Science.gov

Sample records for administration bpa proposes

  1. Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration.

    PubMed

    Draganov, Dragomir I; Markham, Dan A; Beyer, Dieter; Waechter, John M; Dimond, Stephen S; Budinsky, Robert A; Shiotsuka, Ronald N; Snyder, Stephanie A; Ehman, Kimberly D; Hentges, Steven G

    2015-07-01

    Orally administered bisphenol A (BPA) undergoes efficient first-pass metabolism to produce the inactive conjugates BPA-glucuronide (BPA-G) and BPA-sulfate (BPA-S). This study was conducted to evaluate the pharmacokinetics of BPA, BPA-G and BPA-S in neonatal mice following the administration of a single oral or subcutaneous (SC) dose. This study consisted of 3 phases: (1) mass-balance phase in which effective dose delivery procedures for oral or SC administration of (3)H-BPA to postnatal day three (PND3) mice were developed; (2) pharmacokinetic phase during which systemic exposure to total (3)H-BPA-derived radioactivity in female PND3 mice was established; and (3) metabolite profiling phase in which 50 female PND3 pups received either a single oral or SC dose of (3)H-BPA. Blood was collected from 5 pups/route/time-point at various times post-dosing, the blood plasma samples were pooled by group, and time-point and samples were profiled by HPLC with fraction collection. Fractions were analyzed for total radioactivity and data used to reconstruct radiochromatograms and to integrate individual peaks. The identity of the BPA, BPA-G, and BPA-S peaks was confirmed using authentic standards and LC-MS/MS analysis. The result of this study revealed that female PND3 mice have the capacity to metabolize BPA to BPA-G, BPA-S and other metabolites after both routes of administration. Systemic exposure to free BPA is route-dependent as the plasma concentrations were lower following oral administration compared to SC injection. PMID:25929835

  2. BPA Statutes.

    SciTech Connect

    United States. Bonneville Power Administration.

    1999-08-01

    This report contains the Bonneville Power Administration's (BPA's) authorizing statutes--the Bonneville Project Act, the Federal Columbia River Transmission System Act, the Pacific Northwest Electric Power Planning and Conservation Act and other laws that contain provisions that define BPA's mission and affect the way it is carried out.

  3. The Administration's Private Pension Proposal.

    ERIC Educational Resources Information Center

    American Enterprise Inst. for Public Policy Research, Washington, DC.

    This report examines legislation proposed by the Nixon administration to (1) make available to employed workers a new type of personal retirement plan having tax-deferral advantages, (2) apply pre-retirement vesting requirements to the private pension system, and (3) broaden tax-deferred retirement plans presently available to the self-employed…

  4. BPA Facts

    SciTech Connect

    2014-03-01

    The Bonneville Power Administration is a federal nonprofit power marketing administration based in the Pacific Northwest . Although BPA is part of the U .S . Department of Energy, it is self-funding and covers its costs by selling its products and services . BPA markets wholesale electrical power from 31 federal hydro projects in the Columbia River Basin, one nonfederal nuclear plant and several small nonfederal power plants . The dams are operated by the U .S . Army Corps of Engineers and the Bureau of Reclamation . About 30 percent of the electric power used in the Northwest comes from BPA . BPA’s resources — primarily hydroelectric — make its power nearly carbon free . BPA also operates and maintains about three- fourths of the high-voltage transmission in its service territory . BPA’s service territory includes Idaho, Oregon, Washington, western Montana and small parts of eastern Montana, California, Nevada, Utah and Wyoming . BPA promotes energy efficiency, renewable resources and new technologies that improve its ability to deliver on its mission . BPA also funds regional efforts to protect and enhance fish and wildlife populations affected by hydropower development in the Columbia River Basin . BPA is committed to public service and seeks to make its decisions in a manner that provides opportunities for input from stakeholders . In its vision statement, BPA dedicates itself to providing high system reliability, low rates consistent with sound business principles, environmental stewardship and accountability

  5. Proposed Revenues, Financial Strategy, and Program Costs for FY 1992 and 1993 : Technical Appendix, BPA Programs in Perspective.

    SciTech Connect

    United States. Bonneville Power Administration.

    1990-07-01

    Programs in Perspective is the Bonneville Power Administration's public involvement process (PIP) for engaging customers and other stakeholders in a regional dialog to set strategic direction and broad program plans for BPA effort. This planning leads into a biennial rate setting cycle and offers a more accessible and flexible opportunity for dialog on broad issues than is possible under the strict administrative procedures of ratemaking. The self-financed character of BPA has made this public process a necessary and valuable one to assure that those who pay BPA's rates have a clear understanding and a strong voice in the plans for use of the resulting revenues. During 1989, the previous PIP engaged the region in discussion of major strategic, issues focussing on major areas. In 1990, BPA seeks discussion of the directions and plans specifically for fiscal years 1992 and 1993. The steps taken for those years will lay the foundation for the years beyond. Thus, we have subtitled this year's process, Staying fit for the long run.'' We have consulted extensively with customers and others in the region in developing these plans. In dozens of program--specific meetings, BPA staff have talked and listened to what others think our plans ought to be. PIP now gives us a chance to review their sum total, along with projections for revenues and our overall financial position. 8 tabs., 8 figs.

  6. BPA Statutes.

    SciTech Connect

    United States. Bonneville Power Administration.

    1995-01-01

    This publication includes the Bonneville Power Administration`s (BPA) authorities. It combines the two previous booklets of BPA authorities` and adds: sections of certain Appropriation Acts affecting BPA; a list of all other Appropriation Acts affecting BPA; a list of the acts authorizing Federal hydroelectric dams in the Columbia River Basin; portions of the Energy Policy Act of 1992 that specifically apply to BPA; portions of the Federal Power Act to provide context for the Energy Policy Act. The laws are in their United States Code format, rather than in the Public Law format as passed. Thus, the citation for Bonneville Project Act section 2(f) is shown as 16 USC {section}832a(f). Most people are familiar with the Public Law citations, so they have been retained and appear in italics at the end of each paragraph. In addition, later amendments to earlier laws are reflected in the United States Code language. For example, the Preference Act`s definition of ``Pacific Northwest`` (16 USC {section}837(b)) reflects the Northwest Power Act`s amendment of that term. The laws are presented in the numerical order they appear in the United States Code, rather than in the order in which they became law. Therefore, the Energy Policy Act of 1992 is presented first. This booklet is not, nor is it intended to be, an official reporter. All citations should be made to the United States Code or some other officially recognized reporter.

  7. Multifunctional data acquisition and analysis and optical sensors: a Bonneville Power Administration (BPA) update

    NASA Astrophysics Data System (ADS)

    Erickson, Dennis C.; Donnelly, Matt K.

    1995-04-01

    The authors present a design concept describing a multifunctional data acquisition and analysis architecture for advanced power system monitoring. The system is tailored to take advantage of the salient features of low energy sensors, particularly optical types. The discussion of the system concept and optical sensors is based on research at BPA and PNL and on progress made at existing BPA installations and other sites in the western power system.

  8. A Proposed Framework of Test Administration Methods

    ERIC Educational Resources Information Center

    Thompson, Nathan A.

    2008-01-01

    The widespread application of personal computers to educational and psychological testing has substantially increased the number of test administration methodologies available to testing programs. Many of these mediums are referred to by their acronyms, such as CAT, CBT, CCT, and LOFT. The similarities between the acronyms and the methods…

  9. Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

    SciTech Connect

    D.W. Nigg; William Bauer; Various Others

    2014-06-01

    Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70–85 ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.

  10. Final Study for Bonneville Power Administration's 1986 Variable Industrial Power Rate Proposal.

    SciTech Connect

    United States. Bonneville Power Administration.

    1986-06-01

    In this study, BPA is proposing a Variable Industrial Power (VI-86) rate option for its aluminum smelter loads. This rate would provide a predetermined contractual tie between the price of BPA's power and the US market price of aluminum. Establishing such a tie between input price (electricity) and output price (aluminum) will enhance the ability of aluminum producers to operate over the entire business cycle. This should reduce the cyclicality of smelter operations. Increasing the price of power when aluminum prices are high is intended to compensate BPA for any decrease in BPA's revenues when the lower rates occur. Various proposals for and discussions of a variable rate for BPA's direct service industrial (DSI) customers have occurred throughout the region over the past year. This study is the result of analyses conducted and evidence received from the rate hearings conducted on the Variable Rate (VI-86). This study describes the Variable rate proposed by BPA and the analyses conducted in support of the rate.

  11. Federal Aviation Administration retained savings program proposal

    SciTech Connect

    Hostick, D.J.; Larson, L.L.; Hostick, C.J.

    1998-03-01

    Federal legislation allows federal agencies to retain up to 50% of the savings associated with implementing energy efficiency and water conservation measures and practices. Given budget pressures to reduce expenditures, the use of retained savings to fund additional projects represents a source of funds outside of the traditional budget cycle. The Southwest Region Federal Aviation Administration (FAA) has tasked Pacific Northwest National Laboratory (PNNL) to develop a model retained savings program for Southwest Region FAA use and as a prototype for consideration by the FAA. PNNL recommends the following steps be taken in developing a Southwest Region FAA retained savings program: Establish a retained savings mechanism. Determine the level at which the retained savings should be consolidated into a fund. The preliminary recommendation is to establish a revolving efficiency loan fund at the regional level. Such a mechanism allows some consolidation of savings to fund larger projects, while maintaining a sense of facility ownership in that the funds will remain within the region.

  12. Grant Writing Skill Building: A Business Administration Curriculum Proposal

    ERIC Educational Resources Information Center

    Blankenship, Dianna; Jones, Irma; Lovett, Marvin

    2010-01-01

    This paper reviews the need for grant writing skills within various types of organizations and the resulting proposal for including grant writing within business administration curriculum at the undergraduate and/or graduate levels. An introduction precedes the results of a survey regarding current grant writing courses within AACSB schools of…

  13. 78 FR 42761 - Proposed Information Collection-2014 Election Administration and Voting Survey; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... COMMISSION Proposed Information Collection--2014 Election Administration and Voting Survey; Comment Request... this proposed information collection (2014 Election Administration and Voting Survey) to the Director of the Office of Management and Budget for approval. The 2014 Election Administration and...

  14. Science Receives Broad Support in Obama Administration's Proposed Budget

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2011-02-01

    With the U.S. federal deficit on target to hit $1.5 trillion this year, President Barack Obama's proposed federal budget of $3.73 trillion for fiscal year (FY) 2012, which begins on 1 October, has been greeted with mixed reviews since its release on 14 February. The proposal, which calls for a 5-year overall freeze on discretionary spending outside of security, generally is favorable for science and science agencies—particularly the National Science Foundation (NSF), the Department of Energy's (DOE) Office of Science, and the National Institute of Standards and Technology's (NIST) laboratories. However, some other agencies and bureaus, including the U.S. Geological Survey (USGS) and the Environmental Protection Agency (EPA), do not fare as well. A number of Republicans in Congress have panned the budget. Rep. Paul Ryan (R-Wis.), chair of the House of Representatives Committee on the Budget, said the president “has failed to tackle the urgent fiscal and economic threats before us.” Also, with the FY 2011 budget never having been enacted, House Committee on Appropriations chair Hal Rogers (R-Ky.) introduced a continuing resolution (H.R. 1) on 11 February that would fund the federal government for the remainder of the current fiscal year at a level $100 billion below the administration's request for this year.

  15. Landowner’s Guide for Compatible Use of BPA Rights-of-Way

    SciTech Connect

    2011-02-01

    Keeping transmission lines safe and reliable is a critical priority for the Bonneville Power Administration. The key element in achieving those objectives is BPA’s ability to construct, operate and maintain its transmission lines and rights-of-way — the area under and around the lines. You can help BPA keep these rights-of-way clear of trees, brush and structures that could affect the safety or reliability of the transmission system. Prior to planting, digging, or constructing within BPA’s rights-of-way, fill out BPA’s Land Use Application Form. The information you provide on the application helps BPA understand your proposed use and the potential impacts to public safety, and the safety of our crews. BPA also reviews the application to determine whether a proposed use of land is compatible with the construction, operation and maintenance of BPA transmission lines. Coordinating with BPA early in your planning process can keep you safe and avoid wasting time and money.

  16. 75 FR 64389 - Proposed Recommendation to the Social Security Administration for Occupational Information System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ... From the Federal Register Online via the Government Publishing Office ] SOCIAL SECURITY ADMINISTRATION Proposed Recommendation to the Social Security Administration for Occupational Information System (OIS) Development Planning; Request for Comment AGENCY: Social Security Administration. ACTION:...

  17. 76 FR 71342 - Proposed CERCLA Administrative Cost Recovery Settlement; River Forest Dry Cleaners Site, River...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; River Forest Dry Cleaners Site, River Forest, Cook County, IL AGENCY: Environmental Protection Agency (EPA). ACTION: Notice; request for public... proposed administrative settlement for recovery of past response costs concerning the River Forest...

  18. Power Subscription Strategy: Administrator`s Record of Decision.

    SciTech Connect

    United States. Bonneville Power Administration

    1998-12-01

    The Bonneville Power Administration (BPA) has decided to adopt a Power Subscription Strategy for entering into new power sales contracts with its Pacific Northwest customers. The Strategy equitably distributes the electric power generated by the Federal Columbia River Power System (FCRPS) within the framework of existing law. The Power Subscription Strategy addresses the availability of power; describes power products; lays out strategies for pricing, including risk management; and discusses contract elements. In proceeding with this Subscription Strategy, BPA is guided by and committed to the Fish and Wildlife funding Principles for the BPA announced by the Vice President of the US in September 1998. This Record of Decision (ROD) addresses the issues raised by commenters who responded to BPA`s Power Subscription Strategy Proposal during and after the comment period that began with the release of the Proposal on September 18, 1998. The ROD is organized in approximately the same way as the Proposal and the Power Subscription Strategy that BPA developed based on the comments received. Abbreviations of party names used in citations appear in the section just preceding this introduction; a list of all the commenters follows the text of the ROD.

  19. 40 CFR 77.4 - Administrator's action on proposed offset plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Administrator's action on proposed offset plans. 77.4 Section 77.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) EXCESS EMISSIONS § 77.4 Administrator's action on proposed offset plans....

  20. No Effect of Route of Exposure (Oral; Subcutaneous Injection) on Plasma Bisphenol A throughout 24 hr after Administration in Neonatal Female Mice

    PubMed Central

    Taylor, Julia A.; Welshons, Wade V.; vom Saal, Frederick S.

    2008-01-01

    Route of administration of chemicals in adults is an important factor in pharmacokinetics of chemicals such as bisphenol A (BPA), the monomer with estrogenic activity used to make polycarbonate plastic products and to line food and beverage cans. Based on findings in adults it has been proposed (CERHR, 2007) that non-oral routes of administration in newborn rodents would also lead to high exposure relative to oral administration. However, in fetuses and neonates, the enzyme that conjugates BPA (UDP-glucuronosyltransferase) is expressed at low levels, suggesting that there may be no differences in pharmacokinetics between oral and non-oral dosing. We thus conducted an analysis of plasma concentrations of unconjugated 3H-BPA after HPLC separation in postnatal day 3 female mice throughout the 24 hr after administering 3H-BPA orally or via subcutaneous injection at doses above and below the current EPA reference dose. We found no significant difference in plasma BPA based on route of administration in neonatal mice at either dose. However, compared to data from other studies conducted with adults, there was a markedly higher plasma BPA level after oral administration of BPA in newborn mice. This finding sets aside the belief that non-oral administration of BPA renders data as not suitable for consideration of the hazard posed by low-dose exposure to BPA during neonatal life. Therefore the large numbers of BPA studies that used non-oral administration at very low doses during the neonatal period should not be dismissed by scientists or the regulatory community based on route of administration. PMID:18295446

  1. No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female mice.

    PubMed

    Taylor, Julia A; Welshons, Wade V; Vom Saal, Frederick S

    2008-02-01

    Route of administration of chemicals in adults is an important factor in pharmacokinetics of chemicals such as bisphenol A (BPA), the monomer with estrogenic activity used to make polycarbonate plastic products and to line food and beverage cans. Based on findings in adults it has been proposed (CERHR, 2007) that non-oral routes of administration in newborn rodents would also lead to high exposure relative to oral administration. However, in fetuses and neonates, the enzyme that conjugates BPA (UDP-glucuronosyltransferase) is expressed at low levels, suggesting that there may be no differences in pharmacokinetics between oral and non-oral dosing. We thus conducted an analysis of plasma concentrations of unconjugated 3H-BPA after HPLC separation in postnatal day 3 female mice throughout the 24h after administering 3H-BPA orally or via subcutaneous injection at doses above and below the current EPA reference dose. We found no significant difference in plasma BPA based on route of administration in neonatal mice at either dose. However, compared to data from other studies conducted with adults, there was a markedly higher plasma BPA level after oral administration of BPA in newborn mice. This finding sets aside the belief that non-oral administration of BPA renders data as not suitable for consideration of the hazard posed by low-dose exposure to BPA during neonatal life. Therefore the large numbers of BPA studies that used non-oral administration at very low doses during the neonatal period should not be dismissed by scientists or the regulatory community based on route of administration. PMID:18295446

  2. Environmental Effects of BPA

    PubMed Central

    Canesi, Laura

    2015-01-01

    Research on bisphenol A (BPA) as an environmental contaminant has now major regulatory implications toward the ecosystem health, and hence it is incumbent on scientists to do their research to the highest standards possible, in order that the most appropriate decisions are made to mitigate the impacts to aquatic wildlife. However, the contribution given so far appears rather fragmented. The present overview aims to collect available information on the effects of BPA on aquatic vertebrates and invertebrates to provide a general scenario and to suggest future developments toward more comprehensive approaches useful for aquatic species protection. PMID:26674307

  3. 76 FR 26291 - Proposed CERCLA Administrative “Cost Recovery” Settlement; the Doe Run Resources Corporation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed CERCLA Administrative ``Cost Recovery'' Settlement; the Doe Run Resources Corporation.... Francois Mining Area, St. Francois County, Missouri with the following settling party: The Doe...

  4. 77 FR 44238 - Proposed Administrative Cost Recovery Settlement Under the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... amended (CERCLA), notice is hereby given of a proposed administrative settlement with The Doe Run... Mine Tailings Superfund Site in St. Francois County, Missouri. The settlement requires The Doe...

  5. 76 FR 14659 - Proposed CERCLA Administrative “Cost Recovery” Settlement; The Goldfield Corporation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed CERCLA Administrative ``Cost Recovery'' Settlement; The Goldfield Corporation AGENCY... of past and projected future response costs concerning the Newton County Mine Tailings Superfund...

  6. 77 FR 75677 - Proposed Submission of Information Collection for OMB Review; Comment Request; Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... From the Federal Register Online via the Government Publishing Office PENSION BENEFIT GUARANTY CORPORATION Proposed Submission of Information Collection for OMB Review; Comment Request; Administrative Appeals AGENCY: Pension Benefit Guaranty Corporation. ACTION: Notice of intent to request extension of...

  7. 76 FR 41248 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  8. 77 FR 38628 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  9. 77 FR 38629 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  10. 75 FR 55326 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  11. 77 FR 26549 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  12. 77 FR 13125 - Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  13. 77 FR 14784 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  14. 75 FR 57463 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency (EPA). ACTION: Notice; request...

  15. 77 FR 30282 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency. ACTION: Notice; request for...

  16. 76 FR 13615 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act AGENCY: Environmental Protection Agency (EPA). ACTION: Notice request...

  17. 77 FR 22785 - Proposed CERCLA Administrative Cost Recovery Settlement; Estate of Benjamin C. Schilberg...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Estate of Benjamin C. Schilberg, Cadlerock Properties Site, Ashford and Willington, CT AGENCY: Environmental Protection Agency....

  18. 76 FR 72921 - Proposed CERCLA Administrative Bona Fide Prospective Purchaser Settlement; The City of Dowagiac...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed CERCLA Administrative Bona Fide Prospective Purchaser Settlement; The City of Dowagiac Brownfield Redevelopment Authority AGENCY: Environmental Protection Agency. ACTION: Notice; request...

  19. 78 FR 21952 - Submission for OMB Review; Proposed Collection; Comment Request; General Services Administration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... continually improve service delivery. The customer-centric principle holds true whether our customers are... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Submission for OMB Review; Proposed Collection; Comment Request; General Services...

  20. 77 FR 21772 - Notice of Proposed Administrative Cashout Agreement Pursuant to the Comprehensive Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Notice of Proposed Administrative Cashout Agreement Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act; RE: Hassan Barrel Company AGENCY: U.S. Environmental...

  1. 76 FR 51029 - Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron... Mercury site in Iron Mountain, Dickenson County, Michigan with the following settling parties: The Salvation Army of Wauwatosa, Wisconsin, and the Trinity United Lutheran Church of Iron Mountain,...

  2. 78 FR 42944 - Proposed Administrative Cost Recovery Settlement Under the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ...: Environmental Protection Agency (EPA). ACTION: Notice; request for public comment. SUMMARY: In accordance with... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed Administrative Cost Recovery Settlement Under the Comprehensive Environmental...

  3. 75 FR 21292 - Proposed CERCLA Administrative Cost Recovery Settlement Agreement; AVX Corporation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement Agreement; AVX Corporation AGENCY... administrative settlement for recovery of projected future response oversight costs and performance of work... removal action, pre- payment of future response oversight costs, payment for long-term care of the...

  4. 77 FR 9652 - Proposed CERCLA Administrative Cost Recovery Settlement; Lake Linden Superfund Site in Lake...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Lake Linden Superfund Site in Lake Linden... administrative settlement for recovery of past response costs concerning the Lake Linden Superfund Site in Lake..., Chicago, Illinois, C-14J, 60604, (312) 886-6609. Comments should reference the Lake Linden Superfund...

  5. BPA Facts Pocket Edition

    SciTech Connect

    2014-04-01

    BPA will be an engine of the Northwest’s economic prosperity and environmental sustainability. BPA’s actions advance a Northwest power system that is a national leader in providing: • high reliability; • low rates consistent with sound business principles; • responsible environmental stewardship; and • accountability to the region. We deliver on these public responsibilities through a commercially successful business.

  6. 40 CFR 142.311 - What procedures allow the Administrator to object to a proposed small system variance or overturn...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administrator to object to a proposed small system variance or overturn a granted small system variance for a....311 What procedures allow the Administrator to object to a proposed small system variance or overturn... comments received prior to proposal. (b) The Administrator may review and object to any proposed...

  7. Administration's 1992 Budget Proposes a Healthy Boost for R&D.

    ERIC Educational Resources Information Center

    Hanson, David J.; And Others

    1991-01-01

    Discussed is the 1992 comprehensive federal budget proposed for the United States. The proposed budgets for the Defense Department, Health and Human Services, National Aeronautics and Space Administration, the National Science Foundation, Department of Agriculture, Environmental Protection Agency, and the National Institute of Standards and…

  8. 78 FR 57320 - Food and Drug Administration Food Safety Modernization Act: Proposed Rules on Foreign Supplier...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ...The Food and Drug Administration (FDA or we) is announcing two public meetings to discuss two proposed rules aimed at strengthening assurances that imported food meets the same safety standards as food produced domestically. The Foreign Supplier Verification Programs (FSVP) proposal establishes requirements for importers to verify that their foreign suppliers are implementing the modern,......

  9. 78 FR 40738 - Proposed CERCLA Administrative Cost Recovery Settlement; Double H Pesticide Burial Site

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Double H Pesticide Burial Site AGENCY... incurred for the Double H Pesticide Burial Site in Grandview, Yakima County, Washington. Under this proposed settlement, the settling parties are Double H, L.P.; James T. Hansen; Linda L. Hansen; George...

  10. Bonneville Power Administration 1998 Annual Report.

    SciTech Connect

    United States. Bonneville Power Administration.

    1998-01-01

    This is the 1998 annual report to the President by the Administrator and Chief Executive Officer of the Bonneville Power Administration. The topics of the report include financial highlights, letter to the President, review of 1998, financial data, management`s discussion and analysis, performance measures, financial statements, BPA executives, BPA offices, BPA profile.

  11. Sustainability at BPA 2013

    SciTech Connect

    2013-12-01

    THIS IS THE THIRD YEAR BPA has reported on sustainability program accomplishments. The report provides an opportunity to review progress made on sustainability initiatives, evaluate how far we have come and how much we can improve. The program has demonstrated maturation as the concepts of sustainability and resource conservation are communicated and understood. The sustainability program started as an employee-driven “grass roots” effort in 2010. Sustainability is becoming a consideration in how work is performed. The establishment of several policies supporting sustainability efforts proves the positive progress being made. In 2009, BPA became a founder and member of The Climate Registry, a nonprofit collaboration that sets standards to calculate, verify and report greenhouse gas emissions. This year, BPA completed and published our Greenhouse Gas inventory for the years of 2009, 2010 and 2011. The 2012 inventory is currently in the process of third-party verification and scheduled for public release in January 2014. These inventories provide a concrete measure of the progress we are making.

  12. Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model

    SciTech Connect

    Yang, Xiaoxia Doerge, Daniel R.; Fisher, Jeffrey W.

    2013-07-01

    Bisphenol A (BPA) has received considerable attention throughout the last decade due to its widespread use in consumer products. For the first time a physiologically based pharmacokinetic (PBPK) model was developed in neonatal and adult rats to quantitatively evaluate age-dependent pharmacokinetics of BPA and its phase II metabolites. The PBPK model was calibrated in adult rats using studies on BPA metabolism and excretion in the liver and gastrointestinal tract, and pharmacokinetic data with BPA in adult rats. For immature rats the hepatic and gastrointestinal metabolism of BPA was inferred from studies on the maturation of phase II enzymes coupled with serum time course data in pups. The calibrated model predicted the measured serum concentrations of BPA and BPA conjugates after administration of 100 μg/kg of d6-BPA in adult rats (oral gavage and intravenous administration) and postnatal days 3, 10, and 21 pups (oral gavage). The observed age-dependent BPA serum concentrations were partially attributed to the immature metabolic capacity of pups. A comparison of the dosimetry of BPA across immature rats and monkeys suggests that dose adjustments would be necessary to extrapolate toxicity studies from neonatal rats to infant humans. - Highlights: • A PBPK model predicts the kinetics of bisphenol A (BPA) in young and adult rats. • BPA metabolism within enterocytes is required for fitting of oral BPA kinetic data. • BPA dosimetry in young rats is different than adult rats and young monkeys.

  13. NASA RECON: Course development, administration, and evaluation. A research and development proposal

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Roquemore, Leroy

    1984-01-01

    This proposal addresses the development, administration, and evaluation of a set of transportable, college-level courses to educate science and engineering students in the effective use of automated scientific and technical information storage and retrieval systems, and, in particular, in the use of the NASA RECON system. Chapter 1 presents a brief introduction. Chapter 2 identifies general and specific objectives, i.e., needs analysis, course development, course administration, and course evaluation. Chapter 3 proposes the methodology to be used in successfully accomplishing these objectives. Chapter 4 highlights expected results and product deliverables, and Chapter 5 presents the project evaluation plan to be followed. Chapter 6 is a brief overview of the institutional resources available at the proposing institutions, i.e., at the University of Southwestern Louisiana and at Southern University to support the project. Chapter 7 proposes a budget, time schedule, and management plan. Chapter 8 is a summary of the foregoing.

  14. BPA/Puget Power Northwest Washington Transmission Project : Summary of the Supplemental Draft Environmental Statement.

    SciTech Connect

    United States. Bonneville Power Administration.

    1995-04-01

    BPA and Puget Sound Power and Light (Puget Power) are proposing to upgrade the existing electric transmission power system in the Whatcom and Skagit County area of northwest Washington to increase the capacity of the US-Canada Intertie transmission system. The project would satisfy the need to provide more ability to store and return energy with Canada, would provide additional capacity on the Intertie for anticipated increases in power transactions, and would increase flexibility in operation of the US and Canadian hydroelectric system. It would protect Puget Power`s local system against thermal overloads, and improve local reliability. In November 1993, Bonneville Power Administration (BPA), and Whatcom County (Washington) published a draft environmental impact statement (DEIS) for the proposed Northwest Washington Transmission Project. In order to present some shifts in need for the project and to permit additional review, BPA and Whatcom County have elected to issue a Supplemental Draft EIS. This Summary presents background material, explains project needs and purposes, and then focuses on alternatives and the possible effects.

  15. 78 FR 22542 - Proposed Administrative Settlement Agreement Under the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ...The United States Environmental Protection Agency (``EPA'') is proposing to enter into an administrative settlement agreement (``Settlement Agreement'') with L.E. Carpenter and Company (the ``Settling Party'') pursuant to Section 122 of the Comprehensive Environmental Response, Compensation, and Liability Act (``CERCLA''). The Settlement Agreement provides for Settling Parties' payment of......

  16. 78 FR 7428 - Notice of Proposed Administrative Cashout Agreement Pursuant to the Comprehensive Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ...Notice is hereby given of a proposed administrative settlement under CERCLA concerning the Miller Salvage Superfund Site (``Site'') in Latham, Pike County, Ohio. Subject to review and comment by the public pursuant to this Notice. The settlement resolves a United States Environmental Protection Agency claim under Sections 106, 107(a), and 122 of CERCLA, against one party who has executed......

  17. The Effect of Proposed Reagan Administration Cuts on University of Delaware Financial Aid Programs. Special Report.

    ERIC Educational Resources Information Center

    MacDonald, Douglas S.

    Proposed budget cuts by the Reagan Administration that will directly affect the financial aid programs at the University of Delaware are examined, along with the anticipated impacts of the cuts. The programs specifically slated for reduction in both funds and the number of students who will be eligible to participate in 1981-82 include the…

  18. 77 FR 64513 - Proposed Administrative Agreement for Collection of CERCLA Past Costs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... AGENCY Proposed Administrative Agreement for Collection of CERCLA Past Costs AGENCY: U.S Environmental... collection of a percentage of past response costs at the Ultimate Industries, Inc. Site. Respondent has agreed to pay $8,000 out of total past costs of approximately $83,776.10, in return for a covenant not...

  19. 77 FR 69620 - Casmalia Disposal Site; Notice of Proposed CERCLA Administrative De Minimis Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ...In accordance with section 122(i) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (CERCLA) and section 7003 of the Resource Conservation and Recovery Act (RCRA), EPA is hereby providing notice of a proposed administrative de minimis settlement concerning the Casmalia Disposal Site in Santa Barbara County, California (the Casmalia Disposal Site). Section......

  20. 75 FR 52745 - Proposed Administrative Settlement Agreement Under Section 122 of the Comprehensive Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ...The United States Environmental Protection Agency (``EPA'') is proposing to enter into an administrative settlement agreement (``Settlement Agreement'') with Georgia-Pacific Consumer Products, LP and International Paper Company (collectively ``Settling Parties'') pursuant to Section 122 of the Comprehensive Environmental Response, Compensation, and Liability Act (``CERCLA''), 42 U.S.C. 9622.......

  1. 78 FR 40140 - Proposed CERCLA Administrative Settlement Agreement and Order on Consent for the Mercury Refining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... AGENCY Proposed CERCLA Administrative Settlement Agreement and Order on Consent for the Mercury Refining... between EPA and Titan Wheel Corporation of Illinois (hereafter ``Titan'') pertaining to the Mercury.... Comments should be sent to the individual identified below and should reference the Mercury...

  2. 75 FR 44250 - Proposed Administrative Settlement Agreement Under Section 122 of the Comprehensive Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ...The United States Environmental Protection Agency (``EPA'') is proposing to enter into an administrative settlement agreement (``Settlement Agreement'') with the City of Jersey City, New Jersey (the ``Settling Party'') pursuant to Section 122 of the Comprehensive Environmental Response, Compensation, and Liability Act (``CERCLA''), 42 U.S.C. 9622. The Settlement Agreement provides for Settling......

  3. 75 FR 44251 - Proposed Administrative Settlement Agreement Under Section 122 of the Comprehensive Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ...The United States Environmental Protection Agency (``EPA'') is proposing to enter into an administrative settlement agreement (``Settlement Agreement'') with the Colgate-Palmolive Company (the ``Settling Party'') pursuant to Section 122 of the Comprehensive Environmental Response, Compensation, and Liability Act (``CERCLA''), 42 U.S.C. 9622. The Settlement Agreement provides for Settling Party......

  4. 76 FR 53898 - Proposed Administrative Settlement Agreement and Order on Consent; In Re: Ely Copper Mine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... AGENCY Proposed Administrative Settlement Agreement and Order on Consent; In Re: Ely Copper Mine... concerning the Ely Copper Mine Superfund Site in Vershire, Vermont with the following settling party: Ely... e-mail at gardner.ann@epa.gov . Additional information on the Ely Copper Mine Superfund Site can...

  5. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Findings of research misconduct and proposed administrative actions. 93.404 Section 93.404 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  6. 76 FR 77528 - Proposed CERCLA Administrative Cost Recovery Settlement; North Hollywood Operable Unit of the San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ...In accordance with Section 122(i) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (``CERCLA''), 42 U.S.C. 9622(i), notice is hereby given of a proposed administrative settlement for recovery of response costs concerning the North Hollywood Operable Unit of the San Fernando Valley Area 1 Superfund Site, located in the vicinity of Los Angeles, California,......

  7. 76 FR 79678 - Proposed CERCLA Administrative Cost Recovery Settlement; North Hollywood Operable Unit of the San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ...In accordance with Section 122(i) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (``CERCLA''), 42 U.S.C. 9622(i), notice is hereby given of a proposed administrative settlement for recovery of response costs concerning the North Hollywood Operable Unit of the San Fernando Valley Area 1 Superfund Site, located in the vicinity of Los Angeles, California,......

  8. 76 FR 81930 - Notice of Proposed Administrative Settlement Pursuant to the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... Abbott Mine/Turkey Run Mine Site located in Lake County, California (EPA Docket No. 2011-13). FOR FURTHER... administrative cost recovery settlement concerning the Abbott Mine/Turkey Run Mine Superfund Site (Site) in Lake County, California was executed by the Agency on November 14, 2011. The proposed settlement resolves...

  9. 78 FR 48434 - Proposed Administrative Cost Recovery Settlement Under Section 122(h) of the Comprehensive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Environmental Response Compensation and Liability Act, as Amended, 42 U.S.C. 9622(h), Carter Carburetor... a proposed administrative settlement with Carter Building, Inc., St. Louis, Missouri, for the compromise of past and projected future oversight costs concerning the Carter Carburetor Superfund Site in...

  10. 77 FR 29320 - Proposed Information Collection; Election Administration in Urban and Rural Areas; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ...; (c) ways to enhance the quality, utility, and clarity of the information to be collected; and (d... Response: 30 minutes. Estimated Total Annual Burden Hours: 1,500 hours. Frequency: One-time data collection... COMMISSION Proposed Information Collection; Election Administration in Urban and Rural Areas; Comment...

  11. 77 FR 28854 - Proposed Information Collection; Comment Request; Coastal Zone Management Program Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... Performance Management System, 27 hours. Estimated Total Annual Burden Hours: 12,104. Estimated Total Annual... information; (c) ways to enhance the quality, utility, and clarity of the information to be collected; and (d... National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request;...

  12. 77 FR 9905 - Proposed Information Collection; Election Administration in Urban and Rural Areas; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ...; (c) ways to enhance the quality, utility, and clarity of the information to be collected; and (d... Respondent: 1. Estimated Burden Per Response: 45 minutes. Estimated Total Annual Burden Hours: 2,250 hours... COMMISSION Proposed Information Collection; Election Administration in Urban and Rural Areas; Comment...

  13. 75 FR 57272 - Proposed CERCLA Administrative Cost Recovery Settlement; Gilberts/Kedzie Site, Village of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-20

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Gilberts/Kedzie Site, Village of Gilberts... settlement for recovery of past response costs concerning the Gilberts/Kedzie Site in the Village of Gilberts... whose telephone number is (312) 353- 3804. Comments should reference the Gilberts/Kedzie Site and...

  14. 76 FR 69733 - Proposed CERCLA Administrative Cost Recovery Settlement; Tracy Lead Battery Site, Tracy, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Tracy Lead Battery Site, Tracy, MN AGENCY... of past response costs concerning the Tracy Lead Battery Site in Tracy, Minnesota with the following.... Comments should reference the Tracy Lead Battery Site and EPA Docket No. CERCLA-05-2012-0001 and should...

  15. 78 FR 77673 - Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere, Boone... recovery of past response costs concerning the Cadie Auto Salvage Site in Belvidere, Boone County, Illinois..., Illinois 60604. Comments should reference the Cadie Auto Salvage Site, Belvidere, Boone County,...

  16. 78 FR 74128 - Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Cadie Auto Salvage Site, Belvidere, Boone... recovery of past response costs concerning the Cadie Auto Salvage Site in Belvidere, Boone County, Illinois..., Illinois 60604. Comments should reference the Cadie Auto Salvage Site, Belvidere, Boone County,...

  17. 77 FR 74006 - Proposed Administrative Cost Recovery Settlement Under the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ...In accordance with Section 122(i) of the Comprehensive Environmental Response Compensation and Liability Act, as amended (CERCLA), notice is hereby given of a proposed administrative settlement with Air Capitol Dial, Inc., for recovery of past response costs concerning the Radiation--Former Air Capitol Dial Superfund Site (the ``Site'') in Sedgwick County, Kansas. The settlement requires Air......

  18. 75 FR 4552 - Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment, and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... Violations Final Policy Statement (Audit Policy), 65 FR 19618 (Apr. 11, 2000). Hydro also provided... AGENCY Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment, and Opportunity... subsidiaries of Norsk Hydro Aluminum North America, Inc. (Hydro) to resolve violations of the Clean Water...

  19. 77 FR 58129 - Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment and Opportunity... resolve violations of the Clean Water Act (CWA), the Emergency Planning and Community Right-to-Know...

  20. 78 FR 5800 - Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ..., Correction and Prevention of Violations (Audit Policy), 65 FR 19,618 (April 11, 2000). EPA determined that... AGENCY Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment and Opportunity... resolve violations of the Clean Water Act (CWA) and the Emergency Planning and Community Right-to-Know...

  1. 76 FR 63904 - Proposed Information Collection; Comment Request; Coral Reef Conservation Program Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Coral..., extension 150, or Jenny.Waddell@noaagov. SUPPLEMENTARY INFORMATION: I. Abstract The Coral Reef Conservation Act of 2000 (Act) was enacted to provide a framework for conserving coral reefs. The Coral...

  2. Bonneville Power Administration Wildlife Mitigation Program : Draft Environmental Impact Statement.

    SciTech Connect

    United States. Bonneville Power Administration.

    1996-08-01

    Bonneville Power Administration (BPA) is responsible for mitigating the loss of wildlife habitat caused by the development of the Federal Columbia River Power System. BPA accomplishes this mitigation by funding projects consistent with those recommended by the Northwest Power Planning Council (Council). The projects are submitted to the Council from Indian Tribes, state agencies, property owners, private conservation groups, and other Federal agencies. Future wildlife mitigation actions with potential environmental impacts are expected to include land acquisition and management, water rights acquisition and management, habitat restoration and enhancement, installation of watering devices, riparian fencing, and similar wildlife conservation actions. BPA needs to ensure that individual wildlife mitigation projects are planned and managed with appropriate consistency across projects, jurisdictions, and ecosystems, as well as across time. BPA proposes to standardize the planning and implementation of individual wildlife mitigation projects funded by BPA. Alternative 1 is the No Action alternative. Five standardizing alternatives are identified to represent the range of possible strategies, goals, and procedural requirements reasonably applicable to BPA-funded projects under a standardized approach to project planning and implementation. All action alternatives are based on a single project planning process designed to resolve site-specific issues in an ecosystem context and to adapt to changing conditions and information.

  3. Charting a Course for the Future : BPA Programs in Perspectives, Technical Appendix.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-05-01

    Programs in Perspective is the Bonneville Power Administration`s public involvement process for engaging customers and other stakeholders in a regional dialog to set strategic direction and broad program plans for BPA. This process leads into a biennial rate setting cycle and offers a more accessible and flexible opportunity for dialog on broad issues than is possible under the strict administrative procedures of ratemaking. The self-financed character of BPA has made this public process a necessary and valuable one to assure that those who play BPA`s rates have a clear understanding and a strong voice in the plans for use of the resulting revenues.

  4. NOAA Would Receive an 11% Increase Under Obama Administration's Proposed Budget

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-05-01

    The White House's proposed fiscal year (FY) 2014 budget for the National Oceanic and Atmospheric Administration (NOAA) would provide the agency with 5.45 billion, 11% above the FY 2012 spend plan of 4.91 billion (see Table ). The proposal, which was sent to Congress on 10 April, would increase funding for operations, research, and facilities to 3.41 billion (up 7.97% over FY 2012) and for procurement, acquisition, and construction to 2.12 billion (up 17.51%). The budget proposal uses the FY 2012 spend plan as a comparison because Congress approved the FY 2013 appropriations only a few weeks before the FY 2014 proposal was released.

  5. 78 FR 78345 - Proposed Information Collection-2014 Election Administration and Voting Survey; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ...In compliance with Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, EAC announces an information collection and seeks public comment on the provisions thereof. The EAC, pursuant to 5 CFR 1320.5(a)(iii), intends to submit this proposed information collection (2014 Election Administration and Voting Survey) to the Director of the Office of Management and Budget for approval. The......

  6. 77 FR 53907 - Notice of Proposed Withdrawal Modification and Transfer of Administrative Jurisdiction; Montana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ...The Assistant Secretary of the Interior for Policy, Management and Budget proposes to modify Public Land Order (PLO) No. 1843, on behalf of the Bureau of Land Management (BLM), to transfer administrative jurisdiction of 5.16 acres of National Forest System (NFS) land from the U.S. Forest Service (USFS) to the BLM. The BLM would be the primary agency with responsibility and liability for the......

  7. Administration's Proposed NSF Budget Includes a 5.5% Increase for Geosciences

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-04-01

    The fiscal year (FY) 2014 proposed federal budget for the U.S. National Science Foundation (NSF) is $7.63 billion, 7.3% above the FY 2012 actual amount. NSF acting director Cora Marrett said the budget reflects the administration's recognition of NSF and the importance of funding basic research. "We are pleased about where we stand and hope that Congress will be just as pleased with the budget proposal and will help move things forward," she said during a meeting of the NSF Advisory Committee for Geosciences on 11 April. Budget comparisons are to FY 2012 because the 2013 appropriations were enacted at the end of March, less than 2 weeks before President Barack Obama sent the proposed budget to Congress.

  8. 9. Photocopy of Reinforced Concrete Details drawing (from the BPA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photocopy of Reinforced Concrete Details drawing (from the BPA Engineering Vault, Drawing C13-J2-342-D1, Sheet 6, 13 March 1939) - Bonneville Power Administration South Bank Substation, I-84, South of Bonneville Dam Powerhouse, Bonneville, Multnomah County, OR

  9. 7. Photocopy of Elevations drawing (from the BPA Engineering Vault, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photocopy of Elevations drawing (from the BPA Engineering Vault, Drawing C13-J2-342-D1, Sheet 3, 13 March 1939) - Bonneville Power Administration South Bank Substation, I-84, South of Bonneville Dam Powerhouse, Bonneville, Multnomah County, OR

  10. Mineralization of bisphenol A (BPA) by anodic oxidation with boron-doped diamond (BDD) electrode.

    PubMed

    Murugananthan, M; Yoshihara, S; Rakuma, T; Shirakashi, T

    2008-06-15

    Anodic oxidation of bisphenol A (BPA), a representative endocrine disrupting chemical, was carried out using boron-doped diamond (BDD) electrode at galvanostatic mode. The electro-oxidation behavior of BPA at BDD electrode was investigated by means of cyclic voltammetric technique. The extent of degradation and mineralization of BPA were monitored by HPLC and total organic carbon (TOC) value, respectively. The results obtained, indicate that the BPA removal at BDD depends on the applied current density (Iappl), initial concentration of BPA, pH of electrolyte and supporting medium. Galvanostatic electrolysis at BDD anode cause concomitant generation of hydroxyl radical that leads to the BPA destruction. The kinetics for the BPA degradation follows a pseudo-first order reaction with a higher rate constant 12.8x10(-5) s(-1) for higher Iappl value 35.7 mA cm(-2), indicating that the oxidation reaction is limited by Iappl control. Complete mineralization of BPA was achieved regardless of the variables and accordingly the mineralization current efficiency was calculated from the TOC removal measurements. Considering global oxidation process, the effect of supporting electrolytes has been discussed in terms of the electro generated inorganic oxidants. The better performance of BDD anode was proved on a comparative study with Pt and glassy carbon under similar experimental conditions. A possible reaction mechanism for BPA degradation involving three main aromatic intermediates, identified by GC-MS analysis, was proposed. PMID:18023975

  11. 78 FR 77171 - Proposed Disposal of George H.W. Bush and Clinton Administration Electronic Backup Tapes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... Federal Register on June 28, 2013 (78 FR 125, p. 39016), and contains a detailed description of this issue... Clinton Administration Electronic Backup Tapes'' on June 28, 2013, in the Federal Register (78 FR 125) for... RECORDS ADMINISTRATION Proposed Disposal of George H.W. Bush and Clinton Administration Electronic...

  12. BPA's Eighth Annual Energy Conservation Management Conference : Proceedings.

    SciTech Connect

    Energy Conservation Management Conference; United States. Bonneville Power Administration.

    1981-01-01

    The five-year energy conservation program at Bonneville Power Administration (BPA) is described at the conference. An overview of the program is presented. Topics covered in panel discussions include: how utilities can work effectively with weatherization contractors, homebuilders, energy auditors, and weatherization material suppliers; mechanisms for implementing conservation programs in the commercial sector; experiences gained in existing residential weatherization programs; and streamlining relationships between consumers, utilities, and BPA in providing services and getting feedback. The planning, programming, technical assistance, and engineering thrusts of BPA's conservation programs are discussed. Indoor air quality, renewable energy, and the regulator's role in relationships to energy conservation are discussed. Passive solar programs, DOE initiatives in solar and conservation for buildings, conservation potential in the commercial and industrial sectors, and current conservation research and development are also discussed. (MCW)

  13. Influenza viral load and peramivir kinetics after single administration and proposal of regimens for peramivir administration against resistant variants.

    PubMed

    Sato, Masatoki; Ito, Masaki; Suzuki, Shigeo; Sakuma, Hiroko; Takeyama, Aya; Oda, Shinichi; Watanabe, Masahiro; Hashimoto, Koichi; Miyazaki, Kyohei; Kawasaki, Yukihiko; Hosoya, Mitsuaki

    2015-03-01

    We estimated the efficacy of the current single administration of peramivir on the basis of peramivir pharmacokinetics in the upper respiratory tract (URT) and determined the predictive peramivir concentration-time curve to assess its efficacy against viruses with decreased susceptibility to neuraminidase inhibitors. Serum, nasal swab, or aspiration samples were collected from 28 patients treated with 10 mg/kg body weight peramivir. The sequential influenza viral RNA load and susceptibility after peramivir administration were measured using a quantitative real-time reverse transcription-PCR and neuraminidase inhibition assay. The peramivir concentrations in the serum and URT after a single administration at 10 mg/kg were measured, and the predictive blood and URT peramivir concentration-time curves were determined to assess various administration regimens against resistant variants. The peramivir concentration decreased to <0.1% of the maximum concentration of drug in serum (Cmax) at 24 h after administration. Rapid elimination of peramivir from the URT by 48 h after administration may contribute to an increase in the influenza A viral load after day 3 but not to a decrease in the influenza B viral load, despite the absence of a decrease in the susceptibility to peramivir. A longer maintenance of a high level of peramivir in the URT is expected by divided administration rather than once-daily administration. When no clinical improvement is observed in patients with normal susceptibility influenza A and B, peramivir readministration should be considered. In severe cases caused by resistant variants, better inhibitory effectiveness and less frequent adverse events are expected by divided administration rather than once-daily administration with an increased dosage. PMID:25547357

  14. Influenza Viral Load and Peramivir Kinetics after Single Administration and Proposal of Regimens for Peramivir Administration against Resistant Variants

    PubMed Central

    Ito, Masaki; Suzuki, Shigeo; Sakuma, Hiroko; Takeyama, Aya; Oda, Shinichi; Watanabe, Masahiro; Hashimoto, Koichi; Miyazaki, Kyohei; Kawasaki, Yukihiko; Hosoya, Mitsuaki

    2014-01-01

    We estimated the efficacy of the current single administration of peramivir on the basis of peramivir pharmacokinetics in the upper respiratory tract (URT) and determined the predictive peramivir concentration-time curve to assess its efficacy against viruses with decreased susceptibility to neuraminidase inhibitors. Serum, nasal swab, or aspiration samples were collected from 28 patients treated with 10 mg/kg body weight peramivir. The sequential influenza viral RNA load and susceptibility after peramivir administration were measured using a quantitative real-time reverse transcription-PCR and neuraminidase inhibition assay. The peramivir concentrations in the serum and URT after a single administration at 10 mg/kg were measured, and the predictive blood and URT peramivir concentration-time curves were determined to assess various administration regimens against resistant variants. The peramivir concentration decreased to <0.1% of the maximum concentration of drug in serum (Cmax) at 24 h after administration. Rapid elimination of peramivir from the URT by 48 h after administration may contribute to an increase in the influenza A viral load after day 3 but not to a decrease in the influenza B viral load, despite the absence of a decrease in the susceptibility to peramivir. A longer maintenance of a high level of peramivir in the URT is expected by divided administration rather than once-daily administration. When no clinical improvement is observed in patients with normal susceptibility influenza A and B, peramivir readministration should be considered. In severe cases caused by resistant variants, better inhibitory effectiveness and less frequent adverse events are expected by divided administration rather than once-daily administration with an increased dosage. PMID:25547357

  15. NASA Engineering and Technology Advancement Office: A proposal to the administrator

    NASA Technical Reports Server (NTRS)

    Schulze, Norman R.

    1993-01-01

    NASA has continually had problems with cost, schedule, performance, reliability, quality, and safety aspects in programs. Past solutions have not provided the answers needed, and a major change is needed in the way of doing business. A new approach is presented for consideration. These problems are all engineering matters, and therefore, require engineering solutions. Proper engineering tools are needed to fix engineering problems. Headquarters is responsible for providing the management structure to support programs with appropriate engineering tools. A guide to define those tools and an approach for putting them into place is provided. Recommendations include establishing a new Engineering and Technology Advancement Office, requesting a review of this proposal by the Administrator since this subject requires a top level decision. There has been a wide peer review conducted by technical staff at Headquarters, the Field Installations, and others in industry as discussed.

  16. 75 FR 3925 - Proposed Information Collection Request for Administrative Procedures-20 CFR 601 Including Form...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ...--20 CFR 601 Including Form MA 8-7; Comment Request on Extension Without Change AGENCY: Employment and..., Employment and Training Administration regulations, 20 CFR 601, Administrative Procedures,...

  17. Review of BPA Funded Sturgeon, Resident Fish and Wildlife Projects for 1990/1991.

    SciTech Connect

    United States. Bonneville Power Administration.

    1990-12-01

    The Bonneville Power Administration (BPA) held a public meeting on November 19--21, 1991, for the purpose of review, coordination, and consultation of the BPA-funded projects for sturgeon, resident fish, and wildlife in the Columbia River Basin (Basin). The comments received after the meeting were favorable and the participants agreed that the meeting was stimulating and productive. The information exchanged should lead to better coordination with other projects throughout the Basin. This document list the projects by title, the project leaders and BPA's project officers, and an abstract of each leader's presentation.

  18. 25 CFR 900.24 - Can a contract proposal for an Indian tribe or tribal organization's share of administrative...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... organization's share of administrative programs, functions, services, and activities be declined for any reason... Can a contract proposal for an Indian tribe or tribal organization's share of administrative programs... listed above. If a contract affects the preexisting level of services to any other tribe, the...

  19. 25 CFR 900.24 - Can a contract proposal for an Indian tribe or tribal organization's share of administrative...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... organization's share of administrative programs, functions, services, and activities be declined for any reason... Can a contract proposal for an Indian tribe or tribal organization's share of administrative programs... listed above. If a contract affects the preexisting level of services to any other tribe, the...

  20. 25 CFR 900.24 - Can a contract proposal for an Indian tribe or tribal organization's share of administrative...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... organization's share of administrative programs, functions, services, and activities be declined for any reason... Can a contract proposal for an Indian tribe or tribal organization's share of administrative programs... listed above. If a contract affects the preexisting level of services to any other tribe, the...

  1. 25 CFR 900.24 - Can a contract proposal for an Indian tribe or tribal organization's share of administrative...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... organization's share of administrative programs, functions, services, and activities be declined for any reason... Can a contract proposal for an Indian tribe or tribal organization's share of administrative programs... listed above. If a contract affects the preexisting level of services to any other tribe, the...

  2. Assessment of the Geothermal Potential Within the BPA Marketing Area.

    SciTech Connect

    Lund, John W.; Allen, Eliot D.

    1980-07-01

    The potential of geothermal energy is estimated that can be used for direct heat applications and electrical power generation within the Bonneville Power Administration (BPA) marketing area. The BPA marketing area includes three principal states of Oregon, Washington, and Idaho and portions of California, Montana, Wyoming, Nevada, and Utah bordering on these three states. This area covers approximately 384,000 square miles and has an estimated population of 6,760,000. The total electrical geothermal potential within this marketing area is 4077 MW/sub e/ from hydrothermal resources and 16,000 MW/sub e/ from igneous systems, whereas the total thermal (wellhead) potential is 16.15 x 10/sup 15/ Btu/y. Approximately 200 geothermal resource sites were initially identified within the BPA marketing area. This number was then reduced to about 100 sites thought to be the most promising for development by the year 2000. These 100 sites, due to load area overlap, were grouped into 53 composite sites; 21-3/4 within BPA preference customer areas and 31-1/4 within nonpreference customer areas. The geothermal resource potential was then estimated for high-temperature (> 302/sup 0/F = 150/sup 0/C), intermediate-temperature (194 to 302/sup 0/F = 90 to 150/sup 0/C), and low-temperature (< 194/sup 0/F = 90/sup 0/C) resources.

  3. 77 FR 52708 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... (75 FR 80542). Below we provide the BPA projected average estimates for the next three years: \\1\\ \\1...: Bonneville Power Administration (BPA), DOE. ACTION: 30-Day notice of submission of information...

  4. 75 FR 23781 - Agency Information Collection Activities; Proposed Collection; Comment Request; Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... Collection; Comment Request; Administrative Procedures for the Clinical Laboratory Improvement Amendments of... procedures for the Clinical Laboratory Improvement Amendments of 1988 (CLIA) categorization. DATES:...

  5. Faculty-Administration Conflict in California Public Junior Colleges: An Analysis and a Proposal for Resolution.

    ERIC Educational Resources Information Center

    Niland, William Patrick

    This study identifies areas of administration-faculty conflict and offers a strategy for resolution. Information was collected by mail and interview. From the findings, inferences were drawn relating to the causes of conflict, as shown by the differences in perception of the administrator and teacher, in attitudes to the open-door policy, and in…

  6. 77 FR 21564 - Agency Information Collection Activities; Proposed Collection; Comment Request; Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... Collection; Comment Request; Administrative Detention and Banned Medical Devices AGENCY: Food and Drug... appropriate, and other forms of information technology. Administrative Detention and Banned Medical Devices... devices. DATES: Submit either electronic or written comments on the collection of information by June...

  7. Proposal for a European Public Health Research Infrastructure for Sharing of health and Medical administrative data (PHRIMA).

    PubMed

    Burgun, Anita; Oksen, Dina V; Kuchinke, Wolfgang; Prokosch, Hans-Ulrich; Ganslandt, Thomas; Buchan, Iain; van Staa, Tjeerd; Cunningham, James; Gjerstorff, Marianne L; Dufour, Jean-Charles; Gibrat, Jean-Francois; Nikolski, Macha; Verger, Pierre; Cambon-Thomsen, Anne; Masella, Cristina; Lettieri, Emanuele; Bertele, Paolo; Salokannel, Marjut; Thiebaut, Rodolphe; Persoz, Charles; Chêne, Geneviève; Ohmann, Christian

    2015-01-01

    In Europe, health and medical administrative data is increasingly accumulating on a national level. Looking further than re-use of this data on a national level, sharing health and medical administrative data would enable large-scale analyses and European-level public health projects. There is currently no research infrastructure for this type of sharing. The PHRIMA consortium proposes to realise the Public Health Research Infrastructure for Sharing of health and Medical Administrative data (PHRIMA) which will enable and facilitate the efficient and secure sharing of healthcare data. PMID:26262306

  8. Molecular Mechanisms of Action of BPA

    PubMed Central

    Acconcia, Filippo; Pallottini, Valentina

    2015-01-01

    Bisphenol A (BPA) exposure has been associated with serious endocrine-disrupting effects in humans and wildlife. Toxicological and epidemiological studies evidenced that BPA increases body mass index and disrupts normal cardiovascular physiology by interfering with endogenous hormones in rodents, nonhuman primates, and cell culture test systems. The BPA concentration derived from these experiments were used by government regulatory agencies to determine the safe exposure levels of BPA in humans. However, accumulating literature in vivo and in vitro indicate that at concentrations lower than that reported in toxicological studies, BPA could elicit a different endocrine-disrupting capacity. To further complicate this picture, BPA effects rely on several and diverse mechanisms that converge upon endocrine and reproductive systems. If all or just few of these mechanisms concur to the endocrine-disrupting potential of low doses of BPA is at present still unclear. Thus, taking into account that the incidence and/or prevalence of health problems associated with endocrine disruption have increased worldwide, the goal of the present review is to give an overview of the many mechanisms of BPA action in order to decipher whether different mechanisms are at the root of the effect of low dose of BPA on endocrine system. PMID:26740804

  9. 76 FR 77997 - Proposed CERCLA Administrative Cashout Settlement; The Atlantic Richfield Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    .... Gaydosh, Assistant Regional Administrator, Office of Enforcement and Compliance and Environmental Justice... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION...: Environmental Protection Agency. ACTION: Notice; request for public comment. SUMMARY: In accordance with...

  10. 78 FR 303 - General Services Administration Acquisition Regulation; Information Collection; Proposal To Lease...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-03

    ...) has various mission responsibilities related to the acquisition and provision of real property management, and disposal of real and personal property. These mission responsibilities generate requirements... Paperwork Reduction Act, the General Services Administration will be submitting to the Office of...

  11. 40 CFR 142.311 - What procedures allow the Administrator to object to a proposed small system variance or overturn...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false What procedures allow the Administrator to object to a proposed small system variance or overturn a granted small system variance for a public water system serving 3,300 or fewer persons? 142.311 Section 142.311 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)...

  12. 40 CFR 78.20 - Appeal of decision of Administrator or proposed decision to the Environmental Appeals Board.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Appeal of decision of Administrator or proposed decision to the Environmental Appeals Board. 78.20 Section 78.20 Protection of Environment... Presiding Officer, the Environmental Appeals Board may issue sua sponte in its discretion a notice of...

  13. 77 FR 31611 - Proposed CERCLA Section 122(g)(4) Administrative Agreement and Order on Consent for the Mercury...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... AGENCY Proposed CERCLA Section 122(g)(4) Administrative Agreement and Order on Consent for the Mercury... the Mercury Refining Superfund Site (``Site'') located in the Towns of Guilderland and Colonie, Albany... Hazardous Substance Superfund Mercury Refining Superfund Site Special Account, which combined total...

  14. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false How does the Administrator provide States an opportunity to comment on proposed Federal financial assistance and direct Federal development? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION...

  15. 44 CFR 4.8 - How does the Administrator provide an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false How does the Administrator provide an opportunity to comment on proposed Federal financial assistance and direct Federal development? 4.8 Section 4.8 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY...

  16. 43 CFR 404.51 - Are proposed projects under the Rural Water Supply Program reviewed by the Administration?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Are proposed projects under the Rural Water Supply Program reviewed by the Administration? 404.51 Section 404.51 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Feasibility Studies §...

  17. 75 FR 53301 - Proposed Cercla Administrative Order on Consent for the Standard Mine Site, Gunnison County, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... Administrative Order on Consent (``AOC'') under sections 104, 106, 107, and 122 of CERCLA, 42 U.S.C. 9604, 9606... County, Colorado. The proposed AOC is for recovery of past and projected future response costs concerning... notice, the Agency will consider all comments received on the AOC and may modify or withdraw its...

  18. 75 FR 51267 - Proposed Cercla Administrative Order On Consent for the Kerber Creek Site, Saguache County, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... Administrative Order on Consent (``AOC'') under sections 104, 106, 107, and 122 of CERCLA, 42 U.S.C. 9604, 9606... the subject of this proposed AOC is all areas to which hazardous substances and/or pollutants or... Bonanza town site, below the Forest Service boundary, and extending to the town of Villa Grove. This...

  19. 43 CFR 404.51 - Are proposed projects under the Rural Water Supply Program reviewed by the Administration?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Water Supply Program reviewed by the Administration? 404.51 Section 404.51 Public Lands: Interior... SUPPLY PROGRAM Feasibility Studies § 404.51 Are proposed projects under the Rural Water Supply Program... the Reclamation's Rural Water Supply Program. This includes review under Executive Order 12322...

  20. 76 FR 81929 - San Fernando Valley Area 2; Notice of Proposed Administrative Order on Consent Re: 4057 and 4059...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY San Fernando Valley Area 2; Notice of Proposed Administrative Order on Consent Re: 4057 and 4059 Goodwin Avenue, Los Angeles, CA AGENCY: Environmental Protection Agency (EPA). ACTION: Notice; request...

  1. 76 FR 3886 - Proposed Administrative Settlement Agreement Under Section 122(h) of the Comprehensive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... Hamilton Township, Atlantic County, NJ AGENCY: Environmental Protection Agency. ACTION: Notice of proposed...'Imperio Property Superfund Site, located in Hamilton Township, Atlantic County, New Jersey (``Site'')....

  2. BPA/Puget Power Northwest Washington Transmission Project Final Environmental Impact Statement.

    SciTech Connect

    United States. Bonneville Power Administration.

    1995-08-01

    Bonneville Power Administration (BPA) and Puget Sound Power & Light Company (Puget Power) propose to upgrade the existing high-voltage transmission system in the Whatcom and Skagit counties area between the towns of Custer and Sedro Woolley, including some areas within the City of Bellingham, starting in 1995. A Draft Environmental Impact Statement (DEIS) for the project was issued in November 1993, followed by a 45-day public comment period. Public response to the DEIS included the identification of several new transmission route alternatives in the Lake Whatcom area. BPA issued a Supplemental DEIS in April 1995 to provide a second public review-and-comment period. Rebuilding an existing 230-kV line to a double-circuit 230-kV transmission line was identified in the Supplemental DEIS as the Proposed Action. The Supplemental DEIS also examined in detail a North Shore Road alternative which was proposed by some members of the public. Public comments on the EIS were listed and responded to in the Supplemental DEIS. In May 1995, a second set of open houses and public meetings was held to review the Supplemental DEIS. Electromagnetic field (EMF) effects raised as an issue in the DEIS continued to be an issue of public concern in the meetings. The EIS has identified impacts that would generally be classified as low to moderate and localized. Effects on soils and water resources in sensitive areas (e.g., near Lake Whatcom) would be low to moderate; there would be little change in magnetic fields; noise levels would remain at existing levels; and land use and property value impacts would be minimal. Threatened and endangered species would not be adversely affected, and all proposed actions in wetlands would be covered by a Corps of Engineers Nationwide Permit. Visual and socioeconomic would be low to moderate. There would be no effect on cultural resources.

  3. 75 FR 36388 - Proposed Administrative Cost Recovery Settlement Under Section 122(h) of the Comprehensive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... Environmental Response Compensation and Liability Act, as Amended, 42 U.S.C. 9622(h), Doe Run Resources... administrative settlement with Doe Run Resources Corporation (Doe Run), for recovery of past response costs concerning the response actions taken by Doe Run to address lead contamination associated with a...

  4. 76 FR 18549 - Casmalia Disposal Site; Notice of Proposed CERCLA Administrative De Minimis Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... Wildlife Service (USFWS) and the National Oceanic and Atmospheric Administration (NOAA). These 49 parties... Information and Electronic Systems Integration Inc.; Cenveo; ConAgra Foods, Inc.; Continental Chemical Co...; General Tire Service; Hercules, Incorporated for itself, Mica Corporation and US Filter; Hobie Cat...

  5. 77 FR 52021 - Proposed CERCLA Administrative Settlement Agreement and Order on Consent for the Mercury Refining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended (``CERCLA''), notice... minimis administrative settlement agreement and order on consent pursuant to Section 122(g)(4) of CERCLA... Group, Inc., Genesys Regional Medical Center, Ingot Metal Company, Ltd., Purina Mills, LLC, Shred-A-...

  6. 76 FR 56452 - Proposed Administrative Settlement Agreement and Order on Consent for Removal Action for 6472...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... Agreement and Order on Consent for Removal Action (``AOC'') for a removal action at the 6472 Selkirk Avenue... approval of EPA and the U.S. Department of Justice. The proposed AOC relates to the removal action at the.... 9604(a)(1). EPA is negotiating the proposed AOC pursuant to its authority under Section 122 of...

  7. 75 FR 34448 - Proposed CERCLA Administrative Cost Recovery Settlement; Great Lakes Container Corporation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... costs (Section XV of the proposed settlement). The Agency will consider all comments received and may..., Environmental Protection Agency--Region I, 5 Post Office Square--Suite 100 (ORA18-1), Boston, MA 02109-3912....

  8. 77 FR 26275 - Bonneville Power Administration; Montana-to-Washington Transmission System Upgrade Project EIS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ...: Bonneville Power Administration (BPA), Department of Energy (DOE). ACTION: Notice of intent to prepare an Environmental Impact Statement (EIS) and notice of floodplain and wetlands involvement. SUMMARY: BPA intends to... reinforcements of five existing BPA substations, placement of new conductor on sections of an existing...

  9. Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

    SciTech Connect

    D.W. Nigg; Various Others

    2014-06-01

    BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76 ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.

  10. Design of Studies for Development of BPA Fish and Wildlife Mitigation Accounting Policy Phase II, Volume II, 1985-1988 Technical Report.

    SciTech Connect

    Kneese, Allen V.

    1988-08-01

    The incremental costs of corrective measures to lessen the environmental impacts of the hydroelectric system are expected to increase and difficult questions to arise about the costs, effectiveness, and justification of alternative measures and their systemwide implications. The BPA anticipate this situation by launching a forward-looking research program aimed at providing methodological tools and data suitable for estimating the productivity and cost implications of mitigation alternatives in a timely manner with state-of-the-art accuracy. Resources for the Future (RFF) agreed at the request of the BPA to develop a research program which would provide an analytical system designed to assist the BPA Administrator and other interested and responsible parties in evaluating the ecological and economic aspects of alternative protection, enhancement, and mitigation measures. While this progression from an ecological understanding to cost-effectiveness analyses is straightforward in concept, the complexities of the Columbia River system make the development of analytical methods far from simple in practice. The Phase 2 final report outlines the technical issues involved in developing an analytical system and proposes a program of research to address these issues. The report is presented in the Summary Report (Volume 1), and the present volume which consists of three technical reports: Part I, Modeling the Salmon and Steelhead Fisheries of the Columbia River Basin; Part II, Models for Cost-Effectiveness Analysis; and Part III, Ocean Fisheries Harvest Management.

  11. 25 CFR 900.24 - Can a contract proposal for an Indian tribe or tribal organization's share of administrative...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Can a contract proposal for an Indian tribe or tribal organization's share of administrative programs, functions, services, and activities be declined for any reason other than the five reasons specified in § 900.22? 900.24 Section 900.24 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR,...

  12. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  13. 76 FR 39401 - Proposed CERCLA Administrative Cost Recovery Settlement Agreement; Textron Inc., Whittaker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... costs (Section XV of the proposed settlement). The Agency will consider all comments received and may... Library, 129 Main St., Concord, MA 01742 and at U.S. EPA Region 1, 5 Post Office Square, Suite 100, Boston... settlement is available for public inspection at U.S. EPA Region 1, OSRR Records and Information Center,...

  14. 78 FR 13056 - Proposed CERCLA Administrative Cost Recovery Settlement; in re: Factory H Superfund Site, Meriden...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... to Hugh W. Martinez, Senior Enforcement Counsel, U.S. Environmental Protection Agency, Region 1, 5... CONTACT: A copy of the proposed settlement may be obtained from Hugh W. Martinez, Senior Enforcement...), Boston, MA 02109-3912 (telephone no. (617) 918-1867; email Martinez.hugh@epa.gov ). Dated: December...

  15. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  16. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  17. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Findings of research misconduct and proposed... PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.404 Findings of research misconduct and...

  18. 78 FR 10107 - Food and Drug Administration Food Safety Modernization Act: Proposed Rules To Establish Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... Good Manufacturing Practice and Hazard Analysis and Risk-Based Preventive Controls for Human Food... human consumption (the produce safety proposed rule) and for current good manufacturing practice and... 1960s, FDA established HACCP-based regulations for seafood (21 CFR part 123) in 1995 (60 FR...

  19. 78 FR 6762 - Food and Drug Administration Food Safety Modernization Act: Proposed Rules To Establish Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... Good Manufacturing Practice and Hazard Analysis and Risk-Based Preventive Controls for Human Food... produce safety proposed rule) and for current good manufacturing practice and hazard analysis and risk... (60 FR 65096, December 18, 1995) and for juice (21 CFR part 120) in 2001 (66 FR 6138, January 19,...

  20. 77 FR 37523 - Proposed Revisions to the Export Administration Regulations: Implementation of Export Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ..., 2011 (76 FR 47527). On January 18, 2011, President Barack Obama issued Executive Order 13563, affirming... protect and enhance U.S. national security interests. On July 15, 2011 (76 FR 41958), BIS published a... regulatory framework, subsequent rules, including the November 7, 2011 (76 FR 68675) proposed rule,...

  1. 77 FR 38802 - Proposed CERCLA Administrative Cost Recovery Settlement; Standex International Corporation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ...: Environmental Protection Agency. ACTION: Notice; request for public comment. SUMMARY: Notice is hereby given of... proposed settlement is available for public inspection at the U.S. Environmental Protection Agency, Region... from Catherine Garypie, U.S. Environmental Protection Agency, 77 W. Jackson Boulevard (C-14J),...

  2. 78 FR 36547 - Proposed Administrative Settlement Agreement Under the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ..., Atlantic County, New Jersey AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Proposed... the U.S. Environmental Protection Agency, Region 2, Office of Regional Counsel, New Jersey Superfund... Regional Counsel, U.S. Environmental Protection Agency, Region 2, 17th Floor, 290 Broadway, New York,...

  3. Bisphenol A (BPA) in food contact materials - new scientific opinion from EFSA regarding public health risk.

    PubMed

    Ćwiek-Ludwicka, Kazimiera

    2015-01-01

    The wide use of bisphenol A (BPA) as a monomer in plastics manufacture or epoxy resins intended for food contact materials (FCM) has triggered numerous concerns due to toxicological findings indicating possible endocrine disrupting properties. This article traces the evolution of the scientific opinions since 1986 when the Tolerable Daily Intake (TDI) for BPA and its specific migration limit (SML) from plastic FCM into food were proposed for the first time by the Scientific Committee for Food (SCF). Resent extensive scientific studies concerning refined data on toxicity and exposure to BPA from food and non-food sources (eg. dust, cosmetics, thermal paper), including the most vulnerable groups of population, allowed the European Food Safety Authority (EFSA) to reduce the TDI of BPA from previously 50 µg/kg bw/day to now 4 µg/kg bw/day. EFSA's latest scientific opinion published in 2015 concludes that basing on the current estimations of total exposure to BPA from dietary and non-dietary sources for infants, children and adolescents is below the temporary TDI of 4 μg/kg bw/day. EFSA has also underlined that BPA poses no health risk at the estimated exposure levels of any population age group, including unborn children and the elderly. However, EFSA has indicated that some data on exposure and toxicological effects still require clarifications. PMID:26656411

  4. Proposed framework for the Western Area Power Administration Environmental Risk Management Program

    SciTech Connect

    Glantz, C.S.; DiMassa, F.V.; Pelto, P.J.; Brothers, A.J.; Roybal, A.L.

    1994-12-01

    The Western Area Power Administration (Western) views environmental protection and compliance as a top priority as it manages the construction, operation, and maintenance of its vast network of transmission lines, substations, and other facilities. A recent Department of Energy audit of Western`s environmental management activities recommends that Western adopt a formal environmental risk program. To accomplish this goal, Western, in conjunction with Pacific Northwest Laboratory, is in the process of developing a centrally coordinated environmental risk program. This report presents the results of this design effort, and indicates the direction in which Western`s environmental risk program is heading. Western`s environmental risk program will consist of three main components: risk communication, risk assessment, and risk management/decision making. Risk communication is defined as an exchange of information on the potential for threats to human health, public safety, or the environment. This information exchange provides a mechanism for public involvement, and also for the participation in the risk assessment and management process by diverse groups or offices within Western. The objective of risk assessment is to evaluate and rank the relative magnitude of risks associated with specific environmental issues that are facing Western. The evaluation and ranking is based on the best available scientific information and judgment and serves as input to the risk management process. Risk management takes risk information and combines it with relevant non-risk factors (e.g., legal mandates, public opinion, costs) to generate risk management options. A risk management tool, such as decision analysis, can be used to help make risk management choices.

  5. Liberal or restricted fluid administration: are we ready for a proposal of a restricted intraoperative approach?

    PubMed Central

    2014-01-01

    Background Fluid management in the perioperative period has been extensively studied but, despite that, “the right amount” still remains uncertain. The purpose of this paper is to summarize the state of the art of intraoperative fluid approach today. Discussion In the current medical literature there are only heterogeneous viewpoints that gives the idea of how confusing the situation is. The approach to the intraoperative fluid management is complex and it should be based on human physiology and the current evidence. Summary An intraoperative restrictive fluid approach in major surgery may be beneficial while Goal-directed Therapy should be superior to the liberal fluid strategy. Finally, we propose a rational approach currently used at our institution. PMID:25104915

  6. Review of BPA Funded Sturgeon, Resident Fish and Wildlife Projects, 1989/1990.

    SciTech Connect

    United States. Bonneville Power Administration.

    1990-12-01

    The Bonneville Power Administration (BPA) held a public meeting on November 6-7, 1990, for the purpose of review, coordination, and consultation of the BPA-funded projects for sturgeon, resident fish, and wildlife in the Columbia River Basin (Basin). The comments received after the meeting were favorable and the participants agreed that the meeting was stimulating and productive. The information exchanged should lead to better coordination with other projects throughout the Basin. The following pages list the projects by title, the project leaders and BPA's project officers, and an abstract of each leaders presentation. These summaries are in some cases preliminary; they are subject to change and should not be quoted without consulting the project leader.

  7. Will the Occupational Safety and Health Administration's Proposed Standards for Occupational Exposure to Respirable Crystalline Silica Reduce Workplace Risk?

    PubMed

    Dudley, Susan E; Morriss, Andrew P

    2015-07-01

    The Occupational Safety and Health Administration (OSHA) is developing regulations to amend existing standards for occupational exposure to respirable crystalline silica by establishing a new permissible exposure limit as well as a series of ancillary provisions for controlling exposure. This article briefly reviews OSHA's proposed regulatory approach and the statutory authority on which it is based. It then evaluates OSHA's preliminary determination of significant risk and its analysis of the risk reduction achievable by its proposed controls. It recognizes that OSHA faces multiple challenges in devising a regulatory approach that reduces exposures and health risks and meets its statutory goal. However, the greatest challenge to reducing risks associated with silica exposure is not the lack of incentives (for either employers or employees) but rather lack of information, particularly information on the relative toxicity of different forms of silica. The article finds that OSHA's proposed rule would contribute little in the way of new information, particularly since it is largely based on information that is at least a decade old--a significant deficiency, given the rapidly changing conditions observed over the last 45 years. The article concludes with recommendations for alternative approaches that would be more likely to generate information needed to improve worker health outcomes. PMID:25808427

  8. Bonneville Power Administration Site Environmental Report, 1991.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-06-01

    In 1991, in order to provide BPA`s management with environmental information for decision making, and to comply with the National Environmental Policy Act (NEPA) of 1969, BPA completed 15 environmental impact evaluations and decision documents, with many more in progress. BPA received the results of two US Department of Energy (DOE) environmental management audits, which noted areas for improvement in our operations. We completed Action Plans in response to each DOE report. We received one administrative complaint from the US Environmental Protection Agency (EPA) concerning a 1990 spill in Arlington, Oregon, caused by a BPA subcontractor. BPA responded promptly to EPA`s findings and concerns. There were 32 new spill/release incidents, most involving failure of Polychlorinated biphenyl (PCB) capacitors. Cleanup of these spills/releases has proceeded satisfactorily. BPA continued vigorous efforts to clean up substations contaminated with residuals of oil and PCB from past spills. BPA took several actions to improve our environmental performance with respect to water quality. The BPA environmental team developed a long-term schedule for environmental appraisals and audits, identifying facilities and projects that will receive audits through 1996.

  9. Bonneville Power Administration 1991 site environmental report

    SciTech Connect

    Not Available

    1992-06-01

    In 1991, in order to provide BPA's management with environmental information for decision making, and to comply with the National Environmental Policy Act (NEPA) of 1969, BPA completed 15 environmental impact evaluations and decision documents, with many more in progress. BPA received the results of two US Department of Energy (DOE) environmental management audits, which noted areas for improvement in our operations. We completed Action Plans in response to each DOE report. We received one administrative complaint from the US Environmental Protection Agency (EPA) concerning a 1990 spill in Arlington, Oregon, caused by a BPA subcontractor. BPA responded promptly to EPA's findings and concerns. There were 32 new spill/release incidents, most involving failure of Polychlorinated biphenyl (PCB) capacitors. Cleanup of these spills/releases has proceeded satisfactorily. BPA continued vigorous efforts to clean up substations contaminated with residuals of oil and PCB from past spills. BPA took several actions to improve our environmental performance with respect to water quality. The BPA environmental team developed a long-term schedule for environmental appraisals and audits, identifying facilities and projects that will receive audits through 1996.

  10. Direct Loans. An Assessment of the Clinton Administration's Proposals and Some Suggestions for Improvement. AGB Public Policy Series, No. 93-1.

    ERIC Educational Resources Information Center

    Hauptman, Arthur M.

    1993-01-01

    In 1992 the Clinton Administration proposed phasing out the federally guaranteed student loan program and replacing it with a direct lending program run entirely by the federal government, claiming that this approach would save taxpayer money and simplify a complex program. Opponents of the Administration plan argued instead for changes in federal…

  11. Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation

    PubMed Central

    McCaffrey, Katherine A.; Jones, Brian; Mabrey, Natalie; Weiss, Bernard; Swan, Shanna H.; Patisaul, Heather B.

    2013-01-01

    Bisphenol A (BPA) is a high volume production chemical used in polycarbonate plastics, epoxy resins, thermal paper receipts, and other household products. The neural effects of early life BPA exposure, particularly to low doses administered orally, remain unclear. Thus, to better characterize the dose range over which BPA alters sex specific neuroanatomy, we examined the impact of perinatal BPA exposure on two sexually dimorphic regions in the anterior hypothalamus, the sexually dimorphic nucleus of the preoptic area (SDN-POA) and the anterioventral periventricular (AVPV) nucleus. Both are sexually differentiated by estradiol and play a role in sex specific reproductive physiology and behavior. Long Evans rats were prenatally exposed to 10, 100, 1000, 10,000 mg/kg bw/day BPA through daily, noninvasive oral administration of dosed-cookies to the dams. Offspring were reared to adulthood. Their brains were collected and immunolabeled for tyrosine hydroxylase (TH) in the AVPV and calbindin (CALB) in the SDN-POA. We observed decreased TH-ir cell numbers in the female AVPV across all exposure groups, an effect indicative of masculinization. In males, AVPV TH-ir cell numbers were significantly reduced in only the BPA 10 and BPA 10,000 groups. SDN-POA endpoints were unaltered in females but in males SDN-POA volume was significantly lower in all BPA exposure groups. CALB-ir was significantly lower in all but the BPA 1000 group. These effects are consistent with demasculinization. Collectively these data demonstrate that early life oral exposure to BPA at levels well below the current No Observed Adverse Effect Level (NOAEL) of 50 mg/kg/day can alter sex specific hypothalamic morphology in the rat. PMID:23500335

  12. 77 FR 66966 - Fiscal Year (FY) 2014-2015 Proposed Power and Transmission Rate Adjustments; Public Hearing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... (BPA or Bonneville), Department of Energy (DOE). ACTIONS: Notice of FY 2014-2015 Proposed Power and Transmission Rate Adjustments. SUMMARY: BPA is holding a consolidated rate proceeding, Docket No. BP- 14, to... Conservation Act (Northwest Power Act) provides that BPA must establish and periodically review and revise...

  13. Non-Federal Participation Capacity Ownership : Administrator`s Final Record of Decision.

    SciTech Connect

    United States. Bonneville Power Administration.

    1994-03-01

    In a September 1988 Record of Decision (ROD), Bonneville Power Administration (BPA) explained its decision to proceed with the Third Alternating Current (Third AC) Intertie addition construction project using its own funding. At that time, BPA`s decision on non-Federal ownership access to the added capacity was deferred to a separate non-Federal participation policy development process. BPA`s preferred alternative for providing non-Federal Intertie access is to adopt Capacity Ownership for 725 MW. Capacity Ownership allows non-Federal PNW scheduling utilities to purchase contract rights to use protions of BPA`s share of AC Intertie capacity for the life of the Intertie facilities. This ROD documents BPA`s decision to proceed with Capacity Ownership for non-Federal parties.

  14. Evaluating the Impact of U.S. Food and Drug Administration-Proposed Nutrition Facts Label Changes on Young Adults' Visual Attention and Purchase Intentions

    ERIC Educational Resources Information Center

    Graham, Dan J.; Roberto, Christina A.

    2016-01-01

    Background: The U.S. Food and Drug Administration (FDA) has proposed modifying the Nutrition Facts Label (NFL) on food packages to increase consumer attention to this resource and to promote healthier dietary choices. Aims: The present study sought to determine whether the proposed NFL changes will affect consumer attention to the NFL or purchase…

  15. An oscillation detector used in the BPA power system disturbance monitor

    SciTech Connect

    Haver, J.F.; Vakili, F. )

    1990-02-01

    In 1987 an oscillation trigger was developed for the power system disturbance monitor that the Bonneville Power Administration (BPA) operates at the Dittmer Control Center. The trigger logic resembles that for extracting information from an amplitude-modulated carrier wave. Operating experience shows the trigger to be sensitive, reliable, and versatile. This paper describes the trigger and its basic principles in detail. Filter responses curves and FORTRAN source code are provided for use by utilities having similar needs.

  16. A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program.

    PubMed

    Schug, Thaddeus T; Heindel, Jerrold J; Camacho, Luísa; Delclos, K Barry; Howard, Paul; Johnson, Anne F; Aungst, Jason; Keefe, Dennis; Newbold, Retha; Walker, Nigel J; Thomas Zoeller, R; Bucher, John R

    2013-09-01

    Recently, medical research has seen a strong push toward translational research, or "bench to bedside" collaborations, that strive to enhance the utility of laboratory science for improving medical treatment. The success of that paradigm supports the potential application of the process to other fields, such as risk assessment. Close collaboration among academic, government, and industry scientists may enhance the translation of scientific findings to regulatory decision making. The National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), and U.S. Food and Drug Administration (FDA) developed a consortium-based research program to link more effectively academic and guideline-compliant research. An initial proof-of-concept collaboration, the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), uses bisphenol A (BPA) as a test chemical. The CLARITY-BPA program combines a core perinatal guideline-compliant 2-year chronic toxicity study with mechanistic studies/endpoints conducted by academic investigators. Twelve extramural grantees were selected by NIEHS through an RFA-based initiative to participate in the overall study design and conduct disease-relevant investigations using tissues and animals from the core study. While the study is expected to contribute to our understanding of potential effects of BPA, it also has ramifications beyond this specific focus. Through CLARITY-BPA, NIEHS has established an unprecedented level of collaboration among extramural grantees and regulatory researchers. By drawing upon the strengths of academic and regulatory expertise and research approaches, CLARITY-BPA represents a potential new model for filling knowledge gaps, enhancing quality control, informing chemical risk assessment, and identifying new methods or endpoints for regulatory hazard assessments. PMID:23747832

  17. Feasibility study: Application of RCM techniques for substation maintenance at the Bonneville Power Administration

    SciTech Connect

    Purucker, S.L.; Tonn, B.E.; Goeltz, R.T.; James, R.D.; Kercel, S.; Rizy, D.T.; Simpson, M.L.; Van Dyke, J.W.

    1992-05-28

    This feasibility study examines reliability centered maintenance (RCM) as it applies to Bonneville Power Administrations (BPA) substation maintenance program. Reliability techniques are examined in evaluated. Existing BPA equipment maintenance procedures are documented. Equipment failure history is considered. Economic impacts are estimated. Various equipment instrumentation methods are reviewed. Based on this analysis a prototype system is proposed. The prototype will be implemented in two phases. Phase 1 is to be completed in 1992, it includes instrumenting one power transformer and one oil circuit breaker. Software development will focus on displaying data. Phase 2 is to be completed the following year. The remaining transformers and breakers will be instrumented during the second phase. Software development will focus on predictive maintenance techniques and maintenance decision support.

  18. 29 CFR 102.42 - Filings of briefs and proposed findings with the administrative law judge and oral argument at...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the administrative law judge, who may fix a reasonable time for such filing, but not in excess of 35 days from the close of the hearing. Requests for further extensions of time shall be made to the...

  19. 2007 Wholesale Power Rate Case Initial Proposal : Wholesale Power Rate Development Study.

    SciTech Connect

    United States. Bonneville Power Administration.

    2007-11-01

    The Wholesale Power Rate Development Study (WPRDS) calculates BPA proposed rates based on information either developed in the WPRDS or supplied by the other studies that comprise the BPA rate proposal. All of these studies, and accompanying documentation, provide the details of computations and assumptions. In general, information about loads and resources is provided by the Load Resource Study (LRS), WP-07-E-BPA-01, and the LRS Documentation, WP-07-E-BPA-01A. Revenue requirements information, as well as the Planned Net Revenues for Risk (PNNR), is provided in the Revenue Requirement Study, WP-07-E-BPA-02, and its accompanying Revenue Requirement Study Documentation, WP-07-E-BPA-02A and WP-07-E-BPA-02B. The Market Price Forecast Study (MPFS), WP-07-E-BPA-03, and the MPFS Documentation, WP-07-E-BPA-03A, provide the WPRDS with information regarding seasonal and diurnal differentiation of energy rates, as well information regarding monthly market prices for Demand Rates. In addition, this study provides information for the pricing of unbundled power products. The Risk Analysis Study, WP-07-E-BPA-04, and the Risk Analysis Study Documentation, WP-07-E-BPA-04A, provide short-term balancing purchases as well as secondary energy sales and revenue. The Section 7(b)(2) Rate Test Study, WP-07-E-BPA-06, and the Section 7(b)(2) Rate Test Study Documentation, WP-07-E-BPA-06A, implement Section 7(b)(2) of the Northwest Power Act to ensure that BPA preference customers firm power rates applied to their general requirements are no higher than rates calculated using specific assumptions in the Northwest Power Act.

  20. NEPA meets government reinvention: Bonneville Power Administration`s business plan E.I.S.

    SciTech Connect

    Wolfe, D.V.; Alton, C.; Linehan, A.O.

    1995-12-01

    During the early 1990`s Bonneville Power Administration (BPA) found its role as the Pacific Northwest`s largest wholesale marketer of electric power challenged by energy market deregulation, increasing competition from utilities and non-utility power sources, and uncertainty about future costs. Moreover, the rapid decline of endangered salmon stocks appeared to be leading to significant changes in the operations of the Columbia River hydroelectric system and limitations in the amount of hydro power BPA could sell its utility customers. In response, BPA began a fundamental review of all of its power and transmission products, rates, organization, and administrative procedures. BPA`s reinvention was clearly a major Federal action subject to NEPA, and the Business Plan EIS quickly became the focus of both BPA`s effort to question the fundamental mechanisms of its operations, and of the many customers, environmental organizations, and interest groups that watchdog BPA`s activities. In developing the Business Plan EIS, BPA faced multiple challenges: (1) complex, interrelated issues, including power sales contract terms, power rates, hydroelectric operations and salmon survival, transmission system deregulation, energy resource choices, conservation program reinvention, and fish and wildlife program management reform; (2) drawing appropriate boundaries around the subject of analysis instead of letting the EIS become the {open_quotes}black hole{close_quotes} for every regional environmental issue; (3) framing and evaluating broad policy choices in an understandable and useful manner without getting lost in the detail of the myriad decisions BPA faces; (4) keeping pace with evolving management thinking about BPA`s new direction; (5) linking Business Plan choices to market responses and ultimately to environmental impacts. The Business Plan EIS is an innovative effort to address broad policy directions, marketing relationships, and environmental impacts.

  1. Chronic High Dose Intraperitoneal Bisphenol A (BPA) Induces Substantial Histological and Gene Expression Alterations in Rat Penile Tissue Without Impairing Erectile Function

    PubMed Central

    Kovanecz, Istvan; Gelfand, Robert; Masouminia, Maryam; Gharib, Sahir; Segura, Denesse; Vernet, Dolores; Rajfer, Jacob; Li, De-Kun; Liao, Chun Yang; Kannan, Kurunthachalam; Gonzalez-Cadavid, Nestor F.

    2014-01-01

    dose of BPA developed hypogonadism and a corporal histo- and molecular-pathology usually associated with ED, no changes were detected in erectile function as measured by EFS and cavernosometry. Further studies using alternate routes of BPA administration with various doses and length of exposure are needed to expand these findings. Kovanecz I, Gelfand R, Masouminia M, Gharib S, Segura D, Vernet D, Rajfer J, Li DK, Liao CY, Kannan K, and Gonzalez-Cadavid NF. Chronic high dose intraperitoneal bisphenol A (BPA) induces substantial histological and gene expression alterations in rat penile tissue without impairing erectile function. PMID:24134786

  2. The Administration's Education Reform Proposal. Hearing on Examining the Administration's Proposal To Reform the National Education System before the Committee on Labor and Human Resources. United States Senate, One Hundred Second Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    Senator Edward M. Kennedy, chairman of the committee, opened the hearing by commending President Bush and U.S. Department of Education Secretary Lamar Alexander for putting forward an education reform plan. Kennedy then stated his reservations: the plan does not devote enough attention to school readiness; the administration emphasizes choice as a…

  3. Expression of fibronectin binding protein A (FnBPA) from Staphylococcus aureus at the cell surface of Lactococcus lactis improves its immunomodulatory properties when used as protein delivery vector.

    PubMed

    Almeida, Juliana F; Breyner, Natalia M; Mahi, Miloud; Ahmed, Bensoltane; Benbouziane, Bouasria; Boas, Priscilla C B Vilas; Miyoshi, Anderson; Azevedo, Vasco; Langella, Philippe; Bermúdez-Humarán, Luis G; Chatel, Jean-Marc

    2016-03-01

    A recombinant strain of Lactococcus lactis displaying a cell-surface anchored fibronectin binding protein A (FnBPA) from Staphylococcus aureus (LL-FnBPA) had been shown to be more efficient in delivering plasmid than its wild-type counterpart both in vitro and in vivo, and have the ability to orientate the immune response toward a Th2 profile in a context of a DNA vaccination. The aim of this work was to test whether this LL-FnBPA strain could shape the immune response after mucosal administration in mice. For this, we used a mouse model of human papilloma virus (HPV)-induced cancer and a L. lactis strain displaying at its cell surface both HPV-16-E7 antigen (LL-E7) and FnBPA (LL-E7+FnBPA). Our results revealed a more efficient systemic Th1 immune response with recombinant LL-E7+FnBPA. Furthermore, mice vaccinated with LL-E7+FnBPA were better protected when challenged with HPV-16-induced tumors. Altogether, the results suggest that FnBPA displays adjuvant properties when used in the context of mucosal delivery using L. lactis as a live vector. PMID:26854905

  4. BPA Committed to Northwest Values

    SciTech Connect

    2010-09-01

    The Columbia River has been called the “crown jewel” of the Pacific Northwest. There is no question it is among the region’s greatest assets — supplying low-cost clean hydropower, making deserts bloom thanks to irrigation and providing navigation, recreation and a home for many species of fish and wildlife. The Bonneville Power Administration is proud to be a steward of this great resource. Our mission is to serve the people and environment of the Pacific Northwest. We sell wholesale power from Grand Coulee Dam and 30 other Northwest federal dams to Northwest utilities, including public utility districts, rural electric cooperatives and municipal utility departments, as well as investor-owned utilities. We operate three-fourths of the region’s high voltage transmission system that delivers that power. But, as a federal agency, we are not just a power marketer. We have public responsibilities that include, among many, promoting energy efficiency, facilitating development of renewable power, protecting fish and wildlife affected by hydro development, honoring treaty obligations to tribes and promoting a reliable energy future through collaboration and partnerships. This document describes our responsibilities to citizens in the Pacific Northwest.

  5. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false How does the Administrator provide...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the...

  6. A Comparative Study Concerning Administrative Aspects of Elementary Off-Campus Student Teaching Programs: Current Practices and Proposed Patterns.

    ERIC Educational Resources Information Center

    Armstrong, Robert J.

    A study was made to determine the current status of selected administrative areas of student teaching programs in Massachusetts and cooperative student teaching programs throughout the nation, the desirability of establishing cooperative programs in Massachusetts, and the organization and impelementation of these programs. Specific administrative…

  7. 43 CFR 404.51 - Are proposed projects under the Rural Water Supply Program reviewed by the Administration?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Are proposed projects under the Rural... Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Feasibility Studies § 404.51 Are proposed projects under the Rural Water Supply...

  8. Measurements of 10B(p,a)7Be Cross-sections: A Reaction Relevant to Nuclear Fusion Energy Research

    NASA Astrophysics Data System (ADS)

    Fisher, Barbara; Kafkarkou, Adamos; Ahmed, Mohammad; Weller, Henry; Myers, Luke; Sparker, Mark; Zimmerman, William; Mueller, Jon; Sikora, Mark; Mazumdar, Indral

    2012-10-01

    There is growing interest in aneutronic nuclear fusion reactors. One facility proposes to utilize the 11B(p,a)7Be reaction. The Radiative Capture Group at Triangle University Nuclear Laboratory (TUNL) has been engaged in a long-term study of this and related reactions. This poster will present preliminary data and analysis of the 10B(p,a)7Be reaction which is of interest because 10B is a potential reactor contaminant. Differential and total cross-sections will be presented for incident protons of 4.4 and 4.6 MeV. The data is necessary for simulations of an aneutrionic nuclear fusion reactor.

  9. A round robin approach to the analysis of bisphenol a (BPA) in human blood samples

    PubMed Central

    2014-01-01

    Background Human exposure to bisphenol A (BPA) is ubiquitous, yet there are concerns about whether BPA can be measured in human blood. This Round Robin was designed to address this concern through three goals: 1) to identify collection materials, reagents and detection apparatuses that do not contribute BPA to serum; 2) to identify sensitive and precise methods to accurately measure unconjugated BPA (uBPA) and BPA-glucuronide (BPA-G), a metabolite, in serum; and 3) to evaluate whether inadvertent hydrolysis of BPA-G occurs during sample handling and processing. Methods Four laboratories participated in this Round Robin. Laboratories screened materials to identify BPA contamination in collection and analysis materials. Serum was spiked with concentrations of uBPA and/or BPA-G ranging from 0.09-19.5 (uBPA) and 0.5-32 (BPA-G) ng/mL. Additional samples were preserved unspiked as ‘environmental’ samples. Blinded samples were provided to laboratories that used LC/MSMS to simultaneously quantify uBPA and BPA-G. To determine whether inadvertent hydrolysis of BPA metabolites occurred, samples spiked with only BPA-G were analyzed for the presence of uBPA. Finally, three laboratories compared direct and indirect methods of quantifying BPA-G. Results We identified collection materials and reagents that did not introduce BPA contamination. In the blinded spiked sample analysis, all laboratories were able to distinguish low from high values of uBPA and BPA-G, for the whole spiked sample range and for those samples spiked with the three lowest concentrations (0.5-3.1 ng/ml). By completion of the Round Robin, three laboratories had verified methods for the analysis of uBPA and two verified for the analysis of BPA-G (verification determined by: 4 of 5 samples within 20% of spiked concentrations). In the analysis of BPA-G only spiked samples, all laboratories reported BPA-G was the majority of BPA detected (92.2 – 100%). Finally, laboratories were more likely to be verified

  10. Medicaid program; relation with other agencies and miscellaneous Medicaid definitions--Health Care Financing Administration. Proposed rule.

    PubMed

    1983-03-11

    We proposed to amend the Medicaid regulations to allow States the option of paying cost sharing amounts for Medicaid beneficiaries who are covered under Medicare Part B "Buy-in" agreements. We also propose to revise several definitions and clarify ambiguities in existing Medicaid regulations. The proposed definition changes are related to private duty nursing services, inpatient psychiatric services, inpatient and outpatient and outpatient. All changes are a part of the Department's regulatory reform effort which targets for revision those regulations that are ambiguous or that have been identified as problematic. PMID:10298970

  11. Exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of ERK signal pathway.

    PubMed

    Li, Juan; Mao, Rui; Zhou, Qin; Ding, Ling; Tao, Jin; Ran, Mao-Mei; Gao, Er-Sheng; Yuan, Wei; Wang, Jin-Tao; Hou, Li-Fang

    2016-03-01

    Bisphenol A (BPA) is an estrogenic environmental toxin widely used in the production of plastics and ubiquitous human exposure to this chemical has been proposed to be a potential risk to human health. Exposure to BPA can negatively impact sperm quality. However, the mechanism remains largely unknown. The objectives of this study were to assess the role of BPA on sperm quality and explore the possible mechanisms. The Wistar male rats (aged 28 days) were administered BPA by oral gavage for 28 days at dose of 50, 100 and 200 mg/kg/day; meanwhile, the negative control with corn oil (0 mg/kg/day BPA) and positive control with E2 at the dose of 100 μg/kg/day. The sperm density, sperm activity and sperm survival rate were analyzed byCASA system, and the sperm abnormality rate was analyzed by improved Papanicolaou stained. The protein expression levels of Src/p-Src, ERK1/2, p-ERK1/2 and CREB/p-CREB were detected by Western bolt. The results showed that the body weight gain, testes weight, testis coefficient, sperm density, sperm activity, sperm survival rate and protein expression levels of p-ERK1, p-ERK2 and p-CREB decreased, but the sperm abnormality rate increased with increasing BPA concentrations. There were positive correlations between sperm density, sperm activity and sperm survival rate with protein expression levels of p-ERK1, p-ERK2 and p-CREB, and negative correlations between sperm abnormality rate with the protein expression levels of p-ERK1, p-ERK2 and p-CREB. Results from the structural equation model demonstrated that BPA retained a significant negative effect to p-ERK, whereas p-ERK retained a significant positive effect to sperm quality and acted as the mediate variable. This study provides a novel insight regarding the potential role of p-ERK1 and p-ERK2 protein kinase on reproductive toxicity of BPA. The adverse effects of BPA on adult male sperm quality may be through the induction of the disruption of ERK signal pathway. However, additional

  12. Bisphenol A (BPA) in U.S. food.

    PubMed

    Schecter, Arnold; Malik, Noor; Haffner, Darrah; Smith, Sarah; Harris, T Robert; Paepke, Olaf; Birnbaum, Linda

    2010-12-15

    Bisphenol A (BPA) is a chemical used for lining metal cans and in polycarbonate plastics, such as baby bottles. In rodents, BPA is associated with early sexual maturation, altered behavior, and effects on prostate and mammary glands. In humans, BPA is associated with cardiovascular disease, diabetes, and male sexual dysfunction in exposed workers. Food is a major exposure source. We know of no studies reporting BPA in U.S. fresh food, canned food, and food in plastic packaging in peer reviewed journals. We measured BPA levels in 105 fresh and canned foods, foods sold in plastic packaging, and in cat and dog foods in cans and plastic packaging. We detected BPA in 63 of 105 samples, including fresh turkey, canned green beans, and canned infant formula. Ninety-three of these samples were triplicates which had similar detected levels. Detected levels ranged from 0.23 to 65.0 ng/g ww and were not associated with type of food or packaging but did vary with pH. BPA levels were higher for foods of pH 5 compared to more acidic and alkaline foods. Detected levels were comparable to those found by others. Further research is indicated to determine BPA levels in U.S. food in larger, representative sampling. PMID:21038926

  13. Feasibility study: Application of RCM techniques for substation maintenance at the Bonneville Power Administration. [Reliability Centered Maintenance (RCM)

    SciTech Connect

    Purucker, S.L.; Tonn, B.E.; Goeltz, R.T.; James, R.D.; Kercel, S.; Rizy, D.T.; Simpson, M.L.; Van Dyke, J.W.

    1992-05-28

    This feasibility study examines reliability centered maintenance (RCM) as it applies to Bonneville Power Administrations (BPA) substation maintenance program. Reliability techniques are examined in evaluated. Existing BPA equipment maintenance procedures are documented. Equipment failure history is considered. Economic impacts are estimated. Various equipment instrumentation methods are reviewed. Based on this analysis a prototype system is proposed. The prototype will be implemented in two phases. Phase 1 is to be completed in 1992, it includes instrumenting one power transformer and one oil circuit breaker. Software development will focus on displaying data. Phase 2 is to be completed the following year. The remaining transformers and breakers will be instrumented during the second phase. Software development will focus on predictive maintenance techniques and maintenance decision support.

  14. 78 FR 48868 - Proposed Cercla Administrative Cost Recovery Settlement; MassDOT, MassDOT Route 1 Right-of-Way...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... AGENCY Proposed Cercla Administrative Cost Recovery Settlement; MassDOT, MassDOT Route 1 Right-of-Way...), concerning the MassDOT Route 1 Right-of-Way Site in Chelsea, Massachusetts with the following Settling Party... should refer to: In re: MassDOT Route 1 Right-of- Way Site, U.S. EPA Docket No.01-2013-0031. FOR...

  15. Biotransformation of glyceryl trinitrate (GTN) in isolated bovine pulmonary artery (BPA) and bovine pulmonary vein (BPV)

    SciTech Connect

    Not Available

    1986-03-01

    A proposed mechanism of GTN-induced vasodilation requires biotransformation of GTN to glyceryl dinitrate (GDN). They have previously shown that GTN is metabolized to GDN during relaxation of isolated rabbit aorta. The authors have extended this study to include BPA and BPV and to determine if their sensitivity to GTN correlates with their ability to metabolize GTN. Strips of BPA and BPV were contracted submaximally with KCl and then incubated with 0.5 ..mu..M /sup 14/C-GTN for 2 min. GTN-induced relaxation of these vessels was monitored and tissue GTN and metabolite concentrations were measured. Data are presented which support the above hypothesis that GTN biotransformation and relaxation occur together in vascular smooth muscle; however, there appear to be factors other than extent of GTN biotransformation that account for the difference in sensitivity to GTN of the artery and vein.

  16. Health risk of exposure to Bisphenol A (BPA).

    PubMed

    Konieczna, Aleksandra; Rutkowska, Aleksandra; Rachoń, Dominik

    2015-01-01

    Bisphenol A (BPA) belongs to chemicals that are produced in large quantities worldwide. It is commonly used as monomer in polycarbonate synthesis, plasticizer in the production of epoxy resins, as well as an additive for the elimination of surfeit of hydrochloric acid during the polyvinyl chloride (PVC) production. BPA is not only used in the production of plastics intended to a direct contact with food, including plastic packaging and kitchenware, but also in inner coatings of cans and jar caps. There are various routes of human exposure to this substance such as oral, by inhalation and transdermal. The main sources of exposure to BPA include food packaging and dust, dental materials, healthcare equipment, thermal paper, toys and articles for children and infants. BPA is metabolized in the liver to form bisphenol A glucuronide and mostly in this form is excreted with urine. Due to its phenolic structure BPA has been shown to interact with estrogen receptors and to act as agonist or antagonist via estrogen receptor (ER) dependent signalling pathways. Therefore, BPA has been shown to play a role in the pathogenesis of several endocrine disorders including female and male infertility, precocious puberty, hormone dependent tumours such as breast and prostate cancer and several metabolic disorders including polycystic ovary syndrome (PCOS). Because of the constant, daily exposure and its tendency to bio-accumulation, BPA seems to require special attention such as biomonitoring. This observation should include clinical tests of BPA concentration in the urine, which is not only one of the best methods of evaluation of the exposure to this compound, but also the dependence of the daily intake of BPA and the risk of some endocrine disorders. PMID:25813067

  17. BPA uptake in rat tissues after partial hepatectomy

    SciTech Connect

    Slatkin, D.N.; Nawrocky, M.M.; Coderre, J.A.; Fisher, C.D.; Joel, D.D.; Lombardo, D.T.; Micca, P.L.

    1996-12-31

    In boron neutron capture therapy (BNCT), boron given as boronophenylalanine (BPA) accumulates transiently not only in tumors but also in normal tissues. Average boron concentrations in transplanted 9L gliosarcoma tumors of 20 rats were 2.5 to 3.7 times concentrations found in blood. Although boron levels in a variety of tissues were also higher than blood the concentrations were less than the lowest found in the tumor. Further note than although BPA is a structural analogue of phenylalanine (Phe), the pathway of BPA uptake into regenerating liver may not be linked to Phe uptake mechanisms.

  18. Bonneville Power Administration 1997 Annual Report.

    SciTech Connect

    United States. Bonneville Power Administration.

    1998-01-01

    The Bonneville Power Administration`s 60th anniversary year exceeded expectations. Net revenues were the best since 1991, which demonstrates that earlier decisions to transform BPA into a smaller, cost-conscious, customer-focused organization were the correct decisions. The region`s evaluation of the agency`s role in the Northwest was as gratifying as the positive financial position. Through the Comprehensive Review of the Northwest Energy System, the region concluded that BPA has been and must continue to be an important economic and environmental benefit to the Northwest. BPA occupies a unique position in the region that is crystallized in the agency`s new purpose statement: to meet their public responsibilities through commercially successful businesses. The agency must be commercially successful to provide funding for public responsibilities such as its fish and wildlife program, conservation, and reliable power and transmission systems. But the heart and soul of the agency is providing benefits that reflect the public service orientation that inspired the agency`s creation 60 years ago. BPA will provide the region with power at cost, provide preference to the region because the river on which the hydro system is based is a regional resource, and continue to see that its power flows to the little guys. It is just as important that BPA deliver power to the region`s residential and rural consumers now as it was when the agency brought electricity to rural areas for the first time.

  19. ORAL BISPHENOL A (BPA) GIVEN TO RATS AT MODERATE DOSES IS ASSOCIATED WITH ERECTILE DYSFUNCTION, CAVERNOSAL LIPOFIBROSIS, AND ALTERATIONS OF GLOBAL GENE TRANSCRIPTION

    PubMed Central

    Kovanecz, I; Gelfand, R; Masouminia, M; Gharib, S; Segura, D; Vernet, D; Rajfer, J; Li, DK; Kannan, K; Gonzalez-Cadavid, NF

    2013-01-01

    Introduction Bisphenol A (BPA), a suspected reproductive biohazard and endocrine disruptor released from plastics is associated with erectile dysfunction (ED) in occupationally exposed workers. However, in rats, despite the induction of hypogonadism, apoptosis of the penile corporal smooth muscle, fat infiltration into the cavernosal tissue, and changes in global gene expression with the intraperitoneal administration of high dose BPA, ED was not observed. Aims We investigated whether BPA administered orally rather than intraperitoneally to rats for longer periods and lower doses will lead to ED. Main Outcomes Measures ED, histological, and biochemical markers in rat penile tissues. Methods 2.5-month old rats were given drinking water daily without and with BPA at 1 and 0.1 mg/kg/day. Two months later, erectile function was determined by cavernosometry (DIC) and electrical field stimulation (EFS) and serum levels of testosterone (T), estradiol (E2), and BPA were measured. Penile tissue sections were assayed by Masson (smooth muscle (SM)/collagen), Oil Red O (fat), TUNEL (apoptosis), immunohistochemistry for Oct 4 (stem cells), and α-SM actin/ calponin (SM and myofibroblasts), applying quantitative image analysis. Other markers were assayed by western blots. DNA microarrays/microRNA assays defined transcription profiles. Results Orally administered BPA did not affect body weight, but: 1) decreased serum T and E2; 2) reduced the EFS response and increased the DIC drop rate; 3) increased within the corporal tissue the presence of fat, myofibroblasts and apoptosis; 4) lowered the contents of SM and stem cells, but not nerve terminals; and 5) caused alterations of the transcriptional profiles for both mRNA and microRNAs within the penile shaft. Conclusions Long-term exposure of rats to oral BPA,caused a moderate corporal veno-occlusive dysfunction (CVOD), possibly due to alterations within the corporal tissue that pose gene transcriptional changes related to

  20. From BPA to its analogues: Is it a safe journey?

    PubMed

    Usman, Afia; Ahmad, Masood

    2016-09-01

    Bisphenol-A (BPA) is one of the most abundant synthetic chemicals in the world due to its uses in plastics. Its widespread exposure vis-a-vis low dose effects led to a reduction in its safety dose and imposition of ban on its use in infant feeding bottles. This restriction paved the way for the gradual market entry of its analogues. However, their structural similarity to BPA has put them under surveillance for endocrine disrupting potential. The application of these analogues is increasing and so are the studies reporting their toxicity. This review highlights the reasons which led to the ban of BPA and also reports the exposure and toxicological data available on its analogues. Hence, this compilation is expected to answer in a better way whether the replacement of BPA by these analogues is safer or more harmful? PMID:27262103

  1. Bonneville, Power Administration Timing System

    NASA Technical Reports Server (NTRS)

    Martin, Kenneth E.

    1996-01-01

    Time is an integral part of the Bonneville Power Administration's (BPA) operational systems. Generation and power transfers are planned in advance. Utilities coordinate with each other by making these adjustments on a timed schedule. Price varies with demand, so billing is based on time. Outages for maintenance are scheduled to assure they do not interrupt reliable power delivery. Disturbance records are aligned with recorded timetags for analysis and comparison with related information. Advanced applications like traveling wave fault location and real-time phase measurement require continuous timing with high precision. Most of BPA is served by a Central Time System (CTS) at the Dittmer Control Center near Portland, OR. This system keeps time locally and supplies time to both the control center systems and field locations via a microwave signal. It is kept synchronized to national standard time and coordinated with interconnected utilities. It is the official BPA time. Powwer system control and operation is described, followed by a description of BPA timing systems including CTS, the Fault Location Acquisition Reporter, time dissemination, and phasor measurements. References are provided for further reading.

  2. Design of Studies for Development of BPA Fish and Wildlife Mitigation Accounting Policy Phase II, Volume I, 1985-1988 Summary Report.

    SciTech Connect

    Kneese, Allen V.

    1988-08-01

    As the mitigation prescribed by the Regional Act proceeds, the incremental costs of corrective measures to lessen the environmental impacts of the hydroelectric system are expected to increase and difficult questions to arise about the costs, effectiveness, and justification of alternative measures and their systemwide implications. It was deemed prudent by the BPA to anticipate this situation by launching a forward-looking research program aimed at providing methodological tools and data suitable for estimating the productivity and cost implications of mitigation alternatives in a timely manner with state-of-the-art accuracy. In this spirit, Resources for the Future (RFF) agreed at the request of the BPA to develop a research program which would provide an analytical system designed to assist the BPA Administrator and other interested and responsible parties in evaluating the ecological and economic aspects of alternative protection, enhancement, and mitigation measures. 12 refs., 4 figs., 1 tab.

  3. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure--Department of Labor. Notice of proposed rulemaking.

    PubMed

    1998-09-01

    This document contains a proposed regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). This proposed regulation would establish new standards for the processing of group health disability, pension, and other employee benefit plan claims filed by participants and beneficiaries. In the case of group health plans, as well as certain plans providing disability benefits, the new standards are intended to ensure more timely benefit determinations, improved access to information on which a benefit determination is made, and greater assurance that participants and beneficiaries will be afforded a full and fair review of denied claims. If adopted as final, the proposed regulation would affect participants and beneficiaries of employee benefit plans, plan, fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans. PMID:10185189

  4. Bonneville Power Administration 1991 Annual Report.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-01-01

    Congress enacted the Bonneville Project Act in 1937, creating the Bonneville Power Administration to market and transmit the power produced by Bonneville Dam on the Columbia River. Since then, Congress has directed BPA to sell at wholesale the power produced at a total of 30 Federal dams in the Pacific Northwest, and to acquire conservation and generating resources sufficient to meet the needs of BPA`s customer utilities. The dams and the electrical system are known as the Federal Columbia River Power System. Bonneville sells wholesale power to public and private utilities, rural cooperatives, large industries, and Federal agencies. BPA also sells or exchanges power with utilities in California. BPA uses revenues from the sale of power and transmission services to recover its own expenses, to repay the Federal investment in the power system, and to pay for the resources it has acquired. BPA pays for operation and maintenance expenses at the Federal dams and at non-Federal power plants. It also pays for irrigation benefits of Federal projects allocated to power to repay, and for fish and wildlife projects which offset damage to these resources by the Federal hydropower system. This document is the 1991 statement of budget, financial statement, cash flows, capitalization, expenses, and projects. An organization chart is included.

  5. Wide-Area Energy Storage and Management system to Balance Intermittent Resources in the Bonneville Power Administration and California ISO Control Areas

    SciTech Connect

    Makarov, Yuri V.; Yang, Bo; DeSteese, John G.; Lu, Shuai; Miller, Carl H.; Nyeng, Preben; Ma, Jian; Hammerstrom, Donald J.; Vishwanathan, Vilanyur V.

    2008-06-30

    The entire project addresses the issue of mitigating additional intermittency and fast ramps that occur at higher penetration of intermittent resources, including wind genera-tion, in the Bonneville Power Administration (BPA) and the California Independent Sys-tem Operator (California ISO) control areas. The proposed Wide Area Energy Storage and Management System (WAEMS) will address the additional regulation requirement through the energy exchange between the participating control areas and through the use of energy storage and other generation resources. For the BPA and California ISO control centers, the new regulation service will look no different comparing with the traditional regulation resources. The proposed project will benefit the regulation service in these service areas, regardless of the actual degree of penetration of the intermittent resources in the regions. The project develops principles, algorithms, market integration rules, functional de-sign and technical specifications for the WAEMS system. The project is sponsored by BPA and supported in kind by California ISO, Beacon Power Corporation, and the Cali-fornia Energy Commission (CEC).

  6. Enhanced removal of aqueous BPA model compounds using Metalloligs.

    PubMed

    Franz, Douglas M; Martin, Dean F

    2014-01-01

    A model compound, 4-(t-butyl)phenol, was used as a substitute for BPA (bisphenol acetone or Bisphenol A) a material used for the production of a large volume of common plastics. Unfortunately, BPA is suspected to have estrogenic properties, and there is a suspicion that even small amounts can have a deleterious effect against humans, especially female infants. The model compound has some similarities to BPA, but lacks some of the serious properties of BPA dust. Since other workers have demonstrated the capability of removing BPA from plastics by extraction with saline or alcohol, we studied whether Octolig, a polyethylenediimine supported on silica gel, or transition metal derivatives of Octolig could be used to remove concentrations for model compounds from aqueous solution. Octolig gave modest results 20%, the manganese (II) and iron (III) derivatives gave poor results, Cuprilig was an improvement over those two Metalloligs, but the cobalt(II) derivative was able to remove up to 56% of the model compound. Two methods were studied, batch and column chromatography. Under the conditions used in this study, the batch method was superior. PMID:24279622

  7. Toxicokinetics of bisphenol A in female DA/Han rats after a single i.v. and oral administration.

    PubMed

    Upmeier, A; Degen, G H; Diel, P; Michna, H; Bolt, H M

    2000-10-01

    Bisphenol A [BPA; 2,2-bis-(4-hydroxyphenyl)-propane] is a monomer used in the manufacture of resins with a wide range of applications, e.g. plastic coatings in the food packaging industry. BPA has been shown to have a weak oestrogenic activity in vitro and in vivo. Despite its low oestrogenic potency there is concern that, as a consequence of slow clearance, BPA might reach biologically significant levels in humans and animals exposed to environmental levels. To address this concern, we assessed the kinetic behaviour of BPA in female DA/Han rats. Groups of female rats received 10 mg BPA/kg body weight intravenously or 10 or 100 mg BPA/kg body weight orally (by gavage). Blood samples were collected at different time-points and plasma was prepared. Free BPA in the samples was isolated by fluid-fluid extraction. BPA was measured by GC-MS which allowed the reliable determination of BPA concentrations as low as approximately 10 ng/ml plasma. Immediately after i.v. administration, the BPA plasma concentration was in the range of about 15 microg/ml and decreased rapidly within the first hour (to 700 ng/ml). The levels declined further (100 ng/ml at 2 h), and after 24 h the analytical detection limit was reached. BPA was detected in plasma as early as 10 min after gavage administration, indicating rapid initial uptake from the gastrointestinal tract. Absorption of BPA was variable. In animals receiving 10 mg/kg, maximal plasma levels were reached after 1.5 h (31 ng/ ml) and 6 h (40 ng/ml). In animals receiving 100 mg/kg, plasma levels reached maxima around 30 min (150 ng/ml) and 3 h (134 ng/ml) after administration. After 48 h BPA was at or below the detection limit in both dose groups. Fluctuations in the BPA plasma concentrations over time point to the possibility of enterohepatic recirculation and protracted absorption from the gastrointestinal tract. Using the area under the concentration-time curves (AUCs), low bioavailabilities of 16.4% and 5.6% were calculated for

  8. BPA Instream Habitat Projects Completed within Asotin Creek Watershed, 1999-2001 Final Report.

    SciTech Connect

    Johnson, Bradley J.

    2002-10-23

    The Asotin County Conservation District (ACCD) is the primary entity coordinating habitat projects on both private and public lands within the Asotin Creek watershed. The watershed covers approximately 325 square miles in the Blue Mountains of southeastern Washington in WRIA 35. According to WDFW's Priority WRIA's by At-Risk Stock Significance Map, it is the highest priority WRIA in southeastern WA. Summer steelhead, bull trout, and Snake River spring chinook salmon which are listed under the Endangered Species Act (ESA), are present in the watershed. WDFW manages it as a Wild Steelhead Reserve, because no hatchery fish have been released here since 1997. The ACCD has been working with landowners, Bonneville Power Administration (BPA), Washington State Conservation Commission (WCC), Natural Resource Conservation Service (NRCS), Washington Department of Fish and Wildlife (WDFW), U.S. Forest Service, Pomeroy Ranger District (USFS), Nez Perce Tribe (NPT), Department of Ecology (DOE), National Marine Fisheries Service (NMFS), and U.S. Fish and Wildlife Service (USFWS) to address habitat projects in Asotin County. Local students, volunteers and Salmon Corps Members have been instrumental in the success of the Model Watershed Program on Asotin Creek. ACCD began coordinating habitat projects in 1995 with the help of BPA funding. Approximately two hundred seventy-six projects have been implemented as of 1999. The Washington State Legislature was successful in securing funding for endangered salmon and steelhead recovery throughout the State in 1998. While these issues were new to most of the State, southeastern Washington had been dealing with endangered fall and spring chinook salmon since 1994. The Asotin Creek In-Stream Habitat Project teamed BPA and Governor's Salmon Recovery Funding on four instream habitat projects in the Asotin Creek Watershed. These projects provide complex instream habitat for steelhead, bull trout and spring chinook in the stream. 38 pools were

  9. Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure

    PubMed Central

    vom Saal, Frederick S.; Welshons, Wade V.

    2016-01-01

    There is extensive evidence that bisphenol A (BPA) is related to a wide range of adverse health effects based on both human and experimental animal studies. However, a number of regulatory agencies have ignored all hazard findings. Reports of high levels of unconjugated (bioactive) serum BPA in dozens of human biomonitoring studies have also been rejected based on the prediction that the findings are due to assay contamination and that virtually all ingested BPA is rapidly converted to inactive metabolites. NIH and industry-sponsored round robin studies have demonstrated that serum BPA can be accurately assayed without contamination, while the FDA lab has acknowledged uncontrolled assay contamination. In reviewing the published BPA biomonitoring data, we find that assay contamination is, in fact, well controlled in most labs, and cannot be used as the basis for discounting evidence that significant and virtually continuous exposure to BPA must be occurring from multiple sources. PMID:25304273

  10. Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure.

    PubMed

    vom Saal, Frederick S; Welshons, Wade V

    2014-12-01

    There is extensive evidence that bisphenol A (BPA) is related to a wide range of adverse health effects based on both human and experimental animal studies. However, a number of regulatory agencies have ignored all hazard findings. Reports of high levels of unconjugated (bioactive) serum BPA in dozens of human biomonitoring studies have also been rejected based on the prediction that the findings are due to assay contamination and that virtually all ingested BPA is rapidly converted to inactive metabolites. NIH and industry-sponsored round robin studies have demonstrated that serum BPA can be accurately assayed without contamination, while the FDA lab has acknowledged uncontrolled assay contamination. In reviewing the published BPA biomonitoring data, we find that assay contamination is, in fact, well controlled in most labs, and cannot be used as the basis for discounting evidence that significant and virtually continuous exposure to BPA must be occurring from multiple sources. PMID:25304273

  11. Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis.

    PubMed

    Yang, Feng-Yi; Lin, Yi-Li; Chou, Fong-In; Lin, Yu-Chuan; Hsueh Liu, Yen-Wan; Chang, Lun-Wei; Hsieh, Yu-Ling

    2014-01-01

    The blood-brain barrier (BBB) can be transiently disrupted by focused ultrasound (FUS) in the presence of microbubbles for targeted drug delivery. Previous studies have illustrated the pharmacokinetics of drug delivery across the BBB after sonication using indirect visualization techniques. In this study, we investigated the in vivo extracellular kinetics of boronophenylalanine-fructose (BPA-f) in glioma-bearing rats with FUS-induced BBB disruption by microdialysis. After simultaneous intravenous administration of BPA and FUS exposure, the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. With FUS, the mean peak concentration of BPA-f in the glioma dialysate was 3.6 times greater than without FUS, and the area under the concentration-time curve was 2.1 times greater. This study demonstrates that intracerebral microdialysis can be used to assess local BBB transport profiles of drugs in a sonicated site. Applying microdialysis to the study of metabolism and pharmacokinetics is useful for obtaining selective information within a specific brain site after FUS-induced BBB disruption. PMID:24936788

  12. AIDS Prevention: Views on the Administration's Budget Proposals. Briefing Report to the Chairman, Subcommittee on Labor, Health and Human Services, Education and Related Agencies, Committee on Appropriations, United States Senate.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Div. of Human Resources.

    The General Accounting Office (GAO) conducted a study in response to Senator Lawton Chiles' request that the GAO explore the adequacy of the funding levels proposed for the Department of Health and Human Services' Public Health Service and the appropriateness of priorities reflected in the administration's proposed budget for prevention of…

  13. Removal of bisphenol A (BPA) from water by various nanofiltration (NF) and reverse osmosis (RO) membranes.

    PubMed

    Yüksel, Suna; Kabay, Nalan; Yüksel, Mithat

    2013-12-15

    The removal of an endocrine disrupting compound, bisphenol A (BPA), from model solutions by selected nanofiltration (NF) and reverse osmosis (RO) membranes was studied. The commercially available membranes NF 90, NF 270, XLE BWRO, BW 30 (Dow FilmTech), CE BWRO and AD SWRO (GE Osmonics) were used to compare their performances for BPA removal. The water permeability coefficients, rejection of BPA and permeate flux values were calculated for all membranes used. No significant changes in their BPA removal were observed for all tight polyamide based NF and RO membranes tested except for loose NF 270 membrane. The polyamide based membranes exhibited much better performance than cellulose acetate membrane for BPA removal. Almost a complete rejection (≥ 98%) for BPA was obtained with three polyamide based RO membranes (BW 30, XLE BWRO and AD SWRO). But cellulose acetate based CE BWRO membrane offered a low and variable (10-40%) rejection for BPA. PMID:23731784

  14. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

    SciTech Connect

    United States. Bonneville Power Administration.

    1994-01-01

    In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

  15. 75 FR 78690 - Fiscal Year (FY) 2012-2013 Proposed Transmission Rate Adjustments Public Hearing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ...BPA is holding a consolidated rate proceeding, Docket No. BP- 12, to establish power and transmission rates for FY 2012-2013. The purpose of this Federal Register Notice is to provide notice of the proposed rates for transmission and for the two required ancillary services (listed below, part IV.C.). BPA has previously issued a separate Federal Register Notice to provide notice of the proposed......

  16. 2007 Wholesale Power Rate Case Initial Proposal : Risk Analysis Study.

    SciTech Connect

    United States. Bonneville Power Administration.

    2005-11-01

    The Federal Columbia River Power System (FCRPS), operated on behalf of the ratepayers of the PNW by BPA and other Federal agencies, faces many uncertainties during the FY 2007-2009 rate period. Among these uncertainties, the largest revolve around hydro conditions, market prices and river operations for fish recovery. In order to provide a high probability of making its U.S. Treasury payments, BPA performs a Risk Analysis as part of its rate-making process. In this Risk Analysis, BPA identifies key risks, models their relationships, and then analyzes their impacts on net revenues (total revenues less expenses). BPA subsequently evaluates in the ToolKit Model the Treasury Payment Probability (TPP) resulting from the rates, risks, and risk mitigation measures described here and in the Wholesale Power Rate Development Study (WPRDS). If the TPP falls short of BPA's standard, additional risk mitigation revenues, such as PNRR and CRAC revenues are incorporated in the modeling in ToolKit until the TPP standard is met. Increased wholesale market price volatility and six years of drought have significantly changed the profile of risk and uncertainty facing BPA and its stakeholders. These present new challenges for BPA in its effort to keep its power rates as low as possible while fully meeting its obligations to the U.S. Treasury. As a result, the risk BPA faces in not receiving the level of secondary revenues that have been credited to power rates before receiving those funds is greater. In addition to market price volatility, BPA also faces uncertainty around the financial impacts of operations for fish programs in FY 2006 and in the FY 2007-2009 rate period. A new Biological Opinion or possible court-ordered change to river operations in FY 2006 through FY 2009 may reduce BPA's net revenues included Initial Proposal. Finally, the FY 2007-2009 risk analysis includes new operational risks as well as a more comprehensive analysis of non-operating risks. Both the operational

  17. THE ESTROGENIC ENDOCRINE DISRUPTING CHEMICAL BISPHENOL A (BPA) AND OBESITY

    PubMed Central

    vom Saal, Frederick S.; Nagel, Susan C.; Coe, Benjamin L.; Angle, Brittany M.; Taylor, Julia A.

    2012-01-01

    There is increasing experimental and epidemiological evidence that fetal programming of genetic systems is a contributing factor in the recent increase in adult obesity and other components of metabolic syndrome. In particular, there is evidence that epigenetic changes associated with the use of manmade chemicals may interact with other factors that influence fetal and postnatal growth in contributing to the current obesity epidemic. The focus of this review is on the developmental effects of estrogenic endocrine disrupting chemicals (EDCs), and more specifically on effects of exposure to the estrogenic EDC bisphenol A (BPA), on adipocytes and their function, and the ultimate impact on adult obesity; BPA exposure also results in impaired reproductive capacity. We discuss the interaction of EDCs with other factors that impact growth during fetal and neonatal life, such as placental blood flow and nutrient transport to fetuses, and how these influence fetal growth and abnormalities in homeostatic control systems required to maintain normal body weight throughout life. PMID:22249005

  18. Enantioselective synthesis of L-(-)-4- boronophenylalanine (L-BPA)

    DOEpatents

    Samsel, Edward G.

    1992-01-01

    A method of making substantially pure L-BPA is disclosed. The method includes the steps of reacting 4-bromobenzaldehyde with ethylene glycol to form 4-bromobenzaldehyde ethylene glycol acetal, sequentially reacting 4-bromobenzaldehyde ethyleneglycol acetal with Mg to produce the Grignard reagent and thereafter reacting with tributyl borate and then converting to an acid environment to form 4-boronobenzaldehyde, reacting 4-boronobenzaldehyde with diethanol amine to form 4-boronobenzaldehyde diethanolamine ester, condensing the 4-boronobenzaldehyde diethanolamine ester with 2-phenyl-2-oxazolin-5-one to form an azlactone, reacting the azlactone with an alkali metal hydroxide to form z-.alpha.-benzoylamino-4-boronocinnamic acid, asymmetrically hydrogenating the z-.alpha.-benzoylamino-4-boronocinnamic acid in the presence of a catalyst of a cheltate complex of rhodium (I) with chiral bisphosphines to form L-(+)-N-benzoyl-4-boronophenylalanine, and thereafter acidifying the L-(+)-N-benzoyl-4-boronophenylalanine in an organic medium to produce L-BPA.

  19. Enantioselective synthesis of L-(-)-4- boronophenylalanine (L-BPA)

    DOEpatents

    Samsel, E.G.

    1992-10-20

    A method of making substantially pure L-BPA is disclosed. The method includes the steps of reacting 4-bromobenzaldehyde with ethylene glycol to form 4-bromobenzaldehyde ethylene glycol acetal, sequentially reacting 4-bromobenzaldehyde ethyleneglycol acetal with Mg to produce the Grignard reagent and thereafter reacting with tributyl borate and then converting to an acid environment to form 4-boronobenzaldehyde, reacting 4-boronobenzaldehyde with diethanol amine to form 4-boronobenzaldehyde diethanolamine ester, condensing the 4-boronobenzaldehyde diethanolamine ester with 2-phenyl-2-oxazolin-5-one to form an azlactone, reacting the azlactone with an alkali metal hydroxide to form z-[alpha]-benzoylamino-4boronocinnamic acid, asymmetrically hydrogenating the z-[alpha]-benzoylamino-4-boronocinnamic acid in the presence of a catalyst of a cheltate complex of rhodium (I) with chiral bisphosphines to form L-(+)-N-benzoyl-4-boronophenylalanine, and thereafter acidifying the L-(+)-N-benzoyl-4-boronophenylalanine in an organic medium to produce L-BPA. 3 figs.

  20. Developmental programming: interaction between prenatal BPA exposure and postnatal adiposity on metabolic variables in female sheep.

    PubMed

    Veiga-Lopez, Almudena; Moeller, Jacob; Sreedharan, Rohit; Singer, Kanakadurga; Lumeng, Carey; Ye, Wen; Pease, Anthony; Padmanabhan, Vasantha

    2016-02-01

    Among potential contributors for the increased incidence of metabolic diseases is the developmental exposure to endocrine-disrupting chemicals such as bisphenol A (BPA). BPA is an estrogenic chemical used in a variety of consumer products. Evidence points to interactions of BPA with the prevailing environment. The aim of this study was to assess the effects of prenatal exposure to BPA on postnatal metabolic outcomes, including insulin resistance, adipose tissue distribution, adipocyte morphometry, and expression of inflammatory markers in adipose tissue as well as to assess whether postnatal overfeeding would exacerbate these effects. Findings indicate that prenatal BPA exposure leads to insulin resistance in adulthood in the first breeder cohort (study 1), but not in the second cohort (study 2), which is suggestive of potential differences in genetic susceptibility. BPA exposure induced adipocyte hypertrophy in the visceral fat depot without an accompanying increase in visceral fat mass or increased CD68, a marker of macrophage infiltration, in the subcutaneous fat depot. Cohens effect size analysis found the ratio of visceral to subcutaneous fat depot in the prenatal BPA-treated overfed group to be higher compared with the control-overfed group. Altogether, these results suggest that exposure to BPA during fetal life at levels found in humans can program metabolic outcomes that lead to insulin resistance, a forerunner of type 2 diabetes, with postnatal obesity failing to manifest any interaction with prenatal BPA relative to insulin resistance and adipocyte hypertrophy. PMID:26646100

  1. Precise time dissemination and applications development on the Bonneville Power Administration system

    NASA Technical Reports Server (NTRS)

    Martin, Ken E.; Esztergalyos, J.

    1992-01-01

    The Bonneville Power Administration (BPA) uses IRIG-B transmitted over microwave as its primary system time dissemination. Problems with accuracy and reliability have led to ongoing research into better methods. BPA has also developed and deployed a unique fault locator which uses precise clocks synchronized by a pulse over microwaves. It automatically transmits the data to a central computer for analysis. A proposed system could combine fault location timing and time dissemination into a Global Position System (GPS) timing receiver and close the verification loop through a master station at the Dittmer Control Center. Such a system would have many advantages, including lower cost, higher reliability, and wider industry support. Test results indicate the GPS has sufficient accuracy and reliability for this and other current timing requirements including synchronous phase angle measurements. A phasor measurement system which provides phase angle has recently been tested with excellent results. Phase angle is a key parameter in power system control applications including dynamic braking, DC modulation, remedial action schemes, and system state estimation. Further research is required to determine the applications which can most effectively use real-time phase angle measurements and the best method to apply them.

  2. Annual Review of BPA-Funded Projects in Natural and Artificial Propagation of Salmonids, March 27-29, 1985, Holiday Inn Airport, Portland, Oregon.

    SciTech Connect

    United States. Bonneville Power Administration.

    1985-04-01

    The Fish and Wildlife Division of Bonneville Power Administration (BPA) hosted a meeting for contractors to present the results of fiscal year 1984 research conducted to implement the Northwest Power Planning Council's Fish and Wildlife Program. The meeting focused on those projects specifically related to natural and artificial propagation of salmonids. The presentations were held at the Holiday Inn Airport in Portland, Oregon, on March 27-29, 1985. This document contains abstracts of the presentations from that meeting. Section 1 contains abstracts on artificial propagation, fish health, and downstream migration, and Section 2 contains abstracts on natural propagation and habitat improvement. The abstracts are indexed by BPA Project Number and by Fish and Wildlife Program Measure. The registered attendees at the meeting are listed alphabetically in Appendix A and by affiliation in Appendix B.

  3. Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta)

    USGS Publications Warehouse

    Jandegian, Caitlin M.; Deem, Sharon L.; Bhandari, Ramji K.; Holliday, Casey M.; Nicks, Diane; Rosenfeld, Cheryl S.; Selcer, Kyle; Tillitt, Donald E.; vom Saal, Fredrick S.; Velez, Vanessa; Yang, Ying; Holliday, Dawn K.

    2015-01-01

    Environmental chemicals can disrupt endocrine signaling and adversely impact sexual differentiation in wildlife. Bisphenol A (BPA) is an estrogenic chemical commonly found in a variety of habitats. In this study, we used painted turtles (Chrysemys picta), which have temperature-dependent sex determination (TSD), as an animal model for ontogenetic endocrine disruption by BPA. We hypothesized that BPA would override TSD and disrupt sexual development. We incubated farm-raised turtle eggs at the male-producing temperature (26 °C), randomly assigned individuals to treatment groups: control, vehicle control, 17β-estradiol (E2, 20 ng/g-egg) or 0.01, 1.0, 100 μg BPA/g-egg and harvested tissues at hatch. Typical female gonads were present in 89% of the E2-treated “males”, but in none of the control males (n = 35). Gonads of BPA-exposed turtles had varying amounts of ovarian-like cortical (OLC) tissue and disorganized testicular tubules in the medulla. Although the percentage of males with OLCs increased with BPA dose (BPA-low = 30%, BPA-medium = 33%, BPA-high = 39%), this difference was not significant (p = 0.85). In all three BPA treatments, SOX9 patterns revealed disorganized medullary testicular tubules and β-catenin expression in a thickened cortex. Liver vitellogenin, a female-specific liver protein commonly used as an exposure biomarker, was not induced by any of the treatments. Notably, these results suggest that developmental exposure to BPA disrupts sexual differentiation in painted turtles. Further examination is necessary to determine the underlying mechanisms of sex reversal in reptiles and how these translate to EDC exposure in wild populations.

  4. Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 3. Oral Drug Products.

    PubMed

    Allain, Leonardo; Baertschi, Steven W; Clapham, David; Foti, Chris; Lantaff, Wendy M; Reed, Robert A; Templeton, Allen C; Tønnesen, Hanne Hjorth

    2016-05-01

    The ICH Q1B guidance and additional clarifying manuscripts provide the essential information needed to conduct photostability testing for pharmaceutical drug products in the context of manufacturing, packaging, and storage. As the previous 2 papers in this series highlight for drug products administered by injection (part 1) and drug products administered via topical application (part 2), there remains a paucity of guidance and methodological approaches to conducting photostability testing to ensure effective product administration. Part 3 in the series is presented here to provide a similar approach and commentary for photostability testing for oral drug products. The approach taken, as was done previously, is to examine "worst case" photoexposure scenarios in combination with ICH-defined light sources to derive a set of practical experimental approaches to support the safe and effective administration of photosensitive oral drug products. PMID:27056630

  5. BPA-Solicited Technical Review of "Echo Meadows Project Winter Artificial Recharge: Final Report for 2001 Baseline", Technical Report 2004.

    SciTech Connect

    Morgan, David

    2004-02-01

    The purpose of this report was to provide, at BPA's request, a technical review of interim products received for Project 2001-015-00 under contract 6925. BPA sometimes solicits technical reviews for Fish and Wildlife products or issues where outside expertise is required. External review of complex project deliverables assures BPA as a funding agency that the contractor is continuing with scientifically-credible experimental techniques envisioned in the original proposal. If the project's methodology proves feasible, there could be potential applications beyond the project area to similar situations in the Columbia Basin. The Experiment involves artificial flooding during high flow periods and a determination of the portion of the return flows that end up in the Umatilla River during low flow months and within acceptable water quality parameters (e.g., low temperature, few contaminants). Flooding could be a critical water source for aquatic organisms at times of the year when flows in the lower reaches of the Umatilla River are low and water is warmer than would be desired. The experiment was proposed to test whether 'this process, recharges the shallow aquifers of the old flood plain, for natural filtration through the alluvial soils as it returns to the Umatilla River, cleaner and cooler (about 50 degree Fahrenheit) five to six month later (about July and August) substantially cooling the river and [making it] more beneficial to anadromous [fish]'. A substantial amount of preliminary data had been collected and preliminary results were submitted in an interim report 'Echo Meadows Project Winter Artificial Recharge: Final Report for 2001 Baseline (December 2002)'. A substantial amount of addition funding was provided for the last cycle of flooding (Phases II) and final analyses of the full compliment of data collected over the life of the contract (Phase III). Third party scientific review may assist the contractor in producing a higher quality Final Report with

  6. Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity-A Review.

    PubMed

    Chen, Da; Kannan, Kurunthachalam; Tan, Hongli; Zheng, Zhengui; Feng, Yong-Lai; Wu, Yan; Widelka, Margaret

    2016-06-01

    Numerous studies have investigated the environmental occurrence, human exposure, and toxicity of bisphenol A (BPA). Following stringent regulations on the production and usage of BPA, several bisphenol analogues have been produced as a replacement for BPA in various applications. The present review outlines the current state of knowledge on the occurrence of bisphenol analogues (other than BPA) in the environment, consumer products and foodstuffs, human exposure and biomonitoring, and toxicity. Whereas BPA was still the major bisphenol analogue found in most environmental monitoring studies, BPF and BPS were also frequently detected. Elevated concentrations of BPAF, BPF, and BPS (i.e., similar to or greater than that of BPA) have been reported in the abiotic environment and human urine from some regions. Many analogues exhibit endocrine disrupting effects, cytotoxicity, genotoxicity, reproductive toxicity, dioxin-like effects, and neurotoxicity in laboratory studies. BPAF, BPB, BPF, and BPS have been shown to exhibit estrogenic and/or antiandrogenic activities similar to or even greater than that of BPA. Knowledge gaps and research needs have been identified, which include the elucidation of environmental occurrences, persistence, and fate of bisphenol analogues (other than BPA), sources and pathways for human exposure, effects on reproductive systems and the mammary gland, mechanisms of toxicity from coexposure to multiple analogues, metabolic pathways and products, and the impact of metabolic modification on toxicity. PMID:27143250

  7. Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells

    PubMed Central

    Bontempo, Paola; Mita, Luigi; Doto, Antonella; Miceli, Marco; Nebbioso, Angela; Lepore, Ilaria; Franci, GianLuigi; Menafra, Roberta; Carafa, Vincenzo; Conte, Mariarosaria; De Bellis, Floriana; Manzo, Fabio; Di Cerbo, Vincenzo; Benedetti, Rosaria; D'Amato, Loredana; Marino, Maria; Bolli, Alessandro; Del Pozzo, Giovanna; Diano, Nadia; Portaccio, Marianna; Mita, Gustavo D; Vietri, Maria Teresa; Cioffi, Michele; Nola, Ernesto; Dell'Aversana, Carmela; Sica, Vincenzo; Molinari, Anna Maria; Altucci, Lucia

    2009-01-01

    Background: BPA (bisphenol A or 2,2-bis(4-hydroxy-phenol)propane) is present in the manufacture of polycarbonate plastic and epoxy resins, which can be used in impact-resistant safety equipment and baby bottles, as protective coatings inside metal food containers, and as composites and sealants in dentistry. Recently, attention has focused on the estrogen-like and carcinogenic adverse effects of BPA. Thus, it is necessary to investigate the cytotoxicity and apoptosis-inducing activity of this compound. Methods: Cell cycle, apoptosis and differentiation analyses; western blots. Results: BPA is able to induce cell cycle arrest and apoptosis in three different acute myeloid leukemias. Although some granulocytic differentiation concomitantly occurred in NB4 cells upon BPA treatment, the major action was the induction of apoptosis. BPA mediated apoptosis was caspase dependent and occurred by activation of extrinsic and intrinsic cell death pathways modulating both FAS and TRAIL and by inducing BAD phosphorylation in NB4 cells. Finally, also non genomic actions such as the early decrease of both ERK and AKT phosphorylation were induced by BPA thus indicating that a complex intersection of regulations occur for the apoptotic action of BPA. Conclusion: BPA is able to induce apoptosis in leukemia cells via caspase activation and involvement of both intrinsic and extrinsic pathways of apoptosis. PMID:19538739

  8. 48 CFR 339.7001 - Request for approval to make an award to other than a GSA BPA holder.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... make an award to other than a GSA BPA holder. 339.7001 Section 339.7001 Federal Acquisition Regulations... Services 339.7001 Request for approval to make an award to other than a GSA BPA holder. The Contracting... micro-purchase threshold, that obtaining the required services from a source other than a GSA BPA...

  9. 48 CFR 339.7001 - Request for approval to make an award to other than a GSA BPA holder.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... make an award to other than a GSA BPA holder. 339.7001 Section 339.7001 Federal Acquisition Regulations... Services 339.7001 Request for approval to make an award to other than a GSA BPA holder. The Contracting... micro-purchase threshold, that obtaining the required services from a source other than a GSA BPA...

  10. Exposure to the BPA-Substitute Bisphenol S Causes Unique Alterations of Germline Function

    PubMed Central

    Chen, Yichang; Qiu, Zhiqun; Lee, Dong Yeon; Telesca, Donatello; Yang, Xia; Allard, Patrick

    2016-01-01

    Concerns about the safety of Bisphenol A, a chemical found in plastics, receipts, food packaging and more, have led to its replacement with substitutes now found in a multitude of consumer products. However, several popular BPA-free alternatives, such as Bisphenol S, share a high degree of structural similarity with BPA, suggesting that these substitutes may disrupt similar developmental and reproductive pathways. We compared the effects of BPA and BPS on germline and reproductive functions using the genetic model system Caenorhabditis elegans. We found that, similarly to BPA, BPS caused severe reproductive defects including germline apoptosis and embryonic lethality. However, meiotic recombination, targeted gene expression, whole transcriptome and ontology analyses as well as ToxCast data mining all indicate that these effects are partly achieved via mechanisms distinct from BPAs. These findings therefore raise new concerns about the safety of BPA alternatives and the risk associated with human exposure to mixtures. PMID:27472198

  11. Exposure to the BPA-Substitute Bisphenol S Causes Unique Alterations of Germline Function.

    PubMed

    Chen, Yichang; Shu, Le; Qiu, Zhiqun; Lee, Dong Yeon; Settle, Sara J; Que Hee, Shane; Telesca, Donatello; Yang, Xia; Allard, Patrick

    2016-07-01

    Concerns about the safety of Bisphenol A, a chemical found in plastics, receipts, food packaging and more, have led to its replacement with substitutes now found in a multitude of consumer products. However, several popular BPA-free alternatives, such as Bisphenol S, share a high degree of structural similarity with BPA, suggesting that these substitutes may disrupt similar developmental and reproductive pathways. We compared the effects of BPA and BPS on germline and reproductive functions using the genetic model system Caenorhabditis elegans. We found that, similarly to BPA, BPS caused severe reproductive defects including germline apoptosis and embryonic lethality. However, meiotic recombination, targeted gene expression, whole transcriptome and ontology analyses as well as ToxCast data mining all indicate that these effects are partly achieved via mechanisms distinct from BPAs. These findings therefore raise new concerns about the safety of BPA alternatives and the risk associated with human exposure to mixtures. PMID:27472198

  12. Estrogens in the wrong place at the wrong time: fetal BPA exposure and mammary cancer

    PubMed Central

    Paulose, Tessie; Speroni, Lucia; Sonnenschein, Carlos; Soto, Ana M

    2014-01-01

    Iatrogenic gestational exposure to diethylstilbestrol (DES) induced alterations of the genital tract and predisposed individuals to develop clear cell carcinoma of the vagina as well as breast cancer later in life. Gestational exposure of rodents to a related compound, the xenoestrogen bisphenol-A (BPA) increases the propensity to develop mammary cancer during adulthood, long after cessation of exposure. Exposure to BPA during gestation induces morphological alterations in both the stroma and the epithelium of the fetal mammary gland at 18 days of age. We postulate that the primary target of BPA is the fetal stroma, the only mammary tissue expressing estrogen receptors during fetal life. BPA would then alter the reciprocal stroma-epithelial interactions that mediate mammogenesis. In addition to this direct effect on the mammary gland, BPA is postulated to affect the hypothalamus and thus in turn affect the regulation of mammotropic hormones at puberty and beyond. PMID:25277313

  13. Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original mechanism of action.

    PubMed

    Carillon, Julie; Rouanet, Jean-Max; Cristol, Jean-Paul; Brion, Richard

    2013-11-01

    Oxidative stress, involved in many diseases, is defined as an impaired balance between reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes such as superoxide dismutase (SOD) play a key role in diminishing oxidative stress. Thus, the removal of ROS by exogenous SODs could be an effective preventive strategy against various diseases. The poor bioavailability of exogenous SODs has been criticized. However, improvements in SOD formulation may overcome this limitation and boost interest in its therapeutic properties. Here, we provide a review of animal and human studies about SODs supplementation in order to evaluate their therapeutic value. Protective effects have been observed against irradiation, carcinogenesis, apoptosis and neurodegeneration. SODs administration has also been reported to alleviate inflammatory, infectious, respiratory, metabolic and cardiovascular diseases and genitourinary and fertility disorders, raising the question of its mechanism of action in these diverse situations. Some authors have shown an increase in endogenous antioxidant enzymes after exogenous SODs administration. The induction of endogenous antioxidant defence and, consequently, a decrease in oxidative stress, could explain all the effects observed. Further investigations need to be carried out to test the hypothesis that SODs supplementation acts by inducing an endogenous antioxidant defence. PMID:23793992

  14. BPA Directly Decreases GnRH Neuronal Activity via Noncanonical Pathway.

    PubMed

    Klenke, Ulrike; Constantin, Stephanie; Wray, Susan

    2016-05-01

    Peripheral feedback of gonadal estrogen to the hypothalamus is critical for reproduction. Bisphenol A (BPA), an environmental pollutant with estrogenic actions, can disrupt this feedback and lead to infertility in both humans and animals. GnRH neurons are essential for reproduction, serving as an important link between brain, pituitary, and gonads. Because GnRH neurons express several receptors that bind estrogen, they are potential targets for endocrine disruptors. However, to date, direct effects of BPA on GnRH neurons have not been shown. This study investigated the effects of BPA on GnRH neuronal activity using an explant model in which large numbers of primary GnRH neurons are maintained and express many of the receptors found in vivo. Because oscillations in intracellular calcium have been shown to correlate with electrical activity in GnRH neurons, calcium imaging was used to assay the effects of BPA. Exposure to 50μM BPA significantly decreased GnRH calcium activity. Blockage of γ-aminobutyric acid ergic and glutamatergic input did not abrogate the inhibitory BPA effect, suggesting direct regulation of GnRH neurons by BPA. In addition to estrogen receptor-β, single-cell RT-PCR analysis confirmed that GnRH neurons express G protein-coupled receptor 30 (G protein-coupled estrogen receptor 1) and estrogen-related receptor-γ, all potential targets for BPA. Perturbation studies of the signaling pathway revealed that the BPA-mediated inhibition of GnRH neuronal activity occurred independent of estrogen receptors, GPER, or estrogen-related receptor-γ, via a noncanonical pathway. These results provide the first evidence of a direct effect of BPA on GnRH neurons. PMID:26934298

  15. When My Teachers Were Not Anonymous: A Student Proposes that Conflicts with Authority Are Best Addressed by Forging Stronger Bonds with Teachers and Administrators

    ERIC Educational Resources Information Center

    Weissberg, Elizabeth W.

    2004-01-01

    A closer relationship with teachers might impact students in more academic ways. It is said often that teenagers learn the most from their friends. The author believes that a major part of it is due to the relationships these teenagers have with them. In this article, the author proposes that conflicts with authority are best addressed by forging…

  16. 2007 Wholesale Power Rate Adjustment Proceeding (WP-07) : Administrator's Final Record of Decision.

    SciTech Connect

    United States. Bonneville Power Administration.

    2006-07-01

    This Record of Decision (ROD) contains the decisions of the Bonneville Power Administration (BPA), based on the record compiled in this rate proceeding, with respect to the adoption of power rates for the three-year rate period commencing October 1, 2006, through September 30, 2009. This ''2007 Wholesale Power Rate Adjustment Proceeding'' is designed to establish replacement rate schedules and General Rate Schedule Provisions (GRSPs) for those that expire on September 30, 2006. This power rate case also establishes the General Transfer Agreement (GTA) Delivery Charge for the period of October 1, 2007, through September 30, 2009. BPA's Power Subscription Strategy and Record of Decision (Subscription Strategy), as well as other Agency processes, provide much of the policy context for this rate case and are described in Section 2. This ROD follows a full evidentiary hearing and briefing, including an Oral Argument before the BPA Administrator. Sections 3 through 18, including any appendices or attachments, present the issues raised by parties in this proceeding, the parties positions, BPA staff positions on the issues, BPA's evaluations of the positions, and the Administrator's decisions. Parties had the opportunity to file briefs on exceptions to the Draft ROD, before issuance of this Final Record of Decision.

  17. NIOSH testimony to DOL on the Occupational Safety and Health Administration's proposed rule on occupational exposure to cadmium by R. A. Lemen, July 17, 1990

    SciTech Connect

    Not Available

    1990-07-17

    The testimony summarizes the position of NIOSH in support of the proposed rule on cadmium (7440439). NIOSH supports the position of OSHA that exposure to cadmium is associated with increased incidence of lung cancer, emphysema, and kidney dysfunction. Because cadmium is a potential occupational carcinogen, occupational exposures to cadmium should be reduced to the lowest feasible level. NIOSH strongly recommends the use of engineering controls and work practices instead of personal protective equipment, including respiratory protection, for controlling exposures to cadmium. NIOSH responds in this testimony to specific areas covered in the proposed rule including respiratory protection, medical surveillance, medical screening requirements, and exposure monitoring frequency. Use of specific control methods is considered for cadmium plating operations, stabilizer production, and pigment production.

  18. Proposals sought for supplying crude to SPR (Strategic Petroleum Reserve)/ERA (U. S. Economic Regulatory Administration) spells out options for distribution of SPR crude

    SciTech Connect

    Rollins, H.R.

    1980-08-25

    The U.S. Department of Energy (DOE) has asked major oil companies to submit proposals for filling the SPR salt caverns with oil at 100,000 bbl/day and receiving Elk Hills (Calif.) field oil in exchange. Elk Hills is currently producing at 160,000-170,000 bbl/day and will be producing at 190,000 bbl/day in 1982; provision has been made to continue supplying small refiners who currently depend on Elk Hills production. The Government will impose an as-yet undetermined mandatory plan if no satisfactory alternatives are proposed. The 18 salt dome caverns in Louisiana and Texas have a 248 million bbl capacity but have stored only 91.7 million bbl. The capacity will eventually be expanded to 500 million bbl. In accordance with the Energy Security Act, DOE wants to increase storage by about 36 million bbl during the first year of the exchange program, and probably by larger amounts in subsequent years. The submitted proposals, which will be filed with the Defense Fuel Supply Center, will indicate rate of filling (between 5000 and 100,000 bbl/day), type (preferably sweet), and source. According to H. R. Rollins (Econ. Regulatory Admin.), there will be one price for all refiners, based on the average landed cost to all refiners of imported crude in the month of the sale.

  19. Proposal to National Aeronautics and Space Administration for continuation of a grazing incidence imaging telescope for X-ray astronomy using sounding rockets

    NASA Technical Reports Server (NTRS)

    Murray, B.

    1976-01-01

    The construction of a high resolution imaging telescope experiment payload suitable for launch on an Astrobee F sounding rocket was proposed. Also integration, launch, and subsequent data analysis effort were included. The payload utilizes major component subassemblies from the HEAO-B satellite program which were nonflight development units for that program. These were the X ray mirror and high resolution imager brassboard detector. The properties of the mirror and detector were discussed. The availability of these items for a sounding rocket experiment were explored with the HEAO-B project office.

  20. Toxicogenomic analysis of placenta samples from mice exposed to different doses of BPA

    PubMed Central

    Tait, Sabrina; Tassinari, Roberta; Maranghi, Francesca; Mantovani, Alberto

    2015-01-01

    Bisphenol A (BPA), a widespread Endocrine Disrupter mainly used in food contact plastics, may induce adverse effects especially on susceptible lifestages, first of all pregnancy. The present study considered placental development as a potential target of BPA and investigated potential differences in the modes of action of two doses of BPA by a toxicogenomic approach. Pregnant CD-1 mice were administered with vehicle, 0.5 (BPA05) or 50 mg/kg (BPA50) body weight (bw)/die of BPA, from gestational day (GD) 1 to GD11. At GD12 dams were sacrificed and transcriptomic analysis was performed on placenta samples. Histological, histomorphometrical and immunohistochemical analyses were also performed to phenotypically anchor transcriptional changes associated with BPA exposure. The interpretation and description of the overall data are included in a manuscript under revision [1]. Here we describe the experimental design and the analysis performed on the gene expression data which are publicly available through the Gene Expression Omnibus (GEO) database with accession number GSE63852. PMID:26484192

  1. Probabilistic modeling of school meals for potential bisphenol A (BPA) exposure.

    PubMed

    Hartle, Jennifer C; Fox, Mary A; Lawrence, Robert S

    2016-05-01

    Many endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA), are approved for use in food packaging, with unbound BPA migrating into the foods it contacts. Children, with their developing organ systems, are especially susceptible to hormone disruption, prompting this research to model the potential dose of BPA from school-provided meals. Probabilistic exposure models for school meals were informed by mixed methods. Exposure scenarios were based on United States school nutrition guidelines and included meals with varying levels of exposure potential from canned and packaged food. BPA exposure potentials were modeled with a range of 0.00049 μg/kg-BW/day for a middle school student with a low exposure breakfast and plate waste to 1.19 μg/kg-BW/day for an elementary school student eating lunch with high exposure potential. The modeled BPA doses from school meals are below the current US EPA Oral Reference Dose (RfD) of 50 μg/kg-BW/day. Recent research shows BPA animal toxicity thresholds at 2 μg/kg-BW/day. The single meal doses modeled in this research are at the same order of magnitude as the low-dose toxicity thresholds, illustrating the potential for school meals to expose children to chronic toxic levels of BPA. PMID:26395857

  2. Endocrine activity of alternatives to BPA found in thermal paper in Switzerland.

    PubMed

    Goldinger, Daniela M; Demierre, Anne-Laure; Zoller, Otmar; Rupp, Heinz; Reinhard, Hans; Magnin, Roxane; Becker, Thomas W; Bourqui-Pittet, Martine

    2015-04-01

    Alternatives to bisphenol A (BPA) are more and more used in thermal paper receipts. To get an overview of the situation in Switzerland, 124 thermal paper receipts were collected and analyzed. Whereas BPA was detected in most samples (n=100), some alternatives, namely bisphenol S (BPS), Pergafast® 201 and D-8 have been found in 4, 11 and 9 samples respectively. As no or few data on their endocrine activity are available, these chemicals and bisphenol F (BPF) were tested in vitro using the H295R steroidogenesis assay. 17β-Estradiol production was induced by BPA and BPF, whereas free testosterone production was inhibited by BPA and BPS. Both non-bisphenol substances did not show significant effects. The binding affinity to 16 proteins and the toxicological potential (TP) were further calculated in silico using VirtualToxLab™. TP values lay between 0.269 and 0.476 and the main target was the estrogen receptor β (84.4 nM to 1.33 μM). A substitution of BPA by BPF and BPS should be thus considered with caution, since they exhibit almost a similar endocrine activity as BPA. D-8 and Pergafast® 201 could be alternatives to replace BPA, however further analyses are needed to better characterize their effects on the hormonal system. PMID:25579646

  3. Quantitative determination of free and total bisphenol A in human urine using labeled BPA glucuronide and isotope dilution mass spectrometry.

    PubMed

    Kubwabo, Cariton; Kosarac, Ivana; Lalonde, Kaela; Foster, Warren G

    2014-07-01

    Bisphenol A (BPA) is a widely used industrial chemical in the manufacturing of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt normal hormonal function and hence, potentially, have negative effects on the human health. While total BPA is frequently reported, it is recognized that free BPA is the biologically active form and is rarely reported in the literature. The objective of this study was to develop a sensitive and improved method for the measurement of free and total BPA in human urine. Use of a labeled conjugated BPA (bisphenol A-d6 β-D-glucuronide) allowed for the optimization of the enzymatic reaction and permitted an accurate determination of the conjugated BPA concentration in urine samples. In addition, a (13)C12-BPA internal standard was used to account for the analytical recoveries and performance of the isotope dilution method. Solid-phase extraction (SPE) combined with derivatization and analysis using a triple quadrupole GC-EI/MS/MS system achieved very low method detection limit of 0.027 ng/mL. BPA concentrations were measured in urine samples collected during the second and third trimesters of pregnancy in 36 Canadian women. Total maternal BPA concentrations in urine samples ranged from not detected to 9.40 ng/mL (median, 1.21 ng/mL), and free BPA concentrations ranged from not detected to 0.950 ng/mL (median, 0.185 ng/mL). Eighty-six percent of the women had detectable levels of conjugated BPA, whereas only 22 % had detectable levels of free BPA in their urine. BPA levels measured in this study agreed well with data reported internationally. PMID:24817354

  4. 75 FR 70744 - Fiscal Year (FY) 2012-2013 Proposed Power Rate Adjustments Public Hearing and Opportunities for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ...BPA is holding a consolidated rate proceeding, Docket No. BP- 12, to establish power and transmission rates for FY 2012-2013. The purpose of this Federal Register Notice is to provide notice of the proposed power rates and the rates for control area services and certain ancillary services (listed below, Section IV.C.). BPA will issue a separate Federal Register Notice to provide notice of the......

  5. 2007 Wholesale Power Rate Case Final Proposal : Risk Analysis Study.

    SciTech Connect

    United States. Bonneville Power Administration.

    2006-07-01

    BPA's operating environment is filled with numerous uncertainties, and thus the rate-setting process must take into account a wide spectrum of risks. The objective of the Risk Analysis is to identify, model, and analyze the impacts that key risks have on BPA's net revenue (total revenues less total expenses). This is carried out in two distinct steps: a risk analysis step, in which the distributions, or profiles, of operating and non operating risks are defined, and a risk mitigation step, in which different rate tools are tested to assess their ability to recover BPA's costs in the face of this uncertainty. Two statistical models are used in the risk analysis step for this rate proposal, the Risk Analysis Model (RiskMod), and the Non-Operating Risk Model (NORM), while a third model, the ToolKit, is used to test the effectiveness of rate tools options in the risk mitigation step. RiskMod is discussed in Sections 2.1 through 2.4, the NORM is discussed in Section 2.5, and the ToolKit is discussed in Section 3. The models function together so that BPA can develop rates that cover all of its costs and provide a high probability of making its Treasury payments on time and in full during the rate period. By law, BPA's payments to Treasury are the lowest priority for revenue application, meaning that payments to Treasury are the first to be missed if financial reserves are insufficient to pay all bills on time. For this reason, BPA measures its potential for recovering costs in terms of probability of being able to make Treasury payments on time (also known as Treasury Payment Probability or TPP).

  6. Preliminary draft industrial siting administration permit application: Socioeconomic factors technical report. Final technical report, November 1980-May 1982. [Proposed WyCoalGas project in Converse County, Wyoming

    SciTech Connect

    Not Available

    1982-01-01

    Under the with-project scenario, WyCoalGas is projected to make a difference in the long-range future of Converse County. Because of the size of the proposed construction and operations work forces, the projected changes in employment, income, labor force, and population will alter Converse County's economic role in the region. Specifically, as growth occurs, Converse County will begin to satisfy a larger portion of its own higher-ordered demands, those that are currently being satisfied by the economy of Casper. Business-serving and household-serving activities, currently absent, will find the larger income and population base forecast to occur with the WyCoalGas project desirable. Converse County's economy will begin to mature, moving away from strict dependence on extractive industries to a more sophisticated structure that could eventually appeal to national, and certainly, regional markets. The technical demand of the WyCoalGas plant will mean a significant influx of varying occupations and skills. The creation of basic manufacturing, advanced trade and service sectors, and concomitant finance and transportation firms will make Converse County more economically autonomous. The county will also begin to serve market center functions for the smaller counties of eastern Wyoming that currently rely on Casper, Cheyenne or other distant market centers. The projected conditions expected to exist in the absence of the WyCoalGas project, the socioeconomic conditions that would accompany the project, and the differences between the two scenarios are considered. The analysis is keyed to the linkages between Converse County and Natrona County.

  7. Effects of riboflavin photosensitization on the degradation of bisphenol A (BPA) in model and real-food systems.

    PubMed

    Ha, Dong-Oh; Jeong, Min Kyu; Park, Chan Uk; Park, Min Hee; Chang, Pahn-Shick; Lee, Jae Hwan

    2009-06-01

    Effects of riboflavin photosensitizations on the stability of bisphenol A (BPA), a well-known endocrine disrupting chemical, were studied in model and real-food systems by high-performance liquid chromatography (HPLC). Concentration of BPA was significantly decreased under light exposure (P < 0.05) as the concentration of riboflavin increased while those without riboflavin under light or those with riboflavin in the dark did not change significantly (P > 0.05). Addition of 50, 100, and 200 microM sodium azide significantly increased the stability of BPA in riboflavin photosensitization with concentration dependent manner (P < 0.05), implying that a singlet oxygen or type II pathway played a role in the photodegradation of BPA. Stability of BPA in riboflavin was significantly increased in the presence of high concentration of tert-butanol, a hydroxyl radical quencher, under light storage for 80 min, indicating hydroxyl radicals were involved and contributed to the degradation of BPA, at least in part. Availability of riboflavin photosensitization on the photodegradation of BPA was tested in 2 canned tea beverages with different phenolic contents. BPA was more stable in the beverage sample with higher total phenolic contents and free radical scavenging ability. The photodegradation of BPA in riboflavin photosensitization can be an efficient way to decrease the concentration of BPA from environmental or food systems. PMID:19646031

  8. Bisphenol A (BPA) and its source in foods in Japanese markets.

    PubMed

    Sajiki, J; Miyamoto, F; Fukata, H; Mori, C; Yonekubo, J; Hayakawa, K

    2007-01-01

    The determination of bisphenol A (BPA) and/or bisphenol A diglycidyl ether (BADGE) in foods sold in Japanese markets and in water leached from six epoxy resin cans with similar diameters was carried out using high-performance liquid chromatography (HPLC) with electrochemical detection (LC/ECD), LC-mass spectrometric detection (LC/MS) and LC-tandem mass spectrometric detection (LC/MS/MS). BPA concentrations were 0-842 ng g(-1) for 48 canned foods, 0-14 ng g(-1) for 23 foods in plastic containers, and 0-1 ng g(-1) for 16 foods in paper containers. No BADGE was detected in three canned foods. There was no difference in leaching concentrations of BPA into glycine buffers at pHs 8 and 11, and water. The amounts of BPA leached into water from six epoxy resin cans held at 121 degrees C for 20 min were almost the same as the cans' contents and were much higher than the amounts leached from cans held at or below 80 degrees C for 60 min. The amount leached depended on the type of can, but not on the amount of BADGE leached from the cans. Considerably more BPA than BADGE leached to water from six cans. Two cans whose contents had high concentrations of BPA showed no BADGE leaching even at 121 degrees C, suggesting the different kinds of epoxy resin can linings from others. The results imply that the main source of human exposure to BPA is food from cans with linings that contain high percentages of BPA as an additive or an unforeseen contaminant. PMID:17164221

  9. Simultaneous adsorption of Cd²⁺ and BPA on amphoteric surfactant activated montmorillonite.

    PubMed

    Liu, Chongmin; Wu, Pingxiao; Zhu, Yajie; Tran, Lytuong

    2016-02-01

    The study mainly investigated the simultaneous adsorption of bisphenol A (BPA) and Cd(2+) from aqueous solution on octadecane-betaine modified montmorillonite (BS-Mt). The characteristics of the obtained materials were analyzed by X-ray diffraction (XRD), Fourier-transform infrared (FTIR), Specific surface area (BET) and Scanning electron microscopy/Energy disperse spectroscopy (SEM/EDS), confirming that BS-18 was successfully introduced into Mt. Also, factors including initial solution pH, initial Cd(2+)/BPA concentration, contact time and adsorbent dosage on the adsorption processes were shown to be crucial for Cd(2+) adsorption, whereas had negligible effects on BPA adsorption. In this study, we found that pseudo-second-order model fitted well with the adsorption kinetic studies for both Cd(2+) and BPA with an equilibrium time of 24 h. The Cd(2+) and BPA adsorption isotherm could be well described by Freundlich model and Langmuir model, respectively. On the basis of kinetic models, the maximum adsorption capacity of Cd(2+) in aqueous solution was slightly enhanced after modification, indicating that Cd(2+) adsorption on BS-Mt was mainly attributed to direct electrostatic attraction and the chelate reaction, while the dramatic enhancement of maximum adsorption capacity for BPA was due to the hydrophobic interaction. PMID:26451652

  10. Inspection of surveillance activities and administrative leave policy at Bonneville Power Administration, Portland, Oregon

    SciTech Connect

    Not Available

    1994-04-01

    The authors conducted an inspection of surveillance activities and administrative leave policy at the Bonneville Power Administration, Portland, Oregon. The purpose of their inspection was to determine if a covert video surveillance operation conducted at Bonneville Power Administration was consistent with Department of Energy policies and procedures and other applicable regulations and procedures, and to determine if administrative leave policies and procedures used at Bonneville Power Administration in a specific instance were consistent with Department of Energy requirements and the Code of Federal Regulations. This inspection focused on a specific incident that occurred in 1989 on the 5th floor of the BPA Headquarters Building located in Portland, Oregon. The incident involved the soiling of an employee`s personal property with what appeared to be urine.

  11. Bonneville Power Administration 1993 Annual Report.

    SciTech Connect

    United States. Bonneville Power Administration.

    1994-01-01

    For the first time in a decade, Bonneville had to propose a double digit rate increase in 1993. Many of the causes were beyond our control, but self-examination and painful budget cuts put the focus squarely where it should be -- on the changes needed for BPA to compete in an increasingly market-driven business environment. As deregulation and change sweep the electricity industry, BPA has launched a major Competitiveness Project. It`s clear that we can, and will, cut costs and make ourselves more efficient. We can shape our products and services to better reflect what customers want and are willing to pay for. And more than ever we will measure and reward output -- results -- more than process. BPA today is the Northwest`s low-cost supplier of electricity and transmission services. To stay that way, we must adopt a more business-like model. The move does not signal a rejection of our role as a federal agency. In fact, close attention to sound business principles is the only way to strengthen our commitment to fish and wildlife, environment, and other community values.

  12. Developmental programming: Prenatal BPA treatment disrupts timing of LH surge and ovarian follicular wave dynamics in adult sheep

    SciTech Connect

    Veiga-Lopez, A.; Beckett, E.M.; Abi Salloum, B.; Ye, W.; Padmanabhan, V.

    2014-09-01

    Developmental exposure to BPA adversely affects reproductive function. In sheep, prenatal BPA treatment induces reproductive neuroendocrine defects, manifested as LH excess and dampened LH surge and perturbs early ovarian gene expression. In this study we hypothesized that prenatal BPA treatment will also disrupt ovarian follicular dynamics. Pregnant sheep were treated from days 30 to 90 of gestation with 3 different BPA doses (0.05, 0.5, or 5 mg/kg BW/day). All female offspring were estrus synchronized and transrectal ultrasonography was performed daily for 22 days to monitor ovarian follicular and corpora lutea dynamics. Blood samples were collected to assess preovulatory hormonal changes and luteal progesterone dynamics. Statistical analysis revealed that the time interval between the estradiol rise and the preovulatory LH surge was shortened in the BPA-treated females. None of the three BPA doses had an effect on corpora lutea, progestogenic cycles, and mean number or duration of ovulatory and non-ovulatory follicles. However, differences in follicular count trajectories were evident in all three follicular size classes (2–3 mm, 4–5 mm, and ≥ 6 mm) of prenatal BPA-treated animals compared to controls. Number of follicular waves tended also to be more variable in the prenatal BPA-treated groups ranging from 2 to 5 follicular waves per cycle, while this was restricted to 3 to 4 waves in control females. These changes in ovarian follicular dynamics coupled with defects in time interval between estradiol rise and preovulatory LH release are likely to lead to subfertility in prenatal BPA-treated females. - Highlights: • Prenatal BPA shortens interval between estradiol rise and preovulatory LH surge. • Prenatal BPA affects follicular count trajectory and follicular wave occurrence. • Prenatal BPA does not affect ovulatory rate and progesterone dynamics.

  13. Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study.

    PubMed

    Johnson, Sarah A; Javurek, Angela B; Painter, Michele S; Ellersieck, Mark R; Welsh, Thomas H; Camacho, Luísa; Lewis, Sherry M; Vanlandingham, Michelle M; Ferguson, Sherry A; Rosenfeld, Cheryl S

    2016-04-01

    Bisphenol A (BPA) is a ubiquitous industrial chemical used in the production of a wide variety of items. Previous studies suggest BPA exposure may result in neuro-disruptive effects; however, data are inconsistent across animal and human studies. As part of the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), we sought to determine whether female and male rats developmentally exposed to BPA demonstrated later spatial navigational learning and memory deficits. Pregnant NCTR Sprague-Dawley rats were orally dosed from gestational day 6 to parturition, and offspring were directly orally dosed until weaning (postnatal day 21). Treatment groups included a vehicle control, three BPA doses (2.5μg/kg body weight (bw)/day-[2.5], 25μg/kg bw/day-[25], and 2500μg/kg bw/day-[2500]) and a 0.5μg/kg/day ethinyl estradiol (EE)-reference estrogen dose. At adulthood, 1/sex/litter was tested for seven days in the Barnes maze. The 2500 BPA group sniffed more incorrect holes on day 7 than those in the control, 2.5 BPA, and EE groups. The 2500 BPA females were less likely than control females to locate the escape box in the allotted time (p value=0.04). Although 2.5 BPA females exhibited a prolonged latency, the effect did not reach significance (p value=0.06), whereas 2.5 BPA males showed improved latency compared to control males (p value=0.04), although the significance of this result is uncertain. No differences in serum testosterone concentration were detected in any male or female treatment groups. Current findings suggest developmental exposure of rats to BPA may disrupt aspects of spatial navigational learning and memory. PMID:26436835

  14. Effect of BPA on the germination, root development, seedling growth and leaf differentiation under different light conditions in Arabidopsis thaliana.

    PubMed

    Pan, Wen-Juan; Xiong, Can; Wua, Qiu-Ping; Liu, Jin-Xia; Liao, Hong-Mei; Chen, Wei; Liu, Yong-Sheng; Zheng, Lei

    2013-11-01

    Bisphenol A (BPA) is a well-known environmental toxic substance, which exerts unfavorable effects through endocrine disruptor (ER)-dependent and ER-independent mechanisms to threaten ecological systems seriously. BPA may also interact with other environmental factors, such as light and heavy metals, to have a synergetic effect in plants. However, there is little data concerning the toxic effect of BPA on the primary producers-plants and its possible interaction with light-dependent response. Here, the effects of BPA on germination, fresh weight, tap root length, and leaf differentiation were studied in Arabidopsis thaliana under different parts of light spectrum (dark, red, yellow, green, blue, and white light). Our results showed that low-dose BPA (1.0, 5.0 µM) caused an increase in the fresh weight, the tap root length and the lateral root formation of A. thaliana seedlings, while high-dose BPA (10.0, 25.0 µM) show an inhibition effect in a dose-dependent manner. Unlike karrikins, the effects of BPA on germination fresh weight and tap roots length under various light conditions are similar, which imply that BPA has no notable role in priming light response in germination and early seedling growth in A. thaliana. Meanwhile, BPA exposure influences the differentiation of A. thaliana leaf blade significantly in a light-dependent manner with little to no effect in dark and clear effect under red illumination. PMID:24206833

  15. Bisphenol A (BPA) Found in Humans and Water in Three Geographic Regions with Distinctly Different Levels of Economic Development

    PubMed Central

    Karalius, Vytas P.; Harbison, Justin E.; Plange-Rhule, Jacob; van Breemen, Richard B.; Li, Guannan; Huang, Ke; Durazo-Arvizu, Ramon A.; Mora, Nallely; Dugas, Lara R.; Vail, Lane; Tuchman, Nancy C.; Forrester, Terrence; Luke, Amy

    2014-01-01

    The suspected endocrine disruptor bisphenol A (BPA) is associated with the manufacture, distribution, and use of epoxy resins and polycarbonate plastics; thus, studies of this compound have focused primarily on urban areas in developed countries. This small study investigating urinary BPA of 109 people was conducted in the urban United States, urban Jamaica, and rural Ghana. Additionally, local drinking and surface water samples were collected and analyzed from areas near study participants. Levels of BPA in both urine and water were comparable among all three sites. Thus, future studies of BPA should consider expanding investigations to rural areas not typically associated with the compound. PMID:24453495

  16. The Genotoxic and Cytotoxic Effects of Bisphenol-A (BPA) in MCF-7 Cell Line and Amniocytes

    PubMed Central

    Aghajanpour-Mir, Seyed Mohsen; Zabihi, Ebrahim; Akhavan-Niaki, Haleh; Keyhani, Elahe; Bagherizadeh, Iman; Biglari, Sajjad; Behjati, Farkhondeh

    2016-01-01

    Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification. In this study, we investigated the BPA-induced chromosomal damages in MCF-7 cell line, ER-positive and negative amniocyte cells. Cytotoxicity and genotoxicity effects of BPA were also compared between these three cell groups. Expression of estrogen receptors was determined using immunocytochemistry technique. The cell cytotoxicity of BPA was measured by MTT assay. Classic cytogenetic technique was carried out for the investigation of chromosome damage. BPA, in addition to cytotoxicity, had remarkable genotoxicity at concentrations close to the traceable levels in tissues or biological fluids. Although some differences were observed in the amount of damages between ER-positive and negative fetal cells, interestingly, these differences were not significant. The present study showed that BPA could lead to chromosomal aberrations in both ER-dependent and independent pathways at some concentrations or in cell types yet not reported. Also, BPA could probably be considered as a facilitator for some predisposed cells to be cancerous by raising the chromosome instability levels. Finally, estrogen receptor seems to have a different role in cytotoxicity and genotoxicity effects. PMID:27386435

  17. Experimental Studies of Boronophenylalanine ({sup 10}BPA) Biodistribution for the Individual Application of Boron Neutron Capture Therapy (BNCT) for Malignant Melanoma Treatment

    SciTech Connect

    Carpano, Marina; Perona, Marina; Rodriguez, Carla; Nievas, Susana; Olivera, Maria; Santa Cruz, Gustavo A.; Brandizzi, Daniel; Cabrini, Romulo; Pisarev, Mario; Juvenal, Guillermo Juan; Dagrosa, Maria Alejandra

    2015-10-01

    Purpose: Patients with the same histopathologic diagnosis of cutaneous melanoma treated with identical protocols of boron neutron capture therapy (BNCT) have shown different clinical outcomes. The objective of the present studies was to evaluate the biodistribution of boronophenilalanina ({sup 10}BPA) for the potential application of BNCT for the treatment of melanoma on an individual basis. Methods and Materials: The boronophenilalanine (BPA) uptake was evaluated in 3 human melanoma cell lines: MEL-J, A375, and M8. NIH nude mice were implanted with 4 10{sup 6} MEL-J cells, and biodistribution studies of BPA (350 mg/kg intraperitoneally) were performed. Static infrared imaging using a specially modified infrared camera adapted to measure the body infrared radiance of small animals was used. Proliferation marker, Ki-67, and endothelial marker, CD31, were analyzed in tumor samples. Results: The in vitro studies demonstrated different patterns of BPA uptake for each analyzed cell line (P<.001 for MEL-J and A375 vs M8 cells). The in vivo studies showed a maximum average boron concentration of 25.9 ± 2.6 μg/g in tumor, with individual values ranging between 11.7 and 52.0 μg/g of {sup 10}B 2 hours after the injection of BPA. Tumor temperature always decreased as the tumors increased in size, with values ranging between 37°C and 23°C. A significant correlation between tumor temperature and tumor-to-blood boron concentration ratio was found (R{sup 2} = 0.7, rational function fit). The immunohistochemical studies revealed, in tumors with extensive areas of viability, a high number of positive cells for Ki-67, blood vessels of large diameter evidenced by the marker CD31, and a direct logistic correlation between proliferative status and boron concentration difference between tumor and blood (R{sup 2} = 0.81, logistic function fit). Conclusion: We propose that these methods could be suitable for designing new screening protocols applied before melanoma BNCT

  18. 2007 Wholesale Power Rate Case Initial Proposal : Direct Testimony

    SciTech Connect

    United States. Bonneville Power Administration.

    2005-11-01

    The purpose of this testimony is to provide the context and background to the financial and risk policy objectives for BPA's WP-07 Initial Proposal. The testimony contains eight sections. The first is this introduction. Section 2 provides background regarding BPA's Subscription Strategy and the Subscription contracts to which the WP-07 rates will apply. Section 3 describes the financial policy objectives considered when establishing the WP-07 rates. Section 4 describes BPA's risk profile, the risk mitigation tools used in prior rate periods, those proposed here, and additional tools under consideration for the FY 2007-2009 rate period. Section 5 describes financial policy directives and decisions that have shaped the WP-07 Initial Proposal. Section 6 describes the uncertainties of the current litigation regarding the National Marine Fisheries Service (NMFS) Federal Columbia River Power System (FCRPS) Biological Opinion and how it is addressed in this proposal. Section 7 briefly discusses the risk mitigation package in the WP-07 Initial Proposal. Finally, Section 8 describes some liquidity tools that may be incorporated into final studies if circumstances allow.

  19. Conjugated Bisphenol A (BPA) in maternal serum in relation to miscarriage risk

    PubMed Central

    Lathi, Ruth B.; Liebert, Cara A.; Brookfield, Kathleen F.; Taylor, Julia A.; Saal, Frederick S. vom; Fujimoto, Victor Y.; Baker, Valerie L.

    2014-01-01

    Objective To examine the relationship between maternal serum Bisphenol-A (BPA) concentration at the time of the missed period and miscarriage risk. Design Retrospective cohort of prospectively collected serum samples. Setting Academic fertility center. Patients Women presenting for early pregnancy monitoring with singleton pregnancies. Intervention Stored serum samples from 4-5 weeks gestation were analyzed for conjugated serum BPA concentrations. Main Outcomes Live birth, miscarriage, and chromosome content of miscarriage. Results Of the 115 included subjects, there were 47 live births and 68 clinical miscarriages (46 aneuploid and 22 euploid). Median conjugated BPA concentrations were higher in women with miscarriages than those with live births (0.101 vs 0.075 ng/ml). Women with the highest quartile of conjugated BPA had an increased relative risk of miscarriage (1.83, 95% CI 1.14-2.96) compared to women in the lowest quartile. We found a similar increase risk for both euploid and aneuploid miscarriages. Conclusions Maternal conjugated BPA was associated with higher risk of aneuploid and euploid miscarriage in this cohort. The impact of reducing individual exposures on future pregnancy outcomes deserves further study. PMID:24746738

  20. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells.

    PubMed

    Yin, Nuoya; Yao, Xinglei; Qin, Zhanfen; Wang, Yuan-Liang; Faiola, Francesco

    2015-10-01

    The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic stem cell (ESC) properties which can be exerted in toxicity assays. In fact, ESCs can differentiate in culture to mimic embryonic development in vivo, or specifically to virtually any kind of somatic cells. Here, we used the toxicant Bisphenol A (BPA), a chemical known as a hazard to infants and children, and showed that our stem cell toxicology system was able to efficiently recapitulate most of the toxic effects of BPA previously detected by in vitro system or animal tests. More precisely, we demonstrated that BPA affected the proper specification of germ layers during our in vitro mimicking of the embryonic development, as well as the establishment of neural ectoderm and neural progenitor cells. PMID:26456621

  1. Distribution of BPA and metabolic assessment in glioblastoma patients during BNCT treatment: a microdialysis study.

    PubMed

    Bergenheim, A Tommy; Capala, Jacek; Roslin, Michael; Henriksson, Roger

    2005-02-01

    Boron neutron capture therapy (BNCT) is dependent on the selective accumulation of boron-10 in tumour cells. To maximise the radiation effect, the neutrons should be delivered when the ratio between the boron concentration in tumour cells to that in normal tissues reaches maximum. However, the pharmacokinetics of p-boronophenylalanine (BPA) and other boron delivery agents are only partly known. We used microdialysis to investigate the extracellular in vivo kinetics of boron in three intracerebral compartments -- solid tumour, brain adjacent to tumour (BAT), and the normal brain, as well as the subcutaneous tissue before, during, and after BNCT treatment. The findings were compared to the pharmacokinetics of BPA in the blood. We also measured the glucose metabolism and the levels of glutamate and glycerol in those compartments. Four patients were studied, two patients underwent surgical tumour resection and in two a stereotactic biopsy was performed. The patients were given BPA (900 mg/kg body weight) by a 6-h infusion. The infusion was completed approximately 2-3 h before neutron irradiation. In tumour tissue the extracellular concentration of BPA followed that of blood with a maximal concentration of 31.2 ppm and a maximal ratio vs. blood of 1.07. In BAT, the maximal concentration of BPA was 18.0 ppm with the peak level delayed for 4-6 h compared to the peak in blood with a maximal ratio of 1.2. Maximal blood concentration found was 41.0 ppm. The uptake of BPA in the normal brain was considerably lower than that in the blood and tumour tissue. No change in glucose metabolism was observed. The extracellular level of glycerol was increased after treatment in tumour tissue but not in normal brain suggesting a selective acute cytotoxic effect of BNCT on tumour cells. PMID:15735919

  2. BPA Riparian Fencing and Alternative Water Development Projects Completed within Asotin Creek Watershed, 2000 and 2001 Asotin Creek Fencing Final Report of Accomplishments.

    SciTech Connect

    Johnson, B.J.

    2002-01-01

    The Asotin County Conservation District (ACCD) is the primary entity coordinating habitat projects on both private and public lands within the Asotin Creek watershed. The watershed covers approximately 325 square miles in the Blue Mountains of southeastern Washington in Water Resource Inventory Area (WRIA) 35. According to Washington Department of Fish and Wildlife's (WDFW) Priority WRIA's by ''At-Risk Stock Significance Map'', it is the highest priority WRIA in southeastern Washington. Summer steelhead, bull trout, and Snake River spring chinook salmon which are listed under the Endangered Species Act (ESA), are present in the watershed. WDFW manages it as a Wild Steelhead Reserve; no hatchery fish have been released here since 1997. The ACCD has been working with landowners, Bonneville Power Administration (BPA), Washington State Conservation Commission (WCC), Natural Resource Conservation Service (NRCS), Washington Department of Fish and Wildlife (WDFW), U.S. Forest Service, Pomeroy Ranger District (USFS), Nez Perce Tribe, Washington Department of Ecology (DOE), National Marine Fisheries Service (NMFS), and U.S. Fish and Wildlife Service (USFWS) to address habitat projects in Asotin County. Local students, volunteers and Salmon Corps members from the Nez Perce Tribe have been instrumental in the success of the Model Watershed Program on Asotin Creek. ACCD began coordinating habitat projects in 1995 with the help of BPA funding. Approximately two hundred and seventy-six projects have been implemented as of 1999. The Washington State Legislature was successful in securing funding for endangered salmon and steelhead recovery throughout the State in 1998. While these issues were new to most of the State, the ACCD has been securing and administering funding for endangered salmonids since 1994. The ''Asotin Creek Riparian Planting 2000-053-00 and Asotin Creek Riparian Fencing 2000-054-00'' teamed BPA and the Governor's Salmon Recovery Funding to plant approximately 84

  3. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  4. Comparison of the effects of BPA and BPAF on oocyte spindle assembly and polar body release in mice.

    PubMed

    Nakano, Kei; Nishio, Manami; Kobayashi, Norio; Hiradate, Yuuki; Hoshino, Yumi; Sato, Eimei; Tanemura, Kentaro

    2016-04-01

    Bisphenol AF (BPAF), a homolog of bisphenol A (BPA), is a widely used environmental chemical that has adverse effects on reproduction. The aim of this study was to analyse the effects of BPA and BPAF exposure on oocyte maturation in vitro. Oocytes were cultured in the presence of BPA or BPAF (2, 20, 50 or 100 μg/ml) for 18 h. At concentrations of 50 and 100 μg/ml, BPA and BPAF inhibited oocyte maturation, with BPAF treatment causing a sharp decrease in the number of oocytes reaching maturity. Oocytes were exposed to BPA or BPAF at 2 μg/ml and cultured for different durations (6, 9, 12, 15 or 18 h). Both BPAF and BPA caused a cell cycle delay under these conditions. Oocytes cultured in the presence of BPA or BPAF (50 μg/ml) for 21 h were tested for the localization of α-tubulin and MAD2 using immunofluorescence. High concentrations of BPAF induced cell cycle arrest through the activation of the spindle assembly checkpoint. After 12 h of culture in BPAF (50 μg/ml), oocytes were transferred to control medium for 9 h. Only 63.3% oocytes treated in this manner progressed to metaphase II (MII). Oocytes exposed to high doses of BPA experienced a cell cycle delay, but managed to progress to MII when the culture period was prolonged. In addition, MAD2 was localized in the cytoplasm of these oocytes. In conclusion, both BPAF and BPA exposure affected oocyte maturation, however BPAF and BPA have differential effects on SAC activity. PMID:25925194

  5. 2007 Wholesale Power Rate Case Final Proposal : Market Price Forecast Study.

    SciTech Connect

    United States. Bonneville Power Administration.

    2006-07-01

    This study presents BPA's market price forecasts for the Final Proposal, which are based on AURORA modeling. AURORA calculates the variable cost of the marginal resource in a competitively priced energy market. In competitive market pricing, the marginal cost of production is equivalent to the market-clearing price. Market-clearing prices are important factors for informing BPA's power rates. AURORA was used as the primary tool for (a) estimating the forward price for the IOU REP Settlement benefits calculation for fiscal years (FY) 2008 and 2009, (b) estimating the uncertainty surrounding DSI payments and IOU REP Settlements benefits, (c) informing the secondary revenue forecast and (d) providing a price input used for the risk analysis. For information about the calculation of the secondary revenues, uncertainty regarding the IOU REP Settlement benefits and DSI payment uncertainty, and the risk run, see Risk Analysis Study WP-07-FS-BPA-04.

  6. Oversight on Administration's Budget Proposals for Child Nutrition Program. Hearings before the Subcommittee on Elementary, Secondary, and Vocational Education of the Committee on Education and Labor, House of Representatives, Ninety-Eighth Congress, First Session. Hearings held in Washington, D.C., on March 1, 2, 3, 8, 9, 10, 1983.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    The first witness in this hearing was the Assistant Secretary for Food and Consumer Services, Department of Agriculture, who presented the Reagan Administration's 1984 budget proposals for cuts in child nutrition programs. The proposals included changes in the school lunch program, a freeze on the funding level of the WIC program, elimination of…

  7. 78 FR 9771 - Federal Highway Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... Federal Highway Administration Notice of Final Federal Agency Action on Proposed Transportation Project in Illinois and Indiana AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of limitation on..., Federal Highway Administration, 3250 Executive Park Drive, Springfield, Illinois 62703, Phone: (217)...

  8. Demonstration Assessment of Light-Emitting Diode (LED) Retrofit Lamps at the Lobby of the Bonneville Power Administration, Portland, OR

    SciTech Connect

    Miller, Naomi

    2011-07-01

    This report describes the process and results of a demonstration of solid-state lighting (SSL) technology in the lobby of the Bonneville Power Administration (BPA) headquarters building in Portland, Oregon. The project involved a simple retrofit of 32 track lights used to illuminate historical black-and-white photos and printed color posters from the 1930s and 1940s. BPA is a federal power marketing agency in the Northwestern United States, and selected this prominent location to demonstrate energy efficient light-emitting diode (LED) retrofit options that not only can reduce the electric bill for their customers but also provide attractive alternatives to conventional products, in this case accent lighting for BPA's historical artwork.

  9. Classification of PS15bpa as a post maximum Type II supernova

    NASA Astrophysics Data System (ADS)

    Piascik, A. S.; Steele, I. A.

    2015-08-01

    We conducted a spectroscopic observation of transient PS15bpa at 2015-08-06T22:11:16 UT. This transient was identified by the Pan-STARRS Survey for Transients (PSST) in ATel #7876 with a discovery date 2015-08-01.

  10. Low Probability Tail Event Analysis and Mitigation in BPA Control Area: Task 2 Report

    SciTech Connect

    Lu, Shuai; Makarov, Yuri V.; McKinstry, Craig A.; Brothers, Alan J.; Jin, Shuangshuang

    2009-09-18

    Task report detailing low probability tail event analysis and mitigation in BPA control area. Tail event refers to the situation in a power system when unfavorable forecast errors of load and wind are superposed onto fast load and wind ramps, or non-wind generators falling short of scheduled output, causing the imbalance between generation and load to become very significant.

  11. Color Shift Investigations for LED Secondary Optical Designs: Comparison between BPA-PC and PMMA

    NASA Astrophysics Data System (ADS)

    Lu, Guangjun; Yazdan Mehr, M.; van Driel, W. D.; Fan, Xuejun; Fan, Jiajie; Jansen, K. M. B.; Zhang, G. Q.

    2015-07-01

    Recently, color shift of LED-based lighting products has attracted much attention due to its increasing impact on the field application. However, significant research investigations on the color shift mechanisms are not publically available especially for important transmission materials used for secondary optical design. In this paper, broadly used such commercial materials (BPA-PC and PMMA) are experimentally investigated on the color shift effects during aging. Besides this, color shift mechanisms of degradation of transmittance are also studied. Results revealed: (1) Inconsistent degradation of wavelength-dependent transmittance induces the decrease of the blue/yellow light intensity ratio and thus gives rise to the color shift toward the yellow field, which is the color shift mechanism of BPA-PC; (2) Even for the non-aged BPA-PC, the transmittance varies with wavelength in the visible light field due to the chemistry of the material, which caused the change of intensify ratio of blue light to yellow light in the SPD, leading to color change in perception; (3) Oxidation plays a key role in the degradation of transmittance at around the peak wavelength of the blue light field, which is in correlation with the discoloration of thermally-aged BPA-PC materials. By contrast, for the PMMA specimen aged up to 3000 h, oxidation was neither occurred at 85 °C, nor with additional exposure to blue light, nor even with additional humidity of 85%RH.

  12. BPA-Induced Deregulation Of Epigenetic Patterns: Effects On Female Zebrafish Reproduction

    PubMed Central

    Santangeli, Stefania; Maradonna, Francesca; Gioacchini, Giorgia; Cobellis, Gilda; Piccinetti, Chiara Carla; Dalla Valle, Luisa; Carnevali, Oliana

    2016-01-01

    Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related to reproduction are caused by histone modifications, BPA concentrations consistent with environmental exposure were administered to zebrafish for three weeks. Effects on oocyte growth and maturation, autophagy and apoptosis processes, histone modifications, and DNA methylation were assessed by Real-Time PCR (qPCR), histology, and chromatin immunoprecipitation combined with qPCR analysis (ChIP-qPCR). The results showed that 5 μg/L BPA down-regulated oocyte maturation-promoting signals, likely through changes in the chromatin structure mediated by histone modifications, and promoted apoptosis in mature follicles. These data indicate that the negative effects of BPA on the female reproductive system may be due to its upstream ability to deregulate epigenetic mechanism. PMID:26911650

  13. BPA-Induced Deregulation Of Epigenetic Patterns: Effects On Female Zebrafish Reproduction.

    PubMed

    Santangeli, Stefania; Maradonna, Francesca; Gioacchini, Giorgia; Cobellis, Gilda; Piccinetti, Chiara Carla; Dalla Valle, Luisa; Carnevali, Oliana

    2016-01-01

    Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related to reproduction are caused by histone modifications, BPA concentrations consistent with environmental exposure were administered to zebrafish for three weeks. Effects on oocyte growth and maturation, autophagy and apoptosis processes, histone modifications, and DNA methylation were assessed by Real-Time PCR (qPCR), histology, and chromatin immunoprecipitation combined with qPCR analysis (ChIP-qPCR). The results showed that 5 μg/L BPA down-regulated oocyte maturation-promoting signals, likely through changes in the chromatin structure mediated by histone modifications, and promoted apoptosis in mature follicles. These data indicate that the negative effects of BPA on the female reproductive system may be due to its upstream ability to deregulate epigenetic mechanism. PMID:26911650

  14. "Stockpile" of Slight Transcriptomic Changes Determines the Indirect Genotoxicity of Low-Dose BPA in Thyroid Cells.

    PubMed

    Porreca, Immacolata; Ulloa Severino, Luisa; D'Angelo, Fulvio; Cuomo, Danila; Ceccarelli, Michele; Altucci, Lucia; Amendola, Elena; Nebbioso, Angela; Mallardo, Massimo; De Felice, Mario; Ambrosino, Concetta

    2016-01-01

    Epidemiological and experimental data highlighted the thyroid-disrupting activity of bisphenol A (BPA). Although pivotal to identify the mechanisms of toxicity, direct low-dose BPA effects on thyrocytes have not been assessed. Here, we report the results of microarray experiments revealing that the transcriptome reacts dynamically to low-dose BPA exposure, adapting the changes in gene expression to the exposure duration. The response involves many genes, enriching specific pathways and biological functions mainly cell death/proliferation or DNA repair. Their expression is only slightly altered but, since they enrich specific pathways, this results in major effects as shown here for transcripts involved in the DNA repair pathway. Indeed, even though no phenotypic changes are induced by the treatment, we show that the exposure to BPA impairs the cell response to further stressors. We experimentally verify that prolonged exposure to low doses of BPA results in a delayed response to UV-C-induced DNA damage, due to impairment of p21-Tp53 axis, with the BPA-treated cells more prone to cell death and DNA damage accumulation. The present findings shed light on a possible mechanism by which BPA, not able to directly cause genetic damage at environmental dose, may exert an indirect genotoxic activity. PMID:26982218

  15. “Stockpile” of Slight Transcriptomic Changes Determines the Indirect Genotoxicity of Low-Dose BPA in Thyroid Cells

    PubMed Central

    Porreca, Immacolata; Ulloa Severino, Luisa; D’Angelo, Fulvio; Cuomo, Danila; Ceccarelli, Michele; Altucci, Lucia; Amendola, Elena; Nebbioso, Angela; Mallardo, Massimo

    2016-01-01

    Epidemiological and experimental data highlighted the thyroid-disrupting activity of bisphenol A (BPA). Although pivotal to identify the mechanisms of toxicity, direct low-dose BPA effects on thyrocytes have not been assessed. Here, we report the results of microarray experiments revealing that the transcriptome reacts dynamically to low-dose BPA exposure, adapting the changes in gene expression to the exposure duration. The response involves many genes, enriching specific pathways and biological functions mainly cell death/proliferation or DNA repair. Their expression is only slightly altered but, since they enrich specific pathways, this results in major effects as shown here for transcripts involved in the DNA repair pathway. Indeed, even though no phenotypic changes are induced by the treatment, we show that the exposure to BPA impairs the cell response to further stressors. We experimentally verify that prolonged exposure to low doses of BPA results in a delayed response to UV-C-induced DNA damage, due to impairment of p21-Tp53 axis, with the BPA-treated cells more prone to cell death and DNA damage accumulation. The present findings shed light on a possible mechanism by which BPA, not able to directly cause genetic damage at environmental dose, may exert an indirect genotoxic activity. PMID:26982218

  16. Exposure assessment of adult intake of bisphenol A (BPA) with emphasis on canned food dietary exposures

    PubMed Central

    Lorber, Matthew; Schecter, Arnold; Paepke, Olaf; Shropshire, William; Christensen, Krista; Birnbaum, Linda

    2015-01-01

    Bisphenol A (BPA) is a high-volume, synthetic compound found in epoxy resins and plastics used in food packaging. Food is believed to be a major source of BPA intake. In this study, we measured the concentration of BPA in convenience samplings of foodstuffs purchased in Dallas, Texas. Sampling entailed collection of 204 samples of fresh, frozen, and canned foods in two rounds in 2010. BPA was positive in 73% of the canned food samples, while it was found in only 7% of non-canned foods at low concentrations. The results of this food sampling program were used to calculate adult dietary intakes of BPA. A pathway approach combined food intakes, a “canned fraction” parameter which described what portion of total intake of that food came from canned products, and measured food concentrations. Dietary intakes were calculated as 12.6 ng/kg-day, of which 12.4 ng/kg-day was from canned foods. Canned vegetable intakes alone were 11.9 ng/kg-day. This dietary intake was compared to total intakes of BPA estimated from urine measurements of the National Health and Nutrition Examination Survey (NHANES). Total adult central tendency intakes ranged from 30 to 70 ng/kg-day for NHANES cycles between 2005 and 2010. Three possibilities were explored to explain the difference between these two approaches for intake estimation. Not all foods which may have been canned, particularly canned beverages such as soft drinks, were sampled in our food sampling program. Second, non-food pathways of exposure may be important for adults, including thermal paper exposures, and dust and air exposures. Finally, our canned food concentrations may not be adequately representative of canned foods in the United States; they were found to be generally lower compared to canned food concentrations measured in six other worldwide food surveys including three in North America. Our finding that canned food concentrations greatly exceeded non-canned concentrations was consistent with other studies, and

  17. Exposure assessment of adult intake of bisphenol A (BPA) with emphasis on canned food dietary exposures.

    PubMed

    Lorber, Matthew; Schecter, Arnold; Paepke, Olaf; Shropshire, William; Christensen, Krista; Birnbaum, Linda

    2015-04-01

    Bisphenol A (BPA) is a high-volume, synthetic compound found in epoxy resins and plastics used in food packaging. Food is believed to be a major source of BPA intake. In this study, we measured the concentration of BPA in convenience samplings of foodstuffs purchased in Dallas, Texas. Sampling entailed collection of 204 samples of fresh, frozen, and canned foods in two rounds in 2010. BPA was positive in 73% of the canned food samples, while it was found in only 7% of non-canned foods at low concentrations. The results of this food sampling program were used to calculate adult dietary intakes of BPA. A pathway approach combined food intakes, a "canned fraction" parameter which described what portion of total intake of that food came from canned products, and measured food concentrations. Dietary intakes were calculated as 12.6 ng/kg-day, of which 12.4 ng/kg-day was from canned foods. Canned vegetable intakes alone were 11.9 ng/kg-day. This dietary intake was compared to total intakes of BPA estimated from urine measurements of the National Health and Nutrition Examination Survey (NHANES). Total adult central tendency intakes ranged from 30 to 70 ng/kg-day for NHANES cycles between 2005 and 2010. Three possibilities were explored to explain the difference between these two approaches for intake estimation. Not all foods which may have been canned, particularly canned beverages such as soft drinks, were sampled in our food sampling program. Second, non-food pathways of exposure may be important for adults, including thermal paper exposures, and dust and air exposures. Finally, our canned food concentrations may not be adequately representative of canned foods in the United States; they were found to be generally lower compared to canned food concentrations measured in six other worldwide food surveys including three in North America. Our finding that canned food concentrations greatly exceeded non-canned concentrations was consistent with other studies, and

  18. Modernizing Administration.

    ERIC Educational Resources Information Center

    Lombardi, Vincent L.; Hildebrand, Verna

    1981-01-01

    Suggests assignment of research duties and rotation of teaching and management roles for college administrators, to increase their effectiveness and diminish the negative effects of declining enrollments. (JD)

  19. Environmental audit, Bonneville Power Administration, lower Columbia area

    SciTech Connect

    Not Available

    1990-11-01

    This report documents the results of the US Department of Energy's (DOE's) Environmental Audit conducted by the DOE Headquarters Office of Environmental Audit within the Bonneville Power Administration's (BPA's) Lower Columbia Area. The BPA facilities included in the Audit are the Ross Complex in Vancouver, Washington; the substations of North Bonneville, North Bonneville Annex, Camas, and Longview within the state of Washington; and the Acton and Troutdale Substations within the state of Oregon. The independent Audit was conducted by a team of professionals from DOE and contractors. The purpose of the Audit is to provide the Secretary of Energy, Admiral James D. Watkins, Ret., with the status of environmental programs within BPA's Lower Columbia Area. The Environmental Audit team identified 25 findings dealing with the lack of conformance with federal and state laws and regulations and DOE Orders, and 7 findings in which BMPs were not attained. Although all findings require corrective action, none required cessation of operations or reflect situations that present an immediate risk to public health or the environment. The Audit team noted inadequacies in PCB management included storage, labeling, reporting, and spill control. The most significant causal factors for the findings include lack of policy implementation throughout the Lower Columbia Area, inadequate training of personnel charged with environmental protection, lack of standard operating procedures for many programs, lack of reviews and appraisals, and an inaccurate perception of low risk for environmental concerns.

  20. Developmental programming: Prenatal BPA treatment disrupts timing of LH surge and ovarian follicular wave dynamics in adult sheep

    PubMed Central

    Veiga-Lopez, A; Beckett, EM; Abi Salloum, B; Ye, W; Padmanabhan, V

    2014-01-01

    Developmental exposure to BPA adversely affects reproductive function. In sheep, prenatal BPA treatment induces reproductive neuroendocrine defects, manifested as LH excess and dampened LH surge and perturbs early ovarian gene expression. In this study we hypothesized that prenatal BPA treatment will also disrupt ovarian follicular dynamics. Pregnant sheep were treated from days 30 to 90 of gestation with 3 different BPA doses (0.05, 0.5, or 5 mg/kg BW/day). All female offspring were estrus synchronized and transrectal ultrasonography was performed daily for 22 days to monitor ovarian follicular and corpora lutea dynamics. Blood samples were collected to assess hormonal preovulatory changes and luteal progesterone dynamics. Statistical analysis revealed that the time interval between the estradiol rise and the preovulatory LH surge was shortened in the BPA-treated females. None of the three BPA doses had an effect on corpora lutea, progestogenic cycles, and mean or duration of ovulatory and non-ovulatory follicles. However, differences in follicular count trajectories were evident in all three follicular size classes (2–3 mm, 4–5 mm, and ≥ 6 mm) of prenatal BPA-treated animals compared to controls. Number of follicular waves tended also to be more variable in the prenatal BPA-treated groups ranging from 2 to 5 follicular waves per cycle, while this was restricted to 3 to 4 waves in control females. These changes in ovarian follicular dynamics coupled with defects in time interval between estradiol rise and preovulatory LH release are likely to lead to subfertility in prenatal BPA-treated females. PMID:24923655

  1. Migration of bisphenol A (BPA) from can coatings into a fatty-food simulant and tuna fish.

    PubMed

    Munguía-López, E M; Gerardo-Lugo, S; Peralta, E; Bolumen, S; Soto-Valdez, H

    2005-09-01

    The effect of heat processing, storage time and temperature on the migration of bisphenol A (BPA) from organosol and epoxy can coatings to a fatty-food simulant and tuna was determined. Analyses of BPA were performed by RP-HPLC with fluorescence detection. Four migration experiments, performed between 2000 and 2003, using cans with organosol, epoxy and a combination of both types of coatings were performed under different processing conditions and storage times. Migration levels as high as 646.5 microg kg(-1) BPA from an organosol coating of tuna fish cans were found using a fatty-food simulant following the heat processing of the simulant-filled cans. Levels ranging from 11.3 to 138.4 microg kg(-1) BPA from tuna cans coated with an epoxy resin migrated to the fatty-food simulant during 1 year at 25 degrees C. Levels of BPA migration into a fatty-food simulant from thermally processed and stored tuna cans coated with a combination of organosol and epoxy resins and from vegetable cans coated with an epoxy resin were below the limit of quantitation of 10.0 microg kg(-1). Migration of BPA to tuna ranged from <7.1 to 105.4 microg kg(-1) during long-term storage at 25 degrees C. BPA levels in tuna cans purchased from three local supermarkets ranged from <7.1 to 102.7 microg kg(-1). The highest migration levels were found following heat processing at temperatures as high as 121 degrees C and at times as long as 90 min. Coatings from different can batches can give different levels of BPA migration. The migration levels of BPA found in this work are below the present European Union migration limit, except the 646.5 microg kg(-1) found after the commercial heating process was applied to the simulant-filled cans coated with the organosol resin. PMID:16192075

  2. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.

    PubMed

    Panchanathan, Ravichandran; Liu, Hongzhu; Leung, Yuet-Kin; Ho, Shuk-mei; Choubey, Divaker

    2015-11-01

    Environmental factors contribute to the development of autoimmune diseases, including systemic lupus erythematosus (SLE), which exhibits a strong female bias (female-to-male ratio 9:1). However, the molecular mechanisms remain largely unknown. Because a feedforward loop between the female sex hormone estrogen (E2) and type I interferon (IFN-α/β)-signaling induces the expression of certain p200-family proteins (such as murine p202 and human IFI16) that regulate innate immune responses and modify lupus susceptibility, we investigated whether treatment of myeloid cells with bisphenol A (BPA), an environmental estrogen, could regulate the p200-family proteins and activate innate immune responses. We found that treatment of murine bone marrow-derived cells (BMCs) and human peripheral blood mononuclear cells with BPA induced the expression of ERα and IFN-β, activated the IFN-signaling, and stimulated the expression of the p202 and IFI16 proteins. Further, the treatment increased levels of the NLRP3 inflammasome and stimulated its activity. Accordingly, BPA-treatment of BMCs from non lupus-prone C57BL/6 and the lupus-prone (NZB×NZW)F1 mice activated the type I IFN-signaling, induced the expression of p202, and activated an inflammasome activity. Our study demonstrates that BPA-induced signaling in the murine and human myeloid cells stimulates the type I IFN-signaling that results in an induction of the p202 and IFI16 innate immune sensors for the cytosolic DNA and activates an inflammasome activity. These observations provide novel molecular insights into the role of environmental BPA exposures in potentiating the development of certain autoimmune diseases such as SLE. PMID:26277401

  3. 77 FR 43067 - Proposed Agency Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    .... Energy Information Administration Proposed Agency Information Collection AGENCY: U.S. Energy Information Administration (EIA), Department of Energy (DOE). ACTION: Agency Information Collection Activities: Proposed Information Collection; Notice and Request for Comments. SUMMARY: The EIA is soliciting comments on...

  4. Administrative Support.

    ERIC Educational Resources Information Center

    Doran, Dorothy; And Others

    This guide is intended to assist business education teachers in administrative support courses. The materials presented are based on the Arizona validated occupational competencies and tasks for the occupations of receptionist, secretary, and administrative assistant. Word processing skills have been infused into each of the three sections. The…

  5. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  6. Survey of Magnetic Fields Near BPA 230-kV and 500-kV Transmission Lines.

    SciTech Connect

    Perrin, Nancy; Aggarwal, Rajinder Pal; Bracken, T. Daniel

    1991-05-20

    The purpose of this study was to characterize typical levels and variability of 60Hz magnetic fields at the centerline and edge of right-of-way of Bonneville Power Administration (BPA) 230-kV and 500-kV transmission lines. This was accomplished by taking magnetic field measurements at over 800 spans in Oregon and Washington. The spans were sampled using a stratified random sampling procedure with region (East vs. West), voltage (230-kV vs 500-kV), and circuit configuration as strata. There were five different circuit configuration groups for each region/voltage category requiring a total of 200 strata. Magnetic field measurements were taken at 13 locations under each span using an EMDEX-C as a survey meter. Additional information recorded for each span included conductor height (at 10 locations), right-of-way width, longitudinal and lateral slope, time of day, vegetation, terrain, weather conditions, temperature, wind speed, span length and presence of other lines in the corridor. 9 refs., 17 figs., 26 tabs.

  7. Electronic and chemical structure of an organic light emitter embedded in an inorganic wide-bandgap semiconductor: Photoelectron spectroscopy of layered and composite structures of Ir(BPA) and ZnSe

    NASA Astrophysics Data System (ADS)

    Dimamay, Mariel; Mayer, Thomas; Hadziioannou, Georges; Jaegermann, Wolfram

    2015-05-01

    Luminescent organic phases embedded in conductive inorganic matrices are proposed for hybrid organic-inorganic light-emitting diodes. In this configuration, the organic dye acts as the radiative recombination site for charge carriers injected into the inorganic matrix. Our investigation is aimed at finding a material combination where the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) of the organic dye are situated in between the valence and conduction bands of the inorganic matrix in order to promote electron and hole transfer from the matrix to the dye. Bilayer and composite thin films of zinc selenide (ZnSe) and a red iridium complex (Ir(BPA)) organic light emitter were prepared in situ via UHV thermal evaporation technique. The electronic and atomic structures were studied applying X-ray and ultraviolet photoelectron spectroscopies. The measured energy band alignments for the ZnSe/Ir(BPA) bilayer and ZnSe+Ir(BPA) composite reveal that the HOMO and LUMO of the organic dye are positioned in the ZnSe bandgap. For the initial steps of ZnSe deposition on a dye film to form Ir(BPA)/ZnSe bilayers, zinc atoms intercalate into the dye film leaving behind an excess of selenium at the interface that partly reacts with dye molecules. Photoelectron spectroscopy of the composites shows the same species suggesting a similar mechanism. This mechanism leads to composite films with increased content of amorphous phases in the inorganic matrix, thereby affecting its conductivity, as well as to the presence of nonradiative recombination sites provided by the intercalated Zn atoms.

  8. Electronic and chemical structure of an organic light emitter embedded in an inorganic wide-bandgap semiconductor: Photoelectron spectroscopy of layered and composite structures of Ir(BPA) and ZnSe

    SciTech Connect

    Dimamay, Mariel; Mayer, Thomas; Jaegermann, Wolfram; Hadziioannou, Georges

    2015-05-07

    Luminescent organic phases embedded in conductive inorganic matrices are proposed for hybrid organic-inorganic light-emitting diodes. In this configuration, the organic dye acts as the radiative recombination site for charge carriers injected into the inorganic matrix. Our investigation is aimed at finding a material combination where the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) of the organic dye are situated in between the valence and conduction bands of the inorganic matrix in order to promote electron and hole transfer from the matrix to the dye. Bilayer and composite thin films of zinc selenide (ZnSe) and a red iridium complex (Ir(BPA)) organic light emitter were prepared in situ via UHV thermal evaporation technique. The electronic and atomic structures were studied applying X-ray and ultraviolet photoelectron spectroscopies. The measured energy band alignments for the ZnSe/Ir(BPA) bilayer and ZnSe+Ir(BPA) composite reveal that the HOMO and LUMO of the organic dye are positioned in the ZnSe bandgap. For the initial steps of ZnSe deposition on a dye film to form Ir(BPA)/ZnSe bilayers, zinc atoms intercalate into the dye film leaving behind an excess of selenium at the interface that partly reacts with dye molecules. Photoelectron spectroscopy of the composites shows the same species suggesting a similar mechanism. This mechanism leads to composite films with increased content of amorphous phases in the inorganic matrix, thereby affecting its conductivity, as well as to the presence of nonradiative recombination sites provided by the intercalated Zn atoms.

  9. Proposed fish passage improvements at Three Mile Falls Diversion Dam, Umatilla River, Oregon: Finding of no significant impact

    SciTech Connect

    Not Available

    1986-05-01

    The Bureau of Reclamation proposes to administer the construction of fish passage and protective facilities at Three Mile Falls Diversion Dam on the Umatilla River in Oregon to increase the numbers of anadromous fish. The Bonneville Power Administration (BPA) proposes to provide funding for the project. These agencies' actions would implement section 904(d) of the Northwest Power Planning Council's Columbia River Basin Fish and Wildlife Program which addresses the provision of offsite enhancement to compensate for fish and wildlife losses caused by hydroelectric project development and operations throughout the Columbia River Basin. This Finding of No Significant Impact (FONSI) is the National Environmental Policy Act (NEPA) decision document for both agencies. The proposed action would improve both upstream and downstream passage by providing a new right bank ladder on Three Mile Falls Diversion Dam, modifying the existing left bank ladder, and installing rotary drum fish screens and related structures on the adjacent West Extension Irrigation District (WEID) Canal. Four other alternatives are considered in the environmental assessment (EA): a concrete apron plus a left bank ladder; a cap on the crest of the dam plus a left bank ladder; dam removal; and no action. 5 figs., 6 tabs.

  10. Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA).

    PubMed

    Hormann, Annette M; Vom Saal, Frederick S; Nagel, Susan C; Stahlhut, Richard W; Moyer, Carol L; Ellersieck, Mark R; Welshons, Wade V; Toutain, Pierre-Louis; Taylor, Julia A

    2014-01-01

    Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone's urine, suggesting widespread exposure from multiple sources. Regulatory agencies estimate that virtually all BPA exposure is from food and beverage packaging. However, free BPA is applied to the outer layer of thermal receipt paper present in very high (∼20 mg BPA/g paper) quantities as a print developer. Not taken into account when considering thermal paper as a source of BPA exposure is that some commonly used hand sanitizers, as well as other skin care products, contain mixtures of dermal penetration enhancing chemicals that can increase by up to 100 fold the dermal absorption of lipophilic compounds such as BPA. We found that when men and women held thermal receipt paper immediately after using a hand sanitizer with penetration enhancing chemicals, significant free BPA was transferred to their hands and then to French fries that were eaten, and the combination of dermal and oral BPA absorption led to a rapid and dramatic average maximum increase (Cmax) in unconjugated (bioactive) BPA of ∼7 ng/mL in serum and ∼20 µg total BPA/g creatinine in urine within 90 min. The default method used by regulatory agencies to test for hazards posed by chemicals is intra-gastric gavage. For BPA this approach results in less than 1% of the administered dose being bioavailable in blood. It also ignores dermal absorption as well as sublingual absorption in the mouth that both bypass first-pass liver metabolism. The elevated levels of BPA that we observed due to holding thermal paper after using a product containing dermal penetration enhancing chemicals have been related to an increased risk for a wide range of developmental abnormalities as well as diseases in adults. PMID:25337790

  11. Holding Thermal Receipt Paper and Eating Food after Using Hand Sanitizer Results in High Serum Bioactive and Urine Total Levels of Bisphenol A (BPA)

    PubMed Central

    Hormann, Annette M.; vom Saal, Frederick S.; Nagel, Susan C.; Stahlhut, Richard W.; Moyer, Carol L.; Ellersieck, Mark R.; Welshons, Wade V.; Toutain, Pierre-Louis; Taylor, Julia A.

    2014-01-01

    Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone’s urine, suggesting widespread exposure from multiple sources. Regulatory agencies estimate that virtually all BPA exposure is from food and beverage packaging. However, free BPA is applied to the outer layer of thermal receipt paper present in very high (∼20 mg BPA/g paper) quantities as a print developer. Not taken into account when considering thermal paper as a source of BPA exposure is that some commonly used hand sanitizers, as well as other skin care products, contain mixtures of dermal penetration enhancing chemicals that can increase by up to 100 fold the dermal absorption of lipophilic compounds such as BPA. We found that when men and women held thermal receipt paper immediately after using a hand sanitizer with penetration enhancing chemicals, significant free BPA was transferred to their hands and then to French fries that were eaten, and the combination of dermal and oral BPA absorption led to a rapid and dramatic average maximum increase (Cmax) in unconjugated (bioactive) BPA of ∼7 ng/mL in serum and ∼20 µg total BPA/g creatinine in urine within 90 min. The default method used by regulatory agencies to test for hazards posed by chemicals is intra-gastric gavage. For BPA this approach results in less than 1% of the administered dose being bioavailable in blood. It also ignores dermal absorption as well as sublingual absorption in the mouth that both bypass first-pass liver metabolism. The elevated levels of BPA that we observed due to holding thermal paper after using a product containing dermal penetration enhancing chemicals have been related to an increased risk for a wide range of developmental abnormalities as well as diseases in adults. PMID:25337790

  12. BPA and phthalate fate in a sewage network and an elementary river of France. Influence of hydroclimatic conditions.

    PubMed

    Tran, Bich Chau; Teil, Marie Jeanne; Blanchard, Martine; Alliot, Fabrice; Chevreuil, Marc

    2015-01-01

    Our purpose was to characterize the fate of bisphenol A (BPA) and phthalate contamination simultaneously in a sewage network and a watercourse, in relation with hydrological and climatic conditions. An elementary catchment of the Seine basin, receiving effluents from a wastewater treatment plant (WWTP), was chosen because of its basic hydrological features. BPA and DEHP concentrations in the WWTP inputs were 4 and 33 μg L(-1) whereas in the outputs, they were only 0.4 and 2 μg L(-1), respectively. Contaminant ratios in the suspended sediment phase of the WWTP inputs ranged from 0.5% to 88%, related to their molecular properties. BPA and phthalates were effectively removed in the WWTP (>90% for both compounds), by degradation and decantation. Upstream of the discharge, river concentrations ranged from 0.002 to 0.175 μg L(-1) for BPA and from 0.16 to 0.90 μg L(-1) for DEHP. Downstream from the WWTP outputs, concentrations ranged from 0.11 to 0.79 μg L(-1) for BPA and from 0.31 μg L(-1) to 1.7 μg L(-1) for DEHP: the WWTP discharge led to contaminant increases of 3.8 and 2 times, respectively. Far downstream, concentrations were lower ranging from 0.11 to 0.19 μg L(-1) for BPA and from 0.36 μg L(-1) to 1.1 μg L(-1) for DEHP. BPA and phthalates displayed opposite seasonal variations with a decrease for the first one and an increase for the second one during summer. BPA contamination in the Charmoise river derived mainly from the WWTP, while phthalate contamination was attributed to both WWTP discharges and diffuse sources such as atmospheric bulk deposition. PMID:24964009

  13. The Autotransporter BpaB Contributes to the Virulence of Burkholderia mallei in an Aerosol Model of Infection

    PubMed Central

    Zimmerman, Shawn M.; Michel, Frank

    2015-01-01

    Burkholderia mallei is a highly pathogenic bacterium that causes the zoonosis glanders. Previous studies indicated that the genome of the organism contains eight genes specifying autotransporter proteins, which are important virulence factors of Gram-negative bacteria. In the present study, we report the characterization of one of these autotransporters, BpaB. Database searches identified the bpaB gene in ten B. mallei isolates and the predicted proteins were 99-100% identical. Comparative sequence analyses indicate that the gene product is a trimeric autotransporter of 1,090 amino acids with a predicted molecular weight of 105-kDa. Consistent with this finding, we discovered that recombinant bacteria expressing bpaB produce a protein of ≥300-kDa on their surface that is reactive with a BpaB-specific monoclonal antibody. Analysis of sera from mice infected with B. mallei indicated that animals produce antibodies against BpaB during the course of disease, thus establishing production of the autotransporter in vivo. To gain insight on its role in virulence, we inactivated the bpaB gene of B. mallei strain ATCC 23344 and determined the median lethal dose of the mutant in a mouse model of aerosol infection. These experiments revealed that the bpaB mutation attenuates virulence 8-14 fold. Using a crystal violet-based assay, we also discovered that constitutive production of BpaB on the surface of B. mallei promotes biofilm formation. To our knowledge, this is the first report of a biofilm factor for this organism. PMID:25993100

  14. A Discriminant Analysis of Majors in the College Business and Public Administration at the University of North Dakota. North Dakota Economics Studies, Number 52.

    ERIC Educational Resources Information Center

    Tedefalk, Rolf K.

    Researchers have demonstrated that particular careers attract individuals with distinct identifiable personality profiles and learning styles, and this idea is extended to the selection of majors within the College of Business and Public Administration (BPA) at the University of North Dakota. The Myers-Briggs Type Indicator (MBTI) was used both to…

  15. Electroenzymatic oxidation of bisphenol A (BPA) based on the hemoglobin (Hb) film in a membraneless electrochemical reactor.

    PubMed

    Tang, Tiantian; Hou, Juying; Ai, Shiyun; Qiu, Yanyan; Ma, Qiang; Han, Ruixia

    2010-09-15

    This paper presents a novel electroenzymatic method for the treatment of bisphenol A (BPA) in a membraneless electrochemical reactor. The electrochemical reactor was arranged with a stainless steel and an enzymatic film as anode and cathode, respectively. The enzymatic film was formed by immobilizing hemoglobin (Hb) on carbon fiber. In the membraneless electrochemical reactor, hydrogen peroxide (H(2)O(2)) was generated in situ in cathode and BPA was oxidated and removed by the combining Hb with H(2)O(2). The experimental conditions for electrogeneration of H(2)O(2) and electroremoval of BPA were optimized. Experimental results showed that in supplied voltage 2.4 V, pH 5.0 and oxygen flow rate 25 mL/min, the electrogeneration of H(2)O(2) and the electroenzymatic removal of BPA were highest. Under optimal operation conditions, the removal efficiency of BPA reached 50.7% in 120 min and then kept constant when further prolonging the period of reaction. Compared with electrochemical and biochemical methods, the removal of BPA through electroenzymatic method was comparatively favorable. PMID:20605681

  16. Central Administration. Interim Report.

    ERIC Educational Resources Information Center

    Duke Univ., Durham, NC.

    Because the configuration of the central administration of Duke University has recently been modified, this report was prepared: (1) to describe the changes and rearrangements thus far introduced; (2) to propose desirable clarifications not yet provided; (3) to recommend certain additional changes where these may already appear to be needed; and…

  17. 78 FR 14841 - Notice of Proposed Information Collection Requests

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    .... The Director, Office of Administration, publishes that notice containing proposed information.... SUMMARY: The Director, Office of Administration, invites comments on the proposed information collection..., Director, Office of Administration, National Mediation Board. Application for Investigation...

  18. Proposal Writing.

    ERIC Educational Resources Information Center

    Grant, Andrew; And Others

    1988-01-01

    The basics of effective proposal writing, from content to structure to length, are presented in three articles: "Knowledge Is Power" (Andrew Grant, Emily S. Berkowitz), "Write on the Money" (Lucy Knight); and "The Problem Proposal." (MLW)

  19. Impact of the Administration's Proposed Budget Cuts on Children. Joint Hearing before the Subcommittee on Oversight, Committee on Ways and Means and the Subcommittee on Health and the Environment, Committee on Energy and Commerce. House of Representatives, 97th Congress, 2nd Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Ways and Means.

    Joint hearings of two subcommittees of the House of Representatives, reflecting a continuation of previous field hearings, were held to receive additional testimony concerning the impact of the administration's proposed budget cuts on a broad range of health, nutrition, welfare, and educational programs serving children and their families. Five…

  20. 75 FR 15430 - Chief Joseph Hatchery Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Bonneville Power Administration Chief Joseph Hatchery Program AGENCY: Bonneville Power Administration (BPA... announces the availability of the ROD to implement the proposed action identified in BPA's Chief Joseph Hatchery Program Environmental Impact Statement (DOE/EIS-0384, November 2009). BPA has decided to fund...

  1. Might iodomethyl-{alpha}-tyrosine be a surrogate for BPA in BNCT?

    SciTech Connect

    Miura, Michiko; Micca, P.L.; Nawrocky, M.M.; Slatkin, D.N.

    1996-12-31

    A single-photon emission computed tomography [SPECT] imaging agent that is an analogue of a boron carrier for boron neutron-capture therapy [BNCT] of cerebral gliomas would be useful for assessing the kinetics of boron uptake in tumors and in the surrounding brain tissues noninvasively. BNCT is based on the interaction of thermalized neutrons with {sup 10}B nuclei in the targeted tumor. For BNCT of brain tumors, it is crucial that {sup 10}B concentrations in radiosensitive regions of the brain be minimal since malignant cells and vital brain tissues are often inter-mingled at the margins of the tumor. Currently, boronophenylalanine [BPA]-mediated BNCT is undergoing preliminary clinical study for postoperative radiotherapy of glioblastorna multiforme at Brookhaven National Laboratory. Investigators in Japan are developing {sup 18}F-fluoroboronophenylaianine [FBPA] as a positron {sup 18}F (T{sub 1/2} = 110 min), which is usually emission tomography [PET] surrogate for BPA. generated at a cyclotron dedicated to PET, is generally a minimally perturbing substitute for the 2-H on the aromatic ring because of its small size and the strong covalent bond it forms with carbon. However, SPECT has potential advantages over PET: (1) SPECT is clinically more widely available at lower cost; (2) most radioisotopes for the synthesis of SPECT agents can be purchased; (3) SPECT is less difficult to implement. It is thought that the quality of images derived from the two techniques would each be sufficiently informative for BNCT treatment planning purposes, provided that the SPECT and PET agents being considered were both pharmacokinetic surrogates for BPA. This study evaluated the use of {sup 123}I alpha methyltyrosine as a surrogate for BPA in BNCT.

  2. Estrogenic Effects of Several BPA Analogs in the Developing Zebrafish Brain

    PubMed Central

    Cano-Nicolau, Joel; Vaillant, Colette; Pellegrini, Elisabeth; Charlier, Thierry D.; Kah, Olivier; Coumailleau, Pascal

    2016-01-01

    Important set of studies have demonstrated the endocrine disrupting activity of Bisphenol A (BPA). The present work aimed at defining estrogenic-like activity of several BPA structural analogs, including BPS, BPF, BPAF, and BPAP, on 4- or 7-day post-fertilization (dpf) zebrafish larva as an in vivo model. We measured the induction level of the estrogen-sensitive marker cyp19a1b gene (Aromatase B), expressed in the brain, using three different in situ/in vivo strategies: (1) Quantification of cyp19a1b transcripts using RT-qPCR in wild type 7-dpf larva brains exposed to bisphenols; (2) Detection and distribution of cyp19a1b transcripts using in situ hybridization on 7-dpf brain sections (hypothalamus); and (3) Quantification of the cyp19a1b promoter activity in live cyp19a1b-GFP transgenic zebrafish (EASZY assay) at 4-dpf larval stage. These three different experimental approaches demonstrated that BPS, BPF, or BPAF exposure, similarly to BPA, significantly activates the expression of the estrogenic marker in the brain of developing zebrafish. In vitro experiments using both reporter gene assay in a glial cell context and competitive ligand binding assays strongly suggested that up-regulation of cyp19a1b is largely mediated by the zebrafish estrogen nuclear receptor alpha (zfERα). Importantly, and in contrast to other tested bisphenol A analogs, the bisphenol AP (BPAP) did not show estrogenic activity in our model. PMID:27047331

  3. Estrogenic Effects of Several BPA Analogs in the Developing Zebrafish Brain.

    PubMed

    Cano-Nicolau, Joel; Vaillant, Colette; Pellegrini, Elisabeth; Charlier, Thierry D; Kah, Olivier; Coumailleau, Pascal

    2016-01-01

    Important set of studies have demonstrated the endocrine disrupting activity of Bisphenol A (BPA). The present work aimed at defining estrogenic-like activity of several BPA structural analogs, including BPS, BPF, BPAF, and BPAP, on 4- or 7-day post-fertilization (dpf) zebrafish larva as an in vivo model. We measured the induction level of the estrogen-sensitive marker cyp19a1b gene (Aromatase B), expressed in the brain, using three different in situ/in vivo strategies: (1) Quantification of cyp19a1b transcripts using RT-qPCR in wild type 7-dpf larva brains exposed to bisphenols; (2) Detection and distribution of cyp19a1b transcripts using in situ hybridization on 7-dpf brain sections (hypothalamus); and (3) Quantification of the cyp19a1b promoter activity in live cyp19a1b-GFP transgenic zebrafish (EASZY assay) at 4-dpf larval stage. These three different experimental approaches demonstrated that BPS, BPF, or BPAF exposure, similarly to BPA, significantly activates the expression of the estrogenic marker in the brain of developing zebrafish. In vitro experiments using both reporter gene assay in a glial cell context and competitive ligand binding assays strongly suggested that up-regulation of cyp19a1b is largely mediated by the zebrafish estrogen nuclear receptor alpha (zfERα). Importantly, and in contrast to other tested bisphenol A analogs, the bisphenol AP (BPAP) did not show estrogenic activity in our model. PMID:27047331

  4. Administrative IT

    ERIC Educational Resources Information Center

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  5. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  6. ADMINISTRATIVE CLIMATE.

    ERIC Educational Resources Information Center

    BRUCE, ROBERT L.; CARTER, G.L., JR.

    IN THE COOPERATIVE EXTENSION SERVICE, STYLES OF LEADERSHIP PROFOUNDLY AFFECT THE QUALITY OF THE SERVICE RENDERED. ACCORDINGLY, MAJOR INFLUENCES ON ADMINISTRATIVE CLIMATE AND EMPLOYEE PRODUCTIVITY ARE EXAMINED IN ESSAYS ON (1) SOURCES OF JOB SATISFACTION AND DISSATISFACTION, (2) MOTIVATIONAL THEORIES BASED ON JOB-RELATED SATISFACTIONS AND NEEDS,…

  7. Database Administrator

    ERIC Educational Resources Information Center

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  8. Photocatalytic degradation of Bisphenol A (BPA) using immobilized TiO2 and UV illumination in a horizontal circulating bed photocatalytic reactor (HCBPR).

    PubMed

    Wang, Rongchang; Ren, Dianjun; Xia, Siqing; Zhang, Yalei; Zhao, Jianfu

    2009-09-30

    Photocatalytic degradation of Bisphenol A (BPA) in the presence of titanium dioxide (TiO(2)) and ultraviolet (UV) illumination was performed in a self-designed horizontal circulating bed photocatalytic reactor (HCBPR). TiO(2) catalyst was immobilized on the surface of polyurethane foam (PF) cubes via microwave-assisted liquid phase deposition. The effects of initial BPA concentration, initial pH, TiO(2) dosage and temperature on BPA photodegradation were investigated in order to obtain the optimum operational conditions. The results reveal that the BPA degradation efficiency can be effectively improved by increasing pH from 3.4 to 12.3 or decreasing the initial BPA concentration from 50 to 10 ppm. The optimum TiO(2) carrier dosage (the ratio of the volume of PF carriers to the effective reaction volume of HCBPR) was about 1%. Besides, the effect of temperature on BPA photodegradation was found to be unremarkable in the range of 21.2-30.5 degrees C. Total organic carbon (TOC) was used to evaluate the mineralization of BPA during the photodegradation process. Under the optimum conditions, 95% removal of TOC and 97% removal of BPA can be achieved after 6h of UV radiation, which demonstrates the high photodegradation efficiency of BPA in HCBPR. PMID:19500904

  9. The Molecular Mechanism of Bisphenol A (BPA) as an Endocrine Disruptor by Interacting with Nuclear Receptors: Insights from Molecular Dynamics (MD) Simulations

    PubMed Central

    Li, Lanlan; Wang, Qianqian; Zhang, Yan; Niu, Yuzhen; Yao, Xiaojun; Liu, Huanxiang

    2015-01-01

    Bisphenol A (BPA) can interact with nuclear receptors and affect the normal function of nuclear receptors in very low doses, which causes BPA to be one of the most controversial endocrine disruptors. However, the detailed molecular mechanism about how BPA interferes the normal function of nuclear receptors is still undiscovered. Herein, molecular dynamics simulations were performed to explore the detailed interaction mechanism between BPA with three typical nuclear receptors, including hERα, hERRγ and hPPARγ. The simulation results and calculated binding free energies indicate that BPA can bind to these three nuclear receptors. The binding affinities of BPA were slightly lower than that of E2 to these three receptors. The simulation results proved that the binding process was mainly driven by direct hydrogen bond and hydrophobic interactions. In addition, structural analysis suggested that BPA could interact with these nuclear receptors by mimicking the action of natural hormone and keeping the nuclear receptors in active conformations. The present work provided the structural evidence to recognize BPA as an endocrine disruptor and would be important guidance for seeking safer substitutions of BPA. PMID:25799048

  10. BPA and NP removal from municipal wastewater by tropical horizontal subsurface constructed wetlands.

    PubMed

    Toro-Vélez, A F; Madera-Parra, C A; Peña-Varón, M R; Lee, W Y; Bezares-Cruz, J C; Walker, W S; Cárdenas-Henao, H; Quesada-Calderón, S; García-Hernández, H; Lens, P N L

    2016-01-15

    It has been recognized that numerous synthetic compounds like Bisphenol A (BPA) and nonylphenols (NP) are present in effluents from wastewater treatment plants (WWTP) at levels of parts per billion (μg L(-1)) or even parts per trillion (ng L(-1)) with a high potential to cause endocrine disruption in the aquatic environment. Constructed wetlands (CW) are a cost-effective wastewater treatment alternative with promising performance to treat these afore mentioned compounds. This research was aimed to evaluate the efficacy of CW treatment of WWTP effluent for mitigating the effects endocrine disrupting compounds (EDCs). This research goal was accomplished by (1) quantifying the removal of BPA and NP in CWs; (2) isolating CW fungal strains and testing for laccase production; and (3) performing endocrine disruption (reproduction) bioassays using the fruit fly Drosophila melanogaster. Three pilot scale horizontal subsurface flow constructed wetlands (HSSF-CW) were operated for eight weeks: one planted with Phragmites australis; one planted with Heliconia psitacorum; and one unplanted. The Heliconia CW showed a removal efficiency of 73.3(± 19%) and 62.8(± 20.1%) for BPA and NP, respectively; while the Phragmites CW demonstrated a similar removal for BPA (70.2 ± 27%) and lower removal efficiency for NP 52.1(± 37.1%).The unplanted CW achieved 62.2 (± 33%) removal for BPA and 25.3(± 37%) removal for NP. Four of the eleven fungal strains isolated from the Heliconia-CW showed the capacity to produce laccase. Even though complete removal of EDCs was not achieved by the CWs, the bioassay confirmed a significant improvement (p < 0.05) in fly viability for all CWs, with Heliconia sp. being the most effective at mitigating adverse effects on first and second generational reproduction. This study showed that a CW planted with a native Heliconia sp. CW demonstrated a higher removal of endocrine disrupting compounds and better mitigation of reproductive disruption in the

  11. Research Proposal for the Design and Engineering Phase of a Solar Heating and Cooling System Experiment at the Warner Robins Public Library, Warner Robins, Georgia. Submitted to the United States Energy Research and Development Administration.

    ERIC Educational Resources Information Center

    Phillips, Warren H.; And Others

    A number of reasons are advanced to include a solar heating and cooling experiment in a library building. The unique aspects of the experiment are to be a seasonally adjustable collector tilt and testing of a new generation of absorption air conditioners. After a brief description of the proposed experiment, the proposal contains forms filed by…

  12. Faculty Perspectives on Administrator Effectiveness.

    ERIC Educational Resources Information Center

    Bess, James L.

    The sources of faculty perspectives on the personal effectiveness of administrators are analyzed. It is proposed that faculty will be predisposed to see administrators in different lights, depending on structural elements in decision making and the orientation of the faculty members. Attention is directed to Talcott Parson's theory for classifying…

  13. Temporal trends in bisphenol A exposure in the United States from 2003-2012 and factors associated with BPA exposure: Spot samples and urine dilution complicate data interpretation.

    PubMed

    LaKind, Judy S; Naiman, Daniel Q

    2015-10-01

    Nationally representative data on urinary levels of BPA and its metabolites in the United States from the 2003-2004 to 2011-2012 National Health and Nutrition Examination Surveys (NHANES) were used to estimate daily BPA intakes and examine temporal trends. Additionally, NHANES data on lifestyle/demographic/dietary factors previously reported to be associated with BPA exposures were examined to assess the resiliency of the reported associations (whether the association is maintained across the five surveys). Finally, various approaches for addressing issues with the use of BPA concentration data from spot urine samples were examined for their effect on trends and associations. Three approaches were assessed here: (i) use of generic literature-based 24-h urine excretion volumes, (ii) use of creatinine adjustments, and (iii) use of individual urine flow rate data from NHANES. Based on 2011-2012 NHANES urinary BPA data and assumptions described in this paper, the median daily intake for the overall population is approximately 25 ng/kg day; median intake estimates were approximately two to three orders of magnitude below current health-based guidance values. Estimates of daily BPA intake have decreased significantly compared to those from the 2003-2004 NHANES. Estimates of associations between lifestyle/demographic/dietary factors and BPA exposure revealed inconsistencies related to both NHANES survey year and the three approaches listed above; these results demonstrate the difficulties in interpreting urinary BPA data, despite efforts to account for urine dilution and translation of spot sample data to 24-h data. The results further underscore the importance of continued research on how to best utilize urinary measures of environmental chemicals in exposure research. Until a consensus is achieved regarding the best biomonitoring approaches for assessing exposures to short-lived chemicals using urine samples, research on factors associated with BPA exposures should

  14. Bacterial Proteasome Activator Bpa (Rv3780) Is a Novel Ring-Shaped Interactor of the Mycobacterial Proteasome

    PubMed Central

    Delley, Cyrille L.; Laederach, Juerg; Ziemski, Michal; Bolten, Marcel; Boehringer, Daniel; Weber-Ban, Eilika

    2014-01-01

    The occurrence of the proteasome in bacteria is limited to the phylum of actinobacteria, where it is maintained in parallel to the usual bacterial compartmentalizing proteases. The role it plays in these organisms is still not fully understood, but in the human pathogen Mycobacterium tuberculosis (Mtb) the proteasome supports persistence in the host. In complex with the ring-shaped ATPase Mpa (called ARC in other actinobacteria), the proteasome can degrade proteins that have been post-translationally modified with the prokaryotic ubiquitin-like protein Pup. Unlike for the eukaryotic proteasome core particle, no other bacterial proteasome interactors have been identified to date. Here we describe and characterize a novel bacterial proteasome activator of Mycobacterium tuberculosis we termed Bpa (Rv3780), using a combination of biochemical and biophysical methods. Bpa features a canonical C-terminal proteasome interaction motif referred to as the HbYX motif, and its orthologs are only found in those actinobacteria encoding the proteasomal subunits. Bpa can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome. Using negative-stain electron microscopy, we show that Bpa forms a ring-shaped homooligomer that can bind coaxially to the face of the proteasome cylinder. Interestingly, Bpa can stimulate the proteasomal degradation of the model substrate β-casein, which suggests it could play a role in the removal of non-native or damaged proteins. PMID:25469515

  15. Environmental Assessment on BPA's Proposed Funding of Lower Umatilla River Anadromous Salmonid Passage Enhancement Projects, FY 1983.

    SciTech Connect

    United States. Bonneville Power Administration.

    1983-07-01

    The major factors presently restricting fall and spring chinook reintroduction are the lack of adequate streamflows during spawning migration and resulting passage difficulties in the lower River and at Three Mile Falls. Maxwell and Cold Springs Diversion dams are also potential passage barriers during low flow years. In order to get fish past diversion structures and over shallow river bars, biologists generally feel that a minimum streamflow of 250-300 ft/sup 3/s is needed in September, October, November, May and June from the mouth of McKay Creek downstream to provide adequate transportation and spawning flow for adult fall and spring chinook. Three Mile Falls Diversion Dam is the highest diversion facility on the Umatilla River and is a formidable obstacle to anadromous fish. The lip of the dam passes a uniform flow over the crest, and fish are not necessarily attracted to the fish ladder entrance. While attempting to jump over the dam, adult steelhead have become trapped in the dam's buttress bays. Modification of the dam's passage facilities and the immediate downstream area would provide additional capacity to pass fish migration flows when water is available, improved screens and fish ladder accessibility, and a better defined channel by which the migrants can reach the fish ladders. 24 figs.

  16. 77 FR 18799 - Proposed Agency Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    .... Environmental Protection Agency (EPA) sponsored questions related to water use on the 2007 CBECS. The water.... Energy Information Administration Proposed Agency Information Collection AGENCY: U.S. Energy Information Administration (EIA), Department of Energy (DOE). ACTION: Agency Information Collection Activities:...

  17. 77 FR 57080 - Proposed Agency Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... Information Administration Proposed Agency Information Collection AGENCY: U.S. Energy Information Administration (EIA), U.S. Department of Energy. ACTION: Agency Information Collection Activities: Proposed... 1995. Comments are invited on: (a) Whether the proposed collection of information is necessary for...

  18. Comparative study of the effect of BPA and its selected analogues on hemoglobin oxidation, morphological alterations and hemolytic changes in human erythrocytes.

    PubMed

    Maćczak, Aneta; Bukowska, Bożena; Michałowicz, Jaromir

    2015-01-01

    Bisphenol A (BPA) has been shown to provoke many deleterious impacts on human health, and thus it is now successively substituted by BPA analogues, whose effects have been poorly investigated. Up to now, only one study has been realized to assess the effect of BPA on human erythrocytes, which showed its significant hemolytic and oxidative potential. Moreover, no study has been conducted to evaluate the effect of BPA analogues on red blood cells. The purpose of the present study was to compare the impact of BPA and its selected analogues such as bisphenol F (BPF), bisphenol S (BPS) and bisphenol AF (BPAF) on hemolytic and morphological changes and hemoglobin oxidation (methemoglobin formation) of human erythrocytes. The erythrocytes were incubated with different bisphenols concentrations ranging from 0.5 to 500μg/ml for 1, 4 and 24h. The compounds examined caused hemolysis in human erythrocytes with BPAF exhibiting the strongest effect. All bisphenols examined caused methemoglobin formation with BPA inducing the strongest oxidative potential. Flow cytometry analysis showed that all bisphenols (excluding BPS) induced significant changes in erythrocytes size. Changes in red blood cells shape were conducted using phase contrast microscopy. It was noticed that BPA and BPAF induced echinocytosis, BPF caused stomatocytosis, while BPS did not provoke significant changes in shape of red blood cells. Generally, the results showed that BPS, which is the main substituent of bisphenol A in polymers and thermal paper production, exhibited significantly lower disturbance of erythrocyte functions than BPA. PMID:26232583

  19. EVALUATION OF ORAL AND INTRAVENOUS ROUTE PHARMACOKINETICS, PLASMA PROTEIN BINDING AND UTERINE TISSUE DOSE METRICS OF BPA: A PHYSIOLOGICALLY BASED PHARMACOKINETIC APPROACH

    EPA Science Inventory

    Bisphenol A (BPA) is a weakly estrogenic monomer used in the production of polycarbonate plastics and epoxy resins, both of which are used in food contact applications. A physiologically based pharmacokinetic (PBPK) model of BPA pharmacokinetics in rats and humans was developed t...

  20. Cu-PDC-bpa solid coordination frameworks (PDC=2,5-pyrindinedicarboxylate; bpa=1,2-DI(4-pyridil)ethane)): 2D and 3D structural flexibility producing a 3-c herringbone array next to ideal

    SciTech Connect

    Llano-Tomé, Francisco; Bazán, Begoña; Urtiaga, Miren-Karmele; Barandika, Gotzone; Antonia Señarís-Rodríguez, M.; and others

    2015-10-15

    Combination of polycarboxylate anions and dipyridyl ligands is an effective strategy to produce solid coordination frameworks (SCF) which are crystalline materials based on connections between metal ions through organic ligands. In this context, this work is focused on two novel Cu{sup II}-based SCFs exhibiting PDC (2,5-pyridinedicarboxylate) and bpa (1,2-di(4-pyridyl)ethane), being the first structures reported in literature containing both ligands. Chemical formula are [Cu{sub 2}[(PDC){sub 2}(bpa)(H{sub 2}O){sub 2}]·3H{sub 2}O·DMF (1), and [Cu{sub 2}(PDC){sub 2}(bpa)(H{sub 2}O){sub 2}]·7H{sub 2}O (2), where DMF is dimethylformamide. Compounds 1 and 2 have been characterized by means of X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric (TG) analysis, differential thermal analysis (DTA) and dielectric measurements. The crystallographic analysis revealed that compounds 1 and 2 can be described as herringbone-type layers formed by helicoidal Cu-PDC-Cu chains connected through bpa ligands. Solvent molecules are crystallized between the layers, providing the inter-layer connections through hydrogen bonds. Differences between both compounds are attributable to the flexibility of bpa (in 2D) as well as to the 3D packing of the layers which is solvent dependent. This fact results in the fact that compound 2 is the most regular 3-c herringbone array reported so far. The structural dynamism of these networks is responsible for the crystalline to-amorphous to-crystalline (CAC) transformation from compound 1 to compound 2. Crystallochemical features for both compounds have also been studied and compared to similar 3-connected herringbone-arrays. - Graphical abstract: Cu-PDC-bpa 3-c herringbone arrays. - Highlights: • The most ideal herringbone array reported so far is a Cu-PDC-bpa SCF. • Conformational freedom of bpa results in 2D and 3D flexibility of the SCFs. • The flexibility of the SCFs is related to a phase transformation. • Dielectric

  1. Space station proposed

    NASA Astrophysics Data System (ADS)

    In his State of the Union address on January 25, President Ronald Reagan announced that he was directing the National Aeronautics and Space Administration (NASA) to “develop a permanently manned space station, and to do it within a decade.”Included in the NASA budget proposal sent to Congress the following week was $150 million for the station. This is the first request of many; expected costs will total roughly $8 billion by the early 1990's.

  2. Paternal BPA exposure in early life alters Igf2 epigenetic status in sperm and induces pancreatic impairment in rat offspring.

    PubMed

    Mao, Zhenxing; Xia, Wei; Chang, Huailong; Huo, Wenqian; Li, Yuanyuan; Xu, Shunqing

    2015-11-01

    Exposure to endocrine disruptors in utero appears to alter epigenetics in the male germ-line and subsequently promote adult-onset disease in subsequent generations. Fetal exposure to bisphenol A (BPA), a highly prevalent endocrine disruptor in environment, has been shown to alter epigenetic modification and result in glucose intolerance in adulthood. However, whether fetal exposure to BPA can induce epigenetic modification and phenotypic changes in their subsequent offspring are still unclear. The present study was designed to investigate whether exposure to BPA in early life induced glucose intolerance in the offspring through male germ line, and the underlying epigenetic molecular basis. F0 pregnant SD rats were received corn oil or 40 μg/kg/day of BPA during gestation and lactation. F1 male rats were maintained to generate F2 offspring by mating with untreated female rats. Both the F1 rats after weaning and the F2 offspring were not received any other treatments. Our results showed that male F2 offspring in the BPA group exhibited glucose intolerance and β-cell dysfunction. Decreased expression of Igf2 and associated hypermethylation of Igf2 were observed in islets of male F2 offspring. In addition, similar effects were observed in female F2 animals, but the effects were more pronounced in males. Moreover, abnormal expression and methylation of Igf2 was observed in sperm of adult F1 male rats, indicating that epigenetic modification in germ cells can be partly progressed to the next generation. Overall, our study suggests that BPA exposure during early life can result in generational transmission of glucose intolerance and β-cell dysfunction in the offspring through male germ line, which is associated with hypermethylation of Igf2 in islets. The changes of epigenetics in germ cells may contribute to this generational transmission. PMID:26276081

  3. Migration of bisphenol A (BPA) from epoxy can coatings to jalapeño peppers and an acid food simulant.

    PubMed

    Munguia-Lopez, Elvia M; Peralta, Elizabeth; Gonzalez-Leon, Alberto; Vargas-Requena, Claudia; Soto-Valdez, Herlinda

    2002-12-01

    Effects of heat processing, storage time, and temperature on migration of bisphenol A (BPA) from an epoxy type can coating to an acid food simulant and jalapeño peppers were determined. Commercial jalapeño pepper cans (8 oz, dimensions 211 x 300) were stored at 25 degrees C for 40, 70, and 160 days. A solution of 3% acetic acid was canned in 211 x 300 cans from the same batch used for jalapeño peppers. Heat processing was applied to two-thirds of the cans, and the remaining cans were not heat processed. Cans were stored at 25 and 35 degrees C for 0, 40, 70, and 160 days. Results showed that there is a minimal effect of heat treatment. An effect of storage time on migration of BPA during the first 40 days at 25 degrees C was observed. An increase on migration of BPA was observed with storage time at 35 degrees C. The highest level of migration was 15.33 microg/kg of BPA at 160 days at 35 degrees C. A correction factor of approximately 0.4 was calculated for migration under simulating conditions of storage compared to the real ones. The highest level of BPA found in jalapeño peppers cans, surveyed from three supermarkets, was 5.59 +/- 2.43 microg/kg. Migration of BPA, performed according to the European and Mercosur conditions, was 65.45 +/- 5.29 microg/kg. All the migration values found in this study were below those legislation limits (3 mg/kg). PMID:12452648

  4. F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck.

    PubMed

    Li, Gengqi; Chang, Huailong; Xia, Wei; Mao, Zhenxing; Li, Yuanyuan; Xu, Shunqing

    2014-08-01

    BPA, a common environmental endocrine disruptor, has been reported to induce epigenetic changes and disrupt glucose homeostasis in F1 offspring through maternal exposure. However, no studies have examined whether maternal BPA exposure can exert multigenerational effects of glucose metabolic disorder on F2 generation through the altered epigenetic information. The aim of the current study was to investigate whether BPA exposure can disrupt glucose homeostasis in F2 offspring and the underlying epigenetic mechanism. In the present study, F0 pregnant dams were orally administered at a daily dose of 40μg/kg body weight during gestation and lactation. The F1 and F2 generations were obtained and not exposed to BPA anymore. The glucose and insulin tolerance tests were carried out to evaluate the glucose homeostasis level. The relative hormone level and the relative gene expression were also examined. F2 generation was found to exhibited glucose intolerance and insulin resistance in ipGTT and ipITT, as well as the downregulation of glucokinase (Gck) gene in liver. DNA methylation pattern of Gck promoter in the F2 generation of hepatic tissue and F1 generation of sperm was then performed. The Gck promoter in F2 hepatic tissue became completely methylated in the all CpG sites compared with five unmethylated sites in controls. In the F1 sperm, the global DNA methylation was decreased. However, there is only CpG site -314 was differently methylated between BPA and controls in sperm. In conclusion, F0 maternal BPA exposure during gestation and lactation can induce impaired glucose homeostasis in the F2 offspring through the transmission of sperm. The underlying epigenetic modifications in the sperm of F1 generation remain to be further elucidated. PMID:24793715

  5. Using Ensemble Streamflows for Power Marketing at Bonneville Power Administration

    NASA Astrophysics Data System (ADS)

    Barton, S. B.; Koski, P.

    2014-12-01

    Bonneville Power Administration (BPA) is a federal non-profit agency within the Pacific Northwest responsible for marketing the power generated from 31 federal hydro projects throughout the Columbia River Basin. The basin encompasses parts of five states and portions of British Columbia, Canada. BPA works with provincial entities, federal and state agencies, and tribal members to manage the water resources for a variety of purposes including flood risk management, power generation, fisheries, irrigation, recreation, and navigation. This basin is subject to significant hydrologic variability in terms of seasonal volume and runoff shape from year to year which presents new water management challenges each year. The power generation planning group at BPA includes a team of meteorologists and hydrologists responsible for preparing both short-term (up to three weeks) and mid-term (up to 18 months) weather and streamflow forecasts including ensemble streamflow data. Analysts within the mid-term planning group are responsible for running several different hydrologic models used for planning studies. These models rely on these streamflow ensembles as a primary input. The planning studies are run bi-weekly to help determine the amount of energy available, or energy inventory, for forward marketing (selling or purchasing energy up to a year in advance). These studies are run with the objective of meeting the numerous multi-purpose objectives of the basin under the various streamflow conditions within the ensemble set. In addition to ensemble streamflows, an ensemble of seasonal volume forecasts is also provided for the various water conditions in order to set numerous constraints on the system. After meeting all the various requirements of the system, a probabilistic energy inventory is calculated and used for marketing purposes.

  6. SIMS ion microscopy imaging of boronophenylalanine (BPA) and 13C15N-labeled phenylalanine in human glioblastoma cells: Relevance of subcellular scale observations to BPA-mediated boron neutron capture therapy of cancer

    NASA Astrophysics Data System (ADS)

    Chandra, Subhash; Lorey, Daniel R., II

    2007-02-01

    p-Boronophenylalanine (BPA) is a clinically approved boron neutron capture therapy (BNCT) agent currently being used in clinical trials of glioblastoma multiforme, melanoma and liver metastases. Secondary ion mass spectrometry (SIMS) observations from the Cornell SIMS Laboratory provided support for using a 6 h infusion of BPA, instead of a 2 h infusion, for achieving higher levels of boron in brain tumor cells. These observations were clinically implemented in Phase II experimental trials of glioblastoma multiforme in Sweden. However, the mechanisms for higher BPA accumulation with longer infusions have remained unknown. In this work, by using 13C15N-labeled phenylalanine and T98G human glioblastoma cells, comparisons between the 10B-delivery of BPA and the accumulation of labeled phenylalanine after 2 and 6 h treatments were made with a Cameca IMS-3f SIMS ion microscope at 500 nm spatial resolution in fast frozen, freeze-fractured, freeze-dried cells. Due to the presence of the Na-K-ATPase in the plasma membrane of most mammalian cells, the cells maintain an approximately 10/1 ratio of K/Na in the intracellular milieu. Therefore, the quantitative imaging of these highly diffusible species in the identical cell in which the boron or labeled amino acid was imaged provides a rule-of-thumb criterion for validation of SIMS observations and the reliability of the cryogenic sampling. The labeled phenylalanine was detected at mass 28, as the 28(13C15N)- molecular ion. Correlative analysis with optical and confocal laser scanning microscopy revealed that fractured freeze-dried glioblastoma cells contained well-preserved ultrastructural details with three discernible subcellular regions: a nucleus or multiple nuclei, a mitochondria-rich perinuclear cytoplasmic region and the remaining cytoplasm. SIMS analysis revealed that the overall cellular signals of both 10B from BPA and 28CN- from labeled phenylalanine increased approximately 1.6-fold between the 2 and 6 h exposures

  7. Program Proposal

    ERIC Educational Resources Information Center

    Baskas, Richard S.

    2012-01-01

    A study was conducted to determine if a deficiency, or learning gap, existed in a particular working environment. To determine if an assessment was to be conducted, a program proposal would need to be developed to explore this situation. In order for a particular environment to react and grow with other environments, it must be able to take on…

  8. Industry Raps OSHA's Proposed Cancer Policy

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1978

    1978-01-01

    Presents the response of the American Industrial Health Council (AIHC) to the Occupational Safety and Health Administration's (OSHA's) genetic proposal for regulating chemical carcinogens in industry. (HM)

  9. Is container type the biggest predictor of trace element and BPA leaching from drinking water bottles?

    PubMed

    Rowell, Candace; Kuiper, Nora; Preud'Homme, Hugues

    2016-07-01

    The knowledge-base of bottled water leachate is highly contradictory due to varying methodologies and limited multi-elemental and/or molecular analyses; understanding the range of contaminants and their pathways is required. This study determined the leaching potential and leaching kinetics of trace elements, using consistent comprehensive quantitative and semi-quantitative (79 elements total) analyses, and BPA, using isotopic dilution and MEPS pre-concentration with UHPLC-ESI-QTOF. Statistical methods were used to determine confounders and predictors of leaching and human health risk throughout 12days of UV exposure and after exposure to elevated temperature. Various types of water were used to assess the impact of water quality. Results suggest Sb leaching is primarily dependent upon water quality, not container type. Bottle type is a predictor of elemental leaching for Pb, Ba, Cr, Cu, Mn and Sr; BPA was detected in samples from polycarbonate containers. Health risks from the consumption of bottled water increase after UV exposure. PMID:26920269

  10. Qualitative assessment of the impacts of proposed system operating strategies to resident fish within selected Columbia River Reservoirs

    SciTech Connect

    Shreffler, D.K.; Geist, D.R.; Mavros, W.V.

    1994-01-01

    The Bonneville Power Administration (BPA), Bureau of Reclamation (BOR), and US Army Corps of Engineers (COE) are presently conducting the System Operation Review (SOR) for the Columbia River basin. The SOR began in 1990 and is expected to provide an operating strategy that will take into consideration multiple uses of the Columbia River system including navigation, flood control, irrigation, power generation, fish migration, fish and wildlife habitat, recreation, water supply, and water quality. This report provides descriptions of each of the non-modeled reservoirs and other specified river reaches. The descriptions focus on the distinct management goals for resident fish: biodiversity, species-specific concerns, and sport fisheries. In addition, this report provides a qualitative assessment of impacts to the resident fish within these reservoirs and river reaches from the 7 alternative system operating strategies. In addition to this introduction, the report contains four more sections. Section 2.0 provides the methods that were used. Reservoir descriptions appear in Section 3.0, which is a synthesis of our literature review and interviews with resident fish experts. Section 4.0 contains a discussion of potential impacts to fish within each of these reservoirs and river reaches from the 7 proposed system operating strategies. The references cited are listed in Section 5.0.

  11. 78 FR 25954 - Endangered and Threatened Species; Take of Anadromous Fish

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... pursuant to the National Environmental Policy Act (NEPA) by the Bonneville Power Administration (BPA) for... Springfield Hatchery. Because the BPA action is substantially the same as the actions addressed by the... Hatchery Master Plan, NMFS proposes to adopt the BPA environmental assessment to comply with the...

  12. 78 FR 28805 - Endangered and Threatened Species; Take of Anadromous Fish

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... pursuant to the National Environmental Policy Act (NEPA) by the Bonneville Power Administration (BPA) for... Springfield Hatchery. Because the BPA action is substantially the same as the actions addressed by the... Hatchery Master Plan, NMFS proposes to adopt the BPA environmental assessment to comply with the...

  13. 77 FR 66963 - Public Hearing and Opportunities for Public Review and Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ...: Bonneville Power Administration (BPA), Department of Energy (DOE). ACTION: Notice of Proposed 2014 Oversupply Rates. SUMMARY: On March 6, 2012, BPA filed its Oversupply Management Protocol with the Federal Energy Regulatory Commission (Docket No. EL11-44) as an amendment to BPA's Open Access Transmission Tariff....

  14. Mechanistic study of photo-oxidation of Bisphenol-A (BPA) with hydrogen peroxide (H2O2) and sodium persulfate (SPS).

    PubMed

    Sharma, Jyoti; Mishra, I M; Kumar, Vineet

    2016-01-15

    The removal of Bisphenol-A (BPA) from contaminated water using advanced oxidation methods such as UV-C assisted oxidation by hydrogen peroxide (H2O2) and sodium persulfate (SPS) has been reported by the authors earlier (Sharma et al., 2015a). In the present study, the authors report the removal of BPA from aqueous solution by the above two methods and its degradation mechanism. UV-C light (254 nm wavelength, 40 W power) was applied to BPA contaminated water at natural pH (pHN) under room temperature conditions. Experiments were carried out with the initial BPA concentration in the range of 0.04 mM-0.31 mM and the oxidant/BPA molar ratio in the range of 294:1-38:1 for UV-C/H2O2 and 31.5-4.06:1 for UV-C/SPS systems. The removal of BPA enhanced with decreasing BPA concentration. The total organic carbon also decreased with the UV-C irradiation time under optimum conditions ([H2O2]0 = 11.76 mM; [SPS]0 = 1.26 mM; temperature (29 ± 3 °C). Competition of BPA for reaction with HO or [Formula: see text] radicals at its higher concentrations results in a decrease in the removal of BPA. The intermediates with smaller and higher molecular weights than that of BPA were found in the treated water. Based on GC-MS and FTIR spectra of the reaction mixture, the formation of hydroxylated by-products testified the HO mediated oxidation pathway in the BPA degradation, while the formation of quinones and phenoxy phenols pointed to the [Formula: see text] dominating pathway through the formation of hydroxycyclohexadienyl (HCHD) and BPA phenoxyl radicals. The main route of BPA degradation is the hydroxylation followed by dehydration, coupling and ring opening reactions. PMID:26468603

  15. Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA), 4-Methyl-2,4-bis-(P-Hydroxyphenyl)Pent-1-Ene—A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight

    PubMed Central

    Rehan, Mohd; Ahmad, Ejaz; Sheikh, Ishfaq A.; Abuzenadah, Adel M.; Damanhouri, Ghazi A.; Bajouh, Osama S.; AlBasri, Samera F.; Assiri, Mansour M.; Beg, Mohd A.

    2015-01-01

    Exposure to toxic industrial chemicals that have capacity to disrupt the endocrine system, also known as endocrine disrupting chemicals (EDCs), has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyl)diphenol) and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutyl)phenol) are among the most common environmental contaminants possessing endocrine disruption properties and are present in plastics, epoxy resins, detergents and other commercial products of common personal and industrial use. A metabolite of BPA, 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) is about 1000 times more biologically active compared to BPA. Epidemiological, clinical, and experimental studies have shown association of BPA and OP with adverse effects on male and female reproductive system in human and animals. The endocrine disruption activity can occur through multiple pathways including binding to steroid receptors. Androgen receptor (AR) and progesterone receptor (PR) are critical for reproductive tract growth and function. Structural binding characterization of BPA, MBP, and OP with AR and PR using molecular docking simulation approaches revealed novel interactions of BPA with PR, and MBP and OP with AR and PR. For BPA, MBP, and OP, five AR interacting residues Leu-701, Leu-704, Asn-705, Met-742, and Phe-764 overlapped with those of native AR ligand testosterone, and four PR interacting residues Leu-715, Leu-718, Met-756, and Met-759 overlapped with those of PR co-complex ligand, norethindrone. For both the receptors the binding strength of MBP was maximum among the three compounds. Thus, these compounds have the potential to block or interfere in the binding of the endogenous native AR and PR ligands and, hence, resulting in dysfunction. The knowledge of the key interactions and the important amino-acid residues also allows better prediction of potential of xenobiotic molecules for disrupting AR- and PR

  16. 76 FR 11835 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA... . (SSA) Social Security Administration, DCBFM, Attn: Reports Clearance Officer, 1333 Annex Building,...

  17. 77 FR 62593 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA... . (SSA) Social Security Administration, DCRDP, Attn: Reports Clearance Director, 107 Altmeyer...

  18. 75 FR 4606 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA....gov . (SSA), Social Security Administration, DCBFM, Attn: Reports Clearance Officer, 1340...

  19. 78 FR 26843 - Agency Information Collection Activities; Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities; Proposed Request The Social Security Administration (SSA... . (SSA) Social Security Administration, DCRDP, Attn: Reports Clearance Director, 107 Altmeyer...

  20. 77 FR 62592 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA... . (SSA) Social Security Administration, DCRDP, Attn: Reports Clearance Director, 107 Altmeyer...

  1. 77 FR 20007 - Proposed Information Collection; Comment Request; Property Management

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... Economic Development Administration Proposed Information Collection; Comment Request; Property Management AGENCY: Economic Development Administration (EDA). ACTION: Notice. SUMMARY: The Department of Commerce... 7009, Economic Development Administration, Washington, DC 20230, telephone (202) 482-0951,...

  2. 78 FR 65745 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA... ; (SSA), Social Security Administration, DCRDP, Attn: Reports Clearance Director, 107 Altmeyer...

  3. 78 FR 59411 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA... . (SSA), Social Security Administration, DCRDP, Attn: Reports Clearance Director, 107 Altmeyer...

  4. 75 FR 69515 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA....gov . (SSA) Social Security Administration, DCBFM, Attn: Reports Clearance Officer, 1333...

  5. Cu-PDC-bpa solid coordination frameworks (PDC=2,5-pyrindinedicarboxylate; bpa=1,2-DI(4-pyridil)ethane)): 2D and 3D structural flexibility producing a 3-c herringbone array next to ideal

    NASA Astrophysics Data System (ADS)

    Llano-Tomé, Francisco; Bazán, Begoña; Urtiaga, Miren-Karmele; Barandika, Gotzone; Antonia Señarís-Rodríguez, M.; Sánchez-Andújar, Manuel; Arriortua, María-Isabel

    2015-10-01

    Combination of polycarboxylate anions and dipyridyl ligands is an effective strategy to produce solid coordination frameworks (SCF) which are crystalline materials based on connections between metal ions through organic ligands. In this context, this work is focused on two novel CuII-based SCFs exhibiting PDC (2,5-pyridinedicarboxylate) and bpa (1,2-di(4-pyridyl)ethane), being the first structures reported in literature containing both ligands. Chemical formula are [Cu2[(PDC)2(bpa)(H2O)2]·3H2O·DMF (1), and [Cu2(PDC)2(bpa)(H2O)2]·7H2O (2), where DMF is dimethylformamide. Compounds 1 and 2 have been characterized by means of X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric (TG) analysis, differential thermal analysis (DTA) and dielectric measurements. The crystallographic analysis revealed that compounds 1 and 2 can be described as herringbone-type layers formed by helicoidal Cu-PDC-Cu chains connected through bpa ligands. Solvent molecules are crystallized between the layers, providing the inter-layer connections through hydrogen bonds. Differences between both compounds are attributable to the flexibility of bpa (in 2D) as well as to the 3D packing of the layers which is solvent dependent. This fact results in the fact that compound 2 is the most regular 3-c herringbone array reported so far. The structural dynamism of these networks is responsible for the crystalline to-amorphous to-crystalline (CAC) transformation from compound 1 to compound 2. Crystallochemical features for both compounds have also been studied and compared to similar 3-connected herringbone-arrays.

  6. Evidence for Steric Regulation of Fibrinogen Binding to Staphylococcus aureus Fibronectin-binding Protein A (FnBPA)*

    PubMed Central

    Stemberk, Vaclav; Jones, Richard P. O.; Moroz, Olga; Atkin, Kate E.; Edwards, Andrew M.; Turkenburg, Johan P.; Leech, Andrew P.; Massey, Ruth C.; Potts, Jennifer R.

    2014-01-01

    The adjacent fibrinogen (Fg)- and fibronectin (Fn)-binding sites on Fn-binding protein A (FnBPA), a cell surface protein from Staphylococcus aureus, are implicated in the initiation and persistence of infection. FnBPA contains a single Fg-binding site (that also binds elastin) and multiple Fn-binding sites. Here, we solved the structure of the N2N3 domains containing the Fg-binding site of FnBPA in the apo form and in complex with a Fg peptide. The Fg binding mechanism is similar to that of homologous bacterial proteins but without the requirement for “latch” strand residues. We show that the Fg-binding sites and the most N-terminal Fn-binding sites are nonoverlapping but in close proximity. Although Fg and a subdomain of Fn can form a ternary complex on an FnBPA protein construct containing a Fg-binding site and single Fn-binding site, binding of intact Fn appears to inhibit Fg binding, suggesting steric regulation. Given the concentrations of Fn and Fg in the plasma, this mechanism might result in targeting of S. aureus to fibrin-rich thrombi or elastin-rich tissues. PMID:24627488

  7. 49 CFR 385.15 - Administrative review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Administrative review. 385.15 Section 385.15... General § 385.15 Administrative review. (a) A motor carrier may request the FMCSA to conduct an administrative review if it believes FMCSA has committed an error in assigning its proposed safety rating...

  8. 49 CFR 385.15 - Administrative review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Administrative review. 385.15 Section 385.15... General § 385.15 Administrative review. (a) A motor carrier may request the FMCSA to conduct an administrative review if it believes FMCSA has committed an error in assigning its proposed safety rating...

  9. 29 CFR 1903.21 - State administration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false State administration. 1903.21 Section 1903.21 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.21 State administration. Nothing in this part 1903...

  10. 29 CFR 1903.21 - State administration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false State administration. 1903.21 Section 1903.21 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.21 State administration. Nothing in this part 1903...

  11. In utero and peripubertal exposure to phthalates and BPA in relation to female sexual maturation.

    PubMed

    Watkins, Deborah J; Téllez-Rojo, Martha Maria; Ferguson, Kelly K; Lee, Joyce M; Solano-Gonzalez, Maritsa; Blank-Goldenberg, Clara; Peterson, Karen E; Meeker, John D

    2014-10-01

    The age of pubertal onset for girls has declined over past decades. Research suggests that endocrine disrupting chemicals (EDCs) may play a role but exposure at multiple stages of development has not been considered. We examined in utero and peripubertal exposure to bisphenol-A (BPA) and phthalates in relation to serum hormones and sexual maturation among females in a Mexico City birth cohort. We measured phthalate metabolite and BPA concentrations in urine collected from mothers during their third trimester (n=116) and from their female children at ages 8-13 years (n=129). Among girls, we measured concurrent serum hormone concentrations, Tanner stages for breast and pubic hair development, and collected information on menarche onset. We used linear and logistic regression to model associations between in utero and peripubertal measures of exposure with hormones and sexual maturation, respectively, controlling for covariates. An interquartile range (IQR) increase in in utero urinary mono-2-ethylhexyl phthalate (MEHP) was positively associated with 29% (95% CI: 9.2-52.6%) higher dehydroepiandrosterone sulfate (DHEA-S), an early indicator of adrenarche, and 5.3 (95% CI: 1.13-24.9) times higher odds of a Tanner stage >1 for pubic hair development. Similar relationships were observed with other in utero but not peripubertal di-2-ethylhexyl phthalate (DEHP) metabolites. IQR increases in in utero monobenzyl phthalate (MBzP) and monoethyl phthalate (MEP) were associated with 29% and 25% higher serum testosterone concentrations (95% CI: 4.3-59.3; 2.1-54.1), respectively. In addition, we observed suggestive associations between in utero and peripubertal MEP concentrations and increased odds of having undergone menarche, and between peripubertal MnBP concentrations and increased odds of having a Tanner stage >1 for both breast and pubic hair development. BPA was not associated with in utero or peripubertal serum hormones or sexual maturation. Our findings suggest in utero

  12. 75 FR 78694 - Proposed Residential Exchange Program Settlement Agreement Proceeding (REP-12); Public Hearing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... governed by Sec. 1010 of BPA's Rules of Procedure Governing Rate Hearings, 51 FR 7611 (1986) (BPA Hearing... (BPA), Department of Energy (DOE). ACTION: Notice of Residential Exchange Program Settlement Agreement Proceeding (REP-12). SUMMARY: BPA is conducting the 2012 Residential Exchange Program Settlement...

  13. 2007-2008 Annual Progress Report for BPA Grant Exp Restore Walla Walla River Flow

    SciTech Connect

    Bower, Bob

    2009-07-10

    WWBWC and its partners have been working on a wide variety of conservation and aquifer recharge related activities including: monitoring groundwater and surface water conditions, creating a geospatial database for the Walla Walla River valley (project focal area), expanding aquifer recharge testing at the HBDIC site and conducting an extensive outreach/education program by which to share the information, ideas and potential solutions to our current water management issues in this basin. This report is an outline of those activities and is accompanied by individual program-component (attached as appendices) reports for the areas that BPA is assisting to fund these on-the-ground projects along with the innovative research and monitoring being done to further aquifer recharge as a water management tool for the Pacific Northwest.

  14. Sensitivity and selectivity determination of BPA in real water samples using PAMAM dendrimer and CoTe quantum dots modified glassy carbon electrode.

    PubMed

    Yin, Huanshun; Zhou, Yunlei; Ai, Shiyun; Chen, Quanpeng; Zhu, Xiangbin; Liu, Xianggang; Zhu, Lusheng

    2010-02-15

    Bisphenol A (BPA) is an environmental pollutant to disrupt endocrine system or cause cancer, thus the detection of BPA is very important. Herein, an amperometric sensor was fabricated based on immobilized CoTe quantum dots (CoTe QDs) and PAMAM dendrimer (PAMAM) onto glassy carbon electrode (GCE) surface. The cyclic voltammogram of BPA on the sensor exhibited a well-defined anodic peak at 0.490V in 0.1M pH 8.0 PBS. The determination conditions were optimized and the kinetic parameters were calculated. The linear range was 1.3 x 10(-8) to 9.89 x 10(-6)M with the correlation coefficient of 0.9999. The limit of detection was estimated to be 1 x 10(-9)M. The current reached the steady-state current within about 5s. Furthermore, the fabricated sensor was successfully applied to determine BPA in real water samples. PMID:19782469

  15. First-principles study for the adsorption of segments of BPA-PC on α-Al2O3(0001)

    NASA Astrophysics Data System (ADS)

    Blomqvist, Janne; Salo, Petri

    2011-10-01

    We have studied the adsorption of bisphenol-A-polycarbonate (BPA-PC) on the α-Al2O3(0001) surface using density functional theory (DFT) with van der Waals (vdW) corrections. The BPA-PC polymer can be divided into its chemical fragments, which are phenylene, carbonate, and isopropylidene groups. We have calculated the adsorption energy and geometry of the BPA-PC segments that consist of two to three adjacent groups of the polymer. Our DFT results show that the adsorption is dominated by the vdW interaction. It is also important to include the interaction of nearest-neighbor groups in order to provide a realistic environment for the adsorption of the polymer onto the surface. Our results also show that the BPA-PC molecule attaches to the alumina surface via the carbonate group located in the middle of the molecule chain.

  16. Developmental Bisphenol A (BPA) Exposure Leads to Sex-specific Modification of Hepatic Gene Expression and Epigenome at Birth that May Exacerbate High-fat Diet-induced Hepatic Steatosis

    PubMed Central

    Strakovsky, Rita S.; Wang, Huan; Engeseth, Nicki J.; Flaws, Jodi A.; Helferich, William G.; Pan, Yuan-Xiang; Lezmi, Stéphane

    2015-01-01

    Developmental bisphenol A (BPA) exposure increases adulthood hepatic steatosis with reduced mitochondrial function. To investigate potential epigenetic mechanisms behind developmental BPA-induced hepatic steatosis, pregnant Sprague-Dawley rats were dosed with vehicle (oil) or BPA (100 μg/kg/day) from gestational day 6 until postnatal day (PND) 21. After weaning, offspring were either challenged with a high-fat (HF; 45% fat) or remained on a control (C) diet until PND110. From PND60 to 90, both BPA and HF diet increased the fat/lean ratio in males only, and the combination of BPA and HF diet appeared to cause the highest ratio. On PND110, Oil-HF, BPA-C, and BPA-HF males had higher hepatic lipid accumulation than Oil-C, with microvesicular steatosis being marked in the BPA-HF group. Furthermore, on PND1, BPA increased and modified hepatic triglycerides (TG) and free fatty acid (FFA) composition in males only. In PND1 males, BPA increased hepatic expression of FFA uptake gene Fat/Cd36, and decreased the expression of TG synthesis- and β-oxidation-related genes (Dgat, Agpat6, Cebpα, Cebpβ, Pck1, Acox1, Cpt1a, Cybb). BPA altered DNA methylation, histone marks (H3Ac, H4Ac, H3Me2K4, H3Me3K36), and decreased the binding of several transcription factors (Pol II, C/EBPβ, SREBP1) within the male Cpt1a gene, the key β-oxidation enzyme. In PND1 females, BPA only increased the expression of genes involved in FFA uptake and TG synthesis (Lpl, Fasn, and Dgat). These data suggest that developmental BPA exposure alters and reprograms hepatic β-oxidation capacity in males, potentially thorough the epigenetic regulation of genes, and further alters the response to a HF diet. PMID:25748669

  17. Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis.

    PubMed

    Strakovsky, Rita S; Wang, Huan; Engeseth, Nicki J; Flaws, Jodi A; Helferich, William G; Pan, Yuan-Xiang; Lezmi, Stéphane

    2015-04-15

    Developmental bisphenol A (BPA) exposure increases adulthood hepatic steatosis with reduced mitochondrial function. To investigate the potential epigenetic mechanisms behind developmental BPA-induced hepatic steatosis, pregnant Sprague-Dawley rats were dosed with vehicle (oil) or BPA (100μg/kg/day) from gestational day 6 until postnatal day (PND) 21. After weaning, offspring were either challenged with a high-fat (HF; 45% fat) or remained on a control (C) diet until PND110. From PND60 to 90, both BPA and HF diet increased the fat/lean ratio in males only, and the combination of BPA and HF diet appeared to cause the highest ratio. On PND110, Oil-HF, BPA-C, and BPA-HF males had higher hepatic lipid accumulation than Oil-C, with microvesicular steatosis being marked in the BPA-HF group. Furthermore, on PND1, BPA increased and modified hepatic triglyceride (TG) and free fatty acid (FFA) compositions in males only. In PND1 males, BPA increased hepatic expression of FFA uptake gene Fat/Cd36, and decreased the expression of TG synthesis- and β-oxidation-related genes (Dgat, Agpat6, Cebpα, Cebpβ, Pck1, Acox1, Cpt1a, Cybb). BPA altered DNA methylation and histone marks (H3Ac, H4Ac, H3Me2K4, H3Me3K36), and decreased the binding of several transcription factors (Pol II, C/EBPβ, SREBP1) within the male Cpt1a gene, the key β-oxidation enzyme. In PND1 females, BPA only increased the expression of genes involved in FFA uptake and TG synthesis (Lpl, Fasn, and Dgat). These data suggest that developmental BPA exposure alters and reprograms hepatic β-oxidation capacity in males, potentially through the epigenetic regulation of genes, and further alters the response to a HF diet. PMID:25748669

  18. Gore proposes green strategy

    SciTech Connect

    1995-04-26

    A national environmental technology strategy laying out incentives for developing and using {open_quotes}green{close_quotes} technology was announced last week by Vice President Al Gore. The plan proposes a national goal of cutting waste 40%-50% and using 20%-25% less materials/unit of gross domestic product by Earth Day 2020. To meet that goal, the federal government aims to streamline environmental permitting, provide federal sites where US firms can test and demonstrate new technologies, create flexible regulation that encourages efficient and effective technologies, encourage research on pollution prevention, and improve monitoring data and information systems. The Administration says environmental technology is providing job growth twice that of the economy as a whole, and global markets are expected to rise from $300 billion to $500 billion by 2000. It adds that the US is the world market leader but only by a slim- and slipping-margin. Whereas previous federal support for environmental technologies focused on the front end of R&D and prototyping, the new strategy aims to bring technologies to market and encourage exports, according to the Administration`s National Commission for Employment Policy, which issued two reports last week. The commission says federal environmental policies now produce 68,000-80,000 jobs and contribute $3.5 billion-$3.7 billion to the economy.

  19. Urinary BPA measurements in children and mothers from six European member states: Overall results and determinants of exposure.

    PubMed

    Covaci, Adrian; Den Hond, Elly; Geens, Tinne; Govarts, Eva; Koppen, Gudrun; Frederiksen, Hanne; Knudsen, Lisbeth E; Mørck, Thit A; Gutleb, Arno C; Guignard, Cedric; Cocco, Emanuelle; Horvat, Milena; Heath, Ester; Kosjek, Tina; Mazej, Darja; Tratnik, Janja Snoj; Castaño, Argelia; Esteban, Marta; Cutanda, Francisco; Ramos, Juan José; Berglund, Marika; Larsson, Kristin; Jönsson, Bo A G; Biot, Pierre; Casteleyn, Ludwine; Joas, Reinhard; Joas, Anke; Bloemen, Louis; Sepai, Ovnair; Exley, Karen; Schoeters, Greet; Angerer, Jürgen; Kolossa-Gehring, Marike; Fiddicke, Ulrike; Aerts, Dominique; Koch, Holger M

    2015-08-01

    For the first time in Europe, both European-wide and country-specific levels of urinary Bisphenol A (BPA) were obtained through a harmonized protocol for participant recruitment, sampling and quality controlled biomarker analysis in the frame of the twin projects COPHES and DEMOCOPHES. 674 child-mother pairs were recruited through schools or population registers from six European member states (Belgium, Denmark, Luxembourg, Slovenia, Spain and Sweden). Children (5-12 y) and mothers donated a urine sample. Information on socio-demographic characteristics, life style, dietary habits, and educational level of the parents was provided by mothers. After exclusion of urine samples with creatinine values below 300 mg/L or above 3000 mg/L, 653 children and 639 mothers remained for which BPA was measured. The geometric mean (with 95% confidence intervals) and 90th percentile were calculated for BPA separately in children and in mothers and were named "European reference values". After adjustment for confounders (age and creatinine), average exposure values in each country were compared with the mean of the "European reference values" by means of a weighted analysis of variance. Overall geometric means of all countries (95% CI) adjusted for urinary creatinine, age and gender were 2.04 (1.87-2.24) µg/L and 1.88 (1.71-2.07) µg/L for children (n=653) and mothers (n=639), respectively. Multiple regression analysis was used to identify significant environmental, geographical, personal or life style related determinants. Consumption of canned food and social class (represented by the highest educational level of the family) were the most important predictors for the urinary levels of BPA in mothers and children. The individual BPA levels in children were significantly correlated with the levels in their mothers (r=0.265, p<0.001), which may suggest a possible common environmental/dietary factor that influences the biomarker level in each pair. Exposure of the general European

  20. Senior Administrators Should Have Administrative Contracts.

    ERIC Educational Resources Information Center

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  1. Novice Administrators: Personality and Administrative Style Changes.

    ERIC Educational Resources Information Center

    Schmidt, Linda J.; Kosmoski, Georgia J.; Pollack, Dennis R.

    Since the advent of effective-schools research findings, educational administration experts have advocated a democratic and collegial leadership style for school administrators. This paper provides the findings of a study that examined 43 beginning administrators (25 females, 32 Caucasians, 9 African-Americans, 2 Hispanics) to determine what…

  2. Transforming Administration in Academic Libraries.

    ERIC Educational Resources Information Center

    Honea, Sion M.

    1997-01-01

    Examines the traditional hierarchical administrative structure in academic libraries. Also analyzes some of its features, and questions specific principles of management in order to propose a more balanced organizational type based on organizational behavior and leadership that will best enable academic libraries to meet challenges. (PEN)

  3. 78 FR 18976 - Proposed Rate Extension and Opportunities for Public Review and Comment for the Cumberland System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... Southeastern Power Administration Proposed Rate Extension and Opportunities for Public Review and Comment for the Cumberland System AGENCY: Southeastern Power Administration, DOE. ACTION: Notice of proposed rate extension. SUMMARY: Southeastern Power Administration (Southeastern) proposes to extend the...

  4. Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats

    PubMed Central

    Mohamad Zaid, Siti Sarah; Kassim, Normadiah M.; Othman, Shatrah

    2015-01-01

    Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that can disrupt the normal functions of the reproductive system. The objective of the study is to investigate the potential protective effects of Tualang honey against BPA-induced uterine toxicity in pubertal rats. The rats were administered with BPA by oral gavage over a period of six weeks. Uterine toxicity in BPA-exposed rats was determined by the degree of the morphological abnormalities, increased lipid peroxidation, and dysregulated expression and distribution of ERα, ERβ, and C3 as compared to the control rats. Concurrent treatment of rats with BPA and Tualang honey significantly improved the uterine morphological abnormalities, reduced lipid peroxidation, and normalized ERα, ERβ, and C3 expressions and distribution. There were no abnormal changes observed in rats treated with Tualang honey alone, comparable with the control rats. In conclusion, Tualang honey has potential roles in protecting the uterus from BPA-induced toxicity, possibly accounted for by its phytochemical properties. PMID:26788107

  5. Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis

    SciTech Connect

    Strakovsky, Rita S.; Wang, Huan; Engeseth, Nicki J.; Flaws, Jodi A.; Helferich, William G.; Pan, Yuan-Xiang; Lezmi, Stéphane

    2015-04-15

    Developmental bisphenol A (BPA) exposure increases adulthood hepatic steatosis with reduced mitochondrial function. To investigate the potential epigenetic mechanisms behind developmental BPA-induced hepatic steatosis, pregnant Sprague–Dawley rats were dosed with vehicle (oil) or BPA (100 μg/kg/day) from gestational day 6 until postnatal day (PND) 21. After weaning, offspring were either challenged with a high-fat (HF; 45% fat) or remained on a control (C) diet until PND110. From PND60 to 90, both BPA and HF diet increased the fat/lean ratio in males only, and the combination of BPA and HF diet appeared to cause the highest ratio. On PND110, Oil-HF, BPA-C, and BPA-HF males had higher hepatic lipid accumulation than Oil-C, with microvesicular steatosis being marked in the BPA-HF group. Furthermore, on PND1, BPA increased and modified hepatic triglyceride (TG) and free fatty acid (FFA) compositions in males only. In PND1 males, BPA increased hepatic expression of FFA uptake gene Fat/Cd36, and decreased the expression of TG synthesis- and β-oxidation-related genes (Dgat, Agpat6, Cebpα, Cebpβ, Pck1, Acox1, Cpt1a, Cybb). BPA altered DNA methylation and histone marks (H3Ac, H4Ac, H3Me2K4, H3Me3K36), and decreased the binding of several transcription factors (Pol II, C/EBPβ, SREBP1) within the male Cpt1a gene, the key β-oxidation enzyme. In PND1 females, BPA only increased the expression of genes involved in FFA uptake and TG synthesis (Lpl, Fasn, and Dgat). These data suggest that developmental BPA exposure alters and reprograms hepatic β-oxidation capacity in males, potentially through the epigenetic regulation of genes, and further alters the response to a HF diet. - Highlights: • Developmental BPA exposure exacerbates HF-diet induced steatosis in adult males. • Gestational BPA exposure increases hepatic lipid accumulation in neonatal males. • BPA decreases Cpt1a and other hepatic β-oxidation genes in neonatal males. • BPA alters neonatal male Cpt1a

  6. Positron emission tomography and [18F]BPA: a perspective application to assess tumour extraction of boron in BNCT.

    PubMed

    Menichetti, L; Cionini, L; Sauerwein, W A; Altieri, S; Solin, O; Minn, H; Salvadori, P A

    2009-07-01

    Positron emission tomography (PET) has become a key imaging tool in clinical practice and biomedical research to quantify and study biochemical processes in vivo. Physiologically active compounds are tagged with positron emitters (e.g. (18)F, (11)C, (124)I) while maintaining their biological properties, and are administered intravenously in tracer amounts (10(-9)-10(-12)M quantities). The recent physical integration of PET and computed tomography (CT) in hybrid PET/CT scanners allows a combined anatomical and functional imaging: nowadays PET molecular imaging is emerging as powerful pharmacological tool in oncology, neurology and for treatment planning as guidance for radiation therapy. The in vivo pharmacokinetics of boron carrier for BNCT and the quantification of (10)B in living tissue were performed by PET in the late nineties using compartmental models based on PET data. Nowadays PET and PET/CT have been used to address the issue of pharmacokinetic, metabolism and accumulation of BPA in target tissue. The added value of the use of L-[(18)F]FBPA and PET/CT in BNCT is to provide key data on the tumour extraction of (10)B-BPA versus normal tissue and to predict the efficacy of the treatment based on a single-study patient analysis. Due to the complexity of a binary treatment like BNCT, the role of PET/CT is currently to design new criteria for patient enrolment in treatment protocols: the L-[(18)F]BPA/PET methodology could be considered as an important tool in newly designed clinical trials to better estimate the concentration ratio of BPA in the tumour as compared to neighbouring normal tissues. Based on these values for individual patients the decision could be made whether BNCT treatment could be advantageous due to a selective accumulation of BPA in an individual tumour. This approach, applicable in different tumour entities like melanoma, glioblastoma and head and neck malignancies, make this methodology as reliable prognostic and therapeutic indicator for

  7. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  8. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  9. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  10. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  11. 78 FR 47047 - Proposed Policy for Discontinuance of Certain Instrument Approach Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... network (MON) initiative. Proposed Policy The NDB and VOR IAPs recommended for cancellation would be... Federal Aviation Administration Proposed Policy for Discontinuance of Certain Instrument Approach Procedures AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed policy and...

  12. 75 FR 56137 - Controlled Substances: Proposed Aggregate Production Quotas for 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... Enforcement Administration Controlled Substances: Proposed Aggregate Production Quotas for 2011 AGENCY: Drug Enforcement Administration (DEA), Justice. ACTION: Notice of proposed year 2011 aggregate production quotas. SUMMARY: This notice proposes initial year 2011 aggregate production quotas for controlled substances...

  13. Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk.

    PubMed

    Fischer, Catha; Mamillapalli, Ramanaiah; Goetz, Laura G; Jorgenson, Elisa; Ilagan, Ysabel; Taylor, Hugh S

    2016-08-01

    Bisphenol-A (BPA) is a ubiquitous estrogen-like endocrine disrupting compound (EDC). BPA exposure in utero has been linked to breast cancer and abnormal mammary gland development in mice. The recent rise in incidence of human breast cancer and decreased age of first detection suggests a possible environmental etiology. We hypothesized that developmental programming of carcinogenesis may involve an aberrant immune response. Both innate and adaptive immunity play a role in tumor suppression through cytolytic CD8, NK, and Th1 T-cells. We hypothesized that BPA exposure in utero would lead to dysregulation of both innate and adaptive immunity in the mammary gland. CD1 mice were exposed to BPA in utero during gestation (days 9-21) via osmotic minipump. At 6 weeks, the female offspring were ovariectomized and estradiol was given at 8 weeks. RNA and protein were extracted from the posterior mammary glands, and the mRNA and protein levels were measured by PCR array, qRT-PCR, and western blot. In mouse mammary tissue, BPA exposure in utero significantly decreased the expression of members of the chemokine CXC family (Cxcl2, Cxcl4, Cxcl14, and Ccl20), interleukin 1 (Il1) gene family (Il1β and Il1rn), interleukin 2 gene family (Il7 receptor), and interferon gene family (interferon regulatory factor 9 (Irf9), as well as immune response gene 1 (Irg1). Additionally, BPA exposure in utero decreased Esr1 receptor gene expression and increased Esr2 receptor gene expression. In utero exposure of BPA resulted in significant changes to inflammatory modulators within mammary tissue. We suggest that dysregulation of inflammatory cytokines, both pro-inflammatory and anti-inflammatory, leads to a microenvironment that may promote disordered cell growth through inhibition of the immune response that targets cancer cells. PMID:26911702

  14. Long-term effects of a binary mixture of perfluorooctane sulfonate (PFOS) and bisphenol A (BPA) in zebrafish (Danio rerio).

    PubMed

    Keiter, Su; Baumann, L; Färber, H; Holbech, H; Skutlarek, D; Engwall, M; Braunbeck, T

    2012-08-15

    Previous in vitro studies have reported the potential of perfluorooctane sulfonate (PFOS) to increase the toxicity of other compounds. Given the complex nature of mixtures of environmental pollutants in aquatic systems together with the persistent and bioaccumulative properties of PFOS, this study aimed at evaluating the long-term effects and toxicity-increasing behavior of PFOS in vivo using the zebrafish (Danio rerio). Fish were maintained in flow-through conditions and exposed to single and binary mixtures of PFOS and the endocrine disruptor bisphenol A (BPA) at nominal concentrations of 0.6, 100 and 300 μg/L and 10, 200 and 400 μg/L, respectively. F1 and F2 generations were evaluated from 0 to 180 days post-fertilization (dpf) and F3 generation was evaluated from 0 to 14 dpf. Survival was documented in all generations, whereas growth, fecundity, fertilization rate, histological alterations (in liver, thyroid and gonads) and vitellogenin (Vtg) induction in males were evaluated for F1 and F2 generations. Data for growth were collected at 30, 90 and 180 dpf and data for histological evaluations and Vtg induction were analyzed at 90 and 180 dpf. No significant effects on survival were seen in the F1 generation in any treatment following 180 d exposure; however, in the F2 generation, 300 μg/L PFOS both alone and in combination with BPA (10, 200 and 400 μg/L) induced 100% mortality within 14 dpf. PFOS (0.6 and 300 μg/L) did not increase the Vtg-inducing potential of BPA (10, 200 and 400 μg/L) in a binary mixture. In contrast, binary mixtures with 300 μg/L PFOS suppressed the Vtg levels in F1 males at 90 dpf when compared to single BPA exposures. Whereas the lowest tested PFOS concentration (0.6 μg/L) showed an estrogenic potential in terms of significant Vtg induction, Vtg levels were generally found to decrease with increasing PFOS-exposure in both F1 and F2 generations. In F1 generation, BPA-exposure was found to increase Vtg levels in a concentration

  15. Organization/Administration.

    ERIC Educational Resources Information Center

    Chaffee, Ellen Earle

    Patterns that emerged from reviewing 26 syllabi for courses on organization and administration in higher education are discussed, and six sample syllabi are presented. The syllabi focused more on organization than administration. Of the 26 syllabi, 19 dealt with organization and administration generally; 5 with administration in a specific…

  16. 76 FR 2142 - Employee Benefits Security Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Administration (EBSA) published in the Federal Register on October 22, 2010, (75 FR 65263), a proposed rule under... on October 22, 2010 (75 FR 65263), is being extended until February 3, 2011. To facilitate the... Benefits Security Administration Hearing on Definition of ``Fiduciary'' AGENCY: Employee Benefits...

  17. Issues and Ideas: Organization, Administration and Supervision.

    ERIC Educational Resources Information Center

    Miller, Irving

    1982-01-01

    This article discusses the basic characteristics of organization, administration, supervision, and specific problems of human service organizations and relates them to the concept of power. The author proposes an integration of the two models of supervision so that the administrative and teaching functions will both be served. (Author)

  18. 28 CFR 68.52 - Final order of the Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Final order of the Administrative Law... FRAUD § 68.52 Final order of the Administrative Law Judge. (a) Proposed final order. (1) Within twenty... Administrative Law Judge may, by order, require that when a proposed order is filed for the Administrative...

  19. 77 FR 40627 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency... Administrator for Mitigation, Department of Homeland Security, Federal Emergency Management Agency. BILLING CODE... Development Building, 25 Dorrance Street, Providence, RI 02903. Big Horn County, Wyoming, and...

  20. 28 CFR 61.7 - Legislative proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... compliance with 40 CFR 1506.8. ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.7 Legislative proposals. (a) Each subunit of...

  1. 28 CFR 61.7 - Legislative proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... compliance with 40 CFR 1506.8. ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.7 Legislative proposals. (a) Each subunit of...

  2. 28 CFR 61.7 - Legislative proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... compliance with 40 CFR 1506.8. ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.7 Legislative proposals. (a) Each subunit of...

  3. 28 CFR 61.7 - Legislative proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... compliance with 40 CFR 1506.8. ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.7 Legislative proposals. (a) Each subunit of...

  4. 28 CFR 61.7 - Legislative proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... compliance with 40 CFR 1506.8. ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.7 Legislative proposals. (a) Each subunit of...

  5. 75 FR 41165 - Proposed Agency Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... Administrator of the Environmental Protection Agency (EPA) assessing whether the renewable fuel standard (RFS... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Proposed Agency Information Collection AGENCY: Department of Energy. ACTION: Notice and request for...

  6. Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration.

    PubMed

    Waidyanatha, Suramya; Mathews, James M; Patel, Purvi R; Black, Sherry R; Snyder, Rodney W; Fennell, Timothy R

    2015-01-01

    1. Bisphenol AF (BPAF) is used as a crosslinking agent for polymers and is being considered as a replacement for bisphenol A (BPA). 2. In this study, comparative clearance and metabolism of BPAF and BPA in hepatocytes and the disposition and metabolism of BPAF in rodents following oral administration of 3.4, 34 or 340 mg/kg [(14)C]BPAF were investigated. 3. BPAF was cleared more slowly than BPA in hepatocytes with the rate: rat > mouse > human. 4. [(14)C]BPAF was excreted primarily in feces by 72 h after oral administration to rats (65-80%) and mice (63-72%). Females excreted more in urine (rat, 15%; mouse, 24%) than males (rat, 1-4%; mouse, 10%). Residual tissue radioactivity was <2% of the dose at 72 h. Similar results were observed following intravenous administration. 5. In male rats, 52% of a 340 mg/kg oral dose was excreted in 24 h bile and was mostly comprised of BPAF glucuronide. However, >94% of fecal radioactivity was present as BPAF, suggesting extensive deconjugation in the intestine. 6. Metabolites identified in bile were BPAF-glucuronide, -diglucuronide, -glucuronide sulfate and -sulfate. 7. In conclusion, BPAF was well absorbed following gavage administration and highly metabolized and excreted mostly in the feces as BPAF. PMID:25923777

  7. 78 FR 61367 - Health Resources and Services Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Agency Information Collection Activities; Proposed Collection; Public Comment Request AGENCY: Health Resources and Services Administration,...

  8. 76 FR 49763 - Bonneville Power Administration; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Bonneville Power Administration; Notice of Filing Take notice that on August 1, 2011, the Bonneville Power Administration submitted its Proposed 2012 Wholesale Power...

  9. Expression of stress response HSP70 gene in Asian paddle crabs, Charybdis japonica, exposure to endocrine disrupting chemicals, bisphenol A (BPA) and 4-nonylphenol (NP)

    NASA Astrophysics Data System (ADS)

    Park, Kiyun; Kwak, Ihn-Sil

    2013-06-01

    The Asian paddle crab, Charybdis japonica, is a potential bio-indicator reflecting marine sediment toxicity as well as a commercially important species living along coastal areas in Korea. This study investigated its stress response by looking at the heat shock protein (HSP70) gene of C. japonica when the organism is exposed to bisphenol A (BPA) and 4-nonylphenol (NP). We characterized partial sequence of HSP70 as the stressresponse gene of C. japonica. The nucleotide sequence of C. japonica HSP70 is over 90% homologous with the corresponding gene of other crabs. Phylogenetic tree analysis revealed a close relationship between C. japonica HSP70 and HSP70 in other species of lobster and shrimps. HSP70 mRNA transcripts were detected in all the examined tissues of C. japonica, with the highest level in gills, the organ that most frequently came into contact with the external BPA or NP-laden water. As no reference data were available for C. japonica crab exposure, the BPA and NP 24-h LC50 values have not been previously determined. The expression of the C. japonica HSP70 gene to various BPA or NP concentrations during short and longer times was assessed. Gene expression was significantly induced in concentration- and time-dependent manners after BPA or NP exposures. These results support the postulation that crab C. japonica HSP70 could be a potential stress response molecular marker to monitor marine ecosystems.

  10. 76 FR 74838 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA... soliciting comments on the accuracy of the agency's burden estimate; the need for the information;...

  11. 77 FR 70165 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... through the use of automated collection techniques or other forms of information technology. Consideration... forwarded by writing to the Administration for Children and Families, Office of Planning, Research and... HUMAN SERVICES Administration for Children and Families Proposed Information Collection...

  12. 78 FR 26051 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... be forwarded by writing to the Administration for Children and Families, Office of Planning, Research... technology. Consideration will be given to comments and suggestions submitted within 60 days of this... HUMAN SERVICES Administration for Children and Families Proposed Information Collection...

  13. 78 FR 16509 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... of automated collection techniques or other forms of information technology. Consideration will be... to the Administration for Children and Families, Office of Planning, Research and Evaluation, 370 L... HUMAN SERVICES Administration for Children and Families Proposed Information Collection...

  14. 78 FR 32666 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... be forwarded by writing to the Administration for Children and Families, Office of Planning, Research... technology. Consideration will be given to comments and suggestions submitted within 60 days of this... HUMAN SERVICES Administration for Children and Families Proposed Information Collection...

  15. 78 FR 26052 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... be forwarded by writing to the Administration for Children and Families, Office of Planning, Research... technology. Consideration will be given to comments and suggestions submitted within 60 days of this... HUMAN SERVICES Administration for Children and Families Proposed Information Collection...

  16. 28 CFR 512.12 - Content of research proposal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... required by 28 CFR part 46, if applicable. ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Content of research proposal. 512.12... ADMINISTRATION RESEARCH Research § 512.12 Content of research proposal. When submitting a research proposal,...

  17. 28 CFR 512.12 - Content of research proposal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... required by 28 CFR part 46, if applicable. ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Content of research proposal. 512.12... ADMINISTRATION RESEARCH Research § 512.12 Content of research proposal. When submitting a research proposal,...

  18. 28 CFR 68.52 - Final order of the Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administrative Law Judge may allow, the Administrative Law Judge may require the parties to file proposed... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Final order of the Administrative Law... AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE ADMINISTRATIVE LAW JUDGES IN CASES...

  19. Low Probability Tail Event Analysis and Mitigation in BPA Control Area: Task One Report

    SciTech Connect

    Lu, Shuai; Makarov, Yuri V.

    2009-04-01

    This is a report for task one of the tail event analysis project for BPA. Tail event refers to the situation in a power system when unfavorable forecast errors of load and wind are superposed onto fast load and wind ramps, or non-wind generators falling short of scheduled output, the imbalance between generation and load becomes very significant. This type of events occurs infrequently and appears on the tails of the distribution of system power imbalance; therefore, is referred to as tail events. This report analyzes what happened during the Electric Reliability Council of Texas (ERCOT) reliability event on February 26, 2008, which was widely reported because of the involvement of wind generation. The objective is to identify sources of the problem, solutions to it and potential improvements that can be made to the system. Lessons learned from the analysis include the following: (1) Large mismatch between generation and load can be caused by load forecast error, wind forecast error and generation scheduling control error on traditional generators, or a combination of all of the above; (2) The capability of system balancing resources should be evaluated both in capacity (MW) and in ramp rate (MW/min), and be procured accordingly to meet both requirements. The resources need to be able to cover a range corresponding to the variability of load and wind in the system, additional to other uncertainties; (3) Unexpected ramps caused by load and wind can both become the cause leading to serious issues; (4) A look-ahead tool evaluating system balancing requirement during real-time operations and comparing that with available system resources should be very helpful to system operators in predicting the forthcoming of similar events and planning ahead; and (5) Demand response (only load reduction in ERCOT event) can effectively reduce load-generation mismatch and terminate frequency deviation in an emergency situation.

  20. Fate of phthalates and BPA in agricultural and non-agricultural soils of the Paris area (France).

    PubMed

    Tran, Bich Chau; Teil, Marie-Jeanne; Blanchard, Martine; Alliot, Fabrice; Chevreuil, Marc

    2015-07-01

    This study (i) investigated the concentration levels of nine phthalates and bisphenol A (BPA) in sludge samples originating from a French wastewater treatment plant (WWTP), (ii) studied the distribution of target compounds according to soil depth and calculated their half-lives, and (iii) compared the contamination level of the agricultural soil with those of soils with other land uses. The sludge contamination levels varied from a few hundred nanograms per gram dry weight (dw) for diethyl phthalate (DEP), di-iso-butyl phthalate (DiBP), di-n-butyl phthalate (DnBP), and butyl-benzyl phthalate (BBP) to a few micrograms per gram dw for diethylhexyl phthalate (DEHP), di-iso-nonyl phthalate (DiNP), and di-iso-decyl phthalate (DiDP). After sludge application, an 8-fold increase for DEHP level and a 3-fold increase for BPA level occurred in the surface horizon of the soil. The mean distribution of phthalates according to the depth showed a positive gradient for the low molecular weight compounds and inversely, a negative gradient for the highest ones. The half-lives in the 0-20-cm soil horizon were 64 days for DEHP and 36 days for BPA. A predictive environmental concentration (PEC) of 0.3 μg g(-1) dw was estimated for DEHP, while the experimental value was 0.16 μg g(-1) dw, suggesting degradation processes in soil and/or formation of non-extractable residues. Comparisons of contamination levels for soils from different origins (urban, rural, agricultural, and forest) showed that the urban soil remained the most contaminated one, prior to the agricultural soil after treatment. PMID:25794574

  1. Administration for Community Living

    MedlinePlus

    ... by Acting Assistant Secretary for Aging and ACL Administrator Edwin Walker at the HCBS Conference (08/29/ ... Remarks by Assistant Secretary on Aging and ACL Administrator Kathy Greenlee at the n4a Answers on Aging ...

  2. The New Administrative Computing.

    ERIC Educational Resources Information Center

    Green, Kenneth C.

    1988-01-01

    The past decade has seen dramatic changes in administrative computing, including more systems, more applications, a new group of computer users, and new opportunities for computer use in campus administration. (Author/MSE)

  3. Transportation Security Administration

    MedlinePlus

    ... content Official website of the Department of Homeland Security Transportation Security Administration When I fly can I bring my... ... to know if you could bring through the security checkpoint. Main menu Administrator Travel Security Screening Special ...

  4. NASA, NOAA administrators nominated

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    President Ronald Reagan recently said he intended to nominate James Montgomery Beggs as NASA Administrator and John V. Byrne as NOAA Administrator. These two positions are key scientific posts that have been vacant since the start of the Reagan administration on January 20. The President also said he intends to nominate Hans Mark as NASA Deputy Administrator. At press time, Reagan had not designated his nominee for the director of the Office of Science and Technology Policy.

  5. A Philosophy of Administration.

    ERIC Educational Resources Information Center

    Bruening, William H.

    Justification is given for paying relatively large salaries to college administrators, specifically the president or chancellor and the chief academic officer. Three administrative task areas are discussed as criteria: management, administration per se, and leadership. It is contended that only leadership can be used as a criterion for…

  6. School Business Administration.

    ERIC Educational Resources Information Center

    Jordan, K. Forbis; And Others

    This textbook reviews the principal concerns within each of 13 major responsibility areas in school business administration. The first chapter assesses the political, social, and economic context in which schools function and school administrators work. The role and function of the school business administrator within this context is addressed in…

  7. Administrative Support Is Essential to a Good Transportation Program.

    ERIC Educational Resources Information Center

    Button, Charles T.

    1984-01-01

    Discusses conditions preventing school bus drivers from maintaining discipline and safety and proposes administrative remedies. Gives examples of overlooked hazards in both riders' and drivers' behaviors. (MCG)

  8. Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID.

    PubMed

    Madhukar, Mamta; Sawraj, Shruti; Sharma, Pritam Dev

    2010-06-01

    A novel mutual prodrug consisting of 4-biphenylacetic acid (BPA) and quercetin tetramethyl ether (QTME) has been synthesized as a gastrosparing NSAID, devoid of ulcerogenic side effects. The physicochemical properties, including aqueous solubility, partition coefficient, chemical stability and enzymatic hydrolysis of synthesized derivative have been studied to assess its prodrug potential. Its antiinflammatory, antiulcer and analgesic activities were also evaluated. The results indicated that BPA-QTME derivative is chemically stable, biolabile and possesses optimum lipophilicity. The synthesized compound also exhibited retention of antiinflammatory activity with reduced ulcerogenicity. Based on these observations, the therapeutic potential of this mutual prodrug is discussed. PMID:20227799

  9. 76 FR 50225 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... is proposing an information collection activity as part of an evaluation of healthy marriage and... discussions will be held with administrators and managers of healthy marriage and responsible...

  10. 28 CFR 61.8 - Classified proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Classified proposals. 61.8 Section 61.8... ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.8 Classified proposals. If an environmental document includes classified matter, a version containing only unclassified material shall be prepared unless...

  11. 28 CFR 61.8 - Classified proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Classified proposals. 61.8 Section 61.8... ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.8 Classified proposals. If an environmental document includes classified matter, a version containing only unclassified material shall be prepared unless...

  12. 28 CFR 61.8 - Classified proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Classified proposals. 61.8 Section 61.8... ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.8 Classified proposals. If an environmental document includes classified matter, a version containing only unclassified material shall be prepared unless...

  13. 28 CFR 61.8 - Classified proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Classified proposals. 61.8 Section 61.8... ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.8 Classified proposals. If an environmental document includes classified matter, a version containing only unclassified material shall be prepared unless...

  14. 28 CFR 61.8 - Classified proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Classified proposals. 61.8 Section 61.8... ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.8 Classified proposals. If an environmental document includes classified matter, a version containing only unclassified material shall be prepared unless...

  15. 76 FR 67728 - Proposed Settlement Agreement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... Pollutants for Reciprocating Internal Combustion Engines (the RICE NESHAP), 75 FR 51570 (August 20, 2010... hydrocarbons and that, by March 14, 2013, the Administrator of EPA will sign a final action on this proposal... hydrocarbons. Under the terms of the proposed settlement agreement, EPA states that it anticipates that,...

  16. 29 CFR 1903.15 - Proposed penalties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Health Officer of the proposed penalty under section 17 of the Act, or that no penalty is being proposed... the Compliance Safety and Health Officer, the employer immediately abates, or initiates steps to...

  17. 14 CFR § 1260.10 - Proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's are described in 48 CFR part 1872. (2) An unsolicited proposal. (See § 1260.17.) (b) The proposal... Compliance with NASA Regulations Concerning Nondiscrimination as required by 14 CFR parts 1250 through...

  18. 14 CFR 1260.10 - Proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's are described in 48 CFR part 1872. (2) An unsolicited proposal. (See § 1260.17.) (b) The proposal... Compliance with NASA Regulations Concerning Nondiscrimination as required by 14 CFR parts 1250 through...

  19. 14 CFR 1260.10 - Proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's are described in 48 CFR part 1872. (2) An unsolicited proposal. (See § 1260.17.) (b) The proposal... Compliance with NASA Regulations Concerning Nondiscrimination as required by 14 CFR parts 1250 through...

  20. 14 CFR 1260.10 - Proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's are described in 48 CFR part 1872. (2) An unsolicited proposal. (See § 1260.17.) (b) The proposal... Compliance with NASA Regulations Concerning Nondiscrimination as required by 14 CFR parts 1250 through...

  1. 14 CFR 1260.10 - Proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrator for Procurement (HS). NRA's are described in the NASA FAR Supplement (NFS) 48 CFR 1835.016. AO's are described in 48 CFR part 1872. (2) An unsolicited proposal. (See § 1260.17.) (b) The proposal... Compliance with NASA Regulations Concerning Nondiscrimination as required by 14 CFR parts 1250 through...

  2. 77 FR 39654 - Proposed Legal Interpretation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... proposed legal interpretation published at 77 FR 32441 will be moved to the correct docket, FAA-2012- 0670... Administration (FAA), DOT. ACTION: Proposed interpretation; correction. SUMMARY: On June 1, 2012 at 77 FR 32441...: 202-267- 3073. Correction In the Federal Register of June 1, 2012, in FR Doc. 2012-13290, on...

  3. 29 CFR 1903.15 - Proposed penalties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Health Officer of the proposed penalty under section 17 of the Act, or that no penalty is being proposed... the Compliance Safety and Health Officer, the employer immediately abates, or initiates steps to...

  4. 75 FR 39241 - Hooper Springs Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... Bonneville Power Administration Hooper Springs Project AGENCY: Bonneville Power Administration (BPA... Hooper Springs Project). The new BPA substation would be called Hooper Springs Substation and would be... 115-kV Lane Creek Substation, east of the City of Wayan, Idaho. The proposed project would...

  5. Surface aspects of discolouration in Bisphenol A Polycarbonate (BPA-PC), used as lens in LED-based products

    NASA Astrophysics Data System (ADS)

    Yazdan Mehr, M.; van Driel, W. D.; Udono, H.; Zhang, G. Q.

    2014-11-01

    The surface-related reactions during discolouration of Bisphenol A Polycarbonate (BPA-PC), used as LED lens plates, under thermal stress are studied. X-ray photoelectron spectroscopy (XPS) has been used to monitor the changes in the surface chemistry of BPA-PC plates over a temperature range of 100-140 °C for a period up to 3000 h. Increasing time under thermal stress is associated with the discolouration, and increase in the yellowing index (YI) of PC plastic lens. The XPS results show that discolouration is associated with oxidation at the surface, finding a significant increase in the signal ratio O1s/C1s in the XPS spectra of degraded specimens. During thermal ageing, the Csbnd H concentration decreases and new oxide features Cdbnd O and Osbnd Cdbnd O form, with the latter being a support for oxidation at the surface being a major reaction during discolouration. Results also show that irradiation with blue light during thermal ageing accelerates the kinetics of discolouration and the increased O1s/C1s ratio in XPS spectra.

  6. 75 FR 44163 - Antidumping and Countervailing Duty Proceedings: Electronic Filing Procedures; Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures AGENCY: Import Administration, International Trade Administration, Department of Commerce. ACTION: Proposed Rule; Request...

  7. NOAO observing proposal processing system

    NASA Astrophysics Data System (ADS)

    Bell, David J.; Gasson, David; Hartman, Mia

    2002-12-01

    Since going electronic in 1994, NOAO has continued to refine and enhance its observing proposal handling system. Virtually all related processes are now handled electronically. Members of the astronomical community can submit proposals through email, web form or via Gemini's downloadable Phase-I Tool. NOAO staff can use online interfaces for administrative tasks, technical reviews, telescope scheduling, and compilation of various statistics. In addition, all information relevant to the TAC process is made available online. The system, now known as ANDES, is designed as a thin-client architecture (web pages are now used for almost all database functions) built using open source tools (FreeBSD, Apache, MySQL, Perl, PHP) to process descriptively-marked (LaTeX, XML) proposal documents.

  8. 77 FR 63293 - Proposed Information Collection; Comment Request; Coastal Ocean Program Grants Proposal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Ocean Program Grants Proposal Application Package AGENCY: National Oceanic and Atmospheric... Atmospheric Administration's Coastal Ocean Program (COP) provides direct financial assistance through grants... authority for COP is Public Law 102-567 Section 201 (Coastal Ocean Program). In addition to...

  9. 77 FR 37412 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... legislation to the overall child support enforcement picture. This information will help policymakers... HUMAN SERVICES Administration for Children and Families Proposed Information Collection Activity... the information collection described above. Copies of the proposed collection of information can...

  10. 32 CFR 989.28 - Airspace and range proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Review. Airspace and range proposals require review by HQ USAF/XOO prior to public announcement and... attachment to the proposal sent to HQ USAF/XOO. (b) Federal Aviation Administration. The DoD and the...

  11. 32 CFR 989.28 - Airspace and range proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Review. Airspace and range proposals require review by HQ USAF/XOO prior to public announcement and... attachment to the proposal sent to HQ USAF/XOO. (b) Federal Aviation Administration. The DoD and the...

  12. 78 FR 42081 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed Information Collection Activity; Comment Request Proposed Projects Title: New Runaway and Homeless Youth Management Information...

  13. 77 FR 59626 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... HEALTH SERVICES ADMINISTRATION Agency Information Collection Activities: Proposed Collection; Comment Request The Substance Abuse and Mental Health Services Administration (SAMHSA) will publish periodic... Mental Health Services Administration (SAMSHA) is requesting approval to conduct in-person Site...

  14. 75 FR 8963 - Agency Information Collection Activities; Proposed Collection; Comment Request; Reporting and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed... Products for Manufacturers and Distributors of Electronic Products AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing an opportunity...

  15. 76 FR 2124 - Agency Information Collection Activities; Proposed Collection; Comment Request; Voluntary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed Collection; Comment Request; Voluntary National Retail Food Regulatory Program Standards AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is...

  16. 78 FR 31946 - Agency Information Collection Activities; Proposed Collection; Public Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... HUMAN SERVICES Health Resources and Services Administration Agency Information Collection Activities; Proposed Collection; Public Comment Request AGENCY: Health Resources and Services Administration, HHS... Health Resources and Services Administration (HRSA) announces plans to submit an Information...

  17. 78 FR 32392 - Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed... Biologics in Electronic Format AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing an opportunity for public comment on the...

  18. 75 FR 74059 - Agency Information Collection Activities: Proposed Collection; Comment Request; Radioactive Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities: Proposed Collection; Comment Request; Radioactive Drug Research Committees AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing an opportunity for...

  19. 76 FR 19976 - Proposed Information Collection; Comment Request; Survey of EDA Grant Process Improvement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... Economic Development Administration Proposed Information Collection; Comment Request; Survey of EDA Grant Process Improvement AGENCY: Economic Development Administration, Commerce. ACTION: Notice. SUMMARY: The... Services, Economic Development Administration, Department of Commerce, HCHB Room 7227, 1401...

  20. 76 FR 7148 - Proposed Information Collection; Comment Request; Revolving Loan Fund (RLF) Reporting and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-09

    ... Economic Development Administration Proposed Information Collection; Comment Request; Revolving Loan Fund (RLF) Reporting and Compliance Requirements AGENCY: Economic Development Administration. ACTION: Notice... Services, Economic Development Administration, Department of Commerce, HCHB Room 7227, 1401...

  1. 77 FR 19178 - Proposed Information Collection; Comment Request; Comprehensive Economic Development Strategy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Economic Development Administration Proposed Information Collection; Comment Request; Comprehensive Economic Development Strategy AGENCY: Economic Development Administration (EDA), Department of Commerce... Analyst, Office of Regional Affairs, Room 7009, Economic Development Administration, Washington, DC...

  2. 78 FR 8105 - Proposed Information Collection; Comment Request; Application for Investment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... Economic Development Administration Proposed Information Collection; Comment Request; Application for Investment Assistance AGENCY: Economic Development Administration, Commerce. ACTION: Notice. SUMMARY: The... INFORMATION: I. Abstract The mission of the Economic Development Administration (EDA) is to lead the...

  3. 76 FR 14405 - Agency Information Collection Activities; Proposed Collection; Comment Request; Guidance for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed... Biologics AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug... Management (HFA- 305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852....

  4. 77 FR 20355 - Proposed Information Collection; Comment Request; Award Amendment Requests and Project Service Maps

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... Economic Development Administration Proposed Information Collection; Comment Request; Award Amendment Requests and Project Service Maps AGENCY: Economic Development Administration (EDA), Department of Commerce... Analyst, Office of Regional Affairs, Room 7009, Economic Development Administration, Washington, DC...

  5. 77 FR 20006 - Proposed Information Collection; Comment Request; Requirements for Approved Construction Investments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... Economic Development Administration Proposed Information Collection; Comment Request; Requirements for Approved Construction Investments AGENCY: Economic Development Administration (EDA), Department of Commerce... Analyst, Office of Regional Affairs, Room 7009, Economic Development Administration, Washington, DC...

  6. 78 FR 4153 - Agency Information Collection Activities; Proposed Collection; Comment Request; Food Labeling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed Collection; Comment Request; Food Labeling; Notification Procedures for Statements on Dietary Supplements AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration...

  7. 75 FR 11148 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... Information Administration Agency Information Collection Activities: Proposed Collection; Comment Request AGENCY: Energy Information Administration (EIA), Department of Energy (DOE). ACTION: Agency Information... Department of Energy, Energy Information Administration, Reserves and Production Division, 1999 Bryan...

  8. Klondike III/Biglow Canyon Wind Integration Project; Record of Decision, October 25, 2006.

    SciTech Connect

    United States. Bonneville Power Administration

    2006-10-25

    The Bonneville Power Administration (BPA) has decided to implement the Proposed Action identified in the Klondike III/Biglow Canyon Wind Integration Project Final Environmental Impact Statement (FEIS) (DOE/EIS-0374, September 2006). Under the Proposed Action, BPA will offer PPM Energy, Inc. (PPM) contract terms for interconnection of the proposed Klondike III Wind Project, located in Sherman County, Oregon, with the Federal Columbia River Transmission System (FCRTS). BPA will also offer Portland General Electric (PGE)1 contract terms for interconnection of its proposed Biglow Canyon Wind Farm, also located in Sherman County, Oregon, with the FCRTS, as proposed in the FEIS. To interconnect these wind projects, BPA will build and operate a 12-mile long, 230-kilovolt (kV) double-circuit transmission line between the wind projects and BPA's new 230-kV John Day Substation in Sherman County, Oregon. BPA will also expand its existing 500-kV John Day Substation.

  9. Veterans Administration Databases

    Cancer.gov

    The Veterans Administration Information Resource Center provides database and informatics experts, customer service, expert advice, information products, and web technology to VA researchers and others.

  10. 31 CFR 10.76 - Decision of Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Decision of Administrative Law Judge... Administrative Law Judge. (a) In general—(1) Hearings. Within 180 days after the conclusion of a hearing and the receipt of any proposed findings and conclusions timely submitted by the parties, the Administrative...

  11. 50 CFR 228.21 - Assistant Administrator's decision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Assistant Administrator's decision. 228.21... Assistant Administrator's decision. (a) Upon receipt of the recommended decision and transcript and after... Administrator shall make a final decision on the proposed regulations and waiver, where applicable....

  12. 50 CFR 228.21 - Assistant Administrator's decision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Assistant Administrator's decision. 228...) REGULATIONS § 228.21 Assistant Administrator's decision. (a) Upon receipt of the recommended decision and..., the Assistant Administrator shall make a final decision on the proposed regulations and waiver,...

  13. 50 CFR 228.21 - Assistant Administrator's decision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Assistant Administrator's decision. 228...) REGULATIONS § 228.21 Assistant Administrator's decision. (a) Upon receipt of the recommended decision and..., the Assistant Administrator shall make a final decision on the proposed regulations and waiver,...

  14. Bonneville Power Administration, Office of Engineering 10-Year Plan, 1992-2001 : Draft.

    SciTech Connect

    United States. Bonneville Power Administration. Office of Engineering.

    1992-05-01

    For over 50 years, the Bonneville Power Administration (BPA) has evolved to supply electric power to more than 170 customer utilities and direct service industries across 14,800 miles of high voltage transmission lines. BPA's Office of Engineering provides the planning, development, and engineering for the required expansion, upgrade, and replacement of the transmission system. The purpose of this 10-Year Plan is to present strategies to maintain a reliable energy delivery system within changing public, business, technological, and environmental climates. The issues and trends discussed in this document and our strategies for addressing them provide the background for the Office of Engineering programs and projects. With a budget in the hundreds of millions annually and increasing public concern, we welcome the opportunity to communicate with our customers. In addition to the factors, trends and issues described in this document are two appendices containing project costs and program and staffing levels. These figures are preliminary with estimates current as of May 13, 1992.

  15. Bonneville Power Administration, Office of Engineering 10-Year Plan, 1992-2001 : Draft.

    SciTech Connect

    United States. Bonneville Power Administration. Office of Engineering.

    1992-05-01

    For over 50 years, the Bonneville Power Administration (BPA) has evolved to supply electric power to more than 170 customer utilities and direct service industries across 14,800 miles of high voltage transmission lines. BPA`s Office of Engineering provides the planning, development, and engineering for the required expansion, upgrade, and replacement of the transmission system. The purpose of this 10-Year Plan is to present strategies to maintain a reliable energy delivery system within changing public, business, technological, and environmental climates. The issues and trends discussed in this document and our strategies for addressing them provide the background for the Office of Engineering programs and projects. With a budget in the hundreds of millions annually and increasing public concern, we welcome the opportunity to communicate with our customers. In addition to the factors, trends and issues described in this document are two appendices containing project costs and program and staffing levels. These figures are preliminary with estimates current as of May 13, 1992.

  16. Effect of heat processing and storage time on migration of bisphenol A (BPA) and bisphenol A-diglycidyl ether (BADGE) to aqueous food simulant from Mexican can coatings.

    PubMed

    Munguia-Lopez, E M; Soto-Valdez, H

    2001-08-01

    Effects of heat processing and storage time (up to 70 days) on migration of bisphenol A (BPA) and bisphenol A-diglycidyl ether (BADGE) from can coatings into an aqueous food simulant were determined. Distilled water was canned in two types of Mexican cans: for tuna and for jalapeño peppers. Results showed that there is an effect of heat treatment on migration of both compounds. Storage time did not show any effect in BPA migration from tuna cans. There was an effect of storage time on BPA migration from jalapeño pepper cans. Results for BADGE migration were affected by its susceptibility to hydrolyze in aqueous simulants. BADGE concentration decreased, or was not detected, during storage in both types of cans. Migration levels for BPA and BADGE were within 0.6-83.4 and <0.25-4.3 microg/kg, respectively. Both were below European and Mercosur legislation limits. Other migrating compounds were detected, although no identification was performed. PMID:11513645

  17. Reliability and Factor Structure of the Autism Spectrum Disorders-Behavior Problems for Adults (ASD-BPA) with Intellectual Disabilities and Autism

    ERIC Educational Resources Information Center

    Matson, Johnny L.; Rivet, Tessa T.

    2008-01-01

    This study was designed to establish the initial psychometric properties of the first scale specifically developed for behavior problems of adults with Autism Spectrum Disorders (ASD) and intellectual disability (ID). The Autism Spectrum Disorders-Behavior Problems for Adults (ASD-BPA) consists of 20 items in which raters indicate if each item is…

  18. 40 CFR 300.800 - Establishment of an administrative record.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 29 2013-07-01 2013-07-01 false Establishment of an administrative... the index of documents included in the administrative record file, the RI/FS workplan, the RI/FS released for public comment, the proposed plan, any public comments received on the RI/FS and proposed...

  19. 40 CFR 300.800 - Establishment of an administrative record.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 28 2011-07-01 2011-07-01 false Establishment of an administrative... the index of documents included in the administrative record file, the RI/FS workplan, the RI/FS released for public comment, the proposed plan, any public comments received on the RI/FS and proposed...

  20. 76 FR 38448 - Agency Information Collection Activities: Proposed Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ... ADMINISTRATION Agency Information Collection Activities: Proposed Request The Social Security Administration (SSA... . (SSA) Social Security Administration, DCBFM, Attn: Reports Clearance Officer, 1333 Annex Building, 6401....3625, 418.3645, 418.3665(a), and 418.3670--0960-0702. The Medicare Prescription Drug Improvement...

  1. CDS - Database Administrator's Guide

    NASA Astrophysics Data System (ADS)

    Day, J. P.

    This guide aims to instruct the CDS database administrator in: o The CDS file system. o The CDS index files. o The procedure for assimilating a new CDS tape into the database. It is assumed that the administrator has read SUN/79.

  2. Vocational Education Administration Handbook.

    ERIC Educational Resources Information Center

    Ryals, Karen, Ed.; Doherty, Susan Sloan, Ed.

    This handbook for vocational administrators presents an overview of vocational education programs, services, and administrative structures in Alaska. The manual contains three parts. The first, brief section introduces secondary vocational education and lists its enabling legislation. The second part presents a detailed overview of vocational…

  3. Reframing Research Administration

    ERIC Educational Resources Information Center

    Cole, Sharon Stewart

    2010-01-01

    The purpose of this paper is to inform administrators and organizational leaders that a change in the support offered to faculty and the environment of research administration is desirable. This recommendation is supported by the results of a Delphi study that was undertaken to gather expert opinions and recommendations from research faculty…

  4. Justifying Educational Administration.

    ERIC Educational Resources Information Center

    Evers, Colin; Lakomski, Gabriele

    1993-01-01

    The traditional conceptions of science dominating educational administration are mistaken. Unacceptable epistemologies, like those implicit in logical positivism, justify knowledge solely in terms of empirical adequacy. An improved science of educational administration embraces a coherent global theory accounting for all the phenomena of human…

  5. Migrant Education Administrative Guide.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Compensatory Education.

    Relating specifically to the North Carolina migrant education program's administrative responsibilities, this guide is designed to aid administrators in program management, monitoring project activities, project evaluation, self-assessment, determining needs for training and staff development, site-visit preparation, policy development, and…

  6. DIMENSIONS OF ADMINISTRATIVE PERFORMANCE.

    ERIC Educational Resources Information Center

    HEMPHILL, JOHN; AND OTHERS

    THE MAJOR OBJECTIVES WERE TO DEVELOP CRITERIA FOR THE EVALUATION OF SCHOOL ADMINISTRATION, TO DEFINE THE NATURE OF THE JOB, AND TO DEVELOP AN INSTRUMENT FOR THE SELECTION OF ADMINISTRATORS. THE ELEMENTARY SCHOOL PRINCIPAL WAS CHOSEN FOR THE STUDY BECAUSE OF THE HOST OF PROBLEMS RELATED TO THE CONDUCT OF AN EDUCATIONAL PROGRAM, INCLUDING THE…

  7. Test Administration Models

    ERIC Educational Resources Information Center

    Becker, Kirk A.; Bergstrom, Betty A.

    2013-01-01

    The need for increased exam security, improved test formats, more flexible scheduling, better measurement, and more efficient administrative processes has caused testing agencies to consider converting the administration of their exams from paper-and-pencil to computer-based testing (CBT). Many decisions must be made in order to provide an optimal…

  8. Networked Administration Streamlines Operations.

    ERIC Educational Resources Information Center

    School Planning and Management, 1996

    1996-01-01

    An Iowa school district has retooled its computer systems for more standardized administration. In addition to administration, the district is doing inhouse databasing of financial accounting, and doing inhouse scheduling and grade reporting. A partnership with the Chamber of Commerce contributed $500,000 for the network system. (MLF)

  9. The Administrative Power Grab

    ERIC Educational Resources Information Center

    Sorenson, Richard D.

    2007-01-01

    Administrative power for some school teachers can be an aphrodisiac that can be applied negatively, especially when a leader has devastating instinct for the weaknesses of others. A leader's intellect and heart closes shop and ceases to function when drunk on power. In this article, the author describes how the use of administrative power can be…

  10. Champions of Children. Administrators . . .

    ERIC Educational Resources Information Center

    Chaffee, John; Olds, H. Robert

    Today, in an era of taxpayer revolts, lack of clarity in values, and changing family structure, children need advocates in the political arena as well as in the schools. This pamphlet suggests that administrators are in an excellent position to defend the rights of children on all fronts. It focuses on what administrators have done and specific…

  11. Administration for Student Development.

    ERIC Educational Resources Information Center

    Bergen, J. J., Ed.

    This collection of papers focuses on school administration and its relation to students. It is contended that toay's student matures earlier; has higher expectations; is more affluent; is more isolated from adults; is more critical and outspoken; and, therefore, must be heard by teachers and administrators. A related document is EA 001578.…

  12. Administration of Computer Resources.

    ERIC Educational Resources Information Center

    Franklin, Gene F.

    Computing at Stanford University has, until recently, been performed at one of five facilities. The Stanford hospital operates an IBM 370/135 mainly for administrative use. The university business office has an IBM 370/145 for its administrative needs and support of the medical clinic. Under the supervision of the Stanford Computation Center are…

  13. Rural Administrative Leadership Handbook.

    ERIC Educational Resources Information Center

    Tift, Carolyn

    This resource book on rural administrative leadership is the result of 1988 interviews with school administrators involved in successful rural educational programs. The material is divided into eight chapters, each self-contained for separate use. Chapter 1, "Getting to Know the Community," addresses qualities of living and working in rural…

  14. School Business Administration.

    ERIC Educational Resources Information Center

    Jordan, K. Forbis; Webb, L. Dean

    1986-01-01

    Reviews the societal and organizational changes affecting school business administration, describes major activities encompassed in the practice of school business administration, and reviews current literature specifically related to such activities as electronic data processing, fiscal planning and budgeting, purchasing and property management,…

  15. The Administrative Team.

    ERIC Educational Resources Information Center

    Ohio Association of Elementary School Principals, Westerville.

    Although needs of school districts vary with size, degree of teacher negotiation procedures, and type of community involvement, the administrative team model is presented as an effective, appropriate administrative organization. Based on an assumption that each level of authority in a school district possesses and exercises expertise and unique…

  16. Handbook for Alumni Administration.

    ERIC Educational Resources Information Center

    Webb, Charles H., Ed.

    A definitive look at the field of alumni administration is presented, noting that the subject has until now received little attention. The 34 chapters are divided into nine sections: an overview of alumni administration; alumni as an essential resource; people management; budget and records; programming; communications; alumni education programs…

  17. Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus

    PubMed Central

    Rebuli, Meghan E.; Cao, Jinyan; Sluzas, Emily; Delclos, K. Barry; Camacho, Luísa; Lewis, Sherry M.; Vanlandingham, Michelle M.; Patisaul, Heather B.

    2014-01-01

    Concerns have been raised regarding the long-term impacts of early life exposure to the ubiquitous environmental contaminant bisphenol A (BPA) on brain organization. Because BPA has been reported to affect estrogen signaling, and steroid hormones play a critical role in brain sexual differentiation, there is also concern that BPA exposure could alter neural sex differences. Here, we examine the impact of subchronic exposure from gestation to adulthood to oral doses of BPA below the current no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day on estrogen receptor (ESR) expression in sexually dimorphic brain regions of prepubertal and adult female rats. The dams were gavaged daily with vehicle (0.3% carboxymethylcellulose), 2.5, 25, 260, or 2700 μg BPA/kg bw/day, or 0.5 or 5.0 μg ethinyl estradiol (EE)/kg bw/day from gestational day 6 until labor began. Offspring were then gavaged directly from the day after birth until the day before scheduled sacrifice on postnatal days 21 or 90. Using in situ hybridization, one or more BPA doses produced significant decreases in Esr1 expression in the juvenile female rat anteroventral periventricular nucleus (AVPV) of the hypothalamus and significant decreases in Esr2 expression in the adult female rat AVPV and medial preoptic area (MPOA), relative to vehicle controls. BPA did not simply reproduce EE effects, indicating that BPA is not acting solely as an estrogen mimic. The possible consequences of long-term changes in hypothalamic ESR expression resulting from subchronic low dose BPA exposure on neuroendocrine effects are discussed and being addressed in ongoing, related work. PMID:24752507

  18. 47 CFR 54.715 - Administrative expenses of the Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Administrative expenses of the Administrator. 54.715 Section 54.715 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) UNIVERSAL SERVICE Administration § 54.715 Administrative expenses of the Administrator. (a) The annual administrative expenses...

  19. 47 CFR 54.715 - Administrative expenses of the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Administrative expenses of the Administrator. 54.715 Section 54.715 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) UNIVERSAL SERVICE Administration § 54.715 Administrative expenses of the Administrator. (a) The annual administrative expenses...

  20. Head of Administration

    NASA Astrophysics Data System (ADS)

    2005-03-01

    Purpose and scope of the position: The main task is to provide efficient administrative services and advice to the Director General, Division Leaders and to staff members in the scientific and technical areas in the fields of financial planning and accounting, personnel management, purchasing, legal and contractual matters, information systems and building and site maintenance. As a member of the ESO Management the Head of Administration contributes essentially to the development of the overall policy, strategic planning, relations to the members of the personnel and maintains professional contacts at highest level outside the Organisation. ESO employs in total approximately 650 staff members and the Administration Division comprises the Administration at the Headquarters in Garching near Munich and the Administration in Santiago (Chile). The successful candidate will be supported by some 50 qualified staff members.

  1. 45 CFR 160.420 - Notice of proposed determination.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Notice of proposed determination. 160.420 Section 160.420 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS GENERAL ADMINISTRATIVE REQUIREMENTS Imposition of Civil Money Penalties § 160.420 Notice of proposed determination. (a) If a...

  2. Early utility experience with wind power generation. Volume 3: Bonneville Power Administration Goodnoe Hills Project. Final report

    SciTech Connect

    McCabe, T.; Henry, G.; Tennis, M.; Goldenblatt, M.

    1984-01-01

    This report is one of three presenting the results of EPRI Research Project 1590-1, Evaluation of Electric Utility Experience with Wind Power Generation. The objective of this project was to develop an improved understanding of wind power generation, in particular the process a utility must undergo to initiate and carry out a wind turbine project. The primary tasks of RP1590-1 were to document and evaluate the experience of two utilities with megawatt-scale wind turbine installations from project inception to the wind turbine's first rotation. This technical report presents the experiences of the Bonneville Power Administration (BPA) as the participating utility in the MOD-2 cluster field test program. Under this program the National Aeronautics and Space Administration (NASA) as management agent for the US Department of Energy, has installed three MOD-2 wind turbines at Bonneville's Goodnoe Hills site. All documents and reports pertaining to BPA's experience with wind energy at Goodnoe Hills were reviewed and excerpts made of the highlights. Gaps in the documentation were filled by talking with the appropriate people. Site visits were conducted to monitor current activity. The information obtained was evaluated for its generic relevance and benefit to other utilities. The chronology of the steps taken in implementing the wind turbine project and some of the lessons learned are included in the report. In each section, important activities, critical assumptions, and interesting insights which might benefit other utility wind programs are identified.

  3. Removal of BPA model compounds and related substances by means of column chromatography using Octolig®.

    PubMed

    Alessio, Rachael J; Li, Xiao; Martin, Dean F

    2012-01-01

    Octolig®, a polyethylenediimine ligand covalently attached to high-surface area silica gel, was used to study the removal of phenolic compounds from aqueous samples by column chromatography. Model phenolic compounds of Bisphenol A (BPA), 4-isopropylphenol and 4-(t-butyl) phenol, were selected for this study due to their similarities in pKa and log P values. The percent removal of these compounds by Octolig® was 26 ± 2 and 22 ± 2, respectively. Furthermore, the three isomers of nitrophenol were investigated as well as additional phenolic compounds, such as amoxicillin and five phenolic dyes. These compounds have a pKa range of 2-10.2. The compounds that have pKa values less than 8.3 were able to be completely removed by Octolig®, yet compounds with pKa values of 8.3 and higher resulted in approximately 20-26% removal. PMID:22934990

  4. Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations

    PubMed Central

    Manikkam, Mohan; Tracey, Rebecca; Guerrero-Bosagna, Carlos; Skinner, Michael K.

    2013-01-01

    Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1–F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived endocrine disruptor compounds bisphenol-A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP) at two different doses promoted epigenetic transgenerational inheritance of adult onset disease and associated DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to either the “plastics” or “lower dose plastics” mixture during embryonic days 8 to 14 of gonadal sex determination and the incidence of adult onset disease was evaluated in F1 and F3 generation rats. There were significant increases in the incidence of total disease/abnormalities in F1 and F3 generation male and female animals from plastics lineages. Pubertal abnormalities, testis disease, obesity, and ovarian disease (primary ovarian insufficiency and polycystic ovaries) were increased in the F3 generation animals. Kidney and prostate disease were only observed in the direct fetally exposed F1 generation plastic lineage animals. Analysis of the plastics lineage F3 generation sperm epigenome previously identified 197 differential DNA methylation regions (DMR) in gene promoters, termed epimutations. A number of these transgenerational DMR form a unique direct connection gene network and have previously been shown to correlate with the pathologies identified. Observations demonstrate that a mixture of plastic derived compounds, BPA and phthalates, can promote epigenetic transgenerational inheritance of adult onset disease. The sperm DMR provide potential epigenetic biomarkers for transgenerational disease and/or ancestral environmental exposures. PMID:23359474

  5. Serving the Space Administration

    ERIC Educational Resources Information Center

    Campbell, Jack E.; Thompson, Arthur W.

    1974-01-01

    The purpose of the current program was to establish an upward mobility program that afforded employees an opportunity to improve their credibility in job opportunity selection under the directives of the National Aeronautics and Space Administration. (Author/RK)

  6. Copyright Implications for Administrators.

    ERIC Educational Resources Information Center

    Simpson, Carol Mann

    1994-01-01

    Discusses copyright compliance policies for school administrators and the librarian's role in policy implementation. Topics addressed include fines; court litigation; monitoring compliance; training sessions for teachers and staff; computer software audits; and sources for more information. (LRW)

  7. Goldstone (GDSCC) administrative computing

    NASA Technical Reports Server (NTRS)

    Martin, H.

    1981-01-01

    The GDSCC Data Processing Unit provides various administrative computing services for Goldstone. Those activities, including finance, manpower and station utilization, deep-space station scheduling and engineering change order (ECO) control are discussed.

  8. Confrontation and Administrative Response

    ERIC Educational Resources Information Center

    Auerbach, Arnold J.

    1969-01-01

    Describes some of the sociological and psychological effects of organizational conflict and offers 10 operational principles to guide public administrators of schools and social agencies in meeting the confrontation tactics of activist groups. (JH)

  9. One for the Administrators

    ERIC Educational Resources Information Center

    American School and University, 1978

    1978-01-01

    Earth berms, a heavily insulated roof, and a narrow band of thermal pane windows, save energy at the administrative headquarters of the Anoka Hennepin school district in Coon Rapids, a suburb of Minneapolis, Minnesota. (Author/MLF)

  10. The Purchasing Administrator.

    ERIC Educational Resources Information Center

    Ferguson, Joyce E.

    1985-01-01

    Discusses the professional purchasing administrator's most common areas of responsibility: (1) staffing the department, (2) maintaining professional objectivity in vendor relationships, (3) following bidding policies, (4) receiving user input and feedback, and (5) seeking local equipment service and maintenance. (MLF)

  11. Introducing Public Administration

    ERIC Educational Resources Information Center

    Stein, Jay W.

    1975-01-01

    The use of documents and the analysis of definitions are recommended as a means for adding zest to an introduction to public administration course to obtain student interest and motivation. (Author/ND)

  12. SPRITE: the Spitzer proposal review website

    NASA Astrophysics Data System (ADS)

    Crane, Megan K.; Storrie-Lombardi, Lisa J.; Silbermann, Nancy A.; Rebull, Luisa M.

    2008-07-01

    The Spitzer Science Center (SSC), located on the campus of the California Institute of Technology, supports the science operations of NASA's infrared Spitzer Space Telescope. The SSC issues an annual Call for Proposals inviting investigators worldwide to submit Spitzer Space Telescope proposals. The Spitzer Proposal Review Website (SPRITE) is a MySQL/PHP web database application designed to support the SSC proposal review process. Review panel members use the software to view, grade, and write comments about the proposals, and SSC support team members monitor the grading and ranking process and ultimately generate a ranked list of all the proposals. The software is also used to generate, edit, and email award letters to the proposers. This work was performed at the California Institute of Technology under contract to the National Aeronautics and Space Administration.

  13. The Value Bases of Administrative Action.

    ERIC Educational Resources Information Center

    Hodgkinson, Christopher

    This paper proposes a method for understanding the relationships among the various value systems that underlie administrative thinking. The system takes into account the psychological faculties affecting ethical decisions, the philosophical orientations involved, and distinctions between the concepts of "right" and "good." The paper opens with…

  14. Comprehensive Career Education. School Administrator's Guide.

    ERIC Educational Resources Information Center

    Kennedy, Elsie

    The first of five documents developed as an outgrowth of funded programs for career education in Kentucky, the school administrator's guide offers an overview of career education covering goals, curriculum relevancy, components, roles, and stages of development. Some basic conceptual components proposed are: (1) self-awareness, (2) career…

  15. 48 CFR 19.812 - Contract administration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., unless the Administrator of the SBA waives the requirement for contract termination (13 CFR 124.515). The... proposed transfer and its effect on contract performance and mission support. If the contracting officer.... This requirement for a convenience termination does not affect the Government's right to terminate...

  16. 48 CFR 19.812 - Contract administration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., unless the Administrator of the SBA waives the requirement for contract termination (13 CFR 124.515). The... proposed transfer and its effect on contract performance and mission support. If the contracting officer.... This requirement for a convenience termination does not affect the Government's right to terminate...

  17. 48 CFR 19.812 - Contract administration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., unless the Administrator of the SBA waives the requirement for contract termination (13 CFR 124.515). The... proposed transfer and its effect on contract performance and mission support. If the contracting officer.... This requirement for a convenience termination does not affect the Government's right to terminate...

  18. Written Communications and the School Administrator.

    ERIC Educational Resources Information Center

    Joyce, Audrey B.

    Aimed at assisting school administrators in writing letters, memos, reports, grant proposals, press releases, summaries, research papers, and other types of documents, this book is organized into three parts. Part 1 covers activities conducted before drafting the document. Following an introductory chapter reviewing four stages of the writing…

  19. Information System for Educational Policy and Administration.

    ERIC Educational Resources Information Center

    Clayton, J. C., Jr.

    Educational Information System (EIS) is a proposed computer-based data processing system to help schools solve current educational problems more efficiently. The system would allow for more effective administrative operations in student scheduling, financial accounting, and long range planning. It would also assist school trustees and others in…

  20. Quality in University Student Administration: Stakeholder Conceptions

    ERIC Educational Resources Information Center

    Shanahan, Peter; Gerber, Rod

    2004-01-01

    This paper examines the varying experiences of quality amongst key stakeholders (those who have an interest in, an impact on or are users of) in faculty student administration in an Australian university and proposes a framework for understanding quality in this context. Data were obtained using a qualitative phenomenographic research approach and…

  1. 42 CFR 8.32 - Administrative record.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Administrative record. 8.32 Section 8.32 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension or Proposed Revocation of OTP...

  2. 42 CFR 8.32 - Administrative record.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Administrative record. 8.32 Section 8.32 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension or Proposed Revocation of OTP...

  3. 42 CFR 8.32 - Administrative record.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Administrative record. 8.32 Section 8.32 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for Review of Suspension or Proposed Revocation of OTP...

  4. Approaching hospital administration about adopting cooling technologies.

    PubMed

    Kirkland, Lisa L; Parham, William M; Pastores, Stephen M

    2009-07-01

    The purpose of this article is to provide intensivists with information and examples regarding cooling technology selection, cost assessment, adaptation, barriers, and presentation to hospital administrators. A review of medical and business literature was conducted using the following search terms: technology assessment, organizational innovation, intensive care, critical care, hospital administration, and presentation to administrators. General recommendations for intensivists are made for assessing cooling technology with descriptions of common new technology implementation stages. A study of 16 hospitals implementing a new cardiac surgery technology is described. A description of successful implementation of an induced hypothermia protocol by one of the authors is presented. Although knowledgeable about the applications of new technologies, including cooling technology, intensivists have little guidance or training on tactics to obtain a hospital administration's funding and support. Intensive care unit budgets are usually controlled by nonintensivists whose interests are neutral, at best, to the needs of intensivists. To rise to the top of the large pile of requisition requests, an intensivist's proposal must be well conceived and aligned with hospital administration's strategic goals. Intensivists must understand the hospital acquisition process and administrative structure and participate on high-level hospital committees. Using design thinking and strong leadership skills, the intensivist can marshal support from staff and administrators to successfully implement cooling technology. PMID:19535961

  5. Astronaut Administrator Richard Truly

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Astronaut Richard H. Truly, pilot of the Space Shuttle Columbia on mission STS-2 and Commander of Shuttle Challenger on mission STS-8, became NASA's eighth Administrator on July 1, 1989. One day earlier he concluded a 30 year Naval career retiring as a Vice Admiral. He was the first astronaut to head the nation's civilian space agency. Truly became Deputy Associate Administrator for Space Flight on February 20, 1986. In this position, he led the painstaking rebuilding of the Space Shuttle program less than one month after the Challenger disaster. This was highlighted by the much heralded 'Return to Flight' on September 29, 1988 with the launch of Shuttle Discovery, 32 months after Challenger's final flight. On February 12th, 1992 Richard Truly resigned as NASA Administrator at the request of President George Bush.

  6. 78 FR 29383 - Proposed Collection, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... injury and illness prevention strategies; and to support Occupational Safety and Health Administration... of Occupational Injuries and Illnesses.'' A copy of the proposed information collection request (ICR...) of the Occupational Safety and Health Act of 1970 requires the Secretary of Labor to develop...

  7. 75 FR 20004 - Proposed Collection, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... and illness prevention strategies; and to support Occupational Safety and Health Administration (OSHA... of Occupational Injuries and Illnesses.'' A copy of the proposed information collection request (ICR...) of the Occupational Safety and Health Act of 1970 requires the Secretary of Labor to develop...

  8. 78 FR 29123 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... instruments, please write to: Air Force Safety Automated System Administrator, HQ AFSEC/SEAC, 9700 G Ave SE... Department of the Air Force Proposed Collection; Comment Request AGENCY: Department of Defense/Department of the Air Force/Headquarters, Air Force Safety Center (AFSEC), DoD. ACTION: Notice. In compliance...

  9. 78 FR 14620 - Joint Development: Proposed Circular

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... published guidance on the eligibility of joint development activities for FTA funding. 72 FR 5788 (Feb. 7... review DOT's complete Privacy Act Statement published in the Federal Register on April 11, 2000 (65 FR... Federal Transit Administration Joint Development: Proposed Circular AGENCY: Federal Transit...

  10. 78 FR 51176 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ..., Illinois, 62225-5006; email to tony.mayo@us.army.mil ; or call the Department of the Army Reports Clearance... Department of the Army Proposed Collection; Comment Request AGENCY: Office of the Administrative Assistant to the Secretary of the Army, (OAA-AAHS), DoD. ACTION: Notice. In compliance with Section...

  11. Computer hardware fault administration

    DOEpatents

    Archer, Charles J.; Megerian, Mark G.; Ratterman, Joseph D.; Smith, Brian E.

    2010-09-14

    Computer hardware fault administration carried out in a parallel computer, where the parallel computer includes a plurality of compute nodes. The compute nodes are coupled for data communications by at least two independent data communications networks, where each data communications network includes data communications links connected to the compute nodes. Typical embodiments carry out hardware fault administration by identifying a location of a defective link in the first data communications network of the parallel computer and routing communications data around the defective link through the second data communications network of the parallel computer.

  12. MCS Systems Administration Toolkit

    2001-09-30

    This package contains a number of systems administration utilities to assist a team of system administrators in managing a computer environment by automating routine tasks and centralizing information. Included are utilities to help install software on a network of computers and programs to make an image of a disk drive, to manage and distribute configuration files for a number of systems, and to run self-testss on systems, as well as an example of using amore » database to manage host information and various utilities.« less

  13. One-step signal amplified lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A (BPA) in aqueous samples.

    PubMed

    Mei, Zhanlong; Qu, Wei; Deng, Yi; Chu, Huaqin; Cao, Jinxuan; Xue, Feng; Zheng, Lei; El-Nezamic, Hani Said; Wu, Yucheng; Chen, Wei

    2013-11-15

    A one-step signal amplified lateral flow strip (LFS) biosensor has been developed for ultrasensitive and on-site visual detection of bisphenol A (BPA). This signal amplified LFS was based on the dual labeling using different-sized gold nanoparticles (Duo-LFS). This Duo-LFS could achieve BPA detection with 0.5 ng/mL as the visual sensitivity by naked eye observation and with 0.076 ng/mL as the limit of detection (LOD) for semi-quantitative detection by software analysis, which is at least 10-fold improvement of the sensitivity of traditional LFS based methods. This one-step signal amplified lateral flow strip biosensor and related signal enhancement method could be adopted as a potential generous technique for all LFS-based detection methods. PMID:23811478

  14. In vitro impact of bisphenols BPA, BPF, BPAF and 17β-estradiol (E2) on human monocyte-derived dendritic cell generation, maturation and function.

    PubMed

    Švajger, Urban; Dolenc, Marija Sollner; Jeras, Matjaž

    2016-05-01

    Bisphenols (BPs) are widely spread pollutants that act as estrogen-like endocrine disruptors and are potentially affecting human health on a long run. We explored the effects of BPA, BPF and BPAF, on in vitro differentiation and maturation of MDDCs. Monocytes were treated with 17β-estradiol (E2) and each BP at the beginning of their differentiation into iMDDCs. We found that 10 and 50 μM of BPA and BPF, 10 and 30μM of BPAF and 10 and 50 nM of E2 did not affect cell viability. However, 50 μM of BPA and BPF, as well as 10 and 30 μM of BPAF, significantly decreased the endocytotic capacity of iMDDCs. Both, BPA (50 μM) and BPAF (30 μM) decreased the expression of CD1a and increased the amount of DC-SIGN molecules on iMDDCs. The E2 pre-treatment moderately decreased expression of CD80, CD86 and CD83 co-stimulatory molecules while increasing the numbers of HLA-DR on mMDDCs. Only BPAF significantly influenced the expression of CD80 and CD86 (both decreased), as well as CD83 and HLA-DR molecules (both increased) on mMDDCs. In addition, BPAF modulated DC maturation signaling pathways by lowering the phosphorylation of p65 NF-κB (nuclear factor-kappaB) and ERK (extracellular signal regulated kinase) 1/2 proteins. Consequently, the in vitro proliferation of allogeneic T cells, stimulated with differently pre-treated iMDDCs and mMDDCs, was significantly reduced only in case of BPAF. PMID:26945833

  15. Comparing different gas chromatographic methods for the quantification of bisphenol A (BPA) trace levels in paper and cardboard products from the market.

    PubMed

    Jurek, A; Leitner, E

    2015-01-01

    Bisphenol A (BPA; 4,4'-(propane-2,2-diyl)diphenol), a suspected endocrine disruptor with weak estrogenic activity, is used in a variety of consumer products, including paper and cardboard products used as food contact materials. The present study compared four different gas chromatographic methods for the analysis of BPA in paper and cardboard food packages. Eighteen different food packages were extracted and BPA was determined using two different derivatisation reactions--trimethylsilylation with N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) and halide alkylation with pentafluorobenzoyl chloride (PFBOCl)--and four different separation and detection techniques. The BSTFA derivatives were quantified with (1) GC-MS in single-ion monitoring (SIM) mode with electron ionisation (EI-GC-MS) and (2) GC-MS/MS in multiple reaction monitoring (MRM) mode using electron ionisation (EI-GC-MS/MS); while the PFBOCl derivatives were quantified with (3) GC-MS using electron ionisation (EI-GC-MS) as well as (4) GC-MS with negative chemical ionisation (NCI-GC-MS). All developed methods showed good linearity (R(2) > 0.9938), precision (CV < 4.5% for reproducibility; CV < 2.2% for repeatability) and sensitivity, with limits of detection (LODs) between 0.02 µg kg(-1) for the pentafluorobenzoyl derivatives measured with the NCI-GC-MS method and 6 µg kg(-1) for the pentafluorobenzoyl derivatives determined with EI-GC-MS. Levels of BPA in the samples were in agreement for all methods, ranging from values below the limit of quantitation (LOQ) to 11.9 mg kg(-1) paper. In a last step, the maximum potential migration into food products was calculated for all tested paper and cardboard samples, assuming a 'worst case' scenario of 100% migration. PMID:26029846

  16. [Patient-Proposed Health Services].

    PubMed

    Fujiwara, Yasuhiro

    2016-06-01

    The Patient-Proposed Health Services(PPHS)was launched in April 2016. PPHS was proposed by the Council for Regulatory Reform, which was established in January 2013 under the Second Abe Administration. After discussion within the council, PPHS was published in the Japan Revitalization Strategy(2014 revised edition), which was endorsed by the Cabinet on June 24, 2014. PPHS was proposed therein as a new mechanism within the mixed billing system to apply for a combination of treatment not covered by the public health insurance with treatment covered by the insurance. Subsequently, PPHS was submitted for diet deliberations in April and May 2015 and inserted into article 63 of the health insurance act in accordance with "a law for making partial amendments to the National Health Insurance Act, etc., in order to create a sustainable medical insurance system", which was promulgated on May 29, 2015. In this paper I will review the background of the birth of PPHS and discuss its overview. PMID:27306801

  17. Additive effect of BPA and Gd-DTPA for application in accelerator-based neutron source.

    PubMed

    Yoshida, F; Yamamoto, T; Nakai, K; Zaboronok, A; Matsumura, A

    2015-12-01

    Because of its fast metabolism gadolinium as a commercial drug was not considered to be suitable for neutron capture therapy. We studied additive effect of gadolinium and boron co-administration using colony forming assay. As a result, the survival of tumor cells with additional 5 ppm of Gd-DTPA decreased to 1/10 compared to the cells with boron only. Using gadolinium to increase the effect of BNCT instead of additional X-ray irradiation might be beneficial, as such combination complies with the short-time irradiation regimen at the accelerator-based neutron source. PMID:26242560

  18. Telecommunications administration standard

    SciTech Connect

    Gustwiller, K.D.

    1996-05-01

    The administration of telecommunications is critical to proper maintenance and operation. The intent is to be able to properly support telecommunications for the distribution of all information within a building/campus. This standard will provide a uniform administration scheme that is independent of applications, and will establish guidelines for owners, installers, designers and contractors. This standard will accommodate existing building wiring, new building wiring and outside plant wiring. Existing buildings may not readily adapt to all applications of this standard, but the requirement for telecommunications administration is applicable to all buildings. Administration of the telecommunications infrastructure includes documentation (labels, records, drawings, reports, and work orders) of cables, termination hardware, patching and cross-connect facilities, telecommunications rooms, and other telecommunications spaces (conduits, grounding, and cable pathways are documented by Facilities Engineering). The investment in properly documenting telecommunications is a worthwhile effort. It is necessary to adhere to these standards to ensure quality and efficiency for the operation and maintenance of the telecommunications infrastructure for Sandia National Laboratories.

  19. Study Shows Administrative Shortage.

    ERIC Educational Resources Information Center

    Sullivan, John R., Jr.

    1989-01-01

    Summarizes "Administrative Shortage in New England: The Evidence, the Causes, the Recommendations." High pressure, long hours, low salaries, and high housing costs are among the reasons cited for the shortage. Recommendations are centered on role identity, staff support, training, and recruitment. (SI)

  20. Guidebook for School Administrators.

    ERIC Educational Resources Information Center

    Hess, Fritz, Ed.

    To provide guidance and advice regarding day-to-day responsibilities of new and experienced school administrators and superintendents in New York State, this compendium of knowledge and advice submitted by practitioners is presented with emphasis on all major aspects of superintendency. The section on general aspects of superintendency includes…