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Sample records for administered kava kava

  1. Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans

    PubMed Central

    Gurley, Bill J.; Swain, Ashley; Barone, Gary W.; Williams, D. Keith; Breen, Philip; Yates, C. Ryan; Stuart, Leslie B.; Hubbard, Martha A.; Tong, Yudong; Cheboyina, Sreekhar

    2007-01-01

    Phytochemical-mediated modulation of p-glycoprotein (P-gp) and other drug transporters may give rise to many herb-drug interactions. Serial plasma concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with goldenseal or kava kava modified P-gp activity in vivo. Twenty healthy volunteers were randomly assigned to receive a standardized goldenseal (3210 mg daily) or kava kava (1227 mg daily) supplement for 14 days, followed by a 30-day washout period. Subjects were also randomized to receive rifampin (600 mg daily, 7 days) and clarithromycin (1000 mg daily, 7 days) as positive controls for P-gp induction and inhibition, respectively. Digoxin (Lanoxin®, 0.5 mg) was administered orally before and at the end of each supplementation and control period. Serial digoxin plasma concentrations were obtained over 24 hours and analyzed by chemiluminescent immunoassay. Comparisons of AUC(0–3), AUC(0–24), Cmax,, CL/F, and elimination half-life were used to assess the effects of goldenseal, kava kava, rifampin, and clarithromycin on digoxin pharmacokinetics. Rifampin produced significant reductions (p<0.01) in AUC(0–3), AUC(0–24), CL/F, T1/2, and Cmax, while clarithromycin increased these parameters significantly (p<0.01). With the exception of goldenseal’s effect on Cmax (14% increase), no statistically significant effects on digoxin pharmacokinetics were observed following supplementation with either goldenseal or kava kava. When compared to rifampin and clarithromycin, supplementation with these specific formulations of goldenseal or kava kava did not appear to affect digoxin pharmacokinetics, suggesting that these supplements are not potent modulators of P-gp in vivo. PMID:16221754

  2. KaVA ESTEMA project

    NASA Astrophysics Data System (ADS)

    Oyadomari, Miyako; Imai, Hiroshi; Cho, Se-Hyung; Asaki, Yoshiharu; Choi, Yoon-Kyong; Kim, Jaeheon; Yun, Youngjoo; Matsumoto, Naoko; Min, Cheul-Hong; Oyama, Tomoaki; Yoon, Sung-Chul; Yoon, Dong-Hwan; Kim, Dong-Jin; Dodson, Richard; Rioja, Maria; Burns, Ross; Orosz, Gabor; Nakagawa, Akiharu; Chibueze O, James; Nakashima, Jun-ichi; Sobolev, Andrey

    2016-07-01

    The ESTEMA (Expanded Study on Stellar Masers) project is one of three Large Programs of the KaVA (the combined array of the Korean VLBI Network and Japanese VLBI Exploration of Radio Astrometry), and conducted in 2015-2016. It aims to publish a database of the largest sample of VLBI images of circumstellar water (H2O) and silicon-monoxide (SiO) maser sources towards circumstellar envelopes (CSEs) of 80 evolved stars in late AGB to early post-AGB phase. Here we present the specifications of the ESTEMA observations and the planned scientific goals in order to share the basic information of the ESTEMA with astronomical community and encourage future collaborations with the ESTEMA and future follow-up observations for the targeted stars.

  3. The Health Effects of Kava/Sakau and Betel Nut.

    ERIC Educational Resources Information Center

    Lee, Harvey

    For generations Pacific Islanders have used kava root and betel nut for a variety of cultural, medicinal, and ceremonial purposes: to overcome social barriers and lubricate social interactions; to cure bodily afflictions; and to accompany traditional and religious rituals. Kava, also known as ava, sakau, and yaqona has a long tradition as a…

  4. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum).

    PubMed

    Xuan, T D; Elzaawely, A A; Fukuta, M; Tawata, S

    2006-02-01

    This is the first report showing that kava lactones are plant and plant fungus growth inhibitors. Aqueous extract of kava roots showed high allelopathic potential and strongly suppressed germination and growth of lettuce, radish, barnyardgrass, and monochoria. Nine kava lactones were detected using GC-MS including desmethoxyyagonin, kavain, 7,8-dihydrokavain, hydroxykavain, yagonin, 5,6,7,8-tetrahydroxyyagonin, methysticin, dihydromethysticin, and 11-hydroxy-12-methoxydihydrokavain. Quantities of desmethoxyyagonin, kavain, 7,8-dihydrokavain, yagonin, methysticin, and dihydromethysticin detected were 4.3, 6.9, 18.6, 5.7, 1.4, and 5.4 mg/g of dry weight, respectively. These six major lactones in kava roots showed great herbicidal and antifungal activities. Growth of lettuce and barnyardgrass were significantly inhibited at 1-10 ppm, and four plant fungi including Colletotrichum gloeosporides, Fusarium solani, Fusarium oxysporum, and Trichoderma viride were significantly inhibited at 10-50 ppm. The biological activities of kava lactones were characterized by different double-bond linkage patterns in positions 5,6 and 7,8. The findings of this study suggest that kava lactones may be useful for the development of bioactive herbicides and fungicides.

  5. Driving following Kava Use and Road Traffic Injuries: A Population-Based Case-Control Study in Fiji (TRIP 14)

    PubMed Central

    Wainiqolo, Iris; Kafoa, Berlin; Kool, Bridget; Robinson, Elizabeth; Herman, Josephine; McCaig, Eddie; Ameratunga, Shanthi

    2016-01-01

    Objective To investigate the association between kava use and the risk of four-wheeled motor vehicle crashes in Fiji. Kava is a traditional beverage commonly consumed in many Pacific Island Countries. Herbal anxiolytics containing smaller doses of kava are more widely available. Methods Data for this population-based case-control study were collected from drivers of ‘case’ vehicles involved in serious injury-involved crashes (where at least one road user was killed or admitted to hospital for 12 hours or more) and ‘control’ vehicles representative of ‘driving time’ in the study base. Structured interviewer administered questionnaires collected self-reported participant data on demographic characteristics and a range of risk factors including kava use and potential confounders. Unconditional logistic regression models estimated odds ratios relating to the association between kava use and injury-involved crash risk. Findings Overall, 23% and 4% of drivers of case and control vehicles, respectively, reported consuming kava in the 12 hours prior to the crash or road survey. After controlling for assessed confounders, driving following kava use was associated with a four-fold increase in the odds of crash involvement (Odds ratio: 4.70; 95% CI: 1.90–11.63). The related population attributable risk was 18.37% (95% CI: 13.77–22.72). Acknowledging limited statistical power, we did not find a significant interaction in this association with concurrent alcohol use. Conclusion In this study conducted in a setting where recreational kava consumption is common, driving following the use of kava was associated with a significant excess of serious-injury involved road crashes. The precautionary principle would suggest road safety strategies should explicitly recommend avoiding driving following kava use, particularly in communities where recreational use is common. PMID:26930404

  6. Measuring the Chemical and Cytotoxic Variability of Commercially Available Kava (Piper methysticum G. Forster)

    PubMed Central

    Martin, Amanda C.; Johnston, Ed; Xing, Chengguo; Hegeman, Adrian D.

    2014-01-01

    Formerly used world-wide as a popular botanical medicine to reduce anxiety, reports of hepatotoxicity linked to consuming kava extracts in the late 1990s have resulted in global restrictions on kava use and have hindered kava-related research. Despite its presence on the United States Food and Drug Administration consumer advisory list for the past decade, export data from kava producing countries implies that US kava imports, which are not publicly reported, are both increasing and of a fairly high volume. We have measured the variability in extract chemical composition and cytotoxicity towards human lung adenocarcinoma A549 cancer cells of 25 commercially available kava products. Results reveal a high level of variation in chemical content and cytotoxicity of currently available kava products. As public interest and use of kava products continues to increase in the United States, efforts to characterize products and expedite research of this potentially useful botanical medicine are necessary. PMID:25365244

  7. Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.

    PubMed

    Pantano, Flaminia; Tittarelli, Roberta; Mannocchi, Giulio; Zaami, Simona; Ricci, Serafino; Giorgetti, Raffaele; Terranova, Daniela; Busardò, Francesco P; Marinelli, Enrico

    2016-01-01

    The 3Ks (kava, kratom and khat) are herbals that can potentially induce liver injuries. On the one hand, growing controversial data have been reported about the hepatotoxicity of kratom, while, on the other hand, even though kava and khat hepatotoxicity has been investigated, the hepatotoxic effects are still not clear. Chronic recreational use of kratom has been associated with rare instances of acute liver injury. Several studies and case reports have suggested that khat is hepatotoxic, leading to deranged liver enzymes and also histopathological evidence of acute hepatocellular degeneration. Numerous reports of severe hepatotoxicity potentially induced by kava have also been highlighted, both in the USA and Europe. The aim of this review is to focus on the different patterns and the mechanisms of hepatotoxicity induced by "the 3Ks", while trying to clarify the numerous aspects that still need to be addressed. PMID:27092496

  8. Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.

    PubMed

    Pantano, Flaminia; Tittarelli, Roberta; Mannocchi, Giulio; Zaami, Simona; Ricci, Serafino; Giorgetti, Raffaele; Terranova, Daniela; Busardò, Francesco P; Marinelli, Enrico

    2016-01-01

    The 3Ks (kava, kratom and khat) are herbals that can potentially induce liver injuries. On the one hand, growing controversial data have been reported about the hepatotoxicity of kratom, while, on the other hand, even though kava and khat hepatotoxicity has been investigated, the hepatotoxic effects are still not clear. Chronic recreational use of kratom has been associated with rare instances of acute liver injury. Several studies and case reports have suggested that khat is hepatotoxic, leading to deranged liver enzymes and also histopathological evidence of acute hepatocellular degeneration. Numerous reports of severe hepatotoxicity potentially induced by kava have also been highlighted, both in the USA and Europe. The aim of this review is to focus on the different patterns and the mechanisms of hepatotoxicity induced by "the 3Ks", while trying to clarify the numerous aspects that still need to be addressed.

  9. Kava, the anxiolytic herb: back to basics to prevent liver injury?

    PubMed Central

    Teschke, Rolf; Sarris, Jerome; Glass, Xaver; Schulze, Johannes

    2011-01-01

    The use of the anxiolytic herb kava has caused toxic liver injury in Western countries and economic problems in South Pacific Islands due to tthe regulatory ban on kava. This analysis shows poor quality of kava raw material as a cause for its toxicity and suggests preventative measures by going back to the traditional use of kava for the sake of the patients and the South Pacific economy. PMID:21284704

  10. Kava feeding in rats does not cause liver injury nor enhance galactosamine-induced hepatitis.

    PubMed

    DiSilvestro, Robert A; Zhang, Wenyi; DiSilvestro, David J

    2007-07-01

    Kava, like a number of herbals, has been associated with causing liver damage based on limited evidence. In contrast, the present study found that in rats, 3 mo feedings of two types of kava extracts (an acetone extract and an ethanol extract of the Samoan kava cultivar Ava Laau) at three different doses (31.25, 62.5 and 133 mg/kg diet) produced no liver injury based on serum markers of liver damage (sorbitol dehydrogenase activities, bile acid concentrations, and beta-glucuronidase activities) and serum lipid peroxide readings. In fact, for some measurements and some kava doses, the injury marker readings were below control values. Moreover, for these same parameters, kava feeding did not enhance the effects of the hepatotoxin galacatosamine (500 mg/kg ip); some kava doses even showed modest protection against liver injury. Liver histology analysis showed no signs of kava causing or enhancing liver injury. Thus, this study does not support the concept that kava produces or aggravates liver injury.

  11. Kava use, dyslipidaemia and biomarkers of dietary quality in Aboriginal people in Arnhem Land in the Northern Territory (NT), Australia.

    PubMed

    Clough, A R; Rowley, K; O'Dea, K

    2004-07-01

    Heavy kava use has been associated with sudden death in Aboriginal Australians in Arnhem Land (Northern Territory, Australia) where poor diets and a high incidence of premature coronary heart disease are known. Heavy kava users may suffer additional risk if further malnourished. Among 98 people (62 males, 36 females) in one community, 36 never used kava, 26 were past users, and 36 were continuing users. Across kava-using groups skinfold thickness, body mass index and body fat decreased. Total- and LDL-cholesterol were elevated in kava users compared to both former users and never users. HDL-cholesterol was higher in current users vs never users. Across kava-using groups, triglycerides, homocysteine and diet-derived antioxidant vitamins alpha-tocopherol and retinol, did not vary. Plasma carotenoid levels (indicative of vegetable and fruit intake) were very low, but when adjusted for plasma cholesterol, did not vary between kava-using groups. An obsession for kava drinking may mediate kava's direct effects on nutritional status.

  12. Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate?

    PubMed

    Teschke, Rolf; Wolff, Albrecht

    2011-02-01

    Since 1998 liver injury has been assumed in some patients after the use of kava (Piper methysticum G. Forster) as an anxyolytic herbal extract, but the regulatory causality evaluation of these cases was a matter of international and scientific debate. This review critically analyzes the regulatory issues of causality assessments of patients with primarily suspected kava hepatotoxicity and suggests recommendations for minimizing regulatory risks when assessing causality in these and other related cases. The various regulatory causality approaches were based on liver unspecific assessments such as ad hoc evaluations, the WHO scale using the definitions of the WHO Collaborating Centre for International Drug Monitoring, and the Naranjo scale. Due to their liver unspecificity, however, these causality approaches are not suitable for assessing cases of primarily assumed liver related adverse reactions by drugs and herbs including kava. Major problems emerged trough the combination of regulatory inappropriate causality assessment methods with the poor data quality as presented by the regulatory agency when reassessment was done and the resulting data were heavily criticized worldwide within the scientific community. Conversely, causality of cases with primarily assumed kava hepatotoxicity is best assessed by structured, quantitative and liver specific causality algorithms such as the scale of the CIOMS (Council for International Organizations of Medical Sciences) or the main-test as its update. Future strategies should therefore focus on the implementation of structured, quantitative and liver specific causality assessment methods as regulatory standards to improve regulatory causality assessments for liver injury by drugs and herbs including kava.

  13. Hepatotoxicity Induced by “the 3Ks”: Kava, Kratom and Khat

    PubMed Central

    Pantano, Flaminia; Tittarelli, Roberta; Mannocchi, Giulio; Zaami, Simona; Ricci, Serafino; Giorgetti, Raffaele; Terranova, Daniela; Busardò, Francesco P.; Marinelli, Enrico

    2016-01-01

    The 3Ks (kava, kratom and khat) are herbals that can potentially induce liver injuries. On the one hand, growing controversial data have been reported about the hepatotoxicity of kratom, while, on the other hand, even though kava and khat hepatotoxicity has been investigated, the hepatotoxic effects are still not clear. Chronic recreational use of kratom has been associated with rare instances of acute liver injury. Several studies and case reports have suggested that khat is hepatotoxic, leading to deranged liver enzymes and also histopathological evidence of acute hepatocellular degeneration. Numerous reports of severe hepatotoxicity potentially induced by kava have also been highlighted, both in the USA and Europe. The aim of this review is to focus on the different patterns and the mechanisms of hepatotoxicity induced by “the 3Ks”, while trying to clarify the numerous aspects that still need to be addressed. PMID:27092496

  14. Kava for the treatment of generalized anxiety disorder RCT: analysis of adverse reactions, liver function, addiction, and sexual effects.

    PubMed

    Sarris, J; Stough, C; Teschke, R; Wahid, Z T; Bousman, C A; Murray, G; Savage, K M; Mouatt, P; Ng, C; Schweitzer, I

    2013-11-01

    Presently, little is known about a number issues concerning kava (Piper methysticum), including (i) whether kava has any withdrawal or addictive effects; (ii) if genetic polymorphisms of the cytochrome (CYP) P450 2D6 liver enzyme moderates any potential adverse effects; and (iii) if medicinal application of kava has any negative or beneficial effect on sexual function and experience. The study design was a 6-week, double-blind, randomized controlled trial (n = 75) involving chronic administration of kava (one tablet of kava twice per day; 120 mg of kavalactones per day, titrated in non-response to two tablets of kava twice per day; 240 mg of kavalactones) or placebo for participants with generalized anxiety disorder. Results showed no significant differences across groups for liver function tests, nor were there any significant adverse reactions that could be attributed to kava. No differences in withdrawal or addiction were found between groups. Interesting, kava significantly increased female's sexual drive compared to placebo (p = 0.040) on a sub-domain of the Arizona Sexual Experience Scale (ASEX), with no negative effects seen in males. Further, it was found that there was a highly significant correlation between ASEX reduction (improved sexual function and performance) and anxiety reduction in the whole sample.

  15. Flavokawains A and B in Kava, Not Dihydromethysticin, Potentiate Acetaminophen-Induced Hepatotoxicity in C57BL/6 Mice

    PubMed Central

    2015-01-01

    Anxiolytic kava products have been associated with rare but severe hepatotoxicity in humans. This adverse potential has never been captured in animal models, and the responsible compound(s) remains to be determined. The lack of such knowledge greatly hinders the preparation of a safer kava product and limits its beneficial applications. In this study we evaluated the toxicity of kava as a single entity or in combination with acetaminophen (APAP) in C57BL/6 mice. Kava alone revealed no adverse effects for long-term usage even at a dose of 500 mg/kg bodyweight. On the contrary a three-day kava pretreatment potentiated APAP-induced hepatotoxicity, resulted in an increase in serum ALT and AST, and increased severity of liver lesions. Chalcone-based flavokawains A (FKA) and B (FKB) in kava recapitulated its hepatotoxic synergism with APAP while dihydromethysticin (DHM, a representative kavalactone and a potential lung cancer chemopreventive agent) had no such effect. These results, for the first time, demonstrate the hepatotoxic risk of kava and its chalcone-based FKA and FKB in vivo and suggest that herb–drug interaction may account for the rare hepatotoxicity associated with anxiolytic kava usage in humans. PMID:25185080

  16. Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study.

    PubMed

    Sarris, Jerome; Stough, Con; Bousman, Chad A; Wahid, Zahra T; Murray, Greg; Teschke, Rolf; Savage, Karen M; Dowell, Ashley; Ng, Chee; Schweitzer, Isaac

    2013-10-01

    Kava (Piper methysticum) is a plant-based medicine, which has been previously shown to reduce anxiety. To date, however, no placebo-controlled trial assessing kava in the treatment of generalized anxiety disorder (GAD) has been completed. A total of 75 participants with GAD and no comorbid mood disorder were enrolled in a 6-week double-blind trial of an aqueous extract of kava (120/240 mg of kavalactones per day depending on response) versus placebo. γ-Aminobutyric acid (GABA) and noradrenaline transporter polymorphisms were also analyzed as potential pharmacogenetic markers of response. Reduction in anxiety was measured using the Hamilton Anxiety Rating Scale (HAMA) as the primary outcome. Intention-to-treat analysis was performed on 58 participants who met inclusion criteria after an initial 1 week placebo run-in phase. Results revealed a significant reduction in anxiety for the kava group compared with the placebo group with a moderate effect size (P = 0.046, Cohen d = 0.62). Among participants with moderate to severe Diagnostic and Statistical Manual of Mental Disorders-diagnosed GAD, this effect was larger (P = 0.02; d = 0.82). At conclusion of the controlled phase, 26% of the kava group were classified as remitted (HAMA ≤ 7) compared with 6% of the placebo group (P = 0.04). Within the kava group, GABA transporter polymorphisms rs2601126 (P = 0.021) and rs2697153 (P = 0.046) were associated with HAMA reduction. Kava was well tolerated, and aside from more headaches reported in the kava group (P = 0.05), no other significant differences between groups occurred for any other adverse effects, nor for liver function tests. Standardized kava may be a moderately effective short-term option for the treatment of GAD. Furthermore, specific GABA transporter polymorphisms appear to potentially modify anxiolytic response to kava.

  17. German Kava Ban Lifted by Court: The Alleged Hepatotoxicity of Kava (Piper methysticum) as a Case of Ill-Defined Herbal Drug Identity, Lacking Quality Control, and Misguided Regulatory Politics.

    PubMed

    Kuchta, Kenny; Schmidt, Mathias; Nahrstedt, Adolf

    2015-12-01

    Kava, the rhizome and roots of Piper methysticum, are one of the most important social pillars of Melanesian societies. They have been used for more than 1000 years in social gatherings for the preparation of beverages with relaxing effects. During the colonial period, extract preparations found their way into Western medicinal systems, with experience especially concerning the treatment of situational anxiety dating back more than 100 years. It therefore came as a surprise when the safety of kava was suddenly questioned based on the observation of a series of case reports of liver toxicity in 1999 and 2000. These case reports ultimately led to a ban of kava products in Europe - a ban that has been contested because of the poor evidence of risks related to kava. Only recently, two German administrative courts decided that the decision of the regulatory authority to ban kava as a measure to ensure consumer safety was inappropriate and even associated with an increased risk due to the higher risk inherent to the therapeutic alternatives. This ruling can be considered as final for at least the German market, as no further appeal has been pursued by the regulatory authorities. However, in order to prevent further misunderstandings, especially in other markets, the current situation calls for a comprehensive presentation of the cardinal facts and misconceptions concerning kava and related drug quality issues.

  18. Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.

    PubMed

    Whittaker, Paul; Clarke, Jane J; San, Richard H C; Betz, Joseph M; Seifried, Harold E; de Jager, Lowri S; Dunkel, Virginia C

    2008-01-01

    Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both D-kawain and DL-kawain, were evaluated in L5178Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation. PMID:17822821

  19. Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice.

    PubMed

    Li, Xuesen; Liu, Zhongbo; Xu, Xia; Blair, Christopher A; Sun, Zheng; Xie, Jun; Lilly, Michael B; Zi, Xiaolin

    2012-01-01

    Men living in Fiji and drinking kava have low incidence of prostate cancer (PCa). However, the PCa incidence among Fijian men who had migrated to Australia, increased by 5.1-fold. We therefore examined the potential effects of kava root extracts and its active components (kavalactones and flavokawains) on PCa growth and androgen receptor (AR) expression. PCa cell lines (LNCaP, LAPC-4, 22Rv1, C4-2B, DU145 and PC-3) with different AR expression, and a transformed prostate myofibroblast cell line (WPMY-1), were treated with a commercial kava extract, kavalactones (kawain, 5'6'-dehydrokawain, yangonin, methysticin) and flavokawain B. Expression of AR and its target genes (PSA and TMPRSS2) was examined. Two novel patient-derived PCa xenograft models from high grade PCa specimens were established by implanting the specimens into nude mice and passing tumor pieces through subcutaneous injection in nude mice, and then treated with kava extract and flavokawain B to examine their effects on tumor growth, AR expression and serum PSA levels. The kava extract and flavokawain B effectively down-regulated the expression of both the full-length AR and AR splice variants. The kava extract and kavalactones accelerated AR protein degradation, while flavokawain B inhibited AR mRNA transcription via decreasing Sp1 expression and the binding of Sp1 to the AR promoter. The kava root extract and flavokawain B reduce tumor growth, AR expression in tumor tissues and levels of serum PSA in the patient-derived PCa xenograft models. These results suggest a potential usefulness of a safe kava product or its active components for prevention and treatment of advanced PCa by targeting AR. PMID:22347450

  20. Detection of flavokavins (A, B, C) in cultivars of kava (Piper methysticum) using high performance thin layer chromatography (HPTLC).

    PubMed

    Lebot, V; Do, T K T; Legendre, L

    2014-05-15

    Kava (Piper methysticum) is used to prepare the traditional beverage of the Pacific islands. In Europe, kava has been suspected to cause hepatoxicity with flavokavin B (FKB) considered as a possible factor. The present study describes an HPTLC protocol for rapid screening of samples. The objectives are: to detect the presence of flavokavins in extracts and to compare the FKB levels in different cultivars. Overall, 172 samples originating from four cultivars groups (noble, medicinal, two-days and wichmannii), were analysed. Results indicate that the ratio FKB/kavalactones is much higher in two-days (0.39) and wichmannii (0.32) compared to nobles (0.09) and medicinal cultivars (0.10). For each group, the ratios flavokavins/kavalactones do not change significantly between roots, stumps or basal stems and among clones, indicating that they are genetically controlled. This protocol has good accuracy and is cost efficient for routine analysis. We discuss how it could be used for quality control.

  1. Comparative analysis of genetic variation in kava (Piper methysticum) assessed by SSR and DArT reveals zygotic foundation and clonal diversification.

    PubMed

    Vandenbroucke, Henri; Mournet, Pierre; Malapa, Roger; Glaszmann, Jean-Christophe; Chaïr, Hana; Lebot, Vincent

    2015-01-01

    Kava (Piper methysticum) is a major cash crop in the Pacific. The aim of this study was to assess genetic variation among 103 accessions of kava using SSRs and DArTs. Genetic structure was determined using clustering analyses (WPGMA) and principal coordinate analyses (PCA). Thirteen SSR primers and 75 DArT markers were found polymorphic, and the two types of markers generated similar clustering patterns. Genetic distances ranged from 0 to 0.65 with an average of 0.24 using SSRs and from 0 to 0.64 with an average of 0.24 using DArT. Eleven genotypes were identified with SSR while 28 genotypes were identified with DArT markers. By combining the two sets of markers, a total of only 30 distinct genotypes were observed. In the Vanuatu archipelago, noble cultivars originating from different islands clustered together within a very narrow genetic base despite their diversity of morphotypes. SSR and DArT fingerprints allowed the identification of kava cultivars unsuitable for consumption, so called two-days, and clearly differentiated the wild types classified as P. methysticum var. wichmannii from the cultivars as var. methysticum. Molecular data reveals that all noble cultivars evolved by the predominance of clonal selection. Although they are represented by clearly distinct morphotypes, these cultivars are genetically vulnerable and their potential to adapt to forthcoming changes is limited. These newly developed markers provide high resolution and will be useful for kava diversity analyses and quality assessment.

  2. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism

    PubMed Central

    Chua, Han Chow; Christensen, Emilie T. H.; Hoestgaard-Jensen, Kirsten; Hartiadi, Leonny Y.; Ramzan, Iqbal; Jensen, Anders A.; Absalom, Nathan L.; Chebib, Mary

    2016-01-01

    Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest in kava, the molecular target(s) of the pharmacologically active constituents, kavalactones have not been established. γ-Aminobutyric acid type A receptors (GABAARs) are assumed to be the in vivo molecular target of kavalactones based on data from binding assays, but evidence in support of a direct interaction between kavalactones and GABAARs is scarce and equivocal. In this study, we characterised the functional properties of the major anxiolytic kavalactone, kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L (x = 1, 2, 3 and 5), α1βxγ2L (x = 1, 2 and 3) and α4β2δ GABAARs expressed in Xenopus oocytes using the two-electrode voltage clamp technique. We found that kavain positively modulated all receptors regardless of the subunit composition, but the degree of enhancement was greater at α4β2δ than at α1β2γ2L GABAARs. The modulatory effect of kavain was unaffected by flumazenil, indicating that kavain did not enhance GABAARs via the classical benzodiazepine binding site. The β3N265M point mutation which has been previously shown to profoundly decrease anaesthetic sensitivity, also diminished kavain-mediated potentiation. To our knowledge, this study is the first report of the functional characteristics of a single kavalactone at distinct GABAAR subtypes, and presents the first experimental evidence in support of a direct interaction between a kavalactone and GABAARs. PMID:27332705

  3. SiO Masers around WX Psc Mapped with the KVN and VERA Array (KaVA)

    NASA Astrophysics Data System (ADS)

    Yun, Youngjoo; Cho, Se-Hyung; Imai, Hiroshi; Kim, Jaeheon; Asaki, Yoshiharu; Chibueze, James O.; Choi, Yoon Kyung; Dodson, Richard; Kim, Dong-Jin; Kusuno, Kozue; Matsumoto, Naoko; Min, Cheulhong; Oyadomari, Miyako; Rioja, María J.; Yoon, Dong-Hwan; Byun, Do-Young; Chung, Hyunsoo; Chung, Moon-Hee; Hagiwara, Yoshiaki; Han, Myoung-Hee; Han, Seog-Tae; Hirota, Tomoya; Honma, Mareki; Hwang, Jung-Wook; Je, Do-Heung; Jike, Takaaki; Jung, Dong-Kyu; Jung, Taehyun; Kang, Ji-Hyun; Kang, Jiman; Kang, Yong-Woo; Kan-ya, Yukitoshi; Kanaguchi, Masahiro; Kawaguchi, Noriyuki; Kim, Bong Gyu; Ryoung Kim, Hyo; Kim, Hyun-Goo; Kim, Jongsoo; Kim, Kee-Tae; Kim, Mikyoung; Kobayashi, Hideyuki; Kono, Yusuke; Kurayama, Tomoharu; Lee, Changhoon; Lee, Jeewon; Lee, Jeong Ae; Lee, Jung-Won; Lee, Sang Hyun; Lee, Sang-Sung; Lyo, A.-Ran; Minh, Young Chol; Oh, Chungsik; Oh, Se-Jin; Oyama, Tomoaki; Roh, Duk-Gyoo; Sawada-Satoh, Satoko; Shibata, Katsunori M.; Sohn, Bong Won; Song, Min-Gyu; Tamura, Yoshiaki; Wi, Seog-Oh; Yeom, Jae-Hwan

    2016-05-01

    We present the first images of the v = 1 and v = 2 J = 1 → 0 SiO maser lines taken with KaVA, i.e., the combined array of the Korean Very Long Baseline Interferometry (VLBI) Network and the VLBI Exploration of Radio Astrometry (VERA), toward the OH/IR star WX Psc. The combination of long and short antenna baselines enabled us to detect a large number of maser spots, which exhibit a typical ring-like structure in both the v = 1 and v = 2 J = 1 → 0 SiO masers as those that have been found in previous VLBI observational results of WX Psc. The relative alignment of the v = 1 and v = 2 SiO maser spots are precisely derived from astrometric analysis, due to the absolute coordinates of the reference maser spot that were well determined in an independent astrometric observation with VERA. The superposition of the v = 1 and v = 2 maser spot maps shows a good spatial correlation between the v = 1 and v = 2 SiO maser features. Nevertheless, it is also shown that the v = 2 SiO maser spot is distributed in an inner region compared to the v = 1 SiO maser by about 0.5 mas on average. These results provide good support for the recent theoretical studies of the SiO maser pumping, in which both the collisional and the radiative pumping predict the strong spatial correlation and the small spatial discrepancy between the v = 1 and v = 2 SiO maser.

  4. THE FIRST VERY LONG BASELINE INTERFEROMETRY IMAGE OF A 44 GHz METHANOL MASER WITH THE KVN AND VERA ARRAY (KaVA)

    SciTech Connect

    Matsumoto, Naoko; Hirota, Tomoya; Honma, Mareki; Kameya, Osamu; Sunada, Kazuyoshi; Sugiyama, Koichiro; Motogi, Kazuhito; Kim, Kee-Tae; Kim, Mikyoung; Byun, Do-Young; Jung, Taehyun; Kim, Jongsoo; Lyo, A-Ran; Oh, Chungsik; Bae, Jaehan; Chung, Hyunsoo; Chung, Moon-Hee; Cho, Se-Hyung; Chibueze, James O.; Shino, Nagisa; and others

    2014-07-01

    We have carried out the first very long baseline interferometry (VLBI) imaging of a 44 GHz class I methanol maser (7{sub 0}-6{sub 1} A {sup +}) associated with a millimeter core MM2 in a massive star-forming region IRAS 18151–1208 with KaVA (KVN and VERA Array), which is a newly combined array of KVN (Korean VLBI Network) and VERA (VLBI Exploration of Radio Astrometry). We have succeeded in imaging compact maser features with a synthesized beam size of 2.7 milliarcseconds × 1.5 milliarcseconds (mas). These features are detected at a limited number of baselines within the length of shorter than ≈ 650 km corresponding to 100 Mλ in the uv-coverage. The central velocity and the velocity width of the 44 GHz methanol maser are consistent with those of the quiescent gas rather than the outflow traced by the SiO thermal line. The minimum component size among the maser features is ∼5 mas × 2 mas, which corresponds to the linear size of ∼15 AU × 6 AU assuming a distance of 3 kpc. The brightness temperatures of these features range from ∼3.5 × 10{sup 8} to 1.0 × 10{sup 10} K, which are higher than the estimated lower limit from a previous Very Large Array observation with the highest spatial resolution of ∼50 mas. The 44 GHz class I methanol maser in IRAS 18151–1208 is found to be associated with the MM2 core, which is thought to be less evolved than another millimeter core MM1 associated with the 6.7 GHz class II methanol maser.

  5. Orally administered grass pollen.

    PubMed

    Taudorf, E; Weeke, B

    1983-11-01

    In 1900 it was claimed that oral administration of ragweed could be used for the hyposensitization of hay fever patients. Several uncontrolled trials have been published, all showing an effect of oral hyposensitization. Only one study was controlled and showed no effect of oral hyposensitization. It was decided to undertake controlled clinical trials to determine the safety and effectiveness of orally administered enteric-coated grass pollen tablets in patients with hay fever. The actual grass pollen dose in the first trial was 30 times the dose that is normally recommended for preseasonal oral pollen hyposensitization using pollen aqueous solution or pollen powder. The safety study will be described here. Twelve young adults with a history of grass pollen hay fever positive skin prick test and positive nasal provocation test with extracts of timothy grass pollen were randomly allocated to one of the treatment groups with four patients in each group taking enteric-coated Conjuvac Timothy tablets or enteric-coated Whole Timothy pollen tablets or enteric-coated placebo tablets. The study was double blind. Preseasonally, the patients received 342,500 PNU and in total they received 4,500,000 PNU during 6 months. The patients receiving active treatment did not have any side effects. No significant changes were shown in the skin and nasal reactivity to grass pollen during the study. Neither were there any changes in timothy-specific IgE, IgG, total IgE nor histamine liberation from basophils.

  6. Herbal Products and Your Anesthestic

    MedlinePlus

    ... Biloba, Ginseng, Hoodia, Kava, St. John’s Wort, and Valerian. Herbal products are available as tablets, liquids, granules, ... with other medications that prolong effects of anesthesia. Valerian Increased sedative effects.

  7. A guide to herbal remedies

    MedlinePlus

    ... effects. Here are some examples: Kava is an herb used for anxiety, insomnia, symptoms of menopause, and ... about specific herbal supplements: NIH MedlinePlus database of herbs and supplements -- www.nlm.nih.gov/medlineplus/druginfo/ ...

  8. Anxiety, depression, and insomnia.

    PubMed

    Larzelere, Michele M; Wiseman, Pamela

    2002-06-01

    Evidence for alternative treatments for depression, anxiety, and insomnia are reviewed in this article. Treatment of depression with St. John's wort, L-tryptophan, 5-hydroxytryptophan, S-adenosylmethionine, dehydroepiandosterone, folate, exercise, acupuncture, and meditation are examined. Evidence for the efficacy of kava kava, exercise, relaxation therapies, and acupuncture in treatment anxiety is reviewed. The use of valerian, melatonin, chamomile, passionflower, exercise, acupuncture, and behavioral therapies (i.e., sleep restriction, stimulus control, relaxation, and sleep hygiene) for insomnia is discussed.

  9. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  10. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  11. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  12. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  13. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  14. Herbal medicine for insomnia: A systematic review and meta-analysis.

    PubMed

    Leach, Matthew J; Page, Amy T

    2015-12-01

    Insomnia is a prevalent sleep disorder that can profoundly impact a person's health and wellbeing. Herbal medicine represents one of the most frequently used complementary and alternative treatments of insomnia. However, the safety and efficacy of herbal medicine for the treatment of this disorder is currently uncertain. In order to ascertain the evidence base for herbal medicine for insomnia, we systematically searched seventeen electronic databases and the reference lists of included studies for relevant randomised controlled trials (RCTs). Fourteen RCTs, involving a total of 1602 participants with insomnia, met the inclusion criteria. Four distinct orally administered herbal monopreparations were identified (i.e., valerian, chamomile, kava and wuling). There was no statistically significant difference between any herbal medicine and placebo, or any herbal medicine and active control, for any of the thirteen measures of clinical efficacy. As for safety, a similar or smaller number of adverse events per person were reported with kava, chamomile and wuling when compared with placebo. By contrast, a greater number of events per person were reported with valerian. While there is insufficient evidence to support the use of herbal medicine for insomnia, there is a clear need for further research in this area. PMID:25644982

  15. Herbal medicine for insomnia: A systematic review and meta-analysis.

    PubMed

    Leach, Matthew J; Page, Amy T

    2015-12-01

    Insomnia is a prevalent sleep disorder that can profoundly impact a person's health and wellbeing. Herbal medicine represents one of the most frequently used complementary and alternative treatments of insomnia. However, the safety and efficacy of herbal medicine for the treatment of this disorder is currently uncertain. In order to ascertain the evidence base for herbal medicine for insomnia, we systematically searched seventeen electronic databases and the reference lists of included studies for relevant randomised controlled trials (RCTs). Fourteen RCTs, involving a total of 1602 participants with insomnia, met the inclusion criteria. Four distinct orally administered herbal monopreparations were identified (i.e., valerian, chamomile, kava and wuling). There was no statistically significant difference between any herbal medicine and placebo, or any herbal medicine and active control, for any of the thirteen measures of clinical efficacy. As for safety, a similar or smaller number of adverse events per person were reported with kava, chamomile and wuling when compared with placebo. By contrast, a greater number of events per person were reported with valerian. While there is insufficient evidence to support the use of herbal medicine for insomnia, there is a clear need for further research in this area.

  16. Relaxation processes in administered-rate pricing

    NASA Astrophysics Data System (ADS)

    Hawkins, Raymond J.; Arnold, Michael R.

    2000-10-01

    We show how the theory of anelasticity unifies the observed dynamics and proposed models of administered-rate products. This theory yields a straightforward approach to rate model construction that we illustrate by simulating the observed relaxation dynamics of two administered rate products. We also demonstrate how the use of this formalism leads to a natural definition of market friction.

  17. 22 CFR 196.4 - Administering office.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Administering office. 196.4 Section 196.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.4 Administering office. The Department of...

  18. 22 CFR 196.4 - Administering office.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Administering office. 196.4 Section 196.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.4 Administering office. The Department of...

  19. 22 CFR 196.4 - Administering office.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Administering office. 196.4 Section 196.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.4 Administering office. The Department of...

  20. 22 CFR 196.4 - Administering office.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Administering office. 196.4 Section 196.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.4 Administering office. The Department of...

  1. 22 CFR 196.4 - Administering office.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Administering office. 196.4 Section 196.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.4 Administering office. The Department of...

  2. Teaching Students to Administer the WISC

    ERIC Educational Resources Information Center

    Ritter, Kathleen Yost

    1977-01-01

    A college level psychology course is described in which students were trained by both traditional and experimental methods to administer individual intelligence tests. Comparative analysis of performance by each group indicates that student motivation and performance is not greatly influenced by teaching method and that videotape demonstrations…

  3. Changes in Medications Administered in Schools

    ERIC Educational Resources Information Center

    McCarthy, Ann Marie; Kelly, Michael W.; Johnson, Shella; Roman, Jaclyn; Zimmerman, M. Bridget

    2006-01-01

    The purpose of this descriptive, cross-sectional study was to determine if there have been changes in the type and number of attention deficit/hyperactivity disorder (AD/HD) medications administered in schools since the introduction of long-acting stimulants. A survey was sent to 1,000 school nurses randomly selected from the National Association…

  4. Determination of Aflatoxins in Botanical Roots by a Modification of AOAC Official MethodSM 991.31: Single-Laboratory Validation

    PubMed Central

    Weaver, Carol M.; Trucksess, Mary W.

    2010-01-01

    AOAC Official MethodSM 991.31 for the determination of aflatoxins (AFs; sum of aflatoxins B1, B2, G1, and G2) in corn, raw peanuts, and peanut butter by using immunoaffinity column cleanup with LC has been modified and applied to the determination of AFs in botanical roots. The modifications were necessary to improve the performance of the method for matrixes beyond corn and peanuts. The extraction solvent was changed from a mixture of methanol and water to acetonitrile and water. The accuracy, repeatability, and reproducibility characteristics of this method were determined. Replicates of 10 test portions of each powdered root (black cohosh, echinacea, ginger, ginseng, kava kava, and valerian) at each spiking level (AFs at 0, 2, 4, 8, and 16 ng/g) were analyzed on 3 separate days. Test portions were extracted with acetonitrile–water (84 + 16, v/v), and the extracts were centrifuged, diluted with phosphate-buffered saline, filtered, and applied to an immunoaffinity column containing antibodies specific for AFs. After the column was washed with water, the toxins were eluted from the column with methanol and quantified by HPLC with fluorescence detection. All test materials except kava kava were found to contain AF at <0.1 ng/g. Kava kava was naturally contaminated with AFs at 0.5 ng/g. Average within-day and between-days recoveries of AFs from botanical roots ranged from 88 to 112 and from 86 to 118%, respectively. Total RSD values for within-day and between-days repeatability ranged from 1.4 to 15.9%. HorRat values were <0.4 for all of the matrixes examined. The modified AOAC Official Method 991.31 was found to be applicable to an analysis of the six botanical roots. PMID:20334179

  5. Trials of intranasally administered rubella vaccine.

    PubMed

    Hillary, I B

    1971-12-01

    No evidence of vaccine virus transmission was found in two studies where Wistar RA 27/3 rubella vaccine was administered intranasally. Vaccine was immunogenic in all of 23 vaccinated children in one study, while in the other only 5 of the 11 vaccinees developed antibody. The reduced seroconversion rate in the latter study appears to have been caused by one or a combination of factors, including the vaccination technique, the presence of infective nasal conditions in vaccinees and the titre of vaccine used.

  6. Ocular toxicity from systemically administered xenobiotics

    PubMed Central

    Gokulgandhi, Mitan R; Vadlapudi, Aswani Dutt; Mitra, Ashim K

    2015-01-01

    Introduction The eye is considered as the most privileged organ because of the blood–ocular barrier that acts as a barrier to systemically administered xenobiotics. However, there has been a significant increase in the number of reports on systemic drug-induced ocular complications. If such complications are left untreated, then it may cause permanent damage to vision. Hence, knowledge of most recent updates on ever-increasing reports of such toxicities has become imperative to develop better therapy while minimizing toxicities. Areas covered The article is mainly divided into anterior and posterior segment manifestations caused by systemically administered drugs. The anterior segment is further elaborated on corneal complications where as the posterior segment is focused on optic nerve, retinal and vitreous complications. Furthermore, this article includes recent updates on acute and chronic ocular predicaments, in addition to discussing various associated symptoms caused by drugs. Expert opinion Direct correlation of ocular toxicities due to systemic drug therapy is evident from current literature. Therefore, it is necessary to have detailed documentation of these complications to improve understanding and predict toxicities. We made an attempt to ensure that the reader is aware of the characteristic ocular complications, the potential for irreversible drug toxicity and indications for cessation. PMID:22803583

  7. Updates on Nutraceutical Sleep Therapeutics and Investigational Research.

    PubMed

    Yurcheshen, Michael; Seehuus, Martin; Pigeon, Wilfred

    2015-01-01

    Approximately 50% of the population will suffer from a sleep disorder over the course of their lifetime. There is increasing interest in nutraceuticals for these conditions. The quality of the evidence for the safety and effectiveness of using these supplements to treat sleep disorders varies substantially. In this review, we discuss the data about the effectiveness and safety of six commonly used plant-based sleep therapeutics: caffeine, chamomile, cherries, kava kava, L-tryptophan, marijuana, and valerian. We explore both historical uses of each substance and the current state of the literature. PMID:26265921

  8. Updates on Nutraceutical Sleep Therapeutics and Investigational Research

    PubMed Central

    Yurcheshen, Michael; Seehuus, Martin; Pigeon, Wilfred

    2015-01-01

    Approximately 50% of the population will suffer from a sleep disorder over the course of their lifetime. There is increasing interest in nutraceuticals for these conditions. The quality of the evidence for the safety and effectiveness of using these supplements to treat sleep disorders varies substantially. In this review, we discuss the data about the effectiveness and safety of six commonly used plant-based sleep therapeutics: caffeine, chamomile, cherries, kava kava, L-tryptophan, marijuana, and valerian. We explore both historical uses of each substance and the current state of the literature. PMID:26265921

  9. Absorption of orally administered amphotericin B lozenges.

    PubMed

    Ching, M S; Raymond, K; Bury, R W; Mashford, M L; Morgan, D J

    1983-07-01

    The systemic absorption of amphotericin B, administered as a 10 mg lozenge, was investigated in 14 patients with malignancies, who received three or four doses daily during chronic administration. The mean plasma amphotericin B concentration, measured 3 h after the morning dose on from 1-20 occasions over a 1-80 day period, ranged among subjects from 46 +/- 13 ng/ml (s.d., n = 20) to 136 +/- 25 ng/ml (n = 19). Using the previously reported intravenous clearance of the drug, the fraction of the dose absorbed was estimated at 8.3-9.9%. This is considerably greater than that estimated from earlier reports (0.2-0.9%), which used much higher oral doses (2-10 g/day). PMID:6882617

  10. The radiation dosimetry of intrathecally administered radionuclides

    SciTech Connect

    Stabin, M.G.; Evans, J.F.

    1999-01-01

    The radiation dose to the spine, spinal cord, marrow, and other organs of the body from intrathecal administration of several radiopharmaceuticals was studied. Anatomic models were developed for the spine, spinal cerebrospinal fluid (CSF), spinal cord, spinal skeleton, cranial skeleton, and cranial CSF. A kinetic model for the transport of CSF was used to determine residence times in the CSF; material leaving the CSF was thereafter assumed to enter the bloodstream and follow the kinetics of the radiopharmaceutical as if intravenously administered. The radiation transport codes MCNP and ALGAMP were used to model the electron and photon transport and energy deposition. The dosimetry of Tc-99m DTPA and HSA, In-111 DTPA, I-131 HSA, and Yb-169 DTPA was studied. Radiation dose profiles for the spinal cord and marrow in the spine were developed and average doses to all other organs were estimated, including dose distributions within the bone and marrow.

  11. Efficacy of intravenously administered ibandronate in postmenopausal Korean women with insufficient response to orally administered bisphosphonates.

    PubMed

    Bae, Sung Jin; Kim, Beom-Jun; Lim, Kyeong Hye; Lee, Seung Hun; Kim, Hong Kyu; Kim, Ghi Su; Koh, Jung-Min

    2012-09-01

    We investigated rates of insufficient and over-responsiveness to orally administered bisphosphonates in postmenopausal women, and tested the efficacy of intravenous ibandronate in patients with insufficient response to orally administered bisphosphonates. Postmenopausal women were treated with either alendronate (70 mg/week; n = 88) or risedronate (35 mg/week; n = 84) for 1 year, and their response to orally administered bisphosphonates was assessed using serum C-telopeptide (CTX) levels. Insufficient responders were changed to once-quarterly intravenous ibandronate 3 mg injection (n = 13) or maintained on orally administered bisphosphonates (n = 19), according to patients' preference, for an additional 1 year. There was no significant difference in baseline characteristics between two orally administered bisphosphonate groups except the bone mineral density values at the lumbar spine. Insufficient rate was higher in the risedronate group (19.0 %) than in the alendronate group (8.0 %), using the premenopausal serum CTX median as a cut-off (P = 0.043). The over-response rate among the alendronate group (59.1 %) was significantly higher than that in the risedronate group (38.1 %), based on a serum CTX cut-off value of 0.100 ng/ml (P = 0.006). Intravenous ibandronate suppressed serum CTX levels to a significantly greater degree at 7 days after the second dosing (0.191 ± 0.110 ng/mL; P < 0.001) and 3 months after the fourth dosing (0.274 ± 0.159 ng/mL; P = 0.004) among insufficient responders, compared with post-oral/pre-intravenous levels (0.450 ± 0.134 ng/mL). Rates of insufficient and over-responsiveness to orally administered bisphosphonates were considerable, and a change to intravenous bisphosphonates may be considered in patients showing an insufficient response to orally administered bisphosphonates.

  12. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  13. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  14. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  15. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  16. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  17. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... examination. The administering VEs are responsible for the proper conduct and necessary supervision of each examination. The administering VEs must immediately terminate the examination upon failure of the examinee...

  18. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... administering VEs are responsible for the proper conduct and necessary supervision of each examination. The administering VEs must immediately terminate the examination upon failure of the examinee to comply with...

  19. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... examination. The administering VEs are responsible for the proper conduct and necessary supervision of each examination. The administering VEs must immediately terminate the examination upon failure of the examinee...

  20. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... examination. The administering VEs are responsible for the proper conduct and necessary supervision of each examination. The administering VEs must immediately terminate the examination upon failure of the examinee...

  1. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... examination. The administering VEs are responsible for the proper conduct and necessary supervision of each examination. The administering VEs must immediately terminate the examination upon failure of the examinee...

  2. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  3. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  4. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  5. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  6. Targeted Lung Delivery of Nasally Administered Aerosols

    PubMed Central

    Tian, Geng; Hindle, Michael; Longest, P. Worth

    2014-01-01

    Using the nasal route to deliver pharmaceutical aerosols to the lungs has a number of advantages including co-administration during non-invasive ventilation. The objective of this study was to evaluate the growth and deposition characteristics of nasally administered aerosol throughout the conducting airways based on delivery with streamlined interfaces implementing two forms of controlled condensational growth technology. Characteristic conducting airways were considered including a nose-mouth-throat (NMT) geometry, complete upper tracheobronchial (TB) model through the third bifurcation (B3), and stochastic individual path (SIP) model to the terminal bronchioles (B15). Previously developed streamlined nasal cannula interfaces were used for the delivery of submicrometer particles using either enhanced condensational growth (ECG) or excipient enhanced growth (EEG) techniques. Computational fluid dynamics (CFD) simulations predicted aerosol transport, growth and deposition for a control (4.7 μm) and three submicrometer condensational aerosols with budesonide as a model insoluble drug. Depositional losses with condensational aerosols in the cannula and NMT were less than 5% of the initial dose, which represents an order-of-magnitude reduction compared to the control. The condensational growth techniques increased the TB dose by a factor of 1.1–2.6x, delivered at least 70% of the dose to the alveolar region, and produced final aerosol sizes ≥2.5 μm. Compared to multiple commercial orally inhaled products, the nose-to-lung delivery approach increased dose to the biologically important lower TB region by factors as large as 35x. In conclusion, nose-to-lung delivery with streamlined nasal cannulas and condensational aerosols was highly efficient and targeted deposition to the lower TB and alveolar regions. PMID:24932058

  7. Who Should Administer Energy-Efficiency Programs?

    SciTech Connect

    Blumstein, Carl; Goldman, Charles; Barbose, Galen L.

    2003-05-01

    The restructuring of the electric utility industry in the US created a crisis in the administration of ratepayer-funded energy-efficiency programs. Before restructuring, nearly all energy-efficiency programs in the US were administered by utilities and funded from utility rates. Restructuring called these arrangements into question in two ways. First, the separation of generation from transmission and distribution undermined a key rationale for utility administration. This was the Integrated Resource Planning approach in which the vertically integrated utility was given incentives to provide energy services at least cost. Second, questions were raised as to whether funding through utility rates could be sustained in a competitive environment and most states that restructured their electricity industry adopted a system benefits charge. The crisis in administration of energy-efficiency programs produced a variety of responses in the eight years since restructuring in the US began in earn est. These responses have included new rationales for energy-efficiency programs, new mechanisms for funding programs, and new mechanisms for program administration and governance. This paper focuses on issues related to program administration. It describes the administrative functions and some of the options for accomplishing them. Then it discusses criteria for choosing among the options. Examples are given that highlight some of the states that have made successful transitions to new governance and/or administration structures. Attention is also given to California where large-scale energy-efficiency programs have continued to operate, despite the fact that many of the key governance/administration issues remain unresolved. The conclusion attempts to summarize lessons learned.

  8. Noninvasive Imaging of Administered Progenitor Cells

    SciTech Connect

    Steven R Bergmann, M.D., Ph.D.

    2012-12-03

    -99% pure population of leukocytes. Viability was assessed using Trypan blue histological analysis. We successfully isolated and labeled ~25-30 x 10{sup 7} CD34+ lymphocytes in cytokine mobilized progenitor cell apharesis harvests. Cells were also subjected to a stat gram stain to look for bacterial contamination, stat endotoxin LAL to look for endotoxin contamination, flow cytometry for evaluation of the purity of the cells and 14-day sterility culture. Colony forming assays confirm the capacity of these cells to proliferate and function ex-vivo with CFU-GM values of 26 colonies/ 1 x 10{sup 4} cells plated and 97% viability in cytokine augmented methylcellulose at 10-14 days in CO{sub 2} incubation. We developed a closed-processing system for the product labeling prior to infusion to maintain autologous cell integrity and sterility. Release criteria for the labeled product were documented for viability, cell count and differential, and measured radiolabel. We were successful in labeling the cells with up to 500 uCi/10{sup 8} cells, with viability of >98%. However, due to delays in getting the protocol approved by the FDA, the cells were not infused in humans in this location (although we did successfully use CD34+ cells in humans in a study in Australia). The approach developed should permit labeling of progenitor cells that can be administered to human subjects for tracking. The labeling approach should be useful for all progenitor cell types, although this would need to be verified since different cell lines may have differential radiosensitivity.

  9. 24 CFR 982.51 - PHA authority to administer program.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false PHA authority to administer program. 982.51 Section 982.51 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN... PHA Plan for Administration of Program § 982.51 PHA authority to administer program. (a) The PHA...

  10. 40 CFR 147.150 - State-administered program. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. 147.150 Section 147.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona §...

  11. 40 CFR 147.150 - State-administered program. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false State-administered program. 147.150 Section 147.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona §...

  12. 40 CFR 147.150 - State-administered program. [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false State-administered program. 147.150 Section 147.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona §...

  13. 40 CFR 147.1200 - State-administered program. [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false State-administered program. 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota §...

  14. 40 CFR 147.1200 - State-administered program. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota §...

  15. 40 CFR 147.1200 - State-administered program. [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false State-administered program. 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota §...

  16. 40 CFR 147.1200 - State-administered program. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false State-administered program. 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota §...

  17. 40 CFR 147.1200 - State-administered program. [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false State-administered program. 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota §...

  18. 40 CFR 147.1650 - State-administered program. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. 147.1650 Section 147.1650 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS New York §...

  19. 7 CFR 634.30 - Appeals in USDA administered projects.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Appeals in USDA administered projects. 634.30 Section 634.30 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES... RCWP Contracts § 634.30 Appeals in USDA administered projects. The participant in a...

  20. 7 CFR 634.30 - Appeals in USDA administered projects.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Appeals in USDA administered projects. 634.30 Section 634.30 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES... RCWP Contracts § 634.30 Appeals in USDA administered projects. The participant in a...

  1. 7 CFR 634.30 - Appeals in USDA administered projects.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Appeals in USDA administered projects. 634.30 Section 634.30 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES... RCWP Contracts § 634.30 Appeals in USDA administered projects. The participant in a...

  2. 7 CFR 634.30 - Appeals in USDA administered projects.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Appeals in USDA administered projects. 634.30 Section 634.30 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES... RCWP Contracts § 634.30 Appeals in USDA administered projects. The participant in a...

  3. 7 CFR 634.30 - Appeals in USDA administered projects.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Appeals in USDA administered projects. 634.30 Section 634.30 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES... RCWP Contracts § 634.30 Appeals in USDA administered projects. The participant in a...

  4. 40 CFR 147.2350 - State-administered program. [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false State-administered program. 147.2350 Section 147.2350 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia §...

  5. 40 CFR 147.2350 - State-administered program. [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false State-administered program. 147.2350 Section 147.2350 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia §...

  6. 40 CFR 147.2350 - State-administered program. [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false State-administered program. 147.2350 Section 147.2350 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia §...

  7. 40 CFR 147.2350 - State-administered program. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. 147.2350 Section 147.2350 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia §...

  8. 49 CFR 7.22 - Who administers this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Who administers this subpart? 7.22 Section 7.22 Transportation Office of the Secretary of Transportation PUBLIC AVAILABILITY OF INFORMATION Availability of Reasonably Described Records Under the Freedom of Information Act § 7.22 Who administers this subpart? (a) A Chief FOIA Officer is appointed...

  9. 40 CFR 147.3000 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... administered by EPA. (The term “Indian lands” is defined at 40 CFR 144.3.) The Navajo Indian lands are in the... Utah. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and..., Ute Mountain Ute, and All Other New Mexico Tribes § 147.3000 EPA-administered program. (a)...

  10. 40 CFR 147.3000 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administered by EPA. (The term “Indian lands” is defined at 40 CFR 144.3.) The Navajo Indian lands are in the... Utah. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and..., Ute Mountain Ute, and All Other New Mexico Tribes § 147.3000 EPA-administered program. (a)...

  11. 40 CFR 147.1550 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Director of the Federal Register on June 25, 1984. (1) Water Pollution Control Act, New Jersey Statutes... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS New Jersey § 147.1550 State-administered program. The UIC program for all classes of wells in the State of New Jersey,...

  12. 40 CFR 147.1651 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Indian lands, is administered by EPA. The program consists of the UIC program requirements of 40 CFR... Seneca Indian Tribe is June 25, 1984. The effective date for the UIC program for the lands of the...

  13. Findings from Survey Administered to Weatherization Training Centers

    SciTech Connect

    Conlon, Brian; Tonn, Bruce Edward

    2015-03-01

    This report summarizes results of a survey administered to directors of weatherization training centers that receive funding from the U.S. Department of Energy. The survey presents results related to questions on training offered and future plans.

  14. Determinants of nurses' intention to administer opioids for pain relief.

    PubMed

    Edwards, H E; Nash, R E; Najman, J M; Yates, P M; Fentiman, B J; Dewar, A; Walsh, A M; McDowell, J K; Skerman, H M

    2001-09-01

    A statewide cross-sectional survey was conducted in Australia to identify the determinants of registered nurses' intention to administer opioids to patients with pain. Attitudes, subjective norms and perceived control, the key determinants of the Theory of Planned Behavior, were found to independently predict nurses' intention to administer opioids to these patients. Perceived control was the strongest predictor. Nurses reported positive overall attitudes towards opioids and their use in pain management. However, many negative attitudes were identified; for example, administering the least amount of opioid and encouraging patients to have non-opioids rather than opioids for pain relief. The findings related to specific attitudes and normative pressures provide insight into registered nurses' management of pain for hospitalized patients and the direction for educational interventions to improve registered nurses' administration of opioids for pain management.

  15. Pediatric nurses' thinking in response to vignettes on administering analgesics.

    PubMed

    Van Hulle Vincent, Catherine; Gaddy, Erica J

    2009-10-01

    Pediatric nurses are not administering available and recommended analgesics to hospitalized children after surgery. This descriptive study was conducted to examine 30 pediatric nurses' thinking-in response to case study vignettes-about pain assessment and morphine administration for children experiencing postoperative pain. Nurses considered numerous factors when assessing and managing children's pain, including pain level, vital signs, and facial expression. Nurses frequently relied, however, on behavioral and physiological manifestations, as opposed to self-report, when choosing whether to administer morphine. Nurses demonstrated misconceptions about pharmacokinetics and unwarranted concerns about the adverse effects of morphine. These findings partly explain why children continue to report high levels of pain after surgery and why nurses may not administer adequate analgesics to relieve children's pain. PMID:19504564

  16. Systemic Effects of Vaginally Administered Estrogen Therapy: A Review

    PubMed Central

    Krause, Megan; Wheeler, Thomas L.; Richter, Holly E.; Snyder, Thomas E.

    2015-01-01

    Hormone Therapy (HT) was considered the standard of care prior to the publication of the Women’s Health Initiative (WHI). After the study was published, the use of systemic HT dramatically decreased resulting in an increased incidence of menopausal symptoms such as hot flashes, vaginal dryness and dyspareunia experienced by women. Use of vaginal estrogen offers women a unique alternative for relief of these symptoms. This article reviews the systemic effects of vaginally administered estrogen. Effects on serum hormone levels, vasomotor symptoms, lipid profiles and use in women with breast cancer are reviewed. An accompanying review examines the local effects of vaginally administered estrogen. PMID:22453284

  17. A Mobile Platform for Administering Questionnaires and Synchronizing Their Answers

    ERIC Educational Resources Information Center

    Ginardi, Maria Germana; Lanzola, Giordano

    2013-01-01

    This paper describes a platform for administering questionnaires on smart-phones and tablets. The project arises from the need of acquiring data for monitoring the outcomes of different homecare interventions. First a model has been defined for representing questionnaires, able to support adaptivity in the dialog with the user and enforce some…

  18. 40 CFR 282.88 - Pennsylvania State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Bureau of Land Recycling and Waste Management, Storage Tank Program, Rachel Carson State Office Building... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.88 Pennsylvania State-Administered Program. (a) The Commonwealth of Pennsylvania's underground storage...

  19. 40 CFR 147.2300 - State-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Underground Water Source Protection Program Pursuant to the Safe Drinking Water Act and 40 CFR 145... was approved by the Director of the Federal Register July 6, 1984. (1) Vt. Stat. Ann. tit. 10... are part of the approved State-administered program: (1) Vt. Stat. Ann. tit. 10, sections 1251...

  20. 40 CFR 147.2300 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Underground Water Source Protection Program Pursuant to the Safe Drinking Water Act and 40 CFR 145... was approved by the Director of the Federal Register July 6, 1984. (1) Vt. Stat. Ann. tit. 10... are part of the approved State-administered program: (1) Vt. Stat. Ann. tit. 10, sections 1251...

  1. 40 CFR 282.73 - Minnesota State-Administered Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Minnesota obtains... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Minnesota State-Administered Program... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.73...

  2. 40 CFR 282.73 - Minnesota State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Minnesota obtains... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Minnesota State-Administered Program... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.73...

  3. 40 CFR 282.73 - Minnesota State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Minnesota obtains... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Minnesota State-Administered Program... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.73...

  4. 40 CFR 282.66 - Kansas State-Administered Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Kansas obtains approval for the revised requirements pursuant... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Kansas... subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and regulatory...

  5. 40 CFR 282.78 - Nevada State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Nevada obtains approval for the revised... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The state's program, as administered by the Nevada... of Subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and...

  6. 40 CFR 282.78 - Nevada State-Administered Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Nevada obtains approval for the revised... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The state's program, as administered by the Nevada... of Subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and...

  7. 40 CFR 282.66 - Kansas State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Kansas obtains approval for the revised requirements pursuant... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Kansas... subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and regulatory...

  8. 40 CFR 282.66 - Kansas State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Kansas obtains approval for the revised requirements pursuant... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Kansas... subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and regulatory...

  9. 40 CFR 282.78 - Nevada State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Nevada obtains approval for the revised... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The state's program, as administered by the Nevada... of Subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and...

  10. 40 CFR 282.78 - Nevada State-Administered Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Nevada obtains approval for the revised... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The state's program, as administered by the Nevada... of Subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and...

  11. 40 CFR 282.66 - Kansas State-Administered Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Kansas obtains approval for the revised requirements pursuant... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Kansas... subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and regulatory...

  12. 40 CFR 282.66 - Kansas State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Kansas obtains approval for the revised requirements pursuant... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Kansas... subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and regulatory...

  13. 40 CFR 282.78 - Nevada State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Nevada obtains approval for the revised... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The state's program, as administered by the Nevada... of Subtitle I of RCRA, 42 U.S.C. 6991d and 6991e, as well as under other statutory and...

  14. Microcomputer-Administered Research: What it Means for Educational Researchers.

    ERIC Educational Resources Information Center

    Johnson, Craig W.

    1982-01-01

    The development of the microcomputer offers advantages for behavioral science and educational research. Among the potentials of microcomputer use are enhanced capacities for precise replication and extension, measurement, and experimental control and randomization, and the relative economy that microcomputer-administered experimental treatments…

  15. 40 CFR 282.94 - Utah State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Utah obtains approval for the revised requirements pursuant to... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Utah State-Administered Program. 282.94 Section 282.94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

  16. 40 CFR 282.61 - Hawaii State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Hawaii obtains approval for the revised requirements pursuant... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Hawaii State-Administered Program. 282.61 Section 282.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

  17. 40 CFR 282.61 - Hawaii State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... 6991c, and 40 CFR part 281, subpart E. If Hawaii obtains approval for the revised requirements pursuant... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Hawaii State-Administered Program. 282.61 Section 282.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

  18. 40 CFR 147.1100 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 147.1100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS..., except those on Indian lands, is the program administered by the Massachusetts Department of... Department of Environmental Quality Engineering, signed by the EPA Regional Administrator on August 18,...

  19. 40 CFR 282.53 - Arkansas State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If... administered by the Arkansas Department of Pollution Control and Ecology, was approved by EPA pursuant to 42 U... Pollution Control and Ecology, 8001 National Drive, Little Rock, AR 72219-8913. (1) State statutes...

  20. 40 CFR 282.53 - Arkansas State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If... administered by the Arkansas Department of Pollution Control and Ecology, was approved by EPA pursuant to 42 U... Pollution Control and Ecology, 8001 National Drive, Little Rock, AR 72219-8913. (1) State statutes...

  1. 40 CFR 282.53 - Arkansas State-Administered Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If... administered by the Arkansas Department of Pollution Control and Ecology, was approved by EPA pursuant to 42 U... Pollution Control and Ecology, 8001 National Drive, Little Rock, AR 72219-8913. (1) State statutes...

  2. 40 CFR 282.53 - Arkansas State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If... administered by the Arkansas Department of Pollution Control and Ecology, was approved by EPA pursuant to 42 U... Pollution Control and Ecology, 8001 National Drive, Little Rock, AR 72219-8913. (1) State statutes...

  3. 40 CFR 282.53 - Arkansas State-Administered Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If... administered by the Arkansas Department of Pollution Control and Ecology, was approved by EPA pursuant to 42 U... Pollution Control and Ecology, 8001 National Drive, Little Rock, AR 72219-8913. (1) State statutes...

  4. 24 CFR 511.51 - State-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL REHABILITATION GRANT PROGRAM State Program... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false State-administered program. 511.51 Section 511.51 Housing and Urban Development Regulations Relating to Housing and Urban...

  5. 24 CFR 511.51 - State-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL REHABILITATON GRANT PROGRAM State Program... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true State-administered program. 511.51 Section 511.51 Housing and Urban Development Regulations Relating to Housing and Urban...

  6. 24 CFR 511.51 - State-administered program.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL REHABILITATION GRANT PROGRAM State Program... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false State-administered program. 511.51 Section 511.51 Housing and Urban Development Regulations Relating to Housing and Urban...

  7. 24 CFR 511.51 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL REHABILITATON GRANT PROGRAM State Program... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false State-administered program. 511.51 Section 511.51 Housing and Urban Development Regulations Relating to Housing and Urban...

  8. 24 CFR 511.51 - State-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL REHABILITATION GRANT PROGRAM State Program... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true State-administered program. 511.51 Section 511.51 Housing and Urban Development Regulations Relating to Housing and Urban...

  9. 40 CFR 282.96 - Virginia State-Administered Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Virginia State-Administered Program... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.96...

  10. 40 CFR 282.96 - Virginia State-Administered Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Virginia State-Administered Program... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.96...

  11. 40 CFR 147.3000 - EPA-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... administered by EPA. (The term “Indian lands” is defined at 40 CFR 144.3.) The Navajo Indian lands are in the.... The UIC program for Navajo Indian lands, except for Class II wells on Navajo Indian lands for which..., except for Class II wells on Navajo Indian lands for which EPA has granted the Navajo Nation primacy......

  12. 40 CFR 147.3000 - EPA-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... administered by EPA. (The term “Indian lands” is defined at 40 CFR 144.3.) The Navajo Indian lands are in the.... The UIC program for Navajo Indian lands, except for Class II wells on Navajo Indian lands for which..., except for Class II wells on Navajo Indian lands for which EPA has granted the Navajo Nation primacy......

  13. 40 CFR 147.3000 - EPA-administered program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... administered by EPA. (The term “Indian lands” is defined at 40 CFR 144.3.) The Navajo Indian lands are in the.... The UIC program for Navajo Indian lands, except for Class II wells on Navajo Indian lands for which..., except for Class II wells on Navajo Indian lands for which EPA has granted the Navajo Nation primacy......

  14. 40 CFR 147.151 - EPA-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Navajo Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted... administered by EPA. The UIC program for Navajo Indian lands, except for Class II wells on Navajo Indian......

  15. 40 CFR 147.151 - EPA-administered program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Navajo Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted... administered by EPA. The UIC program for Navajo Indian lands, except for Class II wells on Navajo Indian......

  16. 40 CFR 147.151 - EPA-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Navajo Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted... administered by EPA. The UIC program for Navajo Indian lands, except for Class II wells on Navajo Indian......

  17. 40 CFR 147.151 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Navajo Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted... administered by EPA. The UIC program for Navajo Indian lands, except for Class II wells on Navajo Indian......

  18. 32 CFR 637.11 - Authority to administer oaths.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Authority to administer oaths. 637.11 Section 637.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.11 Authority...

  19. 32 CFR 637.11 - Authority to administer oaths.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Authority to administer oaths. 637.11 Section 637.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.11 Authority...

  20. 32 CFR 637.11 - Authority to administer oaths.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Authority to administer oaths. 637.11 Section 637.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.11 Authority...

  1. 32 CFR 637.11 - Authority to administer oaths.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Authority to administer oaths. 637.11 Section 637.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.11 Authority...

  2. 32 CFR 637.11 - Authority to administer oaths.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Authority to administer oaths. 637.11 Section 637.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.11 Authority...

  3. 40 CFR 147.1450 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be... of Nevada, other than those on Indian lands, is the program administered by the Nevada Division of... Protection Agency, Region IX, 215 Fremont Street, San Francisco, California 99105, or at the...

  4. Teaching Auction Strategy Using Experiments Administered Via the Internet

    ERIC Educational Resources Information Center

    Asker, John; Grosskopf, Brit; McKinney, C. Nicholas; Niederle, Muriel; Roth, Alvin E.; Weizsacker, Georg

    2004-01-01

    The authors present an experimental design used to teach concepts in the economics of auctions and implications for e-Business procurement. The experiment is easily administered and can be adapted to many different treatments. The chief innovation is that it does not require the use of a lab or class time. Instead, the design can be implemented on…

  5. 40 CFR 147.1300 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. 147.1300...) Opinion Letter No. 63 and attached Memorandum Opinion, signed by Attorney General of Missouri, March 16, 1982; (2) Addendum to Opinion Letter No. 63 (1982), signed by Attorney General of Missouri, October...

  6. Evaluation of coagulation via thromboelastography in healthy horses administered dexamethasone

    PubMed Central

    Woodman, Jenna; Wagg, Catherine R.; Boysen, Søren R.; Leguillette, Renaud; Mizen, Kyle; Roy, Marie-France

    2015-01-01

    Dexamethasone was administered to healthy horses daily for 7 days. Blood samples were collected at 3 time points from both treatment and non-treatment groups, and analyzed via thromboelastography (TEG). There were no significant differences in TEG parameters between treated and untreated horses, or within treatment groups over time. PMID:26677262

  7. 8 CFR 337.8 - Oath administered by the courts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... naturalization not subject to the exclusive jurisdiction of 8 CFR 310.2(d) must notify USCIS at the time of the... from the list of eligible persons as provided in 8 CFR 335.5 and the court will not administer the oath... naturalization not subject to the exclusive jurisdiction of 8 CFR 310.3(d) who has elected to have......

  8. 40 CFR 147.950 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Drilling Mud and Salt Water Generated from Drilling and Production of Oil and Gas Wells..., 1985 and January 20, 1986; (3)(i) Statewide Order Governing the Drilling for and Producing of Oil and... State-administered program. The UIC program for Class I, II, III, IV, and V wells in the State...

  9. Molecular Mechanisms of Taste Disorder in Oxaliplatin-administered Rats.

    PubMed

    Nishida, Kentaro

    2016-01-01

    Taste disorder is one of the adverse effects of cancer chemotherapy resulting in a loss of appetite, leading to malnutrition and a decrease in the quality of life of the patient. Oxaliplatin, a platinum anticancer drug, has a critical role in colon cancer chemotherapy and is known to induce taste disorder. Here, we evaluated the taste functions in oxaliplatin-administered rats. Among the taste receptors, expression levels of T1R2, one of the sweet receptor subunits, increased in the circumvallate papillae of the oxaliplatin-administered rats. In a brief-access test, i.e., behavioral analysis of the taste response, oxaliplatin-administered rats showed a decreased response to sweet taste. However, we did not detect any differences in the plasma levels of zinc, number of taste cells, or morphology of taste buds between control and oxaliplatin-administered rats. In conclusion, the decreased response to sweet taste by oxaliplatin administration may be due to the upregulation of T1R2 expression. PMID:27374965

  10. 40 CFR 147.151 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona § 147.151 EPA... the Navajo Nation primacy for the SDWA Class II UIC program (as defined in § 147.3400), is... for which EPA has granted the Navajo Nation primacy for the SDWA Class II UIC program, consists of...

  11. 40 CFR 147.1700 - State-administered program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... incorporation by reference was approved by the Director of the OFR in accordance with 5 U.S.C. 552(a) and 1 CFR...-administered program: (1) N.C. ADMIN. CODE, Title 15, r. 02L.0100 et seq. Groundwater Classification...

  12. 40 CFR 147.1700 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... incorporation by reference was approved by the Director of the OFR in accordance with 5 U.S.C. 552(a) and 1 CFR...-administered program: (1) N.C. ADMIN. CODE, Title 15, r. 02L.0100 et seq. Groundwater Classification...

  13. 40 CFR 147.1700 - State-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... incorporation by reference was approved by the Director of the OFR in accordance with 5 U.S.C. 552(a) and 1 CFR...-administered program: (1) N.C. ADMIN. CODE, Title 15, r. 02L.0100 et seq. Groundwater Classification...

  14. 40 CFR 147.2500 - State-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... reference was approved by the Director of the OFR in accordance with 5 U.S.C. 552(a) and 1 CFR part 51... Disposal of Liquid Industrial Wastes and By-Products, Wisconsin Administrative Code §§ 214.03 and 214.08... State-administered program: (1) Chapter 144, Water, Sewage, Refuse, Mining and Air Pollution,...

  15. Systemically Administered, Target Organ-Specific Therapies for Regenerative Medicine

    PubMed Central

    Järvinen, Tero A. H.; May, Ulrike; Prince, Stuart

    2015-01-01

    Growth factors and other agents that could potentially enhance tissue regeneration have been identified, but their therapeutic value in clinical medicine has been limited for reasons such as difficulty to maintain bioactivity of locally applied therapeutics in the protease-rich environment of regenerating tissues. Although human diseases are treated with systemically administered drugs in general, all current efforts aimed at enhancing tissue repair with biological drugs have been based on their local application. The systemic administration of growth factors has been ruled out due to concerns about their safety. These concerns are warranted. In addition, only a small proportion of systemically administered drugs reach their intended target. Selective delivery of the drug to the target tissue and use of functional protein domains capable of penetrating cells and tissues could alleviate these problems in certain circumstances. We will present in this review a novel approach utilizing unique molecular fingerprints (“Zip/postal codes”) in the vasculature of regenerating tissues that allows target organ-specific delivery of systemically administered therapeutic molecules by affinity-based physical targeting (using peptides or antibodies as an “address tag”) to injured tissues undergoing repair. The desired outcome of targeted therapies is increased local accumulation and lower systemic concentration of the therapeutic payload. We believe that the physical targeting of systemically administered therapeutic molecules could be rapidly adapted in the field of regenerative medicine. PMID:26437400

  16. Intravenously administered nanoparticles increase survival following blast trauma

    PubMed Central

    Lashof-Sullivan, Margaret M.; Shoffstall, Erin; Atkins, Kristyn T.; Keane, Nickolas; Bir, Cynthia; VandeVord, Pamela; Lavik, Erin B.

    2014-01-01

    Explosions account for 79% of combat-related injuries, leading to multiorgan hemorrhage and uncontrolled bleeding. Uncontrolled bleeding is the leading cause of death in battlefield traumas as well as in civilian life. We need to stop the bleeding quickly to save lives, but, shockingly, there are no treatments to stop internal bleeding. A therapy that halts bleeding in a site-specific manner and is safe, stable at room temperature, and easily administered is critical for the advancement of trauma care. To address this need, we have developed hemostatic nanoparticles that are administered intravenously. When tested in a model of blast trauma with multiorgan hemorrhaging, i.v. administration of the hemostatic nanoparticles led to a significant improvement in survival over the short term (1 h postblast). No complications from this treatment were apparent out to 3 wk. This work demonstrates that these particles have the potential to save lives and fundamentally change trauma care. PMID:24982180

  17. Analgesic efficacy of orally administered buprenorphine in rats.

    PubMed

    Martin, L B; Thompson, A C; Martin, T; Kristal, M B

    2001-02-01

    The analgesic effect of orally administered buprenorphine was compared with that induced by a standard therapeutic injected dose (0.05 mg/kg of body weight, s.c.) in male Long-Evans rats. Analgesia was assessed by measuring pain threshold, using the hot-water tail-flick assay before and after administration of buprenorphine. The results suggest that a commonly used formula for oral buprenorphine in flavored gelatin, at a dose of 0.5 mg/kg, does not increase pain threshold in rats. Instead, oral buprenorphine doses of 5 and 10 mg/kg were necessary to induce significant increases in pain threshold. However, these doses had to be administered by orogastric infusion because the rats would not voluntarily eat flavored gelatin containing this much buprenorphine. The depth of analgesia induced by these infused doses was comparable to that induced by the clinically effective s.c. treatment (0.05 mg/kg).

  18. 40 CFR 282.69 - Maine State-Administered Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Maine obtains approval for the... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Maine..., 7003, 9005 and 9006 of RCRA, 42 U.S.C. 6927, 6973, 6991d and 6991e, as well as under other...

  19. 40 CFR 282.69 - Maine State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Maine obtains approval for the... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Maine..., 7003, 9005 and 9006 of RCRA, 42 U.S.C. 6927, 6973, 6991d and 6991e, as well as under other...

  20. 40 CFR 282.69 - Maine State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Maine obtains approval for the... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Maine..., 7003, 9005 and 9006 of RCRA, 42 U.S.C. 6927, 6973, 6991d and 6991e, as well as under other...

  1. 40 CFR 282.69 - Maine State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Maine obtains approval for the... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Maine..., 7003, 9005 and 9006 of RCRA, 42 U.S.C. 6927, 6973, 6991d and 6991e, as well as under other...

  2. 40 CFR 282.69 - Maine State-Administered Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If Maine obtains approval for the... 1976 (RCRA), as amended, 42 U.S.C. 6991 et seq. The State's program, as administered by the Maine..., 7003, 9005 and 9006 of RCRA, 42 U.S.C. 6927, 6973, 6991d and 6991e, as well as under other...

  3. Nursing takes time: workload associated with administering cancer protocols.

    PubMed

    de Raad, Johan; van Gool, Kees; Haas, Marion; Haywood, Philip; Faedo, Margaret; Gallego, Gisselle; Pearson, Sallie; Ward, Robyn

    2010-12-01

    New medicines and therapeutic combinations are tested and marketed every year. Healthcare decision makers have to make explicit choices about adopting new treatments and deal with the resource consequences of their choices. The aim of this article is to examine the nursing workload of administering alternative chemotherapy protocols as a driver of costs. Data collection (focus groups with chemotherapy nurses and a survey of nurse unit managers) was conducted to ascertain the time required to undertake chemotherapy-related tasks and the sources of variability in six chemotherapy centers in New South Wales, Australia. Four task types (patient education, patient assessment, administration, and patient communication) were identified as being associated with administering chemotherapy. On average, patient education required 48 minutes during the first visit and 18.5 minutes thereafter, patient assessment took 20.3 minutes, administration averaged 23 minutes, and patient communication required 24.2 minutes. Each center treated an average of 14 patients per day. Each patient received 3.3 hours of staff time (1.7 hours of direct contact time and 1.6 hours of noncontact time). The result of this research will allow healthcare decision makers and evaluators to predict the amount of nursing time required to administer chemotherapy based on the characteristics of a wide range of chemotherapy protocols.

  4. Pharmacokinetics of tetraplatin administered intraperitoneally with reduced glutathione in mice.

    PubMed

    Kido, Y; Khokhar, A R; Yoshida, M; Thai, G W; Siddik, Z H

    1994-01-01

    Tetraplatin (Ormaplatin) has been developed as a second generation platinum complex because of its good antitumor activity against some cisplatin-resistant tumor cell lines. It is currently in clinical trials. Its reduction to diaminocyclohexane (DACH)-dichloroplatinum(II) [DACH-Pt(II)Cl2] or closely similar species is essential for binding to DNA to produce the desired antitumor effects. We have studied the pharmacokinetics of tetraplatin in mice after intraperitoneal administration with the reducing agent glutathione (GSH). The systemic absorption of tetraplatin (5 mg/kg) with GSH (31 mg/kg) was faster than of tetraplatin alone. Peak plasma platinum (Pt) levels of 0.89 and 1.44 micrograms Pt/ml were observed at 15 min and 2 hr after administration of tetraplatin with and without GSH, respectively, and the Pt then decayed biphasically when administered with GSH and monophasically when administered alone. The plasma Pt level was 4-fold lower (0.17 vs. 0.71 micrograms Pt/ml) by 24 hr when tetraplatin was administered with GSH compared with its administration alone. DACH-Pt(II)Cl2 (4.21 mg/kg, ip) gave similar plasma Pt kinetics to that seen with the combination of tetraplatin and GSH. Pt levels in kidney 24 hr after administration of tetraplatin+GSH or of DACH-Pt(II)Cl2 were lower (1.6-fold) than after tetraplatin alone. Plasma and ascitic fluid from tumor-bearing mice demonstrated equivalent abilities to reduce tetraplatin rapidly. However, tetraplatin treatment of intraperitoneal-inoculated L1210/0 (parent) or L1210/DDP (cisplatin-resistant) tumor cells was unaffected by GSH. As GSH lowered systemic tetraplatin exposure in vivo without compromising antitumor activity against peritoneal tumor models, the combination of thiol and tetraplatin may be clinically useful in the treatment of intraperitoneal disseminated cancers. PMID:8013287

  5. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A; Miller, Douglas R

    2014-03-18

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  6. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A; Miller, Douglas R

    2012-10-23

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  7. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A.; Miller, Douglas R.

    2013-01-01

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  8. Absorption and distribution of orally administered jojoba wax in mice.

    PubMed

    Yaron, A; Samoiloff, V; Benzioni, A

    1982-03-01

    The liquid wax obtained from the seeds of the arid-land shrub jojoba (Simmondsia chinensis) is finding increasing use in skin treatment preparations. The fate of this wax upon reaching the digestive tract was studied. 14C-Labeled wax was administered intragastrically to mice, and the distribution of the label in the body was determined as a function of time. Most of the wax was excreted, but a small amount was absorbed, as was indicated by the distribution of label in the internal organs and the epididymal fat. The label was incorporated into the body lipids and was found to diminish with time.

  9. Comparison of Interviewer-Administered and Automated Self-Administered 24-Hour Dietary Recalls in 3 Diverse Integrated Health Systems.

    PubMed

    Thompson, Frances E; Dixit-Joshi, Sujata; Potischman, Nancy; Dodd, Kevin W; Kirkpatrick, Sharon I; Kushi, Lawrence H; Alexander, Gwen L; Coleman, Laura A; Zimmerman, Thea P; Sundaram, Maria E; Clancy, Heather A; Groesbeck, Michelle; Douglass, Deirdre; George, Stephanie M; Schap, TusaRebecca E; Subar, Amy F

    2015-06-15

    Twenty-four-hour dietary recalls provide high-quality intake data but have been prohibitively expensive for large epidemiologic studies. This study's goal was to assess whether the web-based Automated Self-Administered 24-Hour Recall (ASA24) performs similarly enough to the standard interviewer-administered, Automated Multiple-Pass Method (AMPM) 24-hour dietary recall to be considered a viable alternative. In 2010-2011, 1,081 adults from 3 integrated health systems in Detroit, Michigan; Marshfield, Wisconsin; and Kaiser-Permanente Northern California participated in a field trial. A quota design ensured a diverse sample by sex, age, and race/ethnicity. Each participant was asked to complete 2 recalls and was randomly assigned to 1 of 4 protocols differing by type of recall and administration order. For energy, the mean intakes were 2,425 versus 2,374 kcal for men and 1,876 versus 1,906 kcal for women by AMPM and ASA24, respectively. Of 20 nutrients/food groups analyzed and controlling for false discovery rate, 87% were judged equivalent at the 20% bound. ASA24 was preferred over AMPM by 70% of the respondents. Attrition was lower in the ASA24/AMPM study group than in the AMPM/ASA24 group, and it was lower in the ASA24/ASA24 group than in the AMPM/AMPM group. ASA24 offers the potential to collect high-quality dietary intake information at low cost with less attrition.

  10. Administering truncated receive functions in a parallel messaging interface

    DOEpatents

    Archer, Charles J; Blocksome, Michael A; Ratterman, Joseph D; Smith, Brian E

    2014-12-09

    Administering truncated receive functions in a parallel messaging interface (`PMI`) of a parallel computer comprising a plurality of compute nodes coupled for data communications through the PMI and through a data communications network, including: sending, through the PMI on a source compute node, a quantity of data from the source compute node to a destination compute node; specifying, by an application on the destination compute node, a portion of the quantity of data to be received by the application on the destination compute node and a portion of the quantity of data to be discarded; receiving, by the PMI on the destination compute node, all of the quantity of data; providing, by the PMI on the destination compute node to the application on the destination compute node, only the portion of the quantity of data to be received by the application; and discarding, by the PMI on the destination compute node, the portion of the quantity of data to be discarded.

  11. Analgesic and cardiovascular effects of centrally administered substance P.

    PubMed

    Clint, B D; Lipton, J M; Giesecke, A H

    1988-01-01

    Substance P (SP) injected intracerebroventricularly (ICV) into rabbits caused dose-related thermal analgesia with the maximum effect after 2 micrograms. The analgesia was measured by timing the withdrawal of the rabbit's ear from an infrared beam. Equimolar amounts of the related peptides physalaemin and eledoisin-related peptide also caused analgesia, but the SP N-terminal fragment (1-9) was inactive. This suggests that the analgesic message of SP resides within the C-terminal fragment. The analgesia caused by each peptide developed more rapidly but did not last as long as that after central injection of beta-endorphin. In separate experiments, 2 micrograms SP injected ICV increased blood pressure and decreased heart rate. The analgesic, bradycardic and pressor responses to central administration of SP were opposite to effects of peripherally administered SP, described previously. These results indicate that the effect induced by SP depends upon its specific neuroanatomical site of action.

  12. [Spontaneous reporting system data analysis of parenterally administered Shenmai].

    PubMed

    Wang, Lian-Xin; Xiang, Yong-Yang; Xie, Yan-Ming; Shen, Hao; Ai, Qing-Hua

    2013-09-01

    Spontaneous reporting system (SRS) datais currently an important source of monitoring and finding ADRs signals throughout the world. This method can promptly and effectively discover ADR signals, thus preventing and avoiding ADRs effectively. Parenterally administered Shenmai has the functions of benefiting vital energy, nourishing Yin and generating body fluids, and activating the pulse. Clinically it is used in various diseases including shock, coronary heart disease, viral myocarditis, chronic pulmonary heart disease, and granulocytopenia. The large, national SRS database of ADRs needs effective evaluation methods. We report on the use of Bayesian confidence propagation neural network method (BCPNN) and proportional reporting ration (PRR) with propensity score to control for confounding variables. Early warning signs of an ADR are, a feeling of suffocation (difficulty exhaling), anaphylactoid reactions and flushing. Furthermore, relevant relationships between the different factors is analysed by association rules (AR). It is found that there is a close relationship between past history of ADRs, a family history of ADRs and itching. PMID:24471317

  13. Human metabolism of orally administered radioactive cobalt chloride.

    PubMed

    Holstein, H; Ranebo, Y; Rääf, C L

    2015-05-01

    This study investigated the human gastrointestinal uptake (f1) and subsequent whole-body retention of orally administered inorganic radioactive cobalt. Of eight adult volunteers aged between 24 and 68 years, seven were given solutions of (57)Co (T1/2 = 272 d) containing a stable cobalt carrier, and six were given carrier-free (58)Co (T1/2 = 71 d). The administered activities ranged between 25 and 103 kBq. The observed mean f1, based on 6 days accumulated urinary excretion sampling and whole-body counting, was 0.028 ± 0.0048 for carrier-free (58)Co, and 0.016 ± 0.0021 for carrier-associated (57)Co. These values were in reasonable agreement with values reported from previous studies involving a single intake of inorganic cobalt. The time pattern of the total retention (including residual cobalt in the GI tract) included a short-term component with a biological half-time of 0.71 ± 0.03 d (average ± 1 standard error of the mean for the two nuclides), an intermediate component with a mean half-time of 32 ± 8.5 d, and a long-term component (observed in two volunteers) with half-times ranging from 80 to 720 d for the two isotopes. From the present data we conclude that for the short-lived (57)Co and (58)Co, more than 95% of the internal absorbed dose was delivered within 7 days following oral intake, with a high individual variation influenced by the transit time of the unabsorbed cobalt through the gastro-intestinal tract.

  14. Opponent process properties of self-administered cocaine.

    PubMed

    Ettenberg, Aaron

    2004-01-01

    Over the past decade, data collected in our laboratory have demonstrated that self-administered cocaine produces Opponent-Process-like behavioral effects. Animals running a straight alley once each day for IV cocaine develop over trials an approach-avoidance conflict about re-entering the goal box. This conflict behavior is characterized by a stop in forward locomotion (usually at the very mouth of the goal box) followed by a turn and 'retreat' back toward the goal box. The results of a series of studies conducted over the past decade collectively suggest that the behavioral ambivalence exemplified by rats running the alley for IV cocaine stems from concurrent and opponent positive (rewarding) and negative (anxiogenic) properties of the drug--both of which are associated with the goal box. These opponent properties of cocaine have been shown to result from temporally distinct affective states. Using a conditioned place preference test, we have been able to demonstrate that while the initial immediate effects of IV cocaine are reinforcing, the state present 15 min post-injection is aversive. In our most recent work, the co-administration of IV cocaine with either oral ethanol or IV heroin was found to greatly diminish the development and occurrence of retreat behaviors in the runway. It may therefore be that the high incidence of co-abuse of cocaine with either ethanol or heroin, stems from the users' motivation to alleviate some of the negative side effects of cocaine. It would seem then that the Opponent Process Theory has provided a useful conceptual framework for the study of the behavioral consequences of self-administered cocaine including the notion that both positive and negative reinforcement mechanisms are involved in the development and maintenance of cocaine abuse.

  15. Safety of florfenicol administered in feed to tilapia (Oreochromis sp.)

    USGS Publications Warehouse

    Gaikowski, Mark P.; Wolf, Jeffrey C.; Schleis, Susan M.; Tuomari, Darrell; Endris, Richard G.

    2013-01-01

    The safety of Aquaflor® (50% w/w florfenicol [FFC]) incorporated in feed then administered to tilapia for 20 days (2x the recommended duration) at 0, 15, 45, or 75 mg/kg body weight/day (0, 1, 3, or 5x the recommended dose of 15 mg FFC/kg BW/d) was investigated. Mortality, behavioral change, feed consumption, body size, and gross and microscopic lesions were determined. Estimated delivered doses were >96.9% of target. Three unscheduled mortalities occurred but were considered incidental since FFC-related findings were not identified. Feed consumption was only affected during the last 10 dosing days when the 45 and 75 mg/kg groups consumed only 62.5% and 55.3% of the feed offered, respectively. There were significant, dose-dependent reductions in body size in the FFC-dose groups relative to the controls. Treatment-related histopathological findings included increased severity of lamellar epithelial hyperplasia, increased incidence of lamellar adhesions, decreased incidence of lamellar telangiectasis in the gills, increased glycogen-type and lipid-type hepatocellular vacuolation in the liver, decreased lymphocytes, increased blast cells, and increased individual cell necrosis in the anterior kidney, and tubular epithelial degeneration and mineralization in the posterior kidney. These changes are likely to be of minimal clinical relevance, given the lack of mortality or morbidity observed. This study has shown that FFC, when administered in feed to tilapia at the recommended dose (15 mg FFC/kg BW/day) for 10 days would be well tolerated.

  16. Opponent process properties of self-administered cocaine.

    PubMed

    Ettenberg, Aaron

    2004-01-01

    Over the past decade, data collected in our laboratory have demonstrated that self-administered cocaine produces Opponent-Process-like behavioral effects. Animals running a straight alley once each day for IV cocaine develop over trials an approach-avoidance conflict about re-entering the goal box. This conflict behavior is characterized by a stop in forward locomotion (usually at the very mouth of the goal box) followed by a turn and 'retreat' back toward the goal box. The results of a series of studies conducted over the past decade collectively suggest that the behavioral ambivalence exemplified by rats running the alley for IV cocaine stems from concurrent and opponent positive (rewarding) and negative (anxiogenic) properties of the drug--both of which are associated with the goal box. These opponent properties of cocaine have been shown to result from temporally distinct affective states. Using a conditioned place preference test, we have been able to demonstrate that while the initial immediate effects of IV cocaine are reinforcing, the state present 15 min post-injection is aversive. In our most recent work, the co-administration of IV cocaine with either oral ethanol or IV heroin was found to greatly diminish the development and occurrence of retreat behaviors in the runway. It may therefore be that the high incidence of co-abuse of cocaine with either ethanol or heroin, stems from the users' motivation to alleviate some of the negative side effects of cocaine. It would seem then that the Opponent Process Theory has provided a useful conceptual framework for the study of the behavioral consequences of self-administered cocaine including the notion that both positive and negative reinforcement mechanisms are involved in the development and maintenance of cocaine abuse. PMID:15019422

  17. Evaluation of a Self-Administered Oral Glucose Tolerance Test

    PubMed Central

    Bethel, M. Angelyn; Price, Hermione C.; Sourij, Harald; White, Sarah; Coleman, Ruth L.; Ring, Arne; Kennedy, Irene E.C.; Tucker, Lynne; Holman, Rury R.

    2013-01-01

    OBJECTIVE To assess the feasibility of using a disposable, self-administered, capillary blood sampling oral glucose tolerance test (OGTT) device in a community setting. RESEARCH DESIGN AND METHODS Eighteen healthy and 12 type 2 diabetic volunteers underwent six 75-g OGTTs using a prototype device in the following three settings: unaided at home (twice); unaided but observed in clinic (twice); and performed by a nurse with simultaneous laboratory glucose assays of 0- and 120-min venous plasma samples (twice). The device displayed no results. A detachable data recorder returned to the clinic provided plasma-equivalent 0- and 120-min glucose values and key parameters, including test date, start and end times, and time taken to consume the glucose drink. RESULTS The device was universally popular with participants and was perceived as easy to use, and the ability to test at home was well liked. Device failures meant that 0- and 120-min glucose values were obtained for only 141 (78%) of the 180 OGTTs performed, independent of setting. Device glucose measurements showed a mean bias compared with laboratory-measured values of +0.9 at 5.0 mmol/L increasing to +4.4 at 15.0 mmol/L. Paired device glucose values were equally reproducible across settings, with repeat testing showing no training effect regardless of setting order. CONCLUSIONS Self-administered OGTTs can be performed successfully by untrained individuals in a community setting. With improved device reliability and appropriate calibration, this novel technology could be used in routine practice to screen people who might need a formal OGTT to confirm the presence of impaired glucose tolerance or diabetes. PMID:23321216

  18. Psychoactive natural products: overview of recent developments.

    PubMed

    Ujváry, István

    2014-01-01

    Natural psychoactive substances have fascinated the curious mind of shamans, artists, scholars and laymen since antiquity. During the twentieth century, the chemical composition of the most important psychoactive drugs, that is opium, cannabis, coca and "magic mushrooms", has been fully elucidated. The mode of action of the principal ingredients has also been deciphered at the molecular level. In the past two decades, the use of herbal drugs, such as kava, kratom and Salvia divinorum, began to spread beyond their traditional geographical and cultural boundaries. The aim of the present paper is to briefly summarize recent findings on the psychopharmacology of the most prominent psychoactive natural products. Current knowledge on a few lesser-known drugs, including bufotenine, glaucine, kava, betel, pituri, lettuce opium and kanna is also reviewed. In addition, selected cases of alleged natural (or semi-natural) products are also mentioned. PMID:24695249

  19. Synergy and other interactions in phytomedicines.

    PubMed

    Williamson, E M

    2001-09-01

    Synergistic interactions are of vital importance in phytomedicines, to explain difficulties in always isolating a single active ingredient, and explain the efficacy of apparently low doses of active constituents in a herbal product. This concept, that a whole or partially purified extract of a plant offers advantages over a single isolated ingredient, also underpins the philosophy of herbal medicine. Evidence to support the occurrence of synergy in within phytomedicines is now accumulating and is reviewed here. Synergistic interactions are documented for constituents within a total extract of a single herb, as well as between different herbs in a formulation. Positive and negative aspects of interactions are discussed together with the methods used to identify and measure synergy. The evidence is divided into experimental, in vitro instances, as well as clinical examples where available. Herbs discussed include Ginkgo biloba, Piper methysticum (Kava-Kava), Glycyrrhiza glabra, Hypericum perforatum, Valeriana officinalis, Cannabis sativa, Salix alba and others.

  20. Phytomedicine research in Germany.

    PubMed Central

    Wagner, H

    1999-01-01

    In Germany since 1980, more than 300 clinical studies have been carried out with standardized phytopharmaceuticals, including Crataegus, Silybum, Ginkgo, Hypericum, Sabal, Urtica, Kava-Kava, Allium sativum, Valeriana, Aesculus, Echinacea, and Viscum drugs. These studies assessed the efficacy of phytopharmaceuticals for the treatment of moderate or moderately severe diseases and prevention. Several comparative clinical trials showed that these phytopharmaceuticals had full therapeutic equivalence with chemotherapeutics and had the simultaneous advantage of being devoid of any adverse effects. The mechanism of action of herbal drugs and their extract preparations, which differ in many respects from that of synthetic drugs or mono substances, can be characterized as a polyvalent action and interpreted as additive or, in some cases, potentiating. Currently, a rationale for the observed reversal effects and optimal effects with very low doses after a long-term application has not been developed, but is under investigation by systematic research at the molecular level. PMID:10504142

  1. 40 CFR 147.1852 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Oklahoma... lands in Oklahoma, except Class II wells on the lands of the Five Civilized Tribes, is administered...

  2. 43 CFR 420.25 - Reclamation lands administered by other agencies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... RECLAMATION, DEPARTMENT OF THE INTERIOR OFF-ROAD VEHICLE USE Designated Areas and Permitted Events § 420.25 Reclamation lands administered by other agencies. (a) Off-road vehicle use will be administered in...

  3. Administering and Detecting Protein Marks on Arthropods for Dispersal Research.

    PubMed

    Hagler, James R; Machtley, Scott A

    2016-01-28

    Monitoring arthropod movement is often required to better understand associated population dynamics, dispersal patterns, host plant preferences, and other ecological interactions. Arthropods are usually tracked in nature by tagging them with a unique mark and then re-collecting them over time and space to determine their dispersal capabilities. In addition to actual physical tags, such as colored dust or paint, various types of proteins have proven very effective for marking arthropods for ecological research. Proteins can be administered internally and/or externally. The proteins can then be detected on recaptured arthropods with a protein-specific enzyme-linked immunosorbent assay (ELISA). Here we describe protocols for externally and internally tagging arthropods with protein. Two simple experimental examples are demonstrated: (1) an internal protein mark introduced to an insect by providing a protein-enriched diet and (2) an external protein mark topically applied to an insect using a medical nebulizer. We then relate a step-by-step guide of the sandwich and indirect ELISA methods used to detect protein marks on the insects. In this demonstration, various aspects of the acquisition and detection of protein markers on arthropods for mark-release-recapture, mark-capture, and self-mark-capture types of research are discussed, along with the various ways that the immunomarking procedure has been adapted to suit a wide variety of research objectives.

  4. A non-specific effect of orally administered Escherichia coli.

    PubMed

    Gardlik, Roman

    2011-01-01

    A number of genetically modified bacteria able to deliver a therapeutic gene into target cells has already been tested. Apart from the expected effects of bacterial therapy, the therapeutic bacterial strain also mediates a non-specific effect independent of the gene to be delivered. In this regard, we have recently shown that oral administration of the bacterial strain Escherichia coli XL1-Blue via gastric gavage to rats leads to a non-specific decrease in expression of vascular endothelial growth factor (VEGF) in intestinal wall without corresponding changes in other parameters. We tried to adopt a model of intestinal ischemia and to treat the subsequent hypoxic condition using a strain carrying the effector plasmid encoding hypoxia-inducible factor 1 alpha (HIF-1alpha), as well as the helper plasmid encoding invasion and listeriolysin O. However, the model was ineffective, as obvious from macroscopic and molecular observations. We hypothesize that a competitive behavior of the administered strain in the intestinal microbiota leads to a decrease in activity of HIF-1alpha and reduction in expression of VEGF. Also, a functional disease model would be necessary for the invasion-expressing therapeutic strain to be effective. A different approach using bacterial protein delivery would possibly circumvent these bactofection-related problems.

  5. Hemodynamic effects of centrally administered, norcocaine in the rat.

    PubMed

    Barber, D A; Tackett, R L

    1992-01-01

    Norcocaine is the N-demethylated metabolite of cocaine. It is present in the CNS and is reported to be pharmacologically active. The present study was designed to evaluate the cardiovascular actions of norcocaine following central administration. Wistar Kyoto (WKY) rats were anesthetized with pentobarbital and instrumented for measurement of blood pressure and renal and hindlimb blood flow (via Doppler flowprobes). A cerebroventricular cannula was placed in the lateral ventricle for drug administration. Cocaine or norcocaine was administered centrally in a dose range of 0.025 to 4.0 mg/kg. Under the above experimental conditions, 4.0 mg/kg of norcocaine decreased blood pressure without a significant change in either hind limb or renal blood flow. Central administration of cocaine also produced a similar depressor response. In conscious, unrestrained rats, cocaine produced a pressor response while norcocaine did not significantly alter blood pressure. The depressor response to both cocaine and norcocaine in the anesthetized animal is speculated to be due to the local anesthetic properties of the drugs.

  6. Inducing and Administering Tregs to Treat Human Disease

    PubMed Central

    Perdigoto, Ana Luisa; Chatenoud, Lucienne; Bluestone, Jeffrey A.; Herold, Kevan C.

    2016-01-01

    Regulatory T cells (Tregs) control unwanted immune responses, including those that mediate tolerance to self as well as to foreign antigens. Their mechanisms of action include direct and indirect effects on effector T cells and important functions in tissue repair and homeostasis. Tregs express a number of cell surface markers and transcriptional factors that have been instrumental in defining their origins and potentially their function. A number of immune therapies, such as rapamycin, IL-2, and anti-T cell antibodies, are able to induce Tregs and are being tested for their efficacy in diverse clinical settings with exciting preliminary results. However, a balance exists with the use of some, such as IL-2, that may have effects on unwanted populations as well as promoting expansion and survival of Tregs requiring careful selection of dose for clinical use. The use of cell surface markers has enabled investigators to isolate and expand ex vivo Tregs more than 500-fold routinely. Clinical trials have begun, administering these expanded Tregs to patients as a means of suppressing autoimmune and alloimmune responses and potentially inducing immune tolerance. Studies in the future are likely to build on these initial technical achievements and use combinations of agents to improve the survival and functional capacity of Tregs. PMID:26834735

  7. Absorption Kinetics of Subcutaneously Administered Ceftazidime in Hypoperfused Guinea Pigs

    PubMed Central

    Ebihara, Tsuyoshi; Oshima, Shinji; Okita, Mitsuyoshi; Shiina, Sayumi; Negishi, Akio; Ohara, Kousuke; Ohshima, Shigeru; Iwasaki, Hiroyuki; Yoneyama, Akira; Kitazumi, Eiji; Kobayashi, Daisuke

    2014-01-01

    Background Pneumonia is the most common cause of death in patients with severe motor and intellectual disabilities (SMID), and intravenous ceftazidime (CAZ) is a widely used treatment for such infections. However, intravenous administration in patients with SMID may be difficult because of insufficient vascular development. Objectives The aim of our study was to determine the feasibility of subcutaneous drug administration by mentholated warm compresses (WMCs) as an alternative delivery method for ceftazidime in patients with SMID. Methods CAZ was subcutaneously administered to the abdominal region of naphazoline-treated hypoperfused guinea pigs, which were used as a hemodynamic model of patients with SMID. MWCs or warm compresses (WCs) were applied to the injection site to increase blood flow. We calculated the cumulative CAZ absorption over time by using the deconvolution method. Results Application of MWCs or WCs increased blood flow at the administration site and increased CAZ plasma levels. Application of MWCs or WCs after subcutaneous CAZ injection led to higher CAZ plasma levels than the mutant prevention concentration for a longer period than was observed for CAZ administration without the application of MWCs or WCs. Conclusions The application of MWCs or WCs enhanced subcutaneous CAZ absorption by increasing blood flow. MWCs and WCs are considered to be safe and routine methods to induce defecation after surgery on the digestive system; thus, the combination of these methods and subcutaneous CAZ administration is a potential method for treating pneumonia in patients with SMID. PMID:26649076

  8. Experiences of administering and receiving therapeutic touch in intensive care.

    PubMed

    Cox, C; Hayes, J

    1998-10-01

    This article describes the experiences of a practitioner who administered therapeutic touch (TT) to two patients in an intensive care unit and the experiences of the two patients who received TT. The experiences are presented as two case studies. Each of the patients presented in the case studies received either five or ten treatments of TT lasting five minutes each. Following each administration of TT the practitioner described what she sensed verbally and in writing. However, owing to the medical conditions of the patients, only brief interviews were conducted in which the patients were asked to describe their experiences of receiving TT. The experiences, which have been reflected in the case studies, indicate TT assists patients to relax, brings comfort and a sense of peace. Much like meditation, TT helps patients become more in touch with themselves. They come to understand more about themselves and reality. TT is recommended as a practice which could contribute to the psychological well-being of patients in intensive care as it promotes relaxation, comfort and a sense of peace.

  9. Nicotine elicits methamphetamine-seeking in rats previously administered nicotine.

    PubMed

    Neugebauer, N M; Harrod, S B; Bardo, M T

    2010-01-01

    Research has indicated a high correlation between psychostimulant use and tobacco cigarette smoking in human substance abusers. The objective of the current study was to examine the effects of acute and repeated nicotine administration on responding for intravenous methamphetamine (0.03 mg/kg/infusion) in a rodent model of self-administration, as well as the potential of nicotine to induce reinstatement of previously extinguished drug-taking behavior in male Sprague-Dawley rats. In addition, it was assessed whether nicotine-induced reinstatement of methamphetamine-seeking behavior and nicotine-induced locomotor sensitization require that nicotine be temporally paired with the methamphetamine self-administration session or the locomotor activity chamber. Nicotine acutely decreased methamphetamine self-administration, but did not persistently alter responding during the maintenance of methamphetamine self-administration. However, following extinction of methamphetamine self-administration, nicotine administration reinstated methamphetamine-seeking behavior only in rats that had previously been administered nicotine. Nicotine-induced reinstatement and expression of locomotor sensitization were not dependent on a temporal pairing of nicotine with either the methamphetamine self-administration session or the locomotor activity chamber, respectively. These results indicate that nicotine may be acting, at least in part, through a non-associative mechanism to reinstate methamphetamine-seeking behavior.

  10. Recovery of cholinesterase activity in mallard ducklings administered organophosphorus pesticides

    USGS Publications Warehouse

    Fleming, W.J.; Bradbury, S.P.

    1981-01-01

    Oral doses of the organophosphorus pesticides acephate, dicrotophos, fensulfothion, fonofos, malathion, and parathion were administered to mallard ducklings (Anas platyrhynchos), and brain and plasma cholinesterase (ChE) activities were determined for up to 77 d after dosing. In vivo recovery of brain ChE activity to within 2 standard deviations of the mean activity of undosed birds occurred within 8 d, after being depressed an average of 25-58% at 24 h after dosing. In vivo recovery of plasma ChE appeared as fast as or faster than that of brain, but the pattern of recovery was more erratic and therefore statistical comparison with brain ChE recovery was not attempted. In vitro tests indicated that the potential for dephosphorylation to contribute to in vivo recovery of inhibited brain ChE differed among chemical treatments. Some ducklings died as a result of organophosphate dosing. In an experiment in which ducklings within each treatment group received the same dose (mg/kg), the brain ChE activity in birds that died was less than that in birds that survived. Brain ChE activities in ducklings that died were significantly different among pesticide treatments: fensulfothion > parathion> acephate > malathion (p < 0.05).

  11. Suppression of reagin synthesis in rabbits by passively administered antibody

    PubMed Central

    Strannegård, Ö.; Belin, L.

    1970-01-01

    The formation of rabbit antibodies, capable of sensitizing homologous skin, (reagins), was completely inhibited by passive administration of serum containing large quantities of 7S antibody 24 hours before or after antigen injection. No evident effect on reagin formation was noted when passive antibody was administered 8 days after antigen injection although some suppression of agglutinating antibody synthesis was observed. In rabbits not treated with passive antibody the injection of haemocyanin resulted in the formation of reagins reaching maximum serum concentrations 1 and 3 weeks following antigen injection. Both the `early' and `late' reagins persisted for a long time in the skin of injected rabbits, they appeared to have similar molecular size and both were devoid of PCA activity when injected into decomplemented rabbits. There was some indication that the `early' reagins may be more heat-labile than the `late' ones. A secondary reagin response was obtained in several animals which had shown a primary reagin response, but not in rabbits with inhibited primary response. The reagins formed in response to secondary antigen stimulation disappeared rapidly from the circulation, simultaneously with the rise in agglutinating antibody titres. The possible implications of the findings for the immunological treatment of allergic disorders is discussed. PMID:5420728

  12. Effects of Systemically Administered Hydrocortisone on the Human Immunome

    PubMed Central

    Olnes, Matthew J.; Kotliarov, Yuri; Biancotto, Angélique; Cheung, Foo; Chen, Jinguo; Shi, Rongye; Zhou, Huizhi; Wang, Ena; Tsang, John S.; Nussenblatt, Robert; Dickler, Howard B.; Hourigan, Christopher S.; Marincola, Francesco M.; McCoy, J. Phillip; Perl, Shira; Schum, Paula; Schwartzberg, Pamela L.; Trinchieri, Giorgio; Valdez, Janet; Young, Neal S.

    2016-01-01

    Corticosteroids have been used for decades to modulate inflammation therapeutically, yet there is a paucity of data on their effects in humans. We examined the changes in cellular and molecular immune system parameters, or “immunome”, in healthy humans after systemic corticosteroid administration. We used multiplexed techniques to query the immunome in 20 volunteers at baseline, and after intravenous hydrocortisone (HC) administered at moderate (250 mg) and low (50 mg) doses, to provide insight into how corticosteroids exert their effects. We performed comprehensive phenotyping of 120 lymphocyte subsets by high dimensional flow cytometry, and observed a decline in circulating specific B and T cell subsets, which reached their nadir 4–8 hours after administration of HC. However, B and T cells rebounded above baseline 24 hours after HC infusion, while NK cell numbers remained stable. Whole transcriptome profiling revealed down regulation of NF-κB signaling, apoptosis, and cell death signaling transcripts that preceded lymphocyte population changes, with activation of NK cell and glucocorticoid receptor signaling transcripts. Our study is the first to systematically characterize the effects of corticosteroids on the human immunome, and we demonstrate that HC exerts differential effects on B and T lymphocytes and natural killer cells in humans. PMID:26972611

  13. Correlation between administered treatment and patient’s living will

    PubMed Central

    Andreoni, B; Goldhirsch, A; Orecchia, R; Venturino, M; Spirito, R; Tadini, L; Corbellini, C; Bertani, E; Veronesi, U

    2009-01-01

    Respecting the wishes of an adequately informed patient should be a priority in any health structure. A patient with advanced or terminal cancer should be allowed to express their will during the most important phases of their illness. Unfortunately, this is seldom the case, and in general instructions regarding an individual’s medical care preferences, i.e., their ‘living will’, expressed when healthy, often change with the onset of a serious illness. At the European Institute of Oncology (IEO), a clinical study is ongoing to verify whether, during clinical practice, the patient is adequately informed to sign an ‘informed consent’, in a fully aware manner, that will allow the patient and doctor to share in the decisions regarding complex treatment strategies (living will). A further aim of the study is to verify if health workers, both in hospital and at home, respect the patient’s will. The observational study ‘Respecting the patient’s wishes: Correlation between administered treatment and that accepted by the patient in their Living Will’ was approved by the IEO Ethical Committee in April 2008. PMID:22276019

  14. [What lipid emulsion should be administered to ICU patients?].

    PubMed

    Kreymann, G

    2014-01-01

    The review deals with a question what lipid emulsion should be administered to ICU patients according to recently published official parenteral and enteral nutrition guidelines. Classic lipid emulsions based on omega-6 fatty acids are immunosuppressive and should not be used with ICU patients. The olive/soy emulsion is immunoneutral and can be used for most patients. Many ICU patients are in an inflammatory state (e.g. sepsis, ARDS, pancreatitis). A common belief is that this "hyperinflammed patient population" would profit from an anti-inflammatory lipid component of their parenteral nutrition solution, such as fish oil. On the other hand, every anti-inflammatory therapy has the disadvantage of also being immunosuppressive. Inflammation is a necessary part of the host defense against infection and any correct anti-inflammatory medication presupposes the exact immunologic knowledge that there is too much inflammation for a given situation. This "too much" is certainly not fulfilled in every patient with sepsis, ARDS or pancreatitis. At the bedside it is nearly impossible to determine the degree of "hyper" inflammation. In reality, a number of these patients may be adequately inflamed or, in fact, even hypoinflammed. Specific emulsions which can be used in hyper- or hypoinflammation should be developed in the future. As long as these difficulties in the immunologic diagnosis prevail, the clinician might be best advised to use an immunoneutral lipid emulsion when choosing a lipid preparation for the ICU patients. PMID:25306684

  15. Macroscopic and microscopic biodistribution of intravenously administered iron oxide nanoparticles

    NASA Astrophysics Data System (ADS)

    Misra, Adwiteeya; Petryk, Alicia A.; Strawbridge, Rendall R.; Hoopes, P. Jack

    2015-03-01

    Iron oxide nanoparticles (IONP) are being developed for use as a cancer treatment. They have demonstrated efficacy when used either as a monotherapy or in conjunction with conventional chemotherapy and radiation. The success of IONP as a therapeutic tool depends on the delivery of a safe and controlled cytotoxic thermal dose to tumor tissue following activation with an alternating magnetic field (AMF). Prior to clinical approval, knowledge of IONP toxicity, biodistribution and physiological clearance is essential. This preliminary time-course study determines the acute toxicity and biodistribution of 110 nm dextran-coated IONP (iron) in mice, 7 days post systemic, at doses of 0.4, 0.6, and 1.0 mg Fe/ g mouse bodyweight. Acute toxicity, manifested as changes in the behavior of mice, was only observed temporarily at 1.0 mg Fe/ g mouse bodyweight, the highest dose administered. Regardless of dose, mass spectrometry and histological analysis demonstrated over 3 mg Fe/g tissue in organs within the reticuloendotheilial system (i.e. liver, spleen, and lymph nodes). Other organs (brain, heart, lungs, and kidney) had less than 0.5 mg Fe/g tissue with iron predominantly confined to the organ vasculature.

  16. 40 CFR 180.515 - Carfentrazone-ethyl; tolerances for residues.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 0.10 Kava, roots 0.10 Kiwifruit 0.10 Lingonberry 0.10 Longan 0.10 Lychee 0.10 Mango 0.10 Milk 0.05... apple 0.10 Sugarcane 0.15 Sunflower, seed 0.10 Tea, dried 0.10 Ti, leaves 0.10 Ti, roots 0.10 Vanilla 0....10 Vegetable, leafy, except brassica, group 4 0.10 Vegetable, leaves of root and tuber, group 2...

  17. 40 CFR 180.515 - Carfentrazone-ethyl; tolerances for residues.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 0.10 Kava, roots 0.10 Kiwifruit 0.10 Lingonberry 0.10 Longan 0.10 Lychee 0.10 Mango 0.10 Milk 0.05... apple 0.10 Sugarcane 0.15 Sunflower, seed 0.10 Tea, dried 0.10 Ti, leaves 0.10 Ti, roots 0.10 Vanilla 0....10 Vegetable, leafy, except brassica, group 4 0.10 Vegetable, leaves of root and tuber, group 2...

  18. 40 CFR 180.515 - Carfentrazone-ethyl; tolerances for residues.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....10 Jaboticaba 0.10 Juneberry 0.10 Kava, roots 0.10 Kiwifruit 0.10 Lingonberry 0.10 Longan 0.10 Lychee..., leaves 0.10 Ti, roots 0.10 Vanilla 0.10 Vegetable, brassica, leafy, group 5 0.10 Vegetable, bulb, group 3..., leaves of root and tuber, group 2 0.10 Vegetable, legume, group 6 0.10 Vegetable, root and tuber, group...

  19. 21 CFR 1306.07 - Administering or dispensing of narcotic drugs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Administering or dispensing of narcotic drugs... PRESCRIPTIONS General Information § 1306.07 Administering or dispensing of narcotic drugs. (a) A practitioner may administer or dispense directly (but not prescribe) a narcotic drug listed in any schedule to...

  20. 21 CFR 1306.07 - Administering or dispensing of narcotic drugs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Administering or dispensing of narcotic drugs... PRESCRIPTIONS General Information § 1306.07 Administering or dispensing of narcotic drugs. (a) A practitioner may administer or dispense directly (but not prescribe) a narcotic drug listed in any schedule to...

  1. 21 CFR 1306.07 - Administering or dispensing of narcotic drugs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Administering or dispensing of narcotic drugs... PRESCRIPTIONS General Information § 1306.07 Administering or dispensing of narcotic drugs. (a) A practitioner may administer or dispense directly (but not prescribe) a narcotic drug listed in any schedule to...

  2. 21 CFR 1306.07 - Administering or dispensing of narcotic drugs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Administering or dispensing of narcotic drugs... PRESCRIPTIONS General Information § 1306.07 Administering or dispensing of narcotic drugs. (a) A practitioner may administer or dispense directly (but not prescribe) a narcotic drug listed in any schedule to...

  3. 21 CFR 1306.07 - Administering or dispensing of narcotic drugs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Administering or dispensing of narcotic drugs... PRESCRIPTIONS General Information § 1306.07 Administering or dispensing of narcotic drugs. (a) A practitioner may administer or dispense directly (but not prescribe) a narcotic drug listed in any schedule to...

  4. 40 CFR 147.2601 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....2601 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the territory of Guam is administered by EPA. This program consists of the UIC program requirements of 40 CFR... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian...

  5. 40 CFR 147.2510 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 147.2510 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the State of Wisconsin is administered by EPA. This program consists of 40 CFR parts 144 and 146 and... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian...

  6. 40 CFR 147.2601 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....2601 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the territory of Guam is administered by EPA. This program consists of the UIC program requirements of 40 CFR... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian...

  7. 40 CFR 147.2510 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 147.2510 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the State of Wisconsin is administered by EPA. This program consists of 40 CFR parts 144 and 146 and... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian...

  8. 45 CFR 400.66 - Eligibility and payment levels in a publicly-administered RCA program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Refugee Cash Assistance § 400.66 Eligibility and payment levels in a publicly-administered RCA program. (a) In administering a publicly-administered refugee cash assistance program,...

  9. 77 FR 19425 - Prescription Drugs Not Administered During Treatment; Update to Administrative Cost for Calendar...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... AFFAIRS Prescription Drugs Not Administered During Treatment; Update to Administrative Cost for Calendar... purposes of calculating VA's charges for prescription drugs that were not administered during treatment but... administered during treatment for: (1) A nonservice-connected disability for which the veteran is entitled...

  10. 34 CFR 461.1 - What is the Adult Education State-administered Basic Grant Program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What is the Adult Education State-administered Basic... (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM General § 461.1 What is the Adult Education State-administered Basic...

  11. 34 CFR 461.1 - What is the Adult Education State-administered Basic Grant Program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What is the Adult Education State-administered Basic... (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM General § 461.1 What is the Adult Education State-administered Basic...

  12. 34 CFR 461.1 - What is the Adult Education State-administered Basic Grant Program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What is the Adult Education State-administered Basic... (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM General § 461.1 What is the Adult Education State-administered Basic...

  13. 34 CFR 461.1 - What is the Adult Education State-administered Basic Grant Program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What is the Adult Education State-administered Basic... (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM General § 461.1 What is the Adult Education State-administered Basic...

  14. 34 CFR 461.1 - What is the Adult Education State-administered Basic Grant Program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the Adult Education State-administered Basic... (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION ADULT EDUCATION STATE-ADMINISTERED BASIC GRANT PROGRAM General § 461.1 What is the Adult Education State-administered Basic...

  15. Liver regeneration in rats administered high levels of carbohydrates.

    PubMed

    Gershbein, L L

    1976-01-01

    Partially hepatectomized male rats were administered high levels of carbohydrates by drinker, in a casein-cellulose synthetic medium and in a commercial meal over a period of 10 days after surgery and the amount of liver regenerating or the increment ascertained; representative hepatic glycogen changes were also followed. Of the carbohydrate solutions, 5% levulose, 5% levulose+5% glucose and 10% sucrose increased the extent of liver regeneration as was also the case with the synthetic diet suplemented with 30 and 60% glucose, 30 and 60% levulose, 30% levulose+30% glucose, 30% each of galactose and the arabinoglactan, Stractan and 60% each of sucrose, honey and unsulphured molasses. The liver increments and glycogen contents were in the control range for animals fed the synthetic diet containing 30% each of lactose, sorbitol, corn starch and raffinose pentahydrate, 5% ascorbic acid and 15% L-arabinose but the liver glycogen was depressed with 30% xylose, a diet which was poorly tolerated; 15% mannitol caused a decrease inthe increment. The incorporation of several sugars into the commercial rat meal, including xylose (11%), raffinose (15%), L-arabinose (8%), D-arabinose (5%), L-sorbose (17%), galactosamine (0.20%) and galactono-gamma-lactone (10%), led to little change over the control increments. In intact rats fed the synthetic diet containing 30% each of glucose, lactose, galactose, sucrose and levulose for an interval of 10 days, the wet and dry liver--body weight ratios were significantly elevated only with the last two sugars but liver glycogen was increased in each instance.

  16. Maternal Satisfaction with Administering Infant Interventions in the NICU

    PubMed Central

    Holditch-Davis, Diane; White-Traut, Rosemary; Levy, Janet; Williams, Kristi L.; Ryan, Donna; Vonderheid, Susan

    2015-01-01

    Objective To examine mothers’ satisfaction with administering interventions for their preterm infants and with the helpfulness of the study nurse by comparing the ATVV intervention (massage with auditory, tactile, visual, and vestibular stimulation), kangaroo care, and education about equipment needed at home. Secondarily, to explore whether mother and infant characteristics affected maternal satisfaction ratings. Design Three-group experimental design. Setting Four NICUs (two in North Carolina, two in Illinois). Participants 208 preterm infants and their mothers. Methods When the infant was no longer critically ill, mother-infant dyads were randomly assigned to ATVV, kangaroo care, or the education group, all taught by study nurses. At discharge and 2 months corrected age, mothers completed questionnaires. Results All groups were satisfied with the intervention and with nurse helpfulness, and the degree of satisfaction did not differ among them. Intervention satisfaction, but not nurse helpfulness, was related to recruitment site. Older, married, and minority mothers were less satisfied with the intervention but only at 2 months. Higher anxiety was related to lower intervention satisfaction at discharge and lower ratings of nurse helpfulness at discharge and 2 months. More depressive symptoms were related to lower nurse helpfulness ratings at 2 months. Conclusions Mothers were satisfied with providing interventions for their infants regardless of the intervention performed. Maternal satisfaction with the intervention was related to recruitment site, maternal demographic characteristics, and maternal psychological distress, especially at 2 months. Thus, nursing interventions that provide mothers with a role to play in the infant’s care during hospitalization are particularly likely to be appreciated by mothers. PMID:25803213

  17. Contemporary Pacific and Western perspectives on `awa (Piper methysticum) toxicology.

    PubMed

    Showman, Angelique F; Baker, Jonathan D; Linares, Christina; Naeole, Chrystie K; Borris, Robert; Johnston, Edward; Konanui, Jerry; Turner, Helen

    2015-01-01

    In 2010, a National Science Foundation project in Hawai`i assembled a collaboration of Pacific indigenous scientists, Hawaiian cultural practitioners and scientists trained in Western pharmacology. The objective of the collaborative project was to study Kava, a culturally significant Pacific beverage, and to address and ultimately transcend, long-standing barriers to communication and collaboration between these groups. Kava is a product of the `awa plant (Piper methysticum) that has been used ceremonially and medicinally throughout the history of Pacific Island cultures, and is now in widespread recreational and nutraceutical use in the US. This project, culminating in 2015, has enriched the participants, led to published work that integrates cultural and Western pharmacologic perspectives and established a paradigm for collaboration. This review paper integrates cultural and Western perspectives on efficacy, toxicity and the future cultural and commercial significance of `awa in the Pacific. Here we present a detailed review of traditional and non-traditional kava usage, medicinal efficacy and potential toxicological concerns. Recent mechanistic data on physiological action and potential pathological reactions are evaluated and interpreted.

  18. Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.

    PubMed

    Hu, Lihong; Jhoo, Jin-Woo; Ang, Catharina Y W; Dinovi, Michael; Mattia, Antonia

    2005-01-01

    Kava (Piper methysticum) dietary products have been sold worldwide for treatment of nervous anxiety, tension, and restlessness. Recent reports showed potential association of kava usage and liver injuries. This study was conducted to develop simple and reliable methodologies for the extraction and determination of 6 major kavalactones: (+)-methysticin, (+)-dihydromethysticin, (+)-kavain, (+)-dihydrokavain, yangonin, and desmethoxyyangonin. Ultrasonic extraction techniques and isocratic reversed-phase liquid chromatography (LC) were optimized for different types of samples, including capsules containing kava root extract or root powder, raw root material, tea bags, and snack bar. A suitable internal standard, 5,7-dihydroxyflavone, was used for LC calibration. Kavalactones were completely separated in 30 min using a Luna C18-2 column at 60 degrees C with an isocratic mobile phase consisting of 2-propanol-acetonitrile-water-acetic acid (16 + 16 + 68 + 0.1, v/v/v/v). Within-laboratory, intraday, and interday method variation (% relative standard deviation) for most samples extracted by methanol or methanol-water mixture were <5%. Lower levels of kavalactone contents and higher variations were observed for tea bags from water extraction or infusion as compared to methanol extraction. Labeling information of tea bags based on methanol extraction could be misleading to consumers. Analytical recoveries of snack bar fortified at 10 and 20 microg/g were >84% with RSD values <8%. Methods developed in this study offer a simple and reproducible means for analysis of kavalactones in various matrixes of dietary products. PMID:15759721

  19. The accuracy of a patient or parent-administered bleeding assessment tool administered in a paediatric haematology clinic.

    PubMed

    Lang, A T; Sturm, M S; Koch, T; Walsh, M; Grooms, L P; O'Brien, S H

    2014-11-01

    Classifying and describing bleeding symptoms is essential in the diagnosis and management of patients with mild bleeding disorders (MBDs). There has been increased interest in the use of bleeding assessment tools (BATs) to more objectively quantify the presence and severity of bleeding symptoms. To date, the administration of BATs has been performed almost exclusively by clinicians; the accuracy of a parent-proxy BAT has not been studied. Our objective was to determine the accuracy of a parent-administered BAT by measuring the level of agreement between parent and clinician responses to the Condensed MCMDM-1VWD Bleeding Questionnaire. Our cross-sectional study included children 0-21 years presenting to a haematology clinic for initial evaluation of a suspected MBD or follow-up evaluation of a previously diagnosed MBD. The parent/caregiver completed a modified version of the BAT; the clinician separately completed the BAT through interview. The mean parent-report bleeding score (BS) was 6.09 (range: -2 to 25); the mean clinician report BS was 4.54 (range: -1 to 17). The mean percentage of agreement across all bleeding symptoms was 78% (mean κ = 0.40; Gwet's AC1 = 0.74). Eighty percent of the population had an abnormal BS (defined as ≥2) when rated by parents and 76% had an abnormal score when rated by clinicians (86% agreement, κ = 0.59, Gwet's AC1 = 0.79). While parents tended to over-report bleeding as compared to clinicians, overall, BSs were similar between groups. These results lend support for further study of a modified proxy-report BAT as a clinical and research tool.

  20. Influence of intravenously administered ciprofloxacin on aerobic intestinal microflora and fecal drug levels when administered simultaneously with sucralfate.

    PubMed Central

    Krueger, W A; Ruckdeschel, G; Unertl, K

    1997-01-01

    Ciprofloxacin, when given intravenously (i.v.), is secreted in significant amounts via the mucosa into the intestinal lumen. Sucralfate inhibits the antimicrobial activity of ciprofloxacin. The effect of combined therapy on the intestinal flora was investigated in 16 healthy volunteers. They were randomly assigned to two groups. Group A received 2 g of sucralfate orally three times a day for 7 days and 400 mg of ciprofloxacin i.v. twice a day (b.i.d.) starting 3 days after the sucralfate administration began. Group B was given only 400 mg of ciprofloxacin i.v. b.i.d. for 4 days. A total of 9 stool samples were collected from each subject beginning the week before ciprofloxacin was administered and on days -1, 1, 2, 3, 4, 7, 9, and 10 or 11 after commencement of the infusion period. The aerobic fecal flora was determined by standard microbiological methods. Measurements of fecal ciprofloxacin levels were based on high-performance liquid chromatography. Counts of bacteria of the family Enterobacteriaceae decreased in all subjects and were below 10(2) CFU/g in eight of eight subjects (group A) and six of eight subjects (group B) on day 4, but they returned to normal in all but one subject (group A) 10 days after the last infusion. The decreases in levels of bacteria of the family Enterobacteriaceae were not significantly different in groups A and B (Kaplan-Meier test). Staphylococci and nonfermenters responded variably, enterococci and lactobacilli remained unchanged, and candida levels increased transiently in four subjects (two in each group). Maximum fecal drug levels ranged from 251 to 811 microg/g. No significant difference could be found between the two groups. The i.v. application of ciprofloxacin eliminates intestinal bacteria of the family Enterobacteriaceae in a rapid and selective manner. This effect is not affected by simultaneous oral application of sucralfate. PMID:9257749

  1. Comparison of total costs of administering calcium polycarbophil and psyllium mucilloid in an institutional setting.

    PubMed

    Mamtani, R; Cimino, J A; Cooperman, J M; Kugel, R

    1990-01-01

    The total cost of administering calcium polycarbophil per unit dose (two tablets) was compared with that of administering psyllium mucilloid (one packet dissolved in 8 oz of water) in 20 elderly nursing-home residents. Times for printing labels, checking and initialing labels, gathering materials needed, and preparing and administering the medications were recorded during at least 50 observations in each treatment group. Total cost included nurses' and pharmacists' time, materials, and medications. Calcium polycarbophil doses were prepared and administered more quickly (mean, 49.5 sec) than psyllium mucilloid (105.3 sec). The mean cost of preparing and administering a unit dose was 28.2 for calcium polycarbophil tablets and 59.9 for psyllium mucilloid. The results suggest that the use of calcium polycarbophil tablets would save time and money in institutions in which laxatives are frequently administered.

  2. 34 CFR 406.1 - What is the State-Administered Tech-Prep Education Program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What is the State-Administered Tech-Prep Education Program? 406.1 Section 406.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE-ADMINISTERED...

  3. 34 CFR 406.1 - What is the State-Administered Tech-Prep Education Program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What is the State-Administered Tech-Prep Education Program? 406.1 Section 406.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE-ADMINISTERED...

  4. 34 CFR 406.1 - What is the State-Administered Tech-Prep Education Program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What is the State-Administered Tech-Prep Education Program? 406.1 Section 406.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE-ADMINISTERED...

  5. 34 CFR 406.1 - What is the State-Administered Tech-Prep Education Program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What is the State-Administered Tech-Prep Education Program? 406.1 Section 406.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE-ADMINISTERED...

  6. 7 CFR 4280.195 - Awarding and administering energy audit and renewable energy development assistance grants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Awarding and administering energy audit and renewable... OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Energy Audit and Renewable Energy Development Assistance Grants § 4280.195 Awarding and administering energy audit and...

  7. 7 CFR 4280.195 - Awarding and administering energy audit and renewable energy development assistance grants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Awarding and administering energy audit and renewable... OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Energy Audit and Renewable Energy Development Assistance Grants § 4280.195 Awarding and administering energy audit and...

  8. 7 CFR 4280.195 - Awarding and administering energy audit and renewable energy development assistance grants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Awarding and administering energy audit and renewable... OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Energy Audit and Renewable Energy Development Assistance Grants § 4280.195 Awarding and administering energy audit and...

  9. 40 CFR 147.1851 - State-administered program-Class II wells.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Oklahoma § 147.1851 State-administered program—Class II wells. The UIC program for Class II wells in the State of Oklahoma, including the lands of the Five Civilized Tribes, but not including those on other Indian lands, is the program administered by the Oklahoma Corporation Commission approved by EPA...

  10. 40 CFR 147.1851 - State-administered program-Class II wells.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Oklahoma § 147.1851 State-administered program—Class II wells. The UIC program for Class II wells in the State of Oklahoma, including the lands of the Five Civilized Tribes, but not including those on other Indian lands, is the program administered by the Oklahoma Corporation Commission approved by EPA...

  11. 40 CFR 147.1851 - State-administered program-Class II wells.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Oklahoma § 147.1851 State-administered program—Class II wells. The UIC program for Class II wells in the State of Oklahoma, including the lands of the Five Civilized Tribes, but not including those on other Indian lands, is the program administered by the Oklahoma Corporation Commission approved by EPA...

  12. 40 CFR 147.1851 - State-administered program-Class II wells.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Oklahoma § 147.1851 State-administered program—Class II wells. The UIC program for Class II wells in the State of Oklahoma, including the lands of the Five Civilized Tribes, but not including those on other Indian lands, is the program administered by the Oklahoma Corporation Commission approved by EPA...

  13. 40 CFR 282.83 - North Carolina State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false North Carolina State-Administered Program. 282.83 Section 282.83 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.83 North Carolina State-Administered Program. (a)...

  14. 40 CFR 282.98 - West Virginia State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false West Virginia State-Administered Program. 282.98 Section 282.98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.98 West Virginia State-Administered Program. (a)...

  15. 20 CFR 672.200 - How are YouthBuild grants funded and administered?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false How are YouthBuild grants funded and... How are YouthBuild grants funded and administered? The Secretary uses funds authorized for appropriation under sec. 173A of the Workforce Investment Act (WIA) to administer YouthBuild as a...

  16. 20 CFR 672.200 - How are YouthBuild grants funded and administered?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false How are YouthBuild grants funded and... How are YouthBuild grants funded and administered? The Secretary uses funds authorized for appropriation under sec. 173A of the Workforce Investment Act (WIA) to administer YouthBuild as a...

  17. 20 CFR 672.200 - How are YouthBuild grants funded and administered?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false How are YouthBuild grants funded and... How are YouthBuild grants funded and administered? The Secretary uses funds authorized for appropriation under sec. 173A of the Workforce Investment Act (WIA) to administer YouthBuild as a...

  18. 40 CFR 272.151 - Arizona State-administered program: Final authorization.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Arizona State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.151 Arizona State-administered program: Final authorization. (a) Pursuant to section 3006(b) of RCRA, 42...

  19. 40 CFR 272.151 - Arizona State-administered program: Final authorization.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Arizona State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.151 Arizona State-administered program: Final authorization. (a) Pursuant to section 3006(b) of RCRA, 42...

  20. 40 CFR 272.151 - Arizona State-administered program: Final authorization.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Arizona State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona § 272.151 Arizona State-administered program: Final authorization. (a) Pursuant to section 3006(b) of RCRA, 42...

  1. 40 CFR 272.1201 - Minnesota State-administered program; Final authorization.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Minnesota State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Minnesota § 272.1201 Minnesota State-administered program; Final authorization. Pursuant to section 3006(b) of RCRA, 42...

  2. 40 CFR 272.1201 - Minnesota State-administered program; Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Minnesota State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Minnesota § 272.1201 Minnesota State-administered program; Final authorization. Pursuant to section 3006(b) of RCRA, 42...

  3. 40 CFR 272.1201 - Minnesota State-administered program; Final authorization.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Minnesota State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Minnesota § 272.1201 Minnesota State-administered program; Final authorization. Pursuant to section 3006(b) of RCRA, 42...

  4. 40 CFR 272.1201 - Minnesota State-administered program; Final authorization.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Minnesota State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Minnesota § 272.1201 Minnesota State-administered program; Final authorization. Pursuant to section 3006(b) of RCRA, 42...

  5. 40 CFR 272.1201 - Minnesota State-administered program; Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Minnesota State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Minnesota § 272.1201 Minnesota State-administered program; Final authorization. Pursuant to section 3006(b) of RCRA, 42...

  6. 40 CFR 147.1451 - EPA administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA administered program-Indian lands... § 147.1451 EPA administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  7. 40 CFR 147.1703 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Carolina § 147.1703 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  8. 40 CFR 147.2001 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Island § 147.2001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  9. 40 CFR 147.1053 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1053 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  10. 40 CFR 147.2253 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... wells on Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands....2253 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  11. 40 CFR 147.60 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148 and any additional requirements set forth in the remainder of... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.60 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  12. 40 CFR 147.1752 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Dakota § 147.1752 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  13. 40 CFR 147.2651 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the UIC program requirements of 40 CFR parts 124, 144, 146, 148 and any additional requirements set... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.2651 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  14. 40 CFR 147.1703 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Carolina § 147.1703 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  15. 40 CFR 147.1403 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.1403 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  16. 40 CFR 147.2553 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.2553 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  17. 40 CFR 147.2453 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Virginia § 147.2453 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  18. 40 CFR 147.2403 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... except those of the Colville Tribe, consists of the UIC program requirements of 40 CFR parts 124, 144... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.2403 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  19. 40 CFR 147.2001 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Island § 147.2001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  20. 40 CFR 147.651 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands....651 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  1. 40 CFR 147.1551 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1551 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  2. 40 CFR 147.1303 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 145, 146, 148, and any additional requirements set forth in... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.1303 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  3. 40 CFR 147.2253 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... wells on Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands....2253 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  4. 40 CFR 147.205 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148 and any additional requirements set forth in this subpart... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.205 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  5. 40 CFR 147.860 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.860 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  6. 40 CFR 147.2403 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... except those of the Colville Tribe, consists of the UIC program requirements of 40 CFR parts 124, 144... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.2403 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  7. 40 CFR 147.1805 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands....1805 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  8. 40 CFR 147.205 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148 and any additional requirements set forth in this subpart... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.205 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  9. 40 CFR 147.60 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148 and any additional requirements set forth in the remainder of... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.60 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  10. 40 CFR 147.703 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.703 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  11. 40 CFR 147.1752 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Dakota § 147.1752 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  12. 40 CFR 147.553 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.553 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  13. 40 CFR 147.1805 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands....1805 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  14. 40 CFR 147.1901 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.1901 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  15. 40 CFR 147.2205 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands....2205 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  16. 40 CFR 147.2303 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.2303 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  17. 40 CFR 147.1053 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.1053 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  18. 40 CFR 147.1252 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.1252 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  19. 40 CFR 147.1001 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands....1001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  20. 40 CFR 147.403 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.403 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  1. 40 CFR 147.2051 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Carolina § 147.2051 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  2. 40 CFR 147.1852 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1852 EPA-administered program—Indian lands. (a) Contents. The UIC program for all wells on Indian... forth in subpart GGG of this part. The UIC program for all other wells on Indian lands consists of...

  3. 40 CFR 147.2651 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the UIC program requirements of 40 CFR parts 124, 144, 146, 148 and any additional requirements set... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.2651 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  4. 40 CFR 147.2303 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.2303 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  5. 40 CFR 147.1101 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Massachusetts § 147.1101 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  6. 40 CFR 147.703 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.703 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  7. 40 CFR 147.353 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.353 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  8. 40 CFR 147.1403 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1403 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  9. 40 CFR 147.1501 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Hampshire § 147.1501 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  10. 40 CFR 147.2051 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Carolina § 147.2051 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  11. 40 CFR 147.1303 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 145, 146, 148, and any additional requirements set forth in... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1303 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  12. 40 CFR 147.1101 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Massachusetts § 147.1101 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  13. 40 CFR 147.1451 - EPA administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA administered program-Indian lands... § 147.1451 EPA administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  14. 40 CFR 147.860 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.860 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  15. 40 CFR 147.1252 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1252 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  16. 40 CFR 147.1001 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands....1001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  17. 40 CFR 147.2205 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands....2205 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  18. 40 CFR 147.951 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.951 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  19. 40 CFR 147.2453 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Virginia § 147.2453 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  20. 40 CFR 147.1603 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1603 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in New Mexico, except for Class II wells on Navajo Indian lands for which EPA...

  1. 40 CFR 147.553 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.553 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  2. 40 CFR 147.651 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands....651 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  3. 40 CFR 147.353 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.353 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  4. 40 CFR 147.403 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.403 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  5. 40 CFR 147.1551 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.1551 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  6. 40 CFR 147.1501 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Hampshire § 147.1501 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes...

  7. 40 CFR 147.951 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.951 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  8. 40 CFR 147.1901 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.1901 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  9. 40 CFR 147.2553 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... § 147.2553 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of...

  10. 40 CFR 147.1852 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... § 147.1852 EPA-administered program—Indian lands. (a) Contents. The UIC program for all wells on Indian... forth in subpart GGG of this part. The UIC program for all other wells on Indian lands consists of...

  11. 47 CFR 64.1110 - State notification of election to administer FCC rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false State notification of election to administer FCC rules. 64.1110 Section 64.1110 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... Telecommunications Service Providers § 64.1110 State notification of election to administer FCC rules. (a)...

  12. 42 CFR 2a.5 - Contents of application; research projects in which drugs will be administered.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Contents of application; research projects in which... application; research projects in which drugs will be administered. (a) In addition to the information... for an authorization of confidentiality for a research project which involves the administering of...

  13. 42 CFR 2a.5 - Contents of application; research projects in which drugs will be administered.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Contents of application; research projects in which... application; research projects in which drugs will be administered. (a) In addition to the information... for an authorization of confidentiality for a research project which involves the administering of...

  14. 42 CFR 2a.5 - Contents of application; research projects in which drugs will be administered.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Contents of application; research projects in which... application; research projects in which drugs will be administered. (a) In addition to the information... for an authorization of confidentiality for a research project which involves the administering of...

  15. 40 CFR 272.501 - Florida State-administered program: Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Florida State-administered program... (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Florida § 272.501 Florida State-administered program: Final authorization. (a) Pursuant to section 3006(b) of RCRA, 42...

  16. 40 CFR 282.98 - West Virginia State-Administered Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... it more stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281... 40 Protection of Environment 27 2014-07-01 2014-07-01 false West Virginia State-Administered... Virginia State-Administered Program. (a) The State of West Virginia's underground storage tank program...

  17. 40 CFR 147.2453 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Virginia § 147.2453 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in the State of West Virginia is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set...

  18. 40 CFR 282.98 - West Virginia State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... it more stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281... 40 Protection of Environment 27 2011-07-01 2011-07-01 false West Virginia State-Administered... Virginia State-Administered Program. (a) The State of West Virginia's underground storage tank program...

  19. 40 CFR 147.2453 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Virginia § 147.2453 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in the State of West Virginia is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set...

  20. 40 CFR 282.98 - West Virginia State-Administered Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... it more stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281... 40 Protection of Environment 28 2013-07-01 2013-07-01 false West Virginia State-Administered... Virginia State-Administered Program. (a) The State of West Virginia's underground storage tank program...

  1. 25 CFR 26.4 - Who administers the Job Placement and Training Program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Who administers the Job Placement and Training Program? 26.4 Section 26.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.4 Who administers the Job Placement and...

  2. 25 CFR 26.4 - Who administers the Job Placement and Training Program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Who administers the Job Placement and Training Program? 26.4 Section 26.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.4 Who administers the Job Placement and...

  3. 25 CFR 26.4 - Who administers the Job Placement and Training Program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Who administers the Job Placement and Training Program? 26.4 Section 26.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.4 Who administers the Job Placement and...

  4. 42 CFR 2a.5 - Contents of application; research projects in which drugs will be administered.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Contents of application; research projects in which... application; research projects in which drugs will be administered. (a) In addition to the information... for an authorization of confidentiality for a research project which involves the administering of...

  5. 39 CFR 222.2 - Authority to administer oaths or function as notaries public.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Authority to administer oaths or function as notaries public. 222.2 Section 222.2 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION DELEGATIONS OF AUTHORITY § 222.2 Authority to administer oaths or function as notaries public. (a) Authority to approve personnel actions...

  6. 48 CFR 3004.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Closeout by the office administering the contract. 3004.804-1 Section 3004.804-1 Federal Acquisition Regulations System DEPARTMENT OF... Government Contract Files 3004.804-1 Closeout by the office administering the contract. (b) The...

  7. Comparing Social Desirability Responding on World Wide Web and Paper-Administered Surveys.

    ERIC Educational Resources Information Center

    Hancock, Dawson R.; Flowers, Claudia P.

    2001-01-01

    Examines social desirability responding (SDR) on surveys administered on the World Wide Web and on paper to graduate and undergraduate students. Discusses response bias; describes use of the Balanced Inventory of Desirable Responding; and reports findings that reveal no differences in SDR between the Web-administered and paper-administered…

  8. Alliance in Two Telephone-Administered Treatments: Relationship with Depression and Health Outcomes

    ERIC Educational Resources Information Center

    Beckner, Victoria; Vella, Lea; Howard, Isa; Mohr, David C.

    2007-01-01

    The present study examined the relationship between therapeutic alliance and both depression and health outcomes in a randomized clinical trial of 2 telephone-administered treatments with 97 clients with multiple sclerosis (MS). The 16-week, manualized treatments compared were telephone-administered cognitive-behavioral therapy (T-CBT) and…

  9. 40 CFR 147.2201 - State-administered program-Class II wells

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Texas § 147.2201 State-administered program—Class II wells The UIC program for Class II wells in the State of Texas, except for those wells on Indian lands, is the program administered by the Railroad Commission of Texas, approved by EPA pursuant to section 1425 of the SDWA. Notice of this approval...

  10. 40 CFR 147.2205 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Indian lands in the State of Texas is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Texas §...

  11. 40 CFR 147.2205 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Indian lands in the State of Texas is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Texas §...

  12. 40 CFR 147.2201 - State-administered program-Class II wells.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Texas § 147.2201 State-administered program—Class II wells. The UIC program for Class II wells in the State of Texas, except for those wells on Indian lands, is the program administered by the Railroad Commission of Texas, approved by EPA pursuant to section 1425 of the SDWA. Notice of this approval...

  13. 40 CFR 147.2201 - State-administered program-Class II wells.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Texas § 147.2201 State-administered program—Class II wells. The UIC program for Class II wells in the State of Texas, except for those wells on Indian lands, is the program administered by the Railroad Commission of Texas, approved by EPA pursuant to section 1425 of the SDWA. Notice of this approval...

  14. 40 CFR 131.8 - Requirements for Indian Tribes to administer a water quality standards program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... administer a water quality standards program. 131.8 Section 131.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS General Provisions § 131.8 Requirements for Indian Tribes to administer a water quality standards program. (a) The Regional Administrator,...

  15. 40 CFR 131.8 - Requirements for Indian Tribes to administer a water quality standards program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administer a water quality standards program. 131.8 Section 131.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS General Provisions § 131.8 Requirements for Indian Tribes to administer a water quality standards program. (a) The Regional Administrator,...

  16. 40 CFR 131.8 - Requirements for Indian Tribes to administer a water quality standards program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... administer a water quality standards program. 131.8 Section 131.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS General Provisions § 131.8 Requirements for Indian Tribes to administer a water quality standards program. (a) The Regional Administrator,...

  17. 40 CFR 131.8 - Requirements for Indian Tribes to administer a water quality standards program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... administer a water quality standards program. 131.8 Section 131.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS General Provisions § 131.8 Requirements for Indian Tribes to administer a water quality standards program. (a) The Regional Administrator,...

  18. 25 CFR 171.110 - How does BIA administer its irrigation facilities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA administer its irrigation facilities? 171.110 Section 171.110 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE General Provisions § 171.110 How does BIA administer its...

  19. 48 CFR 904.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... administering the contract. 904.804-1 Section 904.804-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL ADMINISTRATIVE MATTERS Government Contract Files 904.804-1 Closeout by the office administering the contract. (a) The Head of the Contracting Activity (HCA) shall ensure that...

  20. 48 CFR 4.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... administering the contract. 4.804-1 Section 4.804-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-1 Closeout by the office administering the contract. (a) Except as provided in paragraph (c) below, time standards for closing...

  1. 48 CFR 3004.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Government Contract Files 3004.804-1 Closeout by the office administering the contract. (b) The quick closeout procedures under (FAR) 48 CFR 42.708 may be used for the settlement of indirect costs under... administering the contract. 3004.804-1 Section 3004.804-1 Federal Acquisition Regulations System DEPARTMENT...

  2. 48 CFR 904.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... administering the contract. 904.804-1 Section 904.804-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL ADMINISTRATIVE MATTERS Government Contract Files 904.804-1 Closeout by the office administering the contract. (a) The Head of the Contracting Activity (HCA) shall ensure that...

  3. 48 CFR 4.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... administering the contract. 4.804-1 Section 4.804-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-1 Closeout by the office administering the contract. (a) Except as provided in paragraph (c) below, time standards for closing...

  4. 48 CFR 4.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... administering the contract. 4.804-1 Section 4.804-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-1 Closeout by the office administering the contract. (a) Except as provided in paragraph (c) below, time standards for closing...

  5. 48 CFR 904.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... administering the contract. 904.804-1 Section 904.804-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL ADMINISTRATIVE MATTERS Government Contract Files 904.804-1 Closeout by the office administering the contract. (a) The Head of the Contracting Activity (HCA) shall ensure that...

  6. 48 CFR 904.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... administering the contract. 904.804-1 Section 904.804-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL ADMINISTRATIVE MATTERS Government Contract Files 904.804-1 Closeout by the office administering the contract. (a) The Head of the Contracting Activity (HCA) shall ensure that...

  7. 48 CFR 4.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... administering the contract. 4.804-1 Section 4.804-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-1 Closeout by the office administering the contract. (a) Except as provided in paragraph (c) below, time standards for closing...

  8. 48 CFR 4.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... administering the contract. 4.804-1 Section 4.804-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-1 Closeout by the office administering the contract. (a) Except as provided in paragraph (c) below, time standards for closing...

  9. 48 CFR 904.804-1 - Closeout by the office administering the contract.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... administering the contract. 904.804-1 Section 904.804-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL ADMINISTRATIVE MATTERS Government Contract Files 904.804-1 Closeout by the office administering the contract. (a) The Head of the Contracting Activity (HCA) shall ensure that...

  10. 25 CFR 171.110 - How does BIA administer its irrigation facilities?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How does BIA administer its irrigation facilities? 171.110 Section 171.110 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE General Provisions § 171.110 How does BIA administer its irrigation facilities?...

  11. 25 CFR 171.110 - How does BIA administer its irrigation facilities?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How does BIA administer its irrigation facilities? 171.110 Section 171.110 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE General Provisions § 171.110 How does BIA administer its...

  12. 25 CFR 171.110 - How does BIA administer its irrigation facilities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How does BIA administer its irrigation facilities? 171.110 Section 171.110 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE General Provisions § 171.110 How does BIA administer its...

  13. 25 CFR 171.110 - How does BIA administer its irrigation facilities?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How does BIA administer its irrigation facilities? 171.110 Section 171.110 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE General Provisions § 171.110 How does BIA administer its...

  14. 40 CFR 147.1053 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... on Indian lands in the State of Maryland is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS...

  15. 40 CFR 147.1053 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... on Indian lands in the State of Maryland is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS...

  16. 40 CFR 147.1053 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... on Indian lands in the State of Maryland is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS...

  17. 40 CFR 147.2551 - State-administered program-Class II wells.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... State of Wyoming, except those on Indian lands, is the program administered by the Wyoming Oil and Gas... Director of the OFR in accordance with 5 U.S.C. 552(a) and 1 CFR Part 51. Copies may be obtained at...

  18. 40 CFR 147.2551 - State-administered program-Class II wells.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... State of Wyoming, except those on Indian lands, is the program administered by the Wyoming Oil and Gas... Director of the OFR in accordance with 5 U.S.C. 552(a) and 1 CFR Part 51. Copies may be obtained at...

  19. Effects of Teacher- and Self-Administered Procedures on the Spelling Performance of Learning-Handicapped Children.

    ERIC Educational Resources Information Center

    Kapadia, E. Shireen; Fantuzzo, John W.

    1988-01-01

    Compared the relative effectiveness of teacher-administered and self-administered procedures on spelling for four educationally handicapped children using a modified reversal design. Found teacher- and self-administered interventions resulted in gains in performance, although self-administered procedures during treatment phases produced greater…

  20. Utilization of orally administered D-[14C]mannitol via fermentation by intestinal microbes in rats.

    PubMed

    Hongo, Ryoko; Nakamura, Sadako; Oku, Tsuneyuki

    2010-01-01

    To investigate the available energy of orally administered [(14)C]mannitol via intestinal microbes, [(14)C]mannitol (222 kBq, 105 mg) or [(14)C]glucose (222 kBq, 105 mg) was administered to conventional rats and antibiotics-treated rats whose intestinal microbes were depleted by drinking water containing antibiotics, respectively. The exhausted CO(2), feces and urine were then separately collected at 2, 4, 6, 8, 10, 12 and 24 h after administration of the test solution. In the conventional rats, 45% of administered radioactivity was recovered as (14)CO(2) in the administration of [(14)C]mannitol, while 57% of administered radioactivity was recovered as (14)CO(2) following the administration of [(14)C]glucose for 24 h. The time sequence for the (14)CO(2) excretion from [(14)C]mannitol was delayed as compared to [(14)C]glucose by about 4-6 h (p<0.05). However, when [(14)C]mannitol was orally administered to antibiotics-treated rats, only 3% of administered radioactivity was excreted as (14)CO(2) for 24 h. The total radioactivity of the gastrointestinal contents and feces for 24 h after administration was over 70%, much higher than those of the conventional rats (p<0.05). When a half dose (222 kBq, 52.5 mg) of [(14)C]mannitol was administered to conventional rats, the recovery as (14)CO(2) for 24 h (%) was significantly higher than that of a regular dose of [(14)C]mannitol (105 mg). When cold mannitol (105 mg) was orally administered to the antibiotics-treated rats, about 9% of intact mannitol was excreted in feces within 48 h after administration. However, no intact mannitol was detected in the conventional rats. These results demonstrate that more than 95% of mannitol administered orally is utilized via fermentation by intestinal microbes.

  1. 20 CFR 668.120 - How must INA programs be administered?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... WIA section 166(h)(1). (e) We will establish and maintain administrative procedures for the selection... this Act. We will utilize staff who have a particular competence in this field to administer...

  2. 30 CFR 250.1508 - What must I do when BSEE administers written or oral tests?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Well Control and Production Safety Training § 250.1508 What must I do when BSEE administers written or...

  3. 30 CFR 250.1508 - What must I do when BSEE administers written or oral tests?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Well Control and Production Safety Training § 250.1508 What must I do when BSEE administers written or...

  4. 30 CFR 250.1508 - What must I do when MMS administers written or oral tests?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Well Control and Production Safety Training § 250.1508 What must I do when MMS administers written or oral tests? MMS or...

  5. 30 CFR 250.1508 - What must I do when BSEE administers written or oral tests?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Well Control and Production Safety Training § 250.1508 What must I do when BSEE administers written or...

  6. Effects of orally administered bovine lactoperoxidase on dextran sulfate sodium-induced colitis in mice.

    PubMed

    Shin, Kouichirou; Horigome, Ayako; Yamauchi, Koji; Takase, Mitsunori; Yaeshima, Tomoko; Iwatsuki, Keiji

    2008-07-01

    The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening, and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.

  7. 25 CFR 166.603 - If cash is submitted as a bond, how is it administered?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false If cash is submitted as a bond, how is it administered? 166.603 Section 166.603 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Bonding and Insurance Requirements § 166.603 If cash is submitted as a bond, how is it administered? If cash is submitted as a bond,...

  8. Validation of a self-administered questionnaire for assessing occupational and environmental exposures of pregnant women

    SciTech Connect

    Eskenazi, B.; Pearson, K.

    1988-11-01

    The present investigation sought to determine whether a self-administered questionnaire could be used to obtain occupational information from pregnant women attending the obstetrical clinics at the University of California, San Francisco from July to November 1986. The authors compared the accuracy of responses of 57 women on the self-administered questionnaire with those obtained on a detailed clinical interview by an occupational health professional. The self-administered questionnaire and the clinical interview included information on the woman's job title, the type of company she worked for, the level of physical activity, her exposures on the job and at home, and her partner's occupation. The authors also examined whether the validity of the self-administered questionnaire could be improved on review by an industrial hygienist. The questionnaire took less than 20 minutes to complete, with over 90% of the women answering three-quarters of it. It was substantially accurate in obtaining information on number of hours worked during pregnancy, type of shift worked, and stress level in the workplace; exposure to radiation, video display terminals, fumes, gases, and cigarette smoke in the workplace; and exposure to pesticides, paint, and cigarette smoke at home. On those variables for which the responses on the self-administered questionnaire were less accurate, review by the industrial hygienist improved the level of accuracy considerably. These findings suggest that a self-administered questionnaire can be used to obtain valid information from pregnant women attending a prenatal clinic.

  9. Validation of interviewer- and self-administered physical activity checklists for fifth grade students.

    PubMed

    Sallis, J F; Strikmiller, P K; Harsha, D W; Feldman, H A; Ehlinger, S; Stone, E J; Williston, J; Woods, S

    1996-07-01

    The purpose of the study was to evaluate two physical activity recall instruments appropriate for use in epidemiologic studies of fifth grade children. The instruments were similar, except one (PACI) was administered in a personal interview, and the other (SAPAC) was self-completed in a group setting. Both forms required children to report the minutes during the previous day they spent in 21 common physical activities that represented a range of intensities, plus sedentary pursuits. To validate the recalls, children simultaneously wore an accelerometer (motion sensor) and a heart rate monitor for at least 8 h the day before the interview. Subjects were 55 boys and 70 girls from four regions of the United States. The Pearson correlation between the self- and interviewer-administered forms was 0.76 (P < 0.001). The interviewer-administered form correlated 0.51 (P < 0.001) with the heart rate index and 0.33 (P < 0.001) with the accelerometer score. The self-administered form correlated 0.57 (P < 0.001) with the heart rate index and 0.30 (P < 0.001) with the accelerometer score. It is concluded that both self-report forms received moderate support for their validity in all gender and ethnic subgroups. The self-administered format is more cost-effective. PMID:8832538

  10. Safety Evaluation of CNS Administered Biologics-Study Design, Data Interpretation, and Translation to the Clinic.

    PubMed

    Vuillemenot, Brian R; Korte, Sven; Wright, Teresa L; Adams, Eric L; Boyd, Robert B; Butt, Mark T

    2016-07-01

    Many central nervous system (CNS) diseases are inadequately treated by systemically administered therapies due to the blood brain barrier (BBB), which prevents achieving adequate drug concentrations at sites of action. Due to the increasing prevalence of neurodegenerative diseases and the inability of most systemically administered therapies to cross the BBB, direct CNS delivery will likely play an increasing role in treatment. Administration of large molecules, cells, viral vectors, oligonucleotides, and other novel therapies directly to the CNS via the subarachnoid space, ventricular system, or parenchyma overcomes this obstacle. Clinical experience with direct CNS administration of small molecule therapies suggests that this approach may be efficacious for the treatment of neurodegenerative disorders using biological therapies. Risks of administration into the brain tissue or cerebrospinal fluid include local damage from implantation of the delivery system and/or administration of the therapeutic and reactions affecting the CNS. Preclinical safety studies on CNS administered compounds must differentiate between the effects of the test article, the delivery device, and/or the vehicle, and assess exacerbations of reactions due to combinations of effects. Animal models characterized for safety assessment of CNS administered therapeutics have enabled human trials, but interpretation can be challenging. This manuscript outlines the challenges of preclinical intrathecal/intracerebroventricular/intraparenchymal studies, evaluation of results, considerations for special endpoints, and translation of preclinical findings to enable first-in-human trials. Recommendations will be made based on the authors' collective experience with conducting these studies to enable clinical development of CNS-administered biologics. PMID:27354708

  11. 26 CFR 1.457-9 - Effect on eligible plans when not administered in accordance with eligibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Effect on eligible plans when not administered... for Which Items of Gross Income Included § 1.457-9 Effect on eligible plans when not administered in... date on which the Commissioner notifies the State in writing that the plan is being administered in...

  12. 43 CFR 5.1 - Areas administered by U.S. Fish and Wildlife Service or National Park Service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Areas administered by U.S. Fish and... JURISDICTION OF THE DEPARTMENT OF THE INTERIOR § 5.1 Areas administered by U.S. Fish and Wildlife Service or... track made on any area administered by the U.S. Fish and Wildlife Service or the National Park...

  13. 43 CFR 5.1 - Areas administered by U.S. Fish and Wildlife Service or National Park Service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Areas administered by U.S. Fish and... JURISDICTION OF THE DEPARTMENT OF THE INTERIOR § 5.1 Areas administered by U.S. Fish and Wildlife Service or... track made on any area administered by the U.S. Fish and Wildlife Service or the National Park...

  14. Comparative Discussion on Psychophysiological Effect of Self-administered Facial Massage by Treatment Method

    NASA Astrophysics Data System (ADS)

    Nozawa, Akio; Takei, Yuya

    The aim of study was to quantitatively evaluate the effects of self-administered facial massage, which was done by hand or facial roller. In this study, the psychophysiological effects of facial massage were evaluated. The central nerves system and the autonomic nervous system were administered to evaluate physiological system. The central nerves system was assessed by Electroencephalogram (EEG). The autonomic nervous system were assessed by peripheral skin temperature(PST) and heart rate variability (HRV) with spectral analysis. In the spectral analysis of HRV, the high-frequency components (HF) were evaluated. State-Trait Anxiety Inventory (STAI), Profile of Mood Status (POMS) and subjective sensory amount with Visual Analog Scale (VAS) were administered to evaluate psychological status. These results suggest that kept brain activity and had strong effects on stress alleviation.

  15. Enhanced glucose tolerance by intravascularly administered piceatannol in freely moving healthy rats.

    PubMed

    Oritani, Yukihiro; Okitsu, Teru; Nishimura, Eisaku; Sai, Masahiko; Ito, Tatsuhiko; Takeuchi, Shoji

    2016-02-12

    Piceatannol is a phytochemical in the seeds of passion fruit that has a hypoglycemic effect when orally administered. To elucidate the contribution of intact and metabolites of piceatannol after gastro-intestinal absorption to hypoglycemic effect, we examined the influence of piceatannol and isorhapontigenin on blood glucose concentrations during fasting and glucose tolerance tests by administering them intravascularly to freely moving healthy rats. We found that intravascularly administered piceatannol reduced the blood glucose concentrations during both fasting and glucose tolerance tests, but isorhapontigenin did not during either of them. Furthermore, we found that piceatannol increased the insulinogenic index during glucose tolerance tests and that piceatannol had no influence on insulin sensitivity by performing hyperinsulinemic euglycemic clamping tests. These results suggest that piceatannol orally intaken may enhance glucose tolerance by the effect of intact piceatannol through enhanced early-phase secretion of insulin. Therefore, oral intake of piceatannol might contribute to proper control of postprandial glycemic excursions in healthy subjects.

  16. Disclosure of sensitive behaviors across self-administered survey modes: a meta-analysis.

    PubMed

    Gnambs, Timo; Kaspar, Kai

    2015-12-01

    In surveys, individuals tend to misreport behaviors that are in contrast to prevalent social norms or regulations. Several design features of the survey procedure have been suggested to counteract this problem; particularly, computerized surveys are supposed to elicit more truthful responding. This assumption was tested in a meta-analysis of survey experiments reporting 460 effect sizes (total N =125,672). Self-reported prevalence rates of several sensitive behaviors for which motivated misreporting has been frequently observed were compared across self-administered paper-and-pencil versus computerized surveys. The results revealed that computerized surveys led to significantly more reporting of socially undesirable behaviors than comparable surveys administered on paper. This effect was strongest for highly sensitive behaviors and surveys administered individually to respondents. Moderator analyses did not identify interviewer effects or benefits of audio-enhanced computer surveys. The meta-analysis highlighted the advantages of computerized survey modes for the assessment of sensitive topics.

  17. Progesterone, administered prior to kainic acid, reduces decrements in cognitive performance in the Morris Water Maze

    PubMed Central

    Frye, Cheryl A.; Walf, Alicia

    2013-01-01

    The nature of progesterone (P4)’s neuroprotective effects is of interest. We investigated effects of P4 when administered prior to, or following, kainic acid, which produces ictal activity and damage to the hippocampus, to mediate effects on spatial performance. The hypothesis was that P4, compared to vehicle, would reduce decrements in Morris Water Maze performance induced by kainic acid. Experiment 1: We examined the effects of kainic acid on plasma stress hormone, corticosterone, and progestogen (P4 and its metabolites) levels in plasma and the hippocampus following subcutaneous (s.c.) P4 administration to ovariectomized rats. Rats administered kainic acid had the highest corticosterone levels immediately following injection. P4 is 5α-reduced to dihydroprogesterone (DHP) and subsequently metabolized to 5α-pregnan-3α-ol-20-one (3α,5α-THP) by 3α-hydroxysteroid dehydrogenase. The regimen of P4 utilized produced circulating and hippocampal levels of P4, DHP, and 3α,5α-THP within a physiological range, which decline at 14 hours post-injection, and were not altered by kainic acid. Experiment 2: The physiological P4 regimen was administered to rats before, or following, kainic acid-induced seizures, and later effects on water maze performance were compared to that of rats administered vehicle. Rats administered kainic acid had significantly poorer performance in the water maze (i.e. increased latencies and distances to the hidden platform) than did rats administered vehicle. Administration of P4 before, but not after, kainic acid prevented these performance deficits. Thus, these data suggest that a physiological regimen of P4 can prevent some of the deficits in water maze performance produced by kainic acid. PMID:20715152

  18. Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers.

    PubMed

    Dodds Ashley, Elizabeth S; Varkey, Jay B; Krishna, Gopal; Vickery, Donna; Ma, Lei; Yu, Xin; Malavade, Darshana; Goodwin, Megan; Perfect, John R; Power, Eddie

    2009-07-01

    The use of a nasogastric tube is one means of administering antifungal therapy to critically ill patients unable to receive medication via the oral route. This was a phase 1, open-label, single-center, randomized, crossover study of posaconazole administered via nasogastric tube in healthy volunteers. Each subject received two 400-mg single doses of posaconazole, one administered orally and one administered by nasogastric tube, with a 7-day washout period between each dose. Posaconazole was administered 5 to 10 min after subjects received a nutritional supplement. Blood samples for pharmacokinetic analysis were obtained up to 120 h postdose. The analysis of variance estimate of the study population suggests that the posaconazole nasogastric tube administration least-square mean values of observed maximum concentration (C(max)), area under the plasma concentration-time curve (AUC) to the last measurable concentration, and AUC to time infinity were 81%, 76%, and 77%, respectively, of the corresponding oral administration values. The reason for lower C(max) and AUC values when posaconazole is administered via the nasogastric tube route is not known. Oral and nasogastric tube administration of a single 400-mg dose of posaconazole suspension was safe and well tolerated in healthy adult subjects. The incidence and nature of treatment-emergent adverse events were similar with both administration routes, and no serious adverse events or clinically significant laboratory test or vital sign abnormalities were reported. Obtaining plasma posaconazole concentrations may be warranted when posaconazole is given to patients via a nasogastric tube to ensure adequate posaconazole exposure. Strategies that have been shown to enhance posaconazole exposure (such as splitting the dose and minimizing the use of proton pump inhibitors) may also be used.

  19. Comparing administered and market-based water allocation systems using an agent-based modeling approach

    NASA Astrophysics Data System (ADS)

    Zhao, J.; Cai, X.; Wang, Z.

    2009-12-01

    It also has been well recognized that market-based systems can have significant advantages over administered systems for water allocation. However there are not many successful water markets around the world yet and administered systems exist commonly in water allocation management practice. This paradox has been under discussion for decades and still calls for attention for both research and practice. This paper explores some insights for the paradox and tries to address why market systems have not been widely implemented for water allocation. Adopting the theory of agent-based system we develop a consistent analytical model to interpret both systems. First we derive some theorems based on the analytical model, with respect to the necessary conditions for economic efficiency of water allocation. Following that the agent-based model is used to illustrate the coherence and difference between administered and market-based systems. The two systems are compared from three aspects: 1) the driving forces acting on the system state, 2) system efficiency, and 3) equity. Regarding economic efficiency, penalty on the violation of water use permits (or rights) under an administered system can lead to system-wide economic efficiency, as well as being acceptable by some agents, which follows the theory of the so-call rational violation. Ideal equity will be realized if penalty equals incentive with an administered system and if transaction costs are zero with a market system. The performances of both agents and the over system are explained with an administered system and market system, respectively. The performances of agents are subject to different mechanisms of interactions between agents under the two systems. The system emergency (i.e., system benefit, equilibrium market price, etc), resulting from the performance at the agent level, reflects the different mechanism of the two systems, the “invisible hand” with the market system and administrative measures (penalty

  20. 20 CFR 641.610 - How are pilot, demonstration, and evaluation projects administered?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false How are pilot, demonstration, and evaluation projects administered? 641.610 Section 641.610 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION..., and Evaluation Projects § 641.610 How are pilot, demonstration, and evaluation projects...

  1. 20 CFR 641.610 - How are pilot, demonstration, and evaluation projects administered?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false How are pilot, demonstration, and evaluation projects administered? 641.610 Section 641.610 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION..., and Evaluation Projects § 641.610 How are pilot, demonstration, and evaluation projects...

  2. 20 CFR 641.610 - How are pilot, demonstration, and evaluation projects administered?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false How are pilot, demonstration, and evaluation projects administered? 641.610 Section 641.610 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION..., and Evaluation Projects § 641.610 How are pilot, demonstration, and evaluation projects...

  3. 20 CFR 641.610 - How are pilot, demonstration, and evaluation projects administered?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false How are pilot, demonstration, and evaluation projects administered? 641.610 Section 641.610 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION..., and Evaluation Projects § 641.610 How are pilot, demonstration, and evaluation projects...

  4. 40 CFR 272.701 - State-administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51 as part of the hazardous waste management... 40 Protection of Environment 28 2013-07-01 2013-07-01 false State-administered program: Final authorization. 272.701 Section 272.701 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

  5. 40 CFR 272.1301 - State-administered program; Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false State-administered program; Final authorization. 272.1301 Section 272.1301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Missouri § 272.1301...

  6. 40 CFR 272.2501 - Wisconsin State-administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Wisconsin State-administered program: Final authorization. 272.2501 Section 272.2501 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Wisconsin §...

  7. 40 CFR 272.151 - Arizona State-administered program: Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Arizona State-administered program: Final authorization. 272.151 Section 272.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona §...

  8. 40 CFR 272.651 - Idaho State-Administered Program: Final Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Idaho State-Administered Program: Final Authorization. 272.651 Section 272.651 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Idaho § 272.651...

  9. 40 CFR 272.401 - State-administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false State-administered program: Final authorization. 272.401 Section 272.401 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Delaware § 272.401...

  10. 40 CFR 272.2251 - Utah State-Administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Utah State-Administered program: Final authorization. 272.2251 Section 272.2251 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Utah § 272.2251 Utah...

  11. 40 CFR 272.1301 - State-administered program; Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false State-administered program; Final authorization. 272.1301 Section 272.1301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Missouri § 272.1301...

  12. 40 CFR 272.501 - Florida State-administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .../92 Recycled Used Oil Management Standards (Checklist 112) 57 FR 41566: Amendments to 40 CFR Parts 260... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Florida State-administered program: Final authorization. 272.501 Section 272.501 Protection of Environment ENVIRONMENTAL PROTECTION...

  13. 40 CFR 272.1351 - Montana State-Administered Program: Final Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Montana State-Administered Program: Final Authorization. 272.1351 Section 272.1351 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Montana §...

  14. 40 CFR 272.1801 - State-administered program: Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false State-administered program: Final authorization. 272.1801 Section 272.1801 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Ohio § 272.1801...

  15. 40 CFR 272.951 - Louisiana state-administered Program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Louisiana state-administered Program: Final authorization. 272.951 Section 272.951 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Louisiana §...

  16. 40 CFR 272.701 - State-administered program: Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51 as part of the hazardous waste management... 40 Protection of Environment 28 2012-07-01 2012-07-01 false State-administered program: Final authorization. 272.701 Section 272.701 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

  17. 40 CFR 272.951 - Louisiana state-administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Louisiana state-administered program: Final authorization. 272.951 Section 272.951 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Louisiana §...

  18. 40 CFR 272.401 - State-administered program: Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false State-administered program: Final authorization. 272.401 Section 272.401 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Delaware § 272.401...

  19. 40 CFR 272.1801 - State-administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false State-administered program: Final authorization. 272.1801 Section 272.1801 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Ohio § 272.1801...

  20. 40 CFR 272.151 - Arizona State-administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Arizona State-administered program: Final authorization. 272.151 Section 272.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arizona §...

  1. 50 CFR 86.115 - How should I administer the survey?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (BIG) PROGRAM How States Will Complete Access Needs Surveys § 86.115 How should I administer the survey... methodology to collect data, which may include telephone, mail, fax, or other inventory means. We do not expect you to use automated, electronic, mechanical, or similar means of information collection. (d)...

  2. 50 CFR 86.115 - How should I administer the survey?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (BIG) PROGRAM How States Will Complete Access Needs Surveys § 86.115 How should I administer the survey... methodology to collect data, which may include telephone, mail, fax, or other inventory means. We do not expect you to use automated, electronic, mechanical, or similar means of information collection. (d)...

  3. 45 CFR 400.65 - Continuation of a publicly-administered RCA program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... program. 400.65 Section 400.65 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Refugee Cash Assistance § 400.65 Continuation of a publicly-administered RCA...

  4. [Distribution of orally administered aflatoxin B 1 in the tissues and organs of the goat (Capra)].

    PubMed

    Veselý, D; Veselá, D; Kusák, V; Nesnídal, P

    1978-09-01

    In the experiment the goat was administered an amount of 450 mg aflatoxin B1. The milk taken during the experiment was lyophilized and aflatoxins B1 and M1 were isolated. After the death of the goat some tissues, blood and bile of the experimental animal were analyzed to find out the aflatoxin content.

  5. 40 CFR 147.2205 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements of 40 CFR parts 124, 144, 146, 148, and any additional requirements set forth in the remainder of.... 147.2205 Section 147.2205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER....2205 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells...

  6. DEVELOPMENTAL EFFECTS OF TRICHLOROACETONITRILE ADMINISTERED IN CORN OIL TO PREGNANT LONG-EVANS RATS

    EPA Science Inventory

    Trichloroacetonitrile (TCAN) is a by-product of the chlorine disinfection of water containing natural organic material. When administered by gavage to pregnant Long-Evans rats in a medium-chain triglyceride vehicle, tricaprylin oil (Tricap), at a volume of 10 ml/kg, TCAN induced ...

  7. 40 CFR 147.52 - State-administered program-Hydraulic Fracturing of Coal Beds.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) The Program Description for the Regulation of Hydraulic Fracturing of Coal Beds As required by 40 CFR... PROGRAMS Alabama § 147.52 State-administered program—Hydraulic Fracturing of Coal Beds. The UIC program for hydraulic fracturing of coal beds in the State of Alabama, except those on Indian lands, is the...

  8. 40 CFR 147.2404 - EPA-administered program-Colville Reservation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CFR part 124, 144 and 146 and any additional requirements set forth in the remainder of this subpart...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... shall plug and abandon the well according to the approved plan and schedule....

  9. 40 CFR 147.2404 - EPA-administered program-Colville Reservation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CFR part 124, 144 and 146 and any additional requirements set forth in the remainder of this subpart...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... shall plug and abandon the well according to the approved plan and schedule....

  10. 40 CFR 147.2404 - EPA-administered program-Colville Reservation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CFR part 124, 144 and 146 and any additional requirements set forth in the remainder of this subpart...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... shall plug and abandon the well according to the approved plan and schedule....

  11. 40 CFR 147.2404 - EPA-administered program-Colville Reservation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CFR part 124, 144 and 146 and any additional requirements set forth in the remainder of this subpart...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... shall plug and abandon the well according to the approved plan and schedule....

  12. 40 CFR 147.2404 - EPA-administered program-Colville Reservation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CFR part 124, 144 and 146 and any additional requirements set forth in the remainder of this subpart...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... shall plug and abandon the well according to the approved plan and schedule....

  13. 40 CFR 147.1400 - State-administered program-Class II wells.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... State of Nebraska, except those on Indian lands, is the program administered by the Nebraska Oil and Gas..., 1984. (1) Rules and Regulations of the Nebraska Oil and Gas Conservation Commission, Rules 1 through 6...-906 (Reissue 1988). (b) Other laws. The following statutes and regulations, although not...

  14. 40 CFR 147.1400 - State-administered program-Class II wells.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... State of Nebraska, except those on Indian lands, is the program administered by the Nebraska Oil and Gas..., 1984. (1) Rules and Regulations of the Nebraska Oil and Gas Conservation Commission, Rules 1 through 6...-906 (Reissue 1988). (b) Other laws. The following statutes and regulations, although not...

  15. Testing Adult Basic Education Students for Reading Ability and Progress: How Many Tests to Administer?

    ERIC Educational Resources Information Center

    Greenberg, Daphne; Levy, Susan R.; Rasher, Sue; Kim, Yoonsang; Carter, Sarah Deardorff; Berbaum, Michael L.

    2010-01-01

    This study examines the relationship between TABE-R performance and performance on selected, more focused reading component tests after 42 hours of adult education classroom instruction. Specifically, measures of expressive vocabulary, reading fluency, sight word reading, and decoding were administered to 98 participants along with the TABE-R.…

  16. Depression in People with Intellectual Disability: An Evaluation of a Staff-Administered Treatment Program

    ERIC Educational Resources Information Center

    McGillivray, Jane A.; McCabe, Marita P.; Kershaw, Mavis M.

    2008-01-01

    The prevalence of co-morbid depression in people with intellectual disability (ID) provides a strong rationale for the early identification and treatment of individuals at risk. The aim of this study was to evaluate a staff-administered group CBT program for the treatment of depression in people with mild ID. A sample of 13 staff employed at two…

  17. 78 FR 23777 - Notice of Proposed Information Collection: Comment Request: HUD-Administered Small Cities Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... recipients participating in the HUD administered CDBG program provides HUD with financial and physical... technology, e.g., permitting electronic submission of responses. This notice also lists the following... program provides HUD with financial and physical development status of each activity funded. These...

  18. Employing Computer-Administered Exams in General Psychology: Student Anxiety and Expectations

    ERIC Educational Resources Information Center

    Schult, Carolyn A.; McIntosh, John L.

    2004-01-01

    Computer-administered exams offer many advantages, but instructors may be reluctant to use them due to concerns that computer anxiety may increase student test anxiety. Introductory psychology students (N = 265) completed surveys prior to their first exam about their anxiety related to the upcoming exam, computers in general, and taking exams on…

  19. 40 CFR 282.98 - West Virginia State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... it more stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281... 40 Protection of Environment 26 2010-07-01 2010-07-01 false West Virginia State-Administered... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.98...

  20. Stress Management for Special Educators: The Self-Administered Tool for Awareness and Relaxation (STAR)

    ERIC Educational Resources Information Center

    Williams, Krista; Poel, Elissa Wolfe

    2006-01-01

    The Self-Administered Tool for Awareness and Relaxation (STAR) is a stress management strategy designed to facilitate awareness of the physical, mental, emotional, and physiological effects of stress through the interconnectedness of the brain, body, and emotions. The purpose of this article is to present a stress-management model for teachers,…

  1. The Assessment of Role Identity: Problems of Administering the Instrumental Activities Inventory to Inuit Children.

    ERIC Educational Resources Information Center

    McElroy, Ann

    A modified version of the Instrumental Activities Inventory (IAI) was administered to a sample of Canadian Inuit children (41 girls and 37 boys aged 9 to 17 from Frobisher Bay and 40 boys and 35 girls aged 8 to 16 from Pangnirtung) for purposes of assessing role model preferences relative to the socialization process. Consisting of 12 female and…

  2. 9 CFR 103.2 - Disposition of animals administered experimental biological products or live organisms.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Disposition of animals administered experimental biological products or live organisms. 103.2 Section 103.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND...

  3. 9 CFR 103.2 - Disposition of animals administered experimental biological products or live organisms.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Disposition of animals administered experimental biological products or live organisms. 103.2 Section 103.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND...

  4. 9 CFR 103.2 - Disposition of animals administered experimental biological products or live organisms.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Disposition of animals administered experimental biological products or live organisms. 103.2 Section 103.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND...

  5. 9 CFR 103.2 - Disposition of animals administered experimental biological products or live organisms.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Disposition of animals administered experimental biological products or live organisms. 103.2 Section 103.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND...

  6. 24 CFR 511.50 - State election to administer a rental rehabilitation program.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... rental rehabilitation program. 511.50 Section 511.50 Housing and Urban Development Regulations Relating... GRANT PROGRAM State Program § 511.50 State election to administer a rental rehabilitation program. (a) State allocations may be used to carry out eligible rehabilitation activities in accordance with...

  7. 24 CFR 511.50 - State election to administer a rental rehabilitation program.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false State election to administer a rental rehabilitation program. 511.50 Section 511.50 Housing and Urban Development Regulations...

  8. 24 CFR 511.50 - State election to administer a rental rehabilitation program.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false State election to administer a rental rehabilitation program. 511.50 Section 511.50 Housing and Urban Development Regulations...

  9. 24 CFR 511.50 - State election to administer a rental rehabilitation program.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true State election to administer a rental rehabilitation program. 511.50 Section 511.50 Housing and Urban Development Regulations...

  10. 76 FR 72211 - Notice of Proposed Information Collection: Comment Request, HUD-Administered Small Cities Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... URBAN DEVELOPMENT Notice of Proposed Information Collection: Comment Request, HUD- Administered Small... be sent to: William Kelleher, Reports Liaison Officer, Department of Housing and Urban Development... previously approved collection for which approval has expired, and a request for OMB renewal for three...

  11. 24 CFR 511.50 - State election to administer a rental rehabilitation program.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL RENTAL REHABILITATON... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false State election to administer a rental rehabilitation program. 511.50 Section 511.50 Housing and Urban Development Regulations...

  12. BIOAVAILABILITY AND BIOLOGICAL RESPONSE OF PBDES ADMINISTERED TO RATS IN HOUSEHOLD DUST

    EPA Science Inventory

    Abstract Household dust has recently been implicated as a source of PBDE exposure. This study investigated the bioavailability of PBDEs in house dust administered through the diet as compared to PBDEs in oil via the diet. PBDEs in household dust were just as bioavailabl...

  13. Preliminary Reliability and Validity of the Clinician-Administered PTSD Scale for Schizophrenia

    ERIC Educational Resources Information Center

    Gearon, Jean S.; Bellack, Alan S.; Tenhula, Wendy N.

    2004-01-01

    This study provides preliminary psychometric support for a version of the Clinician-Administered Posttraumatic Stress Disorder (PTSD) Scale (CAPS; D. D. Blake et al., 1990) adapted for use with patients with schizophrenia (CAPS-S; J. S. Gearon. S. Thomas-Lohrman, & A. S. Bellack, 2001). Nineteen women with schizophrenia and co-occurring illicit…

  14. 43 CFR 420.25 - Reclamation lands administered by other agencies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for management of Reclamation lands for recreation purposes. Specifically: (1) Reclamation lands managed by the National Park Service, the Bureau of Sport Fisheries and Wildlife, the Bureau of Land Management, the Forest Service, and other Federal agencies will be administered in accordance...

  15. 76 FR 71830 - Defense Federal Acquisition Regulation Supplement: Administering Trafficking in Persons...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Regulation Supplement: Administering Trafficking in Persons Regulations (DFARS Case 2011-D051) AGENCY... compliance with duties and responsibilities pertaining to trafficking in persons when they are incorporated... Trafficking in Persons, in all solicitations and contracts. When the contract will be performed outside...

  16. 40 CFR 282.102 - Puerto Rico State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... program which make it more stringent, in accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Puerto Rico State-Administered Program... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.102...

  17. 40 CFR 272.2101 - South Dakota State-Administered Program: Final Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Program: Final Authorization. 272.2101 Section 272.2101 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS South Dakota § 272.2101 South Dakota State-Administered Program: Final Authorization. (a) Pursuant to...

  18. Telephone-Administered Cognitive Behavioral Therapy for Veterans Served by Community-Based Outpatient Clinics

    ERIC Educational Resources Information Center

    Mohr, David C.; Carmody, Timothy; Erickson, Lauren; Jin, Ling; Leader, Julie

    2011-01-01

    Objective: Multiple trials have found telephone-administered cognitive behavioral therapy (T-CBT) to be effective for the treatment of depression. The aim of this study was to evaluate T-CBT for the treatment of depression among veterans served by community-based outpatient clinics (CBOCs) outside of major urban areas. Method: Eighty-five veterans…

  19. 40 CFR 147.1603 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... on Indian lands in New Mexico, except for Class II wells on Navajo Indian lands for which EPA has... effective date for the UIC program on Indian lands in New Mexico, except for Class II wells on Navajo Indian... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program-Indian...

  20. 40 CFR 147.2253 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Indian lands in the State of Utah, except for Class II wells on Navajo Indian lands for which EPA has... administered by EPA. The program for wells on Navajo Indian lands, except for Class II wells on Navajo Indian... wells on Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148,...

  1. 40 CFR 147.1603 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... on Indian lands in New Mexico, except for Class II wells on Navajo Indian lands for which EPA has... effective date for the UIC program on Indian lands in New Mexico, except for Class II wells on Navajo Indian... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program-Indian...

  2. 40 CFR 147.2253 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Indian lands in the State of Utah, except for Class II wells on Navajo Indian lands for which EPA has... administered by EPA. The program for wells on Navajo Indian lands, except for Class II wells on Navajo Indian... wells on Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148,...

  3. 40 CFR 147.1603 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... on Indian lands in New Mexico, except for Class II wells on Navajo Indian lands for which EPA has... effective date for the UIC program on Indian lands in New Mexico, except for Class II wells on Navajo Indian... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program-Indian...

  4. 40 CFR 147.2253 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Indian lands in the State of Utah, except for Class II wells on Navajo Indian lands for which EPA has... administered by EPA. The program for wells on Navajo Indian lands, except for Class II wells on Navajo Indian... wells on Indian lands consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148,...

  5. Validity of a Self-Administered 3-Day Physical Activity Recall in Young Adults

    ERIC Educational Resources Information Center

    Han, Jennifer L.; Dinger, Mary K.

    2009-01-01

    Background: Most physical activity recall questionnaires assess activity over a 7-day period. However, questionnaires have been validated in adolescents and adults using shorter recall timeframes. Purpose: The purpose of this study was to assess the validity of a self-administered 3-day physical activity recall instrument (3DR) in young adults.…

  6. 34 CFR 650.41 - How are institutional payments to be administered?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Consumer Price Index for the previous calendar year. (b) If the institution of higher education charges and... 34 Education 3 2010-07-01 2010-07-01 false How are institutional payments to be administered? 650.41 Section 650.41 Education Regulations of the Offices of the Department of Education...

  7. 41 CFR 302-14.100 - How should we administer our home marketing incentive payment program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false How should we administer our home marketing incentive payment program? 302-14.100 Section 302-14.100 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RESIDENCE TRANSACTION...

  8. 41 CFR 302-14.100 - How should we administer our home marketing incentive payment program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false How should we administer our home marketing incentive payment program? 302-14.100 Section 302-14.100 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RESIDENCE TRANSACTION...

  9. 41 CFR 302-14.100 - How should we administer our home marketing incentive payment program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false How should we administer our home marketing incentive payment program? 302-14.100 Section 302-14.100 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RESIDENCE TRANSACTION...

  10. 41 CFR 302-14.100 - How should we administer our home marketing incentive payment program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true How should we administer our home marketing incentive payment program? 302-14.100 Section 302-14.100 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RESIDENCE TRANSACTION...

  11. 41 CFR 302-14.100 - How should we administer our home marketing incentive payment program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false How should we administer our home marketing incentive payment program? 302-14.100 Section 302-14.100 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RESIDENCE TRANSACTION...

  12. Social Desirability Responding on World Wide Web and Paper-Administered Surveys.

    ERIC Educational Resources Information Center

    Hancock, Dawson R.; Flowers, Claudia P.

    Social desirability responding (SDR) on surveys administered on the World Wide Web and on paper was examined, with 178 graduate and undergraduate students as participants. To assess the extent to which participants would demonstrate SDR, this study used the Balanced Inventory of Desirable Responding (BIDR) (Paulhus, 1993). The BIDR consists of 40…

  13. Measurement Precision of the Clinician Administered PTSD Scale (CAPS): A RASCH Model Analysis.

    ERIC Educational Resources Information Center

    Betemps, Elizabeth J.; Smith, Richard M.; Baker, Dewleen G.; Rounds-Kugler, Barbara A.

    2003-01-01

    Analyzed the Frequency and Intensity subscales of the Clinician Administered Posttraumatic Stress Disorder Scale (PTSD) separately using a Rasch rating scale model. The Frequency subscale produced measures that encompassed the level of severity found in the sample of 201 veterans. (SLD)

  14. 40 CFR 282.81 - New Mexico State-Administered Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... accordance with section 9004 of RCRA, 42 U.S.C. 6991c, and 40 CFR part 281, subpart E. If New Mexico obtains... 40 Protection of Environment 26 2010-07-01 2010-07-01 false New Mexico State-Administered Program... WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.81 New...

  15. 40 CFR 147.1603 - EPA-administered program-Indian lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS New Mexico... on Indian lands in New Mexico, except for Class II wells on Navajo Indian lands for which EPA has... effective date for the UIC program on Indian lands in New Mexico, except for Class II wells on Navajo...

  16. 40 CFR 272.2201 - Texas State-Administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies of the Texas regulations that are incorporated by... this material at NARA, call 202-741-6030, or go to: http://www.archives.gov/federal-register/cfr/ibr... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Texas State-Administered...

  17. 40 CFR 272.2201 - Texas State-Administered program: Final authorization.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies of the Texas regulations that are incorporated by... this material at NARA, call 202-741-6030, or go to: http://www.archives.gov/federal-register/cfr/ibr... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Texas State-Administered...

  18. 45 CFR 400.65 - Continuation of a publicly-administered RCA program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... program. 400.65 Section 400.65 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Refugee Cash Assistance § 400.65 Continuation of a publicly-administered RCA...

  19. 34 CFR 650.42 - How are stipends to be administered?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false How are stipends to be administered? 650.42 Section 650.42 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Are the...

  20. 34 CFR 650.42 - How are stipends to be administered?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false How are stipends to be administered? 650.42 Section 650.42 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Are the...

  1. 34 CFR 650.42 - How are stipends to be administered?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false How are stipends to be administered? 650.42 Section 650.42 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Are the...

  2. Improving the Estimation of Moderating Effects by Using Computer-Administered Questionnaires.

    ERIC Educational Resources Information Center

    Aguinis, Herman; And Others

    1996-01-01

    A program designed to administer questionnaires on IBM and IBM-compatible personal computers is described. The program prompts subjects to indicate responses by clicking on a graphic line segment or entering a numeric value. The program enhances accuracy in estimating moderating effects by overcoming transcriptional errors and scale coarseness.…

  3. Staff-Administered Functional Analysis and Treatment of Aggression by an Elder with Dementia

    ERIC Educational Resources Information Center

    Baker, Jonathan C.; Hanley, Gregory P.; Mathews, R. Mark

    2006-01-01

    In the current study, nursing home staff were taught to administer functional analyses to determine the variables maintaining aggression by an elder with dementia. The results indicated that aggression was evoked during bathroom routines and that escape maintained aggression. Staff then reduced aggression to near-zero levels with noncontingent…

  4. 24 CFR 570.497 - Condition of State election to administer State CDBG Program.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Condition of State election to administer State CDBG Program. 570.497 Section 570.497 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING...

  5. Project IMPACT: Computer-Administered Instruction: Description of the Hardware/Software Subsystem. Technical Report.

    ERIC Educational Resources Information Center

    Human Resources Research Organization, Alexandria, VA.

    Project IMPACT (Instructional Model Prototypes Attainable in Computerized Training) is a comprehensive advanced development project designed to produce an effective and economical computer-administered instruction (CAI) system for the Army. The computer hardware and software capabilities of the prototype system are described. The components of the…

  6. Teacher Variations when Administering Math Graphics Items to Students with Visual Impairments

    ERIC Educational Resources Information Center

    Schoch, Christina Sigrid

    2010-01-01

    This exploratory study investigated the techniques used by teachers of the visually impaired when administering math questions with graphics to students with blindness or low vision. The researcher observed and videotaped 10 pairs of students with visual impairments and their teachers while the students were taking a test that consisted of 12…

  7. 42 CFR 447.520 - FFP: Conditions relating to physician-administered drugs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false FFP: Conditions relating to physician-administered drugs. 447.520 Section 447.520 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment for Drugs § 447.520 FFP: Conditions relating...

  8. Psychomotor and Motor Speed in Power Athletes Self-Administering Testosterone and Anabolic Steroids.

    ERIC Educational Resources Information Center

    Era, Pertti; And Others

    1988-01-01

    Self-administered testosterone and anabolic steroids resulted in insignificant improvement in psychomotor and motor speed tests of power athletes. This study is part of a larger study on the effects of such drugs on endocrinology, metabolism and neuromuscular functions. Methodolgy and results are discussed. (Author/JL)

  9. 40 CFR 147.1401 - State administered program-Class I, III, IV and V wells.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Injection and Mineral Production Wells, Effective Date: February 16, 1982, Amended Dates: November 12, 1983..., III, IV and V wells. 147.1401 Section 147.1401 Protection of Environment ENVIRONMENTAL PROTECTION... CONTROL PROGRAMS Nebraska § 147.1401 State administered program—Class I, III, IV and V wells. The...

  10. 40 CFR 147.1401 - State administered program-Class I, III, IV and V wells.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Injection and Mineral Production Wells, Effective Date: February 16, 1982, Amended Dates: November 12, 1983..., III, IV and V wells. 147.1401 Section 147.1401 Protection of Environment ENVIRONMENTAL PROTECTION... CONTROL PROGRAMS Nebraska § 147.1401 State administered program—Class I, III, IV and V wells. The...

  11. 40 CFR 147.1401 - State administered program-Class I, III, IV and V wells.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Injection and Mineral Production Wells, Effective Date: February 16, 1982, Amended Dates: November 12, 1983..., III, IV and V wells. 147.1401 Section 147.1401 Protection of Environment ENVIRONMENTAL PROTECTION... CONTROL PROGRAMS Nebraska § 147.1401 State administered program—Class I, III, IV and V wells. The...

  12. 40 CFR 147.1401 - State administered program-Class I, III, IV and V wells.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Injection and Mineral Production Wells, Effective Date: February 16, 1982, Amended Dates: November 12, 1983..., III, IV and V wells. 147.1401 Section 147.1401 Protection of Environment ENVIRONMENTAL PROTECTION... CONTROL PROGRAMS Nebraska § 147.1401 State administered program—Class I, III, IV and V wells. The...

  13. 40 CFR 147.1401 - State administered program-Class I, III, IV and V wells.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Injection and Mineral Production Wells, Effective Date: February 16, 1982, Amended Dates: November 12, 1983..., III, IV and V wells. 147.1401 Section 147.1401 Protection of Environment ENVIRONMENTAL PROTECTION... CONTROL PROGRAMS Nebraska § 147.1401 State administered program—Class I, III, IV and V wells. The...

  14. Cataloging, Processing, Administering AV Materials. A Model for Wisconsin Schools. Revised, 1974.

    ERIC Educational Resources Information Center

    Little, Robert David, Ed.; And Others

    The Wisconsin Association of School Librarians has produced a manual for standardized processing of all nonprint media, based on two principles: (1) the media should be centralized, organized, and administered for maximum access; and (2) content is more important than form. Definitions, cataloging, processing, housing, circulation, and care are…

  15. 41 CFR 302-6.300 - How should we administer the TQSE allowance?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the TQSE allowance? 302-6.300 Section 302-6.300 Public Contracts and Property Management Federal... SUBSISTENCE AND TRANSPORTATION EXPENSES 6-ALLOWANCE FOR TEMPORARY QUARTERS SUBSISTENCE EXPENSES Agency Responsibilities § 302-6.300 How should we administer the TQSE allowance? Temporary quarters should be used only...

  16. Higher Education in Federally Administered Tribal Areas of Pakistan after 9/11: Problems and Prospects

    ERIC Educational Resources Information Center

    Ahmad, Syed Hafeez; Junaid, Fatima A.

    2010-01-01

    The troubled state of affairs in the Federally Administered Tribal Areas (FATA) of Pakistan portends serious repercussions and grave consequences, destined to affect education particularly higher education in the entire tribal belt. Ironically, no extensive study has been conducted, to investigate those dimensions of FATA higher education which…

  17. 42 CFR 2a.5 - Contents of application; research projects in which drugs will be administered.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Contents of application; research projects in which drugs will be administered. 2a.5 Section 2a.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH... (21 U.S.C. 872(d)) and 21 CFR 1316.22. If the request is in such form, and is supported by...

  18. 22 CFR 196.2 - How is the Fellowship Program administered?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship...

  19. 22 CFR 196.2 - How is the Fellowship Program administered?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship...

  20. 22 CFR 196.2 - How is the Fellowship Program administered?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship...

  1. 22 CFR 196.2 - How is the Fellowship Program administered?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship...

  2. 22 CFR 196.2 - How is the Fellowship Program administered?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship...

  3. 25 CFR 166.603 - If cash is submitted as a bond, how is it administered?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false If cash is submitted as a bond, how is it administered... GRAZING PERMITS Bonding and Insurance Requirements § 166.603 If cash is submitted as a bond, how is it... retain it....

  4. 45 CFR 1180.52 - The grantee administers or supervises the grant.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false The grantee administers or supervises the grant. 1180.52 Section 1180.52 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES INSTITUTE OF MUSEUM AND LIBRARY SERVICES GRANTS REGULATIONS...

  5. An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles

    NASA Astrophysics Data System (ADS)

    Smith, Nicole M.; Gachulincova, Ivana; Ho, Diwei; Bailey, Charlotte; Bartlett, Carole A.; Norret, Marck; Murphy, John; Buckley, Alysia; Rigby, Paul J.; House, Michael J.; St. Pierre, Timothy; Fitzgerald, Melinda; Iyer, K. Swaminathan; Dunlop, Sarah A.

    2016-03-01

    The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenously administered nanoparticles to the brain. Breakdown of the barrier occurs as a consequence of cerebrovascular diseases and traumatic brain injury. In this article, we report that remote injuries in the CNS are also associated with BBB dysfunction. In particular, we show that a focal partial transection of the optic nerve triggers a previously unknown transient opening of the mammalian BBB that occurs in the visual centres. Importantly, we demonstrate that this transient BBB breakdown results in a dramatic change in the biodistribution of intravenously administered large polymeric nanoparticles which were previously deemed as BBB-impermeable.

  6. Subchronic dispositional and toxicological effects of arsenate administered in drinking water to mice

    SciTech Connect

    Hughes, M.F.; Thompson, D.J.

    1996-10-11

    Exposure to the drinking water contaminant arsenate is a daily occurrence and there are concerns that this exposure may lead to cancer. Although the acute dispositional effects of arsenate have been studied in detail, there is minimal information on the disposition and toxicological effects of it after continuous exposure. The objective of this study was to examine in mice the effect of a 4-wk treatment with arsenate administered in drinking water. Female B6C3F1 mice were housed in metabolism cages and given water and food ad libitum. Two groups (A,B) of mice were treated with distilled water or water containing 0.025 mg/L (L) or 2.5 mg/L (H) arsenate. Several toxicological effects were observed in animals administered arsenate in drinking water, but no changes in the disposition of this arsenical were detected at the doses used in this study. 86 refs., 4 figs., 7 tabs.

  7. Creation of a registered nurse-administered nitrous oxide sedation program for radiology and beyond.

    PubMed

    Farrell, Mary Kay; Drake, Gloria J; Rucker, Denise; Finkelstein, Marsha; Zier, Judith L

    2008-01-01

    Children undergoing urethral catheterization for urologic imaging under existing sedation practices were identified as an underserved patient population. Using a multidisciplinary approach, a registered nurse (RN)-administered nitrous oxide sedation program was developed to meet the needs of these children. Program development required delineation of RN scope of practice, evaluation of equipment, formulation of an educational program, and compliance with occupational safety standards. The program was implemented in 2004 using standard "dental" nitrous oxide equipment coupled with distraction and imagery to enhance the efficacy of the sedation experience. Initial assessment via telephone questionnaire indicated fewer adverse effects and more rapid return to baseline than oral midazolam, the sedative previously used for these procedures. Ongoing evaluation continues to confirm patient and environmental safety. The nitrous oxide program has expanded to provide sedation for additional tests in radiology as well as in other hospital departments. By implementing an RN-administered nitrous oxide program, children's access to this sedative/analgesic agent is increased.

  8. An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles

    PubMed Central

    Smith, Nicole M.; Gachulincova, Ivana; Ho, Diwei; Bailey, Charlotte; Bartlett, Carole A.; Norret, Marck; Murphy, John; Buckley, Alysia; Rigby, Paul J.; House, Michael J.; St. Pierre, Timothy; Fitzgerald, Melinda; Iyer, K. Swaminathan; Dunlop, Sarah A.

    2016-01-01

    The highly restrictive blood-brain barrier (BBB) plays a critically important role in maintaining brain homeostasis and is pivotal for proper neuronal function. The BBB is currently considered the main limiting factor restricting the passage of large (up to 200 nm) intravenously administered nanoparticles to the brain. Breakdown of the barrier occurs as a consequence of cerebrovascular diseases and traumatic brain injury. In this article, we report that remote injuries in the CNS are also associated with BBB dysfunction. In particular, we show that a focal partial transection of the optic nerve triggers a previously unknown transient opening of the mammalian BBB that occurs in the visual centres. Importantly, we demonstrate that this transient BBB breakdown results in a dramatic change in the biodistribution of intravenously administered large polymeric nanoparticles which were previously deemed as BBB-impermeable. PMID:26940762

  9. A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells.

    PubMed

    Wang, Haolu; Liang, Xiaowen; Xu, Zhi Ping; Crawford, Darrell H G; Liu, Xin; Roberts, Michael S

    2016-01-01

    Although mesenchymal stem cells (MSCs) present a promising tool in cell therapy for the treatment of various diseases, the in vivo distribution of administered MSCs has still been poorly understood, which hampers the precise prediction and evaluation of their therapeutic efficacy. Here, we developed the first model to characterize the physiological kinetics of administered MSCs based on direct visualization of cell spatiotemporal disposition by intravital microscopy and assessment of cell quantity using flow cytometry. This physiologically based kinetic model was validated with multiple external datasets, indicating potential inter-route and inter-species predictive capability. Our results suggest that the targeting efficiency of MSCs is determined by the lung retention and interaction between MSCs and target organs, including cell arrest, depletion and release. By adapting specific parameters, this model can be easily applied to abnormal conditions or other types of circulating cells for designing treatment protocols and guiding future experiments. PMID:26924777

  10. Psychology of computer use: IX. A menu of self-administered microcomputer-based neurotoxicology tests

    NASA Technical Reports Server (NTRS)

    Kennedy, R. S.; Baltzley, D. R.; Wilkes, R. L.; Kuntz, L. A.

    1989-01-01

    This study examined the feasibility of repeated self-administration of a newly developed battery of mental acuity tests which may have application in screening for fitness-for-duty or for persons who may be exposed to environmental stress, toxic agents, or disease. 16 subjects self-administered 18 microcomputer-based tests (13 new, 5 "core"), without proctors, over 10 sessions. The hardware performed well throughout the study and the tests appeared to be easily self-administered. Stabilities and reliabilities of the tests from the "core" battery were comparable to those obtained previously under more controlled experimental conditions. Eight of the new tests exceeded minimum criteria for metric and practical requirements and can be recommended as additions to the menu. Although the average retest reliability was high, cross-correlations between tests were low, implying factorial diversity. The menu can be used to form batteries with flexible total testing time which are likely to tap different mental processes and functions.

  11. Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats.

    PubMed

    Zhang, Li; Liu, Laura; Philip, Ann L; Martinez, Juan C; Guttierez, Juan C; Marella, Mathieu; Patki, Gaurav; Matsuno-Yagi, Akemi; Yagi, Takao; Thomas, Biju B

    2015-01-12

    Leber's hereditary optic neuropathy (LHON) is an inherited disorder affecting the retinal ganglion cells (RGCs) and their axons that lead to the loss of central vision. This study is aimed at evaluating the LHON symptoms in rats administered with rotenone microspheres into the superior colliculus (SC). Optical coherence tomography (OCT) analysis showed substantial loss of retinal nerve fiber layer (RNFL) thickness in rotenone injected rats. Optokinetic testing in rotenone treated rats showed decrease in head-tracking response. Electrophysiological mapping of the SC surface demonstrated attenuation of visually evoked responses; however, no changes were observed in the ERG data. The progressive pattern of disease manifestation in rotenone administered rats demonstrated several similarities with human disease symptoms. These rats with LHON-like symptoms can serve as a model for future investigators to design and implement reliable tests to assess the beneficial effects of therapeutic interventions for LHON disease.

  12. Regarding the inadvisability of administering postoperative analgesics in the drinking water of rats (Rattus norvegicus).

    PubMed

    Speth, R C; Smith, M S; Brogan, R S

    2001-11-01

    The feasibility of administering the pain reliever acetaminophen to rats via their water bottles was examined in this study. Two different preparations of acetaminophen were used, a cherry-flavored suspension and an alcohol-containing solution. Both preparations of acetaminophen were diluted to 6 mg/ml by using normal drinking water. When healthy unmanipulated rats were exposed to either of the acetaminophen preparations for the first time, the animals showed a dramatic reduction in fluid intake. A marked reduction in food intake also was associated with the cherry-flavored preparation. These reductions appear to be an expression of the well-characterized neophobic response that can be demonstrated by rodents when they encounter a novel taste. This neophobic behavior suggests that administering pain relievers to rats via their drinking water is counterproductive as a means of providing pain relief.

  13. Anatomical, physiological and experimental factors affecting the bioavailability of sc administered large biotherapeutics

    PubMed Central

    Fathallah, Anas M.; Balu-Iyer, Sathy V.

    2014-01-01

    Subcutaneous route of administration is highly desirable for protein therapeutics. It improves patient compliance and quality of life1,2, while reducing healthcare cost2. Recent evidence also suggests that sc administration of protein therapeutics can increase tolerability to some treatments such as intravenous immunoglobulin therapy (IVIG) by administering it subcutaneously (subcutaneous immunoglobulin therapy SCIG), which will reduce fluctuation in plasma drug concentration3. Furthermore, sc administration may reduce the risk of systemic infections associated with iv infusion1,2. This route, however, has its challenges especially for large multi-domain proteins. Poor bioavailability and poor scalability from preclinical models are often cited. This commentary will discuss barriers to sc absorption as well as physiological and experimental factors that could affect pharmacokinetics of subcutaneously administered large protein therapeutics in preclinical models. A mechanistic pharmacokinetic model is proposed as a potential tool to address the issue of scalability of sc pharmacokinetic from preclinical models to humans PMID:25411114

  14. 6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits.

    PubMed

    Ferri, S; Reina, R A; Braga, P

    1977-12-19

    The narcotic antagonist naloxone does not antagonize antinociception elicited in the rabbit by 100 microgram/kg of mescaline centrally administered, whereas pretreatment with 6-hydroxydopamine (6-OHDA) inhibits this mescaline effect. Stereotyped behavior of rabbits following central mescaline administration is also prevented by 6-hda pretreatment. Since 6-OHDA in known to produce a degeneration of catecholamine containing nerve terminals, a crucial role of catecholamines is suggested in the complex of effects seen in the rabbit after central administration of the hallucinogen.

  15. Justification of administered dose level in brain perfusion imaging with 99mTc-HMPAO

    NASA Astrophysics Data System (ADS)

    Stefanoyiannis, A. P.; Gerogiannis, I.; Geronikola-Trapali, X.; Armeniakos, I.; Prentakis, A.; Soultanis, S.; Chatziioannou, S. N.

    2011-09-01

    Brain perfusion imaging by means of 99mTc-HMPAO is widely used in the diagnosis of Alzheimer's disease. The administered dose range recommended by the manufacturer and reported in bibliography is rather wide (~ 9.5 - 27 mCi), necessitating further quantitative analysis. In the framework of this study, a quantitative evaluation of the radiopharmaceutical performance for different values of administered dose was carried out, based on image quality indicators. Evaluation of image quality was based on wavelet-generated contrast, noise, and contrast-to-noise ratio indicators, denoted as CI, NI and CNR respectively. Subsequently, a generic image quality index was correlated with the administered dose, to produce an overall performance indicator (denoted as PI). Application of appropriate statistical tests (analysis of variance for normal and Kruskal-Wallis test for non-normal distributions) showed that there is a statistically significant difference in CI (p < 0.01), NI (p < 0.001) and CNR (p < 0.05), but not in PI (p > 0.05) values. Application of Tukey test for CI and NI normal distributions demonstrated that CI (10 mCi) = CI (20 mCi) < CI (15 mCi) and NI (10 mCi) > NI (20 mCi), while NI (15 mCi) could not be characterised. Finally, application of non-parametric multiple comparisons showed that CNR (20 mCi) < CNR (10 mCi), while CNR (15 mCi) could not be characterised. Consequently, brain perfusion imaging, by means of 99mTc-HMPAO utilising an administered dose of 20 mCi, results in improved image quality on the basis of the estimated indicators. Additionally, this image quality improvement is sufficient to justify the increased patient radiation burden.

  16. The safety of self-administered allergen immunotherapy during the buildup and maintenance phases

    PubMed Central

    Schaffer, Frederick M.; Naples, Andrew R.; Ebeling, Myla; Hulsey, Thomas C.; Garner, Larry M.

    2015-01-01

    Background Self-administered allergen immunotherapy is considered controversial. We believe the implementation of a self-administration protocol characterized by patient preselection and a slow buildup phase is safe. Methods We analyzed 23,614 patient records and associated immunotherapy injections for systemic reactions (SR) during a 1-year period (2011 to 2012). SRs were graded in accordance with the World Allergy Organization (WAO) criteria. Results Thirty-seven SRs were reported for 23,614 patients who self-administered 2,021,600 injections yielding an annual SR rate of 0.16% (per patient) or 0.002% (per injection). Only 9 of 4643 pediatric (0.19%) and 28 of 18,971 adult patients (0.15%) experienced 1 or more SRs. No deaths (grade V SR) occurred. From 2009 through early 2014, over 90,000 patients received more than 10 million injections in accordance with the United Allergy Services (UAS) protocol without fatalities. Conclusion We believe this safety profile is due to a preselection of patients to exclude those with a high risk for adverse reactions and a slow immunotherapy buildup phase. In contrast, previous studies documented office-based SRs ranging from approximately 3% to greater than 14%. Thus, the UAS home-immunotherapy SR rate is significantly lower than office-based immunotherapy SR rates (p < 0.0001). The enhanced safety of this protocol results in a decreased frequency and severity of SRs. This safety report, derived from analyses of one of the largest patient cohorts studied, corroborates and expands the observations of previous studies of self-administered subcutaneous immunotherapy in a low-risk patient population by assessing self-administered allergen immunotherapy during the buildup and maintenance phases. PMID:25476041

  17. Pain in adolescent girls receiving human papillomavirus vaccine with concomitantly administered vaccines.

    PubMed

    Walter, Emmanuel B; Kemper, Alex R; Dolor, Rowena J; Dunne, Eileen F

    2015-02-01

    Using the Faces Pain Scale - Revised, we assessed injection site pain 10 minutes after vaccination in young females randomized to receive either quadrivalent human papillomavirus vaccine (HPV4) before or after concomitantly administered vaccines. Although pain was modestly more after HPV4 injection than after other vaccines, the pain intensity after HPV4 injection was significantly less in those who received HPV4 before receiving other concomitant vaccines.

  18. Difference in nephrotoxicity of vancomycin administered once daily and twice daily in rats.

    PubMed

    Konishi, Hiroki; Morita, Yukiko; Mizumura, Miyo; Iga, Ikumi; Nagai, Katsuhito

    2013-10-01

    We compared the degree of nephrotoxicity of vancomycin (VCM) administered once daily and twice daily in rats. VCM was intraperitoneally administered once daily to rats at a dose of 400 mg/kg (VCM-1-treated) or administered at a dose of 200 mg/kg twice daily at 12-hour intervals (VCM-2-treated) for 7 consecutive days. Creatinine clearance was decreased more markedly in VCM-1 rats relative to VCM-2 rats, although there was no significant difference in renal accumulation of VCM between the two groups. Renal superoxide dismutase activity was lower in VCM-1 rats than that in VCM-2 rats. The magnitude of histological change in kidney tissue was in agreement with the degree of alterations in the abovementioned biochemical values. These results suggest that the nephrotoxic effect of once-daily VCM administration is more pronounced than that of the twice-daily treatment. Our findings provide fundamental evidence for the advantage in choosing a divided VCM administration to attenuate nephrotoxicity.

  19. Induction of systemic immune responses to measles virus synthetic peptides administered intranasally.

    PubMed

    Hathaway, L J; Partidos, C D; Vohra, P; Steward, M W

    1995-11-01

    A systemic antibody response was induced when a chimeric peptide containing two copies of a promiscuous T-cell epitope and one copy of a B-cell epitope (TTB) from the fusion protein of measles virus (MV) was administered to mice intranasally without adjuvant. A higher antibody titre was produced when the peptide was administered intranasally with cholera toxin B subunit (CTB) as an adjuvant and these antibodies crossreacted with the MV. Furthermore, splenocytes from intranasally immunized mice proliferated in vitro in the presence of the TTB peptide. The immune response following intranasal immunization with the peptide was influenced by the MHC haplotype of the strain of mice used. Thus CBA and BALB/c mice were high responders whereas C57BL/6 mice were low responders. Although peptide administered intranasally with CTB to CBA mice induced an immune response, no significant protection was observed against intra-cranial challenge with canine distemper virus which is antigenically related to MV. PMID:8578832

  20. The Relative Reinforcing Strength of Methamphetamine and d-Amphetamine in Monkeys Self-Administering Cocaine

    PubMed Central

    Lile, Joshua A.; Charnigo, Richard J.; Nader, Michael A.

    2013-01-01

    Epidemiological data indicate that rates of methamphetamine misuse surpass those of d-amphetamine, but self-administration research in animals and humans has not typically demonstrated differences in their reinforcing effects. The present study used a within-session, exponentially-increasing progressive-ratio schedule and extended-access conditions to assess the relative reinforcing strength of d-amphetamine and methamphetamine in rhesus monkeys (n=5) trained to self-administer cocaine. A range of doses of methamphetamine (0.003–0.1 mg/kg/injection), d-amphetamine (0.003–0.1 mg/kg/injection) and cocaine (0.003–0.3 mg/kg/injection) was tested to capture the ascending and descending limbs of the dose-effect functions. Each drug functioned as a reinforcer, but the peak number of self-administered d-amphetamine injections was significantly lower compared to methamphetamine and cocaine; the peak number of self-administered injections of cocaine and methamphetamine did not differ. Although differences in availability and other social factors likely impact relative rates of abuse, the present data suggest that the greater reinforcing strength of methamphetamine contributes to its increased use compared to d-amphetamine. PMID:23907377