Deletion of admB gene encoding a fungal ADAM affects cell wall construction in Aspergillus oryzae.

PubMed

Kobayashi, Takuji; Maeda, Hiroshi; Takeuchi, Michio; Yamagata, Youhei

2017-05-01

Mammals possess a unique signaling system based on the proteolytic mechanism of a disintegrin and metalloproteinases (ADAMs) on the cell surface. We found two genes encoding ADAMs in Aspergillus oryzae and named them admA and admB. We produced admA and admB deletion strains to elucidate their biological function and clarify whether fungal ADAMs play a similar role as in mammals. The ∆admA∆admB and ∆admB strains were sensitive to cell wall-perturbing agents, congo red, and calcofluor white. Moreover, the two strains showed significantly increased weights of total alkali-soluble fractions from the mycelial cell wall compared to the control strain. Furthermore, ∆admB showed MpkA phosphorylation at lower concentration of congo red stimulation than the control strain. However, the MpkA phosphorylation level was not different between ∆admB and the control strain without the stimulation. The results indicated that A. oryzae AdmB involved in the cell wall integrity without going through the MpkA pathway.

ADM For Solving Linear Second-Order Fredholm Integro-Differential Equations

NASA Astrophysics Data System (ADS)

Karim, Mohd F.; Mohamad, Mahathir; Saifullah Rusiman, Mohd; Che-Him, Norziha; Roslan, Rozaini; Khalid, Kamil

2018-04-01

In this paper, we apply Adomian Decomposition Method (ADM) as numerically analyse linear second-order Fredholm Integro-differential Equations. The approximate solutions of the problems are calculated by Maple package. Some numerical examples have been considered to illustrate the ADM for solving this equation. The results are compared with the existing exact solution. Thus, the Adomian decomposition method can be the best alternative method for solving linear second-order Fredholm Integro-Differential equation. It converges to the exact solution quickly and in the same time reduces computational work for solving the equation. The result obtained by ADM shows the ability and efficiency for solving these equations.

Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis.

PubMed

Caironi, Pietro; Latini, Roberto; Struck, Joachim; Hartmann, Oliver; Bergmann, Andreas; Maggio, Giuseppe; Cavana, Marco; Tognoni, Gianni; Pesenti, Antonio; Gattinoni, Luciano; Masson, Serge

2017-08-01

The biological role of adrenomedullin (ADM), a hormone involved in hemodynamic homeostasis, is controversial in sepsis because administration of either the peptide or an antibody against it may be beneficial. Plasma biologically active ADM (bio-ADM) was assessed on days 1, 2, and 7 after randomization of 956 patients with sepsis or septic shock to albumin or crystalloids for fluid resuscitation in the multicenter Albumin Italian Outcome Sepsis trial. We tested the association of bio-ADM and its time-dependent variation with fluid therapy, vasopressor administration, organ failures, and mortality. Plasma bio-ADM on day 1 (median [Q1-Q3], 110 [59-198] pg/mL) was higher in patients with septic shock, associated with 90-day mortality, multiple organ failures and the average extent of hemodynamic support therapy (fluids and vasopressors), and serum lactate time course over the first week. Moreover, it predicted incident cardiovascular dysfunction in patients without shock at enrollment (OR [95% CI], 1.9 [1.4-2.5]; P < .0001, for an increase of 1 interquartile range of bio-ADM concentration). bio-ADM trajectory during the first week of treatment clearly predicted 90-day mortality after adjustment for clinically relevant covariates (hazard ratio [95% CI], 1.3 [1.2-1.4]; P < .0001), and its reduction below 110 pg/mL at day 7 was associated with a marked reduction in 90-day mortality. Changes over the first 7 days of bio-ADM concentrations were not dependent on albumin treatment. In patients with sepsis, the circulating, biologically active form of ADM may help individualizing hemodynamic support therapy, while avoiding harmful effects. Its possible pathophysiologic role makes bio-ADM a potential candidate for future targeted therapies. ClinicalTrials.gov; No.: NCT00707122. Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets.

PubMed

Clark, Alex M; Dole, Krishna; Coulon-Spektor, Anna; McNutt, Andrew; Grass, George; Freundlich, Joel S; Reynolds, Robert C; Ekins, Sean

2015-06-22

On the order of hundreds of absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) models have been described in the literature in the past decade which are more often than not inaccessible to anyone but their authors. Public accessibility is also an issue with computational models for bioactivity, and the ability to share such models still remains a major challenge limiting drug discovery. We describe the creation of a reference implementation of a Bayesian model-building software module, which we have released as an open source component that is now included in the Chemistry Development Kit (CDK) project, as well as implemented in the CDD Vault and in several mobile apps. We use this implementation to build an array of Bayesian models for ADME/Tox, in vitro and in vivo bioactivity, and other physicochemical properties. We show that these models possess cross-validation receiver operator curve values comparable to those generated previously in prior publications using alternative tools. We have now described how the implementation of Bayesian models with FCFP6 descriptors generated in the CDD Vault enables the rapid production of robust machine learning models from public data or the user's own datasets. The current study sets the stage for generating models in proprietary software (such as CDD) and exporting these models in a format that could be run in open source software using CDK components. This work also demonstrates that we can enable biocomputation across distributed private or public datasets to enhance drug discovery.

Conference report: a hitchhiker's guide to outsourcing ADME studies: the inside of outsourcing.

PubMed

Pritchard, J Fred; Anderson, Shelby R; Breuckner, Claudia; Premkumar, Noel D; Polli, Joseph W

2013-02-01

This report gives a summary of the key points raised during a roundtable discussion convened at the American Association of Pharmaceutical Scientists 2012 Annual Meeting and Exposition held in Chicago on 17 October 2012. The science of ADME continues to grow, as does the impact of these studies on drug development. Understanding ADME requires efforts from several scientific specialties. With reductions in pharmaceutical company R&D staff there has been a corresponding growth in CROs with the capabilities and expertise to perform ADME work. This roundtable explored the challenges inherent in understanding ADME and the issues that arise when ADME studies shift from in-house study directors to external scientists working within the business model of a CRO. Pharmaceutical industry scientists and procurement specialists can satisfy their expectations by awareness of the growing expertise within CROs and the need for open communication among all partners involved in outsourced work.

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

PubMed Central

2015-01-01

On the order of hundreds of absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) models have been described in the literature in the past decade which are more often than not inaccessible to anyone but their authors. Public accessibility is also an issue with computational models for bioactivity, and the ability to share such models still remains a major challenge limiting drug discovery. We describe the creation of a reference implementation of a Bayesian model-building software module, which we have released as an open source component that is now included in the Chemistry Development Kit (CDK) project, as well as implemented in the CDD Vault and in several mobile apps. We use this implementation to build an array of Bayesian models for ADME/Tox, in vitro and in vivo bioactivity, and other physicochemical properties. We show that these models possess cross-validation receiver operator curve values comparable to those generated previously in prior publications using alternative tools. We have now described how the implementation of Bayesian models with FCFP6 descriptors generated in the CDD Vault enables the rapid production of robust machine learning models from public data or the user’s own datasets. The current study sets the stage for generating models in proprietary software (such as CDD) and exporting these models in a format that could be run in open source software using CDK components. This work also demonstrates that we can enable biocomputation across distributed private or public datasets to enhance drug discovery. PMID:25994950

Implementing ADM1 for plant-wide benchmark simulations in Matlab/Simulink.

PubMed

Rosen, C; Vrecko, D; Gernaey, K V; Pons, M N; Jeppsson, U

2006-01-01

The IWA Anaerobic Digestion Model No.1 (ADM1) was presented in 2002 and is expected to represent the state-of-the-art model within this field in the future. Due to its complexity the implementation of the model is not a simple task and several computational aspects need to be considered, in particular if the ADM1 is to be included in dynamic simulations of plant-wide or even integrated systems. In this paper, the experiences gained from a Matlab/Simulink implementation of ADM1 into the extended COST/IWA Benchmark Simulation Model (BSM2) are presented. Aspects related to system stiffness, model interfacing with the ASM family, mass balances, acid-base equilibrium and algebraic solvers for pH and other troublesome state variables, numerical solvers and simulation time are discussed. The main conclusion is that if implemented properly, the ADM1 will also produce high-quality results in dynamic plant-wide simulations including noise, discrete sub-systems, etc. without imposing any major restrictions due to extensive computational efforts.

Alcohol ADME in primates studied with positron emission tomography.

PubMed

Li, Zizhong; Xu, Youwen; Warner, Don; Volkow, Nora D

2012-01-01

The sensitivity to the intoxicating effects of alcohol as well as its adverse medical consequences differ markedly among individuals, which reflects in part differences in alcohol's absorption, distribution, metabolism, and elimination (ADME) properties. The ADME of alcohol in the body and its relationship with alcohol's brain bioavailability, however, is not well understood. The ADME of C-11 labeled alcohol, CH(3) (11)CH(2)OH, 1 and C-11 and deuterium dual labeled alcohol, CH(3) (11)CD(2)OH, 2 in baboons was compared based on the principle that C-D bond is stronger than C-H bond, thus the reaction is slower if C-D bond breaking occurs in a rate-determining metabolic step. The following ADME parameters in peripheral organs and brain were derived from time activity curve (TAC) of positron emission tomography (PET) scans: peak uptake (C(max)); peak uptake time (T(max)), half-life of peak uptake (T(1/2)), the area under the curve (AUC(60 min)), and the residue uptake (C(60 min)). For 1 the highest uptake occurred in the kidney whereas for 2 it occurred in the liver. A deuterium isotope effect was observed in the kidneys in both animals studied and in the liver of one animal but not the other. The highest uptake for 1 and 2 in the brain was in striatum and cerebellum but 2 had higher uptake than 1 in all brain regions most evidently in thalamus and cingulate. Alcohol's brain uptake was significantly higher when given intravenously than when given orally and also when the animal was pretreated with a pharmacological dose of alcohol. The study shows that alcohol metabolism in peripheral organs had a large effect on alcohol's brain bioavailability. This study sets the stage for clinical investigation on how genetics, gender and alcohol abuse affect alcohol's ADME and its relationship to intoxication and medical consequences.

Impact of Acellular Dermal Matrix (ADM) Use Under Mastectomy Flap Necrosis on Perioperative Outcomes of Prosthetic Breast Reconstruction.

PubMed

Kim, So Young; Bang, Sa Ik

2017-04-01

There is conflicting data on the potential necrotic complications of acellular dermal matrix (ADM) use in breast reconstruction, and most studies focus on mastectomy flap necrosis as an outcome measure associated with ADM use. The aim of this study was to examine cases with necrotic complications with and without the use of ADM and to investigate whether ADM affected perioperative outcomes in cases with necrotic complications. Patients who experienced mastectomy flap necrosis following mastectomy with tissue expander placement between January 2009 and March 2015 were retrospectively reviewed. The primary outcome was explantation of the expander, and other associated outcomes such as seroma or infection were also recorded. A total of 57 breasts with mastectomy flap necrosis were identified: 32 of which were in the non-ADM group and 25 in the ADM group. The rate of explantation was 28% (7/25) in the ADM group versus 6.3% (2/32) in the non-ADM group, which was significantly different (P = 0.034). The ADM group had a significantly higher rate of "major" infection requiring surgical debridement than the non-ADM group (P = 0.016). Multivariate analysis showed that the use of ADM was trending toward an increasing expander rate with borderline significance (P = 0.05). This study demonstrated that ADM use under mastectomy flap necrosis was a potential risk for explantation of the expander and major infection. Surgeons should be cautious with the use of ADM with devascularized mastectomy skin flaps prone to necrosis. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

The effect of porcine ADM to improve the burn wound healing

PubMed Central

Chen, Xiaodong; Shi, Yan; Shu, Bin; Xie, Xiaoxia; Yang, Ronghua; Zhang, Lijun; Ruan, Shubin; Lin, Yan; Lin, Zepeng; Shen, Rui; Zhang, Fenggang; Feng, Xiangsheng; Xie, Julin

2013-01-01

To study the effect of porcine acellular dermal matrix (ADM) on the burn wound healing. Seventy healthy Wistar rats were inflicted with 2 cm second degree burn and divided into 2 groups; one group was treated with porcine ADM and the other with Povidone Iodine Cream. Biopsies were taken on day 1, 3, 5, 7, 10, 14, 21 for histopathological and biochemical analysis to test PCNA, K19, Integrin-β1, PDGF, EGF and FGF. The results revealed relatively better and faster regeneration after treatment of porcine ADM, along with greatly increased synthesis in collagen in the experimental group. PCNA, K19, Integrin-β1 had an increase and then tapered down, and were stronger in the experimental group than in the contrast group during 21 days after burns. PDGF, EGF and FGF levels increased on day 3, peaked on day 5 and then started to decrease, while significantly enhanced expression of relevant growth factors were observed in the experimental group. Porcine ADM stimulate collagen synthesis, stem cells proliferation and differentiation, and the expression of relevant growth factors and ultimately improve the burn wound healing. PMID:24228089

Implementation of the anaerobic digestion model (ADM1) in the PHREEQC chemistry engine.

PubMed

Huber, Patrick; Neyret, Christophe; Fourest, Eric

2017-09-01

Anaerobic digestion is state-of-the-art technology to treat sludge and effluents from various industries. Modelling and optimisation of digestion operations can be advantageously performed using the anaerobic digestion model (ADM1) from the International Water Association. The ADM1, however, lacks a proper physico-chemical framework, which makes it difficult to consider wastewater of complex ionic composition and supersaturation phenomena. In this work, we present a direct implementation of the ADM1 within the PHREEQC chemistry engine. This makes it possible to handle ionic strength effects and ion-pairing. Thus, multiple mineral precipitation phenomena can be handled while resolving the ADM1. All these features can be accessed with very little programming effort, while retaining the full power and flexibility of PHREEQC. The distributed PHREEQC code can be easily interfaced with process simulation software for future plant-wide simulation of both wastewater and sludge treatment.

Conservative mastectomies and immediate reconstruction with the use of ADMs.

PubMed

Govshievich, Alexander; Somogyi, Ron B; Brown, Mitchell H

2015-12-01

In recent years, a novel approach to immediate breast reconstruction has been introduced with the advent of acellular dermal matrix (ADM). In the setting of conservative mastectomies where the native skin envelope is preserved, placement of ADM at the lower pole in continuity with the pectoralis major muscle (PMM) provides additional support, allowing direct-to-implant breast reconstruction. The following manuscript presents the senior author's experience with ADM-assisted reconstruction and provides a detailed description of surgical technique along with a comprehensive discussion of patient selection and potential complications. A retrospective chart review of patients undergoing direct-to-implant breast reconstruction following skin sparing or nipple sparing mastectomy with the use of ADM (AlloDerm; LifeCell Corp., Branchburg, USA) was conducted at Women's College Hospital in Toronto over a 5-year period [2008-2013]. Demographic data, previous radiation therapy and post-operative complications were recorded. A total of 72 patients representing 119 breasts were identified. Average follow-up was 16 months (range, 3-51 months). Twenty-seven complications were recorded for a complication rate of 22.7% (27/119). Complications included six cases of capsular contracture (Baker III/IV), five cases of red skin syndrome, four cases of rippling, three cases of dehiscence and two cases of seroma. Overall, direct-to-implant reconstruction was successfully completed in 97.5% of breasts (116/119). One case of infection was treated with explantation and conversion to autogenous reconstruction. Two breasts with tissue necrosis or dehiscence had the implants removed and replaced with tissue expanders. Overall reoperation rate was 9.7% (7/72 patients). ADM assisted direct-to-implant breast reconstruction has been shown to be a safe option for women who are candidates for skin sparing or nipple sparing mastectomies. Judicious patient selection, effective collaboration between the

Non-parametric PCM to ADM conversion. [Pulse Code to Adaptive Delta Modulation

NASA Technical Reports Server (NTRS)

Locicero, J. L.; Schilling, D. L.

1977-01-01

An all-digital technique to convert pulse code modulated (PCM) signals into adaptive delta modulation (ADM) format is presented. The converter developed is shown to be independent of the statistical parameters of the encoded signal and can be constructed with only standard digital hardware. The structure of the converter is simple enough to be fabricated on a large scale integrated circuit where the advantages of reliability and cost can be optimized. A concise evaluation of this PCM to ADM translation technique is presented and several converters are simulated on a digital computer. A family of performance curves is given which displays the signal-to-noise ratio for sinusoidal test signals subjected to the conversion process, as a function of input signal power for several ratios of ADM rate to Nyquist rate.

Heterocyclic replacements for benzene: Maximising ADME benefits by considering individual ring isomers.

PubMed

Ritchie, Timothy J; Macdonald, Simon J F

2016-11-29

The impact of replacing a mono-substituted benzene (phenyl) ring with thirty three aromatic and nine aliphatic heterocycles on nine ADME-related screens (solubility, lipophilicity, permeability, protein binding CYP450 inhibition and metabolic clearance) was assessed using matched molecular pair analysis. The results indicate that the influence on the ADME profile can differ significantly depending on the ring identity and importantly on the individual regioisomers that are possible for some rings. This information enables the medicinal chemist to make an informed choice about which rings and regioisomers to employ as mono-substituted benzene replacements, based upon the knowledge of how such replacements are likely to influence ADME-related parameters, for example to target higher solubility whilst avoiding CYP450 liabilities. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Improved ADM1 model for anaerobic digestion process considering physico-chemical reactions.

PubMed

Zhang, Yang; Piccard, Sarah; Zhou, Wen

2015-11-01

The "Anaerobic Digestion Model No. 1" (ADM1) was modified in the study by improving the bio-chemical framework and integrating a more detailed physico-chemical framework. Inorganic carbon and nitrogen balance terms were introduced to resolve the discrepancies in the original bio-chemical framework between the carbon and nitrogen contents in the degraders and substrates. More inorganic components and solids precipitation processes were included in the physico-chemical framework of ADM1. The modified ADM1 was validated with the experimental data and used to investigate the effects of calcium ions, magnesium ions, inorganic phosphorus and inorganic nitrogen on anaerobic digestion in batch reactor. It was found that the entire anaerobic digestion process might exist an optimal initial concentration of inorganic nitrogen for methane gas production in the presence of calcium ions, magnesium ions and inorganic phosphorus. Copyright © 2015 Elsevier Ltd. All rights reserved.

Gaussian processes: a method for automatic QSAR modeling of ADME properties.

PubMed

Obrezanova, Olga; Csanyi, Gabor; Gola, Joelle M R; Segall, Matthew D

2007-01-01

In this article, we discuss the application of the Gaussian Process method for the prediction of absorption, distribution, metabolism, and excretion (ADME) properties. On the basis of a Bayesian probabilistic approach, the method is widely used in the field of machine learning but has rarely been applied in quantitative structure-activity relationship and ADME modeling. The method is suitable for modeling nonlinear relationships, does not require subjective determination of the model parameters, works for a large number of descriptors, and is inherently resistant to overtraining. The performance of Gaussian Processes compares well with and often exceeds that of artificial neural networks. Due to these features, the Gaussian Processes technique is eminently suitable for automatic model generation-one of the demands of modern drug discovery. Here, we describe the basic concept of the method in the context of regression problems and illustrate its application to the modeling of several ADME properties: blood-brain barrier, hERG inhibition, and aqueous solubility at pH 7.4. We also compare Gaussian Processes with other modeling techniques.

Service building. Cross section thru dry dock nos. 4 & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Service building. Cross section thru dry dock nos. 4 & 5 showing service bldg & 20-75-150 ton cranes (dry dock associates, May 23, 1941). In files of Cushman & Wakefield, building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

Service building no. 620. Details of ramps in south end ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Service building no. 620. Details of ramps in south end of service building (Dry Dock Associates, November 7, 1941). In files of Cushman & Wakefiled, building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

Workshop on Aeronautical Decision Making (ADM). Volume 1. Executive Summary

DTIC Science & Technology

1992-08-01

expert and novice pilots when a real decision was required. Aeronautical Decision Making (ADM), Crew Resource Management (CRM), Advanced Qualification Program (AQP), Cognitive Task Analysis (CTA), Expert Decision Making (EDM)

Service building no. 620. Details of of Toilet & Wash ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Service building no. 620. Details of of Toilet & Wash rooms at South end of building (Dry Dock Associates, June 12, 1941). In files of Cushman & Wakefield, building no. 501, Philadephia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

Scientific motivation for ADM/Aeolus mission

NASA Astrophysics Data System (ADS)

Källén, Erland

2018-04-01

The ADM/Aeolus wind lidar mission will provide a global coverage of atmospheric wind profiles. Atmospheric wind observations are required for initiating weather forecast models and for predicting and monitoring long term climate change. Improved knowledge of the global wind field is widely recognised as fundamental to advancing the understanding and prediction of weather and climate. In particular over tropical areas there is a need for better wind data leading to improved medium range (3-10 days) weather forecasts over the whole globe.

Identification of Absorption, Distribution, Metabolism, and Excretion (ADME) Genes Relevant to Steatosis Using a Gene Expression Approach

EPA Science Inventory

Absorption, distribution, metabolism, and excretion (ADME) impact chemical concentration and activation of molecular initiating events of Adverse Outcome Pathways (AOPs) in cellular, tissue, and organ level targets. In order to better describe ADME parameters and how they modulat...

ETRMTR MECHANICAL SERVICES BUILDING, TRA653. CAMERA FACING NORTHWEST AS BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR-MTR MECHANICAL SERVICES BUILDING, TRA-653. CAMERA FACING NORTHWEST AS BUILDING WAS NEARLY COMPLETE. INL NEGATIVE NO. 57-3653. K. Mansfield, Photographer, 7/22/1957 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

A review of ADM1 extensions, applications, and analysis: 2002-2005.

PubMed

Batstone, D J; Keller, J; Steyer, J P

2006-01-01

Since publication of the Scientific and Technical Report (STR) describing the ADM1, the model has been extensively used, and analysed in both academic and practical applications. Adoption of the ADM1 in popular systems analysis tools such as the new wastewater benchmark (BSM2), and its use as a virtual industrial system can stimulate modelling of anaerobic processes by researchers and practitioners outside the core expertise of anaerobic processes. It has been used as a default structural element that allows researchers to concentrate on new extensions such as sulfate reduction, and new applications such as distributed parameter modelling of biofilms. The key limitations for anaerobic modelling originally identified in the STR were: (i) regulation of products from glucose fermentation, (ii) parameter values, and variability, and (iii) specific extensions. Parameter analysis has been widespread, and some detailed extensions have been developed (e.g., sulfate reduction). A verified extension that describes regulation of products from glucose fermentation is still limited, though there are promising fundamental approaches. This is a critical issue, given the current interest in renewable hydrogen production from carbohydrate-type waste. Critical analysis of the model has mainly focused on model structure reduction, hydrogen inhibition functions, and the default parameter set recommended in the STR. This default parameter set has largely been verified as a reasonable compromise, especially for wastewater sludge digestion. One criticism of note is that the ADM1 stoichiometry focuses on catabolism rather than anabolism. This means that inorganic carbon can be used unrealistically as a carbon source during some anabolic reactions. Advances and novel applications have also been made in the present issue, which focuses on the ADM1. These papers also explore a number of novel areas not originally envisaged in this review.

DEVELOPMENT OF ADME DATA IN AGRICULTURAL CHEMICAL SAFETY ASSESSMENTS

EPA Science Inventory

DEVELOPMENT OF ADME DATA IN AGRICULTURAL CHEMICAL SAFETY ASSESSMENTS
Pastoor, Timothy1, Barton, Hugh2
1 Syngenta Crop Protection, Greensboro, NC, USA.
2 EPA, Office of Research and Development-NHEERL, RTP, NC, USA.

A multi-stakeholder series of discussions d...

Modified ADM1 for modeling free ammonia inhibition in anaerobic acidogenic fermentation with high-solid sludge.

PubMed

Bai, Jie; Liu, He; Yin, Bo; Ma, Huijun; Chen, Xinchun

2017-02-01

Anaerobic acidogenic fermentation with high-solid sludge is a promising method for volatile fatty acid (VFA) production to realize resource recovery. In this study, to model inhibition by free ammonia in high-solid sludge fermentation, the anaerobic digestion model No. 1 (ADM1) was modified to simulate the VFA generation in batch, semi-continuous and full scale sludge. The ADM1 was operated on the platform AQUASIM 2.0. Three kinds of inhibition forms, e.g., simple inhibition, Monod and non-inhibition forms, were integrated into the ADM1 and tested with the real experimental data for batch and semi-continuous fermentation, respectively. The improved particle swarm optimization technique was used for kinetic parameter estimation using the software MATLAB 7.0. In the modified ADM1, the K s of acetate is 0.025, the k m,ac is 12.51, and the K I_NH3 is 0.02, respectively. The results showed that the simple inhibition model could simulate the VFA generation accurately while the Monod model was the better inhibition kinetics form in semi-continuous fermentation at pH10.0. Finally, the modified ADM1 could successfully describe the VFA generation and ammonia accumulation in a 30m 3 full-scale sludge fermentation reactor, indicating that the developed model can be applicable in high-solid sludge anaerobic fermentation. Copyright © 2016. Published by Elsevier B.V.

25 CFR 39.204 - How does OIEP calculate ADM?

Code of Federal Regulations, 2010 CFR

2010-04-01

... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Administrative Procedures, Student Counts, and Verifications § 39.204 How does OIEP calculate ADM... each Bureau-funded school; and (b) Dividing the total enrollment for each school by the number of days...

Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP)

PubMed Central

Wilkinson, Ian B; McEniery, Carmel M; Bongaerts, Katherine H; MacCallum, Helen; Webb, David J; Cockcroft, John R

2001-01-01

Aims To compare the haemodynamic responses of proadrenomedullin N-terminal 20 peptide (PAMP) and adrenomedullin (ADM) in the forearm vascular bed of healthy male volunteers, and to investigate the role of neutral endopeptidase (NEP) in the metabolism of ADM. Methods On two separate occasions, ADM (1–30 pmol min−1) and PAMP (100–3000 pmol min−1) were infused into the brachial artery of eight male subjects, and forearm blood flow (FBF) assessed using venous occlusion plethysmography. In a second study, eight male subjects received the same doses of ADM, co-infused with either the NEP inhibitor thiorphan (30 nmol min−1) or the control vasoconstrictor noradrenaline (120 pmol min−1), on separate occasions. Both studies were conducted in a double-blind, randomized manner. Results ADM and PAMP produced a dose-dependent increase in FBF (P ≤ 0.002). Based on the dose producing a 50% increase in FBF, ADM was ∼60 times more potent than PAMP. Thiorphan and noradrenaline produced similar reductions in FBF of 14 ± 4% (mean ± s.e. mean) and 22 ± 6%, respectively (P = 0.4). However, the area under the dose–response curve was significantly greater during co-infusion of ADM with thiorphan than with noradrenaline (P = 0.028), as was the maximum increase in FBF ratio (2.1 ± 1.0 vs 1.2 ± 0.2; P = 0.030). Conclusions ADM and PAMP both produce a local dose-related vasodilatation in the human forearm, but PAMP is ∼60 times less potent than ADM. In addition, NEP inhibition potentiates the haemodynamic effects of ADM. These findings suggest that PAMP may not play a role in the physiological regulation of blood flow. However, in pathophysiological conditions such as hypertension and heart failure, NEP inhibition may exert a beneficial effect by increasing the biological activity of ADM. PMID:11488772

Identification of Absorption, Distribution, Metabolism, and Excretion (ADME) Genes Relevant to Steatosis Using a Differential Gene Expression Approach

EPA Science Inventory

Absorption, distribution, metabolism, and excretion (ADME) parameters represent important connections between exposure to chemicals and the activation of molecular initiating events of Adverse Outcome Pathways (AOPs) in cellular, tissue, and organ level targets. ADME parameters u...

Principles and techniques in the design of ADMS+. [advanced data-base management system

NASA Technical Reports Server (NTRS)

Roussopoulos, Nick; Kang, Hyunchul

1986-01-01

'ADMS+/-' is an advanced data base management system whose architecture integrates the ADSM+ mainframe data base system with a large number of work station data base systems, designated ADMS-; no communications exist between these work stations. The use of this system radically decreases the response time of locally processed queries, since the work station runs in a single-user mode, and no dynamic security checking is required for the downloaded portion of the data base. The deferred update strategy used reduces overhead due to update synchronization in message traffic.

Service building no. 620. Elevations (dry dock associates, June 12, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Service building no. 620. Elevations (dry dock associates, June 12, 1941). In files of Cushman & Wakefield, building 501, Philadephia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

Recent developments in software tools for high-throughput in vitro ADME support with high-resolution MS.

PubMed

Paiva, Anthony; Shou, Wilson Z

2016-08-01

The last several years have seen the rapid adoption of the high-resolution MS (HRMS) for bioanalytical support of high throughput in vitro ADME profiling. Many capable software tools have been developed and refined to process quantitative HRMS bioanalysis data for ADME samples with excellent performance. Additionally, new software applications specifically designed for quan/qual soft spot identification workflows using HRMS have greatly enhanced the quality and efficiency of the structure elucidation process for high throughput metabolite ID in early in vitro ADME profiling. Finally, novel approaches in data acquisition and compression, as well as tools for transferring, archiving and retrieving HRMS data, are being continuously refined to tackle the issue of large data file size typical for HRMS analyses.

Service building no. 620. Typical wall sections (Dry Dock Associates, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Service building no. 620. Typical wall sections (Dry Dock Associates, November 7, 1941). In files of Cushman & Wakefield Building (no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

48 CFR 552.232-72 - Final Payment Under Building Services Contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Building Services Contracts. 552.232-72 Section 552.232-72 Federal Acquisition Regulations System GENERAL... and Clauses 552.232-72 Final Payment Under Building Services Contracts. As prescribed in 532.904(c), insert the following clause: Final Payment Under Building Services Contracts (NOV 2009) Before final...

An ASM/ADM model interface for dynamic plant-wide simulation.

PubMed

Nopens, Ingmar; Batstone, Damien J; Copp, John B; Jeppsson, Ulf; Volcke, Eveline; Alex, Jens; Vanrolleghem, Peter A

2009-04-01

Mathematical modelling has proven to be very useful in process design, operation and optimisation. A recent trend in WWTP modelling is to include the different subunits in so-called plant-wide models rather than focusing on parts of the entire process. One example of a typical plant-wide model is the coupling of an upstream activated sludge plant (including primary settler, and secondary clarifier) to an anaerobic digester for sludge digestion. One of the key challenges when coupling these processes has been the definition of an interface between the well accepted activated sludge model (ASM1) and anaerobic digestion model (ADM1). Current characterisation and interface models have key limitations, the most critical of which is the over-use of X(c) (or lumped complex) variable as a main input to the ADM1. Over-use of X(c) does not allow for variation of degradability, carbon oxidation state or nitrogen content. In addition, achieving a target influent pH through the proper definition of the ionic system can be difficult. In this paper, we define an interface and characterisation model that maps degradable components directly to carbohydrates, proteins and lipids (and their soluble analogues), as well as organic acids, rather than using X(c). While this interface has been designed for use with the Benchmark Simulation Model No. 2 (BSM2), it is widely applicable to ADM1 input characterisation in general. We have demonstrated the model both hypothetically (BSM2), and practically on a full-scale anaerobic digester treating sewage sludge.

48 CFR 652.236-71 - Foreign Service Buildings Act, as Amended.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Foreign Service Buildings....236-71 Foreign Service Buildings Act, as Amended. As prescribed in 636.570(a), insert the following provision: Foreign Service Buildings Act, as Amended (APR 2004) (a) This solicitation is subject to Section...

LOFT. Containment building (TAN650) detail. Camera facing east. Service building ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment building (TAN-650) detail. Camera facing east. Service building corner is at left of view above personnel access. Round feature at left of dome is tank that will contain borated water. Metal stack at right of view. Date: 1973. INEEL negative no. 73-1085 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Development of an Excel-based laboratory information management system for improving workflow efficiencies in early ADME screening.

PubMed

Lu, Xinyan

2016-01-01

There is a clear requirement for enhancing laboratory information management during early absorption, distribution, metabolism and excretion (ADME) screening. The application of a commercial laboratory information management system (LIMS) is limited by complexity, insufficient flexibility, high costs and extended timelines. An improved custom in-house LIMS for ADME screening was developed using Excel. All Excel templates were generated through macros and formulae, and information flow was streamlined as much as possible. This system has been successfully applied in task generation, process control and data management, with a reduction in both labor time and human error rates. An Excel-based LIMS can provide a simple, flexible and cost/time-saving solution for improving workflow efficiencies in early ADME screening.

Dry dock no. 4. Service Building between dry docks 4 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Dry dock no. 4. Service Building between dry docks 4 and 5. Floor plans (Navy Yard Public Works Office 1941). In files of Cushman & Wakefield, building 501. Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process.

PubMed

An, Fan; Qu, Yueyang; Luo, Yong; Fang, Ning; Liu, Yang; Gao, Zhigang; Zhao, Weijie; Lin, Bingcheng

2016-04-28

New techniques are urgently needed to replace conventional long and costly pre-clinical testing in the new drug administration process. In this study, a laminated microfluidic device was fabricated to mimic the drug ADME response test in vivo. This proposed device was loaded and cultured with functional cells for drug response investigation and organ tissues that are involved in ADME testing. The drug was introduced from the top of the device and first absorbed by the Caco-2 cell layer, and then metabolized by the primary hepatocyte layer. It subsequently interacted with the MCF-7 cell layer, distributed in the lung, heart and fat tissues, and was finally eliminated through the dialysis membrane. Throughout this on-chip ADME process, the proposed device can be used as a reliable tool to simultaneously evaluate the drug anti-tumor activity, hepatotoxicity and pharmacokinetics. Furthermore, this device was proven to be able to reflect the hepatic metabolism of a drug, drug distribution in the target tissues, and the administration method of a drug. Furthermore, this microdevice is expected to reduce the number of drug candidates and accelerate the pre-clinical testing process subject to animal testing upon adaptation in new drug discovery.

Application of ADM1 for modeling of biogas production from anaerobic digestion of Hydrilla verticillata.

PubMed

Chen, Xiaojuan; Chen, Zhihua; Wang, Xun; Huo, Chan; Hu, Zhiquan; Xiao, Bo; Hu, Mian

2016-07-01

The present study focused on the application of anaerobic digestion model no. 1 (ADM1) to simulate biogas production from Hydrilla verticillata. Model simulation was carried out by implementing ADM1 in AQUASIM 2.0 software. Sensitivity analysis was used to select the most sensitive parameters for estimation using the absolute-relative sensitivity function. Among all the kinetic parameters, disintegration constant (kdis), hydrolysis constant of protein (khyd_pr), Monod maximum specific substrate uptake rate (km_aa, km_ac, km_h2) and half-saturation constants (Ks_aa, Ks_ac) affect biogas production significantly, which were optimized by fitting of the model equations to the data obtained from batch experiments. The ADM1 model after parameter estimation was able to well predict the experimental results of daily biogas production and biogas composition. The simulation results of evolution of organic acids, bacteria concentrations and inhibition effects also helped to get insight into the reaction mechanisms. Copyright © 2016. Published by Elsevier Ltd.

Modeling microbial diversity in anaerobic digestion through an extended ADM1 model.

PubMed

Ramirez, Ivan; Volcke, Eveline I P; Rajinikanth, Rajagopal; Steyer, Jean-Philippe

2009-06-01

The anaerobic digestion process comprises a whole network of sequential and parallel reactions, of both biochemical and physicochemical nature. Mathematical models, aiming at understanding and optimization of the anaerobic digestion process, describe these reactions in a structured way, the IWA Anaerobic Digestion Model No. 1 (ADM1) being the most well established example. While these models distinguish between different microorganisms involved in different reactions, to our knowledge they all neglect species diversity between organisms with the same function, i.e. performing the same reaction. Nevertheless, available experimental evidence suggests that the structure and properties of a microbial community may be influenced by process operation and on their turn also determine the reactor functioning. In order to adequately describe these phenomena, mathematical models need to consider the underlying microbial diversity. This is demonstrated in this contribution by extending the ADM1 to describe microbial diversity between organisms of the same functional group. The resulting model has been compared with the traditional ADM1 in describing experimental data of a pilot-scale hybrid Upflow Anaerobic Sludge Filter Bed (UASFB) reactor, as well as in a more detailed simulation study. The presented model is further shown useful in assessing the relationship between reactor performance and microbial community structure in mesophilic CSTRs seeded with slaughterhouse wastewater when facing increasing levels of ammonia.

Marine Science Building Dedicated

NASA Image and Video Library

2003-10-17

Officials cut the ribbon during dedication ceremonies of the George A. Knauer Marine Science Building on Oct. 17 at NASA Stennis Space Center (SSC). The $2.75 million facility, the first building at the test site funded by the state of Mississippi, houses six science labs, classrooms and office space for 40 faculty and staff. Pictured are, from left, Rear Adm. Thomas Donaldson, commander of the Naval Meteorology and Oceanography Command; SSC Assistant Director David Throckmorton; Dr. George A. Knauer, founder of the Center of Marine Science at the University of Southern Mississippi (USM); Lt. Gov. Amy Tuck; and USM President Dr. Shelby Thames.

Marine Science Building Dedicated

NASA Technical Reports Server (NTRS)

2003-01-01

Officials cut the ribbon during dedication ceremonies of the George A. Knauer Marine Science Building on Oct. 17 at NASA Stennis Space Center (SSC). The $2.75 million facility, the first building at the test site funded by the state of Mississippi, houses six science labs, classrooms and office space for 40 faculty and staff. Pictured are, from left, Rear Adm. Thomas Donaldson, commander of the Naval Meteorology and Oceanography Command; SSC Assistant Director David Throckmorton; Dr. George A. Knauer, founder of the Center of Marine Science at the University of Southern Mississippi (USM); Lt. Gov. Amy Tuck; and USM President Dr. Shelby Thames.

Service Building No. 620. Detail of north elevation and entrance ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Service Building No. 620. Detail of north elevation and entrance to substation & windowns in top of elevator shafts no. 2 & stair no. 1 & section thru substation (dry dock associates, June 12, 1941). In files of Cushman & Wakefield, building 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

Promoting personal safety of building service workers: issues and challenges.

PubMed

Chen, Shelley I; Skillen, D Lynn

2006-06-01

This exploratory, descriptive study conducted at a large western Canadian university solicited perceptions of personal safety among building service workers who perform night shift work alone. Ten semi-structured interviews were conducted at approximately 10:00 p.m. or 7:00 a.m with a convenience sample of night building service workers in private or semi-private locations on the university campus. Transcribed interview data were subjected to inductive content analysis using descriptive, interpretive, and pattern coding (Miles & Huberman, 1994). Results suggest that building service night shift workers are exposed to personal safety hazards in their physical and psychosocial work environments. In addition, culturally and linguistically appropriate delivery of safety training and education about policies and procedures is required for culturally diverse building service workers. Promotion of personal safety in this heterogeneous worker population requires due diligence, assessment, and advocacy.

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway

PubMed Central

Gao, Ai-Mei; Zhang, Xiao-Yu; Ke, Zun-Ping

2017-01-01

Chemo-resistance is one of the main obstacle in hepatocellular carcinoma therapy. Apigenin as a natural bioflavonoid has been exhibited anti-cancer properties in various malignant cancers. The aim of this study is to evaluate the potential chemo-sensitization effect of apigenin in doxorubicin-resistant hepatocellular carcinoma cell line BEL-7402/ADM and to investigate its possible mechanism. We found that apigenin significantly reversed doxorubicin sensitivity and induced caspase-dependent apoptosis in BEL-7402/ADM cells. Furthermore, apigenin induced miR-101 expression, and overexpression of miR-101 mimicked the doxorubicin-sensitizing effect of apigenin. Importantly, we showed that miR-101 was able to target the 3′-UTR of Nrf2. The results suggested that apigenin sensitizes BEL-7402/ADM cells to doxorubicin through miR-101/Nrf2 pathway, which furtherly supports apigenin as a potential chemo-sensitizer for hepatocellular carcinoma. PMID:29137246

A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process

PubMed Central

An, Fan; Qu, Yueyang; Luo, Yong; Fang, Ning; Liu, Yang; Gao, Zhigang; Zhao, Weijie; Lin, Bingcheng

2016-01-01

New techniques are urgently needed to replace conventional long and costly pre-clinical testing in the new drug administration process. In this study, a laminated microfluidic device was fabricated to mimic the drug ADME response test in vivo. This proposed device was loaded and cultured with functional cells for drug response investigation and organ tissues that are involved in ADME testing. The drug was introduced from the top of the device and first absorbed by the Caco-2 cell layer, and then metabolized by the primary hepatocyte layer. It subsequently interacted with the MCF-7 cell layer, distributed in the lung, heart and fat tissues, and was finally eliminated through the dialysis membrane. Throughout this on-chip ADME process, the proposed device can be used as a reliable tool to simultaneously evaluate the drug anti-tumor activity, hepatotoxicity and pharmacokinetics. Furthermore, this device was proven to be able to reflect the hepatic metabolism of a drug, drug distribution in the target tissues, and the administration method of a drug. Furthermore, this microdevice is expected to reduce the number of drug candidates and accelerate the pre-clinical testing process subject to animal testing upon adaptation in new drug discovery. PMID:27122192

ADM. Tanks: from left to right: fuel oil tank, fuel ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Tanks: from left to right: fuel oil tank, fuel pump house (TAN-611), engine fuel tank, water pump house, water storage tank. Camera facing northwest. Not edge of shielding berm at left of view. Date: November 25, 1953. INEEL negative no. 9217 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Pharmacokinetic properties and in silico ADME modeling in drug discovery.

PubMed

Honório, Kathia M; Moda, Tiago L; Andricopulo, Adriano D

2013-03-01

The discovery and development of a new drug are time-consuming, difficult and expensive. This complex process has evolved from classical methods into an integration of modern technologies and innovative strategies addressed to the design of new chemical entities to treat a variety of diseases. The development of new drug candidates is often limited by initial compounds lacking reasonable chemical and biological properties for further lead optimization. Huge libraries of compounds are frequently selected for biological screening using a variety of techniques and standard models to assess potency, affinity and selectivity. In this context, it is very important to study the pharmacokinetic profile of the compounds under investigation. Recent advances have been made in the collection of data and the development of models to assess and predict pharmacokinetic properties (ADME--absorption, distribution, metabolism and excretion) of bioactive compounds in the early stages of drug discovery projects. This paper provides a brief perspective on the evolution of in silico ADME tools, addressing challenges, limitations, and opportunities in medicinal chemistry.

Building and Home Maintenance Services.

ERIC Educational Resources Information Center

Michigan State Univ., East Lansing. Coll. of Agriculture and Natural Resources Education Inst.

This task-based curriculum guide for building and home maintenance services is intended to help the teacher develop a classroom management system where students learn by doing. Introductory materials include a Dictionary of Occupational Titles job code and title sheet, a career ladder, a matrix relating duty/task numbers to job titles, and a task…

Biosynthesis of the acetyl‐CoA carboxylase‐inhibiting antibiotic, andrimid in Serratia is regulated by Hfq and the LysR‐type transcriptional regulator, AdmX

PubMed Central

Nogellova, Veronika; Morel, Bertrand; Krell, Tino

2016-01-01

Summary Infections due to multidrug‐resistant bacteria represent a major global health challenge. To combat this problem, new antibiotics are urgently needed and some plant‐associated bacteria are a promising source. The rhizobacterium Serratia plymuthica A153 produces several bioactive secondary metabolites, including the anti‐oomycete and antifungal haterumalide, oocydin A and the broad spectrum polyamine antibiotic, zeamine. In this study, we show that A153 produces a second broad spectrum antibiotic, andrimid. Using genome sequencing, comparative genomics and mutagenesis, we defined new genes involved in andrimid (adm) biosynthesis. Both the expression of the adm gene cluster and regulation of andrimid synthesis were investigated. The biosynthetic cluster is operonic and its expression is modulated by various environmental cues, including temperature and carbon source. Analysis of the genome context of the adm operon revealed a gene encoding a predicted LysR‐type regulator, AdmX, apparently unique to Serratia strains. Mutagenesis and gene expression assays demonstrated that AdmX is a transcriptional activator of the adm gene cluster. At the post‐transcriptional level, the expression of the adm cluster is positively regulated by the RNA chaperone, Hfq, in an RpoS‐independent manner. Our results highlight the complexity of andrimid biosynthesis – an antibiotic with potential clinical and agricultural utility. PMID:26914969

ADM-CLE Approach for Detecting Slow Variables in Continuous Time Markov Chains and Dynamic Data

DTIC Science & Technology

2015-04-01

Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, United Kingdom. E -mail: erban@maths.ox.ac.uk; Radek Erban would like to thank the Royal Society...more e cient than the ADM method for a large class of chemical reaction systems, because it replaces the computationally most expensive step of ADM...i.e., m = 4), given by ∅ k1 −→ X1 k2−→←− k3 X2 k4−→ ∅. (2.2) Throughout the rest of this paper, we shall refer to the chemical system (2.2) as CS-I (i.e

Reference intervals and longitudinal changes in copeptin and MR-proADM concentrations during pregnancy.

PubMed

Joosen, Annemiek M C P; van der Linden, Ivon J M; Schrauwen, Lianne; Theeuwes, Alisia; de Groot, Monique J M; Ermens, Antonius A M

2017-11-27

Vasopressin and adrenomedullin and their stable by-products copeptin and midregional part of proadrenomedullin (MR-proADM) are promising biomarkers for the development of preeclampsia. However, clinical use is hampered by the lack of trimester-specific reference intervals. We therefore estimated reference intervals for copeptin and MR-proADM in disease-free Dutch women throughout pregnancy. Apparently healthy low risk pregnant women were recruited. Exclusion criteria included current or past history of endocrine disease, multiple pregnancy, use of medication known to influence thyroid function and current pregnancy as a result of hormonal stimulation. Women who miscarried, developed hyperemesis gravidarum, hypertension, pre-eclampsia, hemolysis elevated liver enzymes and low platelets, diabetes or other disease, delivered prematurely or had a small for gestational age neonate were excluded from analyses. Blood samples were collected at 9-13 weeks (n=98), 27-29 weeks (n=94) and 36-39 weeks (n=91) of gestation and at 4-13 weeks post-partum (PP) (n=89). Sixty-two women had complete data during pregnancy and PP. All analyses were performed on a Kryptor compact plus. Copeptin increases during pregnancy, but 97.5th percentiles remain below the non-pregnant upper reference limit (URL) provided by the manufacturer. MR-proADM concentrations increase as well during pregnancy. In trimesters 2 and 3 the 97.5th percentiles are over three times the non-pregnant URL provided by the manufacturer. Trimester- and assay-specific reference intervals for copeptin and MR-proADM should be used. In addition, consecutive measurements and the time frame between measurements should be considered as the differences seen with or in advance of preeclampsia can be expected to be relatively small compared to the reference intervals.

ADM. Change House (TAN606). Elevations and floor plan. Room Names. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Change House (TAN-606). Elevations and floor plan. Room Names. Ralph M. Parsons 902-2-ANP-606-A 65. Date: December 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0606-00-693-106733 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

ADM. Warehouse (TAN604) Floor plan. General warehouse and chemical storage. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Warehouse (TAN-604) Floor plan. General warehouse and chemical storage. Ralph M. Parsons 902-2-ANP-604-A 55. Date: December 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0604-00-693-106727 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

ADM. Water System Pump House (TAN610). Elevations, plan, and sections. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Water System Pump House (TAN-610). Elevations, plan, and sections. Ralph M. Parsons 902-2-ANP-610-A 74. Date: February 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0610-00-693-106739 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Building evaluative culture in community services: Caring for evidence.

PubMed

Mayne, John

2017-05-25

An organization with a strong evaluative culture engages in self-reflection, evidence-based learning and experimentation. It sees evidence as essential for managing well, but building such a culture is challenging. Community service organizations seek to provide effective services for their clients. To build an evaluative culture, they need to acquire basic monitoring and evaluation capabilities, be provided with opportunities for using these capabilities and be adequately motivated to care about evidence as a means to improve services to their clients. Leadership along with a phased in approach are key in bringing about these behaviour changes. Copyright © 2017. Published by Elsevier Ltd.

Modified version of ADM1 model for agro-waste application.

PubMed

Galí, A; Benabdallah, T; Astals, S; Mata-Alvarez, J

2009-06-01

Agro-residues account for a large proportion of the wastes generated around the world. There is thus a need for a model to simulate the anaerobic digestion processes used in their treatment. We have developed model based on ADM1, to be applied to agro-wastes. We examined and tested the biodegradability of apple, pear, orange, rape, sunflower, pig manure and glycerol wastes to be used as the basis for feeding the model. Moreover, the fractions of particulate COD (X(c)) were calculated, and the disintegration constant was obtained from biodegradability profiles, considering disintegration to be the limiting process. The other kinetic and stoichiometric parameters were taken from the ADM1 model. The model operating under mono-substrate and co-substrate conditions was then validated with batch tests. At the same time the model was validated on a continuous anaerobic reactor operating with pig manure at lab scale. In both cases the correlation between the model and the experimental results was satisfactory. We conclude that the anaerobic digestion model is a reliable tool for the design and operation of plants in which agro-wastes are treated.

Identifiability of large-scale non-linear dynamic network models applied to the ADM1-case study.

PubMed

Nimmegeers, Philippe; Lauwers, Joost; Telen, Dries; Logist, Filip; Impe, Jan Van

2017-06-01

In this work, both the structural and practical identifiability of the Anaerobic Digestion Model no. 1 (ADM1) is investigated, which serves as a relevant case study of large non-linear dynamic network models. The structural identifiability is investigated using the probabilistic algorithm, adapted to deal with the specifics of the case study (i.e., a large-scale non-linear dynamic system of differential and algebraic equations). The practical identifiability is analyzed using a Monte Carlo parameter estimation procedure for a 'non-informative' and 'informative' experiment, which are heuristically designed. The model structure of ADM1 has been modified by replacing parameters by parameter combinations, to provide a generally locally structurally identifiable version of ADM1. This means that in an idealized theoretical situation, the parameters can be estimated accurately. Furthermore, the generally positive structural identifiability results can be explained from the large number of interconnections between the states in the network structure. This interconnectivity, however, is also observed in the parameter estimates, making uncorrelated parameter estimations in practice difficult. Copyright © 2017. Published by Elsevier Inc.

ADM Analysis of gravity models within the framework of bimetric variational formalism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Golovnev, Alexey; Karčiauskas, Mindaugas; Nyrhinen, Hannu J., E-mail: agolovnev@yandex.ru, E-mail: mindaugas.karciauskas@helsinki.fi, E-mail: hannu.nyrhinen@helsinki.fi

2015-05-01

Bimetric variational formalism was recently employed to construct novel bimetric gravity models. In these models an affine connection is generated by an additional tensor field which is independent of the physical metric. In this work we demonstrate how the ADM decomposition can be applied to study such models and provide some technical intermediate details. Using ADM decomposition we are able to prove that a linear model is unstable as has previously been indicated by perturbative analysis. Moreover, we show that it is also very difficult if not impossible to construct a non-linear model which is ghost-free within the framework ofmore » bimetric variational formalism. However, we demonstrate that viable models are possible along similar lines of thought. To this end, we consider a set up in which the affine connection is a variation of the Levi-Civita one. As a proof of principle we construct a gravity model with a massless scalar field obtained this way.« less

Modeling work of the dispatching service of high-rise building as queuing system

NASA Astrophysics Data System (ADS)

Dement'eva, Marina; Dement'eva, Anastasiya

2018-03-01

The article presents the results of calculating the performance indicators of the dispatcher service of a high-rise building as a queuing system with an unlimited queue. The calculation was carried out for three models: with a single control room and brigade of service, with a single control room and a specialized service, with several dispatch centers and specialized services. The aim of the work was to investigate the influence of the structural scheme of the organization of the dispatcher service of a high-rise building on the amount of operating costs and the time of processing and fulfilling applications. The problems of high-rise construction and their impact on the complication of exploitation are analyzed. The composition of exploitation activities of high-rise buildings is analyzed. The relevance of the study is justified by the need to review the role of dispatch services in the structure of management of the quality of buildings. Dispatching service from the lower level of management of individual engineering systems becomes the main link in the centralized automated management of the exploitation of high-rise buildings. With the transition to market relations, the criterion of profitability at the organization of the dispatching service becomes one of the main parameters of the effectiveness of its work. A mathematical model for assessing the efficiency of the dispatching service on a set of quality of service indicators is proposed. The structure of operating costs is presented. The algorithm of decision-making is given when choosing the optimal structural scheme of the dispatching service of a high-rise building.

Essential Set of Molecular Descriptors for ADME Prediction in Drug and Environmental Chemical Space

EPA Science Inventory

Historically, the disciplines of pharmacology and toxicology have embraced quantitative structure-activity relationships (QSAR) and quantitative structure-property relationships (QSPR) to predict ADME properties or biological activities of untested chemicals. The question arises ...

ADM. Fuel Pump House (TAN611). Elevations, floor plan. Drawing includes ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Fuel Pump House (TAN-611). Elevations, floor plan. Drawing includes elevation and plans for "H.M." structures (Hose Storage?). Ralph M. Parsons 902-2-ANP-611-A 78 Date: December 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0611-00-693-106741 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

LOFT. Containment and service building (TAN650) basement floor plan. Basement ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650) basement floor plan. Basement airlock, shielded roadway, service areas, connection to control building. Kaiser engineers 6413-11-STEP/LOFT-650-A-1. Date: October 1964. INEEL index code no. 036-650-00-416-122213 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with community-acquired pneumonia: a systematic review and meta-analysis.

PubMed

Liu, Dan; Xie, Lixin; Zhao, Haiyan; Liu, Xueyao; Cao, Jie

2016-05-26

The early identification of patients at risk of dying from community-acquired pneumonia (CAP) is critical for their treatment and for defining hospital resource consumption. Mid-regional pro-adrenomedullin (MR-proADM) has been extensively investigated for its prognostic value in CAP. However, the results are conflicting. The purpose of the present meta-analysis was to explore the diagnostic accuracy of MR-proADM for predicting mortality in patients suffering from CAP, particularly emergency department (ED) patients. We systematically searched the PubMed, Embase, Web of Knowledge and Cochrane databases. Studies were included if a 2 × 2 contingency table could be constructed based on both the MR-proADM level and the complications or mortality of patients diagnosed with CAP. The prognostic accuracy of MR-proADM in CAP was assessed using the bivariate meta-analysis model. We used the Q-test and I (2) index to evaluate heterogeneity. MR-proADM displayed moderate diagnostic accuracy for predicting complications in CAP, with an overall area under the SROC curve (AUC) of 0.74 (95 % CI: 0.70-0.78). Eight studies with a total of 4119 patients in the emergency department (ED) were included. An elevated MR-proADM level was associated with increased risk of death from CAP (RR 6.16, 95 % CI 4.71-8.06); the I (2) value was 0.0 %, and a fixed-effects model was used to pool RR. The pooled sensitivity and specificity were 0.74 (95 % CI: 0.67-0.79) and 0.73 (95 % CI: 0.70-0.77), respectively. The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 2.8 (95 % CI, 2.3-3.3) and 0.36 (95 % CI, 0.29-0.45), respectively. In addition, the diagnostic odds ratio (DOR) was 8 (95 % CI, 5-11), and the overall area under the SROC curve was 0.76 (95 % CI, 0.72-0.80). Our study has demonstrated that MR-proADM is predictive of increased complications and higher mortality rates in patients suffering from CAP. Future studies are warranted to determine the prognostic

Modelling mono-digestion of grass silage in a 2-stage CSTR anaerobic digester using ADM1.

PubMed

Thamsiriroj, T; Murphy, J D

2011-01-01

This paper examines 174 days of experimental data and modelling of mono-digestion of grass silage in a two stage wet process with recirculation of liquor; the two vessels have an effective volume of 312 L each. The organic loading rate is initiated at 0.5 kg VS m(-3) d(-1) (first 74 days) and subsequently increased to 1 kg VS m(-3) d(-1). The experimental data was used to generate a mathematical model (ADM1) which was calibrated over the first 74 days of operation. Good accuracy with experimental data was found for the subsequent 100 days. Results of the model would suggest starting the process without recirculation and thus building up the solids content of the liquor. As the level of VFA increases, recirculation should be employed to control VFA. Recirculation also controls solids content and pH. Methane production was estimated at 88% of maximum theoretical production. Copyright © 2010 Elsevier Ltd. All rights reserved.

48 CFR 532.905-70 - Final payment-construction and building service contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply to construction and building service contracts: (a) The Government shall pay the final amount due the Contractor...

48 CFR 532.905-70 - Final payment-construction and building service contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply to construction and building service contracts: (a) The Government shall pay the final amount due the Contractor...

48 CFR 532.905-70 - Final payment-construction and building service contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Final payment-construction...-70 Final payment—construction and building service contracts. The following procedures apply to construction and building service contracts: (a) The Government shall pay the final amount due the Contractor...

ADM. Water well pump houses (TAN612 and TAN613). Plans, elevations, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Water well pump houses (TAN-612 and TAN-613). Plans, elevations, floor and other details. Ralph M. Parsons 902-2-ANP-612-613-A S & P 82. Date: December 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0612-00-693-106743 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

SSMNG Software Service Manager: A Scalable Building Blocks Architecture for PUS Services & FDIR Management

NASA Astrophysics Data System (ADS)

Lisio, Giovanni; Candia, Sante; Campolo, Giovanni; Pascucci, Dario

2011-08-01

Thales Alenia Space Italy has carried out the definition of a configurable (on mission basis) PUS ECSS-E_70- 41A see [3] Centralised Services Layer, characterised by:- a mission-independent set of 'classes' implementing the services logic.- a mission-dependent set of configuration data and selection flags.The software components belonging to this layer implement the PUS standard services ECSS-E_70-41A and a set of mission-specific services. The design of this layer has been performed by separating the services mechanisms (mission-independent execution logic) from the services configuration information (mission-dependent data). Once instantiated for a specific mission, the PUS Centralised Services Layer offers a large set of capabilities available to the CSCI's Applications Layer. This paper describes the building blocks PUS architectural solution developed by Thales Alenia Space Italy, emphasizing the mechanisms which allow easy configuration of the Scalable PUS library to fulfill the requirements of different missions. This paper also focus the Thales Alenia Space solution to automatically generate the mission-specific "PUS Services" flight software based on mission specific requirements. Building the PUS services mechanisms, which are configurable on mission basis is part of the PRIMA (Multipurpose Spacecraft Bus ) 'missionisation' process improvement. PRIMA Platform Avionics Software (ASW) is continuously evolving to improve modularity and standardization of interfaces and of SW components (see references in [1]).

REACTOR SERVICE BUILDING, TRA635, CONTEXTUAL VIEW DURING CONSTRUCTION. CAMERA IS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

REACTOR SERVICE BUILDING, TRA-635, CONTEXTUAL VIEW DURING CONSTRUCTION. CAMERA IS ATOP MTR BUILDING AND LOOKING SOUTHERLY. FOUNDATION AND DRAINS ARE UNDER CONSTRUCTION. THE BUILDING WILL BUTT AGAINST CHARGING FACE OF PLUG STORAGE BUILDING. HOT CELL BUILDING, TRA-632, IS UNDER CONSTRUCTION AT TOP CENTER OF VIEW. INL NEGATIVE NO. 8518. Unknown Photographer, 8/25/1953 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

CCC CAMP WICKIUP – OFFICE BUILDING, CENTER; TECHNICAL SERVICE QUARTERS, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

CCC CAMP WICKIUP – OFFICE BUILDING, CENTER; TECHNICAL SERVICE QUARTERS, RIGHT; EDUCATIONAL BUILDING, LEFT. Photocopy of historic photographs (original photograph on file at National Archives, Rocky Mountain Region, Denver, CO). Unknown USBR Photographer, December 9, 1938 - Wickiup Dam, Deschutes River, La Pine, Deschutes County, OR

Induction of apoptosis and reversal of permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM by ginsenoside Rh2.

PubMed

Zhang, Hui; Gong, Jian; Zhang, Huilai; Kong, Di

2015-01-01

Multidrug resistance is a phenomenon that cancer cells develop a cross-resistant phenotype against several unrelated drugs, and permeability glycoprotein derived from the overexpression of multidrug resistance gene 1 has been taken as the most significant cause of multidrug resistance. In the present study, ginsenoside Rh2 was used to reverse permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM cell line. Effects of ginsenoside Rh2 on the apoptotic process and caspase-3 activity of MCF-7 and MCF-7/ADM cell lines were determined using flow cytometry and microplate reader. Methyl thiazolyl tetrazolium test was conducted to assess the IC50 values of ginsenoside Rh2 and adriamycin on MCF-7 and MCF-7/ADM cultures; Rhodamin 123 assay was used to assess the retention of permeability glycoprotein after ginsenoside Rh2 treatment; flow cytometry and real time polymerase chain reaction were used to determine the expression levels of permeability glycoprotein and multidrug resistance gene 1 in drug-resistant cells and their parental cells after exposure to ginsenoside Rh2. The results showed that ginsenoside Rh2, except for inducing apoptosis, had the ability to reverse multidrug resistance in MCF-7/ADM cell line without changing the expression levels of permeability glycoprotein and multidrug resistance gene 1. Our findings provided some valuable information for the application of ginsenoside Rh2 in cancer therapy, especially for multidrug resistance reversal in clinic.

ADM. Warehouse (TAN604). Elevations and sections. Ralph M. Parsons 9022ANP604A ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Warehouse (TAN-604). Elevations and sections. Ralph M. Parsons 902-2-ANP-604-A 56. Date: December 1952. Approved by INEEL Classification Office for public release. INEEL index code no. 035-0604-00-693-106728 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Improvements, testing and development of the ADM-τ sub-grid surface tension model for two-phase LES

NASA Astrophysics Data System (ADS)

Aniszewski, Wojciech

2016-12-01

In this paper, a specific subgrid term occurring in Large Eddy Simulation (LES) of two-phase flows is investigated. This and other subgrid terms are presented, we subsequently elaborate on the existing models for those and re-formulate the ADM-τ model for sub-grid surface tension previously published by these authors. This paper presents a substantial, conceptual simplification over the original model version, accompanied by a decrease in its computational cost. At the same time, it addresses the issues the original model version faced, e.g. introduces non-isotropic applicability criteria based on resolved interface's principal curvature radii. Additionally, this paper introduces more throughout testing of the ADM-τ, in both simple and complex flows.

Custodial Services and Building Maint: Performance Objectives.

ERIC Educational Resources Information Center

Downing, Charles; And Others

Several intermediate performance objectives and corresponding criterion measures are listed for each of 14 terminal objectives for high school custodial service and building maintenance course (the third year of a 3-year program). The materials were developed for a 36-week course (3 hours daily) designed to prepare 12th graders with entry level…

Supporting Theory Building in Integrated Services Research

ERIC Educational Resources Information Center

Robinson, Mark; Atkinson, Mary; Downing, Dick

2008-01-01

This literature review was commissioned by the National Foundation for Educational Research (NFER) to draw together current and recent studies of integrated working, in order to build an overview of the theories and models of such working. The review is important for current work on evaluating the early impact of integrated children's services and…

Building a print on demand web service

NASA Astrophysics Data System (ADS)

Reddy, Prakash; Rozario, Benedict; Dudekula, Shariff; V, Anil Dev

2011-03-01

There is considerable effort underway to digitize all books that have ever been printed. There is need for a service that can take raw book scans and convert them into Print on Demand (POD) books. Such a service definitely augments the digitization effort and enables broader access to a wider audience. To make this service practical we have identified three key challenges that needed to be addressed. These are: a) produce high quality image images by eliminating artifacts that exist due to the age of the document or those that are introduced during the scanning process b) develop an efficient automated system to process book scans with minimum human intervention; and c) build an eco system which allows us the target audience to discover these books.

77 FR 38064 - Public Buildings Service; Information Collection; GSA Form 3453, Application/Permit for Use of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... Buildings Service; Information Collection; GSA Form 3453, Application/Permit for Use of Space in Public Buildings and Grounds AGENCY: Public Buildings Service, GSA. ACTION: Notice of request for comments... regarding GSA Form 3453, Application/Permit for Use of Space in Public Buildings and Grounds. Public...

41 CFR 105-53.147 - Public Buildings Service.

Code of Federal Regulations, 2013 CFR

2013-07-01

... for the design, construction, management, maintenance, operation, alteration, extension, remodeling... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Public Buildings Service. 105-53.147 Section 105-53.147 Public Contracts and Property Management Federal Property Management...

41 CFR 105-53.147 - Public Buildings Service.

Code of Federal Regulations, 2012 CFR

2012-01-01

... for the design, construction, management, maintenance, operation, alteration, extension, remodeling... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Public Buildings Service. 105-53.147 Section 105-53.147 Public Contracts and Property Management Federal Property Management...

41 CFR 105-53.147 - Public Buildings Service.

Code of Federal Regulations, 2011 CFR

2011-01-01

... for the design, construction, management, maintenance, operation, alteration, extension, remodeling... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Public Buildings Service. 105-53.147 Section 105-53.147 Public Contracts and Property Management Federal Property Management...

41 CFR 105-53.147 - Public Buildings Service.

Code of Federal Regulations, 2014 CFR

2014-01-01

... for the design, construction, management, maintenance, operation, alteration, extension, remodeling... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Public Buildings Service. 105-53.147 Section 105-53.147 Public Contracts and Property Management Federal Property Management...

In silico platform for xenobiotics ADME-T pharmacological properties modeling and prediction. Part II: The body in a Hilbertian space.

PubMed

Jacob, Alexandre; Pratuangdejkul, Jaturong; Buffet, Sébastien; Launay, Jean-Marie; Manivet, Philippe

2009-04-01

We have broken old surviving dogmas and concepts used in computational chemistry and created an efficient in silico ADME-T pharmacological properties modeling and prediction toolbox for any xenobiotic. With the help of an innovative and pragmatic approach combining various in silico techniques, like molecular modeling, quantum chemistry and in-house developed algorithms, the interactions between drugs and those enzymes, transporters and receptors involved in their biotransformation can be studied. ADME-T pharmacological parameters can then be predicted after in vitro and in vivo validations of in silico models.

76 FR 13329 - Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building Services

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

..., Release of Claims, for releases of claims under construction and building service contracts, was... prescribed the use of GSA Form 1142 for releases of claims under construction and building service contracts...] RIN 3090-AJ13 Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building...

41 CFR 105-53.147 - Public Buildings Service.

Code of Federal Regulations, 2010 CFR

2010-07-01

... of needed property management information systems for the Government; and coordination of GSA... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Public Buildings Service. 105-53.147 Section 105-53.147 Public Contracts and Property Management Federal Property Management...

The TRIAGE-ProADM Score for an Early Risk Stratification of Medical Patients in the Emergency Department - Development Based on a Multi-National, Prospective, Observational Study

PubMed Central

Hausfater, Pierre; Amin, Devendra; Amin, Adina; Canavaggio, Pauline; Sauvin, Gabrielle; Bernard, Maguy; Conca, Antoinette; Haubitz, Sebastian; Struja, Tristan; Huber, Andreas; Mueller, Beat; Schuetz, Philipp

2016-01-01

Introduction The inflammatory biomarker pro-adrenomedullin (ProADM) provides additional prognostic information for the risk stratification of general medical emergency department (ED) patients. The aim of this analysis was to develop a triage algorithm for improved prognostication and later use in an interventional trial. Methods We used data from the multi-national, prospective, observational TRIAGE trial including consecutive medical ED patients from Switzerland, France and the United States. We investigated triage effects when adding ProADM at two established cut-offs to a five-level ED triage score with respect to adverse clinical outcome. Results Mortality in the 6586 ED patients showed a step-wise, 25-fold increase from 0.6% to 4.5% and 15.4%, respectively, at the two ProADM cut-offs (≤0.75nmol/L, >0.75–1.5nmol/L, >1.5nmol/L, p ANOVA <0.0001). Risk stratification by combining ProADM within cut-off groups and the triage score resulted in the identification of 1662 patients (25.2% of the population) at a very low risk of mortality (0.3%, n = 5) and 425 patients (6.5% of the population) at very high risk of mortality (19.3%, n = 82). Risk estimation by using ProADM and the triage score from a logistic regression model allowed for a more accurate risk estimation in the whole population with a classification of 3255 patients (49.4% of the population) in the low risk group (0.3% mortality, n = 9) and 1673 (25.4% of the population) in the high-risk group (15.1% mortality, n = 252). Conclusions Within this large international multicenter study, a combined triage score based on ProADM and established triage scores allowed a more accurate mortality risk discrimination. The TRIAGE-ProADM score improved identification of both patients at the highest risk of mortality who may benefit from early therapeutic interventions (rule in), and low risk patients where deferred treatment without negatively affecting outcome may be possible (rule out). PMID:28005916

Insecticide ADME for support of early-phase discovery: combining classical and modern techniques.

PubMed

David, Michael D

2017-04-01

The two factors that determine an insecticide's potency are its binding to a target site (intrinsic activity) and the ability of its active form to reach the target site (bioavailability). Bioavailability is dictated by the compound's stability and transport kinetics, which are determined by both physical and biochemical characteristics. At BASF Global Insecticide Research, we characterize bioavailability in early research with an ADME (Absorption, Distribution, Metabolism and Excretion) approach, combining classical and modern techniques. For biochemical assessment of metabolism, we purify native insect enzymes using classical techniques, and recombinantly express individual insect enzymes that are known to be relevant in insecticide metabolism and resistance. For analytical characterization of an experimental insecticide and its metabolites, we conduct classical radiotracer translocation studies when a radiolabel is available. In discovery, where typically no radiolabel has been synthesized, we utilize modern high-resolution mass spectrometry to probe complex systems for the test compounds and its metabolites. By using these combined approaches, we can rapidly compare the ADME properties of sets of new experimental insecticides and aid in the design of structures with an improved potential to advance in the research pipeline. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

An overview of game-based learning in building services engineering education

NASA Astrophysics Data System (ADS)

Alanne, Kari

2016-03-01

To ensure proper competence development and short graduation times for engineering students, it is essential that the study motivation is encouraged by new learning methods. In game-based learning, the learner's engagement is increased and learning is made meaningful by applying game-like features such as competition and rewarding through virtual promotions or achievement badges. In this paper, the state of the art of game-based learning in building services engineering education at university level is reviewed and discussed. A systematic literature review indicates that educational games have been reported in the field of related disciplines, such as mechanical and civil engineering. The development of system-level educational games that realistically simulate work life in building services engineering is still in its infancy. Novel rewarding practices and more comprehensive approaches entailing the state-of-the-art information tools such as building information modelling, geographic information systems, building management systems and augmented reality are needed in the future.

ADM3, TFF3 and LGALS3 are discriminative molecular markers in fine-needle aspiration biopsies of benign and malignant thyroid tumours

PubMed Central

Karger, S; Krause, K; Gutknecht, M; Schierle, K; Graf, D; Steinert, F; Dralle, H; Führer, D

2012-01-01

Background: Previously, we reported a six-marker gene set, which allowed a molecular discrimination of benign and malignant thyroid tumours. Now, we evaluated these markers in fine-needle aspiration biopsies (FNAB) in a prospective, independent series of thyroid tumours with proven histological outcome. Methods: Quantitative RT–PCR was performed (ADM3, HGD1, LGALS3, PLAB, TFF3, TG) in the needle wash-out of 156 FNAB of follicular adenoma (FA), adenomatous nodules, follicular and papillary thyroid cancers (TC) and normal thyroid tissues (NT). Results: Significant expression differences were found for TFF3, HGD1, ADM3 and LGALS3 in FNAB of TC compared with benign thyroid nodules and NT. Using two-marker gene sets, a specific FNAB distinction of benign and malignant tumours was achieved with negative predictive values (NPV) up to 0.78 and positive predictive values (PPV) up to 0.84. Two FNAB marker gene combinations (ADM3/TFF3; ADM3/ACTB) allowed the distinction of FA and malignant follicular neoplasia with NPV up to 0.94 and PPV up to 0.86. Conclusion: We demonstrate that molecular FNAB diagnosis of benign and malignant thyroid tumours including follicular neoplasia is possible with recently identified marker gene combinations. We propose multi-centre FNAB studies on these markers to bring this promising diagnostic tool closer to clinical practice. PMID:22223087

How to report and discuss ADME data in medicinal chemistry publications: in vitro data or in vivo extrapolations?

PubMed

Svennebring, Andreas M

2015-01-01

Early drug discovery projects often utilize data from ADME (absorption, distribution, metabolism, elimination) assays to benchmark data and guide discussion, rather than the predicted in vivo consequences of these data. Here, the two paradigms are compared, using evaluations of metabolic stability based on either microsomal clearance assay data or from the predicted in vivo hepatic clearance and half-life calculated through the combination of the venous well-stirred model and Øie-Tozer's model. The need for a shift in paradigm is presented, and its implications discussed. It is suggested that discussions about ADME data should revolve around potential clinical problems that are most likely to surface during the development phase, each benchmarked with a suitable variable derived from the assay data.

77 FR 59925 - Public Buildings Service; Submission for OMB Review; Application/Permit for Use of Space in...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... Buildings Service; Submission for OMB Review; Application/ Permit for Use of Space in Public Buildings and Grounds, GSA Form 3453 AGENCY: Public Buildings Service, GSA. ACTION: Notice of request for comments... regarding GSA Form 3453, Application/Permit for Use of Space in Public Buildings and Grounds. A notice was...

20. Historic American Buildings Survey Photocopy from National Park Service ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Historic American Buildings Survey Photocopy from National Park Service files POTOMAC AQUEDUCT PIERS c. 1940 - Potomac Aqueduct, Georgetown abutment at Georgetown waterfront, Washington, District of Columbia, DC

PUS Services Software Building Block Automatic Generation for Space Missions

NASA Astrophysics Data System (ADS)

Candia, S.; Sgaramella, F.; Mele, G.

2008-08-01

The Packet Utilization Standard (PUS) has been specified by the European Committee for Space Standardization (ECSS) and issued as ECSS-E-70-41A to define the application-level interface between Ground Segments and Space Segments. The ECSS-E- 70-41A complements the ECSS-E-50 and the Consultative Committee for Space Data Systems (CCSDS) recommendations for packet telemetry and telecommand. The ECSS-E-70-41A characterizes the identified PUS Services from a functional point of view and the ECSS-E-70-31 standard specifies the rules for their mission-specific tailoring. The current on-board software design for a space mission implies the production of several PUS terminals, each providing a specific tailoring of the PUS services. The associated on-board software building blocks are developed independently, leading to very different design choices and implementations even when the mission tailoring requires very similar services (from the Ground operative perspective). In this scenario, the automatic production of the PUS services building blocks for a mission would be a way to optimize the overall mission economy and improve the robusteness and reliability of the on-board software and of the Ground-Space interactions. This paper presents the Space Software Italia (SSI) activities for the development of an integrated environment to support: the PUS services tailoring activity for a specific mission. the mission-specific PUS services configuration. the generation the UML model of the software building block implementing the mission-specific PUS services and the related source code, support documentation (software requirements, software architecture, test plans/procedures, operational manuals), and the TM/TC database. The paper deals with: (a) the project objectives, (b) the tailoring, configuration, and generation process, (c) the description of the environments supporting the process phases, (d) the characterization of the meta-model used for the generation, (e) the

REACTOR SERVICE BUILDING, TRA635. CROWDED MOCKUP AREA. CAMERA FACES EAST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

REACTOR SERVICE BUILDING, TRA-635. CROWDED MOCK-UP AREA. CAMERA FACES EAST. PHOTOGRAPHER'S NOTE SAYS "PICTURE REQUESTED BY IDO IN SUPPORT OF FY '58 BUILDING PROJECTS." INL NEGATIVE NO. 56-3025. R.G. Larsen, Photographer, 9/13/1956 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Available, intuitive and free! Building e-learning modules using web 2.0 services.

PubMed

Tam, Chun Wah Michael; Eastwood, Anne

2012-01-01

E-learning is part of the mainstream in medical education and often provides the most efficient and effective means of engaging learners in a particular topic. However, translating design and content ideas into a useable product can be technically challenging, especially in the absence of information technology (IT) support. There is little published literature on the use of web 2.0 services to build e-learning activities. To describe the web 2.0 tools and solutions employed to build the GP Synergy evidence-based medicine and critical appraisal online course. We used and integrated a number of free web 2.0 services including: Prezi, a web-based presentation platform; YouTube, a video sharing service; Google Docs, a online document platform; Tiny.cc, a URL shortening service; and Wordpress, a blogging platform. The course consisting of five multimedia-rich, tutorial-like modules was built without IT specialist assistance or specialised software. The web 2.0 services used were free. The course can be accessed with a modern web browser. Modern web 2.0 services remove many of the technical barriers for creating and sharing content on the internet. When used synergistically, these services can be a flexible and low-cost platform for building e-learning activities. They were a pragmatic solution in our context.

41 CFR 102-74.35 - What building services must Executive agencies provide?

Code of Federal Regulations, 2011 CFR

2011-01-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74... grounds maintenance, tenant alterations, minor repairs, building maintenance, integrated pest management... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What building services...

41 CFR 102-74.35 - What building services must Executive agencies provide?

Code of Federal Regulations, 2014 CFR

2014-01-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74... grounds maintenance, tenant alterations, minor repairs, building maintenance, integrated pest management... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What building services...

41 CFR 102-74.35 - What building services must Executive agencies provide?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74... grounds maintenance, tenant alterations, minor repairs, building maintenance, integrated pest management... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What building services...

41 CFR 102-74.35 - What building services must Executive agencies provide?

Code of Federal Regulations, 2012 CFR

2012-01-01

... Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74... grounds maintenance, tenant alterations, minor repairs, building maintenance, integrated pest management... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What building services...

[Provision of building maintenance services in healthcare facilities].

PubMed

Amorim, Gláucia Maria; Quintão, Eliana Cardoso Vieira; Martelli Júnior, Hercílio; Bonan, Paulo Rogério Ferreti

2013-01-01

The scope of this paper was to evaluate the provision of building maintenance services in health units, by means of a descriptive, quantitative and cross-sectional study, considering the five types of facilities (Primary Health, Emergency, Specialty, Hospital and Mental Health Units). The research was approved by the Research Ethics Comittee of FHEMIG with the Terms of Agreement signed with the Unified Health System of Betim. Comparative analysis was conducted by checking the requirements of "Physical-Functional Structure Management" of the "Brazilian Hospital Accreditation Manual" of the National Accreditation Organization. Nonconformities were noted in the physical-functional management of the health centers, especially the primary health units. The assessment was important, considering that compliance with formal, technical and structural requirements, welfare activities, according to the service organization and appropriate to the profile and complexity, can collaborate to minimize the risks of users. To improve the quality of health care establishments, it is essential that managers, backed by "top management," prioritize financial, human and material resources in planning to ensure compliance with security requirements of users in buildings.

Aerosol optical properties retrieved from the future space lidar mission ADM-aeolus

NASA Astrophysics Data System (ADS)

Martinet, Pauline; Flament, Thomas; Dabas, Alain

2018-04-01

The ADM-Aeolus mission, to be launched by end of 2017, will enable the retrieval of aerosol optical properties (extinction and backscatter coefficients essentially) for different atmospheric conditions. A newly developed feature finder (FF) algorithm enabling the detection of aerosol and cloud targets in the atmospheric scene has been implemented. Retrievals of aerosol properties at a better horizontal resolution based on the feature finder groups have shown an improvement mainly on the backscatter coefficient compared to the common 90 km product.

REACTOR SERVICES BUILDING, TRA635, INTERIOR. ALSO KNOWN AS MATERIAL RECEIVING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

REACTOR SERVICES BUILDING, TRA-635, INTERIOR. ALSO KNOWN AS MATERIAL RECEIVING AREA AND LABORATORY. CAMERA ON FIRST FLOOR FACING NORTH TOWARD MTR BUILDING. MOCK-UP AREA WAS TO THE RIGHT OF VIEW. INL NEGATIVE NO. HD46-10-1. Mike Crane, Photographer, 2/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Refocusing reference services outside the library building: one library's experience.

PubMed

Lubker, Irene M; Henderson, Margaret E; Canevari, Catharine S; Wright, Barbara A

2010-07-01

In response to changing user needs, the library sought ways to meet new challenges and engage users outside of the building. Librarians were removed from the service desk in order to offer support at locations around campus. The service desk in the library was staffed primarily by paraprofessionals with librarians providing support as needed. Targeted staff training was offered, and different scheduling models were used over a period of time. Restructuring the service desk was a complicated endeavor but provided a number of benefits including expansion of services. Along the way, challenges were met and recognized as learning opportunities.

ADM1-based methodology for the characterisation of the influent sludge in anaerobic reactors.

PubMed

Huete, E; de Gracia, M; Ayesa, E; Garcia-Heras, J L

2006-01-01

This paper presents a systematic methodology to characterise the influent sludge in terms of the ADM1 components from the experimental measurements traditionally used in wastewater engineering. For this purpose, a complete characterisation of the model components in their elemental mass fractions and charge has been used, making a rigorous mass balance for all the process transformations and enabling the future connection with other unit-process models. It also makes possible the application of mathematical algorithms for the optimal characterisation of several components poorly defined in the ADM1 report. Additionally, decay and disintegration have been necessarily uncoupled so that the decay proceeds directly to hydrolysis instead of producing intermediate composites. The proposed methodology has been applied to the particular experimental work of a pilot-scale CSTR treating real sewage sludge, a mixture of primary and secondary sludge. The results obtained have shown a good characterisation of the influent reflected in good model predictions. However, its limitations for an appropriate prediction of alkalinity and carbon percentages in biogas suggest the convenience of including the elemental characterisation of the process in terms of carbon in the analytical program.

VOLTTRON-Based System for Providing Ancillary Services with Residential Building Loads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, Xin

2016-07-01

Ancillary services entail controlled modulation of building equipment to maintain a stable balance of generation and load in the power system. Ancillary services include frequency regulation and contingency reserves, whose acting time ranges from several seconds to several minutes. Many pilot studies have been implemented to use industrial loads to provide ancillary services, and some have explored services from commercial building loads or electric vehicle charging loads. Residential loads, such as space conditioning and water heating, represent a largely untapped resource for providing ancillary services. The residential building sector accounts for a significant fraction of the total electricity use inmore » the United States. Many loads in residential buildings are flexible and could potentially be curtailed or shifted at the request of the grid. However, there are many barriers that prevent residential loads being widely used for ancillary services. One of the major technical barriers is the lack of communication capabilities between end-use devices and the grid. End-use devices need to be able to receive the automatic generation control (AGC) signal from the grid operator and supply certain types of telemetry to verify response. With the advance of consumer electronics, communication-enabled, or 'connected,' residential equipment has emerged to overcome the communication barrier. However, these end-use devices have introduced a new interoperability challenge due to the existence of numerous standards and communication protocols among different end devices. In this paper, we present a VOLTTRON-based system that overcomes these technical challenges and provides ancillary services with residential loads. VOLTTRON is an open-source control and sensing platform for building energy management, facilitating interoperability solutions for end devices. We have developed drivers to communicate and control different types of end devices through standard

A waste characterisation procedure for ADM1 implementation based on degradation kinetics.

PubMed

Girault, R; Bridoux, G; Nauleau, F; Poullain, C; Buffet, J; Steyer, J-P; Sadowski, A G; Béline, F

2012-09-01

In this study, a procedure accounting for degradation kinetics was developed to split the total COD of a substrate into each input state variable required for Anaerobic Digestion Model n°1. The procedure is based on the combination of batch experimental degradation tests ("anaerobic respirometry") and numerical interpretation of the results obtained (optimisation of the ADM1 input state variable set). The effects of the main operating parameters, such as the substrate to inoculum ratio in batch experiments and the origin of the inoculum, were investigated. Combined with biochemical fractionation of the total COD of substrates, this method enabled determination of an ADM1-consistent input state variable set for each substrate with affordable identifiability. The substrate to inoculum ratio in the batch experiments and the origin of the inoculum influenced input state variables. However, based on results modelled for a CSTR fed with the substrate concerned, these effects were not significant. Indeed, if the optimal ranges of these operational parameters are respected, uncertainty in COD fractionation is mainly limited to temporal variability of the properties of the substrates. As the method is based on kinetics and is easy to implement for a wide range of substrates, it is a very promising way to numerically predict the effect of design parameters on the efficiency of an anaerobic CSTR. This method thus promotes the use of modelling for the design and optimisation of anaerobic processes. Copyright © 2012 Elsevier Ltd. All rights reserved.

Building asynchronous geospatial processing workflows with web services

NASA Astrophysics Data System (ADS)

Zhao, Peisheng; Di, Liping; Yu, Genong

2012-02-01

Geoscience research and applications often involve a geospatial processing workflow. This workflow includes a sequence of operations that use a variety of tools to collect, translate, and analyze distributed heterogeneous geospatial data. Asynchronous mechanisms, by which clients initiate a request and then resume their processing without waiting for a response, are very useful for complicated workflows that take a long time to run. Geospatial contents and capabilities are increasingly becoming available online as interoperable Web services. This online availability significantly enhances the ability to use Web service chains to build distributed geospatial processing workflows. This paper focuses on how to orchestrate Web services for implementing asynchronous geospatial processing workflows. The theoretical bases for asynchronous Web services and workflows, including asynchrony patterns and message transmission, are examined to explore different asynchronous approaches to and architecture of workflow code for the support of asynchronous behavior. A sample geospatial processing workflow, issued by the Open Geospatial Consortium (OGC) Web Service, Phase 6 (OWS-6), is provided to illustrate the implementation of asynchronous geospatial processing workflows and the challenges in using Web Services Business Process Execution Language (WS-BPEL) to develop them.

LOFT. Containment and service building (TAN650). Section through east/west axis ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). Section through east/west axis of building as viewed from the south. Shows basement and grade levels of containment building, connection to control room on west side, air filter vaults, and duct enclosure for air exhaust system. Kaiser engineers 6413-11-STEP/LOFT-650-A-4. Date: October 1964. INEEL index code no. 036-650-00-486-122216 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling.

PubMed

Pham-The, Hai; Casañola-Martin, Gerardo; Garrigues, Teresa; Bermejo, Marival; González-Álvarez, Isabel; Nguyen-Hai, Nam; Cabrera-Pérez, Miguel Ángel; Le-Thi-Thu, Huong

2016-02-01

In many absorption, distribution, metabolism, and excretion (ADME) modeling problems, imbalanced data could negatively affect classification performance of machine learning algorithms. Solutions for handling imbalanced dataset have been proposed, but their application for ADME modeling tasks is underexplored. In this paper, various strategies including cost-sensitive learning and resampling methods were studied to tackle the moderate imbalance problem of a large Caco-2 cell permeability database. Simple physicochemical molecular descriptors were utilized for data modeling. Support vector machine classifiers were constructed and compared using multiple comparison tests. Results showed that the models developed on the basis of resampling strategies displayed better performance than the cost-sensitive classification models, especially in the case of oversampling data where misclassification rates for minority class have values of 0.11 and 0.14 for training and test set, respectively. A consensus model with enhanced applicability domain was subsequently constructed and showed improved performance. This model was used to predict a set of randomly selected high-permeability reference drugs according to the biopharmaceutics classification system. Overall, this study provides a comparison of numerous rebalancing strategies and displays the effectiveness of oversampling methods to deal with imbalanced permeability data problems.

Building Leadership Capacity in Early Childhood Pre-Service Teachers

ERIC Educational Resources Information Center

Campbell-Evans, Glenda; Stamopoulos, Elizabeth; Maloney, Carmel

2014-01-01

Building leadership capacity has emerged as a key concern within the early childhood profession in Australia as the sector responds to recent national reforms focusing on raising standards and improving quality provision of services. The purpose of this paper is to contribute to the discussion around these reforms and to make a case for changes…

Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway.

PubMed

Zhang, Xueyan; Ai, Ziying; Chen, Jing; Yi, Juan; Liu, Zhuan; Zhao, Huaishun; Wei, Hulai

2017-04-01

In human leukaemia, resistance to chemotherapy leads to treatment ineffectiveness or failure. Previous studies have indicated that cancers with increased levels of aerobic glycolysis are insensitive to numerous forms of chemotherapy and respond poorly to radiotherapy. Whether glycolysis serves a key role in drug resistance of leukaemia cells remains unclear. The present study systematically investigated aerobic glycolytic alterations and regulation in K562/adriamycin (ADM) multidrug‑resistant (MDR) and ADM‑sensitive K562 leukaemia cells in normoxia, and the association between drug resistance and improper glycometabolism. The cell proliferating activity was assessed with an MTT colorimetric assay, glycolysis, including glucose consumption, lactate export and key‑enzyme activity was determined by corresponding commercial testing kits. The expression levels of hexokinase‑II (HK‑II), lactate dehydrogenase A (LDHA), glucose transporter‑4 (GLUT‑4), AKT, p‑AKT473/308, mammalian target of rapamycin (mTOR), p‑mTOR, c‑Myc and hypoxia‑inducible factor‑1α (HIF‑1α) were analyzed by western blot or reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). K562/ADM cells exhibited increased glucose consumption and lactate accumulation, increased lactate dehydrogenase, hexokinase and pyruvate kinase activities, and reduced phosphofructokinase activity. In addition, K562/ADM cells expressed significantly more HK‑II and GLUT‑4. Notably, inhibition of glycolysis effectively killed sensitive and resistant leukaemia cells and potently restored the sensitivity of MDR cells to the anticancer agent ADM. The AKT serine/threonine kinase (AKT)/mechanistic target of rapamycin (mTOR) signalling pathway, a crucial regulator of glycometabolic homeostasis, mediated over‑activation and upregulation of c‑Myc expression levels in K562/ADM cells, which directly stimulated glucose consumption and enhanced glycolysis. In conclusion, the present

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma.

PubMed

Maia, Lucas de Lima; Peterle, Gabriela Tonini; Dos Santos, Marcelo; Trivilin, Leonardo Oliveira; Mendes, Suzanny Oliveira; de Oliveira, Mayara Mota; Dos Santos, Joaquim Gasparini; Stur, Elaine; Agostini, Lidiane Pignaton; Couto, Cinthia Vidal Monteiro da Silva; Dalbó, Juliana; de Assis, Aricia Leone Evangelista Monteiro; Archanjo, Anderson Barros; Mercante, Ana Maria Da Cunha; Lopez, Rossana Veronica Mendoza; Nunes, Fábio Daumas; de Carvalho, Marcos Brasilino; Tajara, Eloiza Helena; Louro, Iúri Drumond; Álvares-da-Silva, Adriana Madeira

2018-01-01

Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffin-embedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets.

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

PubMed Central

Peterle, Gabriela Tonini; dos Santos, Marcelo; Trivilin, Leonardo Oliveira; Mendes, Suzanny Oliveira; de Oliveira, Mayara Mota; dos Santos, Joaquim Gasparini; Stur, Elaine; Agostini, Lidiane Pignaton; Couto, Cinthia Vidal Monteiro da Silva; Dalbó, Juliana; de Assis, Aricia Leone Evangelista Monteiro; Archanjo, Anderson Barros; Mercante, Ana Maria Da Cunha; Lopez, Rossana Veronica Mendoza; Nunes, Fábio Daumas; de Carvalho, Marcos Brasilino; Tajara, Eloiza Helena; Louro, Iúri Drumond; Álvares-da-Silva, Adriana Madeira

2018-01-01

Aims Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffin-embedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets. PMID:29590186

Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for Pharmacogenomics

PubMed Central

2014-01-01

Background African Americans have been treated as a representative population for African ancestry for many purposes, including pharmacogenomic studies. However, the contribution of European ancestry is expected to result in considerable differences in the genetic architecture of African American individuals compared with an African genome. In particular, the genetic admixture influences the genomic diversity of drug metabolism-related genes, and may cause high heterogeneity of drug responses in admixed populations such as African Americans. Results The genomic ancestry information of African-American (ASW) samples was obtained from data of the 1000 Genomes Project, and local ancestral components were also extracted for 32 core genes and 252 extended genes, which are associated with drug absorption, distribution, metabolism, and excretion (ADME) genes. As expected, the global genetic diversity pattern in ASW was determined by the contributions of its putative ancestral source populations, and the whole profiles of ADME genes in ASW are much closer to those in YRI than in CEU. However, we observed much higher diversity in some functionally important ADME genes in ASW than either CEU or YRI, which could be a result of either genetic drift or natural selection, and we identified some signatures of the latter. We analyzed the clinically relevant polymorphic alleles and haplotypes, and found that 28 functional mutations (including 3 missense, 3 splice, and 22 regulator sites) exhibited significantly higher differentiation between the three populations. Conclusions Analysis of the genetic diversity of ADME genes showed differentiation between admixed population and its ancestral source populations. In particular, the different genetic diversity between ASW and YRI indicated that the ethnic differences in pharmacogenomic studies are broadly existed despite that African ancestry is dominant in Africans Americans. This study should advance our understanding of the genetic

ESA's spaceborne lidar mission ADM-Aeolus; project status and preparations for launch

NASA Astrophysics Data System (ADS)

Straume, Anne Grete; Elfving, Anders; Wernham, Denny; de Bruin, Frank; Kanitz, Thomas; Schuettemeyer, Dirk; Bismarck, Jonas von; Buscaglione, Fabio; Lecrenier, O.; McGoldrick, Phil

2018-04-01

ESA's Doppler Wind lidar mission, the Atmospheric Dynamics Mission (ADM-Aeolus, hereafter abbreviated to Aeolus), was chosen as an Earth Explorer Core mission within the Living Planet Programme in 1999. It shall demonstrate the potential of space-based Doppler Wind lidars for operational measurements of wind profiles and their use in Numerical Weather Prediction (NWP) and climate research. Spin-off products are profiles of cloud and aerosol optical properties. Aeolus carries the novel Doppler Wind lidar instrument ALADIN. The mission prime is Airbus Defence & Space UK (ADS-UK), and the instrument prime is Airbus Defence & Space France (ADS-F).

REACTOR SERVICE BUILDING, TRA635, INTERIOR. CAMERA FACES NORTHWEST TOWARDS INTERIOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

REACTOR SERVICE BUILDING, TRA-635, INTERIOR. CAMERA FACES NORTHWEST TOWARDS INTERIOR WALL ENCLOSING STORAGE AND OFFICE SPACE ALONG THE WEST SIDE. AT RIGHT EDGE IS DOOR TO MTR BUILDING. FROM RIGHT TO LEFT, SPACE WAS PLANNED FOR A LOCKER ROOM, MTR ISSUE ROOM, AND STORAGE AREAS AND RELATED OFFICES. NOTE SECOND "MEZZANINE" FLOOR ABOVE. INL NEGATIVE NO. 10227. Unknown Photographer, 3/23/1954 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Asset-building, financial self-management service model: piecing together consumer financial independence.

PubMed

Swarbrick, Margaret

2006-10-01

This program represents an innovative approach to traditional money-management services. This asset-building, financial self-management service model has the potential to positively affect recovery, self-sufficiency, and community integration for people with mental illnesses. It is hoped this program will be replicated by other providers in a way that may effect systems change.

School Buildings Services Information Needs Assessment: Volumes 1 and 2.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. School Buildings Services.

This report presents an information needs assessment for an office automation plan to be undertaken for the School Building Services Branch of the Alberta Department of Education. This exercise complements the work of two senior committees within the Department: (1) the Electronic Information Processing Needs Study Steering Committee, and (2) the…

IET control building (TAN620). interior personnel service room. sign next ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

IET control building (TAN-620). interior personnel service room. sign next to shower stall says, "fight athlete's foot with sani-mist." INEEL negative no. HD-21-1-1 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Can one ADM quantize relativistic bosonicstrings and membranes?

NASA Astrophysics Data System (ADS)

Moncrief, Vincent

2006-04-01

The standard methods for quantizing relativistic strings diverge significantly from the Dirac-Wheeler-DeWitt program for quantization of generally covariant systems and one wonders whether the latter could be successfully implemented as an alternative to the former. As a first step in this direction, we consider the possibility of quantizing strings (and also relativistic membranes) via a partially gauge-fixed ADM (Arnowitt, Deser and Misner) formulation of the reduced field equations for these systems. By exploiting some (Euclidean signature) Hamilton-Jacobi techniques that Mike Ryan and I had developed previously for the quantization of Bianchi IX cosmological models, I show how to construct Diff( S 1)-invariant (or Diff(Σ)-invariant in the case of membranes) ground state wave functionals for the cases of co-dimension one strings and membranes embedded in Minkowski spacetime. I also show that the reduced Hamiltonian density operators for these systems weakly commute when applied to physical (i.e. Diff( S 1) or Diff(Σ)-invariant) states. While many open questions remain, these preliminary results seem to encourage further research along the same lines.

Old Buildings Broadband Home Networks: Technologies and Services Overview

NASA Astrophysics Data System (ADS)

Fantacci, Romano; Pecorella, Tommaso; Micciullo, Luigia; Viti, Roberto; Pasquini, Vincenzo; Calì, Marco

2014-05-01

Internet broadband access is becoming a reality in many countries. To fully exploit the benefits from high-speed connection, both suitable home network connectivity and advanced services support have to be made available to the user. In this article, issues relative to the upgrade of existing home networks, particularly in old buildings, together with networking and security requirements are addressed, and possible solutions are proposed.

LOFT. Containment and service building (TAN650). Roof plan and details. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). Roof plan and details. Kaiser engineers 6413-11-STEP/LOFT-650-A-8. Date: October 1964. INEEL index code no. 036-650-00-486-122220 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Service-Learning Enriches Advertising Knowledge, Builds Students' Portfolios, and Promotes Community Engagement after Graduation

ERIC Educational Resources Information Center

Tucciarone, Krista

2012-01-01

This study investigated the influence of a service-learning component in an advertising course, specifically examining its ability to enrich advertising knowledge, build students' portfolios, and influence students' community engagement after graduation. The research revealed that service-learning positively affects students' understanding of…

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

PubMed Central

Daina, Antoine; Michielin, Olivier; Zoete, Vincent

2017-01-01

To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur. Drug development involves assessment of absorption, distribution, metabolism and excretion (ADME) increasingly earlier in the discovery process, at a stage when considered compounds are numerous but access to the physical samples is limited. In that context, computer models constitute valid alternatives to experiments. Here, we present the new SwissADME web tool that gives free access to a pool of fast yet robust predictive models for physicochemical properties, pharmacokinetics, drug-likeness and medicinal chemistry friendliness, among which in-house proficient methods such as the BOILED-Egg, iLOGP and Bioavailability Radar. Easy efficient input and interpretation are ensured thanks to a user-friendly interface through the login-free website http://www.swissadme.ch. Specialists, but also nonexpert in cheminformatics or computational chemistry can predict rapidly key parameters for a collection of molecules to support their drug discovery endeavours. PMID:28256516

Gatekeeping versus Promiscuity in the Early Stages of the Andrimid Biosynthetic Assembly Line

PubMed Central

Magarvey, Nathan A.; Fortin, Pascal D.; Thomas, Paul M.; Kelleher, Neil L.; Walsh, Christopher T.

2009-01-01

The antibiotic andrimid, a nanomolar inhibitor of bacterial acetyl coenzyme A carboxylase, is generated on an unusual polyketide/nonribosomal pep-tide enzyme assembly line in that all thiolation (T) domains/small-molecule building stations are on separate proteins. In addition, a transglutaminase homologue is used to condense andrimid building blocks together on the andrimid assembly line. The first two modules of the andrimid assembly line yields an octatrienoyl-β-Phe-thioester tethered to the AdmI T domain, with amide bond formation carried out by a free-standing transglutaminase homologue AdmF. Analysis of the aminomutase AdmH reveals its specific conversion from l-Phe to (S)-β-Phe, which in turn is activated by AdmJ and ATP to form (S)-β-Phe-aminoacyl-AMP. AdmJ then transfers the (S)-β-Phe moiety to one of the free-standing T domains, AdmI, but not AdmA, which instead gets loaded with an octatrienoyl group by other enzymes. AdmF, the amide synthase, will accept a variety of acyl groups in place of the octatrienoyl donor if presented on either AdmA or AdmI. AdmF will also use either stereoisomer of phenylalanine or β-Phe when presented on AdmA and AdmI, but not when placed on noncognate T domains. Further, we show the polyketide synthase proteins responsible for the polyunsaturated acyl cap can be bypassed in vitro with N-acetylcysteamine as a low-molecular-weight acyl donor to AdmF and also in vivo in an Escherichia coli strain bearing the andrimid biosynthetic gene cluster with a knockout in admA. PMID:18652473

LOFT. Containment and service building (TAN650). Section through east/west axis ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). Section through east/west axis of building as viewed from the north. Shows steel ladder to top of dome, gable roof of borated water tank enclosure, pumice block siding of pre-amp tower, metal siding of duct enclosure. Kaiser engineers 6413-11-STEP/LOFT-650-A-6. Date: October 1964. INEEL index code no. 036-650-00-486-122218 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Comparison of ADM and Connective Tissue Graft as the Membrane in Class II Furcation Defect Regeneration: A Randomized Clinical Trial

PubMed Central

Esfahanian, Vahid; Farhad, Shirin; Sadighi Shamami, Mehrnaz

2014-01-01

Background and aims. Furcally-involved teeth present unique challenges to the success of periodontal therapy and influence treatment outcomes. This study aimed to assess to compare use of ADM and connective tissue membrane in class II furcation defect regeneration. Materials and methods. 10 patient with 2 bilaterally class II furcation defects in first and/or second maxilla or man-dibular molar without interproximal furcation involvement, were selected. Four weeks after initial phase of treatment, before and thorough the surgery pocket depth (PD), clinical attachment level to stent (CAL-S), free gingival margin to stent(FGM-S) , crestal bone to stent (Crest-S), horizontal defect depth to stent (HDD-S) and vertical defect depth to stent (VDD-S) and crestal bone to defect depth measured from stent margin. Thereafter, one side randomly treated using connective tissue and DFDBA (study group) and opposite side received ADM and DFDBA (control group). After 6 months, soft and hard tissue parameters measured again in re-entry. Results. Both groups presented improvements after therapies (P & 0.05). No inter-group differences were seen in PD re-duction (P = 0.275), CAL gain (P = 0.156), free gingival margin (P = 0.146), crest of the bone (P = 0.248), reduction in horizontal defects depth (P = 0.139) and reduction in vertical defects depth (P = 0.149). Conclusion. Both treatments modalities have potential of regeneration without any adverse effect on healing process. Connective tissue grafts did not have significant higher bone fill compared to that of ADM. PMID:25093054

LOFT. Containment and service building (TAN650). Room number schedule, sheet ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). Room number schedule, sheet 2 of 2. Kaiser engineers 6413-11-STEP/LOFT-650-A-XX. Date: October 1969. INEEL index code no. 036-650-00-486-122228 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

The AskA Starter Kit: How To Build and Maintain Digital Reference Services.

ERIC Educational Resources Information Center

Lankes, R. David; Kasowitz, Abby S.

This Starter Kit is designed to help organizations and individuals who wish to offer human-mediated information services via the Internet to users in the K-12 community. A six-step process is proposed for organizations to follow in creating an "AskA" service. This process addresses all aspects involved in building and maintaining an AskA…

Building to Scale: An Analysis of Web-Based Services in CIC (Big Ten) Libraries.

ERIC Educational Resources Information Center

Dewey, Barbara I.

Advancing library services in large universities requires creative approaches for "building to scale." This is the case for CIC, Committee on Institutional Cooperation (Big Ten), libraries whose home institutions serve thousands of students, faculty, staff, and others. Developing virtual Web-based services is an increasingly viable…

160. ARAIII Service building (ARA610). Includes floor plan, north and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

160. ARA-III Service building (ARA-610). Includes floor plan, north and west elevations, and section details. Aerojet-general 880-area/GCRE-610-A-1. Date: February 1958. Ineel index code no. 063-0610-00-013-102684. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

LOFT. Containment and service building (TAN650). Sections H, K, and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). Sections H, K, and L; details of pre-amp tower. Kaiser engineers 6413-11-STEP/LOFT-650-A-14. Date: January 1966. INEEL index code no. 036-650-00-486-122226 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Building Culturally & Linguistically Competent Services to Support Young Children, Their Families, and School Readiness

ERIC Educational Resources Information Center

Hepburn, Kathy Seitzinger

2004-01-01

The purpose of this tool kit is to provide guidance, tools, and resources that will assist communities in building culturally and linguistically competent services, supports, programs, and practices related to young children, their families. By offering services in culturally and linguistically meaningful ways, communities can engage all families…

IET control building (TAN620). interior service area. equipment on concrete ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

IET control building (TAN-620). interior service area. equipment on concrete pads. liquid pump and valves on right. control panel at center of view, blower at left. piping for vent and sanitary sewer. INEEL negative no. HD-21-3-1 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Heat Treat Shop in the Technical Services Building

NASA Image and Video Library

1948-01-21

A technician prepares a metal component for a high-temperature bake in the Heat Treatment Shop at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory. Fabrication Division under Dan White and John Dalgleish created almost all of the equipment and models used at the laboratory. The Technical Services Building, referred to as the Fab Shop, contained a number of specialized shops in the 1940s and 1950s. These included a Machine Shop, Sheet Metal Shop, Wood and Pattern Shop, Instrument Shop, Thermocouple Shop, Heat Treating Shop, Metallurgical Laboratory, and Fabrication Office. The Metallurgical Laboratory contained a control lab for the Heat Treating Shop and a service lab for the NACA Lewis research divisions. This metallurgical group performed tensile and impact tests on metals to determine their suitability for specific research or equipment. The Heat Treating Shop heated metal parts to optimize their physical properties and contained a Precision Castings Foundry to manufacture equipment made of heat resisting alloys.

Advanced Development Model (ADM) Program for the Shipboard Meteorological and Oceanographic Observing System (SMOOS).

DTIC Science & Technology

1986-05-20

SOURCE DOCUMENTS 1. N62269-84- R -0309 SHOOS Request for Proposal (RFP) 2. N62269-84-C-0309, SOOS Advanced Development Model (ADM) Contract 3. SA-TS-7833...b.n . II ii t .. ~ r 5* t **v *...to, $me$ d.v.... 0", tc htlo I . .. vtod. - BT 9S.td Fig. 3.5- Susse Funtina AlloatinMtri ittnits 0~~~~~~4. vii...LSyes T ttiL e Request To r Transmit 9 Upper Air II aaDspDatalay *S Ocear Sea Depth I71 dg I Dept Data3ttu tts Data Display Data Display Controller

ETRMTR MECHANICAL SERVICES BUILDING, TRA653, INTERIOR. CAMERA IS INSIDE MEN'S ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR-MTR MECHANICAL SERVICES BUILDING, TRA-653, INTERIOR. CAMERA IS INSIDE MEN'S LAVATORY AND SHOWER FACING SOUTHEAST. SHOWER AND TOILET STALLS ARE IN PLACE. ROUND COMMUNAL SINK AT LEFT. INL NEGATIVE NO. 57-3652. K. Mansfield, Photographer, 7/22/1957 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

U.S. Fish and Wildlife Service Moves toward Net-Zero Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

First they had a vision: welcome people into a building embracing environmental stewardship on land that is steeped in history. The designers of the U.S. Fish and Wildlife Service took this vision and designed a new energy-efficient and environmentally friendly visitor center for the Assabet River National Wildlife Refuge located in Sudbury, Massachusetts.

LOFT, TAN650. Service building preamp tower, top three floors. Floor ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT, TAN-650. Service building pre-amp tower, top three floors. Floor plan, cable mazes, duct labyrinth. Borated water tank enclosure on roof. Kaiser engineers 6413-11-STEP/LOFT-650-A-3. Date: October 1964. INEEL index code no. 036-650-00-486-122215 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Investigations of VOCs in and around buildings close to service stations

NASA Astrophysics Data System (ADS)

Hicklin, William; Farrugia, Pierre S.; Sinagra, Emmanuel

2018-01-01

Gas service stations are one of the major sources of volatile organic compounds in urban environments. Their emissions are expected not only to affect the ambient air quality but also that in any nearby buildings. This is particularly the case in Malta where most service stations have been built within residential zones. For this reason, it is important to understand the dispersion of volatile organic compounds (VOCs) from service stations and their infiltration into nearby residences. Two models were considered; one to predict the dispersion of VOCs in the outdoor environment in the vicinity of the service station and another one to predict the filtration of the compounds indoors. The two models can be used in tandem to predict the concentration of indoor VOCs that originate from a service station in the vicinity. Outdoor and indoor concentrations of VOCs around a service station located in a street canyon were measured, and the results used to validate the models. Predictions made using the models were found to be in general agreement with the measured concentrations of the pollutants.

Fire Problems in High-Rise Buildings. California Fire Service Training Program.

ERIC Educational Resources Information Center

California State Dept. of Education, Sacramento. Bureau of Industrial Education.

Resulting from a conference concerned with high-rise fire problems, this manual has been prepared as a fire department training manual and as a reference for students enrolled in fire service training courses. Information is provided for topics dealing with: (1) Typical Fire Problems in High-Rise Buildings, (2) Heat, (3) Smoke and Fire Gases, (4)…

Building capacity in VA to provide emergency gynecology services for women.

PubMed

Cordasco, Kristina M; Huynh, Alexis K; Zephyrin, Laurie; Hamilton, Alison B; Lau-Herzberg, Amy E; Kessler, Chad S; Yano, Elizabeth M

2015-04-01

Visits to Veterans Administration (VA) emergency departments (EDs) are increasingly being made by women. A 2011 national inventory of VA emergency services for women revealed that many EDs have gaps in their resources and processes for gynecologic emergency care. To guide VA in addressing these gaps, we sought to understand factors acting as facilitators and/or barriers to improving VA ED capacity for, and quality of, emergency gynecology care. Semistructured interviews with VA emergency and women's health key informants. ED directors/providers (n=14), ED nurse managers (n=13), and Women Veteran Program Managers (n=13) in 13 VA facilities. Leadership, staff, space, demand, funding, policies, and community were noted as important factors influencing VA EDs building capacity and improving emergency gynecologic care for women Veterans. These factors are intertwined and cross multiple organizational levels so that each ED's capacity is a reflection not only of its own factors, but also those of its local medical center and non-VA community context as well as VA regional and national trends and policies. Policies and quality improvement initiatives aimed at building VA's emergency gynecologic services for women need to be multifactorial and aimed at multiple organizational levels. Policies need to be flexible to account for wide variations across EDs and their medical center and community contexts. Approaches that build and encourage local leadership engagement, such as evidence-based quality improvement methodology, are likely to be most effective.

A&M. Technical service laboratory in administration building (TAN602). Floor plan, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

A&M. Technical service laboratory in administration building (TAN-602). Floor plan, reception desk, door and finish schedules. Ralph M. Parsons 1480-12-ANP/GE-3-602-A-1. INEEL index code no. 033-0602-00-693-107488 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

LOFT. Containment and service building (TAN650) ground floor plan. Penetrations ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650) ground floor plan. Penetrations in dome wall. Shielded personnel maze at airlock door. Reactor chamber floor hatches and holddowns. Rails in concrete floor. Kaiser engineers 6413-11-STEP/LOFT-650-A-2. Date: October 1964. INEEL index code no. 036-650-00-486-122214 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

LOFT. Containment and service building (TAN650). Room number and function ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). Room number and function of each room. Identifies type of floor, paint, walls, ceiling, doors. This is sheet 1 of a 2-page drawing. Kaiser engineers 6413-11-STEP/LOFT-650-XX. Date: October 1965. INEEL index code no. 036-650-00-486-122228 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Evaluating capacity-building for mental health system strengthening in low- and middle-income countries for service users and caregivers, service planners and researchers.

PubMed

Hanlon, C; Semrau, M; Alem, A; Abayneh, S; Abdulmalik, J; Docrat, S; Evans-Lacko, S; Gureje, O; Jordans, M; Lempp, H; Mugisha, J; Petersen, I; Shidhaye, R; Thornicroft, G

2018-02-01

Efforts to support the scale-up of integrated mental health care in low- and middle-income countries (LMICs) need to focus on building human resource capacity in health system strengthening, as well as in the direct provision of mental health care. In a companion editorial, we describe a range of capacity-building activities that are being implemented by a multi-country research consortium (Emerald: Emerging mental health systems in low- and middle-income countries) for (1) service users and caregivers, (2) service planners and policy-makers and (3) researchers in six LMICs (Ethiopia, India, Nepal, Nigeria, South Africa and Uganda). In this paper, we focus on the methodology being used to evaluate the impact of capacity-building in these three target groups. We first review the evidence base for approaches to evaluation of capacity-building, highlighting the gaps in this area. We then describe the adaptation of best practice for the Emerald capacity-building evaluation. The resulting mixed method evaluation framework was tailored to each target group and to each country context. We identified a need to expand the evidence base on indicators of successful capacity-building across the different target groups. To address this, we developed an evaluation plan to measure the adequacy and usefulness of quantitative capacity-building indicators when compared with qualitative evaluation. We argue that evaluation needs to be an integral part of capacity-building activities and that expertise needs to be built in methods of evaluation. The Emerald evaluation provides a potential model for capacity-building evaluation across key stakeholder groups and promises to extend understanding of useful indicators of success.

Procurement of Architectural and Engineering Services for Sustainable Buildings: A Guide for Federal Project Managers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2004-06-01

This guide was prepared to be a resource for federal construction project managers and others who want to integrate the principles of sustainable design into the procurement of professional building design and consulting services. To economize on energy costs and improve the safety, comfort, and health of building occupants, building design teams can incorporate daylighting, energy efficiency, renewable energy, and passive solar design into all projects in which these elements are technically and economically feasible. The information presented here will help project leaders begin the process and manage the inclusion of sustainable design in the procurement process. The section onmore » establishing selection criteria contains key elements to consider before selecting an architectural and engineering (A/E) firm. The section on preparing the statement of work discusses the broad spectrum of sustainable design services that an A/E firm can provide. Several helpful checklists are included.« less

Renewable Electricity-to-Grid Integration | Energy Systems Integration

Science.gov Websites

distribution management system (ADMS) use cases at the ESIF's national, vendor-neutral ADMS test bed. Example use cases include: Integration of transmission-to-building operations for demand response

EPOS-Seismology: building the Thematic Core Service for Seismology during the EPOS Implementation Phase

NASA Astrophysics Data System (ADS)

Haslinger, Florian; EPOS Seismology Consortium, the

2015-04-01

After the successful completion of the EPOS Preparatory Phase, the community of European Research Infrastructures in Seismology is now moving ahead with the build-up of the Thematic Core Service (TCS) for Seismology in EPOS, EPOS-Seismology. Seismology is a domain where European-level infrastructures have been developed since decades, often supported by large-scale EU projects. Today these infrastructures provide services to access earthquake waveforms (ORFEUS), parameters (EMSC) and hazard data and products (EFEHR). The existing organizations constitute the backbone of infrastructures that also in future will continue to manage and host the services of the TCS EPOS-Seismology. While the governance and internal structure of these organizations will remain active, and continue to provide direct interaction with the community, EPOS-Seismology will provide the integration of these within EPOS. The main challenge in the build-up of the TCS EPOS-Seismology is to improve and extend these existing services, producing a single framework which is technically, organizationally and financially integrated with the EPOS architecture, and to further engage various kinds of end users (e.g. scientists, engineers, public managers, citizen scientists). On the technical side the focus lies on four major tasks: - the construction of the next generation software architecture for the European Integrated (waveform) Data Archive EIDA, developing advanced metadata and station information services, fully integrate strong motion waveforms and derived parametric engineering-domain data, and advancing the integration of mobile (temporary) networks and OBS deployments in EIDA; - the further development and expansion of services to access seismological products of scientific interest as provided by the community by implementing a common collection and development (IT) platform, improvements in the earthquake information services e.g. by introducing more robust quality indicators and diversifying

Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies.

PubMed

Ishida, Seiichi

2018-02-01

Assay systems using in vitro cultured cells are increasingly applied for evaluation of the efficacy, safety, and toxicity of drug candidates. In vitro cell-based assays have two main applications in the drug discovery process: searching for a compound that is effective against the target disease (seed investigation) and confirmation of safety during use of the identified compounds (safety assessment). Currently available in vitro cell-based assays have been designed to evaluate the efficacy and toxicity in single organs, but the in vivo pharmacokinetics and pharmacodynamics of the administered drug candidates have not been considered. Thus, an evaluation system that interconnects cell culture units, one of which has appropriate drug metabolism activities and the other assesses the efficacy and toxicity of compounds, is needed. Accordingly, the in vitro ADME-Tox culture system known as organs-on-a-chip has been proposed. In this review, after introducing the organs-on-a-chip system, the evaluation of enterohepatic circulation and the gut-liver axis relationship will be presented as an example of the application of the organs-on-a-chip system for ADME studies based on inter-organ network. Additionally, the functions required for the organs-on-a-chip system and the necessity of standardization of cells mounted on the chip system will be discussed. Copyright © 2018 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.

A Community Development Approach to Service-Learning: Building Social Capital between Rural Youth and Adults

ERIC Educational Resources Information Center

Henness, Steven A.; Ball, Anna L.; Moncheski, MaryJo

2013-01-01

Using 4-H and FFA case study findings, this article explores how community service-learning supports the building of social capital between rural youth and adults and the positive effects on community viability. Key elements of practice form a community development approach to service-learning, which opens up doorways for youth to partner with…

Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1.

PubMed

Yi, Ying-Jie; Jia, Xiu-Hong; Wang, Jian-Yong; Li, You-Jie; Wang, Hong; Xie, Shu-Yang

2016-05-01

Multidrug resistance (MDR) of leukemia cells is a major obstacle in chemotherapeutic treatment. The high expression and constitutive activation of P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP-1) have been reported to play a vital role in enhancing cell resistance to anticancer drugs in many tumors. The present study aimed to investigate the reversal of MDR by silencing homeobox A10 (HOXA10) in adriamycin (ADR)-resistant human chronic myelogenous leukemia (CML) K562/ADM cells by modulating the expression of P-gp and MRP-1. K562/ADM cells were stably transfected with HOXA10-targeted short hairpin RNA (shRNA). The results of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis showed that the mRNA and protein expression of HOXA10 was markedly suppressed following transfection with a shRNA-containing vector. The sensitivity of the K562/ADM cells to ADR was enhanced by the silencing of HOXA10, due to the increased intracellular accumulation of ADR. The accumulation of ADR induced by the silencing of HOXA10 may be due to the downregulation of P-gp and MRP-1. Western blot analysis revealed that downregulating HOXA10 inhibited the protein expression of P-gp and MRP-1. Taken together, these results suggest that knockdown of HOXA10 combats resistance and that HOXA10 is a potential target for resistant human CML.

Prediction of anaerobic biodegradability and bioaccessibility of municipal sludge by coupling sequential extractions with fluorescence spectroscopy: towards ADM1 variables characterization.

PubMed

Jimenez, Julie; Gonidec, Estelle; Cacho Rivero, Jesús Andrés; Latrille, Eric; Vedrenne, Fabien; Steyer, Jean-Philippe

2014-03-01

Advanced dynamic anaerobic digestion models, such as ADM1, require both detailed organic matter characterisation and intimate knowledge of the involved metabolic pathways. In the current study, a methodology for municipal sludge characterization is investigated to describe two key parameters: biodegradability and bioaccessibility of organic matter. The methodology is based on coupling sequential chemical extractions with 3D fluorescence spectroscopy. The use of increasingly strong solvents reveals different levels of organic matter accessibility and the spectroscopy measurement leads to a detailed characterisation of the organic matter. The results obtained from testing 52 municipal sludge samples (primary, secondary, digested and thermally treated) showed a successful correlation with sludge biodegradability and bioaccessibility. The two parameters, traditionally obtained through the biochemical methane potential (BMP) lab tests, are now obtain in only 5 days compared to the 30-60 days usually required. Experimental data, obtained from two different laboratory scale reactors, were used to validate the ADM1 model. The proposed approach showed a strong application potential for reactor design and advanced control of anaerobic digestion processes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Review of in-service moisture and temperature conditions in wood-frame buildings

Treesearch

Samuel V. Glass; Anton TenWolde

2007-01-01

This literature review reports in-service moisture and temperature conditions of floor, wall, and roof members of wood-frame buildings and exposed wood decks and permanent wood foundations. A wide variation exists in reported wood moisture content, spanning a range from as low as 2% to well above 30%. Relevant studies are summarized, and measured values of wood...

Application of the Software as a Service Model to the Control of Complex Building Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Donadee, Jonathan; Marnay, Chris

2011-03-17

In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building.more » The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analysed.« less

Application of the Software as a Service Model to the Control of Complex Building Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Donadee, Jon; Marnay, Chris

2011-03-18

In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building.more » The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analyzed.« less

An Experimental Study of Energy Consumption in Buildings Providing Ancillary Services

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Yashen; Afshari, Sina; Wolfe, John

Heating, ventilation, and air conditioning (HVAC) systems in commercial buildings can provide ancillary services (AS) to the power grid, but by providing AS their energy consumption may increase. This inefficiency is evaluated using round-trip efficiency (RTE), which is defined as the ratio between the decrease and the increase in the HVAC system's energy consumption compared to the baseline consumption as a result of providing AS. This paper evaluates the RTE of a 30,000 m2 commercial building providing AS. We propose two methods to estimate the HVAC system's settling time after an AS event based on temperature and the air flowmore » measurements from the building. Experimental data gathered over a 4-month period are used to calculate the RTE for AS signals of various waveforms, magnitudes, durations, and polarities. The results indicate that the settling time estimation algorithm based on the air flow measurements obtains more accurate results compared to the temperature-based algorithm. Further, we study the impact of the AS signal shape parameters on the RTE and discuss the practical implications of our findings.« less

75 FR 20598 - Public Buildings Service; Prospect Island, Sacramento Delta, Solano County, CA; Transfer of Property

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

... GENERAL SERVICES ADMINISTRATION [Wildlife Order 188; 9-I-CA-1674] Public Buildings Service; Prospect Island, Sacramento Delta, Solano County, CA; Transfer of Property Pursuant to section 2 of Public Law 537, 80th Congress, approved May 19, 1948 (16 U.S.C. 667c), notice is hereby given that: 1. The...

Optimal Coordination of Building Loads and Energy Storage for Power Grid and End User Services

DOE PAGES

Hao, He; Wu, Di; Lian, Jianming; ...

2017-01-18

Demand response and energy storage play a profound role in the smart grid. The focus of this study is to evaluate benefits of coordinating flexible loads and energy storage to provide power grid and end user services. We present a Generalized Battery Model (GBM) to describe the flexibility of building loads and energy storage. An optimization-based approach is proposed to characterize the parameters (power and energy limits) of the GBM for flexible building loads. We then develop optimal coordination algorithms to provide power grid and end user services such as energy arbitrage, frequency regulation, spinning reserve, as well as energymore » cost and demand charge reduction. Several case studies have been performed to demonstrate the efficacy of the GBM and coordination algorithms, and evaluate the benefits of using their flexibility for power grid and end user services. We show that optimal coordination yields significant cost savings and revenue. Moreover, the best option for power grid services is to provide energy arbitrage and frequency regulation. Finally and furthermore, when coordinating flexible loads with energy storage to provide end user services, it is recommended to consider demand charge in addition to time-of-use price in order to flatten the aggregate power profile.« less

Characterization of in Vitro ADME Properties of Diosgenin and Dioscin from Dioscorea villosa

PubMed Central

Manda, Vamshi K.; Avula, Bharathi; Ali, Zulfiqar; Wong, Yan-Hong; Smillie, Troy J.; Khan, Ikhlas A.; Khan, Shabana I.

2017-01-01

Dioscorea villosa (wild yam) is native to North America and has been widely used as a natural alternative for estrogen replacement therapy to improve women’s health as well as to treat inflammation, muscle spasm, and asthma. Diosgenin and dioscin (glycoside form of diosgenin) are reported to be the pharmacologically active compounds. Despite the reports of significant pharmacological properties of dioscin and diosgenin in conditions related to inflammation, cancer, diabetes, and gastrointestinal ailments, no reports are available on ADME properties of these compounds. This study was carried out to determine ADME properties of diosgenin and dioscin and their effects on major drug metabolizing enzymes (CYP 3A4, 2D6, 2C9, and 1A2). The stability was determined in simulated gastric and intestinal fluids (SGF, pH 1.2 and SIF, pH 6.8), and intestinal transport was evaluated in Caco-2 model. Phase I and phase II metabolic stability was determined in human liver microsomes and S9 fractions, respectively. Quantitative analysis of dioscin and diosgenin was performed by UPLC-MS system. Dioscin degraded up to 28.3% in SGF and 12.4% in SIF, which could be accounted for by its conversion to diosgenin (24.2%. in SGF and 2.4% in SIF). The depletion of diosgenin in SGF and SIF was < 10%. Diosgenin was stable in HLM but disappeared in S9 fraction with a half-life of 11.3 min. In contrast, dioscin was stable in both HLM and S9 fractions. Dioscin showed higher permeability across Caco-2 monolayer with no significant efflux, while diosgenin was subjected to efflux mediated by P-glycoprotein. Diosgenin and dioscin inhibited CYP3A4 with IC50 values of 17 and 33 μM, respectively, while other CYP enzymes were not affected. In conclusion, dioscin showed better intestinal permeability. Conversion of dioscin to diosgenin was observed in both gastric and intestinal fluids. No phase I metabolism was detected for both compounds. The disappearance of diosgenin in S9 fraction indicated phase II

LOFT. Containment and service building (TAN650). South elevation, details, section. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). South elevation, details, section. Shows part of duct enclosure, railroad door opening, roof ventilators, shielded personnel entrance, and change room. Section F shows view from west looking toward shielding around airlock door on main floor. Kaiser engineers 6413-11-STEP/LOFT-650-A-9. Date: October 1964. INEEL index code no. 036-650-00-486-122221 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

CoRes utilization for building PCK in pre-service teacher education on the digestive system topic

NASA Astrophysics Data System (ADS)

Nugraha, Ikmanda

2017-05-01

Knowledge of teachers in learning activities in the classroom has a close relationship with how well and how much students learn. Recently, a promising development in teacher education has appeared that centers on the academic construct of pedagogical content knowledge (PCK). This study was an exploratory study into a science teacher education program that seeks to build the foundations on which pre-service teachers can begin to build their pedagogical content knowledge (PCK). The program involved the use of Content Representations (CoRes), which was initially applied as component of a strategy for exploring and gaining insights into the PCK of in-service science teachers. This study involved the researcher and 20 students (third year) in a pre-service teacher education course (School Science I) in science education when the students worked to make content analysis on the digestive system topic. During the course, the students make their own CoRes through a workshop for digestive system topic individually, in pairs and whole class discussion. Data were recorded from students' CoRes, student reflective journals, interviews, and field notes recorded in the researcher's reflective journal. Pre-service teachers' comments from interviews and reflective journals were coded in relation to references about: (1) the effectiveness of variety strategies in building the knowledge bases required to design a CoRes and (2) their awareness and/or development of tentative components of future PCK for a digestive system topic as a result of CoRes construction. Observational data were examined for indications of increasing independence and competency on the part of student teachers when locating appropriate information for designing their CoRes. From this study, it is hoped that the pre-service science teachers are able to build knowledge and then transform it into a form of PCK for digestive system topic for their first classroom planning and teaching to teach digestive system

Building organizational supports for knowledge sharing in county human service organizations: a cross-case analysis of works-in-progress.

PubMed

Lee, Chris; Austin, Michael J

2012-01-01

Building on the literature related to evidence-based practice, knowledge management, and learning organizations, this cross-case analysis presents twelve works-in-progress in ten local public human service organizations seeking to develop their own knowledge sharing systems. The data for this cross-case analysis can be found in the various contributions to this Special Issue. The findings feature the developmental aspects of building a learning organization that include knowledge sharing systems featuring transparency, self-assessment, and dissemination and utilization. Implications for practice focus on the structure and processes involved in building knowledge sharing teams inside public human service organizations. Copyright © Taylor & Francis Group, LLC

Performance optimization and validation of ADM1 simulations under anaerobic thermophilic conditions.

PubMed

Atallah, Nabil M; El-Fadel, Mutasem; Ghanimeh, Sophia; Saikaly, Pascal; Abou-Najm, Majdi

2014-12-01

In this study, two experimental sets of data each involving two thermophilic anaerobic digesters treating food waste, were simulated using the Anaerobic Digestion Model No. 1 (ADM1). A sensitivity analysis was conducted, using both data sets of one digester, for parameter optimization based on five measured performance indicators: methane generation, pH, acetate, total COD, ammonia, and an equally weighted combination of the five indicators. The simulation results revealed that while optimization with respect to methane alone, a commonly adopted approach, succeeded in simulating methane experimental results, it predicted other intermediary outputs less accurately. On the other hand, the multi-objective optimization has the advantage of providing better results than methane optimization despite not capturing the intermediary output. The results from the parameter optimization were validated upon their independent application on the data sets of the second digester. Copyright © 2014 Elsevier Ltd. All rights reserved.

Reorienting health services with capacity building: a case study of the Core Skills in Health Promotion Project.

PubMed

Yeatman, H R; Nove, T

2002-12-01

This paper presents a case study of the application of a framework for capacity building [Hawe, P., King, L., Noort, M., Jordens, C. and Lloyd, B. (2000) Indicators to Help with Capacity Building in Health Promotion. NSW Health, Sydney] to describe actions aimed at building organizational support for health promotion within an area health service in New South Wales, Australia. The Core Skills in Health Promotion Project (CSHPP) arose from an investigation which reported that participants of a health promotion training course had increased health promotion skills but that they lacked the support to apply their skills in the workplace. The project was action-research based. It investigated and facilitated the implementation of a range of initiatives to support community health staff to apply a more preventive approach in their practice and it contributed to the establishment of new organizational structures for health promotion. An evaluation was undertaken 4 years after the CSHPP was established, and 2 years after it had submitted its final report. Interviews with senior managers, document analysis of written reports, and focus groups with middle managers and service delivery staff were undertaken. Change was achieved in the three dimensions of health infrastructure, program maintenance and problem solving capacity of the organization. It was identified that the critically important elements in achieving the aims of the project-partnership, leadership and commitment-were also key elements of the capacity building framework. This case study provides a practical example of the usefulness of the capacity building framework in orienting health services to be supportive of health promotion.

77 FR 58141 - Public Buildings Service; Information Collection; Art-in-Architecture Program National Artist...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-19

... Buildings Service; Information Collection; Art-in- Architecture Program National Artist Registry (GSA Form... regarding Art-in Architecture Program National Artist Registry (GSA Form 7437). The Art-in-Architecture...-Architecture & Fine Arts Division (PCAC), 1800 F Street NW., Room 3305, Washington, DC 20405, at telephone(202...

"Ayni" in the Global Village: Building Relationships of Reciprocity through International Service-Learning.

ERIC Educational Resources Information Center

Porter, Maureen; Monard, Kathia

2001-01-01

Uses the indigenous Andean concept of "ayni" to extend the idea of reciprocity as an aim of service learning. Draws on student reflections from a semester-long seminar with spring break building project in Bolivia to offer eight applications of the concept. These applications offer doorways to discuss the challenges of fostering mutual,…

Building Service Delivery Networks: Partnership Evolution Among Children's Behavioral Health Agencies in Response to New Funding.

PubMed

Bunger, Alicia C; Doogan, Nathan J; Cao, Yiwen

2014-12-01

Meeting the complex needs of youth with behavioral health problems requires a coordinated network of community-based agencies. Although fiscal scarcity or retrenchment can limit coordinated services, munificence can stimulate service delivery partnerships as agencies expand programs, hire staff, and spend more time coordinating services. This study examines the 2-year evolution of referral and staff expertise sharing networks in response to substantial new funding for services within a regional network of children's mental health organizations. Quantitative network survey data were collected from directors of 22 nonprofit organizations that receive funding from a county government-based behavioral health service fund. Both referral and staff expertise sharing networks changed over time, but results of a stochastic actor-oriented model of network dynamics suggest the nature of this change varies for these networks. Agencies with higher numbers of referral and staff expertise sharing partners tend to maintain these ties and/or develop new relationships over the 2 years. Agencies tend to refer to agencies they trust, but trust was not associated with staff expertise sharing ties. However, agencies maintain or form staff expertise sharing ties with referral partners, or with organizations that provide similar services. In addition, agencies tend to reciprocate staff expertise sharing, but not referrals. Findings suggest that during periods of resource munificence and service expansion, behavioral health organizations build service delivery partnerships in complex ways that build upon prior collaborative history and coordinate services among similar types of providers. Referral partnerships can pave the way for future information sharing relationships.

Cool Apps: Building Cryospheric Data Applications With Standards-Based Service Oriented Architecture

NASA Astrophysics Data System (ADS)

Collins, J. A.; Truslove, I.; Billingsley, B. W.; Oldenburg, J.; Brodzik, M.; Lewis, S.; Liu, M.

2012-12-01

The National Snow and Ice Data Center (NSIDC) holds a large collection of cryospheric data, and is involved in a number of informatics research and development projects aimed at improving the discoverability and accessibility of these data. To develop high-quality software in a timely manner, we have adopted a Service-Oriented Architecture (SOA) approach for our core technical infrastructure development. Data services at NSIDC are internally exposed to other tools and applications through standards-based service interfaces. These standards include OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting), various OGC (Open Geospatial Consortium) standards including WMS (Web Map Service) and WFS (Web Feature Service), ESIP (Federation of Earth Sciences Information Partners) OpenSearch, and NSIDC-specific RESTful services. By taking a standards-based approach, we are able to use off-the-shelf tools and libraries to consume, translate and broker these data services, and thus develop applications faster. Additionally, by exposing public interfaces to these services we provide valuable data services to technical collaborators; for example, NASA Reverb (http://reverb.echo.nasa.gov) uses NSIDC's WMS services. Our latest generation of web applications consume these data services directly. The most complete example of this is the Operation IceBridge Data Portal (http://nsidc.org/icebridge/portal) which depends on many of the aforementioned services, and clearly exhibits many of the advantages of building applications atop a service-oriented architecture. This presentation outlines the architectural approach and components and open standards and protocols adopted at NSIDC, demonstrates the interactions and uses of public and internal service interfaces currently powering applications including the IceBridge Data Portal, and outlines the benefits and challenges of this approach.

Developing capacity-building activities for mental health system strengthening in low- and middle-income countries for service users and caregivers, service planners, and researchers.

PubMed

Semrau, M; Alem, A; Abdulmalik, J; Docrat, S; Evans-Lacko, S; Gureje, O; Kigozi, F; Lempp, H; Lund, C; Petersen, I; Shidhaye, R; Thornicroft, G; Hanlon, C

2018-02-01

There is increasing international recognition of the need to build capacity to strengthen mental health systems. This is a fundamental goal of the 'Emerging mental health systems in low- and middle-income countries' (Emerald) programme, which is being implemented in six low- and middle-income countries (LMICs) (Ethiopia, India, Nepal, Nigeria, South Africa, Uganda). This paper discusses Emerald's capacity-building approaches and outputs for three target groups in mental health system strengthening: (1) mental health service users and caregivers, (2) service planners and policy-makers, and (3) mental health researchers. When planning the capacity-building activities, the approach taken included a capabilities/skills matrix, needs assessments, a situational analysis, systematic reviews, qualitative interviews and stakeholder meetings, as well as the application of previous theory, evidence and experience. Each of the Emerald LMIC partners was found to have strengths in aspects of mental health system strengthening, which were complementary across the consortium. Furthermore, despite similarities across the countries, capacity-building interventions needed to be tailored to suit the specific needs of individual countries. The capacity-building outputs include three publicly and freely available short courses/workshops in mental health system strengthening for each of the target groups, 27 Masters-level modules (also open access), nine Emerald-linked PhD students, two MSc studentships, mentoring of post-doctoral/mid-level researchers, and ongoing collaboration and dialogue with the three groups. The approach taken by Emerald can provide a potential model for the development of capacity-building activities across the three target groups in LMICs.

75 FR 20364 - Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... GENERAL SERVICES ADMINISTRATION [Wildlife Order 187; 4-D-FL-1218] Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property Pursuant to section 2 of Public Law 537, 80th Congress, approved May 19, 1948 (16 U.S.C. 667c), notice is hereby given that: 1. The General...

Inhibition of P-glycoprotein and glutathione S-transferase-pi mediated resistance by fluoxetine in MCF-7/ADM cells.

PubMed

Zhang, Ye; Zhou, Ting; Duan, Jingjing; Xiao, Zhijun; Li, Guihua; Xu, Feng

2013-10-01

Chemotherapy is important in the systematic treatment of breast cancer. While multidrug resistance (MDR) is the main obstacle in chemotherapy, a reversal reagent with high reversal effect but low toxicity is the hotspot issue at present to overcome MDR. Antidepressant fluoxetine (FLX) is a potential new highly effective chemosensitizer, however, the possible mechanism is unclear. In this study, the effect of FLX on multidrug resistance mediated by P-glycoprotein (P-gp) and glutathione S-transferase-pi (GST-π) were researched in resistant/sensitive breast cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to determine the cells viability after being incubated with FLX/Adriamycin (ADM)/Paclitaxel (PTX) alone or FLX-ADM, FLX-PTX combination. Western blot was performed to assay the expression of P-gp and GST-π proteins. Reverse transcriptase polymerase chain reaction (RT-PCR) and quantitative real-time PCR (qRT-PCR) were performed to assay the level of MDR1 mRNA. The results showed that pre-treatment with FLX enhance cytotoxicity significantly both on resistant and sensitive cells, downregulated the expression of P-gp and GST-π proteins in resistance cells, decreased the MDR1 mRNA by FLX-PTX combination only. No P-gp and GST-π were detected in sensitive cells. Our research thus indicated that FLX reverse the breast cancer cell's resistance and enhance the chemosensitivity by regulating P-gp and GST-π levels. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Measuring organizational flexibility in community pharmacy: Building the capacity to implement cognitive pharmaceutical services.

PubMed

Feletto, Eleonora; Wilson, Laura Kate; Roberts, Alison Sarah; Benrimoj, Shalom Isaac

2011-03-01

Community pharmacy is undergoing transformation with increasing pressure to build its capacity to deliver cognitive pharmaceutical services ("services"). The theoretical framework of organizational flexibility (OF) may be used to assess the capacity of community pharmacy to implement change programs and guide capacity-building initiatives. To test the applicability of an existing scale measuring OF to the industry of community pharmacy in Australia. A mail survey was used to test a preexisting scale measuring OF amended from 28 items to 20 items testing 3 underlying factors of operational, structural, and strategic flexibility in the Australian community pharmacy context. The sample was 2006 randomly-stratified community pharmacies. A confirmatory factor analysis was conducted to assess the validity and reliability of the 1-factor models for each underlying construct and the full measurement model. Responses were received from a total of 395 (19.7%) community pharmacies. The 1-factor models of operational, structural, and strategic flexibility fit the data with appropriate respecification. Overall, the favorable fit of the individual factor constructs suggested that the multiple-factor measurement model should be tested. However, this model did not yield an interpretable response. Operational flexibility covaried negatively to the other factors, whereas structural and strategic flexibility shared covariance. Despite this, the results highlighting the individual factor fit suggest the constructs have application to pharmacy. The individual OF constructs were useful in the development and initial testing of a scale adapted for community pharmacy. When further developed and validated, the scale could be used to identify group of pharmacies that require individualized assistance to build capacity and integrate services and other new endeavors. Copyright © 2011 Elsevier Inc. All rights reserved.

LOFT. Containment and service building (TAN650). Section through north/south axis. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOFT. Containment and service building (TAN-650). Section through north/south axis. Shows basement and four additional levels of pre-amp tower, shielded roadway, chambers below reactor floor, railroad door, sumps, shielding. Section C shows basement sumps and chambers below reactor floor. Kaiser engineers 6413-11-STEP/LOFT-650-A-5. Date: October 1964. INEEL index code no. 036-650-00-486-122217 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Building Interoperable FHIR-Based Vocabulary Mapping Services: A Case Study of OHDSI Vocabularies and Mappings.

PubMed

Jiang, Guoqian; Kiefer, Richard; Prud'hommeaux, Eric; Solbrig, Harold R

2017-01-01

The OHDSI Common Data Model (CDM) is a deep information model, in which its vocabulary component plays a critical role in enabling consistent coding and query of clinical data. The objective of the study is to create methods and tools to expose the OHDSI vocabularies and mappings as the vocabulary mapping services using two HL7 FHIR core terminology resources ConceptMap and ValueSet. We discuss the benefits and challenges in building the FHIR-based terminology services.

Public Library Service in Whitby. Part I, The Community, The Present Service and the Future. Part 2, A Building Programme.

ERIC Educational Resources Information Center

Bowron, Albert

A survey of the present service and future needs of the Whitby Public Library in Ontario, Canada was undertaken, and a new library building was planned. Part I describes the historical background of Whitby, the role of the present library in local history, the growth of the Town of Whitby from a population of 2,300 to 20,000, and the philosophy on…

Building Service Delivery Networks: Partnership Evolution Among Children’s Behavioral Health Agencies in Response to New Funding

PubMed Central

Bunger, Alicia C.; Doogan, Nathan J.; Cao, Yiwen

2014-01-01

Meeting the complex needs of youth with behavioral health problems requires a coordinated network of community-based agencies. Although fiscal scarcity or retrenchment can limit coordinated services, munificence can stimulate service delivery partnerships as agencies expand programs, hire staff, and spend more time coordinating services. This study examines the 2-year evolution of referral and staff expertise sharing networks in response to substantial new funding for services within a regional network of children’s mental health organizations. Quantitative network survey data were collected from directors of 22 nonprofit organizations that receive funding from a county government-based behavioral health service fund. Both referral and staff expertise sharing networks changed over time, but results of a stochastic actor-oriented model of network dynamics suggest the nature of this change varies for these networks. Agencies with higher numbers of referral and staff expertise sharing partners tend to maintain these ties and/or develop new relationships over the 2 years. Agencies tend to refer to agencies they trust, but trust was not associated with staff expertise sharing ties. However, agencies maintain or form staff expertise sharing ties with referral partners, or with organizations that provide similar services. In addition, agencies tend to reciprocate staff expertise sharing, but not referrals. Findings suggest that during periods of resource munificence and service expansion, behavioral health organizations build service delivery partnerships in complex ways that build upon prior collaborative history and coordinate services among similar types of providers. Referral partnerships can pave the way for future information sharing relationships. PMID:25574359

VPLS: an effective technology for building scalable transparent LAN services

NASA Astrophysics Data System (ADS)

Dong, Ximing; Yu, Shaohua

2005-02-01

Virtual Private LAN Service (VPLS) is generating considerable interest with enterprises and service providers as it offers multipoint transparent LAN service (TLS) over MPLS networks. This paper describes an effective technology - VPLS, which links virtual switch instances (VSIs) through MPLS to form an emulated Ethernet switch and build Scalable Transparent Lan Services. It first focuses on the architecture of VPLS with Ethernet bridging technique at the edge and MPLS at the core, then it tries to elucidate the data forwarding mechanism within VPLS domain, including learning and aging MAC addresses on a per LSP basis, flooding of unknown frames and replication for unknown, multicast, and broadcast frames. The loop-avoidance mechanism, known as split horizon forwarding, is also analyzed. Another important aspect of VPLS service is its basic operation, including autodiscovery and signaling, is discussed. From the perspective of efficiency and scalability the paper compares two important signaling mechanism, BGP and LDP, which are used to set up a PW between the PEs and bind the PWs to a particular VSI. With the extension of VPLS and the increase of full mesh of PWs between PE devices (n*(n-1)/2 PWs in all, a n2 complete problem), VPLS instance could have a large number of remote PE associations, resulting in an inefficient use of network bandwidth and system resources as the ingress PE has to replicate each frame and append MPLS labels for remote PE. So the latter part of this paper focuses on the scalability issue: the Hierarchical VPLS. Within the architecture of HVPLS, this paper addresses two ways to cope with a possibly large number of MAC addresses, which make VPLS operate more efficiently.

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639

PubMed Central

2015-01-01

The discovery of a novel peripherally acting and selective Cav3.2 T-type calcium channel blocker, ABT-639, is described. HTS hits 1 and 2, which have poor metabolic stability, were optimized to obtain 4, which has improved stability and oral bioavailability. Modification of 4 to further improve ADME properties led to the discovery of ABT-639. Following oral administration, ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. PMID:26101566

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.

PubMed

Zhang, Qingwei; Xia, Zhiren; Joshi, Shailen; Scott, Victoria E; Jarvis, Michael F

2015-06-11

The discovery of a novel peripherally acting and selective Cav3.2 T-type calcium channel blocker, ABT-639, is described. HTS hits 1 and 2, which have poor metabolic stability, were optimized to obtain 4, which has improved stability and oral bioavailability. Modification of 4 to further improve ADME properties led to the discovery of ABT-639. Following oral administration, ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.

Building 1100--NASA

NASA Technical Reports Server (NTRS)

1996-01-01

Building 1100 is the NASA administrative building. Services located in this building include two banks, a post office, barber shop, cafeteria, snack bar, travel agency, dry cleaners, the NASA Exchange retail store and medical facilities for employees.

VIEW LOOKING SOUTHWEST AT BUILDING 122 DURING CONSTRUCTION. BUILDING 122, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW LOOKING SOUTHWEST AT BUILDING 122 DURING CONSTRUCTION. BUILDING 122, THE EMERGENCY MEDICAL BUILDING, WAS ONE OF THE ORIGINAL STRUCTURES AT THE ROCKY FLATS PLANT. (5/29/52) - Rocky Flats Plant, Emergency Medical Services Facility, Southwest corner of Central & Third Avenues, Golden, Jefferson County, CO

FAST CHOPPER BUILDING, TRA665. CONTEXTUAL VIEW: CHOPPER BUILDING IN CENTER. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FAST CHOPPER BUILDING, TRA-665. CONTEXTUAL VIEW: CHOPPER BUILDING IN CENTER. MTR REACTOR SERVICES BUILDING,TRA-635, TO LEFT; MTR BUILDING TO RIGHT. CAMERA FACING WEST. INL NEGATIVE NO. HD42-1. Mike Crane, Photographer, 3/2004 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Building social capital with interprofessional student teams in rural settings: A service-learning model.

PubMed

Craig, Pippa L; Phillips, Christine; Hall, Sally

2016-08-01

To describe outcomes of a model of service learning in interprofessional learning (IPL) aimed at developing a sustainable model of training that also contributed to service strengthening. A total of 57 semi-structured interviews with key informants and document review exploring the impacts of interprofessional student teams engaged in locally relevant IPL activities. Six rural towns in South East New South Wales. Local facilitators, staff of local health and other services, health professionals who supervised the 89 students in 37 IPL teams, and academic and administrative staff. Perceived benefits as a consequence of interprofessional, service-learning interventions in these rural towns. Reported outcomes included increased local awareness of a particular issue addressed by the team; improved communication between different health professions; continued use of the team's product or a changed procedure in response to the teams' work; and evidence of improved use of a particular local health service. Given the limited workforce available in rural areas to supervise clinical IPL placements, a service-learning IPL model that aims to build social capital may be a useful educational model. © 2015 National Rural Health Alliance Inc.

75 FR 2144 - Public Buildings Service; Submission for OMB Review; Art-in-Architecture Program National Artist...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-14

... art from living American artists. One-half of one percent of the estimated construction cost of new or... for OMB Review; Art-in- Architecture Program National Artist Registry AGENCY: Public Buildings Service... extension of a previously approved information collection requirement regarding Art-in Architecture Program...

Using Multimedia Technology to Build a Community of Practice: Pre-Service Teachers' and Digital Storytelling in South Africa

ERIC Educational Resources Information Center

Chigona, Agnes

2013-01-01

Employing the theory of Community of Practice (CoP), this paper shows how the use of multimedia led a group of pre-service teachers to build a community of practice in the process of completing their individual digital stories for assessment. The paper is focused on a group of diverse pre-service teachers doing their final year at a teacher…

A Selective Bibliography of Building Environment and Service Systems with Particular Reference to Computer Applications. Computer Report CR20.

ERIC Educational Resources Information Center

Forwood, Bruce S.

This bibliography has been produced as part of a research program attempting to develop a new approach to building environment and service systems design using computer-aided design techniques. As such it not only classifies available literature on the service systems themselves, but also contains sections on the application of computers and…

Buildings interoperability landscape - Draft

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardin, Dave B.; Stephan, Eric G.; Wang, Weimin

2015-02-01

Buildings are an integral part of our nation’s energy economy. The advancement in information and communications technology (ICT) has revolutionized energy management in industrial facilities and large commercial buildings. As ICT costs decrease and capabilities increase, buildings automation and energy management features are transforming the small-medium commercial and residential buildings sectors. A vision of a connected world in which equipment and systems within buildings coordinate with each other to efficiently meet their owners’ and occupants’ needs, and where buildings regularly transact business with other buildings and service providers (such as gas and electric service providers) is emerging. However, while themore » technology to support this collaboration has been demonstrated at various degrees of maturity, the integration frameworks and ecosystems of products that support the ability to easily install, maintain, and evolve building systems and their equipment components are struggling to nurture the fledging business propositions of their proponents.« less

77 FR 73657 - Public Buildings Service; Submission for OMB Review; Art-in-Architecture Program National Artist...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... Buildings Service; Submission for OMB Review; Art-in- Architecture Program National Artist Registry (GSA... Architecture Program National Artist Registry (GSA Form 7437). A notice was published in the Federal Register at 77 FR 58141, on September 19, 2012. No comments were received. The Art-in-Architecture Program is...

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

PubMed

Schroeder, K; Bremm, K D; Alépée, N; Bessems, J G M; Blaauboer, B; Boehn, S N; Burek, C; Coecke, S; Gombau, L; Hewitt, N J; Heylings, J; Huwyler, J; Jaeger, M; Jagelavicius, M; Jarrett, N; Ketelslegers, H; Kocina, I; Koester, J; Kreysa, J; Note, R; Poth, A; Radtke, M; Rogiers, V; Scheel, J; Schulz, T; Steinkellner, H; Toeroek, M; Whelan, M; Winkler, P; Diembeck, W

2011-04-01

There are now numerous in vitro and in silico ADME alternatives to in vivo assays but how do different industries incorporate them into their decision tree approaches for risk assessment, bearing in mind that the chemicals tested are intended for widely varying purposes? The extent of the use of animal tests is mainly driven by regulations or by the lack of a suitable in vitro model. Therefore, what considerations are needed for alternative models and how can they be improved so that they can be used as part of the risk assessment process? To address these issues, the European Partnership for Alternative Approaches to Animal Testing (EPAA) working group on prioritization, promotion and implementation of the 3Rs research held a workshop in November, 2008 in Duesseldorf, Germany. Participants included different industry sectors such as pharmaceuticals, cosmetics, industrial- and agro-chemicals. This report describes the outcome of the discussions and recommendations (a) to reduce the number of animals used for determining the ADME properties of chemicals and (b) for considerations and actions regarding in vitro and in silico assays. These included: standardisation and promotion of in vitro assays so that they may become accepted by regulators; increased availability of industry in vivo kinetic data for a central database to increase the power of in silico predictions; expansion of the applicability domains of in vitro and in silico tools (which are not necessarily more applicable or even exclusive to one particular sector) and continued collaborations between regulators, academia and industry. A recommended immediate course of action was to establish an expert panel of users, developers and regulators to define the testing scope of models for different chemical classes. It was agreed by all participants that improvement and harmonization of alternative approaches is needed for all sectors and this will most effectively be achieved by stakeholders from different

77 FR 66616 - Office of Federal High-Performance Green Buildings; Green Building Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... Federal High-Performance Green Buildings; Green Building Advisory Committee; Notification of Upcoming... and agenda for the November 27, 2012, meeting of the Green Building Advisory Committee Meeting (the... Green Buildings, Office of Government-wide Policy, General Services Administration, 1275 First Street NE...

78 FR 21368 - Office of Federal High-Performance Green Buildings; Green Building Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... Federal High-Performance Green Buildings; Green Building Advisory Committee; Notification of Upcoming... and agenda for the May 1, 2013, meeting of the Green Building Advisory Committee Meeting (the... Green Buildings, Office of Government-wide Policy, General Services Administration, 1275 First Street NE...

Commercial Building Energy Asset Score

DOE Office of Scientific and Technical Information (OSTI.GOV)

This software (Asset Scoring Tool) is designed to help building owners and managers to gain insight into the as-built efficiency of their buildings. It is a web tool where users can enter their building information and obtain an asset score report. The asset score report consists of modeled building energy use (by end use and by fuel type), building systems (envelope, lighting, heating, cooling, service hot water) evaluations, and recommended energy efficiency measures. The intended users are building owners and operators who have limited knowledge of building energy efficiency. The scoring tool collects minimum building data (~20 data entries) frommore » users and build a full-scale energy model using the inference functionalities from Facility Energy Decision System (FEDS). The scoring tool runs real-time building energy simulation using EnergyPlus and performs life-cycle cost analysis using FEDS. An API is also under development to allow the third-party applications to exchange data with the web service of the scoring tool.« less

Exploring experiences in peer mentoring as a strategy for capacity building in sexual reproductive health and HIV service integration in Kenya

PubMed Central

2014-01-01

Background The Integra Initiative designed, tested, and adapted protocols for peer mentorship in order to improve service providers’ skills, knowledge, and capacity to provide quality integrated HIV and sexual and reproductive health (SRH) services. This paper describes providers’ experiences in mentoring as a method of capacity building. Service providers who were skilled in the provision of FP or PNC services were selected to undergo a mentorship training program and to subsequently build the capacity of their peers in SRH-HIV integration. Methods A qualitative assessment was conducted to assess provider experiences and perceptions about peer mentoring. In-depth interviews were conducted with twelve mentors and twenty-three mentees who were trained in SRH and HIV integration. Interviews were recorded, transcribed, and imported to NVivo 9 for analysis. Thematic analysis methods were used to develop a coding framework from the research questions and other emerging themes. Results Mentorship was perceived as a feasible and acceptable method of training among mentors and mentees. Both mentors and mentees agreed that the success of peer mentoring largely depended on cordial relationship and consensus to work together to achieve a specific set of skills. Mentees reported improved knowledge, skills, self-confidence, and team work in delivering integrated SRH and HIV services as benefits associated with mentoring. They also associated mentoring with an increase in the range of services available and the number of clients seeking those services. Successful mentorship was conditional upon facility management support, sufficient supplies and commodities, a positive work environment, and mentors selection. Conclusion Mentoring was perceived by both mentors and mentees as a sustainable method for capacity building, which increased providers’ ability to offer a wide range of and improved access to integrated SRH and HIV services. PMID:24581143

Exploring experiences in peer mentoring as a strategy for capacity building in sexual reproductive health and HIV service integration in Kenya.

PubMed

Ndwiga, Charity; Abuya, Timothy; Mutemwa, Richard; Kimani, James Kelly; Colombini, Manuela; Mayhew, Susannah; Baird, Averie; Muia, Ruth Wayua; Kivunaga, Jackline; Warren, Charlotte E

2014-03-01

The Integra Initiative designed, tested, and adapted protocols for peer mentorship in order to improve service providers' skills, knowledge, and capacity to provide quality integrated HIV and sexual and reproductive health (SRH) services. This paper describes providers' experiences in mentoring as a method of capacity building. Service providers who were skilled in the provision of FP or PNC services were selected to undergo a mentorship training program and to subsequently build the capacity of their peers in SRH-HIV integration. A qualitative assessment was conducted to assess provider experiences and perceptions about peer mentoring. In-depth interviews were conducted with twelve mentors and twenty-three mentees who were trained in SRH and HIV integration. Interviews were recorded, transcribed, and imported to NVivo 9 for analysis. Thematic analysis methods were used to develop a coding framework from the research questions and other emerging themes. Mentorship was perceived as a feasible and acceptable method of training among mentors and mentees. Both mentors and mentees agreed that the success of peer mentoring largely depended on cordial relationship and consensus to work together to achieve a specific set of skills. Mentees reported improved knowledge, skills, self-confidence, and team work in delivering integrated SRH and HIV services as benefits associated with mentoring. They also associated mentoring with an increase in the range of services available and the number of clients seeking those services. Successful mentorship was conditional upon facility management support, sufficient supplies and commodities, a positive work environment, and mentors selection. Mentoring was perceived by both mentors and mentees as a sustainable method for capacity building, which increased providers' ability to offer a wide range of and improved access to integrated SRH and HIV services.

Intelligent transportation systems Professional Capacity Building Program : framework and overview for establishing a professional capacity building program for transportation management and traveler information services in support of ITS deployment

DOT National Transportation Integrated Search

1997-09-30

This document has been prepared to describe how the U.S. Department of Transportations (US DOT) Five- Year Strategic Plan for Professional Capacity Building for ITS Transportation Management and Traveler Information Services is being implemented, ...

77 FR 2296 - Office of Federal High-Performance Green Buildings; the Green Building Advisory Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

... Federal High-Performance Green Buildings; the Green Building Advisory Committee; Notification of Upcoming... teleconference meetings of the Green Building Advisory Committee (the Committee). The teleconference meetings are... Federal High Performance Green Buildings, Office of Governmentwide Policy, General Services Administration...

The statistical evaluation and comparison of ADMS-Urban model for the prediction of nitrogen dioxide with air quality monitoring network.

PubMed

Dėdelė, Audrius; Miškinytė, Auksė

2015-09-01

In many countries, road traffic is one of the main sources of air pollution associated with adverse effects on human health and environment. Nitrogen dioxide (NO2) is considered to be a measure of traffic-related air pollution, with concentrations tending to be higher near highways, along busy roads, and in the city centers, and the exceedances are mainly observed at measurement stations located close to traffic. In order to assess the air quality in the city and the air pollution impact on public health, air quality models are used. However, firstly, before the model can be used for these purposes, it is important to evaluate the accuracy of the dispersion modelling as one of the most widely used method. The monitoring and dispersion modelling are two components of air quality monitoring system (AQMS), in which statistical comparison was made in this research. The evaluation of the Atmospheric Dispersion Modelling System (ADMS-Urban) was made by comparing monthly modelled NO2 concentrations with the data of continuous air quality monitoring stations in Kaunas city. The statistical measures of model performance were calculated for annual and monthly concentrations of NO2 for each monitoring station site. The spatial analysis was made using geographic information systems (GIS). The calculation of statistical parameters indicated a good ADMS-Urban model performance for the prediction of NO2. The results of this study showed that the agreement of modelled values and observations was better for traffic monitoring stations compared to the background and residential stations.

77 FR 43084 - Office of Federal High-Performance Green Buildings; Federal Buildings Personnel Training Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-23

... Federal High-Performance Green Buildings; Federal Buildings Personnel Training Act; Notification of... High- Performance Green Buildings, Office of Governmentwide Policy, General Services Administration... download from the Office of Federal High-Performance Green Building Web site Library at-- http://www.gsa...

Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery.

PubMed

Samiulla, D S; Vaidyanathan, V V; Arun, P C; Balan, G; Blaze, M; Bondre, S; Chandrasekhar, G; Gadakh, A; Kumar, R; Kharvi, G; Kim, H O; Kumar, S; Malikayil, J A; Moger, M; Mone, M K; Nagarjuna, P; Ogbu, C; Pendhalkar, D; Rao, A V S Raja; Rao, G Venkateshwar; Sarma, V K; Shaik, S; Sharma, G V R; Singh, S; Sreedhar, C; Sonawane, R; Timmanna, U; Hardy, L W

2005-01-01

Natural product analogs are significant sources for therapeutic agents. To capitalize efficiently on the effective features of naturally occurring substances, a natural product-based library production platform has been devised at Aurigene for drug lead discovery. This approach combines the attractive biological and physicochemical properties of natural product scaffolds, provided by eons of natural selection, with the chemical diversity available from parallel synthetic methods. Virtual property analysis, using computational methods described here, guides the selection of a set of natural product scaffolds that are both structurally diverse and likely to have favorable pharmacokinetic properties. The experimental characterization of several in vitro ADME properties of twenty of these scaffolds, and of a small set of designed congeners based upon one scaffold, is also described. These data confirm that most of the scaffolds and the designed library members have properties favorable to their utilization for creating libraries of lead-like molecules.

Sensitivity of predicted bioaerosol exposure from open windrow composting facilities to ADMS dispersion model parameters.

PubMed

Douglas, P; Tyrrel, S F; Kinnersley, R P; Whelan, M; Longhurst, P J; Walsh, K; Pollard, S J T; Drew, G H

2016-12-15

Bioaerosols are released in elevated quantities from composting facilities and are associated with negative health effects, although dose-response relationships are not well understood, and require improved exposure classification. Dispersion modelling has great potential to improve exposure classification, but has not yet been extensively used or validated in this context. We present a sensitivity analysis of the ADMS dispersion model specific to input parameter ranges relevant to bioaerosol emissions from open windrow composting. This analysis provides an aid for model calibration by prioritising parameter adjustment and targeting independent parameter estimation. Results showed that predicted exposure was most sensitive to the wet and dry deposition modules and the majority of parameters relating to emission source characteristics, including pollutant emission velocity, source geometry and source height. This research improves understanding of the accuracy of model input data required to provide more reliable exposure predictions. Copyright © 2016. Published by Elsevier Ltd.

Building the Capacity of Indonesian Education Universities for ICT in Pre-Service Teacher Education: A Case Study of a Strategic Planning Exercise

ERIC Educational Resources Information Center

Lim, Cher Ping; Pannen, Paulina

2012-01-01

This paper documents how four Indonesian teacher education institutions (TEIs) engaged in strategic planning to build their capacity in developing pre-service teachers' ICT in education competencies. These TEIs adopted a holistic approach towards strategic planning by drawing upon the six dimensions of the "Capacity Building Toolkit" for…

GPS Space Service Volume: Ensuring Consistent Utility Across GPS Design Builds for Space Users

NASA Technical Reports Server (NTRS)

Bauer, Frank H.; Parker, Joel Jefferson Konkl; Valdez, Jennifer Ellen

2015-01-01

GPS availability and signal strength originally specified for users on or near surface of Earth with transmitted power levels specified at edge-of-Earth, 14.3 degrees. Prior to the SSV specification, on-orbit performance of GPS varied from block build to block build (IIA, IIRM, IIF) due to antenna gain and beam width variances. Unstable on-orbit performance results in significant risk to space users. Side-lobe signals, although not specified, were expected to significantly boost GPS signal availability for users above the constellation. During GPS III Phase A, NASA noted significant discrepancies in power levels specified in GPS III specification documents, and measured on-orbit performance. To stabilize the signal for high altitude space users, NASA DoD team in 2003-2005 led the creation of new Space Service Volume (SSV) definition and specifications.

Child Care Services and the NYS Uniform Fire Prevention and Building Code: A Building Code Examination of Child Day Care Services Which Are Regulated by the NYS Department of Social Services with Particular Attention to Day Care Centers and the Role of the Local Authority Having Jurisdiction.

ERIC Educational Resources Information Center

New York State Div. of Code Enforcement and Administration, Albany.

This course manual details the Uniform Fire Prevention and Building Code of New York State and how it affects child care services, particularly day care centers. The sections of the manual, each detailing a part of the code, are: (1) Introduction, Scope, Registration, and Definitions and Facilities Regulated by the New York Department of Social…

The impact of the different payment options on the medical services clients' satisfaction building process

NASA Astrophysics Data System (ADS)

Skowron, Łukasz; Gąsior, Marcin; Sak-Skowron, Monika

2014-12-01

Both the scientific bodies as well as business practitioners over the past few years have concentrated their efforts in the field of marketing and management primarily around the concept of customer, wanting to know more about him/her and trying to understand their behaviour so that their market activities can more easily be influenced and shaped. In today's market, the customer bases the purchase-decision-making process on choosing a good/service that will give him/her the greatest satisfaction, a subjective, positive experience, which is an emotional reaction to the perceived value. Its level is a result of the comparison between the level of expectations arising from past experience, obtained information and promises, and the perception of experienced situation. In the empirical part of the manuscript, the authors present the main differences in the process of building customer satisfaction and loyalty for two groups of patients: those using prepaid medical services and those who pay for their services each time. Reported results refer to research carried out by the authors between August and October 2012 in the city of Warsaw (Poland) with use of the Structural Equation Modeling analysis. The study was conducted via paper surveys, on a sample of 1590 respondents who were the patients of selected medical organizations. The study demonstrated, using two, separate models, that among aforementioned groups of patients, the evaluation of health services proceeds in quite a different way. This indicates significant implications, of marketing and management character in the field of communication and building long-term patient-organization relationships. Medical establishments wanting to manage effectively their relationships with current and potential customers need to understand the nature of the different groups of patients and be able to adjust the scope and form of marketing activities to their different expectations and preferences.

Accessing Geospatial Services in Limited Bandwidth Service-Oriented Architecture (SOA) Environments

ERIC Educational Resources Information Center

Boggs, James D.

2013-01-01

First responders are continuously moving at an incident site and this movement requires them to access Service-Oriented Architecture services, such as a Web Map Service, via mobile wireless networks. First responders from inside a building often have problems in communicating to devices outside that building due to propagation obstacles. Dynamic…

The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.

PubMed

Johänning, Janina; Kröner, Patrick; Thomas, Maria; Zanger, Ulrich M; Nörenberg, Astrid; Eichelbaum, Michel; Schwab, Matthias; Brauch, Hiltrud; Schroth, Werner; Mürdter, Thomas E

2018-03-01

Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact. Thus, we characterized the estrogen-like metabolites tamoxifen bisphenol and metabolite E for their metabolic pathway and their influence on cytochrome P450 activity and ADME gene expression. The formation of tamoxifen bisphenol and metabolite E was studied in human liver microsomes and Supersomes™. Cellular metabolism and impact on CYP enzymes was analyzed in upcyte® hepatocytes. The influence of 5 µM of tamoxifen, anti-estrogenic and estrogen-like metabolites on CYP activity was measured by HPLC MS/MS and on ADME gene expression using RT-PCR analyses. Metabolite E was formed from tamoxifen by CYP2C19, 3A and 1A2 and from desmethyltamoxifen by CYP2D6, 1A2 and 3A. Tamoxifen bisphenol was mainly formed from (E)- and (Z)-metabolite E by CYP2B6 and CYP2C19, respectively. Regarding phase II metabolism, UGT2B7, 1A8 and 1A3 showed highest activity in glucuronidation of tamoxifen bisphenol and metabolite E. Anti-estrogenic metabolites (Z)-4-hydroxytamoxifen, (Z)-endoxifen and (Z)-norendoxifen inhibited the activity of CYP2C enzymes while tamoxifen bisphenol consistently induced CYPs similar to rifampicin and phenobarbital. On the transcript level, highest induction up to 5.6-fold was observed for CYP3A4 by tamoxifen, (Z)-4-hydroxytamoxifen, tamoxifen bisphenol and (E)-metabolite E. Estrogen-like tamoxifen metabolites are formed in CYP-dependent reactions and are further metabolized by glucuronidation. The induction of CYP activity by tamoxifen bisphenol and the inhibition of CYP2C enzymes by anti-estrogenic metabolites may lead to drug-drug-interactions.

The Intelcities Community of Practice: The Capacity-Building, Co-Design, Evaluation, and Monitoring of E-Government Services

ERIC Educational Resources Information Center

Deakin, Mark; Lombardi, Patrizia; Cooper, Ian

2011-01-01

The paper examines the IntelCities Community of Practice (CoP) supporting the development of the organization's capacity-building, co-design, monitoring, and evaluation of e-government services. It begins by outlining the IntelCities CoP and goes on to set out the integrated model of electronically enhanced government (e-government) services…

Administration Building Lobby

NASA Image and Video Library

1943-07-21

Receptionist Mary Louise Gosney enjoys the new Administration Building at the NACA’s Aircraft Engine Research Laboratory. The Administration Building, which was located near the front entrance to the laboratory, opened in December 1942. The staff, which had spent the previous year working in temporary offices inside the hangar, quickly occupied the new building. Lab director Raymond Sharp, the upper management team, and administrative staff had offices in the Administration Building. The structure also contained the lab’s library and auditorium. Gosney was a Chicago native who started at the lab in November 1941. Gosney’s services included welcoming visitors, arranging tours, and arranging interviews with staff members. Gosney’s “Lobby Lines” column in the lab’s newsletter Wing Tips noted the coming and goings of notable visitors and staff members. In addition to her role as receptionist, Gosney also served as the clearance officer. She would later head the entire Administrative Services Division.

Advancing indigent healthcare services through adaptive reuse: repurposing abandoned buildings as medical clinics for disadvantaged populations.

PubMed

Elrod, James K; Fortenberry, John L

2017-12-13

Challenges abound for healthcare providers engaged in initiatives directed toward disadvantaged populations, with financial constraints representing one of the most prominent hardships. Society's less fortunate typically lack the means to pay for healthcare services and even when they are covered by government health insurance programs, reimbursement shortcomings often occur, placing funding burdens on the shoulders of establishments dedicated to serving those of limited means. For such charitably-minded organizations, efficiencies are required on all fronts, including one which involves significant operational costs: the physical space required for care provision. Newly constructed buildings, whether owned or leased, are expensive, consuming a significant percentage of funds that otherwise could be directed toward patient care. Such costs can even prohibit the delivery of services to indigent populations altogether. But through adaptive reuse-the practice of repurposing existing, abandoned buildings, placing them back into service in pursuit of new missions-opportunities exist to economize on this front, allowing healthcare providers to acquire operational space at a discount. In an effort to shore up related knowledge, this article profiles Willis-Knighton Health System's development of Project NeighborHealth, an indigent clinic network which was significantly bolstered by the economies associated with adaptive reuse. Despite its potential to bolster healthcare initiatives directed toward the medically underserved by presenting more affordable options for acquiring operational space, adaptive reuse remains relatively obscure, diminishing opportunities for providers to take advantage of its many benefits. By shedding light on this repurposing approach, healthcare providers will have a better understanding of adaptive reuse, enabling them to make use of the practice to improve the depth and breadth of healthcare services available to disadvantaged populations.

Probation as a setting for building well-being through integrated service provision: evaluating an Offender Health Trainer service.

PubMed

Dooris, Mark; McArt, Dervla; Hurley, Margaret A; Baybutt, Michelle

2013-07-01

The NHS Health Trainer Programme was launched in England and Wales in 2005 with the aim of tackling health inequalities. While initially focusing on geographical communities, the initiative has extended its reach to particular population groups, such as offenders and their families, who experience high levels of physical and mental health needs and wider social exclusion. This paper reports on the evaluation of the Offender Health Trainer service delivered in probation settings in Bury, Rochdale and Oldham (Greater Manchester). This service has sought to improve the health of offenders, improve their access to mainstream services, and help reduce health inequalities - as well as facilitate rehabilitation and improve job prospects for ex-offenders through employment as health trainers. This evaluative research study aimed to explore the delivery of the Offender Health Trainer service and examine its impact on service users. The study design and limited time frame meant that the research was focused on the journeys of service users rather than on long-term outcomes. The evaluation used a mixed-methods approach, comprising two key elements: the interrogation and analysis of routinely collected quantitative data extracted from the National Health Trainer Data Collection Recording System (DCRS); and in-depth qualitative research using interviews and focus groups with clients and health trainers. The evaluation points to the overall success of the service in meeting its aims and impacting positively on the lives of offenders. It reveals promising trends in behaviour change and self-perceived health and well-being, articulating a rich narrative detailing how the service has helped probation clients tackle multiple interwoven problems and build hope and self-belief. Of particular importance was the health trainers' experience of the criminal justice system, which resonated with and inspired clients, developing trust and motivation to change. While the research inevitably

Building thematic and integrated services for solid Earth sciences: the EPOS integrated approach

NASA Astrophysics Data System (ADS)

Cocco, Massimo; Consortium, Epos

2016-04-01

EPOS has been designed with the vision of creating a pan-European infrastructure for solid Earth science to support a safe and sustainable society. In accordance with this scientific vision, the EPOS mission is to integrate the diverse and advanced European Research Infrastructures for solid Earth science relying on new e-science opportunities to monitor and unravel the dynamic and complex Earth System. EPOS will enable innovative multidisciplinary research for a better understanding of the Earth's physical and chemical processes that control earthquakes, volcanic eruptions, ground instability and tsunami as well as the processes driving tectonics and Earth's surface dynamics. To accomplish its mission, EPOS is engaging different stakeholders, not limited to scientists, to allow the Earth sciences to open new horizons in our understanding of the planet. EPOS also aims at contributing to prepare society for geo-hazards and to responsibly manage the exploitation of geo-resources. Through integration of data, models and facilities, EPOS will allow the Earth science community to make a step change in developing new concepts and tools for key answers to scientific and socio-economic questions concerning geo-hazards and geo-resources as well as Earth sciences applications to the environment and human welfare. A long-term integration plan is necessary to accomplish the EPOS mission. EPOS is presently in its implementation phase further extending its pan-European dimension. The EPOS Implementation Phase builds on the achievements of the successful EPOS Preparatory Phase project and consists of two key activities: the legal establishment of the EPOS-ERIC and the EPOS IP project. The EPOS implementation phase will last from 2015 to 2019. Key objectives of the project are: implementing Thematic Core Services (TCS), the domain-specific service hubs for coordinating and harmonizing national resources/plans with the European dimension of EPOS; building the Integrated Core

Building-to-Grid Integration through Commercial Building Portfolios Participating in Energy and Frequency Regulation Markets

NASA Astrophysics Data System (ADS)

Pavlak, Gregory S.

Building energy use is a significant contributing factor to growing worldwide energy demands. In pursuit of a sustainable energy future, commercial building operations must be intelligently integrated with the electric system to increase efficiency and enable renewable generation. Toward this end, a model-based methodology was developed to estimate the capability of commercial buildings to participate in frequency regulation ancillary service markets. This methodology was integrated into a supervisory model predictive controller to optimize building operation in consideration of energy prices, demand charges, and ancillary service revenue. The supervisory control problem was extended to building portfolios to evaluate opportunities for synergistic effect among multiple, centrally-optimized buildings. Simulation studies performed showed that the multi-market optimization was able to determine appropriate opportunities for buildings to provide frequency regulation. Total savings were increased by up to thirteen percentage points, depending on the simulation case. Furthermore, optimizing buildings as a portfolio achieved up to seven additional percentage points of savings, depending on the case. Enhanced energy and cost savings opportunities were observed by taking the novel perspective of optimizing building portfolios in multiple grid markets, motivating future pursuits of advanced control paradigms that enable a more intelligent electric grid.

The Building Bridges project: Linking disconnected service networks in acquired brain injury and criminal justice.

PubMed

Kelly, Glenn; Brown, Suzanne; Simpson, Grahame K

2018-06-08

People with acquired brain injury (ABI) are overrepresented in prison populations across many countries. An effective service response to reduce this trend requires collaboration between the ABI and criminal justice (CJ) sectors. The Building Bridges project piloted a novel professional development model designed to increase cross-sectoral knowledge and collaboration between the ABI and CJ sectors. A total of 178 service providers from Victoria, Australia, participated in six professional development forums that included content about ABI, policing, disability and legal supports, and correctional/post-release services. Participants came from the disability, criminal justice, and health and community service sectors. Using a pre-test-post-test design with 6-month follow-up, data were obtained via a project-specific questionnaire evaluating knowledge and behaviour change among participants. Statistically significant gains in knowledge were shown at post-test and maintained at follow-up. Work-related behaviours addressing ABI/CJ issues had increased significantly within both sectors at follow-up compared to the 6 months prior to the forum. Carefully constructed professional forums improved cross-silo collaboration in the ABI/CJ sectors. This pilot project illustrates effective use of existing service resources, and highlights training as an important part of a raft of initiatives needed to address the overrepresentation of people with ABI in the CJ system.

Osthole shows the potential to overcome P-glycoprotein‑mediated multidrug resistance in human myelogenous leukemia K562/ADM cells by inhibiting the PI3K/Akt signaling pathway.

PubMed

Wang, Hong; Jia, Xiu-Hong; Chen, Jie-Ru; Wang, Jian-Yong; Li, You-Jie

2016-06-01

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) has been reported to play a pivotal role in tumor chemotherapy failure. Study after study has illustrated that the phosphoinositide 3-kinase (PI3K)/Akt signaling cascade is involved in the MDR phenotype and is correlated with P-gp expression in many human malignancies. In the present study, osthole, an O-methylated coumarin, exhibited potent reversal capability of MDR in myelogenous leukemia K562/ADM cells. Simultaneously, the uptake and efflux of Rhodamine-123 (Rh-123) and the accumulation of doxorubicin assays combined with flow cytometric analysis suggested that osthole could increase intracellular drug accumulation. Furthermore, osthole decreased the expression of multidrug resistance gene 1 (MDR1) at both the mRNA and protein levels. Further experiments elucidated that osthole could suppress P-gp expression by inhibiting the PI3K/Akt signaling pathway which might be the main mechanism accounting for the reversal potential of osthole in the MDR in K562/ADM cells. In conclusion, osthole combats MDR and could be a promising candidate for the development of novel MDR reversal modulators.

Quality Management and Building Government Information Services.

ERIC Educational Resources Information Center

Farrell, Maggie

1998-01-01

Discusses serving library-patron needs in terms of customer service and quality control. Highlights include tools for measuring the quality of service (e.g., the SERVQUAL survey), advisory boards or focus groups, library "service statements," changing patron needs, new information formats, and justifying depository library services. (JAK)

Supporting UK adaptation: building services for the next set of UK climate projections

NASA Astrophysics Data System (ADS)

Fung, Fai; Lowe, Jason

2016-04-01

As part of the Climate Change Act 2008, the UK Government sets out a national adaptation programme to address the risks and opportunities identified in a national climate change risk assessment (CCRA) every five years. The last risk assessment in 2012 was based on the probabilistic projections for the UK published in 2009 (UKCP09). The second risk assessment will also use information from UKCP09 alongside other evidence on climate projections. However, developments in the science of climate projeciton, and evolving user needs (based partly on what has been learnt about the diverse user requirements of the UK adaptation community from the seven years of delivering and managing UKCP09 products, market research and the peer-reviewed literature) suggest now is an appropriate time to update the projections and how they are delivered. A new set of UK climate projections are now being produced to upgrade UKCP09 to reflect the latest developments in climate science, the first phase of which will be delivered in 2018 to support the third CCRA. A major component of the work is the building of a tailored service to support users of the new projections during their development and to involve users in key decisions so that the projections are of most use. We will set out the plan for the new climate projections that seek to address the evolving user need. We will also present a framework which aims to (i) facilitate the dialogue between users, boundary organisations and producers, reflecting their different decision-making roles (ii) produce scientifically robust, user-relevant climate information (iii) provide the building blocks for developing further climate services to support adaptation activities in the UK.

29 CFR 779.335 - Sales of building materials for residential or farm building construction.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Sales of building materials for residential or farm... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of building... the category of sales for resale “the sale of goods to be used in residential or farm building...

29 CFR 779.335 - Sales of building materials for residential or farm building construction.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Sales of building materials for residential or farm... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of building... the category of sales for resale “the sale of goods to be used in residential or farm building...

29 CFR 779.335 - Sales of building materials for residential or farm building construction.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Sales of building materials for residential or farm... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of building... the category of sales for resale “the sale of goods to be used in residential or farm building...

29 CFR 779.335 - Sales of building materials for residential or farm building construction.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Sales of building materials for residential or farm... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of building... the category of sales for resale “the sale of goods to be used in residential or farm building...

29 CFR 779.335 - Sales of building materials for residential or farm building construction.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Sales of building materials for residential or farm... for Certain Retail or Service Establishments Sales Not Made for Resale § 779.335 Sales of building... the category of sales for resale “the sale of goods to be used in residential or farm building...

Verification for robustness to laser-induced damage for the Aladin instrument on the ADM-Aeolus satellite

NASA Astrophysics Data System (ADS)

Wernham, Denny; Ciapponi, Alessandra; Riede, Wolfgang; Allenspacher, Paul; Era, Fabio; D'Ottavi, Alessandro; Thibault, Dominique

2016-12-01

The Aladin instrument will fly on the European Space Agency's ADM Aeolus satellite. The instrument is a Doppler wind LIDAR, primarily designed to measure global wind profiles to improve the accuracy of numerical weather prediction models. At the heart of the instrument is a frequency stabilized 355nm laser which will emit approximately 100mJ of energy in the form of 20ns pulses with a fluence around 1Jcm-2. The pulse repetition frequency is 50Hz meaning that Aladin will eventually have to accumulate 5Gshots over its 3 years planned lifetime in orbit. Due to anomalies that have occurred on previous spaceborne lasers, as well as a number of failures that we have observed in previous tests, an extensive development and verification campaign was undertaken in order to ensure that the Aladin instrument is robust enough to survive the mission. In this paper, we shall report the logic and the results of this verification campaign.

Mathematical modeling of the heat transfer for determining the depth of thawing basin buildings with long service life

NASA Astrophysics Data System (ADS)

Sirditov, Ivan; Stepanov, Sergei

2017-11-01

In this paper, a numerical study of the problem of determining a thawing basin in the permafrost soil for buildings with a long service life is carried out using two methods, with the formulas of set of rules 25.13330.2012 "Soil bases and foundations on permafrost soils" and using a mathematical model.

An interactive integrative approach to translating knowledge and building a "learning organization" in health services management.

PubMed Central

Chunharas, Somsak

2006-01-01

This paper proposes a basic approach to ensuring that knowledge from research studies is translated for use in health services management with a view towards building a "learning organization". (A learning organization is one in which the environment is structured in such a way as to facilitate learning as well as the sharing of knowledge among members or employees.) This paper highlights various dimensions that determine the complexity of knowledge translation, using the problem-solving cycle as the backbone for gaining a better understanding of how different types of knowledge interact in health services management. It is essential to use an integrated and interactive approach to ensure that knowledge from research is translated in a way that allows a learning organization to be built and that knowledge is not used merely to influence a single decision in isolation from the overall services and management of an organization. PMID:16917653

Building Languages

MedlinePlus

... Support Services Technology and Audiology Medical and Surgical Solutions Putting it all Together Building Language American Sign Language (ASL) Conceptually Accurate Signed English (CASE) Cued Speech Finger Spelling Listening/Auditory Training ...

Technicians for Intelligent Buildings. Final Report.

ERIC Educational Resources Information Center

Prescott, Carolyn; Thomson, Ron

"Intelligent building" is a term that has been coined in recent years to describe buildings in which computer technology is intensely applied in two areas of building operations: control systems and shared tenant services. This two-part study provides an overview of the intelligent building industry and reports on issues related to the…

NASA Lewis Nickel Alloy being Poured in the Technical Service Building

NASA Image and Video Library

1966-04-21

A nickel alloy developed at the National Aeronautics and Space Administration (NASA) Lewis Research Center being poured in a shop inside the Technical Services Building. Materials technology is an important element in the successful development of both advanced airbreathing and rocket propulsion systems. An array of dependable materials is needed to build different types of engines for operation in diverse environments. NASA Lewis began investigating the characteristics of different materials shortly after World War II. In 1949 the materials research group was expanded into its own division. The Lewis researchers studied and tested materials in environments that simulated the environment in which they would operate. Lewis created two programs in the early 1960s to create materials for new airbreathing engines. One concentrated on high-temperature alloys and the other on cooling turbine blades. William Klopp, Peter Raffo, Lester Rubenstein, and Walter Witzke developed Tungsten RHC, the highest strength metal at temperatures over 3500⁰ F. The men received an IR-100 Award for their efforts. Similarly a cobalt-tungsten alloy was developed by the Fatigue and Alloys Research Branch. The result was a combination of high temperature strength and magnetic properties that were applicable for generator rotor application. John Freche invented and patented a nickel alloy while searching for high temperature metals for aerospace use. NASA agreed to a three-year deal which granted Union Carbide exclusive use of the new alloy before it became public property.

7 CFR 1726.150 - Headquarters buildings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Headquarters buildings. 1726.150 Section 1726.150 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Buildings § 1726.150 Headquarters buildings...

K-8 Pre-Service Teachers' Algebraic Thinking: Exploring the Habit of Mind "Building Rules to Represent Functions"

ERIC Educational Resources Information Center

Magiera, Marta T.; van den Kieboom, Leigh A.; Moyer, John C.

2017-01-01

In this study, we examined the ability of grades 1-8 pre-service teachers (PSTs) to engage in thinking about patterns, relationships, and functional rules. Using the algebraic habit of mind Building Rules to Represent Functions as a framework, we examined whether and how well our PSTs (n = 18) used seven features of this habit of mind: organize…

Quality site seasonal report: Army Air Force Exchange Service Headquarters Building, SFBP 1343, August 1984 through May 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pollock, E.O. Jr.

1987-10-15

The active solar Domestic Hot Water (DHW) system at the HQ Army-Air Force Exchange Service (AAFES) Building was designed and constructed as part of the Solar in Federal Buildings Programs (SFBP). This retrofitted system is one of eight of the systems in the SFBP selected for quality monitoring. The purpose of this monitoring effort is to document the performance of quality state-of-the-art solar systems in large federal building applications. The six-story HQ AAFES Building houses a cafeteria, officer's mess and club and office space for 2400 employees. The siphon-return drainback system uses 1147 ft/sup 2/ of Aircraftsman flat-plate collectors tomore » collect solar energy which is used to preheat domestic hot water. Solar energy is stored in a 1329-gallon tank and transferred to the hot water load through a heat exchanger located in the 356-gallon DHW preheat tank. Auxiliary energy is supplied by two gas fired boilers which boost the temperature to 130/sup 0/F before it is distributed to the load. Highlights of the performance of the HQ AAFES Building solar system during the monitoring period from August 1984 through May 1985 are presented in this report.« less

7 CFR Exhibit E to Subpart A of... - Voluntary National Model Building Codes

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Voluntary National Model Building Codes E Exhibit E... HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY... National Model Building Codes The following documents address the health and safety aspects of buildings...

Providing Personalized Energy Management and Awareness Services for Energy Efficiency in Smart Buildings.

PubMed

Fotopoulou, Eleni; Zafeiropoulos, Anastasios; Terroso-Sáenz, Fernando; Şimşek, Umutcan; González-Vidal, Aurora; Tsiolis, George; Gouvas, Panagiotis; Liapis, Paris; Fensel, Anna; Skarmeta, Antonio

2017-09-07

Considering that the largest part of end-use energy consumption worldwide is associated with the buildings sector, there is an inherent need for the conceptualization, specification, implementation, and instantiation of novel solutions in smart buildings, able to achieve significant reductions in energy consumption through the adoption of energy efficient techniques and the active engagement of the occupants. Towards the design of such solutions, the identification of the main energy consuming factors, trends, and patterns, along with the appropriate modeling and understanding of the occupants' behavior and the potential for the adoption of environmentally-friendly lifestyle changes have to be realized. In the current article, an innovative energy-aware information technology (IT) ecosystem is presented, aiming to support the design and development of novel personalized energy management and awareness services that can lead to occupants' behavioral change towards actions that can have a positive impact on energy efficiency. Novel information and communication technologies (ICT) are exploited towards this direction, related mainly to the evolution of the Internet of Things (IoT), data modeling, management and fusion, big data analytics, and personalized recommendation mechanisms. The combination of such technologies has resulted in an open and extensible architectural approach able to exploit in a homogeneous, efficient and scalable way the vast amount of energy, environmental, and behavioral data collected in energy efficiency campaigns and lead to the design of energy management and awareness services targeted to the occupants' lifestyles. The overall layered architectural approach is detailed, including design and instantiation aspects based on the selection of set of available technologies and tools. Initial results from the usage of the proposed energy aware IT ecosystem in a pilot site at the University of Murcia are presented along with a set of identified

Providing Personalized Energy Management and Awareness Services for Energy Efficiency in Smart Buildings

PubMed Central

Fotopoulou, Eleni; Tsiolis, George; Gouvas, Panagiotis; Liapis, Paris; Fensel, Anna; Skarmeta, Antonio

2017-01-01

Considering that the largest part of end-use energy consumption worldwide is associated with the buildings sector, there is an inherent need for the conceptualization, specification, implementation, and instantiation of novel solutions in smart buildings, able to achieve significant reductions in energy consumption through the adoption of energy efficient techniques and the active engagement of the occupants. Towards the design of such solutions, the identification of the main energy consuming factors, trends, and patterns, along with the appropriate modeling and understanding of the occupants’ behavior and the potential for the adoption of environmentally-friendly lifestyle changes have to be realized. In the current article, an innovative energy-aware information technology (IT) ecosystem is presented, aiming to support the design and development of novel personalized energy management and awareness services that can lead to occupants’ behavioral change towards actions that can have a positive impact on energy efficiency. Novel information and communication technologies (ICT) are exploited towards this direction, related mainly to the evolution of the Internet of Things (IoT), data modeling, management and fusion, big data analytics, and personalized recommendation mechanisms. The combination of such technologies has resulted in an open and extensible architectural approach able to exploit in a homogeneous, efficient and scalable way the vast amount of energy, environmental, and behavioral data collected in energy efficiency campaigns and lead to the design of energy management and awareness services targeted to the occupants’ lifestyles. The overall layered architectural approach is detailed, including design and instantiation aspects based on the selection of set of available technologies and tools. Initial results from the usage of the proposed energy aware IT ecosystem in a pilot site at the University of Murcia are presented along with a set of

Building capacity in social service agencies to employ peer providers.

PubMed

Gates, Lauren B; Mandiberg, James M; Akabas, Sheila H

2010-01-01

While there is evidence that peer providers are valuable to service delivery teams, the agencies where they work face difficulties in fulfilling the potential of including peers on staff effectively. The purpose of this article is to report findings of a pilot test of a workplace strategy that promoted inclusion of peer providers at social service agencies by building organizational capacity to support people with mental health conditions in peer provider roles. The strategy included training, goal setting and ongoing consultation. Seventy-one peer, non-peer and supervisory staff participated from 6 agencies over a one year period. Goal attainment scaling and data from in-depth interviews about perceptions of differences in the ways in which staff are supported, administered prior to and after the consultation period, were used to assess strategy impact. Most frequently staff set goals to respond to role conflict or a lack of support. Staff that met or exceeded their goals utilized the formal structure of consultation to improve communication among themselves, had leadership that sanctioned changes and felt that their participation was of value to the organization and contributed to their individual development. Strategy participation promoted inclusion by initiating changes to policies and practices that devalued the peer provider role, increased skill sets, and formalized lines of communication for sharing information and understanding related to peer providers. Findings demonstrate that a strategy of training, goal setting and consultation can positively affect perceptions of inclusion, and promote implementation of practices associated with inclusive workplaces.

Measurements of the Received Signal Level and Service Coverage Area at the IEEE 802.11 Access Point in the Building

NASA Astrophysics Data System (ADS)

Gunantara, N.; Sudiarta, P. K.; Prasetya, AAN A. I.; Dharma, A.; Gde Antara, I. N.

2018-04-01

Access point (AP) is part of a Wireless Local Access Network (WLAN) with its communications using WiFi. AP is used to transmit and receive data to users/clients. The ability of AP to serve users/clients depends on many factors. Moreover, if AP is applied in conditions inside the building. In this study, AP is installed at two points inside the building and then measured in the form of the received signal level (RSL) and service coverage area. One AP measured its performance by 26 measurement points and the other AP measured its performance by 20 measurement points. When AP has measured its performance then another AP position is switched off. Based on the measurement result, the received signal level value is the highest value is about -47 dBm at a distance of 3.2 m, while the lowest is about -79 dBm at a 9.21 m because it is on barrier 2 walls. While based on service coverage area, the area which is far away from the AP then the quality of service becomes bad because the transmitted signal is weakening caused by the distance and the loss of the wall.

The EPOS Implementation Phase: building thematic and integrated services for solid Earth sciences

NASA Astrophysics Data System (ADS)

Cocco, Massimo; Epos Consortium, the

2015-04-01

The European Plate Observing System (EPOS) has a scientific vision and approach aimed at creating a pan-European infrastructure for Earth sciences to support a safe and sustainable society. To follow this vision, the EPOS mission is integrating a suite of diverse and advanced Research Infrastructures (RIs) in Europe relying on new e-science opportunities to monitor and understand the dynamic and complex Earth system. To this goal, the EPOS Preparatory Phase has designed a long-term plan to facilitate integrated use of data and products as well as access to facilities from mainly distributed existing and new research infrastructures for solid Earth Science. EPOS will enable innovative multidisciplinary research for a better understanding of the Earth's physical processes that control earthquakes, volcanic eruptions, ground instability and tsunami as well as the processes driving tectonics and Earth surface dynamics. Through integration of data, models and facilities EPOS will allow the Earth Science community to make a step change in developing new concepts and tools for key answers to scientific and socio-economic questions concerning geo-hazards and geo-resources as well as Earth sciences applications to the environment and to human welfare. Since its conception EPOS has been built as "a single, Pan-European, sustainable and distributed infrastructure". EPOS is, indeed, the sole infrastructure for solid Earth Science in ESFRI and its pan-European dimension is demonstrated by the participation of 23 countries in its preparatory phase. EPOS is presently moving into its implementation phase further extending its pan-European dimension. The EPOS Implementation Phase project (EPOS IP) builds on the achievements of the successful EPOS preparatory phase project. The EPOS IP objectives are synergetic and coherent with the establishment of the new legal subject (the EPOS-ERIC in Italy). EPOS coordinates the existing and new solid Earth RIs within Europe and builds the

CEMS: Building a Cloud-Based Infrastructure to Support Climate and Environmental Data Services

NASA Astrophysics Data System (ADS)

Kershaw, P. J.; Curtis, M.; Pechorro, E.

2012-04-01

CEMS, the facility for Climate and Environmental Monitoring from Space, is a new joint collaboration between academia and industry to bring together their collective expertise to support research into climate change and provide a catalyst for growth in related Earth Observation (EO) technologies and services in the commercial sector. A recent major investment by the UK Space Agency has made possible the development of a dedicated facility at ISIC, the International Space Innovation Centre at Harwell in the UK. CEMS has a number of key elements: the provision of access to large-volume EO and climate datasets co-located with high performance computing facilities; a flexible infrastructure to support the needs of research projects in the academic community and new business opportunities for commercial companies. Expertise and tools for scientific data quality and integrity are another essential component, giving users confidence and transparency in its data, services and products. Central to the development of this infrastructure is the utilisation of cloud-based technology: multi-tenancy and the dynamic provision of resources are key characteristics to exploit in order to support the range of organisations using the facilities and the varied use cases. The hosting of processing services and applications next to the data within the CEMS facility is another important capability. With the expected exponential increase in data volumes within the climate science and EO domains it is becoming increasingly impracticable for organisations to retrieve this data over networks and provide the necessary storage. Consider for example, the factor of o20 increase in data volumes expected for the ESA Sentinel missions over the equivalent Envisat instruments. We explore the options for the provision of a hybrid community/private cloud looking at offerings from the commercial sector and developments in the Open Source community. Building on this virtualisation layer, a further core

Strategic service-line planning. Building competitive advantage.

PubMed

Greenspan, Elizabeth; Krentz, Susanna E; O'Neill, Molly K

2003-12-01

Service-line planning requires a healthcare organization to develop a business plan for each of its service lines. Successful service-line planning requires top leadership support, a willingness to allocate resources, the development of support mechanisms, the active support and involvement of physicians, and management commitment and accountability during implementation.

10 CFR 434.518 - Service water heating.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Service water heating. 434.518 Section 434.518 Energy... RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1The service water loads for Prototype and Reference Buildings are defined in terms of Btu/h per person in...

10 CFR 434.518 - Service water heating.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Service water heating. 434.518 Section 434.518 Energy... RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1 The service water loads for Prototype and Reference Buildings are defined in terms of Btu/h per person in...

10 CFR 434.518 - Service water heating.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Service water heating. 434.518 Section 434.518 Energy... RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1The service water loads for Prototype and Reference Buildings are defined in terms of Btu/h per person in...

The effects of health sector market factors and vulnerable group membership on access to alcohol, drug, and mental health care.

PubMed

Stockdale, Susan E; Tang, Lingqi; Zhang, Lily; Belin, Thomas R; Wells, Kenneth B

2007-06-01

This study adapts Andersen's Behavioral Model to determine if health sector market conditions affect vulnerable subgroups' use of alcohol, drug, and mental health services (ADM) differently than the general population, focusing specifically on community-level predisposing and enabling characteristics. Wave 2 data (2000-2001) from the Health Care for Communities study, supplemented with cases from wave 1 (1997-1998), were merged with area characteristics taken from Census, Area Resource File (ARF), and other data sources. The study used four-level hierarchical logistic regression to examine access to ADM care from any provider and specialty ADM access. Interactions between community-level predisposing and enabling vulnerability characteristics with individual race/ethnicity, age, income category, and insurance type were explored. Nonwhites, the poor, uninsured, and elderly had lower likelihoods of service use, but interactions between race/ethnicity, income, age and insurance status with community-level vulnerability factors were not statistically significant for any service use. For ADM specialty care, those with Medicare, Medicaid, private fully managed, and private partially managed insurance, the likelihood of utilization was higher in areas with higher HMO penetration. However, for those with other insurance or no insurance plan, the likelihood of utilization was lower in areas with higher HMO penetration. Community-level enabling factors explain part of the effect of disadvantaged status but, with the exception of the effect of HMO penetration on the relationship between insurance and specialty care use, do not modify any of the residual individual-level effects of disadvantage. Interventions targeting both structural and individual levels may be necessary to address the problem of health disparities. More research with longitudinal data is necessary to sort out the causal direction of social context and ADM access outcomes, and whether policy interventions to

23 CFR 710.313 - Design-build projects.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Design-build projects. 710.313 Section 710.313 Highways... REAL ESTATE Project Development § 710.313 Design-build projects. (a) In the case of a design-build...-way acquisition and clearance services may be incorporated into the design-build contract if allowed...

23 CFR 710.313 - Design-build projects.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Design-build projects. 710.313 Section 710.313 Highways... REAL ESTATE Project Development § 710.313 Design-build projects. (a) In the case of a design-build...-way acquisition and clearance services may be incorporated into the design-build contract if allowed...

23 CFR 710.313 - Design-build projects.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Design-build projects. 710.313 Section 710.313 Highways... REAL ESTATE Project Development § 710.313 Design-build projects. (a) In the case of a design-build...-way acquisition and clearance services may be incorporated into the design-build contract if allowed...

Solar Mirror Fabrication in the Technical Services Building

NASA Image and Video Library

1966-02-21

Daniel Bernatowicz, Chief of the Advanced Power Systems Branch at the National Aeronautics and Space Administration (NASA) Lewis Research Center, examines a 20-foot section of a solar mirror being fabricated in the Jig Bore Room of the Technical Services Building. NASA Lewis was conducting a wide-ranging effort to explore methods of generating electrical power for spacecraft. One method employed a large parabolic mirror to concentrate the sun’s energy. The mirror had to remain rigid and withstand micrometeoroids, but remain light and compact enough to be easily launched. In 1963 Bernatowicz and his researchers undertook a program to design a solar mirror to work with the Brayton cycle system on a space station. The mirror in this photograph was prepared for a conference on Advanced Technology in Space Power Systems held at Lewis in late August 1966. Lewis experts discussed advances with batteries, fuel cells, isotope and thermoelectric generators, and the SNAP-8 space power system. Lewis was developing several types of solar mirrors to work with a Brayton cycle electric generating system. The mirror’s 12 sections were shaped using a unique forming process developed at Lewis, coated with an epoxy, and plated with aluminum. The mirror concentrated the Sun's rays on a heat storage receiver containing lithium fluoride. This material was heated to produce power in a turbogenerator system, while additional heat was stored for use when the unit was in the Earth's shadow.

Typological diversity of tall buildings and complexes in relation to their functional structure

NASA Astrophysics Data System (ADS)

Generalov, Viktor P.; Generalova, Elena M.; Kalinkina, Nadezhda A.; Zhdanova, Irina V.

2018-03-01

The paper focuses on peculiarities of tall buildings and complexes, their typology and its formation in relation to their functional structure. The research is based on the analysis of tall buildings and complexes and identifies the following main functional elements of their formation: residential, administrative (office), hotel elements. The paper also considers the following services as «disseminated» in the space-planning structure: shops, medicine, entertainment, kids and sports facilities, etc., their location in the structure of the total bulk of the building and their impact on typological diversity. Research results include suggestions to add such concepts as «single-function tall buildings» and «mixed-use tall buildings and complexes» into the classification of tall buildings. In addition, if a single-function building or complex performs serving functions, it is proposed to add such concepts as «a residential tall building (complex) with provision of services», «an administrative (public) tall building (complex) with provision of services» into the classification of tall buildings. For mixed-use buildings and complexes the following terms are suggested: «a mixed-use tall building with provision of services», «a mixed-use tall complex with provision of services».

Smart Buildings and Demand Response

NASA Astrophysics Data System (ADS)

Kiliccote, Sila; Piette, Mary Ann; Ghatikar, Girish

2011-11-01

Advances in communications and control technology, the strengthening of the Internet, and the growing appreciation of the urgency to reduce demand side energy use are motivating the development of improvements in both energy efficiency and demand response (DR) systems in buildings. This paper provides a framework linking continuous energy management and continuous communications for automated demand response (Auto-DR) in various times scales. We provide a set of concepts for monitoring and controls linked to standards and procedures such as Open Automation Demand Response Communication Standards (OpenADR). Basic building energy science and control issues in this approach begin with key building components, systems, end-uses and whole building energy performance metrics. The paper presents a framework about when energy is used, levels of services by energy using systems, granularity of control, and speed of telemetry. DR, when defined as a discrete event, requires a different set of building service levels than daily operations. We provide examples of lessons from DR case studies and links to energy efficiency.

The First Six Years of Building and Implementing a Return-to-Work Service for Patients with Acquired Brain Injury. The Rapid-Return-to-Work-Cohort-Study.

PubMed

Haveraaen, L; Brouwers, E P M; Sveen, U; Skarpaas, L S; Sagvaag, H; Aas, R W

2017-12-01

Background and objective Despite large activity worldwide in building and implementing new return-to-work (RTW) services, few studies have focused on how such implementation processes develop. The aim of this study was to examine the development in patient and service characteristics the first six years of implementing a RTW service for persons with acquired brain injury (ABI). Methods The study was designed as a cohort study (n=189). Data were collected by questionnaires, filled out by the service providers. The material was divided into, and analyzed with, two implementation phases. Non-parametrical statistical methods and hierarchical regression analyses were applied on the material. Results The number of patients increased significantly, and the patient group became more homogeneous. Both the duration of the service, and the number of consultations and group session days were significantly reduced. Conclusion The patient group became more homogenous, but also significantly larger during the first six years of building the RTW service. At the same time, the duration of the service decreased. This study therefore questions if there is a lack of consensus on the intensity of work rehabilitation for this group.

Energy Savings Modeling and Inspection Guidelines for Commercial Building Federal Tax Deductions for Buildings in 2016 and Later

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deru, Michael; Field-Macumber, Kristin

This document provides guidance for modeling and inspecting energy-efficient property in commercial buildings for certification of the energy and power cost savings related to Section 179D of the Internal Revenue Code (IRC) enacted in Section 1331 of the 2005 Energy Policy Act (EPAct) of 2005, noted in Internal Revenue Service (IRS) Notices 2006-52 (IRS 2006), 2008-40 (IRS 2008) and 2012-26 (IRS 2012), and updated by the Protecting Americans from Tax Hikes (PATH) Act of 2015. Specifically, Section 179D provides federal tax deductions for energy-efficient property related to a commercial building's envelope; interior lighting; heating, ventilating, and air conditioning (HVAC); andmore » service hot water (SHW) systems. This document applies to buildings placed in service on or after January 1, 2016.« less

Confidence-Building Measures in Philippine Security.

DTIC Science & Technology

1998-05-01

service or government agency. STRATEGY RESEARCH PROJECT i CONFIDENCE-BUILDING MEASURES IN PHILIPPINE SECURITY BY LIEUTENANT COLONEL RAMON G...WAR COLLEGE, CARLISLE BARRACKS, PA 17013-5050 rimo*’^»®*raBl USAWC STRATEGY RESEARCH PROJECT CONFIDENCE-BUILDING MEASURES IN PHILIPPINE...Colonel Ramon Santos, Philippine Army TITLE: Confidence-Building Measures in Philippine Security FORMAT: Strategy Research Project DATE: 1

14. A westward view of building #5 in the background, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. A westward view of building #5 in the background, low buildings #22 and #23 in the center and supports for the water tower. The roadway was previously rail service to buildings #3, #5, and #9. The trackage had been mostly covered with fill, representing the transition from rail to truck service. The two enclosed passageways to the left of center carried semi-processed tire chain from building #9, on the left, to buildings #3 and #5. - American Chain & Cable Company, East Princess Street (400 Block), York, York County, PA

47 CFR 54.502 - Eligible services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SERVICE Universal Service Support for Schools and Libraries § 54.502 Eligible services. (a) Supported... comprise a single library branch. Discounts are not available for internal connections in non-instructional buildings of a school or school district, or in administrative buildings of a library, to the extent that a...

Modified ADM1 disintegration/hydrolysis structures for modeling batch thermophilic anaerobic digestion of thermally pretreated waste activated sludge.

PubMed

Ramirez, Ivan; Mottet, Alexis; Carrère, Hélène; Déléris, Stéphane; Vedrenne, Fabien; Steyer, Jean-Philippe

2009-08-01

Anaerobic digestion disintegration and hydrolysis have been traditionally modeled according to first-order kinetics assuming that their rates do not depend on disintegration/hydrolytic biomass concentrations. However, the typical sigmoid-shape increase in time of the disintegration/hydrolysis rates cannot be described with first-order models. For complex substrates, first-order kinetics should thus be modified to account for slowly degradable material. In this study, a slightly modified IWA ADM1 model is presented to simulate thermophilic anaerobic digestion of thermally pretreated waste activated sludge. Contois model is first included for disintegration and hydrolysis steps instead of first-order kinetics and Hill function is then used to model ammonia inhibition of aceticlastic methanogens instead of a non-competitive function. One batch experimental data set of anaerobic degradation of a raw waste activated sludge is used to calibrate the proposed model and three additional data sets from similar sludge thermally pretreated at three different temperatures are used to validate the parameters values.

Building a Secure and Feature-rich Mobile Mapping Service App Using HTML5: Challenges and Best Practices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karthik, Rajasekar; Patlolla, Dilip Reddy; Sorokine, Alexandre

Managing a wide variety of mobile devices across multiple mobile operating systems is a security challenge for any organization [1, 2]. With the wide adoption of mobile devices to access work-related apps, there is an increase in third-party apps that might either misuse or improperly handle user s personal or sensitive data [3]. HTML5 has been receiving wide attention for developing cross-platform mobile apps. According to International Data Corporation (IDC), by 2015, 80% of all mobile apps will be based in part or wholly upon HTML5 [4]. Though HTML5 provides a rich set of features for building an app, itmore » is a challenge for organizations to deploy and manage HTML5 apps on wide variety of devices while keeping security policies intact. In this paper, we will describe an upcoming secure mobile environment for HTML5 apps, called Sencha Space that addresses these issues and discuss how it will be used to design and build a secure and cross-platform mobile mapping service app. We will also describe how HTML5 and a new set of related technologies such as Geolocation API, WebGL, Open Layers 3, and Local Storage, can be used to provide a high end and high performance experience for users of the mapping service app.« less

300 Area Building Retention Evaluation Mitigation Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

D. J. McBride

2007-07-03

Evaluate the long-term retention of several facilities associated with the PNNL Capability Replacement Laboratory and other Hanfor mission needs. WCH prepared a mitigation plan for three scenarios with different release dates for specific buildings. The evaluations present a proposed plan for providing utility services to retained facilities in support of a long-term (+20 year) lifespan in addition to temporary services to buildings with specified delayed release dates.

Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

PubMed Central

2010-01-01

As part of our effort to increase survival of drug candidates and to move our medicinal chemistry design to higher probability space for success in the Neuroscience therapeutic area, we embarked on a detailed study of the property space for a collection of central nervous system (CNS) molecules. We carried out a thorough analysis of properties for 119 marketed CNS drugs and a set of 108 Pfizer CNS candidates. In particular, we focused on understanding the relationships between physicochemical properties, in vitro ADME (absorption, distribution, metabolism, and elimination) attributes, primary pharmacology binding efficiencies, and in vitro safety data for these two sets of compounds. This scholarship provides guidance for the design of CNS molecules in a property space with increased probability of success and may lead to the identification of druglike candidates with favorable safety profiles that can successfully test hypotheses in the clinic. PMID:22778836

Building Strengths in the Neighborhood

ERIC Educational Resources Information Center

Quigley, Richard

2005-01-01

This article features Woodland Hills's Neighborhood Youth Services. The Neighborhood Youth Services (NYS) program is a community-based program created by Woodland Hills, a residential program for troubled adolescents in Duluth, Minnesota. Principles for building respectful adult and peer relationships developed in the treatment environment were…

Developing Verification Systems for Building Information Models of Heritage Buildings with Heterogeneous Datasets

NASA Astrophysics Data System (ADS)

Chow, L.; Fai, S.

2017-08-01

The digitization and abstraction of existing buildings into building information models requires the translation of heterogeneous datasets that may include CAD, technical reports, historic texts, archival drawings, terrestrial laser scanning, and photogrammetry into model elements. In this paper, we discuss a project undertaken by the Carleton Immersive Media Studio (CIMS) that explored the synthesis of heterogeneous datasets for the development of a building information model (BIM) for one of Canada's most significant heritage assets - the Centre Block of the Parliament Hill National Historic Site. The scope of the project included the development of an as-found model of the century-old, six-story building in anticipation of specific model uses for an extensive rehabilitation program. The as-found Centre Block model was developed in Revit using primarily point cloud data from terrestrial laser scanning. The data was captured by CIMS in partnership with Heritage Conservation Services (HCS), Public Services and Procurement Canada (PSPC), using a Leica C10 and P40 (exterior and large interior spaces) and a Faro Focus (small to mid-sized interior spaces). Secondary sources such as archival drawings, photographs, and technical reports were referenced in cases where point cloud data was not available. As a result of working with heterogeneous data sets, a verification system was introduced in order to communicate to model users/viewers the source of information for each building element within the model.

Systematic Consensus Building on Disaster Mental Health Services After the Great East Japan Earthquake by Phase.

PubMed

Fukasawa, Maiko; Suzuki, Yuriko; Nakajima, Satomi; Asano, Keiko; Narisawa, Tomomi; Kim, Yoshiharu

2015-08-01

We intended to build consensus on appropriate disaster mental health services among professionals working in the area affected by the Great East Japan Earthquake. We focused on the first 3 months after the disaster, divided into 3 phases: immediate aftermath, acute phase, and midphase. We adopted the Delphi process and asked our survey participants (n=115) to rate the appropriateness of specific mental health services in each phase and comment on them. We repeated this process 3 times, giving participants feedback on the results of the previous round. Through this process, we determined the criterion for positive consensus for each item as having the agreement of more than 80% of the participants. We found that the importance of acute psychiatric care and prescribing regular medication for psychiatric patients gained positive consensus in the immediate aftermath and acute phase. Counseling and psychoeducation after traumatic events or provision of information gained consensus in the acute phase and midphase, and screening of mental distress gained consensus in the midphase. Higher priority was given to continuous psychiatric services in the immediate aftermath and mental health activities in later phases.

47 CFR 22.383 - In-building radiation systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false In-building radiation systems. 22.383 Section... MOBILE SERVICES Operational and Technical Requirements Technical Requirements § 22.383 In-building radiation systems. Licensees may install and operate in-building radiation systems without applying for...

Energy audit role in building planning

NASA Astrophysics Data System (ADS)

Sipahutar, Riman; Bizzy, Irwin

2017-11-01

An energy audit is one way to overcome the excessive use of energy in buildings. The increasing growth of population, economy, and industry will have an impact on energy demand and the formation of greenhouse gas emissions. Indonesian National Standard (SNI) concerning the building has not been implemented optimally due to the socialization process by a government not yet been conducted. An energy audit of buildings has been carried out at offices and public services. Most electrical energy in buildings used for air refresher equipment or air conditioning. Calculation of OTTV has demonstrated the importance of performing since the beginning of the planning of a building to get energy-efficient buildings.

HOT CELL BUILDING, TRA632. EAST END OF BUILDING. CAMERA FACING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HOT CELL BUILDING, TRA-632. EAST END OF BUILDING. CAMERA FACING WEST. TRUCK ENCLOSURE (1986) TO THE LEFT, SMALL ADDITION IN ITS SHADOW IS ENCLOSURE OVER METAL PORT INTO HOT CELL NO. 1 (THE OLDEST HOT CELL). NOTE PERSONNEL LADDER AND PLATFORM AT LOFT LEVEL USED WHEN SERVICING AIR FILTERS AND VENTS OF CELL NO. 1. INL NEGATIVE NO. HD46-32-4. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

EPRI and Schneider Electric Demonstrate Distributed Resource Communications

Science.gov Websites

Electric Power Research Institute (EPRI) is designing, building, and testing a flexible, open-source Schneider Electric ADMS, open software platforms, an open-platform home energy management system

Cornerstones: Building Rural America through Service Learning.

ERIC Educational Resources Information Center

Pace, Jerry

Students in a poor, rural county in South Carolina worked with their community to build a new volunteer fire station, enabling many residents to get fire insurance. The project enabled students to see the relevance of education and to be seen as solutions to problems rather than as problems, generated enthusiasm among students toward the community…

Building a science of partnership-focused research: forging and sustaining partnerships to support child mental health prevention and services research.

PubMed

Bradshaw, Catherine P; Haynes, Katherine Taylor

2012-07-01

Building on growing interest in translational research, this paper provides an overview of a special issue of Administration and Policy in Mental Health and Mental Health Service Research, which is focused on the process of forging and sustaining partnerships to support child mental health prevention and services research. We propose that partnership-focused research is a subdiscipline of translational research which requires additional research to better refine the theoretical framework and the core principles that will guide future research and training efforts. We summarize some of the major themes across the eight original articles and three commentaries included in the special issue. By advancing the science of partnership-focused research we will be able to bridge the gap between child mental health prevention and services research and practice.

HIV-positive mothers in Viet Nam: using their status to build support groups and access essential services.

PubMed

Oosterhoff, Pauline; Anh, Nguyen Thu; Yen, Pham Ngoc; Wright, Pamela; Hardon, Anita

2008-11-01

Various support and self-help groups for people living with HIV and their families have developed in Viet Nam in recent years. This paper reports on a case study of Sunflowers, the first support group for HIV positive mothers in Hanoi, begun in 2004, and a sister group begun in 2005 in Thai Nguyen province. From April 2004 to early 2007, we carried out semi-structured interviews with 275 health care workers and 153 HIV-positive women and members of their families, as well as participant observation of group meetings and activities. Sunflowers have successfully organised themselves to access vital social, medical and economic support and services for themselves, their children and partners. They gained self-confidence, and learned to communicate with their peers and voice their needs to service providers. Based on personal development plans, they have accessed other state services, such as loans, job counselling and legal advice. They have also gained access to school and treatment for their children, who had previously been excluded. Although the women were vulnerable to HIV as wives and mothers, motherhood also provided them with social status and an identity they used to help build organisations and develop strategies to access the essential services that they and their families need.

Europe sees mixed results from public-private partnerships for building and managing health care facilities and services.

PubMed

Barlow, James; Roehrich, Jens; Wright, Steve

2013-01-01

Prompted in part by constrained national budgets, European governments are increasingly partnering with the private sector to underwrite the costs of constructing and operating public hospitals and other health care facilities and delivering services. Through such public-private partnerships, governments hope to avoid up-front capital expenditure and to harness private-sector efficiencies, while private-sector partners aim for a return on investment. Our research indicates that to date, experience with these partnerships has been mixed. Early models of these partnerships-for example, in which a private firm builds a hospital and carries out building maintenance, which we term an "accommodation-only" model-arguably have not met expectations for achieving greater efficiencies at lower costs. Newer models described in this article offer greater opportunities for efficiency gains but are administratively harder to set up and manage. Given the shortages in public capital for new infrastructure, it seems likely that the attractiveness of these partnerships to European governments will grow.

All-dielectric metamaterial frequency selective surface

NASA Astrophysics Data System (ADS)

Wang, Jun; Qu, Shaobo; Li, Liyang; Wang, Jiafu; Feng, Mingde; Ma, Hua; Du, Hongliang; Xu, Zhuo

Frequency selective surface (FSS) has been extensively studied due to its potential applications in radomes, antenna reflectors, high-impedance surfaces and absorbers. Recently, a new principle of designing FSS has been proposed and mainly studied in two levels. In the level of materials, dielectric materials instead of metallic patterns are capable of achieving more functional performance in FSS design. Moreover, FSSs made of dielectric materials can be used in different extreme environments, depending on their electrical, thermal or mechanical properties. In the level of design principle, the theory of metamaterial can be used to design FSS in a convenient and concise way. In this review paper, we provide a brief summary about the recent progress in all-dielectric metamaterial frequency selective surface (ADM-FSS). The basic principle of designing ADM-FSS is summarized. As significant tools, Mie theory and dielectric resonator (DR) theory are given which illustrate clearly how they are used in the FSS design. Then, several design cases including dielectric particle-based ADM-FSS and dielectric network-based ADM-FSS are introduced and reviewed. After a discussion of these two types of ADM-FSSs, we reviewed the existing fabrication techniques that are used in building the experiment samples. Finally, issues and challenges regarding the rapid fabrication techniques and further development aspects are discussed.

The Mind-Body Building Equation.

ERIC Educational Resources Information Center

Dryfoos, Joy

2000-01-01

Full-service community schools combine three concepts--mind, body, and building--into an integrated approach placing quality education and comprehensive support services at one site. The DeWitt Wallace-Reader's Digest Fund is helping schools and communities replicate 4 such programs at 60 sites in 20 U.S. cities. (MLH)

Sault Tribe Building Efficiency Energy Audits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holt, Jeffrey W.

2013-09-26

The Sault Ste. Marie Tribe of Chippewa Indians is working to reduce energy consumption and expense in Tribally-owned governmental buildings. The Sault Ste. Marie Tribe of Chippewa Indians will conduct energy audits of nine Tribally-owned governmental buildings in three counties in the Upper Peninsula of Michigan to provide a basis for evaluating and selecting the technical and economic viability of energy efficiency improvement options. The Sault Ste. Marie Tribe of Chippewa Indians will follow established Tribal procurement policies and procedures to secure the services of a qualified provider to conduct energy audits of nine designated buildings. The contracted provider willmore » be required to provide a progress schedule to the Tribe prior to commencing the project and submit an updated schedule with their monthly billings. Findings and analysis reports will be required for buildings as completed, and a complete Energy Audit Summary Report will be required to be submitted with the provider?s final billing. Conducting energy audits of the nine governmental buildings will disclose building inefficiencies to prioritize and address, resulting in reduced energy consumption and expense. These savings will allow Tribal resources to be reallocated to direct services, which will benefit Tribal members and families.« less

BUILDING 122 CONTAINS THREE GENERAL AREAS: OFFICE AREAS, INTERNAL DOSIMETRY, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BUILDING 122 CONTAINS THREE GENERAL AREAS: OFFICE AREAS, INTERNAL DOSIMETRY, AND MEDICAL/HEALTH. BUILDING 122 SHARES A COMMON WALL WITH BUILDING 121, THE PLANT SECURITY BUILDING. THE TWO-STORY BUILDING IN THE BACKGROUND IS BUILDING 111. (9/26/52) - Rocky Flats Plant, Emergency Medical Services Facility, Southwest corner of Central & Third Avenues, Golden, Jefferson County, CO

49 CFR 192.375 - Service lines: Plastic.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the plastic...

49 CFR 192.375 - Service lines: Plastic.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the plastic...

49 CFR 192.375 - Service lines: Plastic.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the plastic...

49 CFR 192.375 - Service lines: Plastic.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the plastic...

49 CFR 192.375 - Service lines: Plastic.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the plastic...

Building Standards and Codes for Energy Conservation

ERIC Educational Resources Information Center

Gross, James G.; Pierlert, James H.

1977-01-01

Current activity intended to lead to energy conservation measures in building codes and standards is reviewed by members of the Office of Building Standards and Codes Services of the National Bureau of Standards. For journal availability see HE 508 931. (LBH)

Field Demonstration of Active Desiccant Modules Designed to Integrate with Standard Unitary Rooftop Package Equipment - Final Report: Phase 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, J

2004-03-15

This report summarizes the investigation of two active desiccant module (ADM) pilot site installations initiated in 2001. Both pilot installations were retrofits at existing facilities served by conventional heating, ventilating, and air-conditioning (HVAC) systems that had encountered frequent humidity control, indoor air quality (IAQ), and other operational problems. Each installation involved combining a SEMCO, Inc., ADM (as described in Fischer and Sand 2002) with a standard packaged rooftop unit built by the Trane Company. A direct digital control (DDC) system integral to the ADM performed the dual function of controlling the ADM/rooftop combination and facilitating data collection, trending, and remotemore » performance monitoring. The first installation involved providing preconditioned outdoor air to replace air exhausted from the large kitchen hood and bathrooms of a Hooters restaurant located in Rome, Georgia. This facility had previously added an additional rooftop unit in an attempt to achieve occupant comfort without success. The second involved conditioning the outdoor air delivered to each room of a wing of the Mountain Creek Inn at the Callaway Gardens resort. This hotel, designed in the ''motor lodge'' format with each room opening to the outdoors, is located in southwest Georgia. Controlling the space humidity always presented a serious challenge. Uncomfortable conditions and musty odors had caused many guests to request to move to other areas within the resort. This is the first field demonstration performed by Oak Ridge National Laboratory where significant energy savings, operating cost savings, and dramatically improved indoor environmental conditions can all be claimed as the results of a retrofit desiccant equipment field installation. The ADM/rooftop combination installed at the restaurant resulted in a reduction of about 34% in the electricity used by the building's air-conditioning system. This represents a reduction of approximately 15

Defense.gov Special Report: Travels with Mullen

Science.gov Websites

Cites Importance of Relationship WASHINGTON, July 11, 2011 - Navy Adm. Mike Mullen, chairman of the that the two countries are building a relationship that will help them confront common challenges, Navy

3. ROADWAY TO THE SOUTH OF BUILDING NO. 1. AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. ROADWAY TO THE SOUTH OF BUILDING NO. 1. AT FAR LEFT IS THE SHADOW OF BUILDING NO. 6 (WAREHOUSE). ALSO VISIBLE AT THE LEFT IS BUILDING NO. 4 (BOILER HOUSE), BUILDING NO. 3 (GATE HOUSE), AND BUILDING NO. 2 (OFFICE BUILDING). IN THE RIGHT FOREGROUND IS BUILDING NO. 10 (ELECTRICAL SERVICES AND SWITCHING STATION). - United Engineering Company Shipyard, 2900 Main Street, Alameda, Alameda County, CA

Durability of building joint sealants

Treesearch

Christopher C. White; Kar Tean Tan; Donald L. Hunston; R. Sam Williams

2009-01-01

Predicting the service life of building joint sealants exposed to service environments in less than real time has been a need of the sealant community for many decades. Despite extensive research efforts to design laboratory accelerated tests to duplicate the failure modes occurring in field exposures, little success has been achieved using conventional durability...

Fire in High Buildings. Fire Study No. 21.

ERIC Educational Resources Information Center

Galbreath, M.

Research into and measures of fire protection with regard to high building design are discussed with suggestions for proper building equipment, materials, and planning. The study outlines how smoke and toxic gases spread in high buildings through stairs, service shafts, air handling and heating equipment. The problems of basement fires, means of…

Maintenance of Mechanical Services. Maintenance and Renewal in Educational Buildings. Building Bulletin 70.

ERIC Educational Resources Information Center

Haworth-Roberts, A., Ed.

School building maintenance must find an appropriate balance between planned and reactive work in order to conserve costs. This document provides ways in which authorities can assess their maintenance requirements and make better use of the resources available. It considers how to deal with problems which have their roots in historical design…

Building Community through Mentoring Adult Learners

ERIC Educational Resources Information Center

Plante, Jarrad; Truitt, Joshua

2016-01-01

The Volunteer UCF Community Connectors and Community Builders Program provides a connection between students and their community. The goal is to develop meaningful service opportunities for UCF students that contribute measurable results and systemic change through capacity building among adult learners. The ongoing, sustainable service experience…

Pharmacophore Identification, Molecular Docking, Virtual Screening, and In Silico ADME Studies of Non-Nucleoside Reverse Transcriptase Inhibitors.

PubMed

Pirhadi, Somayeh; Ghasemi, Jahan B

2012-12-01

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive place due to their unique antiviral potency, high specificity and low toxicity in antiretroviral combination therapies used to treat HIV. In this study, chemical feature based pharmacophore models of different classes of NNRT inhibitors of HIV-1 have been developed. The best HypoRefine pharmacophore model, Hypo 1, which has the best correlation coefficient (0.95) and the lowest RMS (0.97), contains two hydrogen bond acceptors, one hydrophobic and one ring aromatic feature, as well as four excluded volumes. Hypo 1 was further validated by test set and Fischer validation method. The best pharmacophore model was then utilized as a 3D search query to perform a virtual screening to retrieve potential inhibitors. The hit compounds were subsequently subjected to filtering by Lipinski's rule of five and docking studies by Libdock and Gold methods to refine the retrieved hits. Finally, 7 top ranked compounds based on Gold score fitness function were subjected to in silico ADME studies to investigate for compliance with the standard ranges. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Models of evaluating efficiency and risks on integration of cloud-base IT-services of the machine-building enterprise: a system approach

NASA Astrophysics Data System (ADS)

Razumnikov, S.; Kurmanbay, A.

2016-04-01

The present paper suggests a system approach to evaluation of the effectiveness and risks resulted from the integration of cloud-based services in a machine-building enterprise. This approach makes it possible to estimate a set of enterprise IT applications and choose the applications to be migrated to the cloud with regard to specific business requirements, a technological strategy and willingness to risk.

Building IoT Services for Aging in Place Using Standard-Based IoT Platforms and Heterogeneous IoT Products.

PubMed

Fattah, Sheik Mohammad Mostakim; Sung, Nak-Myoung; Ahn, Il-Yeup; Ryu, Minwoo; Yun, Jaeseok

2017-10-11

An aging population and human longevity is a global trend. Many developed countries are struggling with the yearly increasing healthcare cost that dominantly affects their economy. At the same time, people living with old adults suffering from a progressive brain disorder such as Alzheimer's disease are enduring even more stress and depression than those patients while caring for them. Accordingly, seniors' ability to live independently and comfortably in their current home for as long as possible has been crucial to reduce the societal cost for caregiving and thus give family members peace of mind, called 'aging in place' (AIP). In this paper we present a way of building AIP services using standard-based IoT platforms and heterogeneous IoT products. An AIP service platform is designed and created by combining previous standard-based IoT platforms in a collaborative way. A service composition tool is also created that allows people to create AIP services in an efficient way. To show practical usability of our proposed system, we choose a service scenario for medication compliance and implement a prototype service which could give old adults medication reminder appropriately at the right time (i.e., when it is time to need to take pills) through light and speaker at home but also wrist band and smartphone even outside the home.

Building IoT Services for Aging in Place Using Standard-Based IoT Platforms and Heterogeneous IoT Products

PubMed Central

Fattah, Sheik Mohammad Mostakim; Sung, Nak-Myoung; Ahn, Il-Yeup; Ryu, Minwoo; Yun, Jaeseok

2017-01-01

An aging population and human longevity is a global trend. Many developed countries are struggling with the yearly increasing healthcare cost that dominantly affects their economy. At the same time, people living with old adults suffering from a progressive brain disorder such as Alzheimer’s disease are enduring even more stress and depression than those patients while caring for them. Accordingly, seniors’ ability to live independently and comfortably in their current home for as long as possible has been crucial to reduce the societal cost for caregiving and thus give family members peace of mind, called ‘aging in place’ (AIP). In this paper we present a way of building AIP services using standard-based IoT platforms and heterogeneous IoT products. An AIP service platform is designed and created by combining previous standard-based IoT platforms in a collaborative way. A service composition tool is also created that allows people to create AIP services in an efficient way. To show practical usability of our proposed system, we choose a service scenario for medication compliance and implement a prototype service which could give old adults medication reminder appropriately at the right time (i.e., when it is time to need to take pills) through light and speaker at home but also wrist band and smartphone even outside the home. PMID:29019964

2. VIEW SOUTHEAST, WEST FRONT OF BUILDINGS 25. 26; NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW SOUTHEAST, WEST FRONT OF BUILDINGS 25. 26; NORTH FRONT OF BUILDING 24: ROOF GABLE OF BUILDING 27 - U.S. Plant Introduction Station, Soil Conservation Service Cluster, 11601 Old Pond Road, Glenn Dale, Prince George's County, MD

77 FR 40358 - Federal Management Regulation; FMR Bulletin PBS-2012-03; Redesignations of Federal Buildings...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... Management Regulation; FMR Bulletin PBS-2012-03; Redesignations of Federal Buildings: Correction AGENCY: Public Buildings Service (PBS), General Services Administration (GSA). ACTION: Notice of a bulletin..., 2012, a bulletin announcing the designation and redesignation of three Federal buildings. Inadvertently...

American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance U.S. General Services Administration – Project 195 John Seiberling Federal Office Building and U.S. Courthouse, Akron, Ohio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arends, J.; Sandusky, William F.

This report documents the findings from an onsite audit of the John Seiberling Federal building located in Akron, Ohio. The Federal landlord for this building is the General Services Administration (GSA). The focus of the audit was to identify various no-cost or low-cost energy efficiency opportunities that, once implemented, would reduce in either electrical and gas consumption and increase the operational efficiency of the building. This audit also provided an opportunity to identify potential capital cost projects that should be considered in the to acquire additional energy (electric and gas) and water savings to further increase the operational efficiency ofmore » the building.« less

Building a partnership to evaluate school-linked health services: the Cincinnati School Health Demonstration Project.

PubMed

Rose, Barbara L; Mansour, Mona; Kohake, Kelli

2005-12-01

The Cincinnati School Health Demonstration Project was a 3-year collaboration that evaluated school-linked health services in 6 urban elementary (kindergarten to eighth grade) schools. Partners from the Cincinnati Health Department, Cincinnati Public Schools, Cincinnati Children's Hospital Medical Center, and The Health Foundation of Greater Cincinnati wanted to determine if levels of school-linked care made a difference in student quality of life, school connectedness, attendance, emergency department use, and volume of referrals to health care specialists. School nurses, principals and school staff, parents and students, upper-level managers, and health service researchers worked together over a 2.5-year period to learn about and use new technology to collect information on student health, well-being, and outcome measures. Varying levels of school health care intervention models were instituted and evaluated. A standard model of care was compared with 2 models of enhanced care and service. The information collected from students, parents, nurses, and the school system provided a rich database on the health of urban children. School facilities, staffing, and computer technology, relationship building among stakeholders, extensive communication, and high student mobility were factors that influenced success and findings of the project. Funding for district-wide computerization and addition of school health staff was not secured by the end of the demonstration project; however, relationships among the partners endured and paved the way for future collaborations designed to better serve urban school children in Cincinnati.

The effects of building design on hazard of first service in Norwegian dairy cows.

PubMed

Martin, A D; Kielland, C; Nelson, S T; Østerås, O

2015-12-01

Reproductive inefficiency is one of the major production and economic constraints on modern dairy farms. The environment affects onset of ovarian activity in a cow postcalving and influences estrus behavior, which in turn affects a stockperson's ability to inseminate her at the correct time. This study used survival analysis to investigate effects of building design and animal factors on the postpartum hazard of first service (HFS) in freestall-housed Norwegian Red cows. The study was performed on 232 Norwegian dairy farms between 2004 and 2007. Data were obtained through on farm measurements and by accessing the Norwegian Dairy Herd Recording System. The final data set contained data on 38,436 calvings and 27,127 services. Univariate Cox proportional hazard analyses showed that herd size and milk yield were positively associated with HFS. Total free accessible area and free accessible area available per cow year were positively associated with the HFS, as was the number of freestalls available per cow. Cows housed on slatted floors had a lower HFS than those housed on solid floors. Conversely, cows housed on rubber floors had a higher HFS than cows on concrete floors. Dead-ending alleyways reduced the hazard of AI after calving. A multivariable Cox proportional hazards model, accounting for herd management by including a frailty term for herd, showed relationships between hazard of postpartum service and explanatory variables. Animals in herds with more than 50 cows had a higher HFS [hazard ratio (HR)=3.0] compared with those in smaller herds. The HFS was also higher (HR=4.3) if more than 8.8 m(2) of space was available per cow year compared with herds in which animals had less space. The HFS after calving increased with parity (parity 2 HR=0.5, parity ≥3 HR=1.7), and was reduced if a lactation began with dystocia (HR=0.82) or was a breed other than Norwegian Red (HR=0.2). The frailty term, herd, was large and highly significant indicating a significant

MINIMUM AREAS FOR ELEMENTARY SCHOOL BUILDING FACILITIES.

ERIC Educational Resources Information Center

Pennsylvania State Dept. of Public Instruction, Harrisburg.

MINIMUM AREA SPACE REQUIREMENTS IN SQUARE FOOTAGE FOR ELEMENTARY SCHOOL BUILDING FACILITIES ARE PRESENTED, INCLUDING FACILITIES FOR INSTRUCTIONAL USE, GENERAL USE, AND SERVICE USE. LIBRARY, CAFETERIA, KITCHEN, STORAGE, AND MULTIPURPOSE ROOMS SHOULD BE SIZED FOR THE PROJECTED ENROLLMENT OF THE BUILDING IN ACCORDANCE WITH THE PROJECTION UNDER THE…

EPA guidance on building trust in mental health services.

PubMed

Gaebel, W; Muijen, M; Baumann, A E; Bhugra, D; Wasserman, D; van der Gaag, R J; Heun, R; Zielasek, J

2014-02-01

To advance mental health care use by developing recommendations to increase trust from the general public and patients, those who have been in contact with services, those who have never been in contact and those who care for their families in the mental health care system. We performed a systematic literature search and the retrieved documents were evaluated by two independent reviewers. Evidence tables were generated and recommendations were developed in an expert and stakeholder consensus process. We developed five recommendations which may increase trust in mental health care services and advance mental health care service utilization. Trust is a mutual, complex, multidimensional and dynamic interrelationship of a multitude of factors. Its components may vary between individuals and over time. They may include, among others, age, place of residence, ethnicity, culture, experiences as a service user, and type of disorder. For mental health care services, issues of knowledge about mental health services, confidentiality, continuity of treatment, dignity, safety and avoidance of stigma and coercion are central elements to increase trust. Evidence-based recommendations to increase mutual trust of service users and psychiatrists have been developed and may help to increase mental health care service utilization. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Opportunities and Efficiencies in Building a New Service Desk Model.

PubMed

Mayo, Alexa; Brown, Everly; Harris, Ryan

2017-01-01

In July 2015, the Health Sciences and Human Services Library (HS/HSL) at the University of Maryland, Baltimore (UMB), merged its reference and circulation services, creating the Information Services Department and Information Services Desk. Designing the Information Services Desk with a team approach allowed for the re-examination of the HS/HSL's service model from the ground up. With the creation of a single service point, the HS/HSL was able to create efficiencies, improve the user experience by eliminating handoffs, create a collaborative team environment, and engage information services staff in a variety of new projects.

In vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MS(E) and control comparison: cost and benefit of vehicle-dosed control samples.

PubMed

Fiebig, Lukas; Laux, Ralf; Binder, Rudolf; Ebner, Thomas

2016-10-01

1. Liquid chromatography (LC)-high resolution mass spectrometry (HRMS) techniques proved to be well suited for the identification of predicted and unexpected drug metabolites in complex biological matrices. 2. To efficiently discriminate between drug-related and endogenous matrix compounds, however, sophisticated postacquisition data mining tools, such as control comparison techniques are needed. For preclinical absorption, distribution, metabolism and excretion (ADME) studies that usually lack a placebo-dosed control group, the question arises how high-quality control data can be yielded using only a minimum number of control animals. 3. In the present study, the combination of LC-traveling wave ion mobility separation (TWIMS)-HRMS(E) and multivariate data analysis was used to study the polymer patterns of the frequently used formulation constituents polyethylene glycol 400 and polysorbate 80 in rat plasma and urine after oral and intravenous administration, respectively. 4. Complex peak patterns of both constituents were identified underlining the general importance of a vehicle-dosed control group in ADME studies for control comparison. Furthermore, the detailed analysis of administration route, blood sampling time and gender influences on both vehicle peak pattern as well as endogenous matrix background revealed that high-quality control data is obtained when (i) control animals receive an intravenous dose of the vehicle, (ii) the blood sampling time point is the same for analyte and control sample and (iii) analyte and control samples of the same gender are compared.

Building Specifications

NASA Technical Reports Server (NTRS)

1978-01-01

building shows that, while MASTERSPEC saves time and money, its use involves no sacrfice in architectural design freedom. The Naval Engineering Facilities Command employs an automated specifications system based on SPECSINTACT. The Public Buildings Service of the General Services Administration used SPECSINTACT as a starting point in a plan to make its guideline specifications available to architects and engineers on a nationwide computer network. Public Technology, Inc., a NASA Technology Application Team, is working with Production Systems for Architects and Engineers, Inc., to promote widespread use of the system by state and local governments for cost benefits to taxpayers.

Life Cycle Energy Assessment of a Multi-storey Residential Building

NASA Astrophysics Data System (ADS)

Mehta, Sourabh; Chandur, Arjun; Palaniappan, Sivakumar

2017-06-01

This study presents the findings of life cycle energy assessment of two multi-storey residential buildings. These buildings consist of a total of 60 homes. The usable floor area is 43.14 m2 (463.36 ft2) per home. A detailed estimation of embodied energy is carried out by considering the use of materials during building construction. Major contributors of embodied energy are found to be steel, cement and aluminum. Monthly building operation energy was assessed using a total of 2520 data samples corresponding to 3 years of building operation. Analysis of a base case scenario, with 50 years of service life and average monthly operation energy, indicates that the embodied energy and the operation energy account for 16 and 84% of the life cycle energy respectively. Sensitivity analysis is carried out to study the influence of service life and operation energy on the relative contribution of embodied energy and operation energy. It is found that the embodied energy represents as high as 31% of the life cycle energy depending upon the variation in the operation energy and the service life. Hence, strategies towards sustainable building construction should also focus on reducing the embodied energy in the design and construction phases in addition to operation energy.

77 FR 6985 - General Services Administration Acquisition Regulation; Reinstatement of Coverage Pertaining to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... Claims, for releases of claims under construction and building service contracts, was inadvertently... the release of claims under construction and building service contracts. At this time, consideration... for releases of claims under construction and building service contracts, was inadvertently deleted as...

Building Geospatial Web Services for Ecological Monitoring and Forecasting

NASA Astrophysics Data System (ADS)

Hiatt, S. H.; Hashimoto, H.; Melton, F. S.; Michaelis, A. R.; Milesi, C.; Nemani, R. R.; Wang, W.

2008-12-01

The Terrestrial Observation and Prediction System (TOPS) at NASA Ames Research Center is a modeling system that generates a suite of gridded data products in near real-time that are designed to enhance management decisions related to floods, droughts, forest fires, human health, as well as crop, range, and forest production. While these data products introduce great possibilities for assisting management decisions and informing further research, realization of their full potential is complicated by their shear volume and by the need for a necessary infrastructure for remotely browsing, visualizing, and analyzing the data. In order to address these difficulties we have built an OGC-compliant WMS and WCS server based on an open source software stack that provides standardized access to our archive of data. This server is built using the open source Java library GeoTools which achieves efficient I/O and image rendering through Java Advanced Imaging. We developed spatio-temporal raster management capabilities using the PostGrid raster indexation engine. We provide visualization and browsing capabilities through a customized Ajax web interface derived from the kaMap project. This interface allows resource managers to quickly assess ecosystem conditions and identify significant trends and anomalies from within their web browser without the need to download source data or install special software. Our standardized web services also expose TOPS data to a range of potential clients, from web mapping applications to virtual globes and desktop GIS packages. However, support for managing the temporal dimension of our data is currently limited in existing software systems. Future work will attempt to overcome this shortcoming by building time-series visualization and analysis tools that can be integrated with existing geospatial software.

Detail view to show northwestern section of the building with ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view to show northwestern section of the building with its modified mansard roof - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

Reconciling Time, Space and Function: A New Dorsal-Ventral Stream Model of Sentence Comprehension

ERIC Educational Resources Information Center

Bornkessel-Schlesewsky, Ina; Schlesewsky, Matthias

2013-01-01

We present a new dorsal-ventral stream framework for language comprehension which unifies basic neurobiological assumptions (Rauschecker & Scott, 2009) with a cross-linguistic neurocognitive sentence comprehension model (eADM; Bornkessel & Schlesewsky, 2006). The dissociation between (time-dependent) syntactic structure-building and…

VIEW OF BUILDING 122 WHICH HOUSES THE ONSITE MEDICAL FACILITIES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF BUILDING 122 WHICH HOUSES THE ON-SITE MEDICAL FACILITIES OF THE ROCKY FLATS PLANT AND THE OCCUPATIONAL HEALTH AND INTERNAL DOSIMETRY ORGANIZATIONS. EMERGENCY MEDICAL SERVICES, DIAGNOSIS, DECONTAMINATION, FIRST AID, X-RAY, MINOR SURGICAL TREATMENT, AND AMBULATORY ACTIVITIES ARE CARRIED OUT IN THIS BUILDING. (1/98) - Rocky Flats Plant, Emergency Medical Services Facility, Southwest corner of Central & Third Avenues, Golden, Jefferson County, CO

10 CFR 434.518 - Service water heating.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Service water heating. 434.518 Section 434.518 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1The...

10 CFR 434.518 - Service water heating.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Service water heating. 434.518 Section 434.518 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Building Energy Cost Compliance Alternative § 434.518 Service water heating. 518.1The...

Performance evaluation of existing building structure with pushover analysis

NASA Astrophysics Data System (ADS)

Handana, MAP; Karolina, R.; Steven

2018-02-01

In the management of the infrastructure of the building, during the period of buildings common building damage as a result of several reasons, earthquakes are common. The building is planned to work for a certain service life. But during the certain service life, the building vulnerable to damage due to various things. Any damage to cultivate can be detected as early as possible, because the damage could spread, triggering and exacerbating the latest. The newest concept to earthquake engineering is Performance Based Earthquake Engineering (PBEE). PBEE divided into two, namely Performance Based Seismic Design (PBSD) and Performance Based Seismic Evaluation (PBSE). Evaluation on PBSE one of which is the analysis of nonlinear pushover. Pushover analysis is a static analysis of nonlinear where the influence of the earthquake plan on building structure is considered as burdens static catch at the center of mass of each floor, which it was increased gradually until the loading causing the melting (plastic hinge) first within the building structure, then the load increases further changes the shapes of post-elastic large it reached the condition of elastic. Then followed melting (plastic hinge) in the location of the other structured.

Integrated Building Management System (IBMS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anita Lewis

This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment withoutmore » interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.« less

KSC Headquarters Building Groundbreaking Ceremony

NASA Image and Video Library

2014-10-07

Groundbreaking for the new Central Campus took place in the Industrial Area at NASA's Kennedy Space Center in Florida. Steve Belflower, vice president of HuntonBrady Architects of Orlando, points to a scale model of the Central Campus building on display during the groundbreaking ceremony. Kennedy is transforming into a multi-user, 21st century spaceport supporting both commercial and government users and operations. Central Campus Phase I includes construction of a new Headquarters Building as one of the major components of the strategy. The new Headquarters Building will be a seven-story, 200,000-square-foot facility that will house about 500 NASA civil service and contractor employees.

Disparities in Alcohol, Drug Use, and Mental Health Condition Prevalence and Access to Care in Rural, Isolated, and Reservation Areas: Findings From the South Dakota Health Survey.

PubMed

Davis, Melinda M; Spurlock, Margaret; Dulacki, Kristen; Meath, Thomas; Li, Hsin-Fang Grace; McCarty, Dennis; Warne, Donald; Wright, Bill; McConnell, K John

2016-06-01

Research on urban/rural disparities in alcohol, drug use, and mental health (ADM) conditions is inconsistent. This study describes ADM condition prevalence and access to care across diverse geographies in a predominantly rural state. Multimodal cross-sectional survey in South Dakota from November 2013 to October 2014, with oversampling in rural areas and American Indian reservations. Measures assessed demographic characteristics, ADM condition prevalence using clinical screenings and participant self-report, perceived need for treatment, health service usage, and barriers to obtaining care. We tested for differences among urban, rural, isolated, and reservation geographic areas, controlling for participant age and gender. We analyzed 7,675 surveys (48% response rate). Generally, ADM condition prevalence rates were not significantly different across geographies. However, respondents in isolated and reservation areas were significantly less likely to have access to primary care. Knowledge of treatment options was significantly lower in isolated regions and individuals in reservation areas had significantly lower odds of reporting receipt of all needed care. Across the sample there was substantial discordance between ADM clinical screenings and participant self-reported need; 98.1% of respondents who screened positive for alcohol or drug misuse and 63.8% of respondents who screened positive for a mental health condition did not perceive a need for care. In a predominantly rural state, geographic disparities in ADM conditions are related to differences in access as opposed to prevalence, particularly for individuals in isolated and reservation areas. Educational interventions about ADM condition characteristics may be as important as improving access to care. © 2015 National Rural Health Association.

Building Team Belay

DTIC Science & Technology

2014-09-01

information, including suggestions for reducing this burden, to Washington headquarters Services, Directorate for Information Operations and Reports... remunerations actuating one to conform to group mores.6 4 Institute of Medicine, Building a... remunerations actuating one to conform to group mores. The social support that is elemental among “home” emergency response teams can be viewed and

Consolidated Afloat Networks and Enterprise Services (CANES)

DTIC Science & Technology

2016-03-01

Executive DoD - Department of Defense DoDAF - DoD Architecture Framework FD - Full Deployment FDD - Full Deployment Decision FY - Fiscal Year IA...Deployment Decision Jun 2015 Oct 2015 Full Deployment1 Sep 2024 Sep 2023 Memo 1/ Per the FDD ADM approved by USD(AT&L) on October 13, 2015, the FD date was

4. VIEW LOOKING NORTHWEST OF FUEL HANDLING BUILDING (CENTER), REACTOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW LOOKING NORTHWEST OF FUEL HANDLING BUILDING (CENTER), REACTOR SERVICE BUILDING (RIGHT), MACHINE SHOP (LEFT) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

Detail of north facades of (left to right) Building 86813 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of north facades of (left to right) Building 8-6813 and Building 8-6811; view to southeast - Fort Bragg, Noncommissioned Officers' Service Club, South of Butner Road, Fayetteville, Cumberland County, NC

Building Essential Skills for the Ohio Building and Construction Industry. Final Report.

ERIC Educational Resources Information Center

Pritz, Sandra G.; And Others

The Center on Education and Training for Employment (CETE) at the Ohio State University worked in partnership with the Ohio State Building and Construction Trades Council (OSB&CT) to develop and deliver customized workplace literacy services for local union members in six major Ohio cities (Columbus, Cleveland, Cincinnati, Toledo, Dayton, and…

Re-conceiving building design quality: A review of building users in their social context.

PubMed

Watson, Kelly J; Evans, James; Karvonen, Andrew; Whitley, Tim

2016-05-01

Considerable overlap exists between post-occupancy research evaluating building design quality and the concept of 'social value', popularised by its recent application to issues of the public realm. To outline this potential research agenda, the paper reviews design quality research on buildings in relation to users and their social context where the term 'social context' refers to building user group dynamics, a combination of organisational cultures, management strategies, and social norms and practices. The review is conducted across five key building types, namely housing, workplaces, healthcare, education, and the retail/service sector. Research commonalities and gaps are identified in order to build a more comprehensive picture of the design quality literature and its handling of users in their social context. The key findings concerning each building type are presented visually. It is concluded that the design quality field comprises a patchwork of relatively isolated studies of various building types, with significant potential for theoretical and empirical development through interdisciplinary collaboration. Users tend to be conceived as anonymous and autonomous individuals with little analysis of user identity or interaction. Further, the contextual impact of user group dynamics on the relationship between building design and building user is rarely addressed in the literature. Producing a more nuanced understanding of users in situ is proposed as an important area for future design quality research.

Re-conceiving building design quality: A review of building users in their social context

PubMed Central

Evans, James; Karvonen, Andrew; Whitley, Tim

2014-01-01

Considerable overlap exists between post-occupancy research evaluating building design quality and the concept of ‘social value’, popularised by its recent application to issues of the public realm. To outline this potential research agenda, the paper reviews design quality research on buildings in relation to users and their social context where the term ‘social context’ refers to building user group dynamics, a combination of organisational cultures, management strategies, and social norms and practices. The review is conducted across five key building types, namely housing, workplaces, healthcare, education, and the retail/service sector. Research commonalities and gaps are identified in order to build a more comprehensive picture of the design quality literature and its handling of users in their social context. The key findings concerning each building type are presented visually. It is concluded that the design quality field comprises a patchwork of relatively isolated studies of various building types, with significant potential for theoretical and empirical development through interdisciplinary collaboration. Users tend to be conceived as anonymous and autonomous individuals with little analysis of user identity or interaction. Further, the contextual impact of user group dynamics on the relationship between building design and building user is rarely addressed in the literature. Producing a more nuanced understanding of users in situ is proposed as an important area for future design quality research. PMID:27110217

78 FR 1735 - Airworthiness Directives; Honeywell International Inc. Air Data Pressure Transducers

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... reviewed Honeywell Alert Service Bulletin ADM/ADC/ADAHRS-34-A01, dated November 6, 2012. This service...), air data computers, air data attitude heading reference systems, and digital air data computers... fails. Honeywell Service Bulletin ACM/ADC/ADAHRS-34-A01, dated November 6, 2012, specifies to refer to...

Advanced information processing system: Local system services

NASA Technical Reports Server (NTRS)

Burkhardt, Laura; Alger, Linda; Whittredge, Roy; Stasiowski, Peter

1989-01-01

The Advanced Information Processing System (AIPS) is a multi-computer architecture composed of hardware and software building blocks that can be configured to meet a broad range of application requirements. The hardware building blocks are fault-tolerant, general-purpose computers, fault-and damage-tolerant networks (both computer and input/output), and interfaces between the networks and the computers. The software building blocks are the major software functions: local system services, input/output, system services, inter-computer system services, and the system manager. The foundation of the local system services is an operating system with the functions required for a traditional real-time multi-tasking computer, such as task scheduling, inter-task communication, memory management, interrupt handling, and time maintenance. Resting on this foundation are the redundancy management functions necessary in a redundant computer and the status reporting functions required for an operator interface. The functional requirements, functional design and detailed specifications for all the local system services are documented.

Capacity building in indigenous men's groups and sheds across Australia.

PubMed

Southcombe, Amie; Cavanagh, Jillian; Bartram, Timothy

2015-09-01

This article presents an investigation into capacity building, at the community level, in Aboriginal and Torres Strait Islander Men's Groups and Sheds. As safe men's spaces, Men's Groups and Sheds represent an ever-growing social, and health and well-being community service across Australia. The study is qualitative and employs 'yarning circles' (focus groups), semi-structured interviews and observations to gather data from 15 Groups/Sheds involving 45 men from urban, regional and remote communities. We found that capacity building is primarily about securing relationships between Group Leaders/Shed Co-ordinators and Government services. Capacity building establishes links to services such as Centrelink, Medicare, Department of Housing, Probation and Control, and positive outcomes such as Indigenous men securing housing and Centrelink payments. Capacity building results in better health outcomes and, educates and empowers men to improve their social, cultural, emotional and economic well-being. It helps men to better connect with family and community. The current research paves the way for countries worldwide to explore the conceptual and empirical approach of capacity building applicable to other Indigenous [and non-Indigenous] Men's Groups/Sheds. We recommend feasibilities studies, on approaches to capacity building in Indigenous Groups/Sheds, be carried out within urban, regional and remote regions across the country. © The Author (2014). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A decade of building massage therapy services at an academic medical center as part of a healing enhancement program.

PubMed

Rodgers, Nancy J; Cutshall, Susanne M; Dion, Liza J; Dreyer, Nikol E; Hauschulz, Jennifer L; Ristau, Crystal R; Thomley, Barb S; Bauer, Brent A

2015-02-01

The use of complementary and integrative medicine therapies is steadily becoming an integral part of health care. Massage therapy is increasingly offered to hospitalized patients for various conditions to assist with the management of common symptoms such as pain, anxiety, and tension. This article summarizes a decade of building the massage therapy service at a large tertiary care medical center, from the early pilot studies and research to the current program offerings, and the hopes and dreams for the future. Copyright © 2014 Elsevier Ltd. All rights reserved.

Mental health care reforms in Asia: the urgency of now: building a recovery-oriented, community mental health service in china.

PubMed

Tse, Samson; Ran, Mao-Sheng; Huang, Yueqin; Zhu, Shimin

2013-07-01

For the first time in history, China has a mental health legal framework. People in China can now expect a better life and more accessible, better-quality health care services for their loved ones. Development of a community mental health service (CMHS) is at a crossroads. In this new column on mental health reforms in Asia, the authors review the current state of the CMHS in China and propose four strategic directions for future development: building on the strengths of the "686 Project," the 2004 initiative that launched China's mental health reform; improving professional skills of the mental health workforce, especially for a recovery approach; empowering families and caregivers to support individuals with severe mental illness; and using information and communications technology to promote self-help and reduce the stigma associated with psychiatric disorders.

Data management for biofied building

NASA Astrophysics Data System (ADS)

Matsuura, Kohta; Mita, Akira

2015-03-01

Recently, Smart houses have been studied by many researchers to satisfy individual demands of residents. However, they are not feasible yet as they are very costly and require many sensors to be embedded into houses. Therefore, we suggest "Biofied Building". In Biofied Building, sensor agent robots conduct sensing, actuation, and control in their house. The robots monitor many parameters of human lives such as walking postures and emotion continuously. In this paper, a prototype network system and a data model for practical application for Biofied Building is pro-posed. In the system, functions of robots and servers are divided according to service flows in Biofield Buildings. The data model is designed to accumulate both the building data and the residents' data. Data sent from the robots and data analyzed in the servers are automatically registered into the database. Lastly, feasibility of this system is verified through lighting control simulation performed in an office space.

School Building Design and Audio-Visual Resources.

ERIC Educational Resources Information Center

National Committee for Audio-Visual Aids in Education, London (England).

The design of new schools should facilitate the use of audiovisual resources by ensuring that the materials used in the construction of the buildings provide adequate sound insulation and acoustical and viewing conditions in all learning spaces. The facilities to be considered are: electrical services; electronic services; light control and…

21. Perimeter acquisition radar building room #200, electrical equipment room ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Perimeter acquisition radar building room #200, electrical equipment room - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

35. Perimeter acquisition radar building room #325, showing hard disc ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. Perimeter acquisition radar building room #325, showing hard disc drive - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

Utilization of structural steel in buildings.

PubMed

Moynihan, Muiris C; Allwood, Julian M

2014-08-08

Over one-quarter of steel produced annually is used in the construction of buildings. Making this steel causes carbon dioxide emissions, which climate change experts recommend be reduced by half in the next 37 years. One option to achieve this is to design and build more efficiently, still delivering the same service from buildings but using less steel to do so. To estimate how much steel could be saved from this option, 23 steel-framed building designs are studied, sourced from leading UK engineering firms. The utilization of each beam is found and buildings are analysed to find patterns. The results for over 10 000 beams show that average utilization is below 50% of their capacity. The primary reason for this low value is 'rationalization'-providing extra material to reduce labour costs. By designing for minimum material rather than minimum cost, steel use in buildings could be drastically reduced, leading to an equivalent reduction in 'embodied' carbon emissions.

Utilization of structural steel in buildings

PubMed Central

Moynihan, Muiris C.; Allwood, Julian M.

2014-01-01

Over one-quarter of steel produced annually is used in the construction of buildings. Making this steel causes carbon dioxide emissions, which climate change experts recommend be reduced by half in the next 37 years. One option to achieve this is to design and build more efficiently, still delivering the same service from buildings but using less steel to do so. To estimate how much steel could be saved from this option, 23 steel-framed building designs are studied, sourced from leading UK engineering firms. The utilization of each beam is found and buildings are analysed to find patterns. The results for over 10 000 beams show that average utilization is below 50% of their capacity. The primary reason for this low value is ‘rationalization’—providing extra material to reduce labour costs. By designing for minimum material rather than minimum cost, steel use in buildings could be drastically reduced, leading to an equivalent reduction in ‘embodied’ carbon emissions. PMID:25104911

78 FR 59817 - Revision to United States Marshals Service Fees for Services

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

.... Federal Cost Accounting and Fee Setting Standards and Guidelines Being Used When developing fees for... imputed rents on land, buildings, and equipment;'' (c) ``management and supervisory costs;'' and (d... current costs to the United States Marshals Service for service of process in federal court proceedings. A...

Super Kitchen Centralizes Food Service

ERIC Educational Resources Information Center

Modern Schools, 1975

1975-01-01

To centralize food service within the entire Pittsburgh school district, a 90,000-square-foot food service preparation building contains cranes and monorails to move 500-pound capacity vats throughout the kitchen. (Author/MLF)

REGIONAL COORDINATION OF NOAA/NATIONAL WEATHER SERVICE CLIMATE SERVICES IN THE WEST (Invited)

NASA Astrophysics Data System (ADS)

Bair, A.

2009-12-01

The climate services program is an important component in the National Weather Service’s (NWS) mission, and is one of the National Oceanic and Atmospheric Administration’s (NOAA) top five priorities. The Western Region NWS started building a regional and local climate services program in late 2001, with input from local NWS offices and key partners. The original goals of the Western Region climate services program were to strive to provide climate services that were useful, easily accessible, well understood, coordinated and supported by partners, and reflect customer needs. While the program has evolved, and lessons have been learned, these goals are still guiding the program. Regional and local level Climate Services are a fundamental part of NOAA/NWS’s current and future role in providing climate services. There is an ever growing demand for climate information and services to aid the public in decision-making and no single entity alone can provide the range of information and services needed. Coordination and building strong partnerships at the local and regional levels is the key to providing optimal climate services. Over the past 8 years, Western Region NWS has embarked on numerous coordination efforts to build the regional and local climate services programs, such as: collaboration (both internally and externally to NOAA) meetings and projects, internal staff training, surveys, and outreach efforts. In order to gain regional and local buy-in from the NWS staff, multiple committees were utilized to plan and develop goals and structure for the program. While the regional and local climate services program in the NWS Western Region has had many successes, there have been several important lessons learned from efforts that have not been as successful. These lessons, along with past experience, close coordination with partners, and the need to constantly improve/change the program as the climate changes, form the basis for future program development and

Building Psychological Health: The Services’ Perspectives on Resilience

DTIC Science & Technology

2011-01-24

program; medical supported • Doctrine signed Dec 2010 • Training: > 200,000 trained to date • 8 courses on Navy eLearning • Formal curriculum delivered...Address future concerns and build psychological resiliency 10 Reserve Resilience Initiatives 2011 MHS Conference NSW Resilience Enterprise  Resilience

SPGM Moves to Building 434 This Month | Poster

Cancer.gov

By Ashley DeVine, Staff Writer Scientific Publications, Graphics & Media (SPGM) moves to a new location this month—Building 434. The entrance is located on Wood Street. The move will take place between Monday, February 24, and Friday, February 28. During the move, SPGM will limit disruptions to service as much as possible. A sign in front of the building will direct you to the department’s new location. Please visit SPGM in Building 434 beginning Monday, March 3.

29 CFR 779.355 - Classification of lumber and building materials sales.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Classification of lumber and building materials sales. 779... Service Establishments Lumber and Building Materials Dealers § 779.355 Classification of lumber and building materials sales. (a) General. In determining, for purposes of the section 13(a)(2) and (4...

29 CFR 779.355 - Classification of lumber and building materials sales.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Classification of lumber and building materials sales. 779... Service Establishments Lumber and Building Materials Dealers § 779.355 Classification of lumber and building materials sales. (a) General. In determining, for purposes of the section 13(a)(2) and (4...

29 CFR 779.355 - Classification of lumber and building materials sales.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Classification of lumber and building materials sales. 779... Service Establishments Lumber and Building Materials Dealers § 779.355 Classification of lumber and building materials sales. (a) General. In determining, for purposes of the section 13(a)(2) and (4...

30. Perimeter acquisition radar building room #318, showing radar control. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Perimeter acquisition radar building room #318, showing radar control. Console and line printers - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

Skills, systems and supports: An Aboriginal Community Controlled Health Service (Apunipima) approach to building health promotion evaluation capacity of staff.

PubMed

Nichols, Nina; McFarlane, Kathryn; Gibson, Priscilla; Millard, Fiona; Packer, Andrew; McDonald, Malcolm

2018-04-01

Building the health promotion evaluation capacity of a workforce requires more than a focus on individual skills and confidence. We must also consider the organisational systems and supports that enable staff to embed learnings into practice. This paper describes the processes used to build health promotion evaluation capacity of staff in an Aboriginal Community Controlled Health Service (ACCHS). To build health promotion evaluation capacity three approaches were used: (i) workshops and mentoring; (ii) strengthening systems to support program reporting; and (iii) recruitment of staff with skills and experience. Pre- and post-questionnaires determined levels of individual skills and confidence, updated systems were assessed for adequacy to support new health promotion practices and surveys captured the usefulness of workshops and mentoring. There was increased participant skills and confidence. Participants completed program impact evaluation reports and results were successfully presented at national conferences. The health promotion team was then able to update in-house systems to support new health promotion practices. Ongoing collaboration with experienced in-house researchers provided basic research training and professional mentoring. Building health promotion evaluation capacity of staff in an ACCHS can be achieved by providing individual skill development, strengthening organisational systems and utilising professional support. SO WHAT?: Health promotion practitioners have an ongoing professional obligation to improve the quality of routine practice and embrace new initiatives. This report outlines a process of building evaluation capacity that promotes quality reporting of program impacts and outcomes, reflects on ways to enhance program strengths, and communicates these findings internally and to outside professional bodies. This is particularly significant for ACCHSs responsible for addressing the high burden of preventable disease in Aboriginal and

KSC Headquarters Building Groundbreaking Ceremony

NASA Image and Video Library

2014-10-07

Groundbreaking for the new Central Campus took place in the Industrial Area at NASA's Kennedy Space Center in Florida. Members of the media and guests gathered for the groundbreaking ceremony. Kennedy is transforming into a multi-user, 21st century spaceport supporting both commercial and government users and operations. Central Campus Phase I includes construction of a new Headquarters Building as one of the major components of the strategy. The new Headquarters Building will be a seven-story, 200,000-square-foot facility that will house about 500 NASA civil service and contractor employees.

78 FR 27968 - Federal Management Regulation; Redesignations of Federal Buildings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-13

... Buildings Service (PBS), 1800 F Street NW., Washington, DC 20405, telephone number: 202-501-1100. Dan...-501-1100. Dan Tangherlini, Acting Administrator of General Services. [FR Doc. 2013-11247 Filed 5-10-13...

View from northeast to southwest of remote launch operations building, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View from northeast to southwest of remote launch operations building, showing (left to right) diesel exhaust, diesel intake, and entrance tunnel - Stanley R. Mickelsen Safeguard Complex, Remote Launch Operations Building, Near Service Road exit from Patrol Road, Nekoma, Cavalier County, ND

EXTERIOR VIEW, FRONT (NORTH) ELEVATION. THIS THREESTORY BRICK BUILDING WITH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

EXTERIOR VIEW, FRONT (NORTH) ELEVATION. THIS THREE-STORY BRICK BUILDING WITH DEEPLY-BRACKETED AND OVERHANGING EAVES INCLUDES MULTIPLE BAYS CONSTRUCTED BEGINNING IN 1913 TO SERVE AS A 'CIVIC CENTER' FOR ACIPCO EMPLOYEES AND THEIR FAMILIES. THE BUILDING CURRENTLY INCLUDES THE TIME OFFICE, CAFETERIA, AND AUDITORIUM. - American Cast Iron Pipe Company, Service Building, 1501 Thirty-first Avenue North, Birmingham, Jefferson County, AL

Building a Comprehensive Mental Health System for Young Children

ERIC Educational Resources Information Center

Onunaku, Ngozi; Gilkerson, Linda; Ahlers, Therese

2006-01-01

Onunaku, Ahlers, and Gilkerson describe Illinois's effort to build infant mental health capacity within the Part C Early Intervention system and Wisconsin's effort to build capacity for infant and early childhood mental health services statewide across all systems that serve children. Because of multiple funding streams, families often experience…

4. VIEW NORTHWEST, NORTH FRONT OF SOIL CONSERVATION SERVICE CLUSTER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW NORTHWEST, NORTH FRONT OF SOIL CONSERVATION SERVICE CLUSTER (BUILDINGS 24, 25, 26); NORTH FRONT OF QUARANTINE HEADHOUSE (BUILDING 27) - U.S. Plant Introduction Station, Soil Conservation Service Cluster, 11601 Old Pond Road, Glenn Dale, Prince George's County, MD

Certification of building thermographers: experiences after three courses

NASA Astrophysics Data System (ADS)

Kauppinen, Timo; Hekkanen, Martti; Paloniitty, Sauli; Krankka, Juha

2006-04-01

The certification procedure of building thermographers was started in 2003, even though thermography has been used in Finland in building survey since late 70's. There has been about a 25 years' unorganized and more or less wild period, without any generally accepted rules for interpretation, as well as how to order thermography services, how to report the results, how to do the practical work in the buildings etc. The service was provided by consultants with varied backgrounds. More operators have come into the market and building developers and contractors have begun to use thermography for quality control in new building and in renovation planning. In the year 2004 various organizations in building trade launched a pilot project to certificate building thermographers. The structure and the topics of the course were introduced in Thermosense 2005. By the end of the year 2005 the third course was completed. From the beginning of the procedure to the end of the third course about 40 persons have received a certificate. During the certification process, two guidelines have been published, as part of RT (Building Information) - files: instructions for ordering, for practical field work and for reporting of thermography survey in buildings. The guidelines also contain basics for interpretation. The interpretation is consistent with the other existing directions (building codes etc). At the turn of 2005 - 2006 a new book of building thermography was published. There is still lack of comprehensive as well as unambiguous rules for interpretation. In the paper we will present experiences on the courses, the main problems posed to the participants and findings during the last two - three years' field work. We will also introduce briefly the structure and content of the guidelines and an example how to use thermography as a tool of quality control in new building. The case studies are new one-family houses in a housing fair and exhibition area in the city of Oulu.

Metrics for building performance assurance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koles, G.; Hitchcock, R.; Sherman, M.

This report documents part of the work performed in phase I of a Laboratory Directors Research and Development (LDRD) funded project entitled Building Performance Assurances (BPA). The focus of the BPA effort is to transform the way buildings are built and operated in order to improve building performance by facilitating or providing tools, infrastructure, and information. The efforts described herein focus on the development of metrics with which to evaluate building performance and for which information and optimization tools need to be developed. The classes of building performance metrics reviewed are (1) Building Services (2) First Costs, (3) Operating Costs,more » (4) Maintenance Costs, and (5) Energy and Environmental Factors. The first category defines the direct benefits associated with buildings; the next three are different kinds of costs associated with providing those benefits; the last category includes concerns that are broader than direct costs and benefits to the building owner and building occupants. The level of detail of the various issues reflect the current state of knowledge in those scientific areas and the ability of the to determine that state of knowledge, rather than directly reflecting the importance of these issues; it intentionally does not specifically focus on energy issues. The report describes work in progress and is intended as a resource and can be used to indicate the areas needing more investigation. Other reports on BPA activities are also available.« less

Building Energy Monitoring and Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hong, Tianzhen; Feng, Wei; Lu, Alison

U.S. and China are the world’s top two economics. Together they consumed one-third of the world’s primary energy. It is an unprecedented opportunity and challenge for governments, researchers and industries in both countries to join together to address energy issues and global climate change. Such joint collaboration has huge potential in creating new jobs in energy technologies and services. Buildings in the US and China consumed about 40% and 25% of the primary energy in both countries in 2010 respectively. Worldwide, the building sector is the largest contributor to the greenhouse gas emission. Better understanding and improving the energy performancemore » of buildings is a critical step towards sustainable development and mitigation of global climate change. This project aimed to develop a standard methodology for building energy data definition, collection, presentation, and analysis; apply the developed methods to a standardized energy monitoring platform, including hardware and software, to collect and analyze building energy use data; and compile offline statistical data and online real-time data in both countries for fully understanding the current status of building energy use. This helps decode the driving forces behind the discrepancy of building energy use between the two countries; identify gaps and deficiencies of current building energy monitoring, data collection, and analysis; and create knowledge and tools to collect and analyze good building energy data to provide valuable and actionable information for key stakeholders.« less

Big data analytics in the building industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berger, Michael A.; Mathew, Paul A.; Walter, Travis

Catalyzed by recent market, technology, and policy trends, energy data collection in the building industry is becoming more widespread. This wealth of information allows more data-driven decision-making by designers, commissioning agents, facilities staff, and energy service providers during the course of building design, operation and retrofit. The U.S. Department of Energy’s Building Performance Database (BPD) has taken advantage of this wealth of building asset- and energy-related data by collecting, cleansing, and standardizing data from across the U.S. on over 870,00 buildings, and is designed to support building benchmarking, energy efficiency project design, and buildings-related policy development with real-world data. Here,more » this article explores the promises and perils energy professionals are faced with when leveraging such tools, presenting example analyses for commercial and residential buildings, highlighting potential issues, and discussing solutions and best practices that will enable designers, operators and commissioning agents to make the most of ‘big data’ resources such as the BPD.« less

Big data analytics in the building industry

DOE PAGES

Berger, Michael A.; Mathew, Paul A.; Walter, Travis

2016-07-01

Catalyzed by recent market, technology, and policy trends, energy data collection in the building industry is becoming more widespread. This wealth of information allows more data-driven decision-making by designers, commissioning agents, facilities staff, and energy service providers during the course of building design, operation and retrofit. The U.S. Department of Energy’s Building Performance Database (BPD) has taken advantage of this wealth of building asset- and energy-related data by collecting, cleansing, and standardizing data from across the U.S. on over 870,00 buildings, and is designed to support building benchmarking, energy efficiency project design, and buildings-related policy development with real-world data. Here,more » this article explores the promises and perils energy professionals are faced with when leveraging such tools, presenting example analyses for commercial and residential buildings, highlighting potential issues, and discussing solutions and best practices that will enable designers, operators and commissioning agents to make the most of ‘big data’ resources such as the BPD.« less

20. Perimeter acquisition radar building room #105, shockisolated platform for ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Perimeter acquisition radar building room #105, shock-isolated platform for chillers is easily seen on the right - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

Corporate Delivery of a Global Smart Buildings Program

DOE PAGES

Fernandes, Samuel; Granderson, Jessica; Singla, Rupam; ...

2017-11-22

Buildings account for about 40 percent of the total energy consumption in the U.S. and emit approximately one third of greenhouse gas emissions. But they also offer tremendous potential for achieving significant greenhouse gas reductions with the right savings strategies. With an increasing amount of data from buildings and advanced computational and analytical abilities, buildings can be made “smart” to optimize energy consumption and occupant comfort. Smart buildings are often characterized as having a high degree of data and system integration, connectivity and control, as well as the advanced use of data analytics. These “smarts” can enable up to 10–20%more » savings in a building, and help ensure that they persist over time. In 2009, Microsoft Corporation launched the Energy-Smart Buildings (ESB) program with a vision to improve building operations services, security and accessibility in services, and new tenant applications and services that improve productivity and optimize energy use. The ESB program focused on fault diagnostics, advanced analytics and new organizational processes and practices to support their operational integration. In addition to the ESB program, Microsoft undertook capital improvement projects that made effective use of a utility incentive program and lab consolidations over the same duration. The ESB program began with a pilot at Microsoft's Puget Sound campus that identified significant savings of up to 6–10% in the 13 pilot buildings. The success of the pilot led to a global deployment of the program. Between 2009 and 2015, there was a 23.7% reduction in annual electricity consumption (kWh) at the Puget Sound campus with 18.5% of that resulting from the ESB and lab consolidations. This article provides the results of research conducted to assess the best-practice strategies that Microsoft implemented to achieve these savings, including the fault diagnostic routines that are the foundation of the ESB program and

Corporate Delivery of a Global Smart Buildings Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fernandes, Samuel; Granderson, Jessica; Singla, Rupam

Buildings account for about 40 percent of the total energy consumption in the U.S. and emit approximately one third of greenhouse gas emissions. But they also offer tremendous potential for achieving significant greenhouse gas reductions with the right savings strategies. With an increasing amount of data from buildings and advanced computational and analytical abilities, buildings can be made “smart” to optimize energy consumption and occupant comfort. Smart buildings are often characterized as having a high degree of data and system integration, connectivity and control, as well as the advanced use of data analytics. These “smarts” can enable up to 10–20%more » savings in a building, and help ensure that they persist over time. In 2009, Microsoft Corporation launched the Energy-Smart Buildings (ESB) program with a vision to improve building operations services, security and accessibility in services, and new tenant applications and services that improve productivity and optimize energy use. The ESB program focused on fault diagnostics, advanced analytics and new organizational processes and practices to support their operational integration. In addition to the ESB program, Microsoft undertook capital improvement projects that made effective use of a utility incentive program and lab consolidations over the same duration. The ESB program began with a pilot at Microsoft's Puget Sound campus that identified significant savings of up to 6–10% in the 13 pilot buildings. The success of the pilot led to a global deployment of the program. Between 2009 and 2015, there was a 23.7% reduction in annual electricity consumption (kWh) at the Puget Sound campus with 18.5% of that resulting from the ESB and lab consolidations. This article provides the results of research conducted to assess the best-practice strategies that Microsoft implemented to achieve these savings, including the fault diagnostic routines that are the foundation of the ESB program and

21 CFR 226.20 - Buildings.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Buildings. 226.20 Section 226.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... insecticides, fungicides, rodenticides, or other pesticides or their components unless such materials are...

21 CFR 226.20 - Buildings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Buildings. 226.20 Section 226.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR TYPE A MEDICATED ARTICLES Construction and Maintenance of...

Building-Based Analysis of the Spatial Provision of Urban Parks in Shenzhen, China.

PubMed

Gao, Wenxiu; Lyu, Qiang; Fan, Xiang; Yang, Xiaochun; Liu, Jiangtao; Zhang, Xirui

2017-12-06

Urban parks provide important environmental, social, and economic benefits to people and urban areas. The literature demonstrates that proximity to urban parks is one of the key factors influencing people's willingness to use them. Therefore, the provision of urban parks near residential areas and workplaces is one of the key factors influencing quality of life. This study designed a solution based on the spatial association between urban parks and buildings where people live or work to identify whether people in different buildings have nearby urban parks available for their daily lives. A building density map based on building floor area (BFA) was used to illustrate the spatial distribution of urban parks and five indices were designed to measure the scales, service coverage and potential service loads of urban parks and reveal areas lacking urban park services in an acceptable walking distance. With such solution, we investigated the provision of urban parks in ten districts of Shenzhen in China, which has grown from several small villages to a megacity in only 30 years. The results indicate that the spatial provision of urban parks in Shenzhen is not sufficient since people in about 65% of the buildings cannot access urban parks by walking 10-min. The distribution and service coverage of the existing urban parks is not balanced at the district level. In some districts, the existing urban parks have good numbers of potential users and even have large service loads, while in some districts, the building densities surrounding the existing parks are quite low and at the same time there is no urban parks nearby some high-density areas.

Building-Based Analysis of the Spatial Provision of Urban Parks in Shenzhen, China

PubMed Central

Gao, Wenxiu; Lyu, Qiang; Fan, Xiang; Liu, Jiangtao; Zhang, Xirui

2017-01-01

Urban parks provide important environmental, social, and economic benefits to people and urban areas. The literature demonstrates that proximity to urban parks is one of the key factors influencing people’s willingness to use them. Therefore, the provision of urban parks near residential areas and workplaces is one of the key factors influencing quality of life. This study designed a solution based on the spatial association between urban parks and buildings where people live or work to identify whether people in different buildings have nearby urban parks available for their daily lives. A building density map based on building floor area (BFA) was used to illustrate the spatial distribution of urban parks and five indices were designed to measure the scales, service coverage and potential service loads of urban parks and reveal areas lacking urban park services in an acceptable walking distance. With such solution, we investigated the provision of urban parks in ten districts of Shenzhen in China, which has grown from several small villages to a megacity in only 30 years. The results indicate that the spatial provision of urban parks in Shenzhen is not sufficient since people in about 65% of the buildings cannot access urban parks by walking 10-min. The distribution and service coverage of the existing urban parks is not balanced at the district level. In some districts, the existing urban parks have good numbers of potential users and even have large service loads, while in some districts, the building densities surrounding the existing parks are quite low and at the same time there is no urban parks nearby some high-density areas. PMID:29211046

29. Perimeter acquisition radar building room #318, data processing system ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. Perimeter acquisition radar building room #318, data processing system area; data processor maintenance and operations center, showing data processing consoles - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

5. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

11. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

7. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

12. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

10. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

6. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

14. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

8. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

13. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

9. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

4. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey ARCHITECT'S DRAWING Copy negative from book published by Secretary of Treasury, 1857, consisting of 21 plates. In office of the Building Manager, General Services Administration, New Orleans - U.S. Custom House, 423 Canal Street, New Orleans, Orleans Parish, LA

31. Perimeter acquisition radar building room #318, data storage "racks"; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

31. Perimeter acquisition radar building room #318, data storage "racks"; sign read: M&D controller, logic control buffer, data transmission controller - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

NOAA's Regional Climate Services Program: Building Relationships with Partners and Customers to Deliver Trusted Climate Information at Usable Scales

NASA Astrophysics Data System (ADS)

Mecray, E. L.; Dissen, J.

2016-12-01

Federal agencies across multiple sectors from transportation to health, emergency management and agriculture, are now requiring their key stakeholders to identify and plan for climate-related impacts. Responding to the drumbeat for climate services at the regional and local scale, the National Oceanic and Atmospheric Administration (NOAA) formed its Regional Climate Services (RCS) program to include Regional Climate Services Directors (RCSD), Regional Climate Centers, and state climatologists in a partnership. Since 2010, the RCS program has engaged customers across the country and amongst many of the nation's key economic sectors to compile information requirements, deliver climate-related products and services, and build partnerships among federal agencies and their regional climate entities. The talk will include a sketch from the Eastern Region that may shed light on the interaction of the multiple entities working at the regional scale. Additionally, we will show examples of our interagency work with the Department of Interior, the Department of Agriculture, and others in NOAA to deliver usable and trusted climate information and resources. These include webinars, print material, and face-to-face customer engagements to gather and respond to information requirements. NOAA/National Centers for Environmental Information's RCSDs work on-the-ground to learn from customers about their information needs and their use of existing tools and resources. As regional leads, the RCSDs work within NOAA and with our regional partners to ensure the customer receives a broad picture of the tools and information from across the nation.

Empowering Young People through Service

ERIC Educational Resources Information Center

Kapp, Amy

2009-01-01

Each year, more than 200 students at YouthBuild Philadelphia Charter School in Pennsylvania make a commitment to help improve Philadelphia's neighborhoods as they work toward their high school diplomas. Since YouthBuild Philadelphia's inception in 1992, students have provided a wide variety of volunteer services to families and organizations…

BioServices: a common Python package to access biological Web Services programmatically.

PubMed

Cokelaer, Thomas; Pultz, Dennis; Harder, Lea M; Serra-Musach, Jordi; Saez-Rodriguez, Julio

2013-12-15

Web interfaces provide access to numerous biological databases. Many can be accessed to in a programmatic way thanks to Web Services. Building applications that combine several of them would benefit from a single framework. BioServices is a comprehensive Python framework that provides programmatic access to major bioinformatics Web Services (e.g. KEGG, UniProt, BioModels, ChEMBLdb). Wrapping additional Web Services based either on Representational State Transfer or Simple Object Access Protocol/Web Services Description Language technologies is eased by the usage of object-oriented programming. BioServices releases and documentation are available at http://pypi.python.org/pypi/bioservices under a GPL-v3 license.

32 CFR 191.6 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... include Dr. Martin Luther King Jr.'s Birthday, Black History Month, National Women's History Week, Women's... Council on Accessible Technology in accordance with General Services Administration Order ADM 5420.71A...

KSC Headquarters Building Groundbreaking Ceremony

NASA Image and Video Library

2014-10-07

Groundbreaking for the new Central Campus will take place in the Industrial Area at NASA's Kennedy Space Center in Florida. A scale model of the new facility and landscaping is on display for the ceremony. Kennedy is transforming into a multi-user, 21st century spaceport supporting both commercial and government users and operations. Central Campus Phase I includes construction of a new Headquarters Building as one of the major components of the strategy. The new Headquarters Building will be a seven-story, 200,000-square-foot facility that will house about 500 NASA civil service and contractor employees.

KSC Headquarters Building Groundbreaking Ceremony

NASA Image and Video Library

2014-10-07

Groundbreaking for the new Central Campus will take place in the Industrial Area at NASA's Kennedy Space Center in Florida. Nancy Bray, director of Kennedy's Center Operations Directorate, is interviewed by members of the media during the groundbreaking ceremony. Kennedy is transforming into a multi-user, 21st century spaceport supporting both commercial and government users and operations. Central Campus Phase I includes construction of a new Headquarters Building as one of the major components of the strategy. The new Headquarters Building will be a seven-story, 200,000-square-foot facility that will house about 500 NASA civil service and contractor employees.

Planning, Designing, Building, and Moving a Large Volume Maternity Service to a New Labor and Birth Unit.

PubMed

Thompson, Heather; Legorreta, Kimberly; Maher, Mary Ann; Lavin, Melanie M

Our health system recognized the need to update facility space and associated technology for the labor and birth unit within our large volume perinatal service to improve the patient experience, and enhance safety, quality of care, and staff satisfaction. When an organization decides to invest $30 million dollars in a construction project such as a new labor and birth unit, many factors and considerations are involved. Financial support, planning, design, and construction phases of building a new unit are complex and therefore require strong interdisciplinary collaboration, leadership, and project management. The new labor and birth unit required nearly 3 years of planning, designing, and construction. Patient and family preferences were elicited through consumer focus groups. Multiple meetings with the administrative and nursing leadership teams, staff nurses, nurse midwives, and physicians were held to generate ideas for improvement in the new space. Involving frontline clinicians and childbearing women in the process was critical to success. The labor and birth unit moved to a new patient tower in a space that was doubled in square footage and geographically now on three separate floors. In the 6 months prior to the move, many efforts were made in our community to share our new space. The marketing strategy was very detailed and creative with ongoing input from the nursing leadership team. The nursing staff was involved in every step along the way. It was critical to have champions as workflow teams emerged. We hosted simulation drills and tested scenarios with new workflows. Move day was rehearsed with representatives of all members of the perinatal team participating. These efforts ultimately resulted in a move time of ~5 hours. Birth volumes increased 7% within the first 6 months. After 3 years in our new space, our birth volumes have risen nearly 15% and are still growing. Key processes and roles responsible for a successful build, efficient and safe move

11. Photocopy of Sheet 4 of Building Plan R453 (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of Sheet 4 of Building Plan R4-53 (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) SIDE ELEVATION AND FRAMING - Buffalo Guard Station, Residence, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

10. Photocopy of Sheet 2 of Building Plan R451, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of Sheet 2 of Building Plan R4-51, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) Framing and Foundation Plans. - Buffalo Guard Station, Office, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

A MODEL BUILDING CODE ARTICLE ON FALLOUT SHELTERS WITH RECOMMENDATIONS FOR INCLUSION OF REQUIREMENTS FOR FALLOUT SHELTER CONSTRUCTION IN FOUR NATIONAL MODEL BUILDING CODES.

ERIC Educational Resources Information Center

American Inst. of Architects, Washington, DC.

A MODEL BUILDING CODE FOR FALLOUT SHELTERS WAS DRAWN UP FOR INCLUSION IN FOUR NATIONAL MODEL BUILDING CODES. DISCUSSION IS GIVEN OF FALLOUT SHELTERS WITH RESPECT TO--(1) NUCLEAR RADIATION, (2) NATIONAL POLICIES, AND (3) COMMUNITY PLANNING. FALLOUT SHELTER REQUIREMENTS FOR SHIELDING, SPACE, VENTILATION, CONSTRUCTION, AND SERVICES SUCH AS ELECTRICAL…

SPGM Moves to Building 434 This Month | Poster

Cancer.gov

By Ashley DeVine, Staff Writer Scientific Publications, Graphics & Media (SPGM) moves to a new location this month—Building 434. The entrance is located on Wood Street. The move will take place between Monday, February 24, and Friday, February 28. During the move, SPGM will limit disruptions to service as much as possible. A sign in front of the building will direct you to the

Examining Strategies to Build and Sustain Healthy Aging Programming Collaboratives

ERIC Educational Resources Information Center

Altpeter, Mary; Schneider, Ellen Caylor; Whitelaw, Nancy

2014-01-01

Background: Community collaboratives provide a means to build local capacity, reduce service fragmentation and duplication, maximize efficiency, and create synergies for "systems change". But what are the collaborative practices that aging services providers and other stakeholders employ for "system change" and…

39. Perimeter acquisition radar building room #504, techinal maintenance and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. Perimeter acquisition radar building room #504, techinal maintenance and repair center (TMRC) and tactical support equipment (TSE) storage area; storage-travel wave tubes - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

26 CFR 1.42-7 - Substantially bond-financed buildings. [Reserved

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Substantially bond-financed buildings. [Reserved] 1.42-7 Section 1.42-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Credits Against Tax § 1.42-7 Substantially bond-financed buildings. [Reserved] ...

Service-Learning Pathologies and Prognoses

ERIC Educational Resources Information Center

Schwartzman, Roy

2007-01-01

This essay addresses how to cope with several potential barriers to implementing effective service-learning projects. The discussion builds on experiences of developing and refining service-learning in upper-division communication courses. Difficulties arise in three areas: the institutional and physical setting, student attitudes, and community…

40. Perimeter acquisition radar building room #510B, chemical, biological, and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Perimeter acquisition radar building room #510B, chemical, biological, and radiological (CBR) air filter room no. 1 - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

6. Photocopy of Sheet 3 of Building Plan R421, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photocopy of Sheet 3 of Building Plan R4-21, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings') FRAMING PLAN AND GARAGE DOOR DETAIL - Buffalo Guard Station, Garage, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

11. Photocopy of Sheet 3 of Building Plan R451, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of Sheet 3 of Building Plan R4-51, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) Construction Details and Floor Framing. - Buffalo Guard Station, Office, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

5. Photocopy of Sheet 2 of Building Plan R421, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Photocopy of Sheet 2 of Building Plan R4-21, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings') BACK SIDE ELEVATIONS AND CONSTRUCTION DETAILS - Buffalo Guard Station, Garage, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

Structure based comprehensive modelling, spatial fingerprints mapping and ADME screening of curcumin analogues as novel ALR2 inhibitors

PubMed Central

Verma, Sant Kumar

2017-01-01

Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic complications. The limited triumph in the drug development against ALR2 is mainly because of its close structural similarity with the other members of aldo-keto reductase (AKR) superfamily viz. ALR1, AKR1B10; and lipophilicity problem i.e. poor diffusion of synthetic aldose reductase inhibitors (ARIs) to target tissues. The literature evidenced that naturally occurring curcumin demonstrates relatively specific and non-competitive inhibition towards human recombinant ALR2 over ALR1 and AKR1B10; however β-diketone moiety of curcumin is a specific substrate for liver AKRs and accountable for it’s rapid in vivo metabolism. In the present study, structure based comprehensive modelling studies were used to map the pharmacophoric features/spatial fingerprints of curcumin analogues responsible for their ALR2 specificity along with potency on a data set of synthetic curcumin analogues and naturally occurring curcuminoids. The data set molecules were also screened for drug-likeness or ADME parameters, and the screening data strongly support that curcumin analogues could be proposed as a good drug candidate for the development of ALR2 inhibitors with improved pharmacokinetic profile compared to curcuminoids due to the absence of β-diketone moiety in their structural framework. PMID:28399135

Media Services: Program Evaluation.

ERIC Educational Resources Information Center

Richardson, Edwin W.

The program for school media services in the Des Moines Independent Community School District is a combination of individual building media center programs and the district support services for these PK-12 programs, and its purpose is to ensure that students and staff have access to and are effective users of information. The district or central…

15. Front security entrance to the perimeter acquisition radar building, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Front security entrance to the perimeter acquisition radar building, showing rotogates 1 and 2 and entrance door to security operations control center (SOCC), room #108 - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

19. Perimeter acquisition radar building room #105, sign reads: Three ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Perimeter acquisition radar building room #105, sign reads: Three 660-ton trane chillers, each chiller can supply enough cooling for approximately 250 average air-conditioned homes - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

View (southwest to northeast) of remote launch operations building, showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View (southwest to northeast) of remote launch operations building, showing diesel exhaust shaft on the left and intake shaft on the right. To the far right is the tunnel entrance - Stanley R. Mickelsen Safeguard Complex, Remote Launch Operations Buildings, Near Service Road exit from patrol Road, Nekoma, Cavalier County, ND

47 CFR 22.947 - Five year build-out period.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MOBILE SERVICES Cellular Radiotelephone Service § 22.947 Five year build-out period. Except for systems...-out period, the licensee of the first cellular system on each channel block in each market may enter...-out period begins on the date the initial authorization for the first cellular system is granted, and...

Building Brand Power

NASA Astrophysics Data System (ADS)

Lakshmi, S.; Muthumani, S., Dr.

2017-05-01

Brand power is established through brand awareness. It’s all about making consumers familiar about their products and services. Marketing strategies should make the customers extend the positive approach towards brand and continue through repeated purchases. There is a triple perspective approach to investigate the brand awareness in this research. The brand awareness and brand equity are studied and the relationship between those are analyzed. This also drills down about the brand performance and knowledge with awareness which tries to find out the brands value and utility among the public. Continuous improvement on package design, quality and buying experience will lead to customer loyalty and preference. Branding should happen though creative ads, eye catchers and special campaigns. Brand awareness is the extent to which consumers are familiar with their product or services. Power of a brand is resides in the minds of the customers. To build a strong brand, it is one of the great challenge for the marketers to ensure that customers have the right experiences with products and services and various marketing programs. So that tenderness, beliefs, perspective, perception and so on linked to the brand. If we are presenting the brand with no enthusiasm or spunk, people are going to forget about our brand. Even though that may seem harsh, it’s the naked truth in today’s marketing world. Brand must reach out to the community by special events, creating campaigns to keep the brand relevant also offer customer a unique experience. Here we study about the brand consciousness and to identify the cohesion between brand awareness with knowledge and performance and also to assess the effect of brand awareness on consumer purchase. In this study we necessary statistical tools like chi-square test ad t-test has been used to analyse the collected data. It is highly recommend to increase brand awareness, the marketers are constantly required to build brand awareness both

The Power of Service Learning

ERIC Educational Resources Information Center

Richardson, Scott

2006-01-01

When students use classroom skills to build a wheelchair ramp, or teach their peers CPR, or grow vegetables for a food bank, or create children's books for preschoolers, or research and share local history, or educate the community about healthy living, or build and maintain nature trails, they are engaged in service learning (and are called…

49 CFR 192.377 - Service lines: Copper.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Service lines: Copper. 192.377 Section 192.377 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... § 192.377 Service lines: Copper. Each copper service line installed within a building must be protected...

49 CFR 192.377 - Service lines: Copper.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Service lines: Copper. 192.377 Section 192.377 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... § 192.377 Service lines: Copper. Each copper service line installed within a building must be protected...

12. Photocopy of Sheet 5 of Building Plan R453 (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of Sheet 5 of Building Plan R4-53 (USDA, Forest Service Intermountain Region, Ogden. File 7300, 'Buildings'.) PLAN OF KITCHEN CABINETS AND CONSTRUCTION DETAILS - Buffalo Guard Station, Residence, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

9. Photocopy of Sheet 1 of Building Plan R451, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of Sheet 1 of Building Plan R4-51, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) Front, Rear, and Side Elevations and Floor Plan. - Buffalo Guard Station, Office, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

10. Photocopy of Sheet 1 of Building Plan R453 (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of Sheet 1 of Building Plan R4-53 (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) FRONT AND SIDE ELEVATIONS AND FLOOR PLAN - Buffalo Guard Station, Residence, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

4. Photocopy of Sheet 1 of Building Plan R421, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of Sheet 1 of Building Plan R4-21, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings') FRONT AND SIDE ELEVATIONS, FLOOR AND FOUNDATION PLANS. - Buffalo Guard Station, Garage, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

Building effective working relationships across culturally and ethnically diverse communities.

PubMed

Hosley, Cheryl A; Gensheimer, Linda; Yang, Mai

2003-01-01

Amherst H. Wilder Foundation's Social Adjustment Program for Southeast Asians is implementing two collaborative, best practice, mental health and substance abuse prevention service models in Minnesota. It faced several issues in effectively bridging multiple cultural groups, including building a diverse collaborative team, involving families and youth, reconciling cultural variation in meeting styles, and making best practice models culturally appropriate. Researchers and program staff used multiple strategies to address these challenges and build successful partnerships. Through shared goals, flexibility, and a willingness to explore and address challenges, collaboratives can promote stronger relationships across cultural communities and improve their service delivery systems.

Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE.

PubMed

Scala, Angela; Rescifina, Antonio; Micale, Nicola; Piperno, Anna; Schirmeister, Tanja; Maes, Louis; Grassi, Giovanni

2018-02-01

In an effort to identify novel molecular warheads able to inhibit Leishmania mexicana cysteine protease CPB2.8ΔCTE, fused benzo[b]thiophenes and β,β'-triketones emerged as covalent inhibitors binding the active site cysteine residue. Enzymatic screening showed a moderate-to-excellent activity (12%-90% inhibition of the target enzyme at 20 μm). The most promising compounds were selected for further profiling including in vitro cell-based assays and docking studies. Computational data suggest that benzo[b]thiophenes act immediately as non-covalent inhibitors and then as irreversible covalent inhibitors, whereas a reversible covalent mechanism emerged for the 1,3,3'-triketones with a Y-topology. Based on the predicted physicochemical and ADME-Tox properties, compound 2b has been identified as a new drug-like, non-mutagen, non-carcinogen, and non-neurotoxic lead candidate. © 2017 John Wiley & Sons A/S.

HOT CELL BUILDING, TRA632. CONTEXTUAL AERIAL VIEW OF HOT CELL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HOT CELL BUILDING, TRA-632. CONTEXTUAL AERIAL VIEW OF HOT CELL BUILDING, IN VIEW AT LEFT, AS YET WITHOUT ROOF. PLUG STORAGE BUILDING LIES BETWEEN IT AND THE SOUTH SIDE OF THE MTR BUILDING AND ITS WING. NOTE CONCRETE DRIVE BETWEEN ROLL-UP DOOR IN MTR BUILDING AND CHARGING FACE OF PLUG STORAGE. REACTOR SERVICES BUILDING (TRA-635) WILL COVER THIS DRIVE AND BUTT UP TO CHARGING FACE. DOTTED LINE IS ON ORIGINAL NEGATIVE. TRA PARKING LOT IN LEFT CORNER OF THE VIEW. CAMERA FACING NORTHWESTERLY. INL NEGATIVE NO. 8274. Unknown Photographer, 7/2/1953 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Reorienting health services in the Northern Territory of Australia: a conceptual model for building health promotion capacity in the workforce.

PubMed

Judd, Jenni; Keleher, Helen

2013-06-01

Reorienting work practices to include health promotion and prevention is complex and requires specific strategies and interventions. This paper presents original research that used 'real-world' practice to demonstrate that knowledge gathered from practice is relevant for the development of practice-based evidence. The paper shows how practitioners can inform and influence improvements in health promotion practice. Practitioner-informed evidence necessarily incorporates qualitative research to capture the richness of their reflective experiences. Using a participatory action research (PAR) approach, the research question asked 'what are the core dimensions of building health promotion capacity in a primary health care workforce in a real-world setting?' PAR is a method in which the researcher operates in full collaboration with members of the organisation being studied for the purposes of achieving some kind of change, in this case to increase the amount of health promotion and prevention practice within this community health setting. The PAR process involved six reflection and action cycles over two years. Data collection processes included: survey; in-depth interviews; a training intervention; observations of practice; workplace diaries; and two nominal groups. The listen/reflect/act process enabled lessons from practice to inform future capacity-building processes. This research strengthened and supported the development of health promotion to inform 'better health' practices through respectful change processes based on research, practitioner-informed evidence, and capacity-building strategies. A conceptual model for building health promotion capacity in the primary health care workforce was informed by the PAR processes and recognised the importance of the determinants approach. Practitioner-informed evidence is the missing link in the evidence debate and provides the links between evidence and its translation to practice. New models of health promotion service

Designing to Meet New Requirements of Differing Services.

ERIC Educational Resources Information Center

Mathers, Andrew S.

1982-01-01

Characterizing "older library buildings" as those built prior to 1960, this article discusses special problems and challenges for the librarian and architect renovator, including building codes and new requirements of differing services. (EJS)

76 FR 65511 - Office of Governmentwide Policy; Office of Federal High-Performance Green Buildings; the Green...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-21

... Governmentwide Policy; Office of Federal High- Performance Green Buildings; the Green Building Advisory Committee... meeting of the Green Building Advisory Committee Meeting (the Committee). The meeting is open to the..., Office of Federal High-Performance Green Buildings, Office of Governmentwide Policy, General Services...

Building the Child Wellbeing Project: Practitioners' Perspectives on the Role of Implementation Science in Strengthening Post-Care Child Welfare Services. Research-to-Results Brief. Publication #2012-18

ERIC Educational Resources Information Center

Wilson, Dawn; Brandes, Beth; Ball, Heather; Malm, Karin

2012-01-01

This is the third brief in a series: "Building a Post-Care Service System in Child Welfare: Lessons Learned from the Frontlines of Implementation Science in Catawba County." The first of the three briefs provided background information on the initiative that is the focus of the series--the Catawba County Child Wellbeing Project. Both…

Building spatial layout that supports healthier behavior of office workers: a new performance mandate for sustainable buildings.

PubMed

Hua, Ying; Yang, Eunhwa

2014-01-01

The pursuit of efficiency and the permeation of communication technologies in modern workplace have increased prolonged sitting and physical inactivity among the white-collar workforce. Physical inactivity is a major risk factor for developing various chronic diseases and obesity. This study intends to understand the impact of physical environment on both voluntary and imperative physical activity levels in an office building, and to collect evidence for design suggestions to encourage office workers' activity level on a daily basis. This study examined how proximity from individual workstations to various shared service and amenity spaces in the workplace (e.g., meeting spaces, copy areas, kitchens, restrooms, elevators, and stairs) is associated with office workers' physical activity level (e.g., sedentary and non-sedentary behavior) and their environmental and job satisfaction. To objectively measure physical activity, twenty-six office workers, in a three-story office building, wore accelerometers for three consecutive days at work. Environmental and job satisfaction of office workers was measured by a questionnaire. Proximity variables were measured using the floor plans of the subject building. Participants on average were sedentary for 80% of the time during the study. Proximity to several service and amenity areas was positively associated with step counts and job satisfaction.

A Model Assessing Relevant Factors in Building Minority Library Service.

ERIC Educational Resources Information Center

Bonin, Kenneth Roy

1983-01-01

Presents research design applicable to definition of minority library service needs for any minority language group in Canada, focusing on French-speaking population outside Quebec. Profiles of the target group's population, culture, needs, and library services are highlighted. Five sources are given. (EJS)

17. Perimeter acquisition radar building room #105, mechanical equipment room ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Perimeter acquisition radar building room #105, mechanical equipment room no. 1; sign reads: Heat exchangers (shell and tube type). Provide precise temperature control of water for cooling critical electronic equipment - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

33. Perimeter acquisition radar building room #320, perimeter acquisition radar ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. Perimeter acquisition radar building room #320, perimeter acquisition radar operations center (PAROC), contains the tactical command and control group equipment required to control the par site. Showing spacetrack monitor console - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

MTR BUILDING, TRA603. SOUTHEAST CORNER, EAST SIDE FACING TOWARD RIGHT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

MTR BUILDING, TRA-603. SOUTHEAST CORNER, EAST SIDE FACING TOWARD RIGHT OF VIEW. CAMERA FACING NORTHWEST. LIGHT-COLORED PROJECTION AT LEFT IS ENGINEERING SERVICES BUILDING, TRA-635. SMALL CONCRETE BLOCK BUILDING AT CENTER OF VIEW IS FAST CHOPPER DETECTOR HOUSE, TRA-665. INL NEGATIVE NO. HD46-43-3. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Build an Assistive Technology Toolkit

ERIC Educational Resources Information Center

Ahrens, Kelly

2011-01-01

Assistive technology (AT) by its very nature consists of a variety of personal and customized tools for multiple learning styles and physical challenges. The author not only encourages students, parents, and educators to advocate for AT services, she also wants them to go a step further and build their own AT toolkits that can instill independence…

Application of 6D Building Information Model (6D BIM) for Business-storage Building in Slovenia

NASA Astrophysics Data System (ADS)

Pučko, Zoran; Vincek, Dražen; Štrukelj, Andrej; Šuman, Nataša

2017-10-01

The aim of this paper is to present an application of 6D building information modelling (6D BIM) on a real business-storage building in Slovenia. First, features of building maintenance in general are described according to the current Slovenian legislation, and also a general principle of BIM is given. After that, step-by-step activities for modelling 6D BIM are exposed, namely from Element list for maintenance, determination of their lifetime and service measures, cost analysing and time analysing to 6D BIM modelling. The presented 6D BIM model is designed in a unique way in which cost analysis is performed as 5D BIM model with linked data to use BIM Construction Project Management Software (Vico Office), integrated with 3D BIM model, whereas time analysis as 4D BIM model is carried out as non-linked data with the help of Excel (without connection to 3D BIM model). The paper is intended to serve as a guide to the building owners to prepare 6D BIM and to provide an insight into the relevant dynamic information about intervals and costs for execution of maintenance works in the whole building lifecycle.

Outcomes of Acellular Dermal Matrix for Immediate Tissue Expander Reconstruction with Radiotherapy: A Retrospective Cohort Study.

PubMed

Craig, Elizabeth S; Clemens, Mark W; Koshy, John C; Wren, James; Hong, Zhang; Butler, Charles; Garvey, Patrick; Selber, Jesse; Kronowitz, Steven

2018-05-24

Despite increasing literature support for the use of acellular dermal matrix (ADM) in expander-based breast reconstruction, the effect of ADM on clinical outcomes in the presence of post-mastectomy radiation therapy (PMRT) has not been well described. To analyze the impact ADM plays on clinical outcomes on immediate tissue expander (ITE) reconstruction undergoing PMRT. We retrospectively reviewed patients who underwent ITE breast reconstruction from 2004 to 2014 at MD Anderson Cancer Center. Patients were categorized into four cohorts: ADM, ADM with PMRT, non-ADM, and non-ADM with PMRT. Outcomes and complications were compared between cohorts. Over ten years, 957 patients underwent ITE reconstruction (683 non-ADM, 113 non-ADM with PMRT, 486 ADM, and 88 ADM with PMRT) with 1,370 reconstructions. Overall complication rates for the ADM and non-ADM cohorts were 39.0 and 16.7%, respectively (p <0.001). Within both cohorts, mastectomy skin flap necrosis (MSFN) was the most common complication, followed by infection. ADM use was associated with a significantly higher rate of infections and seromas in both radiated and non-radiated groups; however, when comparing radiated cohorts, the incidence of explantation was significantly lower with the use of ADM. The decision to use ADM for expander-based breast reconstruction should be performed with caution, given higher overall rates of complications, including infections and seromas. There may, however, be a role for ADM in cases requiring PMRT, as the overall incidence of implant failure is lower than non-ADM cases.

Planning Alcoholism Services; Participant Workbook.

ERIC Educational Resources Information Center

National Inst. on Alcohol Abuse and Alcoholism (DHEW/PHS), Rockville, MD.

This workbook is designed to build or improve the basic planning skills needed by persons responsible for program planning in alcohol service agencies. An understanding of the generic planning process in the development or expansion of community alcoholism-realted services can be acquired through the use of this guide. The workbook attempts to…

Health in the service of state-building in fragile and conflict affected contexts: an additional challenge in the medical-humanitarian environment.

PubMed

Philips, Mit; Derderian, Katharine

2015-01-01

Global health policy and development aid trends also affect humanitarian health work. Reconstruction, rehabilitation and development initiatives start increasingly earlier after crisis, unleashing tensions between development and humanitarian paradigms. Recently, development aid shows specific interest in contexts affected by conflict and fragility, with increasing expectations for health interventions to demonstrate transformative potential, including towards more resilient health systems as a contribution to state-building agendas. Current drives towards state-building opportunities in health interventions is mainly based on political aspirations, with little conclusive evidence on linking state-building efforts to conflict prevention, neither on transformative effects of health systems support. Moreover, negative consequences are possible in such volatile environments. We explore how to anticipate, discuss and monitor potential negative effects of current state-building approaches on health interventions, including on humanitarian aid. Overriding health systems approaches might increase tension in fragile and conflict affected contexts, because at odds with goals typically associated with immediate emergency response to populations' needs. Especially in protracted crisis, quality and timeliness of humanitarian response can be compromised, with strain on impartiality, targeting the most vulnerable, prioritising direct health benefits and most effective strategies. State-building focus could shift health aid priorities away from sick people and disease. Precedence of state institutions support over immediate, effective health service delivery can reduce population level results. As consequence people might question health workers' intention to privilege health above political, ethnic or other alliances, altering health and humanitarian workers' perception. Particularly in conflict, neither health system nor state are impartial bystanders. In spite of scarce

Exploiting the Multi-Service Domain Protecting Interface

DTIC Science & Technology

2012-10-17

Linux OpenVPN and IPSec VLAN services subsystems. Essentially, MSDPI becomes the transport mechanism for these subsystems. For the RIB, LSP, and...includes those necessary files to build a complete LiveCD system For example, adding various configuration files: ifcfg-eth?, ifcfg-ib?, openvpn ...aka IP address), openvpn files, specific files in the etc/sysconfig directory. %prep %build %install rm -rf $RPM_BUILD_ROOT mkdir -p

15. Photocopy of Sheet 1 of Building Plan R41A, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of Sheet 1 of Building Plan R4-1A, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) FRONT ELEVATION AND FLOOR PLAN - Buffalo Guard Station, Residence, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

3. Photocopy of Sheet 1 of Building Plan R495D, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of Sheet 1 of Building Plan R4-95D, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) ELEVATION, FRAMING AND CONSTRUCTION DETAILS - Buffalo Guard Station, Pumphouse, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

MRP (materiel requirements planning) II education: a team-building experience.

PubMed

Iemmolo, G R

1994-05-01

Conestoga Wood Specialties, a leader in the woodworking industry, is constantly striving for continuous improvement in manufacturing and service. Recently, the company embarked on a major MRP II education effort that served as a framework for team building. This team building concept has carried over into other aspects related to the business, such as the formalization of the sales and operations planning meeting. At Conestoga Wood, it is recognized that successful team building is necessary to achieve and maintain world-class performance.

26 CFR 1.48-11 - Qualified rehabilitated building; expenditures incurred before January 1, 1982.

Code of Federal Regulations, 2010 CFR

2010-04-01

... construction, or the completion of new construction after a building has been placed in service. For purposes... building, or to new construction, is determined upon all the facts and circumstances. (ii) Substantial... addition, a building is enlarged to the extent of any construction outside the exterior faces of the...

26 CFR 1.48-11 - Qualified rehabilitated building; expenditures incurred before January 1, 1982.

Code of Federal Regulations, 2011 CFR

2011-04-01

... construction, or the completion of new construction after a building has been placed in service. For purposes... building, or to new construction, is determined upon all the facts and circumstances. (ii) Substantial... addition, a building is enlarged to the extent of any construction outside the exterior faces of the...

26 CFR 1.48-11 - Qualified rehabilitated building; expenditures incurred before January 1, 1982.

Code of Federal Regulations, 2014 CFR

2014-04-01

... construction, or the completion of new construction after a building has been placed in service. For purposes... building, or to new construction, is determined upon all the facts and circumstances. (ii) Substantial... addition, a building is enlarged to the extent of any construction outside the exterior faces of the...

26 CFR 1.48-11 - Qualified rehabilitated building; expenditures incurred before January 1, 1982.

Code of Federal Regulations, 2012 CFR

2012-04-01

... construction, or the completion of new construction after a building has been placed in service. For purposes... building, or to new construction, is determined upon all the facts and circumstances. (ii) Substantial... addition, a building is enlarged to the extent of any construction outside the exterior faces of the...

26 CFR 1.48-11 - Qualified rehabilitated building; expenditures incurred before January 1, 1982.

Code of Federal Regulations, 2013 CFR

2013-04-01

... construction, or the completion of new construction after a building has been placed in service. For purposes... building, or to new construction, is determined upon all the facts and circumstances. (ii) Substantial... addition, a building is enlarged to the extent of any construction outside the exterior faces of the...

Reliability Engineering for Service Oriented Architectures

DTIC Science & Technology

2013-02-01

Common Object Request Broker Architecture Ecosystem In software , an ecosystem is a set of applications and/or services that grad- ually build up over time...Enterprise Service Bus Foreign In an SOA context: Any SOA, service or software which the owners of the calling software do not have control of, either...SOA Service Oriented Architecture SRE Software Reliability Engineering System Mode Many systems exhibit different modes of operation. E.g. the cockpit

PBF Reactor Building (PER620). Plot plan shows layout, including auxiliary ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PBF Reactor Building (PER-620). Plot plan shows layout, including auxiliary buildings: Emergency Generator (621), Hose House (622), Cooling Tower Auxiliary (624), Maintenance and Storage Warehouse (625), Gas Cylinder Storage (627), Hose House (628), Cooling Tower (720), Substation (719), and other features. Road connections between PBF Reactor, its control building, and SPERT-I site. Note cable trenches along road to control building. Date: July 1965. Ebasco Services, PER-U-101. INEEL index no. 761-0100-00-205-123005 - Idaho National Engineering Laboratory, SPERT-I & Power Burst Facility Area, Scoville, Butte County, ID

Alabama Public Library Service Annual Report, 1995.

ERIC Educational Resources Information Center

Alabama Public Library Service, Montgomery.

This annual report summarizes activities of the Alabama Public Library Service (APLS) for the fiscal year 1995. The APLS is charged with improving library services throughout the state to ensure that all citizens have access to quality library and information services. During fiscal year 1995, major building renovations were completed with the…

FAST CHOPPER BUILDING, TRA665. CAMERA FACING NORTH. NOTE BRICKEDIN WINDOW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FAST CHOPPER BUILDING, TRA-665. CAMERA FACING NORTH. NOTE BRICKED-IN WINDOW ON RIGHT SIDE (BELOW PAINTED NUMERALS "665"). SLIDING METAL DOOR ON COVERED RAIL AT UPPER LEVEL. SHELTERED ENTRANCE TO STEEL SHIELDING DOOR. DOOR INTO MTR SERVICE BUILDING, TRA-635, STANDS OPEN. MTR BEHIND CHOPPER BUILDING. INL NEGATIVE NO. HD42-1. Mike Crane, Photographer, 3/2004 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Health service resilience in Yobe state, Nigeria in the context of the Boko Haram insurgency: a systems dynamics analysis using group model building.

PubMed

Ager, Alastair K; Lembani, Martina; Mohammed, Abdulaziz; Mohammed Ashir, Garba; Abdulwahab, Ahmad; de Pinho, Helen; Delobelle, Peter; Zarowsky, Christina

2015-01-01

Yobe State has faced severe disruption of its health service as a result of the Boko Haram insurgency. A systems dynamics analysis was conducted to identify key pathways of threat to provision and emerging pathways of response and adaptation. Structured interviews were conducted with 39 stakeholders from three local government areas selected to represent the diversity of conflict experience across the state: Damaturu, Fune and Nguru, and with four officers of the PRRINN-MNCH program providing technical assistance for primary care development in the state. A group model building session was convened with 11 senior stakeholders, which used participatory scripts to review thematic analysis of interviews and develop a preliminary systems model linking identified variables. Population migration and transport restrictions have substantially impacted access to health provision. The human resource for health capability of the state has been severely diminished through the outward migration of (especially non-indigenous) health workers and the suspension of programmes providing external technical assistance. The political will of the Yobe State government to strengthen health provision - through lifting a moratorium on recruitment and providing incentives for retention and support of staff - has supported a recovery of health systems functioning. Policies of free-drug provision and decentralized drug supply appear to have been protective of the operation of the health system. Community resources and cohesion have been significant assets in combatting the impacts of the insurgency on service utilization and quality. Staff commitment and motivation - particularly amongst staff indigenous to the state - has protected health care quality and enabled flexibility of human resource deployment. A systems analysis using participatory group model building provided a mechanism to identify key pathways of threat and adaptation with regard to health service functioning. Generalizable

A Platform Architecture for Sensor Data Processing and Verification in Buildings

ERIC Educational Resources Information Center

Ortiz, Jorge Jose

2013-01-01

This thesis examines the state of the art of building information systems and evaluates their architecture in the context of emerging technologies and applications for deep analysis of the built environment. We observe that modern building information systems are difficult to extend, do not provide general services for application development, do…

City of San Antonio, Texas Better Buildings Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyer, Liza C.; Hammer, Mary C.

2014-06-30

The San Antonio Better Buildings Program is a unified single-point-of-service energy efficiency delivery mechanism targeting residential, commercial, institutional, industrial and public buildings. This comprehensive and replicable energy efficiency program is designed to be an effective demand side management initiative to provide a seamless process for program participants to have turn-key access to expert analysis, support and incentives to improve the performance of their in-place energy using systems, while reducing electrical energy use and demand.

The African Field Epidemiology Network-Networking for effective field epidemiology capacity building and service delivery

PubMed Central

Gitta, Sheba Nakacubo; Mukanga, David; Babirye, Rebecca; Dahlke, Melissa; Tshimanga, Mufuta; Nsubuga, Peter

2011-01-01

Networks are a catalyst for promoting common goals and objectives of their membership. Public Health networks in Africa are crucial, because of the severe resource limitations that nations face in dealing with priority public health problems. For a long time, networks have existed on the continent and globally, but many of these are disease-specific with a narrow scope. The African Field Epidemiology Network (AFENET) is a public health network established in 2005 as a non-profit networking alliance of Field Epidemiology and Laboratory Training Programs (FELTPs) and Field Epidemiology Training Programs (FETPs) in Africa. AFENET is dedicated to helping ministries of health in Africa build strong, effective and sustainable programs and capacity to improve public health systems by partnering with global public health experts. The Network's goal is to strengthen field epidemiology and public health laboratory capacity to contribute effectively to addressing epidemics and other major public health problems in Africa. AFENET currently networks 12 FELTPs and FETPs in sub-Saharan Africa with operations in 20 countries. AFENET has a unique tripartite working relationship with government technocrats from human health and animal sectors, academicians from partner universities, and development partners, presenting the Network with a distinct vantage point. Through the Network, African nations are making strides in strengthening their health systems. Members are able to: leverage resources to support field epidemiology and public health laboratory training and service delivery notably in the area of outbreak investigation and response as well as disease surveillance; by-pass government bureaucracies that often hinder and frustrate development partners; and consolidate efforts of different partners channelled through the FELTPs by networking graduates through alumni associations and calling on them to offer technical support in various public health capacities as the need arises

16. Photocopy of Sheet 4 of Building Plan R41A, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photocopy of Sheet 4 of Building Plan R4-1A, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) SIDE ELEVATION AND DINING ALCOVE PLAN - Buffalo Guard Station, Residence, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

Building Trust-Based Sustainable Networks

DTIC Science & Technology

2013-06-05

entities to build sustainable networks with limited resources or misbehaving entities by learning from the lessons in the social sciences. We discuss...their individuality); and ■ Misbehaving nodes in terms of environmental, economic, and social perspectives. The sustainable network concerns...equitable access to particular services which are otherwise abused by misbehaving or malicious users. Such approaches provide a fair and

Cool Apps: Building Cryospheric Data Applications with Standards-Based Service Oriented Architecture

NASA Astrophysics Data System (ADS)

Oldenburg, J.; Truslove, I.; Collins, J. A.; Liu, M.; Lewis, S.; Brodzik, M.

2012-12-01

The National Snow and Ice Data Center (NSIDC) holds a large collection of cryospheric data, and is involved in a number of informatics research and development projects aimed at improving the discoverability and accessibility of these data. To develop high- quality software in a timely manner, we have adopted a Service- Oriented Architecture (SOA) approach for our core technical infrastructure development. Data services at NSIDC are internally exposed to other tools and applications through standards-based service interfaces. These standards include OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting), various OGC (Open Geospatial Consortium) standards including WMS (Web Map Service) and WFS (Web Feature Service), ESIP (Federation of Earth Sciences Information Partners) OpenSearch, and NSIDC-defined service endpoints which follow a RESTful architecture. By taking a standards-based approach, we are able to use off-the-shelf tools and libraries to consume, translate and broker these data services, and thus develop applications faster. Additionally, by exposing public interfaces to these services we provide valuable data services to technical collaborators; for example, NASA Reverb (http://reverb.echo.nasa.gov) uses NSIDC's WMS services. Our latest generation of web applications consume these data services directly. The most complete example of this is the Operation IceBridge Data Portal (http://nsidc.org/icebridge/ portal) which depends on many of the aforementioned services, retrieving data in several ways. The maps it displays are obtained through the use of WMS and WFS protocols from a MapServer instance hosted at NSIDC. Links to the scientific data collected on Operation IceBridge campaigns are obtained through ESIP OpenSearch requests service providers that encapsulate our metadata databases. These standards-based web services are also developed at NSIDC and are designed to be used independently of the Portal. This poster provides a visual

The Ties that Bind: Creating Great Customer Service.

ERIC Educational Resources Information Center

Lisker, Peter

2000-01-01

Offers suggestions for libraries on how to develop a customer service plan to provide excellent service, create a positive environment for staff members, foster new and continued positive relationships with patrons, and evaluate customer service goals and objectives. Also discusses policies and building appearance. (Author/LRW)

42. Perimeter acquisition radar building plaque, commemorating parransferral from U.S. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Perimeter acquisition radar building plaque, commemorating parransferral from U.S. Army ballistic missile defense organization to U.S. Air Force aerospace defense command (dated 1 October 1977) - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

41 CFR 102-74.20 - What are occupancy services?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What are occupancy services? 102-74.20 Section 102-74.20 Public Contracts and Property Management Federal Property Management... Management Occupancy Services § 102-74.20 What are occupancy services? Occupancy services are— (a) Building...

41 CFR 102-74.20 - What are occupancy services?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are occupancy services? 102-74.20 Section 102-74.20 Public Contracts and Property Management Federal Property Management... Management Occupancy Services § 102-74.20 What are occupancy services? Occupancy services are— (a) Building...

16. Perimeter acquisition radar building room #102, electrical equipment room; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Perimeter acquisition radar building room #102, electrical equipment room; the prime power distribution system. Excellent example of endulum-types shock isolation. The grey cabinet and barrel assemble is part of the polychlorinated biphenyl (PCB) retrofill project - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

18. Perimeter acquisition radar building room #105, deionizers (filter tanks) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Perimeter acquisition radar building room #105, deionizers (filter tanks) for data processor cooling and ice backup; sign reads: Deionizer units provide high-purity water by removal of oxygen, and organic and mineral content from water - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

Facility Focus: Food Service.

ERIC Educational Resources Information Center

College Planning & Management, 2002

2002-01-01

Describes the Hawthorn Court Community Center at Iowa State University, Ames, and the HUB-Robeson Center at Pennsylvania State University. Focuses on the food service offered in these new student-life buildings. Includes photographs. (EV)

R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments.

PubMed

Vanquelef, Enguerran; Simon, Sabrina; Marquant, Gaelle; Garcia, Elodie; Klimerak, Geoffroy; Delepine, Jean Charles; Cieplak, Piotr; Dupradeau, François-Yves

2011-07-01

R.E.D. Server is a unique, open web service, designed to derive non-polarizable RESP and ESP charges and to build force field libraries for new molecules/molecular fragments. It provides to computational biologists the means to derive rigorously molecular electrostatic potential-based charges embedded in force field libraries that are ready to be used in force field development, charge validation and molecular dynamics simulations. R.E.D. Server interfaces quantum mechanics programs, the RESP program and the latest version of the R.E.D. tools. A two step approach has been developed. The first one consists of preparing P2N file(s) to rigorously define key elements such as atom names, topology and chemical equivalencing needed when building a force field library. Then, P2N files are used to derive RESP or ESP charges embedded in force field libraries in the Tripos mol2 format. In complex cases an entire set of force field libraries or force field topology database is generated. Other features developed in R.E.D. Server include help services, a demonstration, tutorials, frequently asked questions, Jmol-based tools useful to construct PDB input files and parse R.E.D. Server outputs as well as a graphical queuing system allowing any user to check the status of R.E.D. Server jobs.

Research of GIS-services applicability for solution of spatial analysis tasks.

NASA Astrophysics Data System (ADS)

Terekhin, D. A.; Botygin, I. A.; Sherstneva, A. I.; Sherstnev, V. S.

2017-01-01

Experiments for working out the areas of applying various gis-services in the tasks of spatial analysis are discussed in this paper. Google Maps, Yandex Maps, Microsoft SQL Server are used as services of spatial analysis. All services have shown a comparable speed of analyzing the spatial data when carrying out elemental spatial requests (building up the buffer zone of a point object) as well as the preferences of Microsoft SQL Server in operating with more complicated spatial requests. When building up elemental spatial requests, internet-services show higher efficiency due to cliental data handling with JavaScript-subprograms. A weak point of public internet-services is an impossibility to handle data on a server side and a barren variety of spatial analysis functions. Microsoft SQL Server offers a large variety of functions needed for spatial analysis on the server side. The authors conclude that when solving practical problems, the capabilities of internet-services used in building up routes and completing other functions with spatial analysis with Microsoft SQL Server should be involved.

PRACTICAL EXPERIENCES WITH TECHNOLOGIES FOR DECONTAMINATION OF B. ANTHRACIS IN LARGE BUILDINGS.

EPA Science Inventory

In the Fall of 2001 a number of buildings were contaminated with B. anthracis (B.A.) from letters processed through United States Postal Service and other mail handling facilities. All of the buildings have now been decontaminated using a variety of technologies. In a number of...

17. Photocopy of Sheet 5 of Building Plan R41A, (USDA, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of Sheet 5 of Building Plan R4-1A, (USDA, Forest Service, Intermountain Region, Ogden. File 7300, 'Buildings'.) FRAMING PLAN, KITCHEN CABINET PLAN AND BATHTUB ARCH PLAN - Buffalo Guard Station, Residence, U.S. Highway 20/191 at Buffalo River, Island Park, Fremont County, ID

50 CFR 260.99 - Buildings and structures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Buildings and structures. 260.99 Section 260.99 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE PROCESSED FISHERY PRODUCTS, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER...

50 CFR 260.99 - Buildings and structures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Buildings and structures. 260.99 Section 260.99 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE PROCESSED FISHERY PRODUCTS, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER...

50 CFR 260.99 - Buildings and structures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Buildings and structures. 260.99 Section 260.99 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE PROCESSED FISHERY PRODUCTS, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER...

50 CFR 260.99 - Buildings and structures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Buildings and structures. 260.99 Section 260.99 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE PROCESSED FISHERY PRODUCTS, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER...

The effect of Employee Assistance Programs use on healthcare utilization.

PubMed

Zarkin, G A; Bray, J W; Qi, J

2000-04-01

To estimate the effect of Employee Assistance Program (EAP) use on healthcare utilization as measured by health claims. A unique data set that combines individual-level information on EAP utilization, demographic information, and health insurance claims from 1991 to 1995 for all employees of a large midwestern employer. Using "fixed-effect" econometric models that control for unobserved differences between individuals' propensities to use healthcare resources and the EAP, we perform our analyses in two steps. First, for those employees who visited the EAP, we test whether post-EAP claims differ from pre-EAP claims. Second, we combine claims data of individuals who went to an EAP with those of individuals who did not use an EAP to test whether differences in utilization exist between EAP users and nonusers. From the EAP we obtained the date of first EAP contact for all employees who used the service, and from the company's human resources department we obtained limited demographic data on all employees. We obtained healthcare utilization claims data on all employees and their dependents from the company's two healthcare plans: a fee-for-service (FFS) plan and a health maintenance organization (HMO) plan. We found that going to an EAP substantially increases both the probability of an alcohol, drug abuse, or mental health (ADM) claim and the number of ADM claims in the same quarter as EAP contact. The increased probability of an ADM claim persists for approximately 11 quarters after the initial contact, while the increased ADM charges persist for approximately six quarters after the initial EAP contact. Our results strongly suggest that the EAP is able to identify behavioral and other health problems that may affect workplace performance and prompt EAP users to access ADM and other healthcare. Consistent with the stated goals of many EAPs, including the one examined in this study, this process should improve individuals' health, family functioning, and workplace