES OF THE DEPARTMENT OF HOUSING...

  14. 24 CFR 8.33 - Housing adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Housing adjustments. 8.33 Section 8.33 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION BASED ON HANDICAP IN FEDERALLY ASSISTED PROGRAMS AND ACTIVITIES OF THE DEPARTMENT OF HOUSING...

  15. 24 CFR 8.33 - Housing adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Housing adjustments. 8.33 Section 8.33 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION BASED ON HANDICAP IN FEDERALLY ASSISTED PROGRAMS AND ACTIVITIES OF THE DEPARTMENT OF HOUSING...

  16. Parenting Practices, Child Adjustment, and Family Diversity.

    ERIC Educational Resources Information Center

    Amato, Paul R.; Fowler, Frieda

    2002-01-01

    Uses data from the National Survey of Families and Households to test the generality of the links between parenting practices and child outcomes. Parents' reports of support, monitoring, and harsh punishment were associated in the expected direction with parents' reports of children's adjustment, school grades, and behavior problems, and with…

  17. Indian Family Adjustment to Children with Disabilities

    ERIC Educational Resources Information Center

    Nichols, Lee Anne; Keltner, Bette

    2005-01-01

    The purpose of this study was to explore the community response of how American Indian families adapt to having school age children with disabilities in two diverse American Indian communities. An ethnographic design was utilized to construct a taxonomy about family adjustment of American Indian families with disabilities. Community Assessment…

  18. 24 CFR 220.842 - Cash adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Contract Rights... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Cash adjustment. 220.842 Section 220.842 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  19. Social Adjustment and Personality Development in Children.

    ERIC Educational Resources Information Center

    Roff, Merrill; And Others

    This book describes a series of studies included in a 5-year program of research on the social adjustment of school children in the third through sixth grades. The sample consists of a total of 40,000 children from Texas and Minnesota, including a small subsample of 5,000 used in a 4-year longitudinal study. Peer acceptance-rejection scores…

  20. Post Separation Adjustment and Women's Liberation.

    ERIC Educational Resources Information Center

    Worthington, Elliot R.

    The interaction between post separation adjustment for reunited military families and the Women's Liberation Movement is a complex occurrence which is beginning to have a profound effect on some military families. Two forces are acting upon wives of servicemen that subject marriages to conflicts previously unheard of. One force is the critical…

  1. Social Phobia and Difficulties in Occupational Adjustment.

    ERIC Educational Resources Information Center

    Bruch, Monroe A.; Fallon, Melissa; Heimberg, Richard G.

    2003-01-01

    Examines whether social phobics differ from nonanxious controls in occupational adjustment. Results indicated that social phobics were underemployed and believed that their supervisor would rate them as less dependable. Social phobics were more anxious when starting their current job but did not differ in job satisfaction. Discusses results…

  2. On regression adjustment for the propensity score.

    PubMed

    Vansteelandt, S; Daniel, R M

    2014-10-15

    Propensity scores are widely adopted in observational research because they enable adjustment for high-dimensional confounders without requiring models for their association with the outcome of interest. The results of statistical analyses based on stratification, matching or inverse weighting by the propensity score are therefore less susceptible to model extrapolation than those based solely on outcome regression models. This is attractive because extrapolation in outcome regression models may be alarming, yet difficult to diagnose, when the exposed and unexposed individuals have very different covariate distributions. Standard regression adjustment for the propensity score forms an alternative to the aforementioned propensity score methods, but the benefits of this are less clear because it still involves modelling the outcome in addition to the propensity score. In this article, we develop novel insights into the properties of this adjustment method. We demonstrate that standard tests of the null hypothesis of no exposure effect (based on robust variance estimators), as well as particular standardised effects obtained from such adjusted regression models, are robust against misspecification of the outcome model when a propensity score model is correctly specified; they are thus not vulnerable to the aforementioned problem of extrapolation. We moreover propose efficient estimators for these standardised effects, which retain a useful causal interpretation even when the propensity score model is misspecified, provided the outcome regression model is correctly specified.

  3. Confirmatory Factor Analysis of Transfer Student Adjustment

    ERIC Educational Resources Information Center

    Young, Jacob T. N.; Litzler, Elizabeth

    2013-01-01

    Transfer students' adjustment to college has received substantial attention by researchers. This focus has predominately investigated the observation of "transfer shock": a decrease in grade point average (GPA) experienced after transferring. In response to the persistent focus on transfer shock, growing attention has been directed…

  4. 24 CFR 882.410 - Rent adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Owner is otherwise in compliance with the terms of the Lease and Contract. Subject to the foregoing... Annual Adjustment Factor by the base rents. However, if the amounts borrowed to finance the rehabilitation costs or to finance purchase of the property are subject to a variable rate or are...

  5. Domestic Violence, Emotional Competence, and Child Adjustment

    ERIC Educational Resources Information Center

    Katz, Lynn Fainsilber; Hessler, Danielle M.; Annest, Amalia

    2007-01-01

    This article examined emotion competence in children exposed to domestic violence (DV). It also examined the hypothesis that children's emotional competence mediates relations between DV and children's later difficulties with peers and behavioral adjustment. DV was assessed when children were at the age of five, emotional competence was assessed…

  6. 76 FR 7883 - Postal Service Rate Adjustment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... as a functionally equivalent agreement under the Inbound Multi-Service Agreements with Foreign Postal... Service of Type 2 Rate Adjustment, and Notice of Filing Functionally Equivalent Agreement, January 31... Foreign Postal Operators 1 product and two functionally equivalent agreements, Strategic...

  7. Loneliness and Adjustment to Old Age.

    ERIC Educational Resources Information Center

    Hansson, Robert O.; And Others

    1987-01-01

    Two studies examined loneliness in older adults (N=177). Loneliness was found to be related to poor psychological adjustment and to dissatisfaction with family and social relationships. It was also related to fears, expectations, and personality characteristics likely to inhibit the restoration of personal support networks after a stressful life…

  8. 45 CFR 1160.10 - Loss adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Loss adjustment. 1160.10 Section 1160.10 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS AND ARTIFACTS...

  9. 45 CFR 1160.10 - Loss adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Loss adjustment. 1160.10 Section 1160.10 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS AND ARTIFACTS...

  10. 45 CFR 1160.10 - Loss adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Loss adjustment. 1160.10 Section 1160.10 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS AND ARTIFACTS...

  11. 45 CFR 1160.10 - Loss adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Loss adjustment. 1160.10 Section 1160.10 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS AND ARTIFACTS...

  12. 45 CFR 1160.10 - Loss adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Loss adjustment. 1160.10 Section 1160.10 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS AND ARTIFACTS...

  13. 14 CFR Appendix - Example of SIFL Adjustment

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Example of SIFL Adjustment Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) POLICY STATEMENTS STATEMENTS OF GENERAL POLICY Policies Relating to Rates and Tariffs Treatment of deferred Federal income taxes for rate purposes. Pt. 399, Subpt....

  14. Psychological Adjustment and Academic Achievement among Adolescents

    ERIC Educational Resources Information Center

    Mahmood, Khalid; Iqbal, Muhammad Maqsood

    2015-01-01

    This study was studied that emotional and behavioural problems of young students who are directly related to their academic achievement and thus play a vital role in the development of young learners carrier. This study helped to fill a gap by conducting an exploration of psychological adjustment and academic achievement among adolescents. It also…

  15. Gender Differences in International Students' Adjustment

    ERIC Educational Resources Information Center

    Lee, Seungcheol Austin; Park, Hee Sun; Kim, Wonsun

    2009-01-01

    As gender roles in the society are being rapidly redefined, female students today are showing outstanding academic prowess and pursuing higher education. The current study recruited Korean international students (n = 76) enrolled in universities in the US and examined gender differences in academic adjustment. The findings of the current study…

  16. Psychological Adjustment in Adolescents with Vision Impairment

    ERIC Educational Resources Information Center

    Pinquart, Martin; Pfeiffer, Jens P.

    2012-01-01

    The present study compared psychological adjustment of 158 adolescents with vision impairment and 158 sighted adolescents with a matched-pair design using the Strengths and Difficulties Questionnaire. Adolescent self-reports and teacher reports on emotional problems, peer problems, and total difficulties showed higher scores in students with…

  17. Postshelter Adjustment of Children from Violent Families

    ERIC Educational Resources Information Center

    Jarvis, Kelly L.; Novaco, Raymond W.

    2006-01-01

    Few studies have examined the adjustment of battered women and their children after exiting domestic violence shelters. Participants were 62 women who had endured severe partner abuse, completed a shelter program with their children, and resided in the community for at least 6 months. Field interviews concerned mothers' and children's abuse…

  18. Rectus muscle plication using an adjustable technique

    PubMed Central

    Velez, Federico G.; Demer, Joseph L.; Pihlblad, Matthew S.; Pineles, Stacy L.

    2013-01-01

    Background Rectus muscle plication is an alternative muscle-strengthening procedure to rectus muscle resection. Possible advantages of rectus muscle plication include a lower risk of “lost” muscles and anterior segment ischemia. Methods This was a retrospective case series describing a surgical procedure for rectus muscle plication using an adjustable suture technique that can be employed on any of the four rectus muscles. Results A total of 5 adult patients underwent adjustable suture plication procedures. Of these, 2 patients required suture adjustment postoperatively. At the final follow-up visit, all of the patients maintained satisfactory ocular alignment within 6Δ of orthotropia for horizontal deviations and 2Δ of orthotropia for vertical deviations. Diplopia was eliminated in all cases with preoperative diplopia. There were no postoperative complications or unexpected shifts in ocular alignment. Conclusions Rectus muscle plication using this adjustable suture technique may serve as an alternative to rectus muscle resection and may be particularly useful in patients who are at risk for anterior segment ischemia or those in whom a shorter anesthesia time is recommended. PMID:24160967

  19. Indochinese Cross-Cultural Adjustment and Communication.

    ERIC Educational Resources Information Center

    Nguyen, Liem Dang

    Information is given about the cultural and religious background of Indochinese refugees arriving in the United States since 1975, to be used as a basis for promoting cross-cultural adjustment and communication with and in this group. The Indochinese exodus since 1975 is briefly described, focusing on the journey undertaken and the spread of…

  20. Sex Role Identity and Adjustment during Adolescence.

    ERIC Educational Resources Information Center

    Massad, Christopher M.

    1981-01-01

    Examined the relationship between sex role identity and two measures of adjustment--self-acceptance and peer acceptance--among adolescents. Sex differences were discovered regarding factors positively associated with self-acceptance. Findings suggest that a model of sex role differentiation during adolescence must recognize differential pressures…

  1. Frequency adjustable MEMS vibration energy harvester

    NASA Astrophysics Data System (ADS)

    Podder, P.; Constantinou, P.; Amann, A.; Roy, S.

    2016-10-01

    Ambient mechanical vibrations offer an attractive solution for powering the wireless sensor nodes of the emerging “Internet-of-Things”. However, the wide-ranging variability of the ambient vibration frequencies pose a significant challenge to the efficient transduction of vibration into usable electrical energy. This work reports the development of a MEMS electromagnetic vibration energy harvester where the resonance frequency of the oscillator can be adjusted or tuned to adapt to the ambient vibrational frequency. Micro-fabricated silicon spring and double layer planar micro-coils along with sintered NdFeB micro-magnets are used to construct the electromagnetic transduction mechanism. Furthermore, another NdFeB magnet is adjustably assembled to induce variable magnetic interaction with the transducing magnet, leading to significant change in the spring stiffness and resonance frequency. Finite element analysis and numerical simulations exhibit substantial frequency tuning range (25% of natural resonance frequency) by appropriate adjustment of the repulsive magnetic interaction between the tuning and transducing magnet pair. This demonstrated method of frequency adjustment or tuning have potential applications in other MEMS vibration energy harvesters and micromechanical oscillators.

  2. Trajectories of adjustment to couple relationship separation.

    PubMed

    Halford, W Kim; Sweeper, Susie

    2013-06-01

    To test a stress-diathesis model of adjustment to separation, the current study describes the trajectories of different aspects of separation adjustment in people formerly married or cohabiting, and moderators of those trajectories. A convenience sample of 303 recently separated individuals (169 women; 134 men) completed assessments of their emotional attachment to the former partner, loneliness, psychological distress, and coparenting conflict at two time points 6 months apart. Multilevel modeling of the overlapping multicohort design was used to estimate the trajectories of these different aspects of adjustment as a function of time since separation, marital status, gender, presence of children from the relationship, who initiated separation, social support, and anxious attachment. Attachment to the former partner, loneliness, and psychological distress were initially high but improved markedly across the 2 years after separation, but coparenting conflict was high and stable. Adjustment problems were similar in men and women, and in those formerly married or cohabiting, except that reported coparenting conflict was higher in men than women. Low social support and high anxious attachment predicted persistent attachment to the former partner, loneliness, and psychological distress. Coparenting conflict is a common, chronic problem for many separated individuals, and individuals with certain psychological vulnerabilities also experience chronic personal distress.

  3. Psychological adjustment to twins after infertility.

    PubMed

    Klock, Susan C

    2004-08-01

    The birth of twins and other multiples is physically and emotionally stressful. The increase in the use of the assisted reproductive technologies has lead to an exponential increase in the rates of twins and triplets in the US. Whereas the medical complications of twins and other multiples has been well studied, the psychological and social implications of these events has not. Very little empirical research has been conducted to assess the differential impact of twins, as compared to singletons, on maternal adjustment, postpartum depression and marital functioning. In addition, assessment of infant health, disposition and behavior and its relation to maternal adjustment is lacking. The birth of twins after a period of infertility complicates the clinical picture and the impact of infertility on subsequent parental adjustment is only beginning to be understood. Although research suggests that infertile couples often desire multiples, the experience of parenting multiples after infertility has not been studied. Research on fertile couples indicate that: (i) approximately 10% of women develop postpartum depression and; (ii) marital adjustment declines after the birth of the first child. Because of the unique demands of parenting multiples, it is hypothesized that mothers of twins who have a history of infertility would be at increased risk for depression and marital decline. Descriptive studies of these families support this view, although additional studies are needed to determine the degree and extent of the problem. Additionally, variables such as, prepregnancy adjustment, equitable division of child-care tasks and perceived social support should be studied to determine if they buffer against the expected effects.

  4. Perceived Social Acceptance, Theory of Mind and Social Adjustment in Children with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Fiasse, Catherine; Nader-Grosbois, Nathalie

    2012-01-01

    Perceived social acceptance, theory of mind (ToM) and social adjustment were investigated in 45 children with intellectual disabilities (ID) compared with 45 typically developing (TD) preschoolers, matched for developmental age assessed by means of the Differential Scales of Intellectual Efficiency-Revised edition (EDEI-R, Perron-Borelli, 1996).…

  5. Impact of Interpersonal Problem-Solving Training on Preschooler's Behavioral Adjustment.

    ERIC Educational Resources Information Center

    Sharp, Kay Colby

    The relationship between interpersonal problem-solving training and behavioral adjustment was examined for 54 black, low-income preschool children. Pre- and post-testing was done with two interpersonal problem-solving measures designed by Shure and Spivack, Shure and Spivack's Hahnemann Preschool Behavior Rating Scale which classroom teachers were…

  6. Sonde Adjust Value-Added Product Technical Report

    SciTech Connect

    Troyan, D

    2012-01-09

    The Sonde Adjust (SONDEADJUST) value-added product (VAP) creates a file that includes all fields from original Atmospheric Radiation Measurement Climate Research Facility (ARM Facility) radiosonde files and contains several value-added fields that provide adjustments related to well-known humidity issues. SONDEADJUST produces data that correct documented biases in radiosonde humidity measurements. Previous efforts towards applying some of these corrections are available via the discontinued PI product sgpsondecorr1miloC1. Unique fields contained within this datastream include smoothed original relative humidity, dry bias corrected relative humidity, and final corrected relative humidity. The smoothed RH field refines the relative humidity from integers-the resolution of the instrument-to fractions of a percent. This profile is then used to calculate the dry bias corrected field. The final correction fixes the time-lag problem and uses the dry-bias field as input into the algorithm. In addition to dry bias, solar heating is another correction that is encompassed in the final corrected RH field. Output from SONDEADJUST differs from the previous RH-corrected datastreams in important ways. First, all three types of ARM radiosondes-Vaisala RS-80, RS-90, and RS-92-are corrected using dedicated procedures and/or parameters. Second, the output variables include all of those found in the original radiosonde file: dry bulb temperature, dewpoint temperature, wind speed, wind direction, eastward wind component, northward wind component, wind status (a Vaisala-produced field used in conjunction with the Loran system), ascent rate, and original relative humidity. Additional humidity fields are smoothed relative humidity, dry biased corrected relative humidity, final ambient relative humidity, and scaled adjusted relative humidity. Third, quality control (QC) flags of the fields from the original radiosonde datastream are brought into the SONDEADJUST output file. Additional QC

  7. One-Year Outcomes in "Real-World" Patients Treated With a Thin-Strut, Platinum-Chromium, Everolimus-Eluting Stent (from the PROMUS Element Plus US Post-Approval Study [PE-Plus PAS]).

    PubMed

    Kandzari, David E; Amjadi, Nima; Caputo, Christopher; Rowe, Steven K; Williams, Jerome; Tamboli, Hoshedar P; Christen, Thomas; Allocco, Dominic J; Dawkins, Keith D

    2016-02-15

    The PROMUS Element Plus US Post-Approval Study (PE-Plus PAS) was a prospective, open-label, multicenter, observational study designed to examine outcomes in everyday clinical practice in patients treated with everolimus-eluting, platinum-chromium PROMUS Element Plus stents at 52 centers in the United States. This is the first report of results from this large study. The primary end point of the PE-Plus PAS was 12-month cardiac death or myocardial infarction in the more restricted population of "PLATINUM-like" patients pooled from the PE-Plus PAS, PE-PROVE (PROMUS Element European post-approval study), and PLATINUM Workhorse/Small Vessel trials. Additional clinical end points were tested in the overall PE-Plus PAS patient population. Of the 2,683 patients enrolled in PE-Plus PAS, 70% were men, mean age was 64 years, 33% had diabetes, and 29% were "PLATINUM-like." Among the PLATINUM-like patients, 12-month cardiac death or myocardial infarction was 1.8% (33 of 1,855) with an upper 1-sided 95% confidence interval of 2.3%, which was significantly less than the prespecified performance goal of 3.2% (pnoninferiority <0.001). In the overall PE-Plus population, 12-month target vessel failure (defined as death, MI, or revascularization related to the target vessel) was 6.7% (170 of 2,554), cardiac death was 1.4% (37 of 2,554), MI was 1.1% (28 of 2,554), and ARC-definite/probable stent thrombosis was 0.7% (19 of 2,554). A prespecified secondary end point of 12-month target vessel failure in diabetic patients demonstrated a rate of 4.2% (14 of 332) with an upper 1-sided 95% confidence interval of 6.03%, which was significantly less than the performance goal of 12.6% (pnoninferiority <0.001). In conclusion, in this large registry of unselected patients, coronary artery revascularization with the PROMUS Element Plus everolimus-eluting stent demonstrates favorable results with low 1-year clinical event rates.

  8. Geophysical Constraints on Mantle Viscosity and its Influence on Antarctic Glacial Isostatic Adjustment

    NASA Astrophysics Data System (ADS)

    Darlington, Andrea

    Glacial isostatic adjustment (GIA) is the process by which the solid Earth responds to past and present-day changes in glaciers, ice caps, and ice sheets. This thesis focuses on vertical crustal motion of the Earth caused by GIA, which is influenced by several factors including lithosphere thickness, mantle viscosity profile, and changes to the thickness and extent of surface ice. The viscosity of the mantle beneath Antarctica is a poorly constrained quantity due to the rarity of relative sea-level and heat flow observations. Other methods for obtaining a better-constrained mantle viscosity model must be investigated to obtain more accurate GIA model predictions. The first section of this study uses seismic wave tomography to determine mantle viscosity. By calculating the deviation of the P- and S-wave velocities relative to a reference Earth model (PREM), the viscosity can be determined. For Antarctica mantle viscosities obtained from S20A (Ekstrom and Dziewonski, 1998) seismic tomography in the asthenosphere range from 1016 Pa˙s to 1023 Pa˙s, with smaller viscosities beneath West Antarctica and higher viscosities beneath East Antarctica. This agrees with viscosity expectations based on findings from the Basin and Range area of North America, which is an analogue to the West Antarctic Rift System. Section two compares bedrock elevations in Antarctica to crustal thicknesses, to infer mantle temperatures and draw conclusions about mantle viscosity. Data from CRUST 2.0 (Bassin et al., 2000), BEDMAP (Lythe and Vaughan, 2001) and specific studies of crustal thickness in Antarctica were examined. It was found that the regions of Antarctica that are expected to have low viscosities agree with the hot mantle trend found by Hyndman (2010) while the regions expected to have high viscosity are in better agreement with the trend for cold mantle. Bevis et al. (2009) described new GPS observations of crustal uplift in Antarctica and compared the results to GIA model

  9. 26 CFR 1.737-3 - Basis adjustments; Recovery rules.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Basis adjustments; Recovery rules. 1.737-3...; Recovery rules. (a) Distributee partner's adjusted tax basis in the partnership interest. The distributee...) Recovery of increase to adjusted tax basis. Any increase to the adjusted tax basis of partnership...

  10. 26 CFR 1.737-3 - Basis adjustments; Recovery rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Basis adjustments; Recovery rules. 1.737-3... TAX (CONTINUED) INCOME TAXES Distributions by A Partnership § 1.737-3 Basis adjustments; Recovery...) Recovery of increase to adjusted tax basis. Any increase to the adjusted tax basis of partnership...

  11. A Comparative Study of the Adjustment of Secondary School Students

    ERIC Educational Resources Information Center

    Devika R.

    2014-01-01

    Education is the ability to meet one's life. How the child adjusts with varying situations determines the success of life. The child's adjustment is determined by a number of factors like Home, Social, Educational and Financial adjustment. The investigator here aims to make a comparative study on the adjustment of secondary school students. The…

  12. 7 CFR 3.91 - Adjusted civil monetary penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Adjusted civil monetary penalties. 3.91 Section 3.91 Agriculture Office of the Secretary of Agriculture DEBT MANAGEMENT Adjusted Civil Monetary Penalties § 3.91 Adjusted civil monetary penalties. (a) In general. (1) The Secretary will adjust the civil...

  13. 50 CFR 648.321 - Framework adjustment process.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Framework adjustment process. 648.321... Measures for the NE Skate Complex Fisheries § 648.321 Framework adjustment process. (a) Adjustment process. To implement a framework adjustment for the Skate FMP, the Council shall develop and analyze...

  14. 50 CFR 648.321 - Framework adjustment process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Framework adjustment process. 648.321... Measures for the NE Skate Complex Fisheries § 648.321 Framework adjustment process. (a) Adjustment process. To implement a framework adjustment for the Skate FMP, the Council shall develop and analyze...

  15. 50 CFR 648.321 - Framework adjustment process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Framework adjustment process. 648.321... Measures for the NE Skate Complex Fisheries § 648.321 Framework adjustment process. (a) Adjustment process. To implement a framework adjustment for the Skate FMP, the Council shall develop and analyze...

  16. 78 FR 59093 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... quarter. In Railroad Cost Recovery Procedures--Productivity Adjustment, 5 I.C.C. 2d 434 (1989), aff'd sub... require the adjustment of the quarterly index for a measure of productivity. The provisions of 49 U.S.C... a productivity-adjusted RCAF. In Productivity Adjustment--Implementation, 1 S.T.B. 739 (1996),...

  17. 28 CFR 85.2 - Calculation of adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Inflation Adjustment Act of 1990, Pub. L. 101-410. Any increase so determined was rounded to the nearest— (1... 85.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CIVIL MONETARY PENALTIES INFLATION ADJUSTMENT § 85.2 Calculation of adjustment. (a) The inflation adjustments described in § 85.3...

  18. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not exceed ten percent (10%) of the respective...

  19. 15 CFR 6.3 - Limitation on First Adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Limitation on First Adjustments. 6.3 Section 6.3 Commerce and Foreign Trade Office of the Secretary of Commerce CIVIL MONETARY PENALTY INFLATION ADJUSTMENTS § 6.3 Limitation on First Adjustments. Each of the First Adjustments may not...

  20. 12 CFR 263.65 - Civil penalty inflation adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Civil penalty inflation adjustments. 263.65... Money Penalties § 263.65 Civil penalty inflation adjustments. (a) Inflation adjustments. In accordance with the Federal Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note), the Board...