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Sample records for administered tests specification

  1. Comparison and Equating of Paper-Administered, Computer-Administered and Computerized Adaptive Tests of Achievement.

    ERIC Educational Resources Information Center

    Olsen, James B.; And Others

    Student achievement test scores were compared and equated, using three different testing methods: paper-administered, computer-administered, and computerized adaptive testing. The tests were developed from third and sixth grade mathematics item banks of the California Assessment Program. The paper and the computer-administered tests were identical…

  2. Systemically Administered, Target Organ-Specific Therapies for Regenerative Medicine

    PubMed Central

    Järvinen, Tero A. H.; May, Ulrike; Prince, Stuart

    2015-01-01

    Growth factors and other agents that could potentially enhance tissue regeneration have been identified, but their therapeutic value in clinical medicine has been limited for reasons such as difficulty to maintain bioactivity of locally applied therapeutics in the protease-rich environment of regenerating tissues. Although human diseases are treated with systemically administered drugs in general, all current efforts aimed at enhancing tissue repair with biological drugs have been based on their local application. The systemic administration of growth factors has been ruled out due to concerns about their safety. These concerns are warranted. In addition, only a small proportion of systemically administered drugs reach their intended target. Selective delivery of the drug to the target tissue and use of functional protein domains capable of penetrating cells and tissues could alleviate these problems in certain circumstances. We will present in this review a novel approach utilizing unique molecular fingerprints (“Zip/postal codes”) in the vasculature of regenerating tissues that allows target organ-specific delivery of systemically administered therapeutic molecules by affinity-based physical targeting (using peptides or antibodies as an “address tag”) to injured tissues undergoing repair. The desired outcome of targeted therapies is increased local accumulation and lower systemic concentration of the therapeutic payload. We believe that the physical targeting of systemically administered therapeutic molecules could be rapidly adapted in the field of regenerative medicine. PMID:26437400

  3. Baseline Geography Competency Test Administered in Indiana Universities.

    ERIC Educational Resources Information Center

    Bein, Frederick L.

    A baseline geography skills test was administered during 1987 to over 3,000 students who were enrolled in freshmen geography courses at 18 Indiana universities. Known as the National Council for Geographic Education Competency-Based Geography Test, Secondary Level, Form D, this test was used to measure the students' level of geographic ability in:…

  4. Test-retest reliability of psychological and neurobehavioral tests self-administered by computer.

    PubMed

    Campbell, K A; Rohlman, D S; Storzbach, D; Binder, L M; Anger, W K; Kovera, C A; Davis, K L; Grossmann, S J

    1999-03-01

    A series of 12 psychological and 7 neurobehavioral performance tests were administered twice to a nonclinical normative sample with 1 week between administrations. The tests were presented in a self-administered computerized format. One week test-retest reliabilities were comparable to conventional administration formats. The results suggest that individual test reliability is not affected when tests are administered as part of an extensive multi-measure battery. Computer administered test reliability coefficients also were compared to a Mixed Format (computer-conventional) administration with mixed format reliabilities generally similar to the reliabilities of published conventional tests but also generally lower than same format testing. Compared to psychological test reliability, neurobehavioral test reliability appeared more vulnerable to decreases with mixed format testing. These conclusions should not be generalized to all computer implemented tests as the qualities of the test implementation will affect the outcome. PMID:9971880

  5. Test-Retest Reliability of Psychological and Neurobehavioral Tests Self-Administered by Computer.

    ERIC Educational Resources Information Center

    Campbell, Keith A.; Rohlman, Diane S.; Storzbach, Daniel; Binder, Laurence M.; Anger, W. Kent; Kovera, Craig A.; Davis, Kelly L.; Grossman, Sandra J.

    1999-01-01

    Administered 12 psychological and 7 neurobehavioral performance tests twice to nonclinical normative samples of 30 adults (computer format only) and 30 adults (computer and conventional administration) with one week between administrations. Results suggest that individual test-retest reliability is not affected when tests are administered as part…

  6. Urine specific gravity test

    MedlinePlus

    Urine specific gravity is a laboratory test that shows the concentration of all chemical particles in the urine. ... changes to will tell the provider the specific gravity of your urine. The dipstick test gives only ...

  7. Urine specific gravity test

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/003587.htm Urine specific gravity test To use the sharing features on this page, please enable JavaScript. Urine specific gravity is a laboratory test that shows the concentration ...

  8. Rationale and Specifications for a Prototype, Group-Administered End-of-Unit Assessment Instrument for the SWRL Reading Program.

    ERIC Educational Resources Information Center

    Okada, Masahito; Besel, Ronald

    This document describes the purposes, rationale, and specifications of a prototype group-administered criterion exercise to be used with blocks 1-8 of the Southwest Regional Laboratory (SWRL) Reading Program. A description of the sampling domains, sampling procedures, and the methods employed in the construction of test items is presented. Also…

  9. Estimating the Impacts of Educational Interventions Using State Tests or Study-Administered Tests. NCEE 2012-4016

    ERIC Educational Resources Information Center

    Olsen, Robert B.; Unlu, Fatih; Price, Cristofer; Jaciw, Andrew P.

    2011-01-01

    This report examines the differences in impact estimates and standard errors that arise when these are derived using state achievement tests only (as pre-tests and post-tests), study-administered tests only, or some combination of state- and study-administered tests. State tests may yield different evaluation results relative to a test that is…

  10. Development of Teacher-Administered Tests for the SWRL Reading Programs.

    ERIC Educational Resources Information Center

    Niedermeyer, Fred C.; Sullivan, Howard J.

    To investigate the type of classroom testing format most appropriate for the Southwest Regional Laboratory (SWRL) Mod 2 Reading Program, three types of teacher-administered tests for the SWRL Second-Year Communication Skills Program were developed and tried out during the 1970-71 school year. The tests were administered by the classroom teacher as…

  11. Cylinder Test Specification

    SciTech Connect

    Richard Catanach; Larry Hill; Herbert Harry; Ernest Aragon; Don Murk

    1999-10-01

    The purpose of the cylinder testis two-fold: (1) to characterize the metal-pushing ability of an explosive relative to that of other explosives as evaluated by the E{sub 19} cylinder energy and the G{sub 19} Gurney energy and (2) to help establish the explosive product equation-of-state (historically, the Jones-Wilkins-Lee (JWL) equation). This specification details the material requirements and procedures necessary to assemble and fire a typical Los Alamos National Laboratory (LANL) cylinder test. Strict adherence to the cylinder. material properties, machining tolerances, material heat-treatment and etching processes, and high explosive machining tolerances is essential for test-to-test consistency and to maximize radial wall expansions. Assembly and setup of the cylinder test require precise attention to detail, especially when placing intricate pin wires on the cylinder wall. The cylinder test is typically fired outdoors and at ambient temperature.

  12. [Technical specifications for rational clinical use of parenterally administered Chinese medicine (draft version for comments)].

    PubMed

    Xie, Yan-Ming; Li, Ming-Quan; Zhang, Yun-Ling; Ma, Rong; Xian, Shao-Xiang; Liu, Jian; Li, Su-Yun; Zhao, Yu-Bin

    2013-09-01

    The regulations on basic clinical use of parenterally administered Chinese medicine, issued jointly in 2008, by the ministry of health (MOH), China food and drug administration (SFDA) and the state administration of traditional Chinese medicine (SATCM). Integrating actual clinical practice, these presented doctors and nurses with detailed specifications for the safe use of parenterally administered Chinese medicine. The regulations emphasize the use of Chinese medicine pattern differentiation, use in strict accordance with instructions, and they prohibit use combined with other medicines. The emphasis of the regulations are practicality and operability, and provide meaningful guidance to doctors and nurses for the rational and safe use of parenterally administered Chinese medicine, to reduce adverse reactions/adverse events caused by improper use. PMID:24471306

  13. 30 CFR 250.1508 - What must I do when MMS administers written or oral tests?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What must I do when MMS administers written or oral tests? 250.1508 Section 250.1508 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... authorized representative to administer written or oral tests; and (b) Identify personnel by current...

  14. Using Technology to Create and Administer Accessible Tests

    ERIC Educational Resources Information Center

    Salend, Spencer

    2009-01-01

    Technology is transforming many aspects of society including the ways teachers teach and students learn. Although technology has been firmly established as a teaching tool across a range of content areas, educators are realizing that technology also offers innovative ways to help their students take standardized tests that comply with the mandates…

  15. 30 CFR 250.1508 - What must I do when BSEE administers written or oral tests?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Control and Production Safety Training § 250.1508 What must I do when BSEE administers written or oral... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What must I do when BSEE administers written or oral tests? 250.1508 Section 250.1508 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL...

  16. 30 CFR 250.1508 - What must I do when BSEE administers written or oral tests?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Control and Production Safety Training § 250.1508 What must I do when BSEE administers written or oral... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What must I do when BSEE administers written or oral tests? 250.1508 Section 250.1508 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL...

  17. 30 CFR 250.1508 - What must I do when BSEE administers written or oral tests?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Control and Production Safety Training § 250.1508 What must I do when BSEE administers written or oral... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What must I do when BSEE administers written or oral tests? 250.1508 Section 250.1508 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL...

  18. Effects of microcomputer-administered diagnostic testing on immediate and continuing science achievement and attitudes

    NASA Astrophysics Data System (ADS)

    Waugh, Michael Leonard

    This investigation had three purposes: (1) to document any immediate and continuing benefits associated with the use of microcomputer-administered testing; (2) to determine what type of student might benefit most from microcomputer-administered diagnostic testing; and (3) to document the feasibility of microcomputer-administered diagnostic testing. The subjects of the study were enrolled in a biology course based on the BSCS Blue text. A random half of the students received behaviorally-stated performance objectives, while the remaining half received behaviorally-stated performance objectives in conjunction with microcomputer-administered diagnostic testing. The results of this study indicate that microcomputer-administered diagnostic testing can positively influence the immediate, but not the continuing, achievement of students in science. In addition, neither student aptitude nor achievement motivation level were found to interact with treatment or influence achievement. Affective data indicate that students react favorably to the use of objectives, computers, and diagnostic testing. Cost summary data reveal that when the expense of administering diagnostic testing by microcomputer is prorated over a five-year period, the cost of a diagnostic test is reduced to approximately three cents.

  19. Reliability Analysis for the Internationally Administered 2002 Series GED Tests. GED Testing Service[R] Research Studies, 2009-3

    ERIC Educational Resources Information Center

    Setzer, J. Carl; He, Yi

    2009-01-01

    Reliability Analysis for the Internationally Administered 2002 Series GED (General Educational Development) Tests Reliability refers to the consistency, or stability, of test scores when the authors administer the measurement procedure repeatedly to groups of examinees (American Educational Research Association [AERA], American Psychological…

  20. Walk a Mile in My Shoes: Stakeholder Accounts of Testing Experience with a Computer-Administered Test

    ERIC Educational Resources Information Center

    Fox, Janna; Cheng, Liying

    2015-01-01

    In keeping with the trend to elicit multiple stakeholder responses to operational tests as part of test validation, this exploratory mixed methods study examines test-taker accounts of an Internet-based (i.e., computer-administered) test in the high-stakes context of proficiency testing for university admission. In 2013, as language testing…

  1. Should Creativity Tests Be Administered under Testlike Conditions? An Empirical Study of Three Alternative Conditions.

    ERIC Educational Resources Information Center

    Hattie, John

    1980-01-01

    Three conditions for administering creativity tests by Torrance and by Wallach and Kogan were compared: (1) untimed, gamelike; (2) conventional testlike; and (3) administration of measures under testlike conditions on two adjacent days, using the second testing as the predictor. The conventional testlike condition seems optimal. (Author/CP)

  2. Psychology of computer use: IX. A menu of self-administered microcomputer-based neurotoxicology tests

    NASA Technical Reports Server (NTRS)

    Kennedy, R. S.; Baltzley, D. R.; Wilkes, R. L.; Kuntz, L. A.

    1989-01-01

    This study examined the feasibility of repeated self-administration of a newly developed battery of mental acuity tests which may have application in screening for fitness-for-duty or for persons who may be exposed to environmental stress, toxic agents, or disease. 16 subjects self-administered 18 microcomputer-based tests (13 new, 5 "core"), without proctors, over 10 sessions. The hardware performed well throughout the study and the tests appeared to be easily self-administered. Stabilities and reliabilities of the tests from the "core" battery were comparable to those obtained previously under more controlled experimental conditions. Eight of the new tests exceeded minimum criteria for metric and practical requirements and can be recommended as additions to the menu. Although the average retest reliability was high, cross-correlations between tests were low, implying factorial diversity. The menu can be used to form batteries with flexible total testing time which are likely to tap different mental processes and functions.

  3. Specification of pyro shock tests

    NASA Technical Reports Server (NTRS)

    Trummel, M.

    1976-01-01

    Specifications of pyro shock tests are treated as the interconnection between raw measurements (or estimates) of the environment and the various test methods available. After a definition of the environment, various aspects of test method specification are discussed including one-sided pulses, test simulation parameters, and the effects of Q. Different test configurations are considered including rigid fixture tests, pseudo-real structure, and real structure.

  4. Specific construction tests

    NASA Technical Reports Server (NTRS)

    Mcrae, W. V., Jr.

    1980-01-01

    The technical feasibility of the Satellite Power System (SPS) is discussed. The development of feasible operational concepts and conceptualization of specific construction tasks are examined. The logic flow of functional analyses of both the rectenna and the satellite is illustrated. Constraints placed upon the construction processes and equipment by the satellite design are outlined. The construction tasks, when defined and combined into an integrated schedule establish, a time line for construction mass flow demands to be satisfied by the space transportation systems. An example of satellite constructive demands and HLLV delivery capabilities is given.

  5. 34 CFR 462.41 - How must tests be administered in order to accurately measure educational gain?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assessment policy; (3)(i) Administer post-tests with a secure, parallel, equated form of the same test—either traditional paper and pencil or computer-administered instruments—for which forms are constructed prior...

  6. A menu of self-administered microcomputer-based neurotoxicology tests

    NASA Technical Reports Server (NTRS)

    Kennedy, Robert S.; Wilkes, Robert L.; Kuntz, Lois-Ann; Baltzley, Dennis R.

    1988-01-01

    This study examined the feasibility of repeated self-administration of a newly developed battery of mental acuity tests. Researchers developed this battery to be used to screen the fitness for duty of persons in at-risk occupations (astronauts, race car drivers), or those who may be exposed to environmental stress, toxic agents, or disease. The menu under study contained cognitive and motor tests implemented on a portable microcomputer including: a five-test core battery, lasting six minutes, which had demonstrable reliabilities and stability from several previous repeated-measures studies, and also 13 new tests, lasting 42 minutes, which had appeared in other batteries but had not yet been evaluated for repeated-measures implementation in this medium. Sixteen subjects self-administered the battery over 10 repeated sessions. The hardware performed well throughout the study and the tests appeared to be easily self-administered. Stabilities and reliabilities of the test from the core battery were comparable to those obtained previously under more controlled experimental conditions. Analyses of metric properties of the remaining 13 tests produced eight additional tests with satisfactory properties. Although the average retest reliability was high, cross-correlations between tests were low, indicating factorial richness. The menu can be used to form batteries of flexible total testing time which are likely to tap different mental processes and functions.

  7. Automotive Lubricant Specification and Testing

    NASA Astrophysics Data System (ADS)

    Fox, M. F.

    This chapter concerns commercial lubricant specification and testing, drawing together the many themes of previous chapters. Military lubricant standards were a very strong initial influence during World War II and led to the separate historical development of the North American and European specification systems. The wide range of functions that a successful lubricant must satisfy is discussed, together with issues of balancing special or universal applications, single or multiple engine tests, the philosophy of accelerated testing and the question of 'who sets the standards?' The role of engine tests and testing organisations is examined.

  8. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1998-03-20

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AX-B Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation.

  9. Specific test and evaluation plan

    SciTech Connect

    Hays, W.H.

    1997-12-09

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a ``lower tier`` document based on the W-314 Test and Evaluation Plan (TEP) This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the modifications of the AN-A valve pit. The Project Design Specifications (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the modifications to the 241-AN-A Valve Pit. The STEP will be utilized in conjunction with the TEP for verification and validation.

  10. Effects of Informed Item Selection on Test Performance and Anxiety for Examinees Administered a Self-Adapted Test.

    ERIC Educational Resources Information Center

    Plake, Barbara S.; And Others

    In self-adapted testing (SAT), examinees select the difficulty level of items administered. This study investigated three variations of prior information provided when taking an SAT: (1) no information (examinees selected item difficulty levels without prior information); (2) view (examinees inspected a typical item from each difficulty level…

  11. Comparability of Computer- and Paper-Administered Multiple-Choice Tests for K-12 Populations: A Synthesis

    ERIC Educational Resources Information Center

    Kingston, Neal M.

    2009-01-01

    There have been many studies of the comparability of computer-administered and paper-administered tests. Not surprisingly (given the variety of measurement and statistical sampling issues that can affect any one study) the results of such studies have not always been consistent. Moreover, the quality of computer-based test administration systems…

  12. 49 CFR 40.347 - What functions may C/TPAs perform with respect to administering testing?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false What functions may C/TPAs perform with respect to administering testing? 40.347 Section 40.347 Transportation Office of the Secretary of Transportation PROCEDURES... Agents § 40.347 What functions may C/TPAs perform with respect to administering testing? As a...

  13. 49 CFR 40.347 - What functions may C/TPAs perform with respect to administering testing?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false What functions may C/TPAs perform with respect to administering testing? 40.347 Section 40.347 Transportation Office of the Secretary of Transportation PROCEDURES... Agents § 40.347 What functions may C/TPAs perform with respect to administering testing? As a...

  14. 49 CFR 40.347 - What functions may C/TPAs perform with respect to administering testing?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What functions may C/TPAs perform with respect to administering testing? 40.347 Section 40.347 Transportation Office of the Secretary of Transportation PROCEDURES... Agents § 40.347 What functions may C/TPAs perform with respect to administering testing? As a...

  15. 49 CFR 40.347 - What functions may C/TPAs perform with respect to administering testing?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false What functions may C/TPAs perform with respect to administering testing? 40.347 Section 40.347 Transportation Office of the Secretary of Transportation PROCEDURES... Agents § 40.347 What functions may C/TPAs perform with respect to administering testing? As a...

  16. 49 CFR 40.347 - What functions may C/TPAs perform with respect to administering testing?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false What functions may C/TPAs perform with respect to administering testing? 40.347 Section 40.347 Transportation Office of the Secretary of Transportation PROCEDURES... Agents § 40.347 What functions may C/TPAs perform with respect to administering testing? As a...

  17. Development of a self-administered web-based test for longitudinal cognitive assessment.

    PubMed

    Ruano, Luis; Sousa, Andreia; Severo, Milton; Alves, Ivânia; Colunas, Márcio; Barreto, Rui; Mateus, Cátia; Moreira, Sandra; Conde, Eduardo; Bento, Virgílio; Lunet, Nuno; Pais, Joana; Tedim Cruz, Vítor

    2016-01-01

    Sequential testing with brief cognitive tools has been recommended to improve cognitive screening and monitoring, however the few available tools still depend on an external evaluator and periodic visits. We developed a self-administered computerized test intended for longitudinal cognitive testing (Brain on Track). The test can be performed from a home computer and is composed of several subtests, expected to evaluate different cognitive domains, all including random elements to minimize learning effects. An initial (A) and a refined version of the test (B) were applied to patients with mild cognitive impairment or early dementia (n = 88) and age and education-matched controls. A subsample of a population-based cohort (n = 113) performed the test at home every three months to evaluate test-retest reliability. The test's final version Cronbach's alpha was 0.90, test scores were significantly different between patients and controls (p = 0.001), the area under the receiver operating characteristic curve was 0.75 and the smallest real difference (43.04) was lower than the clinical relevant difference (56.82). In the test-retest reliability analysis 9/10 subtests showed two-way mixed single intraclass consistency correlation coefficient >0.70. These results imply good internal consistency, discriminative ability and reliability when performed at home, encouraging further longitudinal clinical and population-based studies. PMID:26743329

  18. Development of a self-administered web-based test for longitudinal cognitive assessment

    PubMed Central

    Ruano, Luis; Sousa, Andreia; Severo, Milton; Alves, Ivânia; Colunas, Márcio; Barreto, Rui; Mateus, Cátia; Moreira, Sandra; Conde, Eduardo; Bento, Virgílio; Lunet, Nuno; Pais, Joana; Tedim Cruz, Vítor

    2016-01-01

    Sequential testing with brief cognitive tools has been recommended to improve cognitive screening and monitoring, however the few available tools still depend on an external evaluator and periodic visits. We developed a self-administered computerized test intended for longitudinal cognitive testing (Brain on Track). The test can be performed from a home computer and is composed of several subtests, expected to evaluate different cognitive domains, all including random elements to minimize learning effects. An initial (A) and a refined version of the test (B) were applied to patients with mild cognitive impairment or early dementia (n = 88) and age and education-matched controls. A subsample of a population-based cohort (n = 113) performed the test at home every three months to evaluate test-retest reliability. The test’s final version Cronbach’s alpha was 0.90, test scores were significantly different between patients and controls (p = 0.001), the area under the receiver operating characteristic curve was 0.75 and the smallest real difference (43.04) was lower than the clinical relevant difference (56.82). In the test-retest reliability analysis 9/10 subtests showed two-way mixed single intraclass consistency correlation coefficient >0.70. These results imply good internal consistency, discriminative ability and reliability when performed at home, encouraging further longitudinal clinical and population-based studies. PMID:26743329

  19. Screening for Substance Use Disorder among Incarcerated Men with the Alcohol, Smoking, Substance Involvement Screening Test (ASSIST): A Comparative Analysis of Computer-administered and Interviewer-administered Modalities

    PubMed Central

    Wolff, Nancy; Shi, Jing

    2015-01-01

    Substance use disorders are overrepresented in incarcerated male populations. Cost- effective screening for alcohol and substance use problems among incarcerated populations is a necessary first step forward intervention. The Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) holds promise because it has strong psychometric properties, requires minimal training, is easy to score, is available in the public domain but, because of complicated skip patterns, cannot be self-administered. This study tests the feasibility, reliability, and validity of using computer-administered self-interviewing (CASI) versus interviewer-administered interviewing (IAI) to screen for substance use problems among incarcerated men using the ASSIST. A 2 X 2 factorial design was used to randomly assign 396 incarcerated men to screening modality. Findings indicate that computer screening was feasible. Compared to IAI, CASI produced equally reliable screening information on substance use and symptom severity, with test-retest intraclass correlations for ASSIST total and substance-specific scores ranging from 0.7 to 0.9, and ASSIST substance-specific scores and a substance abuse disorder diagnosis based on the Structured Clinical Interview (SCID) were significantly correlated for IAI and CASI. These findings indicate that data on substance use and symptom severity using the ASSIST can be reliably and validly obtained from CASI technology, increasing the efficiency by which incarcerated populations can be screened for substance use problems and, those at risk, identified for treatment. PMID:25659203

  20. Screening for Substance Use Disorder Among Incarcerated Men with the Alcohol, Smoking, Substance Involvement Screening Test (ASSIST): A Comparative Analysis of Computer-Administered and Interviewer-Administered Modalities.

    PubMed

    Wolff, Nancy; Shi, Jing

    2015-06-01

    Substance use disorders are overrepresented in incarcerated male populations. Cost-effective screening for alcohol and substance use problems among incarcerated populations is a necessary first step forward intervention. The Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) holds promise because it has strong psychometric properties, requires minimal training, is easy to score, is available in the public domain but, because of complicated skip patterns, cannot be self-administered. This study tests the feasibility, reliability, and validity of using computer-administered self-interviewing (CASI) versus interviewer-administered interviewing (IAI) to screen for substance use problems among incarcerated men using the ASSIST. A 2×2 factorial design was used to randomly assign 396 incarcerated men to screening modality. Findings indicate that computer screening was feasible. Compared to IAI, CASI produced equally reliable screening information on substance use and symptom severity, with test-retest intraclass correlations for ASSIST total and substance-specific scores ranging from 0.7 to 0.9, and ASSIST substance-specific scores and a substance abuse disorder diagnosis based on the Structured Clinical Interview (SCID) were significantly correlated for IAI and CASI. These findings indicate that data on substance use and symptom severity using the ASSIST can be reliably and validly obtained from CASI technology, increasing the efficiency by which incarcerated populations can be screened for substance use problems and, those at risk, identified for treatment. PMID:25659203

  1. Specification-Based Testing Via Domain Specific Language

    NASA Astrophysics Data System (ADS)

    Sroka, Michal; Nagy, Roman; Fisch, Dominik

    2014-12-01

    The article presents tCF (testCaseFramework) - a domain specific language with corresponding toolchain for specification-based software testing of embedded software. tCF is designed for efficient preparation of maintainable and intelligible test cases and for testing process automation, as it allows to generate platform specific test cases for various testing levels. The article describes the essential parts of the tCF meta-model and the applied concept of platform specific test cases generators.

  2. Comparing Two Conditions of Administering the Six-Minute Walk Test in People with Multiple Sclerosis

    PubMed Central

    Sandroff, Brian M.; Pilutti, Lara A.; Dlugonski, Deirdre; Learmonth, Yvonne C.; Pula, John H.

    2014-01-01

    Objective: This quasi-experimental study was conducted to determine whether differences existed in the total distance walked and energy expended between two conditions of administering the 6-Minute Walk test (6MW) across different levels of disability in people with multiple sclerosis (MS). Methods: The sample comprised 160 individuals with MS. One group of participants (n = 82) completed a 6MW while wearing a portable metabolic unit (K4b2, Cosmed, Italy) in a square hallway with four corridors and performing 90° turns. Another group (n = 78) completed a 6MW while wearing the same metabolic unit in a single corridor and performing 180° turns. Main outcome measures included total distance walked (in feet) and oxygen consumption (in milliliters per minute) expressed as 30-second averages for 1 minute before the 6MW and over the entire 6MW. Disability status was assessed using the Patient-Determined Disease Steps scale. Results: Participants undertaking the 6MW in a single corridor (1412 ft) walked 37 ft (2.7%) farther than those undertaking the test in a square hallway (1375 ft), but this difference was not statistically significant (F = 0.45, P = .51). Those completing the 6MW in a single corridor expended more energy than those completing the 6MW in the square hallway with four corridors (F = 3.41, P < .01). Conclusions: Either protocol is acceptable, but researchers should be aware of the additional physiological demands when administering the 6MW in a single corridor with 180° turns. PMID:24688354

  3. Investigating Administered Essay and Multiple-Choice Tests in the English Department of Islamic Azad University, Hamedan Branch

    ERIC Educational Resources Information Center

    Karimi, Lotfollah; Mehrdad, Ali Gholami

    2012-01-01

    This study has attempted to investigate the administered written tests in the language department of Islamic Azad University of Hamedan, Iran from validity, practicality and reliability points of view. To this end two steps were taken. First, examining 112 tests, we knew that the face validity of 50 tests had been threatened, 9 tests lacked…

  4. Targeting synaptic dysfunction in Alzheimer's disease by administering a specific nutrient combination.

    PubMed

    van Wijk, Nick; Broersen, Laus M; de Wilde, Martijn C; Hageman, Robert J J; Groenendijk, Martine; Sijben, John W C; Kamphuis, Patrick J G H

    2014-01-01

    Synapse loss and synaptic dysfunction are pathological processes already involved in the early stages of Alzheimer's disease (AD). Synapses consist principally of neuronal membranes, and the neuronal and synaptic losses observed in AD have been linked to the degeneration and altered composition and structure of these membranes. Consequently, synapse loss and membrane-related pathology provide viable targets for intervention in AD. The specific nutrient combination Fortasyn Connect (FC) is designed to ameliorate synapse loss and synaptic dysfunction in AD by addressing distinct nutritional needs believed to be present in these patients. This nutrient combination comprises uridine, docosahexaenoic acid, eicosapentaenoic acid, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium, and is present in Souvenaid, a medical food intended for use in early AD. It has been hypothesized that FC counteracts synaptic loss and reduces membrane-related pathology in AD by providing nutritional precursors and cofactors that act together to support neuronal membrane formation and function. Preclinical studies formed the basis of this hypothesis which is being validated in a broad clinical study program investigating the potential of this nutrient combination in AD. Memory dysfunction is one key early manifestation in AD and is associated with synapse loss. The clinical studies to date show that the FC-containing medical food improves memory function and preserves functional brain network organization in mild AD compared with controls, supporting the hypothesis that this intervention counteracts synaptic dysfunction. This review provides a comprehensive overview of basic scientific studies that led to the creation of FC and of its effects in various preclinical models. PMID:23985420

  5. 21 CFR 660.26 - Specificity tests and avidity tests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Specificity tests and avidity tests. 660.26... (CONTINUED) BIOLOGICS ADDITIONAL STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Blood Grouping Reagent § 660.26 Specificity tests and avidity tests. Specificity and avidity tests shall be...

  6. 21 CFR 660.26 - Specificity tests and avidity tests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Specificity tests and avidity tests. 660.26 Section...) BIOLOGICS ADDITIONAL STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Blood Grouping Reagent § 660.26 Specificity tests and avidity tests. Specificity and avidity tests shall be performed using...

  7. Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice

    SciTech Connect

    Morishita, Yuki; Yoshioka, Yasuo; Satoh, Hiroyoshi; Nojiri, Nao; Nagano, Kazuya; Abe, Yasuhiro; Nabeshi, Hiromi; Yoshikawa, Tomoaki; Tsutsumi, Yasuo

    2012-04-06

    Highlights: Black-Right-Pointing-Pointer There is rising concern regarding the potential health risks of nanomaterials. Black-Right-Pointing-Pointer Few studies have investigated the effect of nanomaterials on the reproductive system. Black-Right-Pointing-Pointer Here, we evaluated the intra-testicular distribution of nanosilica particles. Black-Right-Pointing-Pointer We showed that nanosilica particles can penetrate the blood-testis barrier. Black-Right-Pointing-Pointer These data provide basic information on ways to create safer nanomaterials. -- Abstract: Amorphous nanosilica particles (nSP) are being utilized in an increasing number of applications such as medicine, cosmetics, and foods. The reduction of the particle size to the nanoscale not only provides benefits to diverse scientific fields but also poses potential risks. Several reports have described the in vivo and in vitro toxicity of nSP, but few studies have examined their effects on the male reproductive system. The aim of this study was to evaluate the testicular distribution and histologic effects of systemically administered nSP. Mice were injected intravenously with nSP with diameters of 70 nm (nSP70) or conventional microsilica particles with diameters of 300 nm (nSP300) on two consecutive days. The intratesticular distribution of these particles 24 h after the second injection was analyzed by transmission electron microscopy. nSP70 were detected within sertoli cells and spermatocytes, including in the nuclei of spermatocytes. No nSP300 were observed in the testis. Next, mice were injected intravenously with 0.4 or 0.8 mg nSP70 every other day for a total of four administrations. Testes were harvested 48 h and 1 week after the last injection and stained with hematoxylin-eosin for histologic analysis. Histologic findings in the testes of nSP70-treated mice did not differ from those of control mice. Taken together, our results suggest that nSP70 can penetrate the blood-testis barrier and the

  8. Measuring individuals' response quality in self-administered psychological tests: an introduction to Gendre's functional method

    PubMed Central

    Dupuis, Marc; Meier, Emanuele; Capel, Roland; Gendre, Francis

    2015-01-01

    The functional method is a new test theory using a new scoring method that assumes complexity in test structure, and thus takes into account every correlation between factors and items. The main specificity of the functional method is to model test scores by multiple regression instead of estimating them by using simplistic sums of points. In order to proceed, the functional method requires the creation of hyperspherical measurement space, in which item responses are expressed by their correlation with orthogonal factors. This method has three main qualities. First, measures are expressed in the absolute metric of correlations; therefore, items, scales and persons are expressed in the same measurement space using the same single metric. Second, factors are systematically orthogonal and without errors, which is optimal in order to predict other outcomes. Such predictions can be performed to estimate how one would answer to other tests, or even to model one's response strategy if it was perfectly coherent. Third, the functional method provides measures of individuals' response validity (i.e., control indices). Herein, we propose a standard procedure in order to identify whether test results are interpretable and to exclude invalid results caused by various response biases based on control indices. PMID:26136693

  9. 34 CFR 462.41 - How must tests be administered in order to accurately measure educational gain?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... measure educational gain? 462.41 Section 462.41 Education Regulations of the Offices of the Department of... to accurately measure educational gain? (a) General. A local eligible provider must measure the... provider must— (1) Administer a pre-test to measure a student's educational functioning level at intake,...

  10. 34 CFR 462.41 - How must tests be administered in order to accurately measure educational gain?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... measure educational gain? 462.41 Section 462.41 Education Regulations of the Offices of the Department of... to accurately measure educational gain? (a) General. A local eligible provider must measure the... provider must— (1) Administer a pre-test to measure a student's educational functioning level at intake,...

  11. 34 CFR 462.41 - How must tests be administered in order to accurately measure educational gain?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... measure educational gain? 462.41 Section 462.41 Education Regulations of the Offices of the Department of... to accurately measure educational gain? (a) General. A local eligible provider must measure the... provider must— (1) Administer a pre-test to measure a student's educational functioning level at intake,...

  12. 34 CFR 462.41 - How must tests be administered in order to accurately measure educational gain?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... measure educational gain? 462.41 Section 462.41 Education Regulations of the Offices of the Department of... to accurately measure educational gain? (a) General. A local eligible provider must measure the... provider must— (1) Administer a pre-test to measure a student's educational functioning level at intake,...

  13. Fifteen Year Follow-Up Geography Skills Test Administered in Indiana, 1987 and 2002

    ERIC Educational Resources Information Center

    Bein, F. L.; Hayes, James J.; Jones, Thomas G.

    2009-01-01

    After fifteen years of geographic education efforts, a baseline geography skills test was repeated in Indiana. In 2002, 2,278 students in college freshman geography courses were tested with a revision of the National Council for Geographic Education Competency-Based Geography Test, Secondary Level Form II. The test measured geographic ability in…

  14. 30 CFR 250.1509 - What must I do when MMS administers or requires hands-on, simulator, or other types of testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS... to administer or witness the testing; (b) Identify personnel by current position, years of...

  15. Prostate-specific antigen (PSA) blood test

    MedlinePlus

    Prostate-specific antigen; Prostate cancer screening test ... special steps are needed to prepare for this test. ... Reasons for a PSA test: This test may be done to screen for prostate cancer. It is also used to follow people after prostate cancer ...

  16. Specificity of a Maximal Step Exercise Test

    ERIC Educational Resources Information Center

    Darby, Lynn A.; Marsh, Jennifer L.; Shewokis, Patricia A.; Pohlman, Roberta L.

    2007-01-01

    To adhere to the principle of "exercise specificity" exercise testing should be completed using the same physical activity that is performed during exercise training. The present study was designed to assess whether aerobic step exercisers have a greater maximal oxygen consumption (max VO sub 2) when tested using an activity specific, maximal step…

  17. Development of a menu of performance tests self-administered on a portable microcomputer

    NASA Technical Reports Server (NTRS)

    Wilkes, Robert L.; Kuntz, Lois-Ann; Kennedy, Robert S.

    1987-01-01

    Eighteen cognitive, motor, and information processing performance subtests were screened for self-administration over 10 trials by 16 subjects. When altered presentation forms of the same test were collectively considered, the battery composition was reduced to 10 distinctly different measures. A fully automated microbased testing system was employed in presenting the battery of subtests. Successful self-administration of the battery provided for the field testing of the automated system and facilitated convenient data collection. Total test administration time was 47.2 minutes for each session. Results indicated that nine of the tests stabilized, but for a short battery of tests only five are recommended for use in repeated-measures research. The five recommended tests include: the Tapping series, Number Comparison, Short-term Memory, Grammatical Reasoning, and 4-Choice Reaction Time. These tests can be expected to reveal three factors: (1) cognition, (2) processing quickness, and (3) motor. All the tests stabilized in 24 minutes, or approximately two 12-minute sessions.

  18. Paradigmatic Results of a Word Association Test Administered in English and Farsi.

    ERIC Educational Resources Information Center

    Crable, Elaine Ann; Johnson, David

    A study was carried out to test the hypothesis that a difference exists between the results of a paradigmatic/syntagmatic word association test given in an individual's native language and in his second language. The sample used in this study consists of 23 Iranian officers attending a course at Air University in Alabama. Their primary language is…

  19. Choice in HIV testing: the acceptability and anticipated use of a self-administered at-home oral HIV test among South Africans.

    PubMed

    Kelvin, Elizabeth A; Cheruvillil, Sonia; Christian, Stephanie; Mantell, Joanne E; Milford, Cecilia; Rambally-Greener, Letitia; Mosery, Nzwakie; Greener, Ross; Smit, Jennifer A

    2016-07-01

    Combination HIV prevention is being widely promoted by funders. This strategy aims to offer HIV prevention choices that can be selected and combined to decrease HIV risk in ways that fit with each individual's situation. Treatment as prevention and pre-exposure prophylaxis are two new evidence-based strategies to decrease HIV incidence, both of which require high HIV testing rates to be effective, and the Joint United Nations Programme on HIV/AIDS (UNAIDS) has set a goal of 90% of HIV-positive individuals knowing their status by 2030. However, HIV testing rates in many countries remain suboptimal. Just as no single HIV prevention method is ideal for all people in all situations, no single HIV testing modality is likely to be acceptable to everyone. By offering HIV testing choices, we may be able to increase testing rates. However, many low-resourced countries have been slow to take up new HIV testing options such as the self-administered at-home oral HIV test that is currently available in the United States. In this paper, we present findings from 20 in-depth interviews, conducted in 2010, documenting opinions about self-administered at-home oral HIV testing, a testing modality still largely unavailable in Africa. Participants were clients of three primary healthcare clinics in South Africa. Self-testing was seen as enabling confidentiality/privacy, saving time, and facilitating testing together with partners. However, concerns were raised about psychological distress when testing at home without a counsellor. Some suggested this concern could be minimised by having experienced clinic-based HIV testing and counselling before getting self-testing kits for home use. Thus, self-administered HIV testing could be an option added to the current testing modalities to address some important barriers to testing. PMID:27399040

  20. Generation and Optimization of the Self-Administered Bleeding Assessment Tool (Self-BAT) and its Validation as a Screening Test for von Willebrand Disease

    PubMed Central

    Deforest, Meghan; Grabell, Julie; Albert, Shirren; Young, Jane; Tuttle, Angie; Hopman, Wilma M.; James, Paula D.

    2015-01-01

    Summary Introduction/Aim Our aim was to generate, optimize and validate a self-administered bleeding assessment tool (BAT) for von Willebrand disease (VWD). Methods In Phase 1, medical terminology in the expert-administered ISTH-BAT was converted to a grade 4 reading level to produce the first version of the Self-BAT which was then optimized to ensure agreement with the ISTH-BAT. In Phase 2, the normal range of bleeding scores was determined and test-retest reliability analyzed. In Phase 3, the optimized Self-BAT was tested as a screening tool for first time referrals to the Hematology clinic. Results BS from the final optimized version of the Self-BAT showed an excellent intra-class correlation coefficient (ICC) of 0.87 with ISTH-BAT BS in Phase 1. In Phase 2, the normal range of bleeding scores for the optimized Self-BAT was determined to be 0 to +5 for females and 0 to +3 for males and excellent test-retest reliability was shown (ICC = 0.95). In Phase 3, we showed that a positive Self-BAT BS (≥ 6 for females, ≥ 4 for males) has a sensitivity of 78%, specificity of 23%, positive predictive value (PPV) of 0.15 and negative predictive value (NPV) of 0.86 for VWD; these figures improved when just the females were analyzed; sensitivity of 100%, specificity of 21%, PPV=0.17 and NPV=1.0. Conclusion We show an optimized Self-BAT can generate comparable BS to the expert-administered ISTH-BAT and is a reliable, effective screening tool to incorporate into the assessment of individuals, particularly women, referred for a possible bleeding disorder. PMID:26179127

  1. A New Method for Administering and Scoring Multiple-Choice Tests: Theoretical Considerations and Empirical Results.

    ERIC Educational Resources Information Center

    Cross, Lawrence H.; And Others

    A new scoring procedure for multiple choice tests attempts to assess partial knowledge and to restrict guessing. It is a variant of Coombs' elimination scoring method, adapted for use with the carbon-shield answer sheets commonly used with answer-until-correct scoring. Examinees are directed to erase the carbon shields of choices they are certain…

  2. Second Language Tests for Specific Purpose: How Specific?

    ERIC Educational Resources Information Center

    Ricciardi, Joseph S.

    1981-01-01

    This paper discusses certain problems that can arise with respect to the selection of content in the preparation of a test to measure language proficiency for some specific purpose. Forty employees in a defense plant in Montreal, Canada were interviewed in order to specify language needs, to arrive at a precise interpretation of the required…

  3. Metallothionein-like cadmium binding protein in rat testes administered with cadmium and selenium

    SciTech Connect

    Ohta, H.; Seki, Y.; Imamiya, S.

    1988-08-01

    It is well known that the testicular damage caused by acute cadmium toxicity are protected by simultaneous selenium administration with cadmium, and that the cadmium concentration in the testis increases remarkably as compared with that of only cadmium administration. The increased cadmium in the testis was found in the high molecular weight fraction containing selenium, and it has been thought that the shift of cadmium from the low molecular weight fraction to the high molecular weight fraction containing selenium is an important protection mechanism. However, the cadmium concentration in this high molecular weight fraction decreased with time, then re-shifted to the fraction of metallothionein, a low molecular weight protein having a protective effect against cadmium toxicity. While recently studying the cadmium binding protein, like metallothionein, in testes, it has been reported that the amino acid composition of cadmium binding protein in testis is not similar to that of the hepatic metallothionein. The present study was undertaken to clarify the properties of the increased cadmium binding protein in the testis protected by simultaneous selenium administration with cadmium.

  4. Initial validation of a web-based self-administered neuropsychological test battery for older adults and seniors

    PubMed Central

    Hansen, Tor Ivar; Haferstrom, Elise Christina D.; Brunner, Jan F.; Lehn, Hanne; Håberg, Asta Kristine

    2015-01-01

    Introduction: Computerized neuropsychological tests are effective in assessing different cognitive domains, but are often limited by the need of proprietary hardware and technical staff. Web-based tests can be more accessible and flexible. We aimed to investigate validity, effects of computer familiarity, education, and age, and the feasibility of a new web-based self-administered neuropsychological test battery (Memoro) in older adults and seniors. Method: A total of 62 (37 female) participants (mean age 60.7 years) completed the Memoro web-based neuropsychological test battery and a traditional battery composed of similar tests intended to measure the same cognitive constructs. Participants were assessed on computer familiarity and how they experienced the two batteries. To properly test the factor structure of Memoro, an additional factor analysis in 218 individuals from the HUNT population was performed. Results: Comparing Memoro to traditional tests, we observed good concurrent validity (r = .49–.63). The performance on the traditional and Memoro test battery was consistent, but differences in raw scores were observed with higher scores on verbal memory and lower in spatial memory in Memoro. Factor analysis indicated two factors: verbal and spatial memory. There were no correlations between test performance and computer familiarity after adjustment for age or age and education. Subjects reported that they preferred web-based testing as it allowed them to set their own pace, and they did not feel scrutinized by an administrator. Conclusions: Memoro showed good concurrent validity compared to neuropsychological tests measuring similar cognitive constructs. Based on the current results, Memoro appears to be a tool that can be used to assess cognitive function in older and senior adults. Further work is necessary to ascertain its validity and reliability. PMID:26009791

  5. A Further Examination of the Effects of Administering the Metropolitan Reading Tests in Spanish and English to Spanish-Speaking School Entrants.

    ERIC Educational Resources Information Center

    Cruz, Sylvia; And Others

    In a study designed to assess effects of administering the Metropolitan Reading Test (MRT) in Spanish versus English, 100 Puerto Rican kindergarten pupils were randomly split into two groups. The MRT was administered in English to one group and in a Spanish translation to the other group. The group who took the Spanish version significantly…

  6. Testing of Badminton-Specific Endurance.

    PubMed

    Madsen, Christian M; Højlyng, Mads; Nybo, Lars

    2016-09-01

    Madsen, CM, Højlyng, M, and Nybo, L. Testing of badminton-specific endurance. J Strength Cond Res 30(9): 2582-2590, 2016-In the present study, a novel intermittent badminton endurance (B-ENDURANCE) test was developed and tested in elite (n = 17) and skilled (n = 9) badminton players and in age-matched physically active men (nonbadminton players; n = 8). In addition, B-ENDURANCE test-retest reproducibility was evaluated in 9 badminton players. The B-ENDURANCE test is an incremental test where each level consists of repeated sequences of badminton-specific actions toward the 4 corners of the court. The subject starts in the center of the court in front of a computer screen and within each sequence, he must, in a randomized order, complete 8 actions as dictated by the computer, providing the audiovisual input and verifying that the appropriate sensor is activated within the allocated time. Recovery time between each sequence is 10 seconds throughout the test, but the time to complete each sequence is gradually decreased until the subjects cannot follow the dictated tempo. The B-ENDURANCE test performance for elite players was better (p ≤ 0.05) compared with the skilled players and nonbadminton players. In addition, the B-ENDURANCE test performance correlated (r = 0.8 and p < 0.0001) with elite players' national single rankings. Test-retest coefficient of variation was 7.9% between the first 2 trials (i.e., without a familiarization trial) but reduced to 2.5% when comparing the second and third trials. In conclusion, the B-ENDURANCE test is relevant for the evaluation of badminton-specific endurance but at least 1 familiarization trial is recommended if the test is used for evaluation of longitudinal changes, e.g., tracking training effects. PMID:26849789

  7. Task specificity of finger dexterity tests.

    PubMed

    Berger, Monique A M; Krul, Arno J; Daanen, Hein A M

    2009-01-01

    Finger dexterity tests are generally used to assess performance decrease due to gloves, cold and pathology. It is generally assumed that the O'Connor and Purdue Pegboard test yield similar results. In this experiment we compared these two tests for dry conditions without gloves, and for dry and wet conditions with two types of Nytril gloves. In line with previous observations, wearing gloves caused a decrease in performance of about 12% for the O'Connor test and 9% for the Purdue test. Wetting the gloves prior to the test had no effect on the Purdue score. However, wetting the gloves increased the O'Connor performance significantly by 11%. The results show that the O'Connor and Purdue tests do not yield similar results and should be used selectively for specific tasks. PMID:18339353

  8. Comparison of Severity Ratings on Norm-Referenced Tests for Children with Specific Language Impairment

    ERIC Educational Resources Information Center

    Spaulding, Tammie J.

    2012-01-01

    Purpose: This study evaluated the consistency in severity classifications for children with language impairment on tests of child language. Methods: The TELD-3 and the UTLD-4 were administered to 16 preschool children with specific language impairment (SLI) and 16 typical controls. The boundaries described in the test manuals were used to assign…

  9. Effects of Informed Item Selection on Test Performance and Anxiety for Examinees Administered a Self-Adapted Test.

    ERIC Educational Resources Information Center

    Plake, Barbara S.; And Others

    1995-01-01

    No significant differences in performance on a self-adapted test or anxiety were found for college students (n=218) taking a self-adapted test who selected item difficulty without any prior information, inspected an item before selecting, or answered a typical item and received performance feedback. (SLD)

  10. Critical tests of the antiparasitic activity of thiabendazole and trichlorfon sequentially administered to horses via stomach tube.

    PubMed

    Lyons, E T; Drudge, J H; Tolliver, S C

    1977-06-01

    Thirteen critical tests were conducted in horses naturally infected with helminths and bots. Single doses of thiabendazole (44 mg/kg of body weight) and trichlorfon (40 mg/kg of body weight) powder formulations were administered as suspensions sequentially given via stomach tube to evaluate the efficacy of the combination against the large parasites of horses. Parasite removal efficacies were 100% against 2nd instar Gasterophilus intestinalis and 2nd and 3rd instar Gasterophilus nasalis and 82 to 100% against 3rd instar G intestinals. There were complete removals of mature and immature Parascaris equorum and mature Oxyuris equi. Removal efficacies against Strongylus vulgaris were 89 to 100% and against Strongylus edentatus, 82 to 100%. Of 2 horses infected with Strongylus equinus, removals were 72 and 100%. Seven of the 13 horses treated had transient, semi-liquid feces during the posttreatment hours 1 through 24. PMID:879569

  11. Static testing and proposed standard specifications

    NASA Technical Reports Server (NTRS)

    Warner, E P

    1920-01-01

    Static tests fall into two groups, the first of which is designed to load all members of the structure approximately in accordance with the worst loads which they carry in flight, while the second is directed to the testing of specific members which are suspected of weakness and which are difficult to analyze mathematically. The nature of the loading in the second type is different for every different test, but the purpose of the first is defined clearly enough to permit the adoption of some standard set of loading specifications, at least for airplanes of normal design. Here, an attempt is made to carry through an analysis leading to such a standard, the goal being the determination of a load which will simultaneously impose on every member of the airplane structure a stress equal to the worst it will carry in flight.

  12. Tests in Print II: An Index to Tests, Test Reviews, and the Literature on Specific Tests.

    ERIC Educational Resources Information Center

    Buros, Oscar K., Ed.

    Tests in Print II is a comprehensive, annotated bibliography of all in-print tests published as separates for use with English-speaking subjects. The 1,155 two-column pages list 2,467 tests in print as of early 1974; 16,574 references through 1971 on specific tests; a reprinting of the 1974 APA-AERA-NCME Standards for Educational andPsychological…

  13. [Specific activity of an UV-inactivated antirabies vaccine made from brain tissue administered in a shortened schedule].

    PubMed

    Morogova, V M; Magazov, R Sh; Gil'dina, S S; Latypova, R G; Shafeeva, R S

    1982-04-01

    The results obtained in the study of the specific potency of rabies vaccine prepared from sheep brain tissue and inactivated by UV irradiation indicate that, even in the presence of the lowest immunogenicity index (0.5), 5-6 injections of the vaccine, made not daily, but at interval of 3 and 7 days, induced the production of antibodies in the titers not lower than those resulting from 14-20 daily injections of the same vaccine or Fermi vaccine. The preparation inactivated by UV irradiation should be introduced for therapy according to the shortened immunization schedule with intervals, taking into account the immunogenicity index. PMID:7080770

  14. A Comparison of the Effects of Computer-Administered Testing, Computer-Based Learning and Lecture Approaches on Learning in an Introductory Biology Course.

    ERIC Educational Resources Information Center

    Collins, M. A. J.; Earle, P.

    1990-01-01

    Investigated the effects of units using computers and computer-administered tests. The greatest benefit was attained by those using the units and attending lectures. Students using both the units and tests did not perform as well as the lecture only group. Explores the correlation between high school grades and the methods. (Author/YP)

  15. An Evaluation of a Self-Instructional Manual for Teaching Individuals How to Administer the Revised ABLA Test

    ERIC Educational Resources Information Center

    Boris, Ashley L.; Awadalla, Nardeen; Martin, Toby L.; Martin, Garry L.; Kaminski, Lauren; Miljkovic, Morena

    2015-01-01

    The Assessment of Basic Learning Abilities (ABLA) is a tool that is used to assess the learning ability of individuals with intellectual disability (ID) and children with autism. The ABLA was recently revised and is now referred to as the ABLA-Revised (ABLA-R). A self-instructional manual was prepared to teach individuals how to administer the…

  16. Comparison Between a Self-Administered and Supervised Version of a Web-Based Cognitive Test Battery: Results From the NutriNet-Santé Cohort Study

    PubMed Central

    Bailet, Marion; Lecoffre, Amandine C; Galan, Pilar; Hercberg, Serge; Amieva, Hélène; Kesse-Guyot, Emmanuelle

    2016-01-01

    Background Dementia is a major public health problem, and repeated cognitive data from large epidemiological studies could help to develop efficient measures of early prevention. Data collection by self-administered online tools could drastically reduce the logistical and financial burden of such large-scale investigations. In this context, it is important to obtain data concerning the comparability of such new online tools with traditional, supervised modes of cognitive assessment. Objective Our objective was to compare self-administration of the Web-based NutriNet-Santé cognitive test battery (NutriCog) with administration by a neuropsychologist. Methods The test battery included four tests, measuring, among others aspects, psychomotor speed, attention, executive function, episodic memory, working memory, and associative memory. Both versions of the cognitive battery were completed by 189 volunteers (either self-administered version first, n=99, or supervised version first, n=90). Subjects also completed a satisfaction questionnaire. Concordance was assessed by Spearman correlation. Results Agreement between both versions varied according to the investigated cognitive task and outcome variable. Spearman correlations ranged between .42 and .73. Moreover, a majority of participants responded that they “absolutely” or “rather” agreed that the duration of the self-administered battery was acceptable (184/185, 99.5%), that the tasks were amusing (162/185, 87.6%), that the instructions were sufficiently detailed (168/185; 90.8%) and understandable (164/185, 88.7%), and that they had overall enjoyed the test battery (182/185, 98.4%). Conclusions The self-administered version of the Web-based NutriCog cognitive test battery provided similar information as the supervised version. Thus, integrating repeated cognitive evaluations into large cohorts via the implementation of self-administered online versions of traditional test batteries appears to be feasible. PMID

  17. Development and Evaluation of Computer-Administered Analytical Questions for the Graduate Record Examinations General Test. GRE Board Professional Report No. 88-06P.

    ERIC Educational Resources Information Center

    Bridgeman, Brent; Rock, Donald A.

    Three new computer-administered item types for the analytical scale of the Graduate Record Examination (GRE) General Test were developed and evaluated. One item type was a free-response version of the current analytical reasoning item type. The second item type was a somewhat constrained free-response version of the pattern identification (or…

  18. 21 CFR 660.54 - Potency tests, specificity tests, tests for heterospecific antibodies, and additional tests for...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... heterospecific antibodies, and additional tests for nonspecific properties. 660.54 Section 660.54 Food and Drugs..., specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties. The...) Specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties....

  19. 21 CFR 660.54 - Potency tests, specificity tests, tests for heterospecific antibodies, and additional tests for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... heterospecific antibodies, and additional tests for nonspecific properties. 660.54 Section 660.54 Food and Drugs..., specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties. The...) Specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties....

  20. 21 CFR 660.54 - Potency tests, specificity tests, tests for heterospecific antibodies, and additional tests for...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... heterospecific antibodies, and additional tests for nonspecific properties. 660.54 Section 660.54 Food and Drugs..., specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties. The...) Specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties....

  1. 21 CFR 660.54 - Potency tests, specificity tests, tests for heterospecific antibodies, and additional tests for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... heterospecific antibodies, and additional tests for nonspecific properties. 660.54 Section 660.54 Food and Drugs..., specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties. The...) Specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties....

  2. 21 CFR 660.54 - Potency tests, specificity tests, tests for heterospecific antibodies, and additional tests for...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... heterospecific antibodies, and additional tests for nonspecific properties. 660.54 Section 660.54 Food and Drugs..., specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties. The...) Specificity tests, tests for heterospecific antibodies, and additional tests for nonspecific properties....

  3. 7 CFR 51.3417 - Optional test for specific gravity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Optional test for specific gravity. 51.3417 Section 51... § 51.3417 Optional test for specific gravity. Tests to determine specific gravity shall be made in... lot with respect to size and quality. The specific gravity for any lot of potatoes shall be...

  4. 7 CFR 51.3417 - Optional test for specific gravity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Optional test for specific gravity. 51.3417 Section 51... § 51.3417 Optional test for specific gravity. Tests to determine specific gravity shall be made in... lot with respect to size and quality. The specific gravity for any lot of potatoes shall be...

  5. Prostate-specific antigen (PSA) blood test

    MedlinePlus

    ... test result cannot diagnose prostate cancer. Only a prostate biopsy can diagnose this cancer. Your provider will look ... infection Recent tests on your bladder (cystoscopy) or prostate (biopsy) Catheter tube recently placed into your bladder to ...

  6. Developing Content-Specific Reading Placement Tests.

    ERIC Educational Resources Information Center

    Behrman, Edward H.

    This paper examines the efficacy of content-general reading tests used to place students into development courses. It argues that the discipline-generic model of comprehension supporting content-general reading tests is challenged by conclusions emerging from studies of schema theory, construction-integration theory, domain-knowledge theory, and…

  7. Single Event Testing on Complex Devices: Test Like You Fly Versus Test-Specific Design Structures

    NASA Technical Reports Server (NTRS)

    Berg, Melanie D.; Label, Kenneth

    2016-01-01

    We present a mechanism for evaluating complex digital systems targeted for harsh radiation environments such as space. Focus is limited to analyzing the single event upset (SEU) susceptibility of designs implemented inside Field Programmable Gate Array (FPGA) devices. Tradeoffs are provided between application-specific versus test-specific test structures.

  8. Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation

    PubMed Central

    McCaffrey, Katherine A.; Jones, Brian; Mabrey, Natalie; Weiss, Bernard; Swan, Shanna H.; Patisaul, Heather B.

    2013-01-01

    Bisphenol A (BPA) is a high volume production chemical used in polycarbonate plastics, epoxy resins, thermal paper receipts, and other household products. The neural effects of early life BPA exposure, particularly to low doses administered orally, remain unclear. Thus, to better characterize the dose range over which BPA alters sex specific neuroanatomy, we examined the impact of perinatal BPA exposure on two sexually dimorphic regions in the anterior hypothalamus, the sexually dimorphic nucleus of the preoptic area (SDN-POA) and the anterioventral periventricular (AVPV) nucleus. Both are sexually differentiated by estradiol and play a role in sex specific reproductive physiology and behavior. Long Evans rats were prenatally exposed to 10, 100, 1000, 10,000 mg/kg bw/day BPA through daily, noninvasive oral administration of dosed-cookies to the dams. Offspring were reared to adulthood. Their brains were collected and immunolabeled for tyrosine hydroxylase (TH) in the AVPV and calbindin (CALB) in the SDN-POA. We observed decreased TH-ir cell numbers in the female AVPV across all exposure groups, an effect indicative of masculinization. In males, AVPV TH-ir cell numbers were significantly reduced in only the BPA 10 and BPA 10,000 groups. SDN-POA endpoints were unaltered in females but in males SDN-POA volume was significantly lower in all BPA exposure groups. CALB-ir was significantly lower in all but the BPA 1000 group. These effects are consistent with demasculinization. Collectively these data demonstrate that early life oral exposure to BPA at levels well below the current No Observed Adverse Effect Level (NOAEL) of 50 mg/kg/day can alter sex specific hypothalamic morphology in the rat. PMID:23500335

  9. Prostate-Specific Antigen (PSA) Test

    MedlinePlus

    ... What are some of the limitations and potential harms of the PSA test for prostate cancer screening? ... has been learned about both the benefits and harms of prostate cancer screening, a number of organizations ...

  10. 7 CFR 51.3417 - Optional test for specific gravity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Optional test for specific gravity. 51.3417 Section 51... specific gravity. Tests to determine specific gravity shall be made in accordance with the procedures set.... The specific gravity for any lot of potatoes shall be the average of at least 3 corrected readings...

  11. 7 CFR 51.3417 - Optional test for specific gravity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Optional test for specific gravity. 51.3417 Section 51... specific gravity. Tests to determine specific gravity shall be made in accordance with the procedures set.... The specific gravity for any lot of potatoes shall be the average of at least 3 corrected readings...

  12. 7 CFR 51.3417 - Optional test for specific gravity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Optional test for specific gravity. 51.3417 Section 51... specific gravity. Tests to determine specific gravity shall be made in accordance with the procedures set.... The specific gravity for any lot of potatoes shall be the average of at least 3 corrected readings...

  13. Culture-Specific Testing: Part II.

    ERIC Educational Resources Information Center

    Journal of Non-White Concerns in Personnel and Guidance, 1982

    1982-01-01

    Contains four articles focusing on the Thematic Apperception Test (TAT) and Themes Concerning Blacks (TCB). Compared use of the TAT and TCB with Black children. Used the TCB and oral history to identify values of older Black adults. Compared TCB and TAT response characteristics in Black males and females. (RC)

  14. Specific welds for test blanket modules

    NASA Astrophysics Data System (ADS)

    Rieth, Michael; Rey, Jörg

    2009-04-01

    Fabrication and assembling test blanket modules needs a variety of different welding techniques. Therefore, an evaluation of plate joining for breeder units by tungsten-inert-gas, laser, and electron beam welding was performed by qualification of relevant mechanical properties like hardness, charpy, and creep strength. The focus was laid on the study of post-weld heat treatments at lowest possible temperatures and for maximum recovery of the joints. The most important result is that thin EUROFER plates may be welded by EB or laser techniques without the necessity of post-welding heat treatments that include an austenitization step.

  15. The BITCH-100: A Culture-Specific Test.

    ERIC Educational Resources Information Center

    Williams, Robert L.

    The aim of this paper is to describe the rationale and evaluation of the Black Intelligence Scale of Cultural Homogeneity (BITCH). A "culture specific" test is used to determine the taker's ability to function symbolically or to think in terms of his own culture and environment. A combination of dialect specific and culture specific tests would…

  16. Model-Based Practice Analysis and Test Specifications.

    ERIC Educational Resources Information Center

    Kane, Michael

    1997-01-01

    Licensure and certification decisions are usually based on a chain of inference from results of a practice analysis to test specifications, the test, examinee performance, and a pass-fail decision. This article focuses on the design of practice analyses and translation of practice analyses results into test specifications. (SLD)

  17. Test and evaluation document for DOT Specification 7A Type A Packaging. Revision 3

    SciTech Connect

    1996-01-30

    The US Department of Energy (DOE) has been conducting, through several of its operating contractors, an evaluation and testing program to qualify Type A radioactive material packagings per US Department of Transportation (DOT) Specification 7A (DOT-7A) of the Code of Federal Regulations (CFR), Title 49, Part 178 (49 CFR 178). The program is currently administered by the DOE, Office of Facility Safety Analysis, DOE/EH-32, at DOE-Headquarters (DOE-HQ) in Germantown, Maryland. This document summarizes the evaluation and testing performed for all of the packagings successfully qualified in this program.

  18. Comparative studies of intracerebroventricularly administered cysteamine and pantethine in different behavioral tests and on brain catecholamines in rats.

    PubMed

    Vécsei, L; Alling, C; Widerlöv, E

    1990-01-01

    In a passive avoidance test, intracerebroventricular administration (post-trial treatment) of the somatostatin-depleting compound cysteamine decreased the avoidance latency of the rats in a dose-related manner, while the effect of pantethine (which is metabolized to cysteamine) was less pronounced. In open-field studies, both compounds decreased the motor activity (ambulation, rearing) of the animals 15 min after the injection followed by a subsequent recuperation of the locomotor depression. Following pantethine, the ambulation increased during the later tests (60 min, 240 min, 24 hr). Cysteamine decreased the noradrenaline and increased the dopamine and dihydroxyphenyl acetic acid content in the hypothalamus, whereas the effects of pantethine were less expressed. Both compounds slightly decreased the striatal noradrenaline and increased the dihydroxyphenyl acetic acid levels at 15 and 60 min after administration. However, contrary to pantethine, 4 hr after treatment with cysteamine, there was a decrease in dihydroxyphenyl acetic acid concentration in this brain region. These findings suggest that both pantethine and cysteamine attenuate passive avoidance latency after intracerebroventricular treatment. The different efficiency of pantethine and its metabolite cysteamine might be connected to the low pantetheinase activity of the brain tissue; however, some direct effects of pantethine cannot be excluded. The different effects of the two compounds on the open-field activity are possibly associated with the diverse effects of the compounds on the striatal dopaminergic neurotransmission. PMID:2241425

  19. Pharmacokinetic and pharmacodynamic testing of marbofloxacin administered as a single injection for the treatment of bovine respiratory disease.

    PubMed

    Vallé, M; Schneider, M; Galland, D; Giboin, H; Woehrlé, F

    2012-12-01

    New approaches in Pharmacokinetic/Pharmacodynamic (PK/PD) integration suggested that marbofloxacin, a fluoroquinolone already licensed for the treatment of bovine respiratory disease at a daily dosage of 2 mg/kg for 3-5 days, would be equally clinically effective at 10 mg/kg once (Forcyl(®)), whilst also reducing the risk of resistance. This marbofloxacin dosage regimen was studied using mutant prevention concentration (MPC), PK simulation, PK/PD integration and an in vitro dynamic system. This system simulated the concentration-time profile of marbofloxacin in bovine plasma established in vivo after a single 10 mg/kg intramuscular dose and killing curves of field isolated Pasteurellaceae strains of high (minimum inhibitory concentration (MIC) MIC ≤ 0.03 μg/mL), average (MIC of 0.12-0.25 μg/mL) and low (MIC of 1 μg/mL) susceptibility to marbofloxacin. The marbofloxacin MPC values were 2- to 4-fold the MIC values for all Mannheimia haemolytica, Pasteurella multocida tested. Marbofloxacin demonstrated a concentration-dependent killing profile with bactericidal activity observed within 1 h for most strains. No resistance development (MIC ≥ 4 μg/mL) was detected in the dynamic tests. Target values for risk of resistance PK/PD surrogates (area under the curve (AUC) AUC(24 h) /MPC and T(>MPC) /T(MSW) ratio) were achieved for all clinically susceptible pathogens. The new proposed dosing regimen was validated in vitro and by PK/PD integration confirming the single-injection short-acting antibiotic concept. PMID:22126438

  20. 46 CFR 91.20-20 - Specific tests and inspections.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CFR 95.15-15. For clean agent fire extinguishing piping, see 46 CFR 95.16-15. (c) For inspection... INSPECTION AND CERTIFICATION Initial Inspection § 91.20-20 Specific tests and inspections. The applicable..., the following specific tests and inspections shall be made by the inspector. (a) For...

  1. 46 CFR 91.20-20 - Specific tests and inspections.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CFR 95.15-15. For clean agent fire extinguishing piping, see 46 CFR 95.16-15. (c) For inspection... INSPECTION AND CERTIFICATION Initial Inspection § 91.20-20 Specific tests and inspections. The applicable..., the following specific tests and inspections shall be made by the inspector. (a) For...

  2. 46 CFR 91.20-20 - Specific tests and inspections.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CFR 95.15-15. For clean agent fire extinguishing piping, see 46 CFR 95.16-15. (c) For inspection... INSPECTION AND CERTIFICATION Initial Inspection § 91.20-20 Specific tests and inspections. The applicable..., the following specific tests and inspections shall be made by the inspector. (a) For...

  3. Development of a Program Specific Locator Test. Final Report.

    ERIC Educational Resources Information Center

    Benn, Robert J.

    A project was undertaken to develop a series of program-specific vocational locator tests (PSVLTs) that would consist of subject-specific questions in three academic disciplines--writing, reading, and mathematics--for use in predicting vocational students' success in their vocational programs. As a prelude to constructing the tests, project staff…

  4. Prostate-specific antigen testing accuracy in community practice

    PubMed Central

    Hoffman, Richard M; Gilliland, Frank D; Adams-Cameron, Meg; Hunt, William C; Key, Charles R

    2002-01-01

    Background Most data on prostate-specific antigen (PSA) testing come from urologic cohorts comprised of volunteers for screening programs. We evaluated the diagnostic accuracy of PSA testing for detecting prostate cancer in community practice. Methods PSA testing results were compared with a reference standard of prostate biopsy. Subjects were 2,620 men 40 years and older undergoing (PSA) testing and biopsy from 1/1/95 through 12/31/98 in the Albuquerque, New Mexico metropolitan area. Diagnostic measures included the area under the receiver-operating characteristic curve, sensitivity, specificity, and likelihood ratios. Results Cancer was detected in 930 subjects (35%). The area under the ROC curve was 0.67 and the PSA cutpoint of 4 ng/ml had a sensitivity of 86% and a specificity of 33%. The likelihood ratio for a positive test (LR+) was 1.28 and 0.42 for a negative test (LR-). PSA testing was most sensitive (90%) but least specific (27%) in older men. Age-specific reference ranges improved specificity in older men (49%) but decreased sensitivity (70%), with an LR+ of 1.38. Lowering the PSA cutpoint to 2 ng/ml resulted in a sensitivity of 95%, a specificity of 20%, and an LR+ of 1.19. Conclusions PSA testing had fair discriminating power for detecting prostate cancer in community practice. The PSA cutpoint of 4 ng/ml was sensitive but relatively non-specific and associated likelihood ratios only moderately revised probabilities for cancer. Using age-specific reference ranges and a PSA cutpoint below 4 ng/ml improved test specificity and sensitivity, respectively, but did not improve the overall accuracy of PSA testing. PMID:12398793

  5. The BITCH-100: A Culture-Specific Test

    ERIC Educational Resources Information Center

    Williams, Robert L.

    1975-01-01

    A description of the rationale and the development of the BITCH-100 (Black Intelligence Test of Cultural Homogeneity), a culture specific test for the American black population. Experimental evidence is reported on the norming and validation of this instrument and suggestions made as to potential advantages over the traditional testing approach as…

  6. A Ratio Test of Interrater Agreement with High Specificity

    ERIC Educational Resources Information Center

    Cousineau, Denis; Laurencelle, Louis

    2015-01-01

    Existing tests of interrater agreements have high statistical power; however, they lack specificity. If the ratings of the two raters do not show agreement but are not random, the current tests, some of which are based on Cohen's kappa, will often reject the null hypothesis, leading to the wrong conclusion that agreement is present. A new test of…

  7. Classroom Test Construction: The Power of a Table of Specifications

    ERIC Educational Resources Information Center

    Fives, Helenrose; DiDonato-Barnes, Nicole

    2013-01-01

    Classroom tests provide teachers with essential information used to make decisions about instruction and student grades. A table of specification (TOS) can be used to help teachers frame the decision making process of test construction and improve the validity of teachers' evaluations based on tests constructed for classroom use. In this article…

  8. Attitudes and factors affecting acceptability of self-administered cervicovaginal sampling for human papillomavirus (HPV) genotyping as an alternative to Pap testing among multiethnic Malaysian women

    PubMed Central

    Ma'som, Mahirah; Bhoo-Pathy, Nirmala; Nasir, Nazrila Hairizan; Bellinson, Jerome; Subramaniam, Shridevi; Ma, Yuntong; Yap, Siew-Hwei; Goh, Pik-Pin; Gravitt, Patti; Woo, Yin Ling

    2016-01-01

    Objective The objective of this study was to determine the attitudes and acceptability of self-administered cervicovaginal sampling compared with conventional physician-acquired Papanicolaou (Pap) smear among multiethnic Malaysian women. Method A cross-sectional study was carried out via interviewer-administered surveys from August 2013 through August 2015 at five government-run, urban health clinics in the state of Selangor. Subjects were participants from an ongoing community-based human papillomavirus (HPV) prevalence study who answered a standard questionnaire before and after self-sampling. The cervicovaginal self-sampling for HPV genotyping was performed using a simple brush (‘Just for Me’; Preventive Oncology International, Hong Kong). Detailed data on sociodemographics, previous Pap smear experience, and attitudes towards self-administered cervicovaginal sampling were collected and analysed. Acceptability was inferred using a five-item Likert scale that included six different subjective descriptives: experience, difficulty, convenience, embarrassment, discomfort or pain, and confidence in collecting one's own sample. Results Of the 839 participants, 47.9% were Malays, followed by 30.8% Indians, 18.8% Chinese and 2.5% from other ethnicities. The median age of the participants was 38 years (IQR 30–48). Some 68.2% of participants indicated a preference for self-sampling over the Pap test, with 95% indicating willingness to follow-up a positive result at the hospital. Age, ethnicity and previous Pap test experience were significant independent factors associated with preference for self-sampling. The older the individual, the less likely they were to prefer self-sampling (adjusted OR 0.94, 95% CI 0.90 to 0.98). The Chinese were less likely to prefer self-sampling (72.6%) than the Malays (85.1%) (adjusted OR 0.57, 95% CI 0.33 to 0.98, p=0.004). Participants who had never undergone a Pap smear were also more likely to prefer self-sampling (88.5%) than

  9. Specific fitness training and testing in competitive sports.

    PubMed

    Müller, E; Benko, U; Raschner, C; Schwameder, H

    2000-01-01

    Improvements of athletic capacity in high-performance sport are mainly achieved through an increase of the quality of training. In physical preparation, the quality of training can be improved by developing highly specific means of training. The aim of this paper is to present three examples of how highly specific means of fitness training of world class athletes can be developed. The first example presents a test profile of specific motor abilities of top class tennis players, the second one deals with the improvement of specific strength training methods for ski jumpers, and the third deals with the development of specific training devices of Alpine ski racers. PMID:10647552

  10. 46 CFR 126.350 - Specific tests and inspections.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 126.350 Specific tests and inspections. (a) The applicable tests and inspections set forth in subpart D of this part must be made during the initial inspection. (b) The...

  11. 46 CFR 126.350 - Specific tests and inspections.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 126.350 Specific tests and inspections. (a) The applicable tests and inspections set forth in subpart D of this part must be made during the initial inspection. (b) The...

  12. 46 CFR 126.350 - Specific tests and inspections.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 126.350 Specific tests and inspections. (a) The applicable tests and inspections set forth in subpart D of this part must be made during the initial inspection. (b) The...

  13. 46 CFR 126.350 - Specific tests and inspections.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 126.350 Specific tests and inspections. (a) The applicable tests and inspections set forth in subpart D of this part must be made during the initial inspection. (b) The...

  14. 46 CFR 126.350 - Specific tests and inspections.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS INSPECTION AND CERTIFICATION Initial Inspection § 126.350 Specific tests and inspections. (a) The applicable tests and inspections set forth in subpart D of this part must be made during the initial inspection. (b) The...

  15. 5. "TEST STAND 13, CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. "TEST STAND 1-3, CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-06; no sheet number within title block. D.O. SERIES 1109/17, Rev. A. Stamped: AS BUILT; NO CHANGES. Date of Revision A: 11/1/50. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-3, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  16. 9. "TEST STAND; STRUCTURAL; CABLE TUNNEL, PLAN, SECTIONS, DETAILS." Specifications ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. "TEST STAND; STRUCTURAL; CABLE TUNNEL, PLAN, SECTIONS, DETAILS." Specifications No. OC1-55-72-(Rev.); Drawing No. 60-09-12; sheet 43 of 148; file no. AF 1320/94, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

  17. 8. "TEST STAND, ARCHITECTURAL, FLOOR PLANS AND SCHEDULES." Specifications No. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. "TEST STAND, ARCHITECTURAL, FLOOR PLANS AND SCHEDULES." Specifications No. ENG-04-353-55-72; Drawing No. 60-0912; sheet 22 of 148; file no. 1320/73. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

  18. Design and validation of a self-administered test to assess bullying (bull-M) in high school Mexicans: a pilot study

    PubMed Central

    2013-01-01

    Background Bullying (Bull) is a public health problem worldwide, and Mexico is not exempt. However, its epidemiology and early detection in our country is limited, in part, by the lack of validated tests to ensure the respondents’ anonymity. The aim of this study was to validate a self-administered test (Bull-M) for assessing Bull among high-school Mexicans. Methods Experts and school teachers from highly violent areas of Ciudad Juarez (Chihuahua, México), reported common Bull behaviors. Then, a 10-item test was developed based on twelve of these behaviors; the students’ and peers’ participation in Bull acts and in some somatic consequences in Bull victims with a 5-point Likert frequency scale. Validation criteria were: content (CV, judges); reliability [Cronbach’s alpha (CA), test-retest (spearman correlation, rs)]; construct [principal component (PCA), confirmatory factor (CFA), goodness-of-fit (GF) analysis]; and convergent (Bull-M vs. Bull-S test) validity. Results Bull-M showed good reliability (CA = 0.75, rs = 0.91; p < 0.001). Two factors were identified (PCA) and confirmed (CFA): “bullying me (victim)” and “bullying others (aggressor)”. GF indices were: Root mean square error of approximation (0.031), GF index (0.97), and normalized fit index (0.92). Bull-M was as good as Bull-S for measuring Bull prevalence. Conclusions Bull-M has a good reliability and convergent validity and a bi-modal factor structure for detecting Bull victims and aggressors; however, its external validity and sensitivity should be analyzed on a wider and different population. PMID:23577755

  19. Item Specifications, Science Grade 8. Blue Prints for Testing Minimum Performance Test.

    ERIC Educational Resources Information Center

    Arkansas State Dept. of Education, Little Rock.

    These item specifications were developed as a part of the Arkansas "Minimum Performance Testing Program" (MPT). There is one item specification for each instructional objective included in the MPT. The purpose of an item specification is to provide an overview of the general content and format of test items used to measure an instructional…

  20. Item Specifications, Science Grade 6. Blue Prints for Testing Minimum Performance Test.

    ERIC Educational Resources Information Center

    Arkansas State Dept. of Education, Little Rock.

    These item specifications were developed as a part of the Arkansas "Minimum Performance Testing Program" (MPT). There is one item specification for each instructional objective included in the MPT. The purpose of an item specification is to provide an overview of the general content and format of test items used to measure an instructional…

  1. Minimum Performance Test: Reading Grade 3, Item Specifications. Blue Prints for Testing.

    ERIC Educational Resources Information Center

    Arkansas State Dept. of Education, Little Rock.

    Developed as part of the Arkansas Minimum Performance Testing Program (MPT), these item specifications relate to the third grade reading minimum performance test. There is one item specification for each instructional objective included in the MPT. Item specifications are intended to provide an overview of the general content and format of test…

  2. Assessing a Critical Aspect of Construct Continuity when Test Specifications Change or Test Forms Deviate from Specifications

    ERIC Educational Resources Information Center

    Liu, Jinghua; Dorans, Neil J.

    2013-01-01

    We make a distinction between two types of test changes: inevitable deviations from specifications versus planned modifications of specifications. We describe how score equity assessment (SEA) can be used as a tool to assess a critical aspect of construct continuity, the equivalence of scores, whenever planned changes are introduced to testing…

  3. 3. "TEST STAND NO. 13, EXCAVATION PLAN & SECTIONS." Specifications ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. "TEST STAND NO. 1-3, EXCAVATION PLAN & SECTIONS." Specifications No. ENG 04-353-50-10; Drawing No. 60-0906; no sheet number within title block; D.O. SERIES 1109/10. Stamped: AS BUILT. No revisions or revision dates. Last work date on this drawing "Checked by EAG, 1/31/49." Though this drawing is specific to Test Stand 1-3, it also illustrates the general methods used for excavation design and retaining wall construction at Test Stand 1-5. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-3, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

  4. A Statistical Approach to Establishing Subsystem Environmental Test Specifications

    NASA Technical Reports Server (NTRS)

    Keegan, W. B.

    1974-01-01

    Results are presented of a research task to evaluate structural responses at various subsystem mounting locations during spacecraft level test exposures to the environments of mechanical shock, acoustic noise, and random vibration. This statistical evaluation is presented in the form of recommended subsystem test specifications for these three environments as normalized to a reference set of spacecraft test levels and are thus suitable for extrapolation to a set of different spacecraft test levels. The recommendations are dependent upon a subsystem's mounting location in a spacecraft, and information is presented on how to determine this mounting zone for a given subsystem.

  5. Administering Eye Medications.

    ERIC Educational Resources Information Center

    Morris, Sara; Michael, Nancy, Ed.

    This module on administering eye medications is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. A brief discussion follows of…

  6. A beverage-specific measure of expectancies for malt liquor: development and initial testing.

    PubMed

    Collins, R Lorraine; Vincent, Paula C; Bradizza, Clara M; Kubiak, Audrey J; Falco, Diana L

    2011-12-01

    Malt liquor (ML) is a unique, high alcohol content beverage marketed to encourage heavy drinking. We developed the Malt Liquor Expectancy Questionnaire (MLEQ), a beverage-specific measure of alcohol expectancies, and examined its association with typical weekly ML use, typical weekly alcohol use, and alcohol problems. Forty positive and 40 negative expectancy items were administered to a sample of 639 young adults who regularly consumed ML. Exploratory and confirmatory factor analyses led to the development of the 30-item MLEQ. The MLEQ consists of two positive (i.e., Social Facilitation and Enjoyment, Enhanced Sexuality) and two negative factors (i.e., Aggression and Negative Consequences; Impairment and Physical Symptoms) that possess good internal consistency, test-retest reliability, and convergent validity. The psychometrically sound MLEQ contributes to the limited research on beverage-specific expectancies and heavy drinking. PMID:21928870

  7. Subsurface barrier demonstration test strategy and performance specification

    SciTech Connect

    Treat, R.L.; Cruse, J.M.

    1994-05-01

    This document was developed to help specify a major demonstration test project of subsurface barrier systems supporting the Tank Waste Remediation System (TWRS) Program. The document focuses discussion on requirements applicable to demonstration of three subsurface barrier concepts: (1) Injected Material, (2) Cryogenic, and (3) Desiccant. Detailed requirements are provided for initial qualification of a technology proposal followed by the pre-demonstration and demonstration test requirements and specifications. Each requirement and specification is accompanied by a discussion of the rationale for it. The document also includes information on the Hanford Site tank farms and related data; the related and currently active technology development projects within the DOE`s EM-50 Program; and the overall demonstration test strategy. Procurement activities and other preparations for actual demonstration testing are on hold until a decision is made regarding further development of subsurface barriers. Accordingly, this document is being issued for information only.

  8. Characterization of the Antigen-Specific CD4+ T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes

    PubMed Central

    Ciabattini, Annalisa; Prota, Gennaro; Christensen, Dennis; Andersen, Peter; Pozzi, Gianni; Medaglini, Donata

    2015-01-01

    The design of heterologous prime-boost vaccine combinations that optimally shape the immune response is of critical importance for the development of next generation vaccines. Here, we tested different prime-boost combinations using the tuberculosis vaccine antigen H56 with CAF01 or CpG ODN 1826 adjuvants, administered by the parenteral and nasal routes. Using peptide-MHC class II tetramers, antigen-specific CD4+ T cells were tracked following primary and booster immunizations. Both parenteral priming with H56 plus CAF01 and nasal priming with H56 plus CpG elicited significant expansion of CD4+ tetramer-positive T cells in the spleen; however, only parenterally primed cells responded to booster immunization. Subcutaneous (SC) priming with H56 and CAF01 followed by nasal boosting with H56 and CpG showed the greater expansion of CD4+ tetramer-positive T cells in the spleen and lungs compared to all the other homologous and heterologous prime-boost combinations. Nasal boosting exerted a recruitment of primed CD4+ T cells into lungs that was stronger in subcutaneously than nasally primed mice, in accordance with different chemokine receptor expression induced by primary immunization. These data demonstrate that SC priming is fundamental for eliciting CD4+ T cells that can be efficiently boosted by the nasal route and results in the recruitment of antigen-experienced cells into the lungs. Combination of different vaccine formulations and routes of delivery for priming and boosting is a strategic approach for improving and directing vaccine-induced immune responses. PMID:26379666

  9. Empirically Derived Test Specifications for the Certified Rehabilitation Counselor Examination

    ERIC Educational Resources Information Center

    Leahy, Michael J.; Chan, Fong; Sung, Connie; Kim, Muwoong

    2013-01-01

    This study examined the major job functions and knowledge domains required for effective rehabilitation counseling practice in today's rapidly changing practice environment to revise and update the test specifications for the Commission on Rehabilitation Counselor Certification examination. This report describes the methodology used in this…

  10. [Sensitivity and specificity of new commercial tests for the detection of specific Echinococcus antibodies].

    PubMed

    Auer, Herbert; Stöckl, Cornelia; Suhendra, Susanne; Schneider, Renate

    2009-10-01

    Cystic echinococcosis (CE), caused by Echinococcus granulosus, and alveolar echinococcosis (AE), caused by E. multilocularis belong to the most serious parasitic diseases. Both forms of echinococcosis occur in Austria; in addition, imported cases are diagnosed and treated regularly in Austria. Diagnosis of echinococcosis is based on clinical symptoms, imaging techniques and particularly on the detection of specific antibodies in serum specimens of patients. For decades several companies have been providing commercial Echinococcus antigens and echinococcosis tests based on different methods, i.e. complement fixation test (CFT) and electrophoretic methods (CIEP, IEP) in the past and enzyme-linked immunosorbent assays (ELISA), western blot assays (WB) and indirect haemagglutination assays (IHA) in recent years. During the last years two studies have been carried out in our laboratory in order to evaluate the sensitivity and specificity of two commercial E. granulosus antigens (the synthetic p176 antigen, arc 5 antigen) and three commercial testkits (IHA from Dade Behring, IHA from Fumouze, ELISA from Novagnost-Dade Behring). Sera of patients with histologically and/or molecular biologically confirmed cystic or alveolar echinococcosis, of patients with other parasitic infections and of healthy people were tested comparatively for specific Echinococcus antibodies. The synthetic p176 antigen proved to be a highly specific but a insensitive antigen, whereas both the indirect haemagglutination assay as well as the Novagnost-ELISA showed a much higher sensitivity but only moderate specificity. Our studies demonstrated that neither the commercial antigens nor the test kits tested should be used as a primary test in a routine laboratory for the diagnosis of cystic echinococcosis or of alveolar echinococcosis. PMID:19915815

  11. Safety and antiviral activity of motavizumab, a respiratory syncytial virus (RSV)-specific humanized monoclonal antibody, when administered to RSV-infected children.

    PubMed

    Lagos, Rosanna; DeVincenzo, John P; Muñoz, Alma; Hultquist, Micki; Suzich, Joann; Connor, Edward M; Losonsky, Genevieve A

    2009-09-01

    Previously healthy children hospitalized with respiratory syncytial virus (RSV) received motavizumab (3, 15, or 30 mg/kg intravenously), an RSV-specific monoclonal antibody, or placebo. Safety, tolerability, motavizumab concentrations, and immunogenicity were assessed. Cultivatable RSV in the upper respiratory tract was significantly reduced with motavizumab compared with placebo day 1 post-treatment. No adverse events were considered motavizumab-related by site investigators. PMID:19636278

  12. Development of a specific anaerobic field test for aerobic gymnastics.

    PubMed

    Alves, Christiano Robles Rodrigues; Borelli, Marcello Tadeu Caetano; Paineli, Vitor de Salles; Azevedo, Rafael de Almeida; Borelli, Claudia Cristine Gomes; Lancha Junior, Antônio Herbert; Gualano, Bruno; Artioli, Guilherme Giannini

    2015-01-01

    The current investigation aimed to develop a valid specific field test to evaluate anaerobic physical performance in Aerobic Gymnastics athletes. We first designed the Specific Aerobic Gymnast Anaerobic Test (SAGAT), which included gymnastics-specific elements performed in maximal repeated sprint fashion, with a total duration of 80-90 s. In order to validate the SAGAT, three independent sub-studies were performed to evaluate the concurrent validity (Study I, n=8), the reliability (Study II, n=10) and the sensitivity (Study III, n=30) of the test in elite female athletes. In Study I, a positive correlation was shown between lower-body Wingate test and SAGAT performance (Mean power: p = 0.03, r = -0.69, CI: -0.94 to 0.03 and Peak power: p = 0.02, r = -0.72, CI: -0.95 to -0.04) and between upper-body Wingate test and SAGAT performance (Mean power: p = 0.03, r = -0.67, CI: -0.94 to 0.02 and Peak power: p = 0.03, r = -0.69, CI: -0.94 to 0.03). Additionally, plasma lactate was similarly increased in response to SAGAT (p = 0.002), lower-body Wingate Test (p = 0.021) and a simulated competition (p = 0.007). In Study II, no differences were found between the time to complete the SAGAT in repeated trials (p = 0.84; Cohen's d effect size = 0.09; ICC = 0.97, CI: 0.89 to 0.99; MDC95 = 0.12 s). Finally, in Study III the time to complete the SAGAT was significantly lower during the competition cycle when compared to the period before the preparatory cycle (p < 0.001), showing an improvement in SAGAT performance after a specific Aerobic Gymnastics training period. Taken together, these data have demonstrated that SAGAT is a specific, reliable and sensitive measurement of specific anaerobic performance in elite female Aerobic Gymnastics, presenting great potential to be largely applied in training settings. PMID:25876039

  13. Development of a Specific Anaerobic Field Test for Aerobic Gymnastics

    PubMed Central

    Paineli, Vitor de Salles; Azevedo, Rafael de Almeida; Borelli, Claudia Cristine Gomes; Lancha Junior, Antônio Herbert; Gualano, Bruno; Artioli, Guilherme Giannini

    2015-01-01

    The current investigation aimed to develop a valid specific field test to evaluate anaerobic physical performance in Aerobic Gymnastics athletes. We first designed the Specific Aerobic Gymnast Anaerobic Test (SAGAT), which included gymnastics-specific elements performed in maximal repeated sprint fashion, with a total duration of 80-90 s. In order to validate the SAGAT, three independent sub-studies were performed to evaluate the concurrent validity (Study I, n=8), the reliability (Study II, n=10) and the sensitivity (Study III, n=30) of the test in elite female athletes. In Study I, a positive correlation was shown between lower-body Wingate test and SAGAT performance (Mean power: p = 0.03, r = -0.69, CI: -0.94 to 0.03 and Peak power: p = 0.02, r = -0.72, CI: -0.95 to -0.04) and between upper-body Wingate test and SAGAT performance (Mean power: p = 0.03, r = -0.67, CI: -0.94 to 0.02 and Peak power: p = 0.03, r = -0.69, CI: -0.94 to 0.03). Additionally, plasma lactate was similarly increased in response to SAGAT (p = 0.002), lower-body Wingate Test (p = 0.021) and a simulated competition (p = 0.007). In Study II, no differences were found between the time to complete the SAGAT in repeated trials (p = 0.84; Cohen’s d effect size = 0.09; ICC = 0.97, CI: 0.89 to 0.99; MDC95 = 0.12 s). Finally, in Study III the time to complete the SAGAT was significantly lower during the competition cycle when compared to the period before the preparatory cycle (p < 0.001), showing an improvement in SAGAT performance after a specific Aerobic Gymnastics training period. Taken together, these data have demonstrated that SAGAT is a specific, reliable and sensitive measurement of specific anaerobic performance in elite female Aerobic Gymnastics, presenting great potential to be largely applied in training settings. PMID:25876039

  14. Benchmark specifications for EBR-II shutdown heat removal tests

    SciTech Connect

    Sofu, T.; Briggs, L. L.

    2012-07-01

    Argonne National Laboratory (ANL) is hosting an IAEA-coordinated research project on benchmark analyses of sodium-cooled fast reactor passive safety tests performed at the Experimental Breeder Reactor-II (EBR-II). The benchmark project involves analysis of a protected and an unprotected loss of flow tests conducted during an extensive testing program within the framework of the U.S. Integral Fast Reactor program to demonstrate the inherently safety features of EBR-II as a pool-type, sodium-cooled fast reactor prototype. The project is intended to improve the participants' design and safety analysis capabilities for sodium-cooled fast reactors through validation and qualification of safety analysis codes and methods. This paper provides a description of the EBR-II tests included in the program, and outlines the benchmark specifications being prepared to support the IAEA-coordinated research project. (authors)

  15. Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests.

    PubMed

    Shan, Guogen; Amei, Amei; Young, Daniel

    2015-01-01

    Sensitivity and specificity are often used to assess the performance of a diagnostic test with binary outcomes. Wald-type test statistics have been proposed for testing sensitivity and specificity individually. In the presence of a gold standard, simultaneous comparison between two diagnostic tests for noninferiority of sensitivity and specificity based on an asymptotic approach has been studied by Chen et al. (2003). However, the asymptotic approach may suffer from unsatisfactory type I error control as observed from many studies, especially in small to medium sample settings. In this paper, we compare three unconditional approaches for simultaneously testing sensitivity and specificity. They are approaches based on estimation, maximization, and a combination of estimation and maximization. Although the estimation approach does not guarantee type I error, it has satisfactory performance with regard to type I error control. The other two unconditional approaches are exact. The approach based on estimation and maximization is generally more powerful than the approach based on maximization. PMID:26366190

  16. TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes.

    PubMed

    McKay, Paul F; King, Deborah F L; Mann, Jamie F S; Barinaga, Guillermo; Carter, Darrick; Shattock, Robin J

    2016-01-01

    The induction of high levels of systemic and mucosal humoral immunity is a key goal for many prophylactic vaccines. However, adjuvant strategies developed in mice have often performed poorly in the clinic. Due to their closer similarity to humans, minipigs may provide a more accurate picture of adjuvant performance. Based on their complementary signalling pathways, we assessed humoral immune responses to model antigens after co-administration with the toll-like receptor 4 (TLR4) stimulator glucopyranosyl lipid adjuvant (GLA-AF) or the TLR7/8 agonist resiquimod (R848) (alone and in combination) via the intradermal (ID), intranasal (IN) or combined routes in the Gottingen minipig animal model. Surprisingly, we discovered that while GLA-AF additively enhanced the adjuvant effect of R848 when injected ID, it abrogated the adjuvant activity of R848 after IN inoculation. We then performed a route comparison study using a CN54 gp140 HIV Envelope model antigen adjuvanted with R848 + GLA-AF (ID) or R848 alone (IN). Animals receiving priming inoculations via one route were then boosted by the alternate route. Although differences were observed in the priming phase (IN or ID), responses converged upon boosting by the alternative route with no observable impact resultant from the order of administration (ID/IN vs IN/ID). Specific IgG responses were measured at a distal mucosal site (vaginal), although there was no evidence of mucosal linkage as these closely reflected serum antibody levels. These data indicate that the complex in vivo cross-talk between innate pathways are likely tissue specific and cannot be predicted by simple in vitro models. PMID:26862758

  17. TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes

    PubMed Central

    McKay, Paul F.; King, Deborah F. L.; Mann, Jamie F. S.; Barinaga, Guillermo; Carter, Darrick; Shattock, Robin J.

    2016-01-01

    The induction of high levels of systemic and mucosal humoral immunity is a key goal for many prophylactic vaccines. However, adjuvant strategies developed in mice have often performed poorly in the clinic. Due to their closer similarity to humans, minipigs may provide a more accurate picture of adjuvant performance. Based on their complementary signalling pathways, we assessed humoral immune responses to model antigens after co-administration with the toll-like receptor 4 (TLR4) stimulator glucopyranosyl lipid adjuvant (GLA-AF) or the TLR7/8 agonist resiquimod (R848) (alone and in combination) via the intradermal (ID), intranasal (IN) or combined routes in the Gottingen minipig animal model. Surprisingly, we discovered that while GLA-AF additively enhanced the adjuvant effect of R848 when injected ID, it abrogated the adjuvant activity of R848 after IN inoculation. We then performed a route comparison study using a CN54 gp140 HIV Envelope model antigen adjuvanted with R848 + GLA-AF (ID) or R848 alone (IN). Animals receiving priming inoculations via one route were then boosted by the alternate route. Although differences were observed in the priming phase (IN or ID), responses converged upon boosting by the alternative route with no observable impact resultant from the order of administration (ID/IN vs IN/ID). Specific IgG responses were measured at a distal mucosal site (vaginal), although there was no evidence of mucosal linkage as these closely reflected serum antibody levels. These data indicate that the complex in vivo cross-talk between innate pathways are likely tissue specific and cannot be predicted by simple in vitro models. PMID:26862758

  18. 14. "SITE WORK, CIVIL, SITE PLAN." Test Area 1120. Specifications ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. "SITE WORK, CIVIL, SITE PLAN." Test Area 1-120. Specifications No. OC2-55-72; Drawing No. 60-09-12; sheet 7 of 148; file no. 1320/58, Rev. C. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338 Rev. C, Date: 16 April 1957. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

  19. A Simple Method for Determining Specific Yield from Pumping Tests

    USGS Publications Warehouse

    Ramsahoye, L.E.; Lang, Solomon Max

    1961-01-01

    A simpler solution which greatly reduces the time necessary to compute the specific yield by the pumping-test method of Remson and Lang (1955) is presented. The method consists of computing the volume of dewatered material in the cone of depression and comparing it with the total volume of discharged water. The original method entails the use of a slowly converging series to compute the volume of dewatered material. The solution given herein is derived directly from Darcy's law.

  20. Relation of test-specific motivation and anxiety to test performance.

    PubMed

    Smith, Lisa F; Smith, Jeffrey K

    2002-12-01

    The relations between consequence of test scores and motivation, anxiety, and test performance were studied with 112 persons in four undergraduate educational psychology courses. Students were given two versions of an hourly course examination that varied in consequence, with one counting for part of their grade and the other not counting. Each student completed the Learning and Study Strategies Inventory prior to taking the examination. Afterwards students completed a measure of test anxiety and test motivation specific to the examination they had just taken. Significant main effects were found for consequence of test with scores for test anxiety, test performance, and test motivation. Also, the subscales showed a consistent pattern of relations with test performance and test anxiety across the two conditions, but not for test motivation for which few relations were found under the condition with no consequence. PMID:12530760

  1. Multiloop Integral System Test (MIST): MIST Facility Functional Specification

    SciTech Connect

    Habib, T F; Koksal, C G; Moskal, T E; Rush, G C; Gloudemans, J R

    1991-04-01

    The Multiloop Integral System Test (MIST) is part of a multiphase program started in 1983 to address small-break loss-of-coolant accidents (SBLOCAs) specific to Babcock and Wilcox designed plants. MIST is sponsored by the US Nuclear Regulatory Commission, the Babcock Wilcox Owners Group, the Electric Power Research Institute, and Babcock and Wilcox. The unique features of the Babcock and Wilcox design, specifically the hot leg U-bends and steam generators, prevented the use of existing integral system data or existing integral facilities to address the thermal-hydraulic SBLOCA questions. MIST was specifically designed and constructed for this program, and an existing facility -- the Once Through Integral System (OTIS) -- was also used. Data from MIST and OTIS are used to benchmark the adequacy of system codes, such as RELAP5 and TRAC, for predicting abnormal plant transients. The MIST Functional Specification documents as-built design features, dimensions, instrumentation, and test approach. It also presents the scaling basis for the facility and serves to define the scope of work for the facility design and construction. 13 refs., 112 figs., 38 tabs.

  2. Phase Startup Initiative Phases 3 and 4 Test Plan and Test Specification ( OCRWM)

    SciTech Connect

    PAJUNEN, A.L.; LANGEVIN, M.J.

    2000-08-07

    Construction for the Spent Nuclear Fuel (SNF) Project facilities is continuing per the Level III Baseline Schedule, and installation of the Fuel Retrieval System (FRS) and Integrated Water Treatment System (IWTS) in K West Basin is now complete. In order to accelerate the project, a phased start up strategy to initiate testing of the FRS and IWTS early in the overall project schedule was proposed (Williams 1999). Wilkinson (1999) expands the definition of the original proposal into four functional testing phases of the Phased Startup Initiative (PSI). Phases 1 and 2 are based on performing functional tests using dummy fuel. This test plan provides overall guidance for Phase 3 and 4 tests, which are performed using actual irradiated N fuel assemblies. The overall objective of the Phase 3 and 4 testing is to verify how the FRS and IWTS respond while processing actual fuel. Conducting these tests early in the project schedule will allow identification and resolution of equipment and process problems before they become activities on the start-up critical path. The specific objectives of this test plan are to: Define the Phase 3 and 4 test scope for the FRS and IWTS; Provide detailed test requirements that can be used to write the specific test procedures; Define data required and measurements to be taken. Where existing methods to obtain these do not exist, enough detail will be provided to define required additional equipment; and Define specific test objectives and acceptance criteria.

  3. 29. "TEST TRACK, STATION '0' THROUGH '200' AREA." Specifications No. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. "TEST TRACK, STATION '0' THROUGH '200' AREA." Specifications No. ENG-OC-1-57-75, Drawing No. AF-6009-15, sheet 53 of 96, D.O. Series No. AF 1394/73, Rev. C. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 5296 Rev. C, Date: 19 NOV 59. Drawing includes plan, section, and details of track. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

  4. Towards sensible toxicity testing for nanomaterials: proposal for the specification of test design

    NASA Astrophysics Data System (ADS)

    Potthoff, Annegret; Weil, Mirco; Meißner, Tobias; Kühnel, Dana

    2015-12-01

    During the last decade, nanomaterials (NM) were extensively tested for potential harmful effects towards humans and environmental organisms. However, a sound hazard assessment was so far hampered by uncertainties and a low comparability of test results. The reason for the low comparability is a high variation in the (1) type of NM tested with regard to raw material, size and shape and (2) procedures before and during the toxicity testing. This calls for tailored, nanomaterial-specific protocols. Here, a structured approach is proposed, intended to lead to test protocols not only tailored to specific types of nanomaterials, but also to respective test system for toxicity testing. There are existing standards on single procedures involving nanomaterials, however, not all relevant procedures are covered by standards. Hence, our approach offers a detailed way of weighting several plausible alternatives for e.g. sample preparation, in order to decide on the procedure most meaningful for a specific nanomaterial and toxicity test. A framework of several decision trees (DT) and flow charts to support testing of NM is proposed as a basis for further refinement and in-depth elaboration. DT and flow charts were drafted for (1) general procedure—physicochemical characterisation, (2) choice of test media, (3) decision on test scenario and application of NM to liquid media, (4) application of NM to the gas phase, (5) application of NM to soil and sediments, (6) dose metrics, (S1) definition of a nanomaterial, and (S2) dissolution. The applicability of the proposed approach was surveyed by using experimental data retrieved from studies on nanoscale CuO. This survey demonstrated the DT and flow charts to be a convenient tool to systematically decide upon test procedures and processes, and hence pose an important step towards harmonisation of NM testing.

  5. Domain-specific functional software testing: A progress report

    NASA Technical Reports Server (NTRS)

    Nonnenmann, Uwe

    1992-01-01

    Software Engineering is a knowledge intensive activity that involves defining, designing, developing, and maintaining software systems. In order to build effective systems to support Software Engineering activities, Artificial Intelligence techniques are needed. The application of Artificial Intelligence technology to Software Engineering is called Knowledge-based Software Engineering (KBSE). The goal of KBSE is to change the software life cycle such that software maintenance and evolution occur by modifying the specifications and then rederiving the implementation rather than by directly modifying the implementation. The use of domain knowledge in developing KBSE systems is crucial. Our work is mainly related to one area of KBSE that is called automatic specification acquisition. One example is the WATSON prototype on which our current work is based. WATSON is an automatic programming system for formalizing specifications for telephone switching software mainly restricted to POTS, i.e., plain old telephone service. Our current approach differentiates itself from other approaches in two antagonistic ways. On the one hand, we address a large and complex real-world problem instead of a 'toy domain' as in many research prototypes. On the other hand, to allow such scaling, we had to relax the ambitious goal of complete automatic programming, to the easier task of automatic testing.

  6. Reliability of the Ekblom soccer-specific endurance test.

    PubMed

    Williams, Morgan D; Wiltshire, Huw D; Lorenzen, Christian; Wilson, Cameron J; Meehan, Daniel L; Cicioni Kolsky, Daniel J

    2009-08-01

    The aim of this study was to explore and quantify measurement reliability of the Ekblom endurance test. Experienced university soccer players (n = 19; age = 20.5 +/- 2.5 years; mass = 80.4 +/- 9.8 kg; and stature = 179.0 +/- 6.0 cm) completed the Ekblom endurance test on 3 separate occasions. Time to complete trial 1 (549 +/- 26 seconds) and trial 2 (547 +/- 26 seconds) was analyzed, and despite no significant difference (F1,18 = 4.119, p = 0.057, etaP = 0.186) between trials, some evidence of systematic bias was observed in the data. Therefore, trial 2 data were compared with those of trial 3 (548 +/- 27 seconds), with trial 1 data removed. The subsequent analysis (F1,18 = 0.740, p = 0.401, etaP = 0.039) showed a reduction in the risk of making a type II error when compared with the previous analysis. From the reliability analyses (3,1 intraclass correlation = 0.983, SEM = +/-3 seconds, smallest worthwhile change = 5 seconds, standard error of prediction [95% confidence intervals] = +/- 9 seconds), a high level of measurement reliability was observed and the sensitivity of the test to monitor changes was "good." In summary, it was shown that a test that involves a variety of soccer-specific forms of locomotion can be highly reliable and sensitive to detect change. In light of the systematic bias found, we do, however, recommend a familiarization session to be scheduled before the introduction of this test. PMID:19593222

  7. Criterion Related Validity of Karate Specific Aerobic Test (KSAT)

    PubMed Central

    Chaabene, Helmi; Hachana, Younes; Franchini, Emerson; Tabben, Montassar; Mkaouer, Bessem; Negra, Yassine; Hammami, Mehrez; Chamari, Karim

    2015-01-01

    Background: Karate is one the most popular combat sports in the world. Physical fitness assessment on a regular manner is important for monitoring the effectiveness of the training program and the readiness of karatekas to compete. Objectives: The aim of this research was to examine the criterion related to validity of the karate specific aerobic test (KSAT) as an indicator of aerobic level of karate practitioners. Patients and Methods: Cardiorespiratory responses, aerobic performance level through both treadmill laboratory test and YoYo intermittent recovery test level 1 (YoYoIRTL1) as well as time to exhaustion in the KSAT test (TE’KSAT) were determined in a total of fifteen healthy international karatekas (i.e. karate practitioners) (means ± SD: age: 22.2 ± 4.3 years; height: 176.4 ± 7.5 cm; body mass: 70.3 ± 9.7 kg and body fat: 13.2 ± 6%). Results: Peak heart rate obtained from KSAT represented ~99% of maximal heart rate registered during the treadmill test showing that KSAT imposes high physiological demands. There was no significant correlation between KSAT’s TE and relative (mL/min kg) treadmill maximal oxygen uptake (r = 0.14; P = 0.69; [small]). On the other hand, there was a significant relationship between KSAT’s TE and the velocity associated with VO2max (vVO2max) (r = 0.67; P = 0.03; [large]) as well as the velocity at VO2 corresponding to the second ventilatory threshold (vVO2 VAT) (r = 0.64; P = 0.04; [large]). Moreover, significant relationship was found between TE’s KSAT and both the total distance covered and parameters of intermittent endurance measured through YoYoIRTL1. Conclusions: The KSAT has not proved to have indirect criterion related validity as no significant correlations have been found between TE’s KSAT and treadmill VO2max. Nevertheless, as correlated to other aerobic fitness variables, KSAT can be considered as an indicator of karate specific endurance. The establishment of the criterion related validity of the KSAT

  8. A Factor Analytic Study of Selected Tests of Specific Components of Academic Learning.

    ERIC Educational Resources Information Center

    Hill, Nancy

    A factor analytic study was designed to examine the factor structure of a battery of 17 tests administered to 100 students at the primary, intermediate, and advanced (grades 7-10) levels and to determine differences in factor structures for the three groups. The tests, measures of academic achievement, included the Wechsler Intelligence Scale for…

  9. The current state of prostate-specific antigen testing.

    PubMed

    Lewis, Ryan; Hornberger, Brad

    2016-09-01

    Since prostate-specific antigen (PSA) testing was approved in 1994, the incidence of metastasis and mortality from prostate cancer have significantly decreased. However, PSA screening for prostate cancer has limitations and few large randomized controlled trials have been conducted to determine the mortality benefit of PSA screening. Two studies that have been conducted are the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial and the European Randomized Study of Screening for Prostate Cancer (ERSPC). These were the two main studies the US Preventive Services Task Force (USPSTF) used in its recommendation against prostate cancer screening in 2012. However, new evidence has demonstrated that the PLCO trial had significant limitations and the results of the ERSPC trial were more significant than previously thought. This article describes the strengths and weaknesses of the USPSTF's recommendation, along with current guidelines for prostate cancer screening. PMID:27575906

  10. 40 CFR Appendix E to Part 52 - Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....7Reference method. Method 2 as delineated in 40 CFR Part 60. 4. Measurement system performance specifications... tube which uses the flow direction of the test gas, then the following test shall be followed and a..., Specification Test Procedures for Monitoring Systems for Effluent Stream Gas Volumetric Flow Rate E Appendix...

  11. 40 CFR Appendix E to Part 52 - Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....7Reference method. Method 2 as delineated in 40 CFR Part 60. 4. Measurement system performance specifications... tube which uses the flow direction of the test gas, then the following test shall be followed and a..., Specification Test Procedures for Monitoring Systems for Effluent Stream Gas Volumetric Flow Rate E Appendix...

  12. Pilot test specific test plan for the removal of arsenic Socorro, New Mexico.

    SciTech Connect

    Collins, Sue S.; Aragon, Malynda Jo; Everett, Randy L.; Siegel, Malcolm Dean; Aragon, Alicia R.; Dwyer, Brian P.; Marbury, Justin Luke

    2006-03-01

    Sandia National Laboratories (SNL) is conducting pilot scale evaluations of the performance and cost of innovative drinking water treatment technologies designed to meet the new arsenic maximum contaminant level (MCL) of 10 {micro}g/L (effective January 2006). As currently envisioned, pilots tests may include multiple phases. Phase I tests will involve side-by-side comparisons of several commercial technologies primarily using design parameters suggested by the Vendors. Subsequent tests (Phase II) may involve repeating some of the original tests, testing the same commercial technologies under different conditions and testing experimental technologies or additional commercial technologies. This Pilot Test Specific Test Plan (PTSTP) was written for Phase I of the Socorro Springs Pilot. The objectives of Phase I include evaluation of the treatment performance of five adsorptive media under ambient pH conditions (approximately 8.0) and assessment of the effect of contact time on the performance of one of the media. Addenda to the PTSTP may be written to cover Phase II studies and supporting laboratory studies. The Phase I demonstration began in the winter of 2004 and will last approximately 9 months. The information from the test will help the City of Socorro choose the best arsenic treatment technology for the Socorro Springs well. The pilot demonstration is a project of the Arsenic Water Technology Partnership program, a partnership between the American Water Works Association (AWWA) Research Foundation, SNL, and WERC (A Consortium for Environmental Education and Technology Development).

  13. Odor-Specific Loss of Smell Sensitivity with Age as Revealed by the Specific Sensitivity Test.

    PubMed

    Seow, Yi-Xin; Ong, Peter K C; Huang, Dejian

    2016-07-01

    The perception of odor mixtures plays an important role in human food intake, behavior, and emotions. Decline of smell acuity with normal aging could impact food perception and preferences at various ages. However, since the landmark Smell Survey by National Geographic, little has been elucidated on differences in the onset and extent of loss in olfactory sensitivity toward single odorants. Here, using the Specific Sensitivity test, we show the onset and extent of loss in both identification and detection thresholds of odorants with age are odorant-specific. Subjects of Chinese descent in Singapore (186 women, 95 men), aged 21-80 years, were assessed for olfactory sensitivity of 10 odorants from various odor groups. Notably, subjects in their 70s required 179 times concentration of rose-like odorant (2-phenylethanol) than subjects in the 20s, while thresholds for onion-like 2-methyloxolane-3-thiol only differed by 3 times between the age groups. In addition, identification rate for 2-phenylethanol was negatively correlated with age throughout adult life whereas mushroom-like oct-1-en-3-ol was equally identified by subjects across all ages. Our results demonstrated the girth of differentiated olfactory loss due to normal ageing, which potentially affect overall perception and preferences of odor mixtures with age. PMID:27001718

  14. High-Stakes Tests for Students with Specific Learning Disabilities: Disability-Based Differential Item Functioning

    ERIC Educational Resources Information Center

    Anjorin, Idayatou

    2009-01-01

    Students with learning disabilities are increasingly included in state accountability systems. The purpose of this study was to investigate disability-based differential item functioning (DIF) on a statewide high-stakes mathematics test administered in the Spring of 2003 to all students seeking a high-school diploma in one state in the eastern…

  15. 30 CFR 250.1509 - What must I do when MMS administers or requires hands-on, simulator, or other types of testing?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... hands-on, simulator, or other types of testing? 250.1509 Section 250.1509 Mineral Resources MINERALS... or requires hands-on, simulator, or other types of testing? If MMS or its authorized representative conducts, or requires you or your contractor to conduct hands-on, simulator, or other types of testing,...

  16. Results of a Pilot Test of a Self-Administered Smartphone-Based Treatment System for Alcohol Use Disorders: Usability and Early Outcomes

    PubMed Central

    Dulin, Patrick L.; Gonzalez, Vivian M.; Campbell, Kendra

    2013-01-01

    Background This paper provides results from a pilot study focused on assessing early-stage effectiveness and usability of a smartphone-based intervention system that provides a stand-alone, self-administered intervention option, the Location-Based Monitoring and Intervention for Alcohol Use Disorders (LBMI-A). The LBMI-A provided numerous features for intervening with ongoing drinking, craving, connection with supportive others, managing life problems, high risk location alerting and activity scheduling. Methods Twenty-eight participants, ranging in age from 22 to 45, who met criteria for an alcohol use disorder used an LBMI-A enabled smartphone for 6 weeks. Results Participants indicated the LBMI-A intervention modules were helpful in highlighting alcohol use patterns. Tools related to managing alcohol craving, monitoring consumption, and identifying triggers to drink were rated by participants as particularly helpful. Participants also demonstrated significant reductions in hazardous alcohol use while using the system (56% of days spent hazardously drinking at baseline vs. 25% while using the LBMI-A) and drinks per day diminished by 52%. Conclusions Implications for system improvement as well as suggestions for designing ecological momentary assessment and intervention systems for substance use disorders are discussed. PMID:24821354

  17. Bioavailability of intramuscularly administered tenoxicam.

    PubMed

    Stebler, T; Guentert, T W

    1993-08-01

    Bioavailability of intramuscularly administered tenoxicam relative to single oral and relative to intravenous doses was determined in two separate randomized crossover studies. Twelve healthy volunteers (12 males, age 20-30 years) received a rapid intravenous injection and a single intramuscular dose and 12 other subjects (11 males, 1 female, age 21-25 years) a single oral and a single intramuscular dose of 20 mg of tenoxicam on two different occasions. The wash-out period between the two consecutive treatments was 4 weeks. Plasma concentrations after dosing were determined by a specific HPLC method. Differences in tenoxicam concentration-time profiles after the different routes of administration were limited to the first 2 h after dosing. Later, plasma concentrations were almost superimposable within and across the two studies. The extent of absorption of intramuscularly administered tenoxicam was complete (mean +/- CV per cent: F(abs) 0.99 +/- 20 per cent) with no difference between the two extravascular administrations (F(rel) 0.95 +/- 10 per cent, intramuscular vs oral). After intramuscular administration tenoxicam was more rapidly absorbed compared to the oral dose (Tmax 0.71 h +/- 80 per cent vs 1.4 h +/- 62 per cent; p > 0.05). Peak concentrations after oral and intramuscular administration (Cmax 2.5 mg l-1 +/- 19 per cent vs 2.7 mg l-1 +/- 14 per cent; p < 0.05) were very similar. PMID:8218966

  18. 40 CFR 798.5200 - Mouse visible specific locus test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... test species. (5) Test report. In addition to the reporting requirements as specified under 40 CFR part... significance desired. (iv) Assignment to groups. Animals shall be randomized and assigned to treatment...

  19. 40 CFR 798.5200 - Mouse visible specific locus test.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... test species. (5) Test report. In addition to the reporting requirements as specified under 40 CFR part... significance desired. (iv) Assignment to groups. Animals shall be randomized and assigned to treatment...

  20. 40 CFR 798.5200 - Mouse visible specific locus test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... test species. (5) Test report. In addition to the reporting requirements as specified under 40 CFR part... significance desired. (iv) Assignment to groups. Animals shall be randomized and assigned to treatment...

  1. 40 CFR 798.5200 - Mouse visible specific locus test.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... test species. (5) Test report. In addition to the reporting requirements as specified under 40 CFR part... significance desired. (iv) Assignment to groups. Animals shall be randomized and assigned to treatment...

  2. 40 CFR 798.5200 - Mouse visible specific locus test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... test species. (5) Test report. In addition to the reporting requirements as specified under 40 CFR part... significance desired. (iv) Assignment to groups. Animals shall be randomized and assigned to treatment...

  3. End User Acceptance - Requirements or Specifications, Certification, Testing

    NASA Technical Reports Server (NTRS)

    Jeevarajan, Judith

    2013-01-01

    NASA follows top level safety requirement of two-failure tolerance (t hree levels of controls or design for minimum risk) to all catastroph ic hazards in the design of safe li-ion batteries for space use. ? R igorous development testing at appropriate levels to credible offnominal conditions and review of test data. ? Implement robust design con trols based on test results and test again to confirm safety at the a ppropriate levels. ? Stringent testing of all (100%) flight batteries (from button cells to large batteries).

  4. 40 CFR 86.1375-2007 - Equipment specifications for field testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-Exceed test procedures, use the test procedures and equipment specified in 40 CFR part 1065, subpart J. ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Equipment specifications for field... Exhaust Test Procedures § 86.1375-2007 Equipment specifications for field testing. For testing...

  5. 40 CFR 86.1375-2007 - Equipment specifications for field testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-Exceed test procedures, use the test procedures and equipment specified in 40 CFR part 1065, subpart J. ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Equipment specifications for field... Exhaust Test Procedures § 86.1375-2007 Equipment specifications for field testing. For testing...

  6. 40 CFR 86.1375-2007 - Equipment specifications for field testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-Exceed test procedures, use the test procedures and equipment specified in 40 CFR part 1065, subpart J. ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Equipment specifications for field... Exhaust Test Procedures § 86.1375-2007 Equipment specifications for field testing. For testing...

  7. The Table of Specifications: Insuring Accountability in Teacher Made Tests

    ERIC Educational Resources Information Center

    Notar, Charles E.; Zuelke, Dennis C.; Wilson, Janell D.; Yunker, Barbara D.

    2004-01-01

    Teachers have been in the era of accountability for some time. There is an increased demand for accountability and the use of non-referenced testing with President Bush's "No Child Left Behind" initiatives. However, there is a growing demand for less reliance on standardized tests. Admission decisions to colleges and universities are being made…

  8. Visual Testing: An Experimental Assessment of the Encoding Specificity Hypothesis.

    ERIC Educational Resources Information Center

    DeMelo, Hermes T.; And Others

    This study of 96 high school biology students investigates the effectiveness of visual instruction composed of simple line drawings and printed words as compared to printed-words-only instruction, visual tests, and the interaction between visual or non-visual mode of instruction and mode of testing. The subjects were randomly assigned to be given…

  9. Overview of reduced enrichment fuels: Development, testing, and specification

    SciTech Connect

    Snelgrove, J.L.

    1987-01-01

    The US Reduced Enrichment Research and Test Reactor (RERTR) Program was established in 1978 to provide the technical means to operate research and test reactors with low enrichment uranium (LEU) fuels without significant penalty in experiment performance, operation costs, component modifications, or safety characteristics. This paper discusses relevant developments in fuel developments. 9 refs., 1 tab.

  10. Computer-Based Internet-Hosted Assessment of L2 Literacy: Computerizing and Administering of the Oxford Quick Placement Test in ExamView and Moodle

    NASA Astrophysics Data System (ADS)

    Meurant, Robert C.

    Sorting of Korean English-as-a-Foreign-Language (EFL) university students by Second Language (L2) aptitude allocates students to classes of compatible ability level, and was here used to screen candidates for interview. Paper-and-pen versions of the Oxford Quick Placement Test were adapted to computer-based testing via online hosting using FSCreations ExamView. Problems with their online hosting site led to conversion to the popular computer-based learning management system Moodle, hosted on www.ninehub.com. 317 sophomores were tested online to encourage L2 digital literacy. Strategies for effective hybrid implementation of Learning Management Systems in L2 tertiary education include computer-based Internet-hosted L2 aptitude tests. These potentially provide a convenient measure of student progress in developing L2 fluency, and offer a more objective and relevant means of teacher- and course-assessment than student evaluations, which tend to confuse entertainment value and teacher popularity with academic credibility and pedagogical effectiveness.

  11. Development and evaluation of a self-administered on-line test of memory and attention for middle-aged and older adults

    PubMed Central

    Troyer, Angela K.; Rowe, Gillian; Murphy, Kelly J.; Levine, Brian; Leach, Larry; Hasher, Lynn

    2014-01-01

    There is a need for rapid and reliable Internet-based screening tools for cognitive assessment in middle-aged and older adults. We report the psychometric properties of an on-line tool designed to screen for cognitive deficits that require further investigation. The tool is composed of measures of memory and executive attention processes known to be sensitive to brain changes associated with aging and with cognitive disorders that become more prevalent with age. Measures included a Spatial Working Memory task, Stroop Interference task, Face-Name Association task, and Number-Letter Alternation task. Normative data were collected from 361 healthy adults age 50–79 who scored in the normal range on a standardized measure of general cognitive ability. Participants took the 20-minute on-line test on their home computers, and a subset of 288 participants repeated the test 1 week later. Analyses of the individual tasks indicated adequate internal consistency, construct validity, test-retest reliability, and alternate version reliability. As expected, scores were correlated with age. The four tasks loaded on the same principle component. Demographically-corrected z-scores from the individual tasks were combined to create an overall score, which showed good reliability and classification consistency. These results indicate the tool may be useful for identifying middle-aged and older adults with lower than expected scores who may benefit from clinical evaluation of their cognition by a health care professional. PMID:25540620

  12. 30 CFR 7.86 - Test equipment and specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... tunnel shall have the following specifications: (i) Be small enough in diameter to cause turbulent flow... exhaust pipe. (i) The probe length shall be at least 80 percent of the diameter of the exhaust pipe. (ii... feet (0.5 meters) or 3 times the diameter of the exhaust pipe, whichever is the larger, from...

  13. 40 CFR Appendix E to Part 52 - Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent Stream Gas Volumetric Flow Rate E Appendix E to Part 52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION...

  14. 40 CFR Appendix E to Part 52 - Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent Stream Gas Volumetric Flow Rate E Appendix E to Part 52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION...

  15. Innovative Technology For Testing Of Protective Gloves Specific Performances

    NASA Astrophysics Data System (ADS)

    Păun, Florin Adrian; Părăian, Mihaela; Jurca, Adrian; Lupu, Leonard; Berzan, Muntean Florina

    2015-07-01

    Presence of hazards along carrying on the work tasks by operators require making use of personal protective equipment, adequate from ensuring protection standpoint. Protecting workers against hazards implies the personal protective equipment to fulfill certain constructional and safety requirements which are very important for the level of protection that should be ensured. This paperwork aims at identifying the constructional and safety requirements for hand protection equipment, as well as the applicable test methods whose results would allow their farther characterization regarding the protection ensured. Innovative solutions are presented, regarding the test stand for determining the blade cut resistance of protective gloves.

  16. An Investigation to Validate the Grammar and Phonology Screening (GAPS) Test to Identify Children with Specific Language Impairment

    PubMed Central

    van der Lely, Heather K. J.; Payne, Elisabeth; McClelland, Alastair

    2011-01-01

    Background The extraordinarily high incidence of grammatical language impairments in developmental disorders suggests that this uniquely human cognitive function is “fragile”. Yet our understanding of the neurobiology of grammatical impairments is limited. Furthermore, there is no “gold-standard” to identify grammatical impairments and routine screening is not undertaken. An accurate screening test to identify grammatical abilities would serve the research, health and education communities, further our understanding of developmental disorders, and identify children who need remediation, many of whom are currently un-diagnosed. A potential realistic screening tool that could be widely administered is the Grammar and Phonology Screening (GAPS) test – a 10 minute test that can be administered by professionals and non-professionals alike. Here we provide a further step in evaluating the validity and accuracy (sensitivity and specificity) of the GAPS test in identifying children who have Specific Language Impairment (SLI). Methods and Findings We tested three groups of children; two groups aged 3;6–6:6, a typically developing (n = 30) group, and a group diagnosed with SLI: (n = 11) (Young (Y)-SLI), and a further group aged 6;9–8;11 with SLI (Older (O)-SLI) (n = 10) who were above the test age norms. We employed a battery of language assessments including the GAPS test to assess the children's language abilities. For Y-SLI children, analyses revealed a sensitivity and specificity at the 5th and 10th percentile of 1.00 and 0.98, respectively, and for O-SLI children at the 10th and 15th percentile .83 and .90, respectively. Conclusions The findings reveal that the GAPS is highly accurate in identifying impaired vs. non-impaired children up to 6;8 years, and has moderate-to-high accuracy up to 9 years. The results indicate that GAPS is a realistic tool for the early identification of grammatical abilities and impairment in young children. A larger

  17. Intravenously administered nanoparticles increase survival following blast trauma

    PubMed Central

    Lashof-Sullivan, Margaret M.; Shoffstall, Erin; Atkins, Kristyn T.; Keane, Nickolas; Bir, Cynthia; VandeVord, Pamela; Lavik, Erin B.

    2014-01-01

    Explosions account for 79% of combat-related injuries, leading to multiorgan hemorrhage and uncontrolled bleeding. Uncontrolled bleeding is the leading cause of death in battlefield traumas as well as in civilian life. We need to stop the bleeding quickly to save lives, but, shockingly, there are no treatments to stop internal bleeding. A therapy that halts bleeding in a site-specific manner and is safe, stable at room temperature, and easily administered is critical for the advancement of trauma care. To address this need, we have developed hemostatic nanoparticles that are administered intravenously. When tested in a model of blast trauma with multiorgan hemorrhaging, i.v. administration of the hemostatic nanoparticles led to a significant improvement in survival over the short term (1 h postblast). No complications from this treatment were apparent out to 3 wk. This work demonstrates that these particles have the potential to save lives and fundamentally change trauma care. PMID:24982180

  18. Teaching Students to Administer the WISC

    ERIC Educational Resources Information Center

    Ritter, Kathleen Yost

    1977-01-01

    A college level psychology course is described in which students were trained by both traditional and experimental methods to administer individual intelligence tests. Comparative analysis of performance by each group indicates that student motivation and performance is not greatly influenced by teaching method and that videotape demonstrations…

  19. Specification and testing for power by wire aircraft

    NASA Technical Reports Server (NTRS)

    Hansen, Irving G.; Kenney, Barbara H.

    1993-01-01

    A power by wire aircraft is one in which all active functions other than propulsion are implemented electrically. Other nomenclature are 'all electric airplane,' or 'more electric airplane.' What is involved is the task of developing and certifying electrical equipment to replace existing hydraulics and pneumatics. When such functions, however, are primary flight controls which are implemented electrically, new requirements are imposed that were not anticipated by existing power system designs. Standards of particular impact are the requirements of ultra-high reliability, high peak transient bi-directional power flow, and immunity to electromagnetic interference and lightning. Not only must the electromagnetic immunity of the total system be verifiable, but box level tests and meaningful system models must be established to allow system evaluation. This paper discusses some of the problems, the system modifications involved, and early results in establishing wiring harness and interface susceptibility requirements.

  20. Specification and testing for power by wire aircraft

    NASA Astrophysics Data System (ADS)

    Hansen, Irving G.; Kenney, Barbara H.

    1993-08-01

    A power by wire aircraft is one in which all active functions other than propulsion are implemented electrically. Other nomenclature are 'all electric airplane,' or 'more electric airplane.' What is involved is the task of developing and certifying electrical equipment to replace existing hydraulics and pneumatics. When such functions, however, are primary flight controls which are implemented electrically, new requirements are imposed that were not anticipated by existing power system designs. Standards of particular impact are the requirements of ultra-high reliability, high peak transient bi-directional power flow, and immunity to electromagnetic interference and lightning. Not only must the electromagnetic immunity of the total system be verifiable, but box level tests and meaningful system models must be established to allow system evaluation. This paper discusses some of the problems, the system modifications involved, and early results in establishing wiring harness and interface susceptibility requirements.

  1. 21 CFR 866.5550 - Immunoglobulin (light chain specific) immunological test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Immunoglobulin (light chain specific) immunological test system. 866.5550 Section 866.5550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Test Systems § 866.5550 Immunoglobulin (light chain specific) immunological test system....

  2. 21 CFR 866.5550 - Immunoglobulin (light chain specific) immunological test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Immunoglobulin (light chain specific) immunological test system. 866.5550 Section 866.5550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Test Systems § 866.5550 Immunoglobulin (light chain specific) immunological test system....

  3. 21 CFR 866.5550 - Immunoglobulin (light chain specific) immunological test system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Immunoglobulin (light chain specific) immunological test system. 866.5550 Section 866.5550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Test Systems § 866.5550 Immunoglobulin (light chain specific) immunological test system....

  4. 21 CFR 866.5550 - Immunoglobulin (light chain specific) immunological test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Immunoglobulin (light chain specific) immunological test system. 866.5550 Section 866.5550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Test Systems § 866.5550 Immunoglobulin (light chain specific) immunological test system....

  5. 21 CFR 866.5550 - Immunoglobulin (light chain specific) immunological test system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Immunoglobulin (light chain specific) immunological test system. 866.5550 Section 866.5550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Test Systems § 866.5550 Immunoglobulin (light chain specific) immunological test system....

  6. Test-retest reproducibility of the relative dose response for vitamin A status in Guatemalan adults: issues of diagnostic specificity.

    PubMed

    Morrow, F D; Guerrero, A M; Russell, R M; Dallal, G; Solomons, N W

    1990-07-01

    The relative dose response (RDR) test was examined with regard to specificity and reproducibility in subjects with adequate dietary intake and normal liver reserves of vitamin A. Twelve subjects were administered an RDR test four times over 22 d, including one placebo test in which the oral dose of vitamin A was omitted. Additionally, static measures of retinol, tocopherol, retinol binding protein (RBP) and prealbumin (PAL) were taken to determine the intra- and inter-individual coefficient of variation for these blood constituents. Intra-individual coefficients of variation were as follows: retinol, 8.8%; RBP, 11.5%; PAL, 7.6%; and alpha-tocopherol, 8.8%. The mean RDR in vitamin A-replete subjects was 1.2% and ranged from approximately -25% to 11%. No differences were observed between placebo and true RDR (i.e., with vitamin A) test responses, and there was no difference among the three true RDRs over a period of 22 d. Consistent with the hypothesis upon which the RDR test is based, nascently absorbed vitamin A evidently entered a storage pool in the liver of vitamin A-replete subjects without immediate release to peripheral sites of utilization. Because the RDR test results were normal in all subjects, the procedure appears to offer high test specificity and does not falsely diagnose hypovitaminosis A. Nevertheless, the magnitude and direction of the RDR within an individual over 22 d were highly variable, and this variability may preclude the use of a single measure of the RDR to grade the relative vitamin A nutriture of an individual subject. PMID:2366108

  7. Proceedings of the Advisory Committee on Standardization of Carbon-Phenolic Test Methods and Specifications

    SciTech Connect

    Hall, W.B.

    1990-04-01

    Topics addressed include: Polyacrylonitrile (PAN) activity; low fired PAN fiber program review; carbon fabric oxidation mass loss; gel permeation chromatography (GPC) test methodology; carbon assay testing; and NAR rayon yarn specifications.

  8. Evaluating Specification Tests in the Context of Value-Added Estimation. Working Paper #38

    ERIC Educational Resources Information Center

    Guarino, Cassandra M.; Reckase, Mark D.; Stacy, Brian W.; Wooldridge, Jeffrey M.

    2014-01-01

    We study the properties of two specification tests that have been applied to a variety of estimators in the context of value-added measures (VAMs) of teacher and school quality: the Hausman test for choosing between random and fixed effects and a test for feedback (sometimes called a "falsification test"). We discuss theoretical…

  9. Evaluating Specification Tests in the Context of Value-Added Estimation

    ERIC Educational Resources Information Center

    Guarino, Cassandra M.; Reckase, Mark D.; Stacy, Brian W.; Wooldridge, Jeffrey M.

    2015-01-01

    We study the properties of two specification tests that have been applied to a variety of estimators in the context of value-added measures (VAMs) of teacher and school quality: the Hausman test for choosing between student-level random and fixed effects, and a test for feedback (sometimes called a "falsification test"). We discuss…

  10. Sensitivity of C-Tb: a novel RD-1-specific skin test for the diagnosis of tuberculosis infection.

    PubMed

    Hoff, Soren T; Peter, Jonathan G; Theron, Grant; Pascoe, Mellissa; Tingskov, Pernille N; Aggerbeck, Henrik; Kolbus, Daniel; Ruhwald, Morten; Andersen, Peter; Dheda, Keertan

    2016-03-01

    C-Tb, a novel Mycobacterium tuberculosis and 6-kDa early secretory antigenic target/10-kDa culture filtrate protein (ESAT-6/CFP-10)-specific skin test, has high specificity in bacille Calmette-Guerin-vaccinated healthy controls. However, the sensitivity of C-Tb has hitherto not been determined. The objective was to determine the sensitivity of C-Tb in patients with active tuberculosis (TB) in comparison with the tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFT-GIT).C-Tb and TST were randomly administered in a double-blinded fashion to one or the other forearm in 253 patients with active TB with or without HIV co-infection. QFT-GIT testing was performed prior to skin testing.Using a receiver operating characteristic curve-derived cut-point of 5 mm, C-Tb sensitivity was similar to QFT-GIT (73.9 (95% CI 67.8-79.3) versus 75.1 (95% CI 69.3-80.2)), and similar in HIV-infected and HIV-uninfected patients (76.7 (95% CI 69.0-83.3) versus 69.5 (95% CI 59.2-78.5)). However, sensitivity was significantly diminished in HIV-infected patients with CD4 counts <100 cells·mm(-3). C-Tb and QFT-GIT combined had significantly higher sensitivity than C-Tb alone (p<0.0001). C-Tb was safe with no significant adverse events. The 5 mm cut-point corresponded to that found in the previously published specificity study (TESEC-04).C-Tb has similar sensitivity compared with QFT-GIT for the diagnosis of M. tuberculosis infection. Sensitivity was reduced only in HIV-infected patients with severe immunosuppression. Further studies in different settings are required to validate the proposed 5 mm cut-point. PMID:26677940

  11. Physician-patient discussions about prostate-specific antigen test use among African-American men.

    PubMed Central

    Tannor, Bernice B.; Ross, Louie

    2006-01-01

    BACKGROUND: The purpose of this study was to examine the associations between physician-patient discussions, demographic and health-related variables, and PSA test use. Of the previous studies that examined physician-patient discussions about PSA test use, none focused on African-American men. METHODS: Using a sample of African-American men (N=739) aged > or = 40 years who had participated in the National Health Interview Survey (NHIS) 2000, we assessed demographic, health status and other variables related to two PSA test use outcomes: 1) had a PSA test within the past year, and 2) had > or = 3 PSA tests within the past five years. RESULTS: More than three-fourths (76.6%) of our sample reported that their doctors had discussed with them the advantages and disadvantages of the PSA test before administering it. The bivariate analysis showed a number of variables positively associated with PSA test use including men aged > or = 50, having health insurance coverage and having participated in physician-patient discussions about the test. DISCUSSION: Despite the high percentage of men who had discussions with their doctor, there was a large number of men who had neither heard of nor undergone a PSA test. More efforts should be made by the healthcare community to promote prostate cancer screening education and physician-patient discussions. PMID:16623065

  12. Project W-314 Specific Test and Evaluation Plan 241-AN-B Valve Pit

    SciTech Connect

    HAMMERS, J.S.

    1999-08-25

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities performed on the 241-AN-B Valve Pit for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  13. Project W-314 specific test and evaluation plan for 241-AY-01A pump pit upgrade

    SciTech Connect

    Hays, W.H.

    1998-05-19

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities encompassing the upgrade of the 241-AY-0IA Pump Pit for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AY-01A Pump Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  14. Project W-314 specific test and evaluation plan for 241-AY-02A pump pit upgrade

    SciTech Connect

    Hays, W.H.

    1998-05-19

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities encompassing the upgrade of the 241-AY-02A Pump Pit for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AY-02A Pump Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  15. Second IEA Mathematics Study. Suggested Tables of Specifications for the IEA Mathematics Tests. Working Paper I.

    ERIC Educational Resources Information Center

    International Association for the Evaluation of Educational Achievement, Wellington (New Zealand).

    This working paper presents specifications for the test items to be used in the second mathematics study to be conducted by the International Association for the Evaluation of Educational Achievement (IEA). A content-by-behaviors grid is presented for two population levels, with specifics for each dimension outlines and examples of test items…

  16. Paradata: a new data source from web-administered measures.

    PubMed

    Sowan, Azizeh K; Jenkins, Louise S

    2010-01-01

    Web administration of measures offers numerous advantages as well as some drawbacks; the efficiency of collecting data in this way is dramatic. An important by-product of Web administration of measures is the option of creating paradata that offer information about how respondents access a measure (server-side paradata) and navigate within the online environment (client-side paradata) to complete the measure. Paradata can play a critical role in developing and piloting measures as well as refining the measurement process. Uses of paradata in Web-administered measures include (1) informing the choice of response formats, (2) examining the extent of changing response options, (3) examining the extent of following a prescribed sequence in completing a measure, (4) tracking the response process, (5) aiding in designing a Web-administered measure and its layout, and (6) assisting in determining the most appropriate log-in procedure. Because of the potential value of this new type of useful data to researchers in nursing and health, this article focuses on paradata within the context of Web-administered measures. More specifically, the article focuses on the definition, generation, and uses of paradata, as well as the ethical issues and other concerns in obtaining and using paradata. Uses of paradata to test the usability of information systems used in nursing and health practices are also included. PMID:20978403

  17. Dynamic changes in hypermnesia across early and late tests: a relational/item-specific account.

    PubMed

    McDaniel, M A; Moore, B A; Whiteman, H L

    1998-01-01

    Two experiments tested predictions derived from R. R. Hunt and M. A. McDaniel's (1993) relational/item-specific account of hypermnesia. According to this framework, participants encoding relational information should show greater hypermnesia on early test trials than on later test trials. In contrast, participants encoding item-specific information should show greater hypermnesia on later test trials than on early test trials. These predictions were not anticipated by other accounts but were confirmed by the results. Further, the patterns of reminiscence and intertest forgetting supported the theoretical underpinnings of these predictions. A 3rd experiment examined some factors by which item-specific encoding might enhance reminiscence (and thus hypermnesia) on later test trials. These results suggested that a richer set of encoded attributes rather than a fluctuating retrieval plan supported the beneficial effects of item-specific encoding on reminiscence. PMID:9438958

  18. Negative and Positive Testing Effects in Terms of Item-Specific and Relational Information

    ERIC Educational Resources Information Center

    Mulligan, Neil W.; Peterson, Daniel J.

    2015-01-01

    Though retrieving information typically results in improved memory on a subsequent test (the testing effect), Peterson and Mulligan (2013) outlined the conditions under which retrieval practice results in poorer recall relative to restudy, a phenomenon dubbed the "negative testing effect." The item-specific-relational account proposes…

  19. Development of a force specification for a force-limited random vibration test

    SciTech Connect

    Stevens, R.R.

    1996-02-01

    Vibration testing, techniques have been developed and employed that reduce the overtesting caused by the essentially infinite mechanical impedance of the shaker in conventional vibration tests. With these ``force-limiting`` techniques, two vibration test specifications are used: the conventional acceleration specification, and an interface force specification. The vibration level of the shake table is controlled such that neither the table acceleration nor the force transmitted to the test item exceeds its specification, hence the name ``dual control`` vibration test. The effect of limiting the shake table vibration to the force specification is to reduce (``notch``) the shaker acceleration near some of the test item`s resonance frequencies. Several methods of deriving the force specification have been described in the literature. A new method is proposed in this paper that is based on a modal method of coupling two dynamic systems, in this case the ``source`` or launch vehicle, and the ``load`` or payload. The only information that is required is an experimentally-measurable frequency-response function (FRF) called the dynamic mass for both the source and the load. The method, referred to as the coupled system, modal approach (CSMA) method, is summarized and compared to an existing method of determining the force specification for force-limited vibration testing.

  20. Negative and positive testing effects in terms of item-specific and relational information.

    PubMed

    Mulligan, Neil W; Peterson, Daniel J

    2015-05-01

    Though retrieving information typically results in improved memory on a subsequent test (the testing effect), Peterson and Mulligan (2013) outlined the conditions under which retrieval practice results in poorer recall relative to restudy, a phenomenon dubbed the negative testing effect. The item-specific-relational account proposes that this occurs when retrieval disrupts interitem relational encoding despite enhancing item-specific information. Four experiments examined the negative testing effect, showing the following: (a) The basic phenomenon is replicable in free recall; (b) it extends to category-cued recall; (c) it converts to a positive testing effect when the final test is recognition, a test heavily reliant on item-specific information; (d) the negative testing effect in recall, robust in a pure list design, reverses to a positive testing effect in a mixed-list design; and (e) more generally, the present testing manipulation interacts with experimental design, such that an initially negative effect becomes positive or an initially positive effect becomes larger as the design changes from pure-list to mixed-list. The breadth of results fits well within the item-specific-relational framework and provides evidence against 2 alternative accounts. Finally, this research indicates that the testing effect shares important similarities with the generation effect and other similar memory phenomena. PMID:25181496

  1. Project W-314 specific test and evaluation plan for AZ tank farm upgrades

    SciTech Connect

    Hays, W.H.

    1998-08-12

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made by the addition of the SN-631 transfer line from the AZ-O1A pit to the AZ-02A pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation P1 an (TEP). Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities, etc), Factory Tests and Inspections (FTIs), installation tests and inspections, Construction Tests and Inspections (CTIs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). The STEP will be utilized in conjunction with the TEP for verification and validation.

  2. Hydrogen test of a small, low specific speed centrifugal pump stage

    NASA Technical Reports Server (NTRS)

    1991-01-01

    A small, low specific speed centrifugal pump stage with a 2 inch tip diameter, .030 inch tip width shrouded impeller and volute collector was tested with liquid hydrogen as the pumped fluid. The hydrodynamic design of the pump stage is summarized and the noncavitating and cavitating performance results are presented. Test speeds were 60 and 80 percent of the 77,000 rpm design speed. Liquid hydrogen test results are compared with data from previous tests of the stage in water.

  3. Project W-314 Specific Test and Evaluation Plan 241-AN-A Valve Pit

    SciTech Connect

    HAMMERS, J.S.

    1999-08-25

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  4. Project W-314 specific test and evaluation plan for 241-AN-A valve pit

    SciTech Connect

    Hays, W.H.

    1998-06-25

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  5. Project W-314 specific test and evaluation plan 241-AN-B valve pit

    SciTech Connect

    Hays, W.H.

    1998-04-08

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-B Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP).

  6. Project W-314 Specific Test and Evaluation Plan for 200E Waste Transfer System

    SciTech Connect

    HAMMERS, J.S.

    2000-02-25

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of the newly constructed 200E Waste Transfer System in the W-314 Project. The STEP provides the outline for test and evaluation methods that verify the system's performance and compliance to the established Project design criteria. The STEP is a ''lower tier'' document based on the W-314 Test & Evaluation Plan (TEP).

  7. Communicative Language Testing: Implications for Computer Based Language Testing in French for Specific Purposes

    ERIC Educational Resources Information Center

    García Laborda, Jesús; López Santiago, Mercedes; Otero de Juan, Nuria; Álvarez Álvarez, Alfredo

    2014-01-01

    Current evolutions of language testing have led to integrating computers in FSP assessments both in oral and written communicative tasks. This paper deals with two main issues: learners' expectations about the types of questions in FSP computer based assessments and the relation with their own experience. This paper describes the experience…

  8. Claims, Evidence and Achievement Level Descriptors as a Foundation for Item Design and Test Specifications

    ERIC Educational Resources Information Center

    Hendrickson, Amy; Huff, Kristen; Luecht, Ric

    2009-01-01

    [Slides] presented at the Annual Meeting of National Council on Measurement in Education (NCME) in San Diego, CA in April 2009. This presentation describes how the vehicles for gathering student evidence--task models and test specifications--are developed.

  9. Verification of force and acceleration specifications for random vibration tests of Cassini spacecraft equipment

    NASA Technical Reports Server (NTRS)

    Chang, Kurng Y.; Scharton, Terry D.

    1996-01-01

    The use of force limiting in the random vibration testing of the Cassini spacecraft's subsystems is reported on. A verification of the Cassini equipment random vibration test acceleration and force specifications is provided by interface acceleration and force data measured in acoustic tests of the Cassini spacecraft development test model (DTM). Acoustic tests were performed on the DTM structure with different structural and equipment configurations. The acceleration and force spectra at the interface between the equipment items and the spacecraft DTM structure were measured in the acoustic tests and compared with the equipment random vibration test specifications. The spacecraft's apparent masses were measured at the equipment mounting points and used in force limit predictions.

  10. A closure test for time-specific capture-recapture data

    USGS Publications Warehouse

    Stanley, T.R.; Burnham, K.P.

    1999-01-01

    The assumption of demographic closure in the analysis of capture-recapture data under closed-population models is of fundamental importance. Yet, little progress has been made in the development of omnibus tests of the closure assumption. We present a closure test for time-specific data that, in principle, tests the null hypothesis of closed-population model M(t) against the open-population Jolly-Seber model as a specific alternative. This test is chi-square, and can be decomposed into informative components that can be interpreted to determine the nature of closure violations. The test is most sensitive to permanent emigration and least sensitive to temporary emigration, and is of intermediate sensitivity to permanent or temporary immigration. This test is a versatile tool for testing the assumption of demographic closure in the analysis of capture-recapture data.

  11. Further observations on the specific red cell adherence test: effects of radiation therapy

    SciTech Connect

    Richie, J.P.; Yap, W.T.

    1981-04-01

    To assess the effects of radiation therapy on the specific red cell adherence test we have evaluated 33 patients who underwent cystectomy for bladder cancer and in whom radiotherapy had been used. With this test negative tumors were found in 32 of the 33 cases. In a second series of 10 patients histologic examinations were done by biopsy before radiotherapy and by subsequent microscopic examination of the cystectomy specimen. The specific red cell adherence test results remained constant in all of these cases. These findings strongly suggest that 1) the specific red cell adherence test does remain negative after radiotherapy and 2) this test is a valuable prognosticator of the future likelihood of invasion in all patients with transitional cell carcinoma of the bladder.

  12. The Psychological Construct of Encoding Specificity and Its Relationship to Designing Instruction and Tests.

    ERIC Educational Resources Information Center

    Canelos, James; And Others

    The effects of encoding specificity were evaluated for learners: (1) in a typical classroom group learning environment, (2) receiving an audiovisual presentation on an academic subject, and (3) in a group testing environment. Encoding specificity involves the interaction between the encoding phase of memory or the learning context, the stored…

  13. 49 CFR 180.509 - Requirements for inspection and test of specification tank cars.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... specification tank cars. 180.509 Section 180.509 Transportation Other Regulations Relating to Transportation...) CONTINUING QUALIFICATION AND MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.509 Requirements for inspection and test of specification tank cars. (a) General. Each tank car owner must...

  14. 49 CFR 180.509 - Requirements for inspection and test of specification tank cars.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... specification tank cars. 180.509 Section 180.509 Transportation Other Regulations Relating to Transportation...) CONTINUING QUALIFICATION AND MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.509 Requirements for inspection and test of specification tank cars. (a) General. Each tank car owner must...

  15. Testing Time-Invariance of Variable Specificity in Repeated Measure Designs Using Structural Equation Modeling

    ERIC Educational Resources Information Center

    Raykov, Tenko; Amemiya, Yasuo

    2008-01-01

    A structural equation modeling method for examining time-invariance of variable specificity in longitudinal studies with multiple measures is outlined, which is developed within a confirmatory factor-analytic framework. The approach represents a likelihood ratio test for the hypothesis of stability in the specificity part of the residual term…

  16. On the Use of a Test to Exhaustion Specific to Tennis (TEST) with Ball Hitting by Elite Players

    PubMed Central

    2016-01-01

    Purpose We aimed to a) introduce a new Test to Exhaustion Specific to Tennis (TEST) and compare performance (test duration) and physiological responses to those obtained during the 20-m multistage shuttle test (MSST), and b) determine to which extent those variables correlate with performance level (tennis competitive ranking) for both test procedures. Methods Twenty-seven junior players (8 males, 19 females) members of the national teams of the French Tennis Federation completed MSST and TEST, including elements of the game (ball hitting, intermittent activity, lateral displacement), in a randomized order. Cardiorespiratory responses were compared at submaximal (respiratory compensation point) and maximal loads between the two tests. Results At the respiratory compensation point oxygen uptake (50.1 ± 4.7 vs. 47.5 ± 4.3 mL.min-1.kg-1, p = 0.02), but not minute ventilation and heart rate, was higher for TEST compared to MSST. However, load increment and physiological responses at exhaustion did not differ between the two tests. Players’ ranking correlated negatively with oxygen uptake measured at submaximal and maximal loads for both TEST (r = -0.41; p = 0.01 and -0.55; p = 0.004) and MSST (r = -0.38; P = 0.05 and -0.51; p = 0.1). Conclusion Using TEST provides a tennis-specific assessment of aerobic fitness and may be used to prescribe aerobic exercise in a context more appropriate to the game than MSST. Results also indicate that VO2 values both at submaximal and maximal load reached during TEST and MSST are moderate predictors of players competitive ranking. PMID:27035342

  17. Specific Resistance. Operational Control Tests for Wastewater Facilities. Instructor's Manual [and] Student Workbook.

    ERIC Educational Resources Information Center

    Wooley, John F.

    A commonly used test for determining filterability of conditioned sludge is the specific resistance (Buchner funnel) test. The sludge is filtered through filter paper using a Buchner funnel, and the time needed to obtain a given volume of filtrate (or for cake residue to begin to crack) is measured. The shorter the time, the better the…

  18. Proceedings: Nozzle Initiative Industry Advisory Committee on Standardization of Carbon-Phenolic Test Methods and Specifications

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The proceedings of the meeting is presented in conversational form. Some areas of discussion are as follow: resin advancement at NASA Marshall new technologies studies; NMR studies; SPIP/PAN development summary; computer modeling support; composite testing; carbon assay testing; activity and aerospace computer database; alternate rayon yarn sizing; fiber morphology; and carbon microballoons specifications.

  19. Development of electrical test procedures for qualification of spacecraft against EID. Volume 2: Review and specification of test procedures

    NASA Technical Reports Server (NTRS)

    Wilkenfeld, J. M.; Harlacher, B. L.; Mathews, D.

    1982-01-01

    A combined experimental and analytical program to develop system electrical test procedures for the qualification of spacecraft against damage produced by space-electron-induced discharges (EID) occurring on spacecraft dielectric outer surfaces is described. A review and critical evaluation of possible approaches to qualify spacecraft against space electron-induced discharges (EID) is presented. A variety of possible schemes to simulate EID electromagnetic effects produced in spacecraft was studied. These techniques form the principal element of a provisional, recommended set of test procedures for the EID qualification spacecraft. Significant gaps in our knowledge about EID which impact the final specification of an electrical test to qualify spacecraft against EID are also identified.

  20. 26. "TEST STAND, STRUCTURAL, FOUNDATION PLAN." Specifications No. ENG043535572; Drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. "TEST STAND, STRUCTURAL, FOUNDATION PLAN." Specifications No. ENG-04-353-55-72; Drawing No. 60-0912; sheet 25 of 148; file no. 1320/76. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

  1. Proceedings of the Advisory Committee on standardization of carbon-phenolic test methods and specifications

    NASA Technical Reports Server (NTRS)

    Hall, William B.

    1991-01-01

    Proceedings of the Advisory Committee on Standardization of carbon-phenolic test methods and specifications are compiled. The following subject areas are covered: ashing procedures and alkali metal content of carbon fiber and fabrics; SPIP product identification code; SPIP initiative to adopt a water-soluble rayon yarn lubricant/size for weaving; fabric oxidation mass loss test; shelf life limit for prepregs, industry standard; silicon contamination update; resin, filler, and fabric content in prepreg; carbon assay testing calibration; thiokol rayon specifications; and SPIP low conductivity PAN program.

  2. Domain-General and Domain-Specific Creative-Thinking Tests: Effects of Gender and Item Content on Test Performance

    ERIC Educational Resources Information Center

    Hong, Eunsook; Peng, Yun; O'Neil, Harold F., Jr.; Wu, Junbin

    2013-01-01

    The study examined the effects of gender and item content of domain-general and domain-specific creative-thinking tests on four subscale scores of creative-thinking (fluency, flexibility, originality, and elaboration). Chinese tenth-grade students (234 males and 244 females) participated in the study. Domain-general creative thinking was measured…

  3. Nozzle Initiative Industry Advisory Committee on Standardization of Carbon-Phenolic Test Methods and Specifications

    NASA Technical Reports Server (NTRS)

    Bull, William B. (Compiler); Pinoli, Pat C. (Compiler); Upton, Cindy G. (Compiler); Day, Tony (Compiler); Hill, Keith (Compiler); Stone, Frank (Compiler); Hall, William B.

    1994-01-01

    This report is a compendium of the presentations of the 12th biannual meeting of the Industry Advisory Committee under the Solid Propulsion Integrity Program. A complete transcript of the welcoming talks is provided. Presentation outlines and overheads are included for the other sessions: SPIP Overview, Past, Current and Future Activity; Test Methods Manual and Video Tape Library; Air Force Developed Computer Aided Cure Program and SPC/TQM Experience; Magneto-Optical mapper (MOM), Joint Army/NASA program to assess composite integrity; Permeability Testing; Moisture Effusion Testing by Karl Fischer Analysis; Statistical Analysis of Acceptance Test Data; NMR Phenolic Resin Advancement; Constituent Testing Highlights on the LDC Optimization Program; Carbon Sulfur Study, Performance Related Testing; Current Rayon Specifications and Future Availability; RSRM/SPC Implementation; SRM Test Methods, Delta/Titan/FBM/RSRM; and Open Forum on Performance Based Acceptance Testing -- Industry Experience.

  4. Nozzle Initiative Industry Advisory Committee on Standardization of Carbon-Phenolic Test Methods and Specifications

    NASA Astrophysics Data System (ADS)

    Bull, William B.; Pinoli, Pat C.; Upton, Cindy G.; Day, Tony; Hill, Keith; Stone, Frank; Hall, William B.

    1994-12-01

    This report is a compendium of the presentations of the 12th biannual meeting of the Industry Advisory Committee under the Solid Propulsion Integrity Program. A complete transcript of the welcoming talks is provided. Presentation outlines and overheads are included for the other sessions: SPIP Overview, Past, Current and Future Activity; Test Methods Manual and Video Tape Library; Air Force Developed Computer Aided Cure Program and SPC/TQM Experience; Magneto-Optical mapper (MOM), Joint Army/NASA program to assess composite integrity; Permeability Testing; Moisture Effusion Testing by Karl Fischer Analysis; Statistical Analysis of Acceptance Test Data; NMR Phenolic Resin Advancement; Constituent Testing Highlights on the LDC Optimization Program; Carbon Sulfur Study, Performance Related Testing; Current Rayon Specifications and Future Availability; RSRM/SPC Implementation; SRM Test Methods, Delta/Titan/FBM/RSRM; and Open Forum on Performance Based Acceptance Testing -- Industry Experience.

  5. Preclinical and Clinical Performance of the Efoora Test, a Rapid Test for Detection of Human Immunodeficiency Virus-Specific Antibodies

    PubMed Central

    Arens, Max Q.; Mundy, Linda M.; Amsterdam, Daniel; Barrett, J. Tom; Bigg, Dan; Bruckner, David; Hanna, Bruce; Prince, Harry; Purington, Timothy; Hanna, Todd; Hewitt, Ross; Kalinka, Carolyn; Koppes, Thomas; Maxwell, Sarz; Moe, Ardis; Doymaz, Mehmet; Poulter, Melinda; Saber-Tehrani, Maryam; Simard, Lorenzo; Wilkins-Carmody, Donna; Vidaver, John; Berger, Cheryl; Davis, Alan H.; Alzona, Mortimer T.

    2005-01-01

    Barriers to effective diagnostic testing for human immunodeficiency virus type 1 (HIV-1) infection can be reduced with simple, reliable, and rapid detection methods. Our objective was to determine the accuracy, sensitivity, and specificity of a new rapid, lateral-flow immunochromatographic HIV-1 antibody detection device. Preclinical studies were performed using seroconversion, cross-reaction, and interference panels, archived clinical specimens, and fresh whole blood. In a multicenter, prospective clinical trial, a four-sample matrix of capillary (fingerstick) whole-blood specimens and venous whole blood, plasma, and serum was tested for HIV-1 antibodies with the Efoora HIV rapid test (Efoora Inc., Buffalo Grove, IL) and compared with an enzyme immunoassay (EIA) (Abbott Laboratories) licensed by the Food and Drug Administration. Western blot and nucleic acid test supplemental assays were employed to adjudicate discordant samples. Preclinical testing of seroconversion panels showed that antibodies were often detected earlier by the rapid test than by a reference EIA. No significant interference or cross-reactions were observed. Testing of 4,984 archived specimens yielded a sensitivity of 99.2% and a specificity of 99.7%. A prospective multicenter clinical study with 2,954 adult volunteers demonstrated sensitivity and specificity for the Efoora HIV rapid test of 99.8% (95% confidence interval [CI], 99.3 and 99.98%) and 99.0% (95% CI, 98.5 and 99.4%), respectively. Reactive rapid HIV-1 antibody detection was confirmed in 99.6% of those with a known HIV infection (n = 939), 5.2% of those in the high-risk group (n = 1,003), and 0.1% of those in the low-risk group (n = 1,012). For 21 (0.71%) patients, there was discordance between the results of the rapid test and the confirmatory EIA/Western blot tests. We conclude that the Efoora HIV rapid test is a simple, rapid assay for detection of HIV-1 antibodies, with high sensitivity and specificity compared to a standardized

  6. DEVELOPMENT OF BURN TEST SPECIFICATIONS FOR FIRE PROTECTION MATERIALS IN RAM PACKAGES

    SciTech Connect

    Gupta, N.

    2010-03-03

    The regulations in 10 CFR 71 require that the radioactive material (RAM) packages must be able to withstand specific fire conditions given in 10 CFR 71.73 during Hypothetical Accident Conditions (HAC). This requirement is normally satisfied by extensive testing of full scale test specimens under required test conditions. Since fire test planning and execution is expensive and only provides a single snapshot into a package performance, every effort is made to minimize testing and supplement tests with results from computational thermal models. However, the accuracy of such thermal models depends heavily on the thermal properties of the fire insulating materials that are rarely available at the regulatory fire temperatures. To the best of authors knowledge no test standards exist that could be used to test the insulating materials and derive their thermal properties for the RAM package design. This paper presents a review of the existing industry fire testing standards and proposes testing methods that could serve as a standardized specification for testing fire insulating materials for use in RAM packages.

  7. Identification and characteristics of the testes-specific gene, Ccdc38, in mice.

    PubMed

    Lin, Shou-Ren; Li, Yu-Chi; Luo, Man-Ling; Guo, Huan; Wang, Tian-Tian; Chen, Jian-Bo; Ma, Qian; Gu, Yan-Li; Jiang, Zhi-Mao; Gui, Yao-Ting

    2016-08-01

    Distinguishing the testes-specific genes in different species may disclose key genes associated with testes-specific functions and provide sufficient information for the study and treatment of male infertility. A testes‑specific gene, coiled-coil domain containing 38 (Ccdc38), was identified by screening UniGene libraries. Systematic bioinformatics analysis demonstrated that the CCDC38 protein was conserved in various mammalian species. It was determined that CCDC38 was exclusively expressed in testes and its expression increased from 2‑8 weeks of age. Additional immunohistochemical analysis indicated that CCDC38 was mainly expressed in spermatogonia and spermatocytes. It is of note that, immunofluorescence and co-immunoprecipitation assays demonstrated that CCDC38 interacted with ubiquitinated histone H2A in mouse testes. Therefore, these results suggest that Ccdc38 is a testes-specific gene, which may be important for mouse spermatogenesis. PMID:27278724

  8. Use of a Canal-Drawdown Test to Calculate the Specific Yield of the Biscayne Aquifer

    NASA Astrophysics Data System (ADS)

    Bolster, C. H.; Genereux, D. P.; Saiers, J. E.

    2002-05-01

    Data from a large-scale canal-drawdown test were used to estimate the specific yield (sy) of the Biscayne Aquifer. The drawdown test involved dropping the water level in a nearby canal by about 30 cm and monitoring the response of hydraulic head in the surrounding aquifer. Specific yield was determined by analyzing data from the unsteady portion of the drawdown test using an analytical stream-aquifer interaction model. Specific yield values computed from drawdown at individual piezometers ranged from 0.050 to 0.57, with a mean value of 0.15. The mean value for specific yield was incorporated into a large scale two-dimensional numerical MODFLOW-based groundwater flow model and predictions of head were made during a 183-day period at 4 wells located 337-2546 m from the canal. There was good agreement between the observed and predicted heads, indicating our estimate of specific yield is representative of the large portion of the Biscayne Aquifer studied here. This work represents a practical and novel approach to the determination of a key hydrogeological parameter for a highly transmissive limestone aquifer, in which execution of a traditional pump test would be impractical. Accurate estimates of specific yield and other hydrogeological parameters are critical for management of water supply, Everglades environmental restoration, flood control, and other issues related to the groundwater hydrology of the Biscayne Aquifer.

  9. Are multiple choice tests fair to medical students with specific learning disabilities?

    PubMed

    Ricketts, Chris; Brice, Julie; Coombes, Lee

    2010-05-01

    The purpose of multiple choice tests of medical knowledge is to estimate as accurately as possible a candidate's level of knowledge. However, concern is sometimes expressed that multiple choice tests may also discriminate in undesirable and irrelevant ways, such as between minority ethnic groups or by sex of candidates. There is little literature to establish whether multiple choice tests may also discriminate against students with specific learning disabilities (SLDs), in particular those with a diagnosis of dyslexia, and whether the commonly-used accommodations allow such students to perform up to their capability. We looked for evidence to help us determine whether multiple choice tests could be relied upon to test all medical students fairly, regardless of disability. We analyzed the mean scores of over 900 undergraduate medical students on eight multiple-choice progress tests containing 1,000 items using a repeated-measures analysis of variance. We included disability, gender and ethnicity as possible explanatory factors, as well as year group. There was no significant difference between mean scores of students with an SLD who had test accommodations and students with no SLD and no test accommodation. Virtually all students were able to complete the tests within the allowed time. There were no significant differences between the mean scores of known minority ethnic groups or between the genders. We conclude that properly-designed multiple-choice tests of medical knowledge do not systematically discriminate against medical students with specific learning disabilities. PMID:19763855

  10. Prostate-specific antigen testing in inner London general practices: are those at higher risk most likely to get tested?

    PubMed Central

    Nderitu, Paul; Van Hemelrijck, Mieke; Ashworth, Mark; Mathur, Rohini; Hull, Sally; Dudek, Alexandra; Chowdhury, Simon

    2016-01-01

    Objectives To investigate the association between factors influencing prostate-specific antigen (PSA) testing prevalence including prostate cancer risk factors (age, ethnicity, obesity) and non-risk factors (social deprivation and comorbidity). Setting A cross-sectional database of 136 inner London general practices from 1 August 2009 to 31 July 2014. Participants Men aged ≥40 years without prostate cancer were included (n=150 481). Primary outcome Logistic regression analyses were used to estimate the association between PSA testing and age, ethnicity, social deprivation, body mass index (BMI) and comorbidity while adjusting for age, benign prostatic hypertrophy, prostatitis and tamsulosin or finasteride use. Results PSA testing prevalence was 8.2% (2013–2014), and the mean age was 54 years (SD 11). PSA testing was positively associated with age (OR 70–74 years compared to 40–44 years: 7.34 (95% CI 6.82 to 7.90)), ethnicity (black) (OR compared to white: 1.78 (95% CI 1.71 to 1.85)), increasing BMI and cardiovascular comorbidity. Testing was negatively associated with Chinese ethnicity and with increasing social deprivation. Conclusions PSA testing among black patients was higher compared to that among white patients, which differs from lower testing rates seen in previous studies. PSA testing was positively associated with prostate cancer risk factors and non-risk factors. Association with non-risk factors may increase the risk of unnecessary invasive diagnostic procedures. PMID:27406644

  11. A Rapid In-Clinic Test Detects Acute Leptospirosis in Dogs with High Sensitivity and Specificity.

    PubMed

    Kodjo, Angeli; Calleja, Christophe; Loenser, Michael; Lin, Dan; Lizer, Joshua

    2016-01-01

    A rapid IgM-detection immunochromatographic test (WITNESS® Lepto, Zoetis) has recently become available to identify acute canine leptospirosis at the point of care. Diagnostic sensitivity and specificity of the test were evaluated by comparison with the microscopic agglutination assay (MAT), using a positive cut-off titer of ≥800. Banked serum samples from dogs exhibiting clinical signs and suspected leptospirosis were selected to form three groups based on MAT titer: (1) positive (n = 50); (2) borderline (n = 35); and (3) negative (n = 50). Using an analysis to weight group sizes to reflect French prevalence, the sensitivity and specificity were 98% and 93.5% (88.2% unweighted), respectively. This test rapidly identifies cases of acute canine leptospirosis with high levels of sensitivity and specificity with no interference from previous vaccination. PMID:27110562

  12. A Rapid In-Clinic Test Detects Acute Leptospirosis in Dogs with High Sensitivity and Specificity

    PubMed Central

    Kodjo, Angeli; Calleja, Christophe; Loenser, Michael; Lin, Dan; Lizer, Joshua

    2016-01-01

    A rapid IgM-detection immunochromatographic test (WITNESS® Lepto, Zoetis) has recently become available to identify acute canine leptospirosis at the point of care. Diagnostic sensitivity and specificity of the test were evaluated by comparison with the microscopic agglutination assay (MAT), using a positive cut-off titer of ≥800. Banked serum samples from dogs exhibiting clinical signs and suspected leptospirosis were selected to form three groups based on MAT titer: (1) positive (n = 50); (2) borderline (n = 35); and (3) negative (n = 50). Using an analysis to weight group sizes to reflect French prevalence, the sensitivity and specificity were 98% and 93.5% (88.2% unweighted), respectively. This test rapidly identifies cases of acute canine leptospirosis with high levels of sensitivity and specificity with no interference from previous vaccination. PMID:27110562

  13. [Efficiency and specificity of the KAT-test for rapid diagnosis of falciparum malaria].

    PubMed

    Cong, Le Dinh; Sergiev, V P; Rabinovich, S A; Nhah, Doan Hanh; Huong, Nguyen Van; Morozov, E N; Kukina, I V; Thinh, Ta Thi; Maksakovskaia, E V; Dao, Le Minh; Chalyĭ, V F; To, Dang Thi; Fandeev, V A; Hoa, Ngo Viet; Due, Nguyen Thi

    2002-01-01

    A new rapid KAT Quick Malaria test for the diagnosis of falciparum malaria, which is based on the detection of a monoclonal antibody-antigen complex of malaria parasites, has been worked out by the KAT Medical CC in South Africa. The efficiency and specificity of the KAT test were compared with those of the microscopic method and with the ICT test for rapid diagnosis of P. falciparum and P. vivax. The polymerase chain reaction was used as a control test. Testing for malaria was performed on 98 blood samples from feverish patients in Vietnam and Tadjikistan and among the persons who had returned to Moscow from endemic regions. The efficiency of the KAT test for falciparum-malaria was found to be 100% versus 90.5% with ICT. The absence of cross-reactions with P. vivax and the presence of pseudopositive results of the KAT test for fever cases of non-malaria origin indicate its high specificity. There was no correlation between the rate of test line colouring and the level of parasitemia. The KAT test yielded positive results only when gametocytes were found in blood specimens. PMID:12214515

  14. Development of a Sports Specific Aerobic Capacity Test for Karate - A Pilot Study

    PubMed Central

    Nunan, David

    2006-01-01

    The purpose of the study was to develop an aerobic fitness assessment test for competitive Karate practitioners and describe the preliminary findings. Five well-trained, competitive Karate practitioners participated in this study. A protocol simulating common attack strikes used in competition Karate sparring was developed from video analysis. In addition, pilot testing established a specific sequence of strikes and timings to be used in the test. The time to perform the strike sequence remained the same, whilst the time between strike sequence performances was progressively reduced. The aim of the test was to increase intensity of exercise through a decrease in recovery. On two separate occasions, absolute and relative peak oxygen uptake (VO2peak), peak ventilation (VEpeak), maximum heart rate (HRM), and time to exhaustion (TE) obtained during the test were recorded. Subjective feedback provided by the participants was positive in that participants felt the test accurately simulated actions of a competitive sparring situation, and as a result athletes felt more motivated to perform well on this test. There was no significant between test difference in absolute VO2peak, relative VO2peak, HRM and TE (p > 0.05), indicating a potentially high reproducibility with the new test for these variables (test 1-test 2 difference of 0.04 L·min-1, 1 ml·kg-1·min-1, -3 beats·min-1, and 28 s; respectively). However, VEpeak displayed potentially less reproducibility due to a significant difference observed between tests (test 1- test 2 difference of -2.8 L·min-1, p < 0.05). There was a significant relationship between TE and relative VO2peak (R2 = 0.77, p < 0.001). Further developments to the test will need to address issues with work rate/force output assessment/monitoring. The new test accurately simulates the actions of competitive Karate sparring. Key Points This is the first attempt at an aerobic fitness test specific to competitive Karate practitioners Anecdotal reports

  15. Sensitivity and specificity of parallel or serial serological testing for detection of canine Leishmania infection

    PubMed Central

    de Arruda, Mauro Maciel; Figueiredo, Fabiano Borges; Marcelino, Andreza Pain; Barbosa, José Ronaldo; Werneck, Guilherme Loureiro; Noronha, Elza Ferreira; Romero, Gustavo Adolfo Sierra

    2016-01-01

    In Brazil, human and canine visceral leishmaniasis (CVL) caused byLeishmania infantum has undergone urbanisation since 1980, constituting a public health problem, and serological tests are tools of choice for identifying infected dogs. Until recently, the Brazilian zoonoses control program recommended enzyme-linked immunosorbent assays (ELISA) and indirect immunofluorescence assays (IFA) as the screening and confirmatory methods, respectively, for the detection of canine infection. The purpose of this study was to estimate the accuracy of ELISA and IFA in parallel or serial combinations. The reference standard comprised the results of direct visualisation of parasites in histological sections, immunohistochemical test, or isolation of the parasite in culture. Samples from 98 cases and 1,327 noncases were included. Individually, both tests presented sensitivity of 91.8% and 90.8%, and specificity of 83.4 and 53.4%, for the ELISA and IFA, respectively. When tests were used in parallel combination, sensitivity attained 99.2%, while specificity dropped to 44.8%. When used in serial combination (ELISA followed by IFA), decreased sensitivity (83.3%) and increased specificity (92.5%) were observed. Serial testing approach improved specificity with moderate loss in sensitivity. This strategy could partially fulfill the needs of public health and dog owners for a more accurate diagnosis of CVL. PMID:26910354

  16. Sensitivity and specificity of parallel or serial serological testing for detection of canine Leishmania infection.

    PubMed

    Arruda, Mauro Maciel de; Figueiredo, Fabiano Borges; Marcelino, Andreza Pain; Barbosa, José Ronaldo; Werneck, Guilherme Loureiro; Noronha, Elza Ferreira; Romero, Gustavo Adolfo Sierra

    2016-03-01

    In Brazil, human and canine visceral leishmaniasis (CVL) caused by Leishmania infantum has undergone urbanisation since 1980, constituting a public health problem, and serological tests are tools of choice for identifying infected dogs. Until recently, the Brazilian zoonoses control program recommended enzyme-linked immunosorbent assays (ELISA) and indirect immunofluorescence assays (IFA) as the screening and confirmatory methods, respectively, for the detection of canine infection. The purpose of this study was to estimate the accuracy of ELISA and IFA in parallel or serial combinations. The reference standard comprised the results of direct visualisation of parasites in histological sections, immunohistochemical test, or isolation of the parasite in culture. Samples from 98 cases and 1,327 noncases were included. Individually, both tests presented sensitivity of 91.8% and 90.8%, and specificity of 83.4 and 53.4%, for the ELISA and IFA, respectively. When tests were used in parallel combination, sensitivity attained 99.2%, while specificity dropped to 44.8%. When used in serial combination (ELISA followed by IFA), decreased sensitivity (83.3%) and increased specificity (92.5%) were observed. Serial testing approach improved specificity with moderate loss in sensitivity. This strategy could partially fulfill the needs of public health and dog owners for a more accurate diagnosis of CVL. PMID:26910354

  17. METHOD AND APPARATUS FOR TESTING THE PRESENCE OF SPECIFIC ATOMIC ELEMENTS IN A SUBSTANCE

    DOEpatents

    Putman, J.L.

    1960-01-26

    Detection of specific atomic elements in a substance and particularly the applicability to well logging are discussed. The principal novelty resides in the determination of several of the auxiliary energy peaks in addition to the main energy peak of the gamma-ray energy spectrum of a substance and comparison of such peaks to the spectrum of the specific atomic element being tested for. thus resulting in identification of same. The invention facilitates the identification of specific elements even when in the presence of other elements having similar gamma energy spectra as to the main energy peaks.

  18. Sport-Specific Motor Fitness Tests in Water Polo: Reliability, Validity and Playing Position Differences

    PubMed Central

    Uljevic, Ognjen; Spasic, Miodrag; Sekulic, Damir

    2013-01-01

    Sport-specific motor fitness tests are not often examined in water polo. In this study we examined the reliability, factorial and discriminative validity of 10 water-polo-specific motor-fitness tests, namely: three tests of in-water jumps (thrusts), two characteristic swimming sprints (10 and 20 metres from the water start), three ball-throws (shoots), one test of passing precision (accuracy), and a test of the dynamometric force produced while using the eggbeater kick. The sample of subjects consisted of 54 young male water polo players (15 to 17 years of age; 1.86 ± 0.07 m, and 83.1 ± 9.9 kg). All tests were applied over three testing trials. Reliability analyses included Cronbach Alpha coefficients (CA), inter-item- correlations (IIR) and coefficients of the variation (CV), while an analysis of variance was used to define any systematic bias between the testing trials. All tests except the test of accuracy (precision) were found to be reliable (CA ranged from 0.83 to 0.97; IIR from 0.62 to 0.91; CV from 2% to 21%); with small and irregular biases between the testing trials. Factor analysis revealed that jumping capacities as well as throwing and sprinting capacities should be observed as a relatively independent latent dimensions among young water polo players. Discriminative validity of the applied tests is partially proven since the playing positions significantly (p < 0.05) differed in some of the applied tests, with the points being superior in their fitness capacities in comparison to their teammates. This study included players from one of the world’s best junior National leagues, and reported values could be used as fitness standards for such an age. Further studies are needed to examine the applicability of the proposed test procedures to older subjects and females. Key Points Here presented and validated sport specific water polo motor fitness tests are found to be reliable in the sample of young male water polo players. Factor analysis revealed

  19. Validity of critical frequency test for measuring table tennis aerobic endurance through specific protocol

    PubMed Central

    Zagatto, Alessandro M.; Papoti, Marcelo; Gobatto, Claudio A.

    2008-01-01

    The aim of this study was to validate critical frequency specific test (critf) for the estimation of the aerobic endurance in table tennis players. Methods: Eight male international-level table tennis players participated of this study. Specific tests were applied by using a mechanical ball thrower to control the intensity of the exercise. The critf was determined by applying three or four series of exercises to exhaustion (Tlim). The critf was evaluated by using lactate steady state test (90, 100, and 106 % of critf intensity). The other specific test was an incremental protocol used to determine the anaerobic threshold (AnTBI) and the onset of blood lactate accumulation (OBLA) using a ball thrower. Results: The critf (39.87 ± 3.31 balls·min-1) was not significantly different among AnTBI (48.11 ± 7.36 balls·min- 1) and OBLA3.5 (49.36 ± 12.04 balls·min-1) frequencies and it was correlated with AnTBI parameter (r = 0.78). At frequencies of the 90 and 100% of critf a dynamic equilibrium was verified in lactate concentration between the eighth and twentieth minutes. However, this dynamic equilibrium was not found at 106% intensity. Conclusion: The data indicate that in table tennis the critf model can be used for measuring the aerobic endurance. Key pointsIn table tennis is need the use of a specific protocol for evaluation of the aerobic endurance.The critical frequency test in table tennis seems to represent the intensity of maximal equilibrium of lactatemia.The critical frequency test can be used for measuring table tennis aerobic endurance through specific protocol. PMID:24149951

  20. 40 CFR Appendix A to Part 75 - Specifications and Test Procedures

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... require) performing a flow profile study following the procedures in 40 CFR part 60, appendix A, method, 1... 40 CFR part 60, appendix A, Test Method 1, section 11.5 may be used even if the flow measurement... section 8.1.1 of Performance Specification 2 in appendix B to part 60 of this chapter, install...

  1. Development of USES Specific Aptitude Test Battery for Ticket Agent (any ind.) 238.367-026.

    ERIC Educational Resources Information Center

    Utah State Dept. of Employment Security, Salt Lake City. Western Test Development Field Center.

    The United States Employment Service (USES) Specific Aptitude Test Battery (SATB) for Ticket Agent is evaluated from three points of view: (1) technical adequacy of the research; (2) fairness to minorities; and (3) usefulness of the battery to Employment Service staff and employers in selecting individuals for ticket agent positions. Research…

  2. Testing a Bilinear Domain-Specific Model of Acculturation and Enculturation across Generational Status

    ERIC Educational Resources Information Center

    Miller, Matthew J.

    2010-01-01

    This study attempted to replicate Miller's (2007) finding that a bilinear domain-specific model of Asian American acculturation demonstrated superior model fit when compared to unilinear and bilinear domain-generic models. Current confirmatory factor analytic tests of competing acculturation models in a cross-validation sample of 306 participants…

  3. Development of USES Specific Aptitude Test Battery for Refinery Operator (petrol. refin.) 549.260-010.

    ERIC Educational Resources Information Center

    1982

    The United States Employment Service (USES) Specific Aptitude Test Battery (SATB) for Refinery Operator is evaluated from three points of view: (1) technical adequacy of the research; (2) fairness to minorities; and (3) usefulness of the battery to Employment Service staff and employers in selecting individuals for training in refinery operator…

  4. 40 CFR 86.1375-2007 - Equipment specifications for field testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Equipment specifications for field testing. 86.1375-2007 Section 86.1375-2007 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Emission Regulations for New...

  5. 49 CFR 180.509 - Requirements for inspection and test of specification tank cars.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Requirements for inspection and test of specification tank cars. 180.509 Section 180.509 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CONTINUING QUALIFICATION...

  6. Interactions among Domain-Specific Expectancies, Values, and Gender: Predictors of Test Anxiety during Early Adolescence

    ERIC Educational Resources Information Center

    Selkirk, Laura C.; Bouchey, Heather A.; Eccles, Jacquelynne S.

    2011-01-01

    This research focuses on the interaction between students' domain-specific expectancies and values as a predictor of test anxiety. A subsample of adolescents from the MSALT dataset are used in the current study; students complete measures during the spring of sixth grade and again during the spring of seventh grade. Overall, findings provide…

  7. California Verbal Learning Test Indicators of Malingered Neurocognitive Dysfunction: Sensitivity and Specificity in Traumatic Brain Injury

    ERIC Educational Resources Information Center

    Curtis, Kelly L.; Greve, Kevin W.; Bianchini, Kevin J.; Brennan, Adrianne

    2006-01-01

    The present study used well-defined traumatic brain injury (TBI) and mixed neurological (other than TBI) and psychiatric samples to examine the specificity and sensitivity to Malingered Neurocognitive Dysfunction (MND) of four individual California Verbal Learning Test (CVLT) variables and eight composite CVLT malingering indicators. Participants…

  8. 21 CFR 866.5530 - Immunoglobulin G (Fc fragment specific) immunological test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Immunoglobulin G (Fc fragment specific) immunological test system. 866.5530 Section 866.5530 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... abnormalities, e.g., gamma heavy chain disease. (b) Classification. Class I (general controls). The device...

  9. 21 CFR 866.5530 - Immunoglobulin G (Fc fragment specific) immunological test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Immunoglobulin G (Fc fragment specific) immunological test system. 866.5530 Section 866.5530 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... abnormalities, e.g., gamma heavy chain disease. (b) Classification. Class I (general controls). The device...

  10. 21 CFR 866.5540 - Immunoglobulin G (Fd fragment specific) immunological test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Immunoglobulin G (Fd fragment specific) immunological test system. 866.5540 Section 866.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... fragment) of the heavy chain (a subunit) of the immunoglobulin antibody molecule in serum. Measurement...

  11. 21 CFR 866.5530 - Immunoglobulin G (Fc fragment specific) immunological test system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Immunoglobulin G (Fc fragment specific) immunological test system. 866.5530 Section 866.5530 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... abnormalities, e.g., gamma heavy chain disease. (b) Classification. Class I (general controls). The device...

  12. 21 CFR 866.5540 - Immunoglobulin G (Fd fragment specific) immunological test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Immunoglobulin G (Fd fragment specific) immunological test system. 866.5540 Section 866.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... fragment) of the heavy chain (a subunit) of the immunoglobulin antibody molecule in serum. Measurement...

  13. 21 CFR 866.5540 - Immunoglobulin G (Fd fragment specific) immunological test system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Immunoglobulin G (Fd fragment specific) immunological test system. 866.5540 Section 866.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... fragment) of the heavy chain (a subunit) of the immunoglobulin antibody molecule in serum. Measurement...

  14. 21 CFR 866.5530 - Immunoglobulin G (Fc fragment specific) immunological test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Immunoglobulin G (Fc fragment specific) immunological test system. 866.5530 Section 866.5530 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... abnormalities, e.g., gamma heavy chain disease. (b) Classification. Class I (general controls). The device...

  15. 21 CFR 866.5540 - Immunoglobulin G (Fd fragment specific) immunological test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Immunoglobulin G (Fd fragment specific) immunological test system. 866.5540 Section 866.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... fragment) of the heavy chain (a subunit) of the immunoglobulin antibody molecule in serum. Measurement...

  16. 21 CFR 866.5530 - Immunoglobulin G (Fc fragment specific) immunological test system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Immunoglobulin G (Fc fragment specific) immunological test system. 866.5530 Section 866.5530 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... abnormalities, e.g., gamma heavy chain disease. (b) Classification. Class I (general controls). The device...

  17. 21 CFR 866.5540 - Immunoglobulin G (Fd fragment specific) immunological test system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Immunoglobulin G (Fd fragment specific) immunological test system. 866.5540 Section 866.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... fragment) of the heavy chain (a subunit) of the immunoglobulin antibody molecule in serum. Measurement...

  18. Using a Table of Specifications to Improve Teacher-Constructed Traditional Tests: An Experimental Design

    ERIC Educational Resources Information Center

    DiDonato-Barnes, Nicole; Fives, Helenrose; Krause, Emily S.

    2014-01-01

    We investigated if instruction on a Table of Specifications (TOS) would influence the quality of classroom test construction. Results should prove informative for educational researchers, teacher educators, and practising teachers interested in evidenced-based strategies that may improve assessment-related practices. Fifty-three college…

  19. 75 FR 20832 - Environmental Management Site-Specific Advisory Board, Nevada Test Site

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada Test Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal...

  20. 40 CFR 53.51 - Demonstration of compliance with design specifications and manufacturing and test requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Demonstration of compliance with design specifications and manufacturing and test requirements. 53.51 Section 53.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) AMBIENT AIR MONITORING REFERENCE AND EQUIVALENT METHODS Procedures for...

  1. Awareness and use of the prostate-specific antigen test among African-American men.

    PubMed Central

    Ross, Louie E.; Uhler, Robert J.; Williams, Kymber N.

    2005-01-01

    Although African-American men have a greater burden of prostate cancer than whites and other racial and ethnic groups, few studies on the burden of prostate cancer have focused on African Americans specifically. We used a sample of African-American men (N = 736) who participated in the 2000 National Health Interview Survey to explore their awareness of the prostate-specific antigen (PSA) test. Among African-American men aged > or = 45 with no history of prostate cancer, 63% had heard of the PSA test and 48% had been tested. Bivariate analyses showed significant associations between sociodemographic, family composition, health status and perceived risk with having heard of the PSA test and having been tested. The multivariate model showed significant associations between having heard of the PSA test and age, level of education, living in an MSA, and having private or military health insurance. For ever being tested, the multivariate model showed significant associations for age, private or military health insurance, being in fair or poor health, and having a family history of prostate cancer. Some of the correlates, such as age, increased levels of education and being married, were consistent with previous studies, but other correlates, such as metropolitan statistical area, health status and perceived risk, differed from previous studies. PMID:16080666

  2. Comparison of the basophil activation test versus the nasal provocation test in establishing eligibility for specific immunotherapy.

    PubMed

    Leśniak, Małgorzata; Dyga, Wojciech; Rusinek, Barbara; Mazur, Marcel; Czarnobilska, Ewa

    2016-08-25

    INTRODUCTION    Allergic rhinitis (AR) is the most common atopic disease. Specific immunotherapy (SIT) is the only effective treatment method for AR. In uncertain diagnostic cases, before establishing eligibility for SIT, nasal provocation tests (NPTs) should be performed. However, there are numerous contraindications to performing NPTs, and there is ongoing search for an alternative in vitro method. OBJECTIVES    The aim of the study was to determine whether a specific in vitro provocation, that is, the basophil activation test (BAT), may replace a specific in vivo provocation, that is, the NPT, in establishing patient's eligibility for SIT. PATIENTS AND METHODS    The study included 30 patients with AR caused by allergy to house dust mite or birch pollen, referred for SIT. The assessment of basophil activation by measuring CD63 antigen expression was performed using the Flow2 CAST test. Basophils were stimulated with allergen preparation (concentrations of 5000, 500, and 50 standardized biological units) used in NPTs. BAT results were expressed as stimulation index (SI) and basophil reactivity (BR). RESULTS    Allergen concentrations of 500 and 50 SBU proved to be appropriate for basophil stimulation. Median SI and BR were higher for positive NPT results than for negative NPT results (P <0.001). Sensitivity for SI and BR was in the range from 83% to 100%; specificity, from 78% to 89%; positive predictive value, from 75% to 87%; and negative predictive value, from 89% to 100%. We observed a high correlation of the analyzed parameters for the allergen concentrations of 500 and 50 SBU (range, 0.58-0.74; P <0.05). CONCLUSIONS    If there are contraindications to performing the NPT, BAT may be regarded as an alternative in establishing patients' eligibility for SIT. The optimal concentrations of allergen preparations are 500 and 50 SBU. Both SI and BR are good indicators of basophil activation. PMID:27578221

  3. Practice Effect and Normative Data of an HIV-specific Neuropsychological Testing Battery among Healthy Thais

    PubMed Central

    Sithinamsuwan, Pasiri; Hutchings, Nicholas; Ananworanich, Jintanat; Wendelken, Lauren; Saengtawan, Putthachard; Paul, Robert; Chomchey, Nitiya; Fletcher, James LK; Chalermchai, Thep; Valcour, Victor

    2015-01-01

    Objective A longitudinal cohort study was conducted in Bangkok, Thailand between 2008 and 2013 in order to determine the practice effect of serial neuropsychological testing and establish normative data among normal (HIV-uninfected) Thai volunteers. Material and Method The authors enrolled 511 cognitively healthy individuals (HIV-uninfected, no drug abuse or other previous/current neurological or psychological conditions) to assess baseline performance on a HIV-specific neuropsychological testing battery. Ninety-nine subjects were re-assessed at 6 and 12 months to evaluate practice effects. Results The mean age of the 99 subjects completing longitudinal visits was 49.2 years and 53 were male. The authors identified improved mean raw scores on most neuropsychological tests with repeated measurements; however, only change in WHO Auditory Verbal Learning Test (AVLT) scores (learning, attention, immediate and delayed recall tasks) met statistical significance, with larger differences seen between baseline and 6-month compared to 6 and 12 months follow-up. Older age correlated with poorer baseline raw score, and was a predictor of worse performance at 6 months and 12 months on several tasks. Level of education was associated with practice effects on several tests. No similar effects were observed with gender. Conclusion The authors identified improved performance after repeated measurements revealing a significant practice effect on an HIV-specific neuropsychological testing battery employed in Bangkok, Thailand. Main predictors were age and educational attainment. PMID:25518198

  4. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  5. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  6. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  7. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  8. 16 CFR 1000.2 - Laws administered.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Laws administered. 1000.2 Section 1000.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.2 Laws administered. The Commission administers five acts: (a) The Consumer Product Safety Act...

  9. A novel agglutination test for antigen-specific detection of platelet antibodies.

    PubMed

    Meyer, Oliver; Agaylan, Ashraf; Borchert, Hans-Hubert; Aslan, Tunay; Bombard, Stéphane; Kiesewetter, Holger; Salama, Abdulgabar

    2006-10-15

    A simple and rapid antigen-specific assay for the identification antibodies to platelets is lacking, yet. Red-dyed polystyrene microbeads were coated with monoclonal antibodies to various platelet glycoprotein complexes, and used for the detection of platelet autoantibodies and alloantibodies. The results were largely identical with those obtained by monoclonal antibody-specific immobilization of platelet antigen assay (MAIPA). The new test is reliable yet less complex and time-consuming than the currently available assays, and it can be implemented in any routine laboratory. PMID:16933262

  10. Thyroid Function Testing in Pregnancy and Thyroid Disease: Trimester-specific Reference Intervals

    PubMed Central

    Soldin, Offie P.

    2013-01-01

    During pregnancy the thyroid is hyperstimulated, resulting in changes in thyroid hormone concentrations. Accurate assessment of thyroid function during pregnancy is critical, for both the initiation of thyroid hormone therapy, and for the adjustment of thyroid hormone dose in those already receiving thyroid hormone. Trimester-specific intervals are especially important during pregnancy when thyroid insufficiency may be associated with adverse obstetric outcome and fetal neurodevelopmental deficits. Gestational age-specific reference intervals are now available for thyroid function tests. Knowing the expected normal changes in hormone concentrations throughout pregnancy allows individualized supplementation when necessary. PMID:16418685

  11. Specification, procurement and testing of passivated microwave semiconductor chips for space applications

    NASA Astrophysics Data System (ADS)

    Zahn, Reinhold L.; Schumacher, Petra K.

    1991-03-01

    Employing passivated microwave semiconductor chip devices in space systems is a challenge for both applications engineeering and parts procurement. The use of chip devices results in miniature circuits as well as optimum circuit performance. The signal to noise ratio and power consumption are improved. With the demand for higher frequencies the dimensions become smaller with associated handling difficulties and problems with regard to chip assembly. The status of procurement specifications applicable to microwave semiconductor chip devices is reviewed, using the ESA/PSS-01-608. Key items for useful procurement specifications are highlighted. Results of testing and handling investigations on low noise microwave Field Effect Transistors (MESFET) chips are described.

  12. Sensitivity and specificity of rapid influenza testing of children in a community setting 1

    PubMed Central

    Stebbins, Samuel; Stark, James H.; Prasad, Ramakrishna; Thompson, William W.; Mitruka, Kiren; Rinaldo, Charles; Vukotich, Charles J.; Cummings, Derek A. T.

    2010-01-01

    Please cite this paper as: Stebbins et al. (2011) Sensitivity and specificity of rapid influenza testing of children in a community setting. Influenza and Other Respiratory Viruses 5(2), 104–109. Introduction  Rapid influenza testing (RFT) allows for a rapid point‐of‐care diagnosis of influenza. The Quidel QuickVue® Influenza A+B test (QuickVue) has a reported manufacturer’s sensitivity and specificity of 73% and 96%, respectively, with nasal swabs. However, investigators have shown sensitivities ranging from 22% to 77% in community settings. Methods  The QuickVue rapid influenza test was evaluated in a population of elementary (K‐5) school children, using testing in the home, as part of the Pittsburgh Influenza Prevention Project during the 2007–2008 influenza season. The QuickVue test was performed with nasal swab in full accordance with package instructions and compared with the results of nasal swab semi‐quantitative RT‐PCR. Results  Sensitivity of the QuickVue was found to be 27% in this sample. There was no statistically valid correlation between the semi‐quantitative PCR result and the QuickVue result. Conclusions  This study is consistent with the low sensitivity of the QuickVue test also reported by others. Viral load, technique, and the use of nasal swabs were examined as contributing factors but were not found to be explanations for this result. Community testing includes patients who are on the lower spectrum of illness which would not be the case in hospital or clinic samples. This suggests that RFT is less sensitive for patients at the lower spectrum of illness, with less severe disease. PMID:21306573

  13. Sensitivity and specificity of the functional hallux limitus test to predict foot function.

    PubMed

    Payne, Craig; Chuter, Vivienne; Miller, Kathryn

    2002-05-01

    Functional hallux limitus is an underrecognized entity that generally does not produce symptoms but can result in a variety of compensatory mechanisms that can produce symptoms. Clinically, hallux limitus can be determined by assessing the range of motion available at the first metatarsophalangeal joint while the first ray is prevented from plantarflexing. The aim of this study was to determine the sensitivity and specificity of this clinical test to predict abnormal excessive midtarsal joint function during gait. A total of 86 feet were examined for functional hallux limitus and abnormal pronation of the midtarsal joint during late midstance. The test had a sensitivity of 0.72 and a specificity of 0.66, suggesting that clinicians should consider functional hallux limitus when there is late midstance pronation of the midtarsal joint during gait. PMID:12015407

  14. Treponema-Specific Tests for Serodiagnosis of Syphilis: Comparative Evaluation of Seven Assays▿

    PubMed Central

    Binnicker, M. J.; Jespersen, D. J.; Rollins, L. O.

    2011-01-01

    The diagnosis of syphilis is challenging and often relies on serologic tests to detect treponemal or nontreponemal antibodies. Recently, the Centers for Disease Control and Prevention and the Association of Public Health Laboratories proposed an update to the syphilis serology testing algorithm, in which serum samples are first tested using a treponema-specific test and positive samples are analyzed with a nontreponemal assay. The goal of this study was to compare the performance of seven treponemal assays (BioPlex 2200 syphilis IgG [Bio-Rad, Hercules, CA], fluorescent treponemal antibody [FTA] assay [Zeus Scientific, Raritan, NJ], Treponema pallidum particle agglutination [TP-PA; Fujirebio Diagnostics, Malvern, PA], Trep-Sure enzyme immunoassay [EIA; Phoenix Biotech, Oakville, Ontario, Canada], Trep-Chek EIA [Phoenix Biotech], Trep-ID EIA [Phoenix Biotech], and Treponema ViraBlot IgG [Viramed Biotech AG, Planegg, Germany]) using serum samples (n = 303) submitted to our reference laboratory. In addition to testing with these 7 assays, all samples were tested by a rapid plasma reagin (RPR) assay and a treponemal IgM Western blot assay (Viramed ViraBlot). Compared to the FTA assay as the gold standard, the evaluated treponemal tests demonstrated comparable levels of performance, with percent agreement ranging from 95.4% (95% confidence interval, 92.3 to 97.3) for the Trep-Sure EIA to 98.4% (96.1 to 99.4) for the Trep-ID EIA. Compared to a “consensus of the test panel” (defined as at least 4 of 7 treponemal tests being in agreement), the percent agreement ranged from 95.7% (92.7 to 97.5) for Trep-Sure to 99.3% (97.5 to 99.9) for Trep-ID. These data may assist clinical laboratories that are considering implementing a treponemal test for screening or confirmatory purposes. PMID:21346050

  15. Retesting The Validity Of A Specific Field Test For Judo Training

    PubMed Central

    Santos, Luis; González, Vicente; Iscar, Marta; Brime, Juan I.; Fernández-Río, Javier; Rodríguez, Blanca; Montoliu, Mª Ángeles

    2011-01-01

    The main goal of this research project was to retest the validity of a specifically designed judo field test (Santos Test) in a different group of judokas. Eight (n=8) national-level male judokas underwent laboratory and field testing. The mean data (mean +/− SD) obtained in the laboratory tests was: HRmax: 200 ± 4.0 beats × min−1, VO2 max: 52.8 ± 7.9 ± ml × kg−1 × min−1, lactate max: 12 ± 2.5 mmol × l−1, HR at the anaerobic threshold: 174.2 ± 9.4 beats × min−1, percentage of maximum heart rate at which the anaerobic threshold appears: 87 ± 3.6 %, lactate threshold: 4.0 ± 0.2 mmol × l−1, and RPE: 17.2 ± 1.0. The mean data obtained in the field test (Santos) was: HRmax: 201.3 ± 4.1 beats × min−1, VO2 max: 55.6 ± 5.8 ml × kg−1 × min−1, lactate max: 15.6 ± 2.8 mmol × l−1, HR at the anaerobic threshold: 173.2 ± 4.3 beats × min−1, percentage of maximum heart rate at which the anaerobic threshold appears: 86 ± 2.5 %, lactate threshold: 4.0 ± 0.2 mmol × l−1, and RPE: 16.7 ± 1.0. There were no significant differences between the data obtained on both tests in any of the parameters, except for maximum lactate concentration. Therefore, the Santos test can be considered a valid tool specific for judo training. PMID:23486994

  16. Clinical relevance of multiple antibody specificity testing in anti-phospholipid syndrome and recurrent pregnancy loss

    PubMed Central

    Tebo, A E; Jaskowski, T D; Hill, H R; Branch, D W

    2008-01-01

    We wanted to evaluate whether testing for anti-phosholipid antibodies other than anti-cardiolipin (aCL) and anti-beta-2 glycoprotein I (aβ2GPI) immunoglobulin (Ig)G and IgM identifies patients with recurrent pregnancy loss (RPL) who may be positive for anti-phospholipid syndrome (APS). In a cross-sectional study comprising 62 patients with APS, 66 women with RPL, 50 healthy blood donors and 24 women with a history of successful pregnancies, we tested IgM and IgG antibodies to phosphatidic acid, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl glycerol, phosphatidyl inositol and phosphatidyl serine with and without beta-2 glycoprotein I (β2GPI) from a single manufacturer as well as aCL and aβ2GPI antibodies. Diagnostic accuracies of individual and combined anti-phospholipid (aPL) assays were assessed by computing sensitivities, specificities, positive predictive values and negative predictive values together with their 95% confidence intervals. There was a general trend for increased sensitivities in the presence of β2GPI co-factor with significant effect for certain specificities. The overall combined sensitivity of the non-recommended aPL assays was not significantly higher than that of the aCL and aB2GPI tests. Multiple aPL specificities in RPL group is not significantly different from controls and therefore of no clinical significance. PMID:18826497

  17. Clinical relevance of multiple antibody specificity testing in anti-phospholipid syndrome and recurrent pregnancy loss.

    PubMed

    Tebo, A E; Jaskowski, T D; Hill, H R; Branch, D W

    2008-12-01

    We wanted to evaluate whether testing for anti-phosholipid antibodies other than anti-cardiolipin (aCL) and anti-beta-2 glycoprotein I (abeta2GPI) immunoglobulin (Ig)G and IgM identifies patients with recurrent pregnancy loss (RPL) who may be positive for anti-phospholipid syndrome (APS). In a cross-sectional study comprising 62 patients with APS, 66 women with RPL, 50 healthy blood donors and 24 women with a history of successful pregnancies, we tested IgM and IgG antibodies to phosphatidic acid, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl glycerol, phosphatidyl inositol and phosphatidyl serine with and without beta-2 glycoprotein I (beta2GPI) from a single manufacturer as well as aCL and abeta2GPI antibodies. Diagnostic accuracies of individual and combined anti-phospholipid (aPL) assays were assessed by computing sensitivities, specificities, positive predictive values and negative predictive values together with their 95% confidence intervals. There was a general trend for increased sensitivities in the presence of beta2GPI co-factor with significant effect for certain specificities. The overall combined sensitivity of the non-recommended aPL assays was not significantly higher than that of the aCL and aB2GPI tests. Multiple aPL specificities in RPL group is not significantly different from controls and therefore of no clinical significance. PMID:18826497

  18. Engineering and specifications for HVAC systems relating to testing and balancing

    SciTech Connect

    Rose, R.

    1999-07-01

    Over the past several years, there have been numerous performance problems relating to building mechanical systems. In evaluating the causes for this poor performance, there seemed to be a lack of commitment, lack of enforcement of specified items, and a lack of understanding of the design intent by the key participants. Communication between the architect, engineer, suppliers, and the contractors is essential. If any one of the participating members does not follow through with his responsibilities, the building's overall performance will suffer. The intent of this paper is to point out key areas that generally cause poor system performance and to expound on specific areas of ANSI/ASHRAE Standard 111-1988, Practices for Measuring, Testing, Adjusting, and Balancing of Building Heating, Ventilation, Air-Conditioning, and Refrigeration Systems (ASHRAE 1998), and NEBB 1991, Procedural Standards for Testing, Adjusting, Balancing of Environmental Systems (NEBB 1991), thus creating a fluent, positive mechanical design specification that fills these gaps. This paper will also address the basic problems and concerns test and balance contractors face every day and, by emphasizing certain enforceable language in the specification, allow the system to be balanced properly and improve the overall building performance.

  19. Acoustic specifications for the design of jet engine test facilities on an airbase

    SciTech Connect

    Strumpf, F.M.

    1982-01-01

    The use of engine run up test arrangements was common in Israeli air-bases since the forties, when engines for the Mustang, Mosquito, Harward and other propellor powered planes were used. The era of jet engine propulsion boosted the noise levels, and the use of fighters with afterburners in the new engines of the 80's brought it up to unbearable levels. Thus, the growth of the Israeli Air Force demanded the use of efficient noise suppression devices. These were divided into engine run-up noise suppressors, and aircraft noise suppessors (Hush Houses). For both of the bove ground arrangements, acoustic specifications had to be given. They were, as well as design goals for the manufacturers, also needed to restrict noise levels on the air-base as well as its surroundings. The acoustic specifications discussed are based on measured data, and permitted noise levels in the homes on the base being as far as 2500 meters from the engine exhaust silencer. For the special air-base discussed, various criteria were tested, including US Military Specifications, none of which were acceptable, and a special specification was therefore prepared.

  20. Developing a Non-Language Related Span Test for the Use in Language-Specific and Cross-Language Studies

    ERIC Educational Resources Information Center

    Shahnazari-Dorcheh, Mohammadtaghi; Roshan, Saeed

    2012-01-01

    Due to the lack of span test for the use in language-specific and cross-language studies, this study provides L1 and L2 researchers with a reliable language-independent span test (math span test) for the measurement of working memory capacity. It also describes the development, validation, and scoring method of this test. This test included 70…

  1. Hypothetical accident conditions, free drop and thermal tests: Specification 6M

    SciTech Connect

    Blankenship, R.W.

    1980-05-01

    The 30 gallon Specification 6M shipping container with rolled-top food pack cans as inner containers is evaluated under conditions required by 10 CFR 71.42. One kilogram of depleted uranium as UO/sub 2/ was packaged in each of the inner containers. After completion of a free drop test and a simulated thermal test, the maximum observed leakage of UO/sub 2/ for the following week was 3.2 ..mu..g. This leakage is well below the allowable leakage per week for most plutonium isotopic mixtures. Using the examples provided, any plutonium isotopic mixture can be easily compared with the allowable leakage per week. Test conditions and results are reported.

  2. ‘It's a maybe test’: men's experiences of prostate specific antigen testing in primary care

    PubMed Central

    Evans, Rhodri; Edwards, Adrian GK; Elwyn, Glyn; Watson, Eila; Grol, Richard; Brett, Jo; Austoker, Joan

    2007-01-01

    Background Prostate specific antigen (PSA) testing in primary care is an important and contentious issue. Due to concerns about the test and the value of early detection, countries such as the UK advocate ‘informed choice’ instead of population screening. It is not known whether this policy is actually adhered to in primary care. Furthermore, little is known of the experiences of men who face this decision. Aim To explore the experiences, understanding, and views of men who considered or undertook PSA testing in UK primary care. Design of study Qualitative interview-based study. Setting Primary care, Wales, UK. Method Semi-structured one-to-one interviews were conducted with 28 men, representing a range of clinical outcomes. Transcripts were coded and subjected to thematic analysis. Results Three themes were identified: the decision-making context, the locus of decision making, and uncertainty related to the PSA test. Conclusion The decision to undertake PSA testing was affected by both social and media factors and it did not appear to be a patient-led decision. The decision created considerable uncertainty for men and this uncertainty persisted after the test, even if the result was normal. Raised PSA led to further investigations and this exacerbated the uncertainty. Anxiety and regret were consequences of this uncertainty. PMID:17394734

  3. Status and specifications of a Project X front-end accelerator test facility at Fermilab

    SciTech Connect

    Steimel, J.; Webber, R.; Madrak, R.; Wildman, D.; Pasquinelli, R.; Evans-Peoples, E.; /Fermilab

    2011-03-01

    This paper describes the construction and operational status of an accelerator test facility for Project X. The purpose of this facility is for Project X component development activities that benefit from beam tests and any development activities that require 325 MHz or 650 MHz RF power. It presently includes an H- beam line, a 325 MHz superconducting cavity test facility, a 325 MHz (pulsed) RF power source, and a 650 MHz (CW) RF power source. The paper also discusses some specific Project X components that will be tested in the facility. Fermilab's future involves new facilities to advance the intensity frontier. In the early 2000's, the vision was a pulsed, superconducting, 8 GeV linac capable of injecting directly into the Fermilab Main Injector. Prototyping the front-end of such a machine started in 2005 under a program named the High Intensity Neutrino Source (HINS). While the HINS test facility was being constructed, the concept of a new, more versatile accelerator for the intensity frontier, now called Project X, was forming. This accelerator comprises a 3 GeV CW superconducting linac with an associated experimental program, followed by a pulsed 8 GeV superconducting linac to feed the Main Injector synchrotron. The CW Project X design is now the model for Fermilab's future intensity frontier program. Although CW operation is incompatible with the original HINS front-end design, the installation remains useful for development and testing many Project X components.

  4. Use of Specific IgE and Skin Prick Test to Determine Clinical Reaction Severity.

    PubMed

    Ta, Von; Weldon, Brittany; Yu, Grace; Humblet, Olivier; Neale-May, Susan; Nadeau, Kari

    2011-01-01

    AIMS: To determine whether specific IgE and skin prick test correlate better in predicting reaction severity during a double-blinded placebo controlled food challenge (DBPCFC) for egg, milk, and multiple tree nut allergens. STUDY DESIGN: Prospective study. PLACE AND DURATION OF STUDY: Department of Pediatrics, Stanford University School of Medicine, August 2009 and ongoing. METHODOLOGY: We examined the reaction severity of twenty-four subjects to nine possible food allergens: milk, egg, almond, cashew, hazelnut, peanut, sesame, pecan and walnut. Specific IgE and SPT were performed before each DBPCFC. DBPCFC results were classified into mild (1), moderate (2), or severe (3) reactions using a modified Bock's criteria. RESULTS: Twenty four subjects underwent a total of 80 DBPCFC. Eighty percent of all DBPCFCs resulted in a positive reaction. A majority, 71%, were classified as mild. No reactions occurred with a SPT of zero mm while three reactions occurred with a negative specific IgE. All reactions were reversible with medication. CONCLUSION: These data suggest that SPT and specific IgE levels are not associated with reaction severity (p<0.64 and 0.27, respectively). We also found that combining specific IgE and SPT improved specificity but did not help to achieve clinically useful sensitivity. For instance, an SPT > 5mm had a sensitivity of 91% and specificity of 50%. Combining SPT > 5mm and IgE > 7 resulted in a reduced sensitivity of 64%. Unexpectedly, a history of anaphylaxis 70% (n=17) was not predictive of anaphylaxis on challenge 4% (n=2). PMID:22993721

  5. CPV-specific test procedures for evaluating on-grid inverters

    NASA Astrophysics Data System (ADS)

    Domínguez, César; Voarino, Philippe; Lazpita, Begoña; Bier, Anthony; Besson, Pierre; Baudrit, Mathieu

    2014-09-01

    A new protocol for testing on-grid inverters accounting for the operating conditions specific to CPV arrays is introduced. First, a CPV-specific weighted average for providing the static conversion efficiency according to typical frequency distributions of CPV yield throughout the year. Then, a set of representative scenarios for analyzing the dynamic MPPT efficiency of the inverter: slow ramp (clear sky), fast cloud passage, self-shading between arrays (typical of sunrise and sunset) and a wavering current response typical of imperfect tracking. The procedures have been applied to two different string-size inverters at the CEA inverter test bench, which have revealed strong differences in their dynamic MPPT efficiency. The CPV-specific weighted average proposed was found to provide lower performance figures than the classical European and CEC efficiencies for the two studied inverters. This protocol provides important information for CPV plant dimensioning and equipment selection, as the differences in performance revealed can result in significant deviation on the final energy yield.

  6. Sensitivity, specificity and predictive values of immunochromatographic strip test in diagnosis of childhood kala-azar.

    PubMed

    Rouf, M A; Rahman, M E; Islam, M N; Islam, M N; Ferdous, N N; Hossain, M A

    2009-01-01

    In Bangladesh, the total population at risk for kala-azar exceeds 20 million (18%) living in 88 Thana (19%) of 27 districts (42%). A confirmatory diagnosis of visceral leishmaniasis (kala-azar) is done by demonstration of the parasite (LD body) in organ aspirates or tissue biopsy sample, an invasive procedure with relatively low sensitivity. To assess the diagnostic usefulness of ICT for antibody against the leishmanial antigen rK39 & its feasibility for use under field conditions (rural areas). An experimental study conducted during January, 2003 to July, 2003 in pediatrics department of MMCH including 60 confirmedly diagnosed KA cases & 60 controls having diseases other than KA. One drop of peripheral blood is applied to the nitrocellulose strip & 3 drops of test buffer is added to the dried blood. Observing 2 visible bands indicates presence of IgG anti-K39. The rK39 strip test was positive in 57 out of 60 confirmed KA case diagnosed by LD body demonstration in splenic or bone marrow aspirate. The estimated sensitivity was 95%. One control diagnosed as other than KA had positive strip test but negative aspirate smear. The estimated specificity of the strip test was 98.3%. The predictive value of a positive result is 98.3% & that of a negative result is 93.5%. rK39 strip test is highly sensitive & specific in our situation & it can be used as a simple & the best method for diagnosis of KA in rural areas. PMID:19377416

  7. Factors affecting sensitivity and specificity of a diagnostic test: the exercise thallium scintigram

    SciTech Connect

    Detrano, R.; Janosi, A.; Lyons, K.P.; Marcondes, G.; Abbassi, N.; Froelicher, V.F.

    1988-04-01

    Technical and methodological factors might affect the reported accuracies of diagnostic tests. To assess their influence on the accuracy of exercise thallium scintigraphy, the medical literature (1977 to 1986) was non-selectively searched and meta-analysis was applied to the 56 publications thus retrieved. These were analyzed for year of publication, sex and mean age of patients, percentage of patients with angina pectoris, percentage of patients with prior myocardial infarction, percentage of patients taking beta-blocking medications, and for angiographic referral (workup) bias, blinding of tests, and technical factors. The percentage of patients with myocardial infarction had the highest correlation with sensitivity (0.45, p = 0.0007). Only the inclusion of subjects with prior infarction and the percentage of men in the study group were independently and significantly (p less than 0.05) related to test sensitivity. Both the presence of workup bias and publication year adversely affected specificity (p less than 0.05). Of these two factors, publication year had the strongest association by stepwise linear regression. This analysis suggests that the reported sensitivity of thallium scintigraphy is higher and the specificity lower than that expected in clinical practice because of the presence of workup bias and the inappropriate inclusion of post-infarct patients.

  8. Development of a Specific Latex Agglutination Test to Detect Antibodies of Enterovirus 71.

    PubMed

    Qin, Bo; Zhang, Jianhua; Xie, Wenhao; Liu, Xuehong; He, Tingting; Chen, Jinkun; Dong, Xuejun

    2015-10-01

    A latex agglutination test (LAT) was developed for the rapid detection of antibodies against the VP1 or VP1 proteins of Enterovirus 71 (EV71). The proteins of interest including prokaryotically expressed VP1 and two strains of anti-VP1 monoclonal antibody (McAb) against EV71 were covalently linked to carboxylated latex using ethyl-dimethyl-amino-propyl carbodiimide (EDC) to prepare sensitized latex beads. LAT was evaluated by an enzyme-linked immunosorbent assay (ELISA) as a reference test. The VP1-LAT showed a sensitivity of 87.0%, specificity of 88.9%, and an agreement ratio of 90.0% in detecting VP1 in 100 serum samples from experimentally infected mice, whereas these values were 86.8, 96.7, and 93.3%, respectively, for 608 clinical human serum samples. The VP1-LAT has advantages over other assays in terms of low cost, rapidity, chemical stability, high sensitivity, repeatability, and specificity. The LAT established in the present study is a rapid and simple test suitable for field monitoring of antibodies against VP1-EV71. PMID:26363276

  9. Development and testing of biosensors that quantitatively and specifically detect organic contaminants

    SciTech Connect

    Jackson, P.; Keim, P.; Kuske, C.; Willardson, B.

    1996-07-01

    This is the final report of a two-year Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The project sought to develop a more sensitive and less expensive method of detecting organic contaminants. Assaying complex environmental samples for organic contaminant content is costly and labor intensive. This often limits extensive testing. Sensitive microbial biosensors that detect specific organic contaminants in complex waste mixtures without prior separation from other waste components have been developed. Some soil microbes degrade organic compounds that contaminate the environment. These bacteria sense minute quantities of particular organic compounds then respond by activating genes encoding enzymes that degrade these molecules. Genetic manipulation of these gene regulatory processes has been employed to develop unique biosensors that detect specific organic compounds using standard biochemical assays. Such biosensors allow rapid, sensitive testing of environmental samples for selected organic contaminants. The cost of biosensor assays is at least 100-fold less than present methods, allowing more rapid and extensive testing and site characterization.

  10. Rabies Group-Specific Ribonucleoprotein Antigen and a Test System for Grouping and Typing of Rhabdoviruses

    PubMed Central

    Schneider, L. G.; Dietzschold, B.; Dierks, R. E.; Matthaeus, W.; Enzmann, P.-J.; Strohmaier, K.

    1973-01-01

    Cell-associated ribonucleoprotein (RNP) was isolated from BHK-21 cells infected with several strains of rabies and rabies-related viruses. The RNP-antigen from rabies and related viruses induced the formation of complement-fixing, precipitating, and immunofluorescent antibodies, and proved to be the group-specific antigen common to all rabies viruses. Antigens of the envelope which induce virus-neutralizing antibodies are apparently determinative for the serotype of a virus as evidenced by two-way neutralization tests. A combination of these methods seems to be a useful approach to the serological grouping and typing of rhabdoviruses. Images PMID:4196634

  11. 40 CFR Appendix E to Part 52 - Performance Specifications and, Specification Test Procedures for Monitoring Systems for Effluent...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....7Reference method. Method 2 as delineated in 40 CFR Part 60. 4. Measurement system performance specifications... to Part 52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... corrective maintenance, repair, replacement or adjustment during the 168-hour performance and...

  12. Repeated significance tests of linear combinations of sensitivity and specificity of a diagnostic biomarker.

    PubMed

    Wu, Mixia; Shu, Yu; Li, Zhaohai; Liu, Aiyi

    2016-08-30

    A sequential design is proposed to test whether the accuracy of a binary diagnostic biomarker meets the minimal level of acceptance. The accuracy of a binary diagnostic biomarker is a linear combination of the marker's sensitivity and specificity. The objective of the sequential method is to minimize the maximum expected sample size under the null hypothesis that the marker's accuracy is below the minimal level of acceptance. The exact results of two-stage designs based on Youden's index and efficiency indicate that the maximum expected sample sizes are smaller than the sample sizes of the fixed designs. Exact methods are also developed for estimation, confidence interval and p-value concerning the proposed accuracy index upon termination of the sequential testing. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. PMID:26947768

  13. Mission Control Center (MCC) System Specification for the Shuttle Orbital Flight Test (OFT) Timeframe

    NASA Technical Reports Server (NTRS)

    1976-01-01

    System specifications to be used by the mission control center (MCC) for the shuttle orbital flight test (OFT) time frame were described. The three support systems discussed are the communication interface system (CIS), the data computation complex (DCC), and the display and control system (DCS), all of which may interfere with, and share processing facilities with other applications processing supporting current MCC programs. The MCC shall provide centralized control of the space shuttle OFT from launch through orbital flight, entry, and landing until the Orbiter comes to a stop on the runway. This control shall include the functions of vehicle management in the area of hardware configuration (verification), flight planning, communication and instrumentation configuration management, trajectory, software and consumables, payloads management, flight safety, and verification of test conditions/environment.

  14. The Reliability, Validity and Applicability of Two Sport-Specific Power Tests in Synchronized Swimming

    PubMed Central

    Peric, Mia; Zenic, Natasa; Mandic, Gordana Furjan; Sekulic, Damir; Sajber, Dorica

    2012-01-01

    Sport-specific tests are rarely investigated in synchronized swimming (synchro). The aim of this research was to study the reliability and the validity of two sport-specific tests that are based on synchro elements, namely, the Barracuda thrust (“Barracuda”) and the Boost. The Barracuda is a move in which the swimmer begins in the back pike position (head down with the legs perpendicular to the surface of the water) and then moves the legs and hips rapidly upward, unrolling the body to obtain a maximal vertical position above the surface of the water. The Boost occurs when the swimmer rises rapidly out of the water, head first, to bring as much of the body as possible above the surface of the water. Both patterns are considered power moves and are therefore theoretically related to explosive strength. This study involved 22 female competitive synchro swimmers aged 16–18 years. The variables examined included performance on the Barracuda, Boost and countermovement jump and anthropometric measures (body height, body weight and body composition). Statistical analyses showed appropriate reliability for all tests, with no systematic bias between trials. A factor analysis calculated for the Barracuda, Boost and countermovement jump revealed one significant factor based on the Guttmann-Kaiser criterion with all three tests significantly projected. The structure of the significant factor did not change if the results for the Boost and Barracuda were normalized for body height. The Boost and Barracuda, but not the countermovement jump, were significantly correlated with the competitive achievements of the swimmers. In conclusion, the Boost and Barracuda are reliable and valid measures of the explosive strength of synchronized swimmers and are significantly related to competitive achievement. PMID:23487473

  15. Comment on "football-specific fitness testing: adding value or confirming the evidence?".

    PubMed

    Carling, Christopher; Collins, Dave

    2014-01-01

    The recent point-counter-point exchange arising from the article by Mendez-Villanueva and Buchheit (2013) (Football-specific fitness testing: Adding value or confirming the evidence? Journal of Sports Sciences, 31, 1503-1508) has generated an interesting debate on the real-world utility of fitness testing in professional association football (soccer). In the present authors' opinion, this exchange could also have been placed more in the context of the physical testing and subsequent benchmark profiling of the youth player within elite academy talent identification and development processes. This point is further strengthened by the current media debate at the time of writing on the development of elite youth football players in England and the Elite Player Performance Plan or EPPP (The Premier League. (2011). Elite Player Performance Plan. London: Author) published by the English Premier League as part of a vision for the future development of youth football in the League and throughout the English professional game. The EPPP recommends the implementation of a national database to enable comparison of Academy player performances against national physical testing "benchmark" profiles. In continuing the above debate, this letter questions the real-world utility and potential pitfalls of nationwide athletic benchmark profiling programmes for elite youth football. PMID:24878103

  16. Performance and specificity rates in the Test of Memory Malingering: an investigation into pediatric clinical populations.

    PubMed

    Loughan, Ashlee R; Perna, Robert

    2014-01-01

    Symptom validity tests are becoming standard as an effort measure during pediatric neuropsychological assessment. An important component of symptom validity test use is understanding limitations of these measures and how select clinical groups may have difficulty with them. Research has begun to clarify the limits of the Test of Memory Malingering (TOMM) with diverse childhood diagnoses. This study compared TOMM scores of children (N = 86) classified with common childhood disorders. Findings suggest that a substantial proportion of children performed below the recommended cutoff score of 45 on Trial 2 and attained varied specificity rates. This included children with conduct disorders (85%), affective disorders (92%), traumatic brain injury (83%), attention-deficit hyperactivity disorder (93%), learning disabilities (100%), and pervasive developmental disorder (88%). The group with the most children scoring below the cutoff was children with intellectual disabilities (76%). This finding is consistent with some of the adult research suggesting that very limited cognitive ability may compromise TOMM performance. Caution may be necessary when drawing conclusions about test-taking effort based on the recommended TOMM cutoff scores when evaluating children with disabilities. PMID:24236938

  17. Comparison of test specific sediment effect concentrations with marine sediment quality assessment guidelines

    SciTech Connect

    Carr, R.S.; Biedenbach, J.M.; Long, E.R.; MacDonald, D.D.

    1995-12-31

    As part of NOAA`s National Status and Trends (NS and T) Bioeffects Assessment program and studies conducted by the National Biological Service, numerous sediment quality assessment surveys have recently been conducted along the Atlantic and Gulf coasts of the US using the sea urchin (Arbacia punctulata) fertilization and embryological development tests with pore water. Additional toxicity tests were also conducted in conjunction with most of these studies. The areas that have been sampled include Boston harbor, Massachusetts; Charleston Harbor, Winyah Bay, and Savannah River, South Carolina; St. Simon Sound, Georgia; Biscayne Bay, Tampa Bay, Choctawhatchee Bay, Apalachicola Bay, St. Andrew Bay, and Pensacola Bay, Florida; Galveston Bay, Lavaca Bay, and Sabine Lake, Texas, and 200 stations in the vicinity of offshore oil and gas production platforms in the Gulf of Mexico. Sufficient data are now available from this series of surveys to calculate test specific sediment effect concentrations (SECs). Based on these recent studies, SECs were developed for the sea urchin porewater and amphipod tests and compared with existing marine sediment quality assessment guidelines.

  18. 22 CFR 196.4 - Administering office.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Administering office. 196.4 Section 196.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.4 Administering office. The Department of...

  19. 16 CFR 0.4 - Laws administered.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Laws administered. 0.4 Section 0.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.4 Laws administered. The Commission exercises enforcement and administrative authority under the Federal Trade Commission Act (15 U.S.C....

  20. 16 CFR 0.4 - Laws administered.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Laws administered. 0.4 Section 0.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.4 Laws administered. The Commission exercises enforcement and administrative authority under the Federal Trade Commission Act (15 U.S.C....

  1. 7 CFR 247.3 - Administering agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administering agencies. 247.3 Section 247.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.3 Administering agencies....

  2. Relaxation processes in administered-rate pricing

    NASA Astrophysics Data System (ADS)

    Hawkins, Raymond J.; Arnold, Michael R.

    2000-10-01

    We show how the theory of anelasticity unifies the observed dynamics and proposed models of administered-rate products. This theory yields a straightforward approach to rate model construction that we illustrate by simulating the observed relaxation dynamics of two administered rate products. We also demonstrate how the use of this formalism leads to a natural definition of market friction.

  3. Predicting Grades in Specific College Freshman Courses from ACT Test Scores and Self-Reported High School Grades. November 1987.

    ERIC Educational Resources Information Center

    Noble, Julie P.; Sawyer, Richard

    The validity of American College Testing Program (ACT) test scores and self-reported high school grades for predicting grades in specific college freshman courses was studied. Specific course grades are typically used to place students in remedial, standard, or advanced classes. These placement decisions, in turn, have immediate implications for…

  4. Development of a polymerase chain reaction test for specific identification of the urinary tract pathogen Aerococcus urinae.

    PubMed Central

    Aguirre, M; Collins, M D

    1993-01-01

    A polymerase chain reaction test was developed for identification of the gram-positive urinary tract pathogen Aerococcus urinae. Oligonucleotide primers were based on highly specific sequences within the small-subunit rRNA gene. A confirmatory test based on hybridization of the amplified products to a highly specific internal probe was also developed. Images PMID:7684752

  5. 2016 Focused Update: Clinical Recommendations for Cardiopulmonary Exercise Testing Data Assessment in Specific Patient Populations.

    PubMed

    Guazzi, Marco; Arena, Ross; Halle, Martin; Piepoli, Massimo F; Myers, Jonathan; Lavie, Carl J

    2016-06-14

    In the past several decades, cardiopulmonary exercise testing (CPX) has seen an exponential increase in its evidence base. The growing volume of evidence in support of CPX has precipitated the release of numerous scientific statements by societies and associations. In 2012, the European Association for Cardiovascular Prevention & Rehabilitation and the American Heart Association developed a joint document with the primary intent of redefining CPX analysis and reporting in a way that would streamline test interpretation and increase clinical application. Specifically, the 2012 joint scientific statement on CPX conceptualized an easy-to-use, clinically meaningful analysis based on evidence-vetted variables in color-coded algorithms; single-page algorithms were successfully developed for each proposed test indication. Because of an abundance of new CPX research in recent years and a reassessment of the current algorithms in light of the body of evidence, a focused update to the 2012 scientific statement is now warranted. The purposes of this update are to confirm algorithms included in the initial scientific statement not requiring revision, to propose revisions to algorithms included in the initial scientific statement, to propose new algorithms based on emerging scientific evidence, to further clarify the application of oxygen consumption at ventilatory threshold, to describe CPX variables with an emerging scientific evidence base, to describe the synergistic value of combining CPX with other assessments, to discuss personnel considerations for CPX laboratories, and to provide recommendations for future CPX research. PMID:27143685

  6. Test and evaluation document for DOT Specification 7A type A packaging. Volume 1

    SciTech Connect

    Kelly, D L

    1997-08-04

    The US Department of Energy (DOE) has been conducting, through several of its operating contractors, an evaluation and testing program to qualify Type A radioactive material packagings per US Department of Transportation (DOT) Specification 7A (DOT-7A) of the Code of Federal Regulations (CFR), Title 49, Part 178 (49 CFR 178). This document summarizes the evaluation and testing performed for all of the packagings successfully qualified in this program. This document supersedes DOE Evaluation Document for DOT-7A Type A Packaging (Edling 1987), originally issued in 1987 by Monsanto Research Corporation Mound Laboratory (MLM), Miamisburg, Ohio, for the Department of Energy, Security Evaluation Program (I)P-4. Mound Laboratory issued four revisions to the document between November 1988 and December 1989. In September 1989, the program was transferred to Westinghouse Hanford Company (Westinghouse Hanford) in Richland, Washington. One additional revision was issued in March 1990 by Westinghouse Hanford. This revision reflects the earlier material and incorporates a number of changes. Evaluation and testing activities on 1208 three DOT-7A Program Dockets resulted in the qualification of three new packaging configurations, which are incorporated herein and summarized. This document presents approximately 300 different packagings that have been determined to meet the requirements for a DOT-7A, type A packaging per 49 CFR 178.350.

  7. Signal processing and display interface studies. [performance tests - design analysis/equipment specifications

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Signal processing equipment specifications, operating and test procedures, and systems design and engineering are described. Five subdivisions of the overall circuitry are treated: (1) the spectrum analyzer; (2) the spectrum integrator; (3) the velocity discriminator; (4) the display interface; and (5) the formatter. They function in series: (1) first in analog form to provide frequency resolution, (2) then in digital form to achieve signal to noise improvement (video integration) and frequency discrimination, and (3) finally in analog form again for the purpose of real-time display of the significant velocity data. The formatter collects binary data from various points in the processor and provides a serial output for bi-phase recording. Block diagrams are used to illustrate the system.

  8. A dedicated system for topographical working memory: evidence from domain-specific interference tests.

    PubMed

    Piccardi, L; Nori, R; Boccia, M; Barbetti, S; Verde, P; Guariglia, C; Ferlazzo, F

    2015-08-01

    In the present study, we used single- and dual-task conditions to investigate the nature of topographical working memory to better understand what type of task can hamper performance during navigation. During dual-task conditions, we considered four different sources of interference: motor (M), spatial motor (SM), verbal (i.e. articulatory suppression AS) and spatial environmental (SE). In order to assess the nature of topographical working memory, we used the Walking Corsi Test, asking the participants to perform two tasks simultaneously (M, SM, AS and SE). Our results showed that only spatial-environmental interference hampers the execution of a topographical working memory task, suggesting a task-domain-specific effect. We also found general gender differences in the topographical working memory capabilities: men were more proficient than women, regardless of the type of interferences. However, like men, women performed worse when a spatial-environmental interference was present. PMID:26003128

  9. An extremely sensitive species-specific ARMS PCR test for the presence of tiger bone DNA.

    PubMed

    Wetton, Jon H; Tsang, Carol S F; Roney, Chris A; Spriggs, Adrian C

    2002-04-18

    The survival of the tiger (Panthera tigris) is seriously threatened by poaching to provide raw materials for traditional Chinese medicines (TCMs). Most highly prized are the tiger's bones, which are used in combination with other animal and plant derivatives in pills and plasters for the treatment of rheumatism and other ailments. Hundreds of patent remedies have been produced which claim to contain tiger bone, but proof of its presence is needed if legislation prohibiting the trade in endangered species is to be enforced.A highly sensitive tiger-specific real-time PCR assay has been developed to address this problem. Using primers specific to the tiger mitochondrial cytochrome b gene, successful amplification has been reliably achieved from blood, hair and bone as well as from a range of TCMs spiked with 0.5% tiger bone. Although capable of detecting fewer than 10 substrate molecules, the seven varieties of TCM pills and plasters tested showed no detectable trace of tiger DNA before spiking. Furthermore, sequencing several "tiger bone" fragments seized from TCM shops has shown that they actually originated from cattle and pigs. The potential effects of traditional bone preparation methods, evidence that much lower concentrations are used than alleged on TCM packaging, and substitution of bones from other species all suggest a low likelihood of detecting tiger DNA in patent medicines. Despite this, the basic methods have been thoroughly proven and can be readily applied to derivatives from other Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) protected species, providing a rapid and highly sensitive forensic test for species of origin. Potential applications to the monitoring of wild populations are demonstrated by the successful identification of shed hairs and faecal samples. PMID:12084490

  10. Test Anxiety among College Students with Specific Reading Disability (Dyslexia): Nonverbal Ability and Working Memory as Predictors

    ERIC Educational Resources Information Center

    Nelson, Jason M.; Lindstrom, Will; Foels, Patricia A.

    2015-01-01

    Test anxiety and its correlates were examined with college students with and without specific reading disability (RD; n = 50 in each group). Results indicated that college students with RD reported higher test anxiety than did those without RD, and the magnitude of these differences was in the medium range on two test anxiety scales. Relative to…

  11. Degradation in PV Encapsulation Transmittance: An Interlaboratory Study Towards a Climate-Specific Test: Preprint

    SciTech Connect

    Miller, David C.; Annigoni, Eleonora; Ballion, Amal; Bokria, Jayesh G.; Bruckman, Laura S.; Burns, David M.; Chen, Xinxin; Elliott, Lamont; Feng, Jiangtao; French, Roger H.; Fowler, Sean; Gu, Xiaohong; Hacke, Peter L.; Honeker, Christian C.; Kempe, Michael D.; Khonkar, Hussam; Kohl, Michael; Perret-Aebi, Laure-Emmanuelle; Phillips, Nancy H.; Scott, Kurt P.; Sculati-Meillaud, Fanny; Shioda, Tsuyos

    2015-08-12

    Reduced optical transmittance of encapsulants resulting from ultraviolet (UV) degradation has frequently been identified as a cause of decreased PV module performance through the life of service in the field. The present module safety and qualification standards, however, apply short UV doses only capable of examining design robustness or 'infant mortality' failures. Essential information that might be used to screen encapsulation through product lifetime remains unknown. For example, the relative efficacy of xenon-arc and UVA-340 fluorescent sources or the typical range of activation energy for degradation is not quantified. We have conducted an interlaboratory experiment to provide the understanding that will be used towards developing a climate- and configuration-specific (UV) weathering test. Five representative, known formulations of EVA were studied in addition to one TPU material. Replicate laminated silica/polymer/silica specimens are being examined at 14 institutions using a variety of indoor chambers (including Xenon, UVA-340, and metal-halide light sources) or field aging. The solar-weighted transmittance, yellowness index, and the UV cut-off wavelength, determined from the measured hemispherical transmittance, are examined to provide understanding and guidance for the UV light source (lamp type) and temperature used in accelerated UV aging tests.

  12. Degradation in PV Encapsulation Transmittance: An Interlaboratory Study Toward a Climate-Specific Test

    SciTech Connect

    Miller, David C.; Hacke, Peter L.; Kempe, Michael D.; Wohlgemuth, John H.; Annigoni, Eleonora; Sculati-Meillaud, Fanny; Ballion, Amal; Kohl, Michael; Bokria, Jayesh G.; Bruckman, Laura S.; French, Roger H.; Burns, David; Phillips, Nancy H.; Feng; Jiangtao; Elliott, Lamont; Scott, Kurt P.; Fowler, Sean; Gu, Xiaohong; Honeker, Christian C.; Khonkar, Hussam; Perret-Aebi, Laure-Emmanuelle; Shioda, Tsy

    2015-06-14

    Reduced optical transmittance of encapsulation resulting from ultraviolet (UV) degradation has frequently been identified as a cause of decreased PV module performance through the life of installations in the field. The present module safety and qualification standards, however, apply short UV doses only capable of examining design robustness or 'infant mortality' failures. Essential information that might be used to screen encapsulation through product lifetime remains unknown. For example, the relative efficacy of xenon-arc and UVA-340 fluorescent sources or the typical range of activation energy for degradation is not quantified. We have conducted an interlaboratory experiment to provide the understanding that will be used towards developing a climate- and configuration-specific (UV) weathering test. Five representative, known formulations of EVA were studied in addition to one TPU material. Replicate laminated silica/polymer/silica specimens are being examined at 14 institutions using a variety of indoor chambers (including Xe, UVA-340, and metal-halide light sources) or field aging. The solar-weighted transmittance, yellowness index, and the UV cut-off wavelength, determined from the measured hemispherical transmittance, are examined to provide understanding and guidance for the UV light source (lamp type) and temperature used in accelerated UV aging tests. Index Terms -- reliability, durability, thermal activation.

  13. Degradation in PV Encapsulation Transmittance: An Interlaboratory Study Towards a Climate-Specific Test

    SciTech Connect

    Miller, David C.; Annigoni, Eleonora; Ballion, Amal; Bokria, Jayesh G.; Bruckman, Laura S.; Burns, David M.; Chen, Xinxin; Elliott, L.; Feng, J.; French, Roger H.; Fowler, S.; Gu, X.; Hacke, Peter L.; Honeker, C. C.; Kempe, Michael D.; Khonkar, H.; Kohl, M.; Perret-Aebi, Laure-Emmanuelle; Phillips, N. H.; Scott, K. P.; Sculati-Meillaud, F.; Shioda, T.; Suga, S.; Watanabe, S.; Wohlgemuth, John H.

    2015-06-14

    Reduced optical transmittance of encapsulants resulting from ultraviolet (UV) degradation has frequently been identified as a cause of decreased PV module performance through the life of service in the field. The present module safety and qualification standards, however, apply short UV doses only capable of examining design robustness or 'infant mortality' failures. Essential information that might be used to screen encapsulation through product lifetime remains unknown. For example, the relative efficacy of xenon-arc and UVA-340 fluorescent sources or the typical range of activation energy for degradation is not quantified. We have conducted an interlaboratory experiment to provide the understanding that will be used towards developing a climate- and configuration-specific (UV) weathering test. Five representative, known formulations of EVA were studied in addition to one TPU material. Replicate laminated silica/polymer/silica specimens are being examined at 14 institutions using a variety of indoor chambers (including Xenon, UVA-340, and metal-halide light sources) or field aging. The solar-weighted transmittance, yellowness index, and the UV cut-off wavelength, determined from the measured hemispherical transmittance, are examined to provide understanding and guidance for the UV light source (lamp type) and temperature used in accelerated UV aging tests.

  14. Specificity and false positive rates of the Test of Memory Malingering, Rey 15-item Test, and Rey Word Recognition Test among forensic inpatients with intellectual disabilities.

    PubMed

    Love, Christopher M; Glassmire, David M; Zanolini, Shanna Jordan; Wolf, Amanda

    2014-10-01

    This study evaluated the specificity and false positive (FP) rates of the Rey 15-Item Test (FIT), Word Recognition Test (WRT), and Test of Memory Malingering (TOMM) in a sample of 21 forensic inpatients with mild intellectual disability (ID). The FIT demonstrated an FP rate of 23.8% with the standard quantitative cutoff score. Certain qualitative error types on the FIT showed promise and had low FP rates. The WRT obtained an FP rate of 0.0% with previously reported cutoff scores. Finally, the TOMM demonstrated low FP rates of 4.8% and 0.0% on Trial 2 and the Retention Trial, respectively, when applying the standard cutoff score. FP rates are reported for a range of cutoff scores and compared with published research on individuals diagnosed with ID. Results indicated that although the quantitative variables on the FIT had unacceptably high FP rates, the TOMM and WRT had low FP rates, increasing the confidence clinicians can place in scores reflecting poor effort on these measures during ID evaluations. PMID:24671735

  15. Correlation among skin prick test, total and specific IgE UniCAP tests in atopic patients from Zagreb, Croatia.

    PubMed

    Milavec-Puretić, Visnja; Lipozencić, Jasna; Zizić, Vesna; Milavec, Dinko

    2004-01-01

    The correlation of pollen allergens, Dermatophagoides pteronyssinus and animal dender was assessed during a two-year period. Results of skin prick test, total and specific IgE UniCAP tests were compared in atopic patients (AP) with the following diagnoses: atopic dermatitis, allergic rhinitis, allergic conjunctivitis, allergic bronchitis or asthma, allergic urticaria and angioedema. The study included total and specific IgE (in vitro) tests to allergen mixtures (grass, tree, weed) or to single allergens of Dermatophagoides pteronyssinus (Der p), cat and dog fur, feather, etc. Comparison of skin prick test with total and specific IgE UniCAP immunoassay was done in 173 patients, i.e. 107 female and 66 male atopic patients aged 9-76 years. Allergies were most commonly recorded in the 25-35 age group. Total IgE ranged from 8.63 kU/l to >4000 kU/l, with specific IgE ranging from class 1 to class 5. Skin prick test showed high correlation with specific IgE for grass and weed pollen in patients with repiratory allergy (50.28%). Good correlation among all three tests was quite frequently observed. The results suggest that the study should be continued using these three tests in further cases of atopic dermatitis. PMID:15588558

  16. Rare attributes in finite universe: Hypotheses testing specification and exact randomized upper confidence bounds

    SciTech Connect

    Wright, T.

    1993-03-01

    When attributes are rare and few or none are observed in the selected sample from a finite universe, sampling statisticians are increasingly being challenged to use whatever methods are available to declare with high probability or confidence that the universe is near or completely attribute-free. This is especially true when the attribute is undesirable. Approximations such as those based on normal theory are frequently inadequate with rare attributes. For simple random sampling without replacement, an appropriate probability distribution for statistical inference is the hypergeometric distribution. But even with the hypergeometric distribution, the investigator is limited from making claims of attribute-free with high confidence unless the sample size is quite large using nonrandomized techniques. In the hypergeometric setting with rare attributes, exact randomized tests of hypothesis a,re investigated to determine the effect on power of how one specifies the null hypothesis. In particular, specifying the null hypothesis as zero attributes does not always yield maximum possible power. We also consider the hypothesis specification question under complex sampling designs including stratified random sampling and two-stage cluster sampling (one case involves random selection at first stage and another case involves probability proportional to size without replacement selection at first stage). Also under simple random sampling, this article defines and presents a simple algorithm for the construction of exact ``randomized`` upper confidence bounds which permit one to possibly report tighter bounds than those exact bounds obtained using ``nonrandomized`` methods.

  17. Rare attributes in finite universe: Hypotheses testing specification and exact randomized upper confidence bounds

    SciTech Connect

    Wright, T.

    1993-03-01

    When attributes are rare and few or none are observed in the selected sample from a finite universe, sampling statisticians are increasingly being challenged to use whatever methods are available to declare with high probability or confidence that the universe is near or completely attribute-free. This is especially true when the attribute is undesirable. Approximations such as those based on normal theory are frequently inadequate with rare attributes. For simple random sampling without replacement, an appropriate probability distribution for statistical inference is the hypergeometric distribution. But even with the hypergeometric distribution, the investigator is limited from making claims of attribute-free with high confidence unless the sample size is quite large using nonrandomized techniques. In the hypergeometric setting with rare attributes, exact randomized tests of hypothesis a,re investigated to determine the effect on power of how one specifies the null hypothesis. In particular, specifying the null hypothesis as zero attributes does not always yield maximum possible power. We also consider the hypothesis specification question under complex sampling designs including stratified random sampling and two-stage cluster sampling (one case involves random selection at first stage and another case involves probability proportional to size without replacement selection at first stage). Also under simple random sampling, this article defines and presents a simple algorithm for the construction of exact randomized'' upper confidence bounds which permit one to possibly report tighter bounds than those exact bounds obtained using nonrandomized'' methods.

  18. Standardization of the carbon-phenolic materials and processes. Vol. 2: Test methods and specifications

    NASA Technical Reports Server (NTRS)

    Hall, William B.

    1988-01-01

    Carbon-phenolic composite materials are used in the ablation process in the nozzles of the Space Shuttle Main Engine. The nozzle is lined with carbon cloth-phenolic resin composites. The extreme heat and erosion of the burning propellant are controlled by the carbon-phenolic composite by means of ablation, a heat and mass transfer process in which a large amount of heat is dissipated by sacrificailly removing material from a surface. Phenolic materials ablate with the initial formation of a char. The depth of the char is a function of the heat conduction coefficient of the composite. The char layer is a poor conductor so it protects the underlying phenolic composite from the high heat of the burning propellant. The nozzle component ablative liners (carbon cloth-phenolic resin composites) are tape wrapped, hydroclave and/or autoclave cured, machined and assembled. The tape consists of prepreg broadcloth. The materials flow sheet for the nozzle ablative liners is given. The prepreg is a three component system: phenolic resin, carbon cloth, and carbon filler. This is Volume 2 of the report, Test Methods and Specifications.

  19. Self-administered treatment for smoking cessation.

    PubMed

    Curry, Susan J; Ludman, Evette J; McClure, Jennifer

    2003-03-01

    Self-administered treatment for smoking cessation has the potential to reach a broad spectrum of the population of smokers. This article focuses on self-administration of behavioral and pharmacological treatments for smoking cessation. Evidence for the effectiveness of written manuals to self-administer behavioral treatment is mixed. There is no evidence that self-help manuals alone are effective. However, they do increase quit rates when combined with personalized adjuncts such as written feedback and outreach telephone counseling. Efficacy trials of first-line pharmacotherapies (nicotine gum, nicotine patch, and bupropion) result in doubling of cessation rates compared to placebo. It is difficult to evaluate the effectiveness of pharmacotherapies when self-administered under real-world conditions. The general consensus is that they improve quit rates, although poor compliance and early discontinuation reduce their effectiveness. Areas for further research include randomized trials of the use of new technologies (e.g., hand-held computers and the Internet) to disseminate self-administered treatments as well as improved surveillance of the use of self-administered treatment in population-based health surveys. PMID:12579547

  20. 40 CFR Table C-1 to Subpart C of... - Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Test Concentration Ranges, Number of... Reference Methods Pt. 53, Subpt. C, Table C-1 Table C-1 to Subpart C of Part 53—Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications Pollutant Concentration...

  1. 40 CFR Table C-1 to Subpart C of... - Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 6 2014-07-01 2014-07-01 false Test Concentration Ranges, Number of... Reference Methods Pt. 53, Subpt. C, Table C-1 Table C-1 to Subpart C of Part 53—Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications Pollutant Concentration...

  2. 40 CFR Table C-1 to Subpart C of... - Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 6 2012-07-01 2012-07-01 false Test Concentration Ranges, Number of... Reference Methods Pt. 53, Subpt. C, Table C-1 Table C-1 to Subpart C of Part 53—Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications Pollutant Concentration...

  3. Weighting Tasks from Job Analysis Data To Derive Test Specifications for Licensure Examinations: Some Methodological and Statistical Considerations.

    ERIC Educational Resources Information Center

    Thomas, Leslie; Kalohn, John C.

    Test specifications dictate the kind of content that should be included on each form of an examination, and the relative weight that each content domain should contribute to the determination of examinees' test scores by specifying the proportion of items to be included in each content area. This paper addresses a step in the development of…

  4. Language Learner Strategies and Linguistic Competence as Factors Affecting Achievement Test Scores in English for Specific Purposes

    ERIC Educational Resources Information Center

    Jurkovic, Violeta

    2010-01-01

    The article examines the effect of two factors on achievement test scores in English as a foreign language for specific purposes in higher education: preexisting linguistic competence and frequency of use of language learner strategies. The rationale for the analysis of language learner strategies as a factor affecting achievement test outcomes is…

  5. 40 CFR Table C-1 to Subpart C of... - Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specifications C Table C-1 to Subpart C of Part 53 Protection of... Reference Methods Pt. 53, Subpt. C, Table C-1 Table C-1 to Subpart C of Part 53—Test Concentration...

  6. Unidimensional IRT Item Parameter Estimates across Equivalent Test Forms with Confounding Specifications within Dimensions

    ERIC Educational Resources Information Center

    Matlock, Ki Lynn; Turner, Ronna

    2016-01-01

    When constructing multiple test forms, the number of items and the total test difficulty are often equivalent. Not all test developers match the number of items and/or average item difficulty within subcontent areas. In this simulation study, six test forms were constructed having an equal number of items and average item difficulty overall.…

  7. Francais langue seconde. Livret d'examen des eleves--Niveau debutant, premiere et deuxieme parties (French as a Second Language. Test Booklet--Beginning Level, Parts One and Two) [and] Guide D'accompagnement pour administrer le test modele--Niveau debutant (User's Guide for Administering Model Test--Beginning Level).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    This document consists of the separately published test booklet, two student answer booklets, and test administration guide for Alberta's beginning-level French as a second language test. The student test booklet contains instructions, largely in English, and questions, largely in French, on aspects of daily life in and out of school. Three…

  8. Power Supply System for the Atlas Experiment: Design Specifications, Implementation, Test and First Results

    NASA Astrophysics Data System (ADS)

    Lazzaroni, M.; Citterio, M.; Latorre, S.; Lanza, A.; Cova, P.; Delmonte, N.; Giuliani, F.

    2014-06-01

    The planned upgrade of instrumentation sensitivity in the ATLAS experiment of the Large Hadron Collider (LHC), at CERN, calls for a new type of power distribution architecture. Moreover, power supplies require DC-DC power converters able to work in very hostile environment and maintaining high level of Reliability, Availability, Maintainability and Safety (denoted as RAMS requirements) during the experimental activity. Two main issues need to be discussed: first, electronic devices and equipment must operate in very high background of both charged and neutral particles and high static magnetic field and, second, the increase of the radiation background and the requirements of new front-end electronics are indeed incompatible with the current capability of the actual distribution system. The APOLLO R&D collaboration, funded by the Italian Istituto Nazionale di Fisica Nucleare (INFN), aims to study dedicated topologies of both distribution system and DC-DC power converters and to design, build and test demonstrators, developing the needed technology for the industrialization phase. The collaboration has designed a 3kW, 280V-12V converter (MC) based on the Switch in Line architecture (SIL), a DC to DC phase-shifted converter characterized by a disposition in line of the MOSFETs with good soft switching performances, and in the last year many steps have been taken to enhance the power dissipation and the reliability and to improve the general features of the designed converter. In particular a new water heat sink was designed on the basis of TFD simulation accounting for the layout of the specific converter. Experimental activities in order to characterize both thermal and electrical features of the MC confirm the correctness of the adopted design criteria.

  9. Substrate specificity of proteolytic activity in the testes fluid and seminal plasma of the common carp Cyprinus carpio.

    PubMed

    Cejko, B I; Słowińska, M; Judycka, S; Kowalski, R K

    2016-05-01

    Substrate specificity in the seminal plasma and testes fluids of the common carp Cyprinus carpio was determined using gelatin, casein, albumin and haemoglobin. Proteolytic profiles of the testes and seminal plasma were compared. Different ranges of pH (5·5-9·5) and temperature (4-37° C) were used during incubations of seminal plasma proteinases. Differences in proteolytic activity between testes and seminal plasma may reflect specific functions of the testes and sperm ducts in semen production. Seminal plasma metalloproteinases were characterized by higher substrate specificity than were serine proteinases. Zymography optimization for seminal plasma indicated that pH 7·5 and 22° C were the optimal conditions for gel incubations. PMID:27001550

  10. 49 CFR 180.407 - Requirements for test and inspection of specification cargo tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 30.5 cm (12-inch) bottom leg (end bent to a 12.7 mm (0.5 inch) radius), or equally sensitive probe... and water, or using other equally sensitive methods. (2) When testing an insulated cargo tank, the... Delivery Tank Using Pressure-Vacuum Test,” as set forth in Appendix A to 40 CFR part 60. Test methods...

  11. Factors Influencing the Selection of Standardized Tests for the Diagnosis of Specific Language Impairment

    ERIC Educational Resources Information Center

    Betz, Stacy K.; Eickhoff, Jessica R.; Sullivan, Shanleigh F.

    2013-01-01

    Purpose: Standardized tests are one of the primary assessment tools used by speech-language pathologists (SLPs) to diagnose child language impairment. Numerous child language tests are commercially available; however, it is unknown what factors lead clinicians to select particular tests to use in clinical practice. This study investigated whether…

  12. 49 CFR 180.407 - Requirements for test and inspection of specification cargo tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Delivery Tank Using Pressure-Vacuum Test,” as set forth in Appendix A to 40 CFR part 60. Test methods and procedures and maximum allowable pressure and vacuum changes are in 40 CFR 63.425(e). The hydrostatic test... affecting § 180.407, see the List of CFR Sections Affected, which appears in the Finding Aids section of...

  13. 49 CFR 180.407 - Requirements for test and inspection of specification cargo tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Delivery Tank Using Pressure-Vacuum Test,” as set forth in Appendix A to 40 CFR part 60. Test methods and procedures and maximum allowable pressure and vacuum changes are in 40 CFR 63.425(e). The hydrostatic test... affecting § 180.407, see the List of CFR Sections Affected, which appears in the Finding Aids section of...

  14. 49 CFR 180.407 - Requirements for test and inspection of specification cargo tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Delivery Tank Using Pressure-Vacuum Test,” as set forth in Appendix A to 40 CFR part 60. Test methods and procedures and maximum allowable pressure and vacuum changes are in 40 CFR 63.425(e). The hydrostatic test... affecting § 180.407, see the List of CFR Sections Affected, which appears in the Finding Aids section of...

  15. Block 4 solar cell module design and test specification for intermediate load center applications

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Requirements for performance of terrestrial solar cell modules intended for use in various test applications are established. During the 1979-80 time period, such applications are expected to be in the 20 to 500 kilowatt size range. A series of characterization and qualification tests necessary to certify the module design for production, and the necessary performance test for acceptance of modules are specified.

  16. 49 CFR 180.407 - Requirements for test and inspection of specification cargo tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Delivery Tank Using Pressure-Vacuum Test,” as set forth in Appendix A to 40 CFR part 60. Test methods and procedures and maximum allowable pressure and vacuum changes are in 40 CFR 63.425(e). The hydrostatic test... affecting § 180.407, see the List of CFR Sections Affected which appears in the Finding Aids section of...

  17. Changes in Medications Administered in Schools

    ERIC Educational Resources Information Center

    McCarthy, Ann Marie; Kelly, Michael W.; Johnson, Shella; Roman, Jaclyn; Zimmerman, M. Bridget

    2006-01-01

    The purpose of this descriptive, cross-sectional study was to determine if there have been changes in the type and number of attention deficit/hyperactivity disorder (AD/HD) medications administered in schools since the introduction of long-acting stimulants. A survey was sent to 1,000 school nurses randomly selected from the National Association…

  18. Prostate specific antigen testing in family practice: a cross sectional survey of self-reported rates of and reasons for testing participation and risk disclosure

    PubMed Central

    2013-01-01

    Background Despite controversy about the benefits of routine prostate specific antigen (PSA) testing, rates of participation continue to rise. It is important to ensure that men are fully informed about the potential risks associated with this test. Little is known about the processes of shared decision making for PSA testing in the family practice setting. This study aimed to explore men’s experiences of PSA testing participation and risk disclosure for PSA testing. Methods A cross-sectional survey of male family practice attendees aged 40 years or older, with no previous history of prostate cancer, between June 2010 and November 2011. Questions related to whether participants had undertaken PSA testing or discussed this with their doctor over the past 5 years, whether the patient or doctor had initiated the discussion, reasons for undergoing testing, and whether their doctor had discussed particular risks associated with PSA testing. Results Sixty-seven percent (215/320) of men recalled having a PSA test in the past five years. Of the respondents who reported not having a test, 14% had discussed it with their doctor. The main reasons for having a PSA test were doctor recommendation and wanting to keep up to date with health tests. Thirty-eight percent or fewer respondents reported being advised of each potential risk. Conclusions Despite debate over the benefits of routine PSA testing, a high proportion of male family practice attendees report undertaking this test. Risks associated with testing appear to be poorly disclosed by general practitioners. These results suggest the need to improve the quality of informed consent for PSA testing in the family practice setting. PMID:24321004

  19. Failings of trauma-specific and related psychological tests in detecting post-traumatic stress disorder in forensic settings.

    PubMed

    Kleinman, Stuart B; Martell, Daniel

    2015-01-01

    Judges and juries tend to be particularly impressed by test data, especially quantitative test data. Psychometric tests specific for assessing the presence of post-traumatic stress disorder (PTSD) are commonly employed by forensic mental health evaluators. Most of these instruments, however, have been designed to detect PTSD in treatment or research, and not forensic, settings. Those who rely on these measures without adequate awareness of their often significant limits in correctly identifying malingering may induce finders of fact to inordinately confidently accept the presence of PTSD. This article reviews problematic structural and content components of trauma-specific and related instruments used to evaluate PTSD and discusses the utility of specific techniques liable to be used in forensic settings to "fool" these measures. PMID:25425278

  20. Relation between occupational asthma case history, bronchial methacholine challenge, and specific challenge test in patients with suspected occupational asthma.

    PubMed

    Baur, X; Huber, H; Degens, P O; Allmers, H; Ammon, J

    1998-02-01

    Inhalative methacholine challenge (MC) was performed in 229 subjects presumed to suffer from occupational asthma due to exposure to airborne latex allergens (n = 62), flour (n = 28), isocyanates (n = 114), or irritants in hairdressers' salons (n = 25). They were also subjected to specific challenges with the occupational agents they were exposed to, completed a questionnaire using an abbreviated version of the ATS-DLD, and were interviewed by an experienced physician. Bronchial hyperresponsiveness in MC was defined by the results obtained in a previous study with 81 healthy volunteers. The threshold in these controls was set at a cumulative MC dose of 0.3 mg, corresponding to a sensitivity of 95%. The main purpose of the study was to investigate whether the MC and/or the occupational asthma case history are reliable predictors of the specific challenge test outcomes. In 40-72% of examined subjects, workplace-related asthma complaints occurred, with bronchial hyperreactivity in the MC ranging from 48% to 61%. However, only 12-25% demonstrated a significant bronchoconstructive reaction in the specific challenge test. MC results are only moderately associated with workplace-related asthma case histories. Positive outcomes of challenges with occupational agents are well correlated with positive MC results plus occupational asthma case histories. The combination of MC and occupational asthma case history shows a relatively high specificity (62%, 86%, 80%), but the sensitivity was moderately low (83%, 71%, 52%). MC sensitivities were 92%, 71%, and 62% (case histories of hairdressers were not available). We conclude that in most cases, occupational asthma (as defined by a specific challenge test response) is combined with bronchial hyperresponsiveness and workplace-related asthmatic symptoms. However, subjects of each exposure group demonstrated bronchial hyperresponsiveness and complained of workplace-related asthmatic symptoms, but occupational asthma could not be

  1. The Measurement of Mental Retardation by a Culture-Specific Test

    ERIC Educational Resources Information Center

    Long, Peggie A.; Anthony, John J.

    1974-01-01

    This study determines whether Black students who have been placed in an EMR program on the basis of WISC full scale IQ scores as the primary criterion measure would be ruled out when tested on the BITCH. Results indicate that students obtain similar scores on both tests. (Author)

  2. Analyzing Student Performance in Specific Subject Area Indicators on the ETS Major Field Test in Business

    ERIC Educational Resources Information Center

    Settlage, Daniel Murray; Wollscheid, Jim R.

    2015-01-01

    The Major Field Test is a commonly used assessment instrument, but little emphasis has been put on analyzing student-level subject area indicator scores. The Educational Testing Service recently made these data available to institutions, and it is analyzed here. This analysis builds on previous work by incorporating demographic and programmatic…

  3. 12 CFR Appendix A to Subpart B of... - Risk-Based Capital Test Methodology and Specifications

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Risk-Based Capital Test Methodology and... OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS CAPITAL Risk-Based Capital Pt. 1750, Subpt. B, App. A Appendix A to Subpart B of Part 1750—Risk-Based Capital Test Methodology...

  4. 12 CFR Appendix A to Subpart B of... - Risk-Based Capital Test Methodology and Specifications

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Risk-Based Capital Test Methodology and... OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS CAPITAL Risk-Based Capital Pt. 1750, Subpt. B, App. A Appendix A to Subpart B of Part 1750—Risk-Based Capital Test Methodology...

  5. Item Banking for State and Local Test Development and Use: Specific Guidelines for Local Practitioners.

    ERIC Educational Resources Information Center

    Estes, Gary D.; Arter, Judith A.

    A project to assist with improving test efficiency in local school districts and state agencies is described. The report describes and defines the term "item banking." Considerations in selecting, developing, or managing an item bank are discussed. Testing purposes considered suitable for item banking include student selection for special…

  6. Are Multiple Choice Tests Fair to Medical Students with Specific Learning Disabilities?

    ERIC Educational Resources Information Center

    Ricketts, Chris; Brice, Julie; Coombes, Lee

    2010-01-01

    The purpose of multiple choice tests of medical knowledge is to estimate as accurately as possible a candidate's level of knowledge. However, concern is sometimes expressed that multiple choice tests may also discriminate in undesirable and irrelevant ways, such as between minority ethnic groups or by sex of candidates. There is little literature…

  7. Development of a grinding-specific performance test set-up.

    PubMed

    Olesen, C G; Larsen, B H; Andresen, E L; de Zee, M

    2015-01-01

    The aim of this study was to develop a performance test set-up for America's Cup grinders. The test set-up had to mimic the on-boat grinding activity and be capable of collecting data for analysis and evaluation of grinding performance. This study included a literature-based analysis of grinding demands and a test protocol developed to accommodate the necessary physiological loads. This study resulted in a test protocol consisting of 10 intervals of 20 revolutions each interspersed with active resting periods of 50 s. The 20 revolutions are a combination of both forward and backward grinding and an exponentially rising resistance. A custom-made grinding ergometer was developed with computer-controlled resistance and capable of collecting data during the test. The data collected can be used to find measures of grinding performance such as peak power, time to complete and the decline in repeated grinding performance. PMID:25367077

  8. Application specific Tester-On-a-Resident-Chip (TORCH{trademark}) - innovation in the area of semiconductor testing

    SciTech Connect

    Bowles, M.; Peterson, T.; Savignon, D.; Campbell, D.

    1997-12-01

    Manufacturers widely recognize testing as a major factor in the cost, producability, and delivery of product in the $100 billion integrated circuit business: {open_quotes}The rapid development of VLSI using sub-micron CMOS technology has suddenly exposed traditional test techniques as a major cost factor that could restrict the development of VLSI devices exceeding 512 pins an operating frequencies above 200 MHz.{close_quotes} -- 1994 Semiconductor Industry Association Roadmap, Design and Test, Summary, pg. 43. This problem increases dramatically for stockpile electronics, where small production quantities make it difficult to amortize the cost of increasingly expensive testers. Application of multiple ICs in Multi-Chip Modules (MCM) greatly multiplies testing problems for commercial and defense users alike. By traditional test methods, each new design requires custom test hardware and software and often dedicated testing equipment costing millions of dollars. Also, physical properties of traditional test systems often dedicated testing equipment costing millions of dollars. Also, physical properties of traditional test systems limit capabilities in testing at-speed (>200 MHz), high-impedance, and high-accuracy analog signals. This project proposed a revolutionary approach to these problems: replace the multi-million dollar external test system with an inexpensive test system integrated onto the product wafer. Such a methodology enables testing functions otherwise unachievable by conventional means, particularly in the areas of high-frequency, at-speed testing, high impedance analog circuits, and known good die assessment. The techniques apply specifically to low volume applications, typical of Defense Programs, where testing costs represent an unusually high proportional of product costs, not easily amortized.

  9. Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses

    PubMed Central

    2010-01-01

    Background Dengue is a major public health problem in tropical and subtropical countries. Rapid and easy diagnosis of dengue can assist patient triage and care-management. The detection of DENV NS1 on rapid lateral flow tests offers a fast route to a presumptive dengue diagnosis but careful evaluations are urgently needed as more and more people use them. Methods The sensitivity and specificity of the Bio-Rad NS1 Ag Strip and SD Dengue Duo (NS1/IgM/IgG) lateral flow rapid tests were evaluated in a panel of plasma samples from 245 Vietnamese patients with RT-PCR confirmed dengue and 47 with other febrile illnesses. Results The NS1 rapid tests had similar diagnostic sensitivities (respectively 61.6% and 62.4%) in confirmed dengue cases but were 100% specific. When IgM/IgG results from the SD Dengue Duo were included in the test interpretation, the sensitivity improved significantly from 62.4% with NS1 alone to 75.5% when NS1 and/or IgM was positive and 83.7% when NS1 and/or IgM and/or IgG was positive. Both NS1 assays were significantly more sensitive for primary than secondary dengue. NS1 positivity was associated with the underlying viraemia as NS1-positive samples had a significantly higher viraemia than NS1-negative samples. Conclusions These data suggest that the NS1 test component of these assays are highly specific and have similar levels of sensitivity. The IgM parameter in the SD Duo test improved overall test sensitivity without compromising specificity. The SD Dengue Duo lateral flow rapid test deserves further prospective evaluation in dengue endemic settings. PMID:20509940

  10. Informed consent in direct-to-consumer personal genome testing: the outline of a model between specific and generic consent.

    PubMed

    Bunnik, Eline M; Janssens, A Cecile J W; Schermer, Maartje H N

    2014-09-01

    Broad genome-wide testing is increasingly finding its way to the public through the online direct-to-consumer marketing of so-called personal genome tests. Personal genome tests estimate genetic susceptibilities to multiple diseases and other phenotypic traits simultaneously. Providers commonly make use of Terms of Service agreements rather than informed consent procedures. However, to protect consumers from the potential physical, psychological and social harms associated with personal genome testing and to promote autonomous decision-making with regard to the testing offer, we argue that current practices of information provision are insufficient and that there is a place--and a need--for informed consent in personal genome testing, also when it is offered commercially. The increasing quantity, complexity and diversity of most testing offers, however, pose challenges for information provision and informed consent. Both specific and generic models for informed consent fail to meet its moral aims when applied to personal genome testing. Consumers should be enabled to know the limitations, risks and implications of personal genome testing and should be given control over the genetic information they do or do not wish to obtain. We present the outline of a new model for informed consent which can meet both the norm of providing sufficient information and the norm of providing understandable information. The model can be used for personal genome testing, but will also be applicable to other, future forms of broad genetic testing or screening in commercial and clinical settings. PMID:23137034

  11. Administering social security: challenges yesterday and today.

    PubMed

    Puckett, Carolyn

    2010-01-01

    In 2010, the Social Security Administration (SSA) celebrates the 75th anniversary of the passage of the Social Security Act. In those 75 years, SSA has been responsible for programs providing unemployment insurance, child welfare, and supervision of credit unions, among other duties. This article focuses on the administration of the Old-Age, Survivors, and Disability Insurance program, although it also covers some of the other major programs SSA has been tasked with administering over the years-in particular, Medicare, Black Lung benefits, and Supplemental Security Income. The article depicts some of the challenges that have accompanied administering these programs and the steps that SSA has taken to meet those challenges. Whether implementing complex legislation in short timeframes or coping with natural disasters, SSA has found innovative ways to overcome problems and has evolved to meet society's changing needs. PMID:20737858

  12. Computer system requirements specification for 101-SY hydrogen mitigation test project data acquisition and control system (DACS-1)

    SciTech Connect

    McNeece, S.G.; Truitt, R.W.

    1994-10-12

    The system requirements specification for SY-101 hydrogen mitigation test project (HMTP) data acquisition and control system (DACS-1) documents the system requirements for the DACS-1 project. The purpose of the DACS is to provide data acquisition and control capabilities for the hydrogen mitigation testing of Tank SY-101. Mitigation testing uses a pump immersed in the waste, directed at varying angles and operated at different speeds and time durations. Tank and supporting instrumentation is brought into the DACS to monitor the status of the tank and to provide information on the effectiveness of the mitigation test. Instrumentation is also provided for closed loop control of the pump operation. DACS is also capable for being expanded to control and monitor other mitigation testing. The intended audience for the computer system requirements specification includes the SY-101 hydrogen mitigation test data acquisition and control system designers: analysts, programmers, instrument engineers, operators, maintainers. It is intended for the data users: tank farm operations, mitigation test engineers, the Test Review Group (TRG), data management support staff, data analysis, Hanford data stewards, and external reviewers.

  13. Development of a PCR test system for specific detection of Salmonella Paratyphi B in foods.

    PubMed

    Zhai, Ligong; Yu, Qian; Bie, Xiaomei; Lu, Zhaoxin; Lv, Fengxia; Zhang, Chong; Kong, Xiaohan; Zhao, Haizhen

    2014-06-01

    Salmonella enterica serotype Paratyphi B is a globally distributed human-specific pathogen causing paratyphoid fever. The aim of this study was to develop a rapid and reliable polymerase chain reaction (PCR) assay for its detection in food. The SPAB_01124 gene was found to be unique to S. Paratyphi B using comparative genomics. Primers for fragments of the SPAB_01124 gene and the Salmonella-specific invA gene were used in combination to establish a multiplex PCR assay that showed 100% specificity across 45 Salmonella strains (representing 34 serotypes) and 18 non-Salmonella strains. The detection limit was 2.2 CFU mL(-1) of S. Paratyphi B after 12-h enrichment in pure culture. It was shown that co-culture with S. Typhimurium or Escherichia coli up to concentrations of 3.6 × 10(5)  CFU and 3.3 × 10(4)  CFU, respectively, did not interfere with PCR detection of S. Paratyphi B. In artificially contaminated milk, the assay could detect as few as 62 CFU mL(-1) after 8 h of enrichment. In conclusion, comparative genomics was found to be an efficient approach to the mining of pathogen-specific target genes, and the PCR assay that was developed from this provided a rapid, specific, and sensitive method for detection of S. Paratyphi B. PMID:24725227

  14. Noninvasive Imaging of Administered Progenitor Cells

    SciTech Connect

    Steven R Bergmann, M.D., Ph.D.

    2012-12-03

    The objective of this research grant was to develop an approach for labeling progenitor cells, specifically those that we had identified as being able to replace ischemic heart cells, so that the distribution could be followed non-invasively. In addition, the research was aimed at determining whether administration of progenitor cells resulted in improved myocardial perfusion and function. The efficiency and toxicity of radiolabeling of progenitor cells was to be evaluated. For the proposed clinical protocol, subjects with end-stage ischemic coronary artery disease were to undergo a screening cardiac positron emission tomography (PET) scan using N-13 ammonia to delineate myocardial perfusion and function. If they qualified based on their PET scan, they would undergo an in-hospital protocol whereby CD34+ cells were stimulated by the administration of granulocytes-colony stimulating factor (G-CSF). CD34+ cells would then be isolated by apharesis, and labeled with indium-111 oxine. Cells were to be re-infused and subjects were to undergo single photon emission computed tomography (SPECT) scanning to evaluate uptake and distribution of labeled progenitor cells. Three months after administration of progenitor cells, a cardiac PET scan was to be repeated to evaluate changes in myocardial perfusion and/or function. Indium oxine is a radiopharmaceutical for labeling of autologous lymphocytes. Indium-111 (In-111) decays by electron capture with a t{sub ½} of 67.2 hours (2.8 days). Indium forms a saturated complex that is neutral, lipid soluble, and permeates the cell membrane. Within the cell, the indium-oxyquinolone complex labels via indium intracellular chelation. Following leukocyte labeling, ~77% of the In-111 is incorporated in the cell pellet. The presence of red cells and /or plasma reduces the labeling efficacy. Therefore, the product needed to be washed to eliminate plasma proteins. This repeated washing can damage cells. The CD34 selected product was a 90

  15. 49 CFR 180.509 - Requirements for inspection and test of specification tank cars.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (5) Optically-aided visual inspection (e.g., magnifiers, fiberscopes, borescopes, and machine vision... reliability of the test method and for the serviceability of components to prevent premature failure....

  16. Single event upset test structures for digital CMOS application specific integrated circuits

    SciTech Connect

    Baze, M.P.; Bartholet, W.G.; Braatz, J.C.; Dao, T.A. )

    1993-12-01

    An approach has been developed for the design and utilization of SEU test structures for digital CMOS ASICs. This approach minimizes the number of test structures required by categorizing ASIC library cells according to their SEU response and designing a structure to characterize each response for each category. Critical SEU response parameters extracted from these structures are used to evaluate the SEU hardness of ASIC libraries and predict the hardness of ASIC chips.

  17. Evaluating Operational Specifications of Point-of-Care Diagnostic Tests: A Standardized Scorecard

    PubMed Central

    Lehe, Jonathan D.; Sitoe, Nádia E.; Tobaiwa, Ocean; Loquiha, Osvaldo; Quevedo, Jorge I.; Peter, Trevor F.; Jani, Ilesh V.

    2012-01-01

    The expansion of HIV antiretroviral therapy into decentralized rural settings will increasingly require simple point-of-care (POC) diagnostic tests that can be used without laboratory infrastructure and technical skills. New POC test devices are becoming available but decisions around which technologies to deploy may be biased without systematic assessment of their suitability for decentralized healthcare settings. To address this, we developed a standardized, quantitative scorecard tool to objectively evaluate the operational characteristics of POC diagnostic devices. The tool scores devices on a scale of 1–5 across 30 weighted characteristics such as ease of use, quality control, electrical requirements, shelf life, portability, cost and service, and provides a cumulative score that ranks products against a set of ideal POC characteristics. The scorecard was tested on 19 devices for POC CD4 T-lymphocyte cell counting, clinical chemistry or hematology testing. Single and multi-parameter devices were assessed in each of test categories. The scores across all devices ranged from 2.78 to 4.40 out of 5. The tool effectively ranked devices within each category (p<0.01) except the CD4 and multi-parameter hematology products. The tool also enabled comparison of different characteristics between products. Agreement across the four scorers for each product was high (intra-class correlation >0.80; p<0.001). Use of this tool enables the systematic evaluation of diagnostic tests to facilitate product selection and investment in appropriate technology. It is particularly relevant for countries and testing programs considering the adoption of new POC diagnostic tests. PMID:23118871

  18. Selecting and evaluating native plants for region-specific phytotoxicity testing.

    PubMed

    Olszyk, David; Pfleeger, Thomas; Lee, E Henry; Burdick, Connie; King, George; Plocher, Milton; Kern, Jeffrey

    2008-01-01

    In this study, we evaluated methodology to determine risks to terrestrial native plant species from potential herbecide drift, focusing on 1) selection of native species for testing, 2) growth of these species, and 3) variability in herbicide response among native species and compared with crop plants. Native plant species were selected for initial testing on the basis of spatial analysis, which indicated that species from Illinois, USA, were at potential risk for off-target effects of herbicide drift. On the basis of preliminary seed germination tests, 5 native plant species (Andropogon gerardi, Polygonum lapathifolium, Solidago canadensis, Symphyotrichum lateriflorum, and Tridens flavus) were selected for comparison with crops grown in Illinois, normally used in the US Environmental Protection Agency's (USEPA's) Vegetative Vigor Test (Avena sativa, Daucus carota, Glycine max, Solanum lycopersicon, and Zea mays), or both. When treated with low concentrations of a test herbicide, sulfometuron methyl, 2 native species, P. lapathifolium and S. canadensis, were as sensitive as the 5 crop species. The effective herbicide concentrations producing a 25% reduction in shoot dry weight (EC25) for these species, ranged from 0.00015 to 0.0014 times a field application concentration of 52 g/ha active ingredient of sulfometuron methyl. S. lateriflorum and T. flavus were less sensitive than the other native species, whereas A. gerardi was tolerant to sulfometuron methyl with no growth reduction at any herbicide concentration tested. This study indicated that native species can be successfully selected and grown, used in the suite of species used in the USEPA's phytotoxicity test to assess risks of chemical herbicides to nontarget plants. It also showed (with a limited number of species) that native species varied more in sensitivity to simulated herbicide drift than crop species often used in phytotoxicity testing and that a Weibull function was useful to calculate EC25 values

  19. A Bayesian hierarchical model with novel prior specifications for estimating HIV testing rates.

    PubMed

    An, Qian; Kang, Jian; Song, Ruiguang; Hall, H Irene

    2016-04-30

    Human immunodeficiency virus (HIV) infection is a severe infectious disease actively spreading globally, and acquired immunodeficiency syndrome (AIDS) is an advanced stage of HIV infection. The HIV testing rate, that is, the probability that an AIDS-free HIV infected person seeks a test for HIV during a particular time interval, given no previous positive test has been obtained prior to the start of the time, is an important parameter for public health. In this paper, we propose a Bayesian hierarchical model with two levels of hierarchy to estimate the HIV testing rate using annual AIDS and AIDS-free HIV diagnoses data. At level one, we model the latent number of HIV infections for each year using a Poisson distribution with the intensity parameter representing the HIV incidence rate. At level two, the annual numbers of AIDS and AIDS-free HIV diagnosed cases and all undiagnosed cases stratified by the HIV infections at different years are modeled using a multinomial distribution with parameters including the HIV testing rate. We propose a new class of priors for the HIV incidence rate and HIV testing rate taking into account the temporal dependence of these parameters to improve the estimation accuracy. We develop an efficient posterior computation algorithm based on the adaptive rejection metropolis sampling technique. We demonstrate our model using simulation studies and the analysis of the national HIV surveillance data in the USA. PMID:26567891

  20. A Bayesian hierarchical model with novel prior specifications for estimating HIV testing rates

    PubMed Central

    An, Qian; Kang, Jian; Song, Ruiguang; Hall, H. Irene

    2016-01-01

    Human immunodeficiency virus (HIV) infection is a severe infectious disease actively spreading globally, and acquired immunodeficiency syndrome (AIDS) is an advanced stage of HIV infection. The HIV testing rate, that is, the probability that an AIDS-free HIV infected person seeks a test for HIV during a particular time interval, given no previous positive test has been obtained prior to the start of the time, is an important parameter for public health. In this paper, we propose a Bayesian hierarchical model with two levels of hierarchy to estimate the HIV testing rate using annual AIDS and AIDS-free HIV diagnoses data. At level one, we model the latent number of HIV infections for each year using a Poisson distribution with the intensity parameter representing the HIV incidence rate. At level two, the annual numbers of AIDS and AIDS-free HIV diagnosed cases and all undiagnosed cases stratified by the HIV infections at different years are modeled using a multinomial distribution with parameters including the HIV testing rate. We propose a new class of priors for the HIV incidence rate and HIV testing rate taking into account the temporal dependence of these parameters to improve the estimation accuracy. We develop an efficient posterior computation algorithm based on the adaptive rejection metropolis sampling technique. We demonstrate our model using simulation studies and the analysis of the national HIV surveillance data in the USA. PMID:26567891

  1. Immunodiagnosis of Paracoccidioidomycosis due to Paracoccidioides brasiliensis Using a Latex Test: Detection of Specific Antibody Anti-gp43 and Specific Antigen gp43

    PubMed Central

    dos Santos, Priscila Oliveira; Rodrigues, Anderson Messias; Fernandes, Geisa Ferreira; da Silva, Silvia Helena Marques; Burger, Eva; de Camargo, Zoilo Pires

    2015-01-01

    Background Paracoccidioidomycosis (PCM) is a life-threatening systemic disease and is a neglected public health problem in many endemic regions of Latin America. Though several diagnostic methods are available, almost all of them present with some limitations. Method/Principle Findings A latex immunoassay using sensitized latex particles (SLPs) with gp43 antigen, the immunodominant antigen of Paracoccidioides brasiliensis, or the monoclonal antibody mAb17c (anti-gp43) was evaluated for antibody or antigen detection in sera, cerebrospinal fluid (CSF), and bronchoalveolar lavage (BAL) from patients with PCM due to P. brasiliensis. The gp43-SLPs performed optimally to detect specific antibodies with high levels of sensitivity (98.46%, 95% CI 91.7–100.0), specificity (93.94%, 95% CI 87.3–97.7), and positive (91.4%) and negative (98.9%) predictive values. In addition, we propose the use of mAb17c-SLPs to detect circulating gp43, which would be particularly important in patients with immune deficiencies who fail to produce normal levels of immunoglobulins, achieving good levels of sensitivity (96.92%, 95% CI 89.3–99.6), specificity (88.89%, 95% CI 81.0–94.3), and positive (85.1%) and negative (97.8%) predictive values. Very good agreement between latex tests and double immune diffusion was observed for gp43-SLPs (k = 0.924) and mAb17c-SLPs (k = 0.850), which reinforces the usefulness of our tests for the rapid diagnosis of PCM in less than 10 minutes. Minor cross-reactivity occurred with sera from patients with other fungal infections. We successfully detected antigens and antibodies from CSF and BAL samples. In addition, the latex test was useful for monitoring PCM patients receiving therapy. Conclusions/Significance The high diagnostic accuracy, low cost, reduced assay time, and simplicity of this new latex test offer the potential to be commercialized and makes it an attractive diagnostic assay for use not only in clinics and medical mycology laboratories, but

  2. Technical Report on Development of USES Specific Aptitude Test Battery for Proof-Machine Operator (Banking) 217.388.

    ERIC Educational Resources Information Center

    Manpower Administration (DOL), Washington, DC. U.S. Employment Service.

    Research which resulted in the development of the United States Employment Service Specific Aptitude Test Battery for use in selecting inexperienced or untrained individuals for training as proof-machine operators is described. Occupational norms were established in terms of each significant aptitude measure which when combined, predict job…

  3. Host specificity testing of the Solenopsis fire ant (Hymenoptera:Formicidae) pathogen, Kneallhazia (=Thelohania) solenopsae (Microsporidia:Thelohaniidae), in Florida

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Post-entry host specificity testing was conducted on ants in Florida for the fire ant pathogen Kneallhazia solenopsae to determine transmission potential to native and non-target species. In addition, there was interest to assess the potential of K. solenopsae to control other pest ants. The patho...

  4. CFL Labeling Harmonization in the United States, China, Brazil andELI Member Countries: Specifications, Testing, and MutualRecognition

    SciTech Connect

    Fridley, David; Lin, Jiang; Denver, Andrea; Biermayer, Peter; Dillavou, Tyler

    2005-07-20

    This report examines critical differences among energy-efficient labeling programs for CFLs in Brazil, China, the United States, and the seven members of the international Efficient Lighting Initiative (ELI) in terms of technical specifications and test procedures, and review issues related to international harmonization of these standards.

  5. Technical Report on Development of USES Specific Aptitude Test Battery for Nurse Aid (Medical Ser.) 355.878.

    ERIC Educational Resources Information Center

    Manpower Administration (DOL), Washington, DC. U.S. Employment Service.

    Research which resulted in the development of the United States Employment Service Specific Aptitude Test Battery for use in selecting inexperienced and untrained individuals for training as nurse aids is described. Occupational norms were established in terms of each significant aptitude measure which when combined, predict job performance.…

  6. Host-specificity testing on Leipothrix dipsacivagus (Acari: Eriophyidae), a candidate for biological control of Dipsacus spp.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Leipothrix dipsacivagus Petanovic & Rector is the first eriophyid mite recorded from hosts in the genus Dipsacus and is considered a potential candidate for biological control of invasive teasels (Dipsacaceae). Host-specificity testing on Leipothrix dipsacivagus (Acari: Eriophyidae) was carried out ...

  7. Specificity of treadmill and cycle ergometer tests in triathletes, runners and cyclists.

    PubMed

    Basset, F A; Boulay, M R

    2000-02-01

    The objective of this study was to evaluate the viability of using a single test in which cardiorespiratory variables are measured, to establish training guidelines in running and/or cycling training activities. Six triathletes (two females and four males), six runners (two females and four males) and six males cyclists, all with 5.5 years of serious training and still involved in racing, were tested on a treadmill and cycle ergometer. Cardiorespiratory variables [e.g., heart rate (HR), minute ventilation, carbon dioxide output (VCO2)] were calculated relative to fixed percentages of maximal oxygen uptake (VO2max; from 50 to 100%). The entire group of subjects had significantly (P < 0.05) higher values of VO2max on the treadmill compared with the cycle ergometer [mean (SEM) 4.7 (0.8) and 4.4 (0.9) l.min-1, respectively], and differences between tests averaged 10.5% for runners, 6.1% for triathletes and 2.8% for cyclists. A three-way analysis of variance using a 3 x 2 x 6 design (groups x tests x intensities) demonstrated that all factors yielded highly significant F-ratios (P < 0.05) for all variables between tests, even though differences in HR were only 4 beats.min-1. When HR was plotted against a fixed percentage of VO2max, a high correlation was found between tests. These results demonstrate that for triathletes, cyclists and runners, the relationship between HR and percentage of VO2max, obtained in either a treadmill or a cycle ergometer test, may be used independently of absolute VO2max to obtain reference HR values that can be used to monitor their running and/or cycling training bouts. PMID:10638380

  8. Comparison of Four Commercially Available Avidity Tests for Toxoplasma gondii-Specific IgG Antibodies

    PubMed Central

    Breit, L.; Cimon, B.; Franck, J.; Fricker-Hidalgo, H.; Godineau, N.; Houze, S.; Paris, L.; Pelloux, H.; Villena, I.

    2013-01-01

    Toxoplasma infection in pregnant women may cause congenital toxoplasmosis. Diagnosis of infection is based on serological tests aimed at detecting IgM and IgG antibodies against Toxoplasma gondii. However, IgM antibodies are not an accurate marker for discriminating between acute and latent infection. Detection of residual or persistent IgM may occur months or even years after primary infection, while the IgG avidity test is a rapid means of identifying latent infections in pregnant women who exhibit both IgG and IgM anti-Toxoplasma antibodies on initial testing during pregnancy. In this study, we assessed and compared the performances of four commercially available Toxoplasma IgG avidity tests in immunocompetent and immunocompromised patients with acute and latent toxoplasmosis. The positive predictive value of high avidity to confirm latent toxoplasmosis was 100% for all the assays, indicating that high avidity is a hallmark of latent infection. However, the negative predictive value of high avidity ranged from 99.2% (bioMérieux) to 95.3% (Abbott), indicating that acute toxoplasmosis could not be reliably diagnosed based on low IgG avidity alone. Thus, the avidity test provides a rapid means for identifying latent Toxoplasma infection in immunocompetent pregnant women presenting both IgG and IgM anti-Toxoplasma antibodies on initial testing. In terms of cost-effectiveness, avidity testing is a powerful tool that optimizes screening and follow-up of pregnant women while minimizing the costs of screening by avoiding subsequent costly maternal and fetal investigation and unnecessary treatment. The cheapest assay, Vidas Toxo IgG Avidity, also had the best performance for the diagnosis of latent toxoplasmosis. PMID:23239801

  9. Comparison of four commercially available avidity tests for Toxoplasma gondii-specific IgG antibodies.

    PubMed

    Villard, O; Breit, L; Cimon, B; Franck, J; Fricker-Hidalgo, H; Godineau, N; Houze, S; Paris, L; Pelloux, H; Villena, I; Candolfi, E

    2013-02-01

    Toxoplasma infection in pregnant women may cause congenital toxoplasmosis. Diagnosis of infection is based on serological tests aimed at detecting IgM and IgG antibodies against Toxoplasma gondii. However, IgM antibodies are not an accurate marker for discriminating between acute and latent infection. Detection of residual or persistent IgM may occur months or even years after primary infection, while the IgG avidity test is a rapid means of identifying latent infections in pregnant women who exhibit both IgG and IgM anti-Toxoplasma antibodies on initial testing during pregnancy. In this study, we assessed and compared the performances of four commercially available Toxoplasma IgG avidity tests in immunocompetent and immunocompromised patients with acute and latent toxoplasmosis. The positive predictive value of high avidity to confirm latent toxoplasmosis was 100% for all the assays, indicating that high avidity is a hallmark of latent infection. However, the negative predictive value of high avidity ranged from 99.2% (bioMérieux) to 95.3% (Abbott), indicating that acute toxoplasmosis could not be reliably diagnosed based on low IgG avidity alone. Thus, the avidity test provides a rapid means for identifying latent Toxoplasma infection in immunocompetent pregnant women presenting both IgG and IgM anti-Toxoplasma antibodies on initial testing. In terms of cost-effectiveness, avidity testing is a powerful tool that optimizes screening and follow-up of pregnant women while minimizing the costs of screening by avoiding subsequent costly maternal and fetal investigation and unnecessary treatment. The cheapest assay, Vidas Toxo IgG Avidity, also had the best performance for the diagnosis of latent toxoplasmosis. PMID:23239801

  10. Specific 13C functional pathways as diagnostic targets in gastroenterology breath-tests: tricks for a correct interpretation.

    PubMed

    Pizzoferrato, M; Del Zompo, F; Mangiola, F; Lopetuso, L R; Petito, V; Cammarota, G; Gasbarrini, A; Scaldaferri, F

    2013-01-01

    Breath tests are non-invasive, non-radioactive, safe, simple and effective tests able to determine significant metabolic alterations due to specific diseases or lack of specific enzymes. Carbon isotope (13)C, the stable-non radioactive isotope of carbon, is the most used substrate in breath testing, in which (13)C/(12)C ratio is measured and expressed as a delta value, a differences between readings and a fixed standard. (13)C/(12)C ratio is measured with isotope ratio mass spectrometry or non-dispersive isotope-selective infrared spectrometer and generally there is a good agreement between these techniques in the isotope ratio estimation. (13)C/(12)C ratio can be expressed as static measurement (like delta over baseline in urea breath test) or as dynamic measurement as percent dose recovery, but more dosages are necessary. (13)C Breath-tests are involved in many fields of interest within gastroenterology, such as detection of Helicobacter pylori infection, study of gastric emptying, assessment of liver and exocrine pancreatic functions, determination of oro-caecal transit time, evaluation of absorption and to a lesser extend detection of bacterial overgrowth. The use of every single test in a clinical setting is vary depending on accuracy and substrate costs. This review is meant to present (13)C the meaning of (13)C/(12)C ratio and static and dynamic measure and, finally, the instruments dedicated to its use in gastroenterology. A brief presentation of (13)C breath tests in gastroenterology is also provided. PMID:24443068

  11. Assessing Disease Class-Specific Diagnostic Ability: A Practical Adaptive Test Approach.

    ERIC Educational Resources Information Center

    Papa, Frank J.; Schumacker, Randall E.

    Measures of the robustness of disease class-specific diagnostic concepts could play a central role in training programs designed to assure the development of diagnostic competence. In the pilot study, the authors used disease/sign-symptom conditional probability estimates, Monte Carlo procedures, and artificial intelligence (AI) tools to create…

  12. Solenopsis invicta virus 3: Further host-specificity tests with native Solenopsis ants (Hymenoptera: Formicidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A thorough understanding of host specificity is essential before pathogens can be used as biopesticides or self-sustaining biocontrol agents. In order to better define the host range of the recently discovered Solenopsis invicta virus 3 (SINV-3), we collected and exposed colonies of two native fire...

  13. 40 CFR 53.51 - Demonstration of compliance with design specifications and manufacturing and test requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... finish of surfaces specified to be anodized—meet the specifications of 40 CFR part 50, appendix L or... in 40 CFR part 50, appendix L. (c) Sampler manufacturing quality control. The manufacturer must... FRM or FEM and that are specified by design in 40 CFR part 50, appendix L or O (as applicable),...

  14. 40 CFR 53.51 - Demonstration of compliance with design specifications and manufacturing and test requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... finish of surfaces specified to be anodized—meet the specifications of 40 CFR part 50, appendix L or... in 40 CFR part 50, appendix L. (c) Sampler manufacturing quality control. The manufacturer must... FRM or FEM and that are specified by design in 40 CFR part 50, appendix L or O (as applicable),...

  15. 40 CFR 53.51 - Demonstration of compliance with design specifications and manufacturing and test requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... finish of surfaces specified to be anodized—meet the specifications of 40 CFR part 50, appendix L or... in 40 CFR part 50, appendix L. (c) Sampler manufacturing quality control. The manufacturer must... a FRM or FEM and that are specified by design in 40 CFR part 50, appendix L or O (as...

  16. 40 CFR 53.51 - Demonstration of compliance with design specifications and manufacturing and test requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... finish of surfaces specified to be anodized—meet the specifications of 40 CFR part 50, appendix L or... in 40 CFR part 50, appendix L. (c) Sampler manufacturing quality control. The manufacturer must... FRM or FEM and that are specified by design in 40 CFR part 50, appendix L or O (as applicable),...

  17. [The specific characteristics determined by nonbiological tests of mineral-based biomaterials used in dentistry. 7].

    PubMed

    Mongiorgi, R; Valdrè, G; Bottura, G; Bertocchi, G; Minguzzi, V; Corvo, G; Tartaro, G P

    1995-01-01

    In this work we relate about the results coming from crystallographic, physical and mineral tests taken on following biomaterials used in odontostomatology: reabsorbable Dac Blu, non reabsorbable Dac Blu, not reabsorbable atomized Dac Blu, not reabsorbable thin Dac Blu, reabsorbable Biocoral 450, Calcitite 2040-12, Orthogel, Apagen, BTF 65, Calcitite 4060-2, Osprogel, Bio-Oss, Biostite, Osprovit, Merck Hydroxiapatite. The data were obtained using the following tests: XRF, XRD, FTIR, TG, DTG, DTA, SEM. The results, although taken on few samples, showed that these biomaterials present a variability in some features, which can define the structural functionality. PMID:7783713

  18. Proceedings: Nozzle Initiative Industry Advisory Committee on standardization of carbon-phenolic test methods and specifications

    NASA Technical Reports Server (NTRS)

    Hall, William B.

    1992-01-01

    Verbal discussions during the biannual meeting of the Industry Advisory Committee for Carbon-phenolic constituent test methodology, which is constituted under the Solid Propulsion Integrity Program (SPIP), are addressed. The items on the agenda are: (1) NASA video tape library; (2) product code identification; (3) NMR progress; (4) IR and DMTA workshop; (5) aerospace database update; (6) M vision database demonstration; (7) constituent fingerprinting; (8) cured materials test development; (9) engineering needs for computer modeling; and (10) review action items. The materials prepared to support some of the oral presentations are also included in the Appendix.

  19. The NASA broad-specification fuels combustion technology program: An assessment of phase 1 test results

    NASA Technical Reports Server (NTRS)

    Fear, J. S.

    1983-01-01

    An assessment is made of the results of Phase 1 screening testing of current and advanced combustion system concepts using several broadened-properties fuels. The severity of each of several fuels-properties effects on combustor performance or liner life is discussed, as well as design techniques with the potential to offset these adverse effects. The selection of concepts to be pursued in Phase 2 refinement testing is described. This selection takes into account the relative costs and complexities of the concepts, the current outlook on pollutant emissions control, and practical operational problems.

  20. Mission Control Center (MCC) system specification for the shuttle Orbital Flight Test (OFT) timeframe

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The Mission Control Center Shuttle (MCC) Shuttle Orbital Flight Test (OFT) Data System (OFTDS) provides facilities for flight control and data systems personnel to monitor and control the Shuttle flights from launch (tower clear) to rollout (wheels stopped on runway). It also supports the preparation for flight (flight planning, flight controller and crew training, and integrated vehicle and network testing activities). The MCC Shuttle OFTDS is described in detail. Three major support systems of the OFTDS and the data types and sources of data entering or exiting the MCC were illustrated. These systems are the communication interface system, the data computation complex, and the display and control system.

  1. The Hoff circuit test is more specific than an incremental treadmill test to assess endurance with the ball in youth soccer players

    PubMed Central

    Papoti, M; Da Silva, ASR; Barbieri, RA; Campos, EZ; Ferreira, EC; Loures, JP; Chamari, K

    2016-01-01

    The assessment of aerobic endurance is important for training prescription in soccer, and is usually measured by straight running without the ball on a track or treadmill. Due to the ball control and technical demands during a specific soccer test, the running speeds are likely to be lower compared to a continuous incremental test. The aim of the present study was to compare the heart rate (HR), rating of perceived exertion (RPE) and speeds corresponding to 2.0 mmol∙L-1, 3.5 mmol∙L-1, lactate threshold (Dmax method) and peak lactate determined in the laboratory and in the Hoff circuit soccer-specific test. Sixteen soccer players (16±1 years) underwent two incremental tests (laboratory and Hoff circuit tests). The speeds were significantly higher in the treadmill test than on the Hoff circuit (2.0 mmol∙L-1: 9.5±1.2 and 8.1±1.0 km∙h-1; 3.5 mmol∙L-1: 12.0±1.2 and 10.2±1.1 km∙h-1; Dmax: 11.4±1.4 and 9.3±0.4 km∙h-1; peak lactate: 14.9±1.6 and 10.9±0.8 km∙h-1). The HR corresponding to 3.5 mmol∙L-1 was significantly higher on the Hoff circuit compared to the laboratory test (187.5±18.0 and 178.2±17.6 bpm, respectively; P <0.001), while the RPE at the last incremental stage was lower on the Hoff circuit (P < 0.01). The speeds during the Hoff specific soccer test and the HR corresponding to 2.0 mmol∙L-1, 3.5 mmol∙L-1 and Dmax/threshold were different compared with the laboratory test. The present study shows that it is possible to assess submaximal endurance related variables specifically in soccer players. PMID:27601781

  2. The Hoff circuit test is more specific than an incremental treadmill test to assess endurance with the ball in youth soccer players.

    PubMed

    Zagatto, A M; Papoti, M; Da Silva, Asr; Barbieri, R A; Campos, E Z; Ferreira, E C; Loures, J P; Chamari, K

    2016-09-01

    The assessment of aerobic endurance is important for training prescription in soccer, and is usually measured by straight running without the ball on a track or treadmill. Due to the ball control and technical demands during a specific soccer test, the running speeds are likely to be lower compared to a continuous incremental test. The aim of the present study was to compare the heart rate (HR), rating of perceived exertion (RPE) and speeds corresponding to 2.0 mmol∙L(-1), 3.5 mmol∙L(-1), lactate threshold (Dmax method) and peak lactate determined in the laboratory and in the Hoff circuit soccer-specific test. Sixteen soccer players (16±1 years) underwent two incremental tests (laboratory and Hoff circuit tests). The speeds were significantly higher in the treadmill test than on the Hoff circuit (2.0 mmol∙L(-1): 9.5±1.2 and 8.1±1.0 km∙h(-1); 3.5 mmol∙L(-1): 12.0±1.2 and 10.2±1.1 km∙h(-1); Dmax: 11.4±1.4 and 9.3±0.4 km∙h(-1); peak lactate: 14.9±1.6 and 10.9±0.8 km∙h(-1)). The HR corresponding to 3.5 mmol∙L-1 was significantly higher on the Hoff circuit compared to the laboratory test (187.5±18.0 and 178.2±17.6 bpm, respectively; P <0.001), while the RPE at the last incremental stage was lower on the Hoff circuit (P < 0.01). The speeds during the Hoff specific soccer test and the HR corresponding to 2.0 mmol∙L(-1), 3.5 mmol∙L(-1) and Dmax/threshold were different compared with the laboratory test. The present study shows that it is possible to assess submaximal endurance related variables specifically in soccer players. PMID:27601781

  3. Test Anxiety Among College Students With Specific Reading Disability (Dyslexia): Nonverbal Ability and Working Memory as Predictors.

    PubMed

    Nelson, Jason M; Lindstrom, Will; Foels, Patricia A

    2015-01-01

    Test anxiety and its correlates were examined with college students with and without specific reading disability (RD; n = 50 in each group). Results indicated that college students with RD reported higher test anxiety than did those without RD, and the magnitude of these differences was in the medium range on two test anxiety scales. Relative to college students without RD, up to 5 times as many college students with RD reported clinically significant test anxiety. College students with RD reported significantly higher cognitively based test anxiety than physically based test anxiety. Reading skills, verbal ability, and processing speed were not correlated with test anxiety. General intelligence, nonverbal ability, and working memory were negatively correlated with test anxiety, and the magnitude of these correlations was medium to large. When these three cognitive constructs were considered together in multiple regression analyses, only working memory and nonverbal ability emerged as significant predictors and varied based on the test anxiety measure. Implications for assessment and intervention are discussed. PMID:24153402

  4. 40 CFR Appendix A to Part 75 - Specifications and Test Procedures

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... require) performing a flow profile study following the procedures in 40 CFR part 60, appendix A, method, 1... 40 CFR part 60, appendix A, Test Method 1, section 11.5 may be used even if the flow measurement... following: (1) The AETB's quality manual. For the purpose of application of 40 CFR part 2, subpart B,...

  5. SELECTING AND EVALUATING NATIVE PLANTS FOR REGION-SPECIFIC PHYTOTOXICITY TESTING

    EPA Science Inventory

    In this study, we evaluated methodology to determine risks to terrestrial native plant species from potential herbicide drift, focusing on 1) selection of native species for testing, 2) growth of these species, and 3) variability in herbicide response among native species and com...

  6. 40 CFR Appendix A to Part 75 - Specifications and Test Procedures

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... require) performing a flow profile study following the procedures in 40 CFR part 60, appendix A, method, 1... 40 CFR part 60, appendix A, Test Method 1, section 11.5 may be used even if the flow measurement... following: (1) The AETB's quality manual. For the purpose of application of 40 CFR part 2, subpart B,...

  7. 40 CFR Appendix A to Part 75 - Specifications and Test Procedures

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... require) performing a flow profile study following the procedures in 40 CFR part 60, appendix A, method, 1... 40 CFR part 60, appendix A, Test Method 1, section 11.5 may be used even if the flow measurement... manual. For the purpose of application of 40 CFR part 2, subpart B, AETB's concerned about the...

  8. 40 CFR Appendix A to Part 75 - Specifications and Test Procedures

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... measurement point (1) within the centroidal area of the stack or duct cross section, or (2) no less than 1.0... require) performing a flow profile study following the procedures in 40 CFR part 60, appendix A, method, 1... 40 CFR part 60, appendix A, Test Method 1, section 11.5 may be used even if the flow...

  9. Simulating the Effects of Common and Specific Abilities on Test Performance: An Evaluation of Factor Analysis

    ERIC Educational Resources Information Center

    McFarland, Dennis J.

    2014-01-01

    Purpose: Factor analysis is a useful technique to aid in organizing multivariate data characterizing speech, language, and auditory abilities. However, knowledge of the limitations of factor analysis is essential for proper interpretation of results. The present study used simulated test scores to illustrate some characteristics of factor…

  10. 12 CFR Appendix A to Subpart B of... - Risk-Based Capital Test Methodology and Specifications

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... rate at which the security earns interest, as of the reporting date Principal Payment Window Starting... Principal Payment Window Ending Date, Down-Rate Scenario The month in the Stress Test that principal payment... Enterprise projections Principal Payment Window Starting Date, Up-Rate Scenario The month in the Stress...

  11. Cultivating Assessment Literacy: Standards Evaluation through Language-Test Specification Reverse Engineering

    ERIC Educational Resources Information Center

    Walters, F. Scott

    2010-01-01

    The promulgation of ESL learning standards by government agencies and professional organizations is intended to improve second-language (L2) proficiency and academic achievement. However, mandates have been criticized on various grounds, including difficulty of defining domains to be tested as well as vagueness of articulation. Arising from the…

  12. Data-Division-Specific Robustness and Power of Randomization Tests for ABAB Designs

    ERIC Educational Resources Information Center

    Manolov, Rumen; Solanas, Antonio; Bulte, Isis; Onghena, Patrick

    2010-01-01

    This study deals with the statistical properties of a randomization test applied to an ABAB design in cases where the desirable random assignment of the points of change in phase is not possible. To obtain information about each possible data division, the authors carried out a conditional Monte Carlo simulation with 100,000 samples for each…

  13. 21 CFR 866.5520 - Immunoglobulin G (Fab fragment specific) immunological test system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) immunological test system. 866.5520 Section 866.5520 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological... resulting from breakdown of immunoglobulin G antibodies in urine, serum, and other body fluids....

  14. 21 CFR 866.5520 - Immunoglobulin G (Fab fragment specific) immunological test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) immunological test system. 866.5520 Section 866.5520 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological... resulting from breakdown of immunoglobulin G antibodies in urine, serum, and other body fluids....

  15. 21 CFR 866.5520 - Immunoglobulin G (Fab fragment specific) immunological test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) immunological test system. 866.5520 Section 866.5520 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological... resulting from breakdown of immunoglobulin G antibodies in urine, serum, and other body fluids....

  16. 21 CFR 866.5520 - Immunoglobulin G (Fab fragment specific) immunological test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) immunological test system. 866.5520 Section 866.5520 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological... resulting from breakdown of immunoglobulin G antibodies in urine, serum, and other body fluids....

  17. Sex-Specific Differential Prediction of College Admission Tests: A Meta-Analysis

    ERIC Educational Resources Information Center

    Fischer, Franziska T.; Schult, Johannes; Hell, Benedikt

    2013-01-01

    This is the first meta-analysis that investigates the differential prediction of undergraduate and graduate college admission tests for women and men. Findings on 130 independent samples representing 493,048 students are summarized. The underprediction of women's academic performance (d = 0.14) and the overprediction of men's academic performance…

  18. Specificity of the Westerfeld adaptation of the Voges-Proskauer test.

    PubMed

    Speckman, R A; Collins, E B

    1982-07-01

    Aliphatic chain compounds at least four carbons long with vicinal carbonyl groups in the 2,3 positions were detected by the Westerfeld test. Acetoin, which has one carbonyl group and an adjacent hydroxyl group, gave positive results, but methyl action (3-hydroxy-3-methyl-2-butanone) was negative, and subsequent tests supported the conclusion that acetoin is oxidized to diacetyl by alpha-naphthol during the Westerfeld test in the absence or presence of air. 2,3-Pentanedione and 2,3-heptanedione gave positive results, but equimolar concentrations of these compounds gave maximal absorbancy readings that were only 35% (2,3-pentanedione) and 31% (2,3-heptanedione) of those obtained with diacetyl or acetoin. Negative results were obtained with pyruvic acid, 2,3-butylene glycol, and carbon ring compounds (1,2-cyclohexanedione, alloxan, and 3,4-dihydroxy-3-cyclobutene-1,2-dione). alpha-Naphtho could not be replaced in the test by beta-naphthol, 1,2,3,4,-tetrahydroxy-1-naphthol, or 5,6,7,8-tetrahydroxy-1-naphthol. Creatine could not be replaced by arginine, guanidine . HCl, or guanidinoacetic acid. PMID:6751225

  19. Sulfurtransferase and thioredoxin specifically interact as demonstrated by bimolecular fluorescence complementation analysis and biochemical tests

    PubMed Central

    Henne, Melina; König, Nicolas; Triulzi, Tiziana; Baroni, Sara; Forlani, Fabio; Scheibe, Renate; Papenbrock, Jutta

    2015-01-01

    Sulfurtransferases (Strs) and thioredoxins (Trxs) are members of large protein families. Trxs are disulfide reductases and play an important role in redox-related cellular processes. They interact with a broad range of proteins. Strs catalyze the transfer of a sulfur atom from a suitable sulfur donor to nucleophilic sulfur acceptors in vitro, but the physiological roles of these enzymes are not well defined. Several studies in different organisms demonstrate protein–protein interactions of Strs with members of the Trx family. We are interested in investigating the specificity of the interaction between Str and Trx isoforms. In order to use the bimolecular fluorescence complementation (BiFC), several Str and Trx sequences from Arabidopsis thaliana were cloned into the pUC-SPYNE and pUC-SPYCE split-YFP vectors, respectively. Each couple of plasmids containing the sequences for the putative interaction partners were transformed into Arabidopsis protoplasts and screened using a confocal laser scanning microscope. Compartment- and partner-specific interactions could be observed in transformed protoplasts. Replacement of cysteine residues in the redox-active site of Trxs abolished the interaction signal. Therefore, the redox site is not only involved in the redox reaction but also responsible for the interaction with partner proteins. Biochemical assays support a specific interaction among Strs and certain Trxs. Based on the results obtained, the interaction of Strs and Trxs indicates a role of Strs in the maintenance of the cellular redox homeostasis. PMID:26605137

  20. Sulfurtransferase and thioredoxin specifically interact as demonstrated by bimolecular fluorescence complementation analysis and biochemical tests.

    PubMed

    Henne, Melina; König, Nicolas; Triulzi, Tiziana; Baroni, Sara; Forlani, Fabio; Scheibe, Renate; Papenbrock, Jutta

    2015-01-01

    Sulfurtransferases (Strs) and thioredoxins (Trxs) are members of large protein families. Trxs are disulfide reductases and play an important role in redox-related cellular processes. They interact with a broad range of proteins. Strs catalyze the transfer of a sulfur atom from a suitable sulfur donor to nucleophilic sulfur acceptors in vitro, but the physiological roles of these enzymes are not well defined. Several studies in different organisms demonstrate protein-protein interactions of Strs with members of the Trx family. We are interested in investigating the specificity of the interaction between Str and Trx isoforms. In order to use the bimolecular fluorescence complementation (BiFC), several Str and Trx sequences from Arabidopsis thaliana were cloned into the pUC-SPYNE and pUC-SPYCE split-YFP vectors, respectively. Each couple of plasmids containing the sequences for the putative interaction partners were transformed into Arabidopsis protoplasts and screened using a confocal laser scanning microscope. Compartment- and partner-specific interactions could be observed in transformed protoplasts. Replacement of cysteine residues in the redox-active site of Trxs abolished the interaction signal. Therefore, the redox site is not only involved in the redox reaction but also responsible for the interaction with partner proteins. Biochemical assays support a specific interaction among Strs and certain Trxs. Based on the results obtained, the interaction of Strs and Trxs indicates a role of Strs in the maintenance of the cellular redox homeostasis. PMID:26605137

  1. Efficacy of species-specific recA PCR tests in the identification of Burkholderia cepacia complex environmental isolates.

    PubMed

    Dalmastri, Claudia; Pirone, Luisa; Tabacchioni, Silvia; Bevivino, Annamaria; Chiarini, Luigi

    2005-05-01

    In this study, we evaluated if recA species-specific PCR assays could be successfully applied to identify environmental isolates of the widespread Burkholderia cepacia complex (Bcc) species. A total of 729 Bcc rhizosphere isolates collected in different samplings were assigned to the species B. cepacia genomovar I (61), B. cenocepacia recA lineage IIIB (514), B. ambifaria (124) and B. pyrrocinia (30), by means of recA (RFLP) analysis, and PCR tests were performed to assess sensitivity and specificity of recA species-specific primers pairs. B. cepacia genomovar I specific primers produced the expected amplicon with all isolates of the corresponding species (sensitivity, 100%), and cross-reacted with all B. pyrrocinia isolates. On the contrary, B. cenocepacia IIIB primers did not give the expected amplicon in 164 B. cenocepacia IIIB isolates (sensitivity, 68.1%), and isolates of distinct populations showed different sensitivity. B. ambifaria primers failed to amplify a recA-specific fragment only in a few isolates of this species (sensitivity, 93.5%). The absence of specific amplification in a high number of B. cenocepacia rhizosphere isolates indicates that recA specific PCR assays can lead to an underestimation of environmental microorganisms belonging to this bacterial species. PMID:15869960

  2. Self-administered treatments for depression: a review.

    PubMed

    McKendree-Smith, Nancy L; Floyd, Mark; Scogin, Forrest R

    2003-03-01

    Although there are numerous self-help books for depression, relatively few have been empirically tested. However, those that have been used in clinical trials have fared well, with an average effect size roughly equivalent to the average effect size obtained in psychotherapy studies. Computer-based treatments are being developed and appear promising as an alternative to bibliotherapy for those interested in self-administered treatments. This article provides a summary of the depression bibliotherapy literature and discusses several remaining questions such as effectiveness versus efficacy, practice applications, ethics, and future research. PMID:12579545

  3. An "alternating instructions" version of the Autobiographical Memory Test for assessing autobiographical memory specificity in non-clinical populations.

    PubMed

    Dritschel, Barbara; Beltsos, Stamatis; McClintock, Shawn M; Beltosis, Stamatis

    2014-01-01

    There is limited research regarding how executive processes contribute to key cognitive deficits in depression, particularly impoverished retrieval of autobiographical memory. This study tested a novel version of the Autobiographical Memory Test (AMT), the "Alternating Instructions" AMT (AMT-AI), to determine how participants could flexibly retrieve specific and categoric autobiographical memories. The AMT-AI consisted of a standard AMT (AMT-S), a categoric version of the AMT (AMT-R), and a section of alternating instructions (AI) in which the rules required the participant to alternate between retrieval of categoric and specific memories. A total of 49 university students completed the AMT-AI, and self-report measures of depressive symptomatology and ruminative thinking. Results showed that the mean proportion of specific memories recalled on the AMT-AI was significantly lower than on the AMT-S. Also, reduced memory specificity on the AMT-AI, but not the AMT-S, was significantly negatively correlated with increased scores on measures of depressive symptomatology and ruminative thinking. Collectively the data suggested that the AMT-AI, relative to the traditional AMT, may be more sensitive to memory specificity in non-clinical populations. Future research is warranted to further determine the psychometric properties and utility of the AMT-AI. PMID:24215524

  4. Block 4 solar cell module design and test specification for residential applications

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Near-term design, qualification and acceptance requirements are provided for terrestrial solar cell modules suitable for incorporation in photovoltaic power sources (2 kW to 10 kW) applied to single family residential installations. Requirement levels and recommended design limits for selected performance criteria are specified for modules intended principally for rooftop installations. Modules satisfying the requirements of this specification fall into one of two categories, residential panel or residential shingle, both meeting general performance requirements plus additional category peculiar constraints.

  5. Specific yield as determined by type-curve analysis of aquifer-test data

    USGS Publications Warehouse

    Moench, Allen F.

    1994-01-01

    The commonly used analytical solution developed by Neuman for a homogeneous, water-table aquifer assumes that the drainage of pores in the zone above the water table due to lowering of the water table occurs instantaneously. Noninstantaneous drainage of pores in the unsaturated zone accounts for the finding that both type-curve analysis and volume-balance calculations yield values of specific yield that are slightly less than those obtained from laboratory column-drainage experiments. It may also account for a slight underestimation of vertical hydraulic conductivity as obtained by type-curve analysis.

  6. Sociodemographic and health-related predictors of self-reported mammogram, faecal occult blood test and prostate specific antigen test use in a large Australian study

    PubMed Central

    2013-01-01

    Background While several studies have examined factors that influence the use of breast screening mammography, faecal occult blood tests (FOBT) for bowel cancer screening and prostate specific antigen (PSA) tests for prostate disease in Australia, research directly comparing the use of these tests is sparse. We examined sociodemographic and health-related factors associated with the use of these tests in the previous two years either alone or in combination. Methods Cross-sectional analysis of self-reported questionnaire data from 96,711 women and 82,648 men aged 50 or over in The 45 and Up Study in NSW (2006–2010). Results 5.9% of men had a FOBT alone, 44.9% had a PSA test alone, 18.7% had both tests, and 30.6% had neither test. 3.2% of women had a FOBT alone, 56.0% had a mammogram alone, 16.2% had both and 24.7% had neither test. Among men, age and socioeconomic factors were largely associated with having both FOBT and PSA tests. PSA testing alone was largely associated with age, family history of prostate cancer, health insurance status and visiting a doctor. Among women, age, use of hormone replacement therapy (HRT), health insurance status, family history of breast cancer, being retired and not having a disability were associated with both FOBT and mammograms. Mammography use alone was largely associated with age, use of HRT and family history of breast cancer. FOBT use alone among men was associated with high income, living in regional areas and being fully-retired and among women, being fully-retired or sick/disabled. Conclusions These results add to the literature on sociodemographic discrepancies related to cancer screening uptake and highlight the fact that many people are being screened for one cancer when they could be screened for two. PMID:23641775

  7. Pain tests provoke modality-specific cardiovascular responses in awake, unrestrained rats

    PubMed Central

    Rigaud, Marcel; Gemes, Geza; Abram, Stephen E.; Dean, Caron; Hopp, Francis A.; Stucky, Cheryl L.; Eastwood, Daniel; Tarima, Sergey; Seagard, Jeanne; Hogan, Quinn H.

    2010-01-01

    Nociception modulates heart rate (HR) and mean arterial pressure (MAP), suggesting their use as indicators of pain in animals. We explored this with telemetric recording in unrestrained control and neuropathic (spinal nerve ligation) rats. Plantar stimulation was performed emulating techniques commonly used to measure pain, specifically brush stroke, von Frey fiber application, noxious pin stimulation, acetone for cooling, and radiant heating, while recording MAP, HR, and specific evoked somatomotor behaviors (none; simple withdrawal; or sustained lifting, shaking and grooming representing hyperalgesia). Pin produced elevations in both HR and MAP, and greater responses accompanied hyperalgesia behavior compared to simple withdrawal. Von Frey stimulation depressed MAP, and increased HR only when stimulation produced hyperalgesia behavior, suggesting that minimal nociception occurs without this behavior. Brush increased MAP even when no movement was evoked. Cold elevated both HR and MAP whether or not there was withdrawal, but MAP increased more when withdrawal was triggered. Heating consistently depressed HR and MAP, independent of behavior. Other than a greater HR response to pin in animals made hyperalgesic by injury, cardiovascular events evoked by stimulation did not differ between control and neuropathic animals. We conclude that a) thermoregulation rather than pain may dominate responses to heat and cooling stimuli; b) brush and cooling stimuli may be perceived and produce cardiovascular activation without nocifensive withdrawal; c) sensations that produce hyperalgesia behavior are accompanied by greater cardiovascular activation than those producing simple withdrawal; and d) von Frey stimulation lacks cardiovascular evidence of nociception except when hyperalgesia behavior is evoked. PMID:20943317

  8. A test of motor skill-specific action embodiment in ice-hockey players.

    PubMed

    Ong, Nicole T; Lohse, Keith R; Chua, Romeo; Sinnett, Scott; Hodges, Nicola J

    2014-07-01

    To further our understanding of the role of the motor system in comprehending action-related sentences, we compared action experts (athletes) to visual experts (fans) and novices when responding with an action-specific effector (either hand or foot). These conditions allowed inferences about the degree and specificity of embodiment in language comprehension. Ice hockey players, fans and novices made speeded judgments regarding the congruence between an auditorily presented sentence and a subsequently presented picture. Picture stimuli consisted of either hockey or everyday items. Half of these pictures 'matched' the action implied in the preceding sentence. Further, the action in these images involved either primarily the hand or the foot. For everyday items, action-matched items were responded to faster than action-mismatched items. However, only the players and fans showed the action-match effect for hockey items. There were no consistent effector-stimuli compatibility effects, nor skill-based interactions with compatibility, suggesting that the action-match effect was not based on motor ability per se, but rather a construction of the action based on knowledge or visual experience with the hockey related sentences. PMID:24818535

  9. Ocular toxicity from systemically administered xenobiotics

    PubMed Central

    Gokulgandhi, Mitan R; Vadlapudi, Aswani Dutt; Mitra, Ashim K

    2015-01-01

    Introduction The eye is considered as the most privileged organ because of the blood–ocular barrier that acts as a barrier to systemically administered xenobiotics. However, there has been a significant increase in the number of reports on systemic drug-induced ocular complications. If such complications are left untreated, then it may cause permanent damage to vision. Hence, knowledge of most recent updates on ever-increasing reports of such toxicities has become imperative to develop better therapy while minimizing toxicities. Areas covered The article is mainly divided into anterior and posterior segment manifestations caused by systemically administered drugs. The anterior segment is further elaborated on corneal complications where as the posterior segment is focused on optic nerve, retinal and vitreous complications. Furthermore, this article includes recent updates on acute and chronic ocular predicaments, in addition to discussing various associated symptoms caused by drugs. Expert opinion Direct correlation of ocular toxicities due to systemic drug therapy is evident from current literature. Therefore, it is necessary to have detailed documentation of these complications to improve understanding and predict toxicities. We made an attempt to ensure that the reader is aware of the characteristic ocular complications, the potential for irreversible drug toxicity and indications for cessation. PMID:22803583

  10. The effect of exercise on cognitive performance in soccer-specific tests.

    PubMed

    McMorris, T; Graydon, J

    1997-10-01

    Two experiments were carried out to examine the effect of moderate and maximal exercise on the cognitive performance of experienced soccer players. Experiment 1 examined the speed and visual search in familiar (game) and unfamiliar (non-game) contexts. Participants had to detect, as quickly as possible, the presence or absence of a ball in tachistoscopically presented slides. Participants were tested at rest and while exercising at 70 and 100% maximum power output. A main effect of exercise intensity was demonstrated and Tukey post-hoc tests showed that performance during maximal exercise was significantly better than in the other two conditions. We concluded that exercise significantly improves speed of visual search. Experiment 2 examined the effects of exercise on speed of search, speed of decision following ball detection, overall speed of decision and accuracy of decision at rest and while exercising at 70 and 100% maximum power output. A repeated-measures multivariate analysis of variance and Tukey post-hoc tests showed that performance during exercise was significantly better than at rest. Observation of the separate univariate analyses of variance demonstrated that most of the variance could be accounted for by overall speed of decision and speed of decision after ball detection. We concluded that exercise induces not only an improvement in a simple task, like speed of visual search, but also an overall increase in speed of information processing. Theories concerning the effect of emotionally induced arousal on cognitive performance do not accurately predict the effect of physically induced arousal on cognitive tasks. PMID:9386203

  11. Establishment of a sensitive and specific hyper-branched rolling circle amplification assay and test strip for TSV.

    PubMed

    Zhao, Yuran; Yin, Weili; Wang, Ying; Wang, Gongpu; Li, Bafang

    2014-12-01

    A specific padlock probe (PLP) and detection probe were designed to target the capsid protein gene of Taura syndrome virus (TSV), and a hyper-branched rolling circle amplification (HRCA) assay and a corresponding strip-based test were produced. The reaction time and temperature were optimized for both. The PLPs were linked with the target sequence via T4 DNA ligase under conditions of 37°C for 30 min, followed by reaction with Bst DNA polymerase Large Fragment at 61°C for 30 min, and then the test strip was made using the detection probe. Both the assay and the strip had similarly high accuracy and specificity, and their sensitivity was close to 10 copies, which is 100 times higher than that of conventional RT-PCR. We tested 89 batches of shrimps for TSV to assess the HRCA assay and test strip; the results indicated that the TSV HRCA assay and the test strip are rapid diagnostic tools for detection in the field, and have potential for early diagnosis of TSV. PMID:25196450

  12. Full-scale altitude engine test of a turbofan exhaust-gas-forced mixer to reduce thrust specific fuel consumption

    NASA Technical Reports Server (NTRS)

    Cullom, R. R.; Johnson, R. L.

    1977-01-01

    The specific fuel consumption of a low-bypass-ratio, confluent-flow, turbofan engine was measured with and without a mixer installed. Tests were conducted for flight Mach numbers from 0.3 to 1.4 and altitudes from 10,670 to 14,630 meters (35,000 to 48,000 ft) for core-stream-to-fan-stream temperature ratios of 2.0 and 2.5 and mixing-length-to-diameter ratios of 0.95 and 1.74. For these test conditions, the reduction in specific fuel consumption varied from 2.5 percent to 4.0 percent. Pressure loss measurements as well as temperature and pressure surveys at the mixer inlet, the mixer exit, and the nozzle inlet were made.

  13. New real-time PCR tests for species-specific detection of Chlamydophila psittaci and Chlamydophila abortus from tissue samples.

    PubMed

    Pantchev, Alexandra; Sting, Reinhard; Bauerfeind, Rolf; Tyczka, Judith; Sachse, Konrad

    2009-08-01

    Chlamydophila psittaci and Chlamydophila abortus are the causative agents of avian chlamydiosis (psittacosis) and ovine enzootic abortion, respectively. Both pathogens are known to possess zoonotic potential. Due to their close genetic relatedness, direct and rapid species identification is difficult. In the present study, new real-time PCR assays are reported for both species. The tests are based on highly specific probes targeting the ompA gene region and were conducted as duplex PCRs including an internal amplification control. The Cp. psittaci assay successfully passed a proficiency test at national level. Examination of field samples revealed Cp. psittaci as the dominating species in birds, but also Cp. abortus in a few psittacines. Real-time PCR assays for species-specific detection of Cp. psittaci and Cp. abortus are suited for routine diagnosis, which renders them important tools for the recognition of outbreaks of psittacosis and ovine enzootic abortion. PMID:18413292

  14. 40 CFR Table C-1 to Subpart C of... - Test Concentration Ranges, Number of Measurements Required, and Maximum Discrepancy Specification

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Measurements Required, and Maximum Discrepancy Specification C Table C-1 to Subpart C of Part 53 Protection of... Reference Methods Pt. 53, Subpt. C, Table C-1 Table C-1 to Subpart C of Part 53—Test Concentration Ranges... 0.25 to 0.35 2 2 .03 Total 7 8 Effective Date Note: At 75 FR 35601, June 22, 2010, table C-1...

  15. Models provide specificity: Testing a proposed mechanism of visual working memory capacity development

    PubMed Central

    Simmering, Vanessa R.; Patterson, A. Rebecca

    2012-01-01

    Numerous studies have established that visual working memory has a limited capacity, and that capacity increases during childhood. However, debate continues over the source of capacity limits and its developmental increase. Simmering (2008) adapted a computational model of spatial cognitive development, the Dynamic Field Theory, to explain not only the source of capacity limitations but also the developmental mechanism. According to the model, capacity is limited by the balance between excitation and inhibition that maintains multiple neural representations simultaneously. Moreover, development is implemented according to the Spatial Precision Hypothesis, which proposes that excitatory and inhibitory connections strengthen throughout early childhood. Critically, these changes in connectivity result in increasing precision and stability of neural representations over development. Here we test this developmental mechanism by probing children’s memory in a single-item change detection task. Results confirmed the model’s predictions, providing further support for this account of visual working memory capacity development. PMID:23204645

  16. Clinical relevance is associated with allergen-specific wheal size in skin prick testing

    PubMed Central

    Haahtela, T; Burbach, G J; Bachert, C; Bindslev-Jensen, C; Bonini, S; Bousquet, J; Bousquet-Rouanet, L; Bousquet, P J; Bresciani, M; Bruno, A; Canonica, G W; Darsow, U; Demoly, P; Durham, S R; Fokkens, W J; Giavi, S; Gjomarkaj, M; Gramiccioni, C; Kowalski, M L; Losonczy, G; Orosz, M; Papadopoulos, N G; Stingl, G; Todo-Bom, A; von Mutius, E; Köhli, A; Wöhrl, S; Järvenpää, S; Kautiainen, H; Petman, L; Selroos, O; Zuberbier, T; Heinzerling, L M

    2014-01-01

    Background Within a large prospective study, the Global Asthma and Allergy European Network (GA2LEN) has collected skin prick test (SPT) data throughout Europe to make recommendations for SPT in clinical settings. Objective To improve clinical interpretation of SPT results for inhalant allergens by providing quantitative decision points. Methods The GA2LEN SPT study with 3068 valid data sets was used to investigate the relationship between SPT results and patient-reported clinical relevance for each of the 18 inhalant allergens as well as SPT wheal size and physician-diagnosed allergy (rhinitis, asthma, atopic dermatitis, food allergy). The effects of age, gender, and geographical area on SPT results were assessed. For each allergen, the wheal size in mm with an 80% positive predictive value (PPV) for being clinically relevant was calculated. Results Depending on the allergen, from 40% (blatella) to 87–89% (grass, mites) of the positive SPT reactions (wheal size ≥ 3 mm) were associated with patient-reported clinical symptoms when exposed to the respective allergen. The risk of allergic symptoms increased significantly with larger wheal sizes for 17 of the 18 allergens tested. Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults. The 80% PPV varied from 3 to 10 mm depending on the allergen. Conclusion These ‘reading keys’ for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance. A SPT form with the standard allergens including mm decision points for each allergen is offered for clinical use. PMID:24283409

  17. Type-Specific Identification of Anogenital Herpes Simplex Virus Infections by Use of a Commercially Available Nucleic Acid Amplification Test

    PubMed Central

    Warren, Terri; Taylor, Stephanie N.; Martens, Mark; Jerome, Keith R.; Mena, Leandro; Lebed, Joel; Ginde, Savita; Fine, Paul; Hook, Edward W.

    2012-01-01

    Herpes infections are among the most common sexually transmitted infections (STI), but diagnostic methods for genital herpes have not kept pace with the movement toward molecular testing. Here, we describe an FDA-approved molecular assay that identifies and types herpes simplex virus (HSV) infections for use in routine clinical settings. Paired samples from anogenital lesions were tested using the BD ProbeTec HSV Qx (HSVQx) system, HSV culture and, a laboratory-developed PCR assay. Family planning, obstetrics/gynecology (OB/GYN), or sexually transmitted disease (STD) clinics in the United States served as recruitment sites. Sensitivity and specificity estimates, head-to-head comparisons, measures of agreement, and latent-class analyses were performed to provide robust estimates of performance. A total of 508 participants (174 men and 334 women) with anogenital lesions were included; 260 HSV-2 and 73 HSV-1 infections were identified. No differences in test performance based on gender, clinic type, location of the lesion, or type of lesion were observed. The sensitivity of HSV-2 detection ranged from 98.4 to 100% depending on the analytical approach, while the specificity ranged from 80.6%, compared to the less sensitive culture method, to 97.0%, compared to PCR. For HSV-1, the sensitivity and specificity ranges were 96.7 to 100% and 95.1 to 99.4%, respectively. This assay may improve our ability to accurately diagnose anogenital lesions due to herpes infection. PMID:22875892

  18. Analysis of the Sensitivity and Specificity of Noninvasive Imaging Tests for the Diagnosis of Renal Artery Stenosis

    PubMed Central

    Borelli, Flavio Antonio de Oliveira; Pinto, Ibraim M. F.; Amodeo, Celso; Smanio, Paola E. P.; Kambara, Antonio M.; Petisco, Ana Claudia G.; Moreira, Samuel M.; Paiva, Ricardo Calil; Lopes, Hugo Belotti; Sousa, Amanda G. M. R.

    2013-01-01

    Background Aging and atherosclerosis are related to renovascular hypertension in elderly individuals. Regardless of comorbidities, renal artery stenosis is itself an important cause of cardiovascular morbidity and mortality. Objective To define the sensitivity, specificity, positive predictive value, and negative predictive value of noninvasive imaging tests used in the diagnosis of renal artery stenosis. Methods In a group of 61 patients recruited, 122 arteries were analized, thus permitting the definition of sensitivity, specificity, and the relative contribution of each imaging study performed (Doppler, scintigraphy and computed tomographic angiography in comparison to renal arteriography). Results The mean age was 65.43 years (standard deviation: 8.7). Of the variables related to the study population that were compared to arteriography, two correlated with renal artery stenosis, renal dysfunction and triglycerides. The median glomerular filtration rate was 52.8 mL/min/m2. Doppler showed sensitivity of 82.90%, specificity of 70%, a positive predictive value of 85% and negative predictive value of 66.70%. For tomography, sensitivity was 66.70%, specificity 80%, positive predictive value 87.50% and negative predictive value 55.20%. With these findings, we could identify the imaging tests that best detected stenosis. Conclusion Tomography and Doppler showed good quality and efficacy in the diagnosis of renal artery stenosis, with Doppler having the advantage of not requiring the use of contrast medium for the assessment of a disease that is common in diabetics and is associated with renal dysfunction and severe left ventricular dysfunction. PMID:24061685

  19. The Vanderbilt Expertise Test Reveals Domain-General and Domain-Specific Sex Effects in Object Recognition

    PubMed Central

    McGugin, Rankin W.; Richler, Jennifer J.; Herzmann, Grit; Speegle, Magen; Gauthier, Isabel

    2012-01-01

    Individual differences in face recognition are often contrasted with differences in object recognition using a single object category. Likewise, individual differences in perceptual expertise for a given object domain have typically been measured relative to only a single category baseline. In Experiment 1, we present a new test of object recognition, the Vanderbilt Expertise Test (VET), which is comparable in methods to the Cambridge Face Memory Task (CFMT) but uses eight different object categories. Principal component analysis reveals that the underlying structure of the VET can be largely explained by two independent factors, which demonstrate good reliability and capture interesting sex differences inherent in the VET structure. In Experiment 2, we show how the VET can be used to separate domain-specific from domain-general contributions to a standard measure of perceptual expertise. While domain-specific contributions are found for car matching for both men and women and for plane matching in men, women in this sample appear to use more domain-general strategies to match planes. In Experiment 3, we use the VET to demonstrate that holistic processing of faces predicts face recognition independently of general object recognition ability, which has a sex-specific contribution to face recognition. Overall, the results suggest that the VET is a reliable and valid measure of object recognition abilities and can measure both domain-general skills and domain-specific expertise, which were both found to depend on the sex of observers. PMID:22877929

  20. Evaluation of the specificity of an immunoprecipitin test for non-A, non-B hepatitis.

    PubMed

    Villarejos, V M; Visoná, K A; Serra, J

    1983-04-01

    The specificity of a new antigen-antibody system (devised at the International Center for Medical Research and Training [ICMRT], San José, Costa Rica) for non-A, non-B (NANB) hepatitis was evaluated. ICMRT antigen was found in eight (21%) of 38 patients with acute NANB hepatitis; 22 patients (58%) seroconverted, including three who were positive for ICMRT antigen. Five patients with chronic NANB hepatitis were persistently positive for ICMRT antigen and negative for ICMRT antibody during several years of observation. Neither ICMRT antigen nor seroconversion was found among 11 patients with hepatitis A and 19 with hepatitis B occurring concomitantly with NANB hepatitis; only two of 56 patients with other liver diseases had ICMRT antigen, both presumably with chronic antigenemia. Seven of 128 household contacts of patients with NANB hepatitis had ICMRT antigen; 27 had antibody initially, and 35 (37% of susceptible contacts) seroconverted during the observation period. Less than 4% of household contacts of patients with hepatitis A or B seroconverted. PMID:6404992

  1. The radiation dosimetry of intrathecally administered radionuclides

    SciTech Connect

    Stabin, M.G.; Evans, J.F.

    1999-01-01

    The radiation dose to the spine, spinal cord, marrow, and other organs of the body from intrathecal administration of several radiopharmaceuticals was studied. Anatomic models were developed for the spine, spinal cerebrospinal fluid (CSF), spinal cord, spinal skeleton, cranial skeleton, and cranial CSF. A kinetic model for the transport of CSF was used to determine residence times in the CSF; material leaving the CSF was thereafter assumed to enter the bloodstream and follow the kinetics of the radiopharmaceutical as if intravenously administered. The radiation transport codes MCNP and ALGAMP were used to model the electron and photon transport and energy deposition. The dosimetry of Tc-99m DTPA and HSA, In-111 DTPA, I-131 HSA, and Yb-169 DTPA was studied. Radiation dose profiles for the spinal cord and marrow in the spine were developed and average doses to all other organs were estimated, including dose distributions within the bone and marrow.

  2. REPRODUCIBILITY OF THE MODIFIED STAR EXCURSION BALANCE TEST COMPOSITE AND SPECIFIC REACH DIRECTION SCORES

    PubMed Central

    van Lieshout, Remko; Reijneveld, Elja A.E.; van den Berg, Sandra M.; Haerkens, Gijs M.; Koenders, Niek H.; de Leeuw, Arina J.; van Oorsouw, Roel G.; Paap, Davy; Scheffer, Else; Weterings, Stijn

    2016-01-01

    ABSTRACT Background The mSEBT is a screening tool used to evaluate dynamic balance. Most research investigating measurement properties focused on intrarater reliability and was done in small samples. To know whether the mSEBT is useful to discriminate dynamic balance between persons and to evaluate changes in dynamic balance, more research into intra- and interrater reliability and smallest detectable change (synonymous with minimal detectable change) is needed. Purpose To estimate intra- and interrater reliability and smallest detectable change of the mSEBT in adults at risk for ankle sprain. Study Design Cross-sectional, test-retest design Methods Fifty-five healthy young adults participating in sports at risk for ankle sprain participated (mean ± SD age, 24.0 ± 2.9 years). Each participant performed three test sessions within one hour and was rated by two physical therapists (session 1, rater 1; session 2, rater 2; session 3, rater 1). Participants and raters were blinded for previous measurements. Normalized composite and reach direction scores for the right and left leg were collected. Analysis of variance was used to calculate intraclass correlation coefficient values for intra- and interrater reliability. Smallest detectable change values were calculated based on the standard error of measurement. Results Intra- and interrater reliability for both legs was good to excellent (intraclass correlation coefficient ranging from 0.87 to 0.94). The intrarater smallest detectable change for the composite score of the right leg was 7.2% and for the left 6.2%. The interrater smallest detectable change for the composite score of the right leg was 6.9% and for the left 5.0%. Conclusion The mSEBT is a reliable measurement instrument to discriminate dynamic balance between persons. Most smallest detectable change values of the mSEBT appear to be large. More research is needed to investigate if the mSEBT is usable for evaluative purposes. Level of Evidence Level 2

  3. Using pathology-specific laboratory profiles in Clinical Pathology to reduce inappropriate test requesting: two completed audit cycles

    PubMed Central

    2012-01-01

    Background Systematic reviews have shown that, although well prepared, the Consensus Guidelines have failed to change clinical practice. In the healthcare district of Castelnovo né Monti (Reggio Emilia, Italy), it became necessary for the GPs and Clinical Pathologists to work together to jointly define laboratory profiles. Methods Observational study with two cycles of retrospective audit on test request forms, in a primary care setting. Objectives of the study were to develop pathology-specific laboratory profiles and to increase the number of provisional diagnoses on laboratory test request forms. A Multiprofessional Multidisciplinary Inter-hospital Work Team developed pathology-specific laboratory profiles for more effective test requesting. After 8 training sessions that used a combined strategy with multifaceted interventions, the 23 General Practitioners (GPs) in the trial district (Castelnovo nè Monti) tested the profiles; the 21 GPs in the Puianello district were the control group; all GPs in both districts participated in the trial. All laboratory tests for both healthcare districts are performed at the Laboratory located in the trial district. A baseline and a 1-year audit were performed in both districts on the GPs’ request forms. Results Seven pathology-specific laboratory profiles for outpatients were developed. In the year after the first audit cycle: 1) the number of tests requested in the trial district was distinctly lower than that in the previous year, with a decrease of about 5% (p < 0.001); 2) the provisional diagnosis on the request forms was 52.8% in the trial district and 42% in the control district (P < 0.001); 3) the decrease of the number of tests on each request form was much more marked in the trial district (8.73 vs. 10.77; p < 0.001). Conclusions The first audit cycle showed a significant decrease in the number of tests ordered only in the trial district. The combined strategy used in this study improved the

  4. Interictal regional cerebral blood flow during non specific activation test in partial epilepsy.

    PubMed Central

    Valmier, J; Touchon, J; Baldy-Moulinier, M

    1989-01-01

    In order to investigate, during activation testing, the interictal cortical cerebral blood flows (rCBF) of epileptic patients suffering from complex partial seizures, 40 epileptic patients (divided into "lesional", this is, with abnormal CT findings, and "non lesional", that is, with normal CT findings) were submitted to rCBF measurements with the 133 xenon intravenous technique, at rest and during intermittent light stimulation (ILS). The findings compared with normal volunteers seem to demonstrate that, during ILS, (1) in non lesional patients, the suspected epileptic focus shows a significant rCBF increase (2) in lesional patients, the significant rCBF increases were not in the region of the suspected epileptic focus but in adjacent or in contralateral ones. It was concluded that activation interictal rCBF measurements are more useful than resting ones for the determination of epileptic foci when CT findings are normal and that the nature of the epileptic focus influences markedly the interhemispheric activation pattern. PMID:2926422

  5. Test-specific effects of FG-7142 on isolation-induced aggression in mice.

    PubMed

    Rawleigh, J M; Kemble, E D

    1992-06-01

    Treatment with FG-7142 decreased isolation-induced attack, but not defense, by male mice when the residents' home cages contained only a sawdust substrate. When a small wooden nesting box was added to the cage (Experiment 2), however, FG-7142 somewhat increased levels of attack. Time spent in the nesting box was also increased, while overall levels of social interaction were decreased, by drug treatment in Experiment 2. The latter findings are consistent with FG-7142's well-documented anxiogenic properties and indicate that this drug is probably proaggressive in its actions. The antiaggressive effects of FG-7142 in Experiment 1 may have resulted from drug-induced fear behaviors that were incompatible with attack. Alternatively, Experiment 2 suggests the possibility that species-typical attack may be defensively motivated under some circumstances. Although the antiagressive properties of eltoprazine and yohimbine were unaffected by the addition of the nest box (Experiment 3), the provision of some sort of refuge within the testing apparatus may be an important methodological consideration for studies employing resident-intruder paradigms. PMID:1631186

  6. Immunoglobulin M-specific serologic testing in an outbreak of foodborne viral hepatitis, type A.

    PubMed

    Osterholm, M T; Kantor, R J; Bradley, D W; Hall, W N; Francis, D P; Aaron, H C; Washburn, J W; Velde, D

    1980-07-01

    Ninety-seven symptomatic and five asymptomatic infections with viral hepatitis, type A (102 cases) were identified in members, guests and employees of a private country club in an outbreak associated with consuming food and ice prepared or handled by an employee of the club's kitchen pantry. Twenty-three symptomatic persons were tested by differential radioimmunoassay for immunoglobulin M (IgM) (acute-phase) hepatitis A antibody (anti-HAV) and all 23 were documented to be infected with hepatitis A virus (HAV). Forty-one member/guest cases had only a single exposure at the county club. Their incubation periods ranged from 21 to 40 days, with a mean of 30 days. The exposure of these single-day patrons occurred over a 14-day period. The index case was not icteric and only moderately symptomatic and was diagnosed retrospectively to have viral hepatitis, type A by serologic determination of IgM anti-HAV in blood samples. Four items implicated in disease transmission were potato salad, hot dogs, molded salmon and ice handled by the index case. Serologic screening of controls did not appear to alter the conclusions of the food item analysis. PMID:6249120

  7. Minimizing the magnetic field effect in MR-linac specific QA-tests: the use of electron dense materials

    NASA Astrophysics Data System (ADS)

    van Zijp, H. M.; van Asselen, B.; Wolthaus, J. W. H.; Kok, J. M. G.; de Vries, J. H. W.; Ishakoglu, K.; Beld, E.; Lagendijk, J. J. W.; Raaymakers, B. W.

    2016-02-01

    To address the quality assurance (QA) of a MR-linac which is an MRI combined with a linear accelerator (linac), the traditional linac QA-tests need to be redesigned, since the presence of the static magnetic field in the MR-linac alters the electron trajectory. The latter causes the asymmetry in the dose kernel which is introduced by the magnetic field and hinders accurate geometrical QA-tests for the MR-linac. We introduced the use of electron dense materials (e.g. copper) to reduce the size of the dose kernel and thereby the magnetic field effect on the dose deposition. Two examples of QA-tests are presented in which the geometrical accuracy of the MR-linac was addressed; beam profile and star-shot measurements. The introduced setup was compared with a reference setup and both were tested on a conventional and the MR-linac. The results showed that the symmetry of the recorded beam profile was restored in presence of the copper material and that the isocenter size of the MR-linac can be determined accurately with the introduced star-shot setup. The use of electron dense materials is not limited to the presented QA-tests but has a broad application for beam-specific QA-tests in presence of a magnetic field.

  8. Technical basis for flawed cylinder test specification to assure adequate fracture resistance of ISO high-strength steel cylinder

    SciTech Connect

    Rana, M.D.; Smith, J.H.; Tribolet, R.O.

    1997-11-01

    High-pressure industrial gases (such as oxygen, nitrogen, argon, hydrogen, etc.) are stored and transported in portable cylinders. ISO TC58 SC3 has developed a draft specification 9809 for design and fabrication of high-pressure cylinders with maximum tensile strength limitation of 1,100 N/mm{sup 2}. In order to extend the ISO 9809 rules for higher than 1,100 N/mm{sup 2} strength level cylinders, a working group WG14 was formed in 1989 to develop new rules to assure adequate fracture resistance. In 1994, WG14 recommended a simple, but unique flawed cylinder test method for design qualification of the cylinder and acceptance criteria to assure adequate fracture resistance. WG14 also recommended Charpy-V-notch impact tests to control the required fracture resistance on production cylinders. This paper presents the technical basis that was employed in developing the flawed cylinder test method and acceptance criteria. The specification was developed for seamless steel cylinders having actual strength in the range of 1,100 to 1,400 N/mm{sup 2} and cylindrical section wall thickness in the range of 3 to 10 mm. Flawed cylinder tests were conducted on several hundred cylinders of varying sizes and strength levels. The specification requires to demonstrate LEAK-BEFORE-BREAK performance of the cylinder having flaw length equal to 1.6 (o.d. {times} t{sub design}){sup 0.5} at failure pressure = (t{sub design}/t{sub actual}) x Design Pressure.

  9. Web administered pre/post assessment: reliability, compliance and security

    NASA Astrophysics Data System (ADS)

    Bonham, Scott W.

    2006-12-01

    Pre/post assessment measures learning by comparing assessment performance before and after instruction. Usually it is administered on paper during class, needing to be distributed, collected, graded and analyzed. Administration on the web outside class frees up class time and automates many steps. However, this switch to unproctored web administration raises questions. Will the results be as reliable? Will students take it? Will test questions leak to fraternity files? An experiment using two different assessments pre/post test was carried out in introductory astronomy classes. Each section took one assessment on line and one in class. Comparing performance on paper vs. web provides information on reliability. Numbers of students completing in each mode give information on compliance and factors influencing it. Browser events that could indicate copying, saving or printing of questions were recorded to identify possible loss of security.

  10. The one repetition maximum test and the sit-to-stand test in the assessment of a specific pulmonary rehabilitation program on peripheral muscle strength in COPD patients

    PubMed Central

    Zanini, Andrea; Aiello, Marina; Cherubino, Francesca; Zampogna, Elisabetta; Azzola, Andrea; Chetta, Alfredo; Spanevello, Antonio

    2015-01-01

    Background Individuals with COPD may present reduced peripheral muscle strength, leading to impaired mobility. Comprehensive pulmonary rehabilitation (PR) should include strength training, in particular to lower limbs. Furthermore, simple tools for the assessment of peripheral muscle performance are required. Objectives To assess the peripheral muscle performance of COPD patients by the sit-to-stand test (STST), as compared to the one-repetition maximum (1-RM), considered as the gold standard for assessing muscle strength in non-laboratory situations, and to evaluate the responsiveness of STST to a PR program. Methods Sixty moderate-to-severe COPD inpatients were randomly included into either the specific strength training group or into the usual PR program group. Patients were assessed on a 30-second STST and 1-minute STST, 1-RM, and 6-minute walking test (6MWT), before and after PR. Bland–Altman plots were used to evaluate the agreement between 1-RM and STST. Results The two groups were not different at baseline. In all patients, 1-RM was significantly related to the 30-second STST (r=0.48, P<0.001) and to 1-minute STST (r=0.36, P=0.005). The 30-second STST was better tolerated in terms of the perceived fatigue (P=0.002) and less time consuming (P<0.001) test. In the specific strength training group significant improvements were observed in the 30-second STST (P<0.001), 1-minute STST (P=0.005), 1-RM (P<0.001), and in the 6MWT (P=0.001). In the usual PR program group, significant improvement was observed in the 30-second STST (P=0.042) and in the 6MWT (P=0.001). Conclusion Our study shows that in stable moderate-to-severe inpatients with COPD, STST is a valid and reliable tool to assess peripheral muscle performance of lower limbs, and is sensitive to a specific PR program. PMID:26648705

  11. Dose Dependence of the Anticoagulant Effect of Intravenously Administered Cellulose Sulfate.

    PubMed

    Drozd, N N; Kuznetsova, S A; Kalinina, T B; Vasilieva, N Yu

    2016-04-01

    Experiments on rabbits showed that increasing the dose of intravenously administered cellulose sulfate from wheat straw (dynamic viscosity 3.4 cP, sulfur content 14.1%) increased plasma clotting time in some coagulation tests and plasma anticoagulant activity. When cellulose sulfate was administered in the dose of 1 mg/kg, plasma clotting time in the presence of the anticoagulant (5 min after administration) was ~3-fold higher than after saline administration. PMID:27165079

  12. Racial/Ethnic-Specific Reference Intervals for Common Laboratory Tests: A Comparison among Asians, Blacks, Hispanics, and White

    PubMed Central

    Miyamura, Jill; Chen, John J

    2015-01-01

    Reference intervals (RIs) for common clinical laboratory tests are usually not developed separately for different subpopulations. The aim of this study was to investigate racial/ethnic differences in RIs of common biochemical and hematological laboratory tests using the National Health and Nutrition Examination Survey (NHANES) 2011–2012 data. This current study included 3,077 participants aged 18–65 years who reported their health status as “Excellent,” “Very good,” or “Good,” with known race/ethnicity as white, black, Hispanic, or Asian. Quantile regression analyses adjusted for sex were conducted to evaluate racial/ethnic differences in the normal ranges of 38 laboratory tests. Significant racial/ethnic differences were found in almost all laboratory tests. Compared to whites, the normal range for Asians significantly shifted to higher values in globulin and total protein and to lower values in creatinine, hematocrit, hemoglobin, mean cell hemoglobin, mean cell hemoglobin concentration, and mean platelet volume. These results indicate that racial/ethnic subpopulations have unique distributions in the labortoary tests and race/ethnicity may need to be incorporated in the development of their RIs. Establishment of racial/ethnic-specific RIs may have significant clinical and public health implication for more accurate disease diagnosis and appropriate treatment to improve quality of patient care, especially for a state with diverse racial/ethnic subpopuations such as Hawai‘i. PMID:26468426

  13. Diagnostic value of paraclinical tests in multiple sclerosis: relative sensitivities and specificities for reclassification according to the Poser committee criteria.

    PubMed Central

    Beer, S; Rösler, K M; Hess, C W

    1995-01-01

    The yield of paraclinical tests was evaluated in a prospective study of 189 consecutive patients referred for suspected multiple sclerosis (142 patients with multiple sclerosis, 47 non-multiple sclerosis patients on discharge). Patients were first classified according to the Poser criteria by the clinical findings. Subsequently, the results of paraclinical tests (cranial MRI, visually evoked potentials (VEPs), somatosensory evoked potentials by tibial nerve stimulation (SSEPs), motor evoked potentials (MEPs), and analysis of CSF for oligoclonal banding and IgG-index (CSF)) were taken into account. The percentage of reclassified patients (reclassification sensitivity, RS) was always lower than the percentage of abnormal results (diagnostic sensitivity, DS), and the divergence of RS v DS differed between the tests (60% v 84% in MRI, 31% v 77% in CSF, 29% v 37% in VEPs, 20% v 68% in MEPs, and 12% v 46% in SSEPs respectively). False reclassifications of non-multiple sclerosis patients to multiple sclerosis would have occurred with all tests (MRI: six of 47 patients, (reclassification specificity 88%); CSF: one (98%); VEPs: two (96%); MEPs: two (96%); SSEPs: four (91%); P < 0.05). Although MRI had superior diagnostic capacity, 57 of the 142 patients with multiple sclerosis were not reclassified by the MRI result, 12 of whom were reclassified by CSF and 18 by one of the evoked potential (EP) studies. Of the 98 patients not reclassified by CSF, 53 were reclassified by MRI and 39 by EPs. The results suggest that for the evaluation of paraclinical tests in suspected multiple sclerosis, comparison of diagnostic sensitivities is inappropriate. In general, a cranial MRI contributes most to the diagnosis; however, due to its comparatively low specificity and its considerable number of negative results, EP or CSF studies are often useful to establish the diagnosis of multiple sclerosis. PMID:7629529

  14. Sensitivity and specificity of an abbreviated 13C-mixed triglyceride breath test for measurement of pancreatic exocrine function

    PubMed Central

    Meier, Viola; Wolfram, Kristina U; Rosien, Ulrich; Layer, Peter

    2014-01-01

    Background A modified 13C-mixed triglyceride breath test (13C -MTGT) detects moderate pancreatic exocrine insufficiency noninvasively and reliably, but it requires prolonged breath sampling (6 hours (hr)). Objective We aimed to investigate whether 13C -MTGT can be abbreviated, to optimize clinical usability. Methods We analyzed the 13C-MTGT of 200 consecutive patients, retrospectively. Cumulative 1–5 hr 13C-exhalation values were compared with the standard parameter (6-hr cumulative 13C-exhalation). We determined the sensitivity and specificity of shortened breath sampling periods, by comparison with the normal values from 10 healthy volunteers, whom also underwent a secretin test to quantitate pancreatic secretion. Moreover, we evaluated the influence of gastric emptying (GE), using a 13C-octanoic acid breath test in a subset (N = 117). Results The 1–5 hr cumulative 13C-exhalation tests correlated highly and significantly with the standard parameter (p < 0.0001). Sensitivity for detection of impaired lipolysis was high (≥77%), but the specificity was low (≥38%) for the early measurements. Both parameters were high after 4 hrs (88% and 94%, respectively) and 5 hrs (98% and 91%, respectively). Multivariate linear correlation analysis confirmed that GE strongly influenced early postprandial 13C-exhalation during the 13C-MTGT. Conclusion Shortening of the 13C -MTGT from 6 to 4 hrs of duration was associated with similar diagnostic accuracy, yet increased clinical usability. The influence of GE on early postprandial results of the 13C-MTGT precluded further abbreviation of the test. PMID:25083286

  15. [Pharmacokinetics of cefatrizine administered in repeated doses].

    PubMed

    Couet, W; Reigner, B G; Lefebvre, M A; Bizouard, J; Fourtillan, J B

    1988-05-01

    Twelve healthy volunteers received cefatrizine orally at doses equal to 500 mg every 12 h for 5 days. Cefatrizine was assayed by high performance liquid chromatography in plasma and urines collected after the first and/or the last administration. Cefatrizine absorption was rapid; its peak plasma level was reached at time 1.79 +/- 0.07 h following the first dose, it was equal to 7.37 +/- 0.31 micrograms.ml-1. Its apparent elimination half-life was equal to 1.50 +/- 0.05 h, it explains the lack of accumulation with time during multiple administrations every 12 hours. Comparisons between peak plasma concentration and area under curves following the first and last dosing showed significant (p less than 0.01) but weak (close to 15%) reduction of these 2 parameters with time which could be explained by a slight reduction of cefatrizine absorption with time. In conclusion, cefatrizine does not accumulate when administered repeatedly at a dose equal to 500 mg every 12 h in young adult, and its pharmacokinetics is virtually linear with time. PMID:3043350

  16. 40 CFR 147.1700 - State-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false State-administered program. 147.1700 Section 147.1700 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS North Carolina § 147.1700 State-administered program. The...

  17. 40 CFR 147.2500 - State-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false State-administered program. 147.2500 Section 147.2500 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Wisconsin § 147.2500 State-administered program. The...

  18. 40 CFR 147.1450 - State-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false State-administered program. 147.1450 Section 147.1450 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Nevada § 147.1450 State-administered program. The UIC...

  19. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  20. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  1. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  2. 40 CFR 147.2351 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  3. 40 CFR 147.1651 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS New York § 147.1651 EPA-administered program. (a) Contents. The UIC program for the State of New York, including all Indian lands, is administered by EPA. The program consists of the UIC program requirements of 40...

  4. 40 CFR 147.1651 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS New York § 147.1651 EPA-administered program. (a) Contents. The UIC program for the State of New York, including all Indian lands, is administered by EPA. The program consists of the UIC program requirements of 40...

  5. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  6. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  7. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  8. 40 CFR 147.1201 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota § 147.1201 EPA-administered program. (a) Contents. The UIC program for the State of Minnesota is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148, and...

  9. 40 CFR 147.2751 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.2751... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS American Samoa §...

  10. 40 CFR 147.2701 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.2701... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virgin Islands §...

  11. 40 CFR 147.601 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.601... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Hawaii § 147.601...

  12. 40 CFR 147.1151 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.1151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Michigan §...

  13. 40 CFR 147.801 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Iowa § 147.801...

  14. 40 CFR 147.901 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.901... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Kentucky § 147.901...

  15. 40 CFR 147.2151 - EPA-administered program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Tennessee § 147.2151 EPA-administered program. (a) Contents. The UIC program for the State of Tennessee, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  16. 40 CFR 147.2151 - EPA-administered program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Tennessee § 147.2151 EPA-administered program. (a) Contents. The UIC program for the State of Tennessee, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  17. 40 CFR 147.2151 - EPA-administered program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Tennessee § 147.2151 EPA-administered program. (a) Contents. The UIC program for the State of Tennessee, including all Indian lands, is administered by EPA. This program consists of the UIC program requirements of 40...

  18. Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management.

    PubMed

    Yee, JoAnn L; Vanderford, Thomas H; Didier, Elizabeth S; Gray, Stanton; Lewis, Anne; Roberts, Jeffrey; Taylor, Kerry; Bohm, Rudolf P

    2016-04-01

    Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making. PMID:26932456

  19. Enhanced glucose tolerance by intravascularly administered piceatannol in freely moving healthy rats.

    PubMed

    Oritani, Yukihiro; Okitsu, Teru; Nishimura, Eisaku; Sai, Masahiko; Ito, Tatsuhiko; Takeuchi, Shoji

    2016-02-12

    Piceatannol is a phytochemical in the seeds of passion fruit that has a hypoglycemic effect when orally administered. To elucidate the contribution of intact and metabolites of piceatannol after gastro-intestinal absorption to hypoglycemic effect, we examined the influence of piceatannol and isorhapontigenin on blood glucose concentrations during fasting and glucose tolerance tests by administering them intravascularly to freely moving healthy rats. We found that intravascularly administered piceatannol reduced the blood glucose concentrations during both fasting and glucose tolerance tests, but isorhapontigenin did not during either of them. Furthermore, we found that piceatannol increased the insulinogenic index during glucose tolerance tests and that piceatannol had no influence on insulin sensitivity by performing hyperinsulinemic euglycemic clamping tests. These results suggest that piceatannol orally intaken may enhance glucose tolerance by the effect of intact piceatannol through enhanced early-phase secretion of insulin. Therefore, oral intake of piceatannol might contribute to proper control of postprandial glycemic excursions in healthy subjects. PMID:26773506

  20. Validation of a cognitive assessment battery administered by telephone

    PubMed Central

    Rapp, Stephen R.; Legault, Claudine; Espeland, Mark A.; Resnick, Susan M.; Hogan, Patricia E.; Coker, Laura H.; Dailey, Maggie; Shumaker, Sally A.

    2012-01-01

    Background While the gold standard method of cognitive assessment is a face-to-face administration, telephone-based assessments offer several advantages if they demonstrate reliability and validity. Design Observational study; 110 participants randomly assigned to receive two administrations of the same cognitive test battery 6 months apart in one of four combinations (1st administration/2nd administration): telephone/telephone; telephone/face-to-face; face-to-face/telephone; or face-to-face/face-to-face. Setting Academic medical center Participants 110 non-demented women between the ages of 65 and 90 years. Measures The battery included tests of attention, verbal learning and memory, verbal fluency, executive function, working memory and global cognitive functioning plus self-report measures of perceived memory problems, depressive symptoms, sleep disturbance and health-related quality of life. Test-retest reliability, concurrent validity, relative bias associated with telephone administration, and change scores were evaluated. Results There were no statistically significant differences in scores on any of the cognitive tests or questionnaires between randomly assigned modes of administration at baseline indicating equivalence across modes. There was no significant bias for tests or questionnaires administered by telephone (ps>0.01). Nor was there a difference in mean change scores between administration modes except for the Category Fluency (p = 0.01) and the California Verbal Learning Test long delay-free recall (p < 0.01). Mean test-retest coefficients for the battery were not significantly different across groups though individual test-retest correlation coefficients were generally higher within mode than across mode. Conclusions Telephone administration of cognitive tests and questionnaires to older women is both reliable and valid. Use of telephone batteries can substantially reduce the economic cost and burden of cognitive assessments and increase

  1. Type-specific HPV and Pap test results among low-income, underserved women: providing insights into management strategies

    PubMed Central

    Saraiya, Mona; Benard, Vicki B.; Greek, April A.; Steinau, Martin; Patel, Sonya; Massad, L. Stewart; Sawaya, George F.; Unger, Elizabeth R.

    2015-01-01

    OBJECTIVE The primary cervical cancer screening strategy for women over age 30 is high-risk human papillomavirus (HPV) testing combined with Papanicolaou (Pap) testing (cotesting) every 5 years. This combination strategy is a preventive service that is required by the Affordable Care Act to be covered with no cost-sharing by most health insurance plans. The cotesting recommendation was made based entirely on prospective data from an insured population that may have a lower proportion of women with HPV positive and Pap negative results (ie, discordant results). The discordant group represents a very difficult group to manage. If the frequency of discordant results among underserved women is higher, health care providers may perceive the cotesting strategy to be a less favorable screening strategy than traditional Pap testing every 3 years. STUDY DESIGN The Centers for Disease Control and Prevention’s Cervical Cancer Study was conducted at 15 clinics in 6 federally qualified health centers across Illinois. Providers at these clinics were given the option of cotesting for routine cervical cancer screening. Type-specific HPV detection was performed on residual extracts using linear array. RESULTS Pap test results were abnormal in 6.0% and HPV was positive in 7.2% of the underserved women screened in this study (mean age, 45.1 years). HPV prevalence decreased with age, from 10.3% among 30- to 39-year-olds to 4.5% among 50- to 60-year-olds. About 5% of the women had a combination of a positive HPV test and normal Pap test results; HPV 16/18 was identified in 14% of discordant women. CONCLUSION The rate of discordant results among underserved women was similar to those reported throughout the US in a variety of populations. Typing for HPV 16/18 appears to assist in the management in a small proportion of women with discordant results. PMID:24813971

  2. Interactions of conjugate vaccines and co-administered vaccines.

    PubMed

    Findlow, H; Borrow, R

    2016-01-01

    Conjugate vaccines play an important role in the prevention of infectious diseases such as those caused by the bacteria Haemophilus influenzae (Hi) type b (Hib), Neisseria meningitidis, and Streptococcus pneumoniae. Vaccines developed against these 3 pathogens utilize 3 main carrier proteins, non-toxic mutant of diphtheria toxin (CRM197), diphtheria toxoid (DT) and tetanus toxoid (TT). Current pediatric immunisation schedules include the administration of several vaccines simultaneously, therefore increasing the potential for immune interference (both positively and negatively) to the antigens administered. Knowledge of vaccine interactions is principally derived from clinical trials, these are reviewed here to explore immune interference which may result of from carrier-specific T-cell helper interactions, bystander interference and carrier induced epitopic suppression. PMID:26619353

  3. The Effectiveness of Time Management Directions and Assistance on Anagram Test Performance and State Anxiety.

    ERIC Educational Resources Information Center

    Hedl, John J., Jr.

    An anagram test administered under varying time parameters was used to evaluate the effectiveness of test-wiseness strategy. The relationship between test and state anxiety, and specific test-wiseness skills was explored. Students completed an anagram test in 15 or 25 minutes. Two groups received time-using directions and assistance during the…

  4. An Overview of Self-Administered Health Literacy Instruments

    PubMed Central

    O′Neill, Braden; Gonçalves, Daniela; Ricci-Cabello, Ignacio; Ziebland, Sue; Valderas, Jose

    2014-01-01

    With the increasing recognition of health literacy as a worldwide research priority, the development and refinement of indices to measure the construct is an important area of inquiry. Furthermore, the proliferation of online resources and research means that there is a growing need for self-administered instruments. We undertook a systematic overview to identify all published self-administered health literacy assessment indices to report their content and considerations associated with their administration. A primary aim of this study was to assist those seeking to employ a self-reported health literacy index to select one that has been developed and validated for an appropriate context, as well as with desired administration characteristics. Systematic searches were carried out in four electronic databases, and studies were included if they reported the development and/or validation of a novel health literacy assessment measure. Data were systematically extracted on key characteristics of the instruments: breadth of construct (“generic” vs. “content- or context- specific” health literacy), whether it was an original instrument or a derivative, country of origin, administration characteristics, age of target population (adult vs. pediatric), and evidence for validity. 35 articles met the inclusion criteria. There were 27 original instruments (27/35; 77.1%) and 8 derivative instruments (8/35; 22.9%). 22 indices measured “general” health literacy (22/35; 62.9%) while the remainder measured condition- or context- specific health literacy (13/35; 37.1%). Most health literacy measures were developed in the United States (22/35; 62.9%), and about half had adequate face, content, and construct validity (16/35; 45.7%). Given the number of measures available for many specific conditions and contexts, and that several have acceptable validity, our findings suggest that the research agenda should shift towards the investigation and elaboration of health literacy

  5. Targeted Lung Delivery of Nasally Administered Aerosols

    PubMed Central

    Tian, Geng; Hindle, Michael; Longest, P. Worth

    2014-01-01

    Using the nasal route to deliver pharmaceutical aerosols to the lungs has a number of advantages including co-administration during non-invasive ventilation. The objective of this study was to evaluate the growth and deposition characteristics of nasally administered aerosol throughout the conducting airways based on delivery with streamlined interfaces implementing two forms of controlled condensational growth technology. Characteristic conducting airways were considered including a nose-mouth-throat (NMT) geometry, complete upper tracheobronchial (TB) model through the third bifurcation (B3), and stochastic individual path (SIP) model to the terminal bronchioles (B15). Previously developed streamlined nasal cannula interfaces were used for the delivery of submicrometer particles using either enhanced condensational growth (ECG) or excipient enhanced growth (EEG) techniques. Computational fluid dynamics (CFD) simulations predicted aerosol transport, growth and deposition for a control (4.7 μm) and three submicrometer condensational aerosols with budesonide as a model insoluble drug. Depositional losses with condensational aerosols in the cannula and NMT were less than 5% of the initial dose, which represents an order-of-magnitude reduction compared to the control. The condensational growth techniques increased the TB dose by a factor of 1.1–2.6x, delivered at least 70% of the dose to the alveolar region, and produced final aerosol sizes ≥2.5 μm. Compared to multiple commercial orally inhaled products, the nose-to-lung delivery approach increased dose to the biologically important lower TB region by factors as large as 35x. In conclusion, nose-to-lung delivery with streamlined nasal cannulas and condensational aerosols was highly efficient and targeted deposition to the lower TB and alveolar regions. PMID:24932058

  6. Who Should Administer Energy-Efficiency Programs?

    SciTech Connect

    Blumstein, Carl; Goldman, Charles; Barbose, Galen L.

    2003-05-01

    The restructuring of the electric utility industry in the US created a crisis in the administration of ratepayer-funded energy-efficiency programs. Before restructuring, nearly all energy-efficiency programs in the US were administered by utilities and funded from utility rates. Restructuring called these arrangements into question in two ways. First, the separation of generation from transmission and distribution undermined a key rationale for utility administration. This was the Integrated Resource Planning approach in which the vertically integrated utility was given incentives to provide energy services at least cost. Second, questions were raised as to whether funding through utility rates could be sustained in a competitive environment and most states that restructured their electricity industry adopted a system benefits charge. The crisis in administration of energy-efficiency programs produced a variety of responses in the eight years since restructuring in the US began in earn est. These responses have included new rationales for energy-efficiency programs, new mechanisms for funding programs, and new mechanisms for program administration and governance. This paper focuses on issues related to program administration. It describes the administrative functions and some of the options for accomplishing them. Then it discusses criteria for choosing among the options. Examples are given that highlight some of the states that have made successful transitions to new governance and/or administration structures. Attention is also given to California where large-scale energy-efficiency programs have continued to operate, despite the fact that many of the key governance/administration issues remain unresolved. The conclusion attempts to summarize lessons learned.

  7. One-step 2-minute test to detect typhoid-specific antibodies based on particle separation in tubes.

    PubMed

    Lim, P L; Tam, F C; Cheong, Y M; Jegathesan, M

    1998-08-01

    Typhoid fever is caused by Salmonella typhi. Detection of anti-S. typhi antibodies in the patient is a useful diagnostic aid. Among the various methods developed over the years for this purpose, the Widal test, based on bacterial agglutination, has remained the most widely used, even though it is neither specific nor sensitive. Its popularity stems from the fact that it is simple to use and inexpensive. We describe a new test which also uses a simple one-step procedure but is more rapid and accurate than the Widal. The new test (TUBEX) detects anti-Salmonella O9 (both immunoglobulin M [IgM] and IgG) antibodies in patients by inhibiting the binding between an anti-O9 IgM monoclonal antibody (MAb) conjugated to colored latex particles and S. typhi lipopolysaccharide (LPS) conjugated to magnetic latex particles. The reactants are mixed in a specially designed microtube for 2 min, and the result is read based on the resultant color of the supernatant following forced sedimentation of the magnetic beads. In the absence of inhibitory antibodies, there is a color change (from blue to red) due to cosedimentation of the indicator particles with the magnetic particles, whereas if these antibodies are present, they prevent such a change to a degree dependent on their concentration. Preliminary examination of TUBEX using the anti-O9 MAb and irrelevant MAbs as inhibitors revealed the test to be specific and reproducible, with an analytical sensitivity of 16 micrograms per ml of antibody. The reagents remained stable for at least 9 months when kept at 4 degrees C. In the examination of 16 stored sera obtained from 14 patients with proven cases of typhoid fever and 78 serum samples from 75 subjects without typhoid fever, TUBEX was found to be 100% sensitive and 100% specific. The nontyphoid group comprised 26 healthy blood donors, 30 antinuclear antibody (ANA)-negative patients, 9 ANA-positive patients, of whom 1 was positive for anti-DNA antibody, 4 typhus patients, and 6

  8. Multiple testing in fMRI: an empirical case study on the balance between sensitivity, specificity, and stability.

    PubMed

    Durnez, Joke; Roels, Sanne P; Moerkerke, Beatrijs

    2014-07-01

    Functional Magnetic Resonance Imaging is a widespread technique in cognitive psychology that allows visualizing brain activation. The data analysis encompasses an enormous number of simultaneous statistical tests. Procedures that either control the familywise error rate or the false discovery rate have been applied to these data. These methods are mostly validated in terms of average sensitivity and specificity. However, procedures are not comparable if requirements on their error rates differ. Moreover, less attention has been given to the instability or variability of results. In a simulation study in the context of imaging, we first compare the Bonferroni and Benjamini-Hochberg procedures. Considering Bonferroni as a way to control the expected number of type I errors enables more lenient thresholding compared to familywise error rate control and a direct comparison between both procedures. We point out that while the same balance is obtained between average sensitivity and specificity, the Benjamini-Hochberg procedure appears less stable. Secondly, we have implemented the procedure of Gordon et al. () (originally proposed for gene selection) that includes stability, measured through bootstrapping, in the decision criterion. Simulations indicate that the method attains the same balance between sensitivity and specificity. It improves the stability of Benjamini-Hochberg but does not outperform Bonferroni, making this computationally heavy bootstrap procedure less appealing. Third, we show how stability of thresholding procedures can be assessed using real data. In a dataset on face recognition, we again find that Bonferroni renders more stable results. PMID:24804953

  9. Sensitivity and Specificity of a New Vertical Flow Rapid Diagnostic Test for the Serodiagnosis of Human Leptospirosis

    PubMed Central

    Goarant, Cyrille; Bourhy, Pascale; D'Ortenzio, Eric; Dartevelle, Sylvie; Mauron, Carine; Soupé-Gilbert, Marie-Estelle; Bruyère-Ostells, Lilian; Gourinat, Ann-Claire; Picardeau, Mathieu; Nato, Faridabano; Chanteau, Suzanne

    2013-01-01

    Background: Leptospirosis is a growing public health concern in many tropical and subtropical countries. However, its diagnosis is difficult because of non-specific symptoms and concurrent other endemic febrile diseases. In many regions, the laboratory diagnosis is not available due to a lack of preparedness and simple diagnostic assay or difficult access to reference laboratories. Yet, an early antibiotic treatment is decisive to the outcome. The need for Rapid Diagnostic Tests (RDTs) for bedside diagnosis of leptospirosis has been recognized. We developed a vertical flow immunochromatography strip RDT detecting anti-Leptospira human IgM and evaluated it in patients from New Caledonia, France, and French West Indies. Methodology/Principal Findings: Whole killed Leptospira fainei cells were used as antigen for the test line and purified human IgM as the control line. The mobile phase was made of gold particles conjugated with goat anti-human IgM. Standards for Reporting of Diagnostic Accuracy criteria were used to assess the performance of this RDT. The Microscopic Agglutination Test (MAT) was used as the gold standard with a cut-off titer of ≥400. The sensitivity was 89.8% and the specificity 93.7%. Positive and negative Likelihood Ratios of 14.18 and 0.108 respectively, and a Diagnostic Odds Ratio of 130.737 confirmed its usefulness. This RDT had satisfactory reproducibility, repeatability, thermal tolerance and shelf-life. The comparison with MAT evidenced the earliness of the RDT to detect seroconversion. When compared with other RDT, the Vertical Flow RDT developed displayed good diagnostic performances. Conclusions/Significance This RDT might be used as a point of care diagnostic tool in limited resources countries. An evaluation in field conditions and in other epidemiological contexts should be considered to assess its validity over a wider range of serogroups or when facing different endemic pathogens. It might prove useful in endemic contexts or

  10. Development of a POC Test for TB Based on Multiple Immunodominant Epitopes of M. tuberculosis Specific Cell-Wall Proteins

    PubMed Central

    Gonzalez, Jesus M.; Francis, Bryan; Burda, Sherri; Hess, Kaitlyn; Behera, Digamber; Gupta, Dheeraj; Agarwal, Ashutosh Nath; Verma, Indu; Verma, Ajoy; Myneedu, Vithal Prasad; Niedbala, Sam; Laal, Suman

    2014-01-01

    The need for an accurate, rapid, simple and affordable point-of-care (POC) test for Tuberculosis (TB) that can be implemented in microscopy centers and other peripheral health-care settings in the TB-endemic countries remains unmet. This manuscript describes preliminary results of a new prototype rapid lateral flow TB test based on detection of antibodies to immunodominant epitopes (peptides) derived from carefully selected, highly immunogenic M. tuberculosis cell-wall proteins. Peptide selection was initially based on recognition by antibodies in sera from TB patients but not in PPD-/PPD+/BCG-vaccinated individuals from TB-endemic settings. The peptides were conjugated to BSA; the purified peptide-BSA conjugates striped onto nitrocellulose membrane and adsorbed onto colloidal gold particles to devise the prototype test, and evaluated for reactivity with sera from 3 PPD-, 29 PPD+, 15 PPD-unknown healthy subjects, 10 patients with non-TB lung disease and 124 smear-positive TB patients. The assay parameters were adjusted to determine positive/negative status within 15 minutes via visual or instrumented assessment. There was minimal or no reactivity of sera from non-TB subjects with the striped BSA-peptides demonstrating the lack of anti-peptide antibodies in subjects with latent TB and/or BCG vaccination. Sera from most TB patients demonstrated reactivity with one or more peptides. The sensitivity of antibody detection ranged from 28–85% with the 9 BSA-peptides. Three peptides were further evaluated with sera from 400 subjects, including additional PPD-/PPD+/PPD-unknown healthy contacts, close hospital contacts and household contacts of untreated TB patients, patients with non-TB lung disease, and HIV+TB- patients. Combination of the 3 peptides provided sensitivity and specificity>90%. While the final fully optimized lateral flow POC test for TB is under development, these preliminary results demonstrate that an antibody-detection based rapid POC lateral flow test

  11. Rapid diagnostic tests as a source of DNA for Plasmodium species-specific real-time PCR

    PubMed Central

    2011-01-01

    Background This study describes the use of malaria rapid diagnostic tests (RDTs) as a source of DNA for Plasmodium species-specific real-time PCR. Methods First, the best method to recover DNA from RDTs was investigated and then the applicability of this DNA extraction method was assessed on 12 different RDT brands. Finally, two RDT brands (OptiMAL Rapid Malaria Test and SDFK60 malaria Ag Plasmodium falciparum/Pan test) were comprehensively evaluated on a panel of clinical samples submitted for routine malaria diagnosis at ITM. DNA amplification was done with the 18S rRNA real-time PCR targeting the four Plasmodium species. Results of PCR on RDT were compared to those obtained by PCR on whole blood samples. Results Best results were obtained by isolating DNA from the proximal part of the nitrocellulose component of the RDT strip with a simple DNA elution method. The PCR on RDT showed a detection limit of 0.02 asexual parasites/μl, which was identical to the same PCR on whole blood. For all 12 RDT brands tested, DNA was detected except for one brand when a low parasite density sample was applied. In RDTs with a plastic seal covering the nitrocellulose strip, DNA extraction was hampered. PCR analysis on clinical RDT samples demonstrated correct identification for single species infections for all RDT samples with asexual parasites of P. falciparum (n = 60), Plasmodium vivax (n = 10), Plasmodium ovale (n = 10) and Plasmodium malariae (n = 10). Samples with only gametocytes were detected in all OptiMAL and in 10 of the 11 SDFK60 tests. None of the negative samples (n = 20) gave a signal by PCR on RDT. With PCR on RDT, higher Ct-values were observed than with PCR on whole blood, with a mean difference of 2.68 for OptiMAL and 3.53 for SDFK60. Mixed infections were correctly identified with PCR on RDT in 4/5 OptiMAL tests and 2/5 SDFK60 tests. Conclusions RDTs are a reliable source of DNA for Plasmodium real-time PCR. This study demonstrates the best method of RDT

  12. A negative nontreponemal and/or specific antitreponemal IgM test does not exclude active infectious syphilis: evidence from a rabbit infectivity test

    PubMed Central

    Lin, Li-Rong; Tong, Man-Li; Gao, Kun; Zhu, Xiao-Zhen; Fan, Jin-Yi; Zheng, Wei-Hong; Li, Shu-Lian; Lin, Hui-Ling; Liu, Li-Li; Yang, Tian-Ci

    2016-01-01

    Abstract Background: The diagnostic criteria for active infectious syphilis in the clinic are important matter of controversy and debate. So far, clinicians habitually do use the negative results of the nontreponemal and/or the specific antitreponemal IgM as the evidences of disease-free or active infection-free status. Method: We present a case study involving a patient who was admitted to Zhongshan Hospital because of cerebral infarct. Clinical examination indicated he had a history of latent syphilis with negative nontreponemal and specific antitreponemal IgM tests. The cerebrospinal fluid sample from the patient was inoculated into seronegative New Zealand rabbit. Results: Motile Treponema pallidum was detected by a rabbit infectivity test in the patient's cerebrospinal fluid. This syphilis strain was confirmed by DNA subtyping form of “centers for disease control subtype/tp0548 sequence type”, and the strain type was 14d/f. Treatment with benzathine penicillin provided no apparent benefit, but treatment with aqueous crystalline penicillin G, especially recommended for neurosyphilis, led to disease regression. No evidence of cerebral infarct was observed during a 2-year follow-up period. Conclusion: The definitive differential diagnosis of active infectious syphilis should be reconsidered. Moreover, selecting the appropriate penicillin preparation is important because T pallidum can reside in sequestered sites. It is necessary to treat a patient with known invasion of the central nervous system with aqueous crystalline penicillin G, if previous treatment for syphilis failed and patients had some clinical neurological presentation that is otherwise unexplained, but that could represent neurosyphilis. Additional studies are needed to confirm the results in other syphilis patients. PMID:27495107

  13. 40 CFR Table C-4 to Subpart C of... - Test Specifications for PM10, PM2.5 and PM10-2.5 Candidate Equivalent Methods

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 6 2012-07-01 2012-07-01 false Test Specifications for PM10, PM2.5 and... Pt. 53, Subpt. C, Table C-4 Table C-4 to Subpart C of Part 53—Test Specifications for PM10, PM2.5 and PM10-2.5 Candidate Equivalent Methods Specification PM10 PM2.5 Class I Class II Class III...

  14. A Comparison of the Pencil-and-Paper and Computer-Administered Minnesota Multiphasic Personality Inventory-Adolescent

    ERIC Educational Resources Information Center

    Hays, Shannon; McCallum, R. Steve

    2005-01-01

    Within the context of a counterbalanced design, 102 students from either a high school or a large Southeastern university were administered two versions of the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A): a computer-administered version (CA) and a paper-and-pencil version (PAP). Time between testing sessions was approximately…

  15. Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn)

    SciTech Connect

    Theunissen, P.T.; Robinson, J.F.; Pennings, J.L.A.; Herwijnen, M.H. van; Kleinjans, J.C.S.; Piersma, A.H.

    2012-08-01

    Alternative assays for developmental toxicity testing are needed to reduce animal use in regulatory toxicology. The in vitro murine neural embryonic stem cell test (ESTn) was designed as an alternative for neurodevelopmental toxicity testing. The integration of toxicogenomic-based approaches may further increase predictivity as well as provide insight into underlying mechanisms of developmental toxicity. In the present study, we investigated concentration-dependent effects of six mechanistically diverse compounds, acetaldehyde (ACE), carbamazepine (CBZ), flusilazole (FLU), monoethylhexyl phthalate (MEHP), penicillin G (PENG) and phenytoin (PHE), on the transcriptome and neural differentiation in the ESTn. All compounds with the exception of PENG altered ESTn morphology (cytotoxicity and neural differentiation) in a concentration-dependent manner. Compound induced gene expression changes and corresponding enriched gene ontology biological processes (GO–BP) were identified after 24 h exposure at equipotent differentiation-inhibiting concentrations of the compounds. Both compound-specific and common gene expression changes were observed between subsets of tested compounds, in terms of significance, magnitude of regulation and functionality. For example, ACE, CBZ and FLU induced robust changes in number of significantly altered genes (≥ 687 genes) as well as a variety of GO–BP, as compared to MEHP, PHE and PENG (≤ 55 genes with no significant changes in GO–BP observed). Genes associated with developmentally related processes (embryonic morphogenesis, neuron differentiation, and Wnt signaling) showed diverse regulation after exposure to ACE, CBZ and FLU. In addition, gene expression and GO–BP enrichment showed concentration dependence, allowing discrimination of non-toxic versus toxic concentrations on the basis of transcriptomics. This information may be used to define adaptive versus toxic responses at the transcriptome level.

  16. Species-specific considerations in using the fish embryo test as an alternative to identify endocrine disruption.

    PubMed

    Schiller, Viktoria; Zhang, Xiaowei; Hecker, Markus; Schäfers, Christoph; Fischer, Rainer; Fenske, Martina

    2014-10-01

    A number of regulations have been implemented that aim to control the release of potentially adverse endocrine disrupters into the aquatic environment based on evidence from laboratory studies. Currently, such studies rely on testing approaches with adult fish because reliable alternatives have not been validated so far. Fish embryo tests have been proposed as such an alternative, and here we compared two species (medaka and zebrafish) to determine their suitability for the assessment of substances with estrogenic and anti-androgenic activity. Changes in gene expression (in here the phrase gene expression is used synonymously to gene transcription, although it is acknowledged that gene expression is additionally regulated, e.g., by translation and protein stability) patterns between the two species were compared in short term embryo exposure tests (medaka: 7-day post fertilization [dpf]; zebrafish: 48 and 96h post fertilization [hpf]) by using relative quantitative real-time RT-PCR. The tested genes were related to the hypothalamic-gonadal-axis and early steroidogenesis. Test chemicals included 17α-ethinylestradiol and flutamide as estrogenic and anti-androgenic reference compounds, respectively, as well as five additional substances with endocrine activities, namely bisphenol A, genistein, prochloraz, linuron and propanil. Estrogenic responses were comparable in 7-dpf medaka and 48/96-hpf zebrafish embryos and included transcriptional upregulation of aromatase b, vitellogenin 1 as well as steroidogenic genes, suggesting that both species reliably detected exposure to estrogenic compounds. However, anti-androgenic responses differed between the two species, with each species providing specific information concerning the mechanism of anti-androgenic disruption in fish embryos. Although small but significant changes in the expression of selected genes was observed in 48-hpf zebrafish embryos, exposure prolonged to 96hpf was necessary to obtain a response indicative

  17. Creating a lesson that addresses gender differences in physics testing a specific instructional technique in college level physics education

    NASA Astrophysics Data System (ADS)

    Lincoln, James J.

    Research-based instructional methods are applied in an effort to close the persistent gender gap in physics. Creating a short text on a limited topic using some of these methods could benefit female students specifically. A literature review showed research on the gender gap in physics and updated instructional methods for females. Two female physics students were interviewed and observations were conducted at a high performing all-girls school. A physics lab dialogue between two female physics students was recorded and analyzed, which informed the style and voice of the interactive dialogue lesson. An original written lesson intended to engage female physics students was created and tested on three classes of college-level physics students. The survey data, based on multiple choice and essay responses, measured the students' opinions of the lesson and their current textbook. Results showed the interactive lesson was preferred over the current text, and some students requested similar lessons.

  18. Project W-314 specific test and evaluation plan for transfer line SN-633 (241-AX-B to 241-AY-02A)

    SciTech Connect

    Hays, W.H.

    1998-03-20

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made by the addition of the SN-633 transfer line by the W-314 Project. The STEP develops the outline for test procedures that verify the system`s performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the addition of transfer line SN-633. The Project Design Specifications (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation.

  19. An Efficient Stepwise Statistical Test to Identify Multiple Linked Human Genetic Variants Associated with Specific Phenotypic Traits

    PubMed Central

    Huh, Iksoo; Kwon, Min-Seok; Park, Taesung

    2015-01-01

    Recent advances in genotyping methodologies have allowed genome-wide association studies (GWAS) to accurately identify genetic variants that associate with common or pathological complex traits. Although most GWAS have focused on associations with single genetic variants, joint identification of multiple genetic variants, and how they interact, is essential for understanding the genetic architecture of complex phenotypic traits. Here, we propose an efficient stepwise method based on the Cochran-Mantel-Haenszel test (for stratified categorical data) to identify causal joint multiple genetic variants in GWAS. This method combines the CMH statistic with a stepwise procedure to detect multiple genetic variants associated with specific categorical traits, using a series of associated I × J contingency tables and a null hypothesis of no phenotype association. Through a new stratification scheme based on the sum of minor allele count criteria, we make the method more feasible for GWAS data having sample sizes of several thousands. We also examine the properties of the proposed stepwise method via simulation studies, and show that the stepwise CMH test performs better than other existing methods (e.g., logistic regression and detection of associations by Markov blanket) for identifying multiple genetic variants. Finally, we apply the proposed approach to two genomic sequencing datasets to detect linked genetic variants associated with bipolar disorder and obesity, respectively. PMID:26406920

  20. Chlamydia trachomatis Infection in HIV-Infected Women: Need for Screening by a Sensitive and Specific Test

    PubMed Central

    Bhattar, Sonali; Chadha, Sanjim; Tripathi, Reva; Kaur, Ravinder; Sardana, Kabir

    2013-01-01

    Reproductive tract infection (RTIs)/sexually transmitted infections (STIs) are recognized as a major public health problem, particularly due to their relationship with HIV infection. Early detection and treatment of Chlamydia trachomatis infection (CTI) among HIV-infected and HIV-uninfected women may impact heterosexual HIV transmission. A total of 120 participants were enrolled: 30 HIV seropositive women with symptoms of RTIs, 30 HIV seropositive women without symptoms of RTIs, 30 HIV seronegative women with symptoms of RTIs, and 30 HIV seronegative women without symptoms of RTIs. One endocervical swab was collected from all participants and CTI was detected by real-time PCR (COBAS TaqMan CT Test, v2.0). CTI was detected in 4 (6.67%) HIV-infected women and in 1 (1.67%) HIV-uninfected woman (OR 4.214; 95% CI 0.457–38.865). Vaginal discharge was present in almost half of HIV-infected and HIV-uninfected women; lower abdominal pain was present in 11 (18.3%) of HIV-infected and in 9 (15%) of HIV-uninfected women. This study showed that CTI is more prevalent among HIV-infected females as compared to HIV-uninfected females. As the use of real-time PCR is not feasible in most hospitals, efforts should be made to develop a simple, sensitive, and specific test to identify women with CTI for prevention of sequelae and HIV transmission. PMID:24382941

  1. [Usefulness of endotoxin-specific limulus test for the measurement of endotoxin in cerebrospinal fluid in diagnosis of bacterial meningitis].

    PubMed

    Ichinohe, S; Inada, K; Nemoto, T; Murata, A; Ichinohe, N; Fujiwara, T; Yoshida, M

    1995-11-01

    Using a new endotoxin-specific chromogneic limulus assay (Endoscopy test), endotoxin concentrations were measured in 93 specimens of cerebrospinal fluid (CSF) from 66 pediatric patients. Eighteen patients were diagnosed as having menigitios. Of these, 6 cases (group A) with gram-negative meningitis proven by culture had high CSF endotoxin concentrations of 115.3, (82-133) (median, range) pg/ml. Ten cases (group B) with gram-positive or aseptic meningitis had endotoxin concentrations of 2.15 (0.1-3.6) pg ml. Other 2 cases with bacterial meningitis (group C), in whom no pathogen was detected, had CSF endotoxin concentrations of more than 100 pg/ml. Four cases with encephalitis (group D) and 45 cases with non-meningitis or non- encephalitis (group E), had CSF endotoxin concentrations of less than 5 pg/ml. Despite a negative culture after antibiotic treatment in group A patients, endotoxin was cleared slowly from the CSF. A clearing of endotoxin from CSF was followed by alleviation of fever with a more gradual decline in CRP values. In 2 cases of group C, the negative bacterial culture appeared to be attributable to the previous treatment with antibiotics. However, these patients had high CSF endotoxin levels, indicating gram negative bacterial meningitis. In 17 CSF specimens from 5 patients of group A, in whom Haemophilus influenzae was detected on admission, an additional a latex agglutination test for the detection of H. influenzae polysaccharide antigen was performed. Only 3 specimens from 3 patients with CSF endotoxin concentrations of more than 80 pg/ml had a positive agglutination test. These results suggest that quantitation of endotoxin concentrations is useful for the diagnosis of gram-negative meningitis. And also, the clearance of endotoxin from CSF during treatment appears to be useful in determining the timing of when antibiotic should be stopped. PMID:8708402

  2. The TUBEX test detects not only typhoid-specific antibodies but also soluble antigens and whole bacteria.

    PubMed

    Tam, Frankie C H; Ling, Thomas K W; Wong, Kam Tak; Leung, Danny T M; Chan, Raphael C Y; Lim, Pak Leong

    2008-03-01

    TUBEX (IDL Biotech) is a 5 min semiquantitative colorimetric test for typhoid fever, a widely endemic disease. TUBEX detects anti-Salmonella O9 antibodies from a patient's serum by the ability of these antibodies to inhibit the binding between an indicator antibody-bound particle and a magnetic antigen-bound particle. Herein, we report that TUBEX could also be used to specifically detect soluble O9 lipopolysaccharide in antigen-spiked buffer by the ability of the antigen to inhibit the same binding between the particles. Sensitivity of antigen detection was improved (8-31 mug ml(-1)) by using a modified protocol in which the test sample was mixed with the indicator particles first, rather than with the magnetic particles as for antibody detection. The antigen was also detectable in spiked serum and urine samples, albeit less well (2-4-fold) than in buffer generally. However, no antigen was detected from six typhoid sera examined, all of which had anti-O9 antibodies. In addition, whole organisms of Salmonella Typhi (15 strains) and Salmonella Enteritidis (6 strains) (both O9(+) Salmonella), grown in simulated blood broths or on MacConkey agar, were also detectable by TUBEX when suspended at >9 x 10(8) organisms ml(-1). Expectedly, Salmonella Paratyphi A (7 strains), Salmonella Typhimurium (1 strain) and Escherichia coli (2 strains) were negative in the test. Thus, the same TUBEX kit may be used in several ways both serologically and microbiologically for the rapid diagnosis of typhoid fever. However, validation of the newer applications will require the systematic examination of real patient and laboratory materials. PMID:18287294

  3. Latex agglutination using the periplasmic proteins antigen of Brucella melitensis is a successful, rapid, and specific serodiagnostic test for ovine brucellosis.

    PubMed

    Ismael, Alaa Bassuny; Swelum, Ayman Abdel-Aziz; Mostafa, Salama A-H; Alhumiany, Abdel-Rahman A

    2016-09-01

    Brucellosis, especially caused by Brucella melitensis, is considered the most-widespread zoonosis in the world, particularly in developing countries. This study was planned to develop an accurate test for diagnosis of ovine brucellosis using a specific hot saline extracted soluble Brucella melitensis periplasmic proteins (SBPPs). The efficacy of the latex agglutination test (LAT) using SBPPs compared to the Rose Bengal test (RBT), buffered plate agglutination test (BPAT), serum agglutination test (SAT), and an indirect enzyme-linked immunosorbent assay (i-ELISA) was evaluated in the field diagnosis of ovine brucellosis. The test performance was evaluated by estimating sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), disease prevalence (DP), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) using test agreement and bacteriological culture in 1777 samples. The false-positive result was significantly (P ⩽0.05) lower in LAT than RBT, BPAT, SAT, and i-ELISA. With reference to test agreement, the Se, Sp, PPV, and PLR were highest (P ⩽0.05) in LAT 99.33%, 99.88%, 98.68%, and 827.25%, respectively. With reference to bacteriological culture, the LAT and i-ELISA tests showed a significant difference in Se with SAT. However, no significant difference in specificity was detected. The DP was 8.44% in the five tests. In conclusion, LAT using SBPPs of B. melitensis could be a suitable serodiagnostic field test for ovine brucellosis, with high sensitivity and specificity. PMID:27207442

  4. 43 CFR 420.25 - Reclamation lands administered by other agencies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for management of Reclamation lands for recreation purposes. Specifically: (1) Reclamation lands managed by the National Park Service, the Bureau of Sport Fisheries and Wildlife, the Bureau of Land Management, the Forest Service, and other Federal agencies will be administered in accordance...

  5. Development of a simple and rapid diagnosis method for swine edema disease to specifically detect Stx2e protein by immunochromatographic test.

    PubMed

    Arimitsu, Hideyuki; Sasaki, Keiko; Tsuji, Takao

    2016-05-01

    Edema disease in piglets is caused by Shiga toxin 2e (Stx2e)-producing Escherichia coli. However, there is currently no available Stx2e-specific immunochromatographic test strip to differentiate Stx2e from other types of Shiga toxin 2. In the present study, to develop an Stx2e-specific immunochromatographic test strip, we isolated nine different monoclonal antibody-producing hybridoma clones from Stx2e toxoid-immunized mice and confirmed that six antibodies were A subunit-specific whereas three antibodies were B subunit-specific. Only one A subunit-specific monoclonal antibody (45B2) was cross-reactive with prototype Stx2 (Stx2a) at the same sensitivity, but the remaining eight monoclonal antibodies were not. In immunochromatographic tests using the highly sensitive antibodies, test strips using some combinations of gold colloid-conjugated monoclonal antibody with the B subunit-specific monoclonal antibody on the membrane detected Stx2e, but not other types of Shiga toxin 2. These test strips had the ability to detect Stx2e in the culture supernatant of clinically isolated Stx2e gene-positive strains, but not in those of Stx2e gene-negative strains. These results indicate that our test strip is practical for the specific detection of Stx2e to diagnose swine edema disease. PMID:26996467

  6. From regional to site specific SPTHA through inundation simulations: a case study for three test sites in Central Mediterranean

    NASA Astrophysics Data System (ADS)

    Selva, Jacopo; Tonini, Roberto; Romano, Fabrizio; Volpe, Manuela; Brizuela, Beatriz; Piatanesi, Alessio; Basili, Roberto; Lorito, Stefano

    2016-04-01

    We propose a procedure that enables the quantification of tsunami hazard at specific target sites through numerical simulations, accounting for the full variability of potential seismic sources. To this end, we developed a method that reduces the computational effort required by a very large number of detailed inundation simulations by adopting the offshore tsunami propagation patterns used for regional Seismic PTHA (SPTHA) as a proxy for the subsequent hazard estimate. The reduction of the computational effort is based on a two steps filtering procedure of the offshore SPTHA, through which a reduced number of scenarios to be modelled for inundation is selected. Each scenario represents a larger set of sources that form a cluster of potential tsunamis with similar impact on the target area. This filtering procedure is completely based on the tsunami profiles offshore, and it represents a generalization of the method proposed in Lorito et al. (2015) allowing i) to consider a much larger set of input linear simulations, and ii) to control the within-cluster variance of each selected cluster of seismic sources (thence, indirectly the artificial uncertainty introduced in probabilistic inundation maps by this filtering process). Here we present the preliminary results obtained for three test sites in central Mediterranean (Milazzo and Siracusa, Southern Italy, and Thessaloniki, Northern Greece). We preliminary perform a regional SPTHA covering the whole Mediterranean, in which the aleatory variability is quantified considering about 2 × 107 different seismic sources, and epistemic uncertainty is explored through an ensemble model based on more than ×105 alternative model implementations. For each site, separately, few hundreds of "representative scenarios" are filtered out of all the potential seismic sources. Then, the inundations caused by such scenarios is explicitly modelled and the site-specific SPTHA obtained, allowing a complete characterization of the tsunami

  7. Sensitivity and Specificity of a Urine Circulating Anodic Antigen Test for the Diagnosis of Schistosoma haematobium in Low Endemic Settings

    PubMed Central

    Knopp, Stefanie; Corstjens, Paul L. A. M.; Koukounari, Artemis; Cercamondi, Colin I.; Ame, Shaali M.; Ali, Said M.; de Dood, Claudia J.; Mohammed, Khalfan A.; Utzinger, Jürg; Rollinson, David; van Dam, Govert J.

    2015-01-01

    Background Elimination of schistosomiasis as a public health problem and interruption of transmission in selected areas are key goals of the World Health Organization for 2025. Conventional parasitological methods are insensitive for the detection of light-intensity infections. Techniques with high sensitivity and specificity are required for an accurate diagnosis in low-transmission settings and verification of elimination. We determined the accuracy of a urine-based up-converting phosphor-lateral flow circulating anodic antigen (UCP-LF CAA) assay for Schistosoma haematobium diagnosis in low-prevalence settings in Zanzibar, Tanzania. Methodology A total of 1,740 urine samples were collected in 2013 from children on Pemba Island, from schools where the S. haematobium prevalence was <2%, 2–5%, and 5–10%, based on a single urine filtration. On the day of collection, all samples were tested for microhematuria with reagent strips and for the presence of S. haematobium eggs with microscopy. Eight months later, 1.5 ml of urine from each of 1,200 samples stored at -20°C were analyzed by UCP-LF CAA assay, while urine filtration slides were subjected to quality control (QCUF). In the absence of a true ‘gold’ standard, the diagnostic performance was calculated using latent class analyses (LCA). Principal Findings The ‘empirical’ S. haematobium prevalence revealed by UCP-LF CAA, QCUF, and reagent strips was 14%, 5%, and 4%, respectively. LCA revealed a sensitivity of the UCP-LF CAA, QCUF, and reagent strips of 97% (95% confidence interval (CI): 91–100%), 86% (95% CI: 72–99%), and 67% (95% CI: 52–81%), respectively. Test specificities were consistently above 90%. Conclusions/Significance The UCP-LF CAA assay shows high sensitivity for the diagnosis of S. haematobium in low-endemicity settings. Empirically, it detects a considerably higher number of infections than microscopy. Hence, the UCP-LF CAA employed in combination with QCUF, is a promising tool for

  8. Testing the McSad depression specific classification system in patients with somatic conditions: validity and performance

    PubMed Central

    2013-01-01

    Background Valuations of depression are useful to evaluate depression interventions offered to patients with chronic somatic conditions. The only classification system to describe depression developed specifically for valuation purposes is the McSad, but it has not been used among somatic patients. The aim of this study was to test the construct validity of the McSad among diabetes and cancer patients and then to compare the McSad to the commonly used EuroQol – 5 Dimensions (EQ-5DTM) classification system. The comparison was expected to shed light on their capacity to reflect the range of depression states experienced by somatic patients. Methods Cross-sectional data were collected online from 114 diabetes and 195 cancer patients; additionally, 241 cancer patients completed part of the survey on paper. Correlational analyses were performed to test the construct validity. Specifically, we hypothesized high correlations of the McSad domains with depression (Center for Epidemiological Studies Depression Scale (CES-D) and the Patient Health Questionnaire (PHQ-9)). We also expected low/moderate correlations with self-esteem (Rosenberg Self-Esteem scale - RSE) and extraversion (Eysenck Personality Questionnaire Extraversion scale - EPQ-e). Multiple linear regression analyses were run so that the proportion of variance in depression scores (CES-D, PHQ-9) explained by the McSad could be compared to the proportion explained by the EQ-5D classification system. Results As expected, among all patients groups, we found moderate to high correlations for the McSad domains with the CES-D (.41 to .70) and the PHQ-9 (.52 to .76); we also found low to moderate correlations with the RSE (-.21 to .-48) and the EPQ-e (.18 to .31). Linear regression analyses showed that the McSad explained a greater proportion of variance in depression (CES-D, PHQ-9) (Diabetes: 73%, 82%; Cancer: 72%, 72%) than the EQ-5D classification system (Diabetes: 47%, 59%; Cancer: 51%, 47%). Conclusions Findings

  9. Biology, host specificity tests, and risk assessment of the sawfly Heteroperreyia hubrichi, a potential biological control agent of Schinus terebinthifolius in Hawaii

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Abstract. Heteroperreyia hubrichi Malaise (Hymenoptera: Pergidae), a foliage feeding sawfly of Schinus terebinthifolius Raddi (Sapindales: Anacardiaceae), was studied to assess its suitability as a classical biological control agent of this invasive weed in Hawaii. Nochoice host-specificity tests we...

  10. 40 CFR 282.56 - Connecticut State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Connecticut State-Administered Program. 282.56 Section 282.56 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.56 Connecticut State-Administered Program. (a) The...

  11. 40 CFR 282.56 - Connecticut State-Administered Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Connecticut State-Administered Program. 282.56 Section 282.56 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.56 Connecticut State-Administered Program. (a) The...

  12. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SERVICES AMATEUR RADIO SERVICE Qualifying Examination Systems § 97.509 Administering VE requirements. (a) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... person who holds an amateur operator license of the class specified below: (i) Amateur Extra, Advanced...

  13. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SERVICES AMATEUR RADIO SERVICE Qualifying Examination Systems § 97.509 Administering VE requirements. (a) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... person who holds an amateur operator license of the class specified below: (i) Amateur Extra, Advanced...

  14. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES AMATEUR RADIO SERVICE Qualifying Examination Systems § 97.509 Administering VE requirements. (a) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... person who holds an amateur operator license of the class specified below: (i) Amateur Extra, Advanced...

  15. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SERVICES AMATEUR RADIO SERVICE Qualifying Examination Systems § 97.509 Administering VE requirements. (a) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... person who holds an amateur operator license of the class specified below: (i) Amateur Extra, Advanced...

  16. 47 CFR 97.509 - Administering VE requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SERVICES AMATEUR RADIO SERVICE Qualifying Examination Systems § 97.509 Administering VE requirements. (a) Each examination for an amateur operator license must be administered by a team of at least 3 VEs at an... person who holds an amateur operator license of the class specified below: (i) Amateur Extra, Advanced...

  17. 40 CFR 282.66 - Kansas State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Kansas State-Administered Program. 282.66 Section 282.66 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.66 Kansas State-Administered Program. (a) The State of...

  18. 40 CFR 282.88 - Pennsylvania State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Pennsylvania State-Administered Program. 282.88 Section 282.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.88 Pennsylvania State-Administered Program. (a)...

  19. 40 CFR 282.96 - Virginia State-Administered Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Virginia State-Administered Program. 282.96 Section 282.96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED UNDERGROUND STORAGE TANK PROGRAMS Approved State Programs § 282.96 Virginia State-Administered Program. (a) The State...

  20. 40 CFR 147.2350 - State-administered program. [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false State-administered program. 147.2350 Section 147.2350 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia §...