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Sample records for adm service building

  1. ADM. Administration Building (TAN602). Elevations, sections, details. Shows areas that ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ADM. Administration Building (TAN-602). Elevations, sections, details. Shows areas that were soon remodeled or added onto. Ralph M. Parsons 902-2-ANP-602-A 32 Date: August 1955. Approved by INEEL Classification Office for public release. INEEL index code no. 033-0602-00-693-106711 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  2. ADM. Aerial view of administration area. Camera facing westerly. From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ADM. Aerial view of administration area. Camera facing westerly. From left to right in foregound: Substation (TAN-605), Warehouse (TAN-628), Gate House (TAN-601), Administration Building (TAN-602). Left to right middle ground: Service Building (TAN-603), Warehouse (later known as Maintenance Shop or Craft Shop, TAN-604), Water Well Pump Houses, Fuel Tanks and Fuel Pump Houses, and Water Storage Tanks. Change House (TAN-606) on near side of berm. Large building beyond berm is A&M. Building, TAN-607. Railroad tracks beyond lead from (unseen) turntable to the IET. Date: June 6, 1955. INEEL negative no. 13201 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  3. ADME studies of [5-(3)H]-2'-O-methyluridine nucleoside in mice: a building block in siRNA therapeutics.

    PubMed

    Lozac'h, Frederic; Christensen, Jesper; Faller, Thomas; van de Kerkhof, Esther; Krauser, Joel; Garnier, Maxime; Litherland, Karine; Catoire, Alexandre; Natt, Francois; Hunziker, Jurg; Swart, Piet

    2016-02-01

    The chemical modification 2'-O-methyl of nucleosides is often used to increase siRNA stability towards nuclease activities. However, the metabolic fate of modified nucleosides remains unclear. Therefore, the aim of this study was to determine the mass balance, pharmacokinetic, and absorption, distribution, metabolism, and excretion (ADME)-properties of tritium-labeled 2'-O-methyluridine, following a single intravenous dose to male CD-1 mice. The single intravenous administration of [5-(3)H]-2'-O-methyluridine was well tolerated in mice. Radioactivity was rapidly and widely distributed throughout the body and remained detectable in all tissues investigated throughout the observation period of 48 h. After an initial rapid decline, blood concentrations of total radiolabeled components declined at a much slower rate. [(3)H]-2'-O-Methyluridine represented a minor component of the radioactivity in plasma (5.89% of [(3)H]-AUC 0-48 h). Three [(3)H]-2'-O-methyluridine metabolites namely uridine (M1), cytidine (M2), and uracil (M3) were the major circulating components representing 32.8%, 8.11%, and 23.6% of radioactivity area under the curve, respectively. The highest concentrations of total radiolabeled components and exposures were observed in kidney, spleen, pineal body, and lymph nodes. The mass balance, which is the sum of external recovery of radioactivity in excreta and remaining radioactivity in carcass and cage wash, was complete. Renal excretion accounted for about 52.7% of the dose with direct renal excretion of the parent in combination with metabolism to the endogenous compounds cytidine, uracil, cytosine, and cytidine. PMID:26977299

  4. Supporting Theory Building in Integrated Services Research

    ERIC Educational Resources Information Center

    Robinson, Mark; Atkinson, Mary; Downing, Dick

    2008-01-01

    This literature review was commissioned by the National Foundation for Educational Research (NFER) to draw together current and recent studies of integrated working, in order to build an overview of the theories and models of such working. The review is important for current work on evaluating the early impact of integrated children's services and…

  5. Building Resilience in Pre-Service Teachers

    ERIC Educational Resources Information Center

    Le Cornu, Rosie

    2009-01-01

    This article examines the role that professional experiences (practicum) can play in building resilience in pre-service teachers. In particular it focuses on a learning communities model of professional experience with its emphasis on relationships and its attention to the complex and dynamic interactions between individuals and their "student…

  6. Service building no. 620. Details of ramps in south end ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Service building no. 620. Details of ramps in south end of service building (Dry Dock Associates, November 7, 1941). In files of Cushman & Wakefiled, building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

  7. 22. Perimeter acquisition radar building room #201, phase shifter service ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Perimeter acquisition radar building room #201, phase shifter service platform (level two) - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  8. 36. Perimeter acquisition radar building, phase shifter service platform; level ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. Perimeter acquisition radar building, phase shifter service platform; level three - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  9. Service building. Cross section thru dry dock nos. 4 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Service building. Cross section thru dry dock nos. 4 & 5 showing service bldg & 20-75-150 ton cranes (dry dock associates, May 23, 1941). In files of Cushman & Wakefield, building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

  10. Dry dock no. 4. Service Building between dry docks 4 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Dry dock no. 4. Service Building between dry docks 4 and 5. Floor plans (Navy Yard Public Works Office 1941). In files of Cushman & Wakefield, building 501. Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

  11. Ford Service Building in foreground with new facade covering front ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Ford Service Building in foreground with new facade covering front elevation. Original facade can be seen on side. Original was eight-story reinforced concrete Albert Kahn design with exposed structural frame. One-story addition on north side. Stone veneer covers south and west facades of the building in strips - Ford Service Building, 7310 Woodward Avenue, Detroit, MI

  12. REACTOR SERVICE BUILDING, TRA635. CAMERA FACING NORTHWEST. BUILDING PROJECTS FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICE BUILDING, TRA-635. CAMERA FACING NORTHWEST. BUILDING PROJECTS FROM AND CONNECTS TO SOUTH WALL OF MTR BUILDING. EARTH BERM SHIELDING PLUG STORAGE BUILDING IS AT RIGHT OF VIEW. INL NEGATIVE NO. 9913. Unknown Photographer, 2/23/1954 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  13. 37. Perimeter acquisition radar building, phase shifter service platform, level ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Perimeter acquisition radar building, phase shifter service platform, level three; This shows the coaxial switches and transmitter output assembly (located only on this level) - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  14. Building a Radiology Service Line: Key Elements and Necessary Actions.

    PubMed

    Hawkins, C Matthew

    2016-01-01

    Building a radiology service line is a challenge. Beyond the science of imaging and pathophysiology of disease, there are a number of key elements and necessary actions-related to personnel, communication, and resources-that must be taken to make the service line successful and sustainable. Although there is no single best way to build an imaging-based service line, there are a number of essential components. The purpose of this article is to delineate these components and describe how ambitious radiologists may successfully build and sustain a radiology service line. PMID:26476845

  15. Quality Management and Building Government Information Services.

    ERIC Educational Resources Information Center

    Farrell, Maggie

    1998-01-01

    Discusses serving library-patron needs in terms of customer service and quality control. Highlights include tools for measuring the quality of service (e.g., the SERVQUAL survey), advisory boards or focus groups, library "service statements," changing patron needs, new information formats, and justifying depository library services. (JAK)

  16. Estimation of ADME properties with substructure pattern recognition.

    PubMed

    Shen, Jie; Cheng, Feixiong; Xu, You; Li, Weihua; Tang, Yun

    2010-06-28

    Over the past decade, absorption, distribution, metabolism, and excretion (ADME) property evaluation has become one of the most important issues in the process of drug discovery and development. Since in vivo and in vitro evaluations are costly and laborious, in silico techniques had been widely used to estimate ADME properties of chemical compounds. Traditional prediction methods usually try to build a functional relationship between a set of molecular descriptors and a given ADME property. Although traditional methods have been successfully used in many cases, the accuracy and efficiency of molecular descriptors must be concerned. Herein, we report a new classification method based on substructure pattern recognition, in which each molecule is represented as a substructure pattern fingerprint based on a predefined substructure dictionary, and then a support vector machine (SVM) algorithm is applied to build the prediction model. Therefore, a direct connection between substructures and molecular properties is built. The most important substructure patterns can be identified via the information gain analysis, which could help to interpret the models from a medicinal chemistry perspective. Afterward, this method was verified with two data sets, one for blood-brain barrier (BBB) penetration and the other for human intestinal absorption (HIA). The results demonstrated that the overall predictive accuracies of the best HIA model for the training and test sets were 98.5 and 98.8%, and the overall predictive accuracies of the best BBB model for the training and test sets were 98.8 and 98.4%, which confirmed the reliability of our method. In the additional validations, the predictive accuracies were 94 and 69.5% for the HIA and the BBB models, respectively. Moreover, some of the representative key substructure patterns which significantly correlated with the HIA and BBB penetration properties were also presented. PMID:20578727

  17. On Equilibria for ADM Minimization Games

    NASA Astrophysics Data System (ADS)

    Epstein, Leah; Levin, Asaf

    In the ADM minimization problem, the input is a set of arcs along a directed ring. The input arcs need to be partitioned into non-overlapping chains and cycles so as to minimize the total number of endpoints, where a k-arc cycle contributes k endpoints and a k-arc chain contains k + 1 endpoints. We study ADM minimization problem both as a non-cooperative and a cooperative games. In these games, each arc corresponds to a player, and the players share the cost of the ADM switches. We consider two cost allocation models, a model which was considered by Flammini et al., and a new cost allocation model, which is inspired by congestion games. We compare the price of anarchy and price of stability in the two cost allocation models, as well as the strong price of anarchy and the strong price of stability.

  18. 39. View of north side of 1958 service building, north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. View of north side of 1958 service building, north side of warehouse, and north and west sides of parking deck, from northwest on Spring Street viaduct looking southeast. - Rich's Downtown Department Store, 45 Broad Street, Atlanta, Fulton County, GA

  19. 2. Historic American Buildings Survey, National Park Service, San Francisco ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, National Park Service, San Francisco Re-photo: May 1940 - Miners' Union Hall, West side B Street, between Union & Sutton Streets, Virginia City, Storey County, NV

  20. 2. Historic American Buildings Survey National Park Service San Francisco, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey National Park Service San Francisco, California Year Built: 1835 Photo Taken: 1939 GENERAL VIEW - Pacific House, 200-222 Calle Principal, Monterey, Monterey County, CA

  1. Building Bridges: Supporting Families across Service Systems.

    ERIC Educational Resources Information Center

    Goetz, Kathy, Ed.

    1994-01-01

    This double issue of the journal "Report" focuses on the collaboration among seven social service systems that support and serve children and families. Each of the sections discusses one of the seven systems, presents an overview essay, and profiles programs that execute the service. The first section, on education, emphasizes linkages between…

  2. CCC CAMP WICKIUP – OFFICE BUILDING, CENTER; TECHNICAL SERVICE QUARTERS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CCC CAMP WICKIUP – OFFICE BUILDING, CENTER; TECHNICAL SERVICE QUARTERS, RIGHT; EDUCATIONAL BUILDING, LEFT. Photocopy of historic photographs (original photograph on file at National Archives, Rocky Mountain Region, Denver, CO). Unknown USBR Photographer, December 9, 1938 - Wickiup Dam, Deschutes River, La Pine, Deschutes County, OR

  3. 7. Interior view, industrial service building, showing east wall with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Interior view, industrial service building, showing east wall with large switch box connected to conduits buried in concrete floor, they were connected to breaker panels in center of building. - Charlestown Navy Yard, Pier 11, Charlestown Waterfront at confluence of Little Mystic Channel & Mystic River at northernmost ent of Navy Yard, Boston, Suffolk County, MA

  4. The Public Library Building and Information Services.

    ERIC Educational Resources Information Center

    McCabe, Gerard B.

    A library building consultant discusses ways in which public libraries can plan for the participation of their libraries in the National Information Infrastructure (NII). With participants ranging from schools to agencies of local government, large volumes of information will be passing through the NII network. Public libraries will be engaged in…

  5. ETRMTR MECHANICAL SERVICES BUILDING, TRA653. CAMERA FACING NORTHWEST AS BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR-MTR MECHANICAL SERVICES BUILDING, TRA-653. CAMERA FACING NORTHWEST AS BUILDING WAS NEARLY COMPLETE. INL NEGATIVE NO. 57-3653. K. Mansfield, Photographer, 7/22/1957 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  6. LOFT. Containment building (TAN650) detail. Camera facing east. Service building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOFT. Containment building (TAN-650) detail. Camera facing east. Service building corner is at left of view above personnel access. Round feature at left of dome is tank that will contain borated water. Metal stack at right of view. Date: 1973. INEEL negative no. 73-1085 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  7. Strategic approaches to optimizing peptide ADME properties.

    PubMed

    Di, Li

    2015-01-01

    Development of peptide drugs is challenging but also quite rewarding. Five blockbuster peptide drugs are currently on the market, and six new peptides received first marketing approval as new molecular entities in 2012. Although peptides only represent 2% of the drug market, the market is growing twice as quickly and might soon occupy a larger niche. Natural peptides typically have poor absorption, distribution, metabolism, and excretion (ADME) properties with rapid clearance, short half-life, low permeability, and sometimes low solubility. Strategies have been developed to improve peptide drugability through enhancing permeability, reducing proteolysis and renal clearance, and prolonging half-life. In vivo, in vitro, and in silico tools are available to evaluate ADME properties of peptides, and structural modification strategies are in place to improve peptide developability. PMID:25366889

  8. Sequestering ADM ethanol plant carbon dioxide

    USGS Publications Warehouse

    Finley, R.J.; Riddle, D.

    2008-01-01

    Archer Daniels Midland Co. (ADM) and the Illinois State Geological Survey (ISGS) are collaborating on a project in confirming that a rock formation can store carbon dioxide from the plant in its pores. The project aimed to sequester the gas underground permanently to minimize release of the greenhouse gas into the atmosphere. It is also designed to store one million tons of carbon dioxide over a three-year period. The project is worth $84.3M, funded by $66.7M from the US Department Energy, supplemented by co-funding from ADM and other corporate and state resources. The project will start drilling of wells to an expected depth over 6500 feet into the Mount Simon Sandstone formation.

  9. Duality, entropy, and ADM mass in supergravity

    SciTech Connect

    Cerchiai, Bianca L.; Zumino, Bruno; Ferrara, Sergio; Marrani, Alessio

    2009-06-15

    We consider the Bekenstein-Hawking entropy-area formula in four dimensional extended ungauged supergravity and its electric-magnetic duality property. Symmetries of both 'large' and 'small' extremal black holes are considered, as well as the ADM mass formula for N=4 and N=8 supergravity, preserving different fraction of supersymmetry. The interplay between BPS conditions and duality properties is an important aspect of this investigation.

  10. Duality, Entropy and ADM Mass in Supergravity

    SciTech Connect

    Cerchiai, Bianca L.; Ferrara, Sergio; Marrani, Alessio; Zumino, Bruno

    2009-02-23

    We consider the Bekenstein-Hawking entropy-area formula in four dimensional extended ungauged supergravity and its electric-magnetic duality property. Symmetries of both"large" and"small" extremal black holes are considered, as well as the ADM mass formula for N=4 and N=8 supergravity, preserving different fraction of supersymmetry. The interplay between BPS conditions and duality properties is an important aspect of this investigation.

  11. In Silico Approaches for Predicting Adme Properties

    NASA Astrophysics Data System (ADS)

    Madden, Judith C.

    A drug requires a suitable pharmacokinetic profile to be efficacious in vivo in humans. The relevant pharmacokinetic properties include the absorption, distribution, metabolism, and excretion (ADME) profile of the drug. This chapter provides an overview of the definition and meaning of key ADME properties, recent models developed to predict these properties, and a guide as to how to select the most appropriate model(s) for a given query. Many tools using the state-of-the-art in silico methodology are now available to users, and it is anticipated that the continual evolution of these tools will provide greater ability to predict ADME properties in the future. However, caution must be exercised in applying these tools as data are generally available only for "successful" drugs, i.e., those that reach the marketplace, and little supplementary information, such as that for drugs that have a poor pharmacokinetic profile, is available. The possibilities of using these methods and possible integration into toxicity prediction are explored.

  12. Building Leadership Capacity in Early Childhood Pre-Service Teachers

    ERIC Educational Resources Information Center

    Campbell-Evans, Glenda; Stamopoulos, Elizabeth; Maloney, Carmel

    2014-01-01

    Building leadership capacity has emerged as a key concern within the early childhood profession in Australia as the sector responds to recent national reforms focusing on raising standards and improving quality provision of services. The purpose of this paper is to contribute to the discussion around these reforms and to make a case for changes…

  13. 50. Interior of launch support building, service disconnect at bottom ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. Interior of launch support building, service disconnect at bottom center, repeater rack at right, view towards southwest - Ellsworth Air Force Base, Delta Flight, Launch Facility, On County Road T512, south of Exit 116 off I-90, Interior, Jackson County, SD

  14. 8. Interior view, industrial service building, showing breaker panels made ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Interior view, industrial service building, showing breaker panels made of natural stone; four switches on each panel had been connected to box on wall by wires routed through conduit buried in concrete floor; view to northwest. - Charlestown Navy Yard, Pier 11, Charlestown Waterfront at confluence of Little Mystic Channel & Mystic River at northernmost ent of Navy Yard, Boston, Suffolk County, MA

  15. 5. View of industrial service building at center of pier, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. View of industrial service building at center of pier, looking southeast with Boston in distance. - Charlestown Navy Yard, Pier 11, Charlestown Waterfront at confluence of Little Mystic Channel & Mystic River at northernmost ent of Navy Yard, Boston, Suffolk County, MA

  16. The ADM-AEOLUS Solar Array

    NASA Astrophysics Data System (ADS)

    Riva, S.; Ferrando, E.; Contini, R.; Blok, R.; Heijden, R. vd; Caon, A.; Labruyere, G.; Strobl, G.; Koestler, W.; Zimmermann, W.

    2008-09-01

    ADM Aeolus is an Earth Explorer Core Mission of the European Space Agency (ESA). The satellite is provided with a deployable solar array fully equipped with European state of the art Triple Junction (TJ) GaAs solar cells.The structural part and mechanisms of the ADM Aeolus Solar Array (SA) is a derivate of the Dutch Space FRED solar array concept. This FRED type solar array has already been used on Jules Verne (Automated Transfer Vehicle) and Giove-A. Both satellites has been successfully launched and the Solar Arrays are working nominally.The ADM Aeolus spacecraft (S/C) is powered by two deployable wings. Each of them composed by three panels and with a panel size of 1.1×2.2 m2, so that the total area is about 14.5 m2;. European TJ solar cells (27% efficiency class) embodying an integral protection diode were selected to meet the power budget, necessary for the installed payload. The principal one is an Atmospheric LAser Doppler INstrument (ALADIN), a novel system whose development is a strategic goal for ESA.This SA program is a challenging development in terms of solar cell qualification because of the extensive characterisation and qualification campaign performed for the cell and the integral diode components. Especially for protection diode a long duration high temperature test was performed in order to simulate and cover all lifetime stresses.Main drivers for PVA design are the power requirement at the end of life and the requested protection against atomic oxygen erosion.This paper describes : The results achieved during the qualification phase, from bare cell level to the coupon level, The design activity, mainly focused on the prediction of EOL performances, The acceptance phase at panel levels, which has verified the suitability of the design assumption and manufacturing workmanship.

  17. Commercial Building Loads Providing Ancillary Services in PJM

    SciTech Connect

    MacDonald, Jason; Kiliccote, Sila; Boch, Jim; Chen, Jonathan; Nawy, Robert

    2014-06-27

    The adoption of low carbon energy technologies such as variable renewable energy and electric vehicles, coupled with the efficacy of energy efficiency to reduce traditional base load has increased the uncertainty inherent in the net load shape. Handling this variability with slower, traditional resources leads to inefficient system dispatch, and in some cases may compromise reliability. Grid operators are looking to future energy technologies, such as automated demand response (DR), to provide capacity-based reliability services as the need for these services increase. While DR resources are expected to have the flexibility characteristics operators are looking for, demonstrations are necessary to build confidence in their capabilities. Additionally, building owners are uncertain of the monetary value and operational burden of providing these services. To address this, the present study demonstrates the ability of demand response resources providing two ancillary services in the PJM territory, synchronous reserve and regulation, using an OpenADR 2.0b signaling architecture. The loads under control include HVAC and lighting at a big box retail store and variable frequency fan loads. The study examines performance characteristics of the resource: the speed of response, communications latencies in the architecture, and accuracy of response. It also examines the frequency and duration of events and the value in the marketplace which can be used to examine if the opportunity is sufficient to entice building owners to participate.

  18. The Cancer Information Service: using CBPR in building community capacity.

    PubMed

    Davis, Sharon Watkins; Cassel, Kevin; Moseley, Michelle Axel; Mesia, Rachel; De Herrera, Paula Amezola; Kornfeld, Julie; Perocchia, Rosemarie

    2011-03-01

    The National Cancer Institute's (NCIs) Cancer Information Service (CIS) Partnership Program followed many of the key principles of community-based participatory research in providing technical assistance to partner organizations. Using five case studies, this article describes how the CIS Partnership Program served to identify community needs and leaders, bringing resources together to build capacity and increase knowledge, and facilitate further dissemination of findings. CIS Partnership Program staff transcended the traditional health education role by building the capacity of community partners to bring cancer information in culturally appropriate ways to their own communities. The lessons learned by the CIS Partnership Program are useful for both academics and service organizations that would benefit from working with medically underserved communities. PMID:20872106

  19. Old Buildings Broadband Home Networks: Technologies and Services Overview

    NASA Astrophysics Data System (ADS)

    Fantacci, Romano; Pecorella, Tommaso; Micciullo, Luigia; Viti, Roberto; Pasquini, Vincenzo; Calì, Marco

    2014-05-01

    Internet broadband access is becoming a reality in many countries. To fully exploit the benefits from high-speed connection, both suitable home network connectivity and advanced services support have to be made available to the user. In this article, issues relative to the upgrade of existing home networks, particularly in old buildings, together with networking and security requirements are addressed, and possible solutions are proposed.

  20. Building asynchronous geospatial processing workflows with web services

    NASA Astrophysics Data System (ADS)

    Zhao, Peisheng; Di, Liping; Yu, Genong

    2012-02-01

    Geoscience research and applications often involve a geospatial processing workflow. This workflow includes a sequence of operations that use a variety of tools to collect, translate, and analyze distributed heterogeneous geospatial data. Asynchronous mechanisms, by which clients initiate a request and then resume their processing without waiting for a response, are very useful for complicated workflows that take a long time to run. Geospatial contents and capabilities are increasingly becoming available online as interoperable Web services. This online availability significantly enhances the ability to use Web service chains to build distributed geospatial processing workflows. This paper focuses on how to orchestrate Web services for implementing asynchronous geospatial processing workflows. The theoretical bases for asynchronous Web services and workflows, including asynchrony patterns and message transmission, are examined to explore different asynchronous approaches to and architecture of workflow code for the support of asynchronous behavior. A sample geospatial processing workflow, issued by the Open Geospatial Consortium (OGC) Web Service, Phase 6 (OWS-6), is provided to illustrate the implementation of asynchronous geospatial processing workflows and the challenges in using Web Services Business Process Execution Language (WS-BPEL) to develop them.

  1. Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

    PubMed Central

    Tibbitts, Jay; Canter, David; Graff, Ryan; Smith, Alison; Khawli, Leslie A.

    2016-01-01

    abstract Protein therapeutics represent a diverse array of biologics including antibodies, fusion proteins, and therapeutic replacement enzymes. Since their inception, they have revolutionized the treatment of a wide range of diseases including respiratory, vascular, autoimmune, inflammatory, infectious, and neurodegenerative diseases, as well as cancer. While in vivo pharmacokinetic, pharmacodynamic, and efficacy studies are routinely carried out for protein therapeutics, studies that identify key factors governing their absorption, distribution, metabolism, and excretion (ADME) properties have not been fully investigated. Thorough characterization and in-depth study of their ADME properties are critical in order to support drug discovery and development processes for the production of safer and more effective biotherapeutics. In this review, we discuss the main factors affecting the ADME characteristics of these large macromolecular therapies. We also give an overview of the current tools, technologies, and approaches available to investigate key factors that influence the ADME of recombinant biotherapeutic drugs, and demonstrate how ADME studies will facilitate their future development. PMID:26636901

  2. PUS Services Software Building Block Automatic Generation for Space Missions

    NASA Astrophysics Data System (ADS)

    Candia, S.; Sgaramella, F.; Mele, G.

    2008-08-01

    The Packet Utilization Standard (PUS) has been specified by the European Committee for Space Standardization (ECSS) and issued as ECSS-E-70-41A to define the application-level interface between Ground Segments and Space Segments. The ECSS-E- 70-41A complements the ECSS-E-50 and the Consultative Committee for Space Data Systems (CCSDS) recommendations for packet telemetry and telecommand. The ECSS-E-70-41A characterizes the identified PUS Services from a functional point of view and the ECSS-E-70-31 standard specifies the rules for their mission-specific tailoring. The current on-board software design for a space mission implies the production of several PUS terminals, each providing a specific tailoring of the PUS services. The associated on-board software building blocks are developed independently, leading to very different design choices and implementations even when the mission tailoring requires very similar services (from the Ground operative perspective). In this scenario, the automatic production of the PUS services building blocks for a mission would be a way to optimize the overall mission economy and improve the robusteness and reliability of the on-board software and of the Ground-Space interactions. This paper presents the Space Software Italia (SSI) activities for the development of an integrated environment to support: the PUS services tailoring activity for a specific mission. the mission-specific PUS services configuration. the generation the UML model of the software building block implementing the mission-specific PUS services and the related source code, support documentation (software requirements, software architecture, test plans/procedures, operational manuals), and the TM/TC database. The paper deals with: (a) the project objectives, (b) the tailoring, configuration, and generation process, (c) the description of the environments supporting the process phases, (d) the characterization of the meta-model used for the generation, (e) the

  3. 41 CFR 102-74.35 - What building services must Executive agencies provide?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What building services...-FACILITY MANAGEMENT Facility Management Occupancy Services § 102-74.35 What building services must Executive agencies provide? Executive agencies, upon approval from GSA, must provide— (a) Building...

  4. 41 CFR 102-74.35 - What building services must Executive agencies provide?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What building services...-FACILITY MANAGEMENT Facility Management Occupancy Services § 102-74.35 What building services must Executive agencies provide? Executive agencies, upon approval from GSA, must provide— (a) Building...

  5. 41 CFR 102-74.35 - What building services must Executive agencies provide?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What building services...-FACILITY MANAGEMENT Facility Management Occupancy Services § 102-74.35 What building services must Executive agencies provide? Executive agencies, upon approval from GSA, must provide— (a) Building...

  6. 48 CFR 552.232-72 - Final Payment Under Building Services Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Building Services Contracts. 552.232-72 Section 552.232-72 Federal Acquisition Regulations System GENERAL... and Clauses 552.232-72 Final Payment Under Building Services Contracts. As prescribed in 532.904(c), insert the following clause: Final Payment Under Building Services Contracts (MAR 2012) Before...

  7. 48 CFR 552.232-72 - Final Payment Under Building Services Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Building Services Contracts. 552.232-72 Section 552.232-72 Federal Acquisition Regulations System GENERAL... and Clauses 552.232-72 Final Payment Under Building Services Contracts. As prescribed in 532.904(c), insert the following clause: Final Payment Under Building Services Contracts (MAR 2012) Before...

  8. 48 CFR 552.232-72 - Final Payment Under Building Services Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Building Services Contracts. 552.232-72 Section 552.232-72 Federal Acquisition Regulations System GENERAL... and Clauses 552.232-72 Final Payment Under Building Services Contracts. As prescribed in 532.904(c), insert the following clause: Final Payment Under Building Services Contracts (MAR 2012) Before...

  9. 48 CFR 652.236-71 - Foreign Service Buildings Act, as Amended.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Foreign Service Buildings....236-71 Foreign Service Buildings Act, as Amended. As prescribed in 636.570(a), insert the following provision: Foreign Service Buildings Act, as Amended (APR 2004) (a) This solicitation is subject to...

  10. 48 CFR 652.236-71 - Foreign Service Buildings Act, as Amended.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Foreign Service Buildings....236-71 Foreign Service Buildings Act, as Amended. As prescribed in 636.570(a), insert the following provision: Foreign Service Buildings Act, as Amended (APR 2004) (a) This solicitation is subject to...

  11. 48 CFR 652.236-71 - Foreign Service Buildings Act, as Amended.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Foreign Service Buildings....236-71 Foreign Service Buildings Act, as Amended. As prescribed in 636.570(a), insert the following provision: Foreign Service Buildings Act, as Amended (APR 2004) (a) This solicitation is subject to...

  12. 41 CFR 102-74.35 - What building services must Executive agencies provide?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What building services...-FACILITY MANAGEMENT Facility Management Occupancy Services § 102-74.35 What building services must Executive agencies provide? Executive agencies, upon approval from GSA, must provide— (a) Building...

  13. ADME-Tox profiles of some food additives and pesticides

    NASA Astrophysics Data System (ADS)

    Craciun, Dana; Modra, Dorina; Isvoran, Adriana

    2015-12-01

    Within this study we compute the Absorption, Distribution, Metabolism, Excretion and Toxicity (ADME-Tox) profiles of several commonly used food additives and some pesticides. As expected, all the food additives considered in this study provided to be safe, their ADME-Tox profiles indicating that they have a good oral bioavailability and they do not produce phosphoslipidosis. The ADME-Tox profiles of the pesticides indicate that, with a few exceptions, they are highly toxic (some of them being not approved in the EU, but still used in other countries) and may cause many diseases. Our results are in good agreement with published data concerning the considered food additives and pesticides revealing that the ADME-Tox profiling method may be successfully used to test other chemicals than drug candidates.

  14. 20 CFR 672.505 - How may grantees provide services under the YouthBuild program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... YouthBuild program? 672.505 Section 672.505 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... Limitations § 672.505 How may grantees provide services under the YouthBuild program? Each recipient of a grant under the YouthBuild program may provide the services and activities described in...

  15. 20 CFR 672.505 - How may grantees provide services under the YouthBuild program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... YouthBuild program? 672.505 Section 672.505 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... Limitations § 672.505 How may grantees provide services under the YouthBuild program? Each recipient of a grant under the YouthBuild program may provide the services and activities described in...

  16. 20 CFR 672.505 - How may grantees provide services under the YouthBuild program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... YouthBuild program? 672.505 Section 672.505 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... Limitations § 672.505 How may grantees provide services under the YouthBuild program? Each recipient of a grant under the YouthBuild program may provide the services and activities described in...

  17. AstroTaverna-Building workflows with Virtual Observatory services

    NASA Astrophysics Data System (ADS)

    Ruiz, J. E.; Garrido, J.; Santander-Vela, J. D.; Sánchez-Expósito, S.; Verdes-Montenegro, L.

    2014-11-01

    Despite the long tradition of publishing digital datasets in Astronomy, and the existence of a rich network of services providing astronomical datasets in standardized interoperable formats through the Virtual Observatory (VO), there has been little use of scientific workflow technologies in this field. In this paper we present AstroTaverna, a plugin that we have developed for the Taverna Workbench scientific workflow management system. It integrates existing VO web services as first-class building blocks in Taverna workflows, allowing the digital capture of otherwise lost procedural steps manually performed in e.g. GUI tools, providing reproducibility and re-use. It improves the readability of digital VO recipes with a comprehensive view of the entire automated execution process, complementing the scarce narratives produced in the classic documentation practices, transforming them into living tutorials for an efficient use of the VO infrastructure. The plugin also adds astronomical data manipulation and transformation tools based on the STIL Tool Set and the integration of Aladin VO software, as well as interactive connectivity with SAMP-compliant astronomy tools.

  18. REACTOR SERVICE BUILDING, TRA635, CONTEXTUAL VIEW DURING CONSTRUCTION. CAMERA IS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICE BUILDING, TRA-635, CONTEXTUAL VIEW DURING CONSTRUCTION. CAMERA IS ATOP MTR BUILDING AND LOOKING SOUTHERLY. FOUNDATION AND DRAINS ARE UNDER CONSTRUCTION. THE BUILDING WILL BUTT AGAINST CHARGING FACE OF PLUG STORAGE BUILDING. HOT CELL BUILDING, TRA-632, IS UNDER CONSTRUCTION AT TOP CENTER OF VIEW. INL NEGATIVE NO. 8518. Unknown Photographer, 8/25/1953 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  19. 75 FR 20598 - Public Buildings Service; Prospect Island, Sacramento Delta, Solano County, CA; Transfer of Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-20

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Public Buildings Service; Prospect Island, Sacramento Delta, Solano County, CA; Transfer of... identified as Prospect Island, Sacramento Delta, Solano County, California to the State of...

  20. LOFT. Containment and service building (TAN650) basement floor plan. Basement ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOFT. Containment and service building (TAN-650) basement floor plan. Basement airlock, shielded roadway, service areas, connection to control building. Kaiser engineers 6413-11-STEP/LOFT-650-A-1. Date: October 1964. INEEL index code no. 036-650-00-416-122213 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  1. 48 CFR 652.236-71 - Foreign Service Buildings Act, as Amended.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....236-71 Foreign Service Buildings Act, as Amended. As prescribed in 636.570(a), insert the following provision: Foreign Service Buildings Act, as Amended (APR 2004) (a) This solicitation is subject to Section...) Performance of similar construction work in the United States; and (2) Either— (i) Ownership in excess of...

  2. Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

    PubMed Central

    2015-01-01

    On the order of hundreds of absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) models have been described in the literature in the past decade which are more often than not inaccessible to anyone but their authors. Public accessibility is also an issue with computational models for bioactivity, and the ability to share such models still remains a major challenge limiting drug discovery. We describe the creation of a reference implementation of a Bayesian model-building software module, which we have released as an open source component that is now included in the Chemistry Development Kit (CDK) project, as well as implemented in the CDD Vault and in several mobile apps. We use this implementation to build an array of Bayesian models for ADME/Tox, in vitro and in vivo bioactivity, and other physicochemical properties. We show that these models possess cross-validation receiver operator curve values comparable to those generated previously in prior publications using alternative tools. We have now described how the implementation of Bayesian models with FCFP6 descriptors generated in the CDD Vault enables the rapid production of robust machine learning models from public data or the user’s own datasets. The current study sets the stage for generating models in proprietary software (such as CDD) and exporting these models in a format that could be run in open source software using CDK components. This work also demonstrates that we can enable biocomputation across distributed private or public datasets to enhance drug discovery. PMID:25994950

  3. Recent progresses in the exploration of machine learning methods as in-silico ADME prediction tools.

    PubMed

    Tao, L; Zhang, P; Qin, C; Chen, S Y; Zhang, C; Chen, Z; Zhu, F; Yang, S Y; Wei, Y Q; Chen, Y Z

    2015-06-23

    In-silico methods have been explored as potential tools for assessing ADME and ADME regulatory properties particularly in early drug discovery stages. Machine learning methods, with their ability in classifying diverse structures and complex mechanisms, are well suited for predicting ADME and ADME regulatory properties. Recent efforts have been directed at the broadening of application scopes and the improvement of predictive performance with particular focuses on the coverage of ADME properties, and exploration of more diversified training data, appropriate molecular features, and consensus modeling. Moreover, several online machine learning ADME prediction servers have emerged. Here we review these progresses and discuss the performances, application prospects and challenges of exploring machine learning methods as useful tools in predicting ADME and ADME regulatory properties. PMID:26037068

  4. Building Geospatial Web Services for Ecological Monitoring and Forecasting

    NASA Astrophysics Data System (ADS)

    Hiatt, S. H.; Hashimoto, H.; Melton, F. S.; Michaelis, A. R.; Milesi, C.; Nemani, R. R.; Wang, W.

    2008-12-01

    The Terrestrial Observation and Prediction System (TOPS) at NASA Ames Research Center is a modeling system that generates a suite of gridded data products in near real-time that are designed to enhance management decisions related to floods, droughts, forest fires, human health, as well as crop, range, and forest production. While these data products introduce great possibilities for assisting management decisions and informing further research, realization of their full potential is complicated by their shear volume and by the need for a necessary infrastructure for remotely browsing, visualizing, and analyzing the data. In order to address these difficulties we have built an OGC-compliant WMS and WCS server based on an open source software stack that provides standardized access to our archive of data. This server is built using the open source Java library GeoTools which achieves efficient I/O and image rendering through Java Advanced Imaging. We developed spatio-temporal raster management capabilities using the PostGrid raster indexation engine. We provide visualization and browsing capabilities through a customized Ajax web interface derived from the kaMap project. This interface allows resource managers to quickly assess ecosystem conditions and identify significant trends and anomalies from within their web browser without the need to download source data or install special software. Our standardized web services also expose TOPS data to a range of potential clients, from web mapping applications to virtual globes and desktop GIS packages. However, support for managing the temporal dimension of our data is currently limited in existing software systems. Future work will attempt to overcome this shortcoming by building time-series visualization and analysis tools that can be integrated with existing geospatial software.

  5. In silico ADME/T modelling for rational drug design.

    PubMed

    Wang, Yulan; Xing, Jing; Xu, Yuan; Zhou, Nannan; Peng, Jianlong; Xiong, Zhaoping; Liu, Xian; Luo, Xiaomin; Luo, Cheng; Chen, Kaixian; Zheng, Mingyue; Jiang, Hualiang

    2015-11-01

    In recent decades, in silico absorption, distribution, metabolism, excretion (ADME), and toxicity (T) modelling as a tool for rational drug design has received considerable attention from pharmaceutical scientists, and various ADME/T-related prediction models have been reported. The high-throughput and low-cost nature of these models permits a more streamlined drug development process in which the identification of hits or their structural optimization can be guided based on a parallel investigation of bioavailability and safety, along with activity. However, the effectiveness of these tools is highly dependent on their capacity to cope with needs at different stages, e.g. their use in candidate selection has been limited due to their lack of the required predictability. For some events or endpoints involving more complex mechanisms, the current in silico approaches still need further improvement. In this review, we will briefly introduce the development of in silico models for some physicochemical parameters, ADME properties and toxicity evaluation, with an emphasis on the modelling approaches thereof, their application in drug discovery, and the potential merits or deficiencies of these models. Finally, the outlook for future ADME/T modelling based on big data analysis and systems sciences will be discussed. PMID:26328949

  6. ADM. Tanks: from left to right: fuel oil tank, fuel ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ADM. Tanks: from left to right: fuel oil tank, fuel pump house (TAN-611), engine fuel tank, water pump house, water storage tank. Camera facing northwest. Not edge of shielding berm at left of view. Date: November 25, 1953. INEEL negative no. 9217 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  7. Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

    PubMed Central

    Yang, Zhen; Kulkarni, Kaustubh; Zhu, Wei; Hu, Ming

    2014-01-01

    Genistein, one of the most active natural flavonoids, exerts various biological effects including chemoprevention, antioxidation, antiproliferation and anticancer. More than 30 clinical trials of genistein with various disease indications have been conducted to evaluate its clinical efficacy. Based on many animals and human pharmacokinetic studies, it is well known that the most challenge issue for developing genistein as a chemoprevention agent is the low oral bioavailability, which may be the major reason relating to its ambiguous therapeutic effects and large interindividual variations in clinical trials. In order to better correlate pharmacokinetic to pharmacodynamics results in animals and clinical studies, an in-depth understanding of pharmacokinetic behavior of genistein and its ADME properties are needed. Numerous in vitro/in vivo ADME studies had been conducted to reveal the main factors contributing to the low oral bioavailability of genistein. Therefore, this review focuses on summarizing the most recent progress on mechanistic studies of genistein ADME and provides a systemic view of these processes to explain genistein pharmacokinetic behaviors in vivo. The better understanding of genistein ADME property may lead to development of proper strategy to improve genistein oral bioavailability via mechanism-based approaches. PMID:22583407

  8. Progress in predicting human ADME parameters in silico.

    PubMed

    Ekins, S; Waller, C L; Swaan, P W; Cruciani, G; Wrighton, S A; Wikel, J H

    2000-01-01

    Understanding the development of a scientific approach is a valuable exercise in gauging the potential directions the process could take in the future. The relatively short history of applying computational methods to absorption, distribution, metabolism and excretion (ADME) can be split into defined periods. The first began in the 1960s and continued through the 1970s with the work of Corwin Hansch et al. Their models utilized small sets of in vivo ADME data. The second era from the 1980s through 1990s witnessed the widespread incorporation of in vitro approaches as surrogates of in vivo ADME studies. These approaches fostered the initiation and increase in interpretable computational ADME models available in the literature. The third era is the present were there are many literature data sets derived from in vitro data for absorption, drug-drug interactions (DDI), drug transporters and efflux pumps [P-glycoprotein (P-gp), MRP], intrinsic clearance and brain penetration, which can theoretically be used to predict the situation in vivo in humans. Combinatorial synthesis, high throughput screening and computational approaches have emerged as a result of continual pressure on pharmaceutical companies to accelerate drug discovery while decreasing drug development costs. The goal has become to reduce the drop-out rate of drug candidates in the latter, most expensive stages of drug development. This is accomplished by increasing the failure rate of candidate compounds in the preclinical stages and increasing the speed of nomination of likely clinical candidates. The industry now understands the reasons for clinical failure other than efficacy are mainly related to pharmacokinetics and toxicity. The late 1990s saw significant company investment in ADME and drug safety departments to assess properties such as metabolic stability, cytochrome P-450 inhibition, absorption and genotoxicity earlier in the drug discovery paradigm. The next logical step in this process is the

  9. Strategic service-line planning. Building competitive advantage.

    PubMed

    Greenspan, Elizabeth; Krentz, Susanna E; O'Neill, Molly K

    2003-12-01

    Service-line planning requires a healthcare organization to develop a business plan for each of its service lines. Successful service-line planning requires top leadership support, a willingness to allocate resources, the development of support mechanisms, the active support and involvement of physicians, and management commitment and accountability during implementation. PMID:14686076

  10. Atmospheric dispersion of an elevated release in a rural environment: Comparison between field SF 6 tracer measurements and computations of Briggs and ADMS models

    NASA Astrophysics Data System (ADS)

    Connan, O.; Leroy, C.; Derkx, F.; Maro, D.; Hébert, D.; Roupsard, P.; Rozet, M.

    2011-12-01

    The French Institute for Radiological Protection and Nuclear Safety (IRSN), in collaboration with VEOLIA (French environmental services company), conducted experimental campaigns to study atmospheric dispersion around an Energy Recycling Unit (EUR). The objectives were to study dispersion for an elevated release in a rural environment and to compare results with those of models. The atmospheric dispersion was studied by SF 6 tracer injection into a 40 m high stack. Maximum values of experimental Atmospheric Transfer Coefficients (ATC max) and horizontal dispersion standard deviations ( σh) were compared to predictions from a first generation Briggs gaussian model as well as results from the latest generation ADMS 4.1 gaussian model. In neutral atmospheric conditions, the Briggs and ADMS models are in good agreement with experimental data in terms of ATC and σh. In unstable condition, for σh, both ADMS and Briggs models slightly overestimate the data for winter and summer conditions. In unstable conditions, ADMS and Briggs models overestimated ATC max. The statistical evaluation of the models versus experimental data shows neither models ever meets all of the criteria for good performance. However, statistical evaluation indicates that the ADMS model is more suitable for neutral condition, and that the Briggs model is more reliable for summer unstable conditions.

  11. REACTOR SERVICES BUILDING, TRA635. SOUTH SIDE. CAMERA FACING NORTH. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICES BUILDING, TRA-635. SOUTH SIDE. CAMERA FACING NORTH. INL NEGATIVE NO. HD46-41-1. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  12. Building Community Capacity through School-Based Service-Learning

    ERIC Educational Resources Information Center

    Jacobus, Michelle Vazquez; Baskett, Robert

    2010-01-01

    This article describes the opportunities and challenges encountered in the service-learning adaptation of an early childhood primary prevention program through the University of Southern Maine's Lewiston Auburn College. In the face of economic and social challenges confronted by many communities, service-learning models are proposed as essential…

  13. Building for Hope: Progressive Service Learning Enhances Education.

    ERIC Educational Resources Information Center

    Burr, Kevin L.

    2001-01-01

    Technology teacher education students formulated and executed a service learning project in which they organized a mock production company and produced and marketed a product. Proceeds were donated to charity. The project integrated learning about manufacturing operations with community service. (SK)

  14. LOFT. Containment and service building (TAN650). Section through east/west axis ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOFT. Containment and service building (TAN-650). Section through east/west axis of building as viewed from the south. Shows basement and grade levels of containment building, connection to control room on west side, air filter vaults, and duct enclosure for air exhaust system. Kaiser engineers 6413-11-STEP/LOFT-650-A-4. Date: October 1964. INEEL index code no. 036-650-00-486-122216 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  15. 48 CFR 532.905-70 - Final payment-construction and building service contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 552.232-72. (b) Contracting officers may not process the final payment on construction or building... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply...

  16. 48 CFR 532.905-70 - Final payment-construction and building service contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 552.232-72. (b) Contracting officers may not process the final payment on construction or building... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply...

  17. 48 CFR 532.905-70 - Final payment-construction and building service contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 552.232-72. (b) Contracting officers may not process the final payment on construction or building... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply...

  18. REACTOR SERVICE BUILDING, TRA635. CROWDED MOCKUP AREA. CAMERA FACES EAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICE BUILDING, TRA-635. CROWDED MOCK-UP AREA. CAMERA FACES EAST. PHOTOGRAPHER'S NOTE SAYS "PICTURE REQUESTED BY IDO IN SUPPORT OF FY '58 BUILDING PROJECTS." INL NEGATIVE NO. 56-3025. R.G. Larsen, Photographer, 9/13/1956 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  19. REACTOR SERVICES BUILDING, TRA635. EAST SIDE. CAMERA LOOKING NORTHWEST. MTR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICES BUILDING, TRA-635. EAST SIDE. CAMERA LOOKING NORTHWEST. MTR BUILDING, TRA-603, AT RIGHT OF VIEW. INL NEGATIVE NO. HD46-41-2. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  20. REACTOR SERVICES BUILDING, TRA635, INTERIOR. ALSO KNOWN AS MATERIAL RECEIVING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICES BUILDING, TRA-635, INTERIOR. ALSO KNOWN AS MATERIAL RECEIVING AREA AND LABORATORY. CAMERA ON FIRST FLOOR FACING NORTH TOWARD MTR BUILDING. MOCK-UP AREA WAS TO THE RIGHT OF VIEW. INL NEGATIVE NO. HD46-10-1. Mike Crane, Photographer, 2/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  1. 41 CFR 102-74.35 - What building services must Executive agencies provide?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... display P.O.W. and M.I.A. flags at locations specified in 36 U.S.C. 902 on P.O.W./M.I.A. flag display days... Executive agencies provide? Executive agencies, upon approval from GSA, must provide— (a) Building services... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What building...

  2. 41 CFR 105-53.147 - Public Buildings Service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... (c) Regulations. Regulations pertaining to PBS programs are published in 41 CFR chapter 1, 41 CFR chapter 101, subchapters D and H; and in 48 CFR chapter 1. Information on availability of the regulations... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Public Buildings...

  3. 41 CFR 105-53.147 - Public Buildings Service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... (c) Regulations. Regulations pertaining to PBS programs are published in 41 CFR chapter 1, 41 CFR chapter 101, subchapters D and H; and in 48 CFR chapter 1. Information on availability of the regulations... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Public Buildings...

  4. 41 CFR 105-53.147 - Public Buildings Service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... (c) Regulations. Regulations pertaining to PBS programs are published in 41 CFR chapter 1, 41 CFR chapter 101, subchapters D and H; and in 48 CFR chapter 1. Information on availability of the regulations... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Public Buildings...

  5. 41 CFR 105-53.147 - Public Buildings Service.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (c) Regulations. Regulations pertaining to PBS programs are published in 41 CFR chapter 1, 41 CFR chapter 101, subchapters D and H; and in 48 CFR chapter 1. Information on availability of the regulations... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Public Buildings...

  6. 41 CFR 105-53.147 - Public Buildings Service.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (c) Regulations. Regulations pertaining to PBS programs are published in 41 CFR chapter 1, 41 CFR chapter 101, subchapters D and H; and in 48 CFR chapter 1. Information on availability of the regulations... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Public Buildings...

  7. Conservative mastectomies and immediate reconstruction with the use of ADMs

    PubMed Central

    Govshievich, Alexander; Somogyi, Ron B.

    2015-01-01

    Background In recent years, a novel approach to immediate breast reconstruction has been introduced with the advent of acellular dermal matrix (ADM). In the setting of conservative mastectomies where the native skin envelope is preserved, placement of ADM at the lower pole in continuity with the pectoralis major muscle (PMM) provides additional support, allowing direct-to-implant breast reconstruction. The following manuscript presents the senior author’s experience with ADM-assisted reconstruction and provides a detailed description of surgical technique along with a comprehensive discussion of patient selection and potential complications. Methods A retrospective chart review of patients undergoing direct-to-implant breast reconstruction following skin sparing or nipple sparing mastectomy with the use of ADM (AlloDerm; LifeCell Corp., Branchburg, USA) was conducted at Women’s College Hospital in Toronto over a 5-year period [2008-2013]. Demographic data, previous radiation therapy and post-operative complications were recorded. Results A total of 72 patients representing 119 breasts were identified. Average follow-up was 16 months (range, 3-51 months). Twenty-seven complications were recorded for a complication rate of 22.7% (27/119). Complications included six cases of capsular contracture (Baker III/IV), five cases of red skin syndrome, four cases of rippling, three cases of dehiscence and two cases of seroma. Overall, direct-to-implant reconstruction was successfully completed in 97.5% of breasts (116/119). One case of infection was treated with explantation and conversion to autogenous reconstruction. Two breasts with tissue necrosis or dehiscence had the implants removed and replaced with tissue expanders. Overall reoperation rate was 9.7% (7/72 patients). Conclusions ADM assisted direct-to-implant breast reconstruction has been shown to be a safe option for women who are candidates for skin sparing or nipple sparing mastectomies. Judicious patient

  8. A Community Development Approach to Service-Learning: Building Social Capital between Rural Youth and Adults

    ERIC Educational Resources Information Center

    Henness, Steven A.; Ball, Anna L.; Moncheski, MaryJo

    2013-01-01

    Using 4-H and FFA case study findings, this article explores how community service-learning supports the building of social capital between rural youth and adults and the positive effects on community viability. Key elements of practice form a community development approach to service-learning, which opens up doorways for youth to partner with…

  9. 24 CFR 901.40 - Indicator #7, resident services and community building.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... services and community building. This indicator examines the PHA's efforts to deliver quality customer..., including non-PHA service providers, that help improve management operations at the PHA; and to encourage... indicator examines PHA performance under any special HUD grant(s) administered by the PHA. PHAs can...

  10. Building to Scale: An Analysis of Web-Based Services in CIC (Big Ten) Libraries.

    ERIC Educational Resources Information Center

    Dewey, Barbara I.

    Advancing library services in large universities requires creative approaches for "building to scale." This is the case for CIC, Committee on Institutional Cooperation (Big Ten), libraries whose home institutions serve thousands of students, faculty, staff, and others. Developing virtual Web-based services is an increasingly viable avenue to bring…

  11. Building Culturally & Linguistically Competent Services to Support Young Children, Their Families, and School Readiness

    ERIC Educational Resources Information Center

    Hepburn, Kathy Seitzinger

    2004-01-01

    The purpose of this tool kit is to provide guidance, tools, and resources that will assist communities in building culturally and linguistically competent services, supports, programs, and practices related to young children, their families. By offering services in culturally and linguistically meaningful ways, communities can engage all families…

  12. The AskA Starter Kit: How To Build and Maintain Digital Reference Services.

    ERIC Educational Resources Information Center

    Lankes, R. David; Kasowitz, Abby S.

    This Starter Kit is designed to help organizations and individuals who wish to offer human-mediated information services via the Internet to users in the K-12 community. A six-step process is proposed for organizations to follow in creating an "AskA" service. This process addresses all aspects involved in building and maintaining an AskA service…

  13. Social Services and Schools: Building Collaboration That Works.

    ERIC Educational Resources Information Center

    Liontos, Lynn Balster

    1991-01-01

    Public schools and social service agencies often serve the same clients and have some of the same goals. To achieve many of the goals that each sector is placing on its own reform agenda, complementary action is a must. For this publication, 13 interviews were conducted with both educators and social workers who have gained experience with the…

  14. Service Learning and Building Community with the World Wide Web

    ERIC Educational Resources Information Center

    Longan, Michael W.

    2007-01-01

    The geography education literature touts the World Wide Web (Web) as a revolutionary educational tool, yet most accounts ignore its uses for public communication and creative expression. This article argues that students can be producers of content that is of service to local audiences. Drawing inspiration from the community networking movement,…

  15. Human Resource Building--An Approach to Service Learning

    ERIC Educational Resources Information Center

    Rajan, Sonika

    2009-01-01

    Background: Isabella Thoburn College at Lucknow, Uttar Pradesh, India has initiated Service Learning Program for its students through 4 issue based centers. One of the centers AIDS Awareness Center for Counseling, Education, and Training (AACCET) is in the field of HIV/AIDS. It follows 6 pronged approach to achieve its objectives and one of the…

  16. 77 FR 59925 - Public Buildings Service; Submission for OMB Review; Application/Permit for Use of Space in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... ADMINISTRATION Public Buildings Service; Submission for OMB Review; Application/ Permit for Use of Space in Public Buildings and Grounds, GSA Form 3453 AGENCY: Public Buildings Service, GSA. ACTION: Notice of... Grounds. A notice was published in the Federal Register at 77 FR 38064, on June 26, 2012. No comments...

  17. Maintenance of Mechanical Services. Maintenance and Renewal in Educational Buildings. Building Bulletin 70.

    ERIC Educational Resources Information Center

    Haworth-Roberts, A., Ed.

    School building maintenance must find an appropriate balance between planned and reactive work in order to conserve costs. This document provides ways in which authorities can assess their maintenance requirements and make better use of the resources available. It considers how to deal with problems which have their roots in historical design…

  18. The definition of an atmospheric database for ADM-Aeolus

    NASA Astrophysics Data System (ADS)

    Marseille, G. J.; Houchi, K.; de Kloe, J.; Stoffelen, A.

    2010-05-01

    The definition of an atmospheric database is an important component of simulation studies in preparation of future earth observing remote sensing satellites. The ADM-Aeolus mission, scheduled for launch in medium 2012, aims at measuring wind profiles from the surface up to about 32 km with a global coverage. The vertical profile resolution is limited but may be changed during in-orbit operation. This provides the opportunity of a targeted sampling strategy, e.g., as a function of geographic region. Optimization of the vertical (and horizontal) sampling strategy requires a characterization of the atmosphere optical and dynamical properties, more in particular the distribution of atmospheric particles and their correlation with the atmospheric dynamics. The ADM-Aeolus atmospheric database combines meteorological data from the ECMWF model with atmosphere optical properties data from CALIPSO. An inverse algorithm to retrieve high-resolution particle backscatter from the CALIPSO level-1 attenuated backscatter product is presented. Global weather models tend to underestimate atmospheric wind variability. A procedure is described to ensure compatibility of the characteristics of the database winds with those from high-resolution radiosondes. The result is a high-resolution database of zonal, meridional and vertical wind, temperature, specific humidity and particle and molecular backscatter and extinction at 355 nm laser wavelength. This allows the simulation of small-scale atmospheric processes within the Aeolus observation sampling volume and their impact on the quality of the retrieved wind profiles. The database extends over four months covering all seasons. This allows a statistical evaluation of the mission components under investigaton. The database is currently used for the development of the ADM-Aeolus wind processing, the definition of wind calibration strategies and the optimization of the Aeolus sampling strategy.

  19. 77 FR 38064 - Public Buildings Service; Information Collection; GSA Form 3453, Application/Permit for Use of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... Space in Public Buildings and Grounds AGENCY: Public Buildings Service, GSA. ACTION: Notice of request... requirement regarding GSA Form 3453, Application/Permit for Use of Space in Public Buildings and Grounds... Information Collection 3090- 0044, GSA Form 3453, Application/Permit for Use of Space in Public Buildings...

  20. An overview of game-based learning in building services engineering education

    NASA Astrophysics Data System (ADS)

    Alanne, Kari

    2016-03-01

    To ensure proper competence development and short graduation times for engineering students, it is essential that the study motivation is encouraged by new learning methods. In game-based learning, the learner's engagement is increased and learning is made meaningful by applying game-like features such as competition and rewarding through virtual promotions or achievement badges. In this paper, the state of the art of game-based learning in building services engineering education at university level is reviewed and discussed. A systematic literature review indicates that educational games have been reported in the field of related disciplines, such as mechanical and civil engineering. The development of system-level educational games that realistically simulate work life in building services engineering is still in its infancy. Novel rewarding practices and more comprehensive approaches entailing the state-of-the-art information tools such as building information modelling, geographic information systems, building management systems and augmented reality are needed in the future.

  1. Expansion of the residential conservation service program to multi-family and small commercial buildings

    SciTech Connect

    1980-11-01

    Alternative regulatory provisions are considered which might permit achievement of the building energy conservation regulatory goals at a lower cost. Major issues, regulatory and legislative options, and cost-benefit analyses are discussed for multi-family and commercial buildings. The following are presented: related government programs, urban and community impact analysis, institutional impacts, energy cost, Residential Conservation Service coverage, methods of analysis, and regional studies. (MHR)

  2. REACTOR SERVICE BUILDING, TRA635, INTERIOR. CAMERA FACES NORTHWEST TOWARDS INTERIOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICE BUILDING, TRA-635, INTERIOR. CAMERA FACES NORTHWEST TOWARDS INTERIOR WALL ENCLOSING STORAGE AND OFFICE SPACE ALONG THE WEST SIDE. AT RIGHT EDGE IS DOOR TO MTR BUILDING. FROM RIGHT TO LEFT, SPACE WAS PLANNED FOR A LOCKER ROOM, MTR ISSUE ROOM, AND STORAGE AREAS AND RELATED OFFICES. NOTE SECOND "MEZZANINE" FLOOR ABOVE. INL NEGATIVE NO. 10227. Unknown Photographer, 3/23/1954 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  3. LOFT. Containment and service building (TAN650). Section through east/west axis ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOFT. Containment and service building (TAN-650). Section through east/west axis of building as viewed from the north. Shows steel ladder to top of dome, gable roof of borated water tank enclosure, pumice block siding of pre-amp tower, metal siding of duct enclosure. Kaiser engineers 6413-11-STEP/LOFT-650-A-6. Date: October 1964. INEEL index code no. 036-650-00-486-122218 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  4. Analysis of energy use in building services of the industrial sector in California: Two case studies

    SciTech Connect

    Akbari, H.; Sezgen, O.

    1991-09-01

    Energy-use patterns in many of California's fastest-growing industries are not typical of the existing mix of industries in the US. Many California firms operate small- and medium-sized facilities housed in buildings used simultaneously or interchangeably over time for commercial (office, retail, warehouse) and industrial activities. In these industrial subsectors, the energy required for building services (providing occupant comfort and necessities like lighting, HVAC, office equipment, computers, etc.) may be at least as important as the more familiar process energy requirements -- especially for electricity and on-peak demand. Electricity for building services is sometimes priced as if it were base loaded like process uses; in reality this load varies significantly according to occupancy schedules and cooling and heating loads, much as in any commercial building. Using informal field surveys, simulation studies, and detailed analyses of existing data (including utility commercial/industrial audit files), we studied the energy use of this industrial subsector through a multi-step procedure: (1) characterizing non-process building energy and power use in California industries, (2) identifying conservation and load-shaping opportunities in industrial building services, and (3) investigating industrial buildings and system design methodologies. In an earlier report, we addressed these issues by performing an extensive survey of the existing publicly available data, characterizing and comparing the building energy use in this sector. In this report, we address the above objectives by examining and analyzing energy use in two industrial case-study facilities in California. Based on the information for the case studies, we discuss the design consideration for these industrial buildings, characterize their energy use, and review their conservation and load-shaping potentials. In addition, we identify and discuss some research ideas for further investigation.

  5. Pharmacokinetic properties and in silico ADME modeling in drug discovery.

    PubMed

    Honório, Kathia M; Moda, Tiago L; Andricopulo, Adriano D

    2013-03-01

    The discovery and development of a new drug are time-consuming, difficult and expensive. This complex process has evolved from classical methods into an integration of modern technologies and innovative strategies addressed to the design of new chemical entities to treat a variety of diseases. The development of new drug candidates is often limited by initial compounds lacking reasonable chemical and biological properties for further lead optimization. Huge libraries of compounds are frequently selected for biological screening using a variety of techniques and standard models to assess potency, affinity and selectivity. In this context, it is very important to study the pharmacokinetic profile of the compounds under investigation. Recent advances have been made in the collection of data and the development of models to assess and predict pharmacokinetic properties (ADME--absorption, distribution, metabolism and excretion) of bioactive compounds in the early stages of drug discovery projects. This paper provides a brief perspective on the evolution of in silico ADME tools, addressing challenges, limitations, and opportunities in medicinal chemistry. PMID:23016542

  6. Building Better Human Service Systems: Integrating Services for Income Support and Related Programs.

    ERIC Educational Resources Information Center

    Ragan, Mark

    Service integration attempts to provide coordinated service delivery systems for the uncoordinated mix of programs such as income support programs (food stamps, Medicaid, and Temporary Assistance for Needy Families) and employment, child care, child welfare, and training programs that exist at the local level throughout the United States by…

  7. ETRMTR MECHANICAL SERVICES BUILDING, TRA653, INTERIOR. CAMERA IS INSIDE MEN'S ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR-MTR MECHANICAL SERVICES BUILDING, TRA-653, INTERIOR. CAMERA IS INSIDE MEN'S LAVATORY AND SHOWER FACING SOUTHEAST. SHOWER AND TOILET STALLS ARE IN PLACE. ROUND COMMUNAL SINK AT LEFT. INL NEGATIVE NO. 57-3652. K. Mansfield, Photographer, 7/22/1957 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  8. REACTOR SERVICES BUILDING, TRA635, INTERIOR. FIRST FLOOR. CAMERA IS ON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICES BUILDING, TRA-635, INTERIOR. FIRST FLOOR. CAMERA IS ON FIRST FLOOR, FACING SOUTH. OFFICES NOW LINE CORRIDOR. WINDOWS AT UPPER LEVEL HAVE BEEN BRICKED IN. INL NEGATIVE NO. HD46-10-2. Mike Crane, Photographer, 2/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  9. REACTOR SERVICES BUILDING, TRA635. WEST SIDE. CAMERA LOOKING NORTHEAST. MTR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICES BUILDING, TRA-635. WEST SIDE. CAMERA LOOKING NORTHEAST. MTR (TRA-603) AT LEFT OF VIEW. INL NEGATIVE NO. HD46-41-2. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  10. REACTOR SERVICES BUILDING, TRA635, INTERIOR. SECOND FLOOR. DETAIL VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REACTOR SERVICES BUILDING, TRA-635, INTERIOR. SECOND FLOOR. DETAIL VIEW OF OFFICE AREA CORRIDOR. CAMERA FACING NORTH. INL NEGATIVE NO. HD46-11-1. Mike Crane, Photographer, 2/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  11. Social Learning Networks: Build Mobile Learning Networks Based on Collaborative Services

    ERIC Educational Resources Information Center

    Huang, Jeff J. S.; Yang, Stephen J. H.; Huang, Yueh-Min; Hsiao, Indy Y. T.

    2010-01-01

    Recently, the rising of Web 2.0 has made online community gradually become popular, like Facebook, blog, etc. As a result, the online knowledge sharing network formed by interpersonal interaction is now a major character of Web 2.0, and therefore, by this trend, we try to build up a collaborative service mechanism and further set up an analysis…

  12. U.S. Fish and Wildlife Service Moves toward Net-Zero Buildings

    SciTech Connect

    2012-12-03

    First they had a vision: welcome people into a building embracing environmental stewardship on land that is steeped in history. The designers of the U.S. Fish and Wildlife Service took this vision and designed a new energy-efficient and environmentally friendly visitor center for the Assabet River National Wildlife Refuge located in Sudbury, Massachusetts.

  13. "Ayni" in the Global Village: Building Relationships of Reciprocity through International Service-Learning.

    ERIC Educational Resources Information Center

    Porter, Maureen; Monard, Kathia

    2001-01-01

    Uses the indigenous Andean concept of "ayni" to extend the idea of reciprocity as an aim of service learning. Draws on student reflections from a semester-long seminar with spring break building project in Bolivia to offer eight applications of the concept. These applications offer doorways to discuss the challenges of fostering mutual, meaningful…

  14. MTR STACK, TRA71, DETAIL OF PUMICE BLOCK SERVICE BUILDING AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR STACK, TRA-71-, DETAIL OF PUMICE BLOCK SERVICE BUILDING AT BASE OF STACK. CAMERA FACING SOUTHEAST. INL NEGATIVE NO. HD52-1-2. Mike Crane, Photographer, 5/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  15. 77 FR 58141 - Public Buildings Service; Information Collection; Art-in-Architecture Program National Artist...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... ADMINISTRATION Public Buildings Service; Information Collection; Art-in- Architecture Program National Artist... requirement regarding Art-in Architecture Program National Artist Registry (GSA Form 7437). The Art-in-Architecture Program is the result of a policy decision made in January 1963 by GSA Administrator Bernard...

  16. Conference report: a hitchhiker's guide to outsourcing ADME studies: the inside of outsourcing.

    PubMed

    Pritchard, J Fred; Anderson, Shelby R; Breuckner, Claudia; Premkumar, Noel D; Polli, Joseph W

    2013-02-01

    This report gives a summary of the key points raised during a roundtable discussion convened at the American Association of Pharmaceutical Scientists 2012 Annual Meeting and Exposition held in Chicago on 17 October 2012. The science of ADME continues to grow, as does the impact of these studies on drug development. Understanding ADME requires efforts from several scientific specialties. With reductions in pharmaceutical company R&D staff there has been a corresponding growth in CROs with the capabilities and expertise to perform ADME work. This roundtable explored the challenges inherent in understanding ADME and the issues that arise when ADME studies shift from in-house study directors to external scientists working within the business model of a CRO. Pharmaceutical industry scientists and procurement specialists can satisfy their expectations by awareness of the growing expertise within CROs and the need for open communication among all partners involved in outsourced work. PMID:23414372

  17. Identification of Absorption, Distribution, Metabolism, and Excretion (ADME) Genes Relevant to Steatosis Using a Differential Gene Expression Approach

    EPA Science Inventory

    Absorption, distribution, metabolism, and excretion (ADME) parameters represent important connections between exposure to chemicals and the activation of molecular initiating events of Adverse Outcome Pathways (AOPs) in cellular, tissue, and organ level targets. ADME parameters u...

  18. Diagnostic value of the plasmatic ADM level for early ectopic pregnancy

    PubMed Central

    Yan, Qi; Lu, Qi; Tao, Yu; Wang, Yu-Dong; Zhao, Wen-Xia

    2015-01-01

    Objective: To analyze the plasmatic ADM level in early pregnancy and to investigate the diagnostic value of ADM in early ectopic pregnancy (EP). Methods: 70 patients with EP who had menopause for 5~8 weeks were included as study group, while 155 women with normal intrauterine pregnancy were also included as control group. The correlation between ADM level and menopause weeks was statistically analyzed and ROC curve was used to identify the diagnostic value of ADM. Results: (1) In 155 cases of normal intrauterine pregnancy, the plasmatic ADM level was increased with menopause weeks in linear relationship, and the correlation coefficient (R) was 0.991 (P<0.05). In 70 patients with EP, no significant increase was found with menopause weeks and no linear relationship can be found between ADM level and menopause weeks in EP group. The correlation coefficient (R) was 0.744 (P>0.05). (2) The multiple of median of plasmatic ADM level in EP group of menopause for 8 weeks was obviously lower than the intrauterine control group (P<0.01). (3) ROC curve was used to analyze the cut-off value of ADM level in the diagnosis of EP, and the area under the ROC curve was 0.523 (P>0.05) regardless of menopause weeks, however, the area under the ROC curve was 0.702 (P<0.05) at 8 weeks after menopause with sensitivity of 53.50% and specificity of 85.00%. Conclusions: Different from normal intrauterine pregnancy, plasmatic ADM level in early EP was relatively lower and no significant increase was found with menopause weeks; further studies are still needed for plasmatic ADM level as an indicator in the early diagnosis of EP. PMID:26823809

  19. Cool Apps: Building Cryospheric Data Applications With Standards-Based Service Oriented Architecture

    NASA Astrophysics Data System (ADS)

    Collins, J. A.; Truslove, I.; Billingsley, B. W.; Oldenburg, J.; Brodzik, M.; Lewis, S.; Liu, M.

    2012-12-01

    The National Snow and Ice Data Center (NSIDC) holds a large collection of cryospheric data, and is involved in a number of informatics research and development projects aimed at improving the discoverability and accessibility of these data. To develop high-quality software in a timely manner, we have adopted a Service-Oriented Architecture (SOA) approach for our core technical infrastructure development. Data services at NSIDC are internally exposed to other tools and applications through standards-based service interfaces. These standards include OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting), various OGC (Open Geospatial Consortium) standards including WMS (Web Map Service) and WFS (Web Feature Service), ESIP (Federation of Earth Sciences Information Partners) OpenSearch, and NSIDC-specific RESTful services. By taking a standards-based approach, we are able to use off-the-shelf tools and libraries to consume, translate and broker these data services, and thus develop applications faster. Additionally, by exposing public interfaces to these services we provide valuable data services to technical collaborators; for example, NASA Reverb (http://reverb.echo.nasa.gov) uses NSIDC's WMS services. Our latest generation of web applications consume these data services directly. The most complete example of this is the Operation IceBridge Data Portal (http://nsidc.org/icebridge/portal) which depends on many of the aforementioned services, and clearly exhibits many of the advantages of building applications atop a service-oriented architecture. This presentation outlines the architectural approach and components and open standards and protocols adopted at NSIDC, demonstrates the interactions and uses of public and internal service interfaces currently powering applications including the IceBridge Data Portal, and outlines the benefits and challenges of this approach.

  20. Integrated add/drop multiplexer (ADM) using micromachined mirror

    NASA Astrophysics Data System (ADS)

    Li, J.; Zhang, Q. X.; Balasubramanian, N.; Huang, J.-M.; Liu, Ai Q.

    2001-10-01

    High speed, low insertion loss optical add/drop multiplexer (ADM) is designed and fabricated. The optical vertical micromirror is fabricated by deep dry etching, the aspect ratio reaches as high as 20. A thin aluminum film is deposited on the sidewall of the micromirror to increase the reflectivity. The anchors and pads are fabricated firstly, followed by the comb drive, micromirror and fiber grooves. Refilling technique is introduced to electrically insulate the anchors and pads from the substrate while still maintaining the mechanical support. The anchors and pads are strong enough to sustain the floating structures (micromirror and moving comb) and also assure good electrical connection to the electrostatic comb drive so that the external voltage can be applied. By improving dry etching, the finger width is only 2micrometers and the gap is only 2.5micrometers . A typical electrostatic comb drive is fabricated by the deep reactive ion etching (RIE) and underneath releasing. Folded suspension beams of 800micrometers long, 2.0 micrometers wide and 35micrometers deep are employed to support the movable micromirror. The stiffness along the desired lateral direction is 0.21N/m. Comb drive using three electrodes is employed. Its applied voltage is decreased by a ratio of 0.707 compared with that of the two electrodes system, and the switching speed is also increased. To simply the optical fiber assembly, fiber grooves are fabricated along with the other structures. This device has a typical of optical ADM that can be widely used in all optical networks. All of the processes are compatible with IC technology and can be integrated with control circuits in a single chip.

  1. Netupitant PET imaging and ADME studies in humans

    PubMed Central

    Spinelli, Tulla; Calcagnile, Selma; Giuliano, Claudio; Rossi, Giorgia; Lanzarotti, Corinna; Mair, Stuart; Stevens, Lloyd; Nisbet, Ian

    2014-01-01

    Netupitant is a new, selective NK1 receptor antagonist under development for the prevention of chemotherapy-induced nausea and vomiting. Two studies were conducted to evaluate the brain receptor occupancy (RO) and disposition (ADME) of netupitant in humans. Positron emission tomography (PET) imaging with the NK1 receptor-binding–selective tracer [11C]-GR205171 was used to evaluate the brain penetration of different doses of netupitant (100, 300, and 450 mg) and to determine the NK1-RO duration. A NK1-RO of 90% or higher was achieved with all doses in the majority of the tested brain regions at Cmax, with a long duration of RO. The netupitant minimal plasma concentration predicted to achieve a NK1-RO of 90%, C90%, in the striatum was 225 ng/mL; after administration of netupitant 300 mg, concentrations exceeded the C90%. In the ADME study, a single nominal dose of [14C]-netupitant 300 mg was used to assess its disposition. Absorption was rapid and netupitant was extensively metabolized via Phase I and II hepatic metabolism. Elimination of >90% was predicted at day 29 and was principally via hepatic/biliary route (>85%) with a minor contribution of the renal route (<5%). In conclusion, these studies demonstrate that netupitant is a potent agent targeting NK1 receptors with long lasting RO. In addition, netupitant is extensively metabolized and is mainly eliminated through the hepatic/biliary route and to a lesser extent via the kidneys. PMID:24122871

  2. Application of the Software as a Service Model to the Control of Complex Building Systems

    SciTech Connect

    Stadler, Michael; Donadee, Jon; Marnay, Chris; Lai, Judy; Mendes, Goncalo; Appen, Jan von; Mégel, Oliver; Bhattacharya, Prajesh; DeForest, Nicholas; Lai, Judy

    2011-03-18

    In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building. The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analyzed.

  3. Application of the Software as a Service Model to the Control of Complex Building Systems

    SciTech Connect

    Stadler, Michael; Donadee, Jonathan; Marnay, Chris; Mendes, Goncalo; Appen, Jan von; Megel, Oliver; Bhattacharya, Prajesh; DeForest, Nicholas; Lai, Judy

    2011-03-17

    In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building. The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analysed.

  4. Building and Using Terminology Services for the European Centre for Disease Prevention and Control

    NASA Astrophysics Data System (ADS)

    Balkányi, László; Héja, Gergely; Perucha, Cecilia Silva

    This paper describes the process of building terminology service and using domain ontology as its conceptual backbone for a European Union agency. ECDC, established in 2005, aims at strengthening Europe's defences against infectious diseases, operates a range of information services at the crossroads of different professional domains as e.g. infectious diseases, EU regulation in public health, etc. A domain ontology based vocabulary service and a tool to disseminate its content (a terminology server) was designed and implemented to ensure semantic interoperability among different information system components. Design considerations, standard selection (SKOS, OWL) choosing external references (MeSH, ICD10, SNOMED) and the services offered on the human and machine user interface are presented and lessons learned are explained.

  5. Building services cabinets as teaching material in a degree in architecture

    NASA Astrophysics Data System (ADS)

    Martín-Gómez, César; Zapata, Omayra; Zuazua, Amaia; Villanueva, Sonia; Olaizola, Paula

    2014-03-01

    The aim of this innovative educational project is to encourage students' interest in one of the most underrated fields of architecture: building services. With this material students interact with real elements and thereby understand the relationship between facilities and the building. A set of three small technical cabinets is planned. They allow for comfortable use and movement inside the building, need minimum maintenance and are easily stored. The result is an alternative concept of a mobile laboratory called a 'technical cabinet', made up of three mobile units for fire safety, electricity and the heating/cooling system. The design, content and learning systems of the cabinets confirmed the validity of the initial concept during the first year of use. A protocol has also been developed for each of the technical cabinets so that the teaching experience may be of use in other Schools of Architecture.

  6. LOFT. Containment and service building (TAN650). Room number and function ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOFT. Containment and service building (TAN-650). Room number and function of each room. Identifies type of floor, paint, walls, ceiling, doors. This is sheet 1 of a 2-page drawing. Kaiser engineers 6413-11-STEP/LOFT-650-XX. Date: October 1965. INEEL index code no. 036-650-00-486-122228 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  7. LOFT. Containment and service building (TAN650). South elevation, details, section. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOFT. Containment and service building (TAN-650). South elevation, details, section. Shows part of duct enclosure, railroad door opening, roof ventilators, shielded personnel entrance, and change room. Section F shows view from west looking toward shielding around airlock door on main floor. Kaiser engineers 6413-11-STEP/LOFT-650-A-9. Date: October 1964. INEEL index code no. 036-650-00-486-122221 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  8. LOFT. Containment and service building (TAN650). Section through north/south axis. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOFT. Containment and service building (TAN-650). Section through north/south axis. Shows basement and four additional levels of pre-amp tower, shielded roadway, chambers below reactor floor, railroad door, sumps, shielding. Section C shows basement sumps and chambers below reactor floor. Kaiser engineers 6413-11-STEP/LOFT-650-A-5. Date: October 1964. INEEL index code no. 036-650-00-486-122217 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  9. 75 FR 20364 - Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property..., identified as Key Largo Beacon Annex Site, Key Largo, FL to the U.S. Fish and Wildlife Service, Department...

  10. State services research capacity: building a state infrastructure for mental health services research.

    PubMed

    Bevilacqua, J J; Morris, J A; Pumariega, A J

    1996-12-01

    State mental health agencies in the United States manage increasingly larger and complex systems of care. This requires an increasingly sophisticated workforce and decision support infrastructure. However, with the exception of larger states with their own research and evaluation offices, few states have the necessary resources to develop these important elements. Bringing in talent from academic organizations who have research as a priority may be the preferred direction for many states. The unique approach developed in South Carolina is the first systematic collaboration between a state mental health system and a multi-institutional, inter-disciplinary academic group oriented towards developing a comprehensive, statewide infrastructure for policy-relevant mental health services research. PMID:8905225

  11. Essential Set of Molecular Descriptors for ADME Prediction in Drug and Environmental Chemical Space

    EPA Science Inventory

    Historically, the disciplines of pharmacology and toxicology have embraced quantitative structure-activity relationships (QSAR) and quantitative structure-property relationships (QSPR) to predict ADME properties or biological activities of untested chemicals. The question arises ...

  12. An interactive integrative approach to translating knowledge and building a "learning organization" in health services management.

    PubMed Central

    Chunharas, Somsak

    2006-01-01

    This paper proposes a basic approach to ensuring that knowledge from research studies is translated for use in health services management with a view towards building a "learning organization". (A learning organization is one in which the environment is structured in such a way as to facilitate learning as well as the sharing of knowledge among members or employees.) This paper highlights various dimensions that determine the complexity of knowledge translation, using the problem-solving cycle as the backbone for gaining a better understanding of how different types of knowledge interact in health services management. It is essential to use an integrated and interactive approach to ensure that knowledge from research is translated in a way that allows a learning organization to be built and that knowledge is not used merely to influence a single decision in isolation from the overall services and management of an organization. PMID:16917653

  13. Adrenomedullin 2 (ADM2) Regulates Mucin 1 at the Maternal-Fetal Interface in Human Pregnancy.

    PubMed

    Chauhan, Madhu; Balakrishnan, Meena; Chan, Rexanna; Yallampalli, Chandrasekhar

    2015-12-01

    Association of an altered expression of placental mucin 1 (MUC1) with first-trimester spontaneous abortion and its regulation in placenta by an invasion-promoting peptide, adrenomedullin 2 (ADM2), is not known. The objective of this study was to assess 1) the association of MUC1 mRNA expression in the placental villi and decidua with first-trimester spontaneous abortion, 2) the effects of ADM2 on the expression of MUC1 in trophoblast cells in the presence or absence of hypoxia, 3) the effects of ADM2 on expression of MUC1 in decidual stromal cells (DSCs), and 4) if ADM2 regulates the expression of MUC1 and MMP2 protein in trophoblastic spheroids. Data demonstrate that 1) expression of MUC1 mRNA in villous tissue is higher in spontaneous abortion compared to age-matched electively terminated pregnancies (P > 0.05), 2) ADM2 decreases the expression of MUC1 mRNA and protein in trophoblast cells and spheroids with concomitant increases in MMP2 immunoreactivity in the spheroids, 3) ADM2 decreases hypoxia-induced increases in MUC1 immunoreactivity in trophoblast cells, 4) decidual MUC1 mRNA expression is lower in spontaneous compared to elective abortions (P < 0.05), and 5) DSCs express MUC1 mRNA and protein and ADM2 decreases the expression of MUC1 mRNA and protein in DSCs. Taken together, this study demonstrates that first-trimester spontaneous abortion is associated with increases in MUC1 expression in villi and decreases in the decidual tissues, and suggests that ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 and decreasing MUC1 expression to facilitate trophoblast invasion. PMID:26510869

  14. EPOS-Seismology: building the Thematic Core Service for Seismology during the EPOS Implementation Phase

    NASA Astrophysics Data System (ADS)

    Haslinger, Florian; EPOS Seismology Consortium, the

    2015-04-01

    After the successful completion of the EPOS Preparatory Phase, the community of European Research Infrastructures in Seismology is now moving ahead with the build-up of the Thematic Core Service (TCS) for Seismology in EPOS, EPOS-Seismology. Seismology is a domain where European-level infrastructures have been developed since decades, often supported by large-scale EU projects. Today these infrastructures provide services to access earthquake waveforms (ORFEUS), parameters (EMSC) and hazard data and products (EFEHR). The existing organizations constitute the backbone of infrastructures that also in future will continue to manage and host the services of the TCS EPOS-Seismology. While the governance and internal structure of these organizations will remain active, and continue to provide direct interaction with the community, EPOS-Seismology will provide the integration of these within EPOS. The main challenge in the build-up of the TCS EPOS-Seismology is to improve and extend these existing services, producing a single framework which is technically, organizationally and financially integrated with the EPOS architecture, and to further engage various kinds of end users (e.g. scientists, engineers, public managers, citizen scientists). On the technical side the focus lies on four major tasks: - the construction of the next generation software architecture for the European Integrated (waveform) Data Archive EIDA, developing advanced metadata and station information services, fully integrate strong motion waveforms and derived parametric engineering-domain data, and advancing the integration of mobile (temporary) networks and OBS deployments in EIDA; - the further development and expansion of services to access seismological products of scientific interest as provided by the community by implementing a common collection and development (IT) platform, improvements in the earthquake information services e.g. by introducing more robust quality indicators and diversifying

  15. TIG WELDER LOCATED IN THE CLEAN ROOM OF THE TECHNICAL SERVICES BUILDING TSB - THE INERT GAS WELDING

    NASA Technical Reports Server (NTRS)

    1963-01-01

    TIG WELDER LOCATED IN THE CLEAN ROOM OF THE TECHNICAL SERVICES BUILDING TSB - THE INERT GAS WELDING FACILITY IS USED FOR WELDING REFRACTORY METALS IN CONNECTION WITH THE COLUMBIUM LIQUID SODIUM LOOP PROJECT

  16. 75 FR 2144 - Public Buildings Service; Submission for OMB Review; Art-in-Architecture Program National Artist...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... comments was published in the Federal Register at 74 FR 31278, on June 30, 2009. No comments were received... Harrison, Public Buildings Service, Office of the Chief Architect, Art-in-Architecture Program, 1800...

  17. GPS Space Service Volume: Ensuring Consistent Utility Across GPS Design Builds for Space Users

    NASA Technical Reports Server (NTRS)

    Bauer, Frank H.; Parker, Joel Jefferson Konkl; Valdez, Jennifer Ellen

    2015-01-01

    GPS availability and signal strength originally specified for users on or near surface of Earth with transmitted power levels specified at edge-of-Earth, 14.3 degrees. Prior to the SSV specification, on-orbit performance of GPS varied from block build to block build (IIA, IIRM, IIF) due to antenna gain and beam width variances. Unstable on-orbit performance results in significant risk to space users. Side-lobe signals, although not specified, were expected to significantly boost GPS signal availability for users above the constellation. During GPS III Phase A, NASA noted significant discrepancies in power levels specified in GPS III specification documents, and measured on-orbit performance. To stabilize the signal for high altitude space users, NASA DoD team in 2003-2005 led the creation of new Space Service Volume (SSV) definition and specifications.

  18. Formulation of Multiple Diffraction by Trees and Buildings for Radio Propagation Predictions for Local Multipoint Distribution Service

    PubMed Central

    Zhang, Wei

    1999-01-01

    This paper presents a closed-form expression for multiple forward diffraction by rows of tree canopies and buildings applicable to the propagation predictions at centimeter and millimeter wavelengths for local multipoint distribution service (LMDS). The expression is derived from the uniform geometrical theory of diffraction and physical optics, as well as from some existing models for vegetation and buildings. When the transmitter antennas are sufficiently high, the attenuation of the buildings varies around the value of free space and the building effect is negligible, because a line-of-sight (LOS) propagation path between transmitter and over building-rooftop receiver antennas exists and plays a major role. The tree canopies which extend above the building rooftop heights block the LOS propagation path and cause additional signal attenuation. An existing study of the LMDS radio channel based on measurements came to the same conclusion. The attenuation effect of the buildings is significant if the transmitter antennas are not high enough.

  19. The impact of the different payment options on the medical services clients' satisfaction building process

    NASA Astrophysics Data System (ADS)

    Skowron, Łukasz; Gąsior, Marcin; Sak-Skowron, Monika

    2014-12-01

    Both the scientific bodies as well as business practitioners over the past few years have concentrated their efforts in the field of marketing and management primarily around the concept of customer, wanting to know more about him/her and trying to understand their behaviour so that their market activities can more easily be influenced and shaped. In today's market, the customer bases the purchase-decision-making process on choosing a good/service that will give him/her the greatest satisfaction, a subjective, positive experience, which is an emotional reaction to the perceived value. Its level is a result of the comparison between the level of expectations arising from past experience, obtained information and promises, and the perception of experienced situation. In the empirical part of the manuscript, the authors present the main differences in the process of building customer satisfaction and loyalty for two groups of patients: those using prepaid medical services and those who pay for their services each time. Reported results refer to research carried out by the authors between August and October 2012 in the city of Warsaw (Poland) with use of the Structural Equation Modeling analysis. The study was conducted via paper surveys, on a sample of 1590 respondents who were the patients of selected medical organizations. The study demonstrated, using two, separate models, that among aforementioned groups of patients, the evaluation of health services proceeds in quite a different way. This indicates significant implications, of marketing and management character in the field of communication and building long-term patient-organization relationships. Medical establishments wanting to manage effectively their relationships with current and potential customers need to understand the nature of the different groups of patients and be able to adjust the scope and form of marketing activities to their different expectations and preferences.

  20. NSIDC Metadata Improvements: Building the foundation for interoperability, discovery, and services

    NASA Astrophysics Data System (ADS)

    Leon, A.; Collins, J. A.; Billingsley, B. W.; Jasiak, E.

    2011-12-01

    The National Snow and Ice Data Center (NSIDC) is actively engaged in efforts to improve metadata acquisition, creation, management, and dissemination. We are replacing a collection of historical databases with an enterprise database (EDB) to manage file and service metadata critical to NSIDC's continued advancement in the areas of data management, stewardship, discovery, analysis and dissemination. Leveraging PostGIS and the ISO 19115 metadata standards, the database will serve as the authoritative, consistent, and extensible representation of NSIDC data holdings. The EDB will support multiple applications, and these applications may present interfaces designed for either human or machine interaction. To serve in this critical role, the content of the EDB must be valid and reliable. Current efforts are focused on developing a user interface to support the input and maintenance of metadata content. Future efforts will include the addition of automated (batch) metadata ingest. Ultimately, the EDB content and services built to interface with the EDB will be leveraged to automate and improve our existing metadata workflows. A solid metadata foundation is critical to the advancement of discovery and services. Building upon a well established standard, like ISO 19115, enables efficient translation to various metadata schemas, support of rich user interfaces, and promotes interoperability with external data services.

  1. Using Multimedia Technology to Build a Community of Practice: Pre-Service Teachers' and Digital Storytelling in South Africa

    ERIC Educational Resources Information Center

    Chigona, Agnes

    2013-01-01

    Employing the theory of Community of Practice (CoP), this paper shows how the use of multimedia led a group of pre-service teachers to build a community of practice in the process of completing their individual digital stories for assessment. The paper is focused on a group of diverse pre-service teachers doing their final year at a teacher…

  2. A Selective Bibliography of Building Environment and Service Systems with Particular Reference to Computer Applications. Computer Report CR20.

    ERIC Educational Resources Information Center

    Forwood, Bruce S.

    This bibliography has been produced as part of a research program attempting to develop a new approach to building environment and service systems design using computer-aided design techniques. As such it not only classifies available literature on the service systems themselves, but also contains sections on the application of computers and…

  3. Improved ADM1 model for anaerobic digestion process considering physico-chemical reactions.

    PubMed

    Zhang, Yang; Piccard, Sarah; Zhou, Wen

    2015-11-01

    The "Anaerobic Digestion Model No. 1" (ADM1) was modified in the study by improving the bio-chemical framework and integrating a more detailed physico-chemical framework. Inorganic carbon and nitrogen balance terms were introduced to resolve the discrepancies in the original bio-chemical framework between the carbon and nitrogen contents in the degraders and substrates. More inorganic components and solids precipitation processes were included in the physico-chemical framework of ADM1. The modified ADM1 was validated with the experimental data and used to investigate the effects of calcium ions, magnesium ions, inorganic phosphorus and inorganic nitrogen on anaerobic digestion in batch reactor. It was found that the entire anaerobic digestion process might exist an optimal initial concentration of inorganic nitrogen for methane gas production in the presence of calcium ions, magnesium ions and inorganic phosphorus. PMID:26253912

  4. Protocol for the prevention and management of complications related to ADM implant-based breast reconstructions.

    PubMed

    Citron, Isabelle; Dower, Rory; Ho-Asjoe, Mark

    2016-01-01

    Acellular dermal matrix (ADM) implant-based reconstructions have transformed direct-to-implant breast reconstruction (DTI). But like all surgery, it is not deplete of complications such as seroma, infections and wound healing problems. These are cited with varying frequencies in the literature. With increased experience and through a series of measures instituted to minimize complications, we have been able to improve outcomes for our patients. We report our technical refinements for prevention of ADM reconstruction associated complications including patient selection, implant selection, drains, dressing and our post operative antibiotic regime. We also outline our protocol for the management of ADM associated complications including seroma, simple and complex infection and red breast syndrome, such that the sequelae of complications are minimized and patients achieve a better long-term outcome. PMID:26816672

  5. Protocol for the prevention and management of complications related to ADM implant-based breast reconstructions

    PubMed Central

    Citron, Isabelle; Dower, Rory; Ho-Asjoe, Mark

    2016-01-01

    Acellular dermal matrix (ADM) implant-based reconstructions have transformed direct-to-implant breast reconstruction (DTI). But like all surgery, it is not deplete of complications such as seroma, infections and wound healing problems. These are cited with varying frequencies in the literature. With increased experience and through a series of measures instituted to minimize complications, we have been able to improve outcomes for our patients. We report our technical refinements for prevention of ADM reconstruction associated complications including patient selection, implant selection, drains, dressing and our post operative antibiotic regime. We also outline our protocol for the management of ADM associated complications including seroma, simple and complex infection and red breast syndrome, such that the sequelae of complications are minimized and patients achieve a better long-term outcome. PMID:26816672

  6. Well-posed ADM equivalent of the Bondi-Sachs problem

    SciTech Connect

    Frittelli, Simonetta

    2006-06-15

    Every well-posed hyperbolic problem has an associated characteristic representation. In the case of the Einstein equations, traditionally, characteristic problems have been stated in the Bondi-Sachs form, whereas initial-value problems have been represented in the ADM form, both being looked upon as independent versions of the Einstein equations. Under the restriction of spherical symmetry, we provide an ADM version of the Einstein equations that functions as the initial-value representation of the Bondi-Sachs equations. The ADM version allows us to interpret the Bondi-Sachs variables precisely in terms of characteristic fields of the Cauchy problem. The Bondi-Sachs version thus leads us to a version of the Cauchy problem that is first order in time (with no need for reduction) and automatically well posed.

  7. Building thematic and integrated services for solid Earth sciences: the EPOS integrated approach

    NASA Astrophysics Data System (ADS)

    Cocco, Massimo; Consortium, Epos

    2016-04-01

    EPOS has been designed with the vision of creating a pan-European infrastructure for solid Earth science to support a safe and sustainable society. In accordance with this scientific vision, the EPOS mission is to integrate the diverse and advanced European Research Infrastructures for solid Earth science relying on new e-science opportunities to monitor and unravel the dynamic and complex Earth System. EPOS will enable innovative multidisciplinary research for a better understanding of the Earth's physical and chemical processes that control earthquakes, volcanic eruptions, ground instability and tsunami as well as the processes driving tectonics and Earth's surface dynamics. To accomplish its mission, EPOS is engaging different stakeholders, not limited to scientists, to allow the Earth sciences to open new horizons in our understanding of the planet. EPOS also aims at contributing to prepare society for geo-hazards and to responsibly manage the exploitation of geo-resources. Through integration of data, models and facilities, EPOS will allow the Earth science community to make a step change in developing new concepts and tools for key answers to scientific and socio-economic questions concerning geo-hazards and geo-resources as well as Earth sciences applications to the environment and human welfare. A long-term integration plan is necessary to accomplish the EPOS mission. EPOS is presently in its implementation phase further extending its pan-European dimension. The EPOS Implementation Phase builds on the achievements of the successful EPOS Preparatory Phase project and consists of two key activities: the legal establishment of the EPOS-ERIC and the EPOS IP project. The EPOS implementation phase will last from 2015 to 2019. Key objectives of the project are: implementing Thematic Core Services (TCS), the domain-specific service hubs for coordinating and harmonizing national resources/plans with the European dimension of EPOS; building the Integrated Core

  8. Algebraic dynamic multilevel (ADM) method for fully implicit simulations of multiphase flow in porous media

    NASA Astrophysics Data System (ADS)

    Cusini, Matteo; van Kruijsdijk, Cor; Hajibeygi, Hadi

    2016-06-01

    This paper presents the development of an algebraic dynamic multilevel method (ADM) for fully implicit simulations of multiphase flow in homogeneous and heterogeneous porous media. Built on the fine-scale fully implicit (FIM) discrete system, ADM constructs a multilevel FIM system describing the coupled process on a dynamically defined grid of hierarchical nested topology. The multilevel adaptive resolution is determined at each time step on the basis of an error criterion. Once the grid resolution is established, ADM employs sequences of restriction and prolongation operators in order to map the FIM system across the considered resolutions. Several choices can be considered for prolongation (interpolation) operators, e.g., constant, bilinear and multiscale basis functions, all of which form partition of unity. The adaptive multilevel restriction operators, on the other hand, are constructed using a finite-volume scheme. This ensures mass conservation of the ADM solutions, and as such, the stability and accuracy of the simulations with multiphase transport. For several homogeneous and heterogeneous test cases, it is shown that ADM applies only a small fraction of the full FIM fine-scale grid cells in order to provide accurate solutions. The sensitivity of the solutions with respect to the employed fraction of grid cells (determined automatically based on the threshold value of the error criterion) is investigated for all test cases. ADM is a significant step forward in the application of dynamic local grid refinement methods, in the sense that it is algebraic, allows for systematic mapping across different scales, and applicable to heterogeneous test cases without any upscaling of fine-scale high resolution quantities. It also develops a novel multilevel multiscale method for FIM multiphase flow simulations in natural subsurface formations.

  9. New Deep Dermal ADM Incorporates Well in Case Series of Complex Breast Reconstruction Patients.

    PubMed

    Wilson, Henry Benjamin

    2015-05-01

    Breast cancer patients with significant comorbidities present reconstructive challenges due to a predictably high complication rate. During expander-based breast reconstruction, human acellular dermal matrix (ADM) is often used to prevent pectoralis muscle retraction, facilitate early expansion, and improve cosmetic outcome. Device infection and chronic seroma have been correlated to the addition of the graft by some large database reports but not others. This study describes the first reported experience with a new deep dermal ADM, FlexHD® Pliable™ (MTF, Edison, NJ). Sixteen breasts in 10 consecutive patients identified retrospectively and followed prospectively had immediate expander-based breast reconstruction utilizing the new ADM. Patient comorbidities were catalogued, complications were recorded, and overall reconstructive success was assessed. At implant exchange, the ADM was examined for tissue ingrowth and biopsied for histologic examination. All 16 breasts had successful reconstructions. Two breasts (12.5%) developed device infection, requiring removal and later replacement of the expander. One breast (6.7%) developed chronic seroma, also requiring expander removal and later replacement. All the complicated patients had significant comorbidities, including obesity in all 3. At expander removal, the FlexHD Pliable showed near-complete visual tissue incorporation in 14 of 16 breasts (88%). This case series demonstrates significant reconstructive success in challenging patients utilizing a novel ADM. Visual and histologic assessment of tissue ingrowth into the graft suggests the high rate of complication may be due to patient comorbidities rather than addition of ADM. Additional experience is needed to confirm and the study is ongoing. PMID:26020380

  10. Principles and techniques in the design of ADMS+. [advanced data-base management system

    NASA Technical Reports Server (NTRS)

    Roussopoulos, Nick; Kang, Hyunchul

    1986-01-01

    'ADMS+/-' is an advanced data base management system whose architecture integrates the ADSM+ mainframe data base system with a large number of work station data base systems, designated ADMS-; no communications exist between these work stations. The use of this system radically decreases the response time of locally processed queries, since the work station runs in a single-user mode, and no dynamic security checking is required for the downloaded portion of the data base. The deferred update strategy used reduces overhead due to update synchronization in message traffic.

  11. Supporting UK adaptation: building services for the next set of UK climate projections

    NASA Astrophysics Data System (ADS)

    Fung, Fai; Lowe, Jason

    2016-04-01

    As part of the Climate Change Act 2008, the UK Government sets out a national adaptation programme to address the risks and opportunities identified in a national climate change risk assessment (CCRA) every five years. The last risk assessment in 2012 was based on the probabilistic projections for the UK published in 2009 (UKCP09). The second risk assessment will also use information from UKCP09 alongside other evidence on climate projections. However, developments in the science of climate projeciton, and evolving user needs (based partly on what has been learnt about the diverse user requirements of the UK adaptation community from the seven years of delivering and managing UKCP09 products, market research and the peer-reviewed literature) suggest now is an appropriate time to update the projections and how they are delivered. A new set of UK climate projections are now being produced to upgrade UKCP09 to reflect the latest developments in climate science, the first phase of which will be delivered in 2018 to support the third CCRA. A major component of the work is the building of a tailored service to support users of the new projections during their development and to involve users in key decisions so that the projections are of most use. We will set out the plan for the new climate projections that seek to address the evolving user need. We will also present a framework which aims to (i) facilitate the dialogue between users, boundary organisations and producers, reflecting their different decision-making roles (ii) produce scientifically robust, user-relevant climate information (iii) provide the building blocks for developing further climate services to support adaptation activities in the UK.

  12. Lessons Learned in Building VO Resources: Binding Together Several VO Standards into an Operational Service

    NASA Astrophysics Data System (ADS)

    Chilingarian, I.; Bonnarel, F.; Louys, M.; Le Sidaner, P.

    2012-09-01

    The International Virtual Observatory Alliance (IVOA) developed numerous interoperability standards during the last several years. Most of them are quite simple to implement from the technical point of view and even contain “SIMPLE” in the title. Does it mean that it is also simple to build a working VO resource using those standards? Yes and no. “Yes” because the standards are indeed simple, and “no” because usually one needs to implement a lot more than it was thought in the beginning of the project so the time management of the team becomes difficult. In our presentation we will start with a basic case of a simple spectral data collection. Then we will describe several examples of “small” technologically advanced VO resources built in CDS and VO-Paris and will show that many standards are hidden from managers' eyes at the initial stage of the project development. The projects will be: (1) the GalMer database providing access to the results of numerical simulations of galaxy interactions; (2) the full spectrum fitting service that allows one to extract internal kinematics and stellar populations from spectra of galaxies available in the VO. We conclude that: (a) with the existing set of IVOA standards one can already build very advanced VO-enabled archives and tools useful for scientists; (b) managers have to be very careful when estimating the project development timelines for VO-enabled resources.

  13. CEMS: Building a Cloud-Based Infrastructure to Support Climate and Environmental Data Services

    NASA Astrophysics Data System (ADS)

    Kershaw, P. J.; Curtis, M.; Pechorro, E.

    2012-04-01

    CEMS, the facility for Climate and Environmental Monitoring from Space, is a new joint collaboration between academia and industry to bring together their collective expertise to support research into climate change and provide a catalyst for growth in related Earth Observation (EO) technologies and services in the commercial sector. A recent major investment by the UK Space Agency has made possible the development of a dedicated facility at ISIC, the International Space Innovation Centre at Harwell in the UK. CEMS has a number of key elements: the provision of access to large-volume EO and climate datasets co-located with high performance computing facilities; a flexible infrastructure to support the needs of research projects in the academic community and new business opportunities for commercial companies. Expertise and tools for scientific data quality and integrity are another essential component, giving users confidence and transparency in its data, services and products. Central to the development of this infrastructure is the utilisation of cloud-based technology: multi-tenancy and the dynamic provision of resources are key characteristics to exploit in order to support the range of organisations using the facilities and the varied use cases. The hosting of processing services and applications next to the data within the CEMS facility is another important capability. With the expected exponential increase in data volumes within the climate science and EO domains it is becoming increasingly impracticable for organisations to retrieve this data over networks and provide the necessary storage. Consider for example, the factor of o20 increase in data volumes expected for the ESA Sentinel missions over the equivalent Envisat instruments. We explore the options for the provision of a hybrid community/private cloud looking at offerings from the commercial sector and developments in the Open Source community. Building on this virtualisation layer, a further core

  14. The EPOS Implementation Phase: building thematic and integrated services for solid Earth sciences

    NASA Astrophysics Data System (ADS)

    Cocco, Massimo; Epos Consortium, the

    2015-04-01

    The European Plate Observing System (EPOS) has a scientific vision and approach aimed at creating a pan-European infrastructure for Earth sciences to support a safe and sustainable society. To follow this vision, the EPOS mission is integrating a suite of diverse and advanced Research Infrastructures (RIs) in Europe relying on new e-science opportunities to monitor and understand the dynamic and complex Earth system. To this goal, the EPOS Preparatory Phase has designed a long-term plan to facilitate integrated use of data and products as well as access to facilities from mainly distributed existing and new research infrastructures for solid Earth Science. EPOS will enable innovative multidisciplinary research for a better understanding of the Earth's physical processes that control earthquakes, volcanic eruptions, ground instability and tsunami as well as the processes driving tectonics and Earth surface dynamics. Through integration of data, models and facilities EPOS will allow the Earth Science community to make a step change in developing new concepts and tools for key answers to scientific and socio-economic questions concerning geo-hazards and geo-resources as well as Earth sciences applications to the environment and to human welfare. Since its conception EPOS has been built as "a single, Pan-European, sustainable and distributed infrastructure". EPOS is, indeed, the sole infrastructure for solid Earth Science in ESFRI and its pan-European dimension is demonstrated by the participation of 23 countries in its preparatory phase. EPOS is presently moving into its implementation phase further extending its pan-European dimension. The EPOS Implementation Phase project (EPOS IP) builds on the achievements of the successful EPOS preparatory phase project. The EPOS IP objectives are synergetic and coherent with the establishment of the new legal subject (the EPOS-ERIC in Italy). EPOS coordinates the existing and new solid Earth RIs within Europe and builds the

  15. Analysis of energy use in building services of the industrial sector in California: Two case studies. Final report

    SciTech Connect

    Akbari, H.; Sezgen, O.

    1991-09-01

    Energy-use patterns in many of California`s fastest-growing industries are not typical of the existing mix of industries in the US. Many California firms operate small- and medium-sized facilities housed in buildings used simultaneously or interchangeably over time for commercial (office, retail, warehouse) and industrial activities. In these industrial subsectors, the energy required for building services (providing occupant comfort and necessities like lighting, HVAC, office equipment, computers, etc.) may be at least as important as the more familiar process energy requirements -- especially for electricity and on-peak demand. Electricity for building services is sometimes priced as if it were base loaded like process uses; in reality this load varies significantly according to occupancy schedules and cooling and heating loads, much as in any commercial building. Using informal field surveys, simulation studies, and detailed analyses of existing data (including utility commercial/industrial audit files), we studied the energy use of this industrial subsector through a multi-step procedure: (1) characterizing non-process building energy and power use in California industries, (2) identifying conservation and load-shaping opportunities in industrial building services, and (3) investigating industrial buildings and system design methodologies. In an earlier report, we addressed these issues by performing an extensive survey of the existing publicly available data, characterizing and comparing the building energy use in this sector. In this report, we address the above objectives by examining and analyzing energy use in two industrial case-study facilities in California. Based on the information for the case studies, we discuss the design consideration for these industrial buildings, characterize their energy use, and review their conservation and load-shaping potentials. In addition, we identify and discuss some research ideas for further investigation.

  16. Building a Comprehensive System of Services to Support Adults Living with Long-Term Mechanical Ventilation

    PubMed Central

    Leasa, David; Elson, Stephen

    2016-01-01

    Background. Increasing numbers of individuals require long-term mechanical ventilation (LTMV) in the community. In the South West Local Health Integration Network (LHIN) in Ontario, multiple organizations have come together to design, build, and operate a system to serve adults living with LTMV. Objective. The goal was to develop an integrated approach to meet the health and supportive care needs of adults living with LTMV. Methods. The project was undertaken in three phases: System Design, Implementation Planning, and Implementation. Results. There are both qualitative and quantitative evidences that a multiorganizational system of care is now operational and functioning in a way that previously did not exist. An Oversight Committee and an Operations Management Committee currently support the system of services. A Memorandum of Understanding has been signed by the participating organizations. There is case-based evidence that hospital admissions are being avoided, transitions in care are being thoughtfully planned and executed collaboratively among service providers, and new roles and responsibilities are being accepted within the overall system of care. Conclusion. Addressing the complex and variable needs of adults living with LTMV requires a systems response involving the full continuum of care. PMID:27445527

  17. Building a Comprehensive System of Services to Support Adults Living with Long-Term Mechanical Ventilation.

    PubMed

    Leasa, David; Elson, Stephen

    2016-01-01

    Background. Increasing numbers of individuals require long-term mechanical ventilation (LTMV) in the community. In the South West Local Health Integration Network (LHIN) in Ontario, multiple organizations have come together to design, build, and operate a system to serve adults living with LTMV. Objective. The goal was to develop an integrated approach to meet the health and supportive care needs of adults living with LTMV. Methods. The project was undertaken in three phases: System Design, Implementation Planning, and Implementation. Results. There are both qualitative and quantitative evidences that a multiorganizational system of care is now operational and functioning in a way that previously did not exist. An Oversight Committee and an Operations Management Committee currently support the system of services. A Memorandum of Understanding has been signed by the participating organizations. There is case-based evidence that hospital admissions are being avoided, transitions in care are being thoughtfully planned and executed collaboratively among service providers, and new roles and responsibilities are being accepted within the overall system of care. Conclusion. Addressing the complex and variable needs of adults living with LTMV requires a systems response involving the full continuum of care. PMID:27445527

  18. The effects of building design on hazard of first service in Norwegian dairy cows.

    PubMed

    Martin, A D; Kielland, C; Nelson, S T; Østerås, O

    2015-12-01

    Reproductive inefficiency is one of the major production and economic constraints on modern dairy farms. The environment affects onset of ovarian activity in a cow postcalving and influences estrus behavior, which in turn affects a stockperson's ability to inseminate her at the correct time. This study used survival analysis to investigate effects of building design and animal factors on the postpartum hazard of first service (HFS) in freestall-housed Norwegian Red cows. The study was performed on 232 Norwegian dairy farms between 2004 and 2007. Data were obtained through on farm measurements and by accessing the Norwegian Dairy Herd Recording System. The final data set contained data on 38,436 calvings and 27,127 services. Univariate Cox proportional hazard analyses showed that herd size and milk yield were positively associated with HFS. Total free accessible area and free accessible area available per cow year were positively associated with the HFS, as was the number of freestalls available per cow. Cows housed on slatted floors had a lower HFS than those housed on solid floors. Conversely, cows housed on rubber floors had a higher HFS than cows on concrete floors. Dead-ending alleyways reduced the hazard of AI after calving. A multivariable Cox proportional hazards model, accounting for herd management by including a frailty term for herd, showed relationships between hazard of postpartum service and explanatory variables. Animals in herds with more than 50 cows had a higher HFS [hazard ratio (HR)=3.0] compared with those in smaller herds. The HFS was also higher (HR=4.3) if more than 8.8 m(2) of space was available per cow year compared with herds in which animals had less space. The HFS after calving increased with parity (parity 2 HR=0.5, parity ≥3 HR=1.7), and was reduced if a lactation began with dystocia (HR=0.82) or was a breed other than Norwegian Red (HR=0.2). The frailty term, herd, was large and highly significant indicating a significant

  19. ADM. Water System Pump House (TAN610). Elevations, plan, and sections. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ADM. Water System Pump House (TAN-610). Elevations, plan, and sections. Ralph M. Parsons 902-2-ANP-610-A 74. Date: February 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0610-00-693-106739 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  20. Prediction of In-silico ADME Properties of 1,2-O-Isopropylidene Aldohexose Derivatives

    PubMed Central

    Kovačević, Strahinja Z; Jevrić, Lidija R; Podunavac Kuzmanović, Sanja O; Lončar, Eva S

    2014-01-01

    Retention behaviour of molecules mostly depends on their chemical structure. Retention data of biologically active molecules could be an indirect relationship between their structure and biological or pharmacological activity, since the molecular structure affects their behaviour in all pharmacokinetic stages. In the present paper, retention parameters (RM0) of biologically active 1,2-O-isopropylidene aldohexose derivatives, obtained by normal-phase thin-layer chromatography (NP TLC), were correlated with selected physicochemical properties relevant to pharmacokinetics, i.e. absorption, distribution, metabolism, and elimination (ADME) properties. Conducted correlation analysis showed high dependence between RM0 and blood brain barrier penetration, skin permeability, enzyme inhibition, binding affinity to nuclear receptor ligand and G protein-coupled receptors, as well as lipophilicity (expressed as Hansh-Leo’s parameter Clog P). The statistical validity of the established polynomial dependence of the second degree between RM0 and mentioned ADME properties was confirmed by standard statistical measures and leave-one-out cross-validation method. On the basis of in-silico calculated ADME properties and retention data, the similarity between studied molecules was examined using principal component analysis (PCA). The obtained results indicate the possibility of predicting ADME properties of studied compounds on the basis of their retention data (RM0). These preliminary results could be treated as guideline for selecting new 1,2-O-isopropylidene aldohexose derivatives as drug candidates. PMID:25276190

  1. ADM. Water well pump houses (TAN612 and TAN613). Plans, elevations, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ADM. Water well pump houses (TAN-612 and TAN-613). Plans, elevations, floor and other details. Ralph M. Parsons 902-2-ANP-612-613-A S & P 82. Date: December 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0612-00-693-106743 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  2. ADM. Pump House (TAN612) for well no. 1 as completed. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ADM. Pump House (TAN-612) for well no. 1 as completed. It is identical to pump house (TAN-613) for well no. 2, which is not shown in this report. Date: October 19, 1954. INEEL negative no. 12576 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  3. Transforming Service Employees and Climate: A Multilevel, Multisource Examination of Transformational Leadership in Building Long-Term Service Relationships

    ERIC Educational Resources Information Center

    Liao, Hui; Chuang, Aichia

    2007-01-01

    This longitudinal field study integrates the theories of transformational leadership (TFL) and relationship marketing to examine how TFL influences employee service performance and customer relationship outcomes by transforming both (at the micro level) the service employees' attitudes and (at the macro level) the work unit's service climate.…

  4. The Intelcities Community of Practice: The Capacity-Building, Co-Design, Evaluation, and Monitoring of E-Government Services

    ERIC Educational Resources Information Center

    Deakin, Mark; Lombardi, Patrizia; Cooper, Ian

    2011-01-01

    The paper examines the IntelCities Community of Practice (CoP) supporting the development of the organization's capacity-building, co-design, monitoring, and evaluation of e-government services. It begins by outlining the IntelCities CoP and goes on to set out the integrated model of electronically enhanced government (e-government) services…

  5. Building a Third Space: How Academic Language Knowledge Helps Pre-Service Teachers Develop Content Literacy Practices

    ERIC Educational Resources Information Center

    Sussbauer, Erik J.

    2013-01-01

    Though attention to academic language is a key component of the Teacher Performance Assessment and the new Common Core Standards, little has been researched regarding how pre-service teachers build academic language knowledge and integrate it into their practice teaching experience. This study focuses on the construction and delivery of academic…

  6. The Role of Community-Based Playgroups in Building Relationships between Pre-Service Teachers, Families and the Community

    ERIC Educational Resources Information Center

    McFarland-Piazza, Laura; Lord, Alison; Smith, Melissa; Downey, Belinda

    2012-01-01

    The purpose of this study was to explore how connections between families, communities and educators can be facilitated in teacher education courses through the use of playgroups. Barriers to building relationships, as well as the perceived benefits of these relationships to families and pre-service teachers, were also explored. Participants were…

  7. 77 FR 73657 - Public Buildings Service; Submission for OMB Review; Art-in-Architecture Program National Artist...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... regarding Art-in Architecture Program National Artist Registry (GSA Form 7437). A notice was published in the Federal Register at 77 FR 58141, on September 19, 2012. No comments were received. The Art-in... ADMINISTRATION Public Buildings Service; Submission for OMB Review; Art-in- Architecture Program National...

  8. The African Field Epidemiology Network-Networking for effective field epidemiology capacity building and service delivery

    PubMed Central

    Gitta, Sheba Nakacubo; Mukanga, David; Babirye, Rebecca; Dahlke, Melissa; Tshimanga, Mufuta; Nsubuga, Peter

    2011-01-01

    Networks are a catalyst for promoting common goals and objectives of their membership. Public Health networks in Africa are crucial, because of the severe resource limitations that nations face in dealing with priority public health problems. For a long time, networks have existed on the continent and globally, but many of these are disease-specific with a narrow scope. The African Field Epidemiology Network (AFENET) is a public health network established in 2005 as a non-profit networking alliance of Field Epidemiology and Laboratory Training Programs (FELTPs) and Field Epidemiology Training Programs (FETPs) in Africa. AFENET is dedicated to helping ministries of health in Africa build strong, effective and sustainable programs and capacity to improve public health systems by partnering with global public health experts. The Network's goal is to strengthen field epidemiology and public health laboratory capacity to contribute effectively to addressing epidemics and other major public health problems in Africa. AFENET currently networks 12 FELTPs and FETPs in sub-Saharan Africa with operations in 20 countries. AFENET has a unique tripartite working relationship with government technocrats from human health and animal sectors, academicians from partner universities, and development partners, presenting the Network with a distinct vantage point. Through the Network, African nations are making strides in strengthening their health systems. Members are able to: leverage resources to support field epidemiology and public health laboratory training and service delivery notably in the area of outbreak investigation and response as well as disease surveillance; by-pass government bureaucracies that often hinder and frustrate development partners; and consolidate efforts of different partners channelled through the FELTPs by networking graduates through alumni associations and calling on them to offer technical support in various public health capacities as the need arises

  9. Marine Science Building Dedicated

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Officials cut the ribbon during dedication ceremonies of the George A. Knauer Marine Science Building on Oct. 17 at NASA Stennis Space Center (SSC). The $2.75 million facility, the first building at the test site funded by the state of Mississippi, houses six science labs, classrooms and office space for 40 faculty and staff. Pictured are, from left, Rear Adm. Thomas Donaldson, commander of the Naval Meteorology and Oceanography Command; SSC Assistant Director David Throckmorton; Dr. George A. Knauer, founder of the Center of Marine Science at the University of Southern Mississippi (USM); Lt. Gov. Amy Tuck; and USM President Dr. Shelby Thames.

  10. Porous nano-hydroxyapatite/collagen scaffold containing drug-loaded ADM-PLGA microspheres for bone cancer treatment.

    PubMed

    Rong, Zi-Jie; Yang, Lian-Jun; Cai, Bao-Ta; Zhu, Li-Xin; Cao, Yan-Lin; Wu, Guo-Feng; Zhang, Zan-Jie

    2016-05-01

    To develop adriamycin (ADM)-encapsulated poly(lactic-co-glycolic acid) (PLGA) nanoparticles in a porous nano-hydroxyapatite/collagen scaffold (ADM-PLGA-NHAC). To provide novel strategies for future treatment of osteosarcoma, the properties of the scaffold, including its in vitro extended-release properties, the inhibition effects of ADM-PLGA-NHAC on the osteosarcoma MG63 cells, and its bone repair capacity, were investigated in vivo and in vitro. The PLGA copolymer was utilized as a drug carrier to deliver ADM-PLGA nanoparticles (ADM-PLGA-NP). Porous nano-hydroxyapatite and collagen were used to materials to produce the porous nano-hydroxyapatite/collagen scaffold (NHAC), into which the ADM-PLGA-NP was loaded. The performance of the drug-carrying scaffold was assessed using multiple techniques, including scanning electron microscopy and in vitro extended release. The antineoplastic activities of scaffold extracts on the human osteosarcoma MG63 cell line were evaluated in vitro using the cell counting kit-8 (CCK8) method and live-dead cell staining. The bone repair ability of the scaffold was assessed based on the establishment of a femoral condyle defect model in rabbits. ADM-PLGA-NHAC and NHAC were implanted into the rat muscle bag for immune response experiments. A tumor-bearing nude mice model was created, and the TUNEL and HE staining results were observed under optical microscopy to evaluate the antineoplastic activity and toxic side effects of the scaffold. The composite scaffold demonstrated extraordinary extended-release properties, and its extracts also exhibited significant inhibition of the growth of osteosarcoma MG63 cells. In the bone repair experiment, no significant difference was observed between ADM-PLGA-NHAC and NHAC by itself. In the immune response experiments, ADM-PLGA-NHAC exhibited remarkable biocompatibility. The in vivo antitumor experiment revealed that the implantation of ADM-PLGA-NHAC in the tumor resulted in a improved antineoplastic

  11. Building Service Delivery Networks: Partnership Evolution Among Children’s Behavioral Health Agencies in Response to New Funding

    PubMed Central

    Bunger, Alicia C.; Doogan, Nathan J.; Cao, Yiwen

    2014-01-01

    Meeting the complex needs of youth with behavioral health problems requires a coordinated network of community-based agencies. Although fiscal scarcity or retrenchment can limit coordinated services, munificence can stimulate service delivery partnerships as agencies expand programs, hire staff, and spend more time coordinating services. This study examines the 2-year evolution of referral and staff expertise sharing networks in response to substantial new funding for services within a regional network of children’s mental health organizations. Quantitative network survey data were collected from directors of 22 nonprofit organizations that receive funding from a county government-based behavioral health service fund. Both referral and staff expertise sharing networks changed over time, but results of a stochastic actor-oriented model of network dynamics suggest the nature of this change varies for these networks. Agencies with higher numbers of referral and staff expertise sharing partners tend to maintain these ties and/or develop new relationships over the 2 years. Agencies tend to refer to agencies they trust, but trust was not associated with staff expertise sharing ties. However, agencies maintain or form staff expertise sharing ties with referral partners, or with organizations that provide similar services. In addition, agencies tend to reciprocate staff expertise sharing, but not referrals. Findings suggest that during periods of resource munificence and service expansion, behavioral health organizations build service delivery partnerships in complex ways that build upon prior collaborative history and coordinate services among similar types of providers. Referral partnerships can pave the way for future information sharing relationships. PMID:25574359

  12. The city of San Diego Environmental Service Department`s Ridgehaven green building demonstration project: Project case study. Final report

    SciTech Connect

    Gottfried, D.A.; Schoichet, E.A.

    1998-05-01

    This case study describes the greening of Ridgehaven, the City of San Diego Environmental Services Department`s (ESD`s) new 73,000 sf{sup 2} headquarters building. The use of green design techniques within the conventional renovation of the existing structure significantly increased energy efficiency and indoor air quality (IAQ), and decreased the project`s environmental impact. Despite the constraining municipal budget, tight time schedule, and mandated public bidding procedures, the design team made energy efficiency, IAQ, and resource efficiency their primary design determinants. In the design phase the team screened materials and systems for environmental impact, and their effect on IAQ. Existing materials and systems were frequently reused, thus salvaging or recycling many items that might have gone to landfill. The design team also addressed the environmental impacts of construction and building operations. The ``Green Building Demonstration Program`` included educational outreach and the creation of a unique Manufacturer`s Partnership Program to highlight the effectiveness of green building products and systems. The evaluation featured computerized energy modeling and life-cycle based financial analysis to optimize the energy system design. The annual average energy consumption is designed to be close to 50% of the energy consumption for a comparable California Title 24 energy code compliant building, thus making it one of the most energy efficient buildings in San Diego.

  13. Building Climate Service Capacities in Eastern Africa with CHIRP and GeoCLIM

    NASA Astrophysics Data System (ADS)

    Pedreros, D. H.; Magadzire, T.; Funk, C. C.; Verdin, J. P.; Peterson, P.; Landsfeld, M.; Husak, G. J.

    2013-12-01

    In developing countries there is a great need for capacity building within national and regional climate agencies to develop and analyze historical and real time gridded rainfall datasets. These datasets are of key importance for monitoring climate and agricultural food production at decadal and seasonal time scales, and for informing local decision makers. The Famine Early Warning Systems Network (FEWS NET), working together with the U.S. Geological Survey (USGS) and the Climate Hazards Group (CHG) of the University of California Santa Barbara, has developed an integrated set of data products and tools to support the development of African climate services. The core data product is the Climate Hazards Group Infrared Precipitation (CHIRP) dataset. The CHIRP is a new rainfall dataset resulting from the blending of satellite estimated precipitation with high resolution precipitation climatology. The CHIRP depicts rainfall on five day totals at 5km spatial resolution from 1981 to present. The CHG is developing and deploying a standalone tool - the GeoCLIM - which will allow national and regional meteorological agencies to blend the CHIRP with station observations, run simple crop water balance models, and conduct climatological, trend, and time series analysis. Blending satellite estimates and gauge data helps overcome limited in situ observing networks. Furthermore, the GeoCLIM combines rainfall, soil, and evapotranspiration data with crop hydrological requirements to calculate agricultural water balance, presented as the Water Requirement Satisfaction Index (WRSI). The WRSI is a measurement of the degree in which a crop's hydrological requirements have been satisfied by rainfall. We present the results of a training session for personnel of the East African Intergovernmental Authority on Development Climate Prediction and Applications Center. The two week training program included the use of the GeoCLIM to improve CHIRP using station data, and to calculate and

  14. Constraint propagation of C{sup 2}-adjusted formulation: Another recipe for robust ADM evolution system

    SciTech Connect

    Tsuchiya, Takuya; Yoneda, Gen; Shinkai, Hisa-aki

    2011-03-15

    With a purpose of constructing a robust evolution system against numerical instability for integrating the Einstein equations, we propose a new formulation by adjusting the ADM evolution equations with constraints. We apply an adjusting method proposed by Fiske (2004) which uses the norm of the constraints, C{sup 2}. One of the advantages of this method is that the effective signature of adjusted terms (Lagrange multipliers) for constraint-damping evolution is predetermined. We demonstrate this fact by showing the eigenvalues of constraint propagation equations. We also perform numerical tests of this adjusted evolution system using polarized Gowdy-wave propagation, which show robust evolutions against the violation of the constraints than that of the standard ADM formulation.

  15. Reorienting health services with capacity building: a case study of the Core Skills in Health Promotion Project.

    PubMed

    Yeatman, H R; Nove, T

    2002-12-01

    This paper presents a case study of the application of a framework for capacity building [Hawe, P., King, L., Noort, M., Jordens, C. and Lloyd, B. (2000) Indicators to Help with Capacity Building in Health Promotion. NSW Health, Sydney] to describe actions aimed at building organizational support for health promotion within an area health service in New South Wales, Australia. The Core Skills in Health Promotion Project (CSHPP) arose from an investigation which reported that participants of a health promotion training course had increased health promotion skills but that they lacked the support to apply their skills in the workplace. The project was action-research based. It investigated and facilitated the implementation of a range of initiatives to support community health staff to apply a more preventive approach in their practice and it contributed to the establishment of new organizational structures for health promotion. An evaluation was undertaken 4 years after the CSHPP was established, and 2 years after it had submitted its final report. Interviews with senior managers, document analysis of written reports, and focus groups with middle managers and service delivery staff were undertaken. Change was achieved in the three dimensions of health infrastructure, program maintenance and problem solving capacity of the organization. It was identified that the critically important elements in achieving the aims of the project-partnership, leadership and commitment-were also key elements of the capacity building framework. This case study provides a practical example of the usefulness of the capacity building framework in orienting health services to be supportive of health promotion. PMID:12406922

  16. A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process

    PubMed Central

    An, Fan; Qu, Yueyang; Luo, Yong; Fang, Ning; Liu, Yang; Gao, Zhigang; Zhao, Weijie; Lin, Bingcheng

    2016-01-01

    New techniques are urgently needed to replace conventional long and costly pre-clinical testing in the new drug administration process. In this study, a laminated microfluidic device was fabricated to mimic the drug ADME response test in vivo. This proposed device was loaded and cultured with functional cells for drug response investigation and organ tissues that are involved in ADME testing. The drug was introduced from the top of the device and first absorbed by the Caco-2 cell layer, and then metabolized by the primary hepatocyte layer. It subsequently interacted with the MCF-7 cell layer, distributed in the lung, heart and fat tissues, and was finally eliminated through the dialysis membrane. Throughout this on-chip ADME process, the proposed device can be used as a reliable tool to simultaneously evaluate the drug anti-tumor activity, hepatotoxicity and pharmacokinetics. Furthermore, this device was proven to be able to reflect the hepatic metabolism of a drug, drug distribution in the target tissues, and the administration method of a drug. Furthermore, this microdevice is expected to reduce the number of drug candidates and accelerate the pre-clinical testing process subject to animal testing upon adaptation in new drug discovery. PMID:27122192

  17. Industrial applications of the IWA anaerobic digestion model No. 1 (ADM1).

    PubMed

    Batstone, D J; Keller, J

    2003-01-01

    In this paper, the IWA anaerobic digestion model No. 1 (ADM1) is applied to two case studies from contract work on industrial treatment plants. The first was the assessment of acid addition for pH decrease and avoidance of calcium carbonate (CaCO3) precipitation in a paper mill fed UASB. The simulation work found, with a high degree of confidence, that acid dosing was neither economical for pH control, nor had any real effect on the CaCO3 levels present in the reactor. A specific calcium carbonate precipitation equation was added to the ADM1 to undertake this study. The second case study was an assessment of the benefits of thermophilic (as opposed to mesophilic operation) for reduced ammonia inhibition, improved stability and gas production in a solids digester at a gelatine production facility. Here, it was predicted that thermophilic operation could not attain either goal to a satisfactory extent. In addition to demonstrating the application of the ADM1 to the two systems, we have also assessed the predictions generated in the case studies in terms of quality and utility. PMID:12926689

  18. The use of machine learning and nonlinear statistical tools for ADME prediction.

    PubMed

    Sakiyama, Yojiro

    2009-02-01

    Absorption, distribution, metabolism and excretion (ADME)-related failure of drug candidates is a major issue for the pharmaceutical industry today. Prediction of ADME by in silico tools has now become an inevitable paradigm to reduce cost and enhance efficiency in pharmaceutical research. Recently, machine learning as well as nonlinear statistical tools has been widely applied to predict routine ADME end points. To achieve accurate and reliable predictions, it would be a prerequisite to understand the concepts, mechanisms and limitations of these tools. Here, we have devised a small synthetic nonlinear data set to help understand the mechanism of machine learning by 2D-visualisation. We applied six new machine learning methods to four different data sets. The methods include Naive Bayes classifier, classification and regression tree, random forest, Gaussian process, support vector machine and k nearest neighbour. The results demonstrated that ensemble learning and kernel machine displayed greater accuracy of prediction than classical methods irrespective of the data set size. The importance of interaction with the engineering field is also addressed. The results described here provide insights into the mechanism of machine learning, which will enable appropriate usage in the future. PMID:19239395

  19. Application of ADM1 for modeling of biogas production from anaerobic digestion of Hydrilla verticillata.

    PubMed

    Chen, Xiaojuan; Chen, Zhihua; Wang, Xun; Huo, Chan; Hu, Zhiquan; Xiao, Bo; Hu, Mian

    2016-07-01

    The present study focused on the application of anaerobic digestion model no. 1 (ADM1) to simulate biogas production from Hydrilla verticillata. Model simulation was carried out by implementing ADM1 in AQUASIM 2.0 software. Sensitivity analysis was used to select the most sensitive parameters for estimation using the absolute-relative sensitivity function. Among all the kinetic parameters, disintegration constant (kdis), hydrolysis constant of protein (khyd_pr), Monod maximum specific substrate uptake rate (km_aa, km_ac, km_h2) and half-saturation constants (Ks_aa, Ks_ac) affect biogas production significantly, which were optimized by fitting of the model equations to the data obtained from batch experiments. The ADM1 model after parameter estimation was able to well predict the experimental results of daily biogas production and biogas composition. The simulation results of evolution of organic acids, bacteria concentrations and inhibition effects also helped to get insight into the reaction mechanisms. PMID:27010339

  20. A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process.

    PubMed

    An, Fan; Qu, Yueyang; Luo, Yong; Fang, Ning; Liu, Yang; Gao, Zhigang; Zhao, Weijie; Lin, Bingcheng

    2016-01-01

    New techniques are urgently needed to replace conventional long and costly pre-clinical testing in the new drug administration process. In this study, a laminated microfluidic device was fabricated to mimic the drug ADME response test in vivo. This proposed device was loaded and cultured with functional cells for drug response investigation and organ tissues that are involved in ADME testing. The drug was introduced from the top of the device and first absorbed by the Caco-2 cell layer, and then metabolized by the primary hepatocyte layer. It subsequently interacted with the MCF-7 cell layer, distributed in the lung, heart and fat tissues, and was finally eliminated through the dialysis membrane. Throughout this on-chip ADME process, the proposed device can be used as a reliable tool to simultaneously evaluate the drug anti-tumor activity, hepatotoxicity and pharmacokinetics. Furthermore, this device was proven to be able to reflect the hepatic metabolism of a drug, drug distribution in the target tissues, and the administration method of a drug. Furthermore, this microdevice is expected to reduce the number of drug candidates and accelerate the pre-clinical testing process subject to animal testing upon adaptation in new drug discovery. PMID:27122192

  1. A decade of building massage therapy services at an academic medical center as part of a healing enhancement program.

    PubMed

    Rodgers, Nancy J; Cutshall, Susanne M; Dion, Liza J; Dreyer, Nikol E; Hauschulz, Jennifer L; Ristau, Crystal R; Thomley, Barb S; Bauer, Brent A

    2015-02-01

    The use of complementary and integrative medicine therapies is steadily becoming an integral part of health care. Massage therapy is increasingly offered to hospitalized patients for various conditions to assist with the management of common symptoms such as pain, anxiety, and tension. This article summarizes a decade of building the massage therapy service at a large tertiary care medical center, from the early pilot studies and research to the current program offerings, and the hopes and dreams for the future. PMID:25547538

  2. Building an Agricultural Extension Services System Supported by ICTs in Tanzania: Progress Made, Challenges Remain

    ERIC Educational Resources Information Center

    Sanga, C.; Kalungwizi, V. J.; Msuya, C. P.

    2013-01-01

    The conventional agricultural extension service in Tanzania is mainly provided by extension officers visiting farmers to provide agricultural advisory service. This system of extension service provision faces a number of challenges including the few number of extension officers and limited resources. This article assesses the effectiveness of an…

  3. The Global Health Strategy of the Department of Health and Human Services: building on the lessons of PEPFAR.

    PubMed

    Daulaire, Nils

    2012-07-01

    Building on its experience as a principal participant in the President's Emergency Plan for AIDS Relief, the Department of Health and Human Services has embarked on a new era of global initiatives that ultimately will protect the health of Americans. The Global Health Strategy announced by health and human services secretary Kathleen Sebelius in January 2012 recognizes that the health of Americans is intertwined with that of the rest of the world. The initiative features ten objectives that range from enhanced global health surveillance and preventing infectious diseases and health threats to health diplomacy. The Global Health Strategy is designed to make optimal use of the department's many specialty agencies and their considerable technical and programmatic expertise. The strategy moves beyond the President's Emergency Plan for AIDS Relief to redefine Health and Human Services' role outside US borders in addressing the health challenges of the twenty-first century. PMID:22778347

  4. Analysis of energy use in building services of the industrial sector in California: A literature review and a preliminary characterization

    SciTech Connect

    Akbari, H.; Borgers, T.; Gadgil, A.; Sezgen, O.

    1991-04-01

    Energy use patterns in many of California's fastest-growing industries are not typical of those in the mix of industries elsewhere in the US. Many California firms operate small and medium-sized facilities, often in buildings used simultaneously or interchangeably for commercial (office, retail, warehouse) and industrial activities. In these industrial subsectors, the energy required for building services'' to provide occupant comfort and necessities (lighting, HVAC, office equipment, computers, etc.) may be at least as important as the more familiar process energy requirements -- especially for electricity and on-peak demand. In this report, published or unpublished information on energy use for building services in the industrial sector have been compiled and analyzed. Seven different sources of information and data relevant to California have been identified. Most of these are studies and/or projects sponsored by the Department of Energy, the California Energy Commission, and local utilities. The objectives of these studies were diverse: most focused on industrial energy use in general, and, in one case, the objective was to analyze energy use in commercial buildings. Only one of these studies focused directly on non-process energy use in industrial buildings. Our analysis of Northern California data for five selected industries shows that the contribution of total electricity consumption for lighting ranges from 9.5% in frozen fruits to 29.1% in instruments; for air-conditioning, it ranges from nonexistent in frozen fruits to 35% in instrument manufacturing. None of the five industries selected had significant electrical space heating. Gas space heating ranges from 5% in motor vehicles facilities to more than 58% in the instrument manufacturing industry. 15 refs., 15 figs., 9 tabs.

  5. Building web service interfaces to geoscience data sets: EarthCube GeoWS project activities at the IRIS DMC

    NASA Astrophysics Data System (ADS)

    Trabant, C. M.; Ahern, T. K.; Stults, M.

    2015-12-01

    At the IRIS Data Management Center (DMC) we have been developing web service data access interfaces for our, primarily seismological, repositories for five years. These interfaces have become the primary access mechanisms for all data extraction from the DMC. For the last two years the DMC has been a principal participant in the GeoWS project, which aims to develop common web service interfaces for data access across hydrology, geodesy, seismology, marine geophysics, atmospheric and other geoscience disciplines. By extending our approach we have converged, along with other project members, on a web service interface and presentation design appropriate for geoscience and other data. The key principles of the approach include using a simple subset of RESTful concepts, common calling conventions whenever possible, a common tabular text data set convention, human-readable documentation and tools to help scientific end users learn how to use the interfaces. The common tabular text format, called GeoCSV, has been incorporated into the DMC's seismic station and event (earthquake) services. In addition to modifying our existing services, we have developed prototype GeoCSV web services for data sets managed by external (unfunded) collaborators. These prototype services include interfaces for data sets at NGDC/NCEI (water level tides and meteorological satellite measurements), INTERMAGNET repository and UTEP gravity and magnetic measurements. In progress are interfaces for WOVOdat (volcano observatory measurements), NEON (ecological observatory measurements) and more. An important goal of our work is to build interfaces usable by non-technologist end users. We find direct usability by researchers to be a major factor in cross-discipline data use, which itself is a key to solving complex research questions. In addition to data discovery and collection by end users, these interfaces provide a foundation upon which federated data access and brokering systems are already being

  6. East side. Building 517 is to the right. Building 511 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    East side. Building 517 is to the right. Building 511 is to the left. - Fitzsimons General Hospital, Central Service Building, North of Building No. 511, East of corridor connecting Building 511 to Building 515, Aurora, Adams County, CO

  7. Building a Web-Based Laboratory so Users Can Experiment with New Services

    ERIC Educational Resources Information Center

    Battles, Jason J.; Combs, Joseph

    2008-01-01

    Librarians expend considerable resources to develop services and implement new products catering their users' changing needs. Such efforts begs for the involvement of library users in the development and/or beta process. The authors, both academic librarians, realized that much of their online services were underused, so they devised a plan to…

  8. A Service-Learning Exercise in Building Civil Engagement in Teacher Education

    ERIC Educational Resources Information Center

    Moguel, David L.

    2003-01-01

    Service learning can be a vehicle to promote democracy in the teacher education classroom. Incorporating service learning into a teacher education program is an uphill battle: teacher candidates lead complicated lives with professional and family responsibilities, some continue long-standing volunteer commitments to their communities, and course…

  9. Collaborative Inquiry: Building Pre-Service Teachers' Capacity for ICT Pedagogical Integration

    ERIC Educational Resources Information Center

    Henderson, Michael; Cerovac, Milorad; Bellis, Natalie; Lancaster, Greg

    2013-01-01

    As part of the Teaching Teachers for the Future (TTF) project, Monash University initiated several strategies to assist pre-service teachers' integration of ICTs in their classroom practice. These included modelling of ICT pedagogical integration, assessment of ICT pedagogical integration, relocating pre-service teacher classes to a working…

  10. To Build a Civilization of Love: Catholic Education and Service Learning.

    ERIC Educational Resources Information Center

    Reidy, Pamela J.

    This book considers service learning an integral aspect of Catholic education. The first four chapters of the book offer theoretical considerations regarding the essential elements of Catholic service learning: the theology of ministry; notable adolescent milestones; Catholic social teaching; and curriculum development. The final chapters are more…

  11. Research on K-12 School-Based Service-Learning: The Evidence Builds.

    ERIC Educational Resources Information Center

    Bilig, Shelley H.

    2000-01-01

    Discusses the prevalence of service learning, growing public support, definitions, quality standards, and salutary research evidence. Service learning positively influences students' personal and interpersonal development, lifestyle choices, appreciation for cultural diversity, sense of civic and social responsibility, motivation, attendance,…

  12. Personalized Research Consultation Service for Graduate Students: Building a Program Based on Research Findings.

    ERIC Educational Resources Information Center

    Gratch, Bonnie G.; York, Charlene C.

    1991-01-01

    Describes the development of a Personalized Research Consultation Service (PERCS) for graduate students at Bowling Green State University. Graduate students' library research behavior and adult learning strategies are discussed; an evaluation of the program is reviewed; and the impact on library services, including computer searches and…

  13. Building Partnerships for Service-Learning. The Jossey-Bass Higher and Adult Education Series.

    ERIC Educational Resources Information Center

    Jacoby, Barbara

    The chapters in this collection contain information, exemplary models, and practical tools to make service-learning succeed. The chapters are: (1) "Fundamentals of Service-Learning Partnerships" (Barbara Jacoby); (2) "Developing a Theory and Practice of Campus-Community Partnerships" (Sandra Enos and Keith Morton); (3) "Assessment as a Means of…

  14. Service Learning: High School Social Studies Students "Building Bridges" to the Community

    ERIC Educational Resources Information Center

    Cranford, Sara L.

    2011-01-01

    This case study examined the relationships between the programmatic features of service learning and student willingness to participate in and development during a service learning opportunity in the secondary, Social Studies classroom. The sample included two sections of Advanced Placement Psychology which consisted of 58 junior and senior…

  15. Building the Capacity of Indonesian Education Universities for ICT in Pre-Service Teacher Education: A Case Study of a Strategic Planning Exercise

    ERIC Educational Resources Information Center

    Lim, Cher Ping; Pannen, Paulina

    2012-01-01

    This paper documents how four Indonesian teacher education institutions (TEIs) engaged in strategic planning to build their capacity in developing pre-service teachers' ICT in education competencies. These TEIs adopted a holistic approach towards strategic planning by drawing upon the six dimensions of the "Capacity Building Toolkit" for TEIs in…

  16. An ASM/ADM model interface for dynamic plant-wide simulation.

    PubMed

    Nopens, Ingmar; Batstone, Damien J; Copp, John B; Jeppsson, Ulf; Volcke, Eveline; Alex, Jens; Vanrolleghem, Peter A

    2009-04-01

    Mathematical modelling has proven to be very useful in process design, operation and optimisation. A recent trend in WWTP modelling is to include the different subunits in so-called plant-wide models rather than focusing on parts of the entire process. One example of a typical plant-wide model is the coupling of an upstream activated sludge plant (including primary settler, and secondary clarifier) to an anaerobic digester for sludge digestion. One of the key challenges when coupling these processes has been the definition of an interface between the well accepted activated sludge model (ASM1) and anaerobic digestion model (ADM1). Current characterisation and interface models have key limitations, the most critical of which is the over-use of X(c) (or lumped complex) variable as a main input to the ADM1. Over-use of X(c) does not allow for variation of degradability, carbon oxidation state or nitrogen content. In addition, achieving a target influent pH through the proper definition of the ionic system can be difficult. In this paper, we define an interface and characterisation model that maps degradable components directly to carbohydrates, proteins and lipids (and their soluble analogues), as well as organic acids, rather than using X(c). While this interface has been designed for use with the Benchmark Simulation Model No. 2 (BSM2), it is widely applicable to ADM1 input characterisation in general. We have demonstrated the model both hypothetically (BSM2), and practically on a full-scale anaerobic digester treating sewage sludge. PMID:19232670

  17. Mitigative action of mono isoamyl 2, 3-dimercaptosuccinate (MiADMS) against cadmium-induced damage in cultured rat normal liver cells

    PubMed Central

    Odewumi, Caroline O.; Buggs, Rebecca; Badisa, Veera L.D.; Latinwo, Lekan M.; Badisa, Ramesh B.; Ikediobi, Christopher O.; Darling-Reed, Selina F.; Owens, Marcia A.

    2012-01-01

    Cadmium is non-essential, carcinogenic and multitarget pollutant in the environment. Monoisoamyl 2, 3-dimercaptosuccinate (MiADMS) is an ester of dimercaptosuccinicacid that acts as an antioxidant and chelator. Therefore, the mitigative action of MiADMS on viability, morphology, antioxidative enzymes and cell cycle were studied on rat liver cells treated with cadmium chloride (CdCl2). The cells were treated with 150 μM CdCl2 alone or cotreated with 300 μM MiADMS (concurrently, 2 h or 4 h post CdCl2 treatment) for 24 h. The viability of cells treated with CdCl2 alone was decreased in comparison to the control cells. Cotreatment with MiADMS resulted in an increase in cell viability in comparison to the CdCl2 alone treated cells. The CdCl2 treatment altered the morphological shape of the cells, while cotreatment with MiADMS restored the shape. Antioxidative enzymes activities were decreased in the cells treated with CdCl2 alone, while MiADMS cotreatment resulted in an increase in enzyme activities. The CdCl2 arrested the cells in S phase of the cell cycle. Cotreatment with MiADMS alleviated cell cycle arrest by shifting to G1 phase. These results clearly show the mitigative action of MiADMS on CdCl2 toxicity and may suggest that MiADMS can be used as an antidote against cadmium. PMID:21911053

  18. Use of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Bioaccumulation Assessments for Fish

    SciTech Connect

    Nichols, John W.; Erhardt, Susan; Dyer, Scott; James, Margaret O.; Moore, Margo; Plotzke, Kathleen; Segner, Helmut; Schultz, Irvin R.; Thomas, Karluss; Vasiluk, Luba; Weisbrod, Anne V.

    2007-11-01

    A scientific workshop was held in 2006 to discuss the use of in vitro Absorption, Distribution, Metabolism, and Excretion (ADME) data in chemical bioaccumulation assessments for fish. Computer-based (in silico) modeling tools are widely used to estimate chemical bioaccumulation. These in silico methods have inherent limitations that result in inaccurate estimates for many compounds. Based on a review of the science workshop participants concluded that two factors, absorption and metabolism, represent the greatest sources of uncertainty in current bioaccumulation models. Both factors can be investigated experimentally using in vitro test systems.

  19. Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives.

    PubMed

    Kraljević, Tatjana Gazivoda; Klika, Mateja; Kralj, Marijeta; Martin-Kleiner, Irena; Jurmanović, Stella; Milić, Astrid; Padovan, Jasna; Raić-Malić, Silvana

    2012-01-01

    The synthesis of the novel 5-alkyl pyrimidine derivatives, 5,6-dihydrofuro[2,3-d]pyrimidines and 5-alkyl N-methoxymethyl pyrimidine derivatives and evaluation of their cytostatic activities are described. The mechanism of antiproliferative effect of 5-(2-chloroethyl)-substituted pyrimidine 3 that exerted the pronounced cytostatic activity was studied in further details on colon carcinoma (HCT116) cells. The cell cycle perturbation analysis demonstrated severe DNA damage (G2/M arrest) pointing to a potential DNA alkylating ability of 3. Preliminary ADME data of 3 and its 6-methylated structural congener (6-Me-3) showed their high permeability and good metabolic stability. PMID:22130132

  20. Constructing CoRes--A Strategy for Building PCK in Pre-Service Science Teacher Education

    ERIC Educational Resources Information Center

    Hume, Anne; Berry, Amanda

    2011-01-01

    This paper presents findings from an exploratory study into a science teacher education initiative that seeks to build the foundations on which novice teachers can begin developing their pedagogical content knowledge (PCK). The initiative involved the use of Content Representations (CoRes), which were originally developed as part of a strategy for…

  1. Reflections on Building Capacity as a Supervisor in College Student Services

    ERIC Educational Resources Information Center

    McGraw, Cathlene E.

    2011-01-01

    Supervision, as this author discovered, is about building relationships with groups and individuals, as well as implementing policies and practices to create clear expectations. These policies, practices, expectations, and relationships should give rise to a work environment that encourages creativity, learning, and personal growth. In this…

  2. 48 CFR 652.236-71 - Foreign Service Buildings Act, as Amended.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... competition under this solicitation to: (1) American-owned firms, as described in paragraph (b) of this... American firms for comparable diplomatic and consular building projects. (b) To qualify as an American... three (3) years and employment of U.S. citizens or permanent residents in more than half of the...

  3. Do Sports Build or Reveal Character?--An Exploratory Study at One Service Academy

    ERIC Educational Resources Information Center

    Doty, Joseph P.; Lumpkin, Angela

    2010-01-01

    Whether participating in sports builds character and if character can be measured continues to be a debated, though important, topic. Almost daily we read or hear about athletes displaying poor character. Most research shows that as the level of sport competition increases, the level of character decreases. However, participating in sports, at any…

  4. New Opportunities for a Professional Services Firm: Building a Brand and Developing a Marketing Strategy

    ERIC Educational Resources Information Center

    Smith, Rachel K.

    2013-01-01

    BD Capital Management, an investment advisory firm based in Tulsa, Oklahoma, is dedicated to providing personal, comprehensive investment services to individuals and families, pension and profit sharing plans, endowment funds, trusts, estates, and charitable organizations.

  5. Functional Service Domain Architecture Management: Building the Foundation for Situational Method Engineering

    NASA Astrophysics Data System (ADS)

    Stock, Daniel; Winter, Robert; Mayer, Jörg H.

    Functional service domains are logical design artifacts that are intended to achieve better business/IT alignment. Their widespread utilization clearly indicates their perceived usefulness in managing the complexity of aligning business structures with IT structures. However, a common understanding of functional service domains and the associated principles that govern their design and evolution is still missing. So far, the literature provides only little guidance in closing this gap. This article contributes to the foundations that allow for the design of a situational method for functional service domain architecture management. Reviewing current literature, a framework is pro posed that supports the identification of functional service domain architecture management patterns. Based on a better understanding of functional domain architecture management approaches, situational method engineering for functional domains can be applied by identifying context types and goal vectors, designing fragments, and associating successfully adopted method fragments with specific situations. The validity of the proposed framework is tested by five case studies.

  6. Semantic-based web service discovery and chaining for building an Arctic spatial data infrastructure

    NASA Astrophysics Data System (ADS)

    Li, W.; Yang, C.; Nebert, D.; Raskin, R.; Houser, P.; Wu, H.; Li, Z.

    2011-11-01

    Increasing interests in a global environment and climate change have led to studies focused on the changes in the multinational Arctic region. To facilitate Arctic research, a spatial data infrastructure (SDI), where Arctic data, information, and services are shared and integrated in a seamless manner, particularly in light of today's climate change scenarios, is urgently needed. In this paper, we utilize the knowledge-based approach and the spatial web portal technology to prototype an Arctic SDI (ASDI) by proposing (1) a hybrid approach for efficient service discovery from distributed web catalogs and the dynamic Internet; (2) a domain knowledge base to model the latent semantic relationships among scientific data and services; and (3) an intelligent logic reasoning mechanism for (semi-)automatic service selection and chaining. A study of the influence of solid water dynamics to the bio-habitat of the Arctic region is used as an example to demonstrate the prototype.

  7. South Dakota's Libraries--Building Toward 2002: A Statewide Plan for the Development of Library and Information Services, 1998-2002.

    ERIC Educational Resources Information Center

    South Dakota State Library, Pierre.

    This document presents the South Dakota statewide plan for library and information services for 1998-2002. The first section summarizes the use of technology to deliver library services from 1913 to the present. The second section addresses building toward stronger libraries in 2002, including themes from focus group discussions held in 1997,…

  8. Environmental zoning for service life prediction of building components in Malaysia

    NASA Astrophysics Data System (ADS)

    U, Fathoni; O, Rohayu C.; M, Zakaria C.

    2013-06-01

    Interactions between building materials and environment are very complex. More often than not, deterioration of building component is due to environmental loads with the result of reducing its durability. The environmental loads are less overlooked or underestimated in early design phase. Objective of this study is to distinguish the difference of environmental load for different area in Malaysia. The environmental data consist of climate and pollution data which extracted from the Malaysia Meteorology Department's data bank. From this study, six different environmental zones in Malaysia are distinguished. There are different characteristic of environmental parameters found where some of them dominant to others. This information can assist the engineer to justify the use of different technology, material or construction method in construction industry.

  9. Recent developments in software tools for high-throughput in vitro ADME support with high-resolution MS.

    PubMed

    Paiva, Anthony; Shou, Wilson Z

    2016-08-01

    The last several years have seen the rapid adoption of the high-resolution MS (HRMS) for bioanalytical support of high throughput in vitro ADME profiling. Many capable software tools have been developed and refined to process quantitative HRMS bioanalysis data for ADME samples with excellent performance. Additionally, new software applications specifically designed for quan/qual soft spot identification workflows using HRMS have greatly enhanced the quality and efficiency of the structure elucidation process for high throughput metabolite ID in early in vitro ADME profiling. Finally, novel approaches in data acquisition and compression, as well as tools for transferring, archiving and retrieving HRMS data, are being continuously refined to tackle the issue of large data file size typical for HRMS analyses. PMID:27487387

  10. Total Structure Determination of Au21(S-Adm)15 and Geometrical/Electronic Structure Evolution of Thiolated Gold Nanoclusters.

    PubMed

    Chen, Shuang; Xiong, Lin; Wang, Shuxin; Ma, Zhongyun; Jin, Shan; Sheng, Hongting; Pei, Yong; Zhu, Manzhou

    2016-08-31

    The larger size gold nanoparticles typically adopt a face-centered cubic (fcc) atomic packing, while in the ultrasmall nanoclusters the packing styles of Au atoms are diverse, including fcc, hexagonal close packing (hcp), and body-centered cubic (bcc), depending on the ligand protection. The possible conversion between these packing structures is largely unknown. Herein, we report the growth of a new Au21(S-Adm)15 nanocluster (S-Adm = adamantanethiolate) from Au18(SR)14 (SR = cyclohexylthiol), with the total structure determined by X-ray crystallography. It is discovered that the hcp Au9-core in Au18(SR)14 is transformed to a fcc Au10-core in Au21(S-Adm)15. Combining with density functional theory (DFT) calculations, we provide critical information about the growth mechanism (geometrical and electronic structure) and the origin of fcc-structure formation for the thiolate-protected gold nanoclusters. PMID:27552520

  11. Modified ADM1 for modelling an UASB reactor laboratory plant treating starch wastewater and synthetic substrate load tests.

    PubMed

    Hinken, L; Huber, M; Weichgrebe, D; Rosenwinkel, K-H

    2014-11-01

    A laboratory plant consisting of two UASB reactors was used for the treatment of industrial wastewater from the wheat starch industry. Several load tests were carried out with starch wastewater and the synthetic substrates glucose, acetate, cellulose, butyrate and propionate to observe the impact of changing loads on gas yield and effluent quality. The measurement data sets were used for calibration and validation of the Anaerobic Digestion Model No. 1 (ADM1). For a precise simulation of the detected glucose degradation during load tests with starch wastewater and glucose, it was necessary to incorporate the complete lactic acid fermentation into the ADM1, which contains the formation and degradation of lactate and a non-competitive inhibition function. The modelling results of both reactors based on the modified ADM1 confirm an accurate calculation of the produced gas and the effluent concentrations. Especially, the modelled lactate effluent concentrations for the load cases are similar to the measurements and justified by literature. PMID:25043796

  12. Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling.

    PubMed

    Pham-The, Hai; Casañola-Martin, Gerardo; Garrigues, Teresa; Bermejo, Marival; González-Álvarez, Isabel; Nguyen-Hai, Nam; Cabrera-Pérez, Miguel Ángel; Le-Thi-Thu, Huong

    2016-02-01

    In many absorption, distribution, metabolism, and excretion (ADME) modeling problems, imbalanced data could negatively affect classification performance of machine learning algorithms. Solutions for handling imbalanced dataset have been proposed, but their application for ADME modeling tasks is underexplored. In this paper, various strategies including cost-sensitive learning and resampling methods were studied to tackle the moderate imbalance problem of a large Caco-2 cell permeability database. Simple physicochemical molecular descriptors were utilized for data modeling. Support vector machine classifiers were constructed and compared using multiple comparison tests. Results showed that the models developed on the basis of resampling strategies displayed better performance than the cost-sensitive classification models, especially in the case of oversampling data where misclassification rates for minority class have values of 0.11 and 0.14 for training and test set, respectively. A consensus model with enhanced applicability domain was subsequently constructed and showed improved performance. This model was used to predict a set of randomly selected high-permeability reference drugs according to the biopharmaceutics classification system. Overall, this study provides a comparison of numerous rebalancing strategies and displays the effectiveness of oversampling methods to deal with imbalanced permeability data problems. PMID:26643659

  13. ESA's Spaceborne Lidar Mission ADM-Aeolus; Recent Achievements and Preparations for Launch

    NASA Astrophysics Data System (ADS)

    Grete Straume, Anne; Elfving, Anders; Wernham, Denny; Culoma, Alain; Mondin, Linda; de Bruin, Frank; Kanitz, Thomas; Schuettemeyer, Dirk; Buscaglione, Fabio; Dehn, Angelika

    2016-06-01

    Within ESA's Living Planet Programme, the Atmospheric Dynamics Mission (ADM-Aeolus) was chosen as the second Earth Explorer Core mission in 1999. It shall demonstrate the potential of high spectral resolution Doppler Wind lidars for operational measurements of wind profiles and their use in Numerical Weather Prediction (NWP). Spin-off products are profiles of cloud and aerosol optical properties. ADM-Aeolus carries the novel Doppler Wind lidar instrument ALADIN. Recently the two ALADIN laser transmitters were successfully qualified and delivered for further instrument integration. The instrument delivery will follow later this year and the satellite qualification and launch readiness is scheduled for 2016. In February 2015, an Aeolus Science and Calibration and Validation (CAL/VAL) Workshop was held in ESA-ESRIN, Frascati, Italy, bringing industry, the user community and ESA together to prepare for the Aeolus Commissioning and Operational Phases. During the Workshop the science, instrument and product status, commissioning phase planning and the extensive number of proposals submitted in response to the Aeolus CAL/VAL call in 2014 were presented and discussed. A special session was dedicated to the Aeolus CAL/VAL Implementation Plan. In this paper, the Aeolus mission, status and launch preparation activities are described.

  14. Building a Secure and Feature-rich Mobile Mapping Service App Using HTML5: Challenges and Best Practices

    SciTech Connect

    Karthik, Rajasekar; Patlolla, Dilip Reddy; Sorokine, Alexandre; White, Devin A; Myers, Aaron T

    2014-01-01

    Managing a wide variety of mobile devices across multiple mobile operating systems is a security challenge for any organization [1, 2]. With the wide adoption of mobile devices to access work-related apps, there is an increase in third-party apps that might either misuse or improperly handle user s personal or sensitive data [3]. HTML5 has been receiving wide attention for developing cross-platform mobile apps. According to International Data Corporation (IDC), by 2015, 80% of all mobile apps will be based in part or wholly upon HTML5 [4]. Though HTML5 provides a rich set of features for building an app, it is a challenge for organizations to deploy and manage HTML5 apps on wide variety of devices while keeping security policies intact. In this paper, we will describe an upcoming secure mobile environment for HTML5 apps, called Sencha Space that addresses these issues and discuss how it will be used to design and build a secure and cross-platform mobile mapping service app. We will also describe how HTML5 and a new set of related technologies such as Geolocation API, WebGL, Open Layers 3, and Local Storage, can be used to provide a high end and high performance experience for users of the mapping service app.

  15. Web Services as Building Blocks for an Open Coastal Observing System

    NASA Astrophysics Data System (ADS)

    Breitbach, G.; Krasemann, H.

    2012-04-01

    In coastal observing systems it is needed to integrate different observing methods like remote sensing, in-situ measurements, and models into a synoptic view of the state of the observed region. This integration can be based solely on web services combining data and metadata. Such an approach is pursued for COSYNA (Coastal Observing System for Northern and Artic seas). Data from satellite and radar remote sensing, measurements of buoys, stations and Ferryboxes are the observation part of COSYNA. These data are assimilated into models to create pre-operational forecasts. For discovering data an OGC Web Feature Service (WFS) is used by the COSYNA data portal. This Web Feature Service knows the necessary metadata not only for finding data, but in addition the URLs of web services to view and download the data. To make the data from different resources comparable a common vocabulary is needed. For COSYNA the standard names from CF-conventions are stored within the metadata whenever possible. For the metadata an INSPIRE and ISO19115 compatible data format is used. The WFS is fed from the metadata-system using database-views. Actual data are stored in two different formats, in NetCDF-files for gridded data and in an RDBMS for time-series-like data. The web service URLs are mostly standard based the standards are mainly OGC standards. Maps were created from netcdf files with the help of the ncWMS tool whereas a self-developed java servlet is used for maps of moving measurement platforms. In this case download of data is offered via OGC SOS. For NetCDF-files OPeNDAP is used for the data download. The OGC CSW is used for accessing extended metadata. The concept of data management in COSYNA will be presented which is independent of the special services used in COSYNA. This concept is parameter and data centric and might be useful for other observing systems.

  16. Building effective service linkages in primary mental health care: a narrative review part 2

    PubMed Central

    2011-01-01

    Background Primary care services have not generally been effective in meeting mental health care needs. There is evidence that collaboration between primary care and specialist mental health services can improve clinical and organisational outcomes. It is not clear however what factors enable or hinder effective collaboration. The objective of this study was to examine the factors that enable effective collaboration between specialist mental health services and primary mental health care. Methods A narrative and thematic review of English language papers published between 1998 and 2009. An expert reference group helped formulate strategies for policy makers. Studies of descriptive and qualitative design from Australia, New Zealand, UK, Europe, USA and Canada were included. Data were extracted on factors reported as enablers or barriers to development of service linkages. These were tabulated by theme at clinical and organisational levels and the inter-relationship between themes was explored. Results A thematic analysis of 30 papers found the most frequently cited group of factors was "partnership formation", specifically role clarity between health care workers. Other factor groups supporting clinical partnership formation were staff support, clinician attributes, clinic physical features and evaluation and feedback. At the organisational level a supportive institutional environment of leadership and change management was important. The expert reference group then proposed strategies for collaboration that would be seen as important, acceptable and feasible. Because of the variability of study types we did not exclude on quality and findings are weighted by the number of studies. Variability in local service contexts limits the generalisation of findings. Conclusion The findings provide a framework for health planners to develop effective service linkages in primary mental health care. Our expert reference group proposed five areas of strategy for policy makers

  17. The Building of Digital Archives Personalized Service Website based on Web 2.0

    NASA Astrophysics Data System (ADS)

    Ziyu, Cheng; Haining, An

    Web2.0 technology has been applied in the digital archive personalized service website. Although there are few users and they lack of understanding currently, the author believe that web2.0 relying on many advantages of fast, convenient, and the zero cost, will be approved by more and more users in the future. With the continuous perfection and popularity of web2.0, the personalized service of digital archives will display a new vitality. In the paper, author proposes the application approaches of web2.0 in the system.

  18. Building Rural Surgical Networks: An Evidence-Based Approach to Service Delivery and Evaluation.

    PubMed

    Kornelsen, Jude; Friesen, Randy

    2016-08-01

    Formalized rural health service delivery networks are emerging as an over-arching response to the attrition of rural surgical and maternity services in Canada. In effective networks, there is strong collaborative leadership, form follows function, core network elements are identified and site-specific variations are accommodated to meet the surgical needs of the population in each geographic catchment. The network catchment must reflect the natural alliances that already exist among health professionals, policy makers, health administrators, academic institutions and communities. Although each key stakeholder plays a key role in determining success, value is added through the synergistic interplay of all participants. PMID:27585024

  19. Building an Evidence Base for Speech-Language Services in the Schools: Challenges and Recommendations

    ERIC Educational Resources Information Center

    Whitmire, Kathleen A.; Rivers, Kenyatta O.; Mele-McCarthy, Joan A.; Staskowski, Maureen

    2014-01-01

    Speech-language pathologists are faced with demands for evidence to support practice. Federal legislation requires high-quality evidence for decisions regarding school-based services as part of evidence-based practice. The purpose of this article is to discuss the limited scientific evidence for making appropriate decisions about speech-language…

  20. BUILDING A U.S. NATIONAL ATLAS OF ECOLOGICAL GOODS AND SERVICES

    EPA Science Inventory

    The Millenium Ecosystem Assessment (2005) has popularized and begun to formalize the long-standing concept of ecological goods and services (e.g., Westman 1977). The US Environmental Protection Agency (USEPA) is re-organizing its Ecological Research Program around the concept of...

  1. Building Healthier Children through Family-Style Service in School Cafeterias

    ERIC Educational Resources Information Center

    Coborn, Jamie E.; Marquart, Len; Burgess-Champoux, Teri L.; Rosen, Renee A.

    2015-01-01

    Schools are recognized as ideal environments to promote and enhance the health of children. Previous research has shown a positive association exists between increased prevalence of family-style meals and children's health. Use of family-style service provides opportunities to improve children's overall health and well-being through increased…

  2. Data Services in Western Europe: Reflections on Variations in the Conditions of Academic Institution-Building

    ERIC Educational Resources Information Center

    Rokkan, Stein

    1976-01-01

    Examines the expansion of data services in Western Europe after the computer revolution. Stresses that distinctive career lines and eventually a distinctive profession must be created to cope with the proliferation of data and the increase in demand for access to this data. (Author/DB)

  3. Building Bridges Symposium. Linking the Disciplines During Pre-Service Teacher Education.

    ERIC Educational Resources Information Center

    Daugherty, Michael; Foehr, Regina; Haynes, Thomas; McBride, Lawrence

    This paper is further subtitled "Presentations of integrated units of instruction by interdisciplinary teams of pre-service teacher education students showcasing student-developed curriculum integration ideas." The units include the following: "Get Your Kicks on Route 66" (integrating Family and Consumer Sciences, Business, and Industrial…

  4. Cross-Cultural Service Learning with Native Americans: Pedagogy for Building Cultural Competence

    ERIC Educational Resources Information Center

    Bolea, Patricia S.

    2012-01-01

    This paper articulates a curricular approach that centers on a Native American service learning course. Social work students engaged in cross-cultural immersion on a reservation in the United States. By examination of historical United States policy impacting Indian tribes and contemporary experiences that challenge basic instruction in public…

  5. Service Learning: Providing the Building Blocks for a Socially Responsible Nursing Role

    ERIC Educational Resources Information Center

    Johnson, Judith M.

    2013-01-01

    An explanatory correlational study was conducted to explore whether and to what extent a relationship between hours of participation in service learning and commitment to social responsibility exists for students enrolled in pre-licensure baccalaureate-nursing programs currently participating in the Nursing Licensure Compact. The convenience…

  6. Service-Learning Program at University and It's Role in Building Child-Friendly Community

    ERIC Educational Resources Information Center

    Krumes Šimunovic, Irena

    2014-01-01

    This paper presents an action research associated with Faculty of Education in Osijek, dislocated study in Slavonski Brod with pre-service teachers during the four academic years. The study follows the process of improving student learning through collaboration colleges and local communities for the benefit of gifted children in lower grades of…

  7. 48 CFR 552.232-72 - Final Payment Under Building Services Contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contract has been assigned under Assignment of Claims Act of 1940, as amended (31 U.S. 3727, 41 U.S.C. 15... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Final Payment Under... SERVICES ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of...

  8. 48 CFR 552.232-72 - Final Payment Under Building Services Contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... contract has been assigned under Assignment of Claims Act of 1940, as amended (31 U.S. 3727, 41 U.S.C. 15... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Final Payment Under... SERVICES ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of...

  9. Community Nonprofit Organizations and Service-Learning: Resource Constraints to Building Partnerships with Universities

    ERIC Educational Resources Information Center

    Bushouse, Brenda K.

    2005-01-01

    Articles on service-learning champion its potential to create a win-win-win situation for the university, students, and community; however, substantial scholarly attention to pedagogical benefits for students and universities contrasts with limited research assessing community partner perspectives. This study presents findings on nonprofit…

  10. Building Student Self-Efficacy and Mastery of Skills through Service Learning Partnerships

    ERIC Educational Resources Information Center

    Hilarski, C.

    2013-01-01

    Undergraduate students (N = 40) responded positively to a semantic differential scale after experiencing a "direct practice" service learning group work course. Qualitative data documented student's perceptions of increased skill levels relating to self-efficacy--understood as positively influencing mastery of skills and performance…

  11. Building on Authentic Learning for Pre-Service Teachers in a Technology-Rich Environment

    ERIC Educational Resources Information Center

    Latham, Gloria; Carr, Nicky

    2015-01-01

    The article "Authentic learning for pre-service teachers in a technology-rich environment" (Latham & Carr, 2012) appeared in the "Journal of Learning Design," Volume 5, Issue 1 in 2012. Since writing this paper three years ago, the authors reflect upon and brainstorm what they describe here as a radically revised approach.…

  12. Circles of Change Revisited: Building Leadership, Scholarship and Professional Identity in the Children's Services Sector

    ERIC Educational Resources Information Center

    Macfarlane, Kym; Cartmel, Jennifer

    2012-01-01

    The field of children's services in Australia is currently undergoing significant change. For example, the current implementation of the Early Years Reform Agenda encompasses the development of National Quality Standards, which promote a strong focus on workforce development. As a consequence, practitioners in this sector are being required to…

  13. docBUILDER - Building Your Useful Metadata for Earth Science Data and Services.

    NASA Astrophysics Data System (ADS)

    Weir, H. M.; Pollack, J.; Olsen, L. M.; Major, G. R.

    2005-12-01

    The docBUILDER tool, created by NASA's Global Change Master Directory (GCMD), assists the scientific community in efficiently creating quality data and services metadata. Metadata authors are asked to complete five required fields to ensure enough information is provided for users to discover the data and related services they seek. After the metadata record is submitted to the GCMD, it is reviewed for semantic and syntactic consistency. Currently, two versions are available - a Web-based tool accessible with most browsers (docBUILDERweb) and a stand-alone desktop application (docBUILDERsolo). The Web version is available through the GCMD website, at http://gcmd.nasa.gov/User/authoring.html. This version has been updated and now offers: personalized templates to ease entering similar information for multiple data sets/services; automatic population of Data Center/Service Provider URLs based on the selected center/provider; three-color support to indicate required, recommended, and optional fields; an editable text window containing the XML record, to allow for quick editing; and improved overall performance and presentation. The docBUILDERsolo version offers the ability to create metadata records on a computer wherever you are. Except for installation and the occasional update of keywords, data/service providers are not required to have an Internet connection. This freedom will allow users with portable computers (Windows, Mac, and Linux) to create records in field campaigns, whether in Antarctica or the Australian Outback. This version also offers a spell-checker, in addition to all of the features found in the Web version.

  14. Service learning: a vehicle for building health equity and eliminating health disparities.

    PubMed

    Sabo, Samantha; de Zapien, Jill; Teufel-Shone, Nicolette; Rosales, Cecilia; Bergsma, Lynda; Taren, Douglas

    2015-03-01

    Service learning (SL) is a form of community-centered experiential education that places emerging health professionals in community-generated service projects and provides structured opportunities for reflection on the broader social, economic, and political contexts of health. We describe the elements and impact of five distinct week-long intensive SL courses focused on the context of urban, rural, border, and indigenous health contexts. Students involved in these SL courses demonstrated a commitment to community-engaged scholarship and practice in both their student and professional lives. SL is directly in line with the core public health value of social justice and serves as a venue to strengthen community-campus partnerships in addressing health disparities through sustained collaboration and action in vulnerable communities. PMID:25706014

  15. USAF engineering and service roles in space operations - Building the foundation for our future space infrastructure

    NASA Astrophysics Data System (ADS)

    Martin, Robert J.

    The USAF Engineering and Services (E&S) is described in terms of its activities that support ground stations, launch bases, and space-based facilities. E&S is structured according to a master plan for space support and exploitation which includes infrastructure operations and management, infrastructure acquisition, environmental protection, and technology transfer. Also included in the E&S masterplan are personnel education and development, human services, and readiness objectives for the support of space operations and general USAF operations. The USAF E&S operations are expected to support the modernization of space-launch and -range infrastructure, develop training methods and personnel for space support, and improve traditional E&S support technologies and techniques.

  16. Lesson Study-Building Communities of Learning Among Pre-Service Science Teachers

    NASA Astrophysics Data System (ADS)

    Hamzeh, Fouada

    Lesson Study is a widely used pedagogical approach that has been used for decades in its country of origin, Japan. It is a teacher-led form of professional development that involves the collaborative efforts of teachers in co-planning and observing the teaching of a lesson within a unit for evidence that the teaching practices used help the learning process (Lewis, 2002a). The purpose of this research was to investigate if Lesson Study enables pre-service teachers to improve their own teaching in the area of science inquiry-based approaches. Also explored are the self-efficacy beliefs of one group of science pre-service teachers related to their experiences in Lesson Study. The research investigated four questions: 1) Does Lesson Study influence teacher preparation for inquiry-based instruction? 2) Does Lesson Study improve teacher efficacy? 3) Does Lesson Study impact teachers' aspiration to collaborate with colleagues? 4) What are the attitudes and perceptions of pre-service teachers to the Lesson Study idea in Science? The 12 participants completed two pre- and post-study surveys: STEBI- B, Science Teaching Efficacy Belief Instrument (Enochs & Riggs, 1990) and ASTQ, Attitude towards Science Teaching. Data sources included student teaching lesson observations, lesson debriefing notes and focus group interviews. Results from the STEBI-B show that all participants measured an increase in efficacy throughout the study. This study added to the body of research on teaching learning communities, professional development programs and teacher empowerment.

  17. Child Care Services and the NYS Uniform Fire Prevention and Building Code: A Building Code Examination of Child Day Care Services Which Are Regulated by the NYS Department of Social Services with Particular Attention to Day Care Centers and the Role of the Local Authority Having Jurisdiction.

    ERIC Educational Resources Information Center

    New York State Div. of Code Enforcement and Administration, Albany.

    This course manual details the Uniform Fire Prevention and Building Code of New York State and how it affects child care services, particularly day care centers. The sections of the manual, each detailing a part of the code, are: (1) Introduction, Scope, Registration, and Definitions and Facilities Regulated by the New York Department of Social…

  18. MEDLINEplus: building and maintaining the National Library of Medicine's consumer health Web service

    PubMed Central

    Miller, Naomi; Lacroix, Eve-Marie; Backus, Joyce E. B.

    2000-01-01

    MEDLINEplus is a Web-based consumer health information resource, made available by the National Library of Medicine (NLM). MEDLINEplus has been designed to provide consumers with a well-organized, selective Web site facilitating access to reliable full-text health information. In addition to full-text resources, MEDLINEplus directs consumers to dictionaries, organizations, directories, libraries, and clearinghouses for answers to health questions. For each health topic, MEDLINEplus includes a preformulated MEDLINE search created by librarians. The site has been designed to match consumer language to medical terminology. NLM has used advances in database and Web technologies to build and maintain MEDLINEplus, allowing health sciences librarians to contribute remotely to the resource. This article describes the development and implementation of MEDLINEplus, its supporting technology, and plans for future development. PMID:10658959

  19. Building an effective competitive intelligence system for health care service providers.

    PubMed

    Festervand, T A; Lumpkin, J R

    1990-01-01

    With the increasing competitiveness of the health care marketplace, the need for information by service providers has increased concomitantly. In response to this need, strategic and competitive intelligence systems have emerged as a vital source of information. This article establishes a basis for the development and operation of a competitive intelligence system. Initially, strategic and competitive intelligence systems are conceptualized, then followed by a discussion of the areas which are candidates for inclusion in the intelligence system. The remainder of the article focuses on system development and operation. Attention also is directed toward information utilization and integration. PMID:10106847

  20. Silencing clusterin gene transcription on effects of multidrug resistance reversing of human hepatoma HepG2/ADM cells.

    PubMed

    Zheng, Wenjie; Sai, Wenli; Yao, Min; Gu, Hongbin; Yao, Yao; Qian, Qi; Yao, Dengfu

    2015-05-01

    Abnormal clusterin (CLU) expression is associated with multidrug resistance (MDR) of hepatocellular carcinoma (HCC). In the present study, the CLU expression was analyzed in human hepatoma cells and chemoresistant counterpart HepG2/ADM cells. Compared with L02 cells, the overexpression of cellular CLU was identified in HepG2, HepG2/ADM, SMMC7721, Hep3B ,and PLC cells and relatively lower expression in Bel-7404, SNU-739, and MHCC97H cells. Specific short hairpin RNAs (shRNAs) to silence CLU gene transcription were designed, and the most effective sequences were screened. After the HepG2/ADM cells transfected with shRNA-1, the inhibition of CLU expression was 73.68 % at messenger RNA (mRNA) level by real-time quantitative RT-PCR with obvious enhancement in cell chemosensitivity, increasing apoptosis induced by doxorubicin using fluorescence kit, and Rh-123 retention qualified with flow cytometry. Knockdown CLU also significantly decreased the drug efflux pump activity through the depression of MDR1/P-glycoprotein (q = 11.739, P < 0.001). Moreover, silencing CLU led to downregulation of β-catenin (q = 13.544, P = 0.001), suggesting that downregulation of CLU might be a key point to reverse multidrug resistance of HepG2/ADM cells. PMID:25600802

  1. Induction of apoptosis and reversal of permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM by ginsenoside Rh2

    PubMed Central

    Zhang, Hui; Gong, Jian; Zhang, Huilai; Kong, Di

    2015-01-01

    Multidrug resistance is a phenomenon that cancer cells develop a cross-resistant phenotype against several unrelated drugs, and permeability glycoprotein derived from the overexpression of multidrug resistance gene 1 has been taken as the most significant cause of multidrug resistance. In the present study, ginsenoside Rh2 was used to reverse permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM cell line. Effects of ginsenoside Rh2 on the apoptotic process and caspase-3 activity of MCF-7 and MCF-7/ADM cell lines were determined using flow cytometry and microplate reader. Methyl thiazolyl tetrazolium test was conducted to assess the IC50 values of ginsenoside Rh2 and adriamycin on MCF-7 and MCF-7/ADM cultures; Rhodamin 123 assay was used to assess the retention of permeability glycoprotein after ginsenoside Rh2 treatment; flow cytometry and real time polymerase chain reaction were used to determine the expression levels of permeability glycoprotein and multidrug resistance gene 1 in drug-resistant cells and their parental cells after exposure to ginsenoside Rh2. The results showed that ginsenoside Rh2, except for inducing apoptosis, had the ability to reverse multidrug resistance in MCF-7/ADM cell line without changing the expression levels of permeability glycoprotein and multidrug resistance gene 1. Our findings provided some valuable information for the application of ginsenoside Rh2 in cancer therapy, especially for multidrug resistance reversal in clinic. PMID:26191135

  2. Agile enterprise development framework utilizing services principles for building pervasive security

    NASA Astrophysics Data System (ADS)

    Farroha, Deborah; Farroha, Bassam

    2011-06-01

    We are in an environment of continuously changing mission requirements and therefore our Information Systems must adapt to accomplish new tasks, quicker, in a more proficient manner. Agility is the only way we will be able to keep up with this change. But there are subtleties that must be considered as we adopt various agile methods: secure, protect, control and authenticate are all elements needed to posture our Information Technology systems to counteract the real and perceived threats in today's environment. Many systems have been tasked to ingest process and analyze different data sets than they were originally designed for and they have to interact with multiple new systems that were unaccounted for at design time. Leveraging the tenets of security, we have devised a new framework that takes agility into a new realm where the product will built to work in a service-based environment but is developed using agile processes. Even though these two criteria promise to hone the development effort, they actually contradict each other in philosophy where Services require stable interfaces, while Agile focuses on being flexible and tolerate changes up to much later stages of development. This framework is focused on enabling a successful product development that capitalizes on both philosophies.

  3. Performance optimization and validation of ADM1 simulations under anaerobic thermophilic conditions.

    PubMed

    Atallah, Nabil M; El-Fadel, Mutasem; Ghanimeh, Sophia; Saikaly, Pascal; Abou-Najm, Majdi

    2014-12-01

    In this study, two experimental sets of data each involving two thermophilic anaerobic digesters treating food waste, were simulated using the Anaerobic Digestion Model No. 1 (ADM1). A sensitivity analysis was conducted, using both data sets of one digester, for parameter optimization based on five measured performance indicators: methane generation, pH, acetate, total COD, ammonia, and an equally weighted combination of the five indicators. The simulation results revealed that while optimization with respect to methane alone, a commonly adopted approach, succeeded in simulating methane experimental results, it predicted other intermediary outputs less accurately. On the other hand, the multi-objective optimization has the advantage of providing better results than methane optimization despite not capturing the intermediary output. The results from the parameter optimization were validated upon their independent application on the data sets of the second digester. PMID:25463805

  4. Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery.

    PubMed

    Samiulla, D S; Vaidyanathan, V V; Arun, P C; Balan, G; Blaze, M; Bondre, S; Chandrasekhar, G; Gadakh, A; Kumar, R; Kharvi, G; Kim, H O; Kumar, S; Malikayil, J A; Moger, M; Mone, M K; Nagarjuna, P; Ogbu, C; Pendhalkar, D; Rao, A V S Raja; Rao, G Venkateshwar; Sarma, V K; Shaik, S; Sharma, G V R; Singh, S; Sreedhar, C; Sonawane, R; Timmanna, U; Hardy, L W

    2005-01-01

    Natural product analogs are significant sources for therapeutic agents. To capitalize efficiently on the effective features of naturally occurring substances, a natural product-based library production platform has been devised at Aurigene for drug lead discovery. This approach combines the attractive biological and physicochemical properties of natural product scaffolds, provided by eons of natural selection, with the chemical diversity available from parallel synthetic methods. Virtual property analysis, using computational methods described here, guides the selection of a set of natural product scaffolds that are both structurally diverse and likely to have favorable pharmacokinetic properties. The experimental characterization of several in vitro ADME properties of twenty of these scaffolds, and of a small set of designed congeners based upon one scaffold, is also described. These data confirm that most of the scaffolds and the designed library members have properties favorable to their utilization for creating libraries of lead-like molecules. PMID:15789560

  5. New Materials for the Undergraduate Classroom to Build Pre-Service Teachers' NGSS Skills and Knowledge

    NASA Astrophysics Data System (ADS)

    Egger, A. E.; Awad, A. A.; Baldwin, K. A.; Birnbaum, S. J.; Bruckner, M. Z.; DeBari, S. M.; Dechaine, J.; Ebert, J. R.; Gray, K. R.; Hauge, R.; Linneman, S. R.; Monet, J.; Thomas, J.; Varrella, G.

    2014-12-01

    As part of InTeGrate, teams of 3 instructors at 3 different institutions developed modules that help prepare pre-service teachers to teach Earth science aligned with the NGSS. Modules were evaluated against a rubric, which addresses InTeGrate's five guiding principles, learning objectives and outcomes, assessment and measurement, resources and materials, instructional strategies and alignment. As all modules must address one or more Earth-related grand challenge facing society, develop student ability to address interdisciplinary problems, improve student understanding of the methods of geoscience, use authentic geoscience data, and incorporate systems thinking, they align well with the NGSS. Once modules passed the rubric, they were tested by the authors in their classrooms. Testing included pre- and post-assessment of geoscience literacy and assessment of student learning towards the module goal; materials were revised based on the results of testing. In "Exploring Geoscience Methods with Secondary Education Students," pre-service science teachers compare geoscientific thinking with the classic (experimental) scientific method, investigate global climate change and its impacts on human systems, and prepare an interdisciplinary lesson plan that addresses geoscience methods in context of a socioscientific issue. In "Soils and Society," pre-service elementary teachers explore societal issues where soil is important, develop skills to describe and test soil properties, and create a standards-based Soils and Society Kit that consists of lessons and supporting materials to teach K-8 students about a soil-and-society issue. In "Interactions between Water, Earth's Surface, and Human Activity," students explore the effects of running water on shaping Earth's surface both over geologic time and through short-term flooding events, and produce a brochure to inform citizens of the impact of living near a river. The modules are freely available at http

  6. Constructing CoRes—a Strategy for Building PCK in Pre-service Science Teacher Education

    NASA Astrophysics Data System (ADS)

    Hume, Anne; Berry, Amanda

    2011-05-01

    This paper presents findings from an exploratory study into a science teacher education initiative that seeks to build the foundations on which novice teachers can begin developing their pedagogical content knowledge (PCK). The initiative involved the use of Content Representations (CoRes), which were originally developed as part of a strategy for exploring and gaining insights into the PCK of expert science teachers. As the student teachers explored existing CoRes the course lecturer saw potential for more effectively developing their PCK through engaging them in constructing their own CoRes for new topics. When given the opportunity, student teachers found the task challenging and their lack of classroom experience and experimentation proved to be a limiting factor. However, the contribution such a task could make to their future PCK development remained a distinct possibility in the lecturer's view. In the following year she carefully scaffolded the learning prior to CoRe construction such that the student teachers could more readily access relevant knowledge when attempting such a task. Their resultant CoRes and comments indicate that with appropriate and timely scaffolding the process of CoRe construction does have the potential for PCK development for novice teachers.

  7. Building the Capacity for Climate Services: Thoughts on Training Next Generation Climate Science Integrators

    NASA Astrophysics Data System (ADS)

    Garfin, G. M.; Brugger, J.; Gordon, E. S.; Barsugli, J. J.; Rangwala, I.; Travis, W.

    2015-12-01

    For more than a decade, stakeholder needs assessments and reports, including the recent National Climate Assessment, have pointed out the need for climate "science translators" or "science integrators" who can help bridge the gap between the cultures and contexts of researchers and decision-makers. Integration is important for exchanging and enhancing knowledge, building capacity to use climate information in decision making, and fostering more robust planning for decision-making in the context of climate change. This talk will report on the characteristics of successful climate science integrators, and a variety of models for training the upcoming generation of climate science integrators. Science integration characteristics identified by an experienced vanguard in the U.S. include maintaining credibility in both the scientific and stakeholder communities, a basic respect for stakeholders demonstrated through active listening, and a deep understanding of the decision-making context. Drawing upon the lessons of training programs for Cooperative Extension, public health professionals, and natural resource managers, we offer ideas about training next generation climate science integrators. Our model combines training and development of skills in interpersonal relations, communication of science, project implementation, education techniques and practices - integrated with a strong foundation in disciplinary knowledge.

  8. Geoinformatics in the public service: building a cyberinfrastructure across the geological surveys

    USGS Publications Warehouse

    Allison, M. Lee; Gundersen, Linda C.; Richard, Stephen M.

    2011-01-01

    Advanced information technology infrastructure is increasingly being employed in the Earth sciences to provide researchers with efficient access to massive central databases and to integrate diversely formatted information from a variety of sources. These geoinformatics initiatives enable manipulation, modeling and visualization of data in a consistent way, and are helping to develop integrated Earth models at various scales, and from the near surface to the deep interior. This book uses a series of case studies to demonstrate computer and database use across the geosciences. Chapters are thematically grouped into sections that cover data collection and management; modeling and community computational codes; visualization and data representation; knowledge management and data integration; and web services and scientific workflows. Geoinformatics is a fascinating and accessible introduction to this emerging field for readers across the solid Earth sciences and an invaluable reference for researchers interested in initiating new cyberinfrastructure projects of their own.

  9. Building on Family Strengths: Research and Services in Support of Children and Their Families. Proceedings of the Building on Family Strengths Annual Conference (14th, Portland, Oregon, May 31-June 2, 2007) and State of the Science Report

    ERIC Educational Resources Information Center

    Swart, Sandra, Ed.; Friesen, Barbara, Ed.; Holman, Ariel, Ed.; Aue, Nicole, Ed.

    2009-01-01

    The State of the Science conference was held in May, 2007 as part of the ongoing series of national conferences, "Building on Family Strengths," conducted by the Research and Training Center on Family Support and Children's Mental Health at Portland State University. The theme of this State-of-the Science conference was "Effective services for all…

  10. Building the national health information infrastructure for personal health, health care services, public health, and research

    PubMed Central

    Detmer, Don E

    2003-01-01

    Background Improving health in our nation requires strengthening four major domains of the health care system: personal health management, health care delivery, public health, and health-related research. Many avoidable shortcomings in the health sector that result in poor quality are due to inaccessible data, information, and knowledge. A national health information infrastructure (NHII) offers the connectivity and knowledge management essential to correct these shortcomings. Better health and a better health system are within our reach. Discussion A national health information infrastructure for the United States should address the needs of personal health management, health care delivery, public health, and research. It should also address relevant global dimensions (e.g., standards for sharing data and knowledge across national boundaries). The public and private sectors will need to collaborate to build a robust national health information infrastructure, essentially a 'paperless' health care system, for the United States. The federal government should assume leadership for assuring a national health information infrastructure as recommended by the National Committee on Vital and Health Statistics and the President's Information Technology Advisory Committee. Progress is needed in the areas of funding, incentives, standards, and continued refinement of a privacy (i.e., confidentiality and security) framework to facilitate personal identification for health purposes. Particular attention should be paid to NHII leadership and change management challenges. Summary A national health information infrastructure is a necessary step for improved health in the U.S. It will require a concerted, collaborative effort by both public and private sectors. If you cannot measure it, you cannot improve it. Lord Kelvin PMID:12525262

  11. ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans.

    PubMed Central

    Podbilewicz, B

    1996-01-01

    A search was carried out for homologues of possible fusogenic proteins to study their function in a genetically tractable animal. The isolation, molecular, and cellular characterization of the Caenorhabditis elegans adm-1 gene (a disintegrin and metalloprotease domain) are described. A glycoprotein analogous to viral fusion proteins has been identified on the surface of guinea pig sperm (PH-30/fertilin) and is implicated in sperm-egg fusion. adm-1 is the first reported invertebrate gene related to PH-30 and a family of proteins containing snake venom disintegrin- and metalloprotease-like domains. ADM-1 shows a domain organization identical to PH-30. It contains prepro, metalloprotease, disintegrin, cysteine rich with putative fusion peptide, epidermal growth factor-like repeat, transmembrane, and cytoplasmic domains. Antibodies which recognize ADM-1 protein in immunoblots were generated. Using immunofluorescence and in situ hybridization, the products of adm-1 have been detected in specific cells during different stages of development. The localization of ADM-1 to the plasma membrane of embryonic cells and to the sheath cells of sensory organs suggests a function in cell adhesion. ADM-1 expression in the hypodermis, pharynx, vulva, and mature sperm is consistent with a putative role in somatic and gamete cell fusions. Images PMID:8970152

  12. Eduserv - the Education Service of Eurosdr: Sharing Experience for Capacity Building

    NASA Astrophysics Data System (ADS)

    Fritsch, D.; Mooney, K.; Oestman, A.

    2012-07-01

    This paper describes EduServ, the Education Service of EuroSDR - a European spatial data research organisation whose aim is to address the research needs of spatial data provision in Europe. With a current membership coming from seventeen European countries and a strong working relationship with related European organisations, EuroSDR has amassed considerable experience in addressing the extent and nature of this need. In order to facilitate the transfer of outcomes of EuroSDR research activities to the user domain, e.g. to key personnel in geographic information (GI) production organisations and industry, EuroSDR commenced this annual series of elearning courses in 2002. The Internet courses are preceded by a seminar at which participants meet tutors and receive guidelines for following the courses from their own locations. Delivery of the two-week courses requires an acceptable level of Internet connectivity, which exists in most member countries. EuroSDR is aware, however, that should such courses be shared internationally, other forms of communication will need to be addressed, such as satellite broadcasting. This would require effective collaboration with related organisations with experience with this means of communication. EduServ courses are offered in two successive years. During the courses, participants enjoy access to course tutors with a 24-hour response to queries guaranteed. Thereafter, course material for these courses is made available online. EuroSDR continues to work with past course tutors to ensure that this valuable resource is maintained as an effective and sustainable archive. This paper is aimed at sharing EuroSDR's experience in distance education with the wider scientific community with a view to its applicability to a global audience, whereby instead of sharing expertise within the GI community in Europe, European mapping agencies can share their knowledge and experience with the international GI community.

  13. The Swiss Seismological Service in Greenland: Network Building and Research Initiatives

    NASA Astrophysics Data System (ADS)

    Husen, S.; Clinton, J. F.; Olivieri, M.; Giardini, D.

    2010-12-01

    In recent years the Swiss Seismological Service (SED) at the ETH Zürich has begun active work in NW Greenland. As part of the GreenLand Ice Sheet monitoring Network (GLISN), a new international, broadband seismic capability for Greenland, the SED has installed 3 observation quality stations, recording in realtime, with data freely open to the community. Each site is located at a village - two are within 60km of productive calving glacier fronts (Rink and Jakobshavn); the other station is 30km from inland ice calving directly into the ocean. This paper presents the stations and discusses the data quality. The capability of broadband seismic sensors at local distances to record a wide spectrum of ground motion induced by large calving events is becoming clear. Associated with a major calving event, we observe energy at 1. high frequencies (1-5Hz) due to ice fracture; 2. at mid periods (40-60s - visible at teleseismic distances) likely due to large, rapid displacement of the calved ice across the fjord floor; and 3. at longer periods (100-1000s) measuring fjord seiche generated by the calved iceberg. We are developing an automated detector for events using the GLISN dataset, with focus on the Swiss stations. Additionally, the SED, with the ETH Glaciology unit, intend to operate a broadband / short period seismic network on the ice near SwissCamp in summer 2011. The goal is to improve understanding of how sub-glacial water affects glacial bed coupling. We aim to generate an icequake catalogue with characterized sources, and to model transient changes in ice structure than may be indicative of water flow. We present a summary of the proposed work and installation plans.

  14. Community Building Services Training Program: A Model Training Program to Provide Technical Training for Minority Adults in Construction, Building Maintenance,and Property Management. Final Report.

    ERIC Educational Resources Information Center

    Community Building Maintenance Corp., Chicago, IL.

    A demonstration program, administered by a community based building maintenance, management, and construction corporation, was developed to provide technical training for minority adults in construction, building maintenance, and property management in the Chicago area. The program was concerned with seeking solutions to the lack of housing, job…

  15. Service Life Assessment of Historical Building Envelopes Constructed Using Different Types of Sandstone: A Computational Analysis Based on Experimental Input Data

    PubMed Central

    Kočí, Václav; Maděra, Jiří; Fořt, Jan; Žumár, Jaromír; Pavlíková, Milena; Pavlík, Zbyšek; Černý, Robert

    2014-01-01

    Service life assessment of three historical building envelopes constructed using different types of sandstone is presented. At first, experimental measurements of material parameters of sandstones are performed to provide the necessary input data for a subsequent computational analysis. In the second step, the moisture and temperature fields across the studied envelopes are calculated for a representative period of time. The computations are performed using dynamic climatic data as the boundary conditions on the exterior side of building envelope. The climatic data for three characteristic localities are experimentally determined by the Czech Hydrometeorological Institute and contain hourly values of temperature, relative humidity, rainfalls, wind velocity and direction, and sun radiation. Using the measured durability properties of the analyzed sandstones and the calculated numbers of freeze/thaw cycles under different climatic conditions, the service life of the investigated building envelopes is assessed. The obtained results show that the climatic conditions can play a very significant role in the service life assessment of historical buildings, even in the conditions of such a small country as the Czech Republic. In addition, the investigations reveal the importance of the material characteristics of sandstones, in particular the hygric properties, on their service life in a structure. PMID:25114972

  16. Service life assessment of historical building envelopes constructed using different types of sandstone: a computational analysis based on experimental input data.

    PubMed

    Kočí, Václav; Maděra, Jiří; Fořt, Jan; Žumár, Jaromír; Pavlíková, Milena; Pavlík, Zbyšek; Černý, Robert

    2014-01-01

    Service life assessment of three historical building envelopes constructed using different types of sandstone is presented. At first, experimental measurements of material parameters of sandstones are performed to provide the necessary input data for a subsequent computational analysis. In the second step, the moisture and temperature fields across the studied envelopes are calculated for a representative period of time. The computations are performed using dynamic climatic data as the boundary conditions on the exterior side of building envelope. The climatic data for three characteristic localities are experimentally determined by the Czech Hydrometeorological Institute and contain hourly values of temperature, relative humidity, rainfalls, wind velocity and direction, and sun radiation. Using the measured durability properties of the analyzed sandstones and the calculated numbers of freeze/thaw cycles under different climatic conditions, the service life of the investigated building envelopes is assessed. The obtained results show that the climatic conditions can play a very significant role in the service life assessment of historical buildings, even in the conditions of such a small country as the Czech Republic. In addition, the investigations reveal the importance of the material characteristics of sandstones, in particular the hygric properties, on their service life in a structure. PMID:25114972

  17. 41 CFR 102-79.25 - May Federal agencies allot space in Federal buildings for the provision of child care services?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false May Federal agencies allot space in Federal buildings for the provision of child care services? 102-79.25 Section 102-79.25 Public Contracts and Property Management Federal Property Management Regulations System...

  18. 41 CFR 102-79.25 - May Federal agencies allot space in Federal buildings for the provision of child care services?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May Federal agencies allot space in Federal buildings for the provision of child care services? 102-79.25 Section 102-79.25 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY...

  19. Characterization of in vitro ADME properties of diosgenin and dioscin from Dioscorea villosa.

    PubMed

    Manda, Vamshi K; Avula, Bharathi; Ali, Zulfiqar; Wong, Yan-Hong; Smillie, Troy J; Khan, Ikhlas A; Khan, Shabana I

    2013-10-01

    Dioscorea villosa (wild yam) is native to North America and has been widely used as a natural alternative for estrogen replacement therapy to improve women's health as well as to treat inflammation, muscle spasm, and asthma. Diosgenin and dioscin (glycoside form of diosgenin) are reported to be the pharmacologically active compounds. Despite the reports of significant pharmacological properties of dioscin and diosgenin in conditions related to inflammation, cancer, diabetes, and gastrointestinal ailments, no reports are available on ADME properties of these compounds. This study was carried out to determine ADME properties of diosgenin and dioscin and their effects on major drug metabolizing enzymes (CYP 3A4, 2D6, 2C9, and 1A2). The stability was determined in simulated gastric and intestinal fluids (SGF, pH 1.2 and SIF, pH 6.8), and intestinal transport was evaluated in Caco-2 model. Phase I and phase II metabolic stability was determined in human liver microsomes and S9 fractions, respectively. Quantitative analysis of dioscin and diosgenin was performed by UPLC-MS system. Dioscin degraded up to 28.3 % in SGF and 12.4 % in SIF, which could be accounted for by its conversion to diosgenin (24.2 %. in SGF and 2.4 % in SIF). The depletion of diosgenin in SGF and SIF was < 10 %. Diosgenin was stable in HLM but disappeared in S9 fraction with a half-life of 11.3 min. In contrast, dioscin was stable in both HLM and S9 fractions. Dioscin showed higher permeability across Caco-2 monolayer with no significant efflux, while diosgenin was subjected to efflux mediated by P-glycoprotein. Diosgenin and dioscin inhibited CYP3A4 with IC50 values of 17 and 33 µM, respectively, while other CYP enzymes were not affected. In conclusion, dioscin showed better intestinal permeability. Conversion of dioscin to diosgenin was observed in both gastric and intestinal fluids. No phase I metabolism was detected for both compounds. The disappearance of diosgenin in S9 fraction indicated phase

  20. Building 1100--NASA

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Building 1100 is the NASA administrative building. Services located in this building include two banks, a post office, barber shop, cafeteria, snack bar, travel agency, dry cleaners, the NASA Exchange retail store and medical facilities for employees.

  1. Interventions in Organizational and Community Context: A Framework for Building Evidence on Dissemination and Implementation in Health Services Research

    PubMed Central

    Mendel, Peter; Meredith, Lisa S.; Schoenbaum, Michael; Sherbourne, Cathy D.; Wells, Kenneth B.

    2013-01-01

    The effective dissemination and implementation of evidence-based health interventions within community settings is an important cornerstone to expanding the availability of quality health and mental health services. Yet it has proven a challenging task for both research and community stakeholders. This paper presents the current framework developed by the UCLA/RAND NIMH Center to address this research-to-practice gap by: 1) providing a theoretically-grounded understanding of the multi-layered nature of community and healthcare contexts and the mechanisms by which new practices and programs diffuse within these settings; 2) distinguishing among key components of the diffusion process—including contextual factors, adoption, implementation, and sustainment of interventions—showing how evaluation of each is necessary to explain the course of dissemination and outcomes for individual and organizational stakeholders; 3) facilitating the identification of new strategies for adapting, disseminating, and implementing relatively complex, evidence-based healthcare and improvement interventions, particularly using a community-based, participatory approach; and 4) enhancing the ability to meaningfully generalize findings across varied interventions and settings to build an evidence base on successful dissemination and implementation strategies. PMID:17990095

  2. Thermal pretreatment and hydraulic retention time in continuous digesters fed with sewage sludge: assessment using the ADM1.

    PubMed

    Souza, Theo S O; Ferreira, Liliana Catarina; Sapkaite, Ieva; Pérez-Elvira, Sara I; Fdz-Polanco, Fernando

    2013-11-01

    Thermal pretreatment is an interesting technique not only for increasing sludge biodegradability, leading to higher methane productivity, but also for improving degradation rates, allowing full-scale plants to reduce the size of digesters. In this study, the Anaerobic Digestion Model No. 1 (ADM1) was used as a tool to assess the effects of thermal pretreatment and hydraulic retention time (HRT) on the performance of three pilot-scale digesters fed with mixed sludge with/without pretreatment applied to the waste activated sludge fraction. Calibration procedures using batch tests showed an increase of up to five times in the model disintegration coefficient due to the pretreatment, and the validations performed presented good accuracy with the experimental data, with under/overestimation lower than 15% in both average and global accumulated CH4 productions. Therefore, the ADM1 demonstrated its feasibility and usefulness in predicting and assessing the behavior of the digesters under these conditions. PMID:24063816

  3. Dust in the York canonical basis of ADM tetrad gravity: The problem of vorticity

    NASA Astrophysics Data System (ADS)

    Alba, David; Lusanna, Luca

    2015-05-01

    Brown's formulation of dynamical perfect fluids in Minkowski space-time is extended to ADM tetrad gravity in globally hyperbolic, asymptotically Minkowskian space-times. For the dust, we get the Hamiltonian description in closed form in the York canonical basis, where we can separate the inertial gauge variables of the gravitational field in the non-Euclidean 3-spaces of global non-inertial frames from the physical tidal ones. After writing the Hamilton equations of the dust, we identify the sector of irrotational motions and the gauge fixings forcing the dust 3-spaces to coincide with the 3-spaces of the non-inertial frame. The role of the inertial gauge variable York time (the remnant of the clock synchronization gauge freedom) is emphasized. Finally, the Hamiltonian Post-Minkowskian linearization is studied. This formalism is required when one wants to study the Hamiltonian version of cosmological models (for instance back-reaction as an alternative to dark energy) in the York canonical basis.

  4. Development of an ADME and drug-drug interactions knowledge database for the acceleration of drug discovery and development.

    PubMed

    Petitet, François; Barberan, Olivier; Dubus, Elodie; Ijjaali, Ismail; Donlan, Mary; Ollivier, Sophie; Michel, André

    2006-12-01

    It is widely recognised that predicting or determining the absorption, distribution, metabolism and excretion (ADME) properties of a compound as early as possible in the drug discovery process helps to prevent costly late-stage failures. Although in recent years high-throughput in vitro absorption distribution metabolism excretion toxicity (ADMET) screens have been implemented, more efficient in silico filters are still highly needed to predict and model the most relevant metabolic and pharmacokinetic end points, and thereby accelerate drug discovery and development. The usefulness of the data generated and published for the chemist, biologist or project manager who ultimately wants to understand and optimise the ADME properties of lead compounds cannot be argued with. Collecting and comparing data is an overwhelming task for the time-pressed scientist. Aureus Pharma provides a uniquely specialised solution for knowledge generation in drug discovery. AurSCOPE(®) ADME/DDI (drug-drug interaction) is a fully annotated, structured knowledge database containing all the pertinent biological and chemical information on the metabolic properties of drugs. This Aureus knowledge database has proven to be highly useful in designing predictive models and identifying potential drug-drug interactions. PMID:23495997

  5. Planning Library Buildings for Service. Proceedings of a Library Buildings and Equipment Institute (Kent State University, Ohio, July 6-8, 1961).

    ERIC Educational Resources Information Center

    Roth, Harold L., Ed.

    The text is made up of a number of general papers followed by the presentations of specific plans of college and university, public, and school libraries. The general sessions were devoted to areas of common interest to anyone contemplating a library program. Topics discussed include--(1) elements in planning a library building program, (2)…

  6. Role of iodine in the toxicity of diiodomethyl-p-tolylsulfone (DIMPTS) in rats: ADME.

    PubMed

    Saghir, Shakil A; Yano, Barry L; Zablotny, Carol L; Brzak, Kathy A; Clark, Amy J; Staley, Jennifer L

    2012-04-01

    Metabolism of diiodomethyl-p-tolylsulfone (DIMPTS) was investigated in rats to determine the role of iodide in its toxicity. Fischer 344 (F-344) (5 or 50mg/kg) or Sprague Dawley (SD) (5mg/kg) rats were gavaged with (14)C-DIMPTS or dermally applied with 5mg/kg (F-344 only) and absorption, distribution, metabolism and excretion (ADME) determined. Additional experiments were conducted with its deiodinated analog (methyl-p-tolylsulfone, MPTS) in female F-344 rats (20mg/kg) for comparison. Orally administered (14)C-DIMPTS was rapidly absorbed and eliminated in urine (92%). The elimination t(½) was 1-4h. Dermally applied (14)C-DIMPTS remained undetectable in plasma with bioavailability ≈ 7%, only 5-7% of the dose was recovered in urine. DIMPTS liberated one or both of its iodine atoms upon absorption. The rate of elimination of the liberated iodide from the systemic circulation was 2- to 3-fold slower in SD than F-344 rats, which resulted in higher bioavailability of iodide to SD rats. DIMPTS was primarily oxidized at the benzylic methyl moiety forming the corresponding benzoic acid. Glutathione conjugation on the sulfonyl methyl group, via displacement of I(-) was also observed. Overall 67-80% of the total iodine atoms were metabolically released from DIMPTS. The MPTS was rapidly absorbed from the GI tract, metabolized and eliminated in urine similar to that of DIMPTS. These data were compared to iodide toxicokinetic results of a reproductive toxicity study for DIMPTS (80 mg/kg/day) and MPTS (32 mg/kg/day), where DIMPTS was toxic to dams and pups, while MPTS caused no toxicity. These data show that the liberated iodide is the ultimate toxicant of DIMPTS, which is readily transported to pups through milk, while the methyltolylsulfone backbone structure (MPTS) of DIMPTS is relatively nontoxic. PMID:21986257

  7. Models of evaluating efficiency and risks on integration of cloud-base IT-services of the machine-building enterprise: a system approach

    NASA Astrophysics Data System (ADS)

    Razumnikov, S.; Kurmanbay, A.

    2016-04-01

    The present paper suggests a system approach to evaluation of the effectiveness and risks resulted from the integration of cloud-based services in a machine-building enterprise. This approach makes it possible to estimate a set of enterprise IT applications and choose the applications to be migrated to the cloud with regard to specific business requirements, a technological strategy and willingness to risk.

  8. Utah's Bookmobile Counties in the Year 2000: Building on a Proven Foundation for Library and Information Services.

    ERIC Educational Resources Information Center

    Utah State Library Div., Salt Lake City. Dept. of Community and Economic Development.

    This discussion paper raises important issues for the future of Utah's public library services, specifically, the state's bookmobile service. Federal dollars used to support daily bookmobile operations in 22 counties will come to an end with the expiration of the "Library Services and Construction Act" in 1996. Beginning in 1997, the State Library…

  9. Nurturing the H in HR: Using Action Learning to Build Organisation Development Capability in the UK Civil Service

    ERIC Educational Resources Information Center

    Hale, Richard; Saville, Martin

    2014-01-01

    In the UK, the Civil Service Reform Plan is being implemented with urgency. This requires Civil Service departments and agencies to reform their structures and ways of working in order to deliver effective services in a climate of economic austerity and rapid social and technological change. Historically, Human Resource (HR) professionals have…

  10. Construyendo Puentes (Building Bridges): Concepts and Models for Service-Learning in Spanish. AAHE's Series on Service-Learning in the Disciplines.

    ERIC Educational Resources Information Center

    Hellebrandt, Josef, Ed.; Varona, Lucia T., Ed.

    This volume is part of a series of 18 monographs on service learning and the academic disciplines. It is designed to help teachers, administrators, and students realize the potential of service learning in Spanish. Following a Foreword by Carmen Chaves Tesser and an Introduction by Josef Hellebrandt and Lucia T. Varona, the four essays in Part 1,…

  11. Comparison of ADM and Connective Tissue Graft as the Membrane in Class II Furcation Defect Regeneration: A Randomized Clinical Trial

    PubMed Central

    Esfahanian, Vahid; Farhad, Shirin; Sadighi Shamami, Mehrnaz

    2014-01-01

    Background and aims. Furcally-involved teeth present unique challenges to the success of periodontal therapy and influence treatment outcomes. This study aimed to assess to compare use of ADM and connective tissue membrane in class II furcation defect regeneration. Materials and methods. 10 patient with 2 bilaterally class II furcation defects in first and/or second maxilla or man-dibular molar without interproximal furcation involvement, were selected. Four weeks after initial phase of treatment, before and thorough the surgery pocket depth (PD), clinical attachment level to stent (CAL-S), free gingival margin to stent(FGM-S) , crestal bone to stent (Crest-S), horizontal defect depth to stent (HDD-S) and vertical defect depth to stent (VDD-S) and crestal bone to defect depth measured from stent margin. Thereafter, one side randomly treated using connective tissue and DFDBA (study group) and opposite side received ADM and DFDBA (control group). After 6 months, soft and hard tissue parameters measured again in re-entry. Results. Both groups presented improvements after therapies (P & 0.05). No inter-group differences were seen in PD re-duction (P = 0.275), CAL gain (P = 0.156), free gingival margin (P = 0.146), crest of the bone (P = 0.248), reduction in horizontal defects depth (P = 0.139) and reduction in vertical defects depth (P = 0.149). Conclusion. Both treatments modalities have potential of regeneration without any adverse effect on healing process. Connective tissue grafts did not have significant higher bone fill compared to that of ADM. PMID:25093054

  12. CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2/ADM cells: in vitro and in vivo evaluation

    NASA Astrophysics Data System (ADS)

    Zhang, Gen; Shi, Lixin; Selke, Matthias; Wang, Xuemei

    2011-06-01

    Cadmium telluride quantum dots (Cdte QDs) have received significant attention in biomedical research because of their potential in disease diagnosis and drug delivery. In this study, we have investigated the interaction mechanism and synergistic effect of 3-mercaptopropionic acid-capped Cdte QDs with the anti-cancer drug daunorubicin (DNR) on the induction of apoptosis using drug-resistant human hepatoma HepG2/ADM cells. Electrochemical assay revealed that Cdte QDs readily facilitated the uptake of the DNR into HepG2/ADM cells. Apoptotic staining, DNA fragmentation, and flow cytometry analysis further demonstrated that compared with Cdte QDs or DNR treatment alone, the apoptosis rate increased after the treatment of Cdte QDs together with DNR in HepG2/ADM cells. We observed that Cdte QDs treatment could reduce the effect of P-glycoprotein while the treatment of Cdte QDs together with DNR can clearly activate apoptosis-related caspases protein expression in HepG2/ADM cells. Moreover, our in vivo study indicated that the treatment of Cdte QDs together with DNR effectively inhibited the human hepatoma HepG2/ADM nude mice tumor growth. The increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. Thus, Cdte QDs combined with DNR may serve as a possible alternative for targeted therapeutic approaches for some cancer treatments.

  13. Comparison of the complex terrain algorithms incorporated into two commonly used local-scale air pollution dispersion models (ADMS and AERMOD) using a hybrid model.

    PubMed

    Carruthers, David J; Seaton, Martin D; McHugh, Christine A; Sheng, Xiangyu; Solazzo, Efisio; Vanvyve, Emilie

    2011-11-01

    ADMS and AERMOD are the two most widely used dispersion models for regulatory purposes. It is, therefore, important to understand the differences in the predictions of the models and the causes of these differences. The treatment by the models of flat terrain has been discussed previously; in this paper the focus is on their treatment of complex terrain. The paper includes a discussion of the impacts of complex terrain on airflow and dispersion and how these are treated in ADMS and AERMOD, followed by calculations for two distinct cases: (i) sources above a deep valley within a relatively flat plateau area (Clifty Creek power station, USA); (ii) sources in a valley in hilly terrain where the terrain rises well above the stack tops (Ribblesdale cement works, England). In both cases the model predictions are markedly different. At Clifty Creek, ADMS suggests that the terrain markedly increases maximum surface concentrations, whereas the AERMOD complex terrain module has little impact. At Ribblesdale, AERMOD predicts very large increases (a factor of 18) in the maximum hourly average surface concentrations due to plume impaction onto the neighboring hill; although plume impaction is predicted by ADMS, the increases in concentration are much less marked as the airflow model in ADMS predicts some lateral deviation of the streamlines around the hill. PMID:22168106

  14. Technology: Collaboration in User Interface Design, or Bringing the Public Service Perspective to Building a Digital Library

    ERIC Educational Resources Information Center

    Harper, Corey A.

    2006-01-01

    As libraries increasingly look to give their collections a strong digital presence, many of the librarians involved come from traditionally technical services oriented areas: catalogers, systems librarians, web developers, and database specialists. Collaboration between representatives of public services, collection development, and technical…

  15. Root Metaphors, Paradigm Shifts, and Democratically Shared Values: Community Service-Learning as a Bridge-Building Endeavor

    ERIC Educational Resources Information Center

    Sheffield, Eric C.

    2007-01-01

    This paper claims that community service-learning (CSL) projects in schools and universities, if done well, might very well take us--all of us--to important new places. Under the conception of community service and democratic education more generally, CSL projects in schools and universities can take us to "the" most important place: a…

  16. Comparaison of 85Kr measurements with the ADMS model (Atmospheric Dispersion Modelling System) on a coastal complex site

    NASA Astrophysics Data System (ADS)

    Leroy, C.; Maro, D.; Connan, O.; Hebert, D.; Rozet, M.

    2009-04-01

    Modelling atmospheric dispersion of radioactive plumes is a major issue for nuclear safety institutes to predict and estimate the radiological consequences to the population. The French Institute for the Radiological protection and the Nuclear Safety (IRSN) uses gaussian plume models, particularly adapted in accidental situations, because of short computation times. Due to the lack of experimental data, the reliability of these models is poorly documented and misunderstood for elevated sources in the near field and more particularly, in complex areas (topography, change of roughness). In order to improve the knowledge of dispersion mechanisms in such conditions, the IRSN ran a series of experimental campaigns between 1999 and 2002 in the vicinity of the La Hague nuclear reprocessing plant (AREVA NC - France). The La Hague peninsula is very narrow and the plant is located at 2 km from the coastline, at 150 m above sea level. During the experiments, the krypton-85 (85Kr), a radionucleide, was used as a non-reactive tracer of the plumes released by the 100 m high stack. In this work, the Atmospheric Transfer Coefficients (ATC) obtained from 85Kr measurements at La Hague are compared with the computations of the "next generation" gaussian model ADMS (Atmospheric Dispersion Modelling System) performed with "complex and coastal effects" ADMS modules.

  17. Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow.

    PubMed

    Li, Wei; Guo, Aili; Wang, Lijuan; Kong, Qingyu; Wang, Rong; Han, Li; Zhao, Cuifen

    2016-01-01

    Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive pulmonary arterial remodeling and right ventricular failure. Despite recent advances in pathophysiological mechanism exploration and new therapeutic approaches, PAH remains a challenging condition. In this study, we investigated the roles of the peptide fragments from proadrenomedullin (proADM) such as adrenomedullin (ADM), adrenotensin (ADT), and proadrenomedullin N-terminal 20 peptide (PAMP) during pulmonary remodeling caused by high pulmonary blood flow, and probed the possible involvement of mitogen-activated protein kinase (MAPK) signal transduction pathways. Sixteen rat models of PAH were artificially established by surgically connecting the left common carotid artery to the external jugular vein. We subcutaneously injected an extracellular signal-regulated protein kinase (ERK1/2) inhibitor, PD98059, in eight rats, treated another eight rats with an equal volume of saline. Eight rats without connections served as the control group. We observed that mRNA expression levels of ADM, stress-activated protein kinase (SAPK), and ERK1/2 were significantly elevated in the shunted rats; furthermore, ERK1/2 levels were significantly inhibited by PD98059. Protein levels of ADM, PAMP, p-SAPK, and p-ERK1/2 were significantly higher ADT was lower, and p-p38 remained unchanged in the rat models compared with the controls. However, the protein expression of both ADM and p-ERK1/2 was significantly inhibited by PD98059. Our results suggest that levels of ADM, ADT, and PAMP respond to pulmonary remodeling, and that activation of the SAPK and ERK1/2 signaling pathways is involved in pulmonary hypertension and artery remodeling caused by high pulmonary blood flow. PMID:25990643

  18. Evaluation and demonstration of decentralized space and water heating versus centralized services for new and rehabilitated multifamily buildings. Final report

    SciTech Connect

    Belkus, P.; Tuluca, A.

    1993-06-01

    The general objective of this research was aimed at developing sufficient technical and economic know-how to convince the building and design communities of the appropriateness and energy advantages of decentralized space and water heating for multifamily buildings. Two main goals were established to guide this research. First, the research sought to determine the cost-benefit advantages of decentralized space and water heating versus centralized systems for multifamily applications based on innovative gas piping and appliance technologies. The second goal was to ensure that this information is made available to the design community.

  19. Uncertainty characterization and quantification in air pollution models. Application to the ADMS-Urban model.

    NASA Astrophysics Data System (ADS)

    Debry, E.; Malherbe, L.; Schillinger, C.; Bessagnet, B.; Rouil, L.

    2009-04-01

    Evaluation of human exposure to atmospheric pollution usually requires the knowledge of pollutants concentrations in ambient air. In the framework of PAISA project, which studies the influence of socio-economical status on relationships between air pollution and short term health effects, the concentrations of gas and particle pollutants are computed over Strasbourg with the ADMS-Urban model. As for any modeling result, simulated concentrations come with uncertainties which have to be characterized and quantified. There are several sources of uncertainties related to input data and parameters, i.e. fields used to execute the model like meteorological fields, boundary conditions and emissions, related to the model formulation because of incomplete or inaccurate treatment of dynamical and chemical processes, and inherent to the stochastic behavior of atmosphere and human activities [1]. Our aim is here to assess the uncertainties of the simulated concentrations with respect to input data and model parameters. In this scope the first step consisted in bringing out the input data and model parameters that contribute most effectively to space and time variability of predicted concentrations. Concentrations of several pollutants were simulated for two months in winter 2004 and two months in summer 2004 over five areas of Strasbourg. The sensitivity analysis shows the dominating influence of boundary conditions and emissions. Among model parameters, the roughness and Monin-Obukhov lengths appear to have non neglectable local effects. Dry deposition is also an important dynamic process. The second step of the characterization and quantification of uncertainties consists in attributing a probability distribution to each input data and model parameter and in propagating the joint distribution of all data and parameters into the model so as to associate a probability distribution to the modeled concentrations. Several analytical and numerical methods exist to perform an

  20. A Safe Place to Stay Sharp: Action Learning Meets Cooperative Inquiry in the Service of NHS OD Capacity Building

    ERIC Educational Resources Information Center

    Traeger, James; Norgate, Carolyn

    2015-01-01

    This is an account of practice. It explores the meeting point between action learning and action research, as a way of doing capacity building in organisational development (OD) in the NHS in the UK. The authors were part of a short cooperative inquiry (Heron, J. 1996. "Co-operative Inquiry: Research into the Human Condition." London:…

  1. Protective Effect of Adrenomedullin on Rat Leydig Cells from Lipopolysaccharide-Induced Inflammation and Apoptosis via the PI3K/Akt Signaling Pathway ADM on Rat Leydig Cells from Inflammation and Apoptosis.

    PubMed

    Zhou, Pang-Hu; Hu, Wei; Zhang, Xiao-Bin; Wang, Wei; Zhang, Li-Jun

    2016-01-01

    This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, and COX-2 were obtained, and the concentrations of IL-1, IL-6, NO, and PGE2 were determined. Apoptosis was assessed by TUNEL and detection of DNA fragmentation. The levels of mRNA and protein were determined for Bcl-2, Bax, caspase-3, and PARP. The protein contents for total and p-Akt were measured. ADM pretreatment significantly elevated the MMP and testosterone concentration and reduced the levels of ROS, MDA, GSH, and LDH. ADM pretreatment significantly decreased the mRNA levels of IL-1, IL-6, iNOS, and COX-2 and the concentrations of IL-1, IL-6, NO, and PGE2. LPS-induced TUNEL-positive Leydig cells were significantly decreased by ADM pretreatment, a result further confirmed by decreased DNA fragmentation. ADM pretreatment decreased apoptosis by significantly promoting Bcl-2 and inhibiting Bax, caspase-3, and PARP expressions. The LPS activity that reduced p-Akt level was significantly inhibited by ADM pretreatment. ADM protected rat Leydig cells from LPS-induced inflammation and apoptosis, which might be associated with PI3K/Akt mitochondrial signaling pathway. PMID:27212810

  2. Protective Effect of Adrenomedullin on Rat Leydig Cells from Lipopolysaccharide-Induced Inflammation and Apoptosis via the PI3K/Akt Signaling Pathway ADM on Rat Leydig Cells from Inflammation and Apoptosis

    PubMed Central

    Zhou, Pang-Hu; Hu, Wei; Zhang, Xiao-Bin; Wang, Wei; Zhang, Li-Jun

    2016-01-01

    This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, and COX-2 were obtained, and the concentrations of IL-1, IL-6, NO, and PGE2 were determined. Apoptosis was assessed by TUNEL and detection of DNA fragmentation. The levels of mRNA and protein were determined for Bcl-2, Bax, caspase-3, and PARP. The protein contents for total and p-Akt were measured. ADM pretreatment significantly elevated the MMP and testosterone concentration and reduced the levels of ROS, MDA, GSH, and LDH. ADM pretreatment significantly decreased the mRNA levels of IL-1, IL-6, iNOS, and COX-2 and the concentrations of IL-1, IL-6, NO, and PGE2. LPS-induced TUNEL-positive Leydig cells were significantly decreased by ADM pretreatment, a result further confirmed by decreased DNA fragmentation. ADM pretreatment decreased apoptosis by significantly promoting Bcl-2 and inhibiting Bax, caspase-3, and PARP expressions. The LPS activity that reduced p-Akt level was significantly inhibited by ADM pretreatment. ADM protected rat Leydig cells from LPS-induced inflammation and apoptosis, which might be associated with PI3K/Akt mitochondrial signaling pathway. PMID:27212810

  3. Developing User-Driven Climate Information Services to Build Resilience Amongst Groups at Risk of Drought and Flood in Arid and Semi-Arid Land Counties in Kenya

    NASA Astrophysics Data System (ADS)

    Githungo, W. N.; Shaka, A.; Kniveton, D.; Muithya, L.; Powell, R.; Visman, E. L.

    2014-12-01

    The Arid and Semi-Arid Land (ASAL) counties of Kitui and Makueni in Kenya are experiencing increasing climate variability in seasonal rainfall, including changes in the onset, cessation and distribution of the two principal rains upon which the majority of the population's small-holder farmers and livestock keepers depend. Food insecurity is prevalent with significant numbers also affected by flooding during periods of intense rainfall. As part of a multi-partner Adaptation Consortium, Kenya Meteorological Services (KMS) are developing Climate Information Services (CIS) which can better support decision making amongst the counties' principal livelihoods groups and across County Government ministries. Building on earlier pilots and stakeholder discussion, the system combines the production of climate information tailored for transmission via regional and local radio stations with the establishment of a new SMS service. SMS are provided through a network of CIS intermediaries drawn from across key government ministries, religious networks, non-governmental and community groups, aiming to achieve one SMS recipient per 3-500 people. It also introduces a demand-led, premium-rate SMS weather information service which is designed to be self-financing in the long term. Supporting the ongoing process of devolution, KMS is downscaling national forecasts for each county, and providing seasonal, monthly, weekly and daily forecasts, as well as warnings of weather-related hazards. Through collaboration with relevant ministries, government bodies and research institutions, including livestock, agriculture, drought management and health, technical advisories are developed to provide guidance on application of the climate information. The system seeks to provide timely, relevant information which can enable people to use weather and climate information to support decisions which protect life and property and build resilience to ongoing climate variability and future change.

  4. Mental Health Services for the Elderly: Report on a Survey of Community Mental Health Centers. Volume III.

    ERIC Educational Resources Information Center

    Flemming, Arthur S.; And Others

    This is the third volume of a three-volume report on the Community Mental Health Center (CMHC) survey project undertaken to assess the impact of the Alcohol, Drug Abuse, and Mental Health Services (ADMS) block grant program on the delivery of mental health services to older persons. This volume presents results from a 2-year follow-up survey…

  5. R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments

    PubMed Central

    Vanquelef, Enguerran; Simon, Sabrina; Marquant, Gaelle; Garcia, Elodie; Klimerak, Geoffroy; Delepine, Jean Charles; Cieplak, Piotr; Dupradeau, François-Yves

    2011-01-01

    R.E.D. Server is a unique, open web service, designed to derive non-polarizable RESP and ESP charges and to build force field libraries for new molecules/molecular fragments. It provides to computational biologists the means to derive rigorously molecular electrostatic potential-based charges embedded in force field libraries that are ready to be used in force field development, charge validation and molecular dynamics simulations. R.E.D. Server interfaces quantum mechanics programs, the RESP program and the latest version of the R.E.D. tools. A two step approach has been developed. The first one consists of preparing P2N file(s) to rigorously define key elements such as atom names, topology and chemical equivalencing needed when building a force field library. Then, P2N files are used to derive RESP or ESP charges embedded in force field libraries in the Tripos mol2 format. In complex cases an entire set of force field libraries or force field topology database is generated. Other features developed in R.E.D. Server include help services, a demonstration, tutorials, frequently asked questions, Jmol-based tools useful to construct PDB input files and parse R.E.D. Server outputs as well as a graphical queuing system allowing any user to check the status of R.E.D. Server jobs. PMID:21609950

  6. R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments.

    PubMed

    Vanquelef, Enguerran; Simon, Sabrina; Marquant, Gaelle; Garcia, Elodie; Klimerak, Geoffroy; Delepine, Jean Charles; Cieplak, Piotr; Dupradeau, François-Yves

    2011-07-01

    R.E.D. Server is a unique, open web service, designed to derive non-polarizable RESP and ESP charges and to build force field libraries for new molecules/molecular fragments. It provides to computational biologists the means to derive rigorously molecular electrostatic potential-based charges embedded in force field libraries that are ready to be used in force field development, charge validation and molecular dynamics simulations. R.E.D. Server interfaces quantum mechanics programs, the RESP program and the latest version of the R.E.D. tools. A two step approach has been developed. The first one consists of preparing P2N file(s) to rigorously define key elements such as atom names, topology and chemical equivalencing needed when building a force field library. Then, P2N files are used to derive RESP or ESP charges embedded in force field libraries in the Tripos mol2 format. In complex cases an entire set of force field libraries or force field topology database is generated. Other features developed in R.E.D. Server include help services, a demonstration, tutorials, frequently asked questions, Jmol-based tools useful to construct PDB input files and parse R.E.D. Server outputs as well as a graphical queuing system allowing any user to check the status of R.E.D. Server jobs. PMID:21609950

  7. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance U.S. General Services Administration – Project 195 John Seiberling Federal Office Building and U.S. Courthouse, Akron, Ohio

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-05-28

    This report documents the findings from an onsite audit of the John Seiberling Federal building located in Akron, Ohio. The Federal landlord for this building is the General Services Administration (GSA). The focus of the audit was to identify various no-cost or low-cost energy efficiency opportunities that, once implemented, would reduce in either electrical and gas consumption and increase the operational efficiency of the building. This audit also provided an opportunity to identify potential capital cost projects that should be considered in the to acquire additional energy (electric and gas) and water savings to further increase the operational efficiency of the building.

  8. Absorption, Distribution, Metabolism and Excretion (ADME) Study with 2,2',4,4',5,6' Hexabromodiphenyl Ether(BDE 154)in Male Sprague-Dawley Rats

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Polybrominated diphenyl ethers(PBDEs)are among the most abundant brominated flame retardants in use in many consumer products. A particular subset of five PBDEs are known to be environmentally persistent, i.e. BDE-47, -99, -100, 153, and -154. Mammalian ADME studies have already been performed for...

  9. Using Multimedia Cases to Explore Pre-Service Teachers' Understanding of Community Building and Teaching for Equity and Inclusion

    ERIC Educational Resources Information Center

    Patel, Neelam

    2013-01-01

    The field of teacher education has long sought to examine the impact of coursework on teacher practice and student learning. Despite the promise of many forms of educational pedagogy and curricula utilized in teacher education programs, many novice teachers continue to feel unprepared and insecure about their teaching. Pre-service teacher…

  10. Building Coalitions To Provide HIV Legal Advocacy Services: Utilizing Existing Disability Models. AIDS Technical Report, No. 5.

    ERIC Educational Resources Information Center

    Harvey, David C.; Ardinger, Robert S.

    This technical report is part of a series on AIDS/HIV (Acquired Immune Deficiency Syndrome/Human Immunodeficiency Virus) and is intended to help link various legal advocacy organizations providing services to persons with mental illness or developmental disabilities. This report discusses strategies to utilize existing disability models for…

  11. Serving Hope: Building Service-Learning into a Non-Major Mathematics Course to Benefit the Local Community

    ERIC Educational Resources Information Center

    Schulteis, Melinda S.

    2013-01-01

    Service-learning has been shown to have benefits for both students and faculty, however, it is quite rare in the mathematics classroom. At Concordia University Irvine we have established a relationship with the Village of Hope--a local non-profit organization designed to help homeless families transition to a self-sufficient status via temporary…

  12. Adding an Extra Helping of Service when You Already Have a Full Plate: Building an Embedded Librarian Program

    ERIC Educational Resources Information Center

    Chesnut, Mary Todd; Wesley, Threasa L.; Zai, Robert, III

    2010-01-01

    The librarians at Northern Kentucky University's W. Frank Steely Library have successfully added a new embedded librarianship program to their established reference and instruction services, without the support of increased staffing. In fact, this program was established and has matured during a period of staff reductions. The decisions made in…

  13. Building the Service-Based Library Web Site: A Step-by-Step Guide to Design and Options.

    ERIC Educational Resources Information Center

    Garlock, Kristen L.; Piontek, Sherry

    The World Wide Web, with its captivating multimedia features and hypertext capabilities, has brought millions of new users to the Internet. Library staff who could create a home page on the Web could present basic information about the library and its services, showcase its resources, create links to quality material inside and outside the…

  14. Rehabilitation Training Program and Special Capacity Building Program, 1997-1998: Catalog of Projects under the Rehabilitation Services Administration.

    ERIC Educational Resources Information Center

    Office of Special Education and Rehabilitative Services (ED), Washington, DC.

    This directory lists programs funded by rehabilitation training grants funded under the Rehabilitation Act of 1973 (Section 304a). These programs are grouped under the following categories: (1) rehabilitation long-term training; (2) experimental and innovative training; (3) state vocational rehabilitation unit in-service training; (4)…

  15. Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

    PubMed Central

    2010-01-01

    As part of our effort to increase survival of drug candidates and to move our medicinal chemistry design to higher probability space for success in the Neuroscience therapeutic area, we embarked on a detailed study of the property space for a collection of central nervous system (CNS) molecules. We carried out a thorough analysis of properties for 119 marketed CNS drugs and a set of 108 Pfizer CNS candidates. In particular, we focused on understanding the relationships between physicochemical properties, in vitro ADME (absorption, distribution, metabolism, and elimination) attributes, primary pharmacology binding efficiencies, and in vitro safety data for these two sets of compounds. This scholarship provides guidance for the design of CNS molecules in a property space with increased probability of success and may lead to the identification of druglike candidates with favorable safety profiles that can successfully test hypotheses in the clinic. PMID:22778836

  16. A Comprehensive Insight into the Chemical Space and ADME Features of Small Molecule NS5A Inhibitors.

    PubMed

    Ivanenkov, Yan A; Veselov, Mark S; Shakhbazyan, Artem G; Aladinskiy, Vladimir A; Aladinskaya, Anastasia V; Yartseva, Sofya M; Majouga, Alexander G; Vantskul, Anton S; Leonov, Sergey V; Ivachtchenko, Alexandre V; Koteliansky, Victor E

    2016-01-01

    Non-structural 5A (NS5A) protein plays a crucial role in the replication of hepatitis C virus (HCV) and during the past decade has attracted increasing attention as a promising biological target for the treatment of viral infections and related disorders. Small-molecule NS5A inhibitors have shown significant antiviral activity in vitro and in vivo. Several lead molecules are reasonably regarded as novel highly potent drug candidates with favorable ADME features and tolerable side effects. The first-in-class daclatasvir has recently been launched into the market and 14 novel molecules are currently under evaluation in clinical trials. From this perspective, we provide an overview of the available chemical space of small-molecule NS5A inhibitors and their PK properties, mainly focusing on the diversity in structure and scaffold representation. PMID:26585933

  17. Reducing Demand through Efficiency and Services: Impacts and Opportunities in Buildings Sector (Carbon Cycle 2.0)

    SciTech Connect

    Piette, Mary Ann

    2010-02-02

    Mary Ann Piette, Deputy of LBNL's Building Technologies Department and Director of the Demand Response Research Center, speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 2, 2010. We emit more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences. Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  18. Reducing Demand through Efficiency and Services: Impacts and Opportunities in Buildings Sector (Carbon Cycle 2.0)

    ScienceCinema

    Piette, Mary Ann [Director, Demand Response Research Center

    2011-06-08

    Mary Ann Piette, Deputy of LBNL's Building Technologies Department and Director of the Demand Response Research Center, speaks at the Carbon Cycle 2.0 kick-off symposium Feb. 2, 2010. We emit more carbon into the atmosphere than natural processes are able to remove - an imbalance with negative consequences. Carbon Cycle 2.0 is a Berkeley Lab initiative to provide the science needed to restore this balance by integrating the Labs diverse research activities and delivering creative solutions toward a carbon-neutral energy future. http://carboncycle2.lbl.gov/

  19. [Cloning and function identification of gene 'admA' and up-stream regulatory sequence related to antagonistic activity of Enterobacter cloacae B8].

    PubMed

    Zhu, Jun-Li; Li, De-Bao; Yu, Xu-Ping

    2012-04-01

    To reveal the antagonistic mechanism of B8 strain to Xanthomonas oryzae pv. oryzae, transposon tagging method and chromosome walking were deployed to clone antagonistic related fragments around Tn5 insertion site in the mutant strain B8B. The function of up-stream regulatory sequence of gene 'admA' involved in the antagonistic activity was further identified by gene knocking out technique. An antagonistic related left fragment of Tn5 insertion site, 2 608 bp in length, was obtained by tagging with Kan resistance gene of Tn5. A 2 354 bp right fragment of Tn5 insertion site was amplified with 2 rounds of chromosome walking. The length of the B contig around the Tn5 insertion site was 4 611 bp, containing 7 open reading frames (ORFs). Bioinformatic analysis revealed that these ORFs corresponded to the partial coding regions of glyceraldehyde-3-phosphate dehydrogenase, two LysR family transcriptional regulators, hypothetical protein VSWAT3-20465 of Vibrionales and admA, admB, and partial sequence of admC gene of Pantoea agglomerans biosynthetic gene cluster, respectively. Tn5 was inserted in the up-stream of 200 bp or 894 bp of the sequence corresponding to anrP ORF or admA gene on B8B, respectively. The B-1 and B-2 mutants that lost antagonistic activity were selected by homeologuous recombination technology in association with knocking out plasmid pMB-BG. These results suggested that the transcription and expression of anrP gene might be disrupted as a result of the knocking out of up-stream regulatory sequence by Tn5 in B8B strain, further causing biosythesis regulation of the antagonistic related gene cluster. Thus, the antagonistic related genes in B8 strain is a gene family similar as andrimid biosynthetic gene cluster, and the upstream regulatory region appears to be critical for the antibiotics biosynthesis. PMID:22522167

  20. Investing in HIV services while building Kenya's health system: PEPFAR's support to prevent mother-to-child HIV transmission.

    PubMed

    Dutta, Arin; Wallace, Nathan; Savosnick, Peter; Adungosi, John; Kioko, Urbanus Mutuku; Stewart, Scott; Hijazi, Mai; Gichanga, Bedan

    2012-07-01

    Trade-offs may exist between investments to promote health system strengthening, such as investments in facilities and training, and the rapid scale-up of HIV/AIDS services. We analyzed trends in expenditures to support the prevention of mother-to-child transmission of HIV in Kenya under the President's Emergency Plan for AIDS Relief (PEPFAR) from 2005 to 2010. We examined how expenditures changed over time, considering health system strengthening alongside direct treatment of patients. We focused on two organizations carrying out contracts under PEPFAR: the Elizabeth Glaser Pediatric AIDS Foundation and FHI360 (formerly Family Health International), a nonprofit health and development organization. We found that the average unit expenditure, or the spending on goods and services per mother living with HIV who was provided with antiretroviral drugs, declined by 52 percent, from $567 to $271, during this time period. The unit expenditure per mother-to-infant transmission averted declined by 66 percent, from $7,117 to $2,440. Meanwhile, the health system strengthening proportion of unit expenditure increased from 12 percent to 33 percent during the same time period. The analysis suggests that PEPFAR investments in prevention of mother-to-child transmission of HIV in Kenya became more efficient over time, and that there was no strong evidence of a trade-off between scaling up services and investing in health systems. PMID:22778339

  1. Using a meta-model to build a connection service in an object oriented medical application development environment.

    PubMed Central

    Jean, F. C.; Mascart, J. J.; Codaccioni, A.; Lavril, M.; Sauquet, D.; Degoulet, P.

    1994-01-01

    Interoperability is a key issue in distributed health information systems. This paper presents the design and implementation of the Connection Service (CS) component of the HELIOS medical software engineering environment. An exchange message meta-model based on CEN TC251 recommendations and a message description language are proposed. Using this meta-model, the CS is able either to interpret messages expressed in a given syntax (e.g., EDIFACT, ASTM) and map them to the application objects or to automate the translation of the messages in another syntax. It is concluded that this meta-model approach contributes to the management of semantic heterogeneity. PMID:7949974

  2. Peace-building and reconciliation dividends of integrated health services delivery in post-conflict Burundi: qualitative assessments of providers and community members.

    PubMed

    Christensen, Cathryn; Edward, Anbrasi

    2015-01-01

    While demonstrating causality remains challenging, several 'health-peace' mechanisms have been proposed to describe how health systems contribute to peace-building and stability in post-conflict settings. A qualitative study was undertaken in southern Burundi to identify drivers of social tension and reconciliation in the catchment area of Village Health Works, a health services organisation. Key informant interviews and focus group discussions were conducted in early 2014 with a total of one hundred and twenty community members and staff representing a range of conflict and recovery experience. Themes emerging from these interviews indicated mechanisms at the individual, household, community, and regional levels through which health provision mitigates tensions and promotes social cohesion. This peace dividend was amplified by the clinic's integrated model, which facilitates further community interaction through economic, agricultural and education programmes. Land pressure and the marginalisation of repatriated refugees were cited as drivers of local tension. PMID:25875719

  3. The Unified Access Framework (UAF) guide to building an interoperable gridded data service in about 15 minutes

    NASA Astrophysics Data System (ADS)

    O'Brien, K.; Austin, M.; Casey, K. S.; de la Beaujardiere, J.; Habermann, T.; Hankin, S. C.; Koyuk, H.; McCulloch, L.; Mendelssohn, R.; Rutledge, G. K.; Signell, R. P.

    2011-12-01

    Insufficiently integrated data management and access systems are a major problem that data managers, scientists and users encounter when trying to serve, locate or use climate data. A fragmented approach to data management has promoted individualized solutions, often resulting in the creation of non-interoperable data formats and protocols. The NOAA-led Unified Access Framework (UAF) project has endeavored to define a framework for data providers wishing to share their data in a more interoperable manner. Using standards and conventions that are already widely used and embraced by the community, such interoperable data solutions can be quickly and easily configured and made available to the public. Though gazing through this optimistic interoperability lens, we do realize that there are still limitations within the data community that must be faced. In fact, the solutions that we plan to demonstrate are only really mature for gridded datasets. As well, there are many outstanding issues dealing with immature metadata (including lack of detailed model configurations and data provenance information) which must be overcome for true interoperability. In this presentation, however, we will be demonstrating that, by embracing open standards and conventions and community supported resources, it is possible to have an interoperable data service for gridded data up and running in less than 15 minutes. Following the storyline of a modeler who has data s/he wants to share immediately, we'll demonstrate how to serve the data using OPeNDAP and THREDDS. We'll also exhibit how to easily improve the data in order to increase interoperability, without modification to the original dataset. These improvements will include techniques for data aggregation and also methods to ensure compliance with known conventions, such as the Climate and Forecast (CF) metadata conventions. The presentation will culminate with a discussion and demonstration of a few of the many available and widely

  4. Buildings interoperability landscape - Draft

    SciTech Connect

    Hardin, Dave B.; Stephan, Eric G.; Wang, Weimin; Corbin, Charles D.; Widergren, Steven E.

    2015-02-01

    Buildings are an integral part of our nation’s energy economy. The advancement in information and communications technology (ICT) has revolutionized energy management in industrial facilities and large commercial buildings. As ICT costs decrease and capabilities increase, buildings automation and energy management features are transforming the small-medium commercial and residential buildings sectors. A vision of a connected world in which equipment and systems within buildings coordinate with each other to efficiently meet their owners’ and occupants’ needs, and where buildings regularly transact business with other buildings and service providers (such as gas and electric service providers) is emerging. However, while the technology to support this collaboration has been demonstrated at various degrees of maturity, the integration frameworks and ecosystems of products that support the ability to easily install, maintain, and evolve building systems and their equipment components are struggling to nurture the fledging business propositions of their proponents.

  5. Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo.

    PubMed

    Slatter, J G; Cheng, O; Cornwell, P D; de Souza, A; Rockett, J; Rushmore, T; Hartley, D; Evers, R; He, Y; Dai, X; Hu, R; Caguyong, M; Roberts, C J; Castle, J; Ulrich, R G

    2006-01-01

    To examine species-specific aspects of the induction of absorption, distribution, metabolism and excretion (ADME)-related genes, we used 25 000 gene oligonucleotide microarrays to construct a rodent gene-response compendium that compared hepatic gene expression profiles and developed consensus aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR) and pregnane X-receptor (PXR) ligand signatures relevant to drug clearance. Twenty-six inducer compounds were chosen from the literature. Rats and mice received one of six dose levels (log2 dose escalation, 32-fold dose range) of each compound daily for 3 days. Animals were necropsied 6-9 h after the last dose, and tissues were collected for RNA analysis. Hepatic gene expression profiles were obtained using Rosetta Resolver expression analysis system, and ADME-related genes were extracted. Cross-talk among nuclear receptors or hepatoxicity at high dose levels resulted in large signatures (usually >1000 genes at p < 0.01) for most compounds. After ADME gene transcript enrichment, agglomerative clustering separated AhR ligands from CAR/PXR ligands, but it was difficult to distinguish CAR from PXR ligands. Consensus signatures were derived from groups of AhR, CAR and PXR ligands; and cross-talk among responding genes was determined. Many compounds had distinct log dose-response profiles, and relative potencies for ligands were established. Robust responses by CYP1A1, CYP2B10 (CAR responsive in mice) and CYP2B15 (CAR responsive in rats) and CYP3A1 (PXR responsive in rats) were used to benchmark the relative potency of different ligands and to determine the relative selectivity for AhR, CAR or PXR. By using a compendium of gene expression profiles, we defined species-specific induction patterns across the ADME transcriptome. PMID:17118914

  6. Implementation of the IWA anaerobic digestion model No.1 (ADM1) for simulating digestion of blackwater from vacuum toilets.

    PubMed

    Feng, Y; Behrendt, J; Wendland, C; Otterpohl, R

    2006-01-01

    The IWA anaerobic digestion model No.1 (ADM1) is applied to the blackwater anaerobic digestion (BWAD) plant in this work. In order to verify the biochemical kinetics, batch experiments were executed. According to the Monod type kinetics, the maximum uptake rates (km) of butyric acid (HBu), propionic acid (HPr) and acetic acid (HAc) are testified as 18, 14, 13 d(-1), and their half saturation concentrations (Ks) are 110, 120, 160 g COD/m3, respectively. Afterwards, the model was calibrated based on the performance of a laboratory scale BWAD plant (under mesophilic conditions) by three scenario studies, i.e. the reference conditions, different feeding frequencies and high NH4+ concentration. The model successfully simulated three scenarios. The further two virtual scenario studies were achieved based on the calibrated model. First, the performance of BWAD plant was predicted with different hydraulic retention times (HRT); second, the kitchen refuse (KR) was added into the BWAD plant as additional organic loading. The model predicted the perspective of BW plus KR digestion and generated valuable suggestions for the operation of the real BWAD plant. PMID:16841750

  7. Pharmacophore Identification, Molecular Docking, Virtual Screening, and In Silico ADME Studies of Non-Nucleoside Reverse Transcriptase Inhibitors.

    PubMed

    Pirhadi, Somayeh; Ghasemi, Jahan B

    2012-12-01

    Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive place due to their unique antiviral potency, high specificity and low toxicity in antiretroviral combination therapies used to treat HIV. In this study, chemical feature based pharmacophore models of different classes of NNRT inhibitors of HIV-1 have been developed. The best HypoRefine pharmacophore model, Hypo 1, which has the best correlation coefficient (0.95) and the lowest RMS (0.97), contains two hydrogen bond acceptors, one hydrophobic and one ring aromatic feature, as well as four excluded volumes. Hypo 1 was further validated by test set and Fischer validation method. The best pharmacophore model was then utilized as a 3D search query to perform a virtual screening to retrieve potential inhibitors. The hit compounds were subsequently subjected to filtering by Lipinski's rule of five and docking studies by Libdock and Gold methods to refine the retrieved hits. Finally, 7 top ranked compounds based on Gold score fitness function were subjected to in silico ADME studies to investigate for compliance with the standard ranges. PMID:27476739

  8. Modelling of two-stage anaerobic digestion using the IWA Anaerobic Digestion Model No. 1 (ADM1).

    PubMed

    Blumensaat, F; Keller, J

    2005-01-01

    The aim of the study presented was to implement a process model to simulate the dynamic behaviour of a pilot-scale process for anaerobic two-stage digestion of sewage sludge. The model implemented was initiated to support experimental investigations of the anaerobic two-stage digestion process. The model concept implemented in the simulation software package MATLAB/Simulink is a derivative of the IWA Anaerobic Digestion Model No.1 (ADM1) that has been developed by the IWA task group for mathematical modelling of anaerobic processes. In the present study the original model concept has been adapted and applied to replicate a two-stage digestion process. Testing procedures, including balance checks and 'benchmarking' tests were carried out to verify the accuracy of the implementation. These combined measures ensured a faultless model implementation without numerical inconsistencies. Parameters for both, the thermophilic and the mesophilic process stage, have been estimated successfully using data from lab-scale experiments described in literature. Due to the high number of parameters in the structured model, it was necessary to develop a customised procedure that limited the range of parameters to be estimated. The accuracy of the optimised parameter sets has been assessed against experimental data from pilot-scale experiments. Under these conditions, the model predicted reasonably well the dynamic behaviour of a two-stage digestion process in pilot scale. PMID:15607176

  9. Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1.

    PubMed

    Yi, Ying-Jie; Jia, Xiu-Hong; Wang, Jian-Yong; Li, You-Jie; Wang, Hong; Xie, Shu-Yang

    2016-05-01

    Multidrug resistance (MDR) of leukemia cells is a major obstacle in chemotherapeutic treatment. The high expression and constitutive activation of P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP-1) have been reported to play a vital role in enhancing cell resistance to anticancer drugs in many tumors. The present study aimed to investigate the reversal of MDR by silencing homeobox A10 (HOXA10) in adriamycin (ADR)-resistant human chronic myelogenous leukemia (CML) K562/ADM cells by modulating the expression of P-gp and MRP-1. K562/ADM cells were stably transfected with HOXA10-targeted short hairpin RNA (shRNA). The results of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis showed that the mRNA and protein expression of HOXA10 was markedly suppressed following transfection with a shRNA-containing vector. The sensitivity of the K562/ADM cells to ADR was enhanced by the silencing of HOXA10, due to the increased intracellular accumulation of ADR. The accumulation of ADR induced by the silencing of HOXA10 may be due to the downregulation of P-gp and MRP-1. Western blot analysis revealed that downregulating HOXA10 inhibited the protein expression of P-gp and MRP-1. Taken together, these results suggest that knockdown of HOXA10 combats resistance and that HOXA10 is a potential target for resistant human CML. PMID:27035504

  10. shRNA-mediated silencing of sorcin increases drug chemosensitivity in myeloma KM3/DDP and U266/ADM cell lines.

    PubMed

    Xu, Ping; Jiang, Yong-Fang; Wang, Jing-Hua

    2015-01-01

    Sorcin is a penta-EF hand calcium binding protein, which is involved in the resistance to chemotherapeutics in cancer cells, and is overexpressed in various cancer cells. However, tumor relapse combined with the development of drug resistance remains a significant problem. Here, we demonstrated that silencing of Sorcin in chemotherapy resistance myeloma U266/ADM and KM3/DDP cell lines resulted in reduced cell proliferation, cell cycle arrest and cell apoptosis. Sorcin siRNA successfully silenced Sorcin mRNA and protein expression. Silencing of Sorcin also significantly reduced the mRNA and protein expression levels of MDR1, MRP1, GST-π, Survinvin, Livin, Bcl-2, Cyclin-D1, phospho-Src, C-myc, p21, NF-κB and phospho-AKT, while p53 expression and caspase-3 and caspase-8 activity significantly increased when compared with control group. Silencing of Sorcin significantly increased the sensitivity of KM3/DDP cells to cisplatin and the sensitivity of U266/ADM to adriamycin, compared to cells untransfected and transfected with negative control shRNA. In addition, intracellular accumulation of Rhodamine 123 significantly increased in KM3/DDP and U266/ADM cells. In summary, our studies indicate that drug resistance can be effectively reversed in cisplatin-resistance and adriamycin-resistant myeloma cells through delivery of siRNAs targeting Sorcin. Assessment of potential as a target for human myeloma treatment is clearly warranted. PMID:26045737

  11. Building the Child Wellbeing Project: Practitioners' Perspectives on the Role of Implementation Science in Strengthening Post-Care Child Welfare Services. Research-to-Results Brief. Publication #2012-18

    ERIC Educational Resources Information Center

    Wilson, Dawn; Brandes, Beth; Ball, Heather; Malm, Karin

    2012-01-01

    This is the third brief in a series: "Building a Post-Care Service System in Child Welfare: Lessons Learned from the Frontlines of Implementation Science in Catawba County." The first of the three briefs provided background information on the initiative that is the focus of the series--the Catawba County Child Wellbeing Project. Both Brief 2 and…

  12. Antileishmanial activity of novel indolyl-coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction.

    PubMed

    Sangshetti, Jaiprakash N; Khan, Firoz A Kalam; Kulkarni, Abhishek A; Patil, Rajendra H; Pachpinde, Amol M; Lohar, Kishan S; Shinde, Devanand B

    2016-02-01

    In present work we have designed and synthesized total twelve novel 3-(3-(1H-indol-3-yl)-3-phenylpropanoyl)-4-hydroxy-2H-chromen-2-one derivatives 13(a-l) using Ho(3+) doped CoFe2O4 nanoparticles as catalyst and evaluated for their potential antileishmanial and antioxidant activities. The compounds 13a, 13d and 13h were found to possess significant antileishmanial activity (IC50 value=95.50, 95.00 and 99.00μg/mL, respectively) when compared to the standard sodium stibogluconate (IC50=490.00 μg/mL). The compounds 13a (IC50=12.40 μg/mL), 13d (IC50=13.49 μg/mL), 13g (IC50=13.24 μg/mL) and 13l (IC50=13.74 μg/mL) had shown good antioxidant activity when compared with standards butylated hydroxy toluene (IC50=16.5 μg/mL) and ascorbic acid (IC50=12.8 μg/mL). After performing molecular docking studies, it was found that compounds 13a and 13d had potential to inhibit pteridine reductase 1 enzyme. In silico ADME pharmacokinetic parameters had shown promising results and none of the synthesized compounds had violated Lipinski's rule of five. Thus, suggesting that compounds from the present series can serve as important gateway for the design and development of new antileishmanial as well as antioxidant agent. PMID:26778149

  13. Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes

    SciTech Connect

    Elferink, M.G.L.; Olinga, P.; van Leeuwen, E.M.; Bauerschmidt, S.; Polman, J.; Schoonen, W.G.; Heisterkamp, S.H.; Groothuis, G.M.M.

    2011-05-15

    In the process of drug development it is of high importance to test the safety of new drugs with predictive value for human toxicity. A promising approach of toxicity testing is based on shifts in gene expression profiling of the liver. Toxicity screening based on animal liver cells cannot be directly extrapolated to humans due to species differences. The aim of this study was to evaluate precision-cut human liver slices as in vitro method for the prediction of human specific toxicity by toxicogenomics. The liver slices contain all cell types of the liver in their natural architecture. This is important since drug-induced toxicity often is a multi-cellular process. Previously we showed that toxicogenomic analysis of rat liver slices is highly predictive for rat in vivo toxicity. In this study we investigated the levels of gene expression during incubation up to 24 h with Affymetrix microarray technology. The analysis was focused on a broad spectrum of genes related to stress and toxicity, and on genes encoding for phase-I, -II and -III metabolizing enzymes and transporters. Observed changes in gene expression were associated with cytoskeleton remodeling, extracellular matrix and cell adhesion, but for the ADME-Tox related genes only minor changes were observed. PCA analysis showed that changes in gene expression were not associated with age, sex or source of the human livers. Slices treated with acetaminophen showed patterns of gene expression related to its toxicity. These results indicate that precision-cut human liver slices are relatively stable during 24 h of incubation and represent a valuable model for human in vitro hepatotoxicity testing despite the human inter-individual variability.

  14. Building Specifications

    NASA Technical Reports Server (NTRS)

    1978-01-01

    building shows that, while MASTERSPEC saves time and money, its use involves no sacrfice in architectural design freedom. The Naval Engineering Facilities Command employs an automated specifications system based on SPECSINTACT. The Public Buildings Service of the General Services Administration used SPECSINTACT as a starting point in a plan to make its guideline specifications available to architects and engineers on a nationwide computer network. Public Technology, Inc., a NASA Technology Application Team, is working with Production Systems for Architects and Engineers, Inc., to promote widespread use of the system by state and local governments for cost benefits to taxpayers.

  15. The Solaar HIV prevention program for gay and bisexual Latino men: using social marketing to build capacity for service provision and evaluation.

    PubMed

    Conner, Ross F; Takahashi, Lois; Ortiz, Eloy; Archuleta, Eduardo; Muniz, Juan; Rodriguez, Julio

    2005-08-01

    Community-researcher partnerships can be powerful mechanisms to understand and effectively address health and social problems such as HIV/AIDS prevention. When the partnership is a positive, productive one, the combined expertise and energy of both parties result in a more effective program and a better evaluation of its effects. This article describes one such partnership and how a program challenge provided the opportunity for both partners to develop new capacities and strengthen others. The program is Proyecto SOLAAR, a community-based and culturally-sensitive HIV prevention program for gay and bisexual Latino men. The program is an experiential, daylong retreat focused on personal aspects of the men (e.g., self-concept), ideas about and aspects of their relationship behavior (e.g., cultural misunderstandings, dating behavior), and HIV prevention; there is a follow-up reunion a month later to share experiences with other participants about new dating and HIV prevention behaviors. The article focuses in particular on how the partners built new capacity in the area of social marketing to address the challenge of participant recruitment and describes the components of the new campaign. These components included distinctive images in ads in publications read by the target population, a toll-free telephone number and Web site for easy initial contact with the program, phone cards and postcards featuring the specially created program image to reinforce a connection to the program, and other aspects. The article describes the partnership between the HIV service providers and the researchers and how the collaborative effort was key to understanding and addressing the recruitment problem, identifying potential solutions, and implementing the new social marketing strategy. This process resulted in four kinds of capacities that were built or strengthened, including program recruitment, program content and implementation, program evaluation, and the partnership itself. The

  16. Dose-Independent ADME Properties and Tentative Identification of Metabolites of α-Mangostin from Garcinia mangostana in Mice by Automated Microsampling and UPLC-MS/MS Methods

    PubMed Central

    Kim, Yu Chul; Chin, Young-Won; Choi, Young Hee

    2015-01-01

    The information about a marker compound's pharmacokinetics in herbal products including the characteristics of absorption, distribution, metabolism, excretion (ADME) is closely related to the efficacy/toxicity. Also dose range and administration route are critical factors to determine the ADME profiles. Since the supply of a sufficient amount of a marker compound in in vivo study is still difficult, pharmacokinetic investigations which overcome the limit of blood collection in mice are desirable. Thus, we have attempted to investigate concurrently the ADME and proposed metabolite identification of α-mangostin, a major constituent of mangosteen, Garcinia mangostana L, in mice with a wide dose range using an in vitro as well as in vivo automated micro-sampling system together. α-mangostin showed dose-proportional pharmacokinetics at intravenous doses of 5–20 mg/kg and oral doses of 10–100 mg/kg. The gastrointestinal absorption of α-mangostin was poor and the distribution of α-mangostin was relatively high in the liver, intestine, kidney, fat, and lung. α-mangostin was extensively metabolized in the liver and intestine. With regards to the formation of metabolites, the glucuronidated, bis-glucuronidated, dehydrogenated, hydrogenated, oxidized, and methylated α-mangostins were tentatively identified. We suggest that these dose-independent pharmacokinetic characteristics of α-mangostin in mice provide an important basis for preclinical applications of α-mangostin as well as mangosteen. In addition, these experimental methods can be applied to evaluate the pharmacokinetics of natural products in mice. PMID:26176540

  17. Dose-Independent ADME Properties and Tentative Identification of Metabolites of α-Mangostin from Garcinia mangostana in Mice by Automated Microsampling and UPLC-MS/MS Methods.

    PubMed

    Han, Seung Yon; You, Byoung Hoon; Kim, Yu Chul; Chin, Young-Won; Choi, Young Hee

    2015-01-01

    The information about a marker compound's pharmacokinetics in herbal products including the characteristics of absorption, distribution, metabolism, excretion (ADME) is closely related to the efficacy/toxicity. Also dose range and administration route are critical factors to determine the ADME profiles. Since the supply of a sufficient amount of a marker compound in in vivo study is still difficult, pharmacokinetic investigations which overcome the limit of blood collection in mice are desirable. Thus, we have attempted to investigate concurrently the ADME and proposed metabolite identification of α-mangostin, a major constituent of mangosteen, Garcinia mangostana L, in mice with a wide dose range using an in vitro as well as in vivo automated micro-sampling system together. α-mangostin showed dose-proportional pharmacokinetics at intravenous doses of 5-20 mg/kg and oral doses of 10-100 mg/kg. The gastrointestinal absorption of α-mangostin was poor and the distribution of α-mangostin was relatively high in the liver, intestine, kidney, fat, and lung. α-mangostin was extensively metabolized in the liver and intestine. With regards to the formation of metabolites, the glucuronidated, bis-glucuronidated, dehydrogenated, hydrogenated, oxidized, and methylated α-mangostins were tentatively identified. We suggest that these dose-independent pharmacokinetic characteristics of α-mangostin in mice provide an important basis for preclinical applications of α-mangostin as well as mangosteen. In addition, these experimental methods can be applied to evaluate the pharmacokinetics of natural products in mice. PMID:26176540

  18. Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline.

    PubMed

    Manda, Vamshi K; Avula, Bharathi; Ali, Zulfiqar; Khan, Ikhlas A; Walker, Larry A; Khan, Shabana I

    2014-05-01

    Mitragyna speciosa (kratom) is a popular herb in Southeast Asia, which is traditionally used to treat withdrawal symptoms associated with opiate addiction. Mitragynine, 7-hydroxymitragynine, and mitraphylline are reported to be the central nervous system active alkaloids which bind to the opiate receptors. Mitraphylline is also present in the bark of Uncaria tomentosa (cat's claw). Several therapeutic properties have been reported for these compounds but limited information is available on the absorption and distribution properties. This study focuses on evaluating the absorption, distribution, metabolism, and excretion (ADME) properties of these compounds and their effect on major efflux transporter P-glycoprotein, using in vitro methods. Quantitative analysis was performed by the Q-TOF LC-MS system. Mitragynine was unstable in simulated gastric fluid with 26 % degradation but stable in simulated intestinal fluid. 7-Hydroxymitragynine degraded up to 27 % in simulated gastric fluid, which could account for its conversion to mitragynine (23 %), while only 6 % degradation was seen in simulated intestinal fluid. Mitraphylline was stable in simulated gastric fluid but unstable in simulated intestinal fluid (13.6 % degradation). Mitragynine and 7-hydroxymitragynine showed moderate permeability across Caco-2 and MDR-MDCK monolayers with no significant efflux. However, mitraphylline was subjected to efflux mediated by P-glycoprotein in both Caco-2 and MDR-MDCK monolayers. Mitragynine was found to be metabolically stable in both human liver microsomes and S9 fractions. In contrast, both 7-hydroxymitragynine and mitraphylline were metabolized by human liver microsomes with half-lives of 24 and 50 min, respectively. All three compounds exhibited high plasma protein binding (> 90 %) determined by equilibrium dialysis. Mitragynine and 7-hydroxymitragynine inhibited P-glycoprotein with EC50 values of 18.2 ± 3.6 µM and 32.4 ± 1.9 µM, respectively

  19. 76 FR 6792 - Federal Management Regulation; FMR Bulletin PBS-2011-B1; Redesignations of Federal Buildings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ... AGENCY: Public Buildings Service (P), General Services Administration. ACTION: Notice of a bulletin... Services Administration, Public Buildings Service (P), Attn: David E. Foley, 1800 F Street, NW., Washington... Federal buildings? U.S. General Services Administration, Public Buildings Service (P), Attn: David...

  20. VIEW OF BUILDING 112 UNDER CONSTRUCTION, LOOKING NORTH, NORTHWEST. BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF BUILDING 112 UNDER CONSTRUCTION, LOOKING NORTH, NORTHWEST. BUILDING 112, ONE OF THE FIRST TEN PERMANENT BUILDINGS CONSTRUCTED AT THE ROCKY FLATS PLANT, PROVIDED THE FIRST CAFETERIA SERVICES ON SITE. (6/52) - Rocky Flats Plant, General Cafeteria, Main entrance on Highway 93, Golden, Jefferson County, CO

  1. VIEW LOOKING SOUTHWEST AT BUILDING 122 DURING CONSTRUCTION. BUILDING 122, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW LOOKING SOUTHWEST AT BUILDING 122 DURING CONSTRUCTION. BUILDING 122, THE EMERGENCY MEDICAL BUILDING, WAS ONE OF THE ORIGINAL STRUCTURES AT THE ROCKY FLATS PLANT. (5/29/52) - Rocky Flats Plant, Emergency Medical Services Facility, Southwest corner of Central & Third Avenues, Golden, Jefferson County, CO

  2. Building thermography and energy performance directive of buildings

    NASA Astrophysics Data System (ADS)

    Kauppinen, Timo; Siikanen, Sami

    2012-06-01

    Energy Performance of Buildings Directive came in to the force in Europe couple of years ago and it had an immediate effect on Building Codes in Europe. Finland have changed its building codes since 2007 - the insulation requirements have been tightened and the requirements have been specified. The biggest change is energy efficient calculations and determination of energy efficiency and energy label for buildings. This has caused a boom of new service providers (thermography services, air-tightness measurements and other services like new calculation tools). Thermography is used in verification in performance of buildings. In this presentation some examples of building thermography in walk-through energy audits combined with the results of energy efficiency calculations are presented - also some special problems in buildings of specific use (e.g. an art museum) and use of thermography to solve them.

  3. 77 FR 35393 - Federal Management Regulation; FMR Bulletin PBS-2012-03; Redesignations of Federal Buildings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... ADMINISTRATION Federal Management Regulation; FMR Bulletin PBS-2012-03; Redesignations of Federal Buildings AGENCY: Public Buildings Service (PBS), General Services Administration (GSA). ACTION: Notice of a... buildings. Expiration Date: This bulletin announcement expires October 31, 2012. The building...

  4. Predicting the Weather and Building the Boats: Full Service Schools as One Avenue to School Success for All of America's Children

    ERIC Educational Resources Information Center

    Kronick, Robert F.

    2003-01-01

    This article describes the evolution of full service schools. Full service schools stress prevention, collaboration and systems change. Prevention is geared toward corrections, mental health and welfare, all topics of keen interest to people working in and studying criminal justice. By providing mental health services at the school for both…

  5. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

    PubMed

    Wang, Xiaofang; Dong, Yuxiang; Wittlin, Sergio; Charman, Susan A; Chiu, Francis C K; Chollet, Jacques; Katneni, Kasiram; Mannila, Janne; Morizzi, Julia; Ryan, Eileen; Scheurer, Christian; Steuten, Jessica; Santo Tomas, Josefina; Snyder, Christopher; Vennerstrom, Jonathan L

    2013-03-28

    To ascertain the structure-activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439, we compared the antimalarial activities and ADME profiles of the 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. Consistent with previous data, both dioxolanes had very weak antimalarial properties. For the OZ277 series, the trioxane isostere had the best ADME profile, but its overall antimalarial efficacy was not superior to that of the trioxolane or tetraoxane isosteres. For the OZ439 series, there was a good correlation between the antimalarial efficacy and ADME profiles in the rank order trioxolane > trioxane > tetraoxane. As we have previously observed for OZ439 versus OZ277, the OZ439 series peroxides had superior exposure and efficacy in mice compared to the corresponding OZ277 series peroxides. PMID:23489135

  6. Equivalence of ADM Hamiltonian and Effective Field Theory approaches at next-to-next-to-leading order spin1-spin2 coupling of binary inspirals

    SciTech Connect

    Levi, Michele; Steinhoff, Jan E-mail: jan.steinhoff@ist.utl.pt

    2014-12-01

    The next-to-next-to-leading order spin1-spin2 potential for an inspiralling binary, that is essential for accuracy to fourth post-Newtonian order, if both components in the binary are spinning rapidly, has been recently derived independently via the ADM Hamiltonian and the Effective Field Theory approaches, using different gauges and variables. Here we show the complete physical equivalence of the two results, thereby we first prove the equivalence of the ADM Hamiltonian and the Effective Field Theory approaches at next-to-next-to-leading order with the inclusion of spins. The main difficulty in the spinning sectors, which also prescribes the manner in which the comparison of the two results is tackled here, is the existence of redundant unphysical spin degrees of freedom, associated with the spin gauge choice of a point within the extended spinning object for its representative worldline. After gauge fixing and eliminating the unphysical degrees of freedom of the spin and its conjugate at the level of the action, we arrive at curved spacetime generalizations of the Newton-Wigner variables in closed form, which can also be used to obtain further Hamiltonians, based on an Effective Field Theory formulation and computation. Finally, we make use of our validated result to provide gauge invariant relations among the binding energy, angular momentum, and orbital frequency of an inspiralling binary with generic compact spinning components to fourth post-Newtonian order, including all known sectors up to date.

  7. The statistical evaluation and comparison of ADMS-Urban model for the prediction of nitrogen dioxide with air quality monitoring network.

    PubMed

    Dėdelė, Audrius; Miškinytė, Auksė

    2015-09-01

    In many countries, road traffic is one of the main sources of air pollution associated with adverse effects on human health and environment. Nitrogen dioxide (NO2) is considered to be a measure of traffic-related air pollution, with concentrations tending to be higher near highways, along busy roads, and in the city centers, and the exceedances are mainly observed at measurement stations located close to traffic. In order to assess the air quality in the city and the air pollution impact on public health, air quality models are used. However, firstly, before the model can be used for these purposes, it is important to evaluate the accuracy of the dispersion modelling as one of the most widely used method. The monitoring and dispersion modelling are two components of air quality monitoring system (AQMS), in which statistical comparison was made in this research. The evaluation of the Atmospheric Dispersion Modelling System (ADMS-Urban) was made by comparing monthly modelled NO2 concentrations with the data of continuous air quality monitoring stations in Kaunas city. The statistical measures of model performance were calculated for annual and monthly concentrations of NO2 for each monitoring station site. The spatial analysis was made using geographic information systems (GIS). The calculation of statistical parameters indicated a good ADMS-Urban model performance for the prediction of NO2. The results of this study showed that the agreement of modelled values and observations was better for traffic monitoring stations compared to the background and residential stations. PMID:26293894

  8. Prediction of anaerobic biodegradability and bioaccessibility of municipal sludge by coupling sequential extractions with fluorescence spectroscopy: towards ADM1 variables characterization.

    PubMed

    Jimenez, Julie; Gonidec, Estelle; Cacho Rivero, Jesús Andrés; Latrille, Eric; Vedrenne, Fabien; Steyer, Jean-Philippe

    2014-03-01

    Advanced dynamic anaerobic digestion models, such as ADM1, require both detailed organic matter characterisation and intimate knowledge of the involved metabolic pathways. In the current study, a methodology for municipal sludge characterization is investigated to describe two key parameters: biodegradability and bioaccessibility of organic matter. The methodology is based on coupling sequential chemical extractions with 3D fluorescence spectroscopy. The use of increasingly strong solvents reveals different levels of organic matter accessibility and the spectroscopy measurement leads to a detailed characterisation of the organic matter. The results obtained from testing 52 municipal sludge samples (primary, secondary, digested and thermally treated) showed a successful correlation with sludge biodegradability and bioaccessibility. The two parameters, traditionally obtained through the biochemical methane potential (BMP) lab tests, are now obtain in only 5 days compared to the 30-60 days usually required. Experimental data, obtained from two different laboratory scale reactors, were used to validate the ADM1 model. The proposed approach showed a strong application potential for reactor design and advanced control of anaerobic digestion processes. PMID:24238878

  9. Building on Family Strengths: Research and Services in Support of Children and Their Families. Proceedings of the Building on Family Strengths Annual Conference (12th, Portland, Oregon, June 23-25, 2005)

    ERIC Educational Resources Information Center

    Gordon, Lyn, Ed.; Bradley, Jennifer, Ed.; Aue, Nicole, Ed.; Holman, Ariel, Ed.

    2006-01-01

    The 12th Annual Building on Family Strengths Conference was held from June 23rd through June 25th 2005 in Portland, Oregon. Highlights included: (1) An information-packed keynote address by Dr. Richard M. Lerner on promoting positive youth development through enhancing the assets of communities; (2) An exciting research plenary panel session that…

  10. Building on Family Strengths: Research and Services in Support of Children and Their Families. Proceedings of the Building on Family Strengths Annual Conference (11th, Portland, Oregon, May 6-8, 2004)

    ERIC Educational Resources Information Center

    Gordon, Lynwood J., Ed.; Tullis, Kathryn, Ed.; Hanson, Andrea, Ed.; Sowders, Stacey, Ed.

    2005-01-01

    The 11th Annual Building on Family Strengths Conference was held from May 6th through May 8th, 2004, in Portland, Oregon. Highlights included: (1) The revival of a pre-conference training session; this year featured "Understanding Research and Evaluation in Relation to Social Change," presented by Elaine Slaton and Shannon CrossBear of the…

  11. Building Awareness.

    ERIC Educational Resources Information Center

    Meilach, Dona Z.

    2001-01-01

    Discusses the importance of developing students' building awareness by exploring logos, or buildings that symbolize a country, to learn about architecture and the cultures in different countries. Explores categories of buildings. Includes examples of logos from around the world. (CMK)

  12. 75 FR 44264 - Federal Management Regulation; FMR Bulletin PBS-2010-B4; Redesignation of Federal Building

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ...: Public Buildings Service (P), General Services Administration. ACTION: Notice of a bulletin. SUMMARY: The... Administration, Public Buildings Service (P), Attn: David E. Foley, 1800 F Street, NW., Washington, DC 20405, e... this Federal building? U.S. General Services Administration, Public Buildings Service (P), Attn:...

  13. Detail view to show northwestern section of the building with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail view to show northwestern section of the building with its modified mansard roof - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

  14. The Determinants of Staff and Resident Activity in Residential Services for People with Severe Intellectual Disability: Moving beyond Size, Building Design, Location and Number of Staff.

    ERIC Educational Resources Information Center

    Felce, David

    1998-01-01

    Draws together the results of seven studies that investigated factors influencing the effects of service quality in community-based residential services for people with severe mental retardation. Results found that quality of staff and resident activity is dependent on an interaction between the structure, orientation, and procedures followed…

  15. High-dose adriamycin (ADM) and cis-platinum (DDP) in advanced soft-tissue sarcomas and invasive thymomas. A pilot study.

    PubMed

    Klippstein, T H; Mitrou, P S; Kochendörfer, K J; Bergmann, L

    1984-01-01

    Eighteen previously untreated patients with advanced unresectable or metastatic soft-tissue sarcomas (STS) and two patients with locally invasive thymoma were treated with a combination of adriamycin (ADM) 80 mg/m2 on day 1 and cis-platinum (DDP) 120 mg/m2 on day 1. The regimen was repeated at 4-weeks intervals. In STS the overall remission rate was 44%, with 21% complete remissions. The overall survival was 15 months (3-35+), responders surviving a median of 20 months (3-35+) and nonresponders, a median of 9 months (3-20+). Tumor responses lasted a median of 8 months (3-35+). Two patients with liposarcoma have now survived disease-free for at least 2 years and are potentially cured. The two patients with thymoma experienced complete remission lasting 4+ and 20+ months. Substantial hematologic toxicity was prominent, due to the high-doses used in this combination regimen. PMID:6540630

  16. Improving Evaluation in the Nonprofit Sector: The Promise of Evaluation Capacity Building for Nonprofit Social Service Organizations in an Age of Accountability

    ERIC Educational Resources Information Center

    Pejsa, Laura J.

    2011-01-01

    The purpose of this study was to explore the real-world practice of evaluation capacity building (ECB) in the small-medium sized nonprofit context. The study aimed to map the activities, processes, and outcomes of ECB in these nonprofits in light of the competing external and internal evaluation contexts facing nonprofits in an age of…

  17. Expanding Options. A Model to Attract Secondary Students into Nontraditional Vocational Programs. For Emphasis in: Building Trades, Electronics, Health Services, Machine Shop, Welding.

    ERIC Educational Resources Information Center

    Good, James D.; DeVore, Mary Ann

    This model has been designed for use by Missouri secondary schools in attracting females and males into nontraditional occupational programs. The research-based strategies are intended for implementation in the following areas: attracting females into building trades, electronics, machine shop, and welding; and males into secondary health…

  18. 7 CFR 1726.150 - Headquarters buildings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Headquarters buildings. 1726.150 Section 1726.150... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings. This section includes headquarters buildings such as warehouses and equipment service type...

  19. 7 CFR 1726.150 - Headquarters buildings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Headquarters buildings. 1726.150 Section 1726.150... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings. This section includes headquarters buildings such as warehouses and equipment service type...

  20. 7 CFR 1726.150 - Headquarters buildings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Headquarters buildings. 1726.150 Section 1726.150... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings. This section includes headquarters buildings such as warehouses and equipment service type...

  1. 7 CFR 1726.150 - Headquarters buildings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Headquarters buildings. 1726.150 Section 1726.150... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings. This section includes headquarters buildings such as warehouses and equipment service type...

  2. Technicians for Intelligent Buildings. Final Report.

    ERIC Educational Resources Information Center

    Prescott, Carolyn; Thomson, Ron

    "Intelligent building" is a term that has been coined in recent years to describe buildings in which computer technology is intensely applied in two areas of building operations: control systems and shared tenant services. This two-part study provides an overview of the intelligent building industry and reports on issues related to the training of…

  3. BUILDING 122 CONTAINS THREE GENERAL AREAS: OFFICE AREAS, INTERNAL DOSIMETRY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BUILDING 122 CONTAINS THREE GENERAL AREAS: OFFICE AREAS, INTERNAL DOSIMETRY, AND MEDICAL/HEALTH. BUILDING 122 SHARES A COMMON WALL WITH BUILDING 121, THE PLANT SECURITY BUILDING. THE TWO-STORY BUILDING IN THE BACKGROUND IS BUILDING 111. (9/26/52) - Rocky Flats Plant, Emergency Medical Services Facility, Southwest corner of Central & Third Avenues, Golden, Jefferson County, CO

  4. To designate the facility of the United States Postal Service located at 4110 Almeda Road in Houston, Texas, as the "George Thomas 'Mickey' Leland Post Office Building".

    THOMAS, 112th Congress

    Rep. Jackson Lee, Sheila [D-TX-18

    2011-01-05

    02/08/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  5. To designate the facility of the United States Postal Service located at 1900 West Gray Street in Houston, Texas, as the "Hazel Hainsworth Young Post Office Building".

    THOMAS, 112th Congress

    Rep. Jackson Lee, Sheila [D-TX-18

    2011-01-05

    02/08/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Federal Employee Family-Building Act of 1987. Hearing on H.R. 2852 before the Subcommittee on Civil Service of the Committee on Post Office and Civil Service. House of Representatives, One Hundredth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U. S., Washington, DC. House Committee on Post Office and Civil Service.

    A hearing was held to consider H.R. 2852, the Federal Employee Family-Building Act, a proposal that would require health insurance plans for federal employees to cover the costs of adoption and fertility treatments. Testimony concerned: (1) difficulties childless and infertile federal employees encountered in efforts to adopt and conceive…

  7. Building Community-Engaged Health Research and Discovery Infrastructure on the South Side of Chicago: Science in Service to Community Priorities

    PubMed Central

    Lindau, Stacy Tessler; Makelarski, Jennifer A.; Chin, Marshall H.; Desautels, Shane; Johnson, Daniel; Johnson, Waldo E.; Miller, Doriane; Peters, Susan; Robinson, Connie; Schneider, John; Thicklin, Florence; Watson, Natalie P.; Wolfe, Marcus; Whitaker, Eric

    2011-01-01

    Objective To describe the roles community members can and should play in, and an asset-based strategy used by Chicago’s South Side Health and Vitality Studies for, building sustainable, large-scale community health research infrastructure. The Studies are a family of research efforts aiming to produce actionable knowledge to inform health policy, programming, and investments for the region. Methods Community and university collaborators, using a consensus-based approach, developed shared theoretical perspectives, guiding principles, and a model for collaboration in 2008, which were used to inform an asset-based operational strategy. Ongoing community engagement and relationship-building support the infrastructure and research activities of the Studies. Results Key steps in the asset-based strategy include: 1) continuous community engagement and relationship building, 2) identifying community priorities, 3) identifying community assets, 4) leveraging assets, 5) conducting research, 6) sharing knowledge and 7) informing action. Examples of community member roles, and how these are informed by the Studies’ guiding principles, are provided. Conclusions Community and university collaborators, with shared vision and principles, can effectively work together to plan innovative, large-scale community-based research that serves community needs and priorities. Sustainable, effective models are needed to realize NIH’s mandate for meaningful translation of biomedical discovery into improved population health. PMID:21236295

  8. Exploring the use of the interactive systems framework to guide school mental health services in post-disaster contexts: building community capacity for trauma-focused interventions.

    PubMed

    Taylor, Leslie K; Weist, Mark D; DeLoach, Kendra

    2012-12-01

    Over the past two decades schools have been identified as the de facto mental health system for youth. Therefore, improving and expanding school mental health (SMH) has become a pressing agenda item for researchers, practitioners, policy makers, and funders. Advancing this agenda includes not only translating intervention research into practice within schools, but building capacities for these interventions to occur. The interactive systems framework (ISF) of Wandersman and colleagues, and the focus of this special issue, provides guidance in bridging the gap between research and practice through multisystem capacity building. There is some evidence that application of the ISF has helped to build capacity for SMH in states, but this evidence is preliminary. In addition, application of the ISF has not occurred in SMH at the community level or in relation to the specific stresses a community undergoes in relation to a disaster. The purpose of this article was to conduct a preliminary attempt to connect these three areas-the ISF, SMH and strengthening SMH through the ISF to better address impacts of a community level disaster; in this case, we explore the impacts of Hurricane Katrina on New Orleans schools, their students and families, and SMH programming within them. PMID:22434328

  9. Building national public health capacity for managing chemical events: A case study of the development of health protection services in the United Kingdom

    PubMed Central

    Palmer, Stephen; Coleman, Gary

    2013-01-01

    The revised International Health Regulations (2005) require that countries develop plans for chemical threats. In 2012, the World Health Assembly reported that most countries had not yet achieved ‘adequate capacity'. We review the evolution of chemical hazards services in the United Kingdom, the result of 15 years of grass-roots pressure and an accumulating weight of chemical incidents that eventually convinced the UK Department of Health of the need for a new national public health function, culminating, in 2003, in the creation of the Chemical Hazards Division of the new Health Protection Agency. Ten years later, public health services are again being radically reorganized with the creation of Public Health England, potentially destabilizing health protection arrangements and creating confusion among roles in managing chemical emergencies. Incorporating health protection into a broader public health organization, however, offers a new opportunity to broaden the scope of health protection services to embrace prevention of non-infectious environmental diseases. PMID:23447032

  10. 6. Detail of porch on east front of building. View ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Detail of porch on east front of building. View to southwest. - U.S. Customs Service Port of Roosville, Immigration & Naturalization Service Residence, 45 feet southwest of Main Port Building, Eureka, Lincoln County, MT

  11. 1. East front and north side of building. View to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. East front and north side of building. View to west. - U.S. Customs Service Port of Roosville, Immigration & Naturalization Service Residence, 45 feet southwest of Main Port Building, Eureka, Lincoln County, MT

  12. 5. East front and south side of building. View to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. East front and south side of building. View to northwest. - U.S. Customs Service Port of Roosville, Immigration & Naturalization Service Residence, 45 feet southwest of Main Port Building, Eureka, Lincoln County, MT

  13. 4. West rear and south side of building. View to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. West rear and south side of building. View to northeast. - U.S. Customs Service Port of Roosville, Immigration & Naturalization Service Residence, 45 feet southwest of Main Port Building, Eureka, Lincoln County, MT

  14. 2. North side and east front of building. View to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. North side and east front of building. View to southwest. - U.S. Customs Service Port of Roosville, U.S. Customs Service Residence, 45 feet northwest of Main Port Building, Eureka, Lincoln County, MT

  15. 3. West rear and north side of building. View to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West rear and north side of building. View to southeast. - U.S. Customs Service Port of Roosville, U.S. Customs Service Residence, 45 feet northwest of Main Port Building, Eureka, Lincoln County, MT

  16. 4. West rear and south side of building. View to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. West rear and south side of building. View to northeast. - U.S. Customs Service Port of Roosville, U.S. Customs Service Residence, 45 feet northwest of Main Port Building, Eureka, Lincoln County, MT

  17. 6. Detail of porch on east front of building. View ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Detail of porch on east front of building. View to southwest. - U.S. Customs Service Port of Roosville, U.S. Customs Service Residence, 45 feet northwest of Main Port Building, Eureka, Lincoln County, MT

  18. 2. VIEW SOUTHEAST, WEST FRONT OF BUILDINGS 25. 26; NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW SOUTHEAST, WEST FRONT OF BUILDINGS 25. 26; NORTH FRONT OF BUILDING 24: ROOF GABLE OF BUILDING 27 - U.S. Plant Introduction Station, Soil Conservation Service Cluster, 11601 Old Pond Road, Glenn Dale, Prince George's County, MD

  19. Building America

    SciTech Connect

    Brad Oberg

    2010-12-31

    IBACOS researched the constructability and viability issues of using high performance windows as one component of a larger approach to building houses that achieve the Building America 70% energy savings target.

  20. Intelligent buildings

    SciTech Connect

    Atkin, B.

    1989-01-01

    The term intelligent buildings refers to today's sophisticated living environments that must support communication, energy, fire and security protection systems. This book examines a variety of topics including building automation, information technology, and systems and facilities management.

  1. Building Language Educators: The Implications of Case-Based Pedagogy Using Practicum-Based Student-Teacher-Generated Cases for Pre-Service Language Teacher Education

    ERIC Educational Resources Information Center

    Cournoyer, Amy Beth

    2014-01-01

    This case study investigated case-based pedagogy using student-teacher-generated cases as an instructional tool in the preparation of 12 pre-service ESL, Bilingual, and Modern Foreign Language teachers enrolled in a Student Teaching Seminar at a post-secondary institution. In the fall methods course, each participant generated a case study based…

  2. Personal Capacity Building for the Human Services: The Roles of Curriculum and Individual Differences in Predicting Self-Concept in College/University Students

    ERIC Educational Resources Information Center

    Parker, Philip D.; Martin, Andrew J.

    2008-01-01

    While much research has outlined the importance of intra-psychic factors in predicting workplace success, it is rare that attention is given to the development of these factors in training for human service professions (e.g. psychology, clergy, nursing). Accordingly, the present study explores differences in self-concept, a key intra-psychic…

  3. What if You Build It and They Still Won't Come? Addressing Student Awareness of Resources and Services with Promotional Videos

    ERIC Educational Resources Information Center

    Dalal, Heather A.; Lackie, Robert J.

    2014-01-01

    After a needs assessment exposed that even daily library users were unaware of the best resources, tools, and services, the Rider University Libraries switched gears from a focus on the creation of long step-by-step tutorials, to the creation of short promotional videos for all users, with attention on the needs of distance learners. This project…

  4. To designate the facility of the United States Postal Service located at 6310 North University Street in Peoria, Illinois, as the "Charles 'Chip' Lawrence Chan Post Office Building".

    THOMAS, 112th Congress

    Rep. Schock, Aaron [R-IL-18

    2011-07-14

    08/18/2011 Committee on Homeland Security and Governmental Affairs referred to Subcommittee on Federal Financial Management, Government Information, Federal Services, and International Security. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  5. To designate the facility of the United States Postal Service located at 401 Old Dixie Highway in Jupiter, Florida, as the "Roy Schallern Rood Post Office Building".

    THOMAS, 112th Congress

    Rep. Rooney, Thomas J. [R-FL-16

    2011-12-12

    03/14/2012 Committee on Homeland Security and Governmental Affairs referred to Subcommittee on Federal Financial Management, Government Information, Federal Services, and International Security. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  6. The State of Preservation Programs in American College and Research Libraries: Building a Common Understanding and Action Agenda. Optimizing Collections and Services for Scholarly Use.

    ERIC Educational Resources Information Center

    Kenney, Anne R.; Stam, Deirdre C.

    With funding from the Institute for Museum and Library Services, the Council on Library and Information Resources, ARL (Association of Research Libraries), the University Libraries Group, and the Regional Alliance for Preservation conducted a joint study in 2001 to examine the state of preservation programs in American academic libraries. The…

  7. How Local Farmers and School Food Service Buyers Are Building Alliances: Lessons Learned from the USDA Small Farm/School Meals Workshop, May 1, 2000.

    ERIC Educational Resources Information Center

    Tropp, Debra; Olowolayemo, Surajudeen

    This report summarizes the educational highlights of a workshop sponsored by the U.S. Department of Agriculture, the University of Kentucky's Cooperative Extension Service, and the Kentucky Department of Agriculture aimed at boosting the use of locally produced fresh food in school feeding programs. The workshop was designed to provide a forum for…

  8. Healthy Buildings?

    ERIC Educational Resources Information Center

    Grubb, Deborah

    Health problems related to school buildings can be categorized in five major areas: sick-building syndrome; health-threatening building materials; environmental hazards such as radon gas and asbestos; lead poisoning; and poor indoor air quality due to smoke, chemicals, and other pollutants. This paper provides an overview of these areas,…

  9. Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway.

    PubMed

    Chen, Jie-Ru; Jia, Xiu-Hong; Wang, Hong; Yi, Ying-Jie; Wang, Jian-Yong; Li, You-Jie

    2016-05-01

    One of the major causes of failure in chemotherapy for patients with human chronic myelogenous leukemia (CML) is the acquisition of multidrug resistance (MDR). MDR is often associated with the overexpression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. Timosaponin A-III (TAIII), a saponin isolated from the rhizome of Anemarrhena asphodeloides, has previously demonstrated the ability to suppress certain human tumor processes and the potential to be developed as an anticancer agent. Nevertheless, the ability of TAIII to reverse MDR has not yet been explored. In this study, the adriamycin (ADM) resistance reversal effect of TAIII in human CML K562/ADM cells and the underlying mechanism was investigated. The Cell Counting Kit-8 (CCK-8) assay showed that TAIII had a reversal effect on the drug resistance of K562/ADM cells. Flow cytometry assay showed increased intracellular accumulation of ADM after cells were pretreated with TAIII, and the changes in the accumulation of rhodamine-123 (Rho-123) and 5(6)-carboxyfluorescein diacetate (CFDA) dye in K562/ADM cells were determined to be similar to the changes of intracellular accumulation of ADM. After pretreatment of cells with TAIII, the decreasing expression of P-gp and MRP1 mRNA was examined by reverse transcription polymerase chain reaction (RT-PCR). Western blotting showed TAIII inhibiting P-gp and MRP1 expression depended on the PI3K/Akt signaling pathway by decreasing the activity of p-Akt. Moreover, wortmannin an inhibitor of PI3K/Akt signaling pathway has a strong inhibitory effect on the expression of p-Akt, P-gp and MRP1. Besides, the combined treatment with TAIII did not have an affect on wortmannin downregulation of p-Akt, P-gp and MRP1. Taken together, our findings demonstrate, for the first time, that TAIII induced MDR reversal through inhibition of P-gp and MRP1 expression and function with regained adriamycin sensitivity which might mainly correlate to the regulation of PI3K

  10. Scotts Valley Energy Office and Human Capacity Building that will provide energy-efficiency services and develop sustainable renewable energy projects.

    SciTech Connect

    Anderson, Temashio

    2013-06-28

    The primary goal of this project is to develop a Scotts Valley Energy Development Office (SVEDO). This office will further support the mission of the Tribe's existing leadership position as the DOE Tribal Multi-County Weatherization Energy Program (TMCWEP) in creating jobs and providing tribal homes and buildings with weatherization assistance to increase energy efficiency, occupant comfort and improved indoor air quality. This office will also spearhead efforts to move the Tribe towards its further strategic energy goals of implementing renewable energy systems through specific training, resource evaluation, feasibility planning, and implementation. Human capacity building and continuing operations are two key elements of the SVEDO objectives. Therefore, the project will 1) train and employ additional Tribal members in energy efficiency, conservation and renewable resource analyses and implementation; 2) purchase materials and equipment required to implement the strategic priorities as developed by the Scotts Valley Tribe which specifically include implementing energy conservation measures and alternative energy strategies to reduce energy costs for the Tribe and its members; and 3) obtain a dedicated office and storage space for ongoing SVEDO operations.

  11. Building and evaluating an informatics tool to facilitate analysis of a biomedical literature search service in an academic medical center library.

    PubMed

    Hinton, Elizabeth G; Oelschlegel, Sandra; Vaughn, Cynthia J; Lindsay, J Michael; Hurst, Sachiko M; Earl, Martha

    2013-01-01

    This study utilizes an informatics tool to analyze a robust literature search service in an academic medical center library. Structured interviews with librarians were conducted focusing on the benefits of such a tool, expectations for performance, and visual layout preferences. The resulting application utilizes Microsoft SQL Server and .Net Framework 3.5 technologies, allowing for the use of a web interface. Customer tables and MeSH terms are included. The National Library of Medicine MeSH database and entry terms for each heading are incorporated, resulting in functionality similar to searching the MeSH database through PubMed. Data reports will facilitate analysis of the search service. PMID:23869631

  12. FAST CHOPPER BUILDING, TRA665. CONTEXTUAL VIEW: CHOPPER BUILDING IN CENTER. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FAST CHOPPER BUILDING, TRA-665. CONTEXTUAL VIEW: CHOPPER BUILDING IN CENTER. MTR REACTOR SERVICES BUILDING,TRA-635, TO LEFT; MTR BUILDING TO RIGHT. CAMERA FACING WEST. INL NEGATIVE NO. HD42-1. Mike Crane, Photographer, 3/2004 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  13. Super Kitchen Centralizes Food Service

    ERIC Educational Resources Information Center

    Modern Schools, 1975

    1975-01-01

    To centralize food service within the entire Pittsburgh school district, a 90,000-square-foot food service preparation building contains cranes and monorails to move 500-pound capacity vats throughout the kitchen. (Author/MLF)

  14. 75 FR 69080 - Federal Management Regulation; FMR Bulletin PBS-2010-B5; Redesignations of Federal Buildings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... AGENCY: Public Buildings Service (P), General Services Administration. ACTION: Notice of a bulletin... CONTACT: U.S. General Services Administration, Public Buildings Service (P), Attn: David E. Foley, 1800 F... and redesignation of these Federal buildings? U.S. General Services Administration, Public...

  15. Facility Focus: Food Service.

    ERIC Educational Resources Information Center

    College Planning & Management, 2002

    2002-01-01

    Describes the Hawthorn Court Community Center at Iowa State University, Ames, and the HUB-Robeson Center at Pennsylvania State University. Focuses on the food service offered in these new student-life buildings. Includes photographs. (EV)

  16. Building on the EGIPPS performance assessment: the multipolar framework as a heuristic to tackle the complexity of performance of public service oriented health care organisations

    PubMed Central

    2014-01-01

    Background Performance of health care systems is a key concern of policy makers and health service managers all over the world. It is also a major challenge, given its multidimensional nature that easily leads to conceptual and methodological confusion. This is reflected by a scarcity of models that comprehensively analyse health system performance. Discussion In health, one of the most comprehensive performance frameworks was developed by the team of Leggat and Sicotte. Their framework integrates 4 key organisational functions (goal attainment, production, adaptation to the environment, and values and culture) and the tensions between these functions. We modified this framework to better fit the assessment of the performance of health organisations in the public service domain and propose an analytical strategy that takes it into the social complexity of health organisations. The resulting multipolar performance framework (MPF) is a meta-framework that facilitates the analysis of the relations and interactions between the multiple actors that influence the performance of health organisations. Summary Using the MPF in a dynamic reiterative mode not only helps managers to identify the bottlenecks that hamper performance, but also the unintended effects and feedback loops that emerge. Similarly, it helps policymakers and programme managers at central level to better anticipate the potential results and side effects of and required conditions for health policies and programmes and to steer their implementation accordingly. PMID:24742181

  17. Laboratory Building.

    SciTech Connect

    Herrera, Joshua M.

    2015-03-01

    This report is an analysis of the means of egress and life safety requirements for the laboratory building. The building is located at Sandia National Laboratories (SNL) in Albuquerque, NM. The report includes a prescriptive-based analysis as well as a performance-based analysis. Following the analysis are appendices which contain maps of the laboratory building used throughout the analysis. The top of all the maps is assumed to be north.

  18. Building Strengths in the Neighborhood

    ERIC Educational Resources Information Center

    Quigley, Richard

    2005-01-01

    This article features Woodland Hills's Neighborhood Youth Services. The Neighborhood Youth Services (NYS) program is a community-based program created by Woodland Hills, a residential program for troubled adolescents in Duluth, Minnesota. Principles for building respectful adult and peer relationships developed in the treatment environment were…

  19. Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.

    PubMed

    Alehagen, Urban; Aaseth, Jan; Johansson, Peter

    2015-01-01

    Intervention with selenium and coenzyme Q10 have recently been found to reduce mortality and increase cardiac function. The mechanisms behind these effects are unclear. As selenium and coenzyme Q10 is involved in the anti-oxidative defence, the present study aimed to evaluate effects of selenium and coenzyme Q10 on copeptin and adrenomedullin as oxidative stress biomarkers. Therefore 437 elderly individuals were included and given intervention for 4 years. Clinical examination and blood samples were undertaken at start and after 18 and 48 months. Evaluations of copeptin and MR-proADM changes were performed using repeated measures of variance. Cardiovascular mortality was evaluated using a 10-year-period of follow-up, and presented in Kaplan-Meier plots. A significant increase in copeptin level could be seen in the placebo group during the intervention period (from 9.4 pmol/L to 15.3 pmol/L), compared to the active treatment group. The difference between the groups was confirmed in the repeated measurement of variance analyses (P = 0.031) with less copeptin increase in the active treatment group. Furthermore, active treatment appeared to protect against cardiovascular death both in those with high and with low copeptin levels at inclusion. Less increase of MR-proADM could also be seen during the intervention in the active treatment group compared to controls (P = 0.026). Both in those having an MR-proADM level above or below median level, significantly less cardiovascular mortality could be seen in the active treatment group (P = 0.0001, and P = 0.04 respectively). In conclusion supplementation with selenium and coenzyme Q10 during four years resulted in less concentration of both copeptin and MR-proADM. A cardioprotective effect of the supplementation was registered, irrespective of the initial levels of these biomarkers, and this protection was recognized also after 10 years of observation. PMID:26662217

  20. A study of the atmospheric dispersion of a high release of krypton-85 above a complex coastal terrain, comparison with the predictions of Gaussian models (Briggs, Doury, ADMS4).

    PubMed

    Leroy, C; Maro, D; Hébert, D; Solier, L; Rozet, M; Le Cavelier, S; Connan, O

    2010-11-01

    Atmospheric releases of krypton-85, from the nuclear fuel reprocessing plant at the AREVA NC facility at La Hague (France), were used to test Gaussian models of dispersion. In 2001-2002, the French Institute for Radiological Protection and Nuclear Safety (IRSN) studied the atmospheric dispersion of 15 releases, using krypton-85 as a tracer for plumes emitted from two 100-m-high stacks. Krypton-85 is a chemically inert radionuclide. Krypton-85 air concentration measurements were performed on the ground in the downwind direction, at distances between 0.36 and 3.3 km from the release, by neutral or slightly unstable atmospheric conditions. The standard deviation for the horizontal dispersion of the plume and the Atmospheric Transfer Coefficient (ATC) were determined from these measurements. The experimental results were compared with calculations using first generation (Doury, Briggs) and second generation (ADMS 4.0) Gaussian models. The ADMS 4.0 model was used in two configurations; one takes account of the effect of the built-up area, and the other the effect of the roughness of the surface on the plume dispersion. Only the Briggs model correctly reproduced the measured values for the width of the plume, whereas the ADMS 4.0 model overestimated it and the Doury model underestimated it. The agreement of the models with measured values of the ATC varied according to distance from the release point. For distances less than 2 km from the release point, the ADMS 4.0 model achieved the best agreement between model and measurement; beyond this distance, the best agreement was achieved by the Briggs and Doury models. PMID:20638159

  1. Buildings Interoperability Landscape

    SciTech Connect

    Hardin, Dave; Stephan, Eric G.; Wang, Weimin; Corbin, Charles D.; Widergren, Steven E.

    2015-12-31

    Through its Building Technologies Office (BTO), the United States Department of Energy’s Office of Energy Efficiency and Renewable Energy (DOE-EERE) is sponsoring an effort to advance interoperability for the integration of intelligent buildings equipment and automation systems, understanding the importance of integration frameworks and product ecosystems to this cause. This is important to BTO’s mission to enhance energy efficiency and save energy for economic and environmental purposes. For connected buildings ecosystems of products and services from various manufacturers to flourish, the ICT aspects of the equipment need to integrate and operate simply and reliably. Within the concepts of interoperability lie the specification, development, and certification of equipment with standards-based interfaces that connect and work. Beyond this, a healthy community of stakeholders that contribute to and use interoperability work products must be developed. On May 1, 2014, the DOE convened a technical meeting to take stock of the current state of interoperability of connected equipment and systems in buildings. Several insights from that meeting helped facilitate a draft description of the landscape of interoperability for connected buildings, which focuses mainly on small and medium commercial buildings. This document revises the February 2015 landscape document to address reviewer comments, incorporate important insights from the Buildings Interoperability Vision technical meeting, and capture thoughts from that meeting about the topics to be addressed in a buildings interoperability vision. In particular, greater attention is paid to the state of information modeling in buildings and the great potential for near-term benefits in this area from progress and community alignment.

  2. Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.

    PubMed

    Chua, Eng Wee; Cree, Simone L; Ton, Kim N T; Lehnert, Klaus; Shepherd, Phillip; Helsby, Nuala; Kennedy, Martin A

    2016-01-01

    Whole-exome sequencing (WES) has been widely used for analysis of human genetic diseases, but its value for the pharmacogenomic profiling of individuals is not well studied. Initially, we performed an in-depth evaluation of the accuracy of WES variant calling in the pharmacogenes CYP2D6 and CYP2C19 by comparison with MiSeq(®) amplicon sequencing data (n = 36). This analysis revealed that the concordance rate between WES and MiSeq(®) was high, achieving 99.60% for variants that were called without exceeding the truth-sensitivity threshold (99%), defined during variant quality score recalibration (VQSR). Beyond this threshold, the proportion of discordant calls increased markedly. Subsequently, we expanded our findings beyond CYP2D6 and CYP2C19 to include more genes genotyped by the iPLEX(®) ADME PGx Panel in the subset of twelve samples. WES performed well, agreeing with the genotyping panel in approximately 99% of the selected pass-filter variant calls. Overall, our results have demonstrated WES to be a promising approach for pharmacogenomic profiling, with an estimated error rate of lower than 1%. Quality filters, particularly VQSR, are important for reducing the number of false variants. Future studies may benefit from examining the role of WES in the clinical setting for guiding drug therapy. PMID:26858644

  3. Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX® ADME PGx Panel for Pharmacogenomic Profiling

    PubMed Central

    Chua, Eng Wee; Cree, Simone L.; Ton, Kim N. T.; Lehnert, Klaus; Shepherd, Phillip; Helsby, Nuala; Kennedy, Martin A.

    2016-01-01

    Whole-exome sequencing (WES) has been widely used for analysis of human genetic diseases, but its value for the pharmacogenomic profiling of individuals is not well studied. Initially, we performed an in-depth evaluation of the accuracy of WES variant calling in the pharmacogenes CYP2D6 and CYP2C19 by comparison with MiSeq® amplicon sequencing data (n = 36). This analysis revealed that the concordance rate between WES and MiSeq® was high, achieving 99.60% for variants that were called without exceeding the truth-sensitivity threshold (99%), defined during variant quality score recalibration (VQSR). Beyond this threshold, the proportion of discordant calls increased markedly. Subsequently, we expanded our findings beyond CYP2D6 and CYP2C19 to include more genes genotyped by the iPLEX® ADME PGx Panel in the subset of twelve samples. WES performed well, agreeing with the genotyping panel in approximately 99% of the selected pass-filter variant calls. Overall, our results have demonstrated WES to be a promising approach for pharmacogenomic profiling, with an estimated error rate of lower than 1%. Quality filters, particularly VQSR, are important for reducing the number of false variants. Future studies may benefit from examining the role of WES in the clinical setting for guiding drug therapy. PMID:26858644

  4. Bacterial Peptide deformylase inhibition of cyano substituted biaryl analogs: Synthesis, in vitro biological evaluation, molecular docking study and in silico ADME prediction.

    PubMed

    Khan, Firoz A Kalam; Patil, Rajendra H; Shinde, Devanand B; Sangshetti, Jaiprakash N

    2016-08-15

    Herein, we report the synthesis and screening of cyano substituted biaryl analogs 5(a-m) as Peptide deformylase (PDF) enzyme inhibitors. The compounds 5a (IC50 value=13.16μM), 5d (IC50 value=15.66μM) and 5j (IC50 value=19.16μM) had shown good PDF inhibition activity. The compounds 5a (MIC range=11.00-15.83μg/mL), 5b (MIC range=23.75-28.50μg/mL) and 5j (MIC range=7.66-16.91μg/mL) had also shown potent antibacterial activity when compared with ciprofloxacin (MIC range=25-50μg/mL). Thus, the active derivatives were not only potent PDF inhibitors but also efficient antibacterial agents. In order to gain more insight on the binding mode of the compounds with PDF, the synthesized compounds 5(a-m) were docked against PDF enzyme of Escherichia coli and compounds exhibited good binding properties. In silico ADME properties of synthesized compounds were also analyzed and showed potential to develop as good oral drug candidates. PMID:27269198

  5. Modelling the anaerobic digestion of solid organic waste - Substrate characterisation method for ADM1 using a combined biochemical and kinetic parameter estimation approach.

    PubMed

    Poggio, D; Walker, M; Nimmo, W; Ma, L; Pourkashanian, M

    2016-07-01

    This work proposes a novel and rigorous substrate characterisation methodology to be used with ADM1 to simulate the anaerobic digestion of solid organic waste. The proposed method uses data from both direct substrate analysis and the methane production from laboratory scale anaerobic digestion experiments and involves assessment of four substrate fractionation models. The models partition the organic matter into a mixture of particulate and soluble fractions with the decision on the most suitable model being made on quality of fit between experimental and simulated data and the uncertainty of the calibrated parameters. The method was tested using samples of domestic green and food waste and using experimental data from both short batch tests and longer semi-continuous trials. The results showed that in general an increased fractionation model complexity led to better fit but with increased uncertainty. When using batch test data the most suitable model for green waste included one particulate and one soluble fraction, whereas for food waste two particulate fractions were needed. With richer semi-continuous datasets, the parameter estimation resulted in less uncertainty therefore allowing the description of the substrate with a more complex model. The resulting substrate characterisations and fractionation models obtained from batch test data, for both waste samples, were used to validate the method using semi-continuous experimental data and showed good prediction of methane production, biogas composition, total and volatile solids, ammonia and alkalinity. PMID:27156366

  6. Comparison of RIMPUFF, HYSPLIT, ADMS atmospheric dispersion model outputs, using emergency response procedures, with (85)Kr measurements made in the vicinity of nuclear reprocessing plant.

    PubMed

    Connan, Olivier; Smith, Kilian; Organo, Catherine; Solier, Luc; Maro, Denis; Hébert, Didier

    2013-10-01

    The Institut de Radioprotection et de Sureté Nucléaire (IRSN) performed a series of (85)Kr air sampling campaigns at mesoscale distances (18-50 km) from the AREVA NC La Hague nuclear reprocessing plant (North West France) between 2007 and 2009. The samples were collected in order to test and optimise a technique to measure low krypton-85 ((85)Kr) air concentrations and to investigate the performance of three atmospheric dispersion models (RIMPUFF, HYSPLIT, and ADMS), This paper presents the (85)Kr air concentrations measured at three sampling locations which varied from 2 to 8000 Bq m(-3), along with the (85)Kr air concentrations output by the dispersion models. The dispersion models made reasonable estimates of the mean concentrations of (85)Kr field measurements during steady wind conditions. In contrast, the models failed to accurately predict peaks in (85)Kr air concentration during periods of rapid and large changes in wind speed and/or wind direction. At distances where we made the comparisons (18-50 km), in all cases, the models underestimated the air concentration activities. PMID:23850583

  7. Novel amalgamation of phthalazine-quinolines as biofilm inhibitors: One-pot synthesis, biological evaluation and in silico ADME prediction with favorable metabolic fate.

    PubMed

    Zaheer, Zahid; Khan, Firoz A Kalam; Sangshetti, Jaiprakash N; Patil, Rajendra H; Lohar, K S

    2016-04-01

    A facile and highly efficient one-pot synthesis of phthalazine-quinoline derivatives is reported via four component reaction of phthalic anhydride, hydrazine hydrate, 5,5-dimethyl 1,3 cyclohexanedione and various quinoline aldehydes using PrxCoFe2-xO4 (x=0.1) nanoparticles as a catalyst. The synthesized compounds have been evaluated for anti-biofilm activity against Pseudomonas aeruginosa and Candida albicans. The compounds 12a (IC50=30.0μM) and 12f (IC50=34.5μM) had shown promising anti-biofilm activity against P. aeruginosa and C. albicans, respectively, when compared with standards without affecting the growth of cells (and thus behave as anti-quorum sensing agents). Compounds 12a (MIC=45.0μg/mL) and 12f (MIC=57.5μg/mL) showed significant potent antimicrobial activity against P. aeruginosa and C. albicans, respectively. Thus, the active derivatives were not only potent biofilm inhibitors but also efficient antimicrobial agents. In silico ADME and metabolic site prediction studies were also held out to set an effective lead candidate for the future antimicrobial drug discovery initiatives. PMID:26923699

  8. Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines

    PubMed Central

    Qian, Jun-Qiang; Sun, Pei; Pan, Zhan-Yu; Fang, Zhi-Zhong

    2015-01-01

    Hepatocellular carcinoma (HCC) is the most common tumor in worldwide and chemotherapy resistant is a severe obstacle in HCC treatment. Annonaceous acetogenins was a nature compound from Uvaria accuminata and it has show the anti-tumor proliferation activity in many types cancer. In this study, we showed that annonaceous acetogenins is correlated with the drug resistance reversal in human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines. We found that cell apoptosis was improved and cell cycle was arrested, further, multidrug-resistance proteins such as MDR1, MRP1, Topo-IIα, GST-π, cyclin D1, Survivin and bcl-2 are down-regulated, however, intracellular Rh-123 and caspase-3/8 was up-regulated by Annonaceous acetogenins treatment. We also found that there was a decreased activity of NF-κB and Akt in Annonaceous acetogenins treatment groups. Therefore, we demonstrate that Akt/NF-κB pathway was involved in Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma cells. PMID:26617951

  9. 3. ROADWAY TO THE SOUTH OF BUILDING NO. 1. AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. ROADWAY TO THE SOUTH OF BUILDING NO. 1. AT FAR LEFT IS THE SHADOW OF BUILDING NO. 6 (WAREHOUSE). ALSO VISIBLE AT THE LEFT IS BUILDING NO. 4 (BOILER HOUSE), BUILDING NO. 3 (GATE HOUSE), AND BUILDING NO. 2 (OFFICE BUILDING). IN THE RIGHT FOREGROUND IS BUILDING NO. 10 (ELECTRICAL SERVICES AND SWITCHING STATION). - United Engineering Company Shipyard, 2900 Main Street, Alameda, Alameda County, CA

  10. Capitalizing on Community Resources to Build Specialized Behavioral Health Services Together with Persons who are Deaf, Deafblind or Hard of Hearing.

    PubMed

    Mathos, Kimberly K; Pollard, Robert Q

    2016-02-01

    There are relatively few counselors, psychologists, psychiatrists, and social workers who specialize in serving people who are Deaf, Deafblind or hard of hearing in the United States. Professionals that serve minority populations are often an insular group. They tend to network most often with fellow professionals who understand the language and cultural needs of their service population. Such specialized behavioral health providers rarely have the opportunity to interface with "mainstream" program planners, funders and administrators. Consequently, new recovery agendas, best practice models and community reintegration ideas are only slowly integrated into the care of persons who are Deaf, Deafblind or hard of hearing. We describe the development and implementation of a task force comprised of "front line" providers, administrators, county government officials, advocates and consumers that has made strides toward effective change in a local behavioral health care system. Methods employed, successes, barriers and other reflections on the task force's efforts also are described. PMID:26507549

  11. 21 CFR 226.20 - Buildings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Buildings. 226.20 Section 226.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES Construction and Maintenance of Facilities and Equipment § 226.20 Buildings. Buildings...

  12. Using the framework of corporate culture in “mergers” to support the development of a cultural basis for integrative medicine – guidance for building an integrative medicine department or service

    PubMed Central

    Witt, Claudia M; Pérard, Marion; Berman, Brian; Berman, Susan; Birdsall, Timothy C; Defren, Horst; Kümmel, Sherko; Deng, Gary; Dobos, Gustav; Drexler, Atje; Holmberg, Christine; Horneber, Markus; Jütte, Robert; Knutson, Lori; Kummer, Christopher; Volpers, Susanne; Schweiger, David

    2015-01-01

    Background An increasing number of clinics offer complementary or integrative medicine services; however, clear guidance about how complementary medicine could be successfully and efficiently integrated into conventional health care settings is still lacking. Combining conventional and complementary medicine into integrative medicine can be regarded as a kind of merger. In a merger, two or more organizations − usually companies − are combined into one in order to strengthen the companies financially and strategically. The corporate culture of both merger partners has an important influence on the integration. Purpose The aim of this project was to transfer the concept of corporate culture in mergers to the merging of two medical systems. Methods A two-step approach (literature analyses and expert consensus procedure) was used to develop practical guidance for the development of a cultural basis for integrative medicine, based on the framework of corporate culture in “mergers,” which could be used to build an integrative medicine department or integrative medicine service. Results Results include recommendations for general strategic dimensions (definition of the medical model, motivation for integration, clarification of the available resources, development of the integration team, and development of a communication strategy), and recommendations to overcome cultural differences (the clinic environment, the professional language, the professional image, and the implementation of evidence-based medicine). Conclusion The framework of mergers in corporate culture provides an understanding of the difficulties involved in integrative medicine projects. The specific recommendations provide a good basis for more efficient implementation. PMID:25632226

  13. The Research Library and the E-Science Challenge: New Roles Building on Expanding Responsibilities in Service of the Science Community

    NASA Astrophysics Data System (ADS)

    Neal, J. G.

    2008-12-01

    Research libraries provide a set of core services to the scholarly and educational communities. This includes: information acquisition, synthesis, navigation, discovery, dissemination, interpretation, presentation, understanding and archiving. Researchers across the science disciplines and increasingly in multi disciplinary projects are producing massive amounts of data, and they seek the infrastructure, the strategies and the partnerships that will enable rigorous and sustained tools for extraction, distribution, collaboration, application and permanent availability. This paper will address the role of the research library from three perspectives. First, the view of scientific datasets as information assets that would benefit from traditional library collection development practice will be explored. Second, the agenda on e-science developed by the Association of Research Libraries will be outlined with a focus on the need for policy and standards development, for resources assessment and allocation, for new approaches to the preparation of the library professional, and library leadership in campus planning and innovative collaborations for research cyberinfrastructure. And third, the responses to the call for proposals from the National Science Foundation's DataNet program will be analyzed and the role of the research library in these project plans will be summarized as an indicator of the expanding responsibility of the library for research data stewardship.

  14. Building Change into New Buildings.

    ERIC Educational Resources Information Center

    DeJong, William S.

    1997-01-01

    Whether renovating or constructing a school building, planners must give serious thought to how a building might accommodate different instructional approaches and avoid traffic or supervision nightmares. Planners must also consider aesthetics, community-school partnerships, and educational technology's role. A sidebar by James Fox and Kay Psencik…

  15. Water Conservation: A Tool to Build Understanding, Service and Awareness about Natural Resources Linda Ruiz McCall, Katherine K. Ellins, and Bridget Cameron

    NASA Astrophysics Data System (ADS)

    McCall, L. R.; Ellins, K. K.; Cameron, B.

    2010-12-01

    Water is arguably our most important natural resource, essential for sustaining life on Earth; necessary to support agriculture and industry; and important for fisheries, power, navigation, and recreation. As world population increases and climate change brings about a redistribution of water and people across our planet, water resource management and conservation are increasingly important. Based on current population projections for Texas, about 85 percent of the state’s projected population will not have enough water by 2060 in drought conditions. Water conservation is critical for meeting the state’s long-term water needs. To that end, the Texas Water Development Board (TWDB) is engaged in a number of education and outreach programs. In this paper, we report on three TWDB educational campaigns. Water Exploration, a Web-based water resources education program for Texas high school students, Put Some Blue in Your Green School, a service learning project designed to promote interaction between schools and their local communities, and Water IQ: Know Your Water, a public awareness campaign for water conservation. Water Exploration uses a pedagogical approach called the Legacy Cycle to involve students in experiential, project-based learning to help them achieve a deeper understanding about water resources. It addresses the need for rigorous curriculum in a vitally important area for the new Texas high school Earth and Space Science Capstone course, as well as Environmental Systems, and Aquatic Science. The interdisciplinary nature of the curriculum encourages students to explore the connections between water resources and economics (water planning, water as a commodity), history (water affects human settlement and migration), and biology (water is essential for life; contaminated water affects living organisms). The ability to integrate information from different disciplines and weigh the perspectives of multiple experts is particularly important for solving the

  16. Building Portfolio

    ERIC Educational Resources Information Center

    College Management, 1974

    1974-01-01

    The combination of a prefabricated building system and a clustered terrace design has resulted in economical and aesthetically pleasing housing for students at Vassar College in Poughkeepsie, New York. (Author)

  17. 76 FR 54772 - Federal Management Regulation; FMR Bulletin PBS-2011-B2; Redesignations of Federal Buildings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... ADMINISTRATION Federal Management Regulation; FMR Bulletin PBS-2011-B2; Redesignations of Federal Buildings AGENCY: Public Buildings Service (P), General Services Administration. ACTION: Notice of a bulletin... CONTACT: U.S. General Services Administration, Public Buildings Service (P), Attn: David E. Foley, 1800...

  18. To build capacity, build confidence

    NASA Astrophysics Data System (ADS)

    Hewitson, Bruce

    2015-07-01

    The history of attempts to spread scientific know-how beyond western centres of excellence is littered with failures. Capacity building needs long-term commitment, a critical mass of trainees, and a supportive home environment.

  19. 76 FR 52718 - Complaint About Postal Services

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Postal Service's delivery of mail to residents of certain multi-unit buildings, and that the Postal... delivery the Postal Service provides to residents of single-room occupancy buildings (SROs) in San... under Postal Service regulations specifying the ``single-point'' mode of delivery for hotels,...

  20. Metrics for building performance assurance

    SciTech Connect

    Koles, G.; Hitchcock, R.; Sherman, M.

    1996-07-01

    This report documents part of the work performed in phase I of a Laboratory Directors Research and Development (LDRD) funded project entitled Building Performance Assurances (BPA). The focus of the BPA effort is to transform the way buildings are built and operated in order to improve building performance by facilitating or providing tools, infrastructure, and information. The efforts described herein focus on the development of metrics with which to evaluate building performance and for which information and optimization tools need to be developed. The classes of building performance metrics reviewed are (1) Building Services (2) First Costs, (3) Operating Costs, (4) Maintenance Costs, and (5) Energy and Environmental Factors. The first category defines the direct benefits associated with buildings; the next three are different kinds of costs associated with providing those benefits; the last category includes concerns that are broader than direct costs and benefits to the building owner and building occupants. The level of detail of the various issues reflect the current state of knowledge in those scientific areas and the ability of the to determine that state of knowledge, rather than directly reflecting the importance of these issues; it intentionally does not specifically focus on energy issues. The report describes work in progress and is intended as a resource and can be used to indicate the areas needing more investigation. Other reports on BPA activities are also available.

  1. Building Energy Monitoring and Analysis

    SciTech Connect

    Hong, Tianzhen; Feng, Wei; Lu, Alison; Xia, Jianjun; Yang, Le; Shen, Qi; Im, Piljae; Bhandari, Mahabir

    2013-06-01

    U.S. and China are the world’s top two economics. Together they consumed one-third of the world’s primary energy. It is an unprecedented opportunity and challenge for governments, researchers and industries in both countries to join together to address energy issues and global climate change. Such joint collaboration has huge potential in creating new jobs in energy technologies and services. Buildings in the US and China consumed about 40% and 25% of the primary energy in both countries in 2010 respectively. Worldwide, the building sector is the largest contributor to the greenhouse gas emission. Better understanding and improving the energy performance of buildings is a critical step towards sustainable development and mitigation of global climate change. This project aimed to develop a standard methodology for building energy data definition, collection, presentation, and analysis; apply the developed methods to a standardized energy monitoring platform, including hardware and software, to collect and analyze building energy use data; and compile offline statistical data and online real-time data in both countries for fully understanding the current status of building energy use. This helps decode the driving forces behind the discrepancy of building energy use between the two countries; identify gaps and deficiencies of current building energy monitoring, data collection, and analysis; and create knowledge and tools to collect and analyze good building energy data to provide valuable and actionable information for key stakeholders.

  2. Integrated Building Management System (IBMS)

    SciTech Connect

    Anita Lewis

    2012-07-01

    This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment without interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.

  3. Data management for biofied building

    NASA Astrophysics Data System (ADS)

    Matsuura, Kohta; Mita, Akira

    2015-03-01

    Recently, Smart houses have been studied by many researchers to satisfy individual demands of residents. However, they are not feasible yet as they are very costly and require many sensors to be embedded into houses. Therefore, we suggest "Biofied Building". In Biofied Building, sensor agent robots conduct sensing, actuation, and control in their house. The robots monitor many parameters of human lives such as walking postures and emotion continuously. In this paper, a prototype network system and a data model for practical application for Biofied Building is pro-posed. In the system, functions of robots and servers are divided according to service flows in Biofield Buildings. The data model is designed to accumulate both the building data and the residents' data. Data sent from the robots and data analyzed in the servers are automatically registered into the database. Lastly, feasibility of this system is verified through lighting control simulation performed in an office space.

  4. Surveys for Asbestos of All State-Owned Buildings and All Public Schools: Report of the Department of General Services to the Governor and the General Assembly of Virginia. Senate Document No. 27.

    ERIC Educational Resources Information Center

    Virginia State Dept. of General Services, Richmond.

    Addressed to the members of the general assembly of the Commonwealth of Virginia, this report summarizes the surveys for asbestos of all state-owned buildings and all public schools as required by state code. The survey of state-owned buildings was carried out by a consulting firm. Over 5,900 buildings were surveyed, representing approximately 65…

  5. Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.

    PubMed

    Fortuna, Ana; Alves, Gilberto; Soares-da-Silva, Patrício; Falcão, Amílcar

    2013-11-01

    In silico approaches to predict absorption, distribution, metabolism and excretion (ADME) of new drug candidates are gaining a relevant importance in drug discovery programmes. When considering particularly the pharmacokinetics during the development of oral antiepileptic drugs (AEDs), one of the most prominent goals is designing compounds with good bioavailability and brain penetration. Thus, it is expected that in silico models able to predict these features may be applied during the early stages of AEDs discovery. The present investigation was mainly carried out in order to generate in vivo pharmacokinetic data that can be utilized for development and validation of in silico models. For this purpose, a single dose of each compound (1.4mmol/kg) was orally administered to male CD-1 mice. After quantifying the parent compound and main metabolites in plasma and brain up to 12h post-dosing, a non-compartmental pharmacokinetic analysis was performed and the corresponding brain/plasma ratios were calculated. Moreover the plasma protein binding was estimated in vitro applying the ultrafiltration procedure. The present in vivo pharmacokinetic characterization of the test compounds and corresponding metabolites demonstrated that the metabolism extensively compromised the in vivo activity of CBZ derivatives and their toxicity. Furthermore, it was clearly evidenced that the time to reach maximum peak concentration, bioavailability (given by the area under the curve) and metabolic stability (given by the AUC0-12h ratio of the parent compound and total systemic drug) influenced the in vivo pharmacological activities and must be considered as primary parameters to be investigated. All the test compounds presented brain/plasma ratios lower than 1.0, suggesting that the blood-brain barrier restricts drug entry into the brain. In agreement with in vitro studies already performed within our research group, CBZ, CBZ-10,11-epoxide and oxcarbazepine exhibited the highest brain

  6. Models of isospin violating ADM

    SciTech Connect

    Okada, Nobuchika; Seto, Osamu

    2014-06-24

    The isospin violating dark matter (IVDM) scenario offers an interesting possibility to reconcile conflicting results among direct dark matter search experiments for a mass range around 10 GeV. We consider two simple renormalizable IVDM models with a complex scalar dark matter and a Dirac fermion dark matter, respectively, whose stability is ensured by the conservation of “dark matter number.” Although both models successfully work as the IVDM scenario with destructive interference between effective couplings to proton and neutron, the dark matter annihilation cross section is found to exceed the cosmological/astrophysical upper bounds. Then, we propose a simple scenario to reconcile the IVDM scenario with the cosmological/astrophysical bounds, namely, the IVDM being asymmetric. We also discuss collider experimental constraints on the models and an implication to Higgs boson physics.

  7. Team building

    SciTech Connect

    Kane, C.

    1993-04-01

    Power plants are particularly complicated projects with abundant opportunities for disputes. Efforts are beginning in the power industry to change the way the industry does business. Key elements of a comprehensive team-building approach include partnering, constructability, use of incentives, and the disputes review board.

  8. Building Sinusoids

    ERIC Educational Resources Information Center

    Landers, Mara G.

    2013-01-01

    In this article, the author describes the development and implementation of a measurement-based group activity designed to support students in understanding the connection between angle magnitude and the shape of the sine function. She explains that the benefit of this activity is that it allows students to build their trigonometric knowledge…

  9. Laboratory Buildings.

    ERIC Educational Resources Information Center

    Barnett, Jonathan

    The need for flexibility in science research facilities is discussed, with emphasis on the effect of that need on the design of laboratories. The relationship of office space, bench space, and special equipment areas, and the location and distribution of piping and air conditioning, are considered particularly important. This building type study…

  10. Building Trades.

    ERIC Educational Resources Information Center

    Gudzak, Raymond

    This curriculum guide provides materials for a competency-based course in building trades at the secondary level. The curriculum design uses the curriculum infused model for the teaching of basic skills as part of vocational education and demonstrates the relationship of vocationally related skills to communication, mathematics, and science…

  11. Building Community.

    ERIC Educational Resources Information Center

    Schwartz, Edward

    The purpose of this eight-unit course is to explore the values and issues of modern urban neighborhoods. It focuses on how community leaders can apply the broad principle of justice to problems of security, reciprocity, and fellowship that face most neighborhoods today. The course is intended for use by community leaders in building community…

  12. Building Trust.

    ERIC Educational Resources Information Center

    Ambler, Marjane

    1994-01-01

    Describes how an initial $1,500 grant helped build a desperately needed health clinic on the Pine Ridge Reservation. Provides the history of the clinic, from its beginning as a small grant to its ultimate development into a $400,000 solar-heated health clinic with a staff of 9 people, including a full-time physician. (MAB)

  13. 3. EAST AND NORTH SIDES OF BUILDING 314. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. EAST AND NORTH SIDES OF BUILDING 314. VIEW TO SOUTHWEST. - Rocky Mountain Arsenal, Laundry Service Building, 690 feet South of December Seventh Avenue, 60 feet East of D Street, Commerce City, Adams County, CO

  14. 2. SOUTH AND WEST SIDES OF BUILDING 314. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. SOUTH AND WEST SIDES OF BUILDING 314. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Laundry Service Building, 690 feet South of December Seventh Avenue, 60 feet East of D Street, Commerce City, Adams County, CO

  15. 1. WEST AND SOUTH SIDES OF BUILDING 314. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. WEST AND SOUTH SIDES OF BUILDING 314. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Laundry Service Building, 690 feet South of December Seventh Avenue, 60 feet East of D Street, Commerce City, Adams County, CO

  16. View from southwest to northeast of industrial building. Far right ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View from southwest to northeast of industrial building. Far right doors lead to vehicle service and maintenance bays - Stanley R. Mickelsen Safeguard Complex, Industrial Building, One block southwest of Limited Area Sentry Station, Nekoma, Cavalier County, ND

  17. 2. VIEW OF SOUTH AND EAST SIDES OF BUILDING #2300 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF SOUTH AND EAST SIDES OF BUILDING #2300 FACING NORTHWEST. NOTE CURVED KNEE-BRACES ON SUPPORT POSTS. - Medford Service Center, Covered Storage Building, 1319 McAndrews Road, Medford, Jackson County, OR

  18. 21. Perimeter acquisition radar building room #200, electrical equipment room ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Perimeter acquisition radar building room #200, electrical equipment room - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  19. 24. Perimeter acquisition radar building room #203, communications room ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Perimeter acquisition radar building room #203, communications room - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  20. 28. Perimeter acquisition radar building room #302, signal process and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Perimeter acquisition radar building room #302, signal process and analog receiver room - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  1. 30. Perimeter acquisition radar building room #318, showing radar control. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. Perimeter acquisition radar building room #318, showing radar control. Console and line printers - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  2. 32. Perimeter acquisition radar building room #318, closeup of rack ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. Perimeter acquisition radar building room #318, close-up of rack showing logic chassis - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

  3. 4. VIEW LOOKING NORTHWEST OF FUEL HANDLING BUILDING (CENTER), REACTOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING NORTHWEST OF FUEL HANDLING BUILDING (CENTER), REACTOR SERVICE BUILDING (RIGHT), MACHINE SHOP (LEFT) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  4. Building Businesses.

    ERIC Educational Resources Information Center

    Sturgeon, Julie

    2000-01-01

    Discusses how Washington University (St. Louis, MO) converted odd space into a program allowing students to be shopkeepers for necessary services and the school assuming the role of landlord. Tips for overseeing student businesses are highlighted. (GR)

  5. 10 CFR 434.518 - Service water heating.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Service water heating. 434.518 Section 434.518 Energy... RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1The service water loads for Prototype and Reference Buildings are defined in terms of Btu/h per person...

  6. 10 CFR 434.518 - Service water heating.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Service water heating. 434.518 Section 434.518 Energy... RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1The service water loads for Prototype and Reference Buildings are defined in terms of Btu/h per person...

  7. 10 CFR 434.518 - Service water heating.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Service water heating. 434.518 Section 434.518 Energy... RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1 The service water loads for Prototype and Reference Buildings are defined in terms of Btu/h per person...

  8. 10 CFR 434.518 - Service water heating.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Service water heating. 434.518 Section 434.518 Energy... RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1The service water loads for Prototype and Reference Buildings are defined in terms of Btu/h per person...

  9. Library Aides: Building Character, Advancing Service

    ERIC Educational Resources Information Center

    Muronaga, Karen; Masumura, Emmi

    2008-01-01

    Many school library media specialists, especially in elementary schools, establish library clubs and library monitor programs. In most cases, these clubs and programs are limited to students assisting with clerical duties in the library such as shelving books and manning the circulation desk under supervision. The library media specialist assigns…

  10. Building technology services that address student needs.

    PubMed

    Le Ber, Jeanne M; Lombardo, Nancy T; Wimmer, Erin

    2015-01-01

    A 16-question technology use survey was conducted to assess incoming health sciences students' knowledge of and interest in current technologies, and to identify student device and tool preferences. Survey questions were developed by colleagues at a peer institution and then edited to match this library's student population. Two years of student responses have been compiled, compared, and reviewed as a means for informing library decisions related to technology and resource purchases. Instruction and event programming have been revised to meet student preferences. Based on the number of students using Apple products, librarians are addressing the need to become more proficient with this platform. PMID:25611437

  11. Building Buildings with Triangular Numbers

    ERIC Educational Resources Information Center

    Pagni, David L.

    2006-01-01

    Triangular numbers are used to unravel a new sequence of natural numbers here-to-fore not appearing on the Encyclopedia of Integer Sequences website. Insight is provided on the construction of the sequence using "buildings" as a viewable model of the sequence entries. A step-by-step analysis of the sequence pattern reveals a method for generating…

  12. 2. North side of building. View to southeast. U.S. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. North side of building. View to southeast. - U.S. Customs Service Port of Roosville, Immigration & Naturalization Service Residence, 45 feet southwest of Main Port Building, Eureka, Lincoln County, MT

  13. The syntheses of [(14) C]BMS-823778 for use in a human ADME clinical study and of [(13) CD3 (13) CD2 ]BMT-094817, a stable-isotope labeled standard of a newly detected human metabolite.

    PubMed

    Maxwell, Brad D; Tran, Scott B; Lago, Michael; Li, Jun; Bonacorsi, Samuel J

    2016-05-30

    Type 2 diabetes is a significant worldwide health problem. To support the development of BMS-823778 as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 for type 2 diabetes, the synthesis of carbon-14-labeled material was required for use in a human adsorption, distribution, metabolism, and excretion (ADME) study. The HCl salt form of [(14) C]BMS-823778 was synthesized in two steps from commercially available [2-(14) C]acetone. The radiochemical purity of the synthesized [(14) C]BMS-823778 after dilution with unlabeled clinical-grade BMS-823778 was 99.5% having a specific activity of 7.379 μCi/mg. One result of the human ADME study was the detection of a new human metabolite, BMT-094817. To support the quantification of BMT-094817 in clinical samples, it was necessary to synthesize [(13) CD3 (13) CD2 ]BMT-094817 for use as a liquid chromatography/mass spectrometry standard. [(13) CD3 (13) CD2 ]BMT-094817 was prepared in five labeled steps from [(13) CD3 ]iodomethane. PMID:27169762

  14. In vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MS(E) and control comparison: cost and benefit of vehicle-dosed control samples.

    PubMed

    Fiebig, Lukas; Laux, Ralf; Binder, Rudolf; Ebner, Thomas

    2016-10-01

    1. Liquid chromatography (LC)-high resolution mass spectrometry (HRMS) techniques proved to be well suited for the identification of predicted and unexpected drug metabolites in complex biological matrices. 2. To efficiently discriminate between drug-related and endogenous matrix compounds, however, sophisticated postacquisition data mining tools, such as control comparison techniques are needed. For preclinical absorption, distribution, metabolism and excretion (ADME) studies that usually lack a placebo-dosed control group, the question arises how high-quality control data can be yielded using only a minimum number of control animals. 3. In the present study, the combination of LC-traveling wave ion mobility separation (TWIMS)-HRMS(E) and multivariate data analysis was used to study the polymer patterns of the frequently used formulation constituents polyethylene glycol 400 and polysorbate 80 in rat plasma and urine after oral and intravenous administration, respectively. 4. Complex peak patterns of both constituents were identified underlining the general importance of a vehicle-dosed control group in ADME studies for control comparison. Furthermore, the detailed analysis of administration route, blood sampling time and gender influences on both vehicle peak pattern as well as endogenous matrix background revealed that high-quality control data is obtained when (i) control animals receive an intravenous dose of the vehicle, (ii) the blood sampling time point is the same for analyte and control sample and (iii) analyte and control samples of the same gender are compared. PMID:26891802

  15. Osthole shows the potential to overcome P-glycoprotein‑mediated multidrug resistance in human myelogenous leukemia K562/ADM cells by inhibiting the PI3K/Akt signaling pathway.

    PubMed

    Wang, Hong; Jia, Xiu-Hong; Chen, Jie-Ru; Wang, Jian-Yong; Li, You-Jie

    2016-06-01

    P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) has been reported to play a pivotal role in tumor chemotherapy failure. Study after study has illustrated that the phosphoinositide 3-kinase (PI3K)/Akt signaling cascade is involved in the MDR phenotype and is correlated with P-gp expression in many human malignancies. In the present study, osthole, an O-methylated coumarin, exhibited potent reversal capability of MDR in myelogenous leukemia K562/ADM cells. Simultaneously, the uptake and efflux of Rhodamine-123 (Rh-123) and the accumulation of doxorubicin assays combined with flow cytometric analysis suggested that osthole could increase intracellular drug accumulation. Furthermore, osthole decreased the expression of multidrug resistance gene 1 (MDR1) at both the mRNA and protein levels. Further experiments elucidated that osthole could suppress P-gp expression by inhibiting the PI3K/Akt signaling pathway which might be the main mechanism accounting for the reversal potential of osthole in the MDR in K562/ADM cells. In conclusion, osthole combats MDR and could be a promising candidate for the development of novel MDR reversal modulators. PMID:27109742

  16. Inter-Tribal Student Services (I.S.S.): Collaborative Action Education in Building and Guiding the Future Under-represented Geosciences Workforce Through Tribal Foundations, Mentorship and Professional Development.

    NASA Astrophysics Data System (ADS)

    Bolman, J.

    2015-12-01

    Inter-Tribal Student Services (I.S.S.) was created as an Indian Self-Determination Organization to meet the every growing Tribal and under-represented minorities (URM) geosciences workforce needs. I.S.S. is one of only a few Indian Self-Determined Organizations in the U.S. with a distinct focused on buidling the Tribal and URM geosciences and natural resources workforces. In past three years, I.S.S has worked in partnership with U.S. colleges/universities, state/federal agencies (Bureau of Indian Affairs), private and International organizations and most importantly U.S. Tribal Nations to ensure emerging high school students, undergraduates, graduate students and post doctorates have the opportunities for training in supportive and unique environments, navigational mentoring, and broad professional development to build and practice the skills required for blue-collar, scientific, and managerial positions. I.S.S. has been highly successful in filling workforce opportunities within the broad range of geosciences positions. I.S.S. students are proficient in understanding and maneuvering the complex landscapes of interdisciplinary research, multidisciplinary multi-partner projects, traditional/western philosophies as well as being highly proficient in all areas of problem solving and communications. Research and on-site projects have heightened the educational experiences of all participants, in addition to addressing a perplexing geosciences challenge grounded in a Tribal environment. A number of the I.S.S. participants and students have found geosciences positions in Tribes, state/federal agencies, enterprize as well as International organizations. I.S.S. practices and has infused all research and projects with intergenerational teaching/learning, participation solution-focused initiatives, and holistic/multicultural mentoring. The presentation will highlight the vision, design, implementation, outcomes and future directions of I.S.S and participants.

  17. Build an Assistive Technology Toolkit

    ERIC Educational Resources Information Center

    Ahrens, Kelly

    2011-01-01

    Assistive technology (AT) by its very nature consists of a variety of personal and customized tools for multiple learning styles and physical challenges. The author not only encourages students, parents, and educators to advocate for AT services, she also wants them to go a step further and build their own AT toolkits that can instill independence…

  18. Accessing Geospatial Services in Limited Bandwidth Service-Oriented Architecture (SOA) Environments

    ERIC Educational Resources Information Center

    Boggs, James D.

    2013-01-01

    First responders are continuously moving at an incident site and this movement requires them to access Service-Oriented Architecture services, such as a Web Map Service, via mobile wireless networks. First responders from inside a building often have problems in communicating to devices outside that building due to propagation obstacles. Dynamic…

  19. 300 Area Building Retention Evaluation Mitigation Plan

    SciTech Connect

    D. J. McBride

    2007-07-03

    Evaluate the long-term retention of several facilities associated with the PNNL Capability Replacement Laboratory and other Hanfor mission needs. WCH prepared a mitigation plan for three scenarios with different release dates for specific buildings. The evaluations present a proposed plan for providing utility services to retained facilities in support of a long-term (+20 year) lifespan in addition to temporary services to buildings with specified delayed release dates.

  20. 21 CFR 226.20 - Buildings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... Facilities and Equipment § 226.20 Buildings. Buildings in which Type A medicated article(s) are manufactured... minimize risk of mixups between different Type A medicated article(s), their components, packaging,...

  1. 21 CFR 225.20 - Buildings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Buildings. 225.20 Section 225.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Construction and Maintenance of Facilities and Equipment § 225.20 Buildings. (a) The...

  2. The Power of Service Learning

    ERIC Educational Resources Information Center

    Richardson, Scott

    2006-01-01

    When students use classroom skills to build a wheelchair ramp, or teach their peers CPR, or grow vegetables for a food bank, or create children's books for preschoolers, or research and share local history, or educate the community about healthy living, or build and maintain nature trails, they are engaged in service learning (and are called…

  3. Empowering Young People through Service

    ERIC Educational Resources Information Center

    Kapp, Amy

    2009-01-01

    Each year, more than 200 students at YouthBuild Philadelphia Charter School in Pennsylvania make a commitment to help improve Philadelphia's neighborhoods as they work toward their high school diplomas. Since YouthBuild Philadelphia's inception in 1992, students have provided a wide variety of volunteer services to families and organizations…

  4. California commercial building energy benchmarking

    SciTech Connect

    Kinney, Satkartar; Piette, Mary Ann

    2003-07-01

    Building energy benchmarking is the comparison of whole-building energy use relative to a set of similar buildings. It provides a useful starting point for individual energy audits and for targeting buildings for energy-saving measures in multiple-site audits. Benchmarking is of interest and practical use to a number of groups. Energy service companies and performance contractors communicate energy savings potential with ''typical'' and ''best-practice'' benchmarks while control companies and utilities can provide direct tracking of energy use and combine data from multiple buildings. Benchmarking is also useful in the design stage of a new building or retrofit to determine if a design is relatively efficient. Energy managers and building owners have an ongoing interest in comparing energy performance to others. Large corporations, schools, and government agencies with numerous facilities also use benchmarking methods to compare their buildings to each other. The primary goal of Task 2.1.1 Web-based Benchmarking was the development of a web-based benchmarking tool, dubbed Cal-Arch, for benchmarking energy use in California commercial buildings. While there were several other benchmarking tools available to California consumers prior to the development of Cal-Arch, there were none that were based solely on California data. Most available benchmarking information, including the Energy Star performance rating, were developed using DOE's Commercial Building Energy Consumption Survey (CBECS), which does not provide state-level data. Each database and tool has advantages as well as limitations, such as the number of buildings and the coverage by type, climate regions and end uses. There is considerable commercial interest in benchmarking because it provides an inexpensive method of screening buildings for tune-ups and retrofits. However, private companies who collect and manage consumption data are concerned that the identities of building owners might be revealed and

  5. 2. View northwest of main hospital building complex, hospital building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. View northwest of main hospital building complex, hospital building (Building 90), administration and clinical hospital building (Building 88), and hospital building (Building 91) - National Home for Disabled Volunteer Soldiers Western Branch, 4101 South Fourth Street, Leavenworth, Leavenworth County, KS

  6. Modernizing Mechanical Services.

    ERIC Educational Resources Information Center

    Rutgers, Norman L.

    Some of the problems of renovating school buildings and in particular the modernization of mechanical services in existing facilities are discussed. According to school management publications, approximately 42 per cent of our elementary and 59 per cent of our secondary schools are 15 years old or older. School plants, which were built 12 to 15…

  7. Improving: Services for Children

    ERIC Educational Resources Information Center

    Her Majesty's Inspectorate of Education, 2008

    2008-01-01

    This guide to self-evaluation and improvement builds upon the advice given in the publication "A Guide to Evaluating Services for Children and Young People Using Quality Indicators" (HMIE, 2006) (A summary of the quality indicators is reproduced in Appendix I). Local authorities, agencies and professionals who have responsibilities for providing…

  8. Smart Buildings and Demand Response

    NASA Astrophysics Data System (ADS)

    Kiliccote, Sila; Piette, Mary Ann; Ghatikar, Girish

    2011-11-01

    Advances in communications and control technology, the strengthening of the Internet, and the growing appreciation of the urgency to reduce demand side energy use are motivating the development of improvements in both energy efficiency and demand response (DR) systems in buildings. This paper provides a framework linking continuous energy management and continuous communications for automated demand response (Auto-DR) in various times scales. We provide a set of concepts for monitoring and controls linked to standards and procedures such as Open Automation Demand Response Communication Standards (OpenADR). Basic building energy science and control issues in this approach begin with key building components, systems, end-uses and whole building energy performance metrics. The paper presents a framework about when energy is used, levels of services by energy using systems, granularity of control, and speed of telemetry. DR, when defined as a discrete event, requires a different set of building service levels than daily operations. We provide examples of lessons from DR case studies and links to energy efficiency.

  9. Commercial Buildings Energy Consumption Survey - Office Buildings

    EIA Publications

    2010-01-01

    Provides an in-depth look at this building type as reported in the 2003 Commercial Buildings Energy Consumption Survey. Office buildings are the most common type of commercial building and they consumed more than 17% of all energy in the commercial buildings sector in 2003. This special report provides characteristics and energy consumption data by type of office building (e.g. administrative office, government office, medical office) and information on some of the types of equipment found in office buildings: heating and cooling equipment, computers, servers, printers, and photocopiers.

  10. The Mind-Body Building Equation.

    ERIC Educational Resources Information Center

    Dryfoos, Joy

    2000-01-01

    Full-service community schools combine three concepts--mind, body, and building--into an integrated approach placing quality education and comprehensive support services at one site. The DeWitt Wallace-Reader's Digest Fund is helping schools and communities replicate 4 such programs at 60 sites in 20 U.S. cities. (MLH)

  11. Clinical outcomes, survivorship and adverse events with mobile-bearings versus fixed-bearings in hip arthroplasty-a prospective comparative cohort study of 143 ADM versus 130 trident cups at 2 to 6-year follow-up.

    PubMed

    Epinette, Jean-Alain

    2015-02-01

    The principle of dual mobility cups, often called "tripolar", has been developed to overcome the problem of instability following primary hip arthroplasty. We prospectively compared two cohorts which differed only by the type of bearings, i.e." mobile bearing hip" (MBH) in a 143-study cohort of ADM cups versus "fixed bearing hip" (FBH) of 130 Trident PSL cups, at a follow-up at 2-6years. The survival rates at 4.13-years, with instability as endpoint was significantly (P=0.0176) in favor of mobile bearings at 100% with no dislocation reported, versus 94.8% with fixed bearings. These mobile bearings, matching both "modern" dual mobility cups and annealed highly crossed polyethylene, would appear to offer at longer follow-up a valuable solution to clinical outcomes in acetabular arthroplasty. PMID:25449593

  12. Dissemination Capacity Building in an SDE. [State Department of Education].

    ERIC Educational Resources Information Center

    Goddu, Roland

    Capacity building for dissemination in a State requires the development of a completely responsive linkage system. The State Department of Education (SDE) capacity building effort should focus on people delivering kinds of service, not kinds of information. The service will depend on ready and immediate access to information, but the humanizing…

  13. Building energy analysis tool

    DOEpatents

    Brackney, Larry; Parker, Andrew; Long, Nicholas; Metzger, Ian; Dean, Jesse; Lisell, Lars

    2016-04-12

    A building energy analysis system includes a building component library configured to store a plurality of building components, a modeling tool configured to access the building component library and create a building model of a building under analysis using building spatial data and using selected building components of the plurality of building components stored in the building component library, a building analysis engine configured to operate the building model and generate a baseline energy model of the building under analysis and further configured to apply one or more energy conservation measures to the baseline energy model in order to generate one or more corresponding optimized energy models, and a recommendation tool configured to assess the one or more optimized energy models against the baseline energy model and generate recommendations for substitute building components or modifications.

  14. EXTERIOR VIEW, FRONT (NORTH) ELEVATION. THIS THREESTORY BRICK BUILDING WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR VIEW, FRONT (NORTH) ELEVATION. THIS THREE-STORY BRICK BUILDING WITH DEEPLY-BRACKETED AND OVERHANGING EAVES INCLUDES MULTIPLE BAYS CONSTRUCTED BEGINNING IN 1913 TO SERVE AS A 'CIVIC CENTER' FOR ACIPCO EMPLOYEES AND THEIR FAMILIES. THE BUILDING CURRENTLY INCLUDES THE TIME OFFICE, CAFETERIA, AND AUDITORIUM. - American Cast Iron Pipe Company, Service Building, 1501 Thirty-first Avenue North, Birmingham, Jefferson County, AL

  15. YouthBuild. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2009

    2009-01-01

    "YouthBuild" offers low-income youth both education and job training services. "YouthBuild's" education component emphasizes attaining a GED or high school diploma, typically in alternative schools with small class sizes and an emphasis on individualized instruction. In "YouthBuild's" job-training program, participants work in construction jobs…

  16. 47 CFR 32.6121 - Land and building expense.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Land and building expense. 32.6121 Section 32.6121 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM... building expense. (a) This account shall include expenses associated with land and buildings...

  17. Fire in High Buildings. Fire Study No. 21.

    ERIC Educational Resources Information Center

    Galbreath, M.

    Research into and measures of fire protection with regard to high building design are discussed with suggestions for proper building equipment, materials, and planning. The study outlines how smoke and toxic gases spread in high buildings through stairs, service shafts, air handling and heating equipment. The problems of basement fires, means of…

  18. The EMBRACE web service collection

    PubMed Central

    Pettifer, Steve; Ison, Jon; Kalaš, Matúš; Thorne, Dave; McDermott, Philip; Jonassen, Inge; Liaquat, Ali; Fernández, José M.; Rodriguez, Jose M.; Partners, INB-; Pisano, David G.; Blanchet, Christophe; Uludag, Mahmut; Rice, Peter; Bartaseviciute, Edita; Rapacki, Kristoffer; Hekkelman, Maarten; Sand, Olivier; Stockinger, Heinz; Clegg, Andrew B.; Bongcam-Rudloff, Erik; Salzemann, Jean; Breton, Vincent; Attwood, Teresa K.; Cameron, Graham; Vriend, Gert

    2010-01-01

    The EMBRACE (European Model for Bioinformatics Research and Community Education) web service collection is the culmination of a 5-year project that set out to investigate issues involved in developing and deploying web services for use in the life sciences. The project concluded that in order for web services to achieve widespread adoption, standards must be defined for the choice of web service technology, for semantically annotating both service function and the data exchanged, and a mechanism for discovering services must be provided. Building on this, the project developed: EDAM, an ontology for describing life science web services; BioXSD, a schema for exchanging data between services; and a centralized registry (http://www.embraceregistry.net) that collects together around 1000 services developed by the consortium partners. This article presents the current status of the collection and its associated recommendations and standards definitions. PMID:20462862

  19. 14. A westward view of building #5 in the background, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. A westward view of building #5 in the background, low buildings #22 and #23 in the center and supports for the water tower. The roadway was previously rail service to buildings #3, #5, and #9. The trackage had been mostly covered with fill, representing the transition from rail to truck service. The two enclosed passageways to the left of center carried semi-processed tire chain from building #9, on the left, to buildings #3 and #5. - American Chain & Cable Company, East Princess Street (400 Block), York, York County, PA

  20. Building America

    SciTech Connect

    Brad Oberg

    2010-12-31

    Builders generally use a 'spec and purchase' business management system (BMS) when implementing energy efficiency. A BMS is the overall operational and organizational systems and strategies that a builder uses to set up and run its company. This type of BMS treats building performance as a simple technology swap (e.g. a tank water heater to a tankless water heater) and typically compartmentalizes energy efficiency within one or two groups in the organization (e.g. purchasing and construction). While certain tools, such as details, checklists, and scopes of work, can assist builders in managing the quality of the construction of higher performance homes, they do nothing to address the underlying operational strategies and issues related to change management that builders face when they make high performance homes a core part of their mission. To achieve the systems integration necessary for attaining 40% + levels of energy efficiency, while capturing the cost tradeoffs, builders must use a 'systems approach' BMS, rather than a 'spec and purchase' BMS. The following attributes are inherent in a systems approach BMS; they are also generally seen in quality management systems (QMS), such as the National Housing Quality Certification program: Cultural and corporate alignment, Clear intent for quality and performance, Increased collaboration across internal and external teams, Better communication practices and systems, Disciplined approach to quality control, Measurement and verification of performance, Continuous feedback and improvement, and Whole house integrated design and specification.

  1. Innovation in Management of Primary School Construction: Multi-Purpose Primary School Buildings in Bangladesh. Educational Building Report 18.

    ERIC Educational Resources Information Center

    Constantinos, Fecadu

    This report deals with school building construction utilizing technology carried out by the Lutheran World Service/Rangpur Dinajpur Rehabilitation Service in Bangladesh. The purpose was to develop an alternative design for primary school constructions. The design, construction, and multipurpose use of the school buildings are described. Appended…

  2. H.R.3637 — 112th Congress (2011-2012) To designate the facility of the United States Postal Service located at 401 Old Dixie Highway in Jupiter, Florida, as the "Roy Schallern Rood Post Office Building".

    THOMAS, 112th Congress

    Rep. Rooney, Thomas J. [R-FL-16

    2011-12-12

    03/14/2012 Committee on Homeland Security and Governmental Affairs referred to Subcommittee on Federal Financial Management, Government Information, Federal Services, and International Security. (All Actions)

  3. S.3435 — 112th Congress (2011-2012) A bill to designate the facility of the United States Postal Service located at 26 East Genesee Street in Baldwinsville, New York, as the "Corporal Kyle Schneider Post Office Building".

    THOMAS, 112th Congress

    Sen. Gillibrand, Kirsten E. [D-NY

    2012-07-25

    08/29/2012 Committee on Homeland Security and Governmental Affairs referred to Subcommittee on Federal Financial Management, Government Information, Federal Services, and International Security. (All Actions)

  4. H.R.2548 — 112th Congress (2011-2012) To designate the facility of the United States Postal Service located at 6310 North University Street in Peoria, Illinois, as the "Charles 'Chip' Lawrence Chan Post Office Building".

    THOMAS, 112th Congress

    Rep. Schock, Aaron [R-IL-18

    2011-07-14

    08/18/2011 Committee on Homeland Security and Governmental Affairs referred to Subcommittee on Federal Financial Management, Government Information, Federal Services, and International Security. (All Actions)

  5. 29 CFR 779.335 - Sales of building materials for residential or farm building construction.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Sales of building materials for residential or farm building construction. 779.335 Section 779.335 Labor Regulations Relating to Labor (Continued) WAGE AND... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of...

  6. 29 CFR 779.335 - Sales of building materials for residential or farm building construction.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Sales of building materials for residential or farm building construction. 779.335 Section 779.335 Labor Regulations Relating to Labor (Continued) WAGE AND... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of...

  7. 29 CFR 779.335 - Sales of building materials for residential or farm building construction.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Sales of building materials for residential or farm building construction. 779.335 Section 779.335 Labor Regulations Relating to Labor (Continued) WAGE AND... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of...

  8. 29 CFR 779.335 - Sales of building materials for residential or farm building construction.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Sales of building materials for residential or farm building construction. 779.335 Section 779.335 Labor Regulations Relating to Labor (Continued) WAGE AND... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of...

  9. 29 CFR 779.335 - Sales of building materials for residential or farm building construction.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Sales of building materials for residential or farm building construction. 779.335 Section 779.335 Labor Regulations Relating to Labor (Continued) WAGE AND... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of...

  10. 76 FR 52335 - National Advisory Committee on Rural Health and Human Services; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... HUMAN SERVICES Health Resources and Services Administration National Advisory Committee on Rural Health... on Rural Health and Human Services, Health Resources and Services Administration, Parklawn Building... recommendations to the Secretary with respect to the delivery, research, development, and administration of...

  11. Partnering for Quality under the Workforce Investment Act: A Tool Kit for One-Stop System Building. Module 4: Designing a System for the Delivery of Integrated Services. Trainer Manual with Participant Workbook.

    ERIC Educational Resources Information Center

    Kogan, Deborah; Koller, Vinz; Kozumplik, Richalene; Lawrence, Mary Ann

    This document is part of a five-module training package to help employment and training service providers comply with the Workforce Investment Act (WIA) of 1998 and develop a one-stop training and employment services system. It consists of the participant workbook, trainer manual, and activity worksheets for a module on designing a system for the…

  12. BUILDING 341 Seismic Evaluation

    SciTech Connect

    Halle, J.

    2015-06-15

    The Seismic Evaluation of Building 341 located at Lawrence Livermore National Laboratory in Livermore, California has been completed. The subject building consists of a main building, Increment 1, and two smaller additions; Increments 2 and 3.

  13. 49 CFR 192.375 - Service lines: Plastic.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the...

  14. 49 CFR 192.375 - Service lines: Plastic.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the...

  15. 49 CFR 192.375 - Service lines: Plastic.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the...

  16. 49 CFR 192.375 - Service lines: Plastic.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the...

  17. 49 CFR 192.375 - Service lines: Plastic.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the...

  18. Facility Focus: Science Buildings.

    ERIC Educational Resources Information Center

    College Planning & Management, 1999

    1999-01-01

    Provides examples of four university science buildings whose design fosters interdisciplinary interaction among students coupled with lab flexibility. Design concepts, innovations, and building layouts are examined. (GR)

  19. Programmability and service creation for multimedia networks

    SciTech Connect

    Lazar, A.A.; Lim, Koon-Seng

    1996-12-31

    The Binding Architecture is an open architecture for building multimedia networks that must guarantee Quality of Service (QOS). In this paper, we explore the notion of a service in the Binding Architecture and propose a conceptual model for building scalable multimedia distribution services based on it. We begin first by examining the relation between resources, their abstractions and the services that can be built from them and use this to derive a general model for binding. Based on this model, we identify a general set of capabilities required for building any multimedia distribution service. We also describe how these capabilities can be incorporated into our view of the service creation process. Finally, we augment our discussion with the description of an example service which we have developed using this paradigm.

  20. Solar buildings. Overview: The Solar Buildings Program

    SciTech Connect

    Not Available

    1998-04-01

    Buildings account for more than one third of the energy used in the United States each year, consuming vast amounts of electricity, natural gas, and fuel oil. Given this level of consumption, the buildings sector is rife with opportunity for alternative energy technologies. The US Department of Energy`s Solar Buildings Program was established to take advantage of this opportunity. The Solar Buildings Program is engaged in research, development, and deployment on solar thermal technologies, which use solar energy to produce heat. The Program focuses on technologies that have the potential to produce economically competitive energy for the buildings sector.

  1. Solar buildings. Overview: The Solar Buildings Program

    SciTech Connect

    1998-04-01

    Buildings account for more than one third of the energy used in the United States each year, consuming vast amounts of electricity, natural gas, and fuel oil. Given this level of consumption, the buildings sector is rife with opportunity for alternative energy technologies. The US Department of Energy's Solar Buildings Program was established to take advantage of this opportunity. The Solar Buildings Program is engaged in research, development, and deployment on solar thermal technologies, which use solar energy to produce heat. The Program focuses on technologies that have the potential to produce economically competitive energy for the buildings sector.

  2. Building Multidisciplinary Training Networks for Rural Development. Report of the Regional Workshop for Pre-service Training of Members of Multidisciplinary Educational Teams in Rural Areas (Pune, India, July 16-20, 1985).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and Oceania.

    Papers designed to help build multidisciplinary training networks for rural development are collected in this document, an outgrowth of a regional training workshop attended by participants from Bangladesh, Nepal, Pakistan, Philippines, Republic of Korea, Thailand, and India. The six papers deal with the objectives of the workshop which were to:…

  3. In-Service Training for Instructors Designed to Build the Necessary Skills Needed to Plan, Develop, and Implement Competency-Based Vocational Education. Final Report (July 1, 1980-June 30, 1981).

    ERIC Educational Resources Information Center

    Epler, Doris M.

    This project extended two previous projects which were designed to assist teachers in building the necessary skills to plan, develop, and implement competency-based vocational education (CBVE). In addition to released time for instructors, the project provided the funds necessary to form an articulation team effort among Pennsylvania's Reading…

  4. IFLA General Conference, 1992. Division of Management and Technology: Audiovisual Media (RT); Section on Library Services to Multicultural Populations; Section on Library Buildings and Equipment; Section on Information Technology; Management of Library Associations (RT); Section on Statistics. Papers

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, London (England).

    Eleven papers delivered at the annual meeting of the International Federation of Library Associations and Institutions for the Division of Management and Technology are presented. Some were presented at a roundtable on audiovisual media, and others are from sessions on library buildings and equipment, information management, and statistics in…

  5. PROJECTION OF THOUGHTS AND IDEAS ON SCHOOL BUILDINGS OF TOMORROW--A SPEECH GIVEN TO THE 1ST ANNUAL SCHOOL ADMINISTRATORS SEMINAR OF THE AMERICAN SCHOOL FOOD SERVICE ASSOCIATION (VAIL VILLAGE, COLORADO, DEC. 6-8, 1967). (TITLE SUPPLIED).

    ERIC Educational Resources Information Center

    BURR, DONALD F.

    THE SPEECH RECOUNTS THE NEW DIRECTION IN THE FLEXIBLE DESIGN OF FUTURE PUBLIC SCHOOLS. IT IS PREDICTED THAT WITHIN THE NEXT SEVERAL DECADES A MULTITUDE OF NEW SCHOOL BUILDINGS WILL BE CONSTRUCTED IN ADDITION TO THE REPLACEMENT OF EXISTING SCHOOL PLANTS AS THEY BECOME OUTDATED AND INADEQUATE FOR NEW INSTRUCTIONAL PROGRAMS. THE NEW INSTRUCTIONAL…

  6. Service-Learning and LIS Education.

    ERIC Educational Resources Information Center

    Yontz, Elaine; McCook, Kathleen de la Pena

    2003-01-01

    Discusses service learning in library and information science (LIS) education. Highlights include advantages of service learning, including increased student learning, extended collaboration, decreased isolation, and community building; examples of service learning projects, including fieldwork; and reflection as a component in fieldwork.…

  7. Alabama Public Library Service 1996 Annual Report.

    ERIC Educational Resources Information Center

    Alabama Public Library Service, Montgomery.

    The Alabama Public Library Service is charged with improving library services throughout Alabama to ensure that all citizens have access to quality library and information services. The agency is responsible for administering federal and state funds for the more than 200 public libraries in Alabama. Building renovations were completed in April…

  8. Smart Buildings: Business Case and Action Plan

    SciTech Connect

    Ehrlich, Paul; Diamond, Rick

    2009-04-01

    General Services Administration (GSA) has been a pioneer in using Smart Building technologies but it has yet to achieve the full benefits of an integrated, enterprise-wide Smart Building strategy. In July 2008, GSA developed an initial briefing memorandum that identified five actions for a Smart Buildings feasibility study: (1) Identify and cluster the major building systems under consideration for a Smart Buildings initiative; (2) Identify GSA priorities for these clusters; (3) Plan for future adoption of Smart Building strategies by identifying compatible hardware; (4) Develop a framework for implementing and testing Smart Building strategies and converged networks; and (5) Document relevant GSA and industry initiatives in this arena. Based on this briefing memorandum, PBS and FAS retained consultants from Lawrence Berkeley National Laboratory, Noblis, and the Building Intelligence Group to evaluate the potential for Smart Buildings within GSA, and to develop this report. The project has included extensive interviews with GSA staff (See Appendix A), a review of existing GSA standards and documents, and an examination of relevant GSA and industry initiatives. Based on interviews with GSA staff and a review of GSA standards and documents, the project team focused on four goals for evaluating how Smart Building technology can benefit GSA: (1) Achieve Energy Efficiency Mandates--Use Smart Building technology as a tool to meet EISA 2007 and EO 13423 goals for energy efficiency. (2) Enhance Property Management--Deploy enterprise tools for improved Operations and Maintenance (O&M) performance and verification. (3) Implement Network as the Fourth Utility--Utilize a converged broadband network to support Smart Building systems and provide GSA clients with connectivity for voice, data and video. (4) Enhance Safety and Security--Harmonize Physical Access Control Systems (PACS) with Smart Building Systems.

  9. Telerehabilitation: An Adjunct Service Delivery Model For Early Intervention Services

    PubMed Central

    Cason, Jana

    2011-01-01

    Early Intervention (EI) services for children birth through two years of age are mandated by Part C of the Individuals with Disabilities Education Act (IDEA); however, personnel shortages, particularly in rural areas, limit access for children who qualify. Telerehabilitation has the potential to build capacity among caregivers and local providers as well as promote family-centered services through remote consultation. This article provides an overview of research related to telerehabilitation and early intervention services; discusses the feasibility of telerehabilitation within traditional EI service delivery models; examines telecommunications technology associated with telerehabilitation; and provides hypothetical case examples designed to illustrate potential applications of telerehabilitation in early intervention. PMID:25945179

  10. Wynkoop Building Performance Measurement: Water

    SciTech Connect

    Fowler, Kimberly M.; Kora, Angela R.

    2012-08-26

    This report is a summary of the water analysis performance for the Denver, Colorado Wynkoop Building. The Wynkoop Building (Figure 1) was built in 2006 as the Environmental Protection Agency (EPA) Region 8 Headquarters intended to house over 900 occupants in the 301,292 gross square feet (248,849 rentable square feet). The building was built on a brownfield in the Lower Downtown Historic District as part of an urban redevelopment effort. The building was designed and constructed through a public-private partnership with the sustainable design elements developed jointly by General Services Administration (GSA) and EPA. That partnership is still active with all parties still engaged to optimize building operations and use the building as a Learning Laboratory. The building design achieved U.S. Green Building Council Leadership in Energy and Environmental Design for New Construction (LEED-NC) Gold Certification in 2008 (Figure 2) and a 2008 EPA Energy Star Rating of 96 with design highlights that include: (1) Water use was designed to use 40% less than a typical design baseline. The design included low flow fixtures, waterless urinals and dual flush toilets; (2) Native and adaptive vegetation were selected to minimize the need for irrigation water for landscaping; and (3) Energy use intensity was modeled at 66.1 kBtus/gross square foot, which is 39% better than ASHRAE 90.1 1999. The Wynkoop Building water use (10 gallons/square foot) was measured at lower than industry average (15 gallons/square foot) and GSA goals (13 gallons/square foot), however, it was higher than building management expected it would be. The type of occupants and number of occupants can have a significant impact on fixture water use. The occupancy per floor varied significantly over the study time period, which added uncertainty to the data analysis. Investigation of the fixture use on the 2nd, 5th, and 7th floors identified potential for water use reduction if the flush direction of the dual

  11. Modular Buildings Buying Guide.

    ERIC Educational Resources Information Center

    Morris, Susan

    1991-01-01

    Suggests that child care program directors who are expanding their programs or opening new child care centers investigate the possibility of renting, leasing, or purchasing a modular building. Discusses the advantages of modular buildings over conventional building construction or rented space in an occupied building. Provides information about…

  12. Building-to-Grid Integration through Commercial Building Portfolios Participating in Energy and Frequency Regulation Markets

    NASA Astrophysics Data System (ADS)

    Pavlak, Gregory S.

    Building energy use is a significant contributing factor to growing worldwide energy demands. In pursuit of a sustainable energy future, commercial building operations must be intelligently integrated with the electric system to increase efficiency and enable renewable generation. Toward this end, a model-based methodology was developed to estimate the capability of commercial buildings to participate in frequency regulation ancillary service markets. This methodology was integrated into a supervisory model predictive controller to optimize building operation in consideration of energy prices, demand charges, and ancillary service revenue. The supervisory control problem was extended to building portfolios to evaluate opportunities for synergistic effect among multiple, centrally-optimized buildings. Simulation studies performed showed that the multi-market optimization was able to determine appropriate opportunities for buildings to provide frequency regulation. Total savings were increased by up to thirteen percentage points, depending on the simulation case. Furthermore, optimizing buildings as a portfolio achieved up to seven additional percentage points of savings, depending on the case. Enhanced energy and cost savings opportunities were observed by taking the novel perspective of optimizing building portfolios in multiple grid markets, motivating future pursuits of advanced control paradigms that enable a more intelligent electric grid.

  13. Reference Services.

    ERIC Educational Resources Information Center

    Bunge, Charles A.

    1999-01-01

    Discusses library reference services. Topics include the historical development of reference services; instruction in library use, particularly in college and university libraries; guidance; information and referral services and how they differ from traditional question-answering service; and future concerns, including user fees and the planning…

  14. Safety analysis report 231-Z Building

    SciTech Connect

    Powers, C.S.

    1989-03-01

    This report provides an intensive review of the nuclear safety of the operation of the 231-Z Building. For background information complete descriptions of the floor plan, building services, alarm systems, and glove box systems are included in this report. In addition, references are included to The Plutonium Laboratory Radiation Work Procedures, Safety Guides, 231-Z Operating Procedures Manual and Nuclear Materials accountability Procedures. Engineered and administrative features contribute to the overall safety of personnel, the building, and environs. The consequences of credible incidents were considered and are discussed.

  15. 15 CFR 950.8 - Satellite Data Services Division (SDSD).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...., weather forecasting) have been satisfied. The division also provides photographs collected during NASA's... to: Satellite Data Services Division, World Weather Building, Room 606, Washington, DC 20233,...

  16. 15 CFR 950.8 - Satellite Data Services Division (SDSD).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...., weather forecasting) have been satisfied. The division also provides photographs collected during NASA's... to: Satellite Data Services Division, World Weather Building, Room 606, Washington, DC 20233,...

  17. 15 CFR 950.8 - Satellite Data Services Division (SDSD).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...., weather forecasting) have been satisfied. The division also provides photographs collected during NASA's... to: Satellite Data Services Division, World Weather Building, Room 606, Washington, DC 20233,...

  18. 15 CFR 950.8 - Satellite Data Services Division (SDSD).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...., weather forecasting) have been satisfied. The division also provides photographs collected during NASA's... to: Satellite Data Services Division, World Weather Building, Room 606, Washington, DC 20233,...

  19. 15 CFR 950.8 - Satellite Data Services Division (SDSD).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...., weather forecasting) have been satisfied. The division also provides photographs collected during NASA's... to: Satellite Data Services Division, World Weather Building, Room 606, Washington, DC 20233,...

  20. 5. VIEW FROM SLIGHTLY FARTHER DOWN SERVICE ROAD, LOOKING SOUTHEAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW FROM SLIGHTLY FARTHER DOWN SERVICE ROAD, LOOKING SOUTHEAST AT ELECTRICITY SUPPLY BUILDING, LABORATORY, AND OFFICE. - Standard Lime & Stone Quarry, County Route 27, Millville, Jefferson County, WV